Golden et al 2004, N2 vs daf-2 age different gene, 19 genes

Gene list file name:Golden2004_T1_N2_vs_daf2_age_differ_genes.txt
Type of gene identifier:MA primer pair (sjj)
Description:Golden et al 2004, Table 1, Genes that differentiate N2 and daf-2 with respect to age  
Organism:Caenorhabditis elegans (nematode)
Gene list type:Experimental

Gene name             Source Gene ID          Annotation                                                  Date       Added by    

F09C6.5 F09C6.5 P W All gene names: srp-9; F09C6.5; 5R374; NM_074867; WBGene00005650
                                              
Member of lists (Publications lists):
                                              Golden et al 2004, N2 vs daf-2                                    
                                              different genes at , Golden et al 2004, N2 vs daf-2 age                            
                                              different gene, Reinke et al 2004, herm sperm, Reinke                              
                                              et al 2004, wt vs glp-4 enriched genes, Reinke et al                               
                                              2004, spermatogenesis enriched genes, Reinke et al                                 
                                              2004, wt herm vs wt herm enriched gen, Reinke et al                                
                                              2004, fem3 enriched genes                                                          

F28D1.5 F28D1.5 P W All gene names: thn-2; F28D1.5; 4N149; CE05745; NM_069961; WBGene00009215; WP:CE05745 WormBase description: Arabidopsis pathogenesis-related protein 5 like
                                              
Member of lists (Publications lists):
                                              Golden et al 2004, N2 differentially                              
                                              expressed gen, Golden et al 2004, daf-2 differentially                             
                                              expressed , Golden et al 2004, N2 vs daf-2 age                                     
                                              different gene, Jones et al 2001  Non dauer genes                                  
                                              P<0.05, Jones et al 2001  T3 20 most abundant                                      
                                              Mixed-stage, Murphy et al 2003  Fig2 Class1 elongate                               
                                              lifespan, ReichertK et al 2005  T3 xenobiotic                                      
                                              downregulated, ViswanathanM et al 2005  S2 sir-2.1                                 
                                              regulated                                                                          

F28H6.1 F28H6.1 P W All gene names: akt-2; F28H6.1; F28H6.1b.1; F28H6.1b.2; CE18646; CE29298; NM_077956; WBGene00000103; WP:CE18646; WP:CE29298; XO769 WormBase description: akt-2 encodes a homolog of the serine/threonine kinase Akt/PKB, AKT-2, that is required for progression through the dauer stage of development and for the negative regulation of adult lifespan; inactivation of akt-2 causes animals to arrest constitutively at the dauer stage, while having an increased life span; widely expressed, AKT-2 is activated by the phospholipid products of phosphoinositide 3-kinase AGE-1/PI3K and by PDK-1, a homolog of vertebrate 3-phosphoinositide-dependent kinase-1 (PDK-1) Normal akt-2 (and akt-1) activity is required for excess pdk-1 activity to suppress the dauer-arrest phenotype of age-1, indicating that the 3-phosphoinositide-dependent kinase-1 homolog PDK-1 transduces signals from AGE-1 to AKT-2 (and AKT-1); conversely, the akt-2 loss-of-function phenotype is suppressed by daf-16 null mutations, indicating that the Fork head transcription factor DAF-16 is downstream of AKT-2 (and AKT-1), and that AKT-1 and AKT-2 act primarily to antagonize DAF-16. WormBase CDS description: PH (pleckstrin homology) domain, Protein kinase C terminal domain
                                              
Member of lists (Publications lists):
                                              Golden et al 2004, N2 vs daf-2                                    
                                              different genes at , Golden et al 2004, N2 vs daf-2 age                            
                                              different gene, ViswanathanM et al 2005  S2 sir-2.1                                
                                              regulated, ViswanathanM et al 2005  S2 daf-16                                      
                                              Resveratrol                                                                        

F30F8.2 F30F8.2 P W All gene names: F30F8.2; 1I404; CE28553; WBGene00009271; WP:CE28553 WormBase description: glutaminase
                                              
Member of lists (Publications lists):
                                              Golden et al 2004, daf-2                                          
                                              differentially expressed , Golden et al 2004, N2 vs                                
                                              daf-2 different genes at , Golden et al 2004, N2 vs                                
                                              daf-2 age different gene, Reinke et al 2004, herm                                  
                                              sperm, Reinke et al 2004, list of genes in cluster                                 
                                              order, Reinke et al 2004, spermatogenesis enriched                                 
                                              genes, Reinke et al 2004, fem3 enriched genes, Reinke                              
                                              et al 2004, wt vs glp-4 enriched genes, Reinke et al                               
                                              2004, list of genes in cluster D                                                   

F36D3.9 F36D3.9 P W All gene names: cpr-2; F36D3.9; 5R14; CE30347; CPROT/2; NM_074785; WBGene00000782; WP:CE30347 WormBase description: cysteine protease
                                              
Member of lists (Publications lists):
                                              Bishop et al 2004  T4 57 vhl-1 depend                             
                                              hif-1 indep, Golden et al 2004, N2 vs daf-2 different                              
                                              genes at , Golden et al 2004, N2 vs daf-2 age different                            
                                              gene, Golden et al 2004, N2 differentially expressed                               
                                              gen, Jones et al 2001  T3 20 most abundant Dauer, Lund                             
                                              et al 2002  Fig1 aging-regulated genes, Murphy et al                               
                                              2003  Fig2 Class1 elongate lifespan, ViswanathanM et al                            
                                              2005  S2 daf-16 Resveratrol, ViswanathanM et al 2005                               
                                              S2 sir-2.1 regulated, Wang et al 2003  S8 SAGE genes in                            
                                              the dauer exit                                                                     

F40E10.1 F40E10.1 P W All gene names: hch-1; nas-34; F40E10.1; CE24964; NM_078039; WBGene00001828; WP:CE24964; XP316 WormBase description: hch-1 encodes a member of the zinc-dependent metalloprotease family that contains an epidermal growth factor-like domain, a CUB domain, and a TSP1 domain and affects hatching and QL neuroblast migration. WormBase CDS description: metalloprotease
                                              
Member of lists (Publications lists):
                                              Golden et al 2004, N2 vs daf-2                                    
                                              different genes at , Golden et al 2004, N2 vs daf-2 age                            
                                              different gene, Jones et al 2001  Non dauer genes                                  
                                              P<0.05                                                                             

F42A10.7 F42A10.7 P W All gene names: F42A10.7; F42A10.7.1; F42A10.7.2; 3H268; CE01298; WBGene00018343; WP:CE01298
                                              
Member of lists (Publications lists):
                                              Golden et al 2004, N2 differentially                              
                                              expressed gen, Golden et al 2004, N2 vs daf-2 age                                  
                                              different gene, Reinke et al 2004, wt herm vs wt herm                              
                                              enriched gen, ViswanathanM et al 2005  S2 sir-2.1                                  
                                              regulated                                                                          

F49A5.6 F49A5.6 P W All gene names: thn-4; F49A5.6; 5R346; CE16069; NM_074862; WBGene00009858; WP:CE16069 WormBase description: Thaumatin family
                                              
Member of lists (Publications lists):
                                              Golden et al 2004, N2 differentially                              
                                              expressed gen, Golden et al 2004, N2 vs daf-2 different                            
                                              genes at , Golden et al 2004, N2 vs daf-2 age different                            
                                              gene, Murphy et al 2003  Fig2 Class1 elongate lifespan                             

F49E12.2 F49E12.2 P W All gene names: dod-23; F49E12.2; 2I686; CE03379; NM_063366; WBGene00009898; WP:CE03379
                                              
Member of lists (Publications lists):
                                              Golden et al 2004, N2 vs daf-2                                    
                                              different genes at , Golden et al 2004, N2 vs daf-2 age                            
                                              different gene, Murphy et al 2003  Fig2 Class2 shorten                             
                                              lifespan, ReichertK et al 2005  T3 xenobiotic                                      
                                              downregulated, Reinke et al 2004, list of genes in                                 
                                              cluster order, Reinke et al 2004, herm soma enriched                               
                                              genes, ViswanathanM et al 2005  S2 sir-2.1 regulated                               

F49E8.5 F49E8.5 P W All gene names: dif-1; F49E8.5; F49E8.5.1; F49E8.5.2; 4I316; CE28408; NM_068822; WBGene00000996; WP:CE28408 WormBase description: dif-1 encodes a putative mitochondrial solute carrier, orthologous to human SLC25A20 (OMIM:212138, mutated in carnitine-acylcarnitine translocase deficiency) that is required for the maintenance of embryonic tissue differentiation and viability; expressed throughout development and in the intestinal cells and hypodermis of the embryo. WormBase CDS description: mitochondrial carrier family
                                              
Member of lists (Publications lists):
                                              Golden et al 2004, daf-2                                          
                                              differentially expressed , Golden et al 2004, N2 vs                                
                                              daf-2 age different gene, McCarroll et al 2004  SFig5                              
                                              conserved w/ yeast, McCarroll et al 2004  SFig1-4                                  
                                              conserved w/ Drosoph, ViswanathanM et al 2005  S2                                  
                                              sir-2.1 regulated, Wang et al 2003  S3  genes pass                                 
                                              one-way ANOVA, Wang et al 2003  S4 genes pass                                      
                                              two-wayANOVA P0, Wang et al 2003  S4 LateList                                      

F55F3.1 F55F3.1 P W All gene names: aakb-1; F55F3.1; F55F3.1.1; F55F3.1.2; CE18744; WBGene00010115; WP:CE18744; XO377
                                              
Member of lists (Publications lists):
                                              Golden et al 2004, N2 vs daf-2                                    
                                              different genes at , Golden et al 2004, N2 vs daf-2 age                            
                                              different gene, McCarroll et al 2004  SFig1-4 conserved                            
                                              w/ Drosoph, ViswanathanM et al 2005  S2 daf-16                                     
                                              Resveratrol                                                                        

K07G5.2 K07G5.2 P W All gene names: xpa-1; K07G5.2; 1H737; CE06130; NM_059624; WBGene00006963; WP:CE06130 WormBase description: xpa-1 encodes an ortholog of human XPA, the xeroderma pigmentosum complementation group A protein (OMIM:278700, mutations are associated with sensitivity to ultraviolet light and carcinomata at an early age); by homology, XPA-1 is predicted to function as a DNA-binding protein that is required for nucleotide excision repair of damaged DNA; in C. elegans, loss of xpa-1 activity via mutation or RNA-mediated interference (RNAi) results in increased sensitivity to UV irradiation at all stages of development; xpa-1 mRNA is detected in eggs and mixed stage populations. WormBase CDS description: DNA-repair protein XP-A homolog like
                                              
Member of lists (Publications lists):
                                              Golden et al 2004, N2 vs daf-2 age                                
                                              different gene, Golden et al 2004, N2 differentially                               
                                              expressed gen, McCarroll et al 2004  SFig1-4 conserved                             
                                              w/ Drosoph, Reinke et al 2004, list of genes in cluster                            
                                              order, Reinke et al 2004, intrinsic, Reinke et al 2004,                            
                                              wt vs glp-4 enriched genes, Reinke et al 2004, wt herm                             
                                              vs wt male enriched gen, Reinke et al 2004, GO                                     
                                              categories, Reinke et al 2004, list of genes in cluster                            
                                              E, ViswanathanM et al 2005  S2 sir-2.1 regulated                                   

M60.2 M60.1 P W All gene names: M60.2; M60.2.1; M60.2.2; CE28630; WBGene00019779; WP:CE28630; XI865
                                              
Member of lists (Publications lists):
                                              Golden et al 2004, N2 vs daf-2                                    
                                              different genes at , Golden et al 2004, N2 vs daf-2 age                            
                                              different gene, Golden et al 2004, N2 differentially                               
                                              expressed gen, Reinke et al 2004, wt herm vs wt male                               
                                              enriched gen, Reinke et al 2004, herm soma enriched                                
                                              genes, Wang et al 2003  S3  genes pass one-way ANOVA,                              
                                              Wang et al 2003  S4 Early genes, Wang et al 2003  S4                               
                                              genes pass two-wayANOVA P0                                                         

R07E5.2 R07E5.2 P W All gene names: prdx-3; R07E5.2; R07E5.2.1; R07E5.2.2; 3F499; CE00657; NM_065491; WBGene00011110; WP:CE00657; ceprx1 WormBase description: Mer5 (mouse)
                                              
Member of lists (Publications lists):
                                              Golden et al 2004, N2 vs daf-2 age                                
                                              different gene, Reinke et al 2004, list of genes in                                
                                              cluster order, Reinke et al 2004, list of genes in                                 
                                              cluster C, Romagnolo et al 2002  Fig3b Oxidation,                                  
                                              ViswanathanM et al 2005  S2 sir-2.1 regulated, Wang et                             
                                              al 2003  S3  genes pass one-way ANOVA, Wang et al 2003                             
                                              S4 Climbing, Wang et al 2003  S4 genes pass                                        
                                              two-wayANOVA P0                                                                    

T04C12.6 T04C12.6 P W All gene names: act-1; T04C12.6; T04C12.6.1; T04C12.6.2; T04C12.6.3; 5L561; CE13148; NM_073418; WBGene00000063; WP:CE13148 WormBase description: An actin that affects body wall and pharyngeal muscle structure and function and motility of animals. WormBase CDS description: actin
                                              
Member of lists (Publications lists):
                                              Golden et al 2004, daf-2                                          
                                              differentially expressed , Golden et al 2004, N2 vs                                
                                              daf-2 age different gene, Reinke et al 2004, list of                               
                                              genes in cluster order, Reinke et al 2004, list of                                 
                                              genes in cluster C                                                                 

T15B7.4 T15B7.4 P W All gene names: col-142; T15B7.4; 5H313; CE13654; NM_072335; WBGene00000715; WP:CE13654 WormBase description: collagen
                                              
Member of lists (Publications lists):
                                              Golden et al 2004, daf-2                                          
                                              differentially expressed , Golden et al 2004, N2 vs                                
                                              daf-2 different genes at , Golden et al 2004, N2 vs                                
                                              daf-2 age different gene, Reinke et al 2004, list of                               
                                              genes in cluster order, Reinke et al 2004, list of                                 
                                              genes in cluster C, ViswanathanM et al 2005  S2 sir-2.1                            
                                              regulated                                                                          

T27E9.2 T27E9.2 P W All gene names: T27E9.2; T27E9.2.1; T27E9.2.2; 3O550; CE14265; WBGene00012094; WP:CE14265 WormBase description: ubiquinol-cytochrome c reductase complexn 11 KD protein
                                              
Member of lists (Publications lists):
                                              Golden et al 2004, N2 vs daf-2                                    
                                              different genes at , Golden et al 2004, daf-2                                      
                                              differentially expressed , Golden et al 2004, N2 vs                                
                                              daf-2 age different gene                                                           

W09D10.3 W09D10.3 P W All gene names: W09D10.3; 3L797; CE16564; WBGene00012361; WP:CE16564 WormBase description: This gene encodes a protein predicted by Eisenberg and coworkers, with 52% accuracy, to be mitochondrial. WormBase CDS description: ribosomal protein L7/L12 mitochondrial
                                              
Member of lists (Publications lists):
                                              Golden et al 2004, N2 vs daf-2 age                                
                                              different gene, McCarroll et al 2004  SFig5 conserved                              
                                              w/ yeast, McCarroll et al 2004  SFig1-4 conserved w/                               
                                              Drosoph, ViswanathanM et al 2005  S2 sir-2.1 regulated,                            
                                              Wang et al 2003  S5 genes common to feeding ANOVA, Wang                            
                                              et al 2003  S3  genes pass one-way ANOVA                                           

Y38A8.2 Y38A8.2 P W All gene names: pbs-3; Y38A8.2; Y38A8.2.1; Y38A8.2.2; 2F244; CE07571; NM_062512; WBGene00003949; WP:CE07571 WormBase description: pbs-3 encodes a B-type subunit of the 26S proteasome's 20S protease core particle; by homology, PBS-3 is predicted to function in ATP/ubiquitin-dependent nonlysosomal protein degradation; loss of pbs-3 activity via large-scale RNAi screens indicates that, in C. elegans, PBS-3 is required for embryonic and germline development, movement, normal body coloration, and normal body morphology. WormBase CDS description: Peptidase
                                              
Member of lists (Publications lists):
                                              Golden et al 2004, N2 vs daf-2                                    
                                              different genes at , Golden et al 2004, N2 vs daf-2 age                            
                                              different gene, Golden et al 2004, N2 differentially                               
                                              expressed gen, McCarroll et al 2004  SFig5 conserved w/                            
                                              yeast, McCarroll et al 2004  SFig1-4 conserved w/                                  
                                              Drosoph, Reinke et al 2004, intrinsic, Reinke et al                                
                                              2004, wt vs glp-4 enriched genes, ViswanathanM et al                               
                                              2005  S2 sir-2.1 regulated