Dybbs et al 2005, unc-43 vs wt differ genes, 38 genes Gene list file name: Dybbs2005_Fig3_unc-43_vs_wt_differ_genes.txt Type of gene identifier: Affymetrix probe set Description: Dybbs2005 et al 2005, Fig3, reduced expression in unc-43(n1186) compared with wt (fold-change <-0.5, p<0.01) Organism: Caenorhabditis elegans (nematode) Gene list type: Experimental Gene name Source Gene ID All gene names WormBase description WormBase CDS description Proteome description Member of lists (Publications) Other annotations C24G7.2 183713_at C24G7.2; 1E677; CE37320; WBGene00016064; WP:CE37320 Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, list of genes in cluster C, Wang et al 2003 S4 Climbing, Wang et al 2003 S3 genes pass one-way ANOVA, Wang et al 2003 S4 genes pass two-wayANOVA P0 C29F7.2 178316_at C29F7.2; CE35414; WBGene00007811; WP:CE35414; XO35 Reinke et al 2004, list of genes in cluster A, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, mixed sperm soma, Reinke et al 2004, fem3 enriched genes C35D10.14 190499_s_at clec-5; C35D10.14; 3F972; CE27828; WBGene00016450; WP:CE27828 7TM chemoreceptor, clec family C44B7.8 189898_s_at pmp-1; C44B7.8; 2H172; CE02546; NM_063006; WBGene00004058; WP:CE02546 ATP-binding protein Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, list of genes in cluster C, ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S4 Early genes, Wang et al 2003 S3 genes pass one-way ANOVA, Wang et al 2003 S4 genes pass two-wayANOVA P0 C54F6.3 183689_at C54F6.3; 5I11; CE08975; WBGene00016921; WP:CE08975 Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, list of genes in cluster C F01D5.3 178128_at F01D5.3; 2O290; CE18561; WBGene00008494; WP:CE18561 Reinke et al 2004, wt herm vs wt herm enriched gen, ViswanathanM et al 2005 S2 sir-2.1 regulated, ViswanathanM et al 2005 S2 daf-16 Resveratrol F08G5.6 178843_at F08G5.6; 4N201; CE05576; WBGene00008584; WP:CE05576 Murphy et al 2003 Fig2 Class2 shorten lifespan, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, list of genes in cluster C, ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S4 Early genes, Wang et al 2003 S3 genes pass one-way ANOVA, Wang et al 2003 S4 genes pass two-wayANOVA P0 F09B9.2 175840_s_at unc-115; F09B9.2; CE02176; CE15759; NM_077301; WBGene00006839; WP:CE02176; WP:CE15759; XK771 unc-115 encodes a protein that binds actin filaments and that is required for RAS signalling and UNC-40/netrin activity during axon pathfinding. LIM domains McCarroll et al 2004 SFig1-4 conserved w/ Drosoph F15B9.1 193272_s_at far-3; F15B9.1; 5N476; CE09406; NM_073850; WBGene00001387; WP:CE09406 O.volvulus antigen peptide like Murphy et al 2003 Fig2 Class1 elongate lifespan, ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S3 genes pass one-way ANOVA, Wang et al 2003 S4 LateList, Wang et al 2003 S4 genes pass two-wayANOVA P0 F23F12.12 171769_x_at F23F12.12; 3H599; CE29282; WBGene00017756; WP:CE29282 F25D1.5 188921_at F25D1.5; 5L26; CE05726; WBGene00009110; WP:CE05726 This gene encodes a protein predicted by Eisenberg and coworkers, with 68% accuracy, to be mitochondrial. dehydrogenase Kwon et al 2004 T1 late-induction Ethanol-response F31F6.4 175166_at, 187903_at flp-8; F31F6.4; CE05776; CE29960; NM_171805; WBGene00001451; WP:CE05776; WP:CE29960; XP501 flp-8 encodes three copies of a FMRFamide-related short peptide neurotransmitter; although the FLP-8 peptide can increase pharyngeal action potential frequency, loss of FLP-8 function does not result in a mutant phenotype, suggesting that FLP-8 may function redundantly with other FMRFamide-like peptides in the nervous system; FLP-8 expression is detected in embryos and larval stages, but not in adults; FLP-8 is expressed in the sensory neurons ASEL/R, URXL/R, and PVM. Reinke et al 2004, wt herm vs wt herm enriched gen, Reinke et al 2004, IVb male soma enriched genes F35E12.5 179695_at F35E12.5; 5O218; CE38510; WBGene00009429; WP:CE38510 Murphy et al 2003 Fig2 Class2 shorten lifespan, ViswanathanM et al 2005 S2 sir-2.1 regulated F38A6.3 183824_s_at hif-1; F38A6.3; F38A6.3e.1; F38A6.3e.2; 5V253; CE18671; CE18672; CE32019; CE38181; CE38182; NM_075607; WBGene00001851; WP:CE18671; WP:CE18672; WP:CE32019; WP:CE38181; WP:CE38182 hif-1 encodes an ortholog of the mammalian hypoxia-induced factor HIF-1, and is required for survival in hypoxic environments (1% oxygen) that have no effect on wild-type C. elegans. Jiang et al 2001 Fig1 male-enriched TF F42A10.7 186443_at F42A10.7; F42A10.7.1; F42A10.7.2; 3H268; CE01298; WBGene00018343; WP:CE01298 Golden et al 2004, N2 differentially expressed gen, Golden et al 2004, N2 vs daf-2 age different gene, Reinke et al 2004, wt herm vs wt herm enriched gen, ViswanathanM et al 2005 S2 sir-2.1 regulated F54F3.3 187964_at F54F3.3; 5N401; CE18732; WBGene00010062; WP:CE18732 lipase McCarroll et al 2004 SFig5 conserved w/ yeast, ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S6 removed genes of contamination H23N18.3 188962_at ugt-8; H23N18.3; 5F381; CE20985; WBGene00019234; WP:CE20985 7TM chemoreceptor, ugt family Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, fem3 enriched genes, Reinke et al 2004, mixed sperm soma, Reinke et al 2004, list of genes in cluster C, Reinke et al 2004, GO categories, Shen et al 2005 T1 hif-1indepen hypoxia, ViswanathanM et al 2005 S2 daf-16 Resveratrol, ViswanathanM et al 2005 S2 sir-2.1 regulated K07A1.10 182046_at K07A1.10; 1K190; CE39387; WBGene00010616; WP:CE39387 ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S5 genes common to feeding ANOVA, Wang et al 2003 S3 genes pass one-way ANOVA K07E3.8 188031_s_at vem-1; K07E3.8; CE21027; CE34578; WBGene00006890; WP:CE21027; WP:CE34578; XI706 McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Murphy et al 2003 Fig2 Class1 elongate lifespan, ReichertK et al 2005 T1 xenobiotic induced P450, ViswanathanM et al 2005 S2 sir-2.1 regulated K09C4.5 189646_at K09C4.5; CE37126; WBGene00019550; WP:CE37126; XD905 sugar transporter Murphy et al 2003 Fig2 Class1 elongate lifespan, ViswanathanM et al 2005 S2 sir-2.1 regulated K11E8.1 172058_x_at, 175820_s_at, 175821_s_at, 175824_s_at, 187759_s_at, 193459_s_at, 193463_s_at dec-8; unc-43; K11E8.1; K11E8.1a.1; K11E8.1a.2; K11E8.1b.1; K11E8.1b.2; K11E8.1b.3; K11E8.1c.1; K11E8.1c.2; K11E8.1d.1; K11E8.1d.2; K11E8.1e.1; K11E8.1e.2; K11E8.1f.1; K11E8.1f.2; K11E8.1g.1; K11E8.1g.2; K11E8.1h.1; K11E8.1h.2; K11E8.1i.1; K11E8.1i.2; K11E8.1k.1; K11E8.1k.2; K11E8.1l.1; K11E8.1l.2; 4L90; CE28051; CE28052; CE28053; CE28054; CE28055; CE28056; CE28057; CE28058; CE28059; CE28060; CE28061; CE35590; WBGene00006779; WP:CE28051; WP:CE28052; WP:CE28053; WP:CE28054; WP:CE28055; WP:CE28056; WP:CE28057; WP:CE28058; WP:CE28059; WP:CE28060; WP:CE28061; WP:CE35590 unc-43(gf) mutants (in which unc-43 is overexpressed) suppress the excess motoneuron branching, and thus the uncoordinated phenotype, induced by an unc-6deltaC transgene. Ca2+/calmodulin-dependent protein kinase T04C12.3 183970_at T04C12.3; T04C12.3.1; T04C12.3.2; 5L544; CE13146; WBGene00011428; WP:CE13146 Reinke et al 2004, list of genes in cluster A, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, IVb male soma enriched genes, ViswanathanM et al 2005 S2 sir-2.1 regulated T05D4.1 192888_s_at T05D4.1; T05D4.1.1; T05D4.1.2; 3O652; CE16341; WBGene00011474; WP:CE16341 T05D4.1 is orthologous to the human gene ALDOLASE A, FRUCTOSE-BISPHOSPHATE (ALDOA; OMIM:103850), which when mutated leads to aldolase A deficiency. Fructose-bisphosphate aldolase class-I McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, list of genes in cluster C, Reinke et al 2004, wt herm vs wt herm enriched gen, Reinke et al 2004, GO categories, Reinke et al 2004, IVb male soma enriched genes, ViswanathanM et al 2005 S2 sir-2.1 regulated T09H2.1 189343_at cyp-34A4; T09H2.1; 5E427; CE18231; NM_071696; WBGene00020386; WP:CE18231 cytochrome P450 Custodia et al 2001 T2 Cytochrome P450, ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S6 removed genes of contamination T21C12.2 193009_at hpd-1; T21C12.2; 3L625; CE02347; NM_066923; WBGene00001993; WP:CE02347 hpd-1 encodes a 4-hydroxyphenylpyruvate dioxygenase that is required for normally short lifespan and negative regulation of the dauer larval stage, with loss of hpd-1 function prolonging lifespan and promoting dauer formation; hpd-1 is a (perhaps evolutionarily conserved) target of transcriptional activation by DAF-16; HPD-1 is orthologous to human HPD (OMIM:276710, mutated in tyrosinemia type III). 4-hydroxyphenylpyruvate dioxygenase McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Murphy et al 2003 Fig2 Class2 shorten lifespan, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, list of genes in cluster B W03G1.7 192194_s_at asm-3; W03G1.7; 4B274; CE31626; CE39794; NM_067539; WBGene00000213; WP:CE31626; WP:CE39794 sphingomyelin phosphodiesterase Reinke et al 2004, list of genes in cluster A, Reinke et al 2004, list of genes in cluster order, ViswanathanM et al 2005 S2 sir-2.1 regulated, ViswanathanM et al 2005 S2 daf-16 Resveratrol W05G11.6 192581_s_at W05G11.6; W05G11.6a.1; W05G11.6a.2; W05G11.6b.1; W05G11.6b.2; W05G11.6b.3; W05G11.6d.1; W05G11.6d.2; W05G11.6d.3; 3A682; CE14634; CE19610; CE32740; CE32741; WBGene00021043; WP:CE14634; WP:CE19610; WP:CE32740; WP:CE32741 phosphoenolpyruvate carboxykinase Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, list of genes in cluster C, Reinke et al 2004, wt herm vs wt herm enriched gen, ViswanathanM et al 2005 S2 sir-2.1 regulated Y19D10A.4 180813_s_at Y19D10A.4; 5C871; WBGene00021219 Bishop et al 2004 T4 57 vhl-1 depend hif-1 indep, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 sir-2.1 regulated, ViswanathanM et al 2005 S2 daf-16 Resveratrol Y37D8A.23 194006_at unc-25; Y37D8A.23; 3O37; CE20226; CE31832; CE32012; NM_067288; WBGene00006762; WP:CE20226; WP:CE31832; WP:CE32012 Pyridoxal-dependent decarboxylase conserved domain McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, list of genes in cluster A, Reinke et al 2004, list of genes in cluster order Y42G9A.3 184843_at Y42G9A.3; Y42G9A.D; 3H237; CE21870; CE33945; WBGene00021533; WP:CE21870; WP:CE33945 McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, list of genes in cluster A, Reinke et al 2004, list of genes in cluster order, ViswanathanM et al 2005 S2 sir-2.1 regulated Y45G12C.2 187085_s_at gst-10; Y45G12C.2; Y45G12C.M; 5D41; CE21937; NM_071300; WBGene00001758; WP:CE21937 gst-10 encodes a predicted glutathione S-transferase with similarity to human glutathione S-transferase P. glutathione S-transferase Y45G12C.3 186819_s_at Y45G12C.3; Y45G12C.E; 5D31; WBGene00021566 Custodia et al 2001 T2 Glut-S-transferase, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, list of genes in cluster C, Reinke et al 2004, wt herm vs wt herm enriched gen, Wang et al 2003 S3 genes pass one-way ANOVA, Wang et al 2003 S4 Dauer Enriched, Wang et al 2003 S4 genes pass two-wayANOVA P0 Y47D3B.2 185393_s_at nlp-21; Y47D3B.2; 3M478; CE19175; CE24343; NM_067065; NM_067066; WBGene00003759; WP:CE19175; WP:CE24343 nlp-21 encodes nine predicted neuropeptide-like proteins; in C. elegans, nlp-21 is part of the GGARAF neuropeptide family that also contains nlp-9; nlp-21 is expressed in a variety of neurons, including AFD, five head neurons, the ventral nerve cord, one anterior pharyngeal neuron, and one tail neuron; nlp-21 expression is also detected in the embryo and the intestine; as loss of nlp-21 activity via large-scale RNAi screens does not result in any obvious abnormalities, the precise role of nlp-21-encoded peptides in development and/or behavior is not yet known. Reinke et al 2004, IVb male soma enriched genes, ViswanathanM et al 2005 S2 daf-16 Resveratrol, Wang et al 2003 S3 genes pass one-way ANOVA, Wang et al 2003 S4 Dauer Enriched, Wang et al 2003 S4 genes pass two-wayANOVA P0 Y48E1B.8 183850_at Y48E1B.8; 2N877; CE14866; WBGene00013007; WP:CE14866 Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, list of genes in cluster C, Reinke et al 2004, mixed oogenesis soma, Reinke et al 2004, herm soma enriched genes, ViswanathanM et al 2005 S2 sir-2.1 regulated, ViswanathanM et al 2005 S2 daf-16 Resveratrol Y71F9AL.4 192051_at Y71F9AL.4; 1D475; CE25558; WBGene00022110; WP:CE25558 protein-tyrosine phosphatase ZC443.6 191418_at ugt-16; ZC443.6; 5N305; CE06590; WBGene00013901; WP:CE06590 UDP-glucuronosyltransferase ReichertK et al 2005 T1 xenobiotic induced UDP-gl, ViswanathanM et al 2005 S2 daf-16 Resveratrol ZK1058.6 188607_at nit-1; ZK1058.6; 3F11; CE01106; WBGene00014206; WP:CE01106 Nitrilase McCarroll et al 2004 SFig5 conserved w/ yeast, ViswanathanM et al 2005 S2 sir-2.1 regulated ZK525.1 172214_x_at flp-15; ZK525.1; 3O754; CE16731; NM_067419; WBGene00001458; WP:CE16731 flp-15 encodes two FMRFamide-related short peptide neurotransmitter; the precise roles for these peptides in C. elegans neurotransmission are not yet known. ViswanathanM et al 2005 S2 sir-2.1 regulated