Hill et al 2000, developmentally modulated cluster, 84 genes

Gene list file name:Hill2000_T1_cluster2-3.txt
Type of gene identifier:Affymetrix custom chip
Description:Hill et al 2000, Supplymental Dataset, developmentally modulated genes cluster(2,3)  
Organism:Caenorhabditis elegans (nematode)
Gene list type:Experimental

Gene name             Source Gene ID          Annotation                                                  Date       Added by    

AFF_C23H3.4 Aff_C23H3.4 P W
AFF_F23H12.1 Aff_F23H12.1 P W
AFF_F53F10.3 Aff_F53F10.3 P W
AFF_T15B7.9 Aff_T15B7.9 P W
AFF_Y34D9A_150.D Aff_Y34D9A_150.D P W
B0280.3 Aff_B0280.3 P W All gene names: B0280.3; B0280.3.1; B0280.3.2; 3I213; CE00733; WBGene00015101; WP:CE00733
                                              
Member of lists (Publications lists):
                                              McCarroll et al 2004  SFig5 conserved                             
                                              w/ yeast, McCarroll et al 2004  SFig1-4 conserved w/                               
                                              Drosoph, ViswanathanM et al 2005  S2 sir-2.1 regulated                             

C05D11.11 Aff_C05D11.11 P W All gene names: mel-32; C05D11.11; C05D11.11a.1; C05D11.11a.2; C05D11.11a.3; C05D11.11b.1; C05D11.11b.2; 3H530; CE01130; CE29661; NM_171169; NM_171170; WBGene00003214; WP:CE01130; WP:CE29661
                                              
Member of lists (Publications lists):
                                              McCarroll et al 2004  SFig5 conserved                             
                                              w/ yeast, McCarroll et al 2004  SFig1-4 conserved w/                               
                                              Drosoph, ViswanathanM et al 2005  S2 sir-2.1 regulated,                            
                                              Wang et al 2003  S4 Climbing, Wang et al 2003  S3                                  
                                              genes pass one-way ANOVA, Wang et al 2003  S4 genes                                
                                              pass two-wayANOVA P0                                                               

C05E4.9 Aff_C05E4.9 P W All gene names: gei-7; C05E4.9; C05E4.9a.1; C05E4.9a.2; C05E4.9a.3; C05E4.9b.1; C05E4.9b.2; 5B204; CE23521; CE32565; NM_070905; WBGene00001564; WP:CE23521; WP:CE32565 WormBase description: gei-7 encodes a predicted isocitrate lyase/malate synthase, an enzyme known to function in the glyoxylate cycle; GEI-7 was identified in a screen for proteins that interact with GEX-3, a homolog of human HEM-2 which is required for embryonic development; GEI-7 is required for embryonic morphogenesis and appears to act downstream of DAF-16 to influence lifespan.
                                              
Member of lists (Publications lists):
                                              McCarroll et al 2004  SFig5 conserved                             
                                              w/ yeast, Murphy et al 2003  Fig2 Class1 elongate                                  
                                              lifespan, ViswanathanM et al 2005  S2 sir-2.1 regulated                            

C06H5.6 Aff_C06H5.6 P W All gene names: C06H5.6; 5S360; CE31876; WBGene00007394; WP:CE31876
                                              
Member of lists (Publications lists):
                                              ViswanathanM et al 2005  S2 sir-2.1                               
                                              regulated                                                                          

C08E8.4 Aff_C08E8.4 P W All gene names: C08E8.4; 5S845; CE17378; WBGene00007440; WP:CE17378
                                              
Member of lists (Publications lists):
                                              Kwon et al 2004  T1 late-repression                               
                                              Ethanol-respon, Murphy et al 2003  Fig2 Class1 elongate                            
                                              lifespan                                                                           

C09B8.6 Aff_C09B8.6 P W All gene names: hsp-25; C09B8.6; C09B8.6c.1; C09B8.6c.2; C09B8.6c.3; C09B8.6c.4; CE02466; CE33558; CE37953; WBGene00002023; WP:CE02466; WP:CE33558; WP:CE37953; XG654 WormBase description: Small heat shock protein
                                              
Member of lists (Publications lists):
                                              McCarroll et al 2004  SFig1-4                                     
                                              conserved w/ Drosoph, ViswanathanM et al 2005  S2                                  
                                              sir-2.1 regulated                                                                  

C12C8.2 Aff_C12C8.2 P W All gene names: C12C8.2; 1J905; CE36100; WBGene00007533; WP:CE36100 WormBase description: L-methionine-alpha-deamino-gamma-mercaptomethane lyase
                                              
Member of lists (Publications lists):
                                              Murphy et al 2003  Fig2 Class2 shorten                            
                                              lifespan, ViswanathanM et al 2005  S2 sir-2.1                                      
                                              regulated, Wang et al 2003  S4 Early genes, Wang et al                             
                                              2003  S3  genes pass one-way ANOVA, Wang et al 2003  S4                            
                                              genes pass two-wayANOVA P0                                                         

C15C7.5 Aff_C15C7.5 P W All gene names: C15C7.5; CE03991; WBGene00015791; WP:CE03991; XD770
                                              
Member of lists (Publications lists):
                                              Reinke et al 2004, list of genes in                               
                                              cluster order, Reinke et al 2004, list of genes in                                 
                                              cluster C, ViswanathanM et al 2005  S2 sir-2.1                                     
                                              regulated, ViswanathanM et al 2005  S2 daf-16                                      
                                              Resveratrol, Wang et al 2003  S4 TransientList, Wang et                            
                                              al 2003  S3  genes pass one-way ANOVA, Wang et al 2003                             
                                              S4 genes pass two-wayANOVA P0                                                      

C17G1.3 Aff_C17G1.3 P W All gene names: ugt-23; C17G1.3; CE08282; WBGene00007650; WP:CE08282; XK542 WormBase description: UDP-glucosyltransferase
                                              
Member of lists (Publications lists):
                                              Reinke et al 2004, list of genes in                               
                                              cluster order, Reinke et al 2004, list of genes in                                 
                                              cluster C, Reinke et al 2004, GO categories, Reinke et                             
                                              al 2004, herm soma enriched genes, Wang et al 2003  S3                             
                                              genes pass one-way ANOVA, Wang et al 2003  S4 Dauer                                
                                              Enriched, Wang et al 2003  S4 genes pass two-wayANOVA                              
                                              P0                                                                                 

C27H6.4 Aff_C27H6.4 P W All gene names: C27H6.4; 5K464; CE08428; CE31322; WBGene00007786; WP:CE08428; WP:CE31322
C29G2.6 Aff_C29G2.6 P W All gene names: C29G2.6; 5D58; CE08467; WBGene00016234; WP:CE08467
                                              
Member of lists (Publications lists):
                                              Romagnolo et al 2002  Fig3b Unkown,                               
                                              Wang et al 2003  S3  genes pass one-way ANOVA, Wang et                             
                                              al 2003  S4 Dauer Enriched, Wang et al 2003  S4 genes                              
                                              pass two-wayANOVA P0                                                               

C34C12.7 Aff_C34C12.7 P W All gene names: C34C12.7; 3E574; CE01515; WBGene00007926; WP:CE01515
                                              
Member of lists (Publications lists):
                                              Reinke et al 2004, list of genes in                               
                                              cluster order, Reinke et al 2004, list of genes in                                 
                                              cluster B, ViswanathanM et al 2005  S2 daf-16                                      
                                              Resveratrol                                                                        

C34F11.3 Aff_C34F11.3 P W All gene names: C34F11.3; C34F11.3a.1; C34F11.3a.2; 2F499; CE33034; CE33035; CE39332; WBGene00016415; WP:CE33034; WP:CE33035; WP:CE39332 WormBase description: AMP deaminase
                                              
Member of lists (Publications lists):
                                              Reinke et al 2004, mixed sperm soma,                              
                                              Reinke et al 2004, fem3 enriched genes, ViswanathanM et                            
                                              al 2005  S2 sir-2.1 regulated                                                      

C36A4.2 Aff_C36A4.2 P W All gene names: cyp-25A2; C36A4.2; 3E925; CE37617; NM_065375; WBGene00007964; WP:CE37617 WormBase description: cytochrome P450
                                              
Member of lists (Publications lists):
                                              Custodia et al 2001  T2 Cytochrome                                
                                              P450, McCarroll et al 2004  SFig1-4 conserved w/                                   
                                              Drosoph, Menzel et al 2001  T3 CYP genes, Reinke et al                             
                                              2004, herm soma enriched genes, Reinke et al 2004, GO                              
                                              categories, ViswanathanM et al 2005  S2 sir-2.1                                    
                                              regulated, Wang et al 2003  S5 genes common to feeding                             
                                              ANOVA, Wang et al 2003  S3  genes pass one-way ANOVA                               

C52G5.2 Aff_C52G5.2 P W All gene names: C52G5.2; CE03086; WBGene00008260; WP:CE03086; XN463
                                              
Member of lists (Publications lists):
                                              Jones et al 2001  Non dauer genes                                 
                                              P<0.05, Reinke et al 2004, list of genes in cluster                                
                                              order, Reinke et al 2004, list of genes in cluster C,                              
                                              Reinke et al 2004, wt herm vs wt herm enriched gen,                                
                                              Wang et al 2003  S3  genes pass one-way ANOVA, Wang et                             
                                              al 2003  S4 LateList, Wang et al 2003  S4 genes pass                               
                                              two-wayANOVA P0                                                                    

D1005.1 Aff_D1005.1 P W All gene names: D1005.1; CE06997; WBGene00016995; WP:CE06997; XC101 WormBase description: This gene encodes a protein predicted by Eisenberg and coworkers, with 52% accuracy, to be mitochondrial. WormBase CDS description: ATP citrate lyase
D1009.1 Aff_D1009.1 P W All gene names: D1009.1; CE04285; CE27891; WBGene00017012; WP:CE04285; WP:CE27891; XJ557 WormBase description: fatty acid transporter protein
                                              
Member of lists (Publications lists):
                                              McCarroll et al 2004  SFig5 conserved                             
                                              w/ yeast, McCarroll et al 2004  SFig1-4 conserved w/                               
                                              Drosoph, ViswanathanM et al 2005  S2 sir-2.1 regulated,                            
                                              Wang et al 2003  S3  genes pass one-way ANOVA, Wang et                             
                                              al 2003  S4 Dauer Enriched, Wang et al 2003  S4 genes                              
                                              pass two-wayANOVA P0                                                               

D1054.5 Aff_D1054.5 P W All gene names: D1054.5; 5L254; CE35446; WBGene00008372; WP:CE35446
EGAP2.3 Aff_EGAP2.3 P W All gene names: pho-1; EGAP2.3; EGAP2.3.1; EGAP2.3.2; 2F524; CE04325; NM_062582; WBGene00004020; WP:CE04325 WormBase description: pho-1 encodes the major C. elegans intestinal acid phosphatase; as loss of PHO-1 function via RNA-mediated interference (RNAi) does not result in any abnormalities, PHO-1 may function redundantly with other acid phosphatases; PHO-1 intestinal expression appears to be positively regulated by CKI-1, a cyclin-dependent kinase inhibitor, and negatively regulated by POP-1, a TCF/LEF transcription factor; PHO-1 is expressed along the intestinal brush border in all gut cells except the most anterior int-1 and int-2 cells, beginning at the three-fold stage of embryogenesis.
                                              
Member of lists (Publications lists):
                                              Murphy et al 2003  Fig2 Class2 shorten                            
                                              lifespan, Reinke et al 2004, list of genes in cluster                              
                                              order, Reinke et al 2004, list of genes in cluster C,                              
                                              Wang et al 2003  S4 Early genes, Wang et al 2003  S3                               
                                              genes pass one-way ANOVA, Wang et al 2003  S4 genes                                
                                              pass two-wayANOVA P0                                                               

F01F1.9 Aff_F01F1.9 P W All gene names: F01F1.9; 3G952; CE01235; WBGene00017163; WP:CE01235
                                              
Member of lists (Publications lists):
                                              McCarroll et al 2004  SFig5 conserved                             
                                              w/ yeast, Reinke et al 2004, list of genes in cluster                              
                                              order, Reinke et al 2004, list of genes in cluster C,                              
                                              ViswanathanM et al 2005  S2 sir-2.1 regulated, Wang et                             
                                              al 2003  S5 genes common to feeding ANOVA, Wang et al                              
                                              2003  S3  genes pass one-way ANOVA                                                 

F08H9.6 Aff_F08H9.6 P W All gene names: clec-57; F08H9.6; F08H9.6.1; F08H9.6.2; 5O951; CE31901; WBGene00008594; WP:CE31901 WormBase description: C-type lectin domain
                                              
Member of lists (Publications lists):
                                              ReichertK et al 2005  T2 xenobiotic                               
                                              induced C-type, Reinke et al 2004, list of genes in                                
                                              cluster order, Reinke et al 2004, list of genes in                                 
                                              cluster C, Reinke et al 2004, herm soma enriched genes,                            
                                              ViswanathanM et al 2005  S2 daf-16 Resveratrol,                                    
                                              ViswanathanM et al 2005  S2 sir-2.1 regulated, Wang et                             
                                              al 2003  S3  genes pass one-way ANOVA, Wang et al 2003                             
                                              S4 Early genes, Wang et al 2003  S4 genes pass                                     
                                              two-wayANOVA P0                                                                    

F09F7.4 Aff_F09F7.4 P W All gene names: F09F7.4; F09F7.4a.1; F09F7.4a.2; F09F7.4b.1; F09F7.4b.2; F09F7.4b.3; 3G645; CE00689; CE30654; WBGene00017301; WP:CE00689; WP:CE30654 WormBase description: Enoyl-CoA hydratase
                                              
Member of lists (Publications lists):
                                              McCarroll et al 2004  SFig5 conserved                             
                                              w/ yeast, McCarroll et al 2004  SFig1-4 conserved w/                               
                                              Drosoph, ViswanathanM et al 2005  S2 sir-2.1 regulated,                            
                                              Wang et al 2003  S4 Early genes, Wang et al 2003  S3                               
                                              genes pass one-way ANOVA, Wang et al 2003  S4 genes                                
                                              pass two-wayANOVA P0                                                               

F19B2.5 Aff_F19B2.C P W All gene names: F19B2.5; F19B2.C; 5U632; CE20697; WBGene00008944; WP:CE20697
                                              
Member of lists (Publications lists):
                                              Reinke et al 2004, list of genes in                               
                                              cluster order, Reinke et al 2004, list of genes in                                 
                                              cluster B, ViswanathanM et al 2005  S2 sir-2.1                                     
                                              regulated, Zhang et al 2002, T1 mec-3 dependent genes                              

F25B4.8 Aff_F25B4.8 P W All gene names: F25B4.8; 5G170; CE30761; CE30762; WBGene00017771; WP:CE30761; WP:CE30762
                                              
Member of lists (Publications lists):
                                              ViswanathanM et al 2005  S2 sir-2.1                               
                                              regulated                                                                          

F25B5.3 Aff_F25B5.3 P W All gene names: F25B5.3; F25B5.3c.1; F25B5.3c.2; F25B5.3c.3; F25B5.3c.4; 3H41; CE26890; CE28001; CE29776; CE30663; CE30664; WBGene00017775; WP:CE26890; WP:CE28001; WP:CE29776; WP:CE30663; WP:CE30664 WormBase description: F25B5.3 is orthologous to the human gene NUCLEOTIDASE, 5-PRIME, CYTOSOLIC III (NT5C3; OMIM:606224), which when mutated leads to hemolytic anemia due to UMPH1 deficiency
                                              
Member of lists (Publications lists):
                                              McCarroll et al 2004  SFig1-4                                     
                                              conserved w/ Drosoph, ViswanathanM et al 2005  S2                                  
                                              sir-2.1 regulated, ViswanathanM et al 2005  S2 daf-16                              
                                              Resveratrol, Wang et al 2003  S3  genes pass one-way                               
                                              ANOVA, Wang et al 2003  S4 Dauer Enriched, Wang et al                              
                                              2003  S4 genes pass two-wayANOVA P0                                                

F26D10.3 Aff_F26D10.3 P W All gene names: hsp-1; F26D10.3; F26D10.3.1; F26D10.3.2; F26D10.3.3; T28F3.2; 4S223; CE09682; NM_070667; WBGene00002005; WP:CE09682 WormBase description: hsp-1 encodes hsp70A, a member of the heat shock family of proteins; hsp70A is closely related to the Drosophila heat inducible hsp70s and the S. cerevisiae SSA hsp70 subfamily; the hsp-1 gene is normally expressed throughout development and upon heat-shock the hsp-1 mRNA is enhanced 2-6 fold; down-regulation of hsp-1 via RNA interference results in a small reduction in the life-span of an age-1 mutant indicating that hsp-1 may play some role in regulating longevity. WormBase CDS description: HSP-1 heat shock 70kd protein A
                                              
Member of lists (Publications lists):
                                              Custodia et al 2001  T2 heat shock,                               
                                              Lund et al 2002 Aging time course Fig2C heatshock,                                 
                                              McCarroll et al 2004  SFig5 conserved w/ yeast,                                    
                                              McCarroll et al 2004  SFig1-4 conserved w/ Drosoph,                                
                                              Reinke et al 2004, intrinsic, Reinke et al 2004, wt vs                             
                                              glp-4 enriched genes, Romagnolo et al 2002  Fig2a heat                             
                                              shock, ViswanathanM et al 2005  S2 sir-2.1 regulated                               

F26H11.5 Aff_F26H11.5 P W All gene names: exl-1; F26H11.5; 2O698; CE24922; NM_064599; WBGene00001371; WP:CE24922
                                              
Member of lists (Publications lists):
                                              Reinke et al 2004, mixed sperm soma,                              
                                              Reinke et al 2004, fem3 enriched genes, ViswanathanM et                            
                                              al 2005  S2 sir-2.1 regulated                                                      

F29B9.8 Aff_F29B9.8 P W All gene names: F29B9.8; F29B9.8.1; F29B9.8.2; 4F413; CE09786; WBGene00017923; WP:CE09786
                                              
Member of lists (Publications lists):
                                              Reinke et al 2004, list of genes in                               
                                              cluster order                                                                      

F35C5.10 Aff_F35C5.10 P W All gene names: nspb-11; F35C5.10; 2N197; CE15951; WBGene00009398; WP:CE15951
                                              
Member of lists (Publications lists):
                                              Reinke et al 2004, list of genes in                               
                                              cluster order, Reinke et al 2004, list of genes in                                 
                                              cluster C, ViswanathanM et al 2005  S2 sir-2.1                                     
                                              regulated                                                                          

F35C8.6 Aff_F35C8.6 P W All gene names: pfn-2; F35C8.6; CE39098; NM_076509; WBGene00003990; WP:CE39098; XF972
                                              
Member of lists (Publications lists):
                                              Reinke et al 2004, list of genes in                               
                                              cluster order, Reinke et al 2004, list of genes in                                 
                                              cluster C, ViswanathanM et al 2005  S2 daf-16                                      
                                              Resveratrol, Wang et al 2003  S3  genes pass one-way                               
                                              ANOVA, Wang et al 2003  S4 Dauer Enriched, Wang et al                              
                                              2003  S4 genes pass two-wayANOVA P0                                                

F44E7.4 Aff_F44E7.4 P W All gene names: F44E7.4; F44E7.4c.1; F44E7.4c.2; 5G254; CE10402; CE30799; CE33092; CE37110; WBGene00018426; WP:CE10402; WP:CE30799; WP:CE33092; WP:CE37110 WormBase description: This gene encodes a protein predicted by Eisenberg and coworkers, with 68% accuracy, to be mitochondrial.
                                              
Member of lists (Publications lists):
                                              McCarroll et al 2004  SFig5 conserved                             
                                              w/ yeast, McCarroll et al 2004  SFig1-4 conserved w/                               
                                              Drosoph, Romagnolo et al 2002  Fig3b Proteases,                                    
                                              ViswanathanM et al 2005  S2 sir-2.1 regulated, Wang et                             
                                              al 2003  S4 Early genes, Wang et al 2003  S3  genes                                
                                              pass one-way ANOVA, Wang et al 2003  S4 genes pass                                 
                                              two-wayANOVA P0                                                                    

F54E2.1 Aff_F54E2.1 P W All gene names: F54E2.1; 5D289; CE30806; WBGene00018823; WP:CE30806
                                              
Member of lists (Publications lists):
                                              Murphy et al 2003  Fig2 Class2 shorten                            
                                              lifespan, ViswanathanM et al 2005  S2 sir-2.1                                      
                                              regulated, Wang et al 2003  S5 genes common to feeding                             
                                              ANOVA, Wang et al 2003  S3  genes pass one-way ANOVA                               

F54F11.2 Aff_F54F11.2 P W All gene names: F54F11.2; 2N805; CE11095; WBGene00010070; WP:CE11095 WormBase description: F54F11.2 encodes a neprilysin; neprilysins are thermolysin-like zinc metallopeptidases, found on the outer surface of animal cells, that negatively regulate small signalling peptides (e.g., enkephalin, tachykinin, insulin, and natriuretic peptides) by cleaving them; F54F11.2 has no clear orthologs in other organisms. WormBase CDS description: Zinc-binding metalloprotease
                                              
Member of lists (Publications lists):
                                              Murphy et al 2003  Fig2 Class2 shorten                            
                                              lifespan, Reinke et al 2004, intrinsic, Reinke et al                               
                                              2004, wt vs glp-4 enriched genes, Reinke et al 2004,                               
                                              list of genes in cluster order, Reinke et al 2004, list                            
                                              of genes in cluster C, Reinke et al 2004, GO                                       
                                              categories, ViswanathanM et al 2005  S2 sir-2.1                                    
                                              regulated                                                                          

K02D7.4 Aff_K02D7.4 P W All gene names: dsc-4; K02D7.4; K02D7.4.1; K02D7.4.2; 4B68; CE33667; NM_067502; WBGene00001099; WP:CE33667 WormBase description: Uncloned locus that affects the length of the defecation cycle and genetically interacts with clk-1 with respect to defecation cycle length, and also with respect to the clk-1- dependent adjustment of defecation cycle length to temperature.
                                              
Member of lists (Publications lists):
                                              Reinke et al 2004, list of genes in                               
                                              cluster order, Reinke et al 2004, list of genes in                                 
                                              cluster C, ViswanathanM et al 2005  S2 daf-16                                      
                                              Resveratrol                                                                        

K08E3.1 Aff_K08E3.1 P W All gene names: tyr-2; K08E3.1; 3O835; CE18864; NM_067435; WBGene00010661; WP:CE18864 WormBase description: tyrosinase
                                              
Member of lists (Publications lists):
                                              Reinke et al 2004, list of genes in                               
                                              cluster order, Reinke et al 2004, list of genes in                                 
                                              cluster B, Shen et al 2005  T1 hif-1 depend hypoxia                                

K08F8.1 Aff_K08F8.1 P W All gene names: K08F8.1; K08F8.1a.1; K08F8.1a.2; K08F8.1a.3; K08F8.1a.4; K08F8.1b.1; K08F8.1b.2; K08F8.1c.1; K08F8.1c.2; K08F8.1c.3; K08F8.1c.4; K08F8.1d.1; K08F8.1d.2; K08F8.1e.1; K08F8.1e.2; K08F8.1e.3; K08F8.1e.4; K08F8.1e.5; K08F8.1e.6; 2J37; CE03467; CE32906; CE35895; CE37257; CE37258; WBGene00010681; WP:CE03467; WP:CE32906; WP:CE35895; WP:CE37257; WP:CE37258 WormBase description: ribosomal S6 kinase
                                              
Member of lists (Publications lists):
                                              ViswanathanM et al 2005  S2 sir-2.1                               
                                              regulated                                                                          

K11D12.5 Aff_K11D12.5 P W All gene names: K11D12.5; 5F508; CE12134; WBGene00019645; WP:CE12134
                                              
Member of lists (Publications lists):
                                              Reinke et al 2004, list of genes in                               
                                              cluster order, Reinke et al 2004, list of genes in                                 
                                              cluster C, ViswanathanM et al 2005  S2 daf-16                                      
                                              Resveratrol                                                                        

K12C11.3 Aff_K12C11.3 P W All gene names: K12C11.3; 1B809; CE34341; WBGene00019674; WP:CE34341
R09A8.3 Aff_R09A8.3 P W All gene names: tag-147; R09A8.3; R09A8.3.1; R09A8.3.2; R09A8.3.3; CE03539; WBGene00006493; WP:CE03539; XN244 WormBase description: ring canal like protein
                                              
Member of lists (Publications lists):
                                              ViswanathanM et al 2005  S2 sir-2.1                               
                                              regulated                                                                          

R10E11.2 Aff_R10E11.2 P W All gene names: vha-2; R10E11.2; R10E11.2.1; R10E11.2.2; R10E11.2.3; 3K875; CE06290; NM_066765; WBGene00006911; WP:CE06290 WormBase description: vha-2 encodes a 16-kDa proteolipid of the vacuolar-type H+-ATPase (V-ATPase) not required for embryonic viability; VHA-2 is 100% identical to VHA-3 with respect to amino acid sequence; vha-2 is located in a polycistronic region with vha-1 and it is expressed in the excretory cell, rectum, and a pair of cells posterior to the anus. WormBase CDS description: Vacuolar ATP synthase subunit
                                              
Member of lists (Publications lists):
                                              ViswanathanM et al 2005  S2 sir-2.1                               
                                              regulated                                                                          

R10E11.8 Aff_R10E11.8 P W All gene names: vha-1; R10E11.8; R10E11.8.1; R10E11.8.2; R10E11.8.3; 3K871; CE06291; NM_066764; WBGene00006910; WP:CE06291 WormBase description: vha-1 encodes a 16-kDa proteolipid of the vacuolar-type H+-ATPase (V-ATPase) and is required for embryogenesis and for oocyte ovulation, based on RNAi analysis; expressed in the excretory cells and the rectum of adult animals as well as in a pair of cells posterior to the anus. WormBase CDS description: ATP synthase subunit C (2 domains)
                                              
Member of lists (Publications lists):
                                              Reinke et al 2004, list of genes in                               
                                              cluster order, Reinke et al 2004, list of genes in                                 
                                              cluster C                                                                          

R11A5.4 Aff_R11A5.4 P W All gene names: R11A5.4; R11A5.4c.1; R11A5.4c.2; R11A5.4c.3; R11A5.4d.1; R11A5.4d.2; R11A5.4d.3; R11A5.4d.4; R11A5.4d.5; 1I447; CE12728; CE36358; CE36359; CE36360; WBGene00011232; WP:CE12728; WP:CE36358; WP:CE36359; WP:CE36360 WormBase description: phosphoenolpyruvate carboxykinase
                                              
Member of lists (Publications lists):
                                              McCarroll et al 2004  SFig1-4                                     
                                              conserved w/ Drosoph, Murphy et al 2003  Fig2 Class1                               
                                              elongate lifespan, ViswanathanM et al 2005  S2 sir-2.1                             
                                              regulated                                                                          

R11D1.11 Aff_R11D1.11 P W All gene names: dhs-21; R11D1.11; 5N212; CE39954; NM_073781; WBGene00000984; WP:CE39954 WormBase description: dhs-21 encodes a member of the short-chain dehydrogenases/reductases family (SDR) expressed in the intestine, hypodermis, uterus, and spermatheca. WormBase CDS description: Mouse adipocyte P27 protein like
                                              
Member of lists (Publications lists):
                                              McCarroll et al 2004  SFig1-4                                     
                                              conserved w/ Drosoph, Reinke et al 2004, list of genes                             
                                              in cluster order, Reinke et al 2004, list of genes in                              
                                              cluster B, ViswanathanM et al 2005  S2 sir-2.1                                     
                                              regulated, ViswanathanM et al 2005  S2 daf-16                                      
                                              Resveratrol                                                                        

R12H7.2 Aff_R12H7.2 P W All gene names: asp-4; R12H7.2; CE03567; NM_077790; WBGene00000217; WP:CE03567; XN838 WormBase description: asp-4 encodes an aspartyl protease homolog that is required, in parallel with ASP-3 but downstream of CLP-1 and TRA-3, for degenerative (necrotic-like) cell death in neurons induced by mutations such as mec-4(d), deg-3(d), or gsa-1(gf). WormBase CDS description: aspartyl protease
                                              
Member of lists (Publications lists):
                                              McCarroll et al 2004  SFig5 conserved                             
                                              w/ yeast, McCarroll et al 2004  SFig1-4 conserved w/                               
                                              Drosoph, ViswanathanM et al 2005  S2 sir-2.1 regulated                             

R13F6.3 Aff_R13F6.3 P W All gene names: srg-12; srv-1; R13F6.3; 3H943; CE33437; NM_066088; WBGene00005712; WP:CE33437 WormBase description: 7TM chemoreceptor, srv family
                                              
Member of lists (Publications lists):
                                              Reinke et al 2004, herm soma enriched                             
                                              genes, ViswanathanM et al 2005  S2 sir-2.1 regulated                               

T02E1.4 Aff_T02E1.4 P W All gene names: T02E1.4; 1I792; CE13052; WBGene00011377; WP:CE13052 WormBase description: dehydrogenase
                                              
Member of lists (Publications lists):
                                              Romagnolo et al 2002  Fig3b Unkown,                               
                                              ViswanathanM et al 2005  S2 sir-2.1 regulated, Wang et                             
                                              al 2003  S3  genes pass one-way ANOVA, Wang et al 2003                             
                                              S4 Dauer Enriched, Wang et al 2003  S4 genes pass                                  
                                              two-wayANOVA P0                                                                    

T03E6.7 Aff_T03E6.7 P W All gene names: cpl-1; T03E6.7; T03E6.7.1; T03E6.7.2; 5R74; CE16333; NM_074798; WBGene00000776; WP:CE16333 WormBase description: cpl-1 encodes a member of the cathepsin L-like cysteine protease family required for embryonic viability and normal growth; expressed in eggshells and throughout early embryos, accumulates in intestinal cells during late embryogenesis, and expressed in the cuticle, gonad, and pharynx later in development. WormBase CDS description: cathepsin-like protease
                                              
Member of lists (Publications lists):
                                              McCarroll et al 2004  SFig1-4                                     
                                              conserved w/ Drosoph, Murphy et al 2003  Fig2 Class2                               
                                              shorten lifespan, Reinke et al 2004, fem3 enriched                                 
                                              genes, Reinke et al 2004, mixed sperm soma, Reinke et                              
                                              al 2004, GO categories, ViswanathanM et al 2005  S2                                
                                              sir-2.1 regulated, Wang et al 2003  S3  genes pass                                 
                                              one-way ANOVA, Wang et al 2003  S4 genes pass                                      
                                              two-wayANOVA P0, Wang et al 2003  S4 Dauer Enriched                                

T05E7.1 Aff_T05E7.1 P W All gene names: T05E7.1; 1G781; CE13231; WBGene00020258; WP:CE13231
                                              
Member of lists (Publications lists):
                                              Reinke et al 2004, list of genes in                               
                                              cluster order, Reinke et al 2004, fem3 enriched genes,                             
                                              Reinke et al 2004, wt herm vs wt male enriched gen,                                
                                              Reinke et al 2004, mixed sperm soma, Reinke et al 2004,                            
                                              GO categories, Reinke et al 2004, herm soma enriched                               
                                              genes, Reinke et al 2004, list of genes in cluster B,                              
                                              ViswanathanM et al 2005  S2 sir-2.1 regulated, Wang et                             
                                              al 2003  S3  genes pass one-way ANOVA, Wang et al 2003                             
                                              S4 Early genes, Wang et al 2003  S4 genes pass                                     
                                              two-wayANOVA P0                                                                    

T06C12.10 Aff_T06C12.10 P W All gene names: tag-217; T06C12.10; T06C12.10.1; T06C12.10.2; 5Q366; CE31986; WBGene00011517; WP:CE31986
                                              
Member of lists (Publications lists):
                                              Reinke et al 2004, list of genes in                               
                                              cluster A, Reinke et al 2004, list of genes in cluster                             
                                              order, Wang et al 2003  S3  genes pass one-way ANOVA,                              
                                              Wang et al 2003  S4 Dauer Enriched, Wang et al 2003  S4                            
                                              genes pass two-wayANOVA P0                                                         

T15B7.1 Aff_T15B7.1 P W All gene names: T15B7.1; 5H327; CE37677; WBGene00020516; WP:CE37677
                                              
Member of lists (Publications lists):
                                              Jones et al 2001  Non dauer genes                                 
                                              P<0.05, Reinke et al 2004, herm soma enriched genes,                               
                                              ViswanathanM et al 2005  S2 sir-2.1 regulated, Wang et                             
                                              al 2003  S4 Early genes, Wang et al 2003  S3  genes                                
                                              pass one-way ANOVA, Wang et al 2003  S4 genes pass                                 
                                              two-wayANOVA P0                                                                    

T15B7.2 Aff_T15B7.2 P W All gene names: T15B7.2; T15B7.2.1; T15B7.2.2; 5H319; CE33319; WBGene00020517; WP:CE33319
                                              
Member of lists (Publications lists):
                                              McCarroll et al 2004  SFig5 conserved                             
                                              w/ yeast, McCarroll et al 2004  SFig1-4 conserved w/                               
                                              Drosoph, Reinke et al 2004, herm soma enriched genes,                              
                                              Wang et al 2003  S4 Climbing, Wang et al 2003  S3                                  
                                              genes pass one-way ANOVA, Wang et al 2003  S4 genes                                
                                              pass two-wayANOVA P0                                                               

T20G5.2 Aff_T20G5.2 P W All gene names: cts-1; T20G5.2; T20G5.2.1; T20G5.2.2; 3L304; CE00513; NM_066863; WBGene00000833; WP:CE00513 WormBase description: cts-1 encodes a citrate synthase, predicted to be mitochondrial, that is required for embryonic development. WormBase CDS description: Citrate synthase
                                              
Member of lists (Publications lists):
                                              McCarroll et al 2004  SFig5 conserved                             
                                              w/ yeast, McCarroll et al 2004  SFig1-4 conserved w/                               
                                              Drosoph, Reinke et al 2004, list of genes in cluster                               
                                              order, Reinke et al 2004, list of genes in cluster C,                              
                                              ViswanathanM et al 2005  S2 sir-2.1 regulated                                      

T21B4.2 Aff_T21B4.2 P W All gene names: col-85; T21B4.2; 2M782; CE16427; NM_064264; WBGene00000660; WP:CE16427 WormBase description: collagen
                                              
Member of lists (Publications lists):
                                              Reinke et al 2004, wt herm vs wt herm                             
                                              enriched gen                                                                       

T22H2.6 Aff_T22H2.6 P W All gene names: T22H2.6; 1M295; CE24004; CE24005; WBGene00011936; WP:CE24004; WP:CE24005 WormBase description: granulin precursor
                                              
Member of lists (Publications lists):
                                              ViswanathanM et al 2005  S2 sir-2.1                               
                                              regulated                                                                          

T27E4.4 Aff_T27E4.4 P W All gene names: T27E4.4; 5J547; CE14253; WBGene00020862; WP:CE14253
T27E4.7 Aff_T27E4.7 P W All gene names: T27E4.7; T27E4.7.1; T27E4.7.2; 5J556; CE14259; WBGene00020865; WP:CE14259
                                              
Member of lists (Publications lists):
                                              Lund et al 2002  Fig4 Mount 15                                    

T28H10.3 Aff_T28H10.3 P W All gene names: T28H10.3; 5M993; CE14367; WBGene00012144; WP:CE14367 WormBase description: vacuolar processing enzyme like
                                              
Member of lists (Publications lists):
                                              Lund et al 2002  Fig4 Mount 15,                                   
                                              ViswanathanM et al 2005  S2 daf-16 Resveratrol                                     

VC5.3 Aff_VC5.1 P W All gene names: npa-1; VC5.3; VC5.3b.1; VC5.3b.2; 5H561; CE21224; CE33332; CE36211; NM_072394; NM_182438; WBGene00003786; WP:CE21224; WP:CE33332; WP:CE36211 WormBase description: npa-1 encodes a large polyprotein precursor that is posttranslationally cleaved to multiple units of ~14.5kDa, each of which is a strong binding protein for fatty acids and retinol (Vitamin A); the lipid binding sites of NPA-1-derived peptides are unusually apolar; NPA-1-derived peptides probably are carrier proteins that enable distribution of these lipids within nematodes; NPA-1-derived peptides are also secreted by parasitic nematode species.
                                              
Member of lists (Publications lists):
                                              Murphy et al 2003  Fig2 Class1                                    
                                              elongate lifespan, Reinke et al 2004, list of genes in                             
                                              cluster order, Reinke et al 2004, list of genes in                                 
                                              cluster C                                                                          

W01A11.1 Aff_W01A11.1 P W All gene names: W01A11.1; W01A11.1.1; W01A11.1.2; 5G981; CE14390; WBGene00020909; WP:CE14390 WormBase description: epoxide hydrolase
                                              
Member of lists (Publications lists):
                                              McCarroll et al 2004  SFig1-4                                     
                                              conserved w/ Drosoph, ViswanathanM et al 2005  S2                                  
                                              sir-2.1 regulated                                                                  

W02D9.10 Aff_W02D9.10 P W All gene names: W02D9.10; 1N143; CE14472; WBGene00012216; WP:CE14472
                                              
Member of lists (Publications lists):
                                              GuhaThakurta et al 2002  T1 upregu on                             
                                              heat stress, Lund et al 2002  Fig4 Mount 15, Reinke et                             
                                              al 2004, list of genes in cluster A, Reinke et al 2004,                            
                                              list of genes in cluster order, Reinke et al 2004, wt                              
                                              herm vs wt herm enriched gen, Reinke et al 2004, IVb                               
                                              male soma enriched genes, Shen et al 2005  T1                                      
                                              hif-1indepen hypoxia, ViswanathanM et al 2005  S2                                  
                                              daf-16 Resveratrol, ViswanathanM et al 2005  Fig6A                                 
                                              Ethanol HS, Wang et al 2003  S3  genes pass one-way                                
                                              ANOVA, Wang et al 2003  S4 genes pass two-wayANOVA P0,                             
                                              Wang et al 2003  S4 Dauer Enriched                                                 

W04B5.1 Aff_W04B5.1 P W All gene names: W04B5.1; 3D519; CE28846; WBGene00021018; WP:CE28846
                                              
Member of lists (Publications lists):
                                              Jones et al 2001  Non dauer genes                                 
                                              P<0.05                                                                             

W07G4.4 Aff_W07G4.4 P W All gene names: W07G4.4; 5N525; CE03794; WBGene00012338; WP:CE03794 WormBase description: This gene encodes a protein predicted by Eisenberg and coworkers, with 68% accuracy, to be mitochondrial. WormBase CDS description: cytosolic aminopeptidase
                                              
Member of lists (Publications lists):
                                              McCarroll et al 2004  SFig1-4                                     
                                              conserved w/ Drosoph, ViswanathanM et al 2005  S2                                  
                                              sir-2.1 regulated                                                                  

W09D12.1 Aff_W09D12.1 P W All gene names: W09D12.1; W09D12.1.1; W09D12.1.2; W09D12.1.3; 5P398; CE33197; WBGene00012364; WP:CE33197 WormBase description: zinc metalloprotease
                                              
Member of lists (Publications lists):
                                              Wang et al 2003  S3  genes pass                                   
                                              one-way ANOVA, Wang et al 2003  S4 Dauer Enriched, Wang                            
                                              et al 2003  S4 genes pass two-wayANOVA P0                                          

Y106G6H.1 Aff_Y106G6H.1 P W All gene names: Y106G6H.1; 1L7; CE20411; WBGene00013716; WP:CE20411
Y37D8A.6 Aff_Y37D8A.6 P W All gene names: Y37D8A.6; 3N948; CE20211; WBGene00012548; WP:CE20211
Y39D8C.1 Aff_Y39D8C.1 P W All gene names: abt-4; Y39D8C.1; 5A802; CE20234; NM_070774; WBGene00000022; WP:CE20234 WormBase description: abt-4 encodes a predicted ATP-binding cassette (ABC) transporter that is a member of the ABCA subfamily of transport proteins; ABT-4 is predicted to function as a transmembrane protein that couples energy to transport of various molecules across membranes, but as loss of abt-4 activity via RNAi results in no obvious defects, the precise role of abt-4 in C. elegans development and/or behavior is not yet known; abt-4 promoter-gfp fusion proteins are widely expressed in larvae and adults, with expression seen in the pharynx, the pharyngeal-intestinal valve, the intestine, renal gland cells, hypodermis, various neurons, and unidentified cells in the head and tail. WormBase CDS description: ABC transporter
                                              
Member of lists (Publications lists):
                                              McCarroll et al 2004  SFig1-4                                     
                                              conserved w/ Drosoph, Reinke et al 2004, list of genes                             
                                              in cluster order, Reinke et al 2004, list of genes in                              
                                              cluster C                                                                          

Y40B10A.2 Aff_Y40B10A_107.A P W All gene names: Y40B10A.2; 5C541; CE21796; WBGene00021487; WP:CE21796
                                              
Member of lists (Publications lists):
                                              Murphy et al 2003  Fig2 Class1                                    
                                              elongate lifespan, Reinke et al 2004, list of genes in                             
                                              cluster order, Reinke et al 2004, list of genes in                                 
                                              cluster C, ViswanathanM et al 2005  S2 sir-2.1                                     
                                              regulated                                                                          

Y43F8C.1 Aff_Y116F11.XX P W All gene names: nlp-25; Y43F8C.1; 5U81; CE21899; NM_075400; WBGene00003763; WP:CE21899
                                              
Member of lists (Publications lists):
                                              Bishop et al 2004  T4 57 vhl-1 depend                             
                                              hif-1 indep, ReichertK et al 2005  T3 xenobiotic                                   
                                              downregulated, Reinke et al 2004, list of genes in                                 
                                              cluster order, Reinke et al 2004, wt herm vs wt herm                               
                                              enriched gen, Reinke et al 2004, IVb male soma enriched                            
                                              genes, Reinke et al 2004, list of genes in cluster B,                              
                                              ViswanathanM et al 2005  S2 daf-16 Resveratrol,                                    
                                              ViswanathanM et al 2005  S2 sir-2.1 regulated, Wang et                             
                                              al 2003  S3  genes pass one-way ANOVA, Wang et al 2003                             
                                              S4 Early genes, Wang et al 2003  S4 genes pass                                     
                                              two-wayANOVA P0                                                                    

Y47G6A.22 Aff_Y47G6A_245.C P W All gene names: Y47G6A.22; Y47G6A_245.C; 1E128; CE24368; WBGene00021647; WP:CE24368
                                              
Member of lists (Publications lists):
                                              ViswanathanM et al 2005  S2 sir-2.1                               
                                              regulated, Wang et al 2003  S4 Climbing, Wang et al                                
                                              2003  S3  genes pass one-way ANOVA, Wang et al 2003  S4                            
                                              genes pass two-wayANOVA P0                                                         

Y49E10.18 Aff_Y49E10.R P W All gene names: Y49E10.18; Y49E10.R; 3N532; CE33877; WBGene00013037; WP:CE33877
                                              
Member of lists (Publications lists):
                                              Reinke et al 2004, list of genes in                               
                                              cluster order, Reinke et al 2004, list of genes in                                 
                                              cluster B                                                                          

Y50E8A.3 Aff_Y50E8A.C P W All gene names: oig-3; Y50E8A.3; 5P207; CE22305; NM_074236; WBGene00003861; WP:CE22305
Y51A2B.1 Aff_Y51A2B.1 P W All gene names: Y51A2B.1; 5S847; CE16655; WBGene00013065; WP:CE16655
                                              
Member of lists (Publications lists):
                                              Murphy et al 2003  Fig2 Class1                                    
                                              elongate lifespan                                                                  

Y66A7A.7 Aff_Y66A7A.7 P W All gene names: Y66A7A.7; 3M718; CE20344; WBGene00013426; WP:CE20344
Y71F9B.13 Aff_Y71F9A_284.A P W All gene names: Y71F9B.13; Y71F9B.13c.1; Y71F9B.13c.2; 1D346; CE25566; CE25567; CE33244; WBGene00022131; WP:CE25566; WP:CE25567; WP:CE33244
ZC434.9 Aff_ZC434.9 P W All gene names: ZC434.9; 1K935; CE25665; CE36256; WBGene00013895; WP:CE25665; WP:CE36256 WormBase description: carboxypeptidase
                                              
Member of lists (Publications lists):
                                              Reinke et al 2004, list of genes in                               
                                              cluster order, Reinke et al 2004, list of genes in                                 
                                              cluster C                                                                          

ZK1058.9 Aff_ZK1058.9 P W All gene names: ZK1058.9; 3F14; CE01107; WBGene00014207; WP:CE01107
                                              
Member of lists (Publications lists):
                                              Reinke et al 2004, list of genes in                               
                                              cluster order, Reinke et al 2004, list of genes in                                 
                                              cluster C, Wang et al 2003  S6 removed genes of                                    
                                              contamination                                                                      

ZK112.1 Aff_ZK112.1 P W All gene names: pcp-1; ZK112.1; 3I849; CE25679; NM_066287; WBGene00003956; WP:CE25679
                                              
Member of lists (Publications lists):
                                              Reinke et al 2004, list of genes in                               
                                              cluster A, Reinke et al 2004, list of genes in cluster                             
                                              order, ViswanathanM et al 2005  S2 sir-2.1 regulated,                              
                                              ViswanathanM et al 2005  S2 daf-16 Resveratrol                                     

ZK688.3 Aff_ZK688.3 P W All gene names: ZK688.3; 3I983; CE00461; WBGene00022798; WP:CE00461
                                              
Member of lists (Publications lists):
                                              McCarroll et al 2004  SFig5 conserved                             
                                              w/ yeast, McCarroll et al 2004  SFig1-4 conserved w/                               
                                              Drosoph, ViswanathanM et al 2005  S2 sir-2.1 regulated                             

ZK809.3 Aff_ZK809.3 P W All gene names: ZK809.3; ZK809.3.1; ZK809.3.2; 4M417; CE03831; WBGene00014086; WP:CE03831
                                              
Member of lists (Publications lists):
                                              McCarroll et al 2004  SFig1-4                                     
                                              conserved w/ Drosoph, Romagnolo et al 2002  Fig3b                                  
                                              Unkown, ViswanathanM et al 2005  S2 sir-2.1 regulated