Stetina et al 2007, Interactome map of pan-neural , 53 genes

Gene list file name:Stetina2007_figure10
Type of gene identifier:Cosmid name
Description:A comparison to transcripts enriched in both embryonic pan-neural and larval pan-neural datasets revealed a single large interaction cluster  
Organism:Caenorhabditis elegans (nematode)
Gene list type:Experimental

Gene name             Source Gene ID          Annotation                                                  Date       Added by    

B0478.1 B0478.1, jnk-1 P W All gene names: jnk-1; sak-1; B0478.1; 4H727; CE27574; CE30123; JNK1_CAEEL; NM_171371; WBGene00002178; WP:CE27574; WP:CE30123 WormBase description: jnk-1 encodes a serine/threonine kinase that is the sole C. elegans member of the c-Jun N-terminal kinase (JNK) subgroup of mitogen-activated protein (MAP) kinases; JNK-1 exhibits kinase activity in vitro that is dependent upon activation by the JKK-1 MAPKK; a JNK-1::GFP translational fusion protein is expressed in nearly all neuronal cell bodies and processes, including the nerve ring, head and tail ganglions, and the dorsal and ventral nerve cords, at all stages of development.
B0547.1 B0547.1 P W All gene names: csn-5; B0547.1; 4G415; CE06722; CSN5_CAEEL; NM_068440; WBGene00000817; WP:CE06722 WormBase description: csn-5 encodes an ortholog of subunit 5 of the COP9 signalosome complex (CSN5), which in turn is a pan-eukaryotic multiprotein complex that positively regulates E3 ubiquitin ligases, physically interacts with SCF-type E3 ubiquitin ligases, and probably regulates protein degradation; CSN-5 (along with KGB-1 and ZYX-1) physically binds germline RNA helicases (GLH proteins), and csn-5(RNAi) results in sterile worms with small gonads and no oocytes, causing oogenesis to cease, but not affecting the initial assembly of P granules -- a defect essentially identical to that produced by RNAi with a combination of glh-1 and glh-4.
C12D8.1 C12D8.1 P W All gene names: C12D8.1; 5K718; CE05266; CE05267; CE39222; Q17936_CAEEL; WBGene00007534; WP:CE05266; WP:CE05267; WP:CE39222 WormBase description: C12D8.1 encodes two alternative proteins (through alternative splicing), that belong to an ancient family of single-stranded nucleic acid-binding proteins, and that are predicted to regulate gene expression through binding either mRNA or (locally) single-stranded DNA; they is most likely to specifically bind one or more discrete mRNAs and regulate their spatial localization or alternative splicing.
C18C4.10 C18C4.10, klc-2 P W All gene names: klc-2; C18C4.10; 5G58; CE27362; CE32802; CE32803; CE36917; KLC_CAEEL; WBGene00002215; WP:CE27362; WP:CE32802; WP:CE32803; WP:CE36917 WormBase description: klc-2 encodes a kinesin light chain and was identified as a protein that interacts with UNC-16 by the yeast two-hybrid system, this association suggests that KLC-2 may be involved in the regulation of synaptic vesicle localization by the UNC-16-JNK signaling complex.
C38D4.6 C38D4.6 P W All gene names: ceh-3; nob-2; pal-1; C38D4.6; 3F896; CE05383; CE27837; NM_065590; PAL1_CAEEL; WBGene00003912; WP:CE05383; WP:CE27837 WormBase description: pal-1 encodes a homeodomain protein that is the C. elegans Caudal ortholog; PAL-1 is required maternally and embryonically for cell fate specification and posterior patterning during embryogenesis; PAL-1 is also required postembryonically for fate specification of the posterior V6 neuroectoblast during male tail development; PAL-1 is expressed in posterior blastomeres beginning at the four-cell stage of embryogenesis and its expression continues during embryogenesis in posterior-derived tissues and cells undergoing movement or forming midline structures; pal-1 is subject to both transcriptional and translational regulation.
K07A9.2 K07A9.2, cmk-1 P W All gene names: Ce-CaM-KI; cmk-1; K07A9.2; 4C597; CE25046; NM_067738; Q9TXJ0_CAEEL; WBGene00000553; WP:CE25046 WormBase description: cmk-1 encodes a Ca+2/calmodulin-dependent protein kinase I (CaMK1); CMK-1 activity is required, cell autonomously and downstream of the cyclic nucleotide-gated channel TAX-4, for several aspects of AFD thermosensory neuron differentiation, including expression of the gcy-8 guanylyl cyclase and nhr-38 nuclear hormone receptor genes and morphology of the AFD sensory endings; cmk-1 activity is thus also required for normal thermosensory behavior; a cmk-1::gfp reporter is expressed in head sensory and interneurons as well as in the ventral nerve cord; expression is seen specifically in the neurons of the thermosensory circuit, AFD, AIY, and AIZ; CMK-1 localizes exclusively to the cytoplasm. WormBase CDS description: ser/thr protein kinase
F42A6.9 F42A6.9, elks-1 P W All gene names: elks-1; F42A6.9; 4E108; CE28392; NM_067928; O44490_CAEEL; WBGene00018330; WP:CE28392 WormBase description: elks-1 encodes the C. elegans homolog of the vertebrate ELKS (glutamine, leucine, lysine, and serine-rich) proteins; although loss of elks-1 activity results in no obvious developmental or behavioral abnormalities, the ELKS-1 C-terminus interacts with the PDZ domain of UNC-10/RIM in vitro, and in vivo each protein appears to play a nonessential role in localizing the other to the presynaptic active zone; in addition to the active zone, ELKS-1 also localizes to the pharyngeal basal lamina.
F01G4.1 F01G4.1, psa-4 P W All gene names: psa-4; F01G4.1; 4L895; CE05553; NM_069681; WBGene00004204; WP:CE05553 WormBase description: The psa-4 (phasmid socket absent) gene encodes an ortholog of SWI2/SNF2, a component of the SWI/SNF complex that is conserved from yeast to mammals and that is involved in chromatin remodeling; psa-4 is probably required during mitosis of the T cells for asymmetric cell division. WormBase CDS description: SNF2alpha like
F13B9.5 F13B9.5, ksr-1 P W All gene names: ksr-1; sar-2; sur-3; F13B9.5; CE25854; NM_076995; WBGene00002239; WP:CE25854; XI901
F14F3.1 F14F3.1, vab-3 P W All gene names: lin-20; mab-18; pax-6; vab-3; F14F3.1; CE24899; CE28216; CE28217; Q17359_CAEEL; WBGene00006870; WP:CE24899; WP:CE28216; WP:CE28217; XL137 WormBase description: vab-3 encodes a homeodomain protein that is the C. elegans Pax-6 orthologue; during development, vab-3 activity is required for proper patterning of anterior (head) hypodermal cells; vab-3 effects head development, in part, through positively regulating transcription of ceh-32, a Six/sine oculis class homeobox gene coexpressed with vab-3 in head hypodermis.
F35C8.3 F35C8.3, jkk-1 P W All gene names: jkk-1; sek-2; F35C8.3; CE24941; NM_076512; Q9UAH1_CAEEL; WBGene00002177; WP:CE24941; XF989 WormBase description: jkk-1 encodes a member of the MAP kinase kinase superfamily that affects synaptic vesicle localization and is required in type-D motor neurons for normal locomotion; can function in the Hog1 MAP kinase pathway I in yeast as an activator of JNK and is expressed in most neurons
F42A6.9 F42A6.9, elks-1 P W All gene names: elks-1; F42A6.9; 4E108; CE28392; NM_067928; O44490_CAEEL; WBGene00018330; WP:CE28392 WormBase description: elks-1 encodes the C. elegans homolog of the vertebrate ELKS (glutamine, leucine, lysine, and serine-rich) proteins; although loss of elks-1 activity results in no obvious developmental or behavioral abnormalities, the ELKS-1 C-terminus interacts with the PDZ domain of UNC-10/RIM in vitro, and in vivo each protein appears to play a nonessential role in localizing the other to the presynaptic active zone; in addition to the active zone, ELKS-1 also localizes to the pharyngeal basal lamina.
F42G10.2 F42G10.2, mkk-4 P W All gene names: mkk-4; F42G10.2; CE10328; NM_077281; WBGene00003368; WP:CE10328; XK651; YR62_CAEEL WormBase description: mkk-4 encodes a MAP (mitogen-activated protein) kinase kinase that is a member of the MKK4 family of MAPKK's; MKK-4 activity is required in presynaptic neurons, in a dose-dependent manner, for normal presynaptic development and morphology; in regulating presynaptic organization, MKK-4 acts upstream of PMK-3/MAPK and downstream of DLK-1/MAPKKK, whose levels are negatively regulated by the RPM-1 ubiquitin ligase; a functional MKK-4::GFP fusion protein is expressed in the cytoplasm of many neurons as well as in other cell types, including the pharyngeal muscles. WormBase CDS description: serine/threonine kinase
F43C1.2 F43C1.2, mpk-1 P W All gene names: mpk-1; sur-1; F43C1.2; 3F308; CE01583; CE24971; SUR1_CAEEL; WBGene00003401; WP:CE01583; WP:CE24971 WormBase description: mpk-1 encodes a mitogen-activated protein (MAP) kinase that acts in the vulval precursor cells to affect LET-60(Ras)-mediated induction of vulval cell fates, and also affects larval viability, morphology of the male spicules, and acts in combination with mek-2 to permit germ cell exit from the pachytene stage of first meiotic prophase; both LIN-1 and LIN-31 act genetically downstream of mpk-1 with respect to vulval induction, and LIN-1 and LIN-31 are substrates for MPK-1 in vitro. WormBase CDS description: serine/threonine kinase (CDC2/CDC28 subfamily)
F43G6.8 F43G6.8 P W All gene names: F43G6.8; 2M102; CE20789; Q20369_CAEEL; WBGene00009660; WP:CE20789 WormBase description: Zinc finger, C3HC4 type (RING finger)
F44G3.9 F44G3.9 P W All gene names: nhr-111; F44G3.9; 5Q604; CE35538; NH111_CAEEL; NM_074659; WBGene00003701; WP:CE35538 WormBase description: nhr-111 encodes a member of the nuclear receptor superfamily; by homology, NHR-111 is predicted to function as a ligand-dependent transcriptional regulator, but as loss of nhr-111 activity via large-scale RNAi screens does not result in any abnormalities, the precise role of NHR-111 in C. elegans development and/or behavior is not yet known; an nhr-111 reporter construct is expressed in embryos and early larvae in a pair of neurons in the ventral ganglion of the head and in two cells that may be the somatic gonad precursors. WormBase CDS description: Zinc finger, C4 type (two domains)
F46G11.1 F46G11.1 P W All gene names: F46G11.1; CE37646; WBGene00018514; WP:CE37646; XG415 WormBase description: F46G11.1 is orthologous to the human gene TRUNCATED PUTATIVE T7-LIKE MITOCHONDRIAL DNA HELICASE (C10orf2; OMIM:606075), which when mutated leads to disease.
F49H12.3 F49H12.3 P W All gene names: F49H12.3; CE20837; Q9N5S5_CAEEL; WBGene00018654; WP:CE20837; XC703
F53G12.10 F53G12.10, rpl-7 P W All gene names: rpl-7; F53G12.10; 1A583; CE11024; NM_058275; RL7_CAEEL; WBGene00004418; WP:CE11024 WormBase description: rpl-7 encodes a large ribosomal subunit L7 protein required in mass RNAi assays for embryonic viability and normally rapid growth. WormBase CDS description: ribosomal protein
F59A6.1 F59A6.1, nsy-1 P W All gene names: ask-1; esp-8; nsy-1; F59A6.1; 2F319; CE33405; NM_062524; Q21029_CAEEL; WBGene00003822; WP:CE33405 WormBase description: nsy-1 encodes a MAP kinase kinase kinase homolog that affects chemotaxis, egg laying, and pathogen response; NSY-1 activity is activated by the calmodulin kinase UNC-43, and is required for lateral signalling that leads to asymmetric olfactory neuron fates; interacts with SEK-1, and is expressed in the intestine, hypodermis, rectal gland cells, and neurons. WormBase CDS description: Protein kinase
W07B3.2 W07B3.2, gei-4 P W All gene names: gei-4; W07B3.2; 3A962; CE17290; CE17291; CE32743; CE34603; CE34604; CE37419; NM_064787; NM_064788; NM_064789; NM_181925; Q9TZ38_CAEEL; WBGene00001561; WP:CE17290; WP:CE17291; WP:CE32743; WP:CE34603; WP:CE34604; WP:CE37419 WormBase description: gei-4 encodes a protein with a coiled-coil domain (predicted to mediate protein-protein interactions), an internal repeat of 69 residues (covering residues 134-202, 203-265, and 266-328 of W07B3.2a), and a glutamine/asparagine-rich domain; GEI-4 is paralogous to Y50D7A.8 and Y59C2A.3, physically interacts with GEX-2, and is required for embryonic viability, fertility, and vulval morphogenesis; GEI-4 is claimed to have weak homology to trichohyalin, a mammalian intermediate filament interacting protein; the similarity of the mutant phenotypes of gei-4, gex-2 and gex-3 and their interaction sugggest that the GEX-2/GEX-3/GEI-4 protein complex is essential for the regulation of intermediate filaments during rearrangement of the cytoskeleton that occurs in embryogenesis; GFI-2, an ankyrin-repeat protein associates with GEI-4 and exhibits a similar mutant phenotype, suggesting that gfi-2 is also involved in intermediate filament dynamics.
H06I04.1 H06I04.1 P W All gene names: H06I04.1; 3E189; CE29971; CE31020; CE31021; Q9N5N7_CAEEL; WBGene00019167; WP:CE29971; WP:CE31020; WP:CE31021
F35C8.3 F35C8.3, jkk-1 P W All gene names: jkk-1; sek-2; F35C8.3; CE24941; NM_076512; Q9UAH1_CAEEL; WBGene00002177; WP:CE24941; XF989 WormBase description: jkk-1 encodes a member of the MAP kinase kinase superfamily that affects synaptic vesicle localization and is required in type-D motor neurons for normal locomotion; can function in the Hog1 MAP kinase pathway I in yeast as an activator of JNK and is expressed in most neurons
B0478.1 B0478.1, jnk-1 P W All gene names: jnk-1; sak-1; B0478.1; 4H727; CE27574; CE30123; JNK1_CAEEL; NM_171371; WBGene00002178; WP:CE27574; WP:CE30123 WormBase description: jnk-1 encodes a serine/threonine kinase that is the sole C. elegans member of the c-Jun N-terminal kinase (JNK) subgroup of mitogen-activated protein (MAP) kinases; JNK-1 exhibits kinase activity in vitro that is dependent upon activation by the JKK-1 MAPKK; a JNK-1::GFP translational fusion protein is expressed in nearly all neuronal cell bodies and processes, including the nerve ring, head and tail ganglions, and the dorsal and ventral nerve cords, at all stages of development.
K07A9.2 K07A9.2, cmk-1 P W All gene names: Ce-CaM-KI; cmk-1; K07A9.2; 4C597; CE25046; NM_067738; Q9TXJ0_CAEEL; WBGene00000553; WP:CE25046 WormBase description: cmk-1 encodes a Ca+2/calmodulin-dependent protein kinase I (CaMK1); CMK-1 activity is required, cell autonomously and downstream of the cyclic nucleotide-gated channel TAX-4, for several aspects of AFD thermosensory neuron differentiation, including expression of the gcy-8 guanylyl cyclase and nhr-38 nuclear hormone receptor genes and morphology of the AFD sensory endings; cmk-1 activity is thus also required for normal thermosensory behavior; a cmk-1::gfp reporter is expressed in head sensory and interneurons as well as in the ventral nerve cord; expression is seen specifically in the neurons of the thermosensory circuit, AFD, AIY, and AIZ; CMK-1 localizes exclusively to the cytoplasm. WormBase CDS description: ser/thr protein kinase
K11E8.1 K11E8.1, unc-43 P W All gene names: dec-8; unc-43; K11E8.1; 4L90; CE28051; CE28052; CE28053; CE28054; CE28055; CE28056; CE28057; CE28058; CE28059; CE28060; CE28061; CE35590; CE40979; O62305_CAEEL; Q21431_CAEEL; WBGene00006779; WP:CE28051; WP:CE28052; WP:CE28053; WP:CE28054; WP:CE28055; WP:CE28056; WP:CE28057; WP:CE28058; WP:CE28059; WP:CE28060; WP:CE28061; WP:CE35590; WP:CE40979 WormBase description: unc-43(gf) mutants (in which unc-43 is overexpressed) suppress the excess motoneuron branching, and thus the uncoordinated phenotype, induced by an unc-6deltaC transgene. WormBase CDS description: Ca2+/calmodulin-dependent protein kinase
C18C4.10 C18C4.10, klc-2 P W All gene names: klc-2; C18C4.10; 5G58; CE27362; CE32802; CE32803; CE36917; KLC_CAEEL; WBGene00002215; WP:CE27362; WP:CE32802; WP:CE32803; WP:CE36917 WormBase description: klc-2 encodes a kinesin light chain and was identified as a protein that interacts with UNC-16 by the yeast two-hybrid system, this association suggests that KLC-2 may be involved in the regulation of synaptic vesicle localization by the UNC-16-JNK signaling complex.
F13B9.5 F13B9.5, ksr-1 P W All gene names: ksr-1; sar-2; sur-3; F13B9.5; CE25854; NM_076995; WBGene00002239; WP:CE25854; XI901
ZC8.4 ZC8.4, lfi-1 P W All gene names: lfi-1; ZC8.4; CE31264; CE35814; CE38922; CE38923; NM_076446; NM_076447; Q23081_CAEEL; WBGene00022500; WP:CE31264; WP:CE35814; WP:CE38922; WP:CE38923; XF611 WormBase description: lfi-1 encodes a coiled-coil protein that is similar to the Parascaris univalens Mitotic Antigen, PUMA1; LFI-1 was initially identified in yeast two-hybrid screens for proteins that interact with the coiled-coil protein LIN-5, which is essential for proper spindle positioning and chromosome segregation; antibody staining reveals that, in embryos, LFI-1 is expressed in metaphase cells in a diffuse area surrounding the kinetochore microtubules and overlapping with LIN-5 localization; in interphase cells, LFI-1 localizes to the nucleus and remains in the nuclear region even after nuclear envelope breakdown; as loss of lfi-1 activity, or the combined activities of lfi-1 and a related gene, F35D11.11, by RNAi results in no obvious defects, the precise role of LFI-1 in development is not yet known.
F42G10.2 F42G10.2, mkk-4 P W All gene names: mkk-4; F42G10.2; CE10328; NM_077281; WBGene00003368; WP:CE10328; XK651; YR62_CAEEL WormBase description: mkk-4 encodes a MAP (mitogen-activated protein) kinase kinase that is a member of the MKK4 family of MAPKK's; MKK-4 activity is required in presynaptic neurons, in a dose-dependent manner, for normal presynaptic development and morphology; in regulating presynaptic organization, MKK-4 acts upstream of PMK-3/MAPK and downstream of DLK-1/MAPKKK, whose levels are negatively regulated by the RPM-1 ubiquitin ligase; a functional MKK-4::GFP fusion protein is expressed in the cytoplasm of many neurons as well as in other cell types, including the pharyngeal muscles. WormBase CDS description: serine/threonine kinase
F43C1.2 F43C1.2, mpk-1 P W All gene names: mpk-1; sur-1; F43C1.2; 3F308; CE01583; CE24971; SUR1_CAEEL; WBGene00003401; WP:CE01583; WP:CE24971 WormBase description: mpk-1 encodes a mitogen-activated protein (MAP) kinase that acts in the vulval precursor cells to affect LET-60(Ras)-mediated induction of vulval cell fates, and also affects larval viability, morphology of the male spicules, and acts in combination with mek-2 to permit germ cell exit from the pachytene stage of first meiotic prophase; both LIN-1 and LIN-31 act genetically downstream of mpk-1 with respect to vulval induction, and LIN-1 and LIN-31 are substrates for MPK-1 in vitro. WormBase CDS description: serine/threonine kinase (CDC2/CDC28 subfamily)
F59A6.1 F59A6.1, nsy-1 P W All gene names: ask-1; esp-8; nsy-1; F59A6.1; 2F319; CE33405; NM_062524; Q21029_CAEEL; WBGene00003822; WP:CE33405 WormBase description: nsy-1 encodes a MAP kinase kinase kinase homolog that affects chemotaxis, egg laying, and pathogen response; NSY-1 activity is activated by the calmodulin kinase UNC-43, and is required for lateral signalling that leads to asymmetric olfactory neuron fates; interacts with SEK-1, and is expressed in the intestine, hypodermis, rectal gland cells, and neurons. WormBase CDS description: Protein kinase
F39D8.2 psa-3 P W
F01G4.1 F01G4.1, psa-4 P W All gene names: psa-4; F01G4.1; 4L895; CE05553; NM_069681; WBGene00004204; WP:CE05553 WormBase description: The psa-4 (phasmid socket absent) gene encodes an ortholog of SWI2/SNF2, a component of the SWI/SNF complex that is conserved from yeast to mammals and that is involved in chromatin remodeling; psa-4 is probably required during mitosis of the T cells for asymmetric cell division. WormBase CDS description: SNF2alpha like
R03G5.2 R03G5.2, sek-1 P W All gene names: esp-2; sek-1; R03G5.2; CE31210; NM_076921; Q95YI9_CAEEL; WBGene00004758; WP:CE31210; XI439 WormBase description: SEK-1 has MAPKK activity and belongs to the MAPKK family; SEK-1 can activate both JNK-1 and PMK-1 in the yeast Hog pathway. WormBase CDS description: SER/THR-protein kinase
R07E5.3 R07E5.3 P W All gene names: R07E5.3; 3F495; CE01045; Q21831_CAEEL; WBGene00011111; WP:CE01045 WormBase description: The R07E5.3 gene encodes a homolog of SNF5/Ini1, a component of the SWI/SNF complex that is conserved from yeast to mammals and that is involved in chromatin remodeling; R07E5.3 may be involved in asymmetric cell division of the T cells. WormBase CDS description: Snf5 (yeast)
F53G12.10 F53G12.10, rpl-7 P W All gene names: rpl-7; F53G12.10; 1A583; CE11024; NM_058275; RL7_CAEEL; WBGene00004418; WP:CE11024 WormBase description: rpl-7 encodes a large ribosomal subunit L7 protein required in mass RNAi assays for embryonic viability and normally rapid growth. WormBase CDS description: ribosomal protein
R03G5.2 R03G5.2, sek-1 P W All gene names: esp-2; sek-1; R03G5.2; CE31210; NM_076921; Q95YI9_CAEEL; WBGene00004758; WP:CE31210; XI439 WormBase description: SEK-1 has MAPKK activity and belongs to the MAPKK family; SEK-1 can activate both JNK-1 and PMK-1 in the yeast Hog pathway. WormBase CDS description: SER/THR-protein kinase
Y46G5A.30 snf-5 P W
T05C12.6 T05C12.6 P W All gene names: mig-5; T05C12.6; 2I474; CE02318; CE25100; CE28076; Q22227_CAEEL; WBGene00003241; WP:CE02318; WP:CE25100; WP:CE28076 WormBase description: mig-5 encodes one of three C. elegans Dishevelled homologs; as part of both canonical and non-canonical Wnt signaling pathways, mig-5 activity is required maternally and embryonically for cell migration, cell fate specification, and proper spindle orientation in the early embryo; cells affected by mig-5 mutations include the distal tip cells (DTCs), the QL neuroblast descendants (QL.d), the vulval precursor cells, and the P12 ectoblast; in the early embryo, MIG-5 functions downstream of MOM-2/Wnt and MOM-1/Porc, and redundantly with two other Dishevelled homologs, DSH-1 and DSH-2, in a non-canonical Wnt pathway that specifies the endoderm cell fate and regulates mitotic spindle orientation in the EMS and ABar blastomeres; in posteriorly directed QL.d migrations, MIG-5 functions downstream of EGL-20/Wnt and upstream of PRY-1/Axin in a canonical Wnt pathway to positively regulate Wnt signaling and effect MAB-5 expression in QL.d; a mig-5::GFP fusion is reportedly expressed in many cells in the embryo, migrating DTCs, P cells, and the nerve ring. WormBase CDS description: presynaptic density protein (PSD-95) repeat-like domain
T17H7.4 T17H7.4 P W All gene names: gei-16; T17H7.4; 3B346; CE28670; CE28671; CE28672; CE31612; CE31613; CE31614; CE31615; CE31616; CE31617; CE31618; CE33939; CE35016; NM_064843; NM_064844; NM_064845; NM_064846; NM_064847; NM_171067; NM_171068; NM_171069; NM_171070; NM_171071; NM_171859; Q22534_CAEEL; WBGene00001573; WP:CE28670; WP:CE28671; WP:CE28672; WP:CE31612; WP:CE31613; WP:CE31614; WP:CE31615; WP:CE31616; WP:CE31617; WP:CE31618; WP:CE33939; WP:CE35016 WormBase description: gei-16 can encode a protein with similarity to the B20 antigen of the parasitic nematode Onchocerca volvulus; GEI-16 is required for ventral enclosure and elongation during embryonic development, larval development, and normal rates of postembryonic growth; GEI-16 interacts with GEX-3, a homolog of mammalian protein ligands of the small GTPase Rac1 that is also essential for embryonic morphogenesis.
T21H3.3 T21H3.3 P W All gene names: cmd-1; T21H3.3; 5B635; CALM_CAEEL; CE13902; NM_070985; WBGene00000552; WP:CE13902 WormBase description: cmd-1 encodes a putative homolog of calmodulin 1 that affects growth rate and fertility. WormBase CDS description: calmodulin
T22H2.5 T22H2.5 P W All gene names: plsc-2; scrm-1; T22H2.5; 1M282; CE36204; CE36205; O45799_CAEEL; WBGene00011935; WP:CE36204; WP:CE36205 WormBase description: T22H2.5 encodes a homolog of human scramblase (PLSCR1; OMIM:604170), which is activated by a rise of intracellular calcium, and which promotes the exposure of phosphatidylserine on the surface of cells undergoing activation, injury, or apoptosis; closely related paralogs of T22H2.5 include C04E12.7 and ZK1053.5.
ZK1098.10 ZK1098.10, unc-16 P W All gene names: egl-39; unc-16; ZK1098.10; 3K645; CE00363; CE31846; JIP_CAEEL; NM_171221; WBGene00006755; WP:CE00363; WP:CE31846 WormBase description: unc-16 encodes a homolog of murine JIP3/JSAP and Drosophila SUNDAY DRIVER that is involved in vesicle transport, and that affects egg laying, locomotion, and defecation and physically interacts with JNK and JNK kinases; UNC-16 is expressed in neurons of the ventral cord, retrovesicular and preanal ganglia, the nerve ring, intestinal cells, seam and hypodermal cells, body wall and head muscle, and pharynx.
K11E8.1 K11E8.1, unc-43 P W All gene names: dec-8; unc-43; K11E8.1; 4L90; CE28051; CE28052; CE28053; CE28054; CE28055; CE28056; CE28057; CE28058; CE28059; CE28060; CE28061; CE35590; CE40979; O62305_CAEEL; Q21431_CAEEL; WBGene00006779; WP:CE28051; WP:CE28052; WP:CE28053; WP:CE28054; WP:CE28055; WP:CE28056; WP:CE28057; WP:CE28058; WP:CE28059; WP:CE28060; WP:CE28061; WP:CE35590; WP:CE40979 WormBase description: unc-43(gf) mutants (in which unc-43 is overexpressed) suppress the excess motoneuron branching, and thus the uncoordinated phenotype, induced by an unc-6deltaC transgene. WormBase CDS description: Ca2+/calmodulin-dependent protein kinase
F14F3.1 F14F3.1, vab-3 P W All gene names: lin-20; mab-18; pax-6; vab-3; F14F3.1; CE24899; CE28216; CE28217; Q17359_CAEEL; WBGene00006870; WP:CE24899; WP:CE28216; WP:CE28217; XL137 WormBase description: vab-3 encodes a homeodomain protein that is the C. elegans Pax-6 orthologue; during development, vab-3 activity is required for proper patterning of anterior (head) hypodermal cells; vab-3 effects head development, in part, through positively regulating transcription of ceh-32, a Six/sine oculis class homeobox gene coexpressed with vab-3 in head hypodermis.
W07B3.2 W07B3.2, gei-4 P W All gene names: gei-4; W07B3.2; 3A962; CE17290; CE17291; CE32743; CE34603; CE34604; CE37419; NM_064787; NM_064788; NM_064789; NM_181925; Q9TZ38_CAEEL; WBGene00001561; WP:CE17290; WP:CE17291; WP:CE32743; WP:CE34603; WP:CE34604; WP:CE37419 WormBase description: gei-4 encodes a protein with a coiled-coil domain (predicted to mediate protein-protein interactions), an internal repeat of 69 residues (covering residues 134-202, 203-265, and 266-328 of W07B3.2a), and a glutamine/asparagine-rich domain; GEI-4 is paralogous to Y50D7A.8 and Y59C2A.3, physically interacts with GEX-2, and is required for embryonic viability, fertility, and vulval morphogenesis; GEI-4 is claimed to have weak homology to trichohyalin, a mammalian intermediate filament interacting protein; the similarity of the mutant phenotypes of gei-4, gex-2 and gex-3 and their interaction sugggest that the GEX-2/GEX-3/GEI-4 protein complex is essential for the regulation of intermediate filaments during rearrangement of the cytoskeleton that occurs in embryogenesis; GFI-2, an ankyrin-repeat protein associates with GEI-4 and exhibits a similar mutant phenotype, suggesting that gfi-2 is also involved in intermediate filament dynamics.
Y113G7B.23 Y113G7B.23 P W All gene names: psa-1; Y113G7B.23; 5U710; CE25208; NM_075505; Q9U2W6_CAEEL; WBGene00004203; WP:CE25208 WormBase description: psa-1 encodes an ortholog of SWI3, a component of the SWI/SNF complex that is conserved from yeast to mammals and that is involved in chromatin remodeling; psa-1 is probably required during mitosis of the T cells for asymmetric cell division, and in addition, is required for embryonic and larval development, as well as normal levels of fertility; psa-1 exhibits strong genetic interactions with lin-35/Rb, as psa-1 larval lethality and sterility at 20 degrees C are greatly enhanced in lin-35;psa-1 double mutants. WormBase CDS description: SWI/SNF protein
Y51H4A.17 Y51H4A.17 P W All gene names: sta-1; Y51H4A.17; 4R613; CE35668; CE41061; STAT1_CAEEL; WBGene00013111; WP:CE35668; WP:CE41061 WormBase description: sta-1 encodes the C. elegans STAT orthologue; from N- to C-terminus, STA-1 contains conserved coiled-coil, DNA-binding, and SH2 domains, but apparently lacks a conserved amino-terminal oligomerization domain found in other STAT family members; sta-1 activity is required for repressing dauer formation at high temperatures and genetic analyses indicate that STA-1 acts redundantly with some members of the DAF-7/TGF-beta signaling pathway to repress dauer formation, particularly at low temperatures; tyrosine-phosphorylated STA-1 is able to bind a high affinity mammalian STAT binding sequence, and the STA-1 C-terminus can function as a transcriptional activation domain; sta-1 is widely expressed during most life stages, including the dauer stage, and is found in the pharynx, intestine, body wall muscles, and in neurons; STA-1 localizes to both the cytoplasm and the nucleus, with expression in the latter found particularly in some amphid neurons; in some neurons, STA-1 expression appears to be negatively regulated by DAF-7/TGF-beta signaling.
Y54E10BL.6 Y54E10BL.6 P W All gene names: glv-1; let-537; mek-2; Y54E10BL.6; Y54E10B_152.C; 1D574; CE25437; NM_058686; WBGene00003186; WP:CE25437 WormBase description: protein kinase
ZC8.4 ZC8.4, lfi-1 P W All gene names: lfi-1; ZC8.4; CE31264; CE35814; CE38922; CE38923; NM_076446; NM_076447; Q23081_CAEEL; WBGene00022500; WP:CE31264; WP:CE35814; WP:CE38922; WP:CE38923; XF611 WormBase description: lfi-1 encodes a coiled-coil protein that is similar to the Parascaris univalens Mitotic Antigen, PUMA1; LFI-1 was initially identified in yeast two-hybrid screens for proteins that interact with the coiled-coil protein LIN-5, which is essential for proper spindle positioning and chromosome segregation; antibody staining reveals that, in embryos, LFI-1 is expressed in metaphase cells in a diffuse area surrounding the kinetochore microtubules and overlapping with LIN-5 localization; in interphase cells, LFI-1 localizes to the nucleus and remains in the nuclear region even after nuclear envelope breakdown; as loss of lfi-1 activity, or the combined activities of lfi-1 and a related gene, F35D11.11, by RNAi results in no obvious defects, the precise role of LFI-1 in development is not yet known.
ZK1098.10 ZK1098.10, unc-16 P W All gene names: egl-39; unc-16; ZK1098.10; 3K645; CE00363; CE31846; JIP_CAEEL; NM_171221; WBGene00006755; WP:CE00363; WP:CE31846 WormBase description: unc-16 encodes a homolog of murine JIP3/JSAP and Drosophila SUNDAY DRIVER that is involved in vesicle transport, and that affects egg laying, locomotion, and defecation and physically interacts with JNK and JNK kinases; UNC-16 is expressed in neurons of the ventral cord, retrovesicular and preanal ganglia, the nerve ring, intestinal cells, seam and hypodermal cells, body wall and head muscle, and pharynx.
ZK849.2 ZK849.2 P W All gene names: ZK849.2; CE40678; CE40679; CE41095; O18302_CAEEL; WBGene00014101; WP:CE40678; WP:CE40679; WP:CE41095 WormBase description: PDZ domain (Also known as DHR or GLGF).