Zhang et al. 2002, Fig2b overexpressed in mec-3MT, 25 genes

Gene list file name:Zhang2002.Fig2b_25overexpressed_in_mec-3MT.txt
Type of gene identifier:Cosmid name
Description:Zhang et al 2002 Fig2b 25 genes overexpressed in mec-3MT  
Organism:Caenorhabditis elegans (nematode)
Gene list type:Experimental

Gene name             Source Gene ID          Annotation                                                  Date       Added by    

C44B11.3 mec-12 P W All gene names: Alpha-tubulin; mec-12; tba-3; C44B11.3; C44B11.3.1; C44B11.3.2; 3E222; CE24843; NM_065262; WBGene00003175; WP:CE24843 WormBase description: mec-12 encodes a novel C. elegans alpha-tubulin that is unique amongst C. elegans alpha tubulins in that it may be subject to post-translational acetylation; MEC-12 is required for normal mechanosensory response to gentle touch, and specifically for formation of the 15-protofilament microtubule bundle present in the touch receptor neurons; mec-12 interacts genetically with mec-5, which encodes a unique C. elegans collagen secreted by the hypodermis; MEC-12 is highly expressed in the touch neurons as well as in several other neurons that do not contains the microfilament bundle, such as the ventral cord motorneurons. WormBase CDS description: alpha tubulin
                                              
Member of lists (Publications lists):
                                              McCarroll et al 2004  SFig1-4                                     
                                              conserved w/ Drosoph, Reinke et al 2004, list of genes                             
                                              in cluster order, Reinke et al 2004, wt herm vs wt herm                            
                                              enriched gen, Reinke et al 2004, list of genes in                                  
                                              cluster B, ViswanathanM et al 2005  S2 sir-2.1                                     
                                              regulated, Wang et al 2003  S3  genes pass one-way                                 
                                              ANOVA, Wang et al 2003  S4 Climbing, Wang et al 2003                               
                                              S4 genes pass two-wayANOVA P0                                                      

C52B9.9 mec-18 P W All gene names: mec-18; C52B9.9; CE16940; NM_076330; WBGene00003179; WP:CE16940; XE890 WormBase description: mec-18 encodes a protein similar to firefly luciferase and plant protein 4-coumarate coA ligase; mec-18 is involved in sensory mechanotransduction; genetic interactions with other mec genes suggest that mec-18 maybe involved in negative regulation of the degenerin channel in the touch receptor neurons; mec-18 is expressed exclusively in the touch cells. WormBase CDS description: AMP-binding protein
                                              
Member of lists (Publications lists):
                                              ViswanathanM et al 2005  S2 sir-2.1                               
                                              regulated, ViswanathanM et al 2005  S2 daf-16                                      
                                              Resveratrol                                                                        

CCT-2 cct-2 P W All gene names: CCT-2; NM_171985; WBGene00000378
D2007.2 D2007.2 P W All gene names: D2007.2; 3J241; CE00127; WBGene00017042; WP:CE00127 WormBase description: D2007.2 is orthologous to the human gene TRANSKETOLASE (WERNICKE-KORSAKOFF SYNDROME) (TNF; OMIM:606781), which when mutated leads to disease.
                                              
Member of lists (Publications lists):
                                              Wang et al 2003  S5 genes common to                               
                                              feeding ANOVA, Wang et al 2003  S3  genes pass one-way                             
                                              ANOVA, Zhang et al 2002, T1 mec-3 dependent genes,                                 
                                              Zhang et al. 2002, Fig2b overexpressed in mec-3MT                                  

F01D4.6 mec-3 P W All gene names: mec-3; F01D4.6; 4L224; CE27422; CE34792; NM_069530; WBGene00003167; WP:CE27422; WP:CE34792 WormBase description: mec-3 encodes a founding member of the LIM (Lin-11, Isl-1, Mec-3) homeodomain family of transcriptional regulators; during C. elegans development, MEC-3 activity is required for proper differentiation and maturation of the mechanosensory neurons; MEC-3 is expressed in the mechanosensory neurons, where initiation of expression is dependent upon the UNC-86 homeodomain protein and maintenance of expression is dependent upon MEC-3 itself and mec-17.
                                              
Member of lists (Publications lists):
                                              Lund et al 2002  Fig4 Mount 15                                    

F01D5.8 F01D5.8 P W All gene names: F01D5.8; 2O303; CE18565; WBGene00008498; WP:CE18565
                                              
Member of lists (Publications lists):
                                              Reinke et al 2004, list of genes in                               
                                              cluster order, Reinke et al 2004, mixed sperm soma,                                
                                              Reinke et al 2004, GO categories, Reinke et al 2004,                               
                                              list of genes in cluster D, Reinke et al 2004, fem3                                
                                              enriched genes, Zhang et al. 2002, Fig2b overexpressed                             
                                              in mec-3MT                                                                         

F10A3.11 F10A3.11 P W All gene names: F10A3.11; 5Q645; CE15776; WBGene00008636; WP:CE15776
                                              
Member of lists (Publications lists):
                                              ViswanathanM et al 2005  S2 sir-2.1                               
                                              regulated, ViswanathanM et al 2005  S2 daf-16                                      
                                              Resveratrol, ViswanathanM et al 2005 S2 Resveratrol                                
                                              regulate WT, Zhang et al 2002, T1 mec-3 dependent                                  
                                              genes, Zhang et al. 2002, Fig2b overexpressed in                                   
                                              mec-3MT                                                                            

F14D12.4 mec-2 P W All gene names: mec-2; F14D12.4; CE04393; CE30952; CE37633; NM_171691; WBGene00003166; WP:CE04393; WP:CE30952; WP:CE37633; XG209 WormBase description: The mec-2 gene encodes a stomatin homolog required to sense gentle mechanical stimuli (e.g. touch) along the body wall.
                                              
Member of lists (Publications lists):
                                              McCarroll et al 2004  SFig1-4                                     
                                              conserved w/ Drosoph, ViswanathanM et al 2005  S2                                  
                                              sir-2.1 regulated, Wang et al 2003  S4 TransientList,                              
                                              Wang et al 2003  S3  genes pass one-way ANOVA, Wang et                             
                                              al 2003  S4 genes pass two-wayANOVA P0                                             

F16F9.5 mec-10 P W All gene names: deg-2; mec-10; F16F9.5; CE09444; NM_077037; WBGene00003174; WP:CE09444; XJ86 WormBase description: The mec-10 gene encodes an amiloride-sensitive Na+ channel protein (degenerin) required to sense gentle mechanical stimuli (e.g. touch) along the body wall; it is paralogous to mec-4, which has similar function in vivo. WormBase CDS description: degenerin
F37C12.12 mec-14 P W All gene names: mec-14; F37C12.12; 3I280; CE00825; NM_066179; WBGene00003176; WP:CE00825 WormBase description: mec-14 encodes a protein with similarity to the beta-subunits of Shaker-type potassium channels, which are members of the aldo-keto reductase superfamily; MEC-14 is required for response to gentle touch by the six touch receptor neurons, and likely functions to regulate activity of the MEC-4 and MEC-10 degenerin channels; mec-14 expression is detected solely in the touch receptor neurons and is dependent on the MEC-3 LIM domain transcription factor; proper MEC-14 localization in the touch receptor neurons is dependent on MEC-12/alpha-tubulin.
                                              
Member of lists (Publications lists):
                                              McCarroll et al 2004  SFig5 conserved                             
                                              w/ yeast, McCarroll et al 2004  SFig1-4 conserved w/                               
                                              Drosoph                                                                            

F37C12.9 rps-14 P W All gene names: rps-14; F37C12.9; F37C12.9.1; F37C12.9.2; 3I268; CE00821; NM_066171; WBGene00004483; WP:CE00821 WormBase description: rps-14 encodes a small ribosomal subunit S14 protein; by homology, RPS-14 is predicted to function in protein biosynthesis; in C. elegans, RPS-14 activity is required for embryonic and germline development, as well as the overall health of the animal. WormBase CDS description: Ribosomal protein S14
                                              
Member of lists (Publications lists):
                                              McCarroll et al 2004  SFig5 conserved                             
                                              w/ yeast, McCarroll et al 2004  SFig1-4 conserved w/                               
                                              Drosoph, ViswanathanM et al 2005  S2 sir-2.1 regulated                             

F42A9.9 F42A9.9 P W All gene names: F42A9.9; 4J400; CE38603; WBGene00018338; WP:CE38603
                                              
Member of lists (Publications lists):
                                              Zhang et al. 2002, Fig2b overexpressed                            
                                              in mec-3MT                                                                         

F47B10.7 F47B10.7 P W All gene names: acbp-3; F47B10.7; F47B10.7.1; F47B10.7.2; CE32423; NM_077421; WBGene00009818; WP:CE32423; XL523 WormBase description: acyl-CoA-binding protein
                                              
Member of lists (Publications lists):
                                              Reinke et al 2004, list of genes in                               
                                              cluster order, Reinke et al 2004, fem3 enriched genes,                             
                                              Reinke et al 2004, list of genes in cluster C, Reinke                              
                                              et al 2004, mixed sperm soma, Romagnolo et al 2002                                 
                                              Fig3b Metabolism, ViswanathanM et al 2005  S2 sir-2.1                              
                                              regulated, Wang et al 2003  S3  genes pass one-way                                 
                                              ANOVA, Wang et al 2003  S4 genes pass two-wayANOVA P0,                             
                                              Wang et al 2003  S4 LateList, Zhang et al. 2002, Fig2b                             
                                              overexpressed in mec-3MT                                                           

F54E2.2 F54E2.2 P W All gene names: F54E2.2; R05D8.O; 5D275; CE17106; WBGene00018824; WP:CE17106
                                              
Member of lists (Publications lists):
                                              Zhang et al 2002, T1 mec-3 dependent                              
                                              genes, Zhang et al. 2002, Fig2b overexpressed in                                   
                                              mec-3MT                                                                            

F57H12.7 mec-17 P W All gene names: mec-17; F57H12.7; 4I750; CE17128; NM_068936; WBGene00003178; WP:CE17128 WormBase description: mec-17 encodes a protein that has no clearly recognizable motifs yet shares a domain of similarity with an additional C. elegans protein as well as proteins from Drosophila, mouse, and human; MEC-17 activity is required for maintaining the differentiated state of the touch receptors, and hence the animal's touch sensitivity, during later stages of larval development; mec-17 is expressed solely in the touch receptor cells from late embryogenesis through adulthood, and this expression is dependent upon the MEC-3 LIM homeodomain transcription factor; in turn, as MEC-17 is necessary for maintaining differentiated touch receptors, its activity is required for continued expression of MEC-3 and the MEC-7 beta-tubulin.
                                              
Member of lists (Publications lists):
                                              McCarroll et al 2004  SFig1-4                                     
                                              conserved w/ Drosoph, Murphy et al 2003  Fig2 Class1                               
                                              elongate lifespan, Zhang et al 2002, T1 mec-3 dependent                            
                                              genes                                                                              

K03H1.4 K03H1.4 P W All gene names: K03H1.4; 3L17; CE00475; WBGene00010539; WP:CE00475 WormBase description: Transthyretin-like family
                                              
Member of lists (Publications lists):
                                              McElwee et al 2003  T1 targets of                                 
                                              daf-16, Reinke et al 2004, list of genes in cluster A,                             
                                              Reinke et al 2004, list of genes in cluster order,                                 
                                              ViswanathanM et al 2005  S2 sir-2.1 regulated, Wang et                             
                                              al 2003  S3  genes pass one-way ANOVA, Wang et al 2003                             
                                              S4 genes pass two-wayANOVA P0, Wang et al 2003  S4                                 
                                              Dauer Enriched, Zhang et al 2002, T1 mec-3 dependent                               
                                              genes, Zhang et al. 2002, Fig2b overexpressed in                                   
                                              mec-3MT                                                                            

T01C8.7 mec-4 P W All gene names: mec-13; mec-4; T01C8.7; CE39109; NM_078311; WBGene00003168; WP:CE39109; XR418 WormBase description: mec-4 encodes an amiloride-sensitive Na+ channel protein (degenerin) required to sense gentle mechanical stimuli (e.g. touch) along the body wall; MEC-4 is paralogous to, and coexpressed with, MEC-10, in all six touch cell neurons where they form a heteromeric mechanotransduction channel.
                                              
Member of lists (Publications lists):
                                              ViswanathanM et al 2005  S2 daf-16                                
                                              Resveratrol                                                                        

T07D1.3 T07D1.3 P W All gene names: T07D1.3; CE04909; WBGene00020302; WP:CE04909; XD60
                                              
Member of lists (Publications lists):
                                              Shen et al 2005  T1 hif-1 depend                                  
                                              hypoxia, ViswanathanM et al 2005  S2 sir-2.1 regulated,                            
                                              Zhang et al. 2002, Fig2b overexpressed in mec-3MT                                  

T07H8.4 mec-1 P W All gene names: che-4; mec-1; T07H8.4; T07H8.4d.1; T07H8.4d.2; T07H8.4f.1; T07H8.4f.2; 5H445; CE37668; CE37669; CE37670; CE37671; CE37672; CE37673; CE37674; CE37675; NM_171477; NM_171478; WBGene00003165; WP:CE37668; WP:CE37669; WP:CE37670; WP:CE37671; WP:CE37672; WP:CE37673; WP:CE37674; WP:CE37675 WormBase description: mec-1 encodes proteins with multiple disulfide-linked EGF and Kunitz domains; MEC-1 activity is required for normal mechanosensory behavior, and specifically for: 1) localization of the touch receptor degenerin channel complex, 2) accumulation of MEC-5/collagen into the extracellular matrix surrounding touch receptor neurons, and 3) attachment of touch receptor processes to the body wall; mec-1 promoter-GFP fusions indicate that, in addition to the six touch receptors, mec-1 can be expressed in many lateral neurons, the PVT interneuron, and the intestinal muscle; mec-1 expression in the touch receptors is, however, sufficient to rescue touch sensitivity in mec-1 mutant animals; MEC-1 appears to be an extracellular protein that: 1) binds to touch receptor processes uniformly and in a punctate pattern and 2) colocalizes with MEC-5 and degenerin channel puncta on these processes; while localization of MEC-1 into puncta requires the activity of mec-5 and mec-9, uniform MEC-1 localization requires the activity of him-4; in addition, proper organization and distribution of MEC-1, MEC-5, and the degenerin channel complex puncta appears to be regulated by interactions with adjacent epidermal tissue.
W05H9.1 W05H9.1 P W All gene names: W05H9.1; W05H9.1.1; W05H9.1.2; CE05036; WBGene00021048; WP:CE05036; XG891
                                              
Member of lists (Publications lists):
                                              Murphy et al 2003  Fig2 Class1                                    
                                              elongate lifespan, Reinke et al 2004, list of genes in                             
                                              cluster order, Reinke et al 2004, list of genes in                                 
                                              cluster B, ViswanathanM et al 2005  S2 sir-2.1                                     
                                              regulated, Zhang et al 2002, T1 mec-3 dependent genes,                             
                                              Zhang et al. 2002, Fig2b overexpressed in mec-3MT                                  

W08E12.3 W08E12.3 P W All gene names: W08E12.3; W08E12.I; 4E69; CE21278; WBGene00021084; WP:CE21278
                                              
Member of lists (Publications lists):
                                              Reinke et al 2004, list of genes in                               
                                              cluster order, Reinke et al 2004, list of genes in                                 
                                              cluster B, ViswanathanM et al 2005  S2 sir-2.1                                     
                                              regulated, Wang et al 2003  S3  genes pass one-way                                 
                                              ANOVA, Wang et al 2003  S4 genes pass two-wayANOVA P0,                             
                                              Wang et al 2003  S4 LateList, Zhang et al 2002, T1                                 
                                              mec-3 dependent genes, Zhang et al. 2002, Fig2b                                    
                                              overexpressed in mec-3MT                                                           

W08E12.5 W08E12.5 P W All gene names: W08E12.5; 4E65; WBGene00021086
                                              
Member of lists (Publications lists):
                                              Reinke et al 2004, list of genes in                               
                                              cluster order, Reinke et al 2004, list of genes in                                 
                                              cluster B, ViswanathanM et al 2005  S2 sir-2.1                                     
                                              regulated, Zhang et al. 2002, Fig2b overexpressed in                               
                                              mec-3MT                                                                            

Y38F2AR.4 Y38F2AR.4 P W All gene names: Y38F2AR.4; 4D135; WBGene00021422
                                              
Member of lists (Publications lists):
                                              ViswanathanM et al 2005  S2 sir-2.1                               
                                              regulated, Zhang et al. 2002, Fig2b overexpressed in                               
                                              mec-3MT                                                                            

Y54G11A.1 Y54G11A.1 P W All gene names: Y54G11A.1; 2O546; CE22472; WBGene00013212; WP:CE22472
                                              
Member of lists (Publications lists):
                                              Reinke et al 2004, intrinsic, Reinke                              
                                              et al 2004, wt vs glp-4 enriched genes, Reinke et al                               
                                              2004, list of genes in cluster order, Reinke et al                                 
                                              2004, list of genes in cluster E, ViswanathanM et al                               
                                              2005  S2 daf-16 Resveratrol, Zhang et al 2002, T1 mec-3                            
                                              dependent genes, Zhang et al. 2002, Fig2b overexpressed                            
                                              in mec-3MT                                                                         

ZK154.3 mec-7 P W All gene names: mec-7; ZK154.3; CE15257; NM_076912; WBGene00003171; WP:CE15257; XI394 WormBase description: mec-7 encodes a beta-tubulin required for touch sensitivity along the body wall, and for normal levels of locomotor activity; it is strongly expressed in six touch receptor neurons, with weak expression in FLP, PVD, and BDU cells. WormBase CDS description: beta tubulin
                                              
Member of lists (Publications lists):
                                              Roy et al 2002  S3 muscle genes,                                  
                                              ViswanathanM et al 2005  S2 sir-2.1 regulated