Lund et al 2002 Fig3B neuro-specific genes, 100 genes

Gene list file name:Lund2002_Aging_time_course.Fig3B_neuro.txt
Type of gene identifier:Cosmid name
Description:Lund et al 2002 Fig3B neuro-specific genes  
Organism:Caenorhabditis elegans (nematode)
Gene list type:Experimental

Gene name             Source Gene ID          Annotation                                                  Date       Added by    

AH6.4 sra-1 P W All gene names: sra-1; AH6.4; 2J806; CE01458; NM_063641; WBGene00005027; WP:CE01458 WormBase description: sra-1 encodes a predicted seven transmembrane receptor; expressed in the male SPD and SPV neurons. WormBase CDS description: 7TM chemoreceptor, sra family
AH6.6 sra-2 P W All gene names: sra-2; AH6.6; 2J819; CE01460; NM_063643; WBGene00005028; WP:CE01460 WormBase description: 7TM chemoreceptor, sra family
B0212.5 osm-9 P W All gene names: nss-2; osm-9; B0212.5; 4E316; CE20445; NM_067971; WBGene00003889; WP:CE20445 WormBase description: The osm-9 gene encodes a capsaicin receptor homolog involved in sensory responses to a subset of chemical stimuli and to ASH neuron-mediated osmotic and mechanical stimuli; OSM-9 is also involved in adaptation to volatile odorants and salts. WormBase CDS description: olfacory channel
                                              
Member of lists (Publications lists):
                                              McCarroll et al 2004  SFig1-4                                     
                                              conserved w/ Drosoph, Romagnolo et al 2002  Fig3b                                  
                                              signaling, ViswanathanM et al 2005  S2 daf-16                                      
                                              Resveratrol                                                                        

B0273.4 B0273.4 P W All gene names: unc-5; B0273.4; 4G260; CE16790; CE37693; NM_068421; NM_068422; WBGene00006745; WP:CE16790; WP:CE37693 WormBase description: unc-5 encodes a netrin receptor; unc-5 activity is required cell autonomously for dorsalward cell and pioneer motor axon migrations along the body wall that are essential for normal locomotion and gonad development; unc-5 mRNAs are expressed throughout the entire life cycle, with increasing levels seen as animals progess to adulthood. WormBase CDS description: axon guidance protein
                                              
Member of lists (Publications lists):
                                              Lund et al 2002  Fig3B neuro-specific                             
                                              genes                                                                              

B0348.3 B0348.3 P W All gene names: B0348.3; WBGene00043082
                                              
Member of lists (Publications lists):
                                              Lund et al 2002  Fig3B neuro-specific                             
                                              genes                                                                              

B0350.1 B0350.1 P W All gene names: B0350.1; WBGene00043083
                                              
Member of lists (Publications lists):
                                              Lund et al 2002  Fig3B neuro-specific                             
                                              genes, ViswanathanM et al 2005  S2 daf-16 Resveratrol                              

B0365.3 eat-6 P W All gene names: eat-6; spa-1; B0365.3; B0365.3.1; B0365.3.2; 5N608; CE07721; NM_073868; NaK/1; WBGene00001137; WP:CE07721 WormBase description: eat-6 encodes an ortholog of the alpha subunit of a sodium/potassium ATPase, which in turn affects Na+,K(+)-ATPase activity of membranes by affecting the level of the phosphorylated intermediate of the Na+,K(+)-ATPase; EAT-6 affects relaxation of the pharyngeal muscles, fertility (and thus affects feeding); EAT-6 also affects body length, life span, and ASE, ASI and ASJ axonal outgrowth. WormBase CDS description: Na(+)/K(+) ATPase alpha subunit
                                              
Member of lists (Publications lists):
                                              McCarroll et al 2004  SFig1-4                                     
                                              conserved w/ Drosoph, Reinke et al 2004, fem1 enriched                             
                                              genes, Reinke et al 2004, mixed oogenesis soma,                                    
                                              ViswanathanM et al 2005  S2 sir-2.1 regulated                                      

B0564.10 unc-30 P W All gene names: unc-30; B0564.10; 4N887; CE05183; CE36087; NM_070125; WBGene00006766; WP:CE05183; WP:CE36087 WormBase description: unc-30 encodes a paired-like homeodomain transcription factor orthologous to vertebrate Pitx homeodomain proteins, such as mouse Pitx2; UNC-30 controls the terminal differentiation of all 19 type D GABA-ergic motor neurons by directly regulating the expression of UNC-25/GAD and UNC-47/VGAT, which are responsible for GABA formation and secretion, respectively; UNC-30 is expressed most strongly in type D motor neurons during early L1 and L2 larval stages. WormBase CDS description: homeobox protein (otd subfamily)
                                              
Member of lists (Publications lists):
                                              McCarroll et al 2004  SFig1-4                                     
                                              conserved w/ Drosoph, Romagnolo et al 2002  Fig3b TF                               

C01G10.11 unc-76 P W All gene names: unc-76; C01G10.11; C01G10.11a.1; C01G10.11a.2; C01G10.11b.1; C01G10.11b.2; 5P559; CE39210; CE39211; NM_074311; WBGene00006808; WP:CE39210; WP:CE39211 WormBase description: UNC-76 protein
                                              
Member of lists (Publications lists):
                                              McCarroll et al 2004  SFig1-4                                     
                                              conserved w/ Drosoph                                                               

C02H7.3 aex-3 P W All gene names: aex-3; C02H7.3; CE16806; CE30850; NM_171618; WBGene00000086; WP:CE16806; WP:CE30850; XB370 WormBase description: The aex-3 gene encodes a guanine nucleotide exchange factor for the rab-3 GTPase that is orthologous to human MAP kinase activating protein containing death domain (MADD, OMIM:603584); AEX-3 is required for intracellular vesicle trafficking as well as synaptic vesicle release and interacts with CAB-1 and RAB-3 to regulate separate pathways for neural activities such as defecation and male mating, respectively; AEX-3 is also required for egg laying and locomotion; AEX-3 is expressed in nearly all neurons.
                                              
Member of lists (Publications lists):
                                              McCarroll et al 2004  SFig1-4                                     
                                              conserved w/ Drosoph, ViswanathanM et al 2005  S2                                  
                                              sir-2.1 regulated                                                                  

C03G5.7 flp-5 P W All gene names: flp-5; C03G5.7; CE06760; NM_077044; WBGene00001448; WP:CE06760; XJ149 WormBase description: flp-5 encodes a predicted FMRFamide-like peptide neurotransmitter that increases action potential frequency in the pharyngeal muscle when applied to the pharynx of dissected worms; expressed in the sensory neurons ASE and PVM.
C05E11.8 flp-12 P W All gene names: flp-12; C05E11.8; CE03938; NM_076388; WBGene00001455; WP:CE03938; XF210 WormBase description: flp-12 encodes a predicted FMRFamide-like peptide neurotransmitter that affects locomotion when injected into A. suum; expressed in the ASE and PVM sensory neurons.
                                              
Member of lists (Publications lists):
                                              ViswanathanM et al 2005  S2 sir-2.1                               
                                              regulated                                                                          

C06E1.4 glr-1 P W All gene names: glr-1; not-3; C06E1.4; 3J674; CE31407; NM_066486; WBGene00001612; WP:CE31407 WormBase description: glr-1 encodes an AMPA (non-NMDA)-type ionotropic glutamate receptor subunit; GLR-1 activity is required for mediating the behavioral response to light nose touch and the frequency with which animals change locomotory direction in response to sensory cues such as food; GLR-1 and GLR-2, a second AMPA-type ionotropic glutatmate receptor, can interact to form functional heteromeric channels; GLR-1 is expressed in motorneurons and interneurons, including four of the five pairs of command interneurons that are required for locomotory control; in the ventral nerve cord and nerve ring, GLR-1 localizes to perinuclear structures in cell bodies and to punctate structures that appear to be glutamatergic postsynaptic specializations; proper GLR-1 localization in the anterior ventral nerve cord of older larvae and adults requires activity of the class I PDZ protein LIN-10; GLR-1 is ubiquitinated in vivo and its abundance at postsynaptic elements, which may influence postsynaptic strength, is regulated by ubiquitination. WormBase CDS description: Glutamate receptor subunit
                                              
Member of lists (Publications lists):
                                              McCarroll et al 2004  SFig1-4                                     
                                              conserved w/ Drosoph, ViswanathanM et al 2005  S2                                  
                                              sir-2.1 regulated, ViswanathanM et al 2005  S2 daf-16                              
                                              Resveratrol                                                                        

C08B11.4 nrf-6 P W All gene names: nrf-6; C08B11.4; 2I320; CE27798; NM_063279; WBGene00003813; WP:CE27798 WormBase description: nrf-6 encodes a protein with 12 predicted transmembrane domains that is highly similar to NDG-4 and affects embryonic viability, yolk transport, locomotion, body morphology, and affects sensitivity to fluoxetine with respect to nose-contraction response in a common pathway with ndg-4 and nrf-5; expressed in the most anterior cells of the hypodermis and in the intestine and is required in the intestine for fluoxetine-induced nose contraction and yolk transport
                                              
Member of lists (Publications lists):
                                              McCarroll et al 2004  SFig1-4                                     
                                              conserved w/ Drosoph, Murphy et al 2003  Fig2 Class2                               
                                              shorten lifespan, Reinke et al 2004, list of genes in                              
                                              cluster order, Reinke et al 2004, list of genes in                                 
                                              cluster C, Reinke et al 2004, herm soma enriched genes,                            
                                              ViswanathanM et al 2005  S2 sir-2.1 regulated                                      

C15B12.5 gar-1 P W All gene names: acm-1; gar-1; C15B12.5; CE29666; CE29667; CE29668; WBGene00001517; WP:CE29666; WP:CE29667; WP:CE29668; XH98 WormBase description: gar-1 encodes a G-protein-linked acetylcholine receptor; though gar-1 is most closely related to muscarinic acetylcholine receptors (mAChR), it is pharmacologically distinct from them in its response to certain ligands; gar-1 gene transcripts are expressed at all developmental stages; the GAR-1-GFP fusion protein is expressed in some head neurons and in the PVM neuron; electrophysiological studies indicate that gar-1 couples to the inhibitory subunit of G proteins and not to Gs or to Go/Gq.
C16A11.1 gpa-11 P W All gene names: gpa-11; C16A11.1; 2E545; CE20515; NM_062347; WBGene00001673; WP:CE20515 WormBase description: gpa-11 encodes a member of the G protein alpha subunit family of heterotrimeric GTPases; it is expressed in ADL and ASH amphid neurons. WormBase CDS description: guanine nucleotide-binding protein
                                              
Member of lists (Publications lists):
                                              Reinke et al 2004, list of genes in                               
                                              cluster A, Reinke et al 2004, list of genes in cluster                             
                                              order                                                                              

C18D1.3 flp-4 P W All gene names: flp-4; C18D1.3; 2K345; CE01503; NM_063772; WBGene00001447; WP:CE01503 WormBase description: FMRFamide-like peptide
                                              
Member of lists (Publications lists):
                                              Wang et al 2003  S5 genes common to                               
                                              feeding ANOVA, Wang et al 2003  S3  genes pass one-way                             
                                              ANOVA                                                                              

C18H9.7 C18H9.7 P W All gene names: rpy-1; C18H9.7; 2G994; CE01807; NM_062964; WBGene00004507; WP:CE01807 WormBase description: rpy-1 is orthologous to the human gene 43KDA ACETYLCHOLINE RECEPTOR-ASSOCIATED PROTEIN (RAPSN; OMIM:601592), which when mutated leads to congenital myasthenic syndrome. WormBase CDS description: postsynaptic protein
                                              
Member of lists (Publications lists):
                                              Jones et al 2001  Dauer specific genes                            
                                              P<0.05, Lund et al 2002  Fig3B neuro-specific genes,                               
                                              Lund et al 2002  Aging time course Fig3A muscle,                                   
                                              McCarroll et al 2004  SFig1-4 conserved w/ Drosoph,                                
                                              Reinke et al 2004, list of genes in cluster A, Reinke                              
                                              et al 2004, list of genes in cluster order,                                        
                                              ViswanathanM et al 2005  S2 sir-2.1 regulated, Wang et                             
                                              al 2003  S3  genes pass one-way ANOVA, Wang et al 2003                             
                                              S8 SAGE genes in the dauer exit, Wang et al 2003  S7                               
                                              SAGE genes in the dataset, Wang et al 2003  S4 Early                               
                                              genes, Wang et al 2003  S4 genes pass two-wayANOVA P0                              

C26C6.2 goa-1 P W All gene names: goa-1; C26C6.2; 1I101; CE05311; NM_059707; WBGene00001648; WP:CE05311 WormBase description: The goa-1 gene encodes an ortholog of the heterotrimeric G protein alpha subunit Go (Go/Gi class) that affects normal locomotion, egg-laying, and male mating; it genetically interacts with the egl-30 pathway, and is expressed in all neurons and sex-specific muscles. WormBase CDS description: guanine nucleotide-binding protein
                                              
Member of lists (Publications lists):
                                              McCarroll et al 2004  SFig5 conserved                             
                                              w/ yeast, McCarroll et al 2004  SFig1-4 conserved w/                               
                                              Drosoph, Reinke et al 2004, fem1 enriched genes, Reinke                            
                                              et al 2004, mixed oogenesis soma, ViswanathanM et al                               
                                              2005  S2 sir-2.1 regulated                                                         

C34D1.3 odr-3 P W All gene names: odr-3; C34D1.3; 5N728; CE08571; NM_073889; WBGene00003850; WP:CE08571 WormBase description: guanine nucleotide-binding protein
C35C5.4 mig-2 P W All gene names: mig-2; C35C5.4; CE18544; NM_077530; WBGene00003239; WP:CE18544; XM167 WormBase description: mig-2 encodes a member of the Rho family of GTP-binding proteins that affects the migration of Q neuroblasts, HSN cells, and CAN cells as well as axon outgrowth and guidance; it is expressed in early embryos and expressed in adults in the vulva, distal tip cells of the gonad, and the sex myoblasts and their descendants. WormBase CDS description: RAS-related protein
                                              
Member of lists (Publications lists):
                                              McCarroll et al 2004  SFig1-4                                     
                                              conserved w/ Drosoph, ViswanathanM et al 2005  S2                                  
                                              sir-2.1 regulated                                                                  

C39E6.6 npr-1 P W All gene names: bor-1; npr-1; C39E6.6; CE06941; NM_076415; WBGene00003807; WP:CE06941; XF386 WormBase description: npr-1 encodes a predicted G protein-coupled neuropeptide receptor that is homologous to the mammalian neuropeptide Y (NPY) receptor (OMIM:162641) required for regulating anxiety, food consumption, and pain sensation; in C. elegans, NPR-1 is involved in ethological variations of social behavior such as social versus solitary feeding; NPR-1 also affects some aspect of UNC-6/netrin-mediated branching of motor neurons, as strong npr-1 mutations can suppress abnormal migration of ventral nerve cord neurons induced by overexpression of UNC-6 lacking domain C; NPR-1 is expressed predominantly in the nervous system, and particularly in the AQR, PQR, and URX neurons that are exposed to the body fluid. WormBase CDS description: G-protein coupled receptor
C40H5.5 ttx-3 P W All gene names: ttx-3; C40H5.5; CE27107; NM_077569; WBGene00006654; WP:CE27107; XM384 WormBase description: ttx-3 encodes a LIM homeodomain protein required for functions of the thermosensory interneuron AIY, including olfactory learning. WormBase CDS description: LIM domain containing proteins (2 domains), homeobox protein (lim subfamily)
C44B11.3 mec-12 P W All gene names: Alpha-tubulin; mec-12; tba-3; C44B11.3; C44B11.3.1; C44B11.3.2; 3E222; CE24843; NM_065262; WBGene00003175; WP:CE24843 WormBase description: mec-12 encodes a novel C. elegans alpha-tubulin that is unique amongst C. elegans alpha tubulins in that it may be subject to post-translational acetylation; MEC-12 is required for normal mechanosensory response to gentle touch, and specifically for formation of the 15-protofilament microtubule bundle present in the touch receptor neurons; mec-12 interacts genetically with mec-5, which encodes a unique C. elegans collagen secreted by the hypodermis; MEC-12 is highly expressed in the touch neurons as well as in several other neurons that do not contains the microfilament bundle, such as the ventral cord motorneurons. WormBase CDS description: alpha tubulin
                                              
Member of lists (Publications lists):
                                              McCarroll et al 2004  SFig1-4                                     
                                              conserved w/ Drosoph, Reinke et al 2004, list of genes                             
                                              in cluster order, Reinke et al 2004, wt herm vs wt herm                            
                                              enriched gen, Reinke et al 2004, list of genes in                                  
                                              cluster B, ViswanathanM et al 2005  S2 sir-2.1                                     
                                              regulated, Wang et al 2003  S3  genes pass one-way                                 
                                              ANOVA, Wang et al 2003  S4 Climbing, Wang et al 2003                               
                                              S4 genes pass two-wayANOVA P0                                                      

C48A7.1 egl-19 P W All gene names: eat-12; egl-19; pat-5; C48A7.1; 4I183; CE28820; CE31165; NM_171379; WBGene00001187; WP:CE28820; WP:CE31165 WormBase description: egl-19 encodes an ortholog of the alpha subunit of mammalian L-type calcium ion channels that affects muscle contraction in late embryonic morphogenesis, movement, egg-laying, mating and feeding; egl-19 is expressed in muscle cells and some neurons.
                                              
Member of lists (Publications lists):
                                              Reinke et al 2004, list of genes in                               
                                              cluster order, Reinke et al 2004, list of genes in                                 
                                              cluster B, ViswanathanM et al 2005  S2 sir-2.1                                     
                                              regulated                                                                          

C50H2.3 C50H2.3 P W All gene names: mec-9; C50H2.3; 5K388; CE05481; NM_073149; WBGene00003173; WP:CE05481 WormBase description: mec-9 encodes a predicted extracellular protein containing six EGF-like repeats,five Kunitz-type protease inhibitor domains, and a glutamic acid-rich region possibly involved in protein-protein interactions; mec-9 encodes two proteins, only one of which, MEC-9L, appears to be required for normal mechanosensory response to gentle touch and proper functioning of the touch receptor neurons; mec-9 interacts genetically with mec-5, which encodes a unique C. elegans collagen secreted by the hypodermis; MEC-9L is expressed and secreted by the touch receptor neurons. WormBase CDS description: mechanosensory protein (mec-9)
                                              
Member of lists (Publications lists):
                                              Lund et al 2002  Fig3B neuro-specific                             
                                              genes, ViswanathanM et al 2005  S2 sir-2.1 regulated                               

C52E12.2 unc-104 P W All gene names: klp-1; unc-104; C52E12.2; C52E12.2a.1; C52E12.2a.2; 2H299; CE30267; CE33041; NM_171017; WBGene00006831; WP:CE30267; WP:CE33041 WormBase description: The unc-104 gene encodes a kinesin-like motor protein homologous to human axonal transporter of synaptic vesicles (ATSV, OMIM: 601255), and is required for anterograde axonal transport of synaptic vesicles as well as differentiation of pre- and postsynaptic domains at inhibitory neuromuscular junctions; UNC-104 is expressed solely in neurons.
                                              
Member of lists (Publications lists):
                                              McCarroll et al 2004  SFig1-4                                     
                                              conserved w/ Drosoph, ViswanathanM et al 2005  S2                                  
                                              daf-16 Resveratrol                                                                 

C53B7.5 odr-10 P W All gene names: odr-10; C53B7.5; CE26361; NM_076756; WBGene00003856; WP:CE26361; XH484 WormBase description: The odr-10 gene encodes a member of the 7-transmembrane family of odorant receptors which affects chemotaxis to the volatile odorant diacetyl; it is expressed in two AWA neurons and, at low levels, in the CEP neurons. WormBase CDS description: chemoreceptor
                                              
Member of lists (Publications lists):
                                              ViswanathanM et al 2005  S2 daf-16                                
                                              Resveratrol, Wang et al 2003  S3  genes pass one-way                               
                                              ANOVA, Wang et al 2003  S4 Dauer Enriched, Wang et al                              
                                              2003  S4 genes pass two-wayANOVA P0                                                

C55H1.2 gpa-10 P W All gene names: gpa-10; C55H1.2; 5H334; CE27889; NM_072344; WBGene00001672; WP:CE27889 WormBase description: gpa-10 encodes a member of the G protein alpha subunit family of heterotrimeric GTPases; it is expressed in ADF, ASI, ASJ, ALN, CAN, LUA, and the spermatheca. WormBase CDS description: guanine nucleotide-binding protein
E02C12.5 gpa-3 P W All gene names: gpa-3; E02C12.5; 5J838; CE04314; NM_073024; WBGene00001665; WP:CE04314 WormBase description: gpa-3 encodes a member of the G protein alpha subunit family of heterotrimeric GTPases that affects dauer formation, water-soluble chemoattraction and chemoaversion, and volatile chemoattraction; it is expressed in amphid and phasmid neurons and some interneurons. WormBase CDS description: guanine nucleotide-binding protein
F01D4.6 mec-3 P W All gene names: mec-3; F01D4.6; 4L224; CE27422; CE34792; NM_069530; WBGene00003167; WP:CE27422; WP:CE34792 WormBase description: mec-3 encodes a founding member of the LIM (Lin-11, Isl-1, Mec-3) homeodomain family of transcriptional regulators; during C. elegans development, MEC-3 activity is required for proper differentiation and maturation of the mechanosensory neurons; MEC-3 is expressed in the mechanosensory neurons, where initiation of expression is dependent upon the UNC-86 homeodomain protein and maintenance of expression is dependent upon MEC-3 itself and mec-17.
                                              
Member of lists (Publications lists):
                                              Lund et al 2002  Fig4 Mount 15                                    

F07C6.1 pin-2 P W All gene names: pin-2; F07C6.1; 4N561; CE05562; NM_070039; WBGene00004030; WP:CE05562 WormBase description: LIM domains
                                              
Member of lists (Publications lists):
                                              ViswanathanM et al 2005  S2 daf-16                                
                                              Resveratrol                                                                        

F07D3.2 flp-6 P W All gene names: flp-6; F07D3.2; 5J953; CE29252; NM_073043; WBGene00001449; WP:CE29252 WormBase description: FMRFAMIDE-related peptide
                                              
Member of lists (Publications lists):
                                              Reinke et al 2004, IVb male soma                                  
                                              enriched genes, ViswanathanM et al 2005  S2 sir-2.1                                
                                              regulated, Wang et al 2003  S3  genes pass one-way                                 
                                              ANOVA, Wang et al 2003  S4 Dauer Enriched, Wang et al                              
                                              2003  S4 genes pass two-wayANOVA P0                                                

F09B9.2 unc-115 P W All gene names: unc-115; F09B9.2; CE02176; CE15759; NM_077301; WBGene00006839; WP:CE02176; WP:CE15759; XK771 WormBase description: unc-115 encodes a protein that binds actin filaments and that is required for RAS signalling and UNC-40/netrin activity during axon pathfinding. WormBase CDS description: LIM domains
                                              
Member of lists (Publications lists):
                                              McCarroll et al 2004  SFig1-4                                     
                                              conserved w/ Drosoph                                                               

F09E8.7 lev-1 P W All gene names: acr-1; lev-1; tmr-1; F09E8.7; 4N940; CE24888; NM_070133; WBGene00002974; WP:CE24888 WormBase description: lev-1 encodes an alpha subunit of nicotinic acetylcholine receptor (nAChR) which, when mutated, confers resistance to levamisole; LEV-1 is required for completely normal locomotion, and forms a cation channel when coexpressed with UNC-38 or UNC-63 and UNC-29; LEV-1 falls into the 'UNC-29' class of nAChR subunits, which includes UNC-29, ACR-2, and ACR-3. WormBase CDS description: acetylcholine receptor
                                              
Member of lists (Publications lists):
                                              Reinke et al 2004, list of genes in                               
                                              cluster A, Reinke et al 2004, list of genes in cluster                             
                                              order                                                                              

F11C7.1 F11C7.1 P W All gene names: F11C7.1; CE23644; WBGene00017375; WP:CE23644; XS45 WormBase description: ligand-gated ionic channel
                                              
Member of lists (Publications lists):
                                              Lund et al 2002  Fig3B neuro-specific                             
                                              genes, ViswanathanM et al 2005  S2 sir-2.1 regulated                               

F14F3.1 vab-3 P W All gene names: lin-20; mab-18; pax-6; vab-3; F14F3.1; CE24899; CE28216; CE28217; WBGene00006870; WP:CE24899; WP:CE28216; WP:CE28217; XL137 WormBase description: vab-3 encodes a homeodomain protein that is the C. elegans Pax-6 orthologue; during development, vab-3 activity is required for proper patterning of anterior (head) hypodermal cells; vab-3 effects head development, in part, through positively regulating transcription of ceh-32, a Six/sine oculis class homeobox gene coexpressed with vab-3 in head hypodermis.
                                              
Member of lists (Publications lists):
                                              McCarroll et al 2004  SFig1-4                                     
                                              conserved w/ Drosoph                                                               

F21F3.5 unc-38 P W All gene names: tmr-2; unc-38; F21F3.5; 1F466; CE24908; NM_059071; WBGene00006774; WP:CE24908 WormBase description: unc-38 encodes a nicotinic acetylcholine receptor (nAChR) alpha subunit; UNC-38 is required for normal locomotion and egg-laying, and functions as a subunit of a ligand-gated ion channel that likely mediates fast actions of acetylcholine at neuromuscular junctions and in the nervous system; when coexpressed with UNC-29 and LEV-1, non-alpha nAChR subunits, the resulting multimer can form levamisole-gated channels; UNC-38 is expressed postsynaptically in muscles and neurons where it colocalizes with TAX-6, and with ACR-8, ACR-12, and UNC-29, respectively. WormBase CDS description: ligand-gated ionic channel
                                              
Member of lists (Publications lists):
                                              McCarroll et al 2004  SFig1-4                                     
                                              conserved w/ Drosoph, Murphy et al 2003  Fig2 Class1                               
                                              elongate lifespan, Reinke et al 2004, list of genes in                             
                                              cluster A, Reinke et al 2004, list of genes in cluster                             
                                              order, ViswanathanM et al 2005  S2 sir-2.1 regulated                               

F23B2.5 flp-1 P W All gene names: flp-1; F23B2.5; 4J909; CE09585; CE32045; CE32046; NM_069191; NM_182277; NM_182278; WBGene00001444; WP:CE09585; WP:CE32045; WP:CE32046 WormBase description: flp-1 can encode up to seven distinct, yet highly similar, FMRFamide-related peptides (FaRPs), small neuromodulatory peptides that are characterized by a C-terminal Arg-Phe-amide motif; in C. elegans, FLP-1 peptides are required for regulation of several behaviors, including well-coordinated, sinusoidal movement and the transition between active and inactive states of egg-laying; receptors for the FLP-1 peptides have not yet been identified, but genetic studies indicate that FLP-1 peptides may act through G-protein coupled receptors; flp-1 mRNAs are detected at all developmental stages, and a FLP-1 translational reporter fusion detects expression in the anteriorly positioned neurons AVK, AVA, AVE, RIG, RMG, AIY, AIA, and M5
                                              
Member of lists (Publications lists):
                                              McCarroll et al 2004  SFig1-4                                     
                                              conserved w/ Drosoph, Murphy et al 2003  Fig2 Class1                               
                                              elongate lifespan, Reinke et al 2004, list of genes in                             
                                              cluster A, Reinke et al 2004, list of genes in cluster                             
                                              order, ViswanathanM et al 2005  S2 sir-2.1 regulated                               

F25G6.3 F25G6.3 P W All gene names: acr-16; F25G6.3; 5J43; CE09639; CE32878; Ce21; NM_072806; WBGene00000055; WP:CE09639; WP:CE32878 WormBase description: acr-16 encodes an alpha-7-like homomer-forming subunit of the nicotinic acetylcholine receptor (nAChR) superfamily orthologous to human nicotinic cholinergic receptor alpha 7 (CHRNA7; OMIM:118511; possibly associated with schizophrenia and juvenile myoclonic epilepsy); ACR-16 functions as a ligand-gated ion channel that probably regulates fast action of acetylcholine at neuromuscular junctions and in the nervous system; ACR-16 is active as a homomeric receptor and responds robustly to acetylcholine when expressed in Xenopus oocytes.
                                              
Member of lists (Publications lists):
                                              Lund et al 2002  Fig3B neuro-specific                             
                                              genes, Romagnolo et al 2002  Fig3b signaling, Wang et                              
                                              al 2003  S4 TransientList, Wang et al 2003  S3  genes                              
                                              pass one-way ANOVA, Wang et al 2003  S4 genes pass                                 
                                              two-wayANOVA P0                                                                    

F26C11.2 unc-4 P W All gene names: ceh-4; unc-4; F26C11.2; 2K188; CE01560; NM_063737; WBGene00006744; WP:CE01560 WormBase description: The unc-4 gene encodes a paired-class homeodomain protein with homologs in Drosophila and vertebrates; UNC-4 is required for establishing the identity of the A class motor neurons DA and VA, and is thus required for movement, axon guidance, and synapse formation; UNC-4 is negatively regulated by VAB-7, and UNC-4 activity requires UNC-37; unc-4 is expressed in the A-type motor neurons, DA and VA, the six VC motor neurons that innervate the vulval muscles, and the three SAB motor neurons; unc-4 is also expressed in the pharyngeal I5 motor neuron and the AVF neurons in the retrovesicular ganglion. WormBase CDS description: homeobox protein (otd subfamily)
                                              
Member of lists (Publications lists):
                                              McCarroll et al 2004  SFig1-4                                     
                                              conserved w/ Drosoph                                                               

F31F6.4 flp-8 P W All gene names: flp-8; F31F6.4; CE05776; CE29960; NM_171805; WBGene00001451; WP:CE05776; WP:CE29960; XP501 WormBase description: flp-8 encodes three copies of a FMRFamide-related short peptide neurotransmitter; although the FLP-8 peptide can increase pharyngeal action potential frequency, loss of FLP-8 function does not result in a mutant phenotype, suggesting that FLP-8 may function redundantly with other FMRFamide-like peptides in the nervous system; FLP-8 expression is detected in embryos and larval stages, but not in adults; FLP-8 is expressed in the sensory neurons ASEL/R, URXL/R, and PVM.
                                              
Member of lists (Publications lists):
                                              Reinke et al 2004, wt herm vs wt herm                             
                                              enriched gen, Reinke et al 2004, IVb male soma enriched                            
                                              genes                                                                              

F35H8.5 exc-7 P W All gene names: elr-1; exc-7; F35H8.5; 2J871; CE00983; NM_063656; WBGene00001368; WP:CE00983 WormBase description: exc-7 encodes an ELAV, an mRNA-binding protein homologous to Drosophila ELAV and human HuC/D (OMIM:603458, 168360, autoimmune antigens associated with paraneoplastic neurologic disorders); EXC-7 is required for formation of the tailspike and the excretory cell canals; exc-7 mutations enhance defects produced by mutations in exc-3, predicted to encode a peptidase, and sma-1, which encodes beta H-spectrin, a key component of the apical cytokeleton of polarized epithelial cells such as the excretory cell; in vitro, EXC-7 can bind the sma-1 mRNA 3' UTR, and thus is predicted to regulate SMA-1 expression in vivo; EXC-7 is expressed transiently in the excretory cell nucleus during mid-embryogenesis and during larval stages is detected in the pharynx, nerve ring, and nerve cord nuclei. WormBase CDS description: HUD
                                              
Member of lists (Publications lists):
                                              McCarroll et al 2004  SFig1-4                                     
                                              conserved w/ Drosoph, Reinke et al 2004, list of genes                             
                                              in cluster A, Reinke et al 2004, list of genes in                                  
                                              cluster order, ViswanathanM et al 2005  S2 daf-16                                  
                                              Resveratrol                                                                        

F36F2.5 tax-2 P W All gene names: nrf-7; tax-2; F36F2.5; 1J601; CE17780; NM_060026; WBGene00006525; WP:CE17780 WormBase description: tax-2 is orthologous to the human gene ROD PHOTORECEPTOR CNG-CHANNEL BETA SUBUNIT (CNGB1; OMIM:600724), which when mutated leads to disease. WormBase CDS description: cyclic nucleotide-gated channel
                                              
Member of lists (Publications lists):
                                              McCarroll et al 2004  SFig1-4                                     
                                              conserved w/ Drosoph, Reinke et al 2004, wt herm vs wt                             
                                              herm enriched gen, ViswanathanM et al 2005  S2 sir-2.1                             
                                              regulated, ViswanathanM et al 2005  S2 daf-16                                      
                                              Resveratrol                                                                        

F38E1.5 gpa-2 P W All gene names: gpa-2; F38E1.5; 5I853; CE04523; NM_072756; WBGene00001664; WP:CE04523 WormBase description: gpa-2 encodes a member of the G protein alpha subunit family of heterotrimeric GTPases that is involved in dauer formation and chemotaxis to water-soluble odorants; it is expressed in the phasmid neurons PHA and PHB, three pharyngeal neurons, one interneuron, three pairs of head neurons, and the anal sphincter muscle. WormBase CDS description: guanine nucleotide-binding protein
F38G1.1 che-2 P W All gene names: che-2; F38G1.1; F38G1.1.1; F38G1.1.2; CE25876; NM_075705; WBGene00000484; WP:CE25876; XB103 WormBase description: che-2 encodes a protein that contains G-protein beta-like WD-40 repeats that affects chemotaxis, dauer formation, and longevity; expressed in the cilia of most ciliated sensory neurons, some head neurons, and male tail rays. WormBase CDS description: G-beta-repeats
                                              
Member of lists (Publications lists):
                                              McCarroll et al 2004  SFig1-4                                     
                                              conserved w/ Drosoph                                                               

F42G9.9 F42G9.9 P W All gene names: ptl-1; tau-1; F42G9.9; F42G9.9a.1; F42G9.9a.2; F42G9.9b.1; F42G9.9b.2; F42G9.9c.1; F42G9.9c.2; F42G9.9d.1; F42G9.9d.2; 3B387; CE24967; CE28321; CE28322; CE30793; WBGene00004212; WP:CE24967; WP:CE28321; WP:CE28322; WP:CE30793 WormBase description: ptl-1 encodes a microtubule-binding protein that is homologous to members of the tau/MAP2/MAP4 subfamily of microtubule-associated proteins (OMIM:157140, abnormal aggregates of hyperphosphorylated tau are associated with several neurodegenerative disorders, including Alzheimer's disease, Pick's disease, and corticobasal degeneration); by homology, PTL-1 is predicted to promote microtubule assembly and stability, and to play a role in maintaining neuronal integrity and axonal transport; in vitro, bacterially expressed PTL-1 can bind microtubules; ptl-1 mRNA is expressed at highest levels in the embryo and early larval stages, while PTL-1 is detected in embryonic hypodermis and head neurons and then in the mechanosensory neurons, ALML, ALMR, AVM, PLML, and PLMR, in larvae and adults; as loss of ptl-1 function via mutation or large-scale RNAi screens does not result in any obvious abnormalities, the precise role of PTL-1 in C. elegans development and/or behavior is not yet known.
                                              
Member of lists (Publications lists):
                                              Lund et al 2002  Fig3B neuro-specific                             
                                              genes, ViswanathanM et al 2005  S2 sir-2.1 regulated,                              
                                              ViswanathanM et al 2005  S2 daf-16 Resveratrol                                     

F43G9.11 ces-1 P W All gene names: ces-1; F43G9.11; 1J211; CE17821; NM_059937; WBGene00000468; WP:CE17821 WormBase description: ces-1 encodes a C2H2-type zinc finger transcription factor that is a member of the Snail family of proteins that includes Drosophila Scratch, Snail, and Slug, and human SNAIL and SLUG; although the normal function of CES-1 is not fully understood, gain-of-function mutations indicate that CES-1 can function as a transcriptional repressor that blocks programmed cell death in specific neurons by inhibiting expression of the cell-death activator EGL-1; in regulating EGL-1 expression, CES-1 appears to antagonize the transcriptional activity of the bHLH proteins, HLH-2 and HLH-3; despite its cell-type specific role in apoptosis, CES-1 expression is reportedly detected in many embryonic nuclei from the 100-cell stage of embryogenesis through the beginning of morphogenesis, with some CES-1 expression remaining at later embryonic stages; genetic studies indicate that CES-1 is negatively regulated by the bZIP transcription factor CES-2, which can bind CES-1 upstream sequences in vitro and thus may directly regulate CES-1 transcription in vivo WormBase CDS description: Zinc finger, C2H2 type (5 domains)
                                              
Member of lists (Publications lists):
                                              Jones et al 2001  Non dauer genes                                 
                                              P<0.05, McCarroll et al 2004  SFig1-4 conserved w/                                 
                                              Drosoph, Reinke et al 2004, list of genes in cluster                               
                                              order, Romagnolo et al 2002  Fig3b TF                                              

F48C11.1 gpa-6 P W All gene names: gpa-6; F48C11.1; CE20829; NM_077788; WBGene00001668; WP:CE20829; XN811 WormBase description: gpa-6 encodes a member of the G protein alpha subunit family of heterotrimeric GTPases that affects response to water-soluble odorants; it is expressed in AWA amphid neurons, the PHB sensory cell, and (at low levels) in ASI amphid neurons. WormBase CDS description: guanine nucleotide-binding protein
                                              
Member of lists (Publications lists):
                                              ViswanathanM et al 2005  S2 daf-16                                
                                              Resveratrol                                                                        

F49E10.3 flp-7 P W All gene names: flp-7; F49E10.3; F49E10.3.1; F49E10.3.2; CE07264; NM_076584; WBGene00001450; WP:CE07264; XG505 WormBase description: flp-7 encodes an MVRFamide-containing peptide that, upon injection into A. suum, produces paralysis and loss of locomotory waveforms, increased body length, and decreased cAMP production.
                                              
Member of lists (Publications lists):
                                              Reinke et al 2004, wt herm vs wt herm                             
                                              enriched gen                                                                       

F53B1.7 gpa-5 P W All gene names: gpa-5; F53B1.7; CE04647; NM_075992; WBGene00001667; WP:CE04647; XC738 WormBase description: gpa-5 encodes a member of the G protein alpha subunit family of heterotrimeric GTPases; it is expressed in AWA, with faint expression in ASI. WormBase CDS description: guaninie nucleotide-binding protein
                                              
Member of lists (Publications lists):
                                              ViswanathanM et al 2005  S2 sir-2.1                               
                                              regulated                                                                          

F54B11.3 unc-84 P W All gene names: unc-84; F54B11.3; CE27761; CE28236; WBGene00006816; WP:CE27761; WP:CE28236; XO207 WormBase description: unc-84 encodes a transmembrane protein that contains a SUN domain with homology to S. pombe Sad1 and affects nuclear migration and anchoring of various cell types together with UNC-83 and ANC-1, thereby affecting coordinated locomotion, vulval formation, and egg laying; UNC-84 is localized to the nuclear envelope and requires LMN-1 for this localization, and it is expressed in the nuclear envelope of essentially all adult and embryonic cells.
                                              
Member of lists (Publications lists):
                                              ViswanathanM et al 2005  S2 sir-2.1                               
                                              regulated                                                                          

F55C7.7 unc-73 P W All gene names: unc-73; F55C7.7; 1E568; CE19464; CE19465; CE19466; CE19467; CE29398; CE36937; WBGene00006805; WP:CE19464; WP:CE19465; WP:CE19466; WP:CE19467; WP:CE29398; WP:CE36937 WormBase description: The unc-73 gene encodes a guanine nucleotide exchange factor (GNEF) similar to the Trio protein; UNC-73 is required for vulval morphogenesis, for the migration of QL, QR, and hypodermal P cells, the commisure outgrowth of D type motoneurons, and amphid axon outgrowth; UNC-73 has GNEF activity for both CED-10 and MIG-2 in vitro; the requirement for UNC-73 in P cell migration can be suppressed by transgenic overexpression of rho-1; UNC-73 activates several small GTPases: RHO-1 in P cell migration, and both CED-10 and MIG-2 in vulval morphogenesis, P cell migration, and axon outgrowth.
                                              
Member of lists (Publications lists):
                                              ViswanathanM et al 2005  S2 daf-16                                
                                              Resveratrol                                                                        

F56E3.4 fax-1 P W All gene names: fax-1; nhr-29; F56E3.4; CE28464; NM_076146; WBGene00001400; WP:CE28464; XD816 WormBase description: fax-1 encodes a predicted nuclear hormone receptor that contains two C4-type zinc fingers; FAX-1 is orthologous to the vertebrate photoreceptor-specific nuclear receptor (NR2E3 or PNR; OMIM:604485, mutated in enhanced S-cone syndrome and retinitis pigmentosa); FAX-1 is required for normal locomotion and for specification of neuronal identities, including pathfinding of the AVKR, AVKL, HSNL, and PVQL axons and expresion of the FMRFamide-like FLP-1 peptide neurotransmitter in AVKR and AVKL; FAX-1 is expressed in embryonic neurons, including the AVK interneurons, just prior to axon extension. WormBase CDS description: nuclear hormone receptor
                                              
Member of lists (Publications lists):
                                              McCarroll et al 2004  SFig1-4                                     
                                              conserved w/ Drosoph, ViswanathanM et al 2005  S2                                  
                                              sir-2.1 regulated                                                                  

K02G10.8 K02G10.8 P W All gene names: dnj-14; K02G10.8; CE04708; NM_076405; WBGene00001032; WP:CE04708; XF330 WormBase description: This gene encodes a protein containing a DnaJ ('J') domain.
                                              
Member of lists (Publications lists):
                                              Lund et al 2002  Fig3B neuro-specific                             
                                              genes, McCarroll et al 2004  SFig1-4 conserved w/                                  
                                              Drosoph, ViswanathanM et al 2005  S2 sir-2.1 regulated                             

K03B8.9 deg-3 P W All gene names: deg-3; K03B8.9; K03B8.9.1; K03B8.9.2; 5L894; CE06083; NM_073496; WBGene00000951; WP:CE06083 WormBase description: deg-3 encodes an alpha subunit of a nicotinic acetylcholine receptor (nAChR); originally defined by a gain-of-function mutation that results in neuronal degeneration and uncoordinated movement, DEG-3 can form heteromeric channels with a second alpha subunit, DES-2, and in vivo these channels appear to be required for chemosensation of choline; deg-3 and des-2 reside in an operon, and consistent with their role in metabolite chemosensation, are expressed in nonsynaptic regions such as the sensory endings of the IL2 chemosensory neurons; DEG-3 and DES-2 are also detected in the touch cell neurons, M1 head muscles, FLP and PVD sensory neurons, and the PVC interneuron; in subsets of these neurons, DEG-3 expression is not detectable in mec-3 or unc-86 mutant backgrounds. WormBase CDS description: nicotinic acetylcholine receptor
                                              
Member of lists (Publications lists):
                                              Reinke et al 2004, list of genes in                               
                                              cluster A, Reinke et al 2004, list of genes in cluster                             
                                              order, ViswanathanM et al 2005  S2 daf-16 Resveratrol                              

K10D3.2 unc-14 P W All gene names: unc-14; K10D3.2; 1H700; CE25055; NM_059617; WBGene00006753; WP:CE25055 WormBase description: The unc-14 gene encodes an activity required for both axonogenesis and sex myoblast migration.
                                              
Member of lists (Publications lists):
                                              Reinke et al 2004, list of genes in                               
                                              cluster A, Reinke et al 2004, list of genes in cluster                             
                                              order, Roy et al 2002  S3 muscle genes                                             

K11G12.2 acr-2 P W All gene names: acr-2; K11G12.2; CE07380; NM_076727; WBGene00000042; WP:CE07380; XH327 WormBase description: A homolog of a non-alpha type nicotinic acetylcholine receptor subunit that forms a functional channel when co-expressed with the unc-38 alpha subunit. WormBase CDS description: nicotinic acetylcholine receptor subunit
                                              
Member of lists (Publications lists):
                                              ViswanathanM et al 2005  S2 sir-2.1                               
                                              regulated                                                                          

K11G12.7 acr-3 P W All gene names: acr-3; K11G12.7; CE28345; NM_076728; WBGene00000043; WP:CE28345; XH331 WormBase description: acr-3 encodes a non-alpha subunit of the nicotinic acetylcholine receptor (nAChR) superfamily; ACR-3 functions as a ligand-gated ion channel that likely mediates fast actions of acetylcholine at neuromuscular junctions and in the nervous system; when coexpressed with UNC-38, an nAChR alpha subunit, the resulting hetero-oligomer can form levamisole-gated channels; ACR-3 is a member of the UNC-29-like group of nAChR subunits. WormBase CDS description: nicotinic acetylcholine receptor subunit
K12F2.2 vab-8 P W All gene names: klp-5; unc-107; vab-8; K12F2.2; 5M705; CE23870; CE31041; NM_073662; NM_073663; WBGene00006874; WP:CE23870; WP:CE31041 WormBase description: The vab-8 gene encodes a novel protein containing an atypical kinesin-like motor domain that is required for many posteriorly-directed cell migrations, as well as axonal outgrowth and pathfinding; vab-8 encodes two protein isoforms: VAB-8S, a novel protein expressed in migrating cells, and VAB-8L, which contains a kinesin-related domain, is expressed in neurons and functions in growth cone migrations; VAB-8 interacts with UNC-51, a serine-threonine kinase also required for axon outgrowth. WormBase CDS description: kinesin-like protein
M01D7.7 egl-30 P W All gene names: egl-30; gqa-1; M01D7.7; 1C313; CE12272; CE30556; NM_170806; WBGene00001196; WP:CE12272; WP:CE30556 WormBase description: The egl-30 gene encodes an ortholog of the heterotrimeric G protein alpha subunit Gq (Gq/G11 class) that affects viability, locomotion, egg laying, synaptic transmission, and pharyngeal pumping; it genetically interacts with the goa-1 pathway, and is probably expressed ubiquitously, with highest expression in excitable cells. WormBase CDS description: guanine nucleotide-binding protein
                                              
Member of lists (Publications lists):
                                              McCarroll et al 2004  SFig1-4                                     
                                              conserved w/ Drosoph, ViswanathanM et al 2005  S2                                  
                                              sir-2.1 regulated                                                                  

M02B7.3 osm-3 P W All gene names: caf-1; klp-2; osm-3; M02B7.3; M02B7.3a.1; M02B7.3a.2; 4E562; CE31567; CE31568; NM_171308; WBGene00003884; WP:CE31567; WP:CE31568 WormBase description: osm-3 encodes a homolog of the heavy chain subunit of heteromeric anterograde motor kinesins; OSM-3 is required for formation of the distal segment of amphid channel cilia, for responses to osmotic stimuli, for normal dauer formation, and for sensitivity to caffeine.
                                              
Member of lists (Publications lists):
                                              ViswanathanM et al 2005  S2 sir-2.1                               
                                              regulated                                                                          

M03A1.1 vab-1 P W All gene names: vab-1; M03A1.1; 2E879; CE25060; CE28617; NM_062405; NM_062406; WBGene00006868; WP:CE25060; WP:CE28617 WormBase description: tyrosine-protein kinase receptor
                                              
Member of lists (Publications lists):
                                              McCarroll et al 2004  SFig1-4                                     
                                              conserved w/ Drosoph, Reinke et al 2004, fem1 enriched                             
                                              genes, Reinke et al 2004, wt vs glp-4 enriched genes,                              
                                              Reinke et al 2004, oogenesis enriched genes,                                       
                                              ViswanathanM et al 2005  S2 sir-2.1 regulated,                                     
                                              ViswanathanM et al 2005  S2 daf-16 Resveratrol                                     

M142.1 unc-119 P W All gene names: unc-119; M142.1; 3L997; CE06203; NM_066998; WBGene00006843; WP:CE06203 WormBase description: unc-119 encodes a novel protein that is highly conserved amongst metazoans; unc-119 activity is required for proper development of the nervous system, including axonal branching and fasciculation, and hence, for normal movement, chemosensation, and feeding; unc-119 is expressed pan-neuronally beginning in the early embryo (~60 cells) and continuing through adulthood; although the molecular function of UNC-119 is not yet known, human UNC119, which can rescue C. elegans unc-119 mutant animals, is reported to function as a receptor-associated activator of signal transduction; thus, UNC-119 may be part of a signal transduction pathway that mediates axonal patterning in response to external developmental cues.
                                              
Member of lists (Publications lists):
                                              McCarroll et al 2004  SFig1-4                                     
                                              conserved w/ Drosoph, Romagnolo et al 2002  Fig3b                                  
                                              others, ViswanathanM et al 2005  S2 sir-2.1 regulated                              

M142.4 vab-7 P W All gene names: vab-7; M142.4; 3M15; CE12432; NM_067000; WBGene00006873; WP:CE12432 WormBase description: The vab-7 gene encodes an even-skipped-like homeodomain protein that is required for DB motoneuron identity and posterior DB axonal polarity. WormBase CDS description: homeobox protein (even-skipped subfamily)
                                              
Member of lists (Publications lists):
                                              Baugh et al 2005, validated PAL-1                                 
                                              target genes, Baugh et al 2005, PAL-1 target genes,                                
                                              McCarroll et al 2004  SFig1-4 conserved w/ Drosoph,                                
                                              ViswanathanM et al 2005  S2 daf-16 Resveratrol                                     

M7.1 let-70 P W All gene names: let-70; ubc-2; M7.1; 4L846; CE03482; NM_069664; WBGene00002344; WP:CE03482 WormBase description: let-70 encodes a class I E2 ubiquitin conjugating enzyme; let-70 was identified in screens for essential genes and phenotypic analyses indicate that loss of let-70 activity results in embryonic and larval lethality with defects in sarcomere assembly; purified LET-70 can stimulate the self-ubiquitylation activities of CHN-1 and UFD-2, E4 ubiquitin conjugation factors and, in addition, can stimulate the CHN-1- and UFD-2-dependent multiubiquitylation of UNC-45, a myosin-directed chaperone; in this manner, LET-70 may regulate UNC-45 degradation and myosin assembly; RNA blot analyses and a let-70-lacZ reporter fusion reveal that let-70 is abundantly expressed at all stages of development, including the dauer larval stage; strong staining is observed in most somatic tissues until adult stages, when expression generally becomes restricted to the nervous system. WormBase CDS description: ubiquitin-conjugating enzyme E2-17 KD
                                              
Member of lists (Publications lists):
                                              McCarroll et al 2004  SFig5 conserved                             
                                              w/ yeast, McCarroll et al 2004  SFig1-4 conserved w/                               
                                              Drosoph, Roy et al 2002  S3 muscle genes, ViswanathanM                             
                                              et al 2005  S2 sir-2.1 regulated                                                   

R07D5.1 unc-7 P W All gene names: unc-12; unc-124; unc-7; R07D5.1; CE06279; NM_078114; WBGene00006747; WP:CE06279; XP740 WormBase description: unc-7 encodes an innexin required for gap junction formation in invertebrates; UNC-7 is also required for normal locomotion, egg-laying, inhibition of feeding by tapping, avermectin sensitivity, and ivermectin sensitivity, as well as for the antagonism of UNC-79 and UNC-80 activity by volatile anesthetics; unc-7 is genetically required, and transcribed in, neurons rather than muscle cells, from larval stages L1 through L4; homologs of UNC-7 include Drosophila OGRE and SHAKING-B, as well as 24 C. elegans paralogs (including EAT-5, UNC-9, and INX-1 through INX-20); UNC-7 genetically interacts with UNC-124, and unc-7 mutants are phenotypically similar to unc-9 and unc-124 mutants; UNC-7 genetically interacts with AVR-14 and GLC-1 in the response to ivermectin. WormBase CDS description: unc-7 membrane protein
                                              
Member of lists (Publications lists):
                                              ViswanathanM et al 2005  S2 sir-2.1                               
                                              regulated                                                                          

R31.3 osm-6 P W All gene names: osm-6; R31.3; 5M406; CE27774; NM_171545; WBGene00003886; WP:CE27774 WormBase description: osm-6 males are defective in their response to hermaphrodite-derived diffusible cues. WormBase CDS description: N-acetyllactosamine synthase
                                              
Member of lists (Publications lists):
                                              McCarroll et al 2004  SFig1-4                                     
                                              conserved w/ Drosoph, ViswanathanM et al 2005  S2                                  
                                              daf-16 Resveratrol                                                                 

R53.3 egl-43 P W All gene names: egl-43; R53.3; 2K251; CE03572; CE03573; NM_063748; WBGene00001207; WP:CE03572; WP:CE03573 WormBase description: egl-43 encodes a zinc finger protein that affects HSN cell migration and development of the phasmid neurons; expressed in the HSN and phasmid neurons. WormBase CDS description: Zinc finger, C2H2 type (2 domains)
SSSD1.1 SSSD1.1 P W All gene names: igcm-2; SSSD1.1; CE36317; NM_076672; WBGene00020130; WP:CE36317; XG998 WormBase description: neural cell adhesion protein
                                              
Member of lists (Publications lists):
                                              Lund et al 2002  Fig3B neuro-specific                             
                                              genes, ViswanathanM et al 2005  S2 daf-16 Resveratrol                              

T01C8.7 mec-4 P W All gene names: mec-13; mec-4; T01C8.7; CE39109; NM_078311; WBGene00003168; WP:CE39109; XR418 WormBase description: mec-4 encodes an amiloride-sensitive Na+ channel protein (degenerin) required to sense gentle mechanical stimuli (e.g. touch) along the body wall; MEC-4 is paralogous to, and coexpressed with, MEC-10, in all six touch cell neurons where they form a heteromeric mechanotransduction channel.
                                              
Member of lists (Publications lists):
                                              ViswanathanM et al 2005  S2 daf-16                                
                                              Resveratrol                                                                        

T02C5.5 unc-2 P W All gene names: unc-2; T02C5.5; T02C5.5d.1; T02C5.5d.2; T02C5.5d.3; CE29459; CE31225; CE34591; CE34980; NM_171638; NM_171639; NM_171942; WBGene00006742; WP:CE29459; WP:CE31225; WP:CE34591; WP:CE34980; XD330 WormBase description: unc-2 encodes a calcium channel alpha subunit required for desensitization to dopamine, normal flexion and speed during movement, normally low sensitivity of whole animals to serotonin, and neuronal migrations promoted by humoral serotonin; UNC-2 is orthologous to human CACNA1A (OMIM:601011, mutated in familiar hemiplegic migraine or episodic ataxia 2) and to Drosophila CACOPHONY; UNC-2 is expressed primarily in motor neurons, several sensory neurons, and HSN and VC neurons controlling egg-laying.
                                              
Member of lists (Publications lists):
                                              McCarroll et al 2004  SFig1-4                                     
                                              conserved w/ Drosoph, Reinke et al 2004, list of genes                             
                                              in cluster A, Reinke et al 2004, list of genes in                                  
                                              cluster order                                                                      

T06C10.4 flp-10 P W All gene names: flp-10; T06C10.4; T06C10.4.1; T06C10.4.2; 4I635; CE04902; NM_068905; WBGene00001453; WP:CE04902
                                              
Member of lists (Publications lists):
                                              ViswanathanM et al 2005  S2 sir-2.1                               
                                              regulated, ViswanathanM et al 2005  S2 daf-16                                      
                                              Resveratrol                                                                        

T07A9.7 gpa-4 P W All gene names: gpa-4; T07A9.7; 4B157; CE31599; NM_067520; WBGene00001666; WP:CE31599 WormBase description: gpa-4 encodes a member of the G protein alpha subunit family of heterotrimeric GTPases; it is expressed in ASI. WormBase CDS description: guanine nucleotide-binding protein
                                              
Member of lists (Publications lists):
                                              ViswanathanM et al 2005  S2 sir-2.1                               
                                              regulated                                                                          

T08G11.5 unc-29 P W All gene names: tmr-4; unc-21; unc-29; unc-56; T08G11.5; 1J474; CE13451; NM_059998; WBGene00006765; WP:CE13451 WormBase description: unc-29 encodes an non-alpha subunit of the nicotinic acetylcholine receptor (nAChR) superfamily; UNC-29 is required for normal locomotion and egg-laying, and functions as a subunit of a ligand-gated ion channel that likely mediates fast actions of acetylcholine at neuromuscular junctions and in the nervous system; when coexpressed with LEV-1, a non-alpha nAChR subunit, and UNC-38 or UNC-63, alpha AChR subunits, the resulting multimer can form levamisole-gated channels; UNC-29 is expressed in body wall muscle. WormBase CDS description: acetylcholine receptor, beta precursor
                                              
Member of lists (Publications lists):
                                              McCarroll et al 2004  SFig1-4                                     
                                              conserved w/ Drosoph, Reinke et al 2004, mixed sperm                               
                                              soma, Reinke et al 2004, fem3 enriched genes                                       

T09A12.3 T09A12.3 P W All gene names: ocr-2; T09A12.3; 4I978; CE17232; NM_068979; WBGene00003839; WP:CE17232 WormBase description: ocr-2 encodes a TRPV (transient receptor potential channel, vanilloid subfamily) ion channel; OCR-2 activity is required for several types of sensory transduction including olfaction, osmosensation, mechanosensation, and chemosensation; an OCR-2 fusion protein is expressed in sensory cilia and requires the OSM-9 TRPV channel protein for proper localization; likewise, OSM-9 requires OCR-2 for its cilial localization.
                                              
Member of lists (Publications lists):
                                              Lund et al 2002  Fig3B neuro-specific                             
                                              genes                                                                              

T18D3.2 odr-7 P W All gene names: odr-7; T18D3.2; CE03663; NM_077688; WBGene00003854; WP:CE03663; XN78 WormBase description: The odr-7 gene encodes an olfactory specific member of the nuclear receptor superfamily that affects chemotaxis to some volatile odorants and the cell fate of the AWA neuron; it is expressed in AWA neurons. WormBase CDS description: Zinc finger, C4 type (two domains)
T19B4.6 T19B4.6 P W All gene names: T19B4.6; WBGene00043506
                                              
Member of lists (Publications lists):
                                              Lund et al 2002  Fig3B neuro-specific                             
                                              genes                                                                              

T19C4.6 gpa-1 P W All gene names: gpa-1; T19C4.6; 5L656; CE06470; NM_073439; WBGene00001663; WP:CE06470 WormBase description: gpa-1 encodes a member of the G protein alpha subunit family of heterotrimeric GTPases that is involved in chemotaxis to water-soluble odorants; it is expressed in sensory neurons and in the spicule and phasmid neurons of the male tail. WormBase CDS description: guanine nucleotide-binding protein
T20G5.6 unc-47 P W All gene names: unc-47; T20G5.6; 3L274; CE25119; NM_066854; WBGene00006783; WP:CE25119 WormBase description: unc-47 encodes a novel transmembrane vesicular GABA transporter; UNC-47 and UNC-46, a predicted novel transmembrane protein, are required in GABAergic neurons for all GABA neurotransmission, specifically for loading of GABA into synaptic vesicles, where UNC-47 is localized; UNC-47 is required for the localization of UNC-46, and when overexpressed can rescue unc-46 mutant animals; UNC-47 expression in type D neurons is transcriptionally regulated by the UNC-30 homeodomain protein.
                                              
Member of lists (Publications lists):
                                              McCarroll et al 2004  SFig1-4                                     
                                              conserved w/ Drosoph, ViswanathanM et al 2005  S2                                  
                                              sir-2.1 regulated, ViswanathanM et al 2005  S2 daf-16                              
                                              Resveratrol                                                                        

T21C12.1 unc-49 P W All gene names: unc-49; unc-49A; unc-49B; unc-49C; T21C12.1; T21C12.1c.1; T21C12.1c.2; 3L621; CE02346; CE28082; CE28083; CE28084; CE28085; CE28086; CE35949; WBGene00006784; WP:CE02346; WP:CE28082; WP:CE28083; WP:CE28084; WP:CE28085; WP:CE28086; WP:CE35949 WormBase description: gamma-aminobutyric-acid receptor
                                              
Member of lists (Publications lists):
                                              McCarroll et al 2004  SFig1-4                                     
                                              conserved w/ Drosoph, Roy et al 2002  S2                                           
                                              positivecontrol L1 muscle, ViswanathanM et al 2005  S2                             
                                              sir-2.1 regulated                                                                  

T23G5.5 dat-1 P W All gene names: dat-1; T23G5.5; 3K335; CE25124; NM_066642; WBGene00000934; WP:CE25124 WormBase description: dat-1 is orthologous to the human gene NOREPINEPHRINE TRANSPORTER (SLC6A2; OMIM:163970), which when mutated leads to disease. WormBase CDS description: sodium:neurotransmitter symporter
                                              
Member of lists (Publications lists):
                                              Link et al 2003  T2 Abeta induced,                                
                                              McCarroll et al 2004  SFig1-4 conserved w/ Drosoph,                                
                                              Portman et al 2004 T1 10 previously-known ray gene,                                
                                              ViswanathanM et al 2005  S2 sir-2.1 regulated,                                     
                                              ViswanathanM et al 2005  S2 daf-16 Resveratrol                                     

T26H10.1 T26H10.1 P W All gene names: acr-4; des-2; T26H10.1; CE21208; NM_073497; WBGene00000955; WP:CE21208 WormBase description: des-2 encodes an alpha subunit of nicotinic acetylcholine receptor (nAChR), predicted to be a ligand-gated ion channel regulating the fast action of acetylcholine at neuromuscular junctions and in the nervous system; DES-2 is coexpressed with and genetically interacts with DEG-3, which which it probably forms heteromultimers, and DES-2 falls into the 'DEG-3' class of nAChR subunits, probably unique to nematodes, which includes DEG-3, ACR-5, ACR-17, ACR-18 ACR-20, and ACR-23. WormBase CDS description: nicotinic acetylcholine receptor
                                              
Member of lists (Publications lists):
                                              Lund et al 2002  Fig3B neuro-specific                             
                                              genes, Romagnolo et al 2002  Fig3b signaling                                       

W01C8.6 cat-1 P W All gene names: cat-1; W01C8.6; CE35792; CE38560; WBGene00000295; WP:CE35792; WP:CE38560; XG324 WormBase description: cat-1 encodes a synaptic vesicular monoamine transporter required for the presence of dopamine and serotonin in nerve terminals, for the normal slowing of worms on a bacterial lawn (versus clean agar), for faster pharyngeal pumping on food, and for a normally (high) rate of egg-laying.
                                              
Member of lists (Publications lists):
                                              McCarroll et al 2004  SFig1-4                                     
                                              conserved w/ Drosoph, Reinke et al 2004, wt herm vs wt                             
                                              herm enriched gen                                                                  

W03G9.1 W03G9.1 P W All gene names: snf-1; W03G9.1; W03G9.1.1; W03G9.1.2; 1F551; CE30701; NM_059090; WBGene00004900; WP:CE30701 WormBase description: neurotransmitter transporter
                                              
Member of lists (Publications lists):
                                              Lund et al 2002  Fig3B neuro-specific                             
                                              genes                                                                              

W07E11.3 flp-2 P W All gene names: flp-2; flp-2a; flp-2b; W07E11.3; CE02374; CE28258; WBGene00001445; WP:CE02374; WP:CE28258; XK712 WormBase description: flp-2 encodes a predicted FMRFamide-like peptide neurotransmitter; expressed in the pharyngeal neuron I5.
                                              
Member of lists (Publications lists):
                                              Wang et al 2003  S3  genes pass                                   
                                              one-way ANOVA, Wang et al 2003  S4 Dauer Enriched, Wang                            
                                              et al 2003  S4 genes pass two-wayANOVA P0                                          

Y102E9.1 odr-4 P W All gene names: odr-4; Y102E9.1; Y102E9.1a.1; Y102E9.1a.2; Y102E9.1a.3; Y102E9.1a.4; 3H823; CE28101; CE32953; CE32954; NM_066076; WBGene00003851; WP:CE28101; WP:CE32953; WP:CE32954 WormBase description: odr-4 encodes a novel type II membrane protein required for the localization of a subset of seven transmembrane domain odorant receptors, including ODR-10, to the cilia of olfactory neurons, it affects response to a subset of AWA- and AWC- mediated olfactory responses, and is required for social feeding of npr-1 mutant animals; expressed in 12 pairs of chemosensory neurons.
                                              
Member of lists (Publications lists):
                                              Reinke et al 2004, wt herm vs wt male                             
                                              enriched gen, ViswanathanM et al 2005  S2 sir-2.1                                  
                                              regulated                                                                          

Y16B4A.1 unc-3 P W All gene names: unc-3; Y16B4A.1; CE29366; NM_078052; WBGene00006743; WP:CE29366; XP401 WormBase description: The unc-3 gene encodes a protein with homology to immunoglobulin (Ig) domain-containing transcription factors such as OLF-1 or SU(H). WormBase CDS description: transcription factor OLF-1 like
                                              
Member of lists (Publications lists):
                                              McCarroll et al 2004  SFig1-4                                     
                                              conserved w/ Drosoph, ViswanathanM et al 2005  S2                                  
                                              sir-2.1 regulated                                                                  

Y37D8A.23 unc-25 P W All gene names: unc-25; Y37D8A.23; 3O37; CE20226; CE31832; CE32012; NM_067288; WBGene00006762; WP:CE20226; WP:CE31832; WP:CE32012 WormBase description: Pyridoxal-dependent decarboxylase conserved domain
                                              
Member of lists (Publications lists):
                                              McCarroll et al 2004  SFig1-4                                     
                                              conserved w/ Drosoph, Reinke et al 2004, list of genes                             
                                              in cluster A, Reinke et al 2004, list of genes in                                  
                                              cluster order                                                                      

Y48B6A.8 ace-3 P W All gene names: ace-3; Y48B6A.8; 2O499; CE28131; NM_064562; WBGene00000037; WP:CE28131 WormBase description: ace-3 encodes one of four C. elegans acetylcholinesterases (AChE); ACE-3 represents ~5% of the total AChE activity in C. elegans and in vitro, hydrolyzes acetylthio-, butyrylthio-, and propionylthiocholine substrates with equal efficiency; although loss-of-function mutations in ace-3 result in no obvious defects, animals doubly mutant with ace-1 or ace-2 have slight defects in backward locomotion and animals triply mutant for ace-1, -2, and -3 arrest as unhatched, yet fully developed, embryos; ace-3 is the downstream gene in an operon with a fourth AChE-encoding gene, ace-4, and transcriptional reporter fusions with ace-4 upstream sequences direct expression in pharyngeal muscles pm3, 4, 5, and 7, the two CAN (canal associated neuron) cells, midbody dorsal body wall muscles in larvae, and several neurons in the head and anal ganglion
                                              
Member of lists (Publications lists):
                                              ViswanathanM et al 2005  S2 sir-2.1                               
                                              regulated, ViswanathanM et al 2005  S2 daf-16                                      
                                              Resveratrol                                                                        

Y54E5B.1 smp-1 P W All gene names: smp-1; Y54E5B.1; Y54E5B.1b.1; Y54E5B.1b.2; 1P407; CE19225; CE29065; NM_061181; WBGene00004889; WP:CE19225; WP:CE29065; cesema
                                              
Member of lists (Publications lists):
                                              McCarroll et al 2004  SFig1-4                                     
                                              conserved w/ Drosoph                                                               

ZC64.4 lim-4 P W All gene names: lim-4; nss-1; ZC64.4; CE25675; NM_076268; WBGene00002987; WP:CE25675; XE490 WormBase description: lim-4 encodes a LIM homeodomain protein homologous to murine Lhx6 and L3/Lhx7, and to Drosophila ARROWHEAD; LIM-4 is required for differentiation of AWB chemosensory neurons, for several but not all aspects of RID motor neuron differentiation, expression of ser-2, repulsion from chemosensory repellants, SAA neurite outgrowth, and normal locomotion and head foraging; lim-4 is expressed in AWB, RID, RIV, RMDL, RMDR, RMEV, four SAA neurons, and four SIA neurons. WormBase CDS description: LIM-homeodomain
                                              
Member of lists (Publications lists):
                                              McCarroll et al 2004  SFig1-4                                     
                                              conserved w/ Drosoph, ViswanathanM et al 2005  S2                                  
                                              daf-16 Resveratrol, Wang et al 2003  S6 removed genes                              
                                              of contamination                                                                   

ZC84.2 tax-4 P W All gene names: tax-4; ZC84.2; 3K275; CE27352; NM_066632; WBGene00006526; WP:CE27352 WormBase description: tax-4 is orthologous to the human gene ROD PHOTORECEPTOR CGMP-GATED CHANNEL (CNGA1; OMIM:123825), which when mutated leads to disease. WormBase CDS description: Cyclic-nucleotide-gated olfactory channel
                                              
Member of lists (Publications lists):
                                              McCarroll et al 2004  SFig1-4                                     
                                              conserved w/ Drosoph                                                               

ZK1010.9 ZK1010.9 P W All gene names: snf-7; ZK1010.9; 3O99; CE23490; NM_067301; WBGene00004906; WP:CE23490 WormBase description: Sodium:neurotransmitter symporter
                                              
Member of lists (Publications lists):
                                              Lund et al 2002  Fig1 aging-regulated                             
                                              genes, Lund et al 2002  Fig3B neuro-specific genes                                 

ZK1058.2 pat-3 P W All gene names: epi-2; pat-3; ZK1058.2; ZK1058.2.1; ZK1058.2.2; 3F0; CE01102; INTB/1; NM_065386; WBGene00003930; WP:CE01102 WormBase description: beta integrin
                                              
Member of lists (Publications lists):
                                              McCarroll et al 2004  SFig1-4                                     
                                              conserved w/ Drosoph, Reinke et al 2004, fem1 enriched                             
                                              genes, Reinke et al 2004, mixed oogenesis soma,                                    
                                              ViswanathanM et al 2005  S2 sir-2.1 regulated                                      

ZK377.3 ZK377.3 P W All gene names: ZK377.3; WBGene00043962
                                              
Member of lists (Publications lists):
                                              Lund et al 2002  Fig3B neuro-specific                             
                                              genes                                                                              

ZK512.6 eat-4 P W All gene names: eat-4; not-1; ZK512.6; 3K231; CE01109; NM_066622; WBGene00001135; WP:CE01109 WormBase description: eat-4 encodes an ortholog of the mammalian BNPI vesicular glutamate transporter that affects chemotaxis, feeding, foraging and thermotaxis; eat-4 is expressed in specific neurons, including M3L and M3R which are known to be glutamatergic. WormBase CDS description: Sodium/phosphate cotransporter
                                              
Member of lists (Publications lists):
                                              McCarroll et al 2004  SFig1-4                                     
                                              conserved w/ Drosoph                                                               

ZK524.2 unc-13 P W All gene names: unc-13; ZK524.2; 1I29; CE15371; CE34624; CE34625; CE34626; NM_059692; WBGene00006752; WP:CE15371; WP:CE34624; WP:CE34625; WP:CE34626 WormBase description: unc-13 encodes at least five protein isoforms that regulate neurotransmitter release by altering the conformation of syntaxin; UNC-13 proteins are required for normal pharyngeal pumping and thrashing in liquid, normally short lifespan, normally large brood sizes, and full adult body sizes; UNC-13 proteins have orthologs in vertebrates and Drosophila; UNC-13 proteins are complex, with multiple C2, phorbol ester-binding, and DUF1041 domains; UNC-13 protein form is localized to most or all synapses; many of the unc-13 mutant alleles with viable phenotypes are transcript-specific, while homozygotes with an unc-13 null (deletion) allele die as paralyzed first-stage larvae.
                                              
Member of lists (Publications lists):
                                              ViswanathanM et al 2005  S2 sir-2.1                               
                                              regulated                                                                          

ZK829.10 ZK829.10 P W All gene names: snf-8; ZK829.10; 4M730; CE24742; NM_069870; WBGene00004907; WP:CE24742 WormBase description: sodium-dependent neurotransmitter symporter like
                                              
Member of lists (Publications lists):
                                              Lund et al 2002  Fig3B neuro-specific                             
                                              genes                                                                              

ZK897.1 unc-31 P W All gene names: egl-22; unc-31; ZK897.1; 4N551; CE36419; NM_070036; WBGene00006767; WP:CE36419 WormBase description: unc-31 encodes a pleckstrin homology (PH) domain-containing protein orthologous to human calcium-dependent activator protein for secretion (CADPS, OMIM:604667); UNC-31 functions in post-docking calcium-regulated dense-core vesicle fusion that is required for egg laying, locomotion, pharyngeal pumping, and recovery from the dauer larval stage; in addition, UNC-31 functions in the insulin receptor signaling pathway that regulates adult life span where it may control Ca[2+]-regulated secretion of an insulin-like ligand. WormBase CDS description: PH (pleckstrin homology) domain
                                              
Member of lists (Publications lists):
                                              McCarroll et al 2004  SFig1-4                                     
                                              conserved w/ Drosoph, ViswanathanM et al 2005  S2                                  
                                              sir-2.1 regulated