Lund et al 2002 Aging time course Fig3A muscle, 44 genes

Gene list file name:Lund2002_Aging_time_course.Fig3A_muscle.txt
Type of gene identifier:Cosmid name
Description:Lund et al 2002 Fig3A muscle  
Organism:Caenorhabditis elegans (nematode)
Gene list type:Experimental

Gene name             Source Gene ID          Annotation                                                  Date       Added by    

B0304.1 hlh-1 P W All gene names: hlh-1; B0304.1; 2E811; CE02423; CE30067; CE31766; MyoD1; WBGene00001948; WP:CE02423; WP:CE30067; WP:CE31766 WormBase description: hlh-1 encodes a basic helix-loop-helix (bHLH) transcription factor that is the sole C. elegans member of the myogenic regulatory factor (MRF) subgroup of bHLH proteins; in C. elegans, HLH-1 activity is required during embryonic development for the proper differentiation and function of body wall muscle cells, indicating that unlike its vertebrate counterparts, hlh-1 is not absolutely required for body wall muscle specification; however, ectopic expression of hlh-1 in the embryo is sufficient to convert nearly all embryonic cell types to a muscle-like fate; in regulating body wall muscle cell development in some cell lineages, hlh-1 likely lies downstream of the PAL-1 homeodomain protein that is required for specification of the C and D founder cell fates; HLH-1 is expressed in nuclei and first appears in body wall muscle precursors beginning at the ~80-cell stage of embryogenesis; expression then continues in these cells and their differentiated descendants throughout embryonic, larval, and adult stages of development. WormBase CDS description: helix-loop-helix transcription factor
                                              
Member of lists (Publications lists):
                                              Baugh et al 2005, validated PAL-1                                 
                                              target genes, Baugh et al 2005, PAL-1 target genes,                                
                                              McCarroll et al 2004  SFig1-4 conserved w/ Drosoph, Roy                            
                                              et al 2002  S2 positivecontrol L1 muscle, ViswanathanM                             
                                              et al 2005  S2 sir-2.1 regulated                                                   

C02B8.4 hlh-8 P W All gene names: hlh-8; C02B8.4; CE24777; NM_076966; WBGene00001953; WP:CE24777; XI737 WormBase description: The hlh-8 gene encodes a helix-loop-helix protein required for normal muscle development, and hence for normal defecation and egg-laying. WormBase CDS description: MYC family of helix-loop-helix transcription factors
                                              
Member of lists (Publications lists):
                                              McCarroll et al 2004  SFig1-4                                     
                                              conserved w/ Drosoph, ViswanathanM et al 2005  S2                                  
                                              sir-2.1 regulated, ViswanathanM et al 2005  S2 daf-16                              
                                              Resveratrol                                                                        

C13C12.1 cal-1 P W All gene names: cal-1; C13C12.1; 5M996; CE08132; NM_073737; WBGene00000285; WP:CE08132 WormBase description: a homolog of calmodulin. WormBase CDS description: calmodulin like protein
C18H9.7 C18H9.7 P W All gene names: rpy-1; C18H9.7; 2G994; CE01807; NM_062964; WBGene00004507; WP:CE01807 WormBase description: rpy-1 is orthologous to the human gene 43KDA ACETYLCHOLINE RECEPTOR-ASSOCIATED PROTEIN (RAPSN; OMIM:601592), which when mutated leads to congenital myasthenic syndrome. WormBase CDS description: postsynaptic protein
                                              
Member of lists (Publications lists):
                                              Jones et al 2001  Dauer specific genes                            
                                              P<0.05, Lund et al 2002  Fig3B neuro-specific genes,                               
                                              Lund et al 2002  Aging time course Fig3A muscle,                                   
                                              McCarroll et al 2004  SFig1-4 conserved w/ Drosoph,                                
                                              Reinke et al 2004, list of genes in cluster A, Reinke                              
                                              et al 2004, list of genes in cluster order,                                        
                                              ViswanathanM et al 2005  S2 sir-2.1 regulated, Wang et                             
                                              al 2003  S3  genes pass one-way ANOVA, Wang et al 2003                             
                                              S8 SAGE genes in the dauer exit, Wang et al 2003  S7                               
                                              SAGE genes in the dataset, Wang et al 2003  S4 Early                               
                                              genes, Wang et al 2003  S4 genes pass two-wayANOVA P0                              

C23F12.2 C23F12.2 P W All gene names: C23F12.2; CE04046; WBGene00016007; WP:CE04046; XK23 WormBase description: actin-binding
                                              
Member of lists (Publications lists):
                                              Jones et al 2001  Non dauer genes                                 
                                              P<0.05, Lund et al 2002  Aging time course Fig3A                                   
                                              muscle, McCarroll et al 2004  SFig1-4 conserved w/                                 
                                              Drosoph                                                                            

C27H5.5 col-36 P W All gene names: col-36; C27H5.5; 2H458; CE06893; NM_063086; WBGene00000613; WP:CE06893 WormBase description: col-36 encodes a collagen protein; expressed during the L1 to L2 and L2 to dauer larval stage molts. WormBase CDS description: cuticular collagen
                                              
Member of lists (Publications lists):
                                              ViswanathanM et al 2005  S2 sir-2.1                               
                                              regulated, ViswanathanM et al 2005  S2 daf-16                                      
                                              Resveratrol                                                                        

C36E6.5 mlc-2 P W All gene names: mlc-2; C36E6.5; C36E6.5.1; C36E6.5.2; C36E6.B; CE20542; NM_078427; WBGene00003370; WP:CE20542; XS70
                                              
Member of lists (Publications lists):
                                              Reinke et al 2004, list of genes in                               
                                              cluster A, Reinke et al 2004, list of genes in cluster                             
                                              order, Roy et al 2002  S2 positivecontrol L1 muscle                                

C44H4.3 sym-1 P W All gene names: sym-1; C44H4.3; CE08724; NM_078025; WBGene00006366; WP:CE08724; XP201 WormBase description: sym-1 encodes a protein containing 15 contiguous leucine-rich repeats (LRRs) that functionally overlaps with sym-5 and interacts with mec-8 with respect to embryonic viability and attachment of body muscle to the extracellular cuticle; expression begins at the time of embryonic elongation and SYM-1 is secreted from the apical hypodermal surface of the embryo WormBase CDS description: Drosophila chaoptin protein like
                                              
Member of lists (Publications lists):
                                              Reinke et al 2004, list of genes in                               
                                              cluster order, Reinke et al 2004, list of genes in                                 
                                              cluster B, ViswanathanM et al 2005  S2 daf-16                                      
                                              Resveratrol, Wang et al 2003  S3  genes pass one-way                               
                                              ANOVA, Wang et al 2003  S4 LateList, Wang et al 2003                               
                                              S4 genes pass two-wayANOVA P0                                                      

C48A7.1 egl-19 P W All gene names: eat-12; egl-19; pat-5; C48A7.1; 4I183; CE28820; CE31165; NM_171379; WBGene00001187; WP:CE28820; WP:CE31165 WormBase description: egl-19 encodes an ortholog of the alpha subunit of mammalian L-type calcium ion channels that affects muscle contraction in late embryonic morphogenesis, movement, egg-laying, mating and feeding; egl-19 is expressed in muscle cells and some neurons.
                                              
Member of lists (Publications lists):
                                              Reinke et al 2004, list of genes in                               
                                              cluster order, Reinke et al 2004, list of genes in                                 
                                              cluster B, ViswanathanM et al 2005  S2 sir-2.1                                     
                                              regulated                                                                          

DY3.7 sup-17 P W All gene names: sup-17; DY3.7; 1J373; CE15751; NM_059976; WBGene00006324; WP:CE15751 WormBase description: sup-17 encodes an ADAM protein, an integral membrane disintegrin and zinc-activated metalloproteinase, orthologous to Drosophila and mouse KUZBANIAN and the vertebrate ADAM10 proteins; SUP-17 is required maternally for embryonic development and plays a role in LIN-12/Notch-mediated cell signaling required for several cell fate decisions during vulval development; SUP-17 is also required for normal body morphology and male tail development; SUP-17 functions cell autonomously to facilitate LIN-12 signaling and requires the LIN-12 extracellular domain to do so. WormBase CDS description: Zinc-binding metalloprotease domain
                                              
Member of lists (Publications lists):
                                              McCarroll et al 2004  SFig1-4                                     
                                              conserved w/ Drosoph, Reinke et al 2004, list of genes                             
                                              in cluster order, Reinke et al 2004, list of genes in                              
                                              cluster E                                                                          

F07A5.7 unc-15 P W All gene names: unc-15; F07A5.7; F07A5.7.1; F07A5.7.2; F07A5.7.3; F07A5.7.4; 1H954; CE09197; NM_059684; WBGene00006754; WP:CE09197 WormBase description: The unc-15 gene encodes a paramyosin ortholog; UNC-15 protein physically interacts with MHC A, one isoform of myosin heavy chain (MHC) in striated muscle; UNC-15 accumulation is decreased in the absence of UNC-54 (myosin B), implying that degradation of UNC-15 is inhibited by its binding myosin B; conversely, myosin B (but not MYO-3/myosin A) fails to accumulate in unc-15 mutants. WormBase CDS description: paramyosin
                                              
Member of lists (Publications lists):
                                              McCarroll et al 2004  SFig1-4                                     
                                              conserved w/ Drosoph, Reinke et al 2004, list of genes                             
                                              in cluster order, Reinke et al 2004, list of genes in                              
                                              cluster C, Reinke et al 2004, IVb male soma enriched                               
                                              genes, Roy et al 2002  S2 positivecontrol L1 muscle,                               
                                              ViswanathanM et al 2005  S2 sir-2.1 regulated                                      

F08B6.4 F08B6.4 P W All gene names: unc-87; F08B6.4; F08B6.4c.1; F08B6.4c.2; F08B6.4c.3; 1H338; CE20658; CE27922; CE36924; WBGene00006819; WP:CE20658; WP:CE27922; WP:CE36924 WormBase description: unc-87 encodes, through alternative splicing, two proteins that are required to maintain the structure of myofilaments in body wall muscle cells; UNC-87 proteins resemble the C-terminal repeat region of calponin but have no obvious orthologs outside of nematodes; in vitro, UNC-87 proteins exist as monomers in solution, associate with thin (F-actin) filaments but not with monomeric G-actin, and bundle F-actin filaments; in vivo, UNC-87 proteins reside in the I-band of bodywall muscle, and GFP-tagged UNC-87 associates with actin stress fibers; unc-87 mutants show degeneration of myofilaments, are profoundly immobile, and have noticeable defects in egg-laying; the unc-87 mutant phenotype is partially suppressed by the unc-54(s95) mutation, which lowers myosin activity but leaves myofilaments intact, indicating that UNC-87 prevents damage by mechanical stress on myofilaments.
                                              
Member of lists (Publications lists):
                                              Lund et al 2002  Aging time course                                
                                              Fig3A muscle, Roy et al 2002  S2 positivecontrol L1                                
                                              muscle, ViswanathanM et al 2005  S2 sir-2.1 regulated,                             
                                              ViswanathanM et al 2005  S2 daf-16 Resveratrol                                     

F09E8.7 lev-1 P W All gene names: acr-1; lev-1; tmr-1; F09E8.7; 4N940; CE24888; NM_070133; WBGene00002974; WP:CE24888 WormBase description: lev-1 encodes an alpha subunit of nicotinic acetylcholine receptor (nAChR) which, when mutated, confers resistance to levamisole; LEV-1 is required for completely normal locomotion, and forms a cation channel when coexpressed with UNC-38 or UNC-63 and UNC-29; LEV-1 falls into the 'UNC-29' class of nAChR subunits, which includes UNC-29, ACR-2, and ACR-3. WormBase CDS description: acetylcholine receptor
                                              
Member of lists (Publications lists):
                                              Reinke et al 2004, list of genes in                               
                                              cluster A, Reinke et al 2004, list of genes in cluster                             
                                              order                                                                              

F11C3.3 unc-54 P W All gene names: myo-4; unc-54; F11C3.3; F11C3.3.1; F11C3.3.2; F11C3.3.3; F11C3.3.4; F11C3.3.5; 1P454; CE09349; NM_061195; WBGene00006789; WP:CE09349 WormBase description: unc-54 encodes a muscle myosin class II heavy chain (MHC B); UNC-54 is the major myosin heavy chain expressed in C. elegans and is required for locomotion and egg-laying; in vivo and in vitro, UNC-54 interacts with ITR-1, an IP3 receptor, and this interaction may provide a link between calcium signaling and the muscle cytoskeleton; UNC-54 is a thick filament component that is expressed in multiple muscle cell classes including body wall, intestinal, anal depressor, and sphincter muscles as well as sex-specific muscles that develop postembryonically. WormBase CDS description: myosin heavy chain
                                              
Member of lists (Publications lists):
                                              McCarroll et al 2004  SFig1-4                                     
                                              conserved w/ Drosoph, Roy et al 2002  S2                                           
                                              positivecontrol L1 muscle, ViswanathanM et al 2005  S2                             
                                              sir-2.1 regulated                                                                  

F12F3.1 exp-2 P W All gene names: exp-2; F12F3.1; F12F3.1a.1; F12F3.1a.2; 5G623; CE09359; CE37629; CE37630; CE37631; WBGene00001374; WP:CE09359; WP:CE37629; WP:CE37630; WP:CE37631 WormBase description: exp-2 encodes a member of the six-transmembrane voltage-activated (Kv-type) family of potassium channels; exp-2 is required for normal pharyngeal muscle action potentials and hence, for normal feeding behavior; in addition, exp-2 is required for chemotaxis; when expressed in Xenopus oocytes, EXP-2 displays inward rectifying currents, however when assessed in endogenous pharyngeal tissue, EXP-2 displays hyperpolarization-activated outward currents; an EXP-2 translational reporter fusion is expressed strongly in pharyngeal muscles, amphid, phasmid, and head neurons, posterior enteric muscles, and occasionally faintly in the egg-laying muscles.
                                              
Member of lists (Publications lists):
                                              Reinke et al 2004, list of genes in                               
                                              cluster A, Reinke et al 2004, list of genes in cluster                             
                                              order, ViswanathanM et al 2005  S2 sir-2.1 regulated,                              
                                              Wang et al 2003  S6 removed genes of contamination                                 

F13G3.8 eat-5 P W All gene names: eat-5; F13G3.8; 1H886; CE05620; NM_059667; WBGene00001136; WP:CE05620 WormBase description: eat-5 encodes an innexin, expressed in pharyngeal muscle cell groups pm4 and pm5, that is required for synchronized pharyngeal muscle contractions, and for normal electrical connections between pharyngeal muscle cells; EAT-5 forms electrically permeable intercellular channels (gap junctions), with a predicted membrane topology analogous to that of connexins, which affects electrical coupling between different parts of the pharynx and thus affects feeding. WormBase CDS description: UNC-7 protein like
                                              
Member of lists (Publications lists):
                                              ViswanathanM et al 2005  S2 sir-2.1                               
                                              regulated                                                                          

F14D12.2 unc-97 P W All gene names: unc-97; F14D12.2; CE04392; NM_076542; WBGene00006826; WP:CE04392; XG213 WormBase description: The unc-97 gene encodes a LIM domain-containing protein of the PINCH family that is highly similar to human LIMS1 (OMIM:602567) and LIMS2; UNC-97 functions as an adaptor protein important for assembly of muscle adherens junctions and the mechanosensory functions of the touch neurons; UNC-97 interacts with PAT-4/integrin-linked kinase and with UNC-98; UNC-97 colocalizes with PAT-3/beta integrin at dense bodies, focal adhesion-like muscle attachment structures. WormBase CDS description: LIM domain containing protein
                                              
Member of lists (Publications lists):
                                              McCarroll et al 2004  SFig1-4                                     
                                              conserved w/ Drosoph, Reinke et al 2004, list of genes                             
                                              in cluster A, Reinke et al 2004, list of genes in                                  
                                              cluster order                                                                      

F14F11.1 nShaw1 P W All gene names: F14F11.1; F14F11.1a.1; F14F11.1a.2; F14F11.1a.3; F14F11.1a.4; 2I598; CE32375; CE32376; CE32377; CE32378; CE32379; CE32380; CE32381; CE35858; NSHAW1; WBGene00008819; WP:CE32375; WP:CE32376; WP:CE32377; WP:CE32378; WP:CE32379; WP:CE32380; WP:CE32381; WP:CE35858 WormBase description: potassium channel
F16B3.1 egl-2 P W All gene names: egl-2; F16B3.1; 5B768; CE24905; NM_071001; WBGene00001171; WP:CE24905 WormBase description: egl-2 encodes a voltage-gated potassium channel that affects egg laying, muscle activation, defecation, mechanosensation, and chemosensation; expressed in the intestinal muscle, AFD, ALN, AQR, ASE, AWC, BAG, IL2, PLN, PQR, and URX neurons as well as a subset of sensory neurons in the male tail. WormBase CDS description: channel protein
                                              
Member of lists (Publications lists):
                                              McCarroll et al 2004  SFig1-4                                     
                                              conserved w/ Drosoph, Portman et al 2004 T1 10                                     
                                              previously-known ray gene                                                          

F22E12.4 egl-9 P W All gene names: egl-9; F22E12.4; F22E12.4a.1; F22E12.4a.2; F22E12.4b.1; F22E12.4b.2; 5K955; CE27755; CE31342; CE38327; CE38328; NM_171533; WBGene00001178; WP:CE27755; WP:CE31342; WP:CE38327; WP:CE38328 WormBase description: egl-9 encodes a dioxygenase that negatively regulates hypoxia inducible factor (hif-1) by hydroxylating prolyl residues in HIF-1.
                                              
Member of lists (Publications lists):
                                              Jones et al 2001  Dauer specific genes                            
                                              P<0.05, McCarroll et al 2004  SFig1-4 conserved w/                                 
                                              Drosoph, Wang et al 2003  S7 SAGE genes in the dataset,                            
                                              Wang et al 2003  S8 SAGE genes in the dauer exit                                   

F36A4.10 col-34 P W All gene names: alpha-collagen; col-34; ram-4; F36A4.10; 4F8; CE07185; NM_068119; WBGene00000611; WP:CE07185 WormBase description: col-34 encodes a cuticle collagen protein and is a critical component of male tail cuticle organization affecting ray morphology. WormBase CDS description: cuticular collagen
                                              
Member of lists (Publications lists):
                                              Reinke et al 2004, list of genes in                               
                                              cluster order, Reinke et al 2004, wt herm vs wt herm                               
                                              enriched gen, Reinke et al 2004, list of genes in                                  
                                              cluster B, ViswanathanM et al 2005  S2 daf-16                                      
                                              Resveratrol, ViswanathanM et al 2005  S2 sir-2.1                                   
                                              regulated, Wang et al 2003  S3  genes pass one-way                                 
                                              ANOVA, Wang et al 2003  S4 genes pass two-wayANOVA P0,                             
                                              Wang et al 2003  S4 LateList                                                       

F40E10.3 csq-1 P W All gene names: csq-1; F40E10.3; F40E10.3.1; F40E10.3.2; CE05839; NM_078037; WBGene00000822; WP:CE05839; XP305 WormBase description: calsequestrin like
                                              
Member of lists (Publications lists):
                                              Reinke et al 2004, list of genes in                               
                                              cluster order, Reinke et al 2004, list of genes in                                 
                                              cluster B, Roy et al 2002  S2 positivecontrol L1                                   
                                              muscle, ViswanathanM et al 2005  S2 sir-2.1 regulated,                             
                                              Wang et al 2003  S3  genes pass one-way ANOVA, Wang et                             
                                              al 2003  S4 Dauer Enriched, Wang et al 2003  S4 genes                              
                                              pass two-wayANOVA P0                                                               

F42E11.4 F42E11.4 P W All gene names: tni-1; F42E11.4; CE03311; NM_077505; WBGene00006584; WP:CE03311; XL994 WormBase description: tni-1 encodes a member of the troponin family that affects body morphology, locomotion, egg laying, and epithelial morphogenesis in a large-scale RNAi analysis. WormBase CDS description: troponin I
                                              
Member of lists (Publications lists):
                                              Lund et al 2002  Aging time course                                
                                              Fig3A muscle, Reinke et al 2004, list of genes in                                  
                                              cluster order, Reinke et al 2004, list of genes in                                 
                                              cluster B, ViswanathanM et al 2005  S2 sir-2.1                                     
                                              regulated                                                                          

F54H5.4 mua-1 P W All gene names: mua-1; F54H5.4; 2G911; CE01967; CE37379; WBGene00003480; WP:CE01967; WP:CE37379 WormBase description: mua-1 encodes predicted transcription factor and xKLF homolog that affects cell matrix attachments that are critical for transmission of muscle contractions to the cuticle and for attachment of the uterus to the body wall, such that mutations result in paralysis of movement and prolapse of the uterus through the vulval opening, and many other secondary defects; its putative activation domain modestly activates transcription in COS cells and mua-1 expression is dynamic during development and includes the hypodermis, anterior pharynx, uv1, uv2, uv3, and utse cells of the uterus, and in the hypodermal nuclei bordering the seam.
                                              
Member of lists (Publications lists):
                                              Wang et al 2003  S4 Early genes, Wang                             
                                              et al 2003  S3  genes pass one-way ANOVA, Wang et al                               
                                              2003  S4 genes pass two-wayANOVA P0                                                

F55B12.1 ceh-24 P W All gene names: ceh-24; F55B12.1; 5O295; CE25006; NM_074018; WBGene00000447; WP:CE25006 WormBase description: ceh-24 is orthologous to the human gene SIMILAR TO THYROID TRANSCRIPTION FACTOR 1 (TITF1; OMIM:600635), which when mutated leads to disease. WormBase CDS description: homeobox protein (NK-2 subfamily)
H14N18.1 unc-23 P W All gene names: unc-23; vab-4; H14N18.1; H14N18.1b.1; H14N18.1b.2; 5J419; CE17973; CE33124; CE37777; NM_072906; NM_182342; WBGene00006760; WP:CE17973; WP:CE33124; WP:CE37777
                                              
Member of lists (Publications lists):
                                              GuhaThakurta et al 2002  T1 upregu on                             
                                              heat stress, McCarroll et al 2004  SFig1-4 conserved w/                            
                                              Drosoph, Murphy et al 2003  Fig2 Class1 elongate                                   
                                              lifespan, Reinke et al 2004, list of genes in cluster                              
                                              order, Reinke et al 2004, list of genes in cluster C,                              
                                              Roy et al 2002  S3 muscle genes, ViswanathanM et al                                
                                              2005  S2 sir-2.1 regulated                                                         

H19M22.1 H19M22.1 P W All gene names: H19M22.1; WBGene00043396
                                              
Member of lists (Publications lists):
                                              Lund et al 2002  Aging time course                                
                                              Fig3A muscle                                                                       

K08B12.5 K08B12.5 P W All gene names: tag-59; K08B12.5; 5G738; CE30818; WBGene00006437; WP:CE30818 WormBase description: tag-59/K08B12.5 encodes a serine/threonine-protein kinase that is homologous to human DMK (OMIM:160900l; mutated in dystrophia myotonica I). WormBase CDS description: serine/threonine-protein kinase
                                              
Member of lists (Publications lists):
                                              Lund et al 2002  Aging time course                                
                                              Fig3A muscle, McCarroll et al 2004  SFig1-4 conserved                              
                                              w/ Drosoph, Reinke et al 2004, list of genes in cluster                            
                                              F, Reinke et al 2004, fem1 enriched genes, Reinke et al                            
                                              2004, list of genes in cluster order, Reinke et al                                 
                                              2004, mixed oogenesis soma, Reinke et al 2004, wt herm                             
                                              vs wt male enriched gen, ViswanathanM et al 2005  S2                               
                                              sir-2.1 regulated                                                                  

K11C4.5 unc-68 P W All gene names: kra-1; ryr-1; unc-68; K11C4.5; 5H382; CE12116; NM_072352; WBGene00006801; WP:CE12116 WormBase description: unc-68 encodes a ryanodine receptor ortholog that is expressed in body-wall muscle cells and is required for normal body tension and locomotion; unc-68 mutants are flaccid, sluggish, and resistant to ryanodine, but have normal muscle ultrastructure; UNC-68 is dispensable for excitation-contraction coupling itself, but may amplify its calcium signals; the unc-68/kra-1(kh30) mutation is an S1444N substitution at a putative protein kinase C phosphorylation site; UNC-68 reduced unc-103(sy557)-induced spicule protraction by one half; unc-68 is orthologous to the human genes RYR1 (OMIM:180901, mutated in malignant hyperthermia and central core disease), RYR2 (OMIM:180902, mutated in stress-induced polymorphic ventricular tachycardia), and RYR3 (OMIM:180903). WormBase CDS description: ryanodine receptor
                                              
Member of lists (Publications lists):
                                              McCarroll et al 2004  SFig1-4                                     
                                              conserved w/ Drosoph, Reinke et al 2004, list of genes                             
                                              in cluster order, Reinke et al 2004, list of genes in                              
                                              cluster C, ViswanathanM et al 2005  S2 sir-2.1                                     
                                              regulated, ViswanathanM et al 2005  S2 daf-16                                      
                                              Resveratrol                                                                        

K11G12.2 acr-2 P W All gene names: acr-2; K11G12.2; CE07380; NM_076727; WBGene00000042; WP:CE07380; XH327 WormBase description: A homolog of a non-alpha type nicotinic acetylcholine receptor subunit that forms a functional channel when co-expressed with the unc-38 alpha subunit. WormBase CDS description: nicotinic acetylcholine receptor subunit
                                              
Member of lists (Publications lists):
                                              ViswanathanM et al 2005  S2 sir-2.1                               
                                              regulated                                                                          

K11G12.7 acr-3 P W All gene names: acr-3; K11G12.7; CE28345; NM_076728; WBGene00000043; WP:CE28345; XH331 WormBase description: acr-3 encodes a non-alpha subunit of the nicotinic acetylcholine receptor (nAChR) superfamily; ACR-3 functions as a ligand-gated ion channel that likely mediates fast actions of acetylcholine at neuromuscular junctions and in the nervous system; when coexpressed with UNC-38, an nAChR alpha subunit, the resulting hetero-oligomer can form levamisole-gated channels; ACR-3 is a member of the UNC-29-like group of nAChR subunits. WormBase CDS description: nicotinic acetylcholine receptor subunit
K12F2.1 myo-3 P W All gene names: myo-3; sup-3; K12F2.1; 5M708; CE34936; NM_073664; WBGene00003515; WP:CE34936 WormBase description: myo-3 encodes MHC A, the minor isoform of MHC (myosin heavy chain) that is essential for thick filament formation, and for viability, movement, and embryonic elongation; expressed in body muscle, the somatic sheath cell covering the hermaphrodite gonad, and also expressed in enteric muscle, vulval muscles of the hermaphrodite and the diagonal muscles of the male tail. WormBase CDS description: myosin heavy chain
                                              
Member of lists (Publications lists):
                                              Reinke et al 2004, list of genes in                               
                                              cluster order, Reinke et al 2004, list of genes in                                 
                                              cluster C, Roy et al 2002  S2 positivecontrol L1                                   
                                              muscle, ViswanathanM et al 2005  S2 sir-2.1 regulated                              

M01D7.7 egl-30 P W All gene names: egl-30; gqa-1; M01D7.7; 1C313; CE12272; CE30556; NM_170806; WBGene00001196; WP:CE12272; WP:CE30556 WormBase description: The egl-30 gene encodes an ortholog of the heterotrimeric G protein alpha subunit Gq (Gq/G11 class) that affects viability, locomotion, egg laying, synaptic transmission, and pharyngeal pumping; it genetically interacts with the goa-1 pathway, and is probably expressed ubiquitously, with highest expression in excitable cells. WormBase CDS description: guanine nucleotide-binding protein
                                              
Member of lists (Publications lists):
                                              McCarroll et al 2004  SFig1-4                                     
                                              conserved w/ Drosoph, ViswanathanM et al 2005  S2                                  
                                              sir-2.1 regulated                                                                  

R06C7.10 myo-1 P W All gene names: let-75; myo-1; R06C7.10; R06C7.10.1; R06C7.10.2; 1H836; CE06253; NM_059652; WBGene00002348; WP:CE06253; myosin I WormBase description: let-75 encodes a pharynx-specific type II myosin heavy chain (MHC D); LET-75 is required for pharyngeal muscle contraction and thus for normal feeding behavior and post-embryonic development; in vitro, the LET-75 tail domain interacts with ITR-1, an IP3 receptor, and this interaction has been proposed to mediate, in vivo, increased pharnygeal pumping in response to food; LET-75 is expressed exclusively in pharyngeal muscle. WormBase CDS description: myosin heavy chain
                                              
Member of lists (Publications lists):
                                              Reinke et al 2004, list of genes in                               
                                              cluster order, Reinke et al 2004, list of genes in                                 
                                              cluster C, ViswanathanM et al 2005  S2 sir-2.1                                     
                                              regulated                                                                          

R07A4.1 egl-36 P W All gene names: egl-36; shw-2; R07A4.1; CE18123; NM_077394; WBGene00001202; WP:CE18123; XL361 WormBase description: egl-36 encodes a shaw voltage-gated potassium channel that affects egg laying and defecation; expressed in the uterine, vulval, anal depressor, sphincter, and four anterior head muscles muscles, and in the AVL and DVB neurons. WormBase CDS description: potassium channel protein
                                              
Member of lists (Publications lists):
                                              Wang et al 2003  S4 TransientList,                                
                                              Wang et al 2003  S3  genes pass one-way ANOVA, Wang et                             
                                              al 2003  S4 genes pass two-wayANOVA P0                                             

T01D1.2 etr-1 P W All gene names: etr-1; T01D1.2; T01D1.2a.1; T01D1.2a.2; T01D1.2a.3; 2A459; CE12942; CE28070; CE33441; NM_061272; WBGene00001340; WP:CE12942; WP:CE28070; WP:CE33441 WormBase description: etr-1 encodes a muscle-specific ELAV-type RNA-binding protein, whose homologs include Drosophila ELAV and human CUG-BINDING PROTEIN (CUGBP1; OMIM:601074); etr-1 function is required for embryonic muscle development, which suggests that ETR-1's homology to CUG-BP (implicated in myotonic dystrophy) might reflect conserved roles in development.
                                              
Member of lists (Publications lists):
                                              Roy et al 2002  S2 positivecontrol L1                             
                                              muscle, ViswanathanM et al 2005  S2 sir-2.1 regulated                              

T04C12.6 act-1 P W All gene names: act-1; T04C12.6; T04C12.6.1; T04C12.6.2; T04C12.6.3; 5L561; CE13148; NM_073418; WBGene00000063; WP:CE13148 WormBase description: An actin that affects body wall and pharyngeal muscle structure and function and motility of animals. WormBase CDS description: actin
                                              
Member of lists (Publications lists):
                                              Golden et al 2004, daf-2                                          
                                              differentially expressed , Golden et al 2004, N2 vs                                
                                              daf-2 age different gene, Reinke et al 2004, list of                               
                                              genes in cluster order, Reinke et al 2004, list of                                 
                                              genes in cluster C                                                                 

T08B1.2 T08B1.2 P W All gene names: tnt-4; T08B1.2; 5C468; CE30830; CE33309; NM_071143; NM_182357; WBGene00006589; WP:CE30830; WP:CE33309
                                              
Member of lists (Publications lists):
                                              Lund et al 2002  Aging time course                                
                                              Fig3A muscle, Reinke et al 2004, list of genes in                                  
                                              cluster order, Reinke et al 2004, list of genes in                                 
                                              cluster C, ViswanathanM et al 2005  S2 sir-2.1                                     
                                              regulated, ViswanathanM et al 2005  S2 daf-16                                      
                                              Resveratrol                                                                        

T18D3.4 myo-2 P W All gene names: myo-2; T18D3.4; CE31619; NM_077691; WBGene00003514; WP:CE31619; XN91 WormBase description: myo-2 encodes a muscle-type specific myosin heavy chain isoform; myo-2 is expressed in pharyngeal muscle. WormBase CDS description: myosin heavy chain C
                                              
Member of lists (Publications lists):
                                              Murphy et al 2003  Fig2 Class2 shorten                            
                                              lifespan, ViswanathanM et al 2005  S2 sir-2.1 regulated                            

T21C12.1 unc-49 P W All gene names: unc-49; unc-49A; unc-49B; unc-49C; T21C12.1; T21C12.1c.1; T21C12.1c.2; 3L621; CE02346; CE28082; CE28083; CE28084; CE28085; CE28086; CE35949; WBGene00006784; WP:CE02346; WP:CE28082; WP:CE28083; WP:CE28084; WP:CE28085; WP:CE28086; WP:CE35949 WormBase description: gamma-aminobutyric-acid receptor
                                              
Member of lists (Publications lists):
                                              McCarroll et al 2004  SFig1-4                                     
                                              conserved w/ Drosoph, Roy et al 2002  S2                                           
                                              positivecontrol L1 muscle, ViswanathanM et al 2005  S2                             
                                              sir-2.1 regulated                                                                  

W09B12.1 ace-1 P W All gene names: ace-1; W09B12.1; W09B12.1.1; W09B12.1.2; ACE1; CE07569; NM_078259; WBGene00000035; WP:CE07569; XQ987 WormBase description: ace-1 encodes a class A acetylcholinesterase that functions redundantly with ACE-2 with respect to total class A acetylcholinesterase activity, and that genetically interacts with ace-2 and ace-3; ace-1 is expressed in the body wall muscle, sphincter muscle, head neurons, a few pharyngeal muscle cells, and the diagonal and spicule muscles of the male.
                                              
Member of lists (Publications lists):
                                              McCarroll et al 2004  SFig1-4                                     
                                              conserved w/ Drosoph                                                               

Y48B6A.8 ace-3 P W All gene names: ace-3; Y48B6A.8; 2O499; CE28131; NM_064562; WBGene00000037; WP:CE28131 WormBase description: ace-3 encodes one of four C. elegans acetylcholinesterases (AChE); ACE-3 represents ~5% of the total AChE activity in C. elegans and in vitro, hydrolyzes acetylthio-, butyrylthio-, and propionylthiocholine substrates with equal efficiency; although loss-of-function mutations in ace-3 result in no obvious defects, animals doubly mutant with ace-1 or ace-2 have slight defects in backward locomotion and animals triply mutant for ace-1, -2, and -3 arrest as unhatched, yet fully developed, embryos; ace-3 is the downstream gene in an operon with a fourth AChE-encoding gene, ace-4, and transcriptional reporter fusions with ace-4 upstream sequences direct expression in pharyngeal muscles pm3, 4, 5, and 7, the two CAN (canal associated neuron) cells, midbody dorsal body wall muscles in larvae, and several neurons in the head and anal ganglion
                                              
Member of lists (Publications lists):
                                              ViswanathanM et al 2005  S2 sir-2.1                               
                                              regulated, ViswanathanM et al 2005  S2 daf-16                                      
                                              Resveratrol                                                                        

ZC101.2 unc-52 P W All gene names: unc-52; ZC101.2; 2O938; CE15028; CE15030; CE15034; CE18424; CE37074; NM_064643; NM_064644; NM_064645; NM_064646; WBGene00006787; WP:CE15028; WP:CE15030; WP:CE15034; WP:CE18424; WP:CE37074 WormBase description: The unc-52 gene encodes perlecan, a protein orthologous to human basement membrane-specific heparan sulfate proteoglycan core protein (HSPG2; OMIM:142461, which when mutated leads to Schwartz-Jampel syndrome or dyssegmental dysplasia); UNC-52 plays essential roles in muscle structure development and regulation of growth factor-like signaling pathways; UNC-52 is synthesized by the hypodermis and localizes to the extracellular matrix between hypodermis and muscle.
                                              
Member of lists (Publications lists):
                                              Reinke et al 2004, intrinsic, Reinke                              
                                              et al 2004, wt vs glp-4 enriched genes, Roy et al 2002                             
                                              S2 positivecontrol L1 muscle, ViswanathanM et al 2005                              
                                              S2 sir-2.1 regulated, Wang et al 2003  S4 Climbing,                                
                                              Wang et al 2003  S3  genes pass one-way ANOVA, Wang et                             
                                              al 2003  S4 genes pass two-wayANOVA P0                                             

ZK1058.2 pat-3 P W All gene names: epi-2; pat-3; ZK1058.2; ZK1058.2.1; ZK1058.2.2; 3F0; CE01102; INTB/1; NM_065386; WBGene00003930; WP:CE01102 WormBase description: beta integrin
                                              
Member of lists (Publications lists):
                                              McCarroll et al 2004  SFig1-4                                     
                                              conserved w/ Drosoph, Reinke et al 2004, fem1 enriched                             
                                              genes, Reinke et al 2004, mixed oogenesis soma,                                    
                                              ViswanathanM et al 2005  S2 sir-2.1 regulated