Lund et al 2002 Aging time course Fig2C heatshock, 25 genes Gene list file name: Lund2002_Aging_time_course.Fig2C_heatshock.txt Type of gene identifier: Cosmid name Description: Lund et al 2002 Aging time course Fig2C heatshock Organism: Caenorhabditis elegans (nematode) Gene list type: Experimental Gene name Source Gene ID All gene names WormBase description WormBase CDS description Proteome description Member of lists (Publications) Other annotations C12C8.1 C12C8.1 hsp-70; C12C8.1; 1J898; CE08110; NM_060084; WBGene00002026; WP:CE08110 hsp-70 encodes a member of the hsp70 family. heat shock protein 70 Custodia et al 2001 T2 heat shock, GuhaThakurta et al 2002 T1 upregu on heat stress, Jones et al 2001 Dauer specific genes P<0.05, Kwon et al 2004 T1 Class1 rapid-induction Ethanol, Lund et al 2002 Aging time course Fig2C heatshock, Lund et al 2002 Fig1 aging-regulated genes, Romagnolo et al 2002 Fig2a heat shock, Shen et al 2005 T1 hif-1indepen hypoxia, ViswanathanM et al 2005 S2 UPR genes, ViswanathanM et al 2005 S2 sir-2.1 regulated, ViswanathanM et al 2005 Fig6A Ethanol HS, Wang et al 2003 S8 SAGE genes in the dauer exit, Wang et al 2003 S7 SAGE genes in the dataset C15H9.6 hsp-3 hsp-3; C15H9.6; C15H9.6.1; C15H9.6.2; C15H9.6.3; CE08177; NM_076618; WBGene00002007; WP:CE08177; XG708 hsp-3 encodes a heat shock response 70 (hsp70) protein orthologous to human glucose regulated protein 78 (grp78/BiP, OMIM:138120); HSP-3 likely functions as a molecular chaperone, and is expressed constitutively (expression is not heat inducible) throughout development with greatest abundance during the L1 larval stage; HSP-3 contains a long hydrophobic amino terminus and a carboxyl terminal KDEL sequence suggesting that it may be retained in the endoplasmic reticulum. heat shock protein McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, list of genes in cluster C, Romagnolo et al 2002 Fig2a heat shock C24G6.5 C24G6.5 dnj-6; C24G6.5; 5F982; NM_072053; WBGene00001024 Lund et al 2002 Aging time course Fig2C heatshock, ViswanathanM et al 2005 S2 sir-2.1 regulated C30C11.4 C30C11.4 C30C11.4; C30C11.4.1; C30C11.4.2; 3J534; CE00103; WBGene00016250; WP:CE00103 Msi3p GuhaThakurta et al 2002 T1 upregu on heat stress, Kwon et al 2004 T1 late-induction Ethanol-response, Lund et al 2002 Aging time course Fig2C heatshock, McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, intrinsic, Reinke et al 2004, wt vs glp-4 enriched genes, Romagnolo et al 2002 Fig2a heat shock, ViswanathanM et al 2005 S2 sir-2.1 regulated, ViswanathanM et al 2005 Fig6A Ethanol HS C37H5.8 C37H5.8 hsp-6; mot-2; C37H5.8; 5F304; CE08631; NM_071890; WBGene00002010; WP:CE08631 hsp-6 encodes a mitochondrial-specific chaperone that is a member of the DnaK/Hsp70 superfamily of molecular chaperones; hsp-6 is believed to be involved in the mitochondrial unfolded protein response, as hsp-6 expression, normally broadly detected from the L1 larval through adult stages of development, is greatly increased in response to treatments that disrupt mitochondrial protein handling; loss of hsp-6 activity via RNAi results in severe growth defects with arrest at embryonic and early larval stages of development. heat shock 70 protein Lund et al 2002 Aging time course Fig2C heatshock, McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Romagnolo et al 2002 Fig2a heat shock, ViswanathanM et al 2005 S2 sir-2.1 regulated C47E8.5 C47E8.5 daf-21; tax-3; C47E8.5; C47E8.5.1; C47E8.5.2; C47E8.5.3; 5P167; CE05441; NM_074225; WBGene00000915; WP:CE05441 daf-21 encodes a member of the Hsp90 family of molecular chaperones; DAF-21 activity is required for larval development, negative regulation of dauer larva formation, and a number of specific chemosensory behaviors, such as the response to chemicals and odorants detected by the ASE and AWC sensory neurons; a daf-21 sensory defect can be rescued by a cyclic GMP analogue, suggesting that, in regulating chemosensory behaviors, DAF-21 acts at a similar point as the DAF-11 guanylyl cyclase; down-regulation of daf-21 via RNAi results in a small but reproducible reduction in age-1 life span, suggesting that daf-21 is part of a chaperone network required for the extended life span seen in age-1 mutant animals. heat shock protein (HSP90) Lund et al 2002 Aging time course Fig2C heatshock, McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, intrinsic, Reinke et al 2004, wt vs glp-4 enriched genes, Romagnolo et al 2002 Fig2a heat shock, ViswanathanM et al 2005 S2 sir-2.1 regulated F08H9.3 F08H9.3 F08H9.3; 5O942; CE09267; WBGene00008591; WP:CE09267 F08H9.3 encodes a heat shock protein (HSP) of the HSP16 class; unlike most HSP16s in C. elegans, it is specifically expressed in a particular tissue (the larval pharynx and the anterior adult pharynx), and its expression is not strongly induced by heat shock; however, F08H9.3 expression is increased by heat shock (with adult expression in the full pharynx) and probably aids heat shock resistance, since F08H9.3(RNAi) animals have sensitivity to heat shock that is sporadically higher than normal; in general, HSP16 proteins are thought to act as passive ligands for unfolded proteins that keep them safe from aggregation until the proteins can be refolded by a large (ATP-consuming) HSP. heat shock protein Kwon et al 2004 T1 Class1 rapid-induction Ethanol, Lund et al 2002 Aging time course Fig2C heatshock, Lund et al 2002 Fig4 Mount 15, Romagnolo et al 2002 Fig2a heat shock F08H9.4 F08H9.4 F08H9.4; 5O946; CE09268; WBGene00008592; WP:CE09268 F08H9.4 encodes a heat shock protein (HSP) of the HSP16 class; unlike most HSP16s in C. elegans, it is specifically expressed in a particular tissue (the excretory canal and ventral nerve-cord neurons), and its expression is only mildly induced by heat shock; however, F08H9.4 expression is increased by heat shock, is induced in a new tissue type (intestine) by heat shock, and probably aids heat shock resistance, since F08H9.4(RNAi) animals die as embryos in heat shock at a higher rate than normal; in general, HSP16 proteins are thought to act as passive ligands for unfolded proteins that keep them safe from aggregation until the proteins can be refolded by a large (ATP-consuming) HSP. heat shock protein Jones et al 2001 Dauer specific genes P<0.05, Kwon et al 2004 T1 Class1 rapid-induction Ethanol, Lund et al 2002 Aging time course Fig2C heatshock, Romagnolo et al 2002 Fig2a heat shock, Shen et al 2005 T1 hif-1indepen hypoxia, Wang et al 2003 S8 SAGE genes in the dauer exit, Wang et al 2003 S6 removed genes of contamination, Wang et al 2003 S7 SAGE genes in the dataset F26D10.3 T28F3.2, hsp-1 hsp-1; F26D10.3; F26D10.3.1; F26D10.3.2; F26D10.3.3; T28F3.2; 4S223; CE09682; NM_070667; WBGene00002005; WP:CE09682 hsp-1 encodes hsp70A, a member of the heat shock family of proteins; hsp70A is closely related to the Drosophila heat inducible hsp70s and the S. cerevisiae SSA hsp70 subfamily; the hsp-1 gene is normally expressed throughout development and upon heat-shock the hsp-1 mRNA is enhanced 2-6 fold; down-regulation of hsp-1 via RNA interference results in a small reduction in the life-span of an age-1 mutant indicating that hsp-1 may play some role in regulating longevity. HSP-1 heat shock 70kd protein A Custodia et al 2001 T2 heat shock, Lund et al 2002 Aging time course Fig2C heatshock, McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, intrinsic, Reinke et al 2004, wt vs glp-4 enriched genes, Romagnolo et al 2002 Fig2a heat shock, ViswanathanM et al 2005 S2 sir-2.1 regulated F39B2.10 F39B2.10 dnj-12; F39B2.10; F39B2.10.1; F39B2.10.2; F39B2.10.3; F39B2.10.4; 1P351; CE16015; NM_061169; WBGene00001030; WP:CE16015 This gene encodes a protein containing a DnaJ ('J') domain. DnaJ, prokaryotic heat shock protein Lund et al 2002 Aging time course Fig2C heatshock, McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Romagnolo et al 2002 Fig2a heat shock, ViswanathanM et al 2005 S2 sir-2.1 regulated F43D9.4 sip-1 sec-1; sip-1; F43D9.4; F43D9.4.1; F43D9.4.2; 3L596; CE00994; NM_066915; SIP/1; WBGene00004798; WP:CE00994 Heat shock hsp20 proteins ReichertK et al 2005 T3 xenobiotic downregulated, Reinke et al 2004, Fig2b shared gemlines, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, intrinsic, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, wt males vs glp4 male enriched , Reinke et al 2004, list of genes in cluster E, Romagnolo et al 2002 Fig2a heat shock, ViswanathanM et al 2005 S2 sir-2.1 regulated F43E2.8 hsp-4 hsp-4; F43E2.8; F43E2.8.1; F43E2.8.2; 2H640; CE07244; NM_063135; WBGene00002008; WP:CE07244 hsp-4 encodes a predicted homolog of the mammalian ER chaperone BiP that affects embryonic and larval viability; expression is most prominent in the spermatheca and transcription of hsp-4 is induced in the gut and in the hypodermis upon ER stress. heat shock protein Kwon et al 2004 T1 late-induction Ethanol-response, Romagnolo et al 2002 Fig2a heat shock, ViswanathanM et al 2005 S2 sir-2.1 regulated, ViswanathanM et al 2005 S2 UPR genes F44E5.4 F44E5.4 F44E5.4; F44E5.4.1; F44E5.4.2; 2M48; CE18679; WBGene00009691; WP:CE18679 Heat shock hsp70 proteins Custodia et al 2001 T2 heat shock, GuhaThakurta et al 2002 T1 upregu on heat stress, Lund et al 2002 Aging time course Fig2C heatshock, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, list of genes in cluster B, Romagnolo et al 2002 Fig2a heat shock, Shen et al 2005 T1 hif-1indepen hypoxia, ViswanathanM et al 2005 S2 sir-2.1 regulated F44E5.5 F44E5.5 F44E5.5; F44E5.5.1; F44E5.5.2; 2M51; WBGene00009692 Heat shock hsp70 proteins Custodia et al 2001 T2 heat shock, GuhaThakurta et al 2002 T1 upregu on heat stress, Lund et al 2002 Aging time course Fig2C heatshock, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, list of genes in cluster B, Romagnolo et al 2002 Fig2a heat shock, Shen et al 2005 T1 hif-1indepen hypoxia, ViswanathanM et al 2005 S2 sir-2.1 regulated F54C9.2 F54C9.2 stc-1; F54C9.2; 2I854; CE32895; NM_063407; STCH; WBGene00006059; WP:CE32895 Heat shock 70Kd protein (HSP70) Kwon et al 2004 T1 late-induction Ethanol-response, Lund et al 2002 Aging time course Fig2C heatshock, Romagnolo et al 2002 Fig2a heat shock, ViswanathanM et al 2005 S2 sir-2.1 regulated K09C4.3 hsp-2 hsp-2; hsp-2ps; K09C4.3; NM_076166; WBGene00002006; XD911 Custodia et al 2001 T2 heat shock, Romagnolo et al 2002 Fig2a heat shock R09E12.3 R09E12.3 R09E12.3; 5B253; CE12646; WBGene00019983; WP:CE12646 Lund et al 2002 Aging time course Fig2C heatshock, McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, intrinsic, Reinke et al 2004, wt vs glp-4 enriched genes, Romagnolo et al 2002 Fig2a heat shock, ViswanathanM et al 2005 S2 sir-2.1 regulated R151.7 R151.7 R151.7; R151.7a.1; R151.7a.2; 3I314; CE39621; CE39622; WBGene00020110; WP:CE39621; WP:CE39622 HSP C62.5 Lund et al 2002 Aging time course Fig2C heatshock, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, intrinsic, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, Romagnolo et al 2002 Fig2a heat shock, ViswanathanM et al 2005 S2 sir-2.1 regulated T05C3.5 T05C3.5 dnj-19; T05C3.5; T05C3.5.1; T05C3.5.2; CE13229; NM_072051; WBGene00001037; WP:CE13229 This gene encodes a protein containing a DnaJ ('J') domain. DNAJ-like protein Lund et al 2002 Aging time course Fig2C heatshock, Romagnolo et al 2002 Fig2a heat shock, ViswanathanM et al 2005 S2 sir-2.1 regulated T05E11.3 T05E11.3 T05E11.3; T05E11.3.1; T05E11.3.2; 4L887; CE06362; WBGene00011480; WP:CE06362 endoplasmin precursor (GRP94) Lund et al 2002 Aging time course Fig2C heatshock, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, list of genes in cluster C, Romagnolo et al 2002 Fig2a heat shock, ViswanathanM et al 2005 S2 sir-2.1 regulated T14G8.3 T14G8.3 T14G8.3; CE37407; CE37408; WBGene00011771; WP:CE37407; WP:CE37408; XN487 T14G8.3 encodes an ortholog of hypoxia-upregulated vertebrate proteins such as human HYOU1; T14G8.3, its C. elegans paralog T24H7.2, and HYOU1 are ER resident hsp70 family molecular chaperone homologs; the grp (glucose regulated protein) 170 family is a collection of related large hsp70 chaperones confined to the ER; members of this family are present in all eukaryotes, participating in a wide range of cellular functions. heat shock protein Lund et al 2002 Aging time course Fig2C heatshock, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, list of genes in cluster C, Romagnolo et al 2002 Fig2a heat shock, ViswanathanM et al 2005 S2 sir-2.1 regulated T15H9.1 T15H9.1 T15H9.1; T15H9.1.1; T15H9.1.2; CE30689; NM_063671; WBGene00011787; WP:CE30689 Lund et al 2002 Aging time course Fig2C heatshock, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph T24H7.2 T24H7.2 T24H7.2; T24H7.2.1; T24H7.2.2; 2G539; CE02884; WBGene00020781; WP:CE02884 T24H7.2 encodes an ortholog of hypoxia-upregulated vertebrate proteins such as human HYOU1; T24H7.2, its C. elegans paralog T14G8.3, and HYOU1 are ER resident hsp70 family molecular chaperone homologs; the grp (glucose regulated protein) 170 family is a collection of related large hsp70 chaperones confined to the ER; members of this family are present in all eukaryotes, participating in a wide range of cellular functions. Lund et al 2002 Aging time course Fig2C heatshock, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Romagnolo et al 2002 Fig2a heat shock, ViswanathanM et al 2005 S2 sir-2.1 regulated T27E4.8 hsp-16 hsp-16.1; hsp-16; T27E4.8; 5J568; CE14249; NM_072953; WBGene00002015; WP:CE14249 hsp-16.1 encodes a 16-kD heat shock protein (HSP) that is a member of the hsp16/hsp20/alphaB-crystallin (HSP16) family of heat shock proteins, and that is identical to the protein encoded by hsp-16.11; an hsp-16.1 reporter fusion, expressed broadly but most strongly in muscle and hypodermis, is induced solely in response to heat shock or other environmental stresses; expression is detectable in somatic tissues in post-gastrulation embryos, all larval stages, and in adults; HSP-16.1 is likely to function as a passive ligand temporarily preventing unfolded proteins from aggregating. heat shock protein HSP16-1 Murphy et al 2003 Fig2 Class1 elongate lifespan, Romagnolo et al 2002 Fig2a heat shock, ViswanathanM et al 2005 S2 sir-2.1 regulated Y46H3A.3 hsp-16.2 hsp-16.2; Y46H3A.3; Y46H3A.D; 5C282; CE22002; NM_071106; WBGene00002016; WP:CE22002 hsp-16.2 encodes a 16-kD heat shock protein (HSP) that is a member of the hsp16/hsp20/alphaB-crystallin (HSP16) family of heat shock proteins; hsp-16.2 expression, strongest in intestine and pharynx, is induced in response to heat shock or other environmental stresses; HSP-16.2 has been shown to interact with intracellular human beta amyloid peptide, a primary component of the extracellular plaques found in Alzheimer's disease; HSP-16.2 is likely to function as a passive ligand temporarily preventing unfolded proteins from aggregating. heat shock protein Golden et al 2004, N2 differentially expressed gen, Golden et al 2004, daf-2 differentially expressed , Link et al 2003 T3 Abeta highly induced, Link et al 2003 T2 Abeta induced, Murphy et al 2003 Fig2 Class1 elongate lifespan, Romagnolo et al 2002 Fig2a heat shock, ViswanathanM et al 2005 S2 sir-2.1 regulated