|Gene list file name:||Stetina2007_supp19|
|Type of gene identifier:||Cosmid name|
|Description:||Genes enriched in both Embryonic and Larval A-class neurons classified and grouped by category|
|Organism:||Caenorhabditis elegans (nematode)|
|Gene list type:||Experimental|
Gene name Source Gene ID Annotation Date Added by
B0034.3 B0034.3 P W All gene names: casy-1; cdh-11; B0034.3; 2G236; CE27048; CE27049; CE39540; NM_062788; Q9BIB5_CAEEL; WBGene00000403; WP:CE27048; WP:CE27049; WP:CE39540 WormBase description: A homolog of a member of the cadherin superfamily which is involved in cell-cell adhesion.
B0041.3 B0041.3 P W All gene names: B0041.3; 1F213; CE07668; WBGene00015008; WP:CE07668
B0250.2 B0250.2 P W All gene names: B0250.2; 5U948; CE18479; WBGene00007119; WP:CE18479
B0350.2 B0350.2 P W All gene names: unc-44; B0350.2; 4G769; CE06702; CE06704; CE31147; CE31847; CE35821; CE37694; CE37695; Q17490_CAEEL; WBGene00006780; WP:CE06702; WP:CE06704; WP:CE31147; WP:CE31847; WP:CE35821; WP:CE37694; WP:CE37695 WormBase description: The unc-44 gene encodes an ankyrin-like protein required for proper sex myoblast and axonal guidance during development.
B0478.1 B0478.1 P W All gene names: jnk-1; sak-1; B0478.1; 4H727; CE27574; CE30123; JNK1_CAEEL; NM_171371; WBGene00002178; WP:CE27574; WP:CE30123 WormBase description: jnk-1 encodes a serine/threonine kinase that is the sole C. elegans member of the c-Jun N-terminal kinase (JNK) subgroup of mitogen-activated protein (MAP) kinases; JNK-1 exhibits kinase activity in vitro that is dependent upon activation by the JKK-1 MAPKK; a JNK-1::GFP translational fusion protein is expressed in nearly all neuronal cell bodies and processes, including the nerve ring, head and tail ganglions, and the dorsal and ventral nerve cords, at all stages of development.
C03C10.6 C03C10.6 P W All gene names: C03C10.6; CE30720; NM_065416; WBGene00007272; WP:CE30720
C03G5.7 C03G5.7 P W All gene names: flp-5; C03G5.7; CE06760; NM_077044; WBGene00001448; WP:CE06760; XJ149 WormBase description: flp-5 encodes a predicted FMRFamide-like peptide neurotransmitter that increases action potential frequency in the pharyngeal muscle when applied to the pharynx of dissected worms; expressed in the sensory neurons ASE and PVM.
C05B5.7 C05B5.7 P W All gene names: rgs-1; C05B5.7; 3L104; CE27794; NM_066820; WBGene00004344; WP:CE27794 WormBase description: rgs-1 encodes a regulator of G protein signaling; by homology, RGS-1 is predicted to function as a GTPase-activating protein for heterotrimeric G-protein alpha-subunits, and in vitro RGS-1 can stimulate the GTPase activity of purified GOA-1; in vivo, rgs-1 appears to function redundantly with rgs-2 to regulate egg-laying behavior when animals are refed following starvation; rgs-1 is expressed in most or all neurons. WormBase CDS description: 1r20 protein (human)
C05E11.3 C05E11.3 P W All gene names: C05E11.3; CE33029; WBGene00015494; WP:CE33029; XF199
C11D2.6 C11D2.6 P W All gene names: nca-1; C11D2.6; 4G922; CE31301; CE37194; CE37195; CE37196; NM_068525; NM_068526; NM_171352; NM_171353; WBGene00003557; WP:CE31301; WP:CE37194; WP:CE37195; WP:CE37196
C11H1.7 C11H1.7 P W All gene names: C11H1.7; CE18492; WBGene00007531; WP:CE18492; XO945
C13A10.2 C13A10.2 P W All gene names: C13A10.2; 2B648; CE08124; WBGene00015729; WP:CE08124
C13G3.2 C13G3.2 P W All gene names: hot-6; C13G3.2; 5L502; CE05278; NM_073405; WBGene00001991; WP:CE05278
C17D12.5 C17D12.5 P W All gene names: C17D12.5; 1M179; CE30492; WBGene00007639; WP:CE30492
C17G10.4 C17G10.4 P W All gene names: cdc-14; C17G10.4; 2F878; CDC14_CAEEL; CE06845; CE08287; CE08288; CE30868; CE36916; NM_062683; WBGene00000383; WP:CE06845; WP:CE08287; WP:CE08288; WP:CE30868; WP:CE36916; cdc14 WormBase description: cdc-14 encodes a dual-specificity phosphatase, homologous to Cdc14p in S. cerevisiae; CDC-14 localizes to the central spindle in anaphase and to the midbody in telophase, and is required for cytokinesis and embryonic viability.
C17H12.10 C17H12.10 P W All gene names: C17H12.10; 4H573; CE16870; WBGene00015935; WP:CE16870
C18A3.6 C18A3.6 P W All gene names: rab-3; rbl-3; C18A3.6; 2G12; CE20518; CE23555; RAB3/A; WBGene00004267; WP:CE20518; WP:CE23555; rab3 WormBase description: rab-3 encodes a rab3 homolog, a member of the Ras GTPase superfamily, and affects sensitivity to aldicarb and the distribution of synaptic vesicle populations and thereby affects synaptic transmission, track amplitude and speed of movement, chemotaxis to isoamyl alcohol, affects pharyngeal pump durations, and may only slightly affect male mating behavior; requires aex-3 for localization to synapse-rich regions in axons and it is expressed in most or all neurons. WormBase CDS description: synaptic vesicle-associated GTP-binding protein
C18C4.10 C18C4.10 P W All gene names: klc-2; C18C4.10; 5G58; CE27362; CE32802; CE32803; CE36917; KLC_CAEEL; WBGene00002215; WP:CE27362; WP:CE32802; WP:CE32803; WP:CE36917 WormBase description: klc-2 encodes a kinesin light chain and was identified as a protein that interacts with UNC-16 by the yeast two-hybrid system, this association suggests that KLC-2 may be involved in the regulation of synaptic vesicle localization by the UNC-16-JNK signaling complex.
C18D1.3 C18D1.3 P W All gene names: flp-4; C18D1.3; 2K345; CE01503; NM_063772; WBGene00001447; WP:CE01503 WormBase description: FMRFamide-like peptide
C26D10.6 C26D10.6 P W All gene names: C26D10.6; 2I640; CE32806; WBGene00007746; WP:CE32806
C27H5.1 C27H5.1 P W All gene names: pdl-1; C27H5.1; 2H473; CE01175; NM_063089; WBGene00003966; WP:CE01175
C27H6.1 C27H6.1 P W All gene names: apt-10; C27H6.1; 5K448; CE08425; NM_073165; WBGene00000167; WP:CE08425 WormBase description: apt-10 encodes the C. elegans ortholog of the mammalian Stonins and Drosophila Stoned B, membrane-associated proteins that contain three distinct domains: a proline-rich domain, a stonin homology domain, and a domain paralogous to the mu-adaptin subunits of adaptor protein complexes 1-3; by homology, APT-10 is predicted to regulate the activity of the heteromeric AP-1 and AP-2 clathrin adaptor protein complexes, and thus to play a role in intracellular protein trafficking and endocytosis; in vivo, apt-10 is required for the secretion of EGL-17/FGF, required for sex myoblast migration, from the vulval precursor cell P6.p; loss of apt-10 activity via large-scale RNAi screens, however, does not result in any obvious abnormalities. WormBase CDS description: Adaptor complexes medium subunit family
C32E8.10 C32E8.10 P W All gene names: unc-11; C32E8.10; 1E368; CE23562; CE23564; CE23565; CE23566; CE24822; CE27812; CE27813; PICA_CAEEL; WBGene00006751; WP:CE23562; WP:CE23564; WP:CE23565; WP:CE23566; WP:CE24822; WP:CE27812; WP:CE27813 WormBase description: unc-11 encodes multiple isoforms of a clathrin-adaptor protein AP180 (OMIM:603025) that functions in clathrin-mediated endocytosis; UNC-11 is essential for embryogenesis, locomotion, and pharyngeal pumping, and regulates neurotransmitter release by controlling vesicle trafficking and fusion; UNC-11 is also required for localization of SNB-1/synaptobrevin to synaptic vesicles, thus acting as a sorting protein as well as a clathrin-adaptor protein; UNC-11 is expressed at high levels in nearly all neurons, where it is enriched at presynaptic terminals, and is also expressed in coelomocytes, the uv1 secretory cells of the vulva, and the intestine.
C32E8.7 C32E8.7 P W All gene names: ric-19; C32E8.7; 1E346; CE39089; NM_058815; RIC19_CAEEL; WBGene00004368; WP:CE39089 WormBase description: The ric-19 gene encodes an evolutionarily conserved cytosolic protein involved in neuroendocrine secretion via association with secretory vesicles.
C33C12.9 C33C12.9 P W All gene names: C33C12.9; 2C478; CE27815; WBGene00016341; WP:CE27815
C33F10.5 C33F10.5 P W All gene names: rig-6; tag-227; C33F10.5; 2F90; CE04138; CE25803; CE31679; CE37327; NM_062460; NM_062461; NM_170981; WBGene00016354; WP:CE04138; WP:CE25803; WP:CE31679; WP:CE37327 WormBase description: fibronectin, IG-like domains of NCAM
C35A11.1 C35A11.1 P W All gene names: C35A11.1; 5F885; CE37616; WBGene00016428; WP:CE37616
C38H2.1 C38H2.1 P W All gene names: C38H2.1; 3L461; CE32601; WBGene00008018; WP:CE32601 WormBase description: Probable rabGAP domains
C39F7.1 C39F7.1 P W All gene names: C39F7.1; 5B741; CE16904; WBGene00016538; WP:CE16904
C41G11.3 C41G11.3 P W All gene names: rgs-6; C41G11.3; CE30895; WBGene00004349; WP:CE30895; XG340 WormBase description: rgs-6 encodes a regulator of G protein signaling; by homology, RGS-6 is predicted to function as a GTPase-activating protein that binds G protein alpha subunits and negatively regulates heterotrimeric G protein signaling; loss of rgs-6 activity via RNAi or a deletion mutation results in no obvious defects, and likewise, rgs-6 overexpression has no measurable effect on egg-laying behavior, locomotion, or viability; the rgs-6 expression pattern has not yet been reported.
C43H6.3 C43H6.3 P W All gene names: C43H6.3; CE06954; WBGene00016616; WP:CE06954; XD27
C47E8.3 C47E8.3 P W All gene names: C47E8.3; 5P161; CE40832; WBGene00008142; WP:CE40832
C52B9.1 C52B9.1 P W All gene names: cka-2; C52B9.1; CE27113; CE38493; NM_076333; WBGene00000510; WP:CE27113; WP:CE38493; XE909
Loading lists: 90 wallclock secs (12.10 usr + 0.76 sys = 12.86 CPU) secs WormBase description: cka-2 encodes an isoform of choline kinase whose activity has been verified in vitro; CKA-1 and CKA-2 comprise a related group ('A') of choline kinases; purified CKA-2 is dimeric, requires 1 mM Mg(2+) for optimal activity, and has a strong preference for choline over ethanolamine; CKA-2 has a pH optimum of 10 and a k(cat) of 74/s, close to the maximum rate observed for yeast and rat enzymes.
C54G4.5 C54G4.5 P W All gene names: C54G4.5; 1I573; CE23613; WBGene00008315; WP:CE23613
C55B7.2 C55B7.2 P W All gene names: gly-2; C55B7.2; 1H87; CE27887; NM_059473; WBGene00001627; WP:CE27887 WormBase description: gly-2 encodes a functional homolog of mammalian UDP-N-acetylglucosamine alpha-6-d-mannoside beta-1,6-N-acetylglucosaminyltransferase V (GlcNAc-TV) which regulates polylactosamine-containing N-glycans; gly-2 is functionally interchangeable with the mammalian gene; GLY-2 is expressed in late embryos and in a subset of neurons in larvae, spermathecal and pharyngeal-intestinal valves and in specific vulval cells of adults. WormBase CDS description: alpha-1,3(6)-mannosylglycoprotein beta-1,6-N-acetyl-glucosaminyltransferase
E03D2.2 E03D2.2 P W All gene names: nlp-9; E03D2.2; 5E699; CE16959; CE27903; NM_071767; NM_071768; WBGene00003747; WP:CE16959; WP:CE27903
F07H5.4 F07H5.4 P W All gene names: F07H5.4; 2J77; WBGene00014308
F08B6.2 F08B6.2 P W All gene names: gpc-2; F08B6.2; 1H335; CE20656; NM_059534; WBGene00001682; WP:CE20656 WormBase description: gpc-2 encodes one of two C. elegans heterotrimeric G protein gamma subunits; gpc-2 is required, along with its partner GPB-1, a G protein beta subunit, for proper mitotic spindle positioning and orientation during early embryonic cell divisions; to date, GPC-2 expression has been reported in electrically excitable cells (all neurons and muscles).
F08D12.12 F08D12.12 P W All gene names: F08D12.12; 2D72; CE37221; WBGene00017255; WP:CE37221
F08F3.1 F08F3.1 P W All gene names: F08F3.1; 5F925; CE40758; WBGene00017260; WP:CE40758
F08G5.4 F08G5.4 P W All gene names: col-130; F08G5.4; 4N192; CE05574; NM_069971; WBGene00000704; WP:CE05574 WormBase description: collagen
F09C3.2 F09C3.2 P W All gene names: F09C3.2; 1O862; CE36126; WBGene00008610; WP:CE36126 WormBase description: haloacid dehalogenase-like hydrolase
F09G8.5 F09G8.5 P W All gene names: F09G8.5; 3J345; CE00526; WBGene00017320; WP:CE00526
F10E7.9 F10E7.9 P W All gene names: F10E7.9; 2H398; CE04364; WBGene00017350; WP:CE04364 WormBase description: bumetanide-sensitive Na-K-Cl cotransporter
F10F2.4 F10F2.4 P W All gene names: F10F2.4; 3F717; CE31471; WBGene00008656; WP:CE31471 WormBase description: 2 leucine rich domains
F11F1.7 F11F1.7 P W All gene names: F11F1.7; 3O495; CE15807; WBGene00008719; WP:CE15807 WormBase description: Transthyretin-like family
F13B12.5 F13B12.5 P W All gene names: aho-2; ins-1; F13B12.5; 4L201; CE27955; ILP1; NM_069525; WBGene00002084; WP:CE27955 WormBase description: ins-1 encodes an insulin-like peptide orthologous to human insulin (INS; OMIM:176730, mutated in hyperproinsulinemia and diabetes mellitus type II); INS-1 is one of 38 insulin-like peptides in C. elegans and when overexpressed can antagonize insulin-like signaling mediated by DAF-2/IR leading to arrest at the dauer larval stage; loss of INS-1, however, does not result in a dauer phenotype suggesting that INS-1 functions redundantly with other insulin-like peptides to regulate reproductive growth and lifespan; INS-1 is expressed in the amphid sensory neurons ASI and ASJ that regulate dauer arrest, the nerve ring, the intestine, vulval muscles, and other neurons.
F13C5.1 F13C5.1 P W All gene names: F13C5.1; CE19383; WBGene00017422; WP:CE19383; XB223
F15A8.5 F15A8.5 P W All gene names: dop-1; F15A8.5; CE33615; CE33616; CE33617; CE33618; CEDOP1; WBGene00001052; WP:CE33615; WP:CE33616; WP:CE33617; WP:CE33618; XF30
F15G9.1 F15G9.1 P W All gene names: F15G9.1; CE01549; CE23660; CE32382; WBGene00008865; WP:CE01549; WP:CE23660; WP:CE32382; XK325
F20D1.7 F20D1.7 P W All gene names: F20D1.7; CE31487; WBGene00008977; WP:CE31487; XP604 WormBase description: Leucine Rich Repeat (2 copies) (4 domains)
F21A3.7 F21A3.7 P W All gene names: F21A3.7; 5P990; CE40944; WBGene00008997; WP:CE40944
F21F3.5 F21F3.5 P W All gene names: tmr-2; unc-38; F21F3.5; 1F466; CE24908; NM_059071; WBGene00006774; WP:CE24908 WormBase description: unc-38 encodes a nicotinic acetylcholine receptor (nAChR) alpha subunit; UNC-38 is required for normal locomotion and egg-laying, and functions as a subunit of a ligand-gated ion channel that likely mediates fast actions of acetylcholine at neuromuscular junctions and in the nervous system; when coexpressed with ACR-2, ACR-3, UNC-29, and LEV-1, non-alpha nAChR subunits, the resulting multimer can form levamisole-gated channels; UNC-38 is expressed postsynaptically in muscles and neurons where it colocalizes with TAX-6, and with ACR-8, ACR-12, and UNC-29, respectively. WormBase CDS description: ligand-gated ionic channel
F26C11.2 F26C11.2 P W All gene names: ceh-4; unc-4; F26C11.2; 2K188; CE01560; NM_063737; UNC4_CAEEL; WBGene00006744; WP:CE01560 WormBase description: The unc-4 gene encodes a paired-class homeodomain protein with homologs in Drosophila and vertebrates; UNC-4 is required for establishing the identity of the A class motor neurons DA and VA, and is thus required for movement, axon guidance, and synapse formation; UNC-4 is negatively regulated by VAB-7, and UNC-4 activity requires UNC-37; unc-4 is expressed in the A-type motor neurons, DA and VA, the six VC motor neurons that innervate the vulval muscles, and the three SAB motor neurons; unc-4 is also expressed in the pharyngeal I5 motor neuron and the AVF neurons in the retrovesicular ganglion. WormBase CDS description: homeobox protein (otd subfamily)
F27D9.1 F27D9.1 P W All gene names: lan-2; unc-18; unc-19; F27D9.1; CE04449; CE24927; CE34004; NM_076897; WBGene00006757; WP:CE04449; WP:CE24927; WP:CE34004; XI303 WormBase description: unc-18 encodes an ortholog of Saccharomyces cervisiae SEC1 that enables the docking of vesicles to synaptic regions before vesicle priming and fusion, and thus promotes synaptic vesicle exocytosis; UNC-18 may also inhibit excessive exocytosis.
F29A7.4 F29A7.4 P W All gene names: F29A7.4; 2D41; CE36835; WBGene00017914; WP:CE36835
F29G6.2 F29G6.2 P W All gene names: F29G6.2; CE09792; Q93635_CAEEL; WBGene00009258; WP:CE09792; XM128
F29G9.6 F29G9.6 P W All gene names: dhs-17; F29G9.6; 5G508; CE27376; CE40050; NM_072160; WBGene00000980; WP:CE27376; WP:CE40050 WormBase description: dhs-17 encodes a member of the short-chain dehydrogenases/reductases family (SDR).
F31B12.1 F31B12.1 P W All gene names: plc-1; F31B12.1; CE28227; CE31494; CE31495; NM_077404; PLC210; WBGene00004036; WP:CE28227; WP:CE31494; WP:CE31495; XL414 WormBase description: plc-1 encodes a predicted phospholipase C that affects fertility and possesses two functional domains not commonly seen in other phospholipases: a C-terminal Ras-associating domain with structural similarity to RalGDS and AF-6, and an N-terminal CDC25-like domain that possesses structural homology to guanine nucleotide exchange proteins for Ras. WormBase CDS description: phosphoinositide-specific phospholipase C
F31E8.2 F31E8.2 P W All gene names: ric-2; snt-1; unc-121; F31E8.2; 2H105; CE02711; CE28229; NM_062993; WBGene00004921; WP:CE02711; WP:CE28229; syt1 WormBase description: Synaptotagmin
F32B5.7 F32B5.7 P W All gene names: F32B5.7; 1D242; CE30526; WBGene00017980; WP:CE30526
F32B6.11 F32B6.11 P W All gene names: F32B6.11; 5L387; CE20744; WBGene00009325; WP:CE20744
F33D4.3 F33D4.3 P W All gene names: flp-13; F33D4.3; 4I462; CE17033; FLP13_CAEEL; NM_068854; WBGene00001456; WP:CE17033
F35A5.8 F35A5.8 P W All gene names: erp-1; F35A5.8; CE04492; CE29787; NM_171657; NM_171658; WBGene00001335; WP:CE04492; WP:CE29787; XE420 WormBase description: erp-1 is homologous to the human gene endophilin B1 (also called SH3GLB1, for SH3 domain GRB2-like endophilin B1).
F35C12.2 F35C12.2 P W All gene names: ncx-4; F35C12.2; 1K387; CE28020; CE40052; NM_060203; WBGene00003569; WP:CE28020; WP:CE40052 WormBase description: Na/Ca,K exchanger
F35C8.3 F35C8.3 P W All gene names: jkk-1; sek-2; F35C8.3; CE24941; NM_076512; Q9UAH1_CAEEL; WBGene00002177; WP:CE24941; XF989 WormBase description: jkk-1 encodes a member of the MAP kinase kinase superfamily that affects synaptic vesicle localization and is required in type-D motor neurons for normal locomotion; can function in the Hog1 MAP kinase pathway I in yeast as an activator of JNK and is expressed in most neurons
F35D2.5 F35D2.5 P W All gene names: syd-1; F35D2.5; 2H876; CE33069; CE33391; CE33392; NM_063191; WBGene00006363; WP:CE33069; WP:CE33391; WP:CE33392 WormBase description: transcriptional activator HAP4 and regulatory domain of BCR and P85A
F36A2.4 F36A2.4 P W All gene names: twk-30; F36A2.4; 1J386; CE34182; NM_059980; WBGene00006682; WP:CE34182 WormBase description: potassium channel protein
F37D6.6 F37D6.6 P W All gene names: tag-68; F37D6.6; 1L81; CE36156; WBGene00006445; WP:CE36156
F39B2.8 F39B2.8 P W All gene names: F39B2.8; CE30529; WBGene00009558; WP:CE30529
F41C6.1 F41C6.1 P W All gene names: unc-106; unc-6; F41C6.1; CE04538; NM_076764; WBGene00006746; WP:CE04538; XH515 WormBase description: unc-6 encodes a netrin orthologous to the human and mouse netrin-1 precursor proteins; UNC-6 functions as a guidance molecule that regulates the migrations of pioneer axons and mesodermal cells, such as the gonadal distal tip cell, along the dorsoventral axis; a secreted molecule, UNC-6 is expressed during embryogenesis by epidermoblasts and neurons; UNC-6 is involved in both attractive and repulsive interactions that are mediated by the UNC-40 and UNC-5 netrin receptors, respectively.
F41D9.1 F41D9.1 P W All gene names: F41D9.1; CE30984; WBGene00018281; WP:CE30984; XJ1
F43C9.4 F43C9.4 P W All gene names: mig-13; F43C9.4; CE28324; CE34562; NM_076419; WBGene00003245; WP:CE28324; WP:CE34562; XF416 WormBase description: mig-13 encodes a novel single-pass transmembrane protein with a N-terminal signal sequence and two motifs that have been implicated in protein-protein interactions: a CUB domain and a LDL receptor repeat; mig-13 affects the migration and thus the positioning of the Q neuroblasts and their descendants and also the anterior migration of the BDU neuron and may be a component of a global anterior/posterior migration system; a mig-13-gfp translational fusion protein is expressed in embryonic pharyngeal, hypodermal and anterior body neuronal precursors as well as in the cell bodies and axons of a number of neurons in the retrovascular ganglion and the ventral cord; mig-13 localizes to the plasma membrane; mig-13 expression along the A/P axis is restricted by hox gene activity.
F45H7.6 F45H7.6 P W All gene names: F45H7.6; 3E468; CE01588; WBGene00009738; WP:CE01588 WormBase description: Yeast ORF YKL162
F46A9.3 F46A9.3 P W All gene names: twk-29; F46A9.3; 1K45; CE32666; CE38354; WBGene00006681; WP:CE32666; WP:CE38354 WormBase description: potassium channel protein
F47D12.1 F47D12.1 P W All gene names: gar-2; F47D12.1; 3H409; CE01946; CE24987; CE30134; CE30135; CE32893; WBGene00001518; WP:CE01946; WP:CE24987; WP:CE30134; WP:CE30135; WP:CE32893 WormBase description: gar-2 encodes a novel, seven transmembrane-domain G protein-coupled acetylcholine receptor (AChR); when expressed in Xenopus oocytes treated with acetylcholine, GAR-2 is able to activate a mammalian G protein-activated inwardly rectifying K+ (GIRK1) channel, but not other channels, suggesting that GAR-2 couples to G proteins of the Gi family; pharmacological analyses indicate, however, that GAR-2 exhibits properties distinct from mammalian muscarinic AChRs; gar-2 is expressed from mid-embryogenesis through adulthood with expression seen in ciliated head neurons, ventral cord neurons, and the HSN (hermaphrodite-specific neuron). WormBase CDS description: G-protein-linked acetylcholine receptor GAR-2
F47D12.3 F47D12.3 P W All gene names: F47D12.3; 3H389; CE01947; WBGene00018560; WP:CE01947
F49E10.1 F49E10.1 P W All gene names: F49E10.1; CE29965; WBGene00018639; WP:CE29965; XG519
F49H12.4 F49H12.4 P W All gene names: F49H12.4; CE34564; WBGene00018655; WP:CE34564; XC697
F52A8.4 F52A8.4 P W All gene names: F52A8.4; 1H921; CE05911; WBGene00009917; WP:CE05911 WormBase description: globin like
F52D10.3 F52D10.3 P W All gene names: ftt-2; F52D10.3; CE03389; CE36489; NM_077537; NM_077538; Q95ZT1_CAEEL; WBGene00001502; WP:CE03389; WP:CE36489; XM222 WormBase description: 14-3-3 protein
F53B6.2 F53B6.2 P W All gene names: F53B6.2; 1J508; CE32429; CE36859; WBGene00009958; WP:CE32429; WP:CE36859 WormBase description: thrombospondin like
F54E4.4 F54E4.4 P W All gene names: F54E4.4; CE11080; WBGene00010060; WP:CE11080; XP260 WormBase description: zinc metalloprotease
F54G2.1 F54G2.1 P W All gene names: F54G2.1; CE34032; CE37652; WBGene00018837; WP:CE34032; WP:CE37652; XD240
F55C12.4 F55C12.4 P W All gene names: F55C12.4; 2G148; CE19468; WBGene00018871; WP:CE19468
F57B7.2 F57B7.2 P W All gene names: F57B7.2; 5L922; CE05990; WBGene00010192; WP:CE05990 WormBase description: SCP-like extracellular Proteins
F57F5.5 F57F5.5 P W All gene names: kin-13; pkc-1; ttx-4; F57F5.5; 5M496; CE29092; NM_073613; WBGene00004032; WP:CE29092 WormBase description: pkc-1 encodes a serine/threonine protein kinase that is orthologous to mammalian protein kinase C epsilon (PRKCE), a member of the nPKC subgroup of the protein kinase C superfamily; together with UNC-13, PKC-1 may act downstream of goa-1 to modulate phorbol ester-induced stimulation of acetylcholine release at NMJs; PKC-1 positively regulates locomotion, and affects thermotaxis and chemotaxis together with kin-11; PKC-1 is required for regulating several behaviors including sensation of volatile and soluble compounds, osmolarity, and temperature (thermosensation); PKC-1 is also required for phorbolester-induced stimulation of acetylcholine release at neuromuscular junctions; PKC-1 localizes to the processes and cell bodies of approximately 75 sensory neurons and interneurons, and pkc-1 mRNA is detectable at varying levels during larval and adult stages. WormBase CDS description: Phorbol esters / diacylglycerol binding domain (2 domains), Protein kinase C terminal domain
F58A3.4 F58A3.4 P W All gene names: F58A3.4; CE11358; WBGene00010224; WP:CE11358; XL626
F59B8.1 F59B8.1 P W All gene names: F59B8.1; 4K203; CE03435; CE11454; WBGene00010316; WP:CE03435; WP:CE11454
F59D12.1 F59D12.1 P W All gene names: F59D12.1; CE11490; WBGene00010329; WP:CE11490; XQ289 WormBase description: G-protein coupled receptor (gastrin/cholecystokinin)
H23L24.1 H23L24.1 P W All gene names: H23L24.1; 4J481; CE20982; WBGene00019228; WP:CE20982
K02E10.8 K02E10.8 P W All gene names: syg-1; K02E10.8; CE37121; NM_076056; WBGene00006365; WP:CE37121; XD128 WormBase description: syg-1 encodes a novel transmembrane protein that is a member of the immunoglobulin superfamily of proteins; during larval development, SYG-1 activity is required cell autonomously within the HSNL neuron to specify proper synaptic specificity with its targets, such as vulval muscles and the VC neuron; in regulating synapse formation, SYG-1 acts as a receptor for a second immunoglobulin superfamily protein, SYG-2, a synaptic guidepost protein that interacts with SYG-1 and whose activity is essential for proper SYG-1 localization in HSNL; expression of a SYG-1::GFP reporter fusion in HSNL under the control of the unc-86 promoter reveals that SYG-1 localizes to axons and accumulates at future sites of synaptic vesicle clustering, while expression under an endogenous reporter reveals weak expression in head motorneurons, occasionally in HSN neurons, and in other cells in the vulval region.
K02E2.6 K02E2.6 P W All gene names: K02E2.6; 5U851; CE23845; WBGene00010507; WP:CE23845
K06A5.8 K06A5.8 P W All gene names: K06A5.8; 1H54; CE31354; CE31355; CE33139; Q95X66_CAEEL; WBGene00019434; WP:CE31354; WP:CE31355; WP:CE33139
K07C11.7 K07C11.7 P W All gene names: K07C11.7; 5I688; CE28592; CE33142; WBGene00019479; WP:CE28592; WP:CE33142
K08E7.6 K08E7.6 P W All gene names: K08E7.6; 4N344; CE40366; WBGene00010674; WP:CE40366
K09E4.4 K09E4.4 P W All gene names: K09E4.4; 2O406; CE32692; WBGene00010722; WP:CE32692 WormBase description: K09E4.4 is orthologous to the human gene N-ACETYLGALACTOSAMINIDASE, ALPHA- (NAGLU; OMIM:104170), which when mutated leads to disease.
K10B3.6 K10B3.6 P W All gene names: K10B3.6; CE07369; CE34337; CE34338; WBGene00019612; WP:CE07369; WP:CE34337; WP:CE34338; XD726
K10D3.2 K10D3.2 P W All gene names: unc-14; K10D3.2; 1H700; CE25055; NM_059617; WBGene00006753; WP:CE25055 WormBase description: The unc-14 gene encodes an activity required for both axonogenesis and sex myoblast migration.
K11G12.2 K11G12.2 P W All gene names: acr-2; K11G12.2; CE07380; NM_076727; WBGene00000042; WP:CE07380; XH327 WormBase description: A homolog of a non-alpha type nicotinic acetylcholine receptor subunit that forms a functional channel when co-expressed with the unc-38 alpha subunit. WormBase CDS description: nicotinic acetylcholine receptor subunit
M01A8.2 M01A8.2 P W All gene names: M01A8.2; 3K350; CE33535; CE37262; WBGene00010796; WP:CE33535; WP:CE37262 WormBase description: CAP-Gly domain
M03E7.1 M03E7.1 P W All gene names: M03E7.1; 5G103; CE07394; WBGene00019753; WP:CE07394
R01E6.4 R01E6.4 P W All gene names: acr-12; R01E6.4; CE29334; NM_077861; WBGene00000051; WP:CE29334; XO153 WormBase description: acr-12 encodes a nicotinic acetylcholine receptor (nAChR) alpha subunit that is a member of the ACR-8-like group of C. elegans nAChR subunits; as an nAChR subunit, ACR-12 is predicted to mediate fast excitatory neurotransmission, however loss of acr-12 activity via mutation or RNAi results in no obvious defects; ACR-12 copurifies with UNC-29 and LEV-1, suggesting that ACR-12 can form receptors with these two non-alpha AChR subunits; an ACR-12::GFP fusion protein is expressed exclusively in ventral cord motor neurons, including the D neurons; in vivo, ACR-12 colocalizes with some, but not all, UNC-38-containing postsynaptic receptor clusters, suggesting that ACR-12 contributes to only a subset of these receptor clusters. WormBase CDS description: acetylcholine receptor protein
R03A10.2 R03A10.2 P W All gene names: flp-32; R03A10.2; CE06208; WBGene00010982; WP:CE06208; XQ53
R04F11.4 R04F11.4 P W All gene names: twk-13; twk-15; R04F11.4; 5M800; CE30561; NM_073690; WBGene00006668; WP:CE30561 WormBase description: twk-13 encodes one of 44 C. elegans TWK (two-P domain K+) potassium channel subunits that contain two pore-forming domains and four transmembrane domains; as loss of TWK-13 function via RNA-mediated interference (RNAi) does not result in any abnormalities, the precise role of TWK-13 in C. elegans development and/or behavior is not yet known; however, TWK-13 likely functions redundantly with other TWK channels; the TWK-13 expression pattern has not been determined. WormBase CDS description: potassium channel protein
R05G9.2 R05G9.2 P W All gene names: R05G9.2; 2G784; CE36000; CE37397; WBGene00019904; WP:CE36000; WP:CE37397
R07E4.6 R07E4.6 P W All gene names: kin-2; R07E4.6; CE04821; CE28749; CE39609; KAPR_CAEEL; NM_076598; WBGene00002190; WP:CE04821; WP:CE28749; WP:CE39609; XG588 WormBase description: kin-2 encodes a predicted regulatory subunit of a cAMP-dependent protein kinase that may act downstream of, or in parallel to, ric-8.
R09F10.5 R09F10.5 P W All gene names: R09F10.5; CE07439; WBGene00019988; WP:CE07439; XI922
R11H6.3 R11H6.3 P W All gene names: R11H6.3; 5P85; CE12774; WBGene00011251; WP:CE12774
R12H7.1 R12H7.1 P W All gene names: unc-9; R12H7.1; CE28246; NM_171790; WBGene00006749; WP:CE28246; XN833 WormBase description: unc-9 encodes an innexin, an integral transmembrane channel protein that is a structural component of invertebrate gap junctions; UNC-9 is required for normal forward locomotion and egg-laying and also plays a role in the response to antihelminthics and volatile anesthetics; UNC-9 may form a functional pair with UNC-7, another C. elegans innexin, as mutations in unc-7 result in defects nearly identical to those in unc-9 mutant animals. WormBase CDS description: UNC-7-like protein
T02C5.5 T02C5.5 P W All gene names: unc-2; T02C5.5; CE29459; CE31225; CE34591; CE34980; NM_171638; NM_171639; NM_171942; WBGene00006742; WP:CE29459; WP:CE31225; WP:CE34591; WP:CE34980; XD330 WormBase description: unc-2 encodes a calcium channel alpha subunit required for desensitization to dopamine, normal flexion and speed during movement, normally low sensitivity of whole animals to serotonin, and neuronal migrations promoted by humoral serotonin; UNC-2 is orthologous to human CACNA1A (OMIM:601011, mutated in familiar hemiplegic migraine or episodic ataxia 2) and to Drosophila CACOPHONY; UNC-2 is expressed primarily in motor neurons, several sensory neurons, and HSN and VC neurons controlling egg-laying.
T02E9.5 T02E9.5 P W All gene names: T02E9.5; 5L823; CE40116; WBGene00011383; WP:CE40116
T05C12.2 T05C12.2 P W All gene names: acr-14; T05C12.2; 2I462; CE25099; NM_063315; WBGene00000053; WP:CE25099 WormBase description: acr-14 encodes a protein that contains neurotransmitter-gated ion-channel ligand-binding and transmembrane domains. WormBase CDS description: neuronal acetylcholine receptor protein
T07A5.6 T07A5.6 P W All gene names: T07A5.6; 3L409; CE23955; CE38102; Q22276_CAEEL; WBGene00044098; WP:CE23955; WP:CE38102
T07C5.1 T07C5.1 P W All gene names: ugt-50; T07C5.1; CE18217; CE31603; WBGene00011564; WP:CE18217; WP:CE31603; XN313 WormBase description: PUTATIVE UDP-GLUCURONOSYLTRANSFERASE UGT16 PRECURSOR (EC 220.127.116.11) (UDPGT)
T08A9.3 T08A9.3 P W All gene names: sng-1; T08A9.3; CE21167; NM_076838; WBGene00004912; WP:CE21167; XH947; sng1 WormBase description: synaptogyrin
T10B5.4 T10B5.4 P W All gene names: T10B5.4; 5C348; CE28254; WBGene00020390; WP:CE28254
T14B4.8 T14B4.8 P W All gene names: T14B4.8; 2H10; CE39408; WBGene00020502; WP:CE39408
T20F10.5 T20F10.5 P W All gene names: T20F10.5; 1K878; CE35189; WBGene00011866; WP:CE35189
T22E5.1 T22E5.1 P W All gene names: T22E5.1; CE04991; CE39777; WBGene00020690; WP:CE04991; WP:CE39777; XH31
T23D8.2 T23D8.2 P W All gene names: tsp-7; T23D8.2; 1K546; CE26006; NM_060235; WBGene00006633; WP:CE26006 WormBase description: tetraspanin
T24F1.6 T24F1.6 P W All gene names: tag-180; T24F1.6; 2L614; CE36207; CE36208; WBGene00007041; WBGene00011998; WP:CE36207; WP:CE36208 WormBase description: calcium channel alpha-2 subunit
T27E4.1 T27E4.1 P W All gene names: T27E4.1; 5J573; CE29357; WBGene00020861; WP:CE29357
T27E9.9 T27E9.9 P W All gene names: acc-4; T27E9.9; 3O570; CE24020; WBGene00012099; WP:CE24020 WormBase description: ligand-gated ion channel
T28A8.1 T28A8.1 P W All gene names: twk-40; T28A8.1; 3O574; CE18972; NM_067389; WBGene00006691; WP:CE18972
W01H2.3 W01H2.3 P W All gene names: rab-37; W01H2.3; CE40138; CE40139; NM_076320; WBGene00004285; WP:CE40138; WP:CE40139; XE846 WormBase description: GTP-binding protein
W03G11.4 W03G11.4 P W All gene names: W03G11.4; CE18331; WBGene00012226; WP:CE18331; XM696
W04B5.2 W04B5.2 P W All gene names: W04B5.2; 3D515; CE20139; WBGene00021019; WP:CE20139
W05H12.2 W05H12.2 P W All gene names: W05H12.2; 1O0; CE14660; WBGene00012290; WP:CE14660
W06B11.1 W06B11.1 P W All gene names: W06B11.1; CE28508; WBGene00021059; WP:CE28508; XG469
W07E11.3 W07E11.3 P W All gene names: flp-2; flp-2a; flp-2b; W07E11.3; CE02374; CE28258; WBGene00001445; WP:CE02374; WP:CE28258; XK712 WormBase description: flp-2 encodes a predicted FMRFamide-like peptide neurotransmitter; expressed in the pharyngeal neuron I5.
W09H1.6 W09H1.6 P W All gene names: lec-1; W09H1.6; 2N489; CE16576; CE16577; NM_064400; O45904_CAEEL; WBGene00002264; WP:CE16576; WP:CE16577 WormBase description: lec-1 encodes a tandem repeat-type galectin in which each galectin domain is homologous to typical vertebrate 14-kDa-type galectins; the two sugar binding sites have distinct sugar binding properties in vitro and lec-1 is expressed most abundantly in the adult cuticle. WormBase CDS description: galectin
Y116F11A.6 Y116F11A.6 P W All gene names: Y116F11A.6; 5U197; CE24159; WBGene00013819; WP:CE24159
Y119C1B.3 Y119C1B.3 P W All gene names: Y119C1B.3; 1F117; CE37422; WBGene00022469; WP:CE37422
Y16B4A.1 Y16B4A.1 P W All gene names: unc-3; Y16B4A.1; CE29366; NM_078052; WBGene00006743; WP:CE29366; XP401 WormBase description: The unc-3 gene encodes a protein with homology to immunoglobulin (Ig) domain-containing transcription factors such as OLF-1 or SU(H). WormBase CDS description: transcription factor OLF-1 like
Y22D7AR.4 Y22D7AR.4 P W All gene names: Y22D7AR.4; 3C756; WBGene00021258
Y22F5A.3 Y22F5A.3 P W All gene names: ric-4; snap-25; Y22F5A.3; 5K742; CE32008; NM_073240; WBGene00004364; WBGene00012495; WP:CE32008 WormBase description: Y22F5A.3 encodes an ortholog of vertebrate SNAP-25 and S. cerevisiae Sec9p; SNAP-25 is associated with synaptosomes, required for axonal growth in vivo, and targeted by botulinum neurotoxins; UNC-86 and MEC-3 are required for Y22F5A.3 expression, and act on a regulatory element (I2h) in Y22F5A.3 conserved between the first introns of C. elegans and C. briggsae Y22F5A.3 genes; other conserved motifs in the promoter region (P1 and P2) and first intron (I1h, I1m, I2h, and I2m) are required for Y22F5A.3 expression in DA and DD motor neurons (P1), DB and DA neurons (I1m and I2m), amphid and phasmid neurons (P2), pharyngeal neurons (I1h), and mechanosensory neurons (I2h); Y22F5A.3 has no obvious function in mass RNAi assays WormBase CDS description: SNAP-25 family
Y38C1BA.2 Y38C1BA.2 P W All gene names: snn-1; ssn-1; Y38C1BA.2; 4C570; CE28520; CE31645; NM_171276; NM_171277; WBGene00004913; WP:CE28520; WP:CE31645; syn
Y39B6A.19 Y39B6A.19 P W All gene names: twk-46; Y39B6A.19; Y39B6B.F; 5T541; CE29861; NM_171588; WBGene00006696; WP:CE29861
Y39F10A.1 Y39F10A.1 P W All gene names: Y39F10A.1; 2B67; CE21725; WBGene00021452; WP:CE21725
Y39H10A.3 Y39H10A.3 P W All gene names: cup-10; mtm-9; Y39H10A.3; 5E227; CE26073; CE36959; NM_071637; NM_182367; WBGene00003479; WP:CE26073; WP:CE36959 WormBase description: mtm-9 encodes a myotubularin-related protein that affects phosphoinositide 3-phosphate localization and mutation blocks endocytosis by the coelomocytes of C. elegans; MTM-9 is believed to function as part of a complex with MTM-6A and it is predominantly localized to the coelomocyte cytoplasm, with some localization to the membrane.
Y44A6D.2 Y44A6D.2 P W All gene names: Y44A6D.2; 5V259; CE19160; WBGene00012853; WP:CE19160
Y47D3B.2 Y47D3B.2 P W All gene names: nlp-21; Y47D3B.2; 3M478; CE19175; CE24343; NM_067065; NM_067066; WBGene00003759; WP:CE19175; WP:CE24343 WormBase description: nlp-21 encodes nine predicted neuropeptide-like proteins; in C. elegans, nlp-21 is part of the GGARAF neuropeptide family that also contains nlp-9; nlp-21 is expressed in a variety of neurons, including AFD, five head neurons, the ventral nerve cord, one anterior pharyngeal neuron, and one tail neuron; nlp-21 expression is also detected in the embryo and the intestine; as loss of nlp-21 activity via large-scale RNAi screens does not result in any obvious abnormalities, the precise role of nlp-21-encoded peptides in development and/or behavior is not yet known.
Y51H7BR.3 Y51H7BR.3 P W All gene names: Y51H7BR.3; 2B825; CE25372; Q9N3J8_CAEEL; WBGene00021775; WP:CE25372
Y53F4B.12 Y53F4B.12 P W All gene names: Y53F4B.12; Y53F4B.O; 2P311; CE22401; WBGene00013159; WP:CE22401
Y54E2A.10 Y54E2A.10 P W All gene names: Y54E2A.10; 2P77; CE20309; WBGene00013195; WP:CE20309
Y57G11C.37 Y57G11C.37 P W All gene names: Y57G11C.37; 4P439; CE40485; WBGene00013326; WP:CE40485
Y67A10A.6 Y67A10A.6 P W All gene names: ssu-2; Y67A10A.6; 4P131; CE24567; NM_070342; WBGene00013455; WP:CE24567
Y67A10A.7 Y67A10A.7 P W All gene names: Y67A10A.7; 4P141; CE36248; WBGene00013456; WP:CE36248
ZC155.2 ZC155.2 P W All gene names: ZC155.2; 3G307; CE01432; WBGene00022530; WP:CE01432
ZC155.5 ZC155.5 P W All gene names: ZC155.5; 3G304; CE33007; CE33008; WBGene00022533; WP:CE33007; WP:CE33008
ZC21.2 ZC21.2 P W All gene names: trp-1; ZC21.2; 3J631; CE33009; CE39997; NM_066480; TRPL_CAEEL; WBGene00006614; WP:CE33009; WP:CE39997; strpc1 WormBase description: trp-1 encodes a predicted transmembrane protein with similarity to transient receptor potential (TRP) ion channels; a TRP-1::GFP reporter fusion is expressed in motor neurons, interneurons, vulval and intestinal muscles, and the BAG sensory neuron; as loss of trp-1 activity via deletion mutation or large-scale RNAi results in no obvious defects, the precise role of trp-1 in C. elegans development and/or behavior is not yet known.
ZC8.4 ZC8.4 P W All gene names: lfi-1; ZC8.4; CE31264; CE35814; CE38922; CE38923; NM_076446; NM_076447; Q23081_CAEEL; WBGene00022500; WP:CE31264; WP:CE35814; WP:CE38922; WP:CE38923; XF611 WormBase description: lfi-1 encodes a coiled-coil protein that is similar to the Parascaris univalens Mitotic Antigen, PUMA1; LFI-1 was initially identified in yeast two-hybrid screens for proteins that interact with the coiled-coil protein LIN-5, which is essential for proper spindle positioning and chromosome segregation; antibody staining reveals that, in embryos, LFI-1 is expressed in metaphase cells in a diffuse area surrounding the kinetochore microtubules and overlapping with LIN-5 localization; in interphase cells, LFI-1 localizes to the nucleus and remains in the nuclear region even after nuclear envelope breakdown; as loss of lfi-1 activity, or the combined activities of lfi-1 and a related gene, F35D11.11, by RNAi results in no obvious defects, the precise role of LFI-1 in development is not yet known.
ZC84.3 ZC84.3 P W All gene names: ZC84.3; 3K276; CE15022; WBGene00013847; WP:CE15022
ZC84.4 ZC84.4 P W All gene names: ZC84.4; 3K298; CE24711; WBGene00013848; WP:CE24711 WormBase description: ZC84.4 encodes a G protein-coupled receptor with acidic amino acids in the -3 position of its PDZ binding motif; ZC84.4 protein binds PDZ domain 10 of the multi-PDZ domain protein, MPZ-1, in GST pulldown experiments; by analogy with SER-1, the PDZ binding motif of ZC84.4 may enhance its signalling. WormBase CDS description: probable G protein coupled receptor
ZK1073.1 ZK1073.1 P W All gene names: ZK1073.1; CE03845; WBGene00014213; WP:CE03845; XQ738
ZK154.6 ZK154.6 P W All gene names: ZK154.6; CE28178; CE35816; WBGene00022668; WP:CE28178; WP:CE35816; XI410
ZK287.1 ZK287.1 P W All gene names: ZK287.1; 5K149; CE06610; WBGene00013962; WP:CE06610
ZK637.1 ZK637.1 P W All gene names: ZK637.1; 3J974; CE32291; WBGene00014021; WP:CE32291; YOU1; globin WormBase description: Sugar transporter
ZK849.2 ZK849.2 P W All gene names: ZK849.2; CE40678; CE40679; CE41095; O18302_CAEEL; WBGene00014101; WP:CE40678; WP:CE40679; WP:CE41095 WormBase description: PDZ domain (Also known as DHR or GLGF).