Murphy et al 2003 Fig2 Class1 elongate lifespan, 248 genes Gene list file name: Murphy2003.Fig2_Class1_elongate_lifespan.txt Type of gene identifier: Cosmid name Description: Murphy et al 2003 Fig2 Class1 elongate lifespan Organism: Caenorhabditis elegans (nematode) Gene list type: Experimental Gene name Source Gene ID All gene names WormBase description WormBase CDS description Proteome description Member of lists (Publications) Other annotations AC3.7 AC3.7 dod-15; ugt-1; AC3.7; 5K877; CE05137; NM_073270; WBGene00007072; WP:CE05137 UDP-glucuronosyltransferase Kwon et al 2004 T1 late-induction Ethanol-response, Murphy et al 2003 Fig2 Class1 elongate lifespan, ReichertK et al 2005 T1 xenobiotic induced UDP-gl, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, herm soma enriched genes, Reinke et al 2004, GO categories, Reinke et al 2004, list of genes in cluster B, ViswanathanM et al 2005 S2 sir-2.1 regulated B0213.12 B0213.12 cyp-34A7; B0213.12; 5E434; CE16783; NM_071700; WBGene00015042; WP:CE16783 cytochrome P450 Murphy et al 2003 Fig2 Class1 elongate lifespan B0213.15 B0213.15 ccp-34A9; cyp-34A9; dod-16; B0213.15; 5E446; CE30582; CE39545; CE39546; NM_071702; WBGene00015044; WP:CE30582; WP:CE39545; WP:CE39546 cytochrome P450 Murphy et al 2003 Fig2 Class1 elongate lifespan, ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S3 genes pass one-way ANOVA, Wang et al 2003 S4 Dauer Enriched, Wang et al 2003 S4 genes pass two-wayANOVA P0 B0218.8 B0218.8 clec-52; B0218.8; 4I932; CE06691; WBGene00015052; WP:CE06691 7TM chemoreceptor, clec family Murphy et al 2003 Fig2 Class1 elongate lifespan, ReichertK et al 2005 T2 xenobiotic induced C-type, Reinke et al 2004, herm soma enriched genes, ViswanathanM et al 2005 S2 daf-16 Resveratrol B0238.1 B0238.1 B0238.1; 5F718; CE07691; WBGene00015067; WP:CE07691 carboxylesterase Murphy et al 2003 Fig2 Class1 elongate lifespan, ReichertK et al 2005 T1 B0244.2 B0244.2 ida-1; B0244.2; B0244.2.1; B0244.2.2; 3G855; CE31867; NM_065844; WBGene00002048; WP:CE31867; ia2 ida-1 encodes a protein tyrosine phosphatase-like receptor, orthologous to the mammalian type I diabetes autoantigens IA-2 and phogrin that are expressed in dense core vesicles of neuroendocrine tissue and involved in regulated protein secretion; in C. elegans, IDA-1 appears to be required for regulating presynaptic neurotransmission and in particular, for the neuropeptidergic control of egg-laying; ida-1 interacts genetically with unc-31 and unc-64, which encode proteins required for dense core vesicle fusion and exocytosis; ida-1 expression is detected in a subset of neurons in the anterior nerve ring, the ventral nerve cord, the tail, and the vulva, including the VC vulval motoneurons and the HSN egg-laying neurons; ida-1 is also detected in the vulval uv1 cells, non-neuronal cells that contain neurosecretory-like vesicles. protein tyrosine phosphatase McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Murphy et al 2003 Fig2 Class1 elongate lifespan, Reinke et al 2004, list of genes in cluster A, Reinke et al 2004, list of genes in cluster order, ViswanathanM et al 2005 S2 sir-2.1 regulated B0286.3 B0286.3 B0286.3; 2E660; CE03863; WBGene00015116; WP:CE03863 This gene encodes a protein predicted by Eisenberg and coworkers, with 52% accuracy, to be mitochondrial. saicar synthetase/air carboxlyase McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Murphy et al 2003 Fig2 Class1 elongate lifespan, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, list of genes in cluster B, ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S6 removed genes of contamination C02A12.4 C02A12.4 lys-7; C02A12.4; 5D960; CE07828; NM_071571; WBGene00003096; WP:CE07828 lys-7 encodes an enzyme homologous to an antimicrobial lysozyme encoded by the LYS4 gene of the protozoan parasite Entamoeba histolytica; by homology, LYS-7 is predicted to function as an antimicrobial enzyme that hydrolyzes the 1,4-beta-linkages between N-acetyl-D-glucosamine and N-acetylmuramic acid in peptidoglycan heteropolymers of prokaryotic cell walls; in C. elegans, lys-7 expression is significantly upregulated in response to infection with the Gram-negative bacterium Serratia marcescens, indicating that LYS-7 likely plays a role in the innate immune response; constitutive expression of lys-7 mRNA is detected in the intestine and the intestinal valve cells. Murphy et al 2003 Fig2 Class1 elongate lifespan, Reinke et al 2004, herm soma enriched genes, ViswanathanM et al 2005 S2 sir-2.1 regulated, ViswanathanM et al 2005 S2 daf-16 Resveratrol C05C12.4 C05C12.4 C05C12.4; 4M12; CE39218; WBGene00007336; WP:CE39218 Murphy et al 2003 Fig2 Class1 elongate lifespan, Reinke et al 2004, list of genes in cluster A, Reinke et al 2004, list of genes in cluster order, ViswanathanM et al 2005 S2 daf-16 Resveratrol C05D9.1 C05D9.1 snx-1; C05D9.1; C05D9.1.1; C05D9.1.2; C05D9.1.3; CE07927; NM_075815; SNX1; WBGene00004927; WP:CE07927; XB751 McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Murphy et al 2003 Fig2 Class1 elongate lifespan, ViswanathanM et al 2005 S2 sir-2.1 regulated C05E4.9 C05E4.9 gei-7; C05E4.9; C05E4.9a.1; C05E4.9a.2; C05E4.9a.3; C05E4.9b.1; C05E4.9b.2; 5B204; CE23521; CE32565; NM_070905; WBGene00001564; WP:CE23521; WP:CE32565 gei-7 encodes a predicted isocitrate lyase/malate synthase, an enzyme known to function in the glyoxylate cycle; GEI-7 was identified in a screen for proteins that interact with GEX-3, a homolog of human HEM-2 which is required for embryonic development; GEI-7 is required for embryonic morphogenesis and appears to act downstream of DAF-16 to influence lifespan. McCarroll et al 2004 SFig5 conserved w/ yeast, Murphy et al 2003 Fig2 Class1 elongate lifespan, ViswanathanM et al 2005 S2 sir-2.1 regulated C06B3.4 C06B3.4 dod-8; stdh-1; C06B3.4; 5O389; CE07961; NM_074048; WBGene00007363; WP:CE07961 This gene encodes a protein predicted by Eisenberg and coworkers, with 68% accuracy, to be mitochondrial. estradiol 17 beta-dehydrogenase Murphy et al 2003 Fig2 Class1 elongate lifespan, ViswanathanM et al 2005 S2 sir-2.1 regulated C08A9.1 C08A9.1 sod-3; C08A9.1; CE08002; MnSOD; NM_078363; WBGene00004932; WP:CE08002; XR707 sod-3 encodes a iron/manganese superoxide dismutase, predicted to be mitochondrial, that might defend against oxidative stress and promote normal lifespan; sod-3 mRNA levels are diminished by mutation of daf-16, and heterologously expressed SOD-3 in E. coli protects against methyl viologen-induced oxidative stress. superoxide dismutase Jones et al 2001 T2 lifespan and Dauer, Lund et al 2002 Fig4 Mount 15, McElwee et al 2003 T1 targets of daf-16, McElwee et al 2003 Fig4 daf-16 target lifspan, Murphy et al 2003 Fig2 Class1 elongate lifespan, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, mixed oogenesis soma, ViswanathanM et al 2005 S2 daf-16 Resveratrol, ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S6 removed genes of contamination C08B6.4 C08B6.4 C08B6.4; 5K597; CE05241; CE37189; WBGene00007425; WP:CE05241; WP:CE37189 chitinase Murphy et al 2003 Fig2 Class1 elongate lifespan, ViswanathanM et al 2005 S2 sir-2.1 regulated C08E3.4 C08E3.4 C08E3.4; 2B898; CE32119; WBGene00015596; WP:CE32119 Lund et al 2002 Fig4 Mount 15, Murphy et al 2003 Fig2 Class1 elongate lifespan, ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S6 removed genes of contamination C08E3.6 C08E3.6 C08E3.6; 2B902; CE08009; WBGene00015598; WP:CE08009 This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins; this gene's encoded protein also contains an FTH/DUF38 motif, which may also mediate protein-protein interaction. Murphy et al 2003 Fig2 Class1 elongate lifespan C08E8.4 C08E8.4 C08E8.4; 5S845; CE17378; WBGene00007440; WP:CE17378 Kwon et al 2004 T1 late-repression Ethanol-respon, Murphy et al 2003 Fig2 Class1 elongate lifespan C08F11.11 C08F11.11 C08F11.11; 4O410; CE17388; WBGene00007458; WP:CE17388 Murphy et al 2003 Fig2 Class1 elongate lifespan, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, herm soma enriched genes, ViswanathanM et al 2005 S2 sir-2.1 regulated, ViswanathanM et al 2005 S2 daf-16 Resveratrol C08F11.3 C08F11.3 C08F11.3; 4O385; CE35387; WBGene00007452; WP:CE35387 Kwon et al 2004 T1 late-repression Ethanol-respon, Murphy et al 2003 Fig2 Class1 elongate lifespan C13B9.1 C13B9.1 C13B9.1; C13B9.1.1; C13B9.1.2; 3H719; CE32795; WBGene00015732; WP:CE32795 Murphy et al 2003 Fig2 Class1 elongate lifespan, Reinke et al 2004, list of genes in cluster A, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, wt herm vs wt male enriched gen C15H9.1 C15H9.1 nnt-1; C15H9.1; CE08176; NM_076627; WBGene00003778; WP:CE08176; XG745 nnt-1 encodes a proton-pumping nicotinamide nucleotide transhydrogenase predicted to be mitochondrial. NAD(P) transhydrogenase, mitochondrial Murphy et al 2003 Fig2 Class1 elongate lifespan, ViswanathanM et al 2005 S2 sir-2.1 regulated, ViswanathanM et al 2005 S2 daf-16 Resveratrol, Wang et al 2003 S5 genes common to feeding ANOVA, Wang et al 2003 S3 genes pass one-way ANOVA C17G1.4 C17G1.4 C17G1.4; CE08283; CE37318; WBGene00007651; WP:CE08283; WP:CE37318; XK546 Murphy et al 2003 Fig2 Class1 elongate lifespan, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, mixed oogenesis soma, Reinke et al 2004, GO categories C17G10.5 C17G10.5 lys-8; C17G10.5; 2F877; CE06846; NM_062682; WBGene00003097; WP:CE06846 Murphy et al 2003 Fig2 Class1 elongate lifespan, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, list of genes in cluster C C18A11.1 C18A11.1 C18A11.1; CE04032; WBGene00015947; WP:CE04032; XI687 Lund et al 2002 Fig4 Mount 15, Murphy et al 2003 Fig2 Class1 elongate lifespan, Reinke et al 2004, IVb male soma enriched genes, ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S3 genes pass one-way ANOVA, Wang et al 2003 S4 Dauer Enriched, Wang et al 2003 S4 genes pass two-wayANOVA P0 C18D4.8 C18D4.8 C18D4.8; 5S26; CE31882; WBGene00007677; WP:CE31882 This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins. Murphy et al 2003 Fig2 Class1 elongate lifespan, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, herm soma enriched genes C24B9.9 C24B9.9 dod-3; C24B9.9; 5D208; CE17451; NM_071341; WBGene00016052; WP:CE17451 Kwon et al 2004 T1 late-repression Ethanol-respon, Murphy et al 2003 Fig2 Class1 elongate lifespan, Reinke et al 2004, IVb male soma enriched genes, Shen et al 2005 T1 hif-1 depend hypoxia, Wang et al 2003 S3 genes pass one-way ANOVA, Wang et al 2003 S4 Dauer Enriched, Wang et al 2003 S4 genes pass two-wayANOVA P0 C25E10.8 C25E10.8 C25E10.8; 5J528; CE06870; WBGene00016097; WP:CE06870 Murphy et al 2003 Fig2 Class1 elongate lifespan, ViswanathanM et al 2005 S2 sir-2.1 regulated, ViswanathanM et al 2005 S2 daf-16 Resveratrol, Wang et al 2003 S3 genes pass one-way ANOVA, Wang et al 2003 S4 Dauer Enriched, Wang et al 2003 S4 genes pass two-wayANOVA P0 C25E10.9 C25E10.9 isl-2; swm-1; C25E10.9; C25E10.9b.1; C25E10.9b.2; C25E10.9b.3; C25E10.9b.4; 5J530; CE06871; CE32805; NM_072945; NM_182364; WBGene00016098; WBGene00023417; WP:CE06871; WP:CE32805 Murphy et al 2003 Fig2 Class1 elongate lifespan, Reinke et al 2004, mixed sperm soma, Reinke et al 2004, fem3 enriched genes, ViswanathanM et al 2005 S2 sir-2.1 regulated C26C6.3 C26C6.3 nas-36; C26C6.3; 1I107; CE38281; NM_059708; WBGene00003552; WP:CE38281 zinc metalloprotease Murphy et al 2003 Fig2 Class1 elongate lifespan, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, list of genes in cluster C, ViswanathanM et al 2005 S2 daf-16 Resveratrol, ViswanathanM et al 2005 S2 Resveratrol regulate WT, Wang et al 2003 S3 genes pass one-way ANOVA, Wang et al 2003 S4 genes pass two-wayANOVA P0, Wang et al 2003 S4 LateList C27H5.2 C27H5.2 C27H5.2; 2H449; CE27098; CE29191; CE32150; CE32151; WBGene00016172; WP:CE27098; WP:CE29191; WP:CE32150; WP:CE32151 Jones et al 2001 Dauer specific genes P<0.05, Murphy et al 2003 Fig2 Class1 elongate lifespan, ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S7 SAGE genes in the dataset, Wang et al 2003 S8 SAGE genes in the dauer exit C30G7.1 C30G7.1 hil-1; C30G7.1; H1.X; 5P431; CE08476; NM_074279; WBGene00001852; WP:CE08476 histone H1 like Murphy et al 2003 Fig2 Class1 elongate lifespan C32B5.3 C32B5.3 C32B5.3; 2B267; CE08511; WBGene00016296; WP:CE08511 Murphy et al 2003 Fig2 Class1 elongate lifespan, Reinke et al 2004, wt herm vs wt herm enriched gen C34C6.7 C34C6.7 C34C6.7; 2I997; CE03055; WBGene00007919; WP:CE03055 Lund et al 2002 Fig1 aging-regulated genes, Lund et al 2002 Fig4 Mount 15, Murphy et al 2003 Fig2 Class1 elongate lifespan, Reinke et al 2004, fem3 enriched genes, Reinke et al 2004, mixed sperm soma, Romagnolo et al 2002 Fig3b Unkown, Wang et al 2003 S3 genes pass one-way ANOVA, Wang et al 2003 S4 genes pass two-wayANOVA P0, Wang et al 2003 S4 Dauer Enriched C34D10.2 C34D10.2 C34D10.2; CE37615; WBGene00016407; WP:CE37615; XI645 Cys(3)His finger protein (D. melanogaster) McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Murphy et al 2003 Fig2 Class1 elongate lifespan C37H5.2 C37H5.2 C37H5.2; 5F327; CE30737; WBGene00016506; WP:CE30737 Kwon et al 2004 T1 late-induction Ethanol-response, Lund et al 2002 Fig4 Mount 15, Murphy et al 2003 Fig2 Class1 elongate lifespan, ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S3 genes pass one-way ANOVA, Wang et al 2003 S4 Dauer Enriched, Wang et al 2003 S4 genes pass two-wayANOVA P0 C40H1.5 C40H1.5 C40H1.5; 3K419; CE00113; WBGene00008040; WP:CE00113 Transthyretin-like family Murphy et al 2003 Fig2 Class1 elongate lifespan, ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S6 removed genes of contamination C40H5.1 C40H5.1 nspa-9; C40H5.1; CE08649; WBGene00043187; WP:CE08649 Murphy et al 2003 Fig2 Class1 elongate lifespan, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, spermatogenesis enriched genes, Reinke et al 2004, wt herm vs wt herm enriched gen, Reinke et al 2004, fem3 enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, wt males vs glp4 male enriched , Reinke et al 2004, list of genes in cluster D, Reinke et al 2004, shared sperm, ViswanathanM et al 2005 S2 daf-16 Resveratrol, ViswanathanM et al 2005 S2 sir-2.1 regulated C44E12.2 C44E12.2 C44E12.2; WBGene00043191 Murphy et al 2003 Fig2 Class1 elongate lifespan C44H9.5 C44H9.5 C44H9.5; 5N330; CE05421; WBGene00008100; WP:CE05421 Murphy et al 2003 Fig2 Class1 elongate lifespan C45B11.3 C45B11.3 dhs-18; C45B11.3; C45B11.3.1; C45B11.3.2; 5L526; CE05427; NM_073411; WBGene00000981; WP:CE05427 alcohol dehydrogenase Murphy et al 2003 Fig2 Class1 elongate lifespan, Reinke et al 2004, list of genes in cluster A, Reinke et al 2004, list of genes in cluster order C45G7.3 C45G7.3 C45G7.3; 4D229; CE24850; WBGene00016670; WP:CE24850 Kwon et al 2004 T1 late-repression Ethanol-respon, Lund et al 2002 Fig4 Mount 15, Murphy et al 2003 Fig2 Class1 elongate lifespan, Romagnolo et al 2002 Fig3b Unkown, ViswanathanM et al 2005 S2 sir-2.1 regulated C46F4.2 C46F4.2 acs-17; dod-9; C46F4.2; C46F4.2.1; C46F4.2.2; CE30907; NM_076592; WBGene00016716; WP:CE30907; XG556 long-chain-fatty-acid coA ligase McCarroll et al 2004 SFig5 conserved w/ yeast, Murphy et al 2003 Fig2 Class1 elongate lifespan, Reinke et al 2004, list of genes in cluster A, Reinke et al 2004, list of genes in cluster order, ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S3 genes pass one-way ANOVA, Wang et al 2003 S4 genes pass two-wayANOVA P0, Wang et al 2003 S4 Dauer Enriched C46H11.2 C46H11.2 C46H11.2; 1F619; CE08784; WBGene00016728; WP:CE08784 This gene encodes a protein predicted by Eisenberg and coworkers, with 52% accuracy, to be mitochondrial. Baugh et al 2005, validated PAL-1 target genes, Baugh et al 2005, PAL-1 target genes, McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Murphy et al 2003 Fig2 Class1 elongate lifespan, Reinke et al 2004, list of genes in cluster A, Reinke et al 2004, list of genes in cluster order, ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S3 genes pass one-way ANOVA, Wang et al 2003 S4 Climbing, Wang et al 2003 S4 genes pass two-wayANOVA P0 C50F7.10 C50F7.10 C50F7.10; 4I512; CE04248; WBGene00016848; WP:CE04248 glycosyl hydrolase Murphy et al 2003 Fig2 Class1 elongate lifespan, Reinke et al 2004, list of genes in cluster A, Reinke et al 2004, list of genes in cluster order, Wang et al 2003 S3 genes pass one-way ANOVA, Wang et al 2003 S4 Dauer Enriched, Wang et al 2003 S4 genes pass two-wayANOVA P0 C50F7.2 C50F7.2 clx-1; col-4; C50F7.2; 4I499; CE39705; NM_068868; WBGene00000551; WP:CE39705 clx-1 encodes a protein that contains 23 copies of a 15 amino acid repeat, possibly derived from a collagen triplet; there is no transcript evidence for this locus. Murphy et al 2003 Fig2 Class1 elongate lifespan, ViswanathanM et al 2005 S2 sir-2.1 regulated, ViswanathanM et al 2005 S2 daf-16 Resveratrol C50F7.5 C50F7.5 C50F7.5; 4I491; CE04243; WBGene00016845; WP:CE04243 GuhaThakurta et al 2002 T1 upregu on heat stress, Murphy et al 2003 Fig2 Class1 elongate lifespan C52D10.1 C52D10.1 C52D10.1; 4S131; CE17586; WBGene00016875; WP:CE17586 Murphy et al 2003 Fig2 Class1 elongate lifespan, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, list of genes in cluster C, Wang et al 2003 S3 genes pass one-way ANOVA, Wang et al 2003 S4 Dauer Enriched, Wang et al 2003 S4 genes pass two-wayANOVA P0 C52D10.2 C52D10.2 C52D10.2; CE17587; WBGene00016876; WP:CE17587 Murphy et al 2003 Fig2 Class1 elongate lifespan, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, list of genes in cluster B, Wang et al 2003 S3 genes pass one-way ANOVA, Wang et al 2003 S4 Dauer Enriched, Wang et al 2003 S4 genes pass two-wayANOVA P0 C52E4.1 C52E4.1 cpr-1; gcp-1; C52E4.1; 5M457; CE31896; CPROT/1; NM_073601; WBGene00000781; WP:CE31896 cpr-1 encodes a cysteine protease of the cathepsin B-like cysteine protease family; cpr-1 appears to be required for embryogenesis; cpr-1 is specifically expressed in the gut of all stages except the embryo and around developing embryos in the gonad; expression of cpr-1 is regulated by three promoter GATA motifs. cathepsin-like cysteine protease Golden et al 2004, N2 differentially expressed gen, Murphy et al 2003 Fig2 Class1 elongate lifespan, ViswanathanM et al 2005 S2 sir-2.1 regulated, ViswanathanM et al 2005 S2 daf-16 Resveratrol C53B7.3 C53B7.3 C53B7.3; CE06973; WBGene00016894; WP:CE06973; XH463 Lund et al 2002 Fig1 aging-regulated genes, Murphy et al 2003 Fig2 Class1 elongate lifespan, ViswanathanM et al 2005 S2 sir-2.1 regulated, ViswanathanM et al 2005 S2 daf-16 Resveratrol C54C8.9 C54C8.9 nlp-39; C54C8.9; 1N53; CE08971; WBGene00008295; WP:CE08971 Murphy et al 2003 Fig2 Class1 elongate lifespan, ViswanathanM et al 2005 S2 sir-2.1 regulated, ViswanathanM et al 2005 S2 daf-16 Resveratrol C54D10.1 C54D10.1 cdr-2; C54D10.1; 5M894; CE05497; NM_073713; WBGene00008296; WP:CE05497 glutathione S-transferase Kwon et al 2004 T1 late-induction Ethanol-response, Murphy et al 2003 Fig2 Class1 elongate lifespan, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, list of genes in cluster B, ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S4 TransientList, Wang et al 2003 S3 genes pass one-way ANOVA, Wang et al 2003 S4 genes pass two-wayANOVA P0 C54D10.3 C54D10.3 C54D10.3; C54D10.3.1; C54D10.3.2; 5M899; CE05499; WBGene00008298; WP:CE05499 Murphy et al 2003 Fig2 Class1 elongate lifespan, Reinke et al 2004, list of genes in cluster A, Reinke et al 2004, list of genes in cluster order, ViswanathanM et al 2005 S2 sir-2.1 regulated C54D10.7 C54D10.7 C54D10.7; 5M916; CE05503; WBGene00008301; WP:CE05503 Murphy et al 2003 Fig2 Class1 elongate lifespan C55C3.4 C55C3.4 C55C3.4; 4G442; CE06991; WBGene00016954; WP:CE06991 tyrosine-protein kinase Murphy et al 2003 Fig2 Class1 elongate lifespan, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, spermatogenesis enriched genes, Reinke et al 2004, wt herm vs wt herm enriched gen, Reinke et al 2004, fem3 enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, wt males vs glp4 male enriched , Reinke et al 2004, GO categories, Reinke et al 2004, list of genes in cluster D, Reinke et al 2004, shared sperm, ViswanathanM et al 2005 S2 sir-2.1 regulated C56A3.2 C56A3.2 C56A3.2; C56A3.2.1; C56A3.2.2; 5O10; CE09030; WBGene00008341; WP:CE09030 Transthyretin-like family Murphy et al 2003 Fig2 Class1 elongate lifespan, Reinke et al 2004, list of genes in cluster A, Reinke et al 2004, list of genes in cluster order, ViswanathanM et al 2005 S2 sir-2.1 regulated CC8.2 CC8.2 CC8.2; CC8.2a.1; CC8.2a.2; 4E410; CE20615; CE23615; WBGene00016987; WP:CE20615; WP:CE23615 McCarroll et al 2004 SFig5 conserved w/ yeast, Murphy et al 2003 Fig2 Class1 elongate lifespan, Shen et al 2005 T1 hif-1 depend hypoxia, ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S3 genes pass one-way ANOVA, Wang et al 2003 S4 Dauer Enriched, Wang et al 2003 S4 genes pass two-wayANOVA P0 D1025.4 D1025.4 nspc-20; D1025.4; CE17612; WBGene00008356; WP:CE17612; XP148 Kwon et al 2004 T1 late-repression Ethanol-respon, Murphy et al 2003 Fig2 Class1 elongate lifespan, Reinke et al 2004, mixed sperm soma, Reinke et al 2004, fem3 enriched genes, ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S4 Climbing, Wang et al 2003 S3 genes pass one-way ANOVA, Wang et al 2003 S4 genes pass two-wayANOVA P0 D1086.3 D1086.3 D1086.3; 5O573; CE09061; WBGene00008390; WP:CE09061 Murphy et al 2003 Fig2 Class1 elongate lifespan, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, list of genes in cluster C, Reinke et al 2004, mixed oogenesis soma, Reinke et al 2004, wt herm vs wt herm enriched gen, ViswanathanM et al 2005 S2 sir-2.1 regulated E01A2.8 E01A2.8 E01A2.8; 1E714; CE24875; WBGene00017090; WP:CE24875 The E01A2.8 gene encodes one of five paraoxonase-like proteins; it is homologous to the human PARAOXONASE 1 gene (PON1, OMIM:168820), which in some allelic forms is associated with susceptibility to coronary artery disease. Murphy et al 2003 Fig2 Class1 elongate lifespan, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, list of genes in cluster B, ViswanathanM et al 2005 S2 sir-2.1 regulated, ViswanathanM et al 2005 S2 daf-16 Resveratrol, Wang et al 2003 S6 removed genes of contamination E01G4.3 E01G4.3 E01G4.3; 2N752; CE09110; WBGene00008446; WP:CE09110 Murphy et al 2003 Fig2 Class1 elongate lifespan, Reinke et al 2004, list of genes in cluster A, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, wt herm vs wt herm enriched gen, ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S3 genes pass one-way ANOVA, Wang et al 2003 S4 genes pass two-wayANOVA P0, Wang et al 2003 S4 Dauer Enriched F02H6.5 F02H6.5 F02H6.5; 4O987; CE17629; WBGene00008538; WP:CE17629 McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Murphy et al 2003 Fig2 Class1 elongate lifespan, ViswanathanM et al 2005 S2 sir-2.1 regulated F08B1.1 F08B1.1 nrf-2; vhp-1; F08B1.1; F08B1.1a.1; F08B1.1a.2; F08B1.1a.3; F08B1.1c.1; F08B1.1c.2; F08B1.1c.3; 2F629; CE27918; CE27919; CE32357; NM_062596; NM_062597; NM_182126; WBGene00006923; WP:CE27918; WP:CE27919; WP:CE32357 protein tyrosine phosphatase Kwon et al 2004 T1 late-induction Ethanol-response, Murphy et al 2003 Fig2 Class1 elongate lifespan, ViswanathanM et al 2005 S2 sir-2.1 regulated F08B12.4 F08B12.4 F08B12.4; F08B12.4.1; F08B12.4.2; CE26708; WBGene00008572; WP:CE26708; XM26 Murphy et al 2003 Fig2 Class1 elongate lifespan, Reinke et al 2004, mixed sperm soma, Reinke et al 2004, fem3 enriched genes, ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S6 removed genes of contamination F09B12.3 F09B12.3 F09B12.3; CE31469; WBGene00008607; WP:CE31469; XP714 Jones et al 2001 Non dauer genes P<0.05, Murphy et al 2003 Fig2 Class1 elongate lifespan, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, list of genes in cluster C, Wang et al 2003 S4 Early genes, Wang et al 2003 S3 genes pass one-way ANOVA, Wang et al 2003 S4 genes pass two-wayANOVA P0 F09F7.6 F09F7.6 F09F7.6; 3G640; CE01238; WBGene00017303; WP:CE01238 Murphy et al 2003 Fig2 Class1 elongate lifespan, ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S3 genes pass one-way ANOVA, Wang et al 2003 S4 Dauer Enriched, Wang et al 2003 S4 genes pass two-wayANOVA P0 F09F7.7 F09F7.7 F09F7.7; 3G644; CE30655; CE30656; WBGene00017304; WP:CE30655; WP:CE30656 McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Murphy et al 2003 Fig2 Class1 elongate lifespan, Reinke et al 2004, wt herm vs wt male enriched gen, Wang et al 2003 S5 genes common to feeding ANOVA, Wang et al 2003 S3 genes pass one-way ANOVA F10D2.11 F10D2.11 ugt-41; F10D2.11; 5H640; CE36127; WBGene00017336; WP:CE36127 7TM chemoreceptor, ugt family Murphy et al 2003 Fig2 Class1 elongate lifespan, ViswanathanM et al 2005 S2 sir-2.1 regulated, ViswanathanM et al 2005 S2 daf-16 Resveratrol F10D2.9 F10D2.9 fat-7; F10D2.9; 5H632; CE09320; NM_072413; WBGene00001399; WP:CE09320 fat-7 encodes an essential delta-9 fatty acid desaturase that is required for the synthesis of monounsaturated fatty acids; fat-7 can substitute for the functions of the other two fatty acid desaturases, fat-5 and fat-6; RNA interference has shown that fat-7 is required for viability and normal growth. stearoyl-CoA desaturase Murphy et al 2003 Fig2 Class1 elongate lifespan F11A5.12 F11A5.12 dod-10; stdh-2; F11A5.12; 5Q705; CE15790; NM_074691; WBGene00008678; WP:CE15790 This gene encodes a protein predicted by Eisenberg and coworkers, with 68% accuracy, to be mitochondrial. Estradiol 17-beta-dehydrogenase Murphy et al 2003 Fig2 Class1 elongate lifespan F12A10.7 F12A10.7 F12A10.7; 2F784; CE39352; WBGene00017396; WP:CE39352 Murphy et al 2003 Fig2 Class1 elongate lifespan, ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S3 genes pass one-way ANOVA, Wang et al 2003 S4 Dauer Enriched, Wang et al 2003 S4 genes pass two-wayANOVA P0 F13D11.4 F13D11.4 F13D11.4; CE37632; WBGene00017429; WP:CE37632; XG452 dihydroflavonol-4-reductase (maize, petunia, tomato) McCarroll et al 2004 SFig5 conserved w/ yeast, Murphy et al 2003 Fig2 Class1 elongate lifespan, Wang et al 2003 S3 genes pass one-way ANOVA, Wang et al 2003 S4 LateList, Wang et al 2003 S4 genes pass two-wayANOVA P0 F13H8.5 F13H8.5 F13H8.5; 2G544; CE36821; WBGene00017438; WP:CE36821 F13H8.5 encodes a protein with a domain of unknown function (DB; IPR002602) that is found in several worm proteins, and a glutamine/asparagine-rich domain. Phospholipase ADRAB-B (Rabbit) Murphy et al 2003 Fig2 Class1 elongate lifespan F15A2.2 F15A2.2 tre-4; F15A2.2; CE35484; NM_077848; WBGene00006610; WP:CE35484; XO93 trehalase precursor Murphy et al 2003 Fig2 Class1 elongate lifespan, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, list of genes in cluster C, ViswanathanM et al 2005 S2 daf-16 Resveratrol F15A4.8 F15A4.8 F15A4.8; 2M766; CE15845; CE32863; WBGene00008842; WP:CE15845; WP:CE32863 chitinase Murphy et al 2003 Fig2 Class1 elongate lifespan, ViswanathanM et al 2005 S2 daf-16 Resveratrol F15B9.1 F15B9.1 far-3; F15B9.1; 5N476; CE09406; NM_073850; WBGene00001387; WP:CE09406 O.volvulus antigen peptide like Murphy et al 2003 Fig2 Class1 elongate lifespan, ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S3 genes pass one-way ANOVA, Wang et al 2003 S4 LateList, Wang et al 2003 S4 genes pass two-wayANOVA P0 F15E6.4 F15E6.4 F15E6.4; 4F57; CE16993; WBGene00017485; WP:CE16993 Murphy et al 2003 Fig2 Class1 elongate lifespan, ViswanathanM et al 2005 S2 sir-2.1 regulated F15E6.8 F15E6.8 F15E6.8; 4F54; CE16997; WBGene00017488; WP:CE16997 Murphy et al 2003 Fig2 Class1 elongate lifespan, Reinke et al 2004, wt herm vs wt herm enriched gen, Reinke et al 2004, IVb male soma enriched genes F16D3.5 F16D3.5 F16D3.5; WBGene00008888 Lund et al 2002 Fig2D mariner, Murphy et al 2003 Fig2 Class1 elongate lifespan, Reinke et al 2004, list of genes in cluster A, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, mixed sperm soma, Reinke et al 2004, fem3 enriched genes, ViswanathanM et al 2005 S2 sir-2.1 regulated F16H6.7 F16H6.7 F16H6.7; 5S682; CE18603; WBGene00008897; WP:CE18603 Jones et al 2001 Dauer specific genes P<0.05, Murphy et al 2003 Fig2 Class1 elongate lifespan, Reinke et al 2004, list of genes in cluster A, Reinke et al 2004, list of genes in cluster order, ViswanathanM et al 2005 S2 daf-16 Resveratrol, Wang et al 2003 S8 SAGE genes in the dauer exit F17A9.5 F17A9.5 F17A9.5; 5G592; CE09449; WBGene00017537; WP:CE09449 Murphy et al 2003 Fig2 Class1 elongate lifespan, ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S6 removed genes of contamination F17B5.1 F17B5.1 F17B5.1; 1N779; CE15865; WBGene00008905; WP:CE15865 McElwee et al 2003 T1 targets of daf-16, Murphy et al 2003 Fig2 Class1 elongate lifespan, Reinke et al 2004, list of genes in cluster A, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, herm soma enriched genes, Reinke et al 2004, GO categories, ViswanathanM et al 2005 S2 daf-16 Resveratrol F18E3.7 F18E3.7 F18E3.7; 5H914; CE07083; CE32864; WBGene00017565; WP:CE07083; WP:CE32864 D-amino acid oxidase Murphy et al 2003 Fig2 Class1 elongate lifespan, Reinke et al 2004, list of genes in cluster A, Reinke et al 2004, list of genes in cluster order, ViswanathanM et al 2005 S2 sir-2.1 regulated F19H8.1 F19H8.1 tps-2; F19H8.1; CE37507; NM_064634; WBGene00006603; WP:CE37507 tps-2 encodes one of two trehalose-6-phosphate synthase proteins in C. elegans, and RNAi of both enzymes leads to a more than 90% reduction decrease in trehalose levels, but does not appear to affect viability or development; the tps-2 mRNA is expressed throughout development. trehalose phosphate synthase McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Murphy et al 2003 Fig2 Class1 elongate lifespan F21C10.10 F21C10.10 F21C10.10; F21C10.10.1; F21C10.10.2; 5J577; CE30758; WBGene00017659; WP:CE30758 Kwon et al 2004 T1 late-repression Ethanol-respon, Murphy et al 2003 Fig2 Class1 elongate lifespan, Reinke et al 2004, mixed sperm soma, Reinke et al 2004, fem3 enriched genes, ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S5 genes common to feeding ANOVA, Wang et al 2003 S3 genes pass one-way ANOVA F21F3.3 F21F3.3 F21F3.3; 1F471; CE09533; WBGene00017673; WP:CE09533 protein-S isoprenylsysteine O-methyltransferase McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Murphy et al 2003 Fig2 Class1 elongate lifespan, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, spermatogenesis enriched genes, Reinke et al 2004, fem3 enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, wt males vs glp4 male enriched , Reinke et al 2004, list of genes in cluster D, Reinke et al 2004, shared sperm, Wang et al 2003 S3 genes pass one-way ANOVA, Wang et al 2003 S4 genes pass two-wayANOVA P0, Wang et al 2003 S4 Dauer Enriched F21F3.5 F21F3.5 tmr-2; unc-38; F21F3.5; 1F466; CE24908; NM_059071; WBGene00006774; WP:CE24908 unc-38 encodes a nicotinic acetylcholine receptor (nAChR) alpha subunit; UNC-38 is required for normal locomotion and egg-laying, and functions as a subunit of a ligand-gated ion channel that likely mediates fast actions of acetylcholine at neuromuscular junctions and in the nervous system; when coexpressed with UNC-29 and LEV-1, non-alpha nAChR subunits, the resulting multimer can form levamisole-gated channels; UNC-38 is expressed postsynaptically in muscles and neurons where it colocalizes with TAX-6, and with ACR-8, ACR-12, and UNC-29, respectively. ligand-gated ionic channel McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Murphy et al 2003 Fig2 Class1 elongate lifespan, Reinke et al 2004, list of genes in cluster A, Reinke et al 2004, list of genes in cluster order, ViswanathanM et al 2005 S2 sir-2.1 regulated F23B2.5 F23B2.5 flp-1; F23B2.5; 4J909; CE09585; CE32045; CE32046; NM_069191; NM_182277; NM_182278; WBGene00001444; WP:CE09585; WP:CE32045; WP:CE32046 flp-1 can encode up to seven distinct, yet highly similar, FMRFamide-related peptides (FaRPs), small neuromodulatory peptides that are characterized by a C-terminal Arg-Phe-amide motif; in C. elegans, FLP-1 peptides are required for regulation of several behaviors, including well-coordinated, sinusoidal movement and the transition between active and inactive states of egg-laying; receptors for the FLP-1 peptides have not yet been identified, but genetic studies indicate that FLP-1 peptides may act through G-protein coupled receptors; flp-1 mRNAs are detected at all developmental stages, and a FLP-1 translational reporter fusion detects expression in the anteriorly positioned neurons AVK, AVA, AVE, RIG, RMG, AIY, AIA, and M5 McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Murphy et al 2003 Fig2 Class1 elongate lifespan, Reinke et al 2004, list of genes in cluster A, Reinke et al 2004, list of genes in cluster order, ViswanathanM et al 2005 S2 sir-2.1 regulated F26D11.2 F26D11.2 F26D11.2; 5I435; CE17706; WBGene00017819; WP:CE17706 Murphy et al 2003 Fig2 Class1 elongate lifespan, Reinke et al 2004, mixed sperm soma, Reinke et al 2004, fem3 enriched genes, ViswanathanM et al 2005 S2 daf-16 Resveratrol F28A12.4 F28A12.4 F28A12.4; F28A12.4.1; F28A12.4.2; 5J122; CE09738; WBGene00017881; WP:CE09738 peptidase Kwon et al 2004 T1 late-repression Ethanol-respon, Murphy et al 2003 Fig2 Class1 elongate lifespan, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, GO categories, Reinke et al 2004, herm soma enriched genes, ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S3 genes pass one-way ANOVA, Wang et al 2003 S4 Climbing, Wang et al 2003 S4 genes pass two-wayANOVA P0 F28D1.3 F28D1.3 dod-2; thn-1; F28D1.3; 4N143; CE05743; NM_069959; WBGene00009213; WP:CE05743 Arabidopsis pathogenesis-related protein 5 like Murphy et al 2003 Fig2 Class1 elongate lifespan, ReichertK et al 2005 T3 xenobiotic downregulated, ViswanathanM et al 2005 S2 sir-2.1 regulated F28D1.5 F28D1.5 thn-2; F28D1.5; 4N149; CE05745; NM_069961; WBGene00009215; WP:CE05745 Arabidopsis pathogenesis-related protein 5 like Golden et al 2004, N2 differentially expressed gen, Golden et al 2004, daf-2 differentially expressed , Golden et al 2004, N2 vs daf-2 age different gene, Jones et al 2001 Non dauer genes P<0.05, Jones et al 2001 T3 20 most abundant Mixed-stage, Murphy et al 2003 Fig2 Class1 elongate lifespan, ReichertK et al 2005 T3 xenobiotic downregulated, ViswanathanM et al 2005 S2 sir-2.1 regulated F28F8.2 F28F8.2 acs-2; F28F8.2; F28F8.2.1; F28F8.2.2; CE09756; NM_074468; WBGene00009221; WP:CE09756 long-chain-fatty-acid-CoA ligase Kwon et al 2004 T1 late-repression Ethanol-respon, Murphy et al 2003 Fig2 Class1 elongate lifespan, ReichertK et al 2005 T3 xenobiotic downregulated, ViswanathanM et al 2005 S2 sir-2.1 regulated F31F4.7 F31F4.7 ugt-42; F31F4.7; 5B127; CE36837; WBGene00017959; WP:CE36837 7TM chemoreceptor, ugt family Murphy et al 2003 Fig2 Class1 elongate lifespan, ViswanathanM et al 2005 S2 sir-2.1 regulated F32A5.4 F32A5.4 F32A5.4; F32A5.4a.1; F32A5.4a.2; 2H519; CE01274; CE32640; WBGene00017970; WP:CE01274; WP:CE32640 Immunodominant antigen Murphy et al 2003 Fig2 Class1 elongate lifespan, Reinke et al 2004, list of genes in cluster A, Reinke et al 2004, list of genes in cluster order, Wang et al 2003 S3 genes pass one-way ANOVA, Wang et al 2003 S4 Dauer Enriched, Wang et al 2003 S4 genes pass two-wayANOVA P0 F32A5.5 F32A5.5 aqp-1; dod-4; F32A5.5; F32A5.5b.1; F32A5.5b.2; 2H526; CE01275; CE29304; NM_063109; NM_182133; WBGene00000169; WP:CE01275; WP:CE29304 Kwon et al 2004 T1 late-repression Ethanol-respon, Murphy et al 2003 Fig2 Class1 elongate lifespan, ReichertK et al 2005 T3 xenobiotic downregulated, Reinke et al 2004, list of genes in cluster A, Reinke et al 2004, list of genes in cluster order F35D11.11 F35D11.11 F35D11.11; 2E918; CE33068; CE39730; CE39731; CE39732; WBGene00018051; WP:CE33068; WP:CE39730; WP:CE39731; WP:CE39732 Murphy et al 2003 Fig2 Class1 elongate lifespan, ViswanathanM et al 2005 S2 sir-2.1 regulated F36D3.9 F36D3.9 cpr-2; F36D3.9; 5R14; CE30347; CPROT/2; NM_074785; WBGene00000782; WP:CE30347 cysteine protease Bishop et al 2004 T4 57 vhl-1 depend hif-1 indep, Golden et al 2004, N2 vs daf-2 different genes at , Golden et al 2004, N2 vs daf-2 age different gene, Golden et al 2004, N2 differentially expressed gen, Jones et al 2001 T3 20 most abundant Dauer, Lund et al 2002 Fig1 aging-regulated genes, Murphy et al 2003 Fig2 Class1 elongate lifespan, ViswanathanM et al 2005 S2 daf-16 Resveratrol, ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S8 SAGE genes in the dauer exit F36F2.2 F36F2.2 F36F2.2; 1J593; CE15976; WBGene00009476; WP:CE15976 Lund et al 2002 Fig4 Mount 15, Murphy et al 2003 Fig2 Class1 elongate lifespan, ViswanathanM et al 2005 S2 sir-2.1 regulated, ViswanathanM et al 2005 S2 daf-16 Resveratrol, Wang et al 2003 S3 genes pass one-way ANOVA, Wang et al 2003 S4 Dauer Enriched, Wang et al 2003 S4 genes pass two-wayANOVA P0 F38A1.5 F38A1.5 F38A1.5; 4C0; CE17805; WBGene00009518; WP:CE17805 phospholipase A2 receptor Murphy et al 2003 Fig2 Class1 elongate lifespan, ReichertK et al 2005 T3 xenobiotic downregulated, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, list of genes in cluster C, Reinke et al 2004, GO categories, Reinke et al 2004, herm soma enriched genes, ViswanathanM et al 2005 S2 daf-16 Resveratrol, ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S3 genes pass one-way ANOVA, Wang et al 2003 S4 Early genes, Wang et al 2003 S4 genes pass two-wayANOVA P0 F38B6.4 F38B6.4 F38B6.4; CE28304; WBGene00018174; WP:CE28304; XH297 GARS/AIRS/GART McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Murphy et al 2003 Fig2 Class1 elongate lifespan, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, list of genes in cluster C, Reinke et al 2004, herm soma enriched genes, ViswanathanM et al 2005 S2 daf-16 Resveratrol F38E11.1 F38E11.1 hsp-12.3; F38E11.1; 4K208; CE03293; NM_069266; WBGene00002012; WP:CE03293 alpha-B-crystallin Lund et al 2002 Fig4 Mount 15, Murphy et al 2003 Fig2 Class1 elongate lifespan, ViswanathanM et al 2005 S2 sir-2.1 regulated F38E11.2 F38E11.2 hsp-12.6; hsp-20; F38E11.2; 4K210; CE03294; NM_069267; WBGene00002013; WBGene00002022; WP:CE03294 alpha-B-crystallin Jones et al 2001 Dauer specific genes P<0.05, Jones et al 2001 T3 20 most abundant Dauer, Kwon et al 2004 T1 transient-induction Ethanol-res, Murphy et al 2003 Fig2 Class1 elongate lifespan, Wang et al 2003 S3 genes pass one-way ANOVA, Wang et al 2003 S8 SAGE genes in the dauer exit, Wang et al 2003 S7 SAGE genes in the dataset, Wang et al 2003 S4 genes pass two-wayANOVA P0, Wang et al 2003 S4 Dauer Enriched F40D4.3 F40D4.3 srh-159; F40D4.3; 5R657; CE19837; NM_074949; WBGene00005375; WP:CE19837 Murphy et al 2003 Fig2 Class1 elongate lifespan F40F12.1 F40F12.1 sdz-17; F40F12.1; 3L6; CE00616; WBGene00009590; WP:CE00616 Transthyretin-like family Murphy et al 2003 Fig2 Class1 elongate lifespan, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, mixed sperm soma, Reinke et al 2004, GO categories, Reinke et al 2004, list of genes in cluster D, Reinke et al 2004, fem3 enriched genes, ViswanathanM et al 2005 S2 sir-2.1 regulated F41B5.4 F41B5.4 cyp-33C3; F41B5.4; CE10222; NM_071214; WBGene00018262; WP:CE10222 cytochrome P450 McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Murphy et al 2003 Fig2 Class1 elongate lifespan, Wang et al 2003 S3 genes pass one-way ANOVA, Wang et al 2003 S4 Dauer Enriched, Wang et al 2003 S4 genes pass two-wayANOVA P0 F42F12.6 F42F12.6 nspc-13; F42F12.6; CE31939; WBGene00009637; WP:CE31939; XM975 Murphy et al 2003 Fig2 Class1 elongate lifespan, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, herm soma enriched genes, ViswanathanM et al 2005 S2 sir-2.1 regulated F42F12.7 F42F12.7 nspc-14; F42F12.7; WBGene00009638; XM976 Murphy et al 2003 Fig2 Class1 elongate lifespan F43H9.4 F43H9.4 F43H9.4; 5I507; CE27381; WBGene00018400; WP:CE27381 Kwon et al 2004 T1 late-induction Ethanol-response, Murphy et al 2003 Fig2 Class1 elongate lifespan, ViswanathanM et al 2005 S2 sir-2.1 regulated F45D3.4 F45D3.4 F45D3.4; 5N32; CE10474; CE38518; WBGene00009724; WP:CE10474; WP:CE38518 Murphy et al 2003 Fig2 Class1 elongate lifespan, Romagnolo et al 2002 Fig3b Unkown, Romagnolo et al 2002 Fig5 genes in let-60 timecour, Shen et al 2005 T1 hif-1indepen hypoxia, ViswanathanM et al 2005 S2 sir-2.1 regulated F45E6.5 F45E6.5 F45E6.5; WBGene00043329 Murphy et al 2003 Fig2 Class1 elongate lifespan F46C5.1 F46C5.1 F46C5.1; 2J110; CE03343; WBGene00009778; WP:CE03343 Murphy et al 2003 Fig2 Class1 elongate lifespan F46H5.7 F46H5.7 F46H5.7; F46H5.7a.1; F46H5.7a.2; F46H5.7c.1; F46H5.7c.2; CE04593; CE31170; CE34026; WBGene00018522; WP:CE04593; WP:CE31170; WP:CE34026; XH858 Murphy et al 2003 Fig2 Class1 elongate lifespan, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, list of genes in cluster B, ViswanathanM et al 2005 S2 sir-2.1 regulated F47B8.4 F47B8.4 F47B8.4; 5O804; CE10638; WBGene00009805; WP:CE10638 Murphy et al 2003 Fig2 Class1 elongate lifespan, Romagnolo et al 2002 Fig3b Unkown, ViswanathanM et al 2005 S2 sir-2.1 regulated F47C12.3 F47C12.3 srh-223; F47C12.3; 4E745; CE17836; NM_068052; WBGene00005433; WP:CE17836 7TM chemoreceptor, srh family Murphy et al 2003 Fig2 Class1 elongate lifespan, Romagnolo et al 2002 Fig3b Unkown, ViswanathanM et al 2005 S2 sir-2.1 regulated F47H4.10 F47H4.10 skr-5; F47H4.10; 5R829; CE20827; NM_074992; WBGene00004811; WP:CE20827 The skr-5 gene encodes a homolog of Skp1 in S. cerevisiae that has no known function in vivo, since skr-5(RNAi) animals are at least superficially normal. Lund et al 2002 Fig4 Mount 15, Murphy et al 2003 Fig2 Class1 elongate lifespan, Romagnolo et al 2002 Fig3b Unkown, ViswanathanM et al 2005 S2 daf-16 Resveratrol F48D6.4 F48D6.4 F48D6.4; CE07261; CE28400; CE29328; WBGene00018602; WP:CE07261; WP:CE28400; WP:CE29328; XE866 Murphy et al 2003 Fig2 Class1 elongate lifespan, ViswanathanM et al 2005 S2 sir-2.1 regulated F49A5.6 F49A5.6 thn-4; F49A5.6; 5R346; CE16069; NM_074862; WBGene00009858; WP:CE16069 Thaumatin family Golden et al 2004, N2 differentially expressed gen, Golden et al 2004, N2 vs daf-2 different genes at , Golden et al 2004, N2 vs daf-2 age different gene, Murphy et al 2003 Fig2 Class1 elongate lifespan F49E11.9 F49E11.9 scl-1; F49E11.9; 4N819; CE05905; NM_070101; WBGene00004742; WP:CE05905 testis-specific protein TPX-1 like McElwee et al 2003 T1 targets of daf-16, Murphy et al 2003 Fig2 Class1 elongate lifespan, ViswanathanM et al 2005 S2 sir-2.1 regulated F52A8.2 F52A8.2 eat-11; gpb-2; F52A8.2; 1H896; CE17845; NM_059671; WBGene00001680; WP:CE17845 gpb-2 encodes an ortholog of Gbeta(5), that is dispensable for viability, but required for normal egg-laying, locomotion, and pharyngeal pumping; GBP-2 may regulate the interaction between the GOA-1 and EGL-30 signaling pathways based on genetic analysis; gpb-2 is expressed throughout development in the nervous system and in muscle, and expression is dependent upon expression of both EAT-16 and EGL-10. guanine nucleotide-binding protein McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Murphy et al 2003 Fig2 Class1 elongate lifespan F52E4.5 F52E4.5 F52E4.5; CE07272; WBGene00018702; WP:CE07272; XD704 Murphy et al 2003 Fig2 Class1 elongate lifespan, Reinke et al 2004, list of genes in cluster A, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, wt herm vs wt herm enriched gen, Reinke et al 2004, IVb male soma enriched genes, ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S3 genes pass one-way ANOVA, Wang et al 2003 S4 genes pass two-wayANOVA P0, Wang et al 2003 S4 LateList F52H3.5 F52H3.5 F52H3.5; 2K321; CE03401; WBGene00009947; WP:CE03401 Jones et al 2001 Non dauer genes P<0.05, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Murphy et al 2003 Fig2 Class1 elongate lifespan, ViswanathanM et al 2005 S2 sir-2.1 regulated, ViswanathanM et al 2005 S2 daf-16 Resveratrol F52H3.7 F52H3.7 lec-2; F52H3.7; F52H3.7b.1; F52H3.7b.2; F52H3.7b.3; 2K300; CE29330; CE32894; NM_063764; WBGene00002265; WP:CE29330; WP:CE32894 lec-2 encodes a 'tandem repeat' type galectin (beta-galactosyl-binding lectin) containing two, tandemly arranged carbohydrate recognition domains; by homology, LEC-2 may play roles in cell adhesion and aggregation, proliferation, or programmed cell death, but as loss of lec-2 activity via large-scale RNAi screens does not result in obvious abnormalities, the precise role of LEC-2 in C. elegans development and/or behavior is not yet known. galactoside-binding lectin Murphy et al 2003 Fig2 Class1 elongate lifespan, ViswanathanM et al 2005 S2 sir-2.1 regulated F53A9.1 F53A9.1 F53A9.1; CE02760; WBGene00018724; WP:CE02760; XJ331 Murphy et al 2003 Fig2 Class1 elongate lifespan, Reinke et al 2004, list of genes in cluster A, Reinke et al 2004, list of genes in cluster order, ViswanathanM et al 2005 S2 sir-2.1 regulated F53C3.12 F53C3.12 F53C3.12; 2E200; CE32672; WBGene00018755; WP:CE32672 McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Murphy et al 2003 Fig2 Class1 elongate lifespan, ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S3 genes pass one-way ANOVA, Wang et al 2003 S4 Dauer Enriched, Wang et al 2003 S4 genes pass two-wayANOVA P0 F53C3.5 F53C3.5 F53C3.5; 2E191; CE35940; WBGene00018749; WP:CE35940 Lund et al 2002 Fig1 aging-regulated genes, Murphy et al 2003 Fig2 Class1 elongate lifespan F53F4.13 F53F4.13 F53F4.13; 5O92; CE10978; WBGene00009995; WP:CE10978 Murphy et al 2003 Fig2 Class1 elongate lifespan, Reinke et al 2004, list of genes in cluster A, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, wt herm vs wt herm enriched gen, ViswanathanM et al 2005 S2 sir-2.1 regulated F53G12.6 F53G12.6 spe-8; F53G12.6; 1A593; CE29331; NM_058279; WBGene00004962; WP:CE29331 protein-tyrosine kinase Murphy et al 2003 Fig2 Class1 elongate lifespan, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, wt males vs glp4 male enriched , Reinke et al 2004, spermatogenesis enriched genes, Reinke et al 2004, wt herm vs wt herm enriched gen, Reinke et al 2004, fem3 enriched genes, Reinke et al 2004, shared sperm F54D5.3 F54D5.3 F54D5.3; F54D5.3.1; F54D5.3.2; 2L863; CE28033; WBGene00010049; WP:CE28033 Murphy et al 2003 Fig2 Class1 elongate lifespan, ViswanathanM et al 2005 S2 sir-2.1 regulated F54F7.3 F54F7.3 F54F7.3; CE03418; WBGene00010065; WP:CE03418; XM468 Murphy et al 2003 Fig2 Class1 elongate lifespan, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, herm soma enriched genes, ViswanathanM et al 2005 S2 sir-2.1 regulated, ViswanathanM et al 2005 S2 daf-16 Resveratrol F56D5.7 F56D5.7 F56D5.7; WBGene00010151 Murphy et al 2003 Fig2 Class1 elongate lifespan, Reinke et al 2004, list of genes in cluster A, Reinke et al 2004, list of genes in cluster order, ViswanathanM et al 2005 S2 sir-2.1 regulated F57B1.7 F57B1.7 F57B1.7; 5N702; CE11298; WBGene00010190; WP:CE11298 Murphy et al 2003 Fig2 Class1 elongate lifespan, ViswanathanM et al 2005 S2 sir-2.1 regulated, ViswanathanM et al 2005 S2 daf-16 Resveratrol, Wang et al 2003 S3 genes pass one-way ANOVA, Wang et al 2003 S4 Dauer Enriched, Wang et al 2003 S4 genes pass two-wayANOVA P0 F57H12.7 F57H12.7 mec-17; F57H12.7; 4I750; CE17128; NM_068936; WBGene00003178; WP:CE17128 mec-17 encodes a protein that has no clearly recognizable motifs yet shares a domain of similarity with an additional C. elegans protein as well as proteins from Drosophila, mouse, and human; MEC-17 activity is required for maintaining the differentiated state of the touch receptors, and hence the animal's touch sensitivity, during later stages of larval development; mec-17 is expressed solely in the touch receptor cells from late embryogenesis through adulthood, and this expression is dependent upon the MEC-3 LIM homeodomain transcription factor; in turn, as MEC-17 is necessary for maintaining differentiated touch receptors, its activity is required for continued expression of MEC-3 and the MEC-7 beta-tubulin. McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Murphy et al 2003 Fig2 Class1 elongate lifespan, Zhang et al 2002, T1 mec-3 dependent genes F59F4.4 F59F4.4 acl-1; F59F4.4; CE11552; NM_078205; WBGene00010339; WP:CE11552; XQ469 1-acyl-SN-glycerol-3-phosphate acyltransferase Jones et al 2001 Non dauer genes P<0.05, Murphy et al 2003 Fig2 Class1 elongate lifespan, Reinke et al 2004, fem3 enriched genes, Reinke et al 2004, mixed sperm soma, Reinke et al 2004, GO categories, ViswanathanM et al 2005 S2 daf-16 Resveratrol, ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S3 genes pass one-way ANOVA, Wang et al 2003 S4 genes pass two-wayANOVA P0, Wang et al 2003 S4 Dauer Enriched H10D18.2 H10D18.2 H10D18.2; 5E293; CE23800; WBGene00019178; WP:CE23800 Jones et al 2001 Dauer specific genes P<0.05, Murphy et al 2003 Fig2 Class1 elongate lifespan, Reinke et al 2004, wt herm vs wt herm enriched gen, Reinke et al 2004, IVb male soma enriched genes, ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S3 genes pass one-way ANOVA, Wang et al 2003 S8 SAGE genes in the dauer exit, Wang et al 2003 S7 SAGE genes in the dataset, Wang et al 2003 S4 genes pass two-wayANOVA P0, Wang et al 2003 S4 Dauer Enriched H10D18.3 H10D18.3 srw-6; H10D18.3; 5E291; CE23801; NM_071653; WBGene00005753; WP:CE23801 7TM chemoreceptor, srw family Jones et al 2001 Dauer specific genes P<0.05, Murphy et al 2003 Fig2 Class1 elongate lifespan, Wang et al 2003 S8 SAGE genes in the dauer exit H12D21.1 H12D21.1 nspa-1; H12D21.1; 5P366; CE15223; NM_074268; WBGene00010377; WP:CE15223 McElwee et al 2003 T1 targets of daf-16, Murphy et al 2003 Fig2 Class1 elongate lifespan, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, spermatogenesis enriched genes, Reinke et al 2004, fem3 enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, wt males vs glp4 male enriched , Reinke et al 2004, list of genes in cluster D, Reinke et al 2004, shared sperm, ViswanathanM et al 2005 S2 daf-16 Resveratrol, ViswanathanM et al 2005 S2 sir-2.1 regulated H14N18.1 H14N18.1 unc-23; vab-4; H14N18.1; H14N18.1b.1; H14N18.1b.2; 5J419; CE17973; CE33124; CE37777; NM_072906; NM_182342; WBGene00006760; WP:CE17973; WP:CE33124; WP:CE37777 GuhaThakurta et al 2002 T1 upregu on heat stress, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Murphy et al 2003 Fig2 Class1 elongate lifespan, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, list of genes in cluster C, Roy et al 2002 S3 muscle genes, ViswanathanM et al 2005 S2 sir-2.1 regulated H16D19.1 H16D19.1 clec-13; H16D19.1; 1N227; CE13381; WBGene00010399; WP:CE13381 Lectin C-type domain short and long forms (2 domains), CUB domain Murphy et al 2003 Fig2 Class1 elongate lifespan H22K11.1 H22K11.1 asp-3; H22K11.1; CE19495; NM_076741; WBGene00000216; WP:CE19495; XH411 asp-3 encodes an aspartyl protease homolog that is required, in parallel with ASP-4 but downstream of CLP-1 and TRA-3, for degenerative (necrotic-like) cell death in neurons induced by mutations such as mec-4(d), deg-3(d), or gsa-1(gf). aspartyl protease Golden et al 2004, N2 differentially expressed gen, Murphy et al 2003 Fig2 Class1 elongate lifespan, ViswanathanM et al 2005 S2 sir-2.1 regulated JC8.8 JC8.8 JC8.8; JC8.8.1; JC8.8.2; 4O16; CE33800; WBGene00010440; WP:CE33800 Transthyretin-like family Murphy et al 2003 Fig2 Class1 elongate lifespan, Reinke et al 2004, list of genes in cluster A, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, fem3 enriched genes, Reinke et al 2004, mixed sperm soma, Reinke et al 2004, GO categories, ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S3 genes pass one-way ANOVA, Wang et al 2003 S4 genes pass two-wayANOVA P0, Wang et al 2003 S4 Dauer Enriched K01A2.2 K01A2.2 far-7; K01A2.2; K01A2.2a.1; K01A2.2a.2; 2A611; CE19511; CE33412; NM_061307; NM_182191; WBGene00001391; WP:CE19511; WP:CE33412 Murphy et al 2003 Fig2 Class1 elongate lifespan, Romagnolo et al 2002 Fig3b Unkown, Romagnolo et al 2002 Fig5 genes in let-60 timecour, ViswanathanM et al 2005 S2 daf-16 Resveratrol K01A6.2 K01A6.2 magi-1; K01A6.2; 4M493; CE37387; WBGene00010444; WP:CE37387 membrane-associated guanylate kinase homolog (MAGUK) Murphy et al 2003 Fig2 Class1 elongate lifespan, ViswanathanM et al 2005 S2 daf-16 Resveratrol K02E11.5 K02E11.5 K02E11.5; 5O733; CE11652; WBGene00010514; WP:CE11652 Murphy et al 2003 Fig2 Class1 elongate lifespan, ViswanathanM et al 2005 S2 sir-2.1 regulated K03C7.2 K03C7.2 fkh-9; K03C7.2; K03C7.2b.1; K03C7.2b.2; K03C7.2c.1; K03C7.2c.2; K03C7.2c.3; CE31196; CE34332; CE39581; WBGene00001441; WP:CE31196; WP:CE34332; WP:CE39581; XE436 fkh-9 encodes a member of the forkhead domain transcription factor family. Murphy et al 2003 Fig2 Class1 elongate lifespan, ViswanathanM et al 2005 S2 sir-2.1 regulated K04A8.5 K04A8.5 K04A8.5; 5H31; CE11708; WBGene00019376; WP:CE11708 lipase Jones et al 2001 Dauer specific genes P<0.05, Murphy et al 2003 Fig2 Class1 elongate lifespan, ViswanathanM et al 2005 S2 daf-16 Resveratrol, Wang et al 2003 S3 genes pass one-way ANOVA, Wang et al 2003 S8 SAGE genes in the dauer exit, Wang et al 2003 S7 SAGE genes in the dataset, Wang et al 2003 S4 genes pass two-wayANOVA P0, Wang et al 2003 S4 Dauer Enriched K07A1.7 K07A1.7 K07A1.7; 1K172; CE11852; WBGene00010614; WP:CE11852 McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Murphy et al 2003 Fig2 Class1 elongate lifespan, Wang et al 2003 S3 genes pass one-way ANOVA, Wang et al 2003 S4 Dauer Enriched, Wang et al 2003 S4 genes pass two-wayANOVA P0 K07B1.4 K07B1.4 K07B1.4; K07B1.4b.1; K07B1.4b.2; 5J811; CE11882; CE27391; WBGene00019464; WP:CE11882; WP:CE27391 McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, McElwee et al 2003 T1 targets of daf-16, Murphy et al 2003 Fig2 Class1 elongate lifespan, Reinke et al 2004, wt herm vs wt male enriched gen, ViswanathanM et al 2005 S2 sir-2.1 regulated K07C6.3 K07C6.3 cyp-35B2; K07C6.3; 5E421; CE17174; NM_071693; WBGene00019471; WP:CE17174 cytochrome P450 Custodia et al 2001 T2 Cytochrome P450, Murphy et al 2003 Fig2 Class1 elongate lifespan, ReichertK et al 2005 T1 xenobiotic induced P450, ViswanathanM et al 2005 S2 sir-2.1 regulated, ViswanathanM et al 2005 S2 daf-16 Resveratrol K07C6.4 K07C6.4 ccp-35B1; cyp-35B1; dod-13; K07C6.4; 5E419; CE17175; NM_071692; WBGene00019472; WP:CE17175 cytochrome P450 Murphy et al 2003 Fig2 Class1 elongate lifespan, ReichertK et al 2005 T1 xenobiotic induced P450, Wang et al 2003 S6 removed genes of contamination K07E3.3 K07E3.3 dao-3; K07E3.3; CE25047; NM_076961; WBGene00000929; WP:CE25047; XI704 dao-3 encodes a protein containing a tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain; expression is regulated by DAF-2. methylenetetrahydrofolate dehydrogenase Murphy et al 2003 Fig2 Class1 elongate lifespan, ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S6 removed genes of contamination K07E3.8 K07E3.8 vem-1; K07E3.8; CE21027; CE34578; WBGene00006890; WP:CE21027; WP:CE34578; XI706 McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Murphy et al 2003 Fig2 Class1 elongate lifespan, ReichertK et al 2005 T1 xenobiotic induced P450, ViswanathanM et al 2005 S2 sir-2.1 regulated K08B4.6 K08B4.6 cli-2; cpi-1; K08B4.6; 4G858; CE18035; NM_068514; WBGene00000535; WP:CE18035 cli-2 encodes a homolog of cysteine protease inhibitors (cystatins); cli-2 is at least superficially dispensable for viability and gross morphology. protease inhibitor Murphy et al 2003 Fig2 Class1 elongate lifespan, Reinke et al 2004, list of genes in cluster A, Reinke et al 2004, list of genes in cluster order, ViswanathanM et al 2005 S2 sir-2.1 regulated, ViswanathanM et al 2005 S2 daf-16 Resveratrol K08F4.7 K08F4.7 gst-4; K08F4.7; 4K907; CE06155; CeGST1; NM_069447; WBGene00001752; WP:CE06155 gst-4 encodes a predicted glutathione S-transferase; mRNA is expressed in adults and accumulation increases in response to paraquat. glutathione S-transferase Murphy et al 2003 Fig2 Class1 elongate lifespan, ReichertK et al 2005 T3 xenobiotic downregulated, ReichertK et al 2005 T1 xenobiotic induced GSTs, Reinke et al 2004, wt herm vs wt herm enriched gen, ViswanathanM et al 2005 S2 sir-2.1 regulated K09C4.5 K09C4.5 K09C4.5; CE37126; WBGene00019550; WP:CE37126; XD905 sugar transporter Murphy et al 2003 Fig2 Class1 elongate lifespan, ViswanathanM et al 2005 S2 sir-2.1 regulated K10B3.8 K10B3.8 gpd-2; K10B3.8; CE07371; NM_076134; WBGene00001684; WP:CE07371; XD732 gpd-2 encodes one of four C. elegans glyceraldehyde-3-phosphate dehydrogenases (GAPDHs); by homology, GPD-2 is predicted to reversibly catalyze the oxidation and phosphorylation of glyceraldehyde-3-phosphate to 1,3-diphosphoglycerate during glycolysis; in C. elegans, GPD-2 and GPD-3 constitute the major GAPDH isoenzymes and are expressed at highest levels during postembryonic development, primarily in the actin-containing A and I zones of body-wall muscle; loss of gpd-2 function via RNA-mediated interference (RNAi) does not result in any abnormalities. McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Murphy et al 2003 Fig2 Class1 elongate lifespan, Roy et al 2002 S3 muscle genes, ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S3 genes pass one-way ANOVA, Wang et al 2003 S4 LateList, Wang et al 2003 S4 genes pass two-wayANOVA P0 K11D2.2 K11D2.2 asah-1; dod-7; K11D2.2; 1N99; CE12120; NM_060772; WBGene00010769; WP:CE12120 K11D2.2 is orthologous to the human gene N-ACYLSPHINGOSINE AMIDOHYDROLASE (ASAH; OMIM:228000), which when mutated leads to Farber lipogranulomatosis. Human PHP32 protein like Murphy et al 2003 Fig2 Class1 elongate lifespan K11G9.6 K11G9.6 met-I; mtl-1; K11G9.6; 5H172; CE07379; NM_072295; WBGene00003473; WP:CE07379 mtl-1 encodes a metallothionein, a small, cysteine-rich, metal-binding protein; MTL-1 functions in metal detoxification and homeostasis and in stress adaptation; MTL-1 expression is induced in larval and adult intestinal cells following exposure to cadmium or heat stress, and in addition, is detected constitutively in three cells in the posterior pharyngeal bulb; MTL-1 intestinal expression is dependent upon ELT-2, an intestine-specific GATA-type transcription factor. Lund et al 2002 Fig4 Mount 15, Murphy et al 2003 Fig2 Class1 elongate lifespan, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, mixed oogenesis soma, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, herm soma enriched genes, ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S3 genes pass one-way ANOVA, Wang et al 2003 S4 genes pass two-wayANOVA P0, Wang et al 2003 S4 Dauer Enriched K12G11.3 K12G11.3 dod-11; sodh-1; K12G11.3; K12G11.3.1; K12G11.3.2; K12G11.3.3; 5M369; CE12212; NM_073590; WBGene00010790; WP:CE12212 alcohol dehydrogenase McCarroll et al 2004 SFig5 conserved w/ yeast, Murphy et al 2003 Fig2 Class1 elongate lifespan, ViswanathanM et al 2005 S2 sir-2.1 regulated K12G11.4 K12G11.4 dod-14; sodh-2; K12G11.4; 5M370; CE12214; NM_073591; WBGene00010791; WP:CE12214 alcohol dehydrogenase Murphy et al 2003 Fig2 Class1 elongate lifespan M01H9.3 M01H9.3 M01H9.3; M01H9.3a.1; M01H9.3a.2; 4F234; CE28614; CE28615; CE37722; WBGene00019719; WP:CE28614; WP:CE28615; WP:CE37722 Murphy et al 2003 Fig2 Class1 elongate lifespan, Shen et al 2005 T1 hif-1 depend hypoxia, ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S3 genes pass one-way ANOVA, Wang et al 2003 S4 Dauer Enriched, Wang et al 2003 S4 genes pass two-wayANOVA P0 M02D8.4 M02D8.4 M02D8.4; M02D8.4b.1; M02D8.4b.2; M02D8.4b.3; CE04760; CE31201; CE37263; WBGene00019730; WP:CE04760; WP:CE31201; WP:CE37263; XJ368 asparagine synthase McCarroll et al 2004 SFig5 conserved w/ yeast, Murphy et al 2003 Fig2 Class1 elongate lifespan, Reinke et al 2004, list of genes in cluster A, Reinke et al 2004, list of genes in cluster order, ViswanathanM et al 2005 S2 sir-2.1 regulated M04G12.2 M04G12.2 cpz-2; M04G12.2; 5N863; CE12424; NM_073917; WBGene00000789; WP:CE12424 cysteine protease Murphy et al 2003 Fig2 Class1 elongate lifespan, Reinke et al 2004, list of genes in cluster A, Reinke et al 2004, list of genes in cluster order, ViswanathanM et al 2005 S2 sir-2.1 regulated M60.3 M60.3 M60.3; WBGene00043452 Murphy et al 2003 Fig2 Class1 elongate lifespan, ViswanathanM et al 2005 S2 sir-2.1 regulated M7.9 M7.9 M7.9; 4L864; CE12220; WBGene00010885; WP:CE12220 Murphy et al 2003 Fig2 Class1 elongate lifespan, Reinke et al 2004, wt herm vs wt herm enriched gen, Reinke et al 2004, IVb male soma enriched genes, ViswanathanM et al 2005 S2 sir-2.1 regulated PDB1.1 PDB1.1 PDB1.1; CE31209; CE39603; CE39604; NM_076878; WBGene00019803; WP:CE31209; WP:CE39603; WP:CE39604; XI176 Murphy et al 2003 Fig2 Class1 elongate lifespan, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, herm soma enriched genes, Reinke et al 2004, list of genes in cluster B, ViswanathanM et al 2005 S2 sir-2.1 regulated R03E9.1 R03E9.1 mdl-1; R03E9.1; CE04784; NM_076735; WBGene00003163; WP:CE04784; XH361 human Max-interacting bHLH-Zip protein Murphy et al 2003 Fig2 Class1 elongate lifespan, ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S3 genes pass one-way ANOVA, Wang et al 2003 S4 Dauer Enriched, Wang et al 2003 S4 genes pass two-wayANOVA P0 R05F9.13 R05F9.13 msp-31; R05F9.13; 2F208; NM_062497; WBGene00003429 msp-31 encodes a member of the major sperm protein family; msp-31 has a C. briggsae homolog as predicted by the Wobble Aware Bulk Aligner (WABA); expression is enriched in sperm. major sperm protein Murphy et al 2003 Fig2 Class1 elongate lifespan, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, spermatogenesis enriched genes, Reinke et al 2004, wt herm vs wt herm enriched gen, Reinke et al 2004, fem3 enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, wt males vs glp4 male enriched , Reinke et al 2004, list of genes in cluster D, Reinke et al 2004, shared sperm R09B5.6 R09B5.6 hacd-1; R09B5.6; R09B5.6.1; R09B5.6.2; 5B939; CE12628; WBGene00019978; WP:CE12628 3-hydroxyacyl-CoA dehydrogenase Murphy et al 2003 Fig2 Class1 elongate lifespan, ReichertK et al 2005 T3 xenobiotic downregulated, ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S3 genes pass one-way ANOVA, Wang et al 2003 S4 Dauer Enriched, Wang et al 2003 S4 genes pass two-wayANOVA P0 R11A5.4 R11A5.4 R11A5.4; R11A5.4c.1; R11A5.4c.2; R11A5.4c.3; R11A5.4d.1; R11A5.4d.2; R11A5.4d.3; R11A5.4d.4; R11A5.4d.5; 1I447; CE12728; CE36358; CE36359; CE36360; WBGene00011232; WP:CE12728; WP:CE36358; WP:CE36359; WP:CE36360 phosphoenolpyruvate carboxykinase McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Murphy et al 2003 Fig2 Class1 elongate lifespan, ViswanathanM et al 2005 S2 sir-2.1 regulated R12A1.4 R12A1.4 ges-1; R12A1.4; R12A1.4.1; R12A1.4.2; 5B906; CE28763; NM_071010; WBGene00001578; WP:CE28763; ges1 ges-1 encodes a gut-specific type B carboxylesterase; by homology, GES-1 hydrolyzes carboxylic ester substrates to yield an alcohol and a carboxylic anion, however, loss of GES-1 activity via mutation or RNAi does not result in any obvious abnormalities; GES-1 is expressed solely in the intestinal, or E, lineage from the 4 E-cell stage of gut development through adulthood; GES-1 contains a C-terminal endoplasmic reticulum (ER) retention sequence, KDEL, which suggests that it localizes to the ER lumen; GES-1 expression in the gut appears to be positively regulated by ELT-2, a gut-specific GATA-type transcription factor expressed throughout the C. elegans life cycle and essential for normal gut development. carboxylesterase Murphy et al 2003 Fig2 Class1 elongate lifespan, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, list of genes in cluster C, Reinke et al 2004, herm soma enriched genes, ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S3 genes pass one-way ANOVA, Wang et al 2003 S4 LateList, Wang et al 2003 S4 genes pass two-wayANOVA P0 R12B2.5 R12B2.5 mdt-15; R12B2.5; R12B2.5b.1; R12B2.5b.2; 3G918; CE25078; CE30108; NM_171134; NM_171867; WBGene00007016; WP:CE25078; WP:CE30108 Murphy et al 2003 Fig2 Class1 elongate lifespan, ViswanathanM et al 2005 S2 sir-2.1 regulated R13F6.2 R13F6.2 R13F6.2; 3H949; CE25085; WBGene00020065; WP:CE25085 Murphy et al 2003 Fig2 Class1 elongate lifespan, Reinke et al 2004, wt herm vs wt herm enriched gen, Reinke et al 2004, IVb male soma enriched genes R13H4.5 R13H4.5 R13H4.5; R13H4.5.1; R13H4.5.2; 5M341; CE12808; WBGene00011263; WP:CE12808 This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins. Jones et al 2001 Dauer specific genes P<0.05, Murphy et al 2003 Fig2 Class1 elongate lifespan, Reinke et al 2004, list of genes in cluster A, Reinke et al 2004, list of genes in cluster order, ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S7 SAGE genes in the dataset, Wang et al 2003 S8 SAGE genes in the dauer exit T01B11.2 T01B11.2 T01B11.2; 4J214; CE12894; CE33686; WBGene00020139; WP:CE12894; WP:CE33686 aminotransferase McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Murphy et al 2003 Fig2 Class1 elongate lifespan, Reinke et al 2004, fem3 enriched genes, Reinke et al 2004, mixed sperm soma, Reinke et al 2004, GO categories, ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S3 genes pass one-way ANOVA, Wang et al 2003 S4 Early genes, Wang et al 2003 S4 genes pass two-wayANOVA P0 T02B5.1 T02B5.1 T02B5.1; 5O644; CE27775; WBGene00011362; WP:CE27775 carboxylesterase Murphy et al 2003 Fig2 Class1 elongate lifespan, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, herm soma enriched genes, ViswanathanM et al 2005 S2 sir-2.1 regulated, ViswanathanM et al 2005 S2 daf-16 Resveratrol, ViswanathanM et al 2005 S2 Resveratrol regulate WT T04H1.2 T04H1.2 T04H1.2; T04H1.2.1; T04H1.2.2; 5M722; CE13169; WBGene00011449; WP:CE13169 GTP-binding protein McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Murphy et al 2003 Fig2 Class1 elongate lifespan, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, list of genes in cluster E, ViswanathanM et al 2005 S2 sir-2.1 regulated T06E6.5 T06E6.5 fbxa-135; T06E6.5; 5P883; CE39277; WBGene00011539; WP:CE39277 This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins; this gene's encoded protein also contains an FTH/DUF38 motif, which may also mediate protein-protein interaction. Murphy et al 2003 Fig2 Class1 elongate lifespan, Romagnolo et al 2002 Fig3b Unkown, ViswanathanM et al 2005 S2 daf-16 Resveratrol T07D10.4 T07D10.4 clec-15; T07D10.4; 1N224; WBGene00011584 C-type lectin Murphy et al 2003 Fig2 Class1 elongate lifespan, ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S6 removed genes of contamination T07H3.3 T07H3.3 math-38; T07H3.3; 2B864; CE19564; CE36015; WBGene00020326; WP:CE19564; WP:CE36015 Murphy et al 2003 Fig2 Class1 elongate lifespan, ViswanathanM et al 2005 S2 sir-2.1 regulated T10B9.1 T10B9.1 ccp-13A4; cyp-13A4; dod-1; T10B9.1; 2K84; CE01654; NM_063710; WBGene00011671; WP:CE01654 cytochrome P450 McCarroll et al 2004 SFig5 conserved w/ yeast, Menzel et al 2001 T3 CYP genes, Murphy et al 2003 Fig2 Class1 elongate lifespan, ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S4 TransientList, Wang et al 2003 S3 genes pass one-way ANOVA, Wang et al 2003 S4 genes pass two-wayANOVA P0 T10H4.11 T10H4.11 cyp-34A2; T10H4.11; 5P764; CE16396; NM_074387; WBGene00011699; WP:CE16396 cytochrome P450 Jones et al 2001 Dauer specific genes P<0.05, Murphy et al 2003 Fig2 Class1 elongate lifespan, Wang et al 2003 S7 SAGE genes in the dataset, Wang et al 2003 S3 genes pass one-way ANOVA, Wang et al 2003 S4 Dauer Enriched, Wang et al 2003 S8 SAGE genes in the dauer exit, Wang et al 2003 S4 genes pass two-wayANOVA P0 T13B5.3 T13B5.3 T13B5.3; 2B388; CE13607; WBGene00020471; WP:CE13607 acid phosphatase Jones et al 2001 Non dauer genes P<0.05, Murphy et al 2003 Fig2 Class1 elongate lifespan, Reinke et al 2004, herm soma enriched genes, Reinke et al 2004, GO categories, ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S3 genes pass one-way ANOVA, Wang et al 2003 S4 Climbing, Wang et al 2003 S4 genes pass two-wayANOVA P0 T17H7.1 T17H7.1 T17H7.1; 3B359; CE07502; WBGene00020550; WP:CE07502 Murphy et al 2003 Fig2 Class1 elongate lifespan, ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S3 genes pass one-way ANOVA, Wang et al 2003 S4 LateList, Wang et al 2003 S4 genes pass two-wayANOVA P0 T19B10.2 T19B10.2 phi-59; T19B10.2; T19B10.2.1; T19B10.2.2; 5L703; CE16413; WBGene00011831; WP:CE16413 Murphy et al 2003 Fig2 Class1 elongate lifespan, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, list of genes in cluster B, ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S3 genes pass one-way ANOVA, Wang et al 2003 S4 LateList, Wang et al 2003 S4 genes pass two-wayANOVA P0 T20G5.7 T20G5.7 dod-6; T20G5.7; 3L287; CE00587; NM_066856; WBGene00011869; WP:CE00587 Murphy et al 2003 Fig2 Class1 elongate lifespan, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, list of genes in cluster B, ViswanathanM et al 2005 S2 daf-16 Resveratrol T20G5.8 T20G5.8 T20G5.8; 3L289; CE00588; WBGene00011870; WP:CE00588 Murphy et al 2003 Fig2 Class1 elongate lifespan, ViswanathanM et al 2005 S2 sir-2.1 regulated T21C9.8 T21C9.8 T21C9.8; 5L68; CE06477; WBGene00011894; WP:CE06477 Transthyretin-like family Lund et al 2002 Fig4 Mount 15, Murphy et al 2003 Fig2 Class1 elongate lifespan, ViswanathanM et al 2005 S2 daf-16 Resveratrol T22F3.11 T22F3.11 T22F3.11; 5E92; CE18279; CE33325; WBGene00020700; WP:CE18279; WP:CE33325 Murphy et al 2003 Fig2 Class1 elongate lifespan T22G5.7 T22G5.7 dod-5; spp-12; T22G5.7; 5O369; CE13994; NM_074042; WBGene00004997; WP:CE13994 Murphy et al 2003 Fig2 Class1 elongate lifespan, ViswanathanM et al 2005 S2 sir-2.1 regulated T23B3.2 T23B3.2 T23B3.2; 1H293; CE14010; WBGene00020710; WP:CE14010 Lund et al 2002 Fig4 Mount 15, Murphy et al 2003 Fig2 Class1 elongate lifespan, ViswanathanM et al 2005 S2 daf-16 Resveratrol T23G7.3 T23G7.3 T23G7.3; 2J456; CE03704; WBGene00011966; WP:CE03704 McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Murphy et al 2003 Fig2 Class1 elongate lifespan, Reinke et al 2004, wt herm vs wt male enriched gen, ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S5 genes common to feeding ANOVA, Wang et al 2003 S3 genes pass one-way ANOVA T23H2.2 T23H2.2 snt-4; T23H2.2; 1H17; CE30456; NM_059452; WBGene00004924; WP:CE30456 C2 domain protein Murphy et al 2003 Fig2 Class1 elongate lifespan, Reinke et al 2004, list of genes in cluster A, Reinke et al 2004, list of genes in cluster order, ViswanathanM et al 2005 S2 daf-16 Resveratrol, ViswanathanM et al 2005 S2 Resveratrol regulate WT, Wang et al 2003 S5 genes common to feeding ANOVA, Wang et al 2003 S3 genes pass one-way ANOVA T24E12.5 T24E12.5 T24E12.5; 2E47; CE35625; WBGene00020774; WP:CE35625 Murphy et al 2003 Fig2 Class1 elongate lifespan, ViswanathanM et al 2005 S2 sir-2.1 regulated T24F1.5 T24F1.5 T24F1.5; 2L608; CE02365; WBGene00011997; WP:CE02365 Murphy et al 2003 Fig2 Class1 elongate lifespan T25C12.2 T25C12.2 spp-9; T25C12.2; CE38555; NM_077517; WBGene00004994; WP:CE38555; XM107 Murphy et al 2003 Fig2 Class1 elongate lifespan T26F2.1 T26F2.1 T26F2.1; 5O453; WBGene00012057 chitinase Murphy et al 2003 Fig2 Class1 elongate lifespan T27E4.8 T27E4.8 hsp-16.1; hsp-16; T27E4.8; 5J568; CE14249; NM_072953; WBGene00002015; WP:CE14249 hsp-16.1 encodes a 16-kD heat shock protein (HSP) that is a member of the hsp16/hsp20/alphaB-crystallin (HSP16) family of heat shock proteins, and that is identical to the protein encoded by hsp-16.11; an hsp-16.1 reporter fusion, expressed broadly but most strongly in muscle and hypodermis, is induced solely in response to heat shock or other environmental stresses; expression is detectable in somatic tissues in post-gastrulation embryos, all larval stages, and in adults; HSP-16.1 is likely to function as a passive ligand temporarily preventing unfolded proteins from aggregating. heat shock protein HSP16-1 Murphy et al 2003 Fig2 Class1 elongate lifespan, Romagnolo et al 2002 Fig2a heat shock, ViswanathanM et al 2005 S2 sir-2.1 regulated T28B8.2 T28B8.2 Ceinsulin-1; igf-1; ins-18; T28B8.2; 1I725; CE27217; NM_059830; WBGene00002101; WP:CE27217 The ins-18 gene encodes an insulin/IGF-like peptide that may act in a common pathway with daf-2 to regulate lifespan. insulin-like growth factor I like Jones et al 2001 T2 lifespan and Dauer, Murphy et al 2003 Fig2 Class1 elongate lifespan, Reinke et al 2004, wt herm vs wt herm enriched gen, Reinke et al 2004, IVb male soma enriched genes, Wang et al 2003 S3 genes pass one-way ANOVA, Wang et al 2003 S4 Dauer Enriched, Wang et al 2003 S4 genes pass two-wayANOVA P0 T28C6.8 T28C6.8 T28C6.8; 4J594; CE26012; WBGene00012122; WP:CE26012 Murphy et al 2003 Fig2 Class1 elongate lifespan, ViswanathanM et al 2005 S2 sir-2.1 regulated, ViswanathanM et al 2005 S2 daf-16 Resveratrol, Wang et al 2003 S3 genes pass one-way ANOVA, Wang et al 2003 S4 Dauer Enriched, Wang et al 2003 S4 genes pass two-wayANOVA P0 T28D9.3 T28D9.3 T28D9.3; 2G777; CE02068; CE37155; CE37156; WBGene00020895; WP:CE02068; WP:CE37155; WP:CE37156 Jones et al 2001 Non dauer genes P<0.05, Murphy et al 2003 Fig2 Class1 elongate lifespan, Reinke et al 2004, mixed sperm soma, Reinke et al 2004, fem3 enriched genes, ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S4 Early genes, Wang et al 2003 S3 genes pass one-way ANOVA, Wang et al 2003 S4 genes pass two-wayANOVA P0 T28F4.5 T28F4.5 T28F4.5; T28F4.5.1; T28F4.5.2; 1I69; CE06527; WBGene00012140; WP:CE06527 The T28F4.5 gene encodes a homolog of Death Associated Protein 1 (DAP-1) protein that may be involved in apoptosis. Murphy et al 2003 Fig2 Class1 elongate lifespan, ViswanathanM et al 2005 S2 sir-2.1 regulated VC5.3 VC5.3 npa-1; VC5.3; VC5.3b.1; VC5.3b.2; 5H561; CE21224; CE33332; CE36211; NM_072394; NM_182438; WBGene00003786; WP:CE21224; WP:CE33332; WP:CE36211 npa-1 encodes a large polyprotein precursor that is posttranslationally cleaved to multiple units of ~14.5kDa, each of which is a strong binding protein for fatty acids and retinol (Vitamin A); the lipid binding sites of NPA-1-derived peptides are unusually apolar; NPA-1-derived peptides probably are carrier proteins that enable distribution of these lipids within nematodes; NPA-1-derived peptides are also secreted by parasitic nematode species. Murphy et al 2003 Fig2 Class1 elongate lifespan, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, list of genes in cluster C VZK822L.1 VZK822l.1 fat-6; VZK822L.1; 4M678; CE18302; NM_069854; WBGene00001398; WP:CE18302 fat-6 encodes a delta-9 fatty acid desaturase that is predicted to be mitochondrial. acyl-CoA desaturase McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph W01B11.6 W01B11.6 W01B11.6; W01B11.6a.1; W01B11.6a.2; 1D862; CE26952; WBGene00020917; WP:CE26952 Murphy et al 2003 Fig2 Class1 elongate lifespan, ViswanathanM et al 2005 S2 sir-2.1 regulated, ViswanathanM et al 2005 S2 daf-16 Resveratrol W02D3.1 W02D3.1 W02D3.1; W02D3.1.1; W02D3.1.2; 1H317; CE14418; WBGene00020931; WP:CE14418 cytochrome B5 McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Murphy et al 2003 Fig2 Class1 elongate lifespan, ViswanathanM et al 2005 S2 sir-2.1 regulated W03D2.6 W03D2.6 W03D2.6; 4E822; CE33718; WBGene00020981; WP:CE33718 Murphy et al 2003 Fig2 Class1 elongate lifespan, Reinke et al 2004, mixed sperm soma, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, fem3 enriched genes, ViswanathanM et al 2005 S2 daf-16 Resveratrol W03F11.3 W03F11.3 W03F11.3; 1C802; CE28502; WBGene00021006; WP:CE28502 Jones et al 2001 Dauer specific genes P<0.05, Murphy et al 2003 Fig2 Class1 elongate lifespan, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, spermatogenesis enriched genes, Reinke et al 2004, fem3 enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, wt males vs glp4 male enriched , Reinke et al 2004, list of genes in cluster D, Reinke et al 2004, shared sperm, ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S8 SAGE genes in the dauer exit, Wang et al 2003 S7 SAGE genes in the dataset W05H9.1 W05H9.1 W05H9.1; W05H9.1.1; W05H9.1.2; CE05036; WBGene00021048; WP:CE05036; XG891 Murphy et al 2003 Fig2 Class1 elongate lifespan, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, list of genes in cluster B, ViswanathanM et al 2005 S2 sir-2.1 regulated, Zhang et al 2002, T1 mec-3 dependent genes, Zhang et al. 2002, Fig2b overexpressed in mec-3MT W06D12.3 W06D12.3 fat-5; W06D12.3; 5S205; CE16551; NM_075081; WBGene00001397; WP:CE16551 fat-5 encodes a delta-9 fatty acid desaturase that is predicted to be mitochondrial; when expressed heterologously in S. cerevisiae, FAT-5 rescues the fatty acid auxotrophy of the yeast delta-9 desaturase mutant ole1. Fatty acid desaturase Murphy et al 2003 Fig2 Class1 elongate lifespan W06D4.1 W06D4.1 hgo-1; W06D4.1; 1J626; CE29602; HGO; NM_060032; WBGene00001843; WP:CE29602 hgo-1 is orthologous to the human gene SIMILAR TO HOMOGENTISATE 1,2-DIOXYGENASE (HOMOGENTISATE OXIDASE) (HGD; OMIM:203500), which when mutated leads to disease. HOMOGENTISATE 1,2-DIOXYGENASE (EC 1.13.11.5) (HOMOGENTISICASE) (HOMOGENTISATE OXYGENASE) (HOMOGENTISIC ACID OXIDASE) McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Murphy et al 2003 Fig2 Class1 elongate lifespan, ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S4 Climbing, Wang et al 2003 S3 genes pass one-way ANOVA, Wang et al 2003 S4 genes pass two-wayANOVA P0 W07E6.6 W07E6.6 W07E6.6; WBGene00021077 Murphy et al 2003 Fig2 Class1 elongate lifespan, Wang et al 2003 S3 genes pass one-way ANOVA, Wang et al 2003 S4 Dauer Enriched, Wang et al 2003 S4 genes pass two-wayANOVA P0 W08D2.4 W08D2.4 fat-3; W08D2.4; 4K569; CE25153; NM_069351; WBGene00001395; WP:CE25153 The fat-3 gene encodes a delta-6 fatty acid desaturase ('linoleoyl-CoA desaturase') containing an N-terminal cytochrome b5 domain; FAT-3 expressed in yeast uses linoleic and alpha-linolenic acid as substrates; FAT-3 is absolutely required in vivo for synthesis of delta-6 fatty acids, and also required for fully normal synthesis of C20 fatty acids; FAT-3 is required for a normally fast growth rate and movement speed, and for normal defecation rhythms and fertility. Murphy et al 2003 Fig2 Class1 elongate lifespan, Reinke et al 2004, list of genes in cluster A, Reinke et al 2004, list of genes in cluster order, ViswanathanM et al 2005 S2 sir-2.1 regulated W10G6.3 W10G6.3 ifa-2; mua-6; W10G6.3; W10G6.3.1; W10G6.3.2; CE18354; Cel IF A2; CelIF a2; NM_078247; WBGene00003485; WP:CE18354; XQ878 mua-6 encodes an essential intermediate filament protein (MUA-6/IFA-2) that is coexpressed with the essential IF protein IFB-1; MUA-6 is required for hypodermal integrity and for lasting attachment of muscles to the body wall; MUA-6 is also required for normal positioning of excretory canals and muscles; MUA-6 forms heteropolymeric intermediate filaments in vitro with an equimolar mixture of IFB-1; mua-6 is transcribed from L1 larval to adult stages; MUA-6 resides in main body hypodermal desmosomes, but not in seam cells. intermediate filament protein Murphy et al 2003 Fig2 Class1 elongate lifespan, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, list of genes in cluster C, Reinke et al 2004, IVb male soma enriched genes, Wang et al 2003 S4 Climbing, Wang et al 2003 S3 genes pass one-way ANOVA, Wang et al 2003 S4 genes pass two-wayANOVA P0 Y105C5A.12 Y105C5A.12 Y105C5A.12; 4Q402; CE23193; WBGene00013636; WP:CE23193 Murphy et al 2003 Fig2 Class1 elongate lifespan Y15E3A.5 Y15E3A.5 Y15E3A.5; CE31634; WBGene00012444; WP:CE31634; XP963 Murphy et al 2003 Fig2 Class1 elongate lifespan, Shen et al 2005 T1 hif-1 depend hypoxia, Wang et al 2003 S3 genes pass one-way ANOVA, Wang et al 2003 S4 Dauer Enriched, Wang et al 2003 S4 genes pass two-wayANOVA P0 Y32H12A.8 Y32H12A.8 Y32H12A.8; 3G476; CE28516; WBGene00021316; WP:CE28516 McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Murphy et al 2003 Fig2 Class1 elongate lifespan, ViswanathanM et al 2005 S2 sir-2.1 regulated Y39G8B.7 Y39G8B.7 Y39G8B.7; 2O282; CE24248; WBGene00012727; WP:CE24248 Murphy et al 2003 Fig2 Class1 elongate lifespan Y40B10A.2 Y40B10A.2 Y40B10A.2; 5C541; CE21796; WBGene00021487; WP:CE21796 Murphy et al 2003 Fig2 Class1 elongate lifespan, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, list of genes in cluster C, ViswanathanM et al 2005 S2 sir-2.1 regulated Y40B10A.6 Y40B10A.6 Y40B10A.6; 5C522; CE21794; WBGene00021491; WP:CE21794 Murphy et al 2003 Fig2 Class1 elongate lifespan, ViswanathanM et al 2005 S2 sir-2.1 regulated Y43C5A.3 Y43C5A.3 Y43C5A.3; 4L37; CE19152; WBGene00012783; WP:CE19152 Lund et al 2002 Fig4 Mount 15, Murphy et al 2003 Fig2 Class1 elongate lifespan, ViswanathanM et al 2005 S2 sir-2.1 regulated, ViswanathanM et al 2005 S2 daf-16 Resveratrol Y43C5B.2 Y43C5B.2 Y43C5B.2; 4L116; CE19157; WBGene00012785; WP:CE19157 Src homology domain 2, tyrosine-protein kinase Murphy et al 2003 Fig2 Class1 elongate lifespan, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, spermatogenesis enriched genes, Reinke et al 2004, fem3 enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, wt males vs glp4 male enriched , Reinke et al 2004, list of genes in cluster D, Reinke et al 2004, GO categories, Reinke et al 2004, shared sperm Y43F8A.3 Y43F8A.3 Y43F8A.3; 5T853; CE38569; WBGene00012810; WP:CE38569 Murphy et al 2003 Fig2 Class1 elongate lifespan, ViswanathanM et al 2005 S2 sir-2.1 regulated, ViswanathanM et al 2005 S2 daf-16 Resveratrol, Wang et al 2003 S3 genes pass one-way ANOVA, Wang et al 2003 S4 Dauer Enriched, Wang et al 2003 S4 genes pass two-wayANOVA P0 Y46C8AR.1 Y46C8AR.1 clec-76; Y46C8AR.1; Y46C8AR.1.1; Y46C8AR.1.2; 4E733; CE31650; WBGene00021587; WP:CE31650 Murphy et al 2003 Fig2 Class1 elongate lifespan, Reinke et al 2004, herm soma enriched genes, ViswanathanM et al 2005 S2 sir-2.1 regulated Y46H3A.3 Y46H3A.3 hsp-16.2; Y46H3A.3; Y46H3A.D; 5C282; CE22002; NM_071106; WBGene00002016; WP:CE22002 hsp-16.2 encodes a 16-kD heat shock protein (HSP) that is a member of the hsp16/hsp20/alphaB-crystallin (HSP16) family of heat shock proteins; hsp-16.2 expression, strongest in intestine and pharynx, is induced in response to heat shock or other environmental stresses; HSP-16.2 has been shown to interact with intracellular human beta amyloid peptide, a primary component of the extracellular plaques found in Alzheimer's disease; HSP-16.2 is likely to function as a passive ligand temporarily preventing unfolded proteins from aggregating. heat shock protein Golden et al 2004, N2 differentially expressed gen, Golden et al 2004, daf-2 differentially expressed , Link et al 2003 T3 Abeta highly induced, Link et al 2003 T2 Abeta induced, Murphy et al 2003 Fig2 Class1 elongate lifespan, Romagnolo et al 2002 Fig2a heat shock, ViswanathanM et al 2005 S2 sir-2.1 regulated Y51A2B.1 Y51A2B.1 Y51A2B.1; 5S847; CE16655; WBGene00013065; WP:CE16655 Murphy et al 2003 Fig2 Class1 elongate lifespan Y51A2D.11 Y51A2D.11 Y51A2D.11; 5T40; CE19207; WBGene00013079; WP:CE19207 Transthyretin-like family Murphy et al 2003 Fig2 Class1 elongate lifespan, Reinke et al 2004, list of genes in cluster A, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, GO categories, Reinke et al 2004, IVb male soma enriched genes, ViswanathanM et al 2005 S2 daf-16 Resveratrol Y51B9A.8 Y51B9A.8 Y51B9A.8; 2J689; CE19218; WBGene00013090; WP:CE19218 Murphy et al 2003 Fig2 Class1 elongate lifespan, ViswanathanM et al 2005 S2 sir-2.1 regulated Y53G8B.1 Y53G8B.1 Y53G8B.1; 3E219; CE25427; WBGene00021817; WP:CE25427 Murphy et al 2003 Fig2 Class1 elongate lifespan Y54G11A.6 Y54G11A.6 ctl-1; Y54G11A.6; 2O592; CE30713; NM_064578; WBGene00000830; WP:CE30713; cat2 ctl-1 encodes a cytoplasmic catalase. catalase Jones et al 2001 T2 lifespan and Dauer, Murphy et al 2003 Fig2 Class1 elongate lifespan, ViswanathanM et al 2005 S2 sir-2.1 regulated Y56A3A.33 Y56A3A.33 Y56A3A.33; 3N90; CE24469; WBGene00013244; WP:CE24469 McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Murphy et al 2003 Fig2 Class1 elongate lifespan, Wang et al 2003 S3 genes pass one-way ANOVA, Wang et al 2003 S4 Dauer Enriched, Wang et al 2003 S4 genes pass two-wayANOVA P0 Y57G11C.14 Y57G11C.14 Y57G11C.14; 4P565; CE14952; WBGene00013310; WP:CE14952 Murphy et al 2003 Fig2 Class1 elongate lifespan, Reinke et al 2004, male sperm, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, wt herm vs wt herm enriched gen, Reinke et al 2004, fem3 enriched genes, Reinke et al 2004, wt males vs glp4 male enriched , Reinke et al 2004, mixed sperm soma, Reinke et al 2004, list of genes in cluster D, ViswanathanM et al 2005 S2 sir-2.1 regulated Y67A6A.2 Y67A6A.2 nhr-62; Y67A6A.2; 1K419; CE27305; NM_060206; WBGene00003652; WP:CE27305 nuclear hormone receptor Murphy et al 2003 Fig2 Class1 elongate lifespan, Reinke et al 2004, mixed sperm soma, Reinke et al 2004, fem3 enriched genes Y6E2A.3 Y6E2A.3 Y6E2A.3; WBGene00043553 Lund et al 2002 Fig1 aging-regulated genes, Murphy et al 2003 Fig2 Class1 elongate lifespan Y71G12B.4 Y71G12B.4 Y71G12B.4; 1C283; CE26253; WBGene00022144; WP:CE26253 McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Murphy et al 2003 Fig2 Class1 elongate lifespan, Reinke et al 2004, list of genes in cluster A, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, IVb male soma enriched genes, ViswanathanM et al 2005 S2 sir-2.1 regulated ZC247.1 ZC247.1 ZC247.1; 1K842; CE39535; WBGene00013859; WP:CE39535 Murphy et al 2003 Fig2 Class1 elongate lifespan, ViswanathanM et al 2005 S2 sir-2.1 regulated ZC395.5 ZC395.5 ZC395.5; 3G357; CE01441; WBGene00022597; WP:CE01441 Murphy et al 2003 Fig2 Class1 elongate lifespan, Reinke et al 2004, list of genes in cluster A, Reinke et al 2004, list of genes in cluster order, Romagnolo et al 2002 Fig3b Unkown, Romagnolo et al 2002 Fig5 genes in let-60 timecour, ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S3 genes pass one-way ANOVA, Wang et al 2003 S4 genes pass two-wayANOVA P0, Wang et al 2003 S4 Dauer Enriched ZC410.5 ZC410.5 ZC410.5; 4J855; CE15209; CE35703; WBGene00013882; WP:CE15209; WP:CE35703 microfilarial antigen like Murphy et al 2003 Fig2 Class1 elongate lifespan, ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S3 genes pass one-way ANOVA, Wang et al 2003 S4 Dauer Enriched, Wang et al 2003 S4 genes pass two-wayANOVA P0 ZC47.9 ZC47.9 fbxa-33; ZC47.9; 3C369; WBGene00013841 Murphy et al 2003 Fig2 Class1 elongate lifespan ZK1320.2 ZK1320.2 ZK1320.2; ZK1320.2.1; ZK1320.2.2; 2J948; CE01700; WBGene00014252; WP:CE01700 Murphy et al 2003 Fig2 Class1 elongate lifespan, ViswanathanM et al 2005 S2 sir-2.1 regulated ZK355.3 ZK355.3 ZK355.3; 2D216; CE23458; WBGene00022713; WP:CE23458 Murphy et al 2003 Fig2 Class1 elongate lifespan, ViswanathanM et al 2005 S2 daf-16 Resveratrol, Wang et al 2003 S6 removed genes of contamination ZK384.1 ZK384.1 ZK384.1; 5T207; CE16722; WBGene00013971; WP:CE16722 SCP-like extracellular Proteins Murphy et al 2003 Fig2 Class1 elongate lifespan, ViswanathanM et al 2005 S2 sir-2.1 regulated ZK384.2 ZK384.2 ZK384.2; 5T208; CE16723; WBGene00013972; WP:CE16723 SCP-like extracellular Proteins (2 domains) Jones et al 2001 Dauer specific genes P<0.05, Murphy et al 2003 Fig2 Class1 elongate lifespan, Wang et al 2003 S7 SAGE genes in the dataset, Wang et al 2003 S8 SAGE genes in the dauer exit ZK384.3 ZK384.3 ZK384.3; 5T204; CE20430; WBGene00013973; WP:CE20430 Eukaryotic aspartyl proteases McElwee et al 2003 Fig4 daf-16 target lifspan, Murphy et al 2003 Fig2 Class1 elongate lifespan ZK54.2 ZK54.2 tag-25; tps-1; ZK54.2; ZK54.2b.1; ZK54.2b.2; ZK54.2b.3; CE07617; CE30330; NM_078430; WBGene00006602; WP:CE07617; WP:CE30330; XS82 trehalose phophate synthase Murphy et al 2003 Fig2 Class1 elongate lifespan, Reinke et al 2004, wt herm vs wt male enriched gen, ViswanathanM et al 2005 S2 sir-2.1 regulated, ViswanathanM et al 2005 S2 daf-16 Resveratrol ZK550.6 ZK550.6 ZK550.6; ZK550.6.1; ZK550.6.2; 4S204; CE20432; WBGene00014000; WP:CE20432 The ZK550.6 gene encodes an ortholog of the human gene PHYTANOYL-COA HYDROXYLASE (PHYH; PAHX; OMIM:602026), which when mutated leads to Refsum disease (OMIM:266500). Murphy et al 2003 Fig2 Class1 elongate lifespan, Reinke et al 2004, mixed sperm soma, Reinke et al 2004, fem3 enriched genes, Reinke et al 2004, IVb male soma enriched genes ZK973.5 ZK973.5 acr-6; ZK973.5; 1E927; CE24751; NM_058953; WBGene00000045; WP:CE24751 acetylcholine receptor subunit Murphy et al 2003 Fig2 Class1 elongate lifespan ZK973.7 ZK973.7 ZK973.7; WBGene00043974 Murphy et al 2003 Fig2 Class1 elongate lifespan, ViswanathanM et al 2005 S2 sir-2.1 regulated