Steina et al 2007, Muscle enriched genes, 50 genes Gene list file name: Stetina2007_supp6 Type of gene identifier: Cosmid name Description: the 50 top ranked muscle-enriched genes Organism: Caenorhabditis elegans (nematode) Gene list type: Experimental Gene name Source Gene ID All gene names WormBase description WormBase CDS description Proteome description Member of lists () Other annotations B0273.1 B0273.1 B0273.1; 4G259; CE16787; WBGene00015097; WP:CE16787 B0416.7 B0416.7 B0416.7; CE02437; CE39552; WBGene00015182; WP:CE02437; WP:CE39552; XJ914 C02C2.5 C02C2.5 C02C2.5; 3I966; CE34519; WBGene00015334; WP:CE34519 C29F5.1 C29F5.1 C29F5.1; 2G595; CE02508; WBGene00016210; WP:CE02508 C32E12.4 C32E12.4 C32E12.4; 1F800; CE30496; WBGene00016330; WP:CE30496 C41C4.2 C41C4.2 sre-2; C41C4.2; 2I392; CE37883; NM_063297; WBGene00005150; WP:CE37883 7TM receptor, sre family C44B7.4 C44B7.4 C44B7.4; 2H160; CE34753; WBGene00016626; WP:CE34753 C50F2.4 C50F2.4 C50F2.4; 1E456; CE08910; WBGene00016838; WP:CE08910 F08F3.10 F08F3.10 F08F3.10; 5F891; CE32855; WBGene00017266; WP:CE32855 F19B10.1 F19B10.1 F19B10.1; 2D975; CE09468; O02076_CAEEL; WBGene00017583; WP:CE09468 F21D9.4 F21D9.4 F21D9.4; 5T723; CE18630; WBGene00009018; WP:CE18630 F28H1.2 F28H1.2 cpn-3; F28H1.2; 1E557; CE09767; NM_058881; WBGene00000779; WP:CE09767 cpn-3 encodes a calponin homolog, most closely related to its paralog CPN-4 in C. elegans; CPN-3 is more similar to the calponin paralogs transgelin (SM22 alpha) or neuronal protein NP25 than to calponin per se. calponin F29F11.4 F29F11.4 twk-12; F29F11.4; 5L149; CE37366; NM_073330; WBGene00006667; WP:CE37366 twk-12 encodes one of 44 C. elegans TWK (two-P domain K+) potassium channel subunits that contain two pore-forming domains and four transmembrane domains; as loss of TWK-12 function via RNA-mediated interference (RNAi) does not result in any abnormalities, the precise role of TWK-12 in C. elegans development and/or behavior is not yet known; TWK-12 may, however, function redundantly with other TWK channels; the TWK-12 expression pattern has not been determined. potassium channel protein like F46G10.6 F46G10.6 hlh-23; mxl-3; F46G10.6; CE05882; NM_077822; WBGene00003511; WP:CE05882; XN968 Helix-loop-helix DNA-binding domain F53A3.7 F53A3.7 F53A3.7; 3D41; CE23764; WBGene00018723; WP:CE23764 F55C5.5 F55C5.5 EF-TS; tsfm-1; F55C5.5; 5M750; CE11158; WBGene00010094; WP:CE11158 F55C5.5 encodes a translational elongation factor Ts (EF-Ts) that binds two different EF-Tu proteins (EF-TU1/Y71H2AM.23 and EF-TU2/C43E11.4) in vitro, stimulating guanine-nucleotide exchange and mRNA translation; F55C5.5 is predicted to be mitochondrial and has a putative N-terminal transit peptide sequence; F55C5.5 is required in mass RNAi assays for normally rapid growth and for maintenance of the germline. mitochondrial elongation factor TS H22K11.4 H22K11.4 H22K11.4; CE37119; CE40082; WBGene00019227; WP:CE37119; WP:CE40082; XH406 H22K11.4 is orthologous to the human gene SARCOGLYCAN, ALPHA (50KD DYSTROPHIN-ASSOCIATED GLYCOPROTEIN) (SGCA; OMIM:600119), which when mutated leads to disease. K04D7.3 K04D7.3 gta-1; K04D7.3; 4K947; CE06092; NM_069461; WBGene00001794; WP:CE06092 The gta-1 gene encodes an ortholog of the human gene GABAT, which when mutated leads to GABA-transaminase deficiency (OMIM:137150). 4-aminobutyrate aminotransferase K08F4.7 K08F4.7 gst-4; K08F4.7; 4K907; CE06155; CeGST1; GST4_CAEEL; NM_069447; WBGene00001752; WP:CE06155 gst-4 encodes a predicted glutathione S-transferase; mRNA is expressed in adults and accumulation increases in response to paraquat. glutathione S-transferase R03E9.2 R03E9.2 R03E9.2; CE04785; WBGene00019843; WP:CE04785; XH350 R07C3.4 R07C3.4 R07C3.4; 2B221; CE12528; WBGene00019920; WP:CE12528 ATP-dependent AMP-binding protein R148.6 R148.6 heh-1; tag-79; R148.6; 3E288; CE31057; NM_065270; WBGene00006452; WP:CE31057 tag-79/R148.6 is orthologous to human NPC2 (OMIM:601015, mutated in Niemann-Pick disease type C2) R173.1 R173.1 cah-5; R173.1; CE36560; NM_076785; WBGene00000283; WP:CE36560; XH641 cah-5 encodes a member of the carbonic anhydrase family. carbonic anhydrase T04F8.1 T04F8.1 T04F8.1; CE03614; WBGene00011440; WP:CE03614; XM278 T07H6.4 T07H6.4 T07H6.4; CE04914; WBGene00020331; WP:CE04914; XG900 sushi repeats T13H10.1 T13H10.1 kin-5; T13H10.1; 4K732; CE06444; NM_069392; WBGene00002193; WP:CE06444 kin-5 encodes a predicted protein tyrosine kinase that is most closely related to the non-receptor tyrosine kinases Fes/Fps and Fer that contain an SH2 domain and a tyrosine kinase domain (OMIM:190030, murine Fes appears to be required for hemopoietic homeostasis); as loss of kin-5 activity via large-scale RNAi screens does not result in any obvious abnormalities, the precise role of kin-5 in C. elegans development and/or behavior is not yet known. Src homology domain 2, tyrosine-protein kinase (FES/FPS subfamily) T19D2.3 T19D2.3 T19D2.3; CE07516; WBGene00020568; WP:CE07516; XE559 T21B6.3 T21B6.3 T21B6.3; CE31621; Q22631_CAEEL; WBGene00011880; WP:CE31621; XL564 The protein product of this gene is predicted to contain a glutamine/asparagine (Q/N)-rich ('prion') domain, by the algorithm of Michelitsch and Weissman (as of the WS77 release of WormBase, i.e., in wormpep77). f-spondin like protein T22H2.4 T22H2.4 T22H2.4; 1M288; CE14002; WBGene00011934; WP:CE14002 T28D9.4 T28D9.4 T28D9.4; 2G769; CE36024; CE39787; WBGene00020896; WP:CE36024; WP:CE39787 Y116F11A.6 Y116F11A.6 Y116F11A.6; 5U197; CE24159; WBGene00013819; WP:CE24159 Y19D10A.15 Y19D10A.15 srd-75; Y19D10A.15; 5C875; WBGene00044099 7TM chemoreceptor, srd family Y19D10A.4 Y19D10A.4 Y19D10A.4; 5C871; WBGene00021219 Y38F1A.2 Y38F1A.2 Y38F1A.2; 2N247; CE21607; WBGene00012606; WP:CE21607 Zinc finger, C3HC4 type (RING finger) Y47D3B.7 Y47D3B.7 hlh-20; lpd-1; sbp-1; Y47D3B.7; 3M518; CE19180; NM_067071; Q9XX00_CAEEL; WBGene00004735; WP:CE19180 sbp-1 encodes a basic helix-loop-helix (bHLH) transcription factor homologous to the mammalian Sterol Regulatory Element Binding Proteins (SREBPs, OMIM:184756, overexpression of nuclear form of SREBP-1c is associated with insulin resistance and features of congenital generalized lipodystrophy); in C. elegans, SBP-1 activity is required for normal lipid metabolism and wild-type levels of lipogenic enzyme expression, as well as for embryonic and larval development; sbp-1 expression is detected exclusively in the intestine, the major site of fat storage, from early embryogenesis through adulthood. Helix-loop-helix DNA-binding domain Y51A2D.14 Y51A2D.14 Y51A2D.14; 5T63; CE19210; WBGene00013081; WP:CE19210 Y54G2A.29 Y54G2A.29 Y54G2A.29; Y54G2A.B; 4D788; CE34416; WBGene00021893; WP:CE34416 Y71H2AM.15 Y71H2AM.15 Y71H2AM.15; 3D838; CE27319; CE39069; Q9BL41_CAEEL; WBGene00022180; WP:CE27319; WP:CE39069 Y73F8A.26 Y73F8A.26 Y73F8A.26; 4Q241; CE25594; WBGene00013531; WP:CE25594 Y75B7AR.1 Y75B7AR.1 Y75B7AR.1; 5B870; CE27416; WBGene00022287; WP:CE27416 ZC374.2 ZC374.2 ZC374.2; CE03804; WBGene00013872; WP:CE03804; XK654 Fibronectin type III domain (4 domains) ZK643.1 ZK643.1 ZK643.1; 3K25; CE00440; WBGene00014033; WP:CE00440