Biology of Aging
Instructor: Jim Lund

IntroBioAging ppt pdf
HumanDemographics ppt pdf
ComparativeAging ppt pdf
PhenotypeI ppt pdf
PhenotypeII ppt pdf
WhyAge? ppt pdf
AgingCommonalities ppt pdf
Progerias ppt pdf
ProgeriasII ppt pdf
Cancer ppt pdf
Telomeres ppt pdf
Telomeres II ppt pdf
Vascular disease & Neurodegenerationppt pdf
Junk Anti-Aging ppt pdf
Centenarians ppt pdf
AgingTheoryI ppt pdf
Caloric restriction ppt pdf
CR: Mechanisms ppt pdf
Insulin-like pathway ppt pdf
Insulin-like pathwayII ppt pdf
Sirulins ppt pdf
Mouse models ppt pdf
Environment & Lifestyle ppt pdf
Stress Resistance ppt pdf
Heat shock proteins ppt pdf
Recent discoveriesppt pdf
Next50yrs ppt pdf
Final exam is Friday 12/19 at 1 pm!
Extra credit was due Monday 11/17
Exam 2 was Weds 11/5
Exam 1 was Monday 9/29
Old exams: Exam 1 Exam 2 Final exam

Please read the Fall 2008 syllabus --it contains answers to most initial questions.

Reading to be discussed in class 12/8/08: IGF-1 receptor regulates lifespan and resistance to oxidative stress in mice. PDF HTML

Reading assigned: Time to Talk SENS: Critiquing the Immutability of Human Aging (pdf)

Reading assigned: Position Statement on Human Aging (pdf)

Reading assigned: Murine Models of Life Span Extension. Quarrie and Riabowol, 2004, SAGE KE (pdf)

Reading assigned: Mitochondrial dysfunction as a cause of ageing (pdf)

Reading assigned: Handbook of Aging 5th ed., Ch15 (pdf)

Reading assigned: Oxidative Stress, Mitochondrial DNA Mutation, and Apoptosis in Aging (pdf)

In the news: South African Woman Says She is 134 Years Old
According to the article, "her birth pre-dated record keeping" so her case likely will remain unverified.

Reading assigned: Okinawa Centenarian Study (main page introduces the study) Reading assigned: Okinawa Centenarian Study (highlights results of the study)

FYI: Quackwatch article on one of the anti-aging scammers

Reading assigned: National Institute on Aging Health Quackery acticle

FYI: Current treatments for Alzheimer's disease

FYI: 2008 GFP Nobel Prize background info

FYI: GFP info associated with the book Glowing Genes

FYI: GFP slides shown in class

Background reading:
Coronary Artery Disease (National Heart, Lung, and Blood Institute)

Reading assigned: Handbook of the Biology of Aging, Ch 9: Apoptosis and Aging

Background reading:
What is cancer (National Cancer Institute

Reading assigned: Handbook of the Biology of Aging, Ch 8: Cell Proliferation in Mammalian Aging

Background reading:
Gene expression:
The role of a promoter in turning on a gene.
Genetic engineering basics:
Recombinant DNA Technology
Combining pieces of DNA
Polymerase chain reaction
HHMI site where I found these animations. Check out the videos and lectures too!

FYI: A Kentucky child has Hutchinson-Gilford progeria

Correction: In Hutchinson-Gilford progeria both autosomal dominant and autosomal recessive cases have been reported, the classic cases are autosomal dominant.

FYI: An OMIM entry on skin/hair/eye pigmentation

Reading assigned: Genetic alterations in accelerated ageing syndromes Do they play a role in natural ageing? Monika Puzianowska-Kuznicka. Jacek Kuznicki. 2005. IJBCB, 37; 947-60.

Reading assigned: OMIM entry for Werner syndrome

Reading assigned: OMIM entry for Hutchinson-Gilford progeria syndrome

Discussed in class Friday 9/19: Laboratory Evolution of Postponed Senescence in Drosophila. MR Rose. Evolution. v38; 1004-10

Reading assigned: Aging A Natural History by Ricklefs and Finch, Ch 7 (pdf)

FYI: The Index to Creationist Claims

Background reading: Modern Synthesis of Genetics and Evolution

Background reading: Wikipedia background on Alzheimer's disease

I would like you to read enough background to understand my discussion of aging in the immune system. Here are two sources, one from Wikipedia and one from the PubMed bookshelf.
Background reading: Wikipedia background on the adpative immune system

Background reading: PubMed bookshelf -> Immunobiology -> components of the immune system

FYI: PubMed books

FYI: Test your hearing!

Reading assigned: Aging A Natural History by Ricklefs and Finch, Ch 4 (pdf)

FYI: Red sea urchins (Strongylocentrotus franciscanus) can live over 100 years: confirmation with A-bomb 14carbon

FYI: Oldest people

Things to know: Have a look at the human genome: Ensembl human genome browser

Reading assigned: Why We Age Ch 2 and Ch 3. (pdf)