Portman et al 2004 T1 10 previously-known ray gene, 8 genes

Gene list file name:Portman2004.T1_10_previously-known_ray-genes.txt
Type of gene identifier:Cosmid name
Description:Portman et al 2004 Table1 10 previously-known ray genes  
Organism:Caenorhabditis elegans (nematode)
Gene list type:Experimental

Gene name             Source Gene ID          Annotation                                                  Date       Added by    

B0432.5 B0432.5 P W All gene names: cat-2; B0432.5; 2A549; CE32103; CE37742; NM_061287; NM_182103; WBGene00000296; WP:CE32103; WP:CE37742 WormBase description: cat-2 encodes a putative tyrosine hydroxylase that affects dopamine levels that in turn affect locomotory slowing in response to food; expressed in dopamanergic as well as other neurons, male spicules, and male ray neurons.
                                              
Member of lists (Publications lists):
                                              McCarroll et al 2004  SFig1-4                                     
                                              conserved w/ Drosoph, Portman et al 2004 T1 10                                     
                                              previously-known ray gene, Romagnolo et al 2002  Fig3b                             
                                              signaling                                                                          

F16B3.1 F16B3.1 P W All gene names: egl-2; F16B3.1; 5B768; CE24905; NM_071001; WBGene00001171; WP:CE24905 WormBase description: egl-2 encodes a voltage-gated potassium channel that affects egg laying, muscle activation, defecation, mechanosensation, and chemosensation; expressed in the intestinal muscle, AFD, ALN, AQR, ASE, AWC, BAG, IL2, PLN, PQR, and URX neurons as well as a subset of sensory neurons in the male tail. WormBase CDS description: channel protein
                                              
Member of lists (Publications lists):
                                              McCarroll et al 2004  SFig1-4                                     
                                              conserved w/ Drosoph, Portman et al 2004 T1 10                                     
                                              previously-known ray gene                                                          

F33H1.5 F33H1.5 P W All gene names: srd-1; F33H1.5; 2K470; CE02207; NM_063794; WBGene00005079; WP:CE02207 WormBase description: srd-1 encodes a seven transmembrane chemosensory receptor; SRD-1 is expressed in the ASI chemosensory neurons; SRD-1 expression in ASI is repressed in the presence of dauer pheromone at concentrations lower than that which induces dauer formation.
                                              
Member of lists (Publications lists):
                                              Portman et al 2004 T1 10                                          
                                              previously-known ray gene, ViswanathanM et al 2005  S2                             
                                              daf-16 Resveratrol                                                                 

T23G5.5 T23G5.5 P W All gene names: dat-1; T23G5.5; 3K335; CE25124; NM_066642; WBGene00000934; WP:CE25124 WormBase description: dat-1 is orthologous to the human gene NOREPINEPHRINE TRANSPORTER (SLC6A2; OMIM:163970), which when mutated leads to disease. WormBase CDS description: sodium:neurotransmitter symporter
                                              
Member of lists (Publications lists):
                                              Link et al 2003  T2 Abeta induced,                                
                                              McCarroll et al 2004  SFig1-4 conserved w/ Drosoph,                                
                                              Portman et al 2004 T1 10 previously-known ray gene,                                
                                              ViswanathanM et al 2005  S2 sir-2.1 regulated,                                     
                                              ViswanathanM et al 2005  S2 daf-16 Resveratrol                                     

T24C2.1 T24C2.1 P W All gene names: ram-5; T24C2.1; CE31070; NM_078021; WBGene00004301; WP:CE31070; XP173 WormBase description: cuticlin like
                                              
Member of lists (Publications lists):
                                              Portman et al 2004 T1 10                                          
                                              previously-known ray gene, ViswanathanM et al 2005  S2                             
                                              daf-16 Resveratrol                                                                 

Y73F8A.1 Y73F8A.1 P W All gene names: pdk-2; pkd-2; Y73F8A.1; Y73F8A.A; 4P994; CE38663; NM_070437; WBGene00004035; WP:CE38663 WormBase description: pkd-2 encodes an ortholog of human PKD2 (OMIM:173910; mutated in autosomal dominant polycystic kidney disease) that is expressed in the cilia of three types of male-specific sensory neurons and that is required for two aspects of male mating behavior; PKD-2 acts with LOV-1; EGL-44 and EGL-46 regulate cell-specific expression of lov-1 and pkd-2 to specify the behavioral function of the HOB neuron
                                              
Member of lists (Publications lists):
                                              Jiang et al 2001  Fig1 male-enriched                              
                                              neuronal, McCarroll et al 2004  SFig1-4 conserved w/                               
                                              Drosoph, Portman et al 2004 T1 10 previously-known ray                             
                                              gene, Reinke et al 2004, wt herm vs wt herm enriched                               
                                              gen, Reinke et al 2004, IVb male soma enriched genes                               

ZK1290.2 ZK1290.2 P W All gene names: tph-1; ZK1290.2; ZK1290.2b.1; ZK1290.2b.2; 2H841; CE39457; CE39458; NM_063183; WBGene00006600; WP:CE39457; WP:CE39458 WormBase description: tph-1 encodes tryptophan hydroxylase, the enzyme that catalyzes the rate-limiting first step in serotonin biosynthesis; in vivo, tph-1 activity is required for serotonin biosynthesis, and well-fed animals mutant for tph-1 exhibit changes in behavioral and metabolic processes similar to those caused by starvation: slower rates of egg laying and pharyngeal pumping, dauer larval arrest, increased fat storage, and an extended reproductive lifespan; genetic studies indicate that, in regulating feeding and metabolism, tph-1 interacts with the daf-7/TGF-beta and daf-2/insulin-like signaling pathways; a TPH-1::GFP reporter is expressed in the serotonergic neurons: NSM, ADF, HSN (hermaphrodite-specific), CP (male-specific), and also rarely in the AIM and RIH neurons.
                                              
Member of lists (Publications lists):
                                              McCarroll et al 2004  SFig1-4                                     
                                              conserved w/ Drosoph, Portman et al 2004 T1 10                                     
                                              previously-known ray gene                                                          

ZK945.9 ZK945.9 P W All gene names: lov-1; pkd-1; ZK945.10; ZK945.9; 2K400; CE25697; NM_063783; WBGene00003058; WP:CE25697 WormBase description: lov-1 encodes an ortholog of human PKD1 (OMIM:601313; mutated in autosomal dominant polycystic kidney disease) that is expressed in the cilia of three types of male-specific sensory neurons and that is required for two aspects of male mating behavior; LOV-1 acts with PKD-2; EGL-44 and EGL-46 regulate cell-specific expression of lov-1 and pkd-2 to specify the behavioral function of the HOB neuron WormBase CDS description: polycistic kidney disease protein 1 like with repeated domains at the N-terminus
                                              
Member of lists (Publications lists):
                                              Portman et al 2004 T1 10                                          
                                              previously-known ray gene, ViswanathanM et al 2005  S2                             
                                              daf-16 Resveratrol