Jiang et al 2001 Fig4 Wnt signaling genes, 12 genes

Gene list file name:Jiang2001.Fig4_Wnt-signaling-genes.txt
Type of gene identifier:Cosmid name
Description:Jiang et al 2001 Fig4 Wnt signaling genes  
Organism:Caenorhabditis elegans (nematode)
Gene list type:Experimental

Gene name             Source Gene ID          Annotation                                                  Date       Added by    

B0336.1 wrm-1 P W All gene names: wrm-1; B0336.1; B0336.1.1; B0336.1.2; 3G815; CE26743; NM_065835; WBGene00006943; WP:CE26743
                                              
Member of lists (Publications lists):
                                              ViswanathanM et al 2005  S2 sir-2.1                               
                                              regulated, ViswanathanM et al 2005  S2 daf-16                                      
                                              Resveratrol                                                                        

C27A2.6 C27A2.6 P W All gene names: dsh-2; C27A2.6; 2F370; CE27097; NM_062536; WBGene00001102; WP:CE27097 WormBase description: dsh-2 encodes a protein containing a DIX domain, a DEP domain, and a PDZ domain that is required for embryonic viability and functions in Wnt pathway signaling between the embryonic blastomeres P2 and EMS with respect to endoderm specification and to orient the division axis of the EMS cell; expressed from the four-cell embryo stage, and is primarily associated with membranes.
                                              
Member of lists (Publications lists):
                                              Jiang et al 2001  Fig4 Wnt signaling                              
                                              genes, Reinke et al 2004, fem1 enriched genes, Reinke                              
                                              et al 2004, wt vs glp-4 enriched genes, Reinke et al                               
                                              2004, list of genes in cluster order, Reinke et al                                 
                                              2004, oogenesis enriched genes, Reinke et al 2004, wt                              
                                              herm vs wt male enriched gen, Reinke et al 2004, list                              
                                              of genes in cluster E, ViswanathanM et al 2005  S2                                 
                                              sir-2.1 regulated                                                                  

C54D1.6 bar-1 P W All gene names: bar-1; pvl-1; spy-1; C54D1.6; C54D1.6.1; C54D1.6.2; CE08973; NM_076805; WBGene00000238; WP:CE08973; XH786 WormBase description: bar-1 encodes a beta-catenin; during C. elegans development, BAR-1 likely functions as a transcriptional coactivator whose activity is required for Q neuroblast migration, P12 cell fate specification, and P3.p through P8.p vulval cell fate specification at two different stages of development; in specifying vulval cell fates, bar-1 interacts with Wnt and MAPK signaling pathways to regulate proper expression of the LIN-39 homeodomain transcription factor, overexpresion of which can partially rescue the bar-1 mutant phenotype; in yeast two-hybrid assays, BAR-1 interacts strongly with the POP-1/TCF transcription factor, and when fused to the Gal4 DNA binding domain, BAR-1 can function in yeast as a transcriptional coactivator; during larval development, BAR-1 expression begins in P3.p through P8.p at the late L1 stage and then disappears from these cells by the mid-L3 stage; BAR-1 is also expressed in P12, in the seam cells, and in cells of the somatic gonad; BAR-1 subcellular localization, assessed using an integrated transgene, reveals localization to the cytoplasm, nucleus, and cell junctions; genetic mosaic analyses indicate that, in P4.p and in P12, bar-1 acts cell autonomously to specify cell fates. WormBase CDS description: beta-catenin
                                              
Member of lists (Publications lists):
                                              Reinke et al 2004, list of genes in                               
                                              cluster order, Reinke et al 2004, list of genes in                                 
                                              cluster B                                                                          

E01A2.3 lin-44 P W All gene names: lin-44; E01A2.3; E01A2.G; 1E697; CE24870; CE36923; NM_058899; WBGene00003029; WP:CE24870; WP:CE36923 WormBase description: lin-44 encodes one of five C. elegans Wnt signaling ligands; during development, LIN-44 activity is required non-cell-autonomously for polarity specification of asymmetric cell divisions of the B, U, and F cells in the male, and the T cell in males and hermaphrodites; in addition, LIN-44 functions redundantly with MOM-2 and CWN-2 to pattern the P7.p lineage during vulval development; lin-44 expression begins at the 1.5-fold stage of embryogenesis in the posterior hypodermal cells hyp10 and hyp11; during later embryonic stages additional expression in hyp8 and hyp9 is detected; reporter fusions and in situ hybridization studies also reveal weak and inconsistent expression in the anchor cell of the somatic gonad.
                                              
Member of lists (Publications lists):
                                              ViswanathanM et al 2005  S2 sir-2.1                               
                                              regulated                                                                          

F38E1.7 mom-2 P W All gene names: mom-2; F38E1.7; 5I837; CE17806; NM_072753; WBGene00003395; WP:CE17806 WormBase description: mom-2 encodes a member of the Wnt family of secreted signaling glycoproteins that is required for induction of endodermal (gut) tissue in the 4-cell stage embryo; MOM-2, required in the inducing blastomere (P2) at the 4-cell stage, may be the ligand for MOM-5, a Frizzled homolog, thought to act in the receiving blastomere (EMS); MOM-2 genetically interacts in the same pathway as KIN-19, but parallel to APR-1; MOM-2 also may be a ligand for LIN-18, a Ryk homolog. WormBase CDS description: WNT family protein
                                              
Member of lists (Publications lists):
                                              Reinke et al 2004, fem1 enriched                                  
                                              genes, Reinke et al 2004, Fig2b shared gemlines, Reinke                            
                                              et al 2004, list of genes in cluster order, Reinke et                              
                                              al 2004, oogenesis enriched genes, Reinke et al 2004,                              
                                              wt vs glp-4 enriched genes, Reinke et al 2004, wt males                            
                                              vs glp4 male enriched , Reinke et al 2004, wt herm vs                              
                                              wt male enriched gen, Reinke et al 2004, list of genes                             
                                              in cluster E, ViswanathanM et al 2005  S2 sir-2.1                                  
                                              regulated                                                                          

K04G2.8 apr-1 P W All gene names: apr-1; K04G2.8; K04G2.8b.1; K04G2.8b.2; 1I631; CE06102; CE18016; NM_059816; WBGene00000156; WP:CE06102; WP:CE18016 WormBase description: The apr-1 gene encodes an ortholog of human APC (OMIM:175100, mutated in familial adenomatous polyposis) that is required for germline fertility, the control of homeodomain expression (CEH-13 and LIN-39) during embryogenesis and vulval development, and for the migration and elongation of hypodermal cells during embryo morphogenesis; APR-1 is thought to reside in adherens junctions, while also stimulating two beta-catenins in Wnt signalling (HMP-2 in migrating epithelial cells, and BAR-1 in the vulval precursor cells); however, APR-1 also binds PRY-1/axin, and with PRY-1 inhibits RAS-independent Wnt induction of LIN-39.
                                              
Member of lists (Publications lists):
                                              Reinke et al 2004, fem1 enriched                                  
                                              genes, Reinke et al 2004, wt vs glp-4 enriched genes,                              
                                              Reinke et al 2004, oogenesis enriched genes, Reinke et                             
                                              al 2004, wt herm vs wt male enriched gen, ViswanathanM                             
                                              et al 2005  S2 sir-2.1 regulated                                                   

K05C4.6 hmp-2 P W All gene names: hmp-2; K05C4.6; KO5C4.6; 1P333; CE19974; NM_061165; WBGene00001979; WP:CE19974 WormBase description: hmp-2 encodes a beta-catenin; HMP-2 activity is required during embryonic development for cell adhesion at adherens junctions, cell migration, and body morphogenesis; as a beta-catenin, HMP-2 likely functions solely as part of a cadherin-catenin complex, as in yeast two-hybrid assays, HMP-2 is the only C. elegans beta-catenin that binds HMP-1/alpha-catenin and HMR-1/cadherin; additionally, in the embryo, HMP-2 co-localizes to sites of epithelial cell contacts with HMP-1 and HMR-1/cadherin; however, despite its normal role in embryonic cell adhesion, HMP-2 can activate transcription and when overexpressed in vivo, can partially rescue vulval defects produced by loss of BAR-1/beta-catenin, suggesting that HMP-2 has retained the ability to interact with the Wnt signaling pathway. WormBase CDS description: Armadillo/beta-catenin-like repeats (4 domains)
                                              
Member of lists (Publications lists):
                                              McCarroll et al 2004  SFig5 conserved                             
                                              w/ yeast, McCarroll et al 2004  SFig1-4 conserved w/                               
                                              Drosoph, Reinke et al 2004, fem1 enriched genes, Reinke                            
                                              et al 2004, wt vs glp-4 enriched genes, Reinke et al                               
                                              2004, oogenesis enriched genes, Reinke et al 2004, wt                              
                                              herm vs wt male enriched gen, ViswanathanM et al 2005                              
                                              S2 sir-2.1 regulated                                                               

K10B4.6 wnt-1 P W All gene names: Wnt-1; cwn-1; K10B4.6; 2A422; CE12072; CE33421; WBGene00000857; WP:CE12072; WP:CE33421 WormBase description: cwn-1 encodes one of five C. elegans Wnt signaling ligands; although the precise developmental role of cwn-1 is not yet known, during embryogenesis cwn-1 likely functions as a downstream target of the PAL-1 homeodomain protein in the regulatory network that specifies cell fates in the C lineage that gives rise to ectodermal and muscle tissue; consistent with this role, loss of cwn-1 activity via RNAi results in rare larval tail defects that may result, in part, from abnormal morphogenesis of C lineage descendants; a cwn-1 reporter is expressed in C and D muscle cells, as well as in two posterior C ectodermal cells; cwn-1 mRNA is detectable at all developmental stages, with highest levels of expression seen in embryonic stages.
                                              
Member of lists (Publications lists):
                                              Baugh et al 2005, validated PAL-1                                 
                                              target genes, Baugh et al 2005, PAL-1 target genes                                 

T05C12.6 mig-5 P W All gene names: mig-5; T05C12.6; 2I474; CE02318; CE25100; CE28076; WBGene00003241; WP:CE02318; WP:CE25100; WP:CE28076 WormBase description: mig-5 encodes one of three C. elegans Dishevelled homologs; as part of both canonical and non-canonical Wnt signaling pathways, mig-5 activity is required maternally and embryonically for cell migration, cell fate specification, and proper spindle orientation in the early embryo; cells affected by mig-5 mutations include the distal tip cells (DTCs), the QL neuroblast descendants (QL.d), the vulval precursor cells, and the P12 ectoblast; in the early embryo, MIG-5 functions downstream of MOM-2/Wnt and MOM-1/Porc, and redundantly with two other Dishevelled homologs, DSH-1 and DSH-2, in a non-canonical Wnt pathway that specifies the endoderm cell fate and regulates mitotic spindle orientation in the EMS and ABar blastomeres; in posteriorly directed QL.d migrations, MIG-5 functions downstream of EGL-20/Wnt and upstream of PRY-1/Axin in a canonical Wnt pathway to positively regulate Wnt signaling and effect MAB-5 expression in QL.d; a mig-5::GFP fusion is reportedly expressed in many cells in the embryo, migrating DTCs, P cells, and the nerve ring. WormBase CDS description: presynaptic density protein (PSD-95) repeat-like domain
                                              
Member of lists (Publications lists):
                                              Reinke et al 2004, fem1 enriched                                  
                                              genes, Reinke et al 2004, wt vs glp-4 enriched genes,                              
                                              Reinke et al 2004, oogenesis enriched genes, Reinke et                             
                                              al 2004, wt herm vs wt male enriched gen, ViswanathanM                             
                                              et al 2005  S2 sir-2.1 regulated                                                   

T23D8.1 mom-5 P W All gene names: mom-5; T23D8.1; 1K545; CE14048; NM_060234; WBGene00003397; WP:CE14048 WormBase description: Drosophila tissue polarity protein like
                                              
Member of lists (Publications lists):
                                              McCarroll et al 2004  SFig1-4                                     
                                              conserved w/ Drosoph, Reinke et al 2004, fem1 enriched                             
                                              genes, Reinke et al 2004, list of genes in cluster                                 
                                              order, Reinke et al 2004, mixed oogenesis soma, Reinke                             
                                              et al 2004, list of genes in cluster E                                             

W08D2.1 egl-20 P W All gene names: egl-20; W08D2.1; 4K578; CE25152; NM_069353; WBGene00001188; WP:CE25152 WormBase description: egl-20 encodes a member of the WNT family of developmental signaling proteins that affects migration of QL and QR and their descendents; expressed in muscle and epidermal cells at the posterior of the worm. WormBase CDS description: WNT protein
                                              
Member of lists (Publications lists):
                                              ViswanathanM et al 2005  S2 sir-2.1                               
                                              regulated                                                                          

W10C8.2 pop-1 P W All gene names: pop-1; sys-2; W10C8.2; 1D392; CE26031; NM_058652; WBGene00004077; WP:CE26031 WormBase description: pop-1 encodes an HMG box-containing protein that is the sole C. elegans member of the TCF/LEF family of transcription factors; in C. elegans, POP-1 functions as a component of the canonical and noncanonical Wnt signaling pathways that are required for cell migrations and binary cell fate decisions associated with asymmetric cell division, respectively; in yeast two-hybrid assays, the POP-1 N-terminal beta-catenin binding domain interacts with BAR-1/beta-catenin as well as with the more divergent beta-catenin, SYS-1; when coexpressed with SYS-1, POP-1 is able to activate transcription from a promoter with TCF binding sites; during development, maternally provided POP-1 is first detected in the nuclei of maturing oocytes and then in nearly all cells of the early embryo; in sister blastomeres in the early embryo, POP-1 is detected at lower levels in posterior blastomeres, such as E and P3, than in corresponding anterior blastomeres, MS and C; in later developmental stages, POP-1 is detected in a subset of tissues including hypodermal seam cells, gonadal precursors, and the developing vulva; in the vulva, POP-1 also exhibits an asymmetric staining pattern, with sister cells showing high or low levels of POP-1 depending upon their orientation along the anterior/posterior axis of the vulva.
                                              
Member of lists (Publications lists):
                                              McCarroll et al 2004  SFig1-4                                     
                                              conserved w/ Drosoph, Reinke et al 2004, list of genes                             
                                              in cluster order, Reinke et al 2004, list of genes in                              
                                              cluster E