Biology seminar: Biology of Aging
BIO 425
Instructor: Jim Lund


Papers can be found searching at these sites:
NCBI Pubmed
Google Scholar
Older publications can be found in the library.

Week Topic Paper(s) Presenter
1 Discovery of the role of the Insulin-like signaling pathway's in aging. A C. elegans mutant that lives twice as long as wild type. Cynthia Kenyon, Jean Chang, Erin Gensch, Adam Rudner, Ramon Tabtiang Nature 366, 461 - 464 (1993), HTML, PDF  
2 Insulin-like signaling pathway (ISP) extends lifespan in mouse. IGF-1 receptor regulates lifespan and resistance to oxidative stress in mice. Martin Holzenberger, Joëlle Dupont, Bertrand Ducos, Patricia Leneuve, Alain Géloën, Patrick C. Even, Pascale Cervera, Yves Le Bouc Nature 421, 182-187 (9 January 2003), HTML, PDF
In Pursuit of the Longevity Dividend: What Should We Be Doing To Prepare for the Unprecedented Aging of Humanity? S. Jay Olshansky, Ph.D., Daniel Perry, Richard A. Miller, M.D., Ph.D., and Robert N. Butler, M.D., HTML, PDF
Terpsichore L.
3 Lifespan and metabolic scaling laws Field metabolic rate and body size. Kenneth A. Nagy. Journal of Experimental Biology 208, 1621-1625 (2005)., HTML, PDF
Living Fast, Dying When? The Link between Aging and Energetics. John R. Speakman, Colin Selman, Jane S. McLaren, and E. Jean Harper. J. Nutr. 132:1583S-1597S, June 2002 HTML, PDF
Corey D.
4 Evolution of lifespan. Laboratory evolution of postponed senescence in Drosophila melanogaster. Michael Rose, PDF Matthew W.
5 SIR2 extends lifespan in yeast The SIR2/3/4 complex and SIR2 alone promote longevity in Saccharomyces cerevisiae two different mechanisms. Matt Kaeberlein, Mitch McVey, and Leonard Guarente. Genes & Dev. 1999. 13: 2570-2580 HTML, PDF
Optional reading:
Increased dosage of a sir-2 gene extends lifespan in Caenorhabditis elegans. Heidi A. Tissenbaum & Leonard Guarente. Nature 410, 227-230 (8 March 2001) HTML, PDF
Science fact and the SENS agenda. Huber Warner,a Julie Anderson, Steven Austad, Ettore Bergamini, Dale Bredesen, Robert Butler, Bruce A. Carnes, Brian F. C. Clark, Vincent Cristofalo, John Faulkner, Leonard Guarente, David E. Harrison, Tom Kirkwood, Gordon Lithgow, George Martin, Ed Masoro, Simon Melov, Richard A. Miller, S. Jay Olshansky, Linda Partridge, Olivia Pereira-Smith, Tom Perls, Arlan Richardson, James Smith, Thomas von Zglinicki, Eugenia Wang, Jeanne Y. Wei, and T. Franklin Williams. EMBO Rep. 2005 November; 6(11): 1006-1008., HTML, PDF
Mary W.
6 mouse resvertrol Resveratrol delays age-related deterioration and mimics transcriptional aspects of dietary restriction without extending lifespan. Kevin J. Pearson, Joseph A. Baur, Kaitlyn N. Lewis, Leonid Peshkin, Nathan L. Price, Nazar Labinskyy, William R. Swindell, Davida Kamara, Robin K. Minor, Evelyn Perez, Hamish A. Jamieson, Yongqing Zhang, Stephen R. Dunn, Kumar Sharma, Nancy Pleshko, Laura A. Woollett, Anna Csiszar, Yuji Ikeno, David Le Couteur, Peter J. Elliott, Kevin G. Becker, Placido Navas, Donald K. Ingram, Norman S. Wolf, Zoltan Ungvari, David A. Sinclair, and Rafael de Cabo. Cell Metab. 2008 August; 8(2): 157-168., HTML, PDF
Murine Models of Life Span Extension. Quarrie and Riabowol, 2004, SAGE KE., PDF
Christine H.
7 Human genetics of longevity Genetics of exceptional longevity. Thomas Perls and Dellara Terry. Experimental Gerontology Volume 38, Issue 7, July 2003, Pages 725-730., HTML, PDF Marlice K.
8 TOR pathway in C. elegans The TOR pathway interacts with the insulin signaling pathway to regulate C. elegans larval development, metabolism and life span. Kailiang Jia, Di Chen and Donald L. Riddle. Development 131, 3897-3906 (2004)., HTML, PDF
Optional reading:
The Target of Rapamycin Pathway Antagonizes pha-4/FoxA to Control Development and Aging. Karyn L. Sheaffer, Dustin L. Updike, and Susan E. Mango. Curr Biol Volume 18, Issue 18, 23 September 2008, Pages 1355-1364., HTML
Sara S.
9 Rapamycin treatment (TOR) in mouse Rapamycin fed late in life extends lifespan in genetically heterogeneous mice. David E. Harrison Randy Strong Zelton Dave Sharp James F. Nelson Clinton M. Astle Kevin Flurkey Nancy L. Nadon J. Erby Wilkinson Krystyna Frenkel Christy S. Carter Marco Pahor Martin A. Javors Elizabeth Fernandez & Richard A. Mille. Nature 460, 392-395 (16 July 2009)., HTML, PDF Courtney A.
10 ISP regulated genes New Genes Tied to Endocrine, Metabolic, and Dietary Regulation of Lifespan from a Caenorhabditis elegans Genomic RNAi Screen. Malene Hansen, Ao-Lin Hsu, Andrew Dillin, Cynthia Kenyon. PLoS. 2005. 1:119-28., HTML, PDF Jordan L.
11 Caloric restriction in Rhesus monkeys Caloric Restriction Delays Disease Onset and Mortality in Rhesus Monkeys. Ricki J. Colman, Rozalyn M. Anderson, Sterling C. Johnson, Erik K. Kastman, Kristopher J. Kosmatka, T. Mark Beasley, David B. Allison, Christina Cruzen, Heather A. Simmons, Joseph W. Kemnitz, Richard Weindruch. Science 10 July 2009: Vol. 325. no. 5937, pp. 201 - 204., HTML, PDF Francoise U.
12 Human genetic variation and longevity Association of the FOXO3A Locus with Extreme Longevity in a Southern Italian Centenarian Study. Chiara Viviani Anselmi, Alberto Malovini, Roberta Roncarati, Valeria Novelli, Francesco Villa, Gianluigi Condorelli, Riccardo Bellazzi, and Annibale Alessandro Puca. Rejuv Res. Volume 12, Number 2, 2009., PDF Keegan B.
13 Activating telomerase in the mouse Telomerase Reverse Transcriptase Delays Aging in Cancer-Resistant Mice.
Antonia Tomás-Loba Ignacio Flores, Pablo J. Fernández-Marcos, María L. Cayuela, Antonio Maraver, Agueda Tejera, Consuelo Borrás, Ander Matheu, Peter Klatt, Juana M. Flores, José Viña, Manuel Serrano, and Maria A. Blasco.
Cell. Volume 135, Issue 4, 14 November 2008, Pages 609-622.
Michelle S.
14 Screen for anti-aging drugs Anticonvulsant Medications Extend Worm Life-Span
Kimberley Evason, Cheng Huang, Idella Yamben, Douglas F. Covey, Kerry Kornfeld.
Science 14 January 2005: Vol. 307. no. 5707, pp. 258-262.
Sara H.
15 Aging of nuclear pores Age-Dependent Deterioration of Nuclear Pore Complexes Causes a Loss of Nuclear Integrity in Postmitotic Cells.
Maximiliano A. D'Angelo1, Marcela Raices1, Siler H. Panowski1 and Martin W. Hetzer.
Cell. Volume 136, Issue 2, 23 January 2009, Pages 284-295