Dybbs et al 2005, missense and nonsense genes, 239 genes

Gene list file name:Dybbs2005_ST1_missense_nonsense_genes.txt
Type of gene identifier:Cosmid name
Description:Dybbs2005 et al 2005, Supplymental Table1,List of Missense and Nonsense Alleles  
Organism:Caenorhabditis elegans (nematode)
Gene list type:Experimental

Gene name             Source Gene ID          Annotation                                                  Date       Added by    

B0025.1 vps-34 P W All gene names: let-512; vps-34; B0025.1; B0025.1b.1; B0025.1b.2; B0025.1c.1; B0025.1c.2; B0025.1d.1; B0025.1d.2; 1G609; CE24759; CE24760; CE37691; CE37738; CE37739; NM_059340; WBGene00006932; WP:CE24759; WP:CE24760; WP:CE37691; WP:CE37738; WP:CE37739 WormBase description: The vps-34 gene encodes an ortholog of the phosphoinositide 3-kinase VPS34 in S. cerevisiae, a protein that regulates multiple steps in endocytosis, and that is required for growth at normal rates during development.
                                              
Member of lists (Publications lists):
                                              ViswanathanM et al 2005  S2 sir-2.1                               
                                              regulated, ViswanathanM et al 2005  S2 daf-16                                      
                                              Resveratrol                                                                        

B0261.2 let-363 P W All gene names: CE-TOR; let-363; B0261.2; 1F831; CE32559; CE32560; CeTor; NM_059148; NM_059151; WBGene00002583; WP:CE32559; WP:CE32560 WormBase description: let-363 encodes, by alternative splicing, two large (>2600-residue) proteins with C-terminal similarity to phosphatidylinositol kinase (PIK); LET-363 proteins are orthologous to S. cerevisiae Tor1p and Tor2p and human FRAP1 (OMIM:601231, mammalian target of FKBP12-rapamycin); LET-363 proteins are required for progression through the L3 stage of larval development and are thought to generally stimulate translation of most or all mRNAs ('global translation'); LET-363 activity is also necessary for normal development and physiology of the intestine; LET-363 proteins are expressed ubiquitously, including a maternal contribution to the early embryo.
                                              
Member of lists (Publications lists):
                                              McCarroll et al 2004  SFig5 conserved                             
                                              w/ yeast, McCarroll et al 2004  SFig1-4 conserved w/                               
                                              Drosoph                                                                            

B0273.4 unc-5 P W All gene names: unc-5; B0273.4; 4G260; CE16790; CE37693; NM_068421; NM_068422; WBGene00006745; WP:CE16790; WP:CE37693 WormBase description: unc-5 encodes a netrin receptor; unc-5 activity is required cell autonomously for dorsalward cell and pioneer motor axon migrations along the body wall that are essential for normal locomotion and gonad development; unc-5 mRNAs are expressed throughout the entire life cycle, with increasing levels seen as animals progess to adulthood. WormBase CDS description: axon guidance protein
                                              
Member of lists (Publications lists):
                                              Lund et al 2002  Fig3B neuro-specific                             
                                              genes                                                                              

B0285.5 hse-5 P W All gene names: hse-5; B0285.5; 3F435; CE36681; NM_065475; WBGene00002003; WP:CE36681 WormBase description: hse-5 encodes a D-glucuronyl C5-epimerase.
                                              
Member of lists (Publications lists):
                                              McCarroll et al 2004  SFig1-4                                     
                                              conserved w/ Drosoph, Reinke et al 2004, fem1 enriched                             
                                              genes, Reinke et al 2004, list of genes in cluster                                 
                                              order, Reinke et al 2004, oogenesis enriched genes,                                
                                              Reinke et al 2004, wt vs glp-4 enriched genes, Reinke                              
                                              et al 2004, wt herm vs wt male enriched gen, Reinke et                             
                                              al 2004, list of genes in cluster E, ViswanathanM et al                            
                                              2005  S2 daf-16 Resveratrol, ViswanathanM et al 2005                               
                                              S2 sir-2.1 regulated                                                               

B0334.11 ooc-3 P W All gene names: mel-19; ooc-3; B0334.11; 2L784; CE19661; CE32788; NM_064055; NM_182110; WBGene00003868; WP:CE19661; WP:CE32788 WormBase description: ooc-3 encodes a nematode-specific protein with a predicted signal sequence, four predicted transmembrane domains, and two putative PEST sequences; OOC-3 is probably localized to the endoplasmic reticulum (ER), and is maternally required for correct localization of PAR-2 and PAR-3 in the P1 blastomere of the two-cell stage embryo; specifically, OOC-3 is required for restricting PAR-3 to the anterior cortex of the P1 blastomere to assure PAR-2 localization at the posterior cortex; more generally, OOC-3 is required to establish asymmetrical anterior-posterior cortical domains and spindle orientation in P1.
                                              
Member of lists (Publications lists):
                                              Reinke et al 2004, intrinsic, Reinke                              
                                              et al 2004, wt vs glp-4 enriched genes, Reinke et al                               
                                              2004, list of genes in cluster order, Reinke et al                                 
                                              2004, wt herm vs wt male enriched gen, Reinke et al                                
                                              2004, list of genes in cluster E, ViswanathanM et al                               
                                              2005  S2 sir-2.1 regulated                                                         

B0348.4 egl-8 P W All gene names: egl-8; pbo-2; B0348.4; 5A521; CE30588; CE30589; CE36909; WBGene00001177; WP:CE30588; WP:CE30589; WP:CE36909 WormBase description: egl-8 encodes a phospholipase C beta homolog that affects pharyngeal pumping, defecation, and activity levels; it is genetically downstream of egl-30 with respect to aldicarb-induced paralysis, and is expressed in most or all neurons, with the strongest staining in the head and tail ganglia, and in the intestine.
B0432.5 cat-2 P W All gene names: cat-2; B0432.5; 2A549; CE32103; CE37742; NM_061287; NM_182103; WBGene00000296; WP:CE32103; WP:CE37742 WormBase description: cat-2 encodes a putative tyrosine hydroxylase that affects dopamine levels that in turn affect locomotory slowing in response to food; expressed in dopamanergic as well as other neurons, male spicules, and male ray neurons.
                                              
Member of lists (Publications lists):
                                              McCarroll et al 2004  SFig1-4                                     
                                              conserved w/ Drosoph, Portman et al 2004 T1 10                                     
                                              previously-known ray gene, Romagnolo et al 2002  Fig3b                             
                                              signaling                                                                          

B0545.1 tpa-1 P W All gene names: tpa-1; tpa-1A; tpa-1B; B0545.1; B0545.1b.1; B0545.1b.2; 4A863; CE17353; CE17354; NM_067459; NM_067460; WBGene00006599; WP:CE17353; WP:CE17354 WormBase description: protein kinase C
C01B12.1 sqt-2 P W All gene names: sqt-2; C01B12.1; 2A315; CE07789; NM_061234; WBGene00005017; WP:CE07789 WormBase description: Uncloned locus that affects alae formation and body morphology such that mutants exhibit a slightly dumpy phenotype and the bodies of mutants are helically twisted. WormBase CDS description: cuticular collagen
                                              
Member of lists (Publications lists):
                                              Jones et al 2001  Non dauer genes                                 
                                              P<0.05, Reinke et al 2004, list of genes in cluster                                
                                              order, Reinke et al 2004, list of genes in cluster B,                              
                                              ViswanathanM et al 2005  S2 sir-2.1 regulated,                                     
                                              ViswanathanM et al 2005  S2 daf-16 Resveratrol, Wang et                            
                                              al 2003  S3  genes pass one-way ANOVA, Wang et al 2003                             
                                              S4 LateList, Wang et al 2003  S4 genes pass                                        
                                              two-wayANOVA P0                                                                    

C01B7.6 rpm-1 P W All gene names: rpm-1; rpm-3; sad-3; sam-1; syd-3; C01B7.6; 5J282; CE06730; NM_072866; WBGene00004457; WP:CE06730
                                              
Member of lists (Publications lists):
                                              McCarroll et al 2004  SFig1-4                                     
                                              conserved w/ Drosoph, ViswanathanM et al 2005  S2                                  
                                              sir-2.1 regulated, ViswanathanM et al 2005  S2 daf-16                              
                                              Resveratrol                                                                        

C01F6.5 ref-1 P W All gene names: aly-1; ref-1; C01F6.5; 4J873; CE02954; NM_069187; WBGene00000120; WP:CE02954 WormBase description: RNA recognition motif. (aka RRM, RBD, or RNP domain)
                                              
Member of lists (Publications lists):
                                              Jones et al 2001  Non dauer genes                                 
                                              P<0.05, Reinke et al 2004, fem1 enriched genes, Reinke                             
                                              et al 2004, mixed oogenesis soma, Romagnolo et al 2002                             
                                              Fig3b Metabolism, ViswanathanM et al 2005  S2 sir-2.1                              
                                              regulated, ViswanathanM et al 2005  S2 daf-16                                      
                                              Resveratrol                                                                        

C01G6.8 cam-1 P W All gene names: cam-1; kin-8; C01G6.8; 2J586; CE24774; CE32563; CE39126; WBGene00000289; WP:CE24774; WP:CE32563; WP:CE39126 WormBase description: The cam-1 gene encodes a receptor tyrosine kinase of the immunoglobulin superfamily that is orthologous to human ROR1 (OMIM:602336) and ROR2 (OMIM:602337, mutation of which leads to type B brachydactyly) and is required for locomotion, cell migration, asymmetric cell division, axon outgrowth, and dauer formation; CAM-1 is broadly expressed during embryogenesis and larval development with expression first appearing at the 200-cell stage of embryogenesis.
                                              
Member of lists (Publications lists):
                                              McCarroll et al 2004  SFig1-4                                     
                                              conserved w/ Drosoph, Reinke et al 2004, fem1 enriched                             
                                              genes, Reinke et al 2004, mixed oogenesis soma,                                    
                                              ViswanathanM et al 2005  S2 sir-2.1 regulated,                                     
                                              ViswanathanM et al 2005  S2 daf-16 Resveratrol                                     

C02B8.4 hlh-8 P W All gene names: hlh-8; C02B8.4; CE24777; NM_076966; WBGene00001953; WP:CE24777; XI737 WormBase description: The hlh-8 gene encodes a helix-loop-helix protein required for normal muscle development, and hence for normal defecation and egg-laying. WormBase CDS description: MYC family of helix-loop-helix transcription factors
                                              
Member of lists (Publications lists):
                                              McCarroll et al 2004  SFig1-4                                     
                                              conserved w/ Drosoph, ViswanathanM et al 2005  S2                                  
                                              sir-2.1 regulated, ViswanathanM et al 2005  S2 daf-16                              
                                              Resveratrol                                                                        

C02C6.1 dyn-1 P W All gene names: dyn-1; C02C6.1; CE07832; CE07833; WBGene00001130; WP:CE07832; WP:CE07833; XQ191; dyn1 WormBase description: dynamin
                                              
Member of lists (Publications lists):
                                              McCarroll et al 2004  SFig1-4                                     
                                              conserved w/ Drosoph                                                               

C02F4.2 tax-6 P W All gene names: cna-1; pph-3; pph2B-A; tax-6; C02F4.2; 4L258; CE07853; CE33593; PP2B; WBGene00006527; WP:CE07853; WP:CE33593 WormBase description: tax-6 encodes an ortholog of calcineurin A that is required for inhibition and adaptation of several sensory neurons and for the normal regulation of egg-laying by serotonin; TAX-6 stimulates transcription of rcn-1, and binds RCN-1 protein if free Ca[2+] is present; in general, calcineurin positively regulates calcium-dependent signaling.
                                              
Member of lists (Publications lists):
                                              Jones et al 2001  Dauer specific genes                            
                                              P<0.05, McCarroll et al 2004  SFig5 conserved w/ yeast,                            
                                              McCarroll et al 2004  SFig1-4 conserved w/ Drosoph,                                
                                              Reinke et al 2004, list of genes in cluster order,                                 
                                              Reinke et al 2004, list of genes in cluster B,                                     
                                              ViswanathanM et al 2005  S2 sir-2.1 regulated, Wang et                             
                                              al 2003  S7 SAGE genes in the dataset, Wang et al 2003                             
                                              S8 SAGE genes in the dauer exit                                                    

C03B8.4 lin-13 P W All gene names: lin-13; lin-51; C03B8.4; 3I790; CE30419; NM_066277; WBGene00003002; WP:CE30419 WormBase description: Gene Function : lin-13 encodes a large (2248-residue) nuclear protein with multiple zinc fingers of the C2H2 class and a LXCXE retinoblastoma protein-binding motif, that is required for survival through larval development and for negative regulation of vulval fates during postembryonic development. WormBase CDS description: Zinc finger
                                              
Member of lists (Publications lists):
                                              Reinke et al 2004, list of genes in                               
                                              cluster F, Reinke et al 2004, list of genes in cluster                             
                                              order                                                                              

C04F5.1 sid-1 P W All gene names: rsd-8; sid-1; C04F5.1; 5F603; CE30331; NM_071971; WBGene00004795; WP:CE30331 WormBase description: The sid-1 gene encodes a predicted transmembrane protein with conserved human (OMIM:606816) and mouse homologs of unknown function and is required cell autonomously for systemic RNA interference (RNAi); a SID-1::GFP fusion is enriched at the cell periphery of most nonneuronal cells from late embryogenesis through adulthood with highest levels detected in cells exposed to the environment.
                                              
Member of lists (Publications lists):
                                              Murphy et al 2003  Fig2 Class2 shorten                            
                                              lifespan, Reinke et al 2004, list of genes in cluster                              
                                              F, Reinke et al 2004, fem1 enriched genes, Reinke et al                            
                                              2004, list of genes in cluster order, Reinke et al                                 
                                              2004, wt herm vs wt male enriched gen, Reinke et al                                
                                              2004, mixed oogenesis soma, ViswanathanM et al 2005  S2                            
                                              sir-2.1 regulated                                                                  

C04F6.4 unc-78 P W All gene names: unc-78; C04F6.4; C04F6.4b.1; C04F6.4b.2; CE03924; CE33554; NM_076189; WBGene00006810; WP:CE03924; WP:CE33554; XE28 WormBase description: The unc-78 gene encodes a homolog of actin-interacting protein 1 (AIP1) that regulates the ordered assembly of actin and cofilin in myofibrils.
                                              
Member of lists (Publications lists):
                                              McCarroll et al 2004  SFig5 conserved                             
                                              w/ yeast, Wang et al 2003  S5 genes common to feeding                              
                                              ANOVA, Wang et al 2003  S3  genes pass one-way ANOVA                               

C05B10.1 lip-1 P W All gene names: lip-1; C05B10.1; 4H607; CE31151; NM_068652; WBGene00003043; WP:CE31151 WormBase description: protein-tyrosine phosphatase
                                              
Member of lists (Publications lists):
                                              McCarroll et al 2004  SFig1-4                                     
                                              conserved w/ Drosoph, Reinke et al 2004, list of genes                             
                                              in cluster F, Reinke et al 2004, fem1 enriched genes,                              
                                              Reinke et al 2004, wt vs glp-4 enriched genes, Reinke                              
                                              et al 2004, list of genes in cluster order, Reinke et                              
                                              al 2004, oogenesis enriched genes, ViswanathanM et al                              
                                              2005  S2 sir-2.1 regulated                                                         

C05D2.4 bas-1 P W All gene names: bas-1; C05D2.4; 3G703; CE01141; CE37081; WBGene00000239; WP:CE01141; WP:CE37081 WormBase description: bas-1 encodes a serotonin- and dopamine-synthetic aromatic amino acid decarboxylase (AAADC) that is required for the synthesis of serotonin from 5-hydroxytryptophan in vivo; mutations of bas-1 impair the turning step in male mating, the migration of AVM, SDQR, ALM, and BDU neurons during development. WormBase CDS description: aromatic-L-amino-acid decarboxylase
                                              
Member of lists (Publications lists):
                                              Jones et al 2001  Non dauer genes                                 
                                              P<0.05, Reinke et al 2004, list of genes in cluster                                
                                              order, Reinke et al 2004, list of genes in cluster C,                              
                                              ViswanathanM et al 2005  S2 sir-2.1 regulated,                                     
                                              ViswanathanM et al 2005  S2 daf-16 Resveratrol, Wang et                            
                                              al 2003  S5 genes common to feeding ANOVA, Wang et al                              
                                              2003  S3  genes pass one-way ANOVA                                                 

C07B5.5 nuc-1 P W All gene names: nuc-1; C07B5.5; CE00895; NM_077203; WBGene00003828; WP:CE00895; XK159 WormBase description: The nuc-1 gene encodes a DNase II homolog similar to mammalian and Drosophila DNaseII enzymes and is required for DNA degradation during apoptosis as well as for degradation of dietary DNA during normal feeding; during apoptosis, NUC-1 functions in apoptotic cells at an intermediate stage of DNA degradation, after the killing step, but prior to cell-corpse engulfment.
                                              
Member of lists (Publications lists):
                                              Golden et al 2004, daf-2                                          
                                              differentially expressed , McCarroll et al 2004                                    
                                              SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005                              
                                              S2 sir-2.1 regulated                                                               

C09E10.2 dgk-1 P W All gene names: dgk-1; sag-1; C09E10.2; CE08038; CE08039; CE38268; CE38269; CE38270; NM_075789; NM_075790; WBGene00000958; WP:CE08038; WP:CE08039; WP:CE38268; WP:CE38269; WP:CE38270; XB604 WormBase description: The dgk-1 gene encodes an ortholog of diacylglyerol kinase that affects movement, egg laying, and synaptic transmission; it genetically interacts with the goa-1 and egl-30 signaling pathways, and is expressed in neurons.
C09G12.8 ced-10 P W All gene names: ced-10; C09G12.8; 4E272; CE16832; CE16833; NM_067961; WBGene00000424; WP:CE16832; WP:CE16833; rac1 WormBase description: ced-10 encodes a GTPase orthologous to human RAC1 (OMIM:602048) that is required for phagocytosis during programmed cell death and for migration of the distal tip cells of the somatic gonad; CED-10 functions in the engulfing cell during apoptosis, and is activated by a complex of CED-2(CrkII) and CED-5(DOCK180) to promote formation of the polarized cell extensions associated with cell corpse engulfment. WormBase CDS description: RAS-related protein
C09G9.6 oma-1 P W All gene names: moe-1; oma-1; C09G9.6; C09G9.6.1; C09G9.6.2; 4J655; CE03005; NM_069141; WBGene00003864; WP:CE03005 WormBase description: The oma-1 gene encodes a zinc finger protein of the TIS11 finger type that is paralogous to OMA-2; while either oma-1 or oma-2 individually have no obvious mutant phenotype, a normal copy of at least one of these genes is required for oocyte maturation. WormBase CDS description: Zinc finger protein
                                              
Member of lists (Publications lists):
                                              Reinke et al 2004, fem1 enriched                                  
                                              genes, Reinke et al 2004, Fig2b shared gemlines, Reinke                            
                                              et al 2004, list of genes in cluster order, Reinke et                              
                                              al 2004, oogenesis enriched genes, Reinke et al 2004,                              
                                              wt vs glp-4 enriched genes, Reinke et al 2004, wt males                            
                                              vs glp4 male enriched , Reinke et al 2004, wt herm vs                              
                                              wt male enriched gen, Reinke et al 2004, GO categories,                            
                                              Reinke et al 2004, list of genes in cluster E,                                     
                                              ViswanathanM et al 2005  S2 sir-2.1 regulated, Wang et                             
                                              al 2003  S6 removed genes of contamination                                         

C09H6.1 spr-4 P W All gene names: spr-4; C09H6.1; 1I685; CE15609; CE30487; WBGene00005009; WP:CE15609; WP:CE30487 WormBase description: Zinc finger, C2H2 type (11 domains)
                                              
Member of lists (Publications lists):
                                              Reinke et al 2004, list of genes in                               
                                              cluster order, ViswanathanM et al 2005  S2 sir-2.1                                 
                                              regulated                                                                          

C09H6.2 lin-10 P W All gene names: lin-10; C09H6.2; 1I686; CE15610; CE27060; NM_059825; WBGene00002999; WP:CE15610; WP:CE27060 WormBase description: The lin-10 gene encodes a PDZ and PTB domain-containing protein that is homologous to mammalian Munc interacting proteins (Mint1, OMIM:602414) and is required for polarized protein localization; LIN-10 is required for proper localization of the LET-23 EGF receptor to the basolateral membrane of the vulval precursor cells and for proper postsynaptic localization of GLR-1, an AMPA-type glutamate receptor in interneurons; LIN-10 is detected in the cytoplasm, membrane, and at particularly high levels in the Golgi. WormBase CDS description: Phosphotyrosine interaction domain (PTB/PID)., PDZ domain (Also known as DHR or GLGF). (2 domains)
C10H11.9 let-502 P W All gene names: let-502; C10H11.9; 1F308; CE08098; NM_059039; WBGene00002694; WP:CE08098 WormBase description: let-502 encodes a Rho-binding Ser/Thr kinase orthologous to human myotonic dystrophy kinase (DM-kinase); let-502 is required for early embryonic cleavages, embryonic elongation, migration of hypodermal P cells to a ventral position, normal spermathecal contraction, and fertility; LET-502 is required for hypodermal cells to properly change their shape, and is expressed in those cells, during embryonic elongation; let-502 mutations are suppressed by mel-11 mutations, and the pattern of LET-502 expression in the embryonic epidermis and the spermatheca is opposite to that of MEL-11, indicating that LET-502 and MEL-11 have opposing functions (presumably tissue contraction and relaxation); MEL-11 requires LET-502 (along with the nonmuscle myosin NMY-1) for proper localization. WormBase CDS description: Rho-associated kinase
                                              
Member of lists (Publications lists):
                                              McCarroll et al 2004  SFig1-4                                     
                                              conserved w/ Drosoph, Reinke et al 2004, list of genes                             
                                              in cluster F, Reinke et al 2004, list of genes in                                  
                                              cluster order, ViswanathanM et al 2005  S2 daf-16                                  
                                              Resveratrol                                                                        

C12D8.10 akt-1 P W All gene names: akt-1; akt-1a; akt-1b; C12D8.10; C12D8.10b.1; C12D8.10b.2; 5K731; CE05274; CE15612; CE31304; WBGene00000102; WP:CE05274; WP:CE15612; WP:CE31304 WormBase description: akt-1 encodes an ortholog of serine/threonine kinase Akt/PKB; akt-1 genetically interacts with the insulin signaling pathway and is widely expressed; two alleles of akt-1 (sa573 and sa700) have a Daf-c mutant phenotype at 27 degrees C (Hid phenotype).
                                              
Member of lists (Publications lists):
                                              Reinke et al 2004, wt herm vs wt male                             
                                              enriched gen, ViswanathanM et al 2005  S2 sir-2.1                                  
                                              regulated, Wang et al 2003  S3  genes pass one-way                                 
                                              ANOVA, Wang et al 2003  S4 Dauer Enriched, Wang et al                              
                                              2003  S4 genes pass two-wayANOVA P0                                                

C14C11.6 mut-14 P W All gene names: mut-14; C14C11.6; 5G140; CE06825; NM_072089; WBGene00003507; WP:CE06825 WormBase description: mut-14 mutants exhibit germline transposon activation, a deficient response to RNAi, resistance to co-suppression, and transgene desilencing. WormBase CDS description: helicase
                                              
Member of lists (Publications lists):
                                              Lund et al 2002   Fig3C                                           
                                              Germline-intrinsic, Reinke et al 2004, list of genes in                            
                                              cluster F, Reinke et al 2004, fem1 enriched genes,                                 
                                              Reinke et al 2004, list of genes in cluster order,                                 
                                              Reinke et al 2004, oogenesis enriched genes, Reinke et                             
                                              al 2004, wt vs glp-4 enriched genes, Reinke et al 2004,                            
                                              wt herm vs wt male enriched gen, Reinke et al 2004, GO                             
                                              categories, ViswanathanM et al 2005  S2 sir-2.1                                    
                                              regulated                                                                          

C14F5.5 sem-5 P W All gene names: sem-5; C14F5.5; CE01784; NM_076941; WBGene00004774; WP:CE01784; XI578 WormBase description: sem-5 encodes a Src homology (SH) domain 2 and 3-containing protein, orthologous to human GRB2 (OMIM:108355), that functions in multiple signaling pathways during development; these pathways include those regulating sex myoblast migration, vulval induction, fluid balance, viability, and formation of the male tail; SEM-5 acts downstream of the LET-23 epidermal growth factor receptor to negatively regulate RAS-MAP-, as well as IP-3-, mediated signal transduction. WormBase CDS description: C. elegans sem-5
                                              
Member of lists (Publications lists):
                                              McCarroll et al 2004  SFig5 conserved                             
                                              w/ yeast, McCarroll et al 2004  SFig1-4 conserved w/                               
                                              Drosoph, Reinke et al 2004, fem1 enriched genes, Reinke                            
                                              et al 2004, mixed oogenesis soma, ViswanathanM et al                               
                                              2005  S2 sir-2.1 regulated                                                         

C15A11.3 sol-1 P W All gene names: sol-1; C15A11.3; C15A11.3.1; C15A11.3.2; 1H966; CE36685; NM_059687; WBGene00004944; WP:CE36685 WormBase description: CUB domain
                                              
Member of lists (Publications lists):
                                              Wang et al 2003  S4 Early genes, Wang                             
                                              et al 2003  S3  genes pass one-way ANOVA, Wang et al                               
                                              2003  S4 genes pass two-wayANOVA P0                                                

C15B12.7 cdf-1 P W All gene names: cdf-1; C15B12.7; CE27065; CE29581; NM_076694; NM_076695; WBGene00000393; WP:CE27065; WP:CE29581; XH114 WormBase description: a cation diffusion facilitator protein, affects vulva development, genetically interacts with let-60/ras signaling pathway; and is expressed in the vulval muscles, the intestinal cells, and in the vulval precursor cells.
                                              
Member of lists (Publications lists):
                                              McCarroll et al 2004  SFig5 conserved                             
                                              w/ yeast, McCarroll et al 2004  SFig1-4 conserved w/                               
                                              Drosoph, ViswanathanM et al 2005  S2 sir-2.1 regulated                             

C16C2.2 eat-16 P W All gene names: eat-16; sag-2; C16C2.2; C16C2.2a.1; C16C2.2a.2; 1K301; CE17404; CE30491; NM_170911; NM_170912; WBGene00001145; WP:CE17404; WP:CE30491 WormBase description: The eat-16 gene encodes an RGS protein that affects movement, pharyngeal pumping, egg laying, and synaptic transmission; it genetically interacts with the egl-30 and goa-1 signaling pathways, and is expressed in excitable cells and in the spermatheca. WormBase CDS description: regulator of G-protein signalling
                                              
Member of lists (Publications lists):
                                              McCarroll et al 2004  SFig1-4                                     
                                              conserved w/ Drosoph, ViswanathanM et al 2005  S2                                  
                                              daf-16 Resveratrol                                                                 

C18A11.7 dim-1 P W All gene names: dim-1; C18A11.7; C18A11.7b.1; C18A11.7b.2; C18A11.7b.3; C18A11.7b.4; CE04038; CE27706; WBGene00001000; WP:CE04038; WP:CE27706; XI670
                                              
Member of lists (Publications lists):
                                              Link et al 2003  T2 Abeta repressed,                              
                                              Reinke et al 2004, list of genes in cluster order,                                 
                                              Reinke et al 2004, list of genes in cluster C                                      

C18E9.11 ooc-5 P W All gene names: ooc-5; C18E9.11; 2J283; CE28283; CE28284; NM_063515; NM_063516; WBGene00003870; WP:CE28283; WP:CE28284
C24A3.6 twk-18 P W All gene names: mah-2; twk-18; unc-110; C24A3.5; C24A3.6; C24A3.6.1; C24A3.6.2; CE24811; WBGene00006672; WP:CE24811; XJ611 WormBase description: twk-18 encodes one of 44 C. elegans TWK (two-P domain K+) potassium channel subunits that contain two pore-forming domains and four transmembrane domains; TWK-18 was originally defined by gain-of-function mutations that result in embryonic lethality at the two-fold stage, locomotion defects, longer than normal body length, abnormal egg-laying, and temperature-sensitive paralysis; as loss of TWK-18 function via reversion or RNA-mediated interference does not result in any abnormalities, TWK-18 likely functions redundantly with other TWK channels; TWK-18 can function as an outwardly rectifying K+ channel, and is activated by temperature increases, thus making it a temperature-gated channel; TWK-18 is expressed in body wall muscle. WormBase CDS description: potassium channel protein
                                              
Member of lists (Publications lists):
                                              Jiang et al 2001  Fig1 male-enriched                              
                                              neuronal, Reinke et al 2004, list of genes in cluster                              
                                              order, Reinke et al 2004, list of genes in cluster B,                              
                                              ViswanathanM et al 2005  S2 daf-16 Resveratrol                                     

C24G6.1 syp-2 P W All gene names: syp-2; C24G6.1; 5G17; CE17456; NM_072061; WBGene00006376; WP:CE17456
                                              
Member of lists (Publications lists):
                                              Reinke et al 2004, fem1 enriched                                  
                                              genes, Reinke et al 2004, wt vs glp-4 enriched genes,                              
                                              Reinke et al 2004, list of genes in cluster order,                                 
                                              Reinke et al 2004, oogenesis enriched genes, Reinke et                             
                                              al 2004, wt herm vs wt male enriched gen, Reinke et al                             
                                              2004, list of genes in cluster E, ViswanathanM et al                               
                                              2005  S2 sir-2.1 regulated                                                         

C26C6.2 goa-1 P W All gene names: goa-1; C26C6.2; 1I101; CE05311; NM_059707; WBGene00001648; WP:CE05311 WormBase description: The goa-1 gene encodes an ortholog of the heterotrimeric G protein alpha subunit Go (Go/Gi class) that affects normal locomotion, egg-laying, and male mating; it genetically interacts with the egl-30 pathway, and is expressed in all neurons and sex-specific muscles. WormBase CDS description: guanine nucleotide-binding protein
                                              
Member of lists (Publications lists):
                                              McCarroll et al 2004  SFig5 conserved                             
                                              w/ yeast, McCarroll et al 2004  SFig1-4 conserved w/                               
                                              Drosoph, Reinke et al 2004, fem1 enriched genes, Reinke                            
                                              et al 2004, mixed oogenesis soma, ViswanathanM et al                               
                                              2005  S2 sir-2.1 regulated                                                         

C26D10.5 eff-1 P W All gene names: eff-1; elf-1; C26D10.5; 2I639; CE03028; CE30881; CE31159; CE32594; WBGene00001159; WP:CE03028; WP:CE30881; WP:CE31159; WP:CE32594 WormBase description: The eff-1 gene encodes a novel, type I transmembrane glycoprotein that is required for cell fusion during development; eff-1(hy21) mutants are viable, but have severe body morphology defects associated with cell fusion failure.
                                              
Member of lists (Publications lists):
                                              Reinke et al 2004, list of genes in                               
                                              cluster order, Reinke et al 2004, list of genes in                                 
                                              cluster B, ViswanathanM et al 2005  S2 sir-2.1                                     
                                              regulated, ViswanathanM et al 2005  S2 daf-16                                      
                                              Resveratrol, Wang et al 2003  S4 Climbing, Wang et al                              
                                              2003  S3  genes pass one-way ANOVA, Wang et al 2003  S4                            
                                              genes pass two-wayANOVA P0                                                         

C26E6.5 fsn-1 P W All gene names: fsn-1; C26E6.5; 3G27; CE01163; NM_065645; WBGene00001499; WBGene00016141; WP:CE01163 WormBase description: This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins
                                              
Member of lists (Publications lists):
                                              McCarroll et al 2004  SFig1-4                                     
                                              conserved w/ Drosoph, Reinke et al 2004, fem1 enriched                             
                                              genes, Reinke et al 2004, Fig2b shared gemlines, Reinke                            
                                              et al 2004, list of genes in cluster order, Reinke et                              
                                              al 2004, oogenesis enriched genes, Reinke et al 2004,                              
                                              wt vs glp-4 enriched genes, Reinke et al 2004, wt males                            
                                              vs glp4 male enriched , Reinke et al 2004, wt herm vs                              
                                              wt male enriched gen, Reinke et al 2004, list of genes                             
                                              in cluster E, ViswanathanM et al 2005  S2 sir-2.1                                  
                                              regulated                                                                          

C29F9.7 pat-4 P W All gene names: pat-4; C29F9.7; C29F9.7.1; C29F9.7.2; 3A708; CE19706; NM_064738; WBGene00003931; WP:CE19706 WormBase description: The pat-4 gene encodes a serine/threonine kinase orthologous to human integrin-linked kinase (ILK, OMIM:602366) and is required for formation of integrin-mediated muscle cell attachments during embryogenesis; PAT-4 probably functions as an adaptor molecule and localizes to dense bodies and M lines; PAT-4 forms a ternary complex with PAT-6/actopaxin and UNC-112, and requires UNC-112, UNC-52/perlecan, PAT-2/alpha integrin, and PAT-3/beta integrin for proper localization to newly forming integrin adhesion complexes. WormBase CDS description: integrin-linked kinase
                                              
Member of lists (Publications lists):
                                              McCarroll et al 2004  SFig1-4                                     
                                              conserved w/ Drosoph, Reinke et al 2004, list of genes                             
                                              in cluster order, Reinke et al 2004, list of genes in                              
                                              cluster C, Roy et al 2002  S2 positivecontrol L1 muscle                            

C30D11.1 unc-103 P W All gene names: unc-103; C30D11.1; 3F235; CE27805; NM_065423; WBGene00006830; WP:CE27805 WormBase description: unc-103 encodes an ERG-like K+ channel homolog, orthologous to human KCNH6 (OMIM:608168); UNC-103 regulates muscle activation in motility, egg-laying and male spicule protraction; UNC-103 is expressed highly in many neurons; gain-of-function alleles can be uncoordinated, while loss-of-function alleles have a more subtle defect in copulatory spicule protraction. WormBase CDS description: potassium channel protein
                                              
Member of lists (Publications lists):
                                              McCarroll et al 2004  SFig1-4                                     
                                              conserved w/ Drosoph, ViswanathanM et al 2005  S2                                  
                                              sir-2.1 regulated                                                                  

C32A3.1 sel-8 P W All gene names: lag-3; pqn-17; sel-8; C32A3.1; C32A3.1b.1; C32A3.1b.2; 3E704; CE01505; CE27810; WBGene00004765; WP:CE01505; WP:CE27810 WormBase description: sel-8 encodes a nuclear protein required for LIN-12 and GLP-1 signalling; SEL-8 contains a novel motif shared with W09C5.1 and orthologs of W09C5.1 in S. cerevisiae (YER126c), Drosophila (DMIP259), and also has two prominent glutamine-rich domains.
C32C4.5 mab-23 P W All gene names: mab-23; C32C4.5; 5L115; CE31427; NM_171536; WBGene00003114; WP:CE31427 WormBase description: mab-23 encodes a DNA binding transcription factor of the DM (DOUBLESEX/MAB-3) class that is required for morphogenesis of the posterior hypodermis, spicules, and proctodeum in male tails, for the patterning of posterior male sensory neurons, and for normal turning during male mating; mab-23 interacts with egl-5 and with a TGF-beta-related signaling pathway, while having functions independent of mab-3.
C33D9.1 exc-5 P W All gene names: Cefgd-1; exc-5; fgd-1; C33D9.1; C33D9.1b.1; C33D9.1b.2; 4J564; CE30498; CE30499; WBGene00001366; WP:CE30498; WP:CE30499 WormBase description: The exc-5 gene encodes a homolog of human FGD1, which when mutated leads to Aarskog-Scott syndrome (OMIM:305400). WormBase CDS description: PH (pleckstrin homology) domain
                                              
Member of lists (Publications lists):
                                              ViswanathanM et al 2005  S2 sir-2.1                               
                                              regulated, ViswanathanM et al 2005  S2 daf-16                                      
                                              Resveratrol                                                                        

C36B7.7 hen-1 P W All gene names: hen-1; C36B7.7; CE04178; NM_076799; WBGene00001841; WP:CE04178; XH732 WormBase description: hen-1 encodes a secretory protein that contains a low-density lipoprotein receptor class A domain and affects integration of sensory stimuli and behavioral plasticity; expressed in pharyngeal muscles, the vulva, and is weakly expressed in a subset of neurons.
                                              
Member of lists (Publications lists):
                                              ViswanathanM et al 2005  S2 sir-2.1                               
                                              regulated, Wang et al 2003  S3  genes pass one-way                                 
                                              ANOVA, Wang et al 2003  S4 Dauer Enriched, Wang et al                              
                                              2003  S4 genes pass two-wayANOVA P0                                                

C36E8.5 tbb-2 P W All gene names: rot-2; tbb-2; C36E8.5; C36E8.5.1; C36E8.5.2; C36E8.5.3; 3F106; CE00913; NM_065405; TUBB8; WBGene00006537; WP:CE00913 WormBase description: tbb-2 encodes a homolog of mammalian beta-tubulin (TUBB) that is expressed at high levels in the germline; TBB-2 is redundant for embryonic viability, due to its paralog TBB-1; however, unlike its paralog TBB-1 it is preferred for normal microtubule severing by the katanin complex MEI-1/MEI-2; TBB-2 is required together with TBB-1, TBA-1, and tba-2 to make spindle structures in embryos and TBB-2 also affects the stability of the PO spindle; first divisions are normal in null mutants, but putative gain-of-function mutations affect centrosome rotations in the P0, P1, and EMS blastomeres of the early embryo, and affect pronuclear migration and meiosis. WormBase CDS description: beta tubulin
                                              
Member of lists (Publications lists):
                                              ViswanathanM et al 2005  S2 sir-2.1                               
                                              regulated                                                                          

C36H8.2 inx-6 P W All gene names: inx-6; opu-6; C36H8.2; 4N513; CE24831; NM_070034; WBGene00002128; WP:CE24831 WormBase description: inx-6 encodes an innexin, an integral transmembrane channel protein that is a structural component of invertebrate gap junctions; INX-6 is required for formation of pharyngeal gap junctions and thus for the electrical coupling and synchronous muscle contractions necessary for normal feeding behavior and postembryonic development; INX-6 may function redundantly with EAT-5, another C. elegans innexin; INX-6 expression is first detected in embryonic pharyngeal precursors and during later larval and adult stages, in pharyngeal corpus muscles and isthmus marginal cells, where INX-6 localizes to plaque-like structures in the plasma membrane. WormBase CDS description: UNC-7 like
                                              
Member of lists (Publications lists):
                                              ViswanathanM et al 2005  S2 daf-16                                
                                              Resveratrol, Wang et al 2003  S4 Climbing, Wang et al                              
                                              2003  S3  genes pass one-way ANOVA, Wang et al 2003  S4                            
                                              genes pass two-wayANOVA P0                                                         

C37A2.4 cye-1 P W All gene names: cye-1; evl-10; C37A2.4; 1H359; CE24832; CE33761; NM_059540; WBGene00000871; WP:CE24832; WP:CE33761 WormBase description: cye-1 encodes a homolog of the G1 cell cycle regulator cyclin E; CYE-1 is required for progression through the G1 phase of the cell cycle and for endoreduplication in intestinal cells, and is required maternally both for embryonic development and for the proper execution of several post-embryonic lineages (e.g. vulval development); CYE-1 is provided maternally and expressed ubiquitously in nuclei during embryonic development; postembryonic expression is restricted to actively proliferating blast cells, including the germline.
                                              
Member of lists (Publications lists):
                                              Jiang et al 2001  Fig2 cyclin-genes,                              
                                              McCarroll et al 2004  SFig1-4 conserved w/ Drosoph,                                
                                              Reinke et al 2004, fem1 enriched genes, Reinke et al                               
                                              2004, list of genes in cluster order, Reinke et al                                 
                                              2004, oogenesis enriched genes, Reinke et al 2004, wt                              
                                              vs glp-4 enriched genes, Reinke et al 2004, list of                                
                                              genes in cluster E, ViswanathanM et al 2005  S2 sir-2.1                            
                                              regulated                                                                          

C37A5.9 pry-1 P W All gene names: pry-1; C37A5.9; 1O766; CE30125; NM_061073; WBGene00004202; WP:CE30125
                                              
Member of lists (Publications lists):
                                              Reinke et al 2004, list of genes in                               
                                              cluster order, Reinke et al 2004, list of genes in                                 
                                              cluster B                                                                          

C37E2.4 ceh-36 P W All gene names: ceh-36; C37E2.4; CE08623; NM_077964; WBGene00000457; WP:CE08623; XO802 WormBase description: ceh-36 encodes a paired-like homeodomain transcription factor that is one of three orthodenticle (OTD)-like homeodomain proteins in C. elegans (the others being ttx-1 and ceh-37); CEH-36 is required broadly for specification of the AWC olfactory neuron and also for establishing the left-right asymmetry of the ASEL and ASER gustatory neurons; in addition, CEH-36 is sufficient to specify the AFD thermosensory neuron fate in some cell types; CEH-36 is expressed in the AWC and ASE chemosensory neurons. WormBase CDS description: Homeobox domain
C37E2.5 ceh-37 P W All gene names: ceh-37; C37E2.5; CE08624; NM_077965; WBGene00000458; WP:CE08624; XO816 WormBase description: ceh-37 encodes one of three C. elegans proteins with an OTX-like homeodomain; however, CEH-37 lacks other domains found in OTX proteins, and the CEH-37 homeodomain is predicted to resemble the Myb domain of telomere-binding proteins; CEH-37 binds the telomeric sequence 'TTAGGC' if it is repeated at least 1.5 times, and is mainly localized to the telomere in vivo; ceh-37 mutants have a weak increase in chromosomal nondisjunction; CEH-37 is involved in specifying some aspects of the AWB olfactory neuron fate, such as expression of an AWB-specific odorant receptor and a LIM-class homeodomain protein, LIM-4; CEH-37 is expressed broadly in the early embryo, while in larvae and adults it is expressed solely in the excretory cell. WormBase CDS description: Homeobox domain
                                              
Member of lists (Publications lists):
                                              ViswanathanM et al 2005  S2 sir-2.1                               
                                              regulated                                                                          

C37F5.1 lin-1 P W All gene names: lin-1; C37F5.1; C37F5.1.1; C37F5.1.2; 4D42; CE31440; WBGene00002990; WP:CE31440 WormBase description: lin-1 encodes an Ets-domain-containing transcription factor that is a member of the ETS gene family that includes human ELK1, 3, and 4 (OMIM:600247); LIN-1 functions as a general effector of MAP kinase-mediated signaling; when MAP kinase is inactive, LIN-1 forms a complex with LIN-31/WH that inhibits vulval cell fate specification; upon MAP kinase activation (vulval induction), LIN-1 is phosphorylated, dissociates from LIN-31, and becomes inactive, thus allowing for vulval development.
                                              
Member of lists (Publications lists):
                                              Reinke et al 2004, list of genes in                               
                                              cluster order, Reinke et al 2004, list of genes in                                 
                                              cluster B                                                                          

C39E6.6 npr-1 P W All gene names: bor-1; npr-1; C39E6.6; CE06941; NM_076415; WBGene00003807; WP:CE06941; XF386 WormBase description: npr-1 encodes a predicted G protein-coupled neuropeptide receptor that is homologous to the mammalian neuropeptide Y (NPY) receptor (OMIM:162641) required for regulating anxiety, food consumption, and pain sensation; in C. elegans, NPR-1 is involved in ethological variations of social behavior such as social versus solitary feeding; NPR-1 also affects some aspect of UNC-6/netrin-mediated branching of motor neurons, as strong npr-1 mutations can suppress abnormal migration of ventral nerve cord neurons induced by overexpression of UNC-6 lacking domain C; NPR-1 is expressed predominantly in the nervous system, and particularly in the AQR, PQR, and URX neurons that are exposed to the body fluid. WormBase CDS description: G-protein coupled receptor
C40H5.5 ttx-3 P W All gene names: ttx-3; C40H5.5; CE27107; NM_077569; WBGene00006654; WP:CE27107; XM384 WormBase description: ttx-3 encodes a LIM homeodomain protein required for functions of the thermosensory interneuron AIY, including olfactory learning. WormBase CDS description: LIM domain containing proteins (2 domains), homeobox protein (lim subfamily)
C42C1.11 ap-1 P W All gene names: AP-1; C42C1.11; C42C1.11a.1; C42C1.11a.2; C42C1.11c.1; C42C1.11c.2; 4N45; CE24840; CE33564; CE33565; WBGene00016589; WP:CE24840; WP:CE33564; WP:CE33565 WormBase description: peptidase
                                              
Member of lists (Publications lists):
                                              McCarroll et al 2004  SFig5 conserved                             
                                              w/ yeast, McCarroll et al 2004  SFig1-4 conserved w/                               
                                              Drosoph, ViswanathanM et al 2005  S2 sir-2.1 regulated                             

C44H4.7 eor-2 P W All gene names: eor-2; C44H4.7; CE31445; CE31446; WBGene00001325; WP:CE31445; WP:CE31446; XP225 WormBase description: eor-2 encodes an unfamiliar protein, similar to CG17233 in Drosophila and KIAA1205 in H. sapiens, required for signal transduction by both RAS and Wnt pathways in both excretory system development and P12 fate specification.
                                              
Member of lists (Publications lists):
                                              ViswanathanM et al 2005  S2 sir-2.1                               
                                              regulated, ViswanathanM et al 2005  S2 daf-16                                      
                                              Resveratrol                                                                        

C48D1.2 ced-3 P W All gene names: ced-3; C48D1.2; 4N964; CE29088; NM_070137; WBGene00000417; WP:CE29088 WormBase description: The ced-3 gene encodes a protease required for apoptosis. WormBase CDS description: Caspase recruitment domain, ICE-like protease (caspase) p20 domain., ICE-like protease (caspase) p10 domain.
                                              
Member of lists (Publications lists):
                                              McCarroll et al 2004  SFig1-4                                     
                                              conserved w/ Drosoph                                                               

C51E3.7 egl-3 P W All gene names: egl-3; kpc-2; C51E3.7; C51E3.7a.1; C51E3.7a.2; C51E3.7b.1; C51E3.7b.2; 5K650; CE08940; CE08941; NM_073213; WBGene00001172; WP:CE08940; WP:CE08941; pc2 WormBase description: The egl-3 gene encodes a homolog of a mammalian proprotein convertase that participates in peptide secretion. WormBase CDS description: prohormone convertase 2
C53A5.3 hda-1 P W All gene names: gon-10; hda-1; C53A5.3; C53A5.3.1; C53A5.3.2; 5P7; CE08952; NM_074198; WBGene00001834; WP:CE08952 WormBase description: The hda-1 gene encodes a histone deacetylase 1, similar to histone deacetylases RPD3 from yeast and fly; maternal and zygotic expression of hda-1 is required for embryonic viability, and zygotic expression of hda-1 is also required for gonadogenesis and vulval development. WormBase CDS description: Yeast RPD3 protein like
                                              
Member of lists (Publications lists):
                                              McCarroll et al 2004  SFig5 conserved                             
                                              w/ yeast, McCarroll et al 2004  SFig1-4 conserved w/                               
                                              Drosoph, Reinke et al 2004, list of genes in cluster F,                            
                                              Reinke et al 2004, fem1 enriched genes, Reinke et al                               
                                              2004, list of genes in cluster order, Reinke et al                                 
                                              2004, oogenesis enriched genes, Reinke et al 2004, wt                              
                                              vs glp-4 enriched genes, Reinke et al 2004, wt herm vs                             
                                              wt male enriched gen, ViswanathanM et al 2005  S2                                  
                                              sir-2.1 regulated                                                                  

C55B7.12 che-1 P W All gene names: che-1; tax-1; tax-5; C55B7.12; 1H94; CE34280; NM_059476; WBGene00000483; WP:CE34280 WormBase description: che-1 encodes a C2H2-type zinc finger-containing transcription factor orthologous to Drosophila GLASS, which is required for photoreceptor cell differentiation; CHE-1 is required for determining the identity and function of the amphid ASE neurons, the major neurons that mediate chemotaxis to water-soluble attractants; CHE-1 is expressed predominantly in the ASE neurons and regulates, either directly or indirectly, the expression of a number of ASE-specific genes. WormBase CDS description: zinc finger prtoein
                                              
Member of lists (Publications lists):
                                              McCarroll et al 2004  SFig5 conserved                             
                                              w/ yeast, McCarroll et al 2004  SFig1-4 conserved w/                               
                                              Drosoph                                                                            

C56G2.6 let-767 P W All gene names: dhs-10; let-767; C56G2.6; C56G2.6.1; C56G2.6.2; 3H428; CE30639; NM_065985; WBGene00002891; WP:CE30639 WormBase description: let-767 encodes a short-chain dehydrogenase, reported to be required for efficient cholesterol metabolism; LET-767 is predicted to be required for the metabolism of a sterol and to be mitochondrial.
                                              
Member of lists (Publications lists):
                                              McCarroll et al 2004  SFig5 conserved                             
                                              w/ yeast, McCarroll et al 2004  SFig1-4 conserved w/                               
                                              Drosoph, ViswanathanM et al 2005  S2 sir-2.1 regulated,                            
                                              Wang et al 2003  S4 Climbing, Wang et al 2003  S3                                  
                                              genes pass one-way ANOVA, Wang et al 2003  S4 genes                                
                                              pass two-wayANOVA P0                                                               

CC4.3 smu-1 P W All gene names: smu-1; CC4.3; CC4.3.1; CC4.3.2; CC4.3.3; 1N595; CE15742; NM_060878; WBGene00004895; WP:CE15742 WormBase description: WD domain, G-beta repeats (2 domains)
                                              
Member of lists (Publications lists):
                                              McCarroll et al 2004  SFig1-4                                     
                                              conserved w/ Drosoph, ViswanathanM et al 2005  S2                                  
                                              sir-2.1 regulated                                                                  

D1014.8 spr-1 P W All gene names: spr-1; D1014.8; 5I608; CE27749; NM_072697; WBGene00005006; WP:CE27749
                                              
Member of lists (Publications lists):
                                              Reinke et al 2004, intrinsic, Reinke                              
                                              et al 2004, wt vs glp-4 enriched genes, Reinke et al                               
                                              2004, list of genes in cluster order, Reinke et al                                 
                                              2004, wt herm vs wt male enriched gen, Reinke et al                                
                                              2004, list of genes in cluster E, ViswanathanM et al                               
                                              2005  S2 sir-2.1 regulated                                                         

D2030.10 aex-1 P W All gene names: aex-1; D2030.10; 1I183; CE30740; CE30741; NM_170901; WBGene00000084; WP:CE30740; WP:CE30741 WormBase description: AEX-1 is a novel C2 domain protein; C2 is a proposed calcium binding domain; AEX-1 is weakly similar to the rat protein Munc13, which regulates vesicle exocytosis; AEX-1 regulates UNC-13 localization; mutation of dgk-1, or a gain-of-function mutation of egl-30, suppresses the aex-1 mutant phenotype.
                                              
Member of lists (Publications lists):
                                              Reinke et al 2004, herm soma enriched                             
                                              genes, ViswanathanM et al 2005  S2 sir-2.1 regulated,                              
                                              Wang et al 2003  S4 Early genes, Wang et al 2003  S3                               
                                              genes pass one-way ANOVA, Wang et al 2003  S4 genes                                
                                              pass two-wayANOVA P0                                                               

D2096.4 sqv-1 P W All gene names: sqv-1; D2096.4; D2096.4.1; D2096.4.2; 4J127; CE04302; NM_069017; WBGene00005019; WP:CE04302 WormBase description: sqv-1 encodes a UDP-glucuronic acid decarboxylase, biochemically active in vitro, that is required for cytokinesis of one-cell embryos and for vulval morphogenesis; SQV-1 is coexpressed with the nucleotide-sugar transporter homolog SQV-7 in in the vulva and in oocytes; SQV-1 colocalizes with SQV-5 and SQV-7 to punctate foci (probably the Golgi apparatus) in the cytoplasm of the vulva, the uterus and oocytes, within which SQV-1 may act to promote the biosynthesis of chondroitin glycosaminoglycans; the common requirement for SQV-1 in both cytokinesis and morphogenesis may be to promote filling an extracellular space with hygroscopic proteoglycans (either in the eggshell, or underneath the L4 cuticle), which in turn may cause the space to fill with fluid.
                                              
Member of lists (Publications lists):
                                              McCarroll et al 2004  SFig1-4                                     
                                              conserved w/ Drosoph, McElwee et al 2003  T1 targets of                            
                                              daf-16, Reinke et al 2004, list of genes in cluster                                
                                              order, Reinke et al 2004, intrinsic, Reinke et al 2004,                            
                                              wt vs glp-4 enriched genes, Reinke et al 2004, wt herm                             
                                              vs wt male enriched gen, Reinke et al 2004, GO                                     
                                              categories, Reinke et al 2004, herm soma enriched                                  
                                              genes, Reinke et al 2004, list of genes in cluster E,                              
                                              ViswanathanM et al 2005  S2 sir-2.1 regulated, Wang et                             
                                              al 2003  S5 genes common to feeding ANOVA, Wang et al                              
                                              2003  S3  genes pass one-way ANOVA                                                 

F01D4.4 egl-21 P W All gene names: egl-21; F01D4.4; F01D4.4.1; F01D4.4.2; F01D4.4.3; F01D4.4.4; F01D4.4.5; F01D4.4.6; 4L244; CE09156; NM_069534; WBGene00001189; WP:CE09156 WormBase description: Uncloned locus that affects egg laying. WormBase CDS description: zinc carboxypeptidase
F02A9.6 glp-1 P W All gene names: emb-33; glp-1; F02A9.6; 3K187; CE00237; NM_066613; WBGene00001609; WP:CE00237 WormBase description: glp-1 encodes an N-glycosylated transmembrane protein that, along with LIN-12, comprises one of two C. elegans members of the LIN-12/Notch family of receptors; from the N- to the C-terminus, GLP-1 is characterized by ten extracellular EGF-like repeats, three LIN-12/Notch repeats, a CC-linker, a transmembrane domain, a RAM domain, six intracellular ankyrin repeats, and a PEST sequence; in C. elegans, GLP-1 activity is required for cell fate specification in germline and somatic tissues; in the germline, GLP-1, acting as a receptor for the DSL family ligand LAG-2, is essential for mitotic proliferation of germ cells and maintenance of germline stem cells; in somatic tissues, maternally provided GLP-1, acting as a receptor for the DSL family ligand APX-1, is required for inductive interactions that specify the fates of certain embryonic blastomeres; GLP-1 is also required for some later embryonic cell fate decisions, and in these decisions its activity is functionally redundant with that of LIN-12; GLP-1 expression is regulated temporally and spatially via translational control, as GLP-1 mRNA, present ubiquitously in the germline and embryo, yields detectable protein solely in lateral, interior, and endomembranes of distal, mitotic germ cells, and then predominantly in the AB blastomere and its descendants in the early embryo; proper spatial translation of glp-1 mRNA in the embryo is dependent upon genes such as the par genes, that are required for normal anterior-posterior asymmetry in the early embryo; signaling through GLP-1 controls the activity of the downstream Notch pathway components LAG-3 and LAG-1, the latter being predicted to function as part of a transcriptional feedback mechanism that positively regulates GLP-1 expression; signaling through the DNA-binding protein LAG-1 is believed to involve a direct interaction between LAG-1 and the GLP-1 RAM and ankyrin domains WormBase CDS description: GLP-1 protein
                                              
Member of lists (Publications lists):
                                              Reinke et al 2004, list of genes in                               
                                              cluster F, Reinke et al 2004, fem1 enriched genes,                                 
                                              Reinke et al 2004, wt vs glp-4 enriched genes, Reinke                              
                                              et al 2004, list of genes in cluster order, Reinke et                              
                                              al 2004, oogenesis enriched genes, Reinke et al 2004,                              
                                              wt herm vs wt male enriched gen, ViswanathanM et al                                
                                              2005  S2 sir-2.1 regulated                                                         

F10C5.1 mat-3 P W All gene names: apc-8; mat-3; pod-4; vex-2; F10C5.1; F10C5.1.1; F10C5.1.2; 3B99; CE26888; NM_064802; WBGene00003134; WBGene00006909; WP:CE26888
                                              
Member of lists (Publications lists):
                                              McCarroll et al 2004  SFig5 conserved                             
                                              w/ yeast, McCarroll et al 2004  SFig1-4 conserved w/                               
                                              Drosoph, Reinke et al 2004, list of genes in cluster F,                            
                                              Reinke et al 2004, Fig2b shared gemlines, Reinke et al                             
                                              2004, list of genes in cluster order, Reinke et al                                 
                                              2004, intrinsic, Reinke et al 2004, wt vs glp-4                                    
                                              enriched genes, Reinke et al 2004, wt males vs glp4                                
                                              male enriched , Reinke et al 2004, wt herm vs wt male                              
                                              enriched gen, ViswanathanM et al 2005  S2 sir-2.1                                  
                                              regulated, Wang et al 2003  S5 genes common to feeding                             
                                              ANOVA, Wang et al 2003  S3  genes pass one-way ANOVA                               

F11H8.1 rfl-1 P W All gene names: cyk-5; rfl-1; uba-3; F11H8.1; 3I113; CE34538; NM_066133; WBGene00004341; WP:CE34538 WormBase description: rfl-1 (also known as cyk-5) encodes an ortholog of UBA3, a Nedd8 activating enzyme for ubiquitin-like proteins, which is required for proper cytokinesis and spindle orientation; NED-8 is presumably activated by an ULA-1/RFL-1 heterodimer. WormBase CDS description: ubiquitin-activating enzyme
                                              
Member of lists (Publications lists):
                                              McCarroll et al 2004  SFig5 conserved                             
                                              w/ yeast, McCarroll et al 2004  SFig1-4 conserved w/                               
                                              Drosoph, Reinke et al 2004, list of genes in cluster                               
                                              order, Reinke et al 2004, wt herm vs wt male enriched                              
                                              gen, Reinke et al 2004, list of genes in cluster E,                                
                                              ViswanathanM et al 2005  S2 daf-16 Resveratrol,                                    
                                              ViswanathanM et al 2005  S2 sir-2.1 regulated,                                     
                                              ViswanathanM et al 2005 S2 Resveratrol regulate WT                                 

F15A2.6 sad-1 P W All gene names: sad-1; F15A2.6; CE28218; NM_077852; WBGene00004719; WP:CE28218; XO108 WormBase description: sad-1 encodes a novel serine/threonine protein kinase; SAD-1 activity is required for several aspects of presynaptic development, including termination of axon outgrowth and presynaptic vesicle clustering, in GABAergic motor neurons and the ASI amphid chemosensory neuron; in addition, overexpression studies suggest that SAD-1 may also play a role in regulating axonal-dendritic polarity; SAD-1 is expressed in the nervous system, where it localizes asymmetrically to the synapse-rich regions of axons. WormBase CDS description: serine/threonine kinase (KIN1/SNF1/Nim1 subfamily)
                                              
Member of lists (Publications lists):
                                              McCarroll et al 2004  SFig5 conserved                             
                                              w/ yeast, McCarroll et al 2004  SFig1-4 conserved w/                               
                                              Drosoph, Reinke et al 2004, list of genes in cluster A,                            
                                              Reinke et al 2004, list of genes in cluster order                                  

F15C11.1 sem-4 P W All gene names: sem-4; F15C11.1; F15C11.1.1; F15C11.1.2; 1H623; CE17673; NM_059596; WBGene00004773; WP:CE17673 WormBase description: Zinc finger, C2H2 type (7 domains)
                                              
Member of lists (Publications lists):
                                              McCarroll et al 2004  SFig1-4                                     
                                              conserved w/ Drosoph, ViswanathanM et al 2005  S2                                  
                                              daf-16 Resveratrol                                                                 

F17C8.1 acy-1 P W All gene names: acy-1; sgs-1; F17C8.1; 3F819; CE00955; NM_065569; WBGene00000068; WP:CE00955 WormBase description: The acy-1 gene encodes a protein with 40% identity to mammalian adenylyl cyclases, most closely related to the divergent mouse isoform type IX, that affects viability, muscle contraction, locomotion, and molting; it acts genetically downstream of gsa-1 and is expressed in excitable cells. WormBase CDS description: adenylate cyclase
                                              
Member of lists (Publications lists):
                                              McCarroll et al 2004  SFig1-4                                     
                                              conserved w/ Drosoph, ViswanathanM et al 2005  S2                                  
                                              daf-16 Resveratrol                                                                 

F18A1.2 lin-26 P W All gene names: lin-26; F18A1.2; F18A1.2.1; F18A1.2.2; F18A1.2.3; 2H973; CE27972; WBGene00003012; WP:CE27972 WormBase description: lin-26 encodes a putative C2H2 zinc finger-containing protein required for proper differentiation of ectodermal and mesodermal epithelial cells; LIN-26 is expressed in many different cell types including the rectal rep cells, the somatic gonad, glial cells, and hypodermal cells; ectopic LIN-26 expression during embryogenesis induces epithelial-like cell fates suggesting that LIN-26 is sufficient for epithelial differentiation. WormBase CDS description: transcription factor
                                              
Member of lists (Publications lists):
                                              Baugh et al 2005, PAL-1 target genes,                             
                                              Reinke et al 2004, intrinsic, Reinke et al 2004, wt vs                             
                                              glp-4 enriched genes, ViswanathanM et al 2005  S2                                  
                                              sir-2.1 regulated                                                                  

F18C12.1 che-3 P W All gene names: avr-1; caf-2; che-3; che-8; osm-2; F18C12.1; 1I638; CE32386; NM_059820; WBGene00000485; WP:CE32386 WormBase description: The dynein heavy chain (DHC) 1b isoform that affects the establishment and maintainance of the structural integrity of sensory cilia and also has a role in intraflagellar transport; it is expressed in ciliated sensory neurons. WormBase CDS description: dynein heavy chain
                                              
Member of lists (Publications lists):
                                              McCarroll et al 2004  SFig1-4                                     
                                              conserved w/ Drosoph, ViswanathanM et al 2005  S2                                  
                                              sir-2.1 regulated, ViswanathanM et al 2005  S2 daf-16                              
                                              Resveratrol                                                                        

F18E2.3 scc-3 P W All gene names: scc-3; F18E2.3; 5N247; CE05664; NM_073792; WBGene00004738; WP:CE05664 WormBase description: scc-3 encodes a cohesin complex subunit homologous to Saccharomyces cerevisiae Irr1p/Scc3p; SCC-3 is required during meiosis for synaptonemal complex formation and sister chromatid cohesion, proper localization of REC-8 to chromosomes, mitotic chromosome segregation, embryonic development, and vulval morphogenesis; in embryos, SCC-3 forms a cohesin complex with SCC-1, SMC-1, SMC-3, and TIM-1, a HEAT/Armadillo repeat-containing protein related to Drosophila TIMELESS; in the germline, SCC-3 associates with chromatin of transistion zone nuclei, assembles along the longitudinal axes of synapsed chromosomes at pachytene, and unlike other cohesins, localizes throughout chromatin at diakinesis; SCC-3 localization requires TIM-1, and SCC-3 and REC-8 are mutually required for chromatin localization.
                                              
Member of lists (Publications lists):
                                              McCarroll et al 2004  SFig1-4                                     
                                              conserved w/ Drosoph, Reinke et al 2004, intrinsic,                                
                                              Reinke et al 2004, list of genes in cluster F, Reinke                              
                                              et al 2004, wt vs glp-4 enriched genes, Reinke et al                               
                                              2004, list of genes in cluster order, Reinke et al                                 
                                              2004, wt herm vs wt male enriched gen, ViswanathanM et                             
                                              al 2005  S2 sir-2.1 regulated                                                      

F18H3.5 cdk-4 P W All gene names: cdk-4; F18H3.5; CE18608; CE28918; NM_077855; WBGene00000406; WP:CE18608; WP:CE28918; XO136 WormBase description: cdk-4 encodes two isoforms of a cyclin-dependent serine/threonine protein kinase orthologous to human CDK4 and CDK6 (OMIM:123829 and OMIM:603368, mutated in cutanous malignant melanoma) which complex with D-type cyclins to regulate progression through the G1 phase of the cell cycle; CDK-4 activity is essential for G1 progression in postembryonic blast cells and as a result, cdk-4 mutant animals generally arrest during larval stages; the lethality generated by cdk mutations, also seen in animals doubly mutant for cdk-4 and cyd-1, a C. elegans D-type cyclin, can be suppressed by mutations in lin-35/Rb suggesting that, as in other organisms, LIN-35/Rb may be a major target of CDK-4/CYD-1 kinase activity; CDK-4 expression is first detected in neuronal and hypodermal lineages during mid-to-late embryogenesis, with postembryonic expression detected in hypodermal seam cells, cells of the P lineage which will give rise to ventral cord neurons, and cells of the somatic gonad, the vulva, and the intestine. WormBase CDS description: serine/threonine kinase (CDC2/CDKX subfamily)
                                              
Member of lists (Publications lists):
                                              Reinke et al 2004, fem1 enriched                                  
                                              genes, Reinke et al 2004, mixed oogenesis soma, Reinke                             
                                              et al 2004, wt herm vs wt male enriched gen,                                       
                                              ViswanathanM et al 2005  S2 daf-16 Resveratrol,                                    
                                              ViswanathanM et al 2005  S2 sir-2.1 regulated, Wang et                             
                                              al 2003  S3  genes pass one-way ANOVA, Wang et al 2003                             
                                              S4 Climbing, Wang et al 2003  S4 genes pass                                        
                                              two-wayANOVA P0                                                                    

F21F3.5 unc-38 P W All gene names: tmr-2; unc-38; F21F3.5; 1F466; CE24908; NM_059071; WBGene00006774; WP:CE24908 WormBase description: unc-38 encodes a nicotinic acetylcholine receptor (nAChR) alpha subunit; UNC-38 is required for normal locomotion and egg-laying, and functions as a subunit of a ligand-gated ion channel that likely mediates fast actions of acetylcholine at neuromuscular junctions and in the nervous system; when coexpressed with UNC-29 and LEV-1, non-alpha nAChR subunits, the resulting multimer can form levamisole-gated channels; UNC-38 is expressed postsynaptically in muscles and neurons where it colocalizes with TAX-6, and with ACR-8, ACR-12, and UNC-29, respectively. WormBase CDS description: ligand-gated ionic channel
                                              
Member of lists (Publications lists):
                                              McCarroll et al 2004  SFig1-4                                     
                                              conserved w/ Drosoph, Murphy et al 2003  Fig2 Class1                               
                                              elongate lifespan, Reinke et al 2004, list of genes in                             
                                              cluster A, Reinke et al 2004, list of genes in cluster                             
                                              order, ViswanathanM et al 2005  S2 sir-2.1 regulated                               

F21H12.5 fbf-2 P W All gene names: fbf-2; F21H12.5; 2G380; CE01916; NM_062819; WBGene00001402; WP:CE01916 WormBase description: fbf-2 encodes an RNA-binding protein that is one of 11 C. elegans members of the PUF family (Pumilio and FBF) of translational regulators; FBF-2 is nearly identical to FBF-1 with which it is largely redundant in regulating two aspects of germline development: 1)maintenance of stem cell proliferation, and 2)the hermaphroditic switch between spermatogenesis and oogenesis; in maintaining germline stem cells, the FBF proteins, acting through NOS-3, negatively regulate the activity of gld-1 mRNA, which encodes a translational repressor required for meiotic entry; in regulating the sperm-to-oocyte switch, the FBFs act downstream of GLD-3 to negatively regulate the activity of fem-3 mRNA, which encodes a novel protein required for germline sex determination; consistent with their role in germline development, FBF-1 and FBF-2 are expressed in the germline cytoplasm, becoming enriched in the mitotic region during the L4 larval and adult stages.
                                              
Member of lists (Publications lists):
                                              Reinke et al 2004, intrinsic, Reinke                              
                                              et al 2004, Fig2b shared gemlines, Reinke et al 2004,                              
                                              wt vs glp-4 enriched genes, Reinke et al 2004, wt males                            
                                              vs glp4 male enriched                                                              

F22B5.1 evl-20 P W All gene names: arf-2; evl-20; F22B5.1; 2I735; ARF/2; CE27425; NM_063378; WBGene00001358; WP:CE27425 WormBase description: evl-20 encodes a functional ortholog of human ADP-ribosylation factor-like protein 2 (ARL2; OMIM:601175), with evl-20(ar103) mutants being rescued by transgenic human ARL2 but not ARL1 or ARL3-7; EVL-20 is required for cortical microtubule formation during cytokinesis and morphogenesis; EVL-20 is required for vulval, gonadal, and male tail development, as well as for embryonic mitosis, hypodermal enclosure, and elongation; EVL-20 is expressed in migrating hypodermal embryonic cells, larval vulval and somatic gonad cells, larval and adult neurons, and adult male proctodeal cells, being subcellularly associated with both the cell cortex and astral microtubules. WormBase CDS description: GTP-binding ADP-ribosylation factor
                                              
Member of lists (Publications lists):
                                              McCarroll et al 2004  SFig1-4                                     
                                              conserved w/ Drosoph, Reinke et al 2004, intrinsic,                                
                                              Reinke et al 2004, wt vs glp-4 enriched genes, Reinke                              
                                              et al 2004, list of genes in cluster order, Reinke et                              
                                              al 2004, list of genes in cluster E, ViswanathanM et al                            
                                              2005  S2 sir-2.1 regulated                                                         

F22B7.10 dpy-19 P W All gene names: dpy-19; F22B7.10; 3J750; CE26462; NM_066508; WBGene00001078; WP:CE26462 WormBase description: The dpy-19 gene encodes a novel transmembrane protein whose human homolog is expressed in brain, and that is required for correct polarization and migration of the neuroblasts QL and QR.
                                              
Member of lists (Publications lists):
                                              McCarroll et al 2004  SFig1-4                                     
                                              conserved w/ Drosoph, Reinke et al 2004, list of genes                             
                                              in cluster order, Reinke et al 2004, list of genes in                              
                                              cluster B, ViswanathanM et al 2005  S2 sir-2.1                                     
                                              regulated, Wang et al 2003  S4 Climbing, Wang et al                                
                                              2003  S3  genes pass one-way ANOVA, Wang et al 2003  S4                            
                                              genes pass two-wayANOVA P0                                                         

F22F4.2 inx-3 P W All gene names: inx-3; opu-3; F22F4.2; F22F4.2.1; F22F4.2.2; CE33055; NM_076601; WBGene00002125; WP:CE33055; XG615 WormBase description: unc-7-like protein
                                              
Member of lists (Publications lists):
                                              Reinke et al 2004, intrinsic, Reinke                              
                                              et al 2004, wt vs glp-4 enriched genes, Reinke et al                               
                                              2004, list of genes in cluster order, Reinke et al                                 
                                              2004, wt herm vs wt male enriched gen, Reinke et al                                
                                              2004, list of genes in cluster E, ViswanathanM et al                               
                                              2005  S2 sir-2.1 regulated, ViswanathanM et al 2005  S2                            
                                              daf-16 Resveratrol                                                                 

F26A3.3 ego-1 P W All gene names: ego-1; ego-6; F26A3.3; 1I228; CE27140; NM_059731; WBGene00001214; WP:CE27140 WormBase description: The ego-1 gene encodes a homolog of RNA-directed RNA polymerase that is essential for germ-line development.
                                              
Member of lists (Publications lists):
                                              Reinke et al 2004, intrinsic, Reinke                              
                                              et al 2004, wt vs glp-4 enriched genes, Reinke et al                               
                                              2004, list of genes in cluster order, Reinke et al                                 
                                              2004, list of genes in cluster E                                                   

F26D11.11 let-413 P W All gene names: let-413; F26D11.11; 5I454; CE29778; CE37008; NM_072650; WBGene00002632; WP:CE29778; WP:CE37008 WormBase description: let-413 encodes a protein with strong similarity to human ERBIN, rat DENSIN, Drosophila SCRIB and its human ortholog hSCRIB; LET-413 protein is localized to the basolateral region of epithelial cells, and is required for the assembly of adherens junctions.
                                              
Member of lists (Publications lists):
                                              McCarroll et al 2004  SFig1-4                                     
                                              conserved w/ Drosoph, ViswanathanM et al 2005  S2                                  
                                              sir-2.1 regulated                                                                  

F26F12.7 let-418 P W All gene names: chd-4; evl-11; let-418; F26F12.7; 5G311; CE17716; NM_072122; WBGene00002637; WP:CE17716 WormBase description: The let-418 gene encodes a homolog of Mi-2/CHD3, a component of the nucleosome remodeling and histone deacetylase (NURD) complex; LET-418 is similar to DNA helicases, homologous to human AIRE (OMIM:607358, mutated in autoimmune polyendocrinopathy syndrome), and paralogous to CHD-3; with MEP-1, LET-418 is required to repress germline-specific genes in somatic cells, and also negatively regulates RAS-dependent postembryonic vulval development (via the synMuvB pathway); LET-418 and CHD-3 are redundantly required for specification of secondary cell fates in vulval development; LET-418 is expressed in all interphase nuclei throughout development; LET-418 is bound by MEP-1, and also interacts with HDA-1 and PIE-1; these interactions probably reflect repression of LET-418 by PIE-1 in the germline. WormBase CDS description: DNA helicase
                                              
Member of lists (Publications lists):
                                              Reinke et al 2004, intrinsic, Reinke                              
                                              et al 2004, wt vs glp-4 enriched genes, Reinke et al                               
                                              2004, wt herm vs wt male enriched gen, ViswanathanM et                             
                                              al 2005  S2 sir-2.1 regulated                                                      

F27D9.1 unc-18 P W All gene names: lan-2; unc-18; unc-19; F27D9.1; F27D9.1a.1; F27D9.1a.2; CE04449; CE24927; CE34004; NM_076897; WBGene00006757; WP:CE04449; WP:CE24927; WP:CE34004; XI303 WormBase description: unc-18 encodes an ortholog of Saccharomyces cervisiae SEC1 that enables the docking of vesicles to synaptic regions before vesicle priming and fusion, and thus promotes synaptic vesicle exocytosis; UNC-18 may also inhibit excessive exocytosis.
                                              
Member of lists (Publications lists):
                                              McCarroll et al 2004  SFig5 conserved                             
                                              w/ yeast, McCarroll et al 2004  SFig1-4 conserved w/                               
                                              Drosoph, ViswanathanM et al 2005  S2 sir-2.1 regulated                             

F28F9.1 zag-1 P W All gene names: zag-1; F28F9.1; F28F9.1.1; F28F9.1.2; 4E625; CE34546; NM_068023; WBGene00006970; WP:CE34546 WormBase description: zag-1 encodes a homeodomain protein of the ZFH class which consists of a homeodomain flanked by two clusters of C2H2-type zinc fingers and is related to transcriptional repressors encoded by Drosophila zfh-1 and the vertebrate ZEB genes; ZAG-1 is required for locomotion, for neuronal differentiation, and for proper axonal branching and fasciculation; from late embryogenesis through adult stages of development, ZAG-1 is expressed dynamically in head and tail neurons and in the intestinal and anal depressor muscles. WormBase CDS description: zinc-finger homeodomain protein
                                              
Member of lists (Publications lists):
                                              Jones et al 2001  Non dauer genes                                 
                                              P<0.05, McCarroll et al 2004  SFig1-4 conserved w/                                 
                                              Drosoph                                                                            

F29F11.1 sqv-4 P W All gene names: sqv-4; F29F11.1; F29F11.1.1; F29F11.1.2; 5L140; CE05767; NM_073329; WBGene00005022; WP:CE05767 WormBase description: sqv-4 encodes a UDP-glucose 6-dehydrogenase, biochemically active in vitro, that is required for cytokinesis of one-cell embryos and for vulval morphogenesis; SQV-4 is orthologous to Drosophila SUGARLESS, human UGDH (OMIM:603370), and zebrafish JEKYLL; SQV-4 is expressed in many cell types, notably oocytes and uterine, seam, pharyngeal, and spermathecal cells, with expression being prominent in 14 of the 22 vulval nuclei of late L4 larvae; the common requirement for SQV-4 in both cytokinesis and morphogenesis may be to promote filling an extracellular space with hygroscopic proteoglycans (either in the eggshell, or underneath the L4 cuticle), which in turn may cause the space to fill with fluid. WormBase CDS description: UDP-glucose dehydrogenase
                                              
Member of lists (Publications lists):
                                              McCarroll et al 2004  SFig1-4                                     
                                              conserved w/ Drosoph, ViswanathanM et al 2005  S2                                  
                                              sir-2.1 regulated                                                                  

F32G8.6 cat-4 P W All gene names: cat-4; F32G8.6; 5L45; CE05795; NM_073309; WBGene00000298; WP:CE05795 WormBase description: cat-4 encodes an ortholog of the human GTP cyclohydrolase I gene (GCH1; OMIM:600225), which when mutated leads to dystonia; CAT-4 is involved in serotonin and dopamine biosynthesis that affects movement, mating behavior, foraging behavior, and cell migration; CAT-4 acts in the same genetic pathway as flp-1. WormBase CDS description: GTP cyclohydrolase I
                                              
Member of lists (Publications lists):
                                              McCarroll et al 2004  SFig5 conserved                             
                                              w/ yeast, McCarroll et al 2004  SFig1-4 conserved w/                               
                                              Drosoph, ViswanathanM et al 2005  S2 sir-2.1 regulated                             

F34D10.5 lin-48 P W All gene names: lin-48; F34D10.5; 3E835; CE24940; NM_065358; WBGene00003033; WP:CE24940 WormBase description: lin-48 encodes a C2H2-type zinc-finger transcription factor that is orthologous to Drosophila OVO and mouse OVO1; LIN-48 is required for development of the hindgut, the male tail, and the excretory duct cell; in hindgut and male tail development, LIN-48 activity is essential for proper fate specification of the U, F, and K' blast cells and B blast cell descendants, and in excretory duct cell development, for normal duct cell morphogenesis; a LIN-48 translational reporter is expressed in the nuclei of the U, F, K, and K' blast cells, the excretory duct cell, and up to 10 cells in the head region beginning in late embryogenesis and continuing through adulthood; in addition, expression is detected in the neuronal support cells of the phasmid and labial sensory structures beginning at the late L1 larval stage; in hindgut cell specification, LIN-48 functions with EGL-38/Pax, which appears to be a direct transcriptional regulator of LIN-48 expression, and in excretory duct cell development, LIN-48 is likely under the control of the CES-2 bZip transcription factor WormBase CDS description: Zinc finger, C2H2 type (3 domains)
                                              
Member of lists (Publications lists):
                                              McCarroll et al 2004  SFig1-4                                     
                                              conserved w/ Drosoph                                                               

F34D6.3 sup-9 P W All gene names: sup-9; twk-23; twk-38; F34D6.3; 2C976; CE28297; WBGene00006318; WP:CE28297 WormBase description: sup-9 encodes one of 44 C. elegans TWK (two-P domain K+) potassium channel subunits that contain two pore-forming domains and four transmembrane domains; sup-9 was originally defined by gain-of-function mutations that result in defects in pharyngeal, body-wall, egg-laying, and enteric muscle activation; loss of sup-9 function via reversion or RNA-mediated interference (RNAi) does not result in any abnormalities suggesting that SUP-9 may function redundantly with other TWK channels; SUP-9 is expressed in neurons and muscle.
                                              
Member of lists (Publications lists):
                                              McCarroll et al 2004  SFig1-4                                     
                                              conserved w/ Drosoph, ViswanathanM et al 2005  S2                                  
                                              daf-16 Resveratrol                                                                 

F35D2.5 syd-1 P W All gene names: syd-1; F35D2.5; F35D2.5c.1; F35D2.5c.2; 2H876; CE33069; CE33391; CE33392; NM_063191; WBGene00006363; WP:CE33069; WP:CE33391; WP:CE33392 WormBase description: transcriptional activator HAP4 and regulatory domain of BCR and P85A
                                              
Member of lists (Publications lists):
                                              McCarroll et al 2004  SFig1-4                                     
                                              conserved w/ Drosoph, ViswanathanM et al 2005  S2                                  
                                              sir-2.1 regulated, ViswanathanM et al 2005  S2 daf-16                              
                                              Resveratrol, Wang et al 2003  S5 genes common to                                   
                                              feeding ANOVA, Wang et al 2003  S3  genes pass one-way                             
                                              ANOVA                                                                              

F35H12.3 sel-12 P W All gene names: sel-12; sum-1; F35H12.3; CE24946; NM_075774; WBGene00004769; WP:CE24946; XB535 WormBase description: sel-12 encodes a transmembrane domain protein orthologous to presenilins; during gonadal, germline, and vulval development, sel-12 functions, within receiving cells, to positively regulate lin-12 and glp-1 Notch-like signaling pathways.
                                              
Member of lists (Publications lists):
                                              McCarroll et al 2004  SFig1-4                                     
                                              conserved w/ Drosoph                                                               

F41F3.2 soc-1 P W All gene names: soc-1; F41F3.2; 5F125; CE30786; NM_071849; WBGene00004928; WP:CE30786
                                              
Member of lists (Publications lists):
                                              Wang et al 2003  S3  genes pass                                   
                                              one-way ANOVA, Wang et al 2003  S4 Dauer Enriched, Wang                            
                                              et al 2003  S4 genes pass two-wayANOVA P0                                          

F42A9.2 lin-49 P W All gene names: lin-49; F42A9.2; 4J389; CE07224; NM_069074; WBGene00003034; WP:CE07224 WormBase description: zinc-finger protein
                                              
Member of lists (Publications lists):
                                              McCarroll et al 2004  SFig5 conserved                             
                                              w/ yeast, McCarroll et al 2004  SFig1-4 conserved w/                               
                                              Drosoph, Reinke et al 2004, list of genes in cluster F,                            
                                              Reinke et al 2004, list of genes in cluster order,                                 
                                              Reinke et al 2004, wt herm vs wt male enriched gen,                                
                                              ViswanathanM et al 2005  S2 sir-2.1 regulated                                      

F42G8.12 isp-1 P W All gene names: isp-1; F42G8.12; F42G8.12.1; F42G8.12.2; 4I900; CE17071; NM_068960; WBGene00002162; WP:CE17071 WormBase description: isp-1 encodes a Rieske iron sulphur protein (ISP) which is a subunit of the mitochondrial complex III in the mitochondrial membrane; the subunits are highly conserved in all mitochondria and aerobic bacteria; mitochondrial complex III catalyses electron transport from ubiquinol to cytochrome c; isp-1 mutants show low oxygen consumption, a decreased sensitivity to reactive oxygen species and increased lifespan suggesting that mitochondrial electron transport is a key factor affecting life span; isp-1 affects the rates of physiological processes like reproduction and development and also affects behavior. WormBase CDS description: ubiquinol-cytochrome C reductase
                                              
Member of lists (Publications lists):
                                              McCarroll et al 2004  SFig5 conserved                             
                                              w/ yeast, McCarroll et al 2004  SFig1-4 conserved w/                               
                                              Drosoph, ViswanathanM et al 2005  S2 sir-2.1 regulated,                            
                                              Wang et al 2003  S4 Climbing, Wang et al 2003  S3                                  
                                              genes pass one-way ANOVA, Wang et al 2003  S4 genes                                
                                              pass two-wayANOVA P0                                                               

F44G4.8 dep-1 P W All gene names: dep-1; F44G4.8; 2J296; CE03335; NM_063524; WBGene00009717; WP:CE03335 WormBase description: protein tyrosine phosphatase
                                              
Member of lists (Publications lists):
                                              Jones et al 2001  Dauer specific genes                            
                                              P<0.05, McCarroll et al 2004  SFig1-4 conserved w/                                 
                                              Drosoph, Wang et al 2003  S7 SAGE genes in the dataset,                            
                                              Wang et al 2003  S8 SAGE genes in the dauer exit                                   

F45B8.4 pag-3 P W All gene names: pag-3; F45B8.4; CE24977; NM_078079; WBGene00003909; WP:CE24977; XP570 WormBase description: The pag-3 gene encodes a homolog of the human gene ZNF195 (or p57KIP2), which when mutated leads to Beckwith-Wiedemann syndrome (OMIM:130650). WormBase CDS description: Zinc finger, C2H2 type (5 domains)
                                              
Member of lists (Publications lists):
                                              McCarroll et al 2004  SFig1-4                                     
                                              conserved w/ Drosoph, ViswanathanM et al 2005  S2                                  
                                              sir-2.1 regulated                                                                  

F46E10.9 dpy-11 P W All gene names: dpy-11; F46E10.9; F46E10.9.1; F46E10.9.2; F46E10.9.3; F46E10.E; 5G992; CE20819; NM_072254; WBGene00001073; WP:CE20819 WormBase description: dpy-11 encodes a membrane- associated thioredoxin- like (TRX) protein that affects body shape and ray morphology; the TRX domain displays catalytic activity in vitro, and dpy-11 is expressed in cytoplasm of hypodermis. WormBase CDS description: thioredoxin
                                              
Member of lists (Publications lists):
                                              Reinke et al 2004, fem1 enriched                                  
                                              genes, Reinke et al 2004, list of genes in cluster                                 
                                              order, Reinke et al 2004, mixed oogenesis soma, Reinke                             
                                              et al 2004, list of genes in cluster B, Wang et al 2003                            
                                               S4 Climbing, Wang et al 2003  S3  genes pass one-way                              
                                              ANOVA, Wang et al 2003  S4 genes pass two-wayANOVA P0                              

F47A4.2 dpy-22 P W All gene names: dpy-22; mdt-12; psa-6; sop-1; F47A4.2; CE16058; NM_077244; WBGene00001081; WP:CE16058; XK430 WormBase description: dpy-22 encodes a broadly expressed protein, homologous to the human transcriptional mediator protein TRAP230, which is involved in WNT and RAS signaling, as well as in dosage compensation; DPY-22 has a C-terminal glutamine-rich domain that is dispensable for inhibition of RAS-dependent cell differentiation, but is required for inhibition of BAR-1-dependent gene expression.
                                              
Member of lists (Publications lists):
                                              Reinke et al 2004, wt herm vs wt male                             
                                              enriched gen                                                                       

F47G6.1 dyb-1 P W All gene names: dyb-1; F47G6.1; 1B963; CE26812; NM_058459; WBGene00001115; WP:CE26812 WormBase description: The dyb-1 gene encodes a homolog of mammalian alpha-dystrobrevin (DTNA; OMIM:601239), mutation of which can lead to left ventricular noncompaction with congenital heart defects.
                                              
Member of lists (Publications lists):
                                              McCarroll et al 2004  SFig1-4                                     
                                              conserved w/ Drosoph                                                               

F48E8.1 lon-1 P W All gene names: lon-1; F48E8.1; 3G567; CE01953; CE29046; CE30996; NM_065765; NM_065766; NM_171866; WBGene00003055; WP:CE01953; WP:CE29046; WP:CE30996 WormBase description: The lon-1 gene encodes a protein belonging to the PR-protein superfamily that is a target of DBL-1 (TGF-beta) signaling, and that regulates polyploidization and body length.
                                              
Member of lists (Publications lists):
                                              ViswanathanM et al 2005  S2 sir-2.1                               
                                              regulated, Wang et al 2003  S4 Early genes, Wang et al                             
                                              2003  S3  genes pass one-way ANOVA, Wang et al 2003  S4                            
                                              genes pass two-wayANOVA P0                                                         

F49E11.1 mbk-2 P W All gene names: mbk-2; F49E11.1; F49E11.1d.1; F49E11.1d.2; F49E11.1d.3; 4N799; CE05897; CE19878; CE23751; CE39735; CE39938; NM_070091; WBGene00003150; WP:CE05897; WP:CE19878; WP:CE23751; WP:CE39735; WP:CE39938 WormBase description: mbk-2 encodes one of two C. elegans members of the DYRK (dual-specificity Yak1-related kinase) family of proteins that includes S. cerevisiae Yak1 and the Drosophila minibrain and DYRK2 kinases; MBK-2 activity is required maternally for the egg-to-embryo transition that occurs during the earliest stages of embryonic development; specifically, MBK-2 is required for: 1) posterior localization of the germ plasm components PIE-1, POS-1, and PGL-1, and 2) postfertilization degradation of a subset of maternal proteins including the MEI-1 and MEI-2 meiosis-specific katanin subunits, the OMA-1 oocyte maturation factor, and residual PIE-1 that remains anteriorly localized after its normal posterior segregation; genetic analyses suggest that, in regulating the segregation and degradation of maternal proteins, mbk-2 lies downstream of the initial embryonic polarity cues established by the PAR/MEX proteins; MBK-2, whose activity appears to depend upon progression through the meiotic divisions, is expressed uniformly in the cortex of oocytes and newly fertilized zygotes; in later zygotes, just prior to the second meiotic division, MBK-2 becomes localized to discrete cortical foci, and by the first mitosis it is found predominantly on centrosomes and chromosomes; MBK-2 is also associated with P granules in the germline blastomeres P2, P3, and P4.
                                              
Member of lists (Publications lists):
                                              Reinke et al 2004, fem1 enriched                                  
                                              genes, Reinke et al 2004, wt vs glp-4 enriched genes,                              
                                              Reinke et al 2004, oogenesis enriched genes                                        

F52A8.2 gpb-2 P W All gene names: eat-11; gpb-2; F52A8.2; 1H896; CE17845; NM_059671; WBGene00001680; WP:CE17845 WormBase description: gpb-2 encodes an ortholog of Gbeta(5), that is dispensable for viability, but required for normal egg-laying, locomotion, and pharyngeal pumping; GBP-2 may regulate the interaction between the GOA-1 and EGL-30 signaling pathways based on genetic analysis; gpb-2 is expressed throughout development in the nervous system and in muscle, and expression is dependent upon expression of both EAT-16 and EGL-10. WormBase CDS description: guanine nucleotide-binding protein
                                              
Member of lists (Publications lists):
                                              McCarroll et al 2004  SFig1-4                                     
                                              conserved w/ Drosoph, Murphy et al 2003  Fig2 Class1                               
                                              elongate lifespan                                                                  

F52B10.1 nmy-1 P W All gene names: nmy-1; F52B10.1; CE31177; NM_076103; WBGene00003776; WP:CE31177; XD535 WormBase description: nmy-1 encodes a class II non-muscle myosin heavy chain related to Drosophila zipper, which plays a role in several aspects of embryonic morphogenesis; in C. elegans, NMY-1 is required for embryonic elongation and establishment of normal body morphology; mutations in nmy-1 suppress the hypercontraction phenotype produced by mutations in mel-11, a myosin phosphatase that regulates actomyosin filament contraction; in addition, NMY-1 may partner with MLC-4, myosin light chain 4, during elongation; NMY-1 expression is detected during embryogenesis, particularly at the onset of elongation. WormBase CDS description: myosin
                                              
Member of lists (Publications lists):
                                              McCarroll et al 2004  SFig5 conserved                             
                                              w/ yeast, McCarroll et al 2004  SFig1-4 conserved w/                               
                                              Drosoph, Reinke et al 2004, list of genes in cluster                               
                                              order, Reinke et al 2004, list of genes in cluster C,                              
                                              ViswanathanM et al 2005  S2 daf-16 Resveratrol                                     

F52C9.8 pqe-1 P W All gene names: pqe-1; F52C9.8; F52C9.8d.1; F52C9.8d.2; 3G411; CE30672; CE30673; CE30674; CE30675; CE30802; CE30998; CE39256; NM_065734; NM_065735; NM_065736; NM_171119; NM_171120; NM_171864; WBGene00004095; WP:CE30672; WP:CE30673; WP:CE30674; WP:CE30675; WP:CE30802; WP:CE30998; WP:CE39256
                                              
Member of lists (Publications lists):
                                              Reinke et al 2004, intrinsic, Reinke                              
                                              et al 2004, wt vs glp-4 enriched genes                                             

F52H3.1 let-268 P W All gene names: let-268; F52H3.1; F52H3.1.1; F52H3.1.2; F52H3.1.3; 2K324; CE03397; NM_063769; WBGene00002497; WP:CE03397 WormBase description: let-268 encodes a procollagen lysyl hydroxylase that processes type IV collagen, a collagen secreted and incorporated into the basement membrane during embryogenesis (and encoded partly by emb-9); LET-268 activity is essential for type IV collagen processing and secretion and for the stability, but not the formation of, the basement membrane that provides mechanical support to body wall muscle once contraction begins; LET-268 also appears to be required for pharyngeal muscle contraction. WormBase CDS description: procollagen-lysine,2-oxoglutarate 5-dioxygenase precusor
                                              
Member of lists (Publications lists):
                                              McCarroll et al 2004  SFig1-4                                     
                                              conserved w/ Drosoph, Reinke et al 2004, list of genes                             
                                              in cluster order, Reinke et al 2004, list of genes in                              
                                              cluster B, Wang et al 2003  S4 Early genes, Wang et al                             
                                              2003  S3  genes pass one-way ANOVA, Wang et al 2003  S4                            
                                              genes pass two-wayANOVA P0                                                         

F53A2.8 mtm-6 P W All gene names: cup-6; mtm-6; F53A2.8; F53A2.8b.1; F53A2.8b.2; 3O443; CE16100; CE32050; CE37116; NM_067352; NM_181951; WBGene00003478; WP:CE16100; WP:CE32050; WP:CE37116 WormBase description: mtm-6 encodes a myotubularin-related protein that regulates phosphoinositide 3-phosphate localization and/or levels in vivo and mutation blocks endocytosis by coelomocytes; the MTM-6A isoform, which rescues the endocytic defect of mtm-6 mutants, is believed to function as part of a complex with MTM-9 and MTM-6A is predominantly localized to the coelomocyte cytoplasm, with some localization to the coelomocyte membrane.
                                              
Member of lists (Publications lists):
                                              McCarroll et al 2004  SFig5 conserved                             
                                              w/ yeast, McCarroll et al 2004  SFig1-4 conserved w/                               
                                              Drosoph, Reinke et al 2004, list of genes in cluster F,                            
                                              Reinke et al 2004, fem1 enriched genes, Reinke et al                               
                                              2004, list of genes in cluster order, Reinke et al                                 
                                              2004, oogenesis enriched genes, Reinke et al 2004, wt                              
                                              vs glp-4 enriched genes, Reinke et al 2004, wt herm vs                             
                                              wt male enriched gen, Reinke et al 2004, GO categories,                            
                                              ViswanathanM et al 2005  S2 daf-16 Resveratrol,                                    
                                              ViswanathanM et al 2005  S2 sir-2.1 regulated                                      

F54C1.3 mes-3 P W All gene names: mes-3; F54C1.3; 1F571; CE11046; CE36305; NM_059094; WBGene00003221; WP:CE11046; WP:CE36305 WormBase description: mes-3 encodes a novel protein with no discernible motifs; however, as a member of a Polycomb-like chromatin repressive complex with MES-2 and MES-6, MES-3 is required maternally for normal germline development and during larval development, for anteroposterior patterning; during germline development, the MES-2/MES-3/MES-6 complex is believed to be essential for maintaining repression of the X chromosome, and in transgenic animals, the complex is necessary for germline repression of repetitive transgenes; in axial patterning, the MES-2/MES-3/MES-6 complex is required in somatic tissues for maintaining homeotic gene repression, acting upstream of the Hox genes lin-39, mab-5, and egl-5, as well as the egl-5 target gene lin-32; MES-3 expression is detected in the nuclei of all cells during early embryogenesis, in some somatic cells and the germline precursors Z2 and Z3 during late embryogenesis and the L1 larval stage; in adults, MES-3 is expressed at highest levels in oocytes and germline nuclei in the proximal meiotic region with expression in the pachytene region negatively regulated by the RNA-binding protein GLD-1; MES-3 appears to be localized primarily to the nucleoplasm with some chromosomal association detectable during metaphase and early anaphase; in >24-cell-stage embryos, normal MES-3 levels and localization are dependent upon wild-type activity of MES-2 and MES-6
                                              
Member of lists (Publications lists):
                                              Reinke et al 2004, fem1 enriched                                  
                                              genes, Reinke et al 2004, list of genes in cluster                                 
                                              order, Reinke et al 2004, mixed oogenesis soma, Reinke                             
                                              et al 2004, list of genes in cluster E, ViswanathanM et                            
                                              al 2005  S2 daf-16 Resveratrol                                                     

F54D8.1 dpy-17 P W All gene names: dpy-17; F54D8.1; F54D8.1.1; F54D8.1.2; 3G197; CE11066; NM_065685; WBGene00001076; WBGene00018799; WP:CE11066 WormBase description: Uncloned locus that affects body length and outgrowth of posterior canal cell processes.
                                              
Member of lists (Publications lists):
                                              Reinke et al 2004, list of genes in                               
                                              cluster A, Reinke et al 2004, list of genes in cluster                             
                                              order, Reinke et al 2004, wt herm vs wt herm enriched                              
                                              gen, Reinke et al 2004, IVb male soma enriched genes,                              
                                              ViswanathanM et al 2005  S2 sir-2.1 regulated,                                     
                                              ViswanathanM et al 2005  S2 daf-16 Resveratrol                                     

F54F7.5 mes-1 P W All gene names: mes-1; F54F7.5; CE28237; NM_171780; WBGene00003219; WP:CE28237; XM479 WormBase description: The mes-1 gene encodes a receptor tyrosine kinase-like protein that is required for unequal cell divisions in the early embryonic germline; during embryonic cell divisions, mes-1 is involved in positioning of the early mitotic spindle and of associated P granules. WormBase CDS description: tyrosine-protein kinase
                                              
Member of lists (Publications lists):
                                              Reinke et al 2004, list of genes in                               
                                              cluster order, Reinke et al 2004, list of genes in                                 
                                              cluster E, ViswanathanM et al 2005  S2 sir-2.1                                     
                                              regulated                                                                          

F55A8.1 egl-18 P W All gene names: egl-18; elt-5; pvl-3; F55A8.1; F55A8.1.1; F55A8.1.2; F55A8.1.3; 4C681; CE28339; NM_067742; WBGene00001186; WP:CE28339 WormBase description: egl-18 encodes a member of the GATA-family of transcription factors that affects cell migration, cell fate specification; expressed in the head, in hypodermal seam cells, VC neurons, and vulval precursor cells. WormBase CDS description: zinc finger protein
                                              
Member of lists (Publications lists):
                                              Reinke et al 2004, fem1 enriched                                  
                                              genes, Reinke et al 2004, list of genes in cluster                                 
                                              order, Reinke et al 2004, mixed oogenesis soma, Reinke                             
                                              et al 2004, list of genes in cluster E, ViswanathanM et                            
                                              al 2005  S2 sir-2.1 regulated                                                      

F55A8.2 egl-4 P W All gene names: cgk-1; egl-4; odr-9; F55A8.2; F55A8.2a.1; F55A8.2a.2; 4C643; CE19897; CE19898; CE31541; CE37241; CE37242; CE37718; NM_067740; NM_067741; NM_171279; NM_171280; WBGene00001173; WP:CE19897; WP:CE19898; WP:CE31541; WP:CE37241; WP:CE37242; WP:CE37718 WormBase description: The egl-4 gene encodes a cyclic GMP-dependant protein kinase that may act through the TGF-beta signalling pathway relay sensory cues that modulate chemosensory behavior, dauer formation, foraging and egg-laying.
                                              
Member of lists (Publications lists):
                                              Roy et al 2002  S3 muscle genes,                                  
                                              ViswanathanM et al 2005  S2 sir-2.1 regulated                                      

F56A3.4 spd-5 P W All gene names: spd-5; F56A3.4; 1F740; CE28834; NM_059138; WBGene00004955; WP:CE28834
                                              
Member of lists (Publications lists):
                                              Reinke et al 2004, intrinsic, Reinke                              
                                              et al 2004, list of genes in cluster F, Reinke et al                               
                                              2004, wt vs glp-4 enriched genes, Reinke et al 2004,                               
                                              list of genes in cluster order, ViswanathanM et al 2005                            
                                               S2 daf-16 Resveratrol                                                             

F56H11.4 elo-1 P W All gene names: elo-1; pea-1; F56H11.4; 4K291; CE05979; CEEL01; NM_069288; WBGene00001239; WP:CE05979; ceelo1 WormBase description: elo-1 encodes a component of C-18 polyunsaturated fatty acid (PUFA) elongase that is required for normal elongation of n-6 and n-3 20-carbon PUFA in vivo; ELO-1 is a condensing enzyme that elongates n-6 and n-7 (and, with less efficiency, n-3) series C18 PUFAs. WormBase CDS description: Yeast YJT6 like
                                              
Member of lists (Publications lists):
                                              McCarroll et al 2004  SFig5 conserved                             
                                              w/ yeast, ViswanathanM et al 2005  S2 sir-2.1                                      
                                              regulated, Wang et al 2003  S4 Early genes, Wang et al                             
                                              2003  S3  genes pass one-way ANOVA, Wang et al 2003  S4                            
                                              genes pass two-wayANOVA P0                                                         

F58A3.2 egl-15 P W All gene names: egl-15; F58A3.2; F58A3.2b.1; F58A3.2b.2; F58A3.2b.3; CE28238; CE29049; CE31549; CE35726; CE35727; NM_077441; WBGene00001184; WP:CE28238; WP:CE29049; WP:CE31549; WP:CE35726; WP:CE35727; XL641 WormBase description: egl-15 encodes an FGF-like receptor tyrosine kinase orthologous to human FGFR1 (OMIM:136350, which when mutated leads to Pfeiffer syndrome); EGL-15 is required for several processes including fluid balance and sex myoblast migration, which is essential for proper development of the egg-laying system, and is required to phosphorylate SAX-7, which inhibits the colocalization of SAX-7 with the ankyrin UNC-44; EGL-15 activators may include the FGF-like signalling molecules EGL-17 and LET-756; negative regulators include CLR-1, a receptor protein-tyrosine phosphatase.
                                              
Member of lists (Publications lists):
                                              McCarroll et al 2004  SFig1-4                                     
                                              conserved w/ Drosoph, ViswanathanM et al 2005  S2                                  
                                              sir-2.1 regulated, ViswanathanM et al 2005  S2 daf-16                              
                                              Resveratrol                                                                        

F58A4.8 tbg-1 P W All gene names: sas-3; tbg-1; F58A4.8; F58A4.8.1; F58A4.8.2; 3K716; CE00224; NM_066730; TUBG; WBGene00006540; WP:CE00224 WormBase description: tbg-1 encodes gamma-tubulin; in C. elegans, tbg-1 activity is essential and is required for normal bipolar spindle assembly and function, as well as the fast phase of female pronuclear migration following fertilization; while tbg-1 is required for proper organization and function of kinetochore and interpolar microtubules, it does not appear to be absolutely required for microtubule nucleation and growth; TBG-1 localizes to centrosomes in both interphase and mitotic cells, exhibiting a dynamic behavior during mitosis that differs between anterior and posterior centrosomes. WormBase CDS description: Gamma-like tubulin
                                              
Member of lists (Publications lists):
                                              McCarroll et al 2004  SFig5 conserved                             
                                              w/ yeast, McCarroll et al 2004  SFig1-4 conserved w/                               
                                              Drosoph, Reinke et al 2004, list of genes in cluster                               
                                              order, Reinke et al 2004, intrinsic, Reinke et al 2004,                            
                                              wt vs glp-4 enriched genes, Reinke et al 2004, wt herm                             
                                              vs wt male enriched gen, Reinke et al 2004, list of                                
                                              genes in cluster E, ViswanathanM et al 2005  S2 sir-2.1                            
                                              regulated                                                                          

F58D5.4 ksr-2 P W All gene names: ksr-2; pex-1; F58D5.4; 1M640; CE31017; CE31018; WBGene00002240; WP:CE31017; WP:CE31018
F58H12.1 kin-29 P W All gene names: kin-29; sma-11; sns-8; F58H12.1; CE28479; NM_076092; WBGene00002210; WP:CE28479; XD464 WormBase description: kin-29 encodes a serine/threonine kinase with significant homology in the kinase domain to the AMP-activated protein kinase (AMPK) and SNF1 kinases; the AMP-kinase cascade is activated by cellular stresses that deplete ATP; AMP-kinase is believed to protect the mammalian cell by 'switching off' ATP-consuming pathways like fatty acid synthesis, by phosphorylating key regulatory enzymes, and switching on alternative pathways for ATP generation; kin-29 is involved in regulating the expression of chemosensory receptors and entry into the daur pathway; kin-29 also affects body size via interaction with the Sma/Mab pathway and lifespan, with mutants exhibiting a smaller body size and increased life span; a functional KIN-29-GFP fusion protein is expressed in sensory neurons and many other cell types, and localizes to the cytoplasm; under conditions of cellular stress like heat shock and starvation, KIN-29-GFP translocates to the nucleus. WormBase CDS description: serine/threonine-protein kinase
                                              
Member of lists (Publications lists):
                                              Reinke et al 2004, list of genes in                               
                                              cluster order, Reinke et al 2004, list of genes in                                 
                                              cluster B                                                                          

F59A6.1 nsy-1 P W All gene names: ask-1; esp-8; nsy-1; F59A6.1; 2F319; CE33405; NM_062524; WBGene00003822; WP:CE33405 WormBase description: nsy-1 encodes a MAP kinase kinase kinase homolog that affects chemotaxis, egg laying, and pathogen response; NSY-1 activity is activated by the calmodulin kinase UNC-43, and is required for lateral signalling that leads to asymmetric olfactory neuron fates; interacts with SEK-1, and is expressed in the intestine, hypodermis, rectal gland cells, and neurons. WormBase CDS description: Protein kinase
                                              
Member of lists (Publications lists):
                                              McCarroll et al 2004  SFig5 conserved                             
                                              w/ yeast, McCarroll et al 2004  SFig1-4 conserved w/                               
                                              Drosoph                                                                            

F59E12.2 zyg-1 P W All gene names: zyg-1; F59E12.2; F59E12.2.1; F59E12.2.2; 2F943; CE28571; NM_062702; WBGene00006988; WP:CE28571 WormBase description: zyg-1 encodes a homolog of polo-like and calcium-dependent kinases that is required for daughter centriole formation; ZYG-1 localizes transiently to centrosomes and acts at least one cell cycle prior to each spindle assembly event; ZYG-1 activity is required for proper localization of the SAS-5 and SAS-6 coiled-coil proteins that are also required for centriole duplication.
                                              
Member of lists (Publications lists):
                                              Reinke et al 2004, list of genes in                               
                                              cluster F, Reinke et al 2004, list of genes in cluster                             
                                              order, ViswanathanM et al 2005  S2 sir-2.1 regulated                               

H26D21.1 hus-1 P W All gene names: dam-1; hus-1; H26D21.1; H26D21.B; 1E267; CE20999; NM_058802; WBGene00002042; WP:CE20999 WormBase description: hus-1 encodes the C. elegans ortholog of the Schizosaccharomyces pombe Hus1 DNA damage checkpoint protein; in C. elegans, hus-1 activity is required for DNA damage-induced cell cycle arrest and apoptosis, telomere maintenance, and hence, genome stability and development; specifically, hus-1 is required for the CEP-1/p53-dependent increase in germline egl-1 expression following irradiation; a HUS-1::GFP fusion protein is detected in the nuclei of mitotic and meiotic germ cells, mature oocytes, embryos, and somatic larval cells, particularly those that are proliferating; while HUS-1 localization is generally diffuse throughout these nuclei, following irradiation, HUS-1 localizes to discrete foci that overlap with chromatin; HUS-1 nuclear localization is dependent upon the Rad9 homologue HPR-9 and upon the checkpoint protein MRT-2, with which it interacts in yeast two-hybrid and in vitro assays.
                                              
Member of lists (Publications lists):
                                              Reinke et al 2004, intrinsic, Reinke                              
                                              et al 2004, wt vs glp-4 enriched genes, Reinke et al                               
                                              2004, list of genes in cluster order, Reinke et al                                 
                                              2004, wt herm vs wt male enriched gen, Reinke et al                                
                                              2004, list of genes in cluster E, ViswanathanM et al                               
                                              2005  S2 sir-2.1 regulated                                                         

H35N03.1 exp-1 P W All gene names: exp-1; H35N03.1; 2G446; CE37026; NM_062828; WBGene00001373; WP:CE37026 WormBase description: ion channel
                                              
Member of lists (Publications lists):
                                              ViswanathanM et al 2005  S2 sir-2.1                               
                                              regulated                                                                          

H38K22.1 evl-14 P W All gene names: evl-14; H38K22.1; 3F394; CE33526; NM_065464; WBGene00001352; WP:CE33526 WormBase description: evl-14 encodes a homolog of the yeast sister cohesion protein Pds5p that functions during both mitosis and meiosis and is implicated in the maintenance of sister chromatid cohesion in late prophase, and affects vulval morphology, meiotic germline development, embryonic and larval viability, fertility, and cell divisions in the germ line as well as in vulval and somatic gonad lineages; some of the defects, such as somatic gonad defects, are due at least partially to cell division defects.
                                              
Member of lists (Publications lists):
                                              McCarroll et al 2004  SFig1-4                                     
                                              conserved w/ Drosoph, Reinke et al 2004, intrinsic,                                
                                              Reinke et al 2004, wt vs glp-4 enriched genes, Reinke                              
                                              et al 2004, list of genes in cluster order, Reinke et                              
                                              al 2004, wt herm vs wt male enriched gen, Reinke et al                             
                                              2004, list of genes in cluster E, ViswanathanM et al                               
                                              2005  S2 sir-2.1 regulated                                                         

JC8.10 unc-26 P W All gene names: unc-26; unc-48; JC8.10; 4O26; CE28239; CE29050; WBGene00006763; WP:CE28239; WP:CE29050 WormBase description: unc-26 encodes synaptojanin, a polyphosphoinositide phosphatase orthologous to human synaptojanin 1 (OMIM:604297, 309000, which when mutated leads to Lowe oculocerebrorenal syndrome); UNC-26 is required for normal locomotion, pharyngeal pumping, and defecation, and specifically, appears to function in multiple steps of synaptic vesicle recycling; UNC-26 may also play a role in cytoskeletal organization.
                                              
Member of lists (Publications lists):
                                              Reinke et al 2004, fem1 enriched                                  
                                              genes, Reinke et al 2004, wt herm vs wt male enriched                              
                                              gen, Reinke et al 2004, mixed oogenesis soma                                       

K02E10.2 hid-1 P W All gene names: hid-1; K02E10.2; CE04694; CE34327; NM_076053; WBGene00001844; WP:CE04694; WP:CE34327; XD111
                                              
Member of lists (Publications lists):
                                              McCarroll et al 2004  SFig1-4                                     
                                              conserved w/ Drosoph                                                               

K03B8.9 deg-3 P W All gene names: deg-3; K03B8.9; K03B8.9.1; K03B8.9.2; 5L894; CE06083; NM_073496; WBGene00000951; WP:CE06083 WormBase description: deg-3 encodes an alpha subunit of a nicotinic acetylcholine receptor (nAChR); originally defined by a gain-of-function mutation that results in neuronal degeneration and uncoordinated movement, DEG-3 can form heteromeric channels with a second alpha subunit, DES-2, and in vivo these channels appear to be required for chemosensation of choline; deg-3 and des-2 reside in an operon, and consistent with their role in metabolite chemosensation, are expressed in nonsynaptic regions such as the sensory endings of the IL2 chemosensory neurons; DEG-3 and DES-2 are also detected in the touch cell neurons, M1 head muscles, FLP and PVD sensory neurons, and the PVC interneuron; in subsets of these neurons, DEG-3 expression is not detectable in mec-3 or unc-86 mutant backgrounds. WormBase CDS description: nicotinic acetylcholine receptor
                                              
Member of lists (Publications lists):
                                              Reinke et al 2004, list of genes in                               
                                              cluster A, Reinke et al 2004, list of genes in cluster                             
                                              order, ViswanathanM et al 2005  S2 daf-16 Resveratrol                              

K04D7.5 gon-4 P W All gene names: gon-4; K04D7.5; 4K967; CE35579; NM_069463; WBGene00001653; WP:CE35579 WormBase description: gon-4 encodes a large (1336-residue), unfamiliar, acidic (20% acidic residues and pI of 4.4), nuclear protein directly required for gonadogenesis in both sexes and, indirectly, for proper germ line and vulval development; gon-4 is expressed (and functionally required) in somatic gonadal cells during early gonadal development; while Z1 and Z4 (the somatic gonad precursor cells) appear to be specified correctly in gon-4 mutant L1 larvae, and other postembryonic events in somatic gonadal development appear to still occur at normal times, the postembryonic cell divisions of Z1 and Z4 are greatly delayed or missing in gon-4 larvae; GON-4 is subtly similar to human HCCA2 (OMIM:607860, expression associated with hepatocellular carcinoma).
                                              
Member of lists (Publications lists):
                                              Reinke et al 2004, fem1 enriched                                  
                                              genes, Reinke et al 2004, wt vs glp-4 enriched genes,                              
                                              Reinke et al 2004, list of genes in cluster order,                                 
                                              Reinke et al 2004, oogenesis enriched genes, Reinke et                             
                                              al 2004, wt herm vs wt male enriched gen, Reinke et al                             
                                              2004, list of genes in cluster E, ViswanathanM et al                               
                                              2005  S2 sir-2.1 regulated                                                         

K04G11.2 sel-7 P W All gene names: sel-7; K04G11.2; CE35893; NM_077991; WBGene00004764; WP:CE35893; XO950 WormBase description: sel-7 encodes a novel protein with two predicted PEST sequences that is conserved in the related nematode C. briggsae and several parasitic nematodes, but has no known homologs in other organisms; sel-7 was identified in screens for suppressors of dominant lin-12 mutations that result in vulvaless and egg-laying defective animals; although loss of SEL-7 function via mutation or RNAi results in no obvious defects in a wild-type background, genetic studies suggests that SEL-7 acts downstream of LIN-12/Notch to positively regulate LIN-12 signaling, perhaps by regulating the activity or formation of the LAG-1, LIN-12(intra), SEL-8 nuclear complex; in vitro, SEL-7 self-associates and also interacts with TIR-1 (F13B10.1B), a protein that contains sterile alpha and Toll interleukin receptor motifs, and MDT-29 (K08E3.8), a glutamine-rich protein similar to mediator complex subunits, however the functional significance of these interactions is not yet known; a SEL-7::GFP translational fusion reveals expression in the nuclei of several cell types, including vulval precursor cells and those of the developing gonad.
                                              
Member of lists (Publications lists):
                                              Romagnolo et al 2002  Fig3b Unkown,                               
                                              ViswanathanM et al 2005  S2 sir-2.1 regulated,                                     
                                              ViswanathanM et al 2005  S2 daf-16 Resveratrol                                     

K06A5.7 cdc-25.1 P W All gene names: cdc-25.1; lin-60; CDC25.1; K06A5.7; K06A5.7.1; K06A5.7.2; 1H46; CE11778; NM_059461; WBGene00000386; WP:CE11778 WormBase description: cdc-25.1 encodes a CDC25 phosphatase homolog that affects embryonic viability, meiosis, mitosis, proliferation of the intestine (E cell lineage), and germ line proliferation; it is expressed in the developing germline, in the nuclei of oocytes, embryonic nuclei, nuclei of embryonic cortical membranes, and sperm pronuclei, and in the germline precursors Z2 and Z3. WormBase CDS description: protein phosphatase
                                              
Member of lists (Publications lists):
                                              Reinke et al 2004, fem1 enriched                                  
                                              genes, Reinke et al 2004, Fig2b shared gemlines, Reinke                            
                                              et al 2004, list of genes in cluster order, Reinke et                              
                                              al 2004, oogenesis enriched genes, Reinke et al 2004,                              
                                              wt vs glp-4 enriched genes, Reinke et al 2004, wt males                            
                                              vs glp4 male enriched , Reinke et al 2004, wt herm vs                              
                                              wt male enriched gen, Reinke et al 2004, list of genes                             
                                              in cluster E, ViswanathanM et al 2005  S2 sir-2.1                                  
                                              regulated                                                                          

K07C11.2 air-1 P W All gene names: air-1; let-412; K07C11.2; K07C11.2.1; K07C11.2.2; 5I703; CE21025; NM_072718; WBGene00000098; WP:CE21025 WormBase description: AIR-1 belongs to the Aurora-A family of serine/threonine kinases that localize to centrosomes; AIR-1 is required for embryonic survival, germline proliferation and development, locomotion, and vulval development; AIR-1 is required to recruit centrosomal gamma-tubulin during maturation; Aurora-A kinases are implicated in centrosome separation and spindle assembly. WormBase CDS description: protein kinase
                                              
Member of lists (Publications lists):
                                              McCarroll et al 2004  SFig1-4                                     
                                              conserved w/ Drosoph, Reinke et al 2004, intrinsic,                                
                                              Reinke et al 2004, Fig2b shared gemlines, Reinke et al                             
                                              2004, wt vs glp-4 enriched genes, Reinke et al 2004,                               
                                              list of genes in cluster order, Reinke et al 2004, wt                              
                                              males vs glp4 male enriched , Reinke et al 2004, list                              
                                              of genes in cluster E                                                              

K08C7.3 epi-1 P W All gene names: egf-3; epi-1; lgx-3; K08C7.3; 4L443; CE06136; CE25049; NM_069569; WBGene00001328; WP:CE06136; WP:CE25049 WormBase description: epi-1 encodes a laminin alpha chain that affects oogenesis due to its affect on gonad development, and also affects cell migrations, axon extension and GABAergic defasciculation, morphology of the VD and DD motor neurons, body morphology, locomotion, gonad sheath epithelialization, body muscle structure, and germ cell proliferation. WormBase CDS description: laminin
                                              
Member of lists (Publications lists):
                                              McCarroll et al 2004  SFig1-4                                     
                                              conserved w/ Drosoph, Reinke et al 2004, list of genes                             
                                              in cluster order, Reinke et al 2004, list of genes in                              
                                              cluster C, Wang et al 2003  S4 Early genes, Wang et al                             
                                              2003  S3  genes pass one-way ANOVA, Wang et al 2003  S4                            
                                              genes pass two-wayANOVA P0                                                         

K08E3.6 cyk-4 P W All gene names: cyk-4; K08E3.6; 3O858; CE18872; NM_067444; WBGene00000875; WP:CE18872 WormBase description: cyk-4 encodes a GTPase activating protein (GAP) for the Rho family of GTPases that, together with ZEN-4, is sufficient to promote the formation of the large bundles of microtubules that form the central spindle during anaphase, and is required for fertility and coordinated locomotion postembryonically; localizes to the central spindle during anaphase interdependently with ZEN-4, and interacts with ZEN-4 in vitro and in vivo. WormBase CDS description: Phorbol esters/diacylglycerol binding domain (C1 domain), GTPase-activator protein for Rho-like GTPases
                                              
Member of lists (Publications lists):
                                              McCarroll et al 2004  SFig1-4                                     
                                              conserved w/ Drosoph, Reinke et al 2004, intrinsic,                                
                                              Reinke et al 2004, wt vs glp-4 enriched genes,                                     
                                              ViswanathanM et al 2005  S2 sir-2.1 regulated                                      

K08E7.3 let-99 P W All gene names: let-99; K08E7.3; 4N335; CE06147; NM_070006; WBGene00002368; WP:CE06147 WormBase description: let-99 encodes a protein with a DEP domain (Domain found in Dishevelled, Egl-10, and Pleckstrin); LET-99 has no obvious homologs in non-nematodes, but has a truncated paralog (LRG-1) in C. elegans; LET-99 is required for the mitotic spindle to be properly oriented with respect to the axis of cellular polarity, both during anterior migration and rotation of the nuclear-centrosome complex and during anaphase; let-99 mutants exhibit hyperactive nuclear movement and abnormal anaphase spindle pole behavior; LET-99 is mislocalized in par-2 and par-3 mutants; like other proteins containing DEP domains, LET-99 may act as part of a G protein signalling pathway (e.g., the one controlling spindle position). WormBase CDS description: Domain found in Dishevelled, Egl-10, and Pleckstrin
                                              
Member of lists (Publications lists):
                                              Reinke et al 2004, fem1 enriched                                  
                                              genes, Reinke et al 2004, wt vs glp-4 enriched genes,                              
                                              Reinke et al 2004, list of genes in cluster order,                                 
                                              Reinke et al 2004, oogenesis enriched genes, Reinke et                             
                                              al 2004, wt herm vs wt male enriched gen, Reinke et al                             
                                              2004, list of genes in cluster E, ViswanathanM et al                               
                                              2005  S2 sir-2.1 regulated                                                         

K10B2.1 lin-23 P W All gene names: lin-23; stu-1; K10B2.1; K10B2.1.1; K10B2.1.2; 2G663; CE28600; NM_062884; WBGene00003009; WP:CE28600 WormBase description: lin-23 encodes an F-box- and WD-repeat-containing protein that is orthologous to Saccharomyces cerevisiae MET30 and human beta TRCP (OMIM:603482), both components of the SCF (Skp1, Cullin, F-box) ubiquitin-ligase complex that regulates ubiquitin-mediated protein degradation; LIN-23 negatively regulates postembryonic cell divsions in all tissue types, and specifically, has been shown to function cell autonomously in the vulva to negatively regulate cell cycle progression and allow for cell cycle exit; LIN-23 is most highly expressed in the early embryo and adult germline. WormBase CDS description: Transducin beta chain
                                              
Member of lists (Publications lists):
                                              McCarroll et al 2004  SFig1-4                                     
                                              conserved w/ Drosoph, Reinke et al 2004, intrinsic,                                
                                              Reinke et al 2004, wt vs glp-4 enriched genes, Reinke                              
                                              et al 2004, list of genes in cluster order, Reinke et                              
                                              al 2004, list of genes in cluster E, ViswanathanM et al                            
                                              2005  S2 sir-2.1 regulated                                                         

K10G6.1 lin-31 P W All gene names: lin-31; K10G6.1; 2E275; CE12098; NM_062303; WBGene00003017; WP:CE12098 WormBase description: lin-31 encodes a winged helix (WH)-like transcription factor that is a member of the HNF3/Forkhead family of DNA-binding proteins; LIN-31 acts as a tissue-specific effector of MAP kinase-mediated signaling in the vulva; when MAP kinase is inactive, LIN-31 forms a complex with LIN-1/Ets that inhibits vulval cell fates; upon MAP kinase activation (vulval induction), LIN-31 becomes phosphorylated, dissociates from LIN-1, and goes on to promote primary and secondary vulval cell fates; LIN-31 is expressed in the vulval precursor cells.
                                              
Member of lists (Publications lists):
                                              McCarroll et al 2004  SFig1-4                                     
                                              conserved w/ Drosoph                                                               

K11E8.1 unc-43 P W All gene names: dec-8; unc-43; K11E8.1; K11E8.1a.1; K11E8.1a.2; K11E8.1b.1; K11E8.1b.2; K11E8.1b.3; K11E8.1c.1; K11E8.1c.2; K11E8.1d.1; K11E8.1d.2; K11E8.1e.1; K11E8.1e.2; K11E8.1f.1; K11E8.1f.2; K11E8.1g.1; K11E8.1g.2; K11E8.1h.1; K11E8.1h.2; K11E8.1i.1; K11E8.1i.2; K11E8.1k.1; K11E8.1k.2; K11E8.1l.1; K11E8.1l.2; 4L90; CE28051; CE28052; CE28053; CE28054; CE28055; CE28056; CE28057; CE28058; CE28059; CE28060; CE28061; CE35590; WBGene00006779; WP:CE28051; WP:CE28052; WP:CE28053; WP:CE28054; WP:CE28055; WP:CE28056; WP:CE28057; WP:CE28058; WP:CE28059; WP:CE28060; WP:CE28061; WP:CE35590 WormBase description: unc-43(gf) mutants (in which unc-43 is overexpressed) suppress the excess motoneuron branching, and thus the uncoordinated phenotype, induced by an unc-6deltaC transgene. WormBase CDS description: Ca2+/calmodulin-dependent protein kinase
K11G9.4 egl-46 P W All gene names: egl-46; K11G9.4; 5H160; CE07377; NM_072293; WBGene00001210; WP:CE07377 WormBase description: egl-46 encodes a predicted transcription factor and conserved member of a TFIIA-like zinc finger protein family that affects coordinated locomotion, morphology and process formation of the touch cells, male mating efficiency, HSN cell migration, differentiation, and axonal outgrowth, serotonin production and also affects terminal divisions of the Q neuroblasts; acts to inhibit touch cell fate in FLP cells together with egl-44 and is expressed dynamically in neurons, specifically in touch cells, FLP, and HSN neurons. WormBase CDS description: zinc finger protein
                                              
Member of lists (Publications lists):
                                              McCarroll et al 2004  SFig1-4                                     
                                              conserved w/ Drosoph, Portman et al 2004  T1 newly                                 
                                              found ray-genes in25c, Portman et al 2004  T1 25                                   
                                              candidate ray genes, Reinke et al 2004, list of genes                              
                                              in cluster A, Reinke et al 2004, list of genes in                                  
                                              cluster order, ViswanathanM et al 2005  S2 daf-16                                  
                                              Resveratrol                                                                        

K12H4.8 dcr-1 P W All gene names: dcr-1; let-740; K12H4.8; 3J162; CE25057; NM_066360; WBGene00000939; WP:CE25057 WormBase description: The dcr-1 gene encodes a bidentate ribonuclease that is homologous to E. coli RNAse III; dcr-1 is required both for RNA interference and for synthesis of small developmental RNAs; DCR-1 interacts in vivo with RDE-4, a double-stranded RNA (dsRNA) binding protein required for RNAi that interacts with trigger dsRNAs and may function to deliver dsRNAs to DCR-1 for endonucleolytic processing. WormBase CDS description: dead box helicase
                                              
Member of lists (Publications lists):
                                              Jones et al 2001  Non dauer genes                                 
                                              P<0.05, McCarroll et al 2004  SFig1-4 conserved w/                                 
                                              Drosoph, Reinke et al 2004, list of genes in cluster F,                            
                                              Reinke et al 2004, list of genes in cluster order,                                 
                                              Reinke et al 2004, intrinsic, Reinke et al 2004, wt vs                             
                                              glp-4 enriched genes, Reinke et al 2004, wt herm vs wt                             
                                              male enriched gen, ViswanathanM et al 2005  S2 sir-2.1                             
                                              regulated                                                                          

M03D4.1 zen-4 P W All gene names: klp-9; zen-4; M03D4.1; 4G885; CE12344; CE12346; CE31717; CE31718; WBGene00006974; WP:CE12344; WP:CE12346; WP:CE31717; WP:CE31718 WormBase description: zen-4 encodes a kinesin-like protein that is a member of the kinesin-6 subfamily of plus-end-directed microtubule motors; loss-of-function mutations and RNAi experiments indicate that ZEN-4 is required for completion of cytokinesis after mitosis and for polar body extrusion after meiotic divisions; during mitosis, ZEN-4 is detected at the spindle midzone where it co-localizes with spindle microtubules, and ZEN-4 persists at the midbody remnant once cell division is complete; ZEN-4 is also occasionally seen at centrosomes in interphase cells.
                                              
Member of lists (Publications lists):
                                              Reinke et al 2004, intrinsic, Reinke                              
                                              et al 2004, wt vs glp-4 enriched genes, Reinke et al                               
                                              2004, wt herm vs wt male enriched gen, ViswanathanM et                             
                                              al 2005  S2 sir-2.1 regulated                                                      

M05B5.5 hlh-2 P W All gene names: hlh-2; M05B5.5; M05B5.5a.1; M05B5.5a.2; 1H768; CE06191; NM_059633; WBGene00001949; WP:CE06191 WormBase description: hlh-2 encodes a Class I basic helix-loop-helix (bHLH) transcription factor that is the C. elegans ortholog of the mammalian E and Drosophila Daughterless transcriptional activators; HLH-2 activity is required for cell fate specifications occuring during embryonic and larval development that affect such processes as gonadogenesis, male tail formation, and programmed cell death; HLH-2 has been shown to dimerize with at least two C. elegans Acheate-scute homologs, LIN-32, a neural-specific protein with which it functions in male tail development and HLH-3, with which it is coexpressed in the nuclei of embryonic neuronal prescursors and with which it regulates the transcription of the EGL-1 cell death activator in the NSM sister cells; in gonadogenesis, HLH-2 is required for bestowing proAC competence on the cells that undergo the AC/VU (anchor cell/ventral uterine precursor) cell fate decision, for specification, differentiation, and function of the distal tip cell (DTC) and AC, including transcriptional regulation of the LAG-2 Delta-like ligand in the latter, and for formation of the uterine seam cell (utse); genetic analysis also suggests that HLH-2 functions with HLH-14, an additional Acaete-scute homolog, to specify the PVQ/HSN/PHB neuroblast cell lineage; HLH-2 is expressed in all nuclei of early embryos until the ~200-cell stage, when expression becomes increasingly restricted to neuronal cells and their immediate precursors; later expression is detected in, but not limited to, pharyngeal cells, anterior neurons, vulval and uterine muscles, the DTCs, the presumptive and mature AC, the Q neuroblast, and enteric muscles; comparative analysis of transcriptional and translational reporters indicates that hlh-2 is expressed in both the anchor cell and the ventral uterine (VU) precursor, but that expression in the latter is subject to post-transcriptional down-regulation; HLH-2 accumulation in the presumptive AC is the first detectable difference between the AC and VU precursors during the lateral specification event that distinguishes these two cell fates. WormBase CDS description: transcription factor E2-A like
                                              
Member of lists (Publications lists):
                                              McCarroll et al 2004  SFig1-4                                     
                                              conserved w/ Drosoph, Reinke et al 2004, fem1 enriched                             
                                              genes, Reinke et al 2004, wt vs glp-4 enriched genes,                              
                                              Reinke et al 2004, list of genes in cluster order,                                 
                                              Reinke et al 2004, oogenesis enriched genes, Reinke et                             
                                              al 2004, wt herm vs wt male enriched gen, Reinke et al                             
                                              2004, list of genes in cluster E, ViswanathanM et al                               
                                              2005  S2 sir-2.1 regulated                                                         

M117.2 par-5 P W All gene names: ftt-1; par-5; M117.2; M117.2.1; M117.2.2; M117.2.3; 4M586; CE06200; NM_069834; WBGene00003920; WP:CE06200 WormBase description: PAR-5 is a 14-3-3 protein. WormBase CDS description: 14-3-3 protein
                                              
Member of lists (Publications lists):
                                              ViswanathanM et al 2005  S2 sir-2.1                               
                                              regulated, Wang et al 2003  S4 Climbing, Wang et al                                
                                              2003  S3  genes pass one-way ANOVA, Wang et al 2003  S4                            
                                              genes pass two-wayANOVA P0                                                         

M142.1 unc-119 P W All gene names: unc-119; M142.1; 3L997; CE06203; NM_066998; WBGene00006843; WP:CE06203 WormBase description: unc-119 encodes a novel protein that is highly conserved amongst metazoans; unc-119 activity is required for proper development of the nervous system, including axonal branching and fasciculation, and hence, for normal movement, chemosensation, and feeding; unc-119 is expressed pan-neuronally beginning in the early embryo (~60 cells) and continuing through adulthood; although the molecular function of UNC-119 is not yet known, human UNC119, which can rescue C. elegans unc-119 mutant animals, is reported to function as a receptor-associated activator of signal transduction; thus, UNC-119 may be part of a signal transduction pathway that mediates axonal patterning in response to external developmental cues.
                                              
Member of lists (Publications lists):
                                              McCarroll et al 2004  SFig1-4                                     
                                              conserved w/ Drosoph, Romagnolo et al 2002  Fig3b                                  
                                              others, ViswanathanM et al 2005  S2 sir-2.1 regulated                              

MTCE.21 ctb-1 P W All gene names: MTCE16-26; ctb-1; MTCE.21; CE35348; CYB; CYTB; WBGene00000829; WP:CE35348 WormBase description: The ctb-1 gene resides on the mitochondrial chromosome, and encodes the cytochrome b protein of mitochondrial complex III; mutation of ctb-1 suppresses the slow embryonic development of isp-1 mutants, while enhancing their paraquat resistance. WormBase CDS description: cytochrome b
                                              
Member of lists (Publications lists):
                                              ViswanathanM et al 2005  S2 sir-2.1                               
                                              regulated                                                                          

R01H2.6 ubc-18 P W All gene names: ubc-18; R01H2.6; 3I158; CE25067; NM_066140; WBGene00006713; WP:CE25067 WormBase description: ubc-18 encodes an E2 ubiquitin-conjugating enzyme related to human UBCH7 (OMIM:603731); UBC-18 activity is required for normal growth and reproduction, and UBC-18 functions redundantly with LIN-35/Rb and other class B synthetic multivulval (SynMuv) gene products to regulate pharyngeal morphogenesis during embryonic development; ubc-18 transcripts are detected in the germline, embryos, late larval stages, and adults, suggesting that UBC-18 may function maternally to regulate several aspects of C. elegans development; the substrates of UBC-18 are not yet known.
                                              
Member of lists (Publications lists):
                                              McCarroll et al 2004  SFig1-4                                     
                                              conserved w/ Drosoph, Reinke et al 2004, intrinsic,                                
                                              Reinke et al 2004, wt vs glp-4 enriched genes, Reinke                              
                                              et al 2004, GO categories, ViswanathanM et al 2005  S2                             
                                              sir-2.1 regulated                                                                  

R03C1.3 cog-1 P W All gene names: cog-1; R03C1.3; 2P193; CE25964; CE33290; NM_182115; WBGene00000584; WP:CE25964; WP:CE33290 WormBase description: The cog-1 gene encodes an ortholog of a Nkx6.1/Gtx homeodomain protein that affects connection of uterus to the vulva and vulval cell specification.
                                              
Member of lists (Publications lists):
                                              McCarroll et al 2004  SFig1-4                                     
                                              conserved w/ Drosoph                                                               

R06F6.1 cdl-1 P W All gene names: cdl-1; R06F6.1; R06F6.1.1; R06F6.1.2; 2L75; CE01616; NM_063919; WBGene00000411; WP:CE01616; hbp WormBase description: cdl-1 encodes a homolog of human hairpin (stem-loop) binding proteins (HBP/SLBP) that bind to the hairpin (stem-loop) structure in the 3' untranslated region (3' UTR) of histone mRNAs, and thus promote histone pre-mRNA processing and translation of mature histone mRNA; CDL-1 is required for normally high levels of histone gene expression, normal cell division during late larval development, embryonic viability, normal vulval morphogenesis, normally rapid apoptosis, and fertility; CDL-1 binds to the stem-loop structure in the 3' UTR of core-histone mRNA; the cdl-1 promoter is most active in dividing cells during embryogenesis and postembryonic development; both CDL-1 and human HBP contain a minimal RNA-binding domain (RBD) of roughly 73 amino acids that has no similarity with other known RNA-binding motifs.
                                              
Member of lists (Publications lists):
                                              Lund et al 2002  Fig3D Oocyte-en,                                 
                                              McCarroll et al 2004  SFig1-4 conserved w/ Drosoph,                                
                                              Reinke et al 2004, fem1 enriched genes, Reinke et al                               
                                              2004, Fig2b shared gemlines, Reinke et al 2004, list of                            
                                              genes in cluster order, Reinke et al 2004, oogenesis                               
                                              enriched genes, Reinke et al 2004, wt vs glp-4 enriched                            
                                              genes, Reinke et al 2004, wt males vs glp4 male                                    
                                              enriched , Reinke et al 2004, wt herm vs wt male                                   
                                              enriched gen, Reinke et al 2004, list of genes in                                  
                                              cluster E, ViswanathanM et al 2005  S2 sir-2.1                                     
                                              regulated                                                                          

R07E4.4 mig-23 P W All gene names: mig-23; R07E4.4; R07E4.4.1; R07E4.4.2; CE28748; NM_076593; WBGene00003254; WP:CE28748; XG566 WormBase description: guanosine-diphosphatase
                                              
Member of lists (Publications lists):
                                              McCarroll et al 2004  SFig5 conserved                             
                                              w/ yeast, Reinke et al 2004, list of genes in cluster                              
                                              order, Reinke et al 2004, list of genes in cluster B,                              
                                              ViswanathanM et al 2005  S2 sir-2.1 regulated                                      

R09G11.1 sup-10 P W All gene names: sup-10; R09G11.1; CE12656; NM_078434; WBGene00006319; WP:CE12656; XS145
                                              
Member of lists (Publications lists):
                                              ViswanathanM et al 2005  S2 sir-2.1                               
                                              regulated                                                                          

R11E3.6 eor-1 P W All gene names: eor-1; R11E3.6; R11E3.6.1; R11E3.6.2; R11E3.6.3; 4F558; CE19548; NM_068244; WBGene00001324; WP:CE19548 WormBase description: eor-1 encodes an ortholog of the human BTB/zinc-finger transcription factor PLZF (OMIM:176797), which is is found as a retinoic acid receptor alpha (RARA) fusion in acute promyelocytic leukemia (APL); EOR-1 positively regulates RAS/RAF-mediated signalling during excretory system development, as well as RAS/RAF- and WNT-mediated signalling during P12 fate specification; EOR-1 may function with EOR-2 and Hox genes to control the expression of Ras- and Wnt-responsive genes. WormBase CDS description: zinc-finger protein
                                              
Member of lists (Publications lists):
                                              Reinke et al 2004, list of genes in                               
                                              cluster F, Reinke et al 2004, fem1 enriched genes,                                 
                                              Reinke et al 2004, wt vs glp-4 enriched genes, Reinke                              
                                              et al 2004, list of genes in cluster order, Reinke et                              
                                              al 2004, oogenesis enriched genes, Reinke et al 2004,                              
                                              wt herm vs wt male enriched gen, ViswanathanM et al                                
                                              2005  S2 daf-16 Resveratrol                                                        

R12B2.4 him-10 P W All gene names: him-10; R12B2.4; 3G893; CE01367; NM_065852; WBGene00001869; WP:CE01367
                                              
Member of lists (Publications lists):
                                              Reinke et al 2004, intrinsic, Reinke                              
                                              et al 2004, list of genes in cluster F, Reinke et al                               
                                              2004, wt vs glp-4 enriched genes, Reinke et al 2004,                               
                                              list of genes in cluster order, Reinke et al 2004, wt                              
                                              herm vs wt male enriched gen                                                       

R13A5.1 cup-5 P W All gene names: cup-5; muc-1; R13A5.1; R13A5.1a.1; R13A5.1a.2; 3I679; CE30111; CE30387; CE34585; CE34586; NM_066263; WBGene00000846; WP:CE30111; WP:CE30387; WP:CE34585; WP:CE34586 WormBase description: The cup-5 gene encodes an ortholog of the human mucolipin-1 gene, and is required for the normal, negative regulation of endocytotic uptake of markers from pseudocoelomic fluid.
                                              
Member of lists (Publications lists):
                                              McCarroll et al 2004  SFig1-4                                     
                                              conserved w/ Drosoph, Reinke et al 2004, intrinsic,                                
                                              Reinke et al 2004, list of genes in cluster F, Reinke                              
                                              et al 2004, wt vs glp-4 enriched genes, Reinke et al                               
                                              2004, list of genes in cluster order, Reinke et al                                 
                                              2004, wt herm vs wt male enriched gen, ViswanathanM et                             
                                              al 2005  S2 sir-2.1 regulated                                                      

SLE-1 slo-1 P W All gene names: SLE-1; slo-1; WBGene00004828
T01C4.2 odr-2 P W All gene names: odr-2; T01C4.2; 5H593; CE28348; CE28349; CE28350; WBGene00003849; WP:CE28348; WP:CE28349; WP:CE28350 WormBase description: odr-2 encodes three isoforms of a predicted membrane-associated protein related to the Ly-6 (leukocyte antigen-6) family of GPI (glycosylated phosphatidylinositol)-linked signaling proteins; ODR-2 activity is required for proper functioning of the AWC olfactory neurons and thus for chemotaxis in response to AWC-sensed odorants; ODR-2 is expressed at high levels in sensory neurons, motor neurons, and interneurons, where it appears to be enriched in axons.
T01H8.5 gon-2 P W All gene names: gon-2; T01H8.5; 1J126; CE30390; NM_059914; WBGene00001651; WP:CE30390 WormBase description: The gon-2 gene encodes a predicted transmembrane cation channel homologous to the long transient receptor potential channel (LTRPC) subfamily of TRP channels including Drosophila DLTRP and mammalian melastatin and LTRPC7; GON-2 regulates the onset and continuation of post-embryonic mitotic cell divisions in the somatic gonad precursor cells perhaps by mediating an increase in intracellular calcium in response to activating signals. WormBase CDS description: transient receptor protein
T02C5.5 unc-2 P W All gene names: unc-2; T02C5.5; T02C5.5d.1; T02C5.5d.2; T02C5.5d.3; CE29459; CE31225; CE34591; CE34980; NM_171638; NM_171639; NM_171942; WBGene00006742; WP:CE29459; WP:CE31225; WP:CE34591; WP:CE34980; XD330 WormBase description: unc-2 encodes a calcium channel alpha subunit required for desensitization to dopamine, normal flexion and speed during movement, normally low sensitivity of whole animals to serotonin, and neuronal migrations promoted by humoral serotonin; UNC-2 is orthologous to human CACNA1A (OMIM:601011, mutated in familiar hemiplegic migraine or episodic ataxia 2) and to Drosophila CACOPHONY; UNC-2 is expressed primarily in motor neurons, several sensory neurons, and HSN and VC neurons controlling egg-laying.
                                              
Member of lists (Publications lists):
                                              McCarroll et al 2004  SFig1-4                                     
                                              conserved w/ Drosoph, Reinke et al 2004, list of genes                             
                                              in cluster A, Reinke et al 2004, list of genes in                                  
                                              cluster order                                                                      

T05A10.1 sma-9 P W All gene names: sma-9; T05A10.1; T05A10.1h.1; T05A10.1h.2; T05A10.1k.1; T05A10.1k.2; T05A10.1k.3; CE36395; CE36396; CE36397; CE36398; CE36399; CE36400; CE36401; CE36402; CE36403; CE36404; CE39627; NM_171771; NM_171772; WBGene00004862; WP:CE36395; WP:CE36396; WP:CE36397; WP:CE36398; WP:CE36399; WP:CE36400; WP:CE36401; WP:CE36402; WP:CE36403; WP:CE36404; WP:CE39627; XL401 WormBase description: sma-9 encodes, by alternative splicing, at least two large (~2000-residue) protein with at least three N-terminal involucrin domains, seven C-terminal zinc-finger domains, and a glutamine/asparagine-rich domain; SMA-9 is orthologous to human HIVEP1 (OMIM:194540), HIVEP2 (OMIM:143054), and HIVEP3 (OMIM:606649), and to Drosophila SCHNURRI (FBgn0003396); SMA-9 proteins are required for growth to normally large body size.
                                              
Member of lists (Publications lists):
                                              McCarroll et al 2004  SFig1-4                                     
                                              conserved w/ Drosoph, ViswanathanM et al 2005  S2                                  
                                              sir-2.1 regulated                                                                  

T05H4.14 gad-1 P W All gene names: gad-1; tag-86; T05H4.14; 5G912; CE13295; NM_072234; WBGene00001513; WP:CE13295 WormBase description: The gad-1 gene encodes a WD repeat-containing protein that is required maternally for gastrulation initiation during early embryogenesis by regulating the division timing, spindle orientation, and subsequent inward migration of the two gut precusor (E) cells at the 26-cell stage.
                                              
Member of lists (Publications lists):
                                              McCarroll et al 2004  SFig1-4                                     
                                              conserved w/ Drosoph, Reinke et al 2004, fem1 enriched                             
                                              genes, Reinke et al 2004, wt vs glp-4 enriched genes,                              
                                              Reinke et al 2004, list of genes in cluster order,                                 
                                              Reinke et al 2004, oogenesis enriched genes, Reinke et                             
                                              al 2004, wt herm vs wt male enriched gen, Reinke et al                             
                                              2004, list of genes in cluster E, ViswanathanM et al                               
                                              2005  S2 sir-2.1 regulated                                                         

T07A9.5 eri-1 P W All gene names: eri-1; T07A9.5; 4B170; CE17214; CE30163; NM_171244; NM_171245; WBGene00001332; WP:CE17214; WP:CE30163
                                              
Member of lists (Publications lists):
                                              Reinke et al 2004, intrinsic, Reinke                              
                                              et al 2004, wt vs glp-4 enriched genes, Reinke et al                               
                                              2004, wt herm vs wt male enriched gen, ViswanathanM et                             
                                              al 2005  S2 sir-2.1 regulated                                                      

T09A5.10 lin-5 P W All gene names: lin-5; T09A5.10; T09A5.10.1; T09A5.10.2; 2I153; CE18951; NM_063253; WBGene00002994; WP:CE18951 WormBase description: lin-5 encodes a novel protein with a centrally located alpha-helical coiled-coil domain and ten potential proline-directed kinase phosphorylation sites; LIN-5 activity is required for mitosis and cytokinesis at all stages of development and specifically, for spindle positioning, chromosome alignment and segregation, and perhaps also for blocking exit from mitosis when chromosome segregation fails; LIN-5, which is expressed maternally, embryonically, and during larval stages, localizes to the cell periphery and, in a microtubule-dependent manner, to the meiotic spindle and the asters and kinetochore microtubules of the mitotic spindle; in regulating spindle function, LIN-5 interacts with two G protein regulators, GPR-1 and GPR-2, which require LIN-5 activity for localization to the spindle and cell cortex; additionally, LIN-5 interacts in vitro with itself, the coiled-coil protein LFI-1, GEI-16, and several other novel proteins; genetic studies indicate that in regulating embryonic spindle function, lin-5 acts downsteam of par-2, par-3, mes-1, and src-1 and upstream of gpr-1, gpr-2, goa-1, and gpa-16.
                                              
Member of lists (Publications lists):
                                              Reinke et al 2004, list of genes in                               
                                              cluster F, Reinke et al 2004, fem1 enriched genes,                                 
                                              Reinke et al 2004, wt vs glp-4 enriched genes, Reinke                              
                                              et al 2004, list of genes in cluster order, Reinke et                              
                                              al 2004, oogenesis enriched genes, Reinke et al 2004,                              
                                              wt herm vs wt male enriched gen, ViswanathanM et al                                
                                              2005  S2 sir-2.1 regulated                                                         

T10A3.1 unc-10 P W All gene names: rim-1; unc-10; T10A3.1; CE30169; CE31234; NM_171720; WBGene00006750; WP:CE30169; WP:CE31234; XH892 WormBase description: unc-10 encodes a protein with zinc-finger, Q/N-rich, PDZ, and C2 domains that is homologous to vertebrate Rim1, a presynaptic protein which binds, and effects the activity of, synaptic vesicle-associated GTP-Rab3; UNC-10 is required for normal locomotion and synaptic transmission, and localizes to a subdomain of presynaptic termini, where it probably acts to regulate the priming step of presynaptic vesicle fusion by promoting conformational changes in syntaxin.
                                              
Member of lists (Publications lists):
                                              McCarroll et al 2004  SFig1-4                                     
                                              conserved w/ Drosoph, ViswanathanM et al 2005  S2                                  
                                              sir-2.1 regulated                                                                  

T10H9.4 snb-1 P W All gene names: snb-1; T10H9.4; 5H136; CE18252; NM_072287; VAMP/1; WBGene00004897; WP:CE18252 WormBase description: The snb-1 gene encodes synaptobrevin, a synaptic vesicle protein orthologous to human vesicle-associated membrane protein 1 (VAMP1 OMIM:185880) and 2 (VAMP2 OMIM:185881), and is required for viability and synaptic transmission; SNB-1 is likely to play a role in vesicle docking and/or fusion and is expressed in neurons where it colocalizes with synaptic vesicle proteins RAB-3 and synaptotagmin. WormBase CDS description: synaptobrevin
                                              
Member of lists (Publications lists):
                                              McCarroll et al 2004  SFig1-4                                     
                                              conserved w/ Drosoph, ViswanathanM et al 2005  S2                                  
                                              sir-2.1 regulated                                                                  

T12A7.1 gem-4 P W All gene names: gem-4; tag-121; T12A7.1; T12A7.1.1; T12A7.1.2; 4M511; CE27445; NM_069824; WBGene00001577; WP:CE27445 WormBase description: gem-4 encodes a Ca[2+]-dependent phosphatidylserine binding protein (copine) that antagonizes GON-2 in gonadal cell division, with no other obvious function in normal animals; GEM-4 is highly similar to three human proteins, copine I, copine III, and KIA1599 (40% identity over 590 residues); GEM-4 is also similar to its C. elegans paralog, F26D10.4 (73% identity over 637 residues), with at least three other copines being encoded by the C. elegans genome; since both GEM-4 and GON-2 are predicted to be plasma membrane proteins, they may interact directly. WormBase CDS description: C2 domain (2 domains)
T12G3.8 bre-5 P W All gene names: bre-5; T12G3.8; 4M814; CE30354; NM_171420; WBGene00000270; WP:CE30354 WormBase description: The bre-5 gene encodes a putative beta-1,3-galactosyltransferase that is predicted to transfer galactose onto proteins or lipids; BRE-5 is required for Cry5B toxicity. WormBase CDS description: beta-1,3-galactosyltransferase
T13F2.1 fat-4 P W All gene names: fat-4; T13F2.1; T13F2.1.1; T13F2.1.2; T13F2.1.3; 4K565; CE25113; NM_069350; WBGene00001396; WP:CE25113 WormBase description: fat-4 encodes a delta-5 fatty acid desaturase; when expressed heterologously in S. cerevisiae, FAT-4 converts di-homo-gamma-linolenic acid (20:3delta8,11,14) to arachidonic acid (20:4delta5,8,11,14), an important precursor in eicosanoid metabolism, as well as on other fatty acids (C18 to C20); FAT-4 is is required in vivo for delta-5 unsaturated fatty acid synthesis. WormBase CDS description: cytochrome B5 containing fusion protein
                                              
Member of lists (Publications lists):
                                              McElwee et al 2003  T1 targets of                                 
                                              daf-16, ViswanathanM et al 2005  S2 sir-2.1 regulated                              

T18D3.2 odr-7 P W All gene names: odr-7; T18D3.2; CE03663; NM_077688; WBGene00003854; WP:CE03663; XN78 WormBase description: The odr-7 gene encodes an olfactory specific member of the nuclear receptor superfamily that affects chemotaxis to some volatile odorants and the cell fate of the AWA neuron; it is expressed in AWA neurons. WormBase CDS description: Zinc finger, C4 type (two domains)
T20G5.11 rde-4 P W All gene names: rde-4; T20G5.11; T20G5.11.1; T20G5.11.2; 3L306; CE00630; NM_066864; WBGene00004326; WP:CE00630 WormBase description: Double-stranded RNA binding motif
                                              
Member of lists (Publications lists):
                                              Lund et al 2002   Fig3C                                           
                                              Germline-intrinsic, Reinke et al 2004, list of genes in                            
                                              cluster F, Reinke et al 2004, fem1 enriched genes,                                 
                                              Reinke et al 2004, list of genes in cluster order,                                 
                                              Reinke et al 2004, oogenesis enriched genes, Reinke et                             
                                              al 2004, wt vs glp-4 enriched genes, Reinke et al 2004,                            
                                              wt herm vs wt male enriched gen, Reinke et al 2004, GO                             
                                              categories, ViswanathanM et al 2005  S2 sir-2.1                                    
                                              regulated                                                                          

T21D12.4 pat-6 P W All gene names: pat-6; T21D12.4; 4B16; CE18268; NM_067490; WBGene00003932; WP:CE18268 WormBase description: pat-6 encodes the worm ortholog of alpha-parvin; it is required for muscle assembly and function, with mutations leading to embryonic lethality.
                                              
Member of lists (Publications lists):
                                              McCarroll et al 2004  SFig1-4                                     
                                              conserved w/ Drosoph, Reinke et al 2004, list of genes                             
                                              in cluster order, Reinke et al 2004, list of genes in                              
                                              cluster B                                                                          

T22B7.1 egl-13 P W All gene names: cog-2; egl-13; T22B7.1; T22B7.1a.1; T22B7.1a.2; T22B7.1b.1; T22B7.1b.2; T22B7.1b.3; T22B7.1b.4; T22B7.1c.1; T22B7.1c.2; T22B7.1c.3; CE05030; CE28487; CE33702; CE38552; NM_076554; WBGene00001182; WP:CE05030; WP:CE28487; WP:CE33702; WP:CE38552; XG291 WormBase description: egl-13 encodes a transcription factor of the HMG (high mobility group) box family that affects the cell fusion process that makes the vulval-uterine connection and thereby affects egg laying; expressed in the pi lineage cells, transiently expressed in the rho lineage, in the anchor cell following fusion, and in neurons, body wall muscles, and intestinal cells.
                                              
Member of lists (Publications lists):
                                              Reinke et al 2004, list of genes in                               
                                              cluster order, Reinke et al 2004, herm soma enriched                               
                                              genes, Reinke et al 2004, list of genes in cluster B,                              
                                              Romagnolo et al 2002  Fig3b Unkown                                                 

T22C8.8 vab-9 P W All gene names: vab-9; T22C8.8; 2I924; CE32938; NM_063435; WBGene00006875; WP:CE32938 WormBase description: vab-9 encodes a claudin homolog orthologous to human brain cell membrane protein 1 (BCMP1) and Drosophila CG6982; VAB-9 colocalizes with HMP-1 to an apical layer of the adherens junctions of all epithelial cells, one layer more apically than AJM-1; vab-9 mutants have disorganized F-actin at the adherens junction, implying that VAB-9 links junctions to circumferential actin filaments; VAB-9 is also expressed in the nerve ring; VAB-9 requires the cadherin HMR-1 to localize to the cell membrane, and both alpha-catenin (HMP-1) and beta-catenin (HMP-2) to remain at the cell junction after membrane localization.
                                              
Member of lists (Publications lists):
                                              McCarroll et al 2004  SFig1-4                                     
                                              conserved w/ Drosoph, Reinke et al 2004, list of genes                             
                                              in cluster A, Reinke et al 2004, list of genes in                                  
                                              cluster order, ViswanathanM et al 2005  S2 sir-2.1                                 
                                              regulated, ViswanathanM et al 2005  S2 daf-16                                      
                                              Resveratrol                                                                        

T23D8.8 cfi-1 P W All gene names: cfi-1; T23D8.8; 1K570; CE31068; NM_060243; WBGene00000476; WP:CE31068 WormBase description: cfi-1 encodes a DNA-binding protein containing an AT-rich interaction domain (ARID) that affects differentiation of the URA sensory neurons, AVD, and PVC interneurons; acts downstream of UNC-86 and LIN-32 in controlling URA and IL2 cell fate, and is expressed in some neurons and muscle cells. WormBase CDS description: ARID DNA-binding protein
                                              
Member of lists (Publications lists):
                                              McCarroll et al 2004  SFig1-4                                     
                                              conserved w/ Drosoph, ViswanathanM et al 2005  S2                                  
                                              sir-2.1 regulated                                                                  

T25C12.1 lin-14 P W All gene names: lin-14; T25C12.1; CE03733; CE03734; NM_077515; NM_077516; WBGene00003003; WP:CE03733; WP:CE03734; XM103 WormBase description: lin-14 encodes a novel protein whose activity is required for specifying the division timings of a specific group of cells during postembryonic development; lin-14 loss-of-function mutations result in the premature appearance of later larval lineages, while gain-of-function mutations result in reiteration of L1 larval stages lineages; in addition, lin-14 acts as a positive regulator of AVM, PVM, and FLP touch cell development; in regulating developmental timing, lin-14 acts, in part, by positively regulating the activity of lin-28, which encodes a cytoplasmic protein also required for proper developmental timing; at hatching, LIN-14 is detected in the nuclei of blast cells and neurons; later, from the late L1 to adult stages, LIN-14 levels are negatively regulated by translational repression mediated by lin-4, a 22-nt small temporal RNA (stRNA) that is complementary to sequences in the lin-14 3' UTR. WormBase CDS description: embryonic nuclear protein lin-14 form A
                                              
Member of lists (Publications lists):
                                              ViswanathanM et al 2005  S2 sir-2.1                               
                                              regulated                                                                          

T28D6.9 pen-2 P W All gene names: pen-2; T28D6.9; 3M433; CE24023; NM_067058; WBGene00003975; WP:CE24023
T28F12.2 unc-62 P W All gene names: ceh-25; let-328; nob-5; unc-62; T28F12.2; T28F12.2a.1; T28F12.2a.2; T28F12.2d.1; T28F12.2d.2; T28F12.2d.3; T28F12.2g.1; T28F12.2g.2; T28F12.2g.3; T28F12.2g.4; T28F12.2g.5; 5E989; CE21219; CE21220; CE31073; CE31074; CE33584; CE33585; CE37795; WBGene00006796; WP:CE21219; WP:CE21220; WP:CE31073; WP:CE31074; WP:CE33584; WP:CE33585; WP:CE37795 WormBase description: unc-62 encodes a Meis-class homeodomain protein required for posterior embryonic morphogenesis, male tail morphogenesis, commissure formation by VD and DD motor neurons, vulval morphogenesis, and normal locomotion; UNC-62 is orthologous to Drosophila HOMOTHORAX; both maternal-effect unc-62 alleles and the zygotic lethal unc-62(s472) allele phenotypically resemble mutations of the caudal ortholog pal-1; RNAi of the Pbc-class ceh-20 and ceh-40 homeodomain genes strongly enhances the hypomorphic unc-62(e644) allele to give either a strong loss-of-function or null-like phenotype, while overexpression of ceh-20 enhances the lethality of some unc-62 alleles.
T28F12.3 sos-1 P W All gene names: let-341; sos-1; T28F12.3; T28F12.B; Y61A9LA_73.A; 5E996; CE36328; NM_071834; WBGene00004947; WP:CE36328 WormBase description: The sos-1 gene, also known as let-341, encodes an ortholog of Son of sevenless, a guanine nucleotide exchange factor that affects viability, sex myoblast migration, vulval induction, and oogenesis; it acts genetically downstream of let-23 and upstream of let-60 with respect to vulval development.
                                              
Member of lists (Publications lists):
                                              Romagnolo et al 2002  Fig3b signaling                             

VF36H2L.1 aph-1 P W All gene names: aph-1; pen-1; VF36H2L.1; 1J808; CE16526; NM_060068; WBGene00000147; WP:CE16526 WormBase description: aph-1 encodes an unfamiliar protein predicted to have seven transmembrane domains; APH-1 is a component of the GLP-1/LIN-12 (Notch) pathway, is required maternally for embryonic viability, and also affects morphogenesis, egg laying, germ line proliferation, and translocation of APH-2 to the cell surface; with PEN-2, APH-1 is required for Notch pathway signaling, gamma-secretase cleavage of beta-amyloid precursor protein, and presenilin protein accumulation.
                                              
Member of lists (Publications lists):
                                              McCarroll et al 2004  SFig1-4                                     
                                              conserved w/ Drosoph, Reinke et al 2004, intrinsic,                                
                                              Reinke et al 2004, wt vs glp-4 enriched genes, Reinke                              
                                              et al 2004, list of genes in cluster order, Reinke et                              
                                              al 2004, wt herm vs wt male enriched gen, Reinke et al                             
                                              2004, list of genes in cluster E, ViswanathanM et al                               
                                              2005  S2 sir-2.1 regulated                                                         

W02A2.1 fat-2 P W All gene names: fat-2; W02A2.1; 4O89; CE21231; NM_070159; WBGene00001394; WP:CE21231 WormBase description: The fat-2 gene encodes a delta-12 fatty acyl desaturase that increases membrane fluidity when expressed in yeast, and that may protect against cold stress; FAT-2's substrate is unknown, but may be acyl-CoA; FAT-2 is required in vivo for normal levels of C18 or C20 polyunsaturated fatty acids (PUFAs); FAT-2 is also required for a normally fast growth rate and movement rate, and for normal body shape, defecation rhythm, and brood size. WormBase CDS description: Fatty acid desaturase
                                              
Member of lists (Publications lists):
                                              ViswanathanM et al 2005  S2 sir-2.1                               
                                              regulated                                                                          

W02D3.3 mec-6 P W All gene names: mec-6; W02D3.3; 1H303; CE31080; NM_059524; WBGene00003170; WP:CE31080 WormBase description: mec-6 is homologous to the human PARAOXONASE 1 gene (PON1, OMIM:168820), which in some allelic forms is associated with susceptibility to coronary artery disease; MEC-6 protein interacts physically with the MEC-4 degenerin ion channel, is colocalized with it in vivo, and is required for MEC-4 punctate expression along touch-receptor neural processes. WormBase CDS description: paraoxonase/arylesterase
                                              
Member of lists (Publications lists):
                                              Jones et al 2001  Non dauer genes                                 
                                              P<0.05                                                                             

W02D3.8 smg-5 P W All gene names: mab-15; smg-5; W02D3.8; 1H310; CE25134; NM_059528; WBGene00004883; WP:CE25134
                                              
Member of lists (Publications lists):
                                              Reinke et al 2004, fem1 enriched                                  
                                              genes, Reinke et al 2004, wt vs glp-4 enriched genes,                              
                                              Reinke et al 2004, oogenesis enriched genes, Reinke et                             
                                              al 2004, wt herm vs wt male enriched gen, ViswanathanM                             
                                              et al 2005  S2 daf-16 Resveratrol                                                  

W02D3.9 unc-37 P W All gene names: let-76; unc-37; W02D3.9; W02D3.9.1; W02D3.9.2; W02D3.9.3; 1H320; CE14434; ESG; NM_059531; WBGene00006773; WP:CE14434 WormBase description: The unc-37 gene encodes a transducin-like WD-repeat protein homologous to Drosophila GROUCHO that genetically interacts with components of the transcriptional Mediator complex. WormBase CDS description: transducin-like enhancer protein
                                              
Member of lists (Publications lists):
                                              McCarroll et al 2004  SFig1-4                                     
                                              conserved w/ Drosoph, Reinke et al 2004, fem1 enriched                             
                                              genes, Reinke et al 2004, wt vs glp-4 enriched genes,                              
                                              Reinke et al 2004, list of genes in cluster order,                                 
                                              Reinke et al 2004, oogenesis enriched genes, Reinke et                             
                                              al 2004, wt herm vs wt male enriched gen, Reinke et al                             
                                              2004, list of genes in cluster E, ViswanathanM et al                               
                                              2005  S2 sir-2.1 regulated                                                         

W06H8.1 rme-1 P W All gene names: rme-1; W06H8.1; W06H8.1f.1; W06H8.1f.2; W06H8.1f.3; 5G697; CE25146; CE25147; CE25148; CE30204; CE31086; CE33335; WBGene00004373; WP:CE25146; WP:CE25147; WP:CE25148; WP:CE30204; WP:CE31086; WP:CE33335 WormBase description: The rme-1 gene encodes a C. elegans protein required for endocytosis.
W08D2.1 egl-20 P W All gene names: egl-20; W08D2.1; 4K578; CE25152; NM_069353; WBGene00001188; WP:CE25152 WormBase description: egl-20 encodes a member of the WNT family of developmental signaling proteins that affects migration of QL and QR and their descendents; expressed in muscle and epidermal cells at the posterior of the worm. WormBase CDS description: WNT protein
                                              
Member of lists (Publications lists):
                                              ViswanathanM et al 2005  S2 sir-2.1                               
                                              regulated                                                                          

W08D2.4 fat-3 P W All gene names: fat-3; W08D2.4; 4K569; CE25153; NM_069351; WBGene00001395; WP:CE25153 WormBase description: The fat-3 gene encodes a delta-6 fatty acid desaturase ('linoleoyl-CoA desaturase') containing an N-terminal cytochrome b5 domain; FAT-3 expressed in yeast uses linoleic and alpha-linolenic acid as substrates; FAT-3 is absolutely required in vivo for synthesis of delta-6 fatty acids, and also required for fully normal synthesis of C20 fatty acids; FAT-3 is required for a normally fast growth rate and movement speed, and for normal defecation rhythms and fertility.
                                              
Member of lists (Publications lists):
                                              Murphy et al 2003  Fig2 Class1                                    
                                              elongate lifespan, Reinke et al 2004, list of genes in                             
                                              cluster A, Reinke et al 2004, list of genes in cluster                             
                                              order, ViswanathanM et al 2005  S2 sir-2.1 regulated                               

W09C5.2 unc-59 P W All gene names: unc-59; unc-88; W09C5.2; W09C5.2.1; W09C5.2.2; 1O225; CE20165; NM_060987; WBGene00006793; WP:CE20165 WormBase description: unc-59, by alternative splicing, encodes two septin isoforms required (like the septins UNC-61A/B) for normal axonal migration, distal tip cell migration, and postembryonic cytokinesis (at the cellular level) and for normal locomotion and formation of the postembryonic vulva, somatic gonad, and male tail (at the organismal level); both UNC-59 and UNC-61A/B are dispensable for embryonic cytokinesis and development, but are thought to be required for all postembryonic cytokinesis; UNC-59 and UNC-61A/B depend on each other for localization to the cytokinetic furrow. WormBase CDS description: Cell division protein
                                              
Member of lists (Publications lists):
                                              McCarroll et al 2004  SFig1-4                                     
                                              conserved w/ Drosoph, Reinke et al 2004, fem1 enriched                             
                                              genes, Reinke et al 2004, wt vs glp-4 enriched genes,                              
                                              Reinke et al 2004, list of genes in cluster order,                                 
                                              Reinke et al 2004, oogenesis enriched genes, Reinke et                             
                                              al 2004, wt herm vs wt male enriched gen, Reinke et al                             
                                              2004, list of genes in cluster E, ViswanathanM et al                               
                                              2005  S2 sir-2.1 regulated                                                         

W10C6.1 mat-2 P W All gene names: apc-1; evl-22; mat-2; pod-3; W10C6.1; 2L409; CE21288; NM_063982; WBGene00003133; WP:CE21288 WormBase description: mat-2 encodes a subunit of the anaphase-promoting complex or cyclosome (APCC) which is a multi-subunit E3 ubiquitin ligase that targets proteins for degradation during the metaphase-to-anaphase transition of the cell cycle; mat-2 is required for chromosome segregation during meiosis I and is involved in polarity specification of the anterior/posterior axis in the developing embryo.
                                              
Member of lists (Publications lists):
                                              McCarroll et al 2004  SFig1-4                                     
                                              conserved w/ Drosoph, Reinke et al 2004, list of genes                             
                                              in cluster F, Reinke et al 2004, fem1 enriched genes,                              
                                              Reinke et al 2004, list of genes in cluster order,                                 
                                              Reinke et al 2004, oogenesis enriched genes, Reinke et                             
                                              al 2004, wt vs glp-4 enriched genes, Reinke et al 2004,                            
                                              wt herm vs wt male enriched gen, ViswanathanM et al                                
                                              2005  S2 sir-2.1 regulated                                                         

W10C8.2 pop-1 P W All gene names: pop-1; sys-2; W10C8.2; 1D392; CE26031; NM_058652; WBGene00004077; WP:CE26031 WormBase description: pop-1 encodes an HMG box-containing protein that is the sole C. elegans member of the TCF/LEF family of transcription factors; in C. elegans, POP-1 functions as a component of the canonical and noncanonical Wnt signaling pathways that are required for cell migrations and binary cell fate decisions associated with asymmetric cell division, respectively; in yeast two-hybrid assays, the POP-1 N-terminal beta-catenin binding domain interacts with BAR-1/beta-catenin as well as with the more divergent beta-catenin, SYS-1; when coexpressed with SYS-1, POP-1 is able to activate transcription from a promoter with TCF binding sites; during development, maternally provided POP-1 is first detected in the nuclei of maturing oocytes and then in nearly all cells of the early embryo; in sister blastomeres in the early embryo, POP-1 is detected at lower levels in posterior blastomeres, such as E and P3, than in corresponding anterior blastomeres, MS and C; in later developmental stages, POP-1 is detected in a subset of tissues including hypodermal seam cells, gonadal precursors, and the developing vulva; in the vulva, POP-1 also exhibits an asymmetric staining pattern, with sister cells showing high or low levels of POP-1 depending upon their orientation along the anterior/posterior axis of the vulva.
                                              
Member of lists (Publications lists):
                                              McCarroll et al 2004  SFig1-4                                     
                                              conserved w/ Drosoph, Reinke et al 2004, list of genes                             
                                              in cluster order, Reinke et al 2004, list of genes in                              
                                              cluster E                                                                          

W10G6.3 mua-6 P W All gene names: ifa-2; mua-6; W10G6.3; W10G6.3.1; W10G6.3.2; CE18354; Cel IF A2; CelIF a2; NM_078247; WBGene00003485; WP:CE18354; XQ878 WormBase description: mua-6 encodes an essential intermediate filament protein (MUA-6/IFA-2) that is coexpressed with the essential IF protein IFB-1; MUA-6 is required for hypodermal integrity and for lasting attachment of muscles to the body wall; MUA-6 is also required for normal positioning of excretory canals and muscles; MUA-6 forms heteropolymeric intermediate filaments in vitro with an equimolar mixture of IFB-1; mua-6 is transcribed from L1 larval to adult stages; MUA-6 resides in main body hypodermal desmosomes, but not in seam cells. WormBase CDS description: intermediate filament protein
                                              
Member of lists (Publications lists):
                                              Murphy et al 2003  Fig2 Class1                                    
                                              elongate lifespan, Reinke et al 2004, list of genes in                             
                                              cluster order, Reinke et al 2004, list of genes in                                 
                                              cluster C, Reinke et al 2004, IVb male soma enriched                               
                                              genes, Wang et al 2003  S4 Climbing, Wang et al 2003                               
                                              S3  genes pass one-way ANOVA, Wang et al 2003  S4 genes                            
                                              pass two-wayANOVA P0                                                               

Y105E8A.7 eat-18 P W All gene names: eat-18; lev-10; Y105E8A.7; Y105E8E.F; 1O991; CE29845; CE33723; CE36334; CE37055; WBGene00001147; WBGene00002977; WP:CE29845; WP:CE33723; WP:CE36334; WP:CE37055 WormBase description: eat-18 encodes a predicted novel transmembrane protein; EAT-18 is required for proper nicotinic neurotransmission by the MC pharyngeal neuron and thus, for regulation of the pharyngeal pumping rate; EAT-18 is also required for alpha-bungarotoxin-binding to most or all pharyngeal nicotinic receptors; an EAT-18::GFP fusion protein is expressed in pharyngeal muscle, the M5 pharyngeal motor neuron, and five to six unidentified extrapharyngeal neurons; eat-18 interacts genetically with eat-2, which encodes a non-alpha nicotonic acetylcholine receptor subunit expressed in pharyngeal muscle and also required for proper regulation of the pharyngeal pumping rate.
                                              
Member of lists (Publications lists):
                                              Reinke et al 2004, list of genes in                               
                                              cluster order, Reinke et al 2004, list of genes in                                 
                                              cluster C                                                                          

Y106G6E.5 ced-12 P W All gene names: ced-12; mig-16; Y106G6E.5; Y106G6E.5.1; Y106G6E.5.2; 1K800; CE27228; NM_060292; WBGene00000426; WP:CE27228 WormBase description: ced-12 is required both for phagocytotic engulfment of dying (apoptotic) cells, and for normal migrations of healthy cells during development.
                                              
Member of lists (Publications lists):
                                              McCarroll et al 2004  SFig1-4                                     
                                              conserved w/ Drosoph, ViswanathanM et al 2005  S2                                  
                                              sir-2.1 regulated                                                                  

Y110A2AL.14 sqv-2 P W All gene names: sqv-2; Y110A2AL.14; Y110A2A_1898.B; 2D180; CE25190; NM_061993; WBGene00005020; WP:CE25190 WormBase description: sqv-2 encodes a glycosaminoglycan galactosyltransferase II, biochemically active in vitro, that is required for cytokinesis of one-cell embryos and for vulval morphogenesis; the common requirement for SQV-2 in both cytokinesis and morphogenesis may be to promote filling an extracellular space with hygroscopic proteoglycans (either in the eggshell, or underneath the L4 cuticle), which in turn may cause the space to fill with fluid.
                                              
Member of lists (Publications lists):
                                              McCarroll et al 2004  SFig1-4                                     
                                              conserved w/ Drosoph, ViswanathanM et al 2005  S2                                  
                                              sir-2.1 regulated                                                                  

Y113G7A.3 sec-23 P W All gene names: sec-23; Y113G7A.3; Y113G7A.3.1; Y113G7A.3.2; 5U575; CE27230; NM_075476; WBGene00004754; WP:CE27230
                                              
Member of lists (Publications lists):
                                              McCarroll et al 2004  SFig5 conserved                             
                                              w/ yeast, McCarroll et al 2004  SFig1-4 conserved w/                               
                                              Drosoph                                                                            

Y113G7A.6 ttx-1 P W All gene names: ttx-1; Y113G7A.6; 5U524; CE31090; CE31091; WBGene00006652; WP:CE31090; WP:CE31091
                                              
Member of lists (Publications lists):
                                              ViswanathanM et al 2005  S2 sir-2.1                               
                                              regulated                                                                          

Y2H9A.1 mes-4 P W All gene names: mes-4; Y2H9A.1; 5N914; CE27781; NM_073932; WBGene00003222; WP:CE27781 WormBase description: mes-4 encodes a SET domain-containing protein that also contains three plant homeodomain (PHD) fingers; MES-4 is required maternally for normal germline development, but in contrast to MES-2, -3, and -6, does not appear to be required for somatic anteroposterior patterning; in germline development, MES-4 activity is essential for regulating active chromatin states and for excluding the MES-2/MES-3/MES-6 chromatin repression complex from the autosomes; MES-4 is also required for germline silencing of repetitive transgene arrays; MES-4 localizes to autosomes, and is detectable in the distal, mitotic region of the germline, in meiotic germ cells during late pachytene, and in oocytes; MES-4 is detected in all somatic and germline nuclei of the early embryo, but by the 100-cell stage, its expression becomes restricted to the primordial germ cells, Z2 and Z3; exclusion of MES-4 from X chromosomes requires the activity of the MES-2, -3, -6 complex WormBase CDS description: SET domain
                                              
Member of lists (Publications lists):
                                              Reinke et al 2004, list of genes in                               
                                              cluster F, Reinke et al 2004, fem1 enriched genes,                                 
                                              Reinke et al 2004, wt vs glp-4 enriched genes, Reinke                              
                                              et al 2004, list of genes in cluster order, Reinke et                              
                                              al 2004, oogenesis enriched genes, Reinke et al 2004,                              
                                              wt herm vs wt male enriched gen                                                    

Y34B4A.3 hst-6 P W All gene names: hst-6; Y34B4A.3; CE32011; NM_076494; WBGene00002031; WP:CE32011; XF895
                                              
Member of lists (Publications lists):
                                              McCarroll et al 2004  SFig1-4                                     
                                              conserved w/ Drosoph, ViswanathanM et al 2005  S2                                  
                                              sir-2.1 regulated                                                                  

Y37D8A.13 unc-71 P W All gene names: adm-1; max-3; unc-71; Y37D8A.13; 3N972; CE20217; NM_067279; WBGene00006804; WP:CE20217 WormBase description: unc-71 encodes an ADAM, a disintegrin and metalloprotease-containing transmembrane protein that is a member of the metzincin superfamily of proteases; UNC-71 is required non-cell autonomously for motor axon guidance and sex myoblast migration; UNC-71 does not appear to have an active metalloprotease domain, but functions with UNC-6/netrin and integrins INA-1/PAT-3 to provide guidance cues during axonal migration; UNC-71 is expressed in a restricted pattern in the excretory and excretory gland cells, some head neurons, the sphincter muscles, and hypodermal cells surrounding the vulva. WormBase CDS description: Disintegrin
                                              
Member of lists (Publications lists):
                                              McCarroll et al 2004  SFig1-4                                     
                                              conserved w/ Drosoph, Reinke et al 2004, fem1 enriched                             
                                              genes, Reinke et al 2004, wt vs glp-4 enriched genes,                              
                                              Reinke et al 2004, list of genes in cluster order,                                 
                                              Reinke et al 2004, oogenesis enriched genes, Reinke et                             
                                              al 2004, wt herm vs wt male enriched gen, Reinke et al                             
                                              2004, list of genes in cluster E                                                   

Y38A10A.5 crt-1 P W All gene names: crt-1; Y38A10A.5; Y38A10A.5.1; Y38A10A.5.2; 5G580; CE21562; NM_072174; WBGene00000802; WP:CE21562 WormBase description: calreticulin precursor
                                              
Member of lists (Publications lists):
                                              McCarroll et al 2004  SFig1-4                                     
                                              conserved w/ Drosoph, Reinke et al 2004, list of genes                             
                                              in cluster order, Reinke et al 2004, list of genes in                              
                                              cluster C, ViswanathanM et al 2005  S2 sir-2.1                                     
                                              regulated                                                                          

Y38F1A.5 cyd-1 P W All gene names: cyd-1; Y38F1A.5; Y38F1A.5.1; Y38F1A.5.2; Y38F1A.5.3; 2N281; CE21610; NM_064362; WBGene00000870; WP:CE21610 WormBase description: cyd-1 encodes a cyclin D homolog that is required for escape from G1 cycle arrest in postembryonic blast cells, affects movement and larval viability, and may physically interact with CDK-46 and CKI-1; expressed embryonically primarily in the head, ventral cord, tail, and is later expressed primarily in the seam cells and in the somatic gonad. WormBase CDS description: Cyclins
                                              
Member of lists (Publications lists):
                                              McCarroll et al 2004  SFig1-4                                     
                                              conserved w/ Drosoph, Reinke et al 2004, wt herm vs wt                             
                                              herm enriched gen, Reinke et al 2004, IVb male soma                                
                                              enriched genes                                                                     

Y39E4B.9 bre-2 P W All gene names: bre-2; Y39E4B.9; 3O222; CE36339; NM_067314; WBGene00000267; WP:CE36339 WormBase description: bre-2 is required for Cry5B toxicity.
                                              
Member of lists (Publications lists):
                                              Romagnolo et al 2002  Fig3b Unkown,                               
                                              ViswanathanM et al 2005  S2 sir-2.1 regulated                                      

Y39G10AL.3 cdk-7 P W All gene names: cdk-7; Y39G10AL.3; Y39G10AL.3.1; Y39G10AL.3.2; 1C850; CE30320; NM_058551; WBGene00000408; WP:CE30320 WormBase description: The cdk-7 gene encodes a cyclin-dependent kinase orthologous to human CDK7 (OMIM:601955) that is a component of the general transcription factor IIH (TFIIH) complex; CDK-7 is required during embryogenesis for mRNA transcription and phosphorylation of RNA polymerase II on serine 2 and serine 5, as well as for cell cycle progression, maintenance of ploidy, and completion of meiosis following fertilization.
                                              
Member of lists (Publications lists):
                                              McCarroll et al 2004  SFig5 conserved                             
                                              w/ yeast, McCarroll et al 2004  SFig1-4 conserved w/                               
                                              Drosoph                                                                            

Y39H10A.3 mtm-9 P W All gene names: cup-10; mtm-9; Y39H10A.3; Y39H10A.3a.1; Y39H10A.3a.2; 5E227; CE26073; CE36959; NM_071637; NM_182367; WBGene00003479; WP:CE26073; WP:CE36959 WormBase description: mtm-9 encodes a myotubularin-related protein that affects phosphoinositide 3-phosphate localization and mutation blocks endocytosis by the coelomocytes of C. elegans; MTM-9 is believed to function as part of a complex with MTM-6A and it is predominantly localized to the coelomocyte cytoplasm, with some localization to the membrane.
                                              
Member of lists (Publications lists):
                                              McCarroll et al 2004  SFig1-4                                     
                                              conserved w/ Drosoph, ViswanathanM et al 2005  S2                                  
                                              daf-16 Resveratrol                                                                 

Y40B1B.6 spr-5 P W All gene names: spr-5; Y40B1B.6; Y40B1B.6.1; Y40B1B.6.2; 1O41; CE20240; NM_060965; WBGene00005010; WP:CE20240
                                              
Member of lists (Publications lists):
                                              McCarroll et al 2004  SFig1-4                                     
                                              conserved w/ Drosoph, Reinke et al 2004, list of genes                             
                                              in cluster F, Reinke et al 2004, list of genes in                                  
                                              cluster order, ViswanathanM et al 2005  S2 sir-2.1                                 
                                              regulated                                                                          

Y41D4B.13 ced-2 P W All gene names: ced-2; Y41D4B.13; 4C365; CE28360; NM_067704; WBGene00000416; WP:CE28360 WormBase description: The ced-2 gene encodes a Src homology (SH) 2 and 3-containing adaptor protein, homologous to human CrkII, that is required for phagocytosis during programmed cell death and for migration of the distal tip cells of the somatic gonad; CED-2 functions in the engulfing cell during apoptosis and interacts with CED-5/DOCK180 to activate CED-10/Rac and promote formation of the polarized cell extensions associated with cell corpse engulfment.
                                              
Member of lists (Publications lists):
                                              McCarroll et al 2004  SFig1-4                                     
                                              conserved w/ Drosoph, ViswanathanM et al 2005  S2                                  
                                              sir-2.1 regulated                                                                  

Y41G9A.1 osm-5 P W All gene names: osm-5; Y41G9A.1; CE28361; NM_076110; WBGene00003885; WP:CE28361; XD609 WormBase description: The osm-5 gene encodes a homolog of the murine cystic kidney disease gene Tg737 that is required for the production of cilia in sensory neurons.
                                              
Member of lists (Publications lists):
                                              McCarroll et al 2004  SFig1-4                                     
                                              conserved w/ Drosoph                                                               

Y47H9C.4 ced-1 P W All gene names: ced-1; Y47H9C.4; 1M444; CE20264; CE30361; CE30362; NM_170927; WBGene00000415; WP:CE20264; WP:CE30361; WP:CE30362 WormBase description: The ced-1 gene encodes a transmembrane protein on phagocytic cells that is homologous to human CD91, a low density lipoprotein receptor paralog; the cytoplasmic tail of CED-1 contains two motifs important for engulfment. WormBase CDS description: EGF-like domain
Y48B6A.4 eat-2 P W All gene names: eat-2; Y48B6A.4; 2O460; CE22119; NM_064558; WBGene00001133; WP:CE22119 WormBase description: eat-2 encodes a ligand-gated ion channel subunit most closely related to the non-alpha-subunits of nicotinic acetylcholine receptors (nAChR); EAT-2 functions postsynaptically in pharyngeal muscle to regulate the rate of pharyngeal pumping; eat-2 is also required for normal life span and defecation; a functional EAT-2::GFP fusion protein localizes to two small dots near the junction of pharyngeal muscles pm4 and pm5, which is the site of the posterior-most MC motor neuron processes and the MC synapse; eat-2 genetically interacts with eat-18, which encodes a predicted novel transmembrane protein expressed in pharyngeal muscle and required for proper function of pharyngeal nicotonic receptors.
Y50D4C.4 sqv-6 P W All gene names: sqv-6; Y50D4C.4; 5B430; CE35919; NM_070958; WBGene00005024; WP:CE35919; sqv6 WormBase description: sqv-6 encodes a xylosyltransferase, active in cell culture, that is required for cytokinesis of one-cell embryos and for vulval morphogenesis; SQV-6 is predicted to begin the synthesis of glycosaminoglycans by adding xylose to their protein cores; the common requirement for SQV-6 in both cytokinesis and morphogenesis may be to promote filling an extracellular space with hygroscopic proteoglycans (either in the eggshell, or underneath the L4 cuticle), which in turn may cause the space to fill with fluid.
                                              
Member of lists (Publications lists):
                                              McCarroll et al 2004  SFig1-4                                     
                                              conserved w/ Drosoph, ViswanathanM et al 2005  S2                                  
                                              daf-16 Resveratrol                                                                 

Y50E8A.4 unc-61 P W All gene names: unc-61; Y50E8A.4; 5P212; CE24405; CE32023; NM_074237; NM_182356; WBGene00006795; WP:CE24405; WP:CE32023 WormBase description: unc-61, by alternative splicing, encodes two septin isoforms required (like the septin UNC-59) for normal axonal migration, distal tip cell migration, and postembryonic cytokinesis (at the cellular level) and for normal locomotion and formation of the postembryonic vulva, somatic gonad, and male tail (at the organismal level); both UNC-61A/B and UNC-59 are dispensable for embryonic cytokinesis and development, but are thought to be required for all postembryonic cytokinesis; UNC-61A/B and UNC-59 depend on each other for localization to the cytokinetic furrow.
                                              
Member of lists (Publications lists):
                                              Jones et al 2001  Non dauer genes                                 
                                              P<0.05, McCarroll et al 2004  SFig5 conserved w/ yeast,                            
                                              McCarroll et al 2004  SFig1-4 conserved w/ Drosoph,                                
                                              ViswanathanM et al 2005  S2 daf-16 Resveratrol                                     

Y53C12A.1 wee-1.3 P W All gene names: wee-1.3; spe-37; Y53C12A.1; 2K4; CE14884; NM_063694; WBGene00006940; WP:CE14884 WormBase description: serine/threonine kinase
                                              
Member of lists (Publications lists):
                                              McCarroll et al 2004  SFig5 conserved                             
                                              w/ yeast, McCarroll et al 2004  SFig1-4 conserved w/                               
                                              Drosoph, Reinke et al 2004, intrinsic, Reinke et al                                
                                              2004, Fig2b shared gemlines, Reinke et al 2004, wt vs                              
                                              glp-4 enriched genes, Reinke et al 2004, list of genes                             
                                              in cluster order, Reinke et al 2004, wt males vs glp4                              
                                              male enriched , Reinke et al 2004, list of genes in                                
                                              cluster E                                                                          

Y54E10A.4 fog-1 P W All gene names: cpb-4; fog-1; Y54E10A.4; Y54E10A.4a.1; Y54E10A.4a.2; 1D785; CE27479; CE27480; WBGene00001481; WP:CE27479; WP:CE27480 WormBase description: The fog-1 gene encodes a cytoplasmic polyadenylation element binding (CPEB) protein that is required for specification of the sperm fate.
Y54G11A.10 lin-7 P W All gene names: lin-7; Y54G11A.10; 2O634; CE28370; NM_064581; WBGene00002996; WP:CE28370 WormBase description: lin-7 encodes a protein that contains a PDZ domain and an L27 domain, two protein interaction domains that likely serve as organizational centers for large macromolecular complexes in polarized cells; LIN-7 is required for proper basolateral localization of the LET-23/EGF receptor in vulval epithelial cells, and along with LIN-2 and LIN-10, forms a protein complex that likely mediates this asymmetric localization with LIN-7 simultaneously binding to the C-terminus of LET-23 and an internal region of LIN-2; a LIN-7 translational reporter fusion indicates that LIN-7 is expressed at intestinal cell junctions; expression in vulval epithelial cells is detected only upon overexpression via heat shock, and reveals localization primarily at the lateral cell junctions of the vulval precursor cells P5.p and P6.p WormBase CDS description: PDZ domain (Also known as DHR or GLGF).
                                              
Member of lists (Publications lists):
                                              McCarroll et al 2004  SFig1-4                                     
                                              conserved w/ Drosoph, Reinke et al 2004, fem1 enriched                             
                                              genes, Reinke et al 2004, mixed oogenesis soma,                                    
                                              ViswanathanM et al 2005  S2 sir-2.1 regulated                                      

Y55D5A.5 daf-2 P W All gene names: daf-2; Y55D5A.5; Y55D5A_392.A; 3E86; CE27499; NM_065249; WBGene00000898; WP:CE27499 WormBase description: daf-2 encodes a predicted receptor tyrosine kinase that is the C. elegans insulin/IGF receptor ortholog; DAF-2 activity is required for a number of processes in C. elegans, including embryonic and larval development, formation of the developmentally arrested dauer larval stage, adult longevity, reproduction, fat storage, and response to exogenous stressors such as high temperature or bacterial infection; DAF-2 signals through a conserved PI 3-kinase pathway to negatively regulate the activity of DAF-16, a Forkhead-related transcription factor, by inducing its phosphorylation and nuclear exclusion; amongst the 38 predicted insulin-like molecules in C. elegans, genetic and microarray analyses suggest that at least DAF-28, INS-1, and INS-7 are likely DAF-2 ligands; genetic mosaic and tissue-specific promoter studies indicate that daf-2 can function cell nonautonomously and within multiple cell types to influence dauer formation and adult lifespan, likely by regulating the production of secondary signals that coordinate growth and longevity throughout the animal.
                                              
Member of lists (Publications lists):
                                              Jones et al 2001  T2 lifespan and                                 
                                              Dauer, McCarroll et al 2004  SFig1-4 conserved w/                                  
                                              Drosoph, Reinke et al 2004, intrinsic, Reinke et al                                
                                              2004, wt vs glp-4 enriched genes, Reinke et al 2004,                               
                                              list of genes in cluster order, Reinke et al 2004, list                            
                                              of genes in cluster E, Roy et al 2002  S3 muscle genes                             

Y60A3A.12 chk-2 P W All gene names: Ce-cds-1; Ce-chk-2; cds-1; chk-2; Y60A3A.12; 5U380; CE27297; WBGene00000499; WP:CE27297 WormBase description: chk-2 encodes a member of the Cds1/Chk2 checkpoint kinase family, orthologous to human CHK2 (OMIM:604373, mutated in Li-Fraumeni syndrome), that affects pairing between homologous chromosomes during early meiotic prophase, and might function to couple premeiotic S phase with early prophase; CHK-2 is expressed in the germ line.
                                              
Member of lists (Publications lists):
                                              McCarroll et al 2004  SFig1-4                                     
                                              conserved w/ Drosoph                                                               

Y66D12A.20 spe-6 P W All gene names: spe-6; Y66D12A.20; 3M597; CE28799; NM_067081; WBGene00004960; WP:CE28799 WormBase description: spe-6 encodes a predicted protein-serine threonine kinase in the casein kinase 1 family that is required for spermatid activation, and for progression through late prophase of meiosis I, and is specifically required for the assembly of MSP (major sperm protein) in the fibrous bodies of spermatocytes; bypasses the requirement for spe-27, spe-8, spe-12, and spe-29 with respect to spermatid activation.
Y67H2A.8 fat-1 P W All gene names: fat-1; Y67H2A.8; Y67H2A.8.1; Y67H2A.8.2; 4O83; CE22790; WBGene00001393; WP:CE22790 WormBase description: The fat-1 gene encodes an omega-3 fatty acyl desaturase that acts on substrates of 16-20 carbons with a preference for omega-6 fatty acids; FAT-1 dehydrogenates its substrates 3 carbons from the methyl terminus; FAT-1 is required in vivo for n3 polyunsaturated fatty acid (PUFA) synthesis. WormBase CDS description: fatty acid desaturase
Y69A2AR.2 ric-8 P W All gene names: ric-8; Y69A2AR.2; 4D413; CE27516; CE33952; NM_067838; WBGene00004367; WP:CE27516; WP:CE33952 WormBase description: ric-8 encodes a receptor-independent G alpha guanine nucleotide exchange factor (GEF); ric-8 activity is required for regulating heterotrimeric G protein signaling pathways that control asymmetric cell division in the embryo as well as synaptic transmission in the nervous system; in the 1-cell embryo, RIC-8 functions as a GEF for GOA-1 thereby regulating spindle morphology, position, and consequently, the first asymmetric cell division; in the nervous system, ric-8 interacts with the goa-1/egl-30 pathways to regulate neurotransmitter secretion and effect normal egg laying, movement, and body flexion; in vitro, RIC-8 preferentially binds GOA-1-GDP and increases the rate of GOA-1 GTP binding; in the early embryo, RIC-8 localizes to the cellular cortex, junctions between cells, asters of the mitotic spindle, the central spindle (kinetochore microtubules), the nuclear envelope, and chromatin; RIC-8's localization to the cortex and asters mirrors that of GOA-1, while localization to the cortex and central spindle is similar to that of the GOA-1 regulators GPR-1/2, whose subcellular localization is RIC-8-dependent; in later stage animals, RIC-8 is seen in head and tail ganglia, amphid processes, and the ventral nerve cord, as well as in larval nonneuronal cells, such as germline nuclei, where it localizes near the nuclear membrane.
                                              
Member of lists (Publications lists):
                                              McCarroll et al 2004  SFig1-4                                     
                                              conserved w/ Drosoph, ViswanathanM et al 2005  S2                                  
                                              daf-16 Resveratrol                                                                 

Y71F9AR.1 bam-2 P W All gene names: bam-2; Y71F9AR.1; 1D518; CE33243; NM_058680; WBGene00000237; WP:CE33243
                                              
Member of lists (Publications lists):
                                              ViswanathanM et al 2005  S2 sir-2.1                               
                                              regulated                                                                          

Y73B6A.5 lin-45 P W All gene names: lin-45; raf-1; Y73B6A.5; Y73B6A.5a.1; Y73B6A.5a.2; 4H508; CE25585; CE31742; NM_171367; WBGene00003030; WP:CE25585; WP:CE31742 WormBase description: The lin-45 gene encodes an ortholog of the vertebrate protein RAF which is required for larval viability, fertility and the induction of vulval cell fates.
                                              
Member of lists (Publications lists):
                                              McCarroll et al 2004  SFig1-4                                     
                                              conserved w/ Drosoph                                                               

Y73E7A.7 bre-4 P W All gene names: bre-4; Y73E7A.7; 1C94; CE26412; NM_058471; WBGene00000269; WP:CE26412 WormBase description: bre-4 encodes a predicted galactosyltransferase that is required for the toxicity of Bacillus thuringiensis Cry5B.
                                              
Member of lists (Publications lists):
                                              McCarroll et al 2004  SFig1-4                                     
                                              conserved w/ Drosoph                                                               

Y79H2A.11 zyg-8 P W All gene names: apo-1; zyg-8; Y79H2A.11; Y79H2A.G; 3N161; CE31133; NM_067170; WBGene00006993; WP:CE31133 WormBase description: The zyg-8 gene encodes a protein with a doublecortin-like domain and a protein kinase domain; mutations of zyg-8 impair mitosis at the one-cell embryonic stage, which is normally asymmetrical, but which fails to show proper asymmetry in zyg-8 mutant embryos.
                                              
Member of lists (Publications lists):
                                              McCarroll et al 2004  SFig1-4                                     
                                              conserved w/ Drosoph, Romagnolo et al 2002  Fig3b                                  
                                              Unkown                                                                             

Y95B8A.5 gpa-16 P W All gene names: gpa-16; spn-1; Y95B8A.5; 1B377; CE24692; NM_058389; WBGene00001678; WP:CE24692 WormBase description: gpa-16 (also known as spn-1) encodes a member of the G protein alpha subunit family of heterotrimeric GTPases that affects spindle position and orientation in embryos; it is expressed in AVM, PDE, PLM, BDU, PVC, and RIP, and weakly expressed in the pharynx, body-wall muscle, and vulval muscle. WormBase CDS description: G-protein
                                              
Member of lists (Publications lists):
                                              McCarroll et al 2004  SFig1-4                                     
                                              conserved w/ Drosoph                                                               

ZC302.1 mre-11 P W All gene names: mre-11; ZC302.1; ZC302.1.1; ZC302.1.2; 5L214; CE37459; NM_073335; WBGene00003405; WP:CE37459 WormBase description: mre-11 encodes a protein orthologous to S. cerevisiae MRE11 and to human MRE11A (OMIM:600814, mutated in ataxia-telangiectasia-like disorder); MRE-11 is required for meiotic recombination and DNA repair in C. elegans, for multigenerational persistence of the germline, and (in conjunction with CHK-2 and SPO-11) for the localization of RAD-51 to foci in late zygotene/early pachytene nuclei. WormBase CDS description: Human MRE11 protein like
                                              
Member of lists (Publications lists):
                                              McCarroll et al 2004  SFig5 conserved                             
                                              w/ yeast, McCarroll et al 2004  SFig1-4 conserved w/                               
                                              Drosoph, Reinke et al 2004, list of genes in cluster F,                            
                                              Reinke et al 2004, fem1 enriched genes, Reinke et al                               
                                              2004, list of genes in cluster order, Reinke et al                                 
                                              2004, oogenesis enriched genes, Reinke et al 2004, wt                              
                                              vs glp-4 enriched genes, Reinke et al 2004, wt herm vs                             
                                              wt male enriched gen, ViswanathanM et al 2005  S2                                  
                                              daf-16 Resveratrol, ViswanathanM et al 2005  S2 sir-2.1                            
                                              regulated                                                                          

ZC308.1 gld-2 P W All gene names: gld-2; let-606; ZC308.1; 1G961; CE15159; CE32766; CE33255; CE33256; NM_059441; WBGene00001596; WP:CE15159; WP:CE32766; WP:CE33255; WP:CE33256 WormBase description: gld-2 encodes the catalytic subunit of a cytoplasmic poly(A) polymerase (PAP) associated with P granules in early embryos, which encodes the central catalytic domain but lacks the normal RNA-binding (RRM) domain of eukaryotic PAPs; GLD-2 regulates the switch from mitosis to meiosis in the germline, is necessary for formation of functional sperm or oocytes, requires activation by GLD-3 for PAP activity in vitro, and contains a glutamine/asparagine-rich domain perhaps involved in epigenetic gene control.
                                              
Member of lists (Publications lists):
                                              McCarroll et al 2004  SFig1-4                                     
                                              conserved w/ Drosoph, Reinke et al 2004, intrinsic,                                
                                              Reinke et al 2004, list of genes in cluster F, Reinke                              
                                              et al 2004, wt vs glp-4 enriched genes, Reinke et al                               
                                              2004, list of genes in cluster order                                               

ZC404.3 spe-39 P W All gene names: spe-39; ZC404.3; 5H267; CE07594; CE29620; NM_072317; NM_072318; WBGene00004975; WP:CE07594; WP:CE29620
                                              
Member of lists (Publications lists):
                                              Reinke et al 2004, intrinsic, Reinke                              
                                              et al 2004, list of genes in cluster F, Reinke et al                               
                                              2004, wt vs glp-4 enriched genes, Reinke et al 2004,                               
                                              list of genes in cluster order, Reinke et al 2004, wt                              
                                              herm vs wt male enriched gen, ViswanathanM et al 2005                              
                                              S2 sir-2.1 regulated                                                               

ZC404.8 spn-4 P W All gene names: gei-20; pip-1; spn-4; ZC404.8; 5H264; CE07598; NM_072316; WBGene00004984; WP:CE07598 WormBase description: spn-4 encodes a protein containing an RNP-type RNA-binding domain; SPN-4 is required for rotation, but not polarization, of the mitotic spindle in the P1 blastomere of the two-cell stage embryo; SPN-4 is also required for mesectoderm and mesendoderm formation in conjunction with proper localization of maternal cell-fate determinants such as SKN-1; in addition, SPN-4 binds the glp-1 3' UTR and is necessary for glp-1 mRNA translation in the anterior blastomeres of the early embryo; conversely, SPN-4 binds and suppresses translation of pal-1 and skn-1 mRNAs in anterior blastomeres; in vitro, SPN-4 interacts with POS-1, a CCCH-type zinc finger protein that negatively regulates glp-1 mRNA translation in posterior blastomeres; SPN-4 is a P granule component, but is also detected in oocytes, the AB and P1 blastomeres at the two-cell stage, and in all four blastomeres at the four-cell stage, with higher levels in EMS and P2. WormBase CDS description: RNA-binding protein
                                              
Member of lists (Publications lists):
                                              Reinke et al 2004, fem1 enriched                                  
                                              genes, Reinke et al 2004, Fig2b shared gemlines, Reinke                            
                                              et al 2004, list of genes in cluster order, Reinke et                              
                                              al 2004, oogenesis enriched genes, Reinke et al 2004,                              
                                              wt vs glp-4 enriched genes, Reinke et al 2004, wt males                            
                                              vs glp4 male enriched , Reinke et al 2004, wt herm vs                              
                                              wt male enriched gen, Reinke et al 2004, list of genes                             
                                              in cluster E, ViswanathanM et al 2005  S2 sir-2.1                                  
                                              regulated                                                                          

ZC416.8 unc-17 P W All gene names: cha-1; unc-17; ZC416.8; 4E380; CE17307; CE17308; WBGene00000481; WBGene00006756; WP:CE17307; WP:CE17308 WormBase description: unc-17 encodes a synaptic vesicle acetylcholine transporter (VAChT) highly conserved amongst metazoans including Drosophila and humans (OMIM:600336); UNC-17 is essential for embryonic development, and is required in cholinergic neurons for loading acetylcholine into synaptic vesicles to which UNC-17 is localized; UNC-17 expression may be regulated indirectly by the UNC-4/UNC-37 transcriptional repressor complex, as UNC-17 expression is greatly reduced in unc-4 and unc-37 mutant backgrounds. WormBase CDS description: putative acetylcholine transporter
                                              
Member of lists (Publications lists):
                                              Reinke et al 2004, wt herm vs wt herm                             
                                              enriched gen, Reinke et al 2004, IVb male soma enriched                            
                                              genes, ViswanathanM et al 2005  S2 sir-2.1 regulated                               

ZC513.6 oma-2 P W All gene names: dao-7; moe-2; oma-2; ZC513.6; 5I511; CE07613; NM_072668; WBGene00003865; WP:CE07613 WormBase description: The oma-2 gene encodes a zinc finger protein of the TIS11 finger type that is paralogous to OMA-1; while either oma-1 or oma-2 individually have no obvious mutant phenotype, a normal copy of at least one of these genes is required for oocyte maturation. WormBase CDS description: zinc finger protein
                                              
Member of lists (Publications lists):
                                              Reinke et al 2004, fem1 enriched                                  
                                              genes, Reinke et al 2004, wt vs glp-4 enriched genes,                              
                                              Reinke et al 2004, list of genes in cluster order,                                 
                                              Reinke et al 2004, oogenesis enriched genes, Reinke et                             
                                              al 2004, wt herm vs wt male enriched gen, Reinke et al                             
                                              2004, GO categories, Reinke et al 2004, list of genes                              
                                              in cluster E, ViswanathanM et al 2005  S2 sir-2.1                                  
                                              regulated                                                                          

ZK1067.1 let-23 P W All gene names: kin-7; let-23; ZK1067.1; 2J497; CE03840; NM_063561; WBGene00002299; WP:CE03840 WormBase description: The let-23 gene encodes a member of the EGF-receptor family of transmembrane tyrosine kinases that affects viability, inductive signaling during development of the vulva, male spicule formation, posterior development of the epidermis, and ovulation; it is genetically upstream of the let-60/RAS pathway with respect to viability and vulval development, is upstream of the IP3 pathway with respect to fertility, and is expressed in vulval precursor cells. WormBase CDS description: tyrosine-protein kinase (Epidermal growth factor receptor subfamily)
                                              
Member of lists (Publications lists):
                                              McCarroll et al 2004  SFig1-4                                     
                                              conserved w/ Drosoph, ViswanathanM et al 2005  S2                                  
                                              sir-2.1 regulated                                                                  

ZK1098.10 unc-16 P W All gene names: egl-39; unc-16; ZK1098.10; 3K645; CE00363; CE31846; NM_171221; WBGene00006755; WP:CE00363; WP:CE31846 WormBase description: unc-16 encodes a homolog of murine JIP3/JSAP and Drosophila SUNDAY DRIVER that is involved in vesicle transport, and that affects egg laying, locomotion, and defecation and physically interacts with JNK and JNK kinases; UNC-16 is expressed in neurons of the ventral cord, retrovesicular and preanal ganglia, the nerve ring, intestinal cells, seam and hypodermal cells, body wall and head muscle, and pharynx.
                                              
Member of lists (Publications lists):
                                              McCarroll et al 2004  SFig1-4                                     
                                              conserved w/ Drosoph, ViswanathanM et al 2005  S2                                  
                                              sir-2.1 regulated, ViswanathanM et al 2005  S2 daf-16                              
                                              Resveratrol                                                                        

ZK1151.1 vab-10 P W All gene names: vab-10; ZK1151.1; 1M340; CE35150; CE35151; CE35152; CE36460; CE36461; CE36462; CE36463; CE39998; WBGene00006876; WP:CE35150; WP:CE35151; WP:CE35152; WP:CE36460; WP:CE36461; WP:CE36462; WP:CE36463; WP:CE39998 WormBase description: vab-10 encodes, by alternative splicing, two spectraplakins (VAB-10A and VAB-10B) that are jointly required for mechanical resilience of the epidermis under strain by the contraction of actin microfilaments mechanically linked to fibrous organelles (FOs); VAB-10A/B are, accordingly, required for elongation during embryonic morphogenesis; VAB-10A has C-terminal plectin repeats while VAB-10B has spectrin repeats; VAB-10A is required to keep the epidermis and extracellular matrix attached via FOs, while VAB-10B is required to keep the apical and basal epidermal plasma membranes connected during morphogenesis; vab-10a and vab-10b mutations complement one another; vab-10 is orthologous to human BPAG1 (dystonin or MACF2, OMIM:113810, encoding an autoantigen of bullous pemphigoid blistering disease) and dJ562N20.1 (MACF1), and to Drosophila SHORT STOP.
                                              
Member of lists (Publications lists):
                                              Reinke et al 2004, intrinsic, Reinke                              
                                              et al 2004, wt vs glp-4 enriched genes, Reinke et al                               
                                              2004, list of genes in cluster order, Reinke et al                                 
                                              2004, list of genes in cluster C, ViswanathanM et al                               
                                              2005  S2 sir-2.1 regulated                                                         

ZK1307.6 fzr-1 P W All gene names: fzr-1; ZK1307.6; 2J930; CE01695; NM_063674; WBGene00001510; WP:CE01695 WormBase description: fzr-1 encodes a WD repeat-containing protein homologous to Cdh1/Hct1/FZR (OMIM:603619), a regulatory subunit of the anaphase-promoting complex/cyclosome (APC/C) required for anaphase initiation and exit from mitosis; FZR-1 is required for fertility, and also functions redundantly with lin-35/Rb to for normal embryogensis and control of postembryonic cell proliferation; FZR-1 probably regulates the levels of G1 cyclins, degradation of which is critical for G1 arrest. WormBase CDS description: CDC20 protein
                                              
Member of lists (Publications lists):
                                              McCarroll et al 2004  SFig5 conserved                             
                                              w/ yeast, McCarroll et al 2004  SFig1-4 conserved w/                               
                                              Drosoph                                                                            

ZK177.6 fzy-1 P W All gene names: fzy-1; ZK177.6; 2F793; CE26338; NM_062650; WBGene00001511; WP:CE26338 WormBase description: CDC20
                                              
Member of lists (Publications lists):
                                              Reinke et al 2004, Fig2b shared                                   
                                              gemlines, Reinke et al 2004, list of genes in cluster                              
                                              order, Reinke et al 2004, intrinsic, Reinke et al 2004,                            
                                              wt vs glp-4 enriched genes, Reinke et al 2004, wt males                            
                                              vs glp4 male enriched , Reinke et al 2004, wt herm vs                              
                                              wt male enriched gen, Reinke et al 2004, list of genes                             
                                              in cluster E, ViswanathanM et al 2005  S2 sir-2.1                                  
                                              regulated                                                                          

ZK328.1 cyk-3 P W All gene names: cyk-3; uch-1; ZK328.1; 3H113; CE30061; CE30062; NM_065910; WBGene00000874; WP:CE30061; WP:CE30062 WormBase description: cyk-3 encodes a functional ubiquitin C-terminal hydrolase required for embryonic viability and for cellular osmotic regulation; osmotic regulation defects in mutants contribute at least partially to cytokinesis defects in mutant embryos.
                                              
Member of lists (Publications lists):
                                              Reinke et al 2004, wt herm vs wt male                             
                                              enriched gen, ViswanathanM et al 2005  S2 sir-2.1                                  
                                              regulated                                                                          

ZK524.3 lrs-2 P W All gene names: lrs-2; ZK524.3; 1I34; CE35160; CE35161; WBGene00003074; WP:CE35160; WP:CE35161 WormBase description: leucyl-tRNA synthetase (mitochondrial)
                                              
Member of lists (Publications lists):
                                              McCarroll et al 2004  SFig5 conserved                             
                                              w/ yeast, McCarroll et al 2004  SFig1-4 conserved w/                               
                                              Drosoph, Wang et al 2003  S5 genes common to feeding                               
                                              ANOVA, Wang et al 2003  S3  genes pass one-way ANOVA                               

ZK546.1 zyg-12 P W All gene names: ber-1; zyg-12; ZK546.1; ZK546.1d.1; ZK546.1d.2; CE28524; CE32088; CE36518; CE39461; WBGene00006997; WP:CE28524; WP:CE32088; WP:CE36518; WP:CE39461 WormBase description: zyg-12 encodes three coiled-coil domain-containing proteins that belong to the Hook protein family, members of which likely act as linker proteins that connect membrane compartments with the microtubule cytoskeleton; during embryonic development, zyg-12 activity is essential and is required continuously for nuclear-centrosome attachment and proper nuclear positioning within cells; in addition, zyg-12 is required after fertilization for proper pronuclear migration; two predicted transmembrane isoforms of ZYG-12 localize to the nuclear envelope and to centrosomes, while a third ZYG-12 isoform lacking a transmembrane domain localizes only to centrosomes; ZYG-12 nuclear envelope localization is seen in the syncytial gonad, oocytes, and early embryonic nuclei and requires SUN-1 function; in turn, ZYG-12 is required for nuclear envelope localization of DHC-1/dynein heavy chain, LIS-1, and ARP-1; ZYG-12 localization to centrosomes requires microtubules; in yeast two-hybrid assays, ZYG-12 interacts with itself and with the DLI-1/dynein light intermediate chain.
                                              
Member of lists (Publications lists):
                                              Reinke et al 2004, list of genes in                               
                                              cluster F, Reinke et al 2004, list of genes in cluster                             
                                              order, ViswanathanM et al 2005  S2 sir-2.1 regulated                               

ZK632.13 lin-52 P W All gene names: lin-52; ZK632.13; 3K914; CE01711; NM_066778; WBGene00003035; WP:CE01711 WormBase description: lin-52 encodes a novel protein that is most closely related to the Drosophila melanogaster CG15929 protein and the human protein XP_040376; lin-52 is a class B synthetic multivulva (synMuv) gene that appears to function with lin-35/Rb to negatively regulate vulval development; in addition, lin-52 is also required for germline and larval development.
                                              
Member of lists (Publications lists):
                                              ViswanathanM et al 2005  S2 sir-2.1                               
                                              regulated, ViswanathanM et al 2005  S2 daf-16                                      
                                              Resveratrol                                                                        

ZK637.7 lin-9 P W All gene names: lin-9; ZK637.7; 3J990; CE28194; CE28195; WBGene00002998; WP:CE28194; WP:CE28195 WormBase description: lin-9 encodes two novel proteins that are conserved amongst C. elegans, Drosophila, plants, and vertebrates; lin-9 activity is required redundantly with activity of the synMuv A genes, such as lin-8, for negative regulation of the RTK/Ras-mediated signal transduction pathway that controls vulval development; in addition, lin-9 activity is required non-redundantly for hermaphrodite gonadal sheath cell development (and thus, reproduction), as well as for development of the male reproductive system including the male sensory rays and spicules.
                                              
Member of lists (Publications lists):
                                              McCarroll et al 2004  SFig1-4                                     
                                              conserved w/ Drosoph, Reinke et al 2004, list of genes                             
                                              in cluster F, Reinke et al 2004, list of genes in                                  
                                              cluster order, Reinke et al 2004, intrinsic, Reinke et                             
                                              al 2004, wt vs glp-4 enriched genes, Reinke et al 2004,                            
                                              wt herm vs wt male enriched gen, ViswanathanM et al                                
                                              2005  S2 daf-16 Resveratrol, ViswanathanM et al 2005                               
                                              S2 sir-2.1 regulated                                                               

ZK721.2 unc-27 P W All gene names: tni-2; unc-27; unc-99; ZK721.2; CE40008; NM_077087; WBGene00006764; WP:CE40008; XJ409 WormBase description: troponin I
                                              
Member of lists (Publications lists):
                                              Golden et al 2004, N2 vs daf-2                                    
                                              different genes at , McCarroll et al 2004  SFig1-4                                 
                                              conserved w/ Drosoph, Reinke et al 2004, list of genes                             
                                              in cluster order, Reinke et al 2004, list of genes in                              
                                              cluster C                                                                          

ZK836.1 lon-3 P W All gene names: lon-3; ZK836.1; 5M678; CE15415; WBGene00003057; WP:CE15415 WormBase description: collagen
                                              
Member of lists (Publications lists):
                                              Jones et al 2001  Non dauer genes                                 
                                              P<0.05, ReichertK et al 2005  T2 xenobiotic induced                                
                                              Collag, Wang et al 2003  S3  genes pass one-way ANOVA,                             
                                              Wang et al 2003  S4 LateList, Wang et al 2003  S4 genes                            
                                              pass two-wayANOVA P0                                                               

ZK973.6 anc-1 P W All gene names: anc-1; ZK973.6; 1E925; CE33588; NM_058952; WBGene00000140; WP:CE33588 WormBase description: anc-1 encodes a 8546-residue protein, orthologous of Drosophila Msp-300 and mammalian Syne proteins, which may extend more than 0.5 micrometers in vivo; ANC-1 has coiled regions, a nuclear envelope localization domain (the KASH domain) and an actin-binding domain; ANC-1 affects the positioning of nuclei and mitochondria within the cytoskeleton; ANC-1 is expressed in the cytoplasm, but localized to the nuclear periphery in an UNC-84-dependent manner.
                                              
Member of lists (Publications lists):
                                              Reinke et al 2004, list of genes in                               
                                              cluster order, Reinke et al 2004, list of genes in                                 
                                              cluster B, Romagnolo et al 2002  Fig3b Unkown