Gene name Source Gene ID Annotation Date Added by
C12C8.1 C12C8.1 P W All gene names: hsp-70; C12C8.1; 1J898; CE08110;
NM_060084; WBGene00002026; WP:CE08110
WormBase description: hsp-70 encodes a member of the
hsp70 family.
WormBase CDS description: heat shock protein 70
Member of lists (Publications lists):
Custodia et al 2001 T2 heat shock,
GuhaThakurta et al 2002 T1 upregu on heat stress,
Jones et al 2001 Dauer specific genes P<0.05, Kwon et
al 2004 T1 Class1 rapid-induction Ethanol, Lund et al
2002 Aging time course Fig2C heatshock, Lund et al 2002
Fig1 aging-regulated genes, Romagnolo et al 2002
Fig2a heat shock, Shen et al 2005 T1 hif-1indepen
hypoxia, ViswanathanM et al 2005 S2 UPR genes,
ViswanathanM et al 2005 S2 sir-2.1 regulated,
ViswanathanM et al 2005 Fig6A Ethanol HS, Wang et al
2003 S8 SAGE genes in the dauer exit, Wang et al 2003
S7 SAGE genes in the dataset
C14F11.5 C14F11.5 P W All gene names: hsp-43; C14F11.5; CE03986; HSP43;
NM_076644; WBGene00002024; WP:CE03986; XG852
WormBase description: hsp-43 encodes a member of the
hsp20 family.
WormBase CDS description: heat shock protein
Member of lists (Publications lists):
Reinke et al 2004, list of genes in
cluster order, Romagnolo et al 2002 Fig2a heat shock,
ViswanathanM et al 2005 S2 sir-2.1 regulated,
ViswanathanM et al 2005 S2 daf-16 Resveratrol, Wang et
al 2003 S3 genes pass one-way ANOVA, Wang et al 2003
S4 Dauer Enriched, Wang et al 2003 S4 genes pass
two-wayANOVA P0
C15H9.6 C15H9.6 P W All gene names: hsp-3; C15H9.6; C15H9.6.1; C15H9.6.2;
C15H9.6.3; CE08177; NM_076618; WBGene00002007;
WP:CE08177; XG708
WormBase description: hsp-3 encodes a heat shock
response 70 (hsp70) protein orthologous to human
glucose regulated protein 78 (grp78/BiP, OMIM:138120);
HSP-3 likely functions as a molecular chaperone, and is
expressed constitutively (expression is not heat
inducible) throughout development with greatest
abundance during the L1 larval stage; HSP-3 contains a
long hydrophobic amino terminus and a carboxyl terminal
KDEL sequence suggesting that it may be retained in the
endoplasmic reticulum.
WormBase CDS description: heat shock protein
Member of lists (Publications lists):
McCarroll et al 2004 SFig5 conserved
w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/
Drosoph, Reinke et al 2004, list of genes in cluster
order, Reinke et al 2004, list of genes in cluster C,
Romagnolo et al 2002 Fig2a heat shock
C30C11.4 C30C11.4 P W All gene names: C30C11.4; C30C11.4.1; C30C11.4.2;
3J534; CE00103; WBGene00016250; WP:CE00103
WormBase description: Msi3p
Member of lists (Publications lists):
GuhaThakurta et al 2002 T1 upregu on
heat stress, Kwon et al 2004 T1 late-induction
Ethanol-response, Lund et al 2002 Aging time course
Fig2C heatshock, McCarroll et al 2004 SFig5 conserved
w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/
Drosoph, Reinke et al 2004, intrinsic, Reinke et al
2004, wt vs glp-4 enriched genes, Romagnolo et al 2002
Fig2a heat shock, ViswanathanM et al 2005 S2 sir-2.1
regulated, ViswanathanM et al 2005 Fig6A Ethanol HS
C37H5.8 C37H5.8 P W All gene names: hsp-6; mot-2; C37H5.8; 5F304; CE08631;
NM_071890; WBGene00002010; WP:CE08631
WormBase description: hsp-6 encodes a
mitochondrial-specific chaperone that is a member of
the DnaK/Hsp70 superfamily of molecular chaperones;
hsp-6 is believed to be involved in the mitochondrial
unfolded protein response, as hsp-6 expression,
normally broadly detected from the L1 larval through
adult stages of development, is greatly increased in
response to treatments that disrupt mitochondrial
protein handling; loss of hsp-6 activity via RNAi
results in severe growth defects with arrest at
embryonic and early larval stages of development.
WormBase CDS description: heat shock 70 protein
Member of lists (Publications lists):
Lund et al 2002 Aging time course
Fig2C heatshock, McCarroll et al 2004 SFig5 conserved
w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/
Drosoph, Romagnolo et al 2002 Fig2a heat shock,
ViswanathanM et al 2005 S2 sir-2.1 regulated
C47E8.5 C47E8.5 P W All gene names: daf-21; tax-3; C47E8.5; C47E8.5.1;
C47E8.5.2; C47E8.5.3; 5P167; CE05441; NM_074225;
WBGene00000915; WP:CE05441
WormBase description: daf-21 encodes a member of the
Hsp90 family of molecular chaperones; DAF-21 activity
is required for larval development, negative regulation
of dauer larva formation, and a number of specific
chemosensory behaviors, such as the response to
chemicals and odorants detected by the ASE and AWC
sensory neurons; a daf-21 sensory defect can be rescued
by a cyclic GMP analogue, suggesting that, in
regulating chemosensory behaviors, DAF-21 acts at a
similar point as the DAF-11 guanylyl cyclase;
down-regulation of daf-21 via RNAi results in a small
but reproducible reduction in age-1 life span,
suggesting that daf-21 is part of a chaperone network
required for the extended life span seen in age-1
mutant animals.
WormBase CDS description: heat shock protein (HSP90)
Member of lists (Publications lists):
Lund et al 2002 Aging time course
Fig2C heatshock, McCarroll et al 2004 SFig5 conserved
w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/
Drosoph, Reinke et al 2004, intrinsic, Reinke et al
2004, wt vs glp-4 enriched genes, Romagnolo et al 2002
Fig2a heat shock, ViswanathanM et al 2005 S2 sir-2.1
regulated
F08H9.3 F08H9.3 P W All gene names: F08H9.3; 5O942; CE09267;
WBGene00008591; WP:CE09267
WormBase description: F08H9.3 encodes a heat shock
protein (HSP) of the HSP16 class; unlike most HSP16s in
C. elegans, it is specifically expressed in a
particular tissue (the larval pharynx and the anterior
adult pharynx), and its expression is not strongly
induced by heat shock; however, F08H9.3 expression is
increased by heat shock (with adult expression in the
full pharynx) and probably aids heat shock resistance,
since F08H9.3(RNAi) animals have sensitivity to heat
shock that is sporadically higher than normal; in
general, HSP16 proteins are thought to act as passive
ligands for unfolded proteins that keep them safe from
aggregation until the proteins can be refolded by a
large (ATP-consuming) HSP.
WormBase CDS description: heat shock protein
Member of lists (Publications lists):
Kwon et al 2004 T1 Class1
rapid-induction Ethanol, Lund et al 2002 Aging time
course Fig2C heatshock, Lund et al 2002 Fig4 Mount 15,
Romagnolo et al 2002 Fig2a heat shock
F08H9.4 F08H9.4 P W All gene names: F08H9.4; 5O946; CE09268;
WBGene00008592; WP:CE09268
WormBase description: F08H9.4 encodes a heat shock
protein (HSP) of the HSP16 class; unlike most HSP16s in
C. elegans, it is specifically expressed in a
particular tissue (the excretory canal and ventral
nerve-cord neurons), and its expression is only mildly
induced by heat shock; however, F08H9.4 expression is
increased by heat shock, is induced in a new tissue
type (intestine) by heat shock, and probably aids heat
shock resistance, since F08H9.4(RNAi) animals die as
embryos in heat shock at a higher rate than normal; in
general, HSP16 proteins are thought to act as passive
ligands for unfolded proteins that keep them safe from
aggregation until the proteins can be refolded by a
large (ATP-consuming) HSP.
WormBase CDS description: heat shock protein
Member of lists (Publications lists):
Jones et al 2001 Dauer specific genes
P<0.05, Kwon et al 2004 T1 Class1 rapid-induction
Ethanol, Lund et al 2002 Aging time course Fig2C
heatshock, Romagnolo et al 2002 Fig2a heat shock, Shen
et al 2005 T1 hif-1indepen hypoxia, Wang et al 2003
S8 SAGE genes in the dauer exit, Wang et al 2003 S6
removed genes of contamination, Wang et al 2003 S7
SAGE genes in the dataset
F26D10.3 F26D10.3, T28F3.2 P W All gene names: hsp-1; F26D10.3; F26D10.3.1;
F26D10.3.2; F26D10.3.3; T28F3.2; 4S223; CE09682;
NM_070667; WBGene00002005; WP:CE09682
WormBase description: hsp-1 encodes hsp70A, a member of
the heat shock family of proteins; hsp70A is closely
related to the Drosophila heat inducible hsp70s and the
S. cerevisiae SSA hsp70 subfamily; the hsp-1 gene is
normally expressed throughout development and upon
heat-shock the hsp-1 mRNA is enhanced 2-6 fold;
down-regulation of hsp-1 via RNA interference results
in a small reduction in the life-span of an age-1
mutant indicating that hsp-1 may play some role in
regulating longevity.
WormBase CDS description: HSP-1 heat shock 70kd protein
A
Member of lists (Publications lists):
Custodia et al 2001 T2 heat shock,
Lund et al 2002 Aging time course Fig2C heatshock,
McCarroll et al 2004 SFig5 conserved w/ yeast,
McCarroll et al 2004 SFig1-4 conserved w/ Drosoph,
Reinke et al 2004, intrinsic, Reinke et al 2004, wt vs
glp-4 enriched genes, Romagnolo et al 2002 Fig2a heat
shock, ViswanathanM et al 2005 S2 sir-2.1 regulated
F39B2.10 F39B2.10 P W All gene names: dnj-12; F39B2.10; F39B2.10.1;
F39B2.10.2; F39B2.10.3; F39B2.10.4; 1P351; CE16015;
NM_061169; WBGene00001030; WP:CE16015
WormBase description: This gene encodes a protein
containing a DnaJ ('J') domain.
WormBase CDS description: DnaJ, prokaryotic heat shock
protein
Member of lists (Publications lists):
Lund et al 2002 Aging time course
Fig2C heatshock, McCarroll et al 2004 SFig5 conserved
w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/
Drosoph, Romagnolo et al 2002 Fig2a heat shock,
ViswanathanM et al 2005 S2 sir-2.1 regulated
F43D9.4 F43D9.4 P W All gene names: sec-1; sip-1; F43D9.4; F43D9.4.1;
F43D9.4.2; 3L596; CE00994; NM_066915; SIP/1;
WBGene00004798; WP:CE00994
WormBase description: Heat shock hsp20 proteins
Member of lists (Publications lists):
ReichertK et al 2005 T3 xenobiotic
downregulated, Reinke et al 2004, Fig2b shared
gemlines, Reinke et al 2004, list of genes in cluster
order, Reinke et al 2004, intrinsic, Reinke et al 2004,
wt vs glp-4 enriched genes, Reinke et al 2004, wt males
vs glp4 male enriched , Reinke et al 2004, list of
genes in cluster E, Romagnolo et al 2002 Fig2a heat
shock, ViswanathanM et al 2005 S2 sir-2.1 regulated
F43E2.8 F43E2.8 P W All gene names: hsp-4; F43E2.8; F43E2.8.1; F43E2.8.2;
2H640; CE07244; NM_063135; WBGene00002008; WP:CE07244
WormBase description: hsp-4 encodes a predicted homolog
of the mammalian ER chaperone BiP that affects
embryonic and larval viability; expression is most
prominent in the spermatheca and transcription of hsp-4
is induced in the gut and in the hypodermis upon ER
stress.
WormBase CDS description: heat shock protein
Member of lists (Publications lists):
Kwon et al 2004 T1 late-induction
Ethanol-response, Romagnolo et al 2002 Fig2a heat
shock, ViswanathanM et al 2005 S2 sir-2.1 regulated,
ViswanathanM et al 2005 S2 UPR genes
F44E5.4 F44E5.4 P W All gene names: F44E5.4; F44E5.4.1; F44E5.4.2; 2M48;
CE18679; WBGene00009691; WP:CE18679
WormBase description: Heat shock hsp70 proteins
Member of lists (Publications lists):
Custodia et al 2001 T2 heat shock,
GuhaThakurta et al 2002 T1 upregu on heat stress, Lund
et al 2002 Aging time course Fig2C heatshock, Reinke et
al 2004, list of genes in cluster order, Reinke et al
2004, list of genes in cluster B, Romagnolo et al 2002
Fig2a heat shock, Shen et al 2005 T1 hif-1indepen
hypoxia, ViswanathanM et al 2005 S2 sir-2.1 regulated
F44E5.5 F44E5.5 P W All gene names: F44E5.5; F44E5.5.1; F44E5.5.2; 2M51;
WBGene00009692
WormBase description: Heat shock hsp70 proteins
Member of lists (Publications lists):
Custodia et al 2001 T2 heat shock,
GuhaThakurta et al 2002 T1 upregu on heat stress, Lund
et al 2002 Aging time course Fig2C heatshock, Reinke et
al 2004, list of genes in cluster order, Reinke et al
2004, list of genes in cluster B, Romagnolo et al 2002
Fig2a heat shock, Shen et al 2005 T1 hif-1indepen
hypoxia, ViswanathanM et al 2005 S2 sir-2.1 regulated
F52E1.7 F52E1.7 P W All gene names: hsp-17; F52E1.7; HSP17.5; 5I862;
CE04635; CE35323; WBGene00002021; WP:CE04635;
WP:CE35323
WormBase description: hsp-17 encodes a heat shock
protein that is a member of the
hsp16/hsp20/alpha-crystallin family of heat shock
proteins; by homology, HSP-17 is predicted to function
as a molecular chaperone that protects cells from
heat-induced protein aggregation and denaturation; at
present, the precise developmental and/or behavioral
role of HSP-17, as well as its expression pattern, are
not yet known.
Member of lists (Publications lists):
McCarroll et al 2004 SFig1-4
conserved w/ Drosoph, Reinke et al 2004, list of genes
in cluster order, Reinke et al 2004, list of genes in
cluster C, Romagnolo et al 2002 Fig2a heat shock,
ViswanathanM et al 2005 S2 daf-16 Resveratrol,
ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et
al 2003 S3 genes pass one-way ANOVA, Wang et al 2003
S4 Climbing, Wang et al 2003 S4 genes pass
two-wayANOVA P0
F54C9.2 F54C9.2 P W All gene names: stc-1; F54C9.2; 2I854; CE32895;
NM_063407; STCH; WBGene00006059; WP:CE32895
WormBase description: Heat shock 70Kd protein (HSP70)
Member of lists (Publications lists):
Kwon et al 2004 T1 late-induction
Ethanol-response, Lund et al 2002 Aging time course
Fig2C heatshock, Romagnolo et al 2002 Fig2a heat
shock, ViswanathanM et al 2005 S2 sir-2.1 regulated
K09C4.3 K09C4.3 P W All gene names: hsp-2; hsp-2ps; K09C4.3; NM_076166;
WBGene00002006; XD911
Member of lists (Publications lists):
Custodia et al 2001 T2 heat shock,
Romagnolo et al 2002 Fig2a heat shock
R09E12.3 R09E12.3 P W All gene names: R09E12.3; 5B253; CE12646;
WBGene00019983; WP:CE12646
Member of lists (Publications lists):
Lund et al 2002 Aging time course
Fig2C heatshock, McCarroll et al 2004 SFig5 conserved
w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/
Drosoph, Reinke et al 2004, intrinsic, Reinke et al
2004, wt vs glp-4 enriched genes, Romagnolo et al 2002
Fig2a heat shock, ViswanathanM et al 2005 S2 sir-2.1
regulated
R151.7 R151.7 P W All gene names: R151.7; R151.7a.1; R151.7a.2; 3I314;
CE39621; CE39622; WBGene00020110; WP:CE39621;
WP:CE39622
WormBase description: HSP C62.5
Member of lists (Publications lists):
Lund et al 2002 Aging time course
Fig2C heatshock, McCarroll et al 2004 SFig1-4
conserved w/ Drosoph, Reinke et al 2004, intrinsic,
Reinke et al 2004, wt vs glp-4 enriched genes, Reinke
et al 2004, wt herm vs wt male enriched gen, Romagnolo
et al 2002 Fig2a heat shock, ViswanathanM et al 2005
S2 sir-2.1 regulated
T05C3.5 C24G6.5, T05C3.5 P W All gene names: dnj-19; T05C3.5; T05C3.5.1; T05C3.5.2;
CE13229; NM_072051; WBGene00001037; WP:CE13229
WormBase description: This gene encodes a protein
containing a DnaJ ('J') domain.
WormBase CDS description: DNAJ-like protein
Member of lists (Publications lists):
Lund et al 2002 Aging time course
Fig2C heatshock, Romagnolo et al 2002 Fig2a heat
shock, ViswanathanM et al 2005 S2 sir-2.1 regulated
T05E11.3 T05E11.3 P W All gene names: T05E11.3; T05E11.3.1; T05E11.3.2;
4L887; CE06362; WBGene00011480; WP:CE06362
WormBase description: endoplasmin precursor (GRP94)
Member of lists (Publications lists):
Lund et al 2002 Aging time course
Fig2C heatshock, McCarroll et al 2004 SFig1-4
conserved w/ Drosoph, Reinke et al 2004, list of genes
in cluster order, Reinke et al 2004, list of genes in
cluster C, Romagnolo et al 2002 Fig2a heat shock,
ViswanathanM et al 2005 S2 sir-2.1 regulated
T14G8.3 T14G8.3 P W All gene names: T14G8.3; CE37407; CE37408;
WBGene00011771; WP:CE37407; WP:CE37408; XN487
WormBase description: T14G8.3 encodes an ortholog of
hypoxia-upregulated vertebrate proteins such as human
HYOU1; T14G8.3, its C. elegans paralog T24H7.2, and
HYOU1 are ER resident hsp70 family molecular chaperone
homologs; the grp (glucose regulated protein) 170
family is a collection of related large hsp70
chaperones confined to the ER; members of this family
are present in all eukaryotes, participating in a wide
range of cellular functions.
WormBase CDS description: heat shock protein
Member of lists (Publications lists):
Lund et al 2002 Aging time course
Fig2C heatshock, Reinke et al 2004, list of genes in
cluster order, Reinke et al 2004, list of genes in
cluster C, Romagnolo et al 2002 Fig2a heat shock,
ViswanathanM et al 2005 S2 sir-2.1 regulated
T15H9.7 T15H9.1 P W All gene names: dnj-20; T15H9.7; 2J908; CE30690;
NM_171030; WBGene00001038; WP:CE30690
WormBase description: This gene encodes a protein
containing a DnaJ ('J') domain.
Member of lists (Publications lists):
Romagnolo et al 2002 Fig2a heat shock
T24H7.2 T24H7.2 P W All gene names: T24H7.2; T24H7.2.1; T24H7.2.2; 2G539;
CE02884; WBGene00020781; WP:CE02884
WormBase description: T24H7.2 encodes an ortholog of
hypoxia-upregulated vertebrate proteins such as human
HYOU1; T24H7.2, its C. elegans paralog T14G8.3, and
HYOU1 are ER resident hsp70 family molecular chaperone
homologs; the grp (glucose regulated protein) 170
family is a collection of related large hsp70
chaperones confined to the ER; members of this family
are present in all eukaryotes, participating in a wide
range of cellular functions.
Member of lists (Publications lists):
Lund et al 2002 Aging time course
Fig2C heatshock, McCarroll et al 2004 SFig1-4
conserved w/ Drosoph, Romagnolo et al 2002 Fig2a heat
shock, ViswanathanM et al 2005 S2 sir-2.1 regulated
T27E4.2 T27E4.2 P W All gene names: hsp-16.11; T27E4.2; 5J571; NM_072956;
WBGene00002017
WormBase description: hsp-16.11 encodes a 16-kD heat
shock protein (HSP) that is a member of the
hsp16/hsp20/alphaB-crystallin (HSP16) family of heat
shock proteins, and that is identical to the protein
encoded by hsp-16.1; hsp-16.11 expression is induced in
response to heat shock or other environmental stresses;
HSP-16.11 is likely to function as passive ligand
temporarily preventing unfolded proteins from
aggregating; HSP-16.11 has been shown to interact with
intracellular human beta amyloid peptide, a primary
component of the extracellular plaques found in
Alzheimer's disease.
WormBase CDS description: heat shock protein HSP16-1
Member of lists (Publications lists):
Golden et al 2004, N2 differentially
expressed gen, GuhaThakurta et al 2002 T1 upregu on
heat stress, Romagnolo et al 2002 Fig2a heat shock,
ViswanathanM et al 2005 S2 sir-2.1 regulated,
ViswanathanM et al 2005 S2 UPR genes, ViswanathanM et
al 2005 Fig6A Ethanol HS
T27E4.8 T27E4.8 P W All gene names: hsp-16.1; hsp-16; T27E4.8; 5J568;
CE14249; NM_072953; WBGene00002015; WP:CE14249
WormBase description: hsp-16.1 encodes a 16-kD heat
shock protein (HSP) that is a member of the
hsp16/hsp20/alphaB-crystallin (HSP16) family of heat
shock proteins, and that is identical to the protein
encoded by hsp-16.11; an hsp-16.1 reporter fusion,
expressed broadly but most strongly in muscle and
hypodermis, is induced solely in response to heat shock
or other environmental stresses; expression is
detectable in somatic tissues in post-gastrulation
embryos, all larval stages, and in adults; HSP-16.1 is
likely to function as a passive ligand temporarily
preventing unfolded proteins from aggregating.
WormBase CDS description: heat shock protein HSP16-1
Member of lists (Publications lists):
Murphy et al 2003 Fig2 Class1
elongate lifespan, Romagnolo et al 2002 Fig2a heat
shock, ViswanathanM et al 2005 S2 sir-2.1 regulated
Y46H3A.3 Y46H3A.D P W All gene names: hsp-16.2; Y46H3A.3; Y46H3A.D; 5C282;
CE22002; NM_071106; WBGene00002016; WP:CE22002
WormBase description: hsp-16.2 encodes a 16-kD heat
shock protein (HSP) that is a member of the
hsp16/hsp20/alphaB-crystallin (HSP16) family of heat
shock proteins; hsp-16.2 expression, strongest in
intestine and pharynx, is induced in response to heat
shock or other environmental stresses; HSP-16.2 has
been shown to interact with intracellular human beta
amyloid peptide, a primary component of the
extracellular plaques found in Alzheimer's disease;
HSP-16.2 is likely to function as a passive ligand
temporarily preventing unfolded proteins from
aggregating.
WormBase CDS description: heat shock protein
Member of lists (Publications lists):
Golden et al 2004, N2 differentially
expressed gen, Golden et al 2004, daf-2 differentially
expressed , Link et al 2003 T3 Abeta highly induced,
Link et al 2003 T2 Abeta induced, Murphy et al 2003
Fig2 Class1 elongate lifespan, Romagnolo et al 2002
Fig2a heat shock, ViswanathanM et al 2005 S2 sir-2.1
regulated
