Lund et al 2002 Aging time course Fig2C heatshock, 25 genes

Gene list file name:Lund2002_Aging_time_course.Fig2C_heatshock.txt
Type of gene identifier:Cosmid name
Description:Lund et al 2002 Aging time course Fig2C heatshock  
Organism:Caenorhabditis elegans (nematode)
Gene list type:Experimental

Gene name             Source Gene ID          Annotation                                                  Date       Added by    

C12C8.1 C12C8.1 P W All gene names: hsp-70; C12C8.1; 1J898; CE08110; NM_060084; WBGene00002026; WP:CE08110 WormBase description: hsp-70 encodes a member of the hsp70 family. WormBase CDS description: heat shock protein 70
                                              
Member of lists (Publications lists):
                                              Custodia et al 2001  T2 heat shock,                               
                                              GuhaThakurta et al 2002  T1 upregu on heat stress,                                 
                                              Jones et al 2001  Dauer specific genes P<0.05, Kwon et                             
                                              al 2004  T1 Class1 rapid-induction Ethanol, Lund et al                             
                                              2002 Aging time course Fig2C heatshock, Lund et al 2002                            
                                               Fig1 aging-regulated genes, Romagnolo et al 2002                                  
                                              Fig2a heat shock, Shen et al 2005  T1 hif-1indepen                                 
                                              hypoxia, ViswanathanM et al 2005  S2 UPR genes,                                    
                                              ViswanathanM et al 2005  S2 sir-2.1 regulated,                                     
                                              ViswanathanM et al 2005  Fig6A Ethanol HS, Wang et al                              
                                              2003  S8 SAGE genes in the dauer exit, Wang et al 2003                             
                                              S7 SAGE genes in the dataset                                                       

C15H9.6 hsp-3 P W All gene names: hsp-3; C15H9.6; C15H9.6.1; C15H9.6.2; C15H9.6.3; CE08177; NM_076618; WBGene00002007; WP:CE08177; XG708 WormBase description: hsp-3 encodes a heat shock response 70 (hsp70) protein orthologous to human glucose regulated protein 78 (grp78/BiP, OMIM:138120); HSP-3 likely functions as a molecular chaperone, and is expressed constitutively (expression is not heat inducible) throughout development with greatest abundance during the L1 larval stage; HSP-3 contains a long hydrophobic amino terminus and a carboxyl terminal KDEL sequence suggesting that it may be retained in the endoplasmic reticulum. WormBase CDS description: heat shock protein
                                              
Member of lists (Publications lists):
                                              McCarroll et al 2004  SFig5 conserved                             
                                              w/ yeast, McCarroll et al 2004  SFig1-4 conserved w/                               
                                              Drosoph, Reinke et al 2004, list of genes in cluster                               
                                              order, Reinke et al 2004, list of genes in cluster C,                              
                                              Romagnolo et al 2002  Fig2a heat shock                                             

C24G6.5 C24G6.5 P W All gene names: dnj-6; C24G6.5; 5F982; NM_072053; WBGene00001024
                                              
Member of lists (Publications lists):
                                              Lund et al 2002 Aging time course                                 
                                              Fig2C heatshock, ViswanathanM et al 2005  S2 sir-2.1                               
                                              regulated                                                                          

C30C11.4 C30C11.4 P W All gene names: C30C11.4; C30C11.4.1; C30C11.4.2; 3J534; CE00103; WBGene00016250; WP:CE00103 WormBase description: Msi3p
                                              
Member of lists (Publications lists):
                                              GuhaThakurta et al 2002  T1 upregu on                             
                                              heat stress, Kwon et al 2004 T1 late-induction                                     
                                              Ethanol-response, Lund et al 2002 Aging time course                                
                                              Fig2C heatshock, McCarroll et al 2004  SFig5 conserved                             
                                              w/ yeast, McCarroll et al 2004  SFig1-4 conserved w/                               
                                              Drosoph, Reinke et al 2004, intrinsic, Reinke et al                                
                                              2004, wt vs glp-4 enriched genes, Romagnolo et al 2002                             
                                              Fig2a heat shock, ViswanathanM et al 2005  S2 sir-2.1                              
                                              regulated, ViswanathanM et al 2005  Fig6A Ethanol HS                               

C37H5.8 C37H5.8 P W All gene names: hsp-6; mot-2; C37H5.8; 5F304; CE08631; NM_071890; WBGene00002010; WP:CE08631 WormBase description: hsp-6 encodes a mitochondrial-specific chaperone that is a member of the DnaK/Hsp70 superfamily of molecular chaperones; hsp-6 is believed to be involved in the mitochondrial unfolded protein response, as hsp-6 expression, normally broadly detected from the L1 larval through adult stages of development, is greatly increased in response to treatments that disrupt mitochondrial protein handling; loss of hsp-6 activity via RNAi results in severe growth defects with arrest at embryonic and early larval stages of development. WormBase CDS description: heat shock 70 protein
                                              
Member of lists (Publications lists):
                                              Lund et al 2002 Aging time course                                 
                                              Fig2C heatshock, McCarroll et al 2004  SFig5 conserved                             
                                              w/ yeast, McCarroll et al 2004  SFig1-4 conserved w/                               
                                              Drosoph, Romagnolo et al 2002  Fig2a heat shock,                                   
                                              ViswanathanM et al 2005  S2 sir-2.1 regulated                                      

C47E8.5 C47E8.5 P W All gene names: daf-21; tax-3; C47E8.5; C47E8.5.1; C47E8.5.2; C47E8.5.3; 5P167; CE05441; NM_074225; WBGene00000915; WP:CE05441 WormBase description: daf-21 encodes a member of the Hsp90 family of molecular chaperones; DAF-21 activity is required for larval development, negative regulation of dauer larva formation, and a number of specific chemosensory behaviors, such as the response to chemicals and odorants detected by the ASE and AWC sensory neurons; a daf-21 sensory defect can be rescued by a cyclic GMP analogue, suggesting that, in regulating chemosensory behaviors, DAF-21 acts at a similar point as the DAF-11 guanylyl cyclase; down-regulation of daf-21 via RNAi results in a small but reproducible reduction in age-1 life span, suggesting that daf-21 is part of a chaperone network required for the extended life span seen in age-1 mutant animals. WormBase CDS description: heat shock protein (HSP90)
                                              
Member of lists (Publications lists):
                                              Lund et al 2002 Aging time course                                 
                                              Fig2C heatshock, McCarroll et al 2004  SFig5 conserved                             
                                              w/ yeast, McCarroll et al 2004  SFig1-4 conserved w/                               
                                              Drosoph, Reinke et al 2004, intrinsic, Reinke et al                                
                                              2004, wt vs glp-4 enriched genes, Romagnolo et al 2002                             
                                              Fig2a heat shock, ViswanathanM et al 2005  S2 sir-2.1                              
                                              regulated                                                                          

F08H9.3 F08H9.3 P W All gene names: F08H9.3; 5O942; CE09267; WBGene00008591; WP:CE09267 WormBase description: F08H9.3 encodes a heat shock protein (HSP) of the HSP16 class; unlike most HSP16s in C. elegans, it is specifically expressed in a particular tissue (the larval pharynx and the anterior adult pharynx), and its expression is not strongly induced by heat shock; however, F08H9.3 expression is increased by heat shock (with adult expression in the full pharynx) and probably aids heat shock resistance, since F08H9.3(RNAi) animals have sensitivity to heat shock that is sporadically higher than normal; in general, HSP16 proteins are thought to act as passive ligands for unfolded proteins that keep them safe from aggregation until the proteins can be refolded by a large (ATP-consuming) HSP. WormBase CDS description: heat shock protein
                                              
Member of lists (Publications lists):
                                              Kwon et al 2004  T1 Class1                                        
                                              rapid-induction Ethanol, Lund et al 2002 Aging time                                
                                              course Fig2C heatshock, Lund et al 2002  Fig4 Mount 15,                            
                                              Romagnolo et al 2002  Fig2a heat shock                                             

F08H9.4 F08H9.4 P W All gene names: F08H9.4; 5O946; CE09268; WBGene00008592; WP:CE09268 WormBase description: F08H9.4 encodes a heat shock protein (HSP) of the HSP16 class; unlike most HSP16s in C. elegans, it is specifically expressed in a particular tissue (the excretory canal and ventral nerve-cord neurons), and its expression is only mildly induced by heat shock; however, F08H9.4 expression is increased by heat shock, is induced in a new tissue type (intestine) by heat shock, and probably aids heat shock resistance, since F08H9.4(RNAi) animals die as embryos in heat shock at a higher rate than normal; in general, HSP16 proteins are thought to act as passive ligands for unfolded proteins that keep them safe from aggregation until the proteins can be refolded by a large (ATP-consuming) HSP. WormBase CDS description: heat shock protein
                                              
Member of lists (Publications lists):
                                              Jones et al 2001  Dauer specific genes                            
                                              P<0.05, Kwon et al 2004  T1 Class1 rapid-induction                                 
                                              Ethanol, Lund et al 2002 Aging time course Fig2C                                   
                                              heatshock, Romagnolo et al 2002  Fig2a heat shock, Shen                            
                                              et al 2005  T1 hif-1indepen hypoxia, Wang et al 2003                               
                                              S8 SAGE genes in the dauer exit, Wang et al 2003  S6                               
                                              removed genes of contamination, Wang et al 2003  S7                                
                                              SAGE genes in the dataset                                                          

F26D10.3 T28F3.2, hsp-1 P W All gene names: hsp-1; F26D10.3; F26D10.3.1; F26D10.3.2; F26D10.3.3; T28F3.2; 4S223; CE09682; NM_070667; WBGene00002005; WP:CE09682 WormBase description: hsp-1 encodes hsp70A, a member of the heat shock family of proteins; hsp70A is closely related to the Drosophila heat inducible hsp70s and the S. cerevisiae SSA hsp70 subfamily; the hsp-1 gene is normally expressed throughout development and upon heat-shock the hsp-1 mRNA is enhanced 2-6 fold; down-regulation of hsp-1 via RNA interference results in a small reduction in the life-span of an age-1 mutant indicating that hsp-1 may play some role in regulating longevity. WormBase CDS description: HSP-1 heat shock 70kd protein A
                                              
Member of lists (Publications lists):
                                              Custodia et al 2001  T2 heat shock,                               
                                              Lund et al 2002 Aging time course Fig2C heatshock,                                 
                                              McCarroll et al 2004  SFig5 conserved w/ yeast,                                    
                                              McCarroll et al 2004  SFig1-4 conserved w/ Drosoph,                                
                                              Reinke et al 2004, intrinsic, Reinke et al 2004, wt vs                             
                                              glp-4 enriched genes, Romagnolo et al 2002  Fig2a heat                             
                                              shock, ViswanathanM et al 2005  S2 sir-2.1 regulated                               

F39B2.10 F39B2.10 P W All gene names: dnj-12; F39B2.10; F39B2.10.1; F39B2.10.2; F39B2.10.3; F39B2.10.4; 1P351; CE16015; NM_061169; WBGene00001030; WP:CE16015 WormBase description: This gene encodes a protein containing a DnaJ ('J') domain. WormBase CDS description: DnaJ, prokaryotic heat shock protein
                                              
Member of lists (Publications lists):
                                              Lund et al 2002 Aging time course                                 
                                              Fig2C heatshock, McCarroll et al 2004  SFig5 conserved                             
                                              w/ yeast, McCarroll et al 2004  SFig1-4 conserved w/                               
                                              Drosoph, Romagnolo et al 2002  Fig2a heat shock,                                   
                                              ViswanathanM et al 2005  S2 sir-2.1 regulated                                      

F43D9.4 sip-1 P W All gene names: sec-1; sip-1; F43D9.4; F43D9.4.1; F43D9.4.2; 3L596; CE00994; NM_066915; SIP/1; WBGene00004798; WP:CE00994 WormBase description: Heat shock hsp20 proteins
                                              
Member of lists (Publications lists):
                                              ReichertK et al 2005  T3 xenobiotic                               
                                              downregulated, Reinke et al 2004, Fig2b shared                                     
                                              gemlines, Reinke et al 2004, list of genes in cluster                              
                                              order, Reinke et al 2004, intrinsic, Reinke et al 2004,                            
                                              wt vs glp-4 enriched genes, Reinke et al 2004, wt males                            
                                              vs glp4 male enriched , Reinke et al 2004, list of                                 
                                              genes in cluster E, Romagnolo et al 2002  Fig2a heat                               
                                              shock, ViswanathanM et al 2005  S2 sir-2.1 regulated                               

F43E2.8 hsp-4 P W All gene names: hsp-4; F43E2.8; F43E2.8.1; F43E2.8.2; 2H640; CE07244; NM_063135; WBGene00002008; WP:CE07244 WormBase description: hsp-4 encodes a predicted homolog of the mammalian ER chaperone BiP that affects embryonic and larval viability; expression is most prominent in the spermatheca and transcription of hsp-4 is induced in the gut and in the hypodermis upon ER stress. WormBase CDS description: heat shock protein
                                              
Member of lists (Publications lists):
                                              Kwon et al 2004 T1 late-induction                                 
                                              Ethanol-response, Romagnolo et al 2002  Fig2a heat                                 
                                              shock, ViswanathanM et al 2005  S2 sir-2.1 regulated,                              
                                              ViswanathanM et al 2005  S2 UPR genes                                              

F44E5.4 F44E5.4 P W All gene names: F44E5.4; F44E5.4.1; F44E5.4.2; 2M48; CE18679; WBGene00009691; WP:CE18679 WormBase description: Heat shock hsp70 proteins
                                              
Member of lists (Publications lists):
                                              Custodia et al 2001  T2 heat shock,                               
                                              GuhaThakurta et al 2002  T1 upregu on heat stress, Lund                            
                                              et al 2002 Aging time course Fig2C heatshock, Reinke et                            
                                              al 2004, list of genes in cluster order, Reinke et al                              
                                              2004, list of genes in cluster B, Romagnolo et al 2002                             
                                              Fig2a heat shock, Shen et al 2005  T1 hif-1indepen                                 
                                              hypoxia, ViswanathanM et al 2005  S2 sir-2.1 regulated                             

F44E5.5 F44E5.5 P W All gene names: F44E5.5; F44E5.5.1; F44E5.5.2; 2M51; WBGene00009692 WormBase description: Heat shock hsp70 proteins
                                              
Member of lists (Publications lists):
                                              Custodia et al 2001  T2 heat shock,                               
                                              GuhaThakurta et al 2002  T1 upregu on heat stress, Lund                            
                                              et al 2002 Aging time course Fig2C heatshock, Reinke et                            
                                              al 2004, list of genes in cluster order, Reinke et al                              
                                              2004, list of genes in cluster B, Romagnolo et al 2002                             
                                              Fig2a heat shock, Shen et al 2005  T1 hif-1indepen                                 
                                              hypoxia, ViswanathanM et al 2005  S2 sir-2.1 regulated                             

F54C9.2 F54C9.2 P W All gene names: stc-1; F54C9.2; 2I854; CE32895; NM_063407; STCH; WBGene00006059; WP:CE32895 WormBase description: Heat shock 70Kd protein (HSP70)
                                              
Member of lists (Publications lists):
                                              Kwon et al 2004 T1 late-induction                                 
                                              Ethanol-response, Lund et al 2002 Aging time course                                
                                              Fig2C heatshock, Romagnolo et al 2002  Fig2a heat                                  
                                              shock, ViswanathanM et al 2005  S2 sir-2.1 regulated                               

K09C4.3 hsp-2 P W All gene names: hsp-2; hsp-2ps; K09C4.3; NM_076166; WBGene00002006; XD911
                                              
Member of lists (Publications lists):
                                              Custodia et al 2001  T2 heat shock,                               
                                              Romagnolo et al 2002  Fig2a heat shock                                             

R09E12.3 R09E12.3 P W All gene names: R09E12.3; 5B253; CE12646; WBGene00019983; WP:CE12646
                                              
Member of lists (Publications lists):
                                              Lund et al 2002 Aging time course                                 
                                              Fig2C heatshock, McCarroll et al 2004  SFig5 conserved                             
                                              w/ yeast, McCarroll et al 2004  SFig1-4 conserved w/                               
                                              Drosoph, Reinke et al 2004, intrinsic, Reinke et al                                
                                              2004, wt vs glp-4 enriched genes, Romagnolo et al 2002                             
                                              Fig2a heat shock, ViswanathanM et al 2005  S2 sir-2.1                              
                                              regulated                                                                          

R151.7 R151.7 P W All gene names: R151.7; R151.7a.1; R151.7a.2; 3I314; CE39621; CE39622; WBGene00020110; WP:CE39621; WP:CE39622 WormBase description: HSP C62.5
                                              
Member of lists (Publications lists):
                                              Lund et al 2002 Aging time course                                 
                                              Fig2C heatshock, McCarroll et al 2004  SFig1-4                                     
                                              conserved w/ Drosoph, Reinke et al 2004, intrinsic,                                
                                              Reinke et al 2004, wt vs glp-4 enriched genes, Reinke                              
                                              et al 2004, wt herm vs wt male enriched gen, Romagnolo                             
                                              et al 2002  Fig2a heat shock, ViswanathanM et al 2005                              
                                              S2 sir-2.1 regulated                                                               

T05C3.5 T05C3.5 P W All gene names: dnj-19; T05C3.5; T05C3.5.1; T05C3.5.2; CE13229; NM_072051; WBGene00001037; WP:CE13229 WormBase description: This gene encodes a protein containing a DnaJ ('J') domain. WormBase CDS description: DNAJ-like protein
                                              
Member of lists (Publications lists):
                                              Lund et al 2002 Aging time course                                 
                                              Fig2C heatshock, Romagnolo et al 2002  Fig2a heat                                  
                                              shock, ViswanathanM et al 2005  S2 sir-2.1 regulated                               

T05E11.3 T05E11.3 P W All gene names: T05E11.3; T05E11.3.1; T05E11.3.2; 4L887; CE06362; WBGene00011480; WP:CE06362 WormBase description: endoplasmin precursor (GRP94)
                                              
Member of lists (Publications lists):
                                              Lund et al 2002 Aging time course                                 
                                              Fig2C heatshock, McCarroll et al 2004  SFig1-4                                     
                                              conserved w/ Drosoph, Reinke et al 2004, list of genes                             
                                              in cluster order, Reinke et al 2004, list of genes in                              
                                              cluster C, Romagnolo et al 2002  Fig2a heat shock,                                 
                                              ViswanathanM et al 2005  S2 sir-2.1 regulated                                      

T14G8.3 T14G8.3 P W All gene names: T14G8.3; CE37407; CE37408; WBGene00011771; WP:CE37407; WP:CE37408; XN487 WormBase description: T14G8.3 encodes an ortholog of hypoxia-upregulated vertebrate proteins such as human HYOU1; T14G8.3, its C. elegans paralog T24H7.2, and HYOU1 are ER resident hsp70 family molecular chaperone homologs; the grp (glucose regulated protein) 170 family is a collection of related large hsp70 chaperones confined to the ER; members of this family are present in all eukaryotes, participating in a wide range of cellular functions. WormBase CDS description: heat shock protein
                                              
Member of lists (Publications lists):
                                              Lund et al 2002 Aging time course                                 
                                              Fig2C heatshock, Reinke et al 2004, list of genes in                               
                                              cluster order, Reinke et al 2004, list of genes in                                 
                                              cluster C, Romagnolo et al 2002  Fig2a heat shock,                                 
                                              ViswanathanM et al 2005  S2 sir-2.1 regulated                                      

T15H9.1 T15H9.1 P W All gene names: T15H9.1; T15H9.1.1; T15H9.1.2; CE30689; NM_063671; WBGene00011787; WP:CE30689
                                              
Member of lists (Publications lists):
                                              Lund et al 2002 Aging time course                                 
                                              Fig2C heatshock, McCarroll et al 2004  SFig1-4                                     
                                              conserved w/ Drosoph                                                               

T24H7.2 T24H7.2 P W All gene names: T24H7.2; T24H7.2.1; T24H7.2.2; 2G539; CE02884; WBGene00020781; WP:CE02884 WormBase description: T24H7.2 encodes an ortholog of hypoxia-upregulated vertebrate proteins such as human HYOU1; T24H7.2, its C. elegans paralog T14G8.3, and HYOU1 are ER resident hsp70 family molecular chaperone homologs; the grp (glucose regulated protein) 170 family is a collection of related large hsp70 chaperones confined to the ER; members of this family are present in all eukaryotes, participating in a wide range of cellular functions.
                                              
Member of lists (Publications lists):
                                              Lund et al 2002 Aging time course                                 
                                              Fig2C heatshock, McCarroll et al 2004  SFig1-4                                     
                                              conserved w/ Drosoph, Romagnolo et al 2002  Fig2a heat                             
                                              shock, ViswanathanM et al 2005  S2 sir-2.1 regulated                               

T27E4.8 hsp-16 P W All gene names: hsp-16.1; hsp-16; T27E4.8; 5J568; CE14249; NM_072953; WBGene00002015; WP:CE14249 WormBase description: hsp-16.1 encodes a 16-kD heat shock protein (HSP) that is a member of the hsp16/hsp20/alphaB-crystallin (HSP16) family of heat shock proteins, and that is identical to the protein encoded by hsp-16.11; an hsp-16.1 reporter fusion, expressed broadly but most strongly in muscle and hypodermis, is induced solely in response to heat shock or other environmental stresses; expression is detectable in somatic tissues in post-gastrulation embryos, all larval stages, and in adults; HSP-16.1 is likely to function as a passive ligand temporarily preventing unfolded proteins from aggregating. WormBase CDS description: heat shock protein HSP16-1
                                              
Member of lists (Publications lists):
                                              Murphy et al 2003  Fig2 Class1                                    
                                              elongate lifespan, Romagnolo et al 2002  Fig2a heat                                
                                              shock, ViswanathanM et al 2005  S2 sir-2.1 regulated                               

Y46H3A.3 hsp-16.2 P W All gene names: hsp-16.2; Y46H3A.3; Y46H3A.D; 5C282; CE22002; NM_071106; WBGene00002016; WP:CE22002 WormBase description: hsp-16.2 encodes a 16-kD heat shock protein (HSP) that is a member of the hsp16/hsp20/alphaB-crystallin (HSP16) family of heat shock proteins; hsp-16.2 expression, strongest in intestine and pharynx, is induced in response to heat shock or other environmental stresses; HSP-16.2 has been shown to interact with intracellular human beta amyloid peptide, a primary component of the extracellular plaques found in Alzheimer's disease; HSP-16.2 is likely to function as a passive ligand temporarily preventing unfolded proteins from aggregating. WormBase CDS description: heat shock protein
                                              
Member of lists (Publications lists):
                                              Golden et al 2004, N2 differentially                              
                                              expressed gen, Golden et al 2004, daf-2 differentially                             
                                              expressed , Link et al 2003  T3 Abeta highly induced,                              
                                              Link et al 2003  T2 Abeta induced, Murphy et al 2003                               
                                              Fig2 Class1 elongate lifespan, Romagnolo et al 2002                                
                                              Fig2a heat shock, ViswanathanM et al 2005  S2 sir-2.1                              
                                              regulated