|Gene list file name:||Blumenthal2002_supp1|
|Type of gene identifier:||Cosmid name|
|Description:||genes confirmed to be transpliced to SL2/SL12 from cDNA clone analysis, from the worm transcriptome project, lead by Y.Kohara.|
|Organism:||Caenorhabditis elegans (nematode)|
|Gene list type:||Experimental|
Gene name Source Gene ID Annotation Date Added by
B0001.3 B0001.3 P W All gene names: B0001.3; 4M908; CE29523; WBGene00007088; WP:CE29523
B0001.5 B0001.5 P W All gene names: B0001.5; CE29524; WBGene00007090; WP:CE29524
B0024.10 B0024.10 P W All gene names: B0024.10; 5K796; CE05154; WBGene00007100; WP:CE05154
B0025.1 B0025.1 P W All gene names: let-512; vps-34; B0025.1; 1G609; CE24759; CE24760; CE37691; CE37738; CE37739; NM_059340; WBGene00006932; WP:CE24759; WP:CE24760; WP:CE37691; WP:CE37738; WP:CE37739 WormBase description: The vps-34 gene encodes an ortholog of the phosphoinositide 3-kinase VPS34 in S. cerevisiae, a protein that regulates multiple steps in endocytosis, and that is required for growth at normal rates during development.
B0025.2 B0025.2 P W All gene names: csn-2; B0025.2; 1G601; CE27562; CSN2_CAEEL; NM_059339; WBGene00000814; WP:CE27562 WormBase description: csn-2 encodes a homolog of COP9 signalosome complex subunit 2 that affects embryonic viability and growth rate.
B0035.11 B0035.11 P W All gene names: B0035.11; 4M94; CE05166; WBGene00007110; WP:CE05166 WormBase description: Yeast LEO1 protein like
B0035.16 B0035.16 P W All gene names: B0035.16; 4M60; CE26926; WBGene00007114; WP:CE26926 WormBase description: Haemophilus hypothetical protein HI1074 like
B0035.2 B0035.2 P W All gene names: dnj-2; B0035.2; 4M78; CE05160; NM_069725; WBGene00001020; WP:CE05160 WormBase description: This gene encodes a protein containing a DnaJ ('J') domain. WormBase CDS description: DNAJ protein like
B0035.5 B0035.5 P W All gene names: B0035.5; 4M83; CE05163; WBGene00007108; WP:CE05163 WormBase description: B0035.5 is orthologous to the human gene GLUCOSE-6-PHOSPHATE DEHYDROGENASE (G6PD; OMIM:305900), which when mutated leads to disease. WormBase CDS description: glucose-6-phosphate-1-dehydrogenase
B0205.3 B0205.3 P W All gene names: mcb-1; rpn-10; B0205.3; 1L308; CE26355; NM_060408; WBGene00004466; WP:CE26355 WormBase description: rpn-10 encodes a protein that contains two ubiquitin interaction motifs and is a member of the von Willebrand factor, type A superfamily similar to the mouse 26S proteasome non-ATP regulatory subunit 4.
B0205.7 B0205.7 P W All gene names: kin-3; B0205.7; 1L311; CE17321; NM_060410; WBGene00002191; WP:CE17321 WormBase description: kin-3 encodes an ortholog of the catalytic subunit of casein kinase II alpha, which in Drosophila and mammals is required for normal circadian rhythms, and which directly phosphorylates the Drosophila PERIOD protein (which itself regulates circadian rhythms); by analogy, KIN-3 might be expected to help regulate heterochronic functions dependent on such proteins as LIN-42. WormBase CDS description: casein kinase
B0218.2 B0218.2 P W All gene names: B0218.2; 4I919; CE06685; WBGene00015048; WP:CE06685 WormBase description: amidase
B0334.3 B0334.3 P W All gene names: B0334.3; 2L780; CE02935; CE19658; WBGene00007143; WP:CE02935; WP:CE19658 WormBase description: Thiamine pyrophosphate enzymes
B0334.5 B0334.5 P W All gene names: B0334.5; 2L789; CE30122; WBGene00007145; WP:CE30122 WormBase description: phytoene synthase precursor
B0336.10 B0336.10 P W All gene names: rpl-23; B0336.10; 3G794; CE00778; NM_065830; WBGene00004435; WP:CE00778 WormBase description: rpl-23 encodes a large ribosomal subunit L23 protein.
B0336.2 B0336.2 P W All gene names: arf-1.2; arf-1; B0336.2; 3G805; ARF/1; ARF12_CAEEL; CE00696; NM_065834; WBGene00000182; WP:CE00696 WormBase description: arf-1 encodes an ADP-ribosylation factor homolog required in vivo for embryonic development, fertility, locomotion, vulval development, and cuticular synthesis; ARF proteins are N-myristoylated GTPases that regulate membrane traffic and the actin cytoskeleton, and that activate both phospholipase D1 (PLD1) and phosphatidylinositol 4-phosphate 5-kinase. WormBase CDS description: ARF
B0336.7 B0336.7 P W All gene names: B0336.7; 3G784; CE29546; CE37741; Q10930_CAEEL; WBGene00015147; WP:CE29546; WP:CE37741
B0432.3 B0432.3 P W All gene names: B0432.3; 2A579; CE07741; WBGene00015185; WP:CE07741
B0432.9 B0432.9 P W All gene names: B0432.9; 2A570; CE34245; WBGene00015190; WP:CE34245 WormBase description: zinc finger protein
B0464.1 B0464.1 P W All gene names: drs-1; B0464.1; 3K580; CE00015; NM_066688; WBGene00001094; WP:CE00015 WormBase description: drs-1 encodes a putative aspartyl(D) tRNA synthetase WormBase CDS description: Aspartyl-tRNA synthetase
B0464.8 B0464.8 P W All gene names: tag-342; B0464.8; 3K559; CE36465; Q9XVX8_CAEEL; WBGene00007187; WP:CE36465
B0495.5 B0495.5 P W All gene names: B0495.5; 2H986; CE29948; WBGene00015204; WP:CE29948; YP65_CAEEL
B0495.7 B0495.7 P W All gene names: B0495.7; 2H992; CE29550; WBGene00015206; WP:CE29550
B0495.8 B0495.8 P W All gene names: B0495.8; 2H996; CE01766; CE29949; WBGene00015207; WP:CE01766; WP:CE29949
B0511.7 B0511.7 P W All gene names: B0511.7; 1L208; CE34246; WBGene00015233; WP:CE34246
B0511.8 B0511.8 P W All gene names: tag-264; B0511.8; 1L214; CE28880; WBGene00015234; WBGene00044321; WP:CE28880
B0511.9 B0511.9 P W All gene names: cdc-26; mat-4; tag-265; B0511.9; 1L216; CE17348; CE26854; Q8T7Y7_CAEEL; WBGene00015235; WP:CE17348; WP:CE26854
B0546.2 B0546.2 P W All gene names: B0546.2; 4E138; CE40597; WBGene00015249; WP:CE40597
B0564.7 B0564.7 P W All gene names: B0564.7; 4N867; CE36971; WBGene00007207; WP:CE36971 WormBase description: Zinc finger, C3HC4 type (RING finger)
C01A2.3 C01A2.3 P W All gene names: C01A2.3; 1N981; CE38582; WBGene00007215; WP:CE38582 WormBase description: cytochrome oxidase biogenesis protein like
C01F6.8 C01F6.8 P W All gene names: icl-1; C01F6.8; 4J860; CE17360; CE30069; ICln; WBGene00002046; WP:CE17360; WP:CE30069 WormBase description: The icl-1 gene encodes, through alternative splicing, two alternative forms (ICL-1A, or 'IClnN1', and ICL-1B, or 'IClnN2'), with distinct electrophysiological properties, of an anion channel homolog. WormBase CDS description: nucleotide-sensitive chloride ion channel
C01G8.2 C01G8.2 P W All gene names: cln-3.2; C01G8.2; 1F844; CE07802; NM_059155; WBGene00000540; WP:CE07802 WormBase description: cln-3.2 encodes a predicted transmembrane protein that comprises one of three C. elegans homologs of human CLN3 (OMIM:607042, mutations are associated with Batten disease (also known as juvenile neuronal ceroid lipofuscinosis), a recessively inherited childhood neurodegenerative lysosomal storage disease); loss of cln-3.2 activity via large-scale RNAi screens has been reported to result in either no defects or in embryonic lethality.
C01G8.4 C01G8.4 P W All gene names: dnj-4; C01G8.4; 1F850; CE26905; NM_059157; WBGene00001022; WP:CE26905 WormBase description: This gene encodes a protein containing a DnaJ ('J') domain.
C01G8.5 C01G8.5 P W All gene names: erm-1; C01G8.5; 1F852; CE07805; CE07806; NM_059158; NM_059159; P91016_CAEEL; WBGene00001333; WP:CE07805; WP:CE07806 WormBase description: The erm-1 gene encodes an ortholog of the ERM family of cytoskeletal linkers with approximately equal similarity to ezrin, radixin and moesin. WormBase CDS description: membrane protein
C03F11.4 C03F11.4 P W All gene names: C03F11.4; CE39128; WBGene00015390; WP:CE39128; XG20
C04F12.10 C04F12.10 P W All gene names: Ce-face-1; fce-1; C04F12.10; 1K288; CE19683; NM_060181; WBGene00001405; WP:CE19683 WormBase description: fce-1 encodes an ortholog of 'farnesylated-proteins converting enzyme 1' (FACE-1), and thus probably enables post-translational processing of proteins (such as LET-60/RAS) carrying a C-terminal CaaX motif; FCE-1 protein probably accounts for the EDTA-sensitive, tosylphenylalanylchloromethane-insensitive component of CaaX-proteolytic activity in membrane extracts from C. elegans, and FCE-1 can cleave a farnesylated peptide in vitro; the S. cerevisiae homolog of FCE-1 (Ste24p) cleaves the precursor of yeast a-factor mating pheromone after its farnesylated cysteine residue, and transgenic FCE-1 rescues a mating defect of mutant yeast lacking both the Ste24p and the Rce1p CaaX-proteases. WormBase CDS description: Zinc-binding metalloprotease domain
C04F5.8 C04F5.8 P W All gene names: C04F5.8; 5F590; CE19672; WBGene00015450; WP:CE19672
C05C8.1 C05C8.1 P W All gene names: C05C8.1; 5H721; CE29480; WBGene00015460; WP:CE29480
C05C8.5 C05C8.5 P W All gene names: C05C8.5; 5H714; CE07923; WBGene00015462; WP:CE07923
C05D11.1 C05D11.1 P W All gene names: C05D11.1; 3H529; CE03926; WBGene00015481; WP:CE03926
C05D11.12 C05D11.12 P W All gene names: let-721; C05D11.12; 3H534; CE29662; NM_066014; WBGene00002855; WP:CE29662 WormBase description: The let-721 gene encodes an ortholog of the human gene SIMILAR TO ELECTRON-TRANSFERRING-FLAVOPROTEIN DEHYDROGENASE (ETFDH), which when mutated leads to glutaricaciduria type IIC (OMIM:231675). WormBase CDS description: YAAS
C05D11.9 C05D11.9 P W All gene names: C05D11.9; 3H518; CE24787; WBGene00015486; WP:CE24787
C05D2.10 C05D2.10 P W All gene names: C05D2.10; 3G688; CE26861; CE29560; WBGene00015470; WP:CE26861; WP:CE29560
C06E1.9 C06E1.9 P W All gene names: C06E1.9; 3J696; CE24790; WBGene00015524; WP:CE24790
C06H2.3 C06H2.3 P W All gene names: C06H2.3; 5L609; CE05235; WBGene00007387; WP:CE05235 WormBase description: Acetyltransferase (GNAT) family
C07G2.2 C07G2.2 P W All gene names: atf-7; C07G2.2; 3F582; CE19688; CE33597; CE33598; NM_065512; NM_065513; WBGene00000223; WP:CE19688; WP:CE33597; WP:CE33598 WormBase description: bZIP transcription factor
C07G2.3 C07G2.3 P W All gene names: cct-5; C07G2.3; 3F590; CE02985; CE29569; NM_065514; TCPE_CAEEL; WBGene00000380; WP:CE02985; WP:CE29569 WormBase description: A homolog of the mouse chaperonin Ccte that affects protein folding; it is expressed at all life stages.
C07H6.6 C07H6.6 P W All gene names: clk-2; rad-5; C07H6.6; 3I606; CE30240; NM_066249; WBGene00000537; WP:CE30240 WormBase description: The clk-2 gene encodes an ortholog of the S. cerevisiae telomere length-regulating protein Tel2p that has been shown to bind a number of DNA structures in vitro, including single-, double- and four-stranded DNA; in C. elegans, CLK-2 activity is required for the DNA damage and S phase replication checkpoints, for embryonic development, and for normal biological rhythms and life span; a functional CLK-2::GFP fusion protein is detected exclusively in the cytoplasm of somatic tissues.
C08B11.2 C08B11.2 P W All gene names: hda-2; C08B11.2; 2I312; CE01472; NM_063277; WBGene00001835; WP:CE01472 WormBase description: transcriptional regulatory protein (RPD3)
C08B11.5 C08B11.5 P W All gene names: sap-49; C08B11.5; 2I326; CE36374; WBGene00004723; WP:CE36374 WormBase description: Poly(A) RNA binding protein
C08B6.9 C08B6.9 P W All gene names: aos-1; C08B6.9; 5K608; CE05246; NM_073203; WBGene00000142; WP:CE05246 WormBase description: aos-1 encodes the C. elegans ortholog of Saccharomyces cerevisiae Aos1p and human SUMO-1 activating enzyme E1 N subunit; by homology, AOS-1 is predicted to form, with a catalytic subunit, UBA-2, a heterodimeric enzyme that activates the ubiquitin-like protein SMO-1/SUMO in preparation for its covalent attachment to target proteins to regulate their subcellular localization and/or stability; in C. elegans, AOS-1 is required for embryonic and larval development, as well as for proper Hox gene regulation; uba-2/aos-1(RNAi) animals that survive embryogenesis show ectopic expression of EGL-5 and ectopic anterior sensory ray formation. WormBase CDS description: ubiquitin activating enzyme
C08F8.1 C08F8.1 P W All gene names: pfd-1; C08F8.1; 4L915; CE05248; WBGene00007443; WP:CE05248
C09G12.8 C09G12.8 P W All gene names: ced-10; C09G12.8; 4E272; CE16832; CE16833; NM_067961; RAC1_CAEEL; WBGene00000424; WP:CE16832; WP:CE16833; rac1 WormBase description: ced-10 encodes a GTPase orthologous to human RAC1 (OMIM:602048) that is required for phagocytosis during programmed cell death and for migration of the distal tip cells of the somatic gonad; CED-10 functions in the engulfing cell during apoptosis, and is activated by a complex of CED-2(CrkII) and CED-5(DOCK180) to promote formation of the polarized cell extensions associated with cell corpse engulfment. WormBase CDS description: RAS-related protein
C09G9.1 C09G9.1 P W All gene names: C09G9.1; 4J628; CE03000; WBGene00007492; WP:CE03000
C09H5.2 C09H5.2 P W All gene names: C09H5.2; 5I559; CE24797; CE32578; WBGene00015660; WP:CE24797; WP:CE32578 WormBase description: ATPase
C10G11.5 C10G11.5 P W All gene names: pnk-1; C10G11.5; 1G873; CE29080; CE30488; CE33269; NM_059414; NM_170878; NM_170879; WBGene00004068; WP:CE29080; WP:CE30488; WP:CE33269
C13F10.7 C13F10.7 P W All gene names: C13F10.7; 5H702; CE08148; O01489_CAEEL; WBGene00015746; WP:CE08148
C14A4.14 C14A4.14 P W All gene names: C14A4.14; 2K875; CE24801; WBGene00007564; WP:CE24801
C14A4.2 C14A4.2 P W All gene names: dap-3; C14A4.2; 2K873; CE24802; NM_063879; WBGene00000933; WP:CE24802 WormBase description: dap-3 is an ortholog of mammalian death-associated protein 3 (DAP3), a mitochondrial ribosomal protein that promotes apoptosis.
C14A4.3 C14A4.3 P W All gene names: C14A4.3; CE32796; NM_063881; WBGene00007556; WP:CE32796
C14B1.10 C14B1.10 P W All gene names: C14B1.10; 3E801; CE28888; WBGene00007581; WP:CE28888
C14C10.2 C14C10.2 P W All gene names: C14C10.2; 5N72; CE28432; CE39471; WBGene00007585; WP:CE28432; WP:CE39471 WormBase description: Transthyretin-like family
C14F5.4 C14F5.4 P W All gene names: C14F5.4; CE30370; WBGene00015777; WP:CE30370; XI576
C15C8.7 C15C8.7 P W All gene names: C15C8.7; 5N224; CE27580; WBGene00007609; WP:CE27580
C15F1.3 C15F1.3 P W All gene names: tra-2; C15F1.3; C15F1.F; 2H246; CE23546; CE23547; NM_063025; TRA2_CAEEL; WBGene00006605; WP:CE23546; WP:CE23547 WormBase description: The tra-2 gene encodes a transmembrane receptor that functions in the sex determination pathway to specify female fates in hermaphroditic XX animals; tra-2 encodes two proteins: TRA-2A, the major protein expressed at all developmental stages, and TRA-2B, a form specific to the hermaphrodite germ line; in hermaphrodites, direct interaction between the TRA-2A intracellular domain inhibits FEM-3 masculinizing activity, whereas in males, TRA-2A is negatively regulated by HER-1, allowing the FEM proteins to specify male development.
C15H11.7 C15H11.7 P W All gene names: pas-1; C15H11.7; 5O902; CE08184; NM_074170; WBGene00003922; WP:CE08184 WormBase description: pas-1 encodes a type 6 alpha subunit of the 26S proteasome's 20S protease core particle (CP); PAS-1 is required for embryonic development and by homology, is predicted to comprise the outer rings of the proteasome and to play a role in selective degradation of ubiquitinated proteins during development; in vitro, PAS-1 interacts with VET-1, a coiled-coil domain-containing protein expressed in the early embryo and ATN-1, an alpha-actinin, in addition to other members of the proteasome. WormBase CDS description: proteasome component (A-type)
C16A3.4 C16A3.4 P W All gene names: C16A3.4; 3H473; CE04004; WBGene00015809; WP:CE04004
C16A3.6 C16A3.6 P W All gene names: C16A3.6; 3H469; CE04006; WBGene00015811; WP:CE04006
C16C10.1 C16C10.1 P W All gene names: C16C10.1; 3F270; CE33519; WBGene00007622; WP:CE33519 WormBase description: carrier protein
C16C10.6 C16C10.6 P W All gene names: C16C10.6; 3F258; CE01497; WBGene00007627; WP:CE01497
C16C10.7 C16C10.7 P W All gene names: rnf-5; C16C10.7; 3F254; CE01498; NM_065429; RNF5_CAEEL; WBGene00004381; WP:CE01498 WormBase description: This gene encodes a homolog of mammalian RNF5, a C3HC4 (RING-finger) zinc-finger protein. WormBase CDS description: Zinc finger, C3HC4 type (RING finger)
C16C10.8 C16C10.8 P W All gene names: C16C10.8; 3F252; CE01499; WBGene00007628; WP:CE01499 WormBase description: cell growth regulating protein
C17E4.10 C17E4.10 P W All gene names: C17E4.10; 1K15; CE32589; Q93231_CAEEL; WBGene00007647; WP:CE32589
C17G10.1 C17G10.1 P W All gene names: C17G10.1; 2F887; CE01785; WBGene00015915; WP:CE01785
C17G10.8 C17G10.8 P W All gene names: dhs-6; C17G10.8; CED6.1; 2F906; CE02490; WBGene00000970; WP:CE02490 WormBase description: The dhs-6 locus is predicted to encode four transcripts derived from alternative splicing and alternative transcriptional initiation sites; the longest transcript is predicted to encode a member of the eukaryotic translation initiation factor family within its amino-terminal end, and is a member of both the SCP-2 sterol transfer family and short-chain dehydrogenase-reductase families within its carboxyl-terminal end; DHS-6 is predicted to be mitochondrial. WormBase CDS description: Alcohol dehydrogenase
C18A3.3 C18A3.3 P W All gene names: C18A3.3; 2G7; CE28890; WBGene00015941; WP:CE28890
C18E3.4 C18E3.4 P W All gene names: C18E3.4; 1E769; CE08313; WBGene00015973; WP:CE08313
C23H3.5 C23H3.5 P W All gene names: C23H3.5; 2A339; CE08324; WBGene00016021; WP:CE08324
C24A11.9 C24A11.9 P W All gene names: tag-134; C24A11.9; 1F982; CE29183; NM_059187; WBGene00000761; WP:CE29183 WormBase description: coq-1 encodes a putative hexaprenyl pyrophosphate synthetase, orthologous to S. cerevisiae COQ1; COQ-1 is required for ubiquinone (coenzyme Q9) biosynthesis and for normally short lifespan; coq-1 mutants have slowed pharyngeal pumping, and eventually arrest as paralysed larvae before dying; coq-1(RNAi) animals have reduced levels of coenzyme Q9 and superoxide, and have abnormally long lifespans; coq-1 mutants are not rescued by dietary coenzyme Q. WormBase CDS description: hexaprenyl pyrophosphate synthetase
C24F3.4 C24F3.4 P W All gene names: C24F3.4; 4K980; CE18521; WBGene00007698; WP:CE18521
C24G6.3 C24G6.3 P W All gene names: C24G6.3; 5F999; CE29673; WBGene00016060; WP:CE29673
C25A1.7 C25A1.7 P W All gene names: irs-2; C25A1.7; 1K759; CE35957; NM_060279; WBGene00002153; WP:CE35957 WormBase description: irs-2 encodes a predicted mitochondrial isoleucyl-tRNA synthetase (IleRS), a class I aminoacyl-tRNA synthetase that catalyzes the attachment of isoleucine to its cognate tRNA and is thus required for protein biosynthesis; loss of irs-2 activity via RNA-mediated interference (RNAi) in the hypersensitive rrf-3 strain results in thin animals who grow at slower rates than wild type, indicating that IRS-2 plays a role in regulation of postembryonic growth. WormBase CDS description: isoleucyl-tRNA synthetase (mitochondrial)
C25G4.2 C25G4.2 P W All gene names: C25G4.2; 4N208; CE05303; WBGene00007730; WP:CE05303 WormBase description: dihydrofolate reductase like
C26E6.3 C26E6.3 P W All gene names: C26E6.3; 3G35; CE32144; WBGene00016139; WP:CE32144 WormBase description: cell differentiation family, Rcd1-like
C26E6.8 C26E6.8 P W All gene names: ula-1; C26E6.8; 3G8; CE29678; NM_065636; WBGene00006735; WP:CE29678 WormBase description: The ula-1 gene encodes a component of the enzyme that activates NED-8, which in turn is a ubiquitin-like protein whose conjugating enzyme is UBC-12.
C26F1.3 C26F1.3 P W All gene names: C26F1.3; 5I259; CE06877; WBGene00016148; WP:CE06877
C27A12.2 C27A12.2 P W All gene names: C27A12.2; 1G621; CE08411; O01961_CAEEL; WBGene00016154; WP:CE08411 WormBase description: zinc finger protein
C27A12.6 C27A12.6 P W All gene names: C27A12.6; 1G630; CE08415; WBGene00016156; WP:CE08415
C27A12.7 C27A12.7 P W All gene names: C27A12.7; 1G634; CE08416; CE32810; WBGene00016157; WP:CE08416; WP:CE32810
C27A12.8 C27A12.8 P W All gene names: ari-1; C27A12.8; 1G636; CE29680; NM_059348; WBGene00016158; WP:CE29680
C27B7.1 C27B7.1 P W All gene names: spr-2; C27B7.1; 4J657; CE03030; CE27804; NM_069142; SPR2_CAEEL; WBGene00005007; WP:CE03030; WP:CE27804 WormBase description: spr-2 encodes the C. elegans ortholog of the Drosophila and mammalian SET proteins (OMIM:600960, translocation breakpoint in human SET is associated with acute myeloid leukemia); SPR-2 is predicted to be a member of the SET protein complex that functions in chromatin remodeling, DNA repair, and transcriptional regulation; in C. elegans, SPR-2 may function to regulate the activity and/or levels of the presenilin proteins encoded by sel-12 and hop-1, as mutations in spr-2 suppress mutations in sel-12 in a hop-1-dependent manner; spr-2 is detected in the nuclei of all cells at several developmental stages, including the L3 larval stage.
C28C12.9 C28C12.9 P W All gene names: gei-9; C28C12.9; 4J262; CE28892; CE32595; CE32596; NM_069051; NM_182280; NM_182281; WBGene00001566; WP:CE28892; WP:CE32595; WP:CE32596 WormBase description: gei-9 encodes a protein containing a putative acyl-CoA dehydrogenase domain; interacts with GEX-3 in yeast two-hybrid assays.
C28D4.1 C28D4.1 P W All gene names: nhr-100; C28D4.1; 4K497; CE28893; NM_069330; WBGene00003690; WP:CE28893 WormBase description: nhr-100 encodes a member of the superfamily of nuclear receptors, which is one of the most abundant class of transcriptional regulators; nuclear receptors have a well conserved DNA binding domain and a less conserved C-terminal ligand binding domain. WormBase CDS description: Ligand-binding domain of nuclear hormone receptors, Zinc finger, C4 type
C29F9.3 C29F9.3 P W All gene names: C29F9.3; 3A743; CE28896; CE30623; CE30624; WBGene00016218; WP:CE28896; WP:CE30623; WP:CE30624
C29H12.1 C29H12.1 P W All gene names: rrt-2; C29H12.1; 2G417; CE17479; NM_062826; WBGene00004680; WP:CE17479 WormBase description: arginyl-tRNA synthetase
C30C11.1 C30C11.1 P W All gene names: C30C11.1; 3J539; CE00100; WBGene00016249; WP:CE00100
C30G12.6 C30G12.6 P W All gene names: C30G12.6; 2H584; CE29205; CE29206; WBGene00016277; WP:CE29205; WP:CE29206
C30H7.2 C30H7.2 P W All gene names: C30H7.2; 1F986; CE27807; CE39231; WBGene00016278; WP:CE27807; WP:CE39231
C32D5.9 C32D5.9 P W All gene names: lgg-1; C32D5.9; 2G636; CE01849; LGG1_CAEEL; NM_062876; WBGene00002980; WP:CE01849
C33H5.11 C33H5.11 P W All gene names: imp-3; C33H5.11; 4I552; CE29696; NM_068885; WBGene00016378; WP:CE29696
C33H5.17 C33H5.17 P W All gene names: C33H5.17; 4I576; CE04160; WBGene00016383; WP:CE04160
C33H5.9 C33H5.9 P W All gene names: sec-10; C33H5.9; 4I544; CE04152; WBGene00016376; WP:CE04152
C34B2.10 C34B2.10 P W All gene names: phi-56; C34B2.10; 1L258; CE16898; WBGene00016395; WP:CE16898
C34C6.4 C34C6.4 P W All gene names: C34C6.4; 2I988; CE03052; WBGene00007917; WP:CE03052 WormBase description: choline dehydrogenase
C34E10.1 C34E10.1 P W All gene names: gop-3; C34E10.1; 3G351; CE26880; NM_065718; WBGene00001662; WP:CE26880 WormBase description: gop-3 encodes an ortholog of the mammalian CGI-51 (comparative gene identification-51) proteins that display a high degree of similarity to the Haemophilus influenza D15 protective surface antigen; loss of gop-3 activity via large-scale RNAi screens indicates that GOP-3 is required for embryonic and larval development, as well as for normal postembryonic growth rates.
C34E10.2 C34E10.2 P W All gene names: gop-2; C34E10.2; 3G349; CE01182; GOP2_CAEEL; NM_065717; WBGene00001661; WP:CE01182 WormBase description: gop-2 encodes a member of the conserved hypothetical ATP binding protein family that affects embryonic viability, growth, and fertility.
C34E10.4 C34E10.4 P W All gene names: wrs-2; C34E10.4; 3G327; CE29032; CE37710; WBGene00006946; WP:CE29032; WP:CE37710 WormBase description: wrs-2 encodes a tryptophanyl (W) tRNA synthetase predicted to be mitochondrial.
C34E10.5 C34E10.5 P W All gene names: tag-251; C34E10.5; 3G323; CE29033; WBGene00016408; WP:CE29033
C35B1.1 C35B1.1 P W All gene names: ubc-1; C35B1.1; 4E869; CE27822; NM_068079; UBC1_CAEEL; WBGene00006701; WP:CE27822 WormBase description: ubc-1 encodes an E2 ubiquitin-conjugating enzyme that contains a novel 40 amino acid C-terminal tail, and is homologous to Saccharomyces cerevisiae RAD6/UBC2 which is involved in DNA repair; although loss of UBC-1 activity via RNA-mediated interference (RNAi) does not result in any abnormalities, UBC-1 is able to complement the DNA repair defects of a Saccharomyces cerevisiae rad6 null mutant, suggesting that UBC-1 can function in the DNA repair pathway; ubc-1 mRNA is detectable in embryos. WormBase CDS description: ubiquitin conjugating-protein
C35D10.1 C35D10.1 P W All gene names: C35D10.1; 3F971; CE29951; WBGene00016439; WP:CE29951
C37F5.1 C37F5.1 P W All gene names: lin-1; C37F5.1; 4D42; CE31440; WBGene00002990; WP:CE31440 WormBase description: lin-1 encodes an Ets-domain-containing transcription factor that is a member of the ETS gene family that includes human ELK1, 3, and 4 (OMIM:600247); LIN-1 functions as a general effector of MAP kinase-mediated signaling; when MAP kinase is inactive, LIN-1 forms a complex with LIN-31/WH that inhibits vulval cell fate specification; upon MAP kinase activation (vulval induction), LIN-1 is phosphorylated, dissociates from LIN-31, and becomes inactive, thus allowing for vulval development.
C37H5.6 C37H5.6 P W All gene names: C37H5.6; 5F298; CE08630; CE29709; WBGene00016509; WP:CE08630; WP:CE29709 WormBase description: adenylosuccinate synthetase
C38C10.2 C38C10.2 P W All gene names: C38C10.2; 3K478; CE08647; WBGene00008000; WP:CE08647 WormBase description: C38C10.2 is orthologous to the human gene SOLUTE CARRIER FAMILY 17 (ANION/SUGAR TRANSPORTER), MEMBER 5 (SLC17A5; OMIM:604322), which when mutated leads to disease. WormBase CDS description: Sodium/phosphate transporter
C38D4.5 C38D4.5 P W All gene names: tag-325; C38D4.5; 3F891; CE00918; WBGene00008006; WP:CE00918 WormBase description: chimaerin
C38D4.9 C38D4.9 P W All gene names: C38D4.9; 3F893; CE00922; Q18511_CAEEL; WBGene00008008; WP:CE00922 WormBase description: methylase
C39E9.13 C39E9.13 P W All gene names: rfc-3; C39E9.13; 4N861; CE05396; NM_070116; Q18547_CAEEL; WBGene00004339; WP:CE05396 WormBase description: Human activator 1 38 KD subunit like
C41D11.8 C41D11.8 P W All gene names: cps-6; C41D11.8; 1F14; CE29488; NM_058970; NUCG_CAEEL; WBGene00000787; WP:CE29488 WormBase description: cps-6 encodes an ortholog of human mitochondrial endonuclease G (EndoG) that promotes apoptosis, and is required to degrade nicked (TUNEL-positive) DNA in apoptotic cells; transgenic CPS-6 is localized to mitochondria, but transgenic CPS-6 lacking a mitochondrial localization sequence is found in nuclei, and nuclei may be the in vivo target of CPS-6 after its activation by CED-3; CPS-6 has magnesium-dependent nuclease activity in vitro; cps-6(sm116) and cps-6(RNAi) animals have delayed CED-3-induced apoptosis, and cps-6(sm116) suppresses a constitutively active ced-3 transgene; cps-6(sm116) can be transgenically rescued by mouse EndoG; CPS-6 binds WAH-1 (an apoptosis-inducing factor ortholog) in vitro, WAH-1 binding enhances CPS-6's endonuclease activity, and constitutive transgenic coexpression of cps-6 with wah-1 induces cell death not seen with constitutive expression of either cps-6 or wah-1 alone; CPS-6 binds CRN-1 (a flap endonuclease ortholog) in vitro, and may form a large complex in vivo with CRN-1, CRN-4, CRN-5, CYP-13, and WAH-1; CRN-1 enhances CPS-6's endonuclease activity in vitro, CPS-6 enhances CRN-1's gap-dependent endonuclease and 5'-3' exonuclease activities, and cps-6 is required for excess cell deaths induced by a crn-1 transgene.
C41H7.5 C41H7.5 P W All gene names: C41H7.5; 2D293; CE32164; WBGene00016575; WP:CE32164
C41H7.6 C41H7.6 P W All gene names: C41H7.6; 2D291; CE08677; WBGene00016576; WP:CE08677
C42C1.11 C42C1.11 P W All gene names: AP-1; C42C1.11; 4N45; CE24840; CE33564; CE33565; WBGene00016589; WP:CE24840; WP:CE33564; WP:CE33565 WormBase description: peptidase
C43E11.2 C43E11.2 P W All gene names: mus-81; C43E11.2; 1E835; CE08680; CE32609; WBGene00016602; WP:CE08680; WP:CE32609
C44B7.10 C44B7.10 P W All gene names: C44B7.10; 2H180; CE32326; WBGene00016630; WP:CE32326
C44E4.3 C44E4.3 P W All gene names: C44E4.3; 1F206; CE34271; WBGene00016652; WP:CE34271 WormBase description: aminotransferase
C44E4.5 C44E4.5 P W All gene names: C44E4.5; 1F177; CE08719; WBGene00016654; WP:CE08719
C46F11.5 C46F11.5 P W All gene names: C46F11.5; 3E744; CE31448; CE31449; WBGene00008120; WP:CE31448; WP:CE31449
C47B2.2 C47B2.2 P W All gene names: C47B2.2; CE17562; CE23599; WBGene00008131; WP:CE17562; WP:CE23599
C47D12.2 C47D12.2 P W All gene names: C47D12.2; 2L967; CE20567; Q18668_CAEEL; WBGene00008136; WP:CE20567 WormBase description: C47D12.2 encodes an ortholog of human FLJ20071/FLJ90130 (dymeclin, OMIM:607461, mutated in Dyggve-Melchior-Clausen dysplasia and Smith-McCort dysplasia), which has no obvious function in mass RNAi assays
C47D12.6 C47D12.6 P W All gene names: trs-1; C47D12.6; 2L982; CE05434; CE33765; WBGene00006617; WP:CE05434; WP:CE33765 WormBase description: threonyl-tRNA synthetase (cytoplasmic)
C47E12.5 C47E12.5 P W All gene names: uba-1; C47E12.5; 4K754; CE05449; CE39093; NM_069399; WBGene00006699; WP:CE05449; WP:CE39093 WormBase description: uba-1 encodes a ubiquitin-activating enzyme orthologous to Saccharomyces cerevisiae UBA1 and human UBE1; UBA-1 is essential for embryogenesis and is required for germline development; by homology, UBA-1 is predicted to function in an ATP-dependent reaction that activates ubiquitin prior to its conjugation to proteins that will subsequently be degraded by the 26S proteasome; a uba-1 transcriptional reporter fusion is expressed in the larval intestine.
C47G2.3 C47G2.3 P W All gene names: C47G2.3; 2L578; CE25820; WBGene00008164; WP:CE25820
C48B6.2 C48B6.2 P W All gene names: C48B6.2; 1H493; CE08804; WBGene00016740; WP:CE08804 WormBase description: ribosomal protein
C48E7.3 C48E7.3 P W All gene names: lpd-2; C48E7.3; 1G831; CE29953; NM_059405; WBGene00003059; WP:CE29953 WormBase description: lpd-2 encodes a predicted transcription factor with homology to transcription factors of the CCAAT/Enhancer Binding Protein family (C/EBPA and B, OMIM:116897, 189965, associated with the regulation of mammalian adipocyte differentiation); in C. elegans, LPD-2 activity is required for normal lipid metabolism and wild-type levels of lipogenic enzyme expression, as well as for larval development; in addition, LPD-2 may be part of a conserved pathway regulating lipogenesis, as LPD-2 appears to positively regulate expression of sbp-1, which encodes the C. elegans Sterol Regulatory Element Binding Protein (SREBP) homolog, a basic helix-loop-helix-type transcription factor also required for normal lipid metabolism and larval development.
C50D2.7 C50D2.7 P W All gene names: C50D2.7; 2A382; CE33040; WBGene00016810; WP:CE33040
C50F4.16 C50F4.16 P W All gene names: C50F4.16; 5K18; CE28213; WBGene00008238; WP:CE28213 WormBase description: The C50F4.16 gene encodes a NUDIX hydrolase.
C52E12.3 C52E12.3 P W All gene names: sqv-7; C52E12.3; 2H302; CE04263; NM_063035; WBGene00005025; WP:CE04263 WormBase description: The sqv-7 gene encodes a nucleotide-sugar transporter of the Golgi membrane, that is required for cytokinesis of one-cell embryos and for vulval morphogenesis; SQV-7 promotes glycosaminoglycan biosynthesis by translocating UDP-glucuronic acid, UDP-N-acetylgalactosamine, and UDP-galactose into the lumen of the Golgi apparatus; SQV-7 is biochemically active when transgenically expressed in yeast or mammalian Golgi membranes; the common requirement for SQV-7 in both cytokinesis and morphogenesis may be to promote filling an extracellular space with hygroscopic proteoglycans (either in the eggshell, or underneath the L4 cuticle), which in turn may cause the space to fill with fluid.
C52E4.2 C52E4.2 P W All gene names: mif-2; C52E4.2; 5M458; CE08944; NM_073602; WBGene00003235; WP:CE08944 WormBase description: macrophage migration inhibitory factor like protein
C53A5.2 C53A5.2 P W All gene names: C53A5.2; 5P0; CE17599; WBGene00008263; WP:CE17599 WormBase description: Neurospora met-10 protein like
C53H9.1 C53H9.1 P W All gene names: rpl-27; C53H9.1; 1C309; CE19381; NM_058504; WBGene00004441; WP:CE19381 WormBase description: rpl-27 encodes a large ribosomal subunit L27 protein. WormBase CDS description: 60S ribosomal protein L27
C54G4.7 C54G4.7 P W All gene names: C54G4.7; CE05513; NM_059805; Q18852_CAEEL; WBGene00008317; WP:CE05513
C54G4.9 C54G4.9 P W All gene names: C54G4.9; 1I602; CE05515; WBGene00008318; WP:CE05515
C55A6.2 C55A6.2 P W All gene names: C55A6.2; 5L991; CE29733; WBGene00008331; WP:CE29733 WormBase description: Human KIAA0173 protein like
C55B7.8 C55B7.8 P W All gene names: Ce-dbr1; dbr-1; C55B7.8; 1H68; CE30437; DBR1_CAEEL; NM_059467; WBGene00000937; WP:CE30437 WormBase description: dbr-1 encodes a homolog of the RNA lariat-debranching enzyme; DBR-1 is predicted to function in RNA processing by hydrolyzing the 2'-5' phosphodiester bond at the branchpoint of excised lariat intron RNA, thus converting the introns into linear molecules that can subsequently be degraded by exonucleases; in C. elegans, DBR-1 activity is required for embryonic and germline development, as well as for normal rates of postembryonic growth; overexpression of C. elegans DBR-1 in Saccharomyces cerevisiae can complement the RNA processing defects of a dbr1 null mutant strain, restoring debranching activity and intron degradation to near wild-type levels. WormBase CDS description: lariat debranching enzyme
C56C10.7 C56C10.7 P W All gene names: C56C10.7; 2G876; CE29739; CE29740; Q95QQ3_CAEEL; WBGene00016964; WP:CE29739; WP:CE29740
D1005.1 D1005.1 P W All gene names: D1005.1; CE06997; WBGene00016995; WP:CE06997; XC101 WormBase description: ATP citrate lyase
D1007.11 D1007.11 P W All gene names: D1007.11; WBGene00043224
D1007.5 D1007.5 P W All gene names: D1007.5; 1F150; CE29034; CE33577; WBGene00017003; WP:CE29034; WP:CE33577
D1037.3 D1037.3 P W All gene names: ftn-2; D1037.3; 1E248; CE20622; NM_058797; Q9TYS3_CAEEL; WBGene00001501; WP:CE20622 WormBase description: ftn-2 encodes one of two C. elegans ferritin heavy chain homologs; loss of ftn-2 activity via deletion mutation results in slightly lower brood sizes and, under iron stress conditions, slightly faster growth from the L4 to adult stage of development, and slightly reduced lifespan; an ftn-2::gfp reporter fusion is expressed in diverse tissues, including the pharynx, intestine, and hypodermis, and its expression, along with that of ftn-2 mRNA, does not appear to change significantly under iron stress conditions. WormBase CDS description: ferritin
D1043.1 D1043.1 P W All gene names: D1043.1; 2L877; CE32842; WBGene00008361; WP:CE32842
D1054.13 D1054.13 P W All gene names: secs-1; D1054.13; 5L284; CE05531; UGTAP_CAEEL; WBGene00008379; WP:CE05531
D2013.2 D2013.2 P W All gene names: wdfy-2; D2013.2; 2J611; CE00928; WBGene00008402; WP:CE00928; YLN2_CAEEL WormBase description: beta-transducin
D2013.7 D2013.7 P W All gene names: eif-3.F; D2013.7; 2J623; CE00932; NM_063587; WBGene00001229; WP:CE00932 WormBase description: M0V-34 protein
D2024.5 D2024.5 P W All gene names: D2024.5; 4H992; CE27896; CE31460; WBGene00017053; WP:CE27896; WP:CE31460
D2030.3 D2030.3 P W All gene names: D2030.3; 1I154; CE09080; WBGene00008413; WP:CE09080
D2030.8 D2030.8 P W All gene names: D2030.8; 1I169; CE28545; WBGene00008418; WP:CE28545
D2045.9 D2045.9 P W All gene names: D2045.9; CE33988; Q18989_CAEEL; WBGene00008426; WP:CE33988
DY3.4 DY3.4 P W All gene names: trt-1; DY3.4; 1J347; CE15748; CE27901; CETERT; NM_059972; NM_059973; WBGene00006618; WP:CE15748; WP:CE27901 WormBase description: trt-1 encodes C. elegans telomerase reverse transcriptase that affects fertility, maintenance of telomere length, and chromosome nondisjunction. WormBase CDS description: Reverse transcriptase (RNA-dependent DNA polymerase)
E02A10.1 E02A10.1 P W All gene names: E02A10.1; 5N45; CE09115; WBGene00008452; WP:CE09115 WormBase description: mitochondrial 40S ribosomal protein S5
E02H1.5 E02H1.5 P W All gene names: E02H1.5; 2J885; CE01540; WBGene00008457; WP:CE01540
E02H1.6 E02H1.6 P W All gene names: E02H1.6; 2J887; CE28286; WBGene00008458; WP:CE28286 WormBase description: E02H1.6 encodes an ortholog of human TAF9 (OMIM:600822; also known as AK6, adrenal gland protein AD-004 like protein, ADLP) and of S. cerevisiae Fap7p; like its human ortholog, E02H1.6 is nuclear, and is predicted to likewise be a TATA box binding protein (TBP)-associated factor mediating activation of RNA polymerase II; E02H1.6 prefers ATP and dATP as phosphate donors; E02H1.6's biochemical activity is unusual, since it also prefers AMP and dAMP as substrates, and tolerates CMP, TMP and shikimate acid as substrates as well; since yeast Fap7p promotes pre-rRNA cleavage, E02H1.6 may be multifunctional; in RNAi assays, E02H1.6 is required for normally fast growth. WormBase CDS description: ATP binding protein
E04A4.7 E04A4.7 P W All gene names: cyc-2.1; E04A4.7; CE16968; NM_068228; WBGene00017121; WP:CE16968 WormBase description: cytochrome C
EEED8.9 EEED8.9 P W All gene names: pink-1; EEED8.9; 2F684; CE28904; NM_062616; WBGene00017137; WP:CE28904 WormBase description: pink-1 encodes a predicted serine/threonine protein kinase that is most similar to the Drosophila and human PINK1 (PTEN-induced kinase) protein kinases, the latter of which has been implicated in familial forms of Parkinson's disease; although loss of C. elegans pink-1 activity via large-scale RNAi screens results in no obvious abnormalities, studies in Drosophila indicate that Drosophila PINK1 is a mitochondrial protein that genetically interacts with Drosophila parkin and is essential for maintaining mitochondrial function and integrity in several tissues, including flight muscles and dopaminergic neurons.
F01F1.5 F01F1.5 P W All gene names: dpf-4; F01F1.5; 3G951; CE01231; NM_065863; WBGene00001057; WP:CE01231
F01G10.1 F01G10.1 P W All gene names: F01G10.1; 4L9; CE09163; WBGene00008506; WP:CE09163 WormBase description: The F01G10.1 gene encodes an ortholog of the human gene TRANSKETOLASE (TKT; OMIM:606781), which when mutated leads to Wernicke-Korsakoff syndrome (OMIM:277730). WormBase CDS description: transketolase
F01G4.5 F01G4.5 P W All gene names: F01G4.5; 4L910; CE03130; WBGene00008504; WP:CE03130
F02E9.10 F02E9.10 P W All gene names: F02E9.10; 1J4; CE27119; CE38314; WBGene00008533; WP:CE27119; WP:CE38314
F07H5.10 F07H5.10 P W All gene names: F07H5.10; 2J98; CE28906; WBGene00008561; WP:CE28906
F08B4.5 F08B4.5 P W All gene names: F08B4.5; 4J448; CE29749; WBGene00017237; WP:CE29749
F08F1.7 F08F1.7 P W All gene names: tag-123; F08F1.7; CE09254; WBGene00006472; WP:CE09254; XJ38
F08F8.9 F08F8.9 P W All gene names: F08F8.9; 3I440; CE27936; CE27937; CE30651; Q95ZV9_CAEEL; WBGene00017274; WP:CE27936; WP:CE27937; WP:CE30651
F09E5.1 F09E5.1 P W All gene names: pkc-3; F09E5.1; 2F673; CE02604; KPC3_CAEEL; NM_062610; WBGene00004034; WP:CE02604 WormBase description: Protein kinase C
F09E5.5 F09E5.5 P W All gene names: sec-6; F09E5.5; 2F661; CE29752; WBGene00017284; WP:CE29752
F09G2.8 F09G2.8 P W All gene names: F09G2.8; 5H670; CE09303; WBGene00017316; WP:CE09303
F10C5.1 F10C5.1 P W All gene names: apc-8; mat-3; pod-4; vex-2; F10C5.1; 3B99; CE26888; NM_064802; Q19294_CAEEL; WBGene00003134; WP:CE26888
F10G7.1 F10G7.1 P W All gene names: tag-151; F10G7.1; 2F3; CE02624; WBGene00006497; WP:CE02624
F11A10.2 F11A10.2 P W All gene names: F11A10.2; 4M849; CE28910; Q19335_CAEEL; WBGene00008683; WP:CE28910
F11C1.2 F11C1.2 P W All gene names: F11C1.2; CE31472; WBGene00008691; WP:CE31472; XN604
F11G11.5 F11G11.5 P W All gene names: F11G11.5; CE07058; NM_062473; WBGene00017385; WP:CE07058
F12F6.3 F12F6.3 P W All gene names: rib-1; F12F6.3; 4M347; CE24898; NM_069779; WBGene00004360; WP:CE24898 WormBase description: The rib-1 gene encodes an ortholog of human EXT1, which when mutated leads to hereditary multiple exostoses, type I (OMIM:133700). WormBase CDS description: MULTIPLE EXOSTOSES HOMOLOG 1
F13G3.5 F13G3.5 P W All gene names: ttx-7; F13G3.5; 1H878; CE29761; CE40939; WBGene00008765; WP:CE29761; WP:CE40939 WormBase description: myo-inositol-1-monophosphatase
F13G3.7 F13G3.7 P W All gene names: F13G3.7; 1H881; CE31477; CE37822; WBGene00008767; WP:CE31477; WP:CE37822 WormBase description: Yeast mitochondrial carrier protein like
F13H10.2 F13H10.2 P W All gene names: ndx-9; F13H10.2; 4L776; CE35474; NM_069650; WBGene00003586; WP:CE35474 WormBase description: The ndx-9 gene encodes a member of the NADH pyrophosphatase subfamily of the NUDIX hydrolases. WormBase CDS description: NADH pyrophosphatase
F13H10.3 F13H10.3 P W All gene names: F13H10.3; 4L778; CE27959; CE30342; CE40353; WBGene00008774; WP:CE27959; WP:CE30342; WP:CE40353 WormBase description: Yeast YEH4 like protein
F16D3.2 F16D3.2 P W All gene names: rsd-6; F16D3.2; 1I936; CE32384; NM_059868; WBGene00004684; WP:CE32384
F17C11.7 F17C11.7 P W All gene names: F17C11.7; 5L438; CE05654; CE37354; WBGene00008918; WP:CE05654; WP:CE37354
F18A1.2 F18A1.2 P W All gene names: lin-26; F18A1.2; 2H973; CE27972; WBGene00003012; WP:CE27972 WormBase description: lin-26 encodes a zinc-finger protein that shares a unique C2H2 motif together with LIR-1, LIR-2, and LIR-3; during development, lin-26 activity is required for proper differentiation of non-neuronal ectodermal cells and the somatic gonad epithelium; LIN-26 is expressed in many different cell types including the rectal rep, somatic gonad, glial, and hypodermal cells; ectopic LIN-26 expression during embryogenesis induces epithelial-like cell fates suggesting that LIN-26 is sufficient for epithelial differentiation. WormBase CDS description: transcription factor
F18C5.2 F18C5.2 P W All gene names: wrn-1; F18C5.2; 2G849; CE31791; NM_062923; WBGene00006944; WP:CE31791 WormBase description: wrn-1 encodes an ortholog of human WRN, which when mutated leads to Werner syndrome (OMIM:277700), and one of four C. elegans homologs of the RecQ DNA helicase family that includes E. coli RecQ; by homology, WRN-1 is predicted to function as a helicase, DNA-dependent ATPase, and exonuclease that plays a key role in DNA replication, recombination, and repair; in C. elegans, loss of wrn-1 activity, via mutation or large-scale RNA-mediated interference (RNAi) screens, does not result in any obvious abnormalities, as animals are viable and fertile, have normal lifespans, and do not appear to have a high rate of genomic instability.
F20C5.6 F20C5.6 P W All gene names: F20C5.6; 4J536; CE03243; Q18379_CAEEL; WBGene00008971; WP:CE03243 WormBase description: spectrin
F20D1.3 F20D1.3 P W All gene names: F20D1.3; CE31486; WBGene00008975; WP:CE31486; XP595
F21C3.4 F21C3.4 P W All gene names: mut-8; rde-2; F21C3.4; 1H858; CE37005; CE38174; NM_059656; Q19672_CAEEL; WBGene00004324; WBGene00009003; WP:CE37005; WP:CE38174 WormBase description: rde-2 encodes a novel protein that is conserved in at least two other Caenorhabditis species; rde-2 is required for the functional silencing of chromosomal loci by transgenes (cosuppression) and promotes the effects of RNAi in a step after the formation of a heritable interfering agent, also affects X-chromosome nondisjunction and transposon activation; functions downstream of rde-1 in the RNAi pathway most effective against germline, but not somatically expressed, genes; RDE-2 is present predominantly in the cytosol, in complexes with MUT-7, a predicted exoribonuclease also required for RNA interference.
F21D5.5 F21D5.5 P W All gene names: F21D5.5; 4J500; CE27135; WBGene00009010; WP:CE27135 WormBase description: polynucleotide kinase 3' phosphatase
F22B5.10 F22B5.10 P W All gene names: F22B5.10; 2I757; CE02196; WBGene00009045; WP:CE02196
F22B5.9 F22B5.9 P W All gene names: frs-2; F22B5.9; 2I755; CE20708; WBGene00001498; WP:CE20708 WormBase description: phenylalanyl-tRNA synthetase
F23B12.7 F23B12.7 P W All gene names: F23B12.7; 5O931; CE09599; WBGene00009084; WP:CE09599 WormBase description: CCAAT binding factor 1 protein like
F23C8.5 F23C8.5 P W All gene names: F23C8.5; F23C8.G; 1C986; CE29774; WBGene00017734; WP:CE29774 WormBase description: The F23C8.5 gene encodes an ortholog of the human gene ELECTRON TRANSFER FLAVOPROTEIN BETA SUBUNIT (ETFB), which when mutated leads to glutaricaciduria type IIB (OMIM:130410). WormBase CDS description: electron transfer flavoprotein beta
F25B5.5 F25B5.5 P W All gene names: F25B5.5; 3H34; CE01922; CK5P1_CAEEL; WBGene00017776; WP:CE01922
F25G6.8 F25G6.8 P W All gene names: F25G6.8; 5J44; CE09644; WBGene00017799; WP:CE09644
F25H2.11 F25H2.11 P W All gene names: tct-1; F25H2.11; 1L147; CE09656; NM_060366; TCTP_CAEEL; WBGene00009122; WP:CE09656 WormBase description: TCTP protein
F25H2.12 F25H2.12 P W All gene names: F25H2.12; 1L149; CE09657; CE32637; WBGene00009123; WP:CE09657; WP:CE32637
F25H5.3 F25H5.3 P W All gene names: F25H5.3; 1J753; CE15898; CE15899; CE36135; CE37832; O17835_CAEEL; WBGene00009126; WP:CE15898; WP:CE15899; WP:CE36135; WP:CE37832 WormBase description: Pyruvate kinase
F25H5.6 F25H5.6 P W All gene names: F25H5.6; 1J734; CE29591; WBGene00009128; WP:CE29591
F26E4.11 F26E4.11 P W All gene names: hrdl-1; F26E4.11; 1K371; CE09695; WBGene00009164; WP:CE09695 WormBase description: Zinc finger, C3HC4 type (RING finger)
F26F4.10 F26F4.10 P W All gene names: rrt-1; F26F4.10; 3G4; CE29495; CE37225; CE40950; WBGene00004679; WP:CE29495; WP:CE37225; WP:CE40950 WormBase description: rrt-1 encodes an arginyl-tRNA synthetase that affects embryonic viability and fertility
F26F4.5 F26F4.5 P W All gene names: F26F4.5; 3F978; CE29289; Q19816_CAEEL; WBGene00017827; WP:CE29289
F26F4.9 F26F4.9 P W All gene names: F26F4.9; 3G0; CE29292; CE31918; WBGene00017829; WP:CE29292; WP:CE31918 WormBase description: ankyrin and desmoplakin repeat regions
F27C1.6 F27C1.6 P W All gene names: F27C1.6; 1F990; CE09718; P91280_CAEEL; WBGene00017855; WP:CE09718
F27D4.5 F27D4.5 P W All gene names: tag-173; F27D4.5; 1I305; CE05736; Q93619_CAEEL; WBGene00006518; WP:CE05736 WormBase description: tag-173/F27D4.5 is orthologous to the human gene BRANCHED CHAIN KETO ACID DEHYDROGENASE E1, ALPHA POLYPEPTIDE (BCKDHB; OMIM:248600), which when mutated leads to maple syrup urine disease, type 1a; F27D4.5 protein is predicted to be mitochondrial. WormBase CDS description: 2-oxoisovalerate dehydrogenase
F28B3.6 F28B3.6 P W All gene names: F28B3.6; 1F520; CE33384; WBGene00017887; WP:CE33384
F28F8.6 F28F8.6 P W All gene names: atx-3; tag-70; F28F8.6; 5Q56; ATX3_CAEEL; CE09760; NM_074472; WBGene00006446; WP:CE09760 WormBase description: tag-70/F28F8.6 encodes an ortholog of human ATAXIN-3 (OMIM:607047, mutated in Machado-Joseph disease). WormBase CDS description: Human Machedo-Joseph disease protein 1 like
F29B9.4 F29B9.4 P W All gene names: psr-1; tag-159; F29B9.4; 4F419; CE27146; CE39926; NM_068205; PTDSR_CAEEL; WBGene00004205; WP:CE27146; WP:CE39926 WormBase description: psr-1 encodes an ortholog of the mammalian apoptotic phosphatidylserine receptor, whose product recognizes phosphatidylserine on apoptotic cells and enables cells expressing the receptor to recognize and engulf apoptotic cells in a phosphatidylserine-specific manner; psr-1 was not mutated in classical screens for Ced mutants, but, given its high similarity, may nevertheless mediate phosphatidylserine recognition on apoptotic cells during their removal by phagocytes.
F29C4.6 F29C4.6 P W All gene names: F29C4.6; 4A872; CE17723; WBGene00017928; WP:CE17723
F30A10.3 F30A10.3 P W All gene names: F30A10.3; 1K70; CE32396; WBGene00009262; WP:CE32396
F30F8.8 F30F8.8 P W All gene names: taf-5; F30F8.8; 1I429; CE39361; NM_059768; WBGene00006386; WP:CE39361 WormBase description: guanine nucleotide-binding protein
F30F8.9 F30F8.9 P W All gene names: F30F8.9; 1I415; CE27148; CE32398; WBGene00009276; WP:CE27148; WP:CE32398
F31C3.1 F31C3.1 P W All gene names: cyn-5; cyp-5; F31C3.1; 1P632; CE17730; NM_061223; WBGene00000881; WP:CE17730 WormBase description: cyp-5 encodes a cyclophilin that is functional in vitro and is predicted to be a secreted protein that is structurally most similar to human cyclophilin B; expressed in the intestine. WormBase CDS description: cyclophillin
F31D4.1 F31D4.1 P W All gene names: F31D4.1; 5V311; CE31921; WBGene00009289; WP:CE31921
F33A8.4 F33A8.4 P W All gene names: F33A8.4; CE17756; NM_063967; WBGene00009352; WP:CE17756
F33D11.10 F33D11.10 P W All gene names: F33D11.10; 1G444; CE09901; WBGene00018007; WP:CE09901 WormBase description: intiation factor/helicase
F33D4.5 F33D4.5 P W All gene names: F33D4.5; 4I472; CE29308; WBGene00017997; WP:CE29308
F33G12.3 F33G12.3 P W All gene names: F33G12.3; 2F322; CE04481; WBGene00018015; WP:CE04481
F33G12.4 F33G12.4 P W All gene names: F33G12.4; 2F326; CE27150; WBGene00018016; WP:CE27150
F35G12.12 F35G12.12 P W All gene names: F35G12.12; 3F673; CE31499; WBGene00009445; WP:CE31499
F35H12.5 F35H12.5 P W All gene names: F35H12.5; CE29791; CE34304; WBGene00018077; WP:CE29791; WP:CE34304; XB537
F36D4.3 F36D4.3 P W All gene names: hum-2; F36D4.3; 5J879; CE30777; CE33076; CE33077; CE35927; CE35928; NM_073032; Q8MYQ0_CAEEL; WBGene00002036; WP:CE30777; WP:CE33076; WP:CE33077; WP:CE35927; WP:CE35928 WormBase description: hum-2 is orthologous to the human gene MYOSIN HEAVY CHAIN 12 (MYO5A; OMIM:160777), which when mutated leads to disease.
F36F2.3 F36F2.3 P W All gene names: tag-214; F36F2.3; 1J586; CE34550; CE39152; WBGene00009477; WP:CE34550; WP:CE39152 WormBase description: Zinc finger, C3HC4 type (RING finger), Zinc finger, CCHC class
F36F2.4 F36F2.4 P W All gene names: syn-13; F36F2.4; 1J578; CE40328; O62236_CAEEL; WBGene00009478; WP:CE40328 WormBase description: Syntaxin
F37A4.1 F37A4.1 P W All gene names: F37A4.1; 3H813; CE00711; WBGene00018131; WP:CE00711
F37B12.2 F37B12.2 P W All gene names: gcs-1; F37B12.2; 2J326; CE32886; GSH1_CAEEL; NM_063526; WBGene00001527; WP:CE32886 WormBase description: gcs-1 encodes the C. elegans ortholog of gamma-glutamine cysteine synthetase heavy chain (GCS(h)); GCS-1 is predicted to function, in a conserved oxidative stress response pathway, as a phase II detoxification enzyme that catalyzes the rate-limiting first step in glutathione biosynthesis; a GCS-1::GFP reporter fusion is expressed in larvae and adults in the pharynx, ASI chemosensory neurons, and anterior and posterior intestine and upon exposure to oxidative stress, such as heat or herbicide, the intestinal expression increases dramatically; constitutive and stress-inducible GCS-1::GFP expression in the ASI neurons and intestine, respectively, is under the control of the SKN-1 CNC transcription factor; loss of gcs-1 activity via RNAi results in a low percentage of larval lethality and intestinal abnormalities suggesting that gcs-1 plays a role in postembryonic development. WormBase CDS description: glutamate-cysteine ligase
F37C12.13 F37C12.13 P W All gene names: F37C12.13; 3I286; CE26424; CE30780; WBGene00018154; WP:CE26424; WP:CE30780
F37C12.3 F37C12.3 P W All gene names: F37C12.3; 3I273; CE33082; WBGene00018151; WP:CE33082
F37D6.2 F37D6.2 P W All gene names: F37D6.2; 1L52; CE05819; CE29592; CE40957; WBGene00009508; WP:CE05819; WP:CE29592; WP:CE40957 WormBase description: Zinc finger, C2H2 type (2 domains)
F38A5.1 F38A5.1 P W All gene names: F38A5.1; 4H346; CE10028; CE33641; WBGene00018160; WP:CE10028; WP:CE33641
F39H2.2 F39H2.2 P W All gene names: cyn-14; cyp-14; sig-7; F39H2.2; 1J227; CE32410; CE32411; NM_059942; NM_182005; WBGene00000890; WP:CE32410; WP:CE32411 WormBase description: cyp-14 encodes a predicted cyclophilin. WormBase CDS description: peptidylprolyl isomerase
F41G3.6 F41G3.6 P W All gene names: F41G3.6; 2H35; CE28933; WBGene00018302; WP:CE28933
F41H10.11 F41H10.11 P W All gene names: sand-1; F41H10.11; 4G133; CE31693; WBGene00018321; WP:CE31693
F42C5.8 F42C5.8 P W All gene names: rps-8; F42C5.8; 4I78; CE04561; NM_068766; WBGene00004477; WP:CE04561 WormBase description: rps-8 encodes a small ribosomal subunit S8 protein; by homology, RPS-8 is predicted to function in protein biosynthesis; in C. elegans, RPS-8 activity is required for germline development and the overall health of the animal. WormBase CDS description: 40S ribosomal protein S8
F42G8.4 F42G8.4 P W All gene names: pmk-3; F42G8.4; 4I907; CE29318; NM_068962; PMK3_CAEEL; WBGene00004057; WP:CE29318 WormBase description: pmk-3 encodes a homolog of p38, a mitogen-activated protein kinase (MAPK), activated in vitro by MEK6, indicating that it does respond like p38 to physiological stress; PMK-3 is expressed in nuclei throughout the intestine; PMK-3 is activated by osmotic stresses when heterologously expressed in mammalian cells; null mutants do not exhibit observable growth defects or hypersensitivity to several tested known stresses. WormBase CDS description: protein kinase
F43E2.8 F43E2.8 P W All gene names: hsp-4; F43E2.8; 2H640; CE07244; NM_063135; WBGene00002008; WP:CE07244 WormBase description: hsp-4 encodes a predicted homolog of the mammalian ER chaperone BiP that affects embryonic and larval viability; expression is most prominent in the spermatheca and transcription of hsp-4 is induced in the gut and in the hypodermis upon ER stress. WormBase CDS description: heat shock protein
F43G9.13 F43G9.13 P W All gene names: F43G9.13; 1J183; CE27163; WBGene00009673; WP:CE27163
F44B9.5 F44B9.5 P W All gene names: F44B9.5; 3J104; CE24973; WBGene00018408; WP:CE24973
F44C8.4 F44C8.4 P W All gene names: nhr-103; F44C8.4; 5C705; CE27384; NM_071206; WBGene00003693; WP:CE27384 WormBase description: nhr-103 encodes a member of the superfamily of nuclear receptors, which is one of the most abundant class of transcriptional regulators; nuclear receptors have a well conserved DNA binding domain and a less conserved C-terminal ligand binding domain. WormBase CDS description: nulcear hormone receptor
F44E5.1 F44E5.1 P W All gene names: F44E5.1; 2M64; CE18676; WBGene00009688; WP:CE18676
F44G4.1 F44G4.1 P W All gene names: F44G4.1; 2J285; CE28332; WBGene00009711; WP:CE28332
F44G4.2 F44G4.2 P W All gene names: F44G4.2; 2J287; CE02229; WBGene00009712; WP:CE02229
F45G2.8 F45G2.8 P W All gene names: F45G2.8; 3O524; CE16051; WBGene00009734; WP:CE16051
F45H11.5 F45H11.5 P W All gene names: F45H11.5; 1K959; CE27165; WBGene00009745; WP:CE27165
F46A9.5 F46A9.5 P W All gene names: skr-1; F46A9.5; 1K49; CE10580; NM_060112; Q93647_CAEEL; WBGene00004807; WP:CE10580 WormBase description: The skr-1 gene encodes a homolog of Skp1 in S. cerevisiae that is required for the restraint of cell proliferation, progression through the pachytene stage of meiosis, and the formation of bivalent chromosomes at diakinesis. WormBase CDS description: cyclin A/CDK2-associated protein P19 like
F46B6.3 F46B6.3 P W All gene names: mab-14; smg-4; F46B6.3; 5K256; CE26973; CE30440; NM_171514; NM_171515; WBGene00004882; WP:CE26973; WP:CE30440
F46B6.5 F46B6.5 P W All gene names: F46B6.5; 5K260; CE33788; CE33789; CE34023; WBGene00009770; WP:CE33788; WP:CE33789; WP:CE34023
F46B6.6 F46B6.6 P W All gene names: F46B6.6; 5K264; CE26974; WBGene00009771; WP:CE26974 WormBase description: initiation factor IF-2
F46E10.8 F46E10.8 P W All gene names: ubh-1; F46E10.8; 5G990; CE20818; NM_072253; WBGene00006721; WP:CE20818 WormBase description: ubh-1 encodes a putative ubiquitin C-terminal hydrolase orthologous to human UCHL1 (OMIM:191342, mutated in Parkinson disease). WormBase CDS description: ubiquitin carboxyl-terminal hydrolase
F46F11.5 F46F11.5 P W All gene names: vha-10; F46F11.5; 1G178; CE10604; NM_059240; VATG_CAEEL; WBGene00006919; WP:CE10604 WormBase description: vha-10 encodes an ortholog of subunit G of the cytoplasmic (V1) domain of vacuolar proton-translocating ATPase (V-ATPase); VHA-10 is required for necrosis, since vha-10(RNAi) suppresses necrotic neurodegeneration and thapsigargin-induced cell death; VHA-10 is a predicted cytosolic stator (stalk) component. WormBase CDS description: vacuolar ATPase G subunit
F47B10.7 F47B10.7 P W All gene names: acbp-3; F47B10.7; CE32423; NM_077421; WBGene00009818; WP:CE32423; XL523 WormBase description: acyl-CoA-binding protein
F48E8.3 F48E8.3 P W All gene names: F48E8.3; 3G553; CE36546; WBGene00018610; WP:CE36546 WormBase description: fumarate reductase flavoprotein
F52B11.1 F52B11.1 P W All gene names: F52B11.1; 4O847; CE33791; CE33792; WBGene00009924; WP:CE33791; WP:CE33792
F52B5.2 F52B5.2 P W All gene names: F52B5.2; 1I892; CE24993; WBGene00009921; WP:CE24993 WormBase description: serine/threonine kinase (2 domains)
F52C12.1 F52C12.1 P W All gene names: F52C12.1; 4C727; CE19434; WBGene00018678; WP:CE19434
F53A2.6 F53A2.6 P W All gene names: ife-1; F53A2.6; 3O433; CE31809; IF4E1_CAEEL; NM_067350; WBGene00002059; WP:CE31809 WormBase description: The ife-1 gene encodes one of five C. elegans homologs of the mRNA cap-binding protein eIF4E; it is specifically required for spermatogenesis, and is expressed in P granules. WormBase CDS description: EUKARYOTIC TRANSLATION INITIATION FACTOR 4E (EIF-4E) (EIF4E) (MRNA CAP-BINDING PROTEIN) (EIF-4F 25 KD SUBUNIT)
F53A2.7 F53A2.7 P W All gene names: F53A2.7; 3O435; CE10878; WBGene00009952; WP:CE10878 WormBase description: Thiolases
F53A2.8 F53A2.8 P W All gene names: cup-6; mtm-6; F53A2.8; 3O443; CE16100; CE32050; CE37116; NM_067352; NM_181951; WBGene00003478; WP:CE16100; WP:CE32050; WP:CE37116 WormBase description: mtm-6 encodes a myotubularin-related protein that regulates phosphoinositide 3-phosphate localization and/or levels in vivo and mutation blocks endocytosis by coelomocytes; the MTM-6A isoform, which rescues the endocytic defect of mtm-6 mutants, is believed to function as part of a complex with MTM-9 and MTM-6A is predominantly localized to the coelomocyte cytoplasm, with some localization to the coelomocyte membrane.
F53B3.5 F53B3.5 P W All gene names: F53B3.5; CE30142; WBGene00018743; WP:CE30142; XD492 WormBase description: F53B3.5 encodes a claudin homolog that may regulate ion channels; F53B3.5 is distantly similar to mammalian voltage-dependent calcium channel gamma subunits that are known or suspected to prevent epilepsy in vivo (e.g., stargazin; MGI:1316660); F53B3.5 has no obvious function in mass RNAi assays; claudins are integral membrane proteins with four transmembrane sequences that are found in mammalian tight junctions (TJs), induce TJs when transgenically expressed in cells normally lacking them, and can mediate the specific conductance of of specific ions (e.g., magnesium or calcium) through TJs while blocking the flow of water.
F53C11.7 F53C11.7 P W All gene names: swan-2; tag-206; F53C11.7; 5O282; CE24997; WBGene00009976; WP:CE24997 WormBase description: Yeast hypothetical protein YPL247C like
F53C3.3 F53C3.3 P W All gene names: F53C3.3; 2E195; CE35939; WBGene00018747; WP:CE35939
F53F10.4 F53F10.4 P W All gene names: rab-2; unc-108; F53F10.4; 1E393; CE10986; NM_058832; WBGene00006833; WP:CE10986 WormBase description: unc-108 encodes a small GTPase homologous to the Rab GTPases that function in endocytosis, membrane fusion, and vesicular trafficking events; the precise biological role and expression pattern of unc-108 are not yet known. WormBase CDS description: RAS-related protein
F53F4.11 F53F4.11 P W All gene names: F53F4.11; 5O104; CE20849; WBGene00009993; WP:CE20849
F53F4.14 F53F4.14 P W All gene names: F53F4.14; 5O109; CE29593; WBGene00009996; WP:CE29593
F54C4.2 F54C4.2 P W All gene names: spt-4; F54C4.2; 3A686; CE19891; NM_064734; WBGene00005014; WP:CE19891
F54C8.3 F54C8.3 P W All gene names: apc-4; emb-30; F54C8.3; 3K526; CE32676; EMB30_CAEEL; NM_066673; WBGene00001284; WP:CE32676 WormBase description: emb-30 encodes an anaphase-promoting complex/cyclosome (APC/C) component orthologous to mammalian APC-4 and Schizosaccharomyces pombe Lid1; EMB-30 is required for the metaphase-to-anaphase transition during meiosis and mitosis, for establishing anterior-posterior polarity in the early embryo, and for proper localization of germline granules and the maternally provided PAR-2 and PAR-3 proteins.
F54C8.7 F54C8.7 P W All gene names: F54C8.7; 3K542; CE28833; CE33524; WBGene00010040; WP:CE28833; WP:CE33524
F54C9.10 F54C9.10 P W All gene names: arl-1; F54C9.10; 2I873; CE02250; NM_063415; WBGene00000187; WP:CE02250 WormBase description: arl-1 encodes a member of the GTP-binding ADP-ribosylation factor family. WormBase CDS description: GTP-binding ADP-ribosylation factor
F54D5.12 F54D5.12 P W All gene names: F54D5.12; 2L830; CE26814; WBGene00010055; WP:CE26814 WormBase description: yeast hyothetical YET1 like protein
F54D5.7 F54D5.7 P W All gene names: F54D5.7; CE03411; GCDH_CAEEL; NM_064068; WBGene00010052; WP:CE03411 WormBase description: The F54D5.7 gene encodes an ortholog of the human gene GLUTARYL-COENZYME A DEHYDROGENASE (GCDH), which when mutated leads to glutaricaciduria type I (OMIM:231670). WormBase CDS description: acyl-CoA dehydrogenase
F55A12.2 F55A12.2 P W All gene names: F55A12.2; 1F933; CE29396; CE30540; CE34317; CE34318; WBGene00018863; WP:CE29396; WP:CE30540; WP:CE34317; WP:CE34318
F55A3.1 F55A3.1 P W All gene names: marc-6; F55A3.1; 1L381; CE37022; WBGene00018847; WP:CE37022
F55B12.4 F55B12.4 P W All gene names: F55B12.4; CE26815; WBGene00010089; WP:CE26815 WormBase description: poly(A) polymerase like
F55D10.2 F55D10.2 P W All gene names: rpl-25.1; F55D10.2; CE02777; NM_076407; WBGene00004438; WP:CE02777; XF335 WormBase description: rpl-25.1 encodes a large ribosomal subunit L23a protein. WormBase CDS description: Ribosomal protein L23
F55F8.2 F55F8.2 P W All gene names: F55F8.2; 1G216; CE11190; CE33400; WBGene00018890; WP:CE11190; WP:CE33400 WormBase description: RNA helicase
F55F8.4 F55F8.4 P W All gene names: cir-1; tag-326; F55F8.4; 1G222; CE11194; WBGene00018892; WP:CE11194
F55H2.7 F55H2.7 P W All gene names: F55H2.7; 3K604; CE34033; WBGene00010132; WP:CE34033 WormBase description: F55H2.7 encodes an unfamiliar protein that is dispensable for viability and gross morphology in mass RNAi screens; it residues in a common operon with clu-1, and thus might act in concert with it.
F56A3.2 F56A3.2 P W All gene names: F56A3.2; 1F753; CE11216; WBGene00018909; WP:CE11216
F56A6.4 F56A6.4 P W All gene names: F56A6.4; 1B88; CE34319; WBGene00018923; WP:CE34319
F56A8.3 F56A8.3 P W All gene names: F56A8.3; 3O351; CE16123; CE28340; WBGene00010139; WP:CE16123; WP:CE28340 WormBase description: Leucine Rich Repeat (2 copies) (2 domains)
F56A8.4 F56A8.4 P W All gene names: F56A8.4; 3O353; CE16124; WBGene00010140; WP:CE16124
F56A8.6 F56A8.6 P W All gene names: cpf-2; F56A8.6; 3O356; CE16126; NM_067333; O45577_CAEEL; WBGene00000774; WP:CE16126 WormBase description: RNA recognition motif. (aka RRM, RBD, or RNP domain)
F56B3.4 F56B3.4 P W All gene names: skr-18; F56B3.4; 4B540; CE29969; CE37243; WBGene00004824; WP:CE29969; WP:CE37243 WormBase description: skr-18 encodes a homolog of Skp1 in S. cerevisiae, a core component of the SCF (Skp1p, Cullin, F-box) ubiquitin-ligase complex that facilitates ubiquitin-mediated protein degradation; SKR-18 has no known function in vivo, since skr-18(RNAi) animals are at least superficially normal.
F56C9.9 F56C9.9 P W
F56D2.7 F56D2.7 P W All gene names: ced-6; F56D2.7; 3G687; CE33657; NM_065802; WBGene00000420; WP:CE33657 WormBase description: ced-6 encodes an Src homology (SH) 3 and phosphotyrosine-binding (PTB) domain-containing adaptor protein, orthologous to human CED-6/GULP, that is required for cell corpse engulfment during apoptosis; CED-6 is bound by the phosphotyrosine binding motif in the cytoplasmic tail of the transmembrane protein CED-1, and and within phagocytic cells this interaction may be part of a signal transduction pathway that promotes apoptotic cell engulfment.
F56G4.5 F56G4.5 P W All gene names: bam-1; png-1; F56G4.5; 1L979; CE23786; NGLY1_CAEEL; WBGene00010160; WP:CE23786 WormBase description: Thioredoxins
F56H1.4 F56H1.4 P W All gene names: rpt-5; F56H1.4; 1G318; CE17915; NM_059271; WBGene00004505; WP:CE17915 WormBase description: rpt-5 encodes a triple A ATPase subunit of the 26S proteasome's 19S regulatory particle (RP) base subcomplex; RPT-5 is required for embryonic, larval, and germline development and by homology, is predicted to function in unfolding protein substrates and translocating them into the core proteolytic particle (CP) of the proteasome. WormBase CDS description: ATPase
F57B9.4 F57B9.4 P W All gene names: coq-2; F57B9.4; 3I27; CE28469; CE28470; CE32444; CE32445; CE32446; NM_066111; NM_066112; NM_181953; NM_181954; WBGene00000762; WP:CE28469; WP:CE28470; WP:CE32444; WP:CE32445; WP:CE32446 WormBase description: coq-2 encodes a putative para-hydroxybenzoate-polyprenyl transferase (UbiA prenyltransferase), orthologous to S. cerevisiae COQ2; COQ-2 is required for ubiquinone (coenzyme Q9) biosynthesis and for normally short lifespan; coq-2 mutants have slowed pharyngeal pumping, and eventually arrest as paralysed larvae before dying; coq-2(RNAi) animals have reduced levels of coenzyme Q9 and superoxide, and have abnormally long lifespans; coq-2 mutants are not rescued by dietary coenzyme Q.
F57B9.5 F57B9.5 P W All gene names: byn-1; F57B9.5; 3I25; CE25013; NM_066109; WBGene00000276; WP:CE25013 WormBase description: byn-1 encodes a homolog of mammalian BYSTIN-LIKE (BYSL; OMIM:603871).
F57C9.4 F57C9.4 P W All gene names: F57C9.4; 1F403; CE28474; CE28475; CE40970; Q95R06_CAEEL; WBGene00019011; WP:CE28474; WP:CE28475; WP:CE40970
F58A4.8 F58A4.8 P W All gene names: sas-3; tbg-1; F58A4.8; 3K716; CE00224; NM_066730; TBG_CAEEL; TUBG; WBGene00006540; WP:CE00224 WormBase description: tbg-1 encodes gamma-tubulin; in C. elegans, tbg-1 activity is essential and is required for normal bipolar spindle assembly and function, as well as the fast phase of female pronuclear migration following fertilization; while tbg-1 is required for proper organization and function of kinetochore and interpolar microtubules, it does not appear to be absolutely required for microtubule nucleation and growth; TBG-1 localizes to centrosomes in both interphase and mitotic cells, exhibiting a dynamic behavior during mitosis that differs between anterior and posterior centrosomes. WormBase CDS description: Gamma-like tubulin
F58B3.4 F58B3.4 P W All gene names: F58B3.4; 4M394; CE36170; WBGene00010231; WP:CE36170
F58B3.7 F58B3.7 P W All gene names: F58B3.7; 4M403; CE06009; WBGene00010233; WP:CE06009 WormBase description: Arabidopsis DNA-damage-repair protein D11 like
F58B6.3 F58B6.3 P W All gene names: par-2; F58B6.3; 3C183; CE25917; CE39258; NM_064931; WBGene00003917; WP:CE25917; WP:CE39258 WormBase description: par-2 encodes a protein containing a C3HC4-type RING-finger, a specialized type of zinc-finger found in E3 ubiquitin ligase subunits; PAR-2 is required maternally for polarization of the C. elegans zygote along the anterior-posterior (A-P) axis and is asymmetrically localized to the posterior cortex of the one- and two-cell embryo via interdependent interactions with PAR-3, PAR-6, and PKC-3.
F58G1.2 F58G1.2 P W All gene names: F58G1.2; 2N206; CE35561; WBGene00010264; WP:CE35561 WormBase description: Zinc finger, C2H2 type (6 domains)
F58G6.3 F58G6.3 P W All gene names: F58G6.3; 4K417; CE28937; WBGene00010274; WP:CE28937
F59A2.4 F59A2.4 P W All gene names: F59A2.4; 3E489; CE17941; CE39740; WBGene00010304; WP:CE17941; WP:CE39740; YMI4_CAEEL
F59C6.5 F59C6.5 P W All gene names: F59C6.5; 1L97; CE11464; Q93831_CAEEL; WBGene00010326; WP:CE11464 WormBase description: NADH ubiquinone oxidoreductase
F59E12.13 F59E12.13 P W All gene names: fut-3; tag-8; F59E12.13; 2F948; CE29413; NM_062705; O01906_CAEEL; WBGene00006402; WP:CE29413
F59G1.1 F59G1.1 P W All gene names: cgt-3; F59G1.1; 2G205; CE29810; CE29811; CE30378; CE33409; WBGene00019127; WP:CE29810; WP:CE29811; WP:CE30378; WP:CE33409
F59G1.7 F59G1.7 P W All gene names: frh-1; F59G1.7; 2G207; CE19476; NM_062782; WBGene00001486; WP:CE19476 WormBase description: frh-1 encodes the C. elegans frataxin ortholog;, by homology, FRH-1 is predicted to be a mitochondrial protein required for biogenesis of iron-sulfur clusters, co-factors necessary for proper function of electron transport chain proteins; in C. elegans, loss of frh-1 activity via RNAi results in small body size, pale coloration, reduced egg-laying and fertility, altered responses to oxidative stress, and a significant lifespan extension.
H06I04.1 H06I04.1 P W All gene names: H06I04.1; 3E189; CE29971; CE31020; CE31021; Q9N5N7_CAEEL; WBGene00019167; WP:CE29971; WP:CE31020; WP:CE31021
H14A12.2 H14A12.2 P W All gene names: fum-1; H14A12.2; 3I555; CE11580; CE32457; FUMH_CAEEL; NM_066241; NM_181944; WBGene00001503; WP:CE11580; WP:CE32457 WormBase description: fum-1 is orthologous to human FUMARASE (FH; OMIM:136850), which when mutated leads to fumarase deficiency; FUM-1A and FUM-1B are predicted to be mitochondrial.
H19N07.3 H19N07.3 P W All gene names: H19N07.3; 5L598; CE16184; WBGene00010407; WP:CE16184
H19N07.4 H19N07.4 P W All gene names: H19N07.4; 5L600; CE16185; WBGene00010408; WP:CE16185 WormBase description: H19N07.4 encodes an integral membrane protein with acyl-CoA:diacylglycerol o-acyltransferase activity when expressed in yeast; H19N07.4 belongs to the MBOAT protein family, whose biochemically characterized members transfer fatty acids or acetate to membrane-associated hydroxyl-bearing substrates such as cholesterol, diacylglycerol, long-chain alcohols, or alginate; MBOAT proteins include MOM-1 and its Drosophila homolog PORCUPINE, involved in Wnt signalling; H19N07.4 has no obvious function in mass RNAi assays.
H28G03.1 H28G03.1 P W All gene names: H28G03.1; CE30079; CE30080; CE31190; WBGene00019249; WP:CE30079; WP:CE30080; WP:CE31190; XF837 WormBase description: RNA binding protein
JC8.2 JC8.2 P W All gene names: JC8.2; 4N998; CE37529; WBGene00010435; WP:CE37529
K02B12.7 K02B12.7 P W All gene names: K02B12.7; 1J104; CE11618; WBGene00010500; WP:CE11618 WormBase description: ADP-ribosylation factor 1-directed GTPase activating protein
K02F3.12 K02F3.12 P W All gene names: K02F3.12; 3B477; CE33668; CE38084; WBGene00019334; WP:CE33668; WP:CE38084
K03B8.9 K03B8.9 P W All gene names: deg-3; K03B8.9; 5L894; CE06083; NM_073496; WBGene00000951; WP:CE06083 WormBase description: deg-3 encodes an alpha subunit of a nicotinic acetylcholine receptor (nAChR); originally defined by a gain-of-function mutation that results in neuronal degeneration and uncoordinated movement, DEG-3 can form heteromeric channels with a second alpha subunit, DES-2, and in vivo these channels appear to be required for chemosensation of choline; deg-3 and des-2 reside in an operon, and consistent with their role in metabolite chemosensation, are expressed in nonsynaptic regions such as the sensory endings of the IL2 chemosensory neurons; DEG-3 and DES-2 are also detected in the touch cell neurons, M1 head muscles, FLP and PVD sensory neurons, and the PVC interneuron; in subsets of these neurons, DEG-3 expression is not detectable in mec-3 or unc-86 mutant backgrounds. WormBase CDS description: nicotinic acetylcholine receptor
K04D7.2 K04D7.2 P W All gene names: K04D7.2; 4K943; CE28240; CE28241; MSP1_CAEEL; WBGene00010557; WP:CE28240; WP:CE28241 WormBase description: TAT binding homolog 4 like
K04G2.5 K04G2.5 P W All gene names: ath-1; K04G2.5; 1I614; CE27390; NM_059812; WBGene00010564; WP:CE27390 WormBase description: esterase
K04G7.4 K04G7.4 P W All gene names: nuo-4; K04G7.4; 3I246; CE01361; CE31031; WBGene00019401; WP:CE01361; WP:CE31031 WormBase description: NADH dehydrogenase
K05C4.1 K05C4.1 P W All gene names: pbs-5; K05C4.1; 1P310; CE19969; NM_061157; WBGene00003951; WP:CE19969 WormBase description: Proteasome A-type and B-type
K05C4.5 K05C4.5 P W All gene names: K05C4.5; 1P339; CE19973; WBGene00010582; WP:CE19973
K06H7.3 K06H7.3 P W All gene names: K06H7.3; 3J183; CE26941; NM_066364; WBGene00019457; WP:CE26941 WormBase description: Isopentenyl-diphosphate delta isomerase
K07A1.11 K07A1.11 P W All gene names: rba-1; K07A1.11; 1K194; CE11860; NM_060150; WBGene00004312; WP:CE11860 WormBase description: retinablastoma-binding protein RBAP46 like
K07A1.9 K07A1.9 P W All gene names: K07A1.9; 1K188; CE32465; CE32466; CE32467; WBGene00010615; WP:CE32465; WP:CE32466; WP:CE32467 WormBase description: arginyl-tRNA protein transferase like (truncated)
K07A12.1 K07A12.1 P W All gene names: K07A12.1; 1J245; CE18019; WBGene00010620; WP:CE18019
K07A12.4 K07A12.4 P W All gene names: K07A12.4; 1J264; CE39388; CE39389; WBGene00010622; WP:CE39388; WP:CE39389 WormBase description: elongation factor 1-alpha
K07C5.3 K07C5.3 P W All gene names: K07C5.3; 5K825; CE06113; WBGene00010626; WP:CE06113 WormBase description: DNA ligase like domain
K07F5.14 K07F5.14 P W All gene names: K07F5.14; 4K627; CE29594; WBGene00010638; WP:CE29594
K07G5.6 K07G5.6 P W All gene names: K07G5.6; 1H726; CE26899; WBGene00010645; WP:CE26899
K07H8.1 K07H8.1 P W All gene names: K07H8.1; 4J61; CE18021; WBGene00019503; WP:CE18021
K07H8.2 K07H8.2 P W All gene names: K07H8.2; 4J57; CE18022; CE28593; CE37721; WBGene00019504; WP:CE18022; WP:CE28593; WP:CE37721
K08D10.3 K08D10.3 P W All gene names: rnp-3; K08D10.3; 4E939; CE07355; NM_068104; WBGene00004386; WP:CE07355 WormBase description: U1 small nuclear ribonucleoprotein A
K08E3.8 K08E3.8 P W All gene names: mdt-29; K08E3.8; 3O867; CE18874; NM_067446; Q9XUS2_CAEEL; WBGene00007025; WP:CE18874 WormBase description: mdt-29 encodes a putative mediator subunit with a prion-like (asparagine- or glutamine-rich) domain; note that K08E3.8 is allegedly an ortholog of Drosophila INTERSEX/IX, but the actual C. elegans IX ortholog appears to be PQN-15); in yeast two-hybrid screens, MDT-29 interacts with SEL-7 and SEL-8; MDT-29 protein also self-associates; RNAi of K08E3.8 weakly enhances the two-anchor-cell phenotype of lin-12(ar170), roughly as much as sel-7 RNAi; since SEL-7 is a novel nuclear protein, MDT-29/SEL-7/SEL-8 is likely to form a nuclear complex formed in response to LIN-12 activation.
K08E7.1 K08E7.1 P W All gene names: K08E7.1; CE11920; NM_070004; WBGene00010671; WP:CE11920
K08F11.3 K08F11.3 P W All gene names: cif-1; K08F11.3; 4F472; CE11954; CSN7_CAEEL; WBGene00019543; WP:CE11954
K08F4.1 K08F4.1 P W All gene names: K08F4.1; 4K888; CE06149; WBGene00010676; WP:CE06149 WormBase description: Yeast Chl2p like
C27H6.8 K08H10.8 P W
K09E4.2 K09E4.2 P W All gene names: K09E4.2; 2O418; CE32691; WBGene00010720; WP:CE32691
K10B2.2 K10B2.2 P W All gene names: K10B2.2; 2G659; CE02009; CE33418; WBGene00019605; WP:CE02009; WP:CE33418 WormBase description: Carboxypeptidase
K10B3.7 K10B3.7 P W All gene names: gpd-3; K10B3.7; CE07370; NM_076133; WBGene00001685; WP:CE07370 WormBase description: gpd-3 encodes a predicted glyceraldehyde 3-phosphate dehydrogenase that affects embryonic viability; GPD-3 interacts with LIN-2 in two-hybrid assays.
K10C3.6 K10C3.6 P W All gene names: nhr-49; K10C3.6; 1K449; CE12084; CE28943; CE32693; CE32694; NM_060211; NM_060212; NM_181998; NM_181999; WBGene00003639; WP:CE12084; WP:CE28943; WP:CE32693; WP:CE32694 WormBase description: Ligand-binding domain of nuclear hormone receptors, Zinc finger, C4 type (two domains)
K11B4.1 K11B4.1 P W All gene names: K11B4.1; 1P387; CE29597; WBGene00010766; WP:CE29597
K11D12.7 K11D12.7 P W All gene names: K11D12.7; 5F514; CE28945; WBGene00019647; WP:CE28945
K11G12.5 K11G12.5 P W All gene names: K11G12.5; CE02827; WBGene00019656; WP:CE02827; XH342 WormBase description: mitochondrial 2-oxoglutartae
K11H12.1 K11H12.1 P W All gene names: K11H12.1; 4B404; CE12146; WBGene00019658; WP:CE12146 WormBase description: DNA-binding protein
K12H4.4 K12H4.4 P W All gene names: phi-20; K12H4.4; 3J133; CE00269; WBGene00019679; WP:CE00269 WormBase description: Signal peptidase
M01B12.3 M01B12.3 P W All gene names: arx-7; M01B12.3; 1D638; CE18061; NM_058698; WBGene00000205; WP:CE18061 WormBase description: arx-7 encodes the C. elegans ortholog of the p16Arc subunit of the actin-related protein (Arp)2/3 complex.
M01F1.2 M01F1.2 P W All gene names: rpl-16; M01F1.2; 3E592; CE01030; NM_065320; WBGene00004428; WP:CE01030 WormBase description: rpl-16 encodes a large ribosomal subunit L13a protein. WormBase CDS description: L13P family ribosomal protein
M01G5.3 M01G5.3 P W All gene names: M01G5.3; 3C600; CE29983; WBGene00019716; WP:CE29983
M03C11.2 M03C11.2 P W All gene names: M03C11.2; 3L490; CE03493; WBGene00010839; WP:CE03493 WormBase description: CHL1 protein
M03C11.5 M03C11.5 P W All gene names: ymel-1; M03C11.5; 3L509; CE03496; WBGene00010842; WP:CE03496 WormBase description: ATP-binding protein (AAA protein family member)
M03F8.2 M03F8.2 P W All gene names: pst-1; M03F8.2; 5G431; CE38399; CE38400; CE38401; NM_171463; NM_171464; WBGene00004206; WP:CE38399; WP:CE38400; WP:CE38401
M05D6.2 M05D6.2 P W All gene names: M05D6.2; 2I759; CE03500; WBGene00010875; WP:CE03500 WormBase description: testis-specific like protein
M18.3 M18.3 P W All gene names: M18.3; 4M871; CE06195; WBGene00010889; WP:CE06195
M18.8 M18.8 P W All gene names: M18.8; 4M891; CE32911; WBGene00010892; WP:CE32911
M28.6 M28.6 P W All gene names: lact-3; M28.6; 2K944; CE02284; WBGene00010897; WP:CE02284 WormBase description: esterase
M57.2 M57.2 P W All gene names: M57.2; 4E295; CE19541; WBGene00019778; WP:CE19541
M7.5 M7.5 P W All gene names: atg-7; atgr-7; M7.5; 4L844; CE18887; WBGene00010882; WP:CE18887 WormBase description: Yeast YHX1 like
R01B10.5 R01B10.5 P W All gene names: jamp-1; R01B10.5; 5G528; CE26750; WBGene00019807; WP:CE26750
R02D3.3 R02D3.3 P W All gene names: R02D3.3; 4A980; CE36601; WBGene00019821; WP:CE36601
R02F11.4 R02F11.4 P W All gene names: R02F11.4; 5F290; CE12502; O16366_CAEEL; WBGene00019842; WP:CE12502
R03A10.4 R03A10.4 P W All gene names: nkat-3; R03A10.4; CE29335; CE37983; WBGene00010984; WP:CE29335; WP:CE37983; XQ61 WormBase description: gluamine-phenylpyruvate transaminase
R03E1.2 R03E1.2 P W All gene names: R03E1.2; CE18902; WBGene00010993; WP:CE18902; XO782
R04F11.3 R04F11.3 P W All gene names: R04F11.3; 5M796; CE29598; WBGene00011016; WP:CE29598
R05D11.4 R05D11.4 P W All gene names: R05D11.4; 1J177; CE06239; WBGene00011032; WP:CE06239 WormBase description: ATP dependent RNA helicase
R05D11.5 R05D11.5 P W All gene names: R05D11.5; 1J169; CE27195; WBGene00011033; WP:CE27195
R05D11.9 R05D11.9 P W All gene names: R05D11.9; 1J171; CE32474; Q95ZR2_CAEEL; WBGene00011037; WP:CE32474
R05D3.6 R05D3.6 P W All gene names: R05D3.6; 3J440; CE00285; WBGene00019880; WP:CE00285 WormBase description: ATPase epsilon chain
R06C1.1 R06C1.1 P W All gene names: hda-3; R06C1.1; 1M506; CE18116; NM_060625; WBGene00001836; WP:CE18116 WormBase description: hda-3 encodes a member of the histone deacetylase family most similar to human histone deacetylase 1 (HD1) that affects radiation sensitivity. WormBase CDS description: Histone deacetylase family
R06C7.5 R06C7.5 P W All gene names: R06C7.5; 1H824; CE06248; CE32476; WBGene00011064; WP:CE06248; WP:CE32476 WormBase description: The R06C7.5 gene encodes an ortholog of the human gene ADSL, which when mutated leads to adenylosuccinate lyase deficiency (OMIM:103050).
R07E5.2 R07E5.2 P W All gene names: prdx-3; R07E5.2; 3F499; CE00657; NM_065491; WBGene00011110; WP:CE00657; ceprx1 WormBase description: Mer5 (mouse)
R07H5.1 R07H5.1 P W All gene names: prx-14; R07H5.1; 4L949; CE12550; NM_069696; Q93930_CAEEL; WBGene00004199; WP:CE12550
R09F10.3 R09F10.3 P W All gene names: R09F10.3; CE33810; WBGene00019987; WP:CE33810; XI913
R102.4 R102.4 P W All gene names: R102.4; 4L458; CE40367; CE40368; CE40369; WBGene00011291; WP:CE40367; WP:CE40368; WP:CE40369 WormBase description: Yeast GLY1 like
R107.4 R107.4 P W All gene names: ikke-1; R107.4; 3K136; CE31817; CE31818; CE31819; CE37846; WBGene00011299; WP:CE31817; WP:CE31818; WP:CE31819; WP:CE37846; YNH4_CAEEL WormBase description: tyrosine-protein kinase
R10E11.2 R10E11.2 P W All gene names: vha-2; R10E11.2; 3K875; CE06290; NM_066765; WBGene00006911; WP:CE06290 WormBase description: vha-2 and vha-3 encode an ortholog of subunit c of the membrane-bound (V0) domain of vacuolar proton-translocating ATPase (V-ATPase); the protein encoded by vha-2 and vha-3 (VHA-2/3) is identical; VHA-2/3 is a predicted V-ATPase transmembrane rotor component, whose polypeptide sequence is identical to that of VHA-3; VHA-1 and VHA-2/3 comprise a closely related family of subunit c co-orthologs, predicted to carry protons from the cytosol to a-subunits (VHA-5, VHA-6, VHA-7, or UNC-32) for transmembrane export; VHA-2/3 is dispensable for viability, since vha-2/3(RNAi) animals have mostly healthy progeny; however, VHA-2 is required for ovulation and embryogenesis, since vha-2(RNAi) animals are sterile with polyploid, unmatured oocytes; VHA-2, along with VHA-15 and probably all V-ATPase subunits, is required for systemic RNAi, probably during endocytotic RNAi uptake; VHA-2 is required for necrosis, since vha-2(RNAi) suppresses necrotic neurodegeneration; vha-2 shares an operon with vha-1 and R10E11.6; both vha-2 and vha-1 are expressed in the excretory cell, the rectum, and a pair of cells posterior to the anus. WormBase CDS description: Vacuolar ATP synthase subunit
R10H10.1 R10H10.1 P W All gene names: lpd-8; R10H10.1; 4L153; CE06292; NM_069516; WBGene00003064; WP:CE06292 WormBase description: lpd-8 encodes a homolog of human and mouse HIRA-interacting protein-5; LPD-8 has C-terminal similarity to a domain of NifU observed in thioredoxin-like proteins and domains (COG0694), and is predicted to be mitochondrial on phylogenetic grounds. WormBase CDS description: Yeast hypothetical protein YKE0 like
R119.3 R119.3 P W All gene names: R119.3; 1A848; CE28758; WBGene00020089; WP:CE28758 WormBase description: dehydrogenase
R11A8.4 R11A8.4 P W All gene names: sir-2.1; R11A8.4; 4L128; CE06302; NM_069511; SIRT1_CAEEL; WBGene00004800; WP:CE06302 WormBase description: sir-2.1 encodes a homolog of the S. cerevisiae gene SIR2. WormBase CDS description: Yeast regulatory protein SIR2 like
R11D1.1 R11D1.1 P W All gene names: R11D1.1; 5N187; CE38535; CE38536; Q21934_CAEEL; WBGene00011242; WP:CE38535; WP:CE38536 WormBase description: WD domain, G-beta repeat
R11E3.7 R11E3.7 P W All gene names: dpf-7; R11E3.7; 4F564; CE19549; CE31721; NM_171328; NM_171329; WBGene00001060; WP:CE19549; WP:CE31721
R11E3.8 R11E3.8 P W All gene names: dpf-5; R11E3.8; 4F568; CE29985; NM_068246; WBGene00001058; WP:CE29985 WormBase description: dpf-5 encodes a putative acylamino-acid-releasing enzyme (AARE; EC 18.104.22.168), orthologous to human APEH, with no obvious function in mass RNAi assays.
R12E2.1 R12E2.1 P W All gene names: R12E2.1; 1E751; CE18133; WBGene00020030; WP:CE18133
R12E2.4 R12E2.4 P W All gene names: inx-17; opu-17; R12E2.4; 1E733; CE18136; CE38537; INX17_CAEEL; NM_058914; WBGene00002139; WP:CE18136; WP:CE38537
R12H7.5 R12H7.5 P W All gene names: skr-20; R12H7.5; CE06317; NM_077791; WBGene00004826; WP:CE06317; XN840 WormBase description: The skr-20 gene encodes a homolog of Skp1 in S. cerevisiae that has no known function in vivo, since skr-20(RNAi) animals are at least superficially normal. WormBase CDS description: RNA polymerase II elongation factor like
R144.6 R144.6 P W All gene names: R144.6; 3G94; CE37549; WBGene00020096; WP:CE37549
R144.7 R144.7 P W All gene names: larp-1; R144.7; 3G102; CE31582; CE39272; NM_065663; WBGene00020097; WP:CE31582; WP:CE39272
R151.10 R151.10 P W All gene names: R151.10; 3I320; CE27198; WBGene00020113; WP:CE27198
R151.2 R151.2 P W All gene names: R151.2; 3I303; CE00745; CE29454; CE29987; CE37138; Q21994_CAEEL; WBGene00020107; WP:CE00745; WP:CE29454; WP:CE29987; WP:CE37138 WormBase description: R151.2 is orthologous to the human gene PHOSPHORIBOSYL PYROPHOSPHATE SYNTHETASE 1 (PRPS1; OMIM:311850), which when mutated leads to disease
R151.6 R151.6 P W All gene names: R151.6; 3I312; CE39620; DERL2_CAEEL; WBGene00020109; WP:CE39620
R151.7 R151.7 P W All gene names: R151.7; 3I314; CE39621; CE39622; WBGene00020110; WP:CE39621; WP:CE39622 WormBase description: HSP C62.5
R151.8 R151.8 P W All gene names: R151.8; 3I318; CE27201; WBGene00020111; WP:CE27201
R53.1 R53.1 P W All gene names: R53.1; CE02303; CE38215; WBGene00011271; WP:CE02303; WP:CE38215 WormBase description: FAD-1 like protein
T01C3.6 T01C3.6 P W All gene names: rps-16; T01C3.6; 5P480; CE12918; NM_074289; WBGene00004485; WP:CE12918 WormBase description: rps-16 encodes a small ribosomal subunit S16 protein. WormBase CDS description: 40S ribosomal protein S16
T01E8.4 T01E8.4 P W All gene names: T01E8.4; 2K528; CE02308; WBGene00011332; WP:CE02308 WormBase description: This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins; its encoded protein also contains WD repeats. WormBase CDS description: WD domain, G-beta repeats
T01E8.6 T01E8.6 P W All gene names: T01E8.6; 2K532; CE32923; WBGene00011334; WP:CE32923 WormBase description: mitochondrial ribosomal protein S14
T01G9.2 T01G9.2 P W All gene names: T01G9.2; 1I852; CE23937; CE27202; ORF1; U183_CAEEL; WBGene00011344; WP:CE23937; WP:CE27202
T01G9.4 T01G9.4 P W All gene names: kup-2; npp-2; T01G9.4; 1I868; CE06341; NM_059855; WBGene00003788; WP:CE06341 WormBase description: npp-2 encodes a protein with low similarity to rat nucleoporin Nup75 that affects embryonic viability and has a variety of other defects in RNAi screens including: nuclear morphology, growth, fertility, locomotion, and egg laying; enriched in oocytes.
T01H3.2 T01H3.2 P W All gene names: T01H3.2; 2I166; CE23938; WBGene00011348; WP:CE23938 WormBase description: T01H3.2 encodes a large (980-residue) uncharacterized protein, with multiple dysferlin and beta-propeller domains, that is conserved among metazoa; T01H3.2 shares an operon with vha-4, and thus might be a previously undescribed V-ATPase component or ancillary protein.
T02G5.7 T02G5.7 P W All gene names: T02G5.7; CE04859; NM_063055; WBGene00020166; WP:CE04859 WormBase description: The T02G5.7 gene encodes a homolog of the human gene ACAT1, which when mutated leads to alpha-methylacetoaceticaciduria (OMIM:203750). WormBase CDS description: acetoacetyl CoA thiolase
T02H6.1 T02H6.1 P W All gene names: T02H6.1; 2B13; CE23942; CE32061; WBGene00020171; WP:CE23942; WP:CE32061
T03D8.2 T03D8.2 P W All gene names: T03D8.2; 5V309; CE18920; WBGene00011391; WP:CE18920 WormBase description: Ribosomal protein S12
T04A8.7 T04A8.7 P W All gene names: T04A8.7; CE01076; CE33539; NM_065560; NM_181902; WBGene00011409; WP:CE01076; WP:CE33539 WormBase description: T04A8.7 is orthologous to human GLUCOSIDASE, ACID BETA (GBA; OMIM:606463), which when mutated leads to Gaucher disease.
T04C12.4 T04C12.4 P W All gene names: act-3; T04C12.4; 5L552; NM_073416; WBGene00000065; act1; act3 WormBase description: act-3 encodes an invertebrate actin, highly similar to ACT-1, ACT-2, and ACT-4, that functions in body wall muscle. WormBase CDS description: actin
T05E7.3 T05E7.3 P W All gene names: T05E7.3; 1G767; CE13235; WBGene00020259; WP:CE13235
T05G5.6 T05G5.6 P W All gene names: ech-6; T05G5.6; 3K842; CE00318; ECHM_CAEEL; NM_066755; WBGene00001155; WP:CE00318 WormBase description: Enoyl-CoA hydratase
T05H10.2 T05H10.2 P W All gene names: apn-1; T05H10.2; 2I339; CE28953; CeAPN1; NM_063286; WBGene00000151; WP:CE28953 WormBase description: apn-1 encodes a member of the AP (apurinic or apyrimidinic) endonuclease family. WormBase CDS description: AP endonuclease (family 2)
T05H10.6 T05H10.6 P W All gene names: T05H10.6; CE01643; CE32929; NM_063292; NM_182153; WBGene00011510; WP:CE01643; WP:CE32929 WormBase description: T05H10.6 encodes an ortholog of the human gene PYRUVATE DEHYDROGENASE (LIPOAMIDE) ALPHA 1 (PDHA1; OMIM:312170), which when mutated leads to Leigh syndrome (OMIM:256000); the T05H10.6 protein is predicted to be mitochondrial with 68% accuracy.
T05H4.11 T05H4.11 P W All gene names: T05H4.11; 5G904; CE27440; WBGene00020274; WP:CE27440
T05H4.12 T05H4.12 P W All gene names: atp-4; T05H4.12; 5G906; CE13291; WBGene00020275; WP:CE13291
T05H4.14 T05H4.14 P W All gene names: gad-1; tag-86; T05H4.14; 5G912; CE13295; NM_072234; O16519_CAEEL; WBGene00001513; WP:CE13295 WormBase description: The gad-1 gene encodes a WD repeat-containing protein that is required maternally for gastrulation initiation during early embryogenesis by regulating the division timing, spindle orientation, and subsequent inward migration of the two gut precusor (E) cells at the 26-cell stage.
T05H4.8 T05H4.8 P W All gene names: T05H4.8; 5G898; WBGene00020271
T06C12.6 T06C12.6 P W All gene names: nhr-102; T06C12.6; 5Q354; CE16356; NM_074566; WBGene00003692; WP:CE16356 WormBase description: Zinc finger, C4 type (two domains)
T06D8.5 T06D8.5 P W All gene names: T06D8.5; 2L522; CE02326; WBGene00011526; WP:CE02326 WormBase description: YER141W
T07D1.2 T07D1.2 P W All gene names: T07D1.2; CE29467; WBGene00020301; WP:CE29467; XD50
T07G12.10 T07G12.10 P W All gene names: zim-2; T07G12.10; 4L323; CE29521; WBGene00011600; WP:CE29521 WormBase description: Zinc finger, C2H2 type
T08B2.7 T08B2.7 P W All gene names: T08B2.7; 1G784; CE13431; CE26950; CE30299; WBGene00020347; WP:CE13431; WP:CE26950; WP:CE30299 WormBase description: T08B2.7 is orthologous to the human gene HYDROXYACYL-COENZYME A DEHYDROGENASE/3-KETOACYL-COENZYME A THIOLASE/ENOYL-COENZYME A HYDRATASE (TRIFUNCTIONAL PROTEIN), ALPHA SUBUNIT (HADHA; OMIM:600890), which when mutated leads to disease
T08G2.3 T08G2.3 P W All gene names: T08G2.3; CE07473; WBGene00020366; WP:CE07473; XR828 WormBase description: T08G2.3 is orthologous to the human gene ACYL-CoA DEHYDROGENASE, MEDIUM-CHAIN (ACADM; OMIM:607008), which when mutated leads to MCAD deficiency. WormBase CDS description: acyl-CoA dehydrogenase
T09A5.7 T09A5.7 P W All gene names: T09A5.7; 2I146; CE01088; WBGene00011635; WP:CE01088
T09A5.9 T09A5.9 P W All gene names: T09A5.9; 2I149; CE01090; WBGene00011637; WP:CE01090 WormBase description: SDS22 protein
T09B4.9 T09B4.9 P W All gene names: T09B4.9; 1G754; CE13473; TIM44_CAEEL; WBGene00020383; WP:CE13473
T09F3.4 T09F3.4 P W All gene names: T09F3.4; 2K687; CE35187; WBGene00011663; WP:CE35187
T10B11.2 T10B11.2 P W All gene names: T10B11.2; 1H511; CE18241; WBGene00020398; WP:CE18241
T10B5.5 T10B5.5 P W All gene names: T10B5.5; 5C353; CE28255; CE33316; WBGene00020391; WP:CE28255; WP:CE33316
T10C6.6 T10C6.6 P W All gene names: T10C6.6; 5Q507; CE16381; CE23965; WBGene00011688; WP:CE16381; WP:CE23965
T10E9.9 T10E9.9 P W All gene names: T10E9.9; 1H122; CE34367; WBGene00020419; WP:CE34367 WormBase description: acyl-CoA dehydrongenase
T10F2.1 T10F2.1 P W All gene names: grs-1; T10F2.1; 3G250; CE29472; CE32719; NM_065692; NM_181911; WBGene00001744; WP:CE29472; WP:CE32719 WormBase description: grs-1 encodes a member of the glycyl-tRNA synthetase family that affects embryonic viability and spindle maintenance during anaphase.
T10H9.3 T10H9.3 P W All gene names: T10H9.3; 5H134; CE18251; O76413_CAEEL; WBGene00020425; WP:CE18251
T11G6.8 T11G6.8 P W All gene names: T11G6.8; 4L627; CE33830; PX1; WBGene00011722; WP:CE33830 WormBase description: RNA recognition motif. (aka RRM, RBD, or RNP domain)
T12E12.1 T12E12.1 P W All gene names: T12E12.1; 4G323; CE31725; WBGene00020462; WP:CE31725
T13C5.5 T13C5.5 P W All gene names: bca-1; T13C5.5; CE04946; CE30453; NM_171700; NM_171701; WBGene00000245; WP:CE04946; WP:CE30453; XG820 WormBase description: bca-1 encodes a member of the carbonic anhydrase family.
T13F2.8 T13F2.8 P W All gene names: cav-1; T13F2.8; 4K537; CE13633; NM_069342; WBGene00000301; WP:CE13633 WormBase description: cav-1 encodes a member of the caveolin protein family that affects viability and Ras/MAP-kinase-dependent progression through the meiotic cell cycle meiotic; expressed in the adult germ line and during embryonic development. WormBase CDS description: caveolin
T14G10.1 T14G10.1 P W All gene names: pps-1; T14G10.1; 4K927; CE06447; NM_069456; WBGene00004091; WP:CE06447 WormBase description: pps-1 is orthologous to human PAPSS1 (OMIM:603262) and human PAPSS2 (OMIM:603005, mutated in spondyloepimetaphyseal dysplasia). WormBase CDS description: sulphate adenyltransferase
T14G10.7 T14G10.7 P W All gene names: T14G10.7; 4K912; CE06453; WBGene00011776; WP:CE06453
T16G1.11 T16G1.11 P W All gene names: eif-3.K; pqn-69; T16G1.11; 5N435; CE20081; NM_073840; WBGene00001233; WP:CE20081 WormBase description: The protein product of this gene was predicted to contain a glutamine/asparagine (Q/N)-rich ('prion') domain, by the algorithm of Michelitsch and Weissman (as of the WS72 release of WormBase, i.e., in wormpep77).
T16H12.4 T16H12.4 P W All gene names: T16H12.4; 3L178; CE29053; TF2H2_CAEEL; WBGene00011814; WP:CE29053 WormBase description: transcription factor IIH subunit
T19A6.3 T19A6.3 P W All gene names: T19A6.3; 1I977; CE28962; WBGene00011828; WP:CE28962
T19E7.2 T19E7.2 P W All gene names: skn-1; T19E7.2; 4G416; CE27591; CE31238; CE31239; NM_171345; NM_171346; NM_171347; SKN1_CAEEL; WBGene00004804; WP:CE27591; WP:CE31238; WP:CE31239 WormBase description: skn-1 encodes a transcription factor with similarity to the basic region of bZip transcription factors; during early embryogenesis, maternally provided SKN-1 is required for specification of the EMS blastomere, a mesendodermal precursor that gives rise to pharyngeal, muscle, and intestinal cells; later, during postembryonic development, SKN-1 functions in the p38 MAPK-mediated oxidative stress response pathway, as well as in regulation of lifespan; SKN-1 is detected at highest levels in nuclei of the P1 blastomere and its descendants through the 8-cell stage of embryogenesis; later in embryogenesis, SKN-1 is observed in all hypodermal and intestinal nuclei, with reporter constructs indicating that intestinal expression begins as early as the 50-100-cell stage; in larvae and young adults, SKN-1 reporters are expressed in the intestine and ASI neurons, with expression in intestinal nuclei greatly enhanced under stress-inducing conditions.
T20B12.7 T20B12.7 P W All gene names: T20B12.7; 3I468; CE01413; WBGene00020604; WP:CE01413
T20G5.2 T20G5.2 P W All gene names: cts-1; T20G5.2; 3L304; CE00513; NM_066863; WBGene00000833; WP:CE00513 WormBase description: cts-1 encodes a citrate synthase, predicted to be mitochondrial, that is required for embryonic development. WormBase CDS description: Citrate synthase
T20H4.4 T20H4.4 P W All gene names: adr-2; T20H4.4; 3I322; ADR2_CAEEL; CE25120; WBGene00000080; WP:CE25120 WormBase description: adr-2 encodes an adenosine deaminase that acts on RNA (ADAR); ADARs are RNA-editing enzymes that deaminate adenosines to create inosines in double-stranded RNA (dsRNA); adr-2 is expressed ubiquitously in early embryos, as well as in the germline of early adults; ADR-2 is required for ADAR activity in vivo, and for normal chemotaxis.
T21B10.1 T21B10.1 P W All gene names: T21B10.1; 2J221; CE03683; WBGene00011883; WP:CE03683
T21B10.2 T21B10.2 P W All gene names: enol-1; T21B10.2; 2J223; CE03684; CE32730; CE36954; WBGene00011884; WP:CE03684; WP:CE32730; WP:CE36954 WormBase description: T21B10.2 is orthologous to human ENOLASE 1 (also CRYSTALLIN, TAU; ENO1; OMIM:172430), which when mutated leads to spherocytic red cell enolase deficiency.
T22B11.5 T22B11.5 P W All gene names: T22B11.5; 4F462; CE28486; WBGene00020679; WP:CE28486 WormBase description: The T22B11.5 gene encodes an ortholog of the human gene OGDH, which when mutated leads to alpha-ketoglutarate deficiency (OMIM:203740); the T22B11.5 protein is predicted to be mitochondrial with 68% accuracy. WormBase CDS description: 2-oxoglutarate dehydrogenase
T22C1.3 T22C1.3 P W All gene names: T22C1.3; 1I515; CE39412; WBGene00011914; WP:CE39412 WormBase description: cell division control protein
T22D1.3 T22D1.3 P W All gene names: T22D1.3; 4H681; CE30188; CE33940; WBGene00020682; WP:CE30188; WP:CE33940 WormBase description: inosine monophosphate dehydrogenase
T23B12.3 T23B12.3 P W All gene names: T23B12.3; 5I947; CE14030; WBGene00020718; WP:CE14030 WormBase description: ribosomal protein
T23B12.6 T23B12.6 P W All gene names: T23B12.6; 5I938; CE14036; WBGene00020721; WP:CE14036
T23D8.3 T23D8.3 P W All gene names: T23D8.3; 1K550; CE14052; O02327_CAEEL; WBGene00011944; WP:CE14052
T23D8.7 T23D8.7 P W All gene names: T23D8.7; 1K569; CE14058; WBGene00011945; WP:CE14058
T23G11.5 T23G11.5 P W All gene names: rlbp-1; T23G11.5; 1I269; CE28965; WBGene00011970; WP:CE28965
T23G11.7 T23G11.7 P W All gene names: T23G11.7; 1I257; CE16459; CE32500; WBGene00011972; WP:CE16459; WP:CE32500
T23G7.2 T23G7.2 P W All gene names: T23G7.2; 2J458; CE35908; WBGene00011965; WP:CE35908
T24D1.2 T24D1.2 P W All gene names: T24D1.2; 1K530; CE29600; WBGene00011985; WP:CE29600 WormBase description: Zinc finger, C3HC4 type (RING finger) (2 domains)
T24F1.1 T24F1.1 P W All gene names: tag-29; T24F1.1; 2L593; CE02361; WBGene00006414; WP:CE02361 WormBase description: GTP-binding protein
T24F1.2 T24F1.2 P W All gene names: T24F1.2; 2L595; CE02362; Q22747_CAEEL; WBGene00011994; WP:CE02362
T25G3.3 T25G3.3 P W All gene names: T25G3.3; CE30306; NM_059713; WBGene00012030; WP:CE30306 WormBase description: Yeast nonsense-mediated mRNA decay protein like
T26A5.4 T26A5.4 P W All gene names: T26A5.4; 3H551; CE00701; WBGene00020820; WP:CE00701 WormBase description: Beta-mannosyltransferase
T26A5.6 T26A5.6 P W All gene names: T26A5.6; 3H538; CE29822; WBGene00020822; WP:CE29822
T26C11.6 T26C11.6 P W All gene names: ceh-21; T26C11.6; CE29823; NM_075940; WBGene00000444; WP:CE29823; XC468 WormBase description: ceh-21 encodes a a ONECUT class CUT homeobox protein with a single N-terminal cut domain and an OCAM domain; the cut domain may be a compact DNA-binding domain composed of alpha helices; the OCAM domain is a nematode-specific motif conserved between CEH-21, CEH-41, and T02B5.2; ceh-21 is one of three nematode-specific ONECUT genes in a cluster with ceh-39 and ceh-41; CEH-21 may be required for muscle formation and differentiation, and is expressed in muscle precursor cells and differentiated gut cells; ceh-21 has no obvious function in mass RNAi assays. WormBase CDS description: homeobox
T26C12.1 T26C12.1 P W All gene names: T26C12.1; 4E27; CE26009; WBGene00020831; WP:CE26009 WormBase description: acetolactate synthase
T26E3.3 T26E3.3 P W All gene names: par-6; T26E3.3; 1N265; CE28089; CE40130; NM_060807; PAR6_CAEEL; WBGene00003921; WP:CE28089; WP:CE40130 WormBase description: par-6 encodes a PDZ-domain-containing protein that is conserved in Drosophila and mammals; during development, maternally provided PAR-6 is required for establishing anterior-posterior polarity in the early C. elegans embryo; par-6 activity is also essential for determining proper apicobasal asymmetries associated with cell adhesion and gastrulation; PAR-6 localizes to the periphery of the newly fertilized embryo, and then becomes more prominent in the anterior periphery as well as the advancing cleavage furrow during the first mitosis; in germline precursors, PAR-6 localizes asymmetrically to sites that correspond to the future EMS and C blastomeres; in somatic cells, by the end of the four-cell stage, PAR-6 is seen as a 'cap' centered on the apical surface; in embryos, PAR-6 colocalizes with PAR-3 and is mutually dependent upon PAR-3 and PKC-3 for proper localization, suggesting that these proteins may act in a complex to establish embryonic polarity; PAR-6 localization is also dependent upon wild-type activity of par-4.
T27E9.4 T27E9.4 P W All gene names: kel-3; T27E9.4; 3O559; CE29824; CE29825; NM_067383; NM_067384; WBGene00002185; WP:CE29824; WP:CE29825 WormBase description: ring canal protein like
T27E9.7 T27E9.7 P W All gene names: T27E9.7; 3O548; CE18971; WBGene00012097; WP:CE18971 WormBase description: ABC transporters (2 domains)
T27F2.1 T27F2.1 P W All gene names: skp-1; T27F2.1; 5M129; CE06519; NM_073549; WBGene00004806; WP:CE06519; YGH1_CAEEL WormBase description: Drosophila puff specific protein BX42 like
T27F6.6 T27F6.6 P W All gene names: T27F6.6; 1N85; CE34214; WBGene00012105; WP:CE34214
T27F6.7 T27F6.7 P W All gene names: T27F6.7; 1N87; CE16516; WBGene00012106; WP:CE16516
T28A8.3 T28A8.3 P W All gene names: T28A8.3; 3O597; CE18974; Q9XU06_CAEEL; WBGene00012109; WP:CE18974
VW02B12L.4 VW02B12L.4 P W All gene names: adbp-1; VW02B12L.4; 2L735; 2L737; CE26728; Q23129_CAEEL; WBGene00012157; WP:CE26728
W01G7.4 W01G7.4 P W All gene names: W01G7.4; 2O353; CE21230; WBGene00012188; WP:CE21230
W02B12.7 W02B12.7 P W All gene names: klp-17; W02B12.7; 2L756; CE37934; WBGene00002227; WP:CE37934 WormBase description: klp-17 encodes a C-terminal kinesin motor protein orthologous to Drosophila NCD and Saccharomyces cerevisiae KAR3; by homology, KLP-17 is predicted to function as a minus-end directed motor; loss of klp-17 activity via RNAi results in embryonic lethality generally at the one- or two-cell stage with disorganized mitotic spindles and polyploid nuclei, suggesting that KLP-17 plays a role in chromosome segregation and germline development; in situ hybridization studies reveal that klp-17 mRNA is localized specifically to cell nuclei during early development, from the one-cell stage of embryogenesis until early larval stages; a klp-17::gfp transgene did not yield detectable GFP expression, but did result in a small percentage of morphologically abnormal males and intersexual animals that grew slowly and died upon reaching maturity, consistent with a role for klp-17 in chromosome dynamics. WormBase CDS description: kinesin, kinesin-14 family
W02D3.1 W02D3.1 P W All gene names: W02D3.1; 1H317; CE14418; WBGene00020931; WP:CE14418 WormBase description: cytochrome B5
W02D3.9 W02D3.9 P W All gene names: let-76; unc-37; W02D3.9; 1H320; CE14434; ESG; NM_059531; UNC37_CAEEL; WBGene00006773; WP:CE14434 WormBase description: The unc-37 gene encodes a transducin-like WD-repeat protein homologous to Drosophila GROUCHO that genetically interacts with components of the transcriptional Mediator complex. WormBase CDS description: transducin-like enhancer protein
W02F12.5 W02F12.5 P W All gene names: W02F12.5; 5H188; CE31083; WBGene00020950; WP:CE31083 WormBase description: dihydrolipoamide succinyltransferase
W03F8.3 W03F8.3 P W All gene names: W03F8.3; 4F953; CE17273; WBGene00020993; WP:CE17273 WormBase description: protein releasing factor
W06D4.4 W06D4.4 P W All gene names: W06D4.4; 1J638; CE16546; WBGene00012298; WP:CE16546
W06E11.4 W06E11.4 P W All gene names: W06E11.4; 3B254; CE30118; WBGene00021063; WP:CE30118 WormBase description: W06E11.4 encodes an ortholog of human SBDS (OMIM:607444, mutated in Shwachman-Bodian-Diamond syndrome) and S. cerevisiae SDO1; by homology, W06E11.4 is predicted to be a nucleolar protein that may be required for normal processing of rRNA; WS06E11.4 shares an operon with tag-266 and T19C3.7.
W08E3.3 W08E3.3 P W All gene names: tag-210; W08E3.3; 1N935; CE14708; TG210_CAEEL; WBGene00012344; WP:CE14708 WormBase description: GTP-binding protein like
W09B6.2 W09B6.2 P W All gene names: taf-6.1; W09B6.2; 2B421; CE27222; NM_061518; WBGene00006387; WP:CE27222
W10D5.3 W10D5.3 P W All gene names: gei-17; W10D5.3; 1J678; CE14782; CE24047; CE34390; CE34391; CE34392; CE38434; NM_060041; NM_060042; NM_060043; NR_000051; WBGene00001574; WP:CE14782; WP:CE24047; WP:CE34390; WP:CE34391; WP:CE34392; WP:CE38434 WormBase description: gei-17 encodes a protein containing a MIZ domain (Msx-interacting-zinc finger) that affects embryonic viability, vulval development, and body morphology; interacts with GEX-3 in yeast two-hybrid assays.
W10D9.5 W10D9.5 P W All gene names: W10D9.5; 2A760; CE14794; WBGene00021133; WP:CE14794
Y106G6H.14 Y106G6H.14 P W All gene names: Y106G6H.14; 1L48; CE24111; Q9U2Z5_CAEEL; WBGene00013724; WP:CE24111 WormBase description: Src homology domain 3 ; Ank repeat
Y106G6H.5 Y106G6H.5 P W All gene names: Y106G6H.5; 1L16; CE32511; WBGene00013718; WP:CE32511 WormBase description: The Y106G6H.5 gene encodes a homolog of the human gene SARDH, which when mutated leads to sarcosinemia, (OMIM:268900).
Y110A7A.6 Y110A7A.6 P W All gene names: Y110A7A.6; 1F701; CE29606; CE38000; WBGene00022456; WP:CE29606; WP:CE38000 WormBase description: phosphofructokinase
Y111B2A.13 Y111B2A.13 P W All gene names: Y111B2A.13; 3N715; CE26630; WBGene00013736; WP:CE26630 WormBase description: transcription initiation factor IIA gamma chain
Y111B2A.2 Y111B2A.2 P W All gene names: Y111B2A.2; 3N587; CE26622; WBGene00013728; WP:CE26622
Y113G7A.8 Y113G7A.8 P W All gene names: fre-1; tag-62; Y113G7A.8; 5U546; CE23279; NM_075474; WBGene00001485; WP:CE23279 WormBase description: fre-1 encodes an NADPH-dependent flavin reductase; fre-1 is the downstream gene in an operon with dcs-1, which encodes a scavenger mRNA decapping enzyme; reporter fusions using dcs-1 upstream sequence direct expression throughout the life cycle in neurons and pharyngeal muscle; expression is present in dauer larvae and enhanced by heat shock.
Y113G7B.23 Y113G7B.23 P W All gene names: psa-1; Y113G7B.23; 5U710; CE25208; NM_075505; Q9U2W6_CAEEL; WBGene00004203; WP:CE25208 WormBase description: psa-1 encodes an ortholog of SWI3, a component of the SWI/SNF complex that is conserved from yeast to mammals and that is involved in chromatin remodeling; psa-1 is probably required during mitosis of the T cells for asymmetric cell division, and in addition, is required for embryonic and larval development, as well as normal levels of fertility; psa-1 exhibits strong genetic interactions with lin-35/Rb, as psa-1 larval lethality and sterility at 20 degrees C are greatly enhanced in lin-35;psa-1 double mutants. WormBase CDS description: SWI/SNF protein
Y116A8A.9 Y116A8A.9 P W All gene names: map-2; Y116A8A.9; 4R792; CE24146; NM_070596; WBGene00003130; WP:CE24146
Y116A8C.30 Y116A8C.30 P W All gene names: Y116A8C.30; 4S44; CE27453; WBGene00013807; WP:CE27453
Y119D3B.15 Y119D3B.15 P W All gene names: Y119D3B.15; 3C284; CE34396; SEM1_CAEEL; WBGene00022492; WP:CE34396
Y17G7B.3 Y17G7B.3 P W All gene names: Y17G7B.3; 2M281; CE19036; WBGene00012459; WP:CE19036 WormBase description: Y17G7B.3 is orthologous to the human gene HYDROXYACYLGLUTATHIONE HYDROLASE (HAGH; OMIM:138760), which when mutated leads to disease. WormBase CDS description: Metallo-beta-lactamase superfamily
Y23H5B.6 Y23H5B.6 P W All gene names: Y23H5B.6; 1D65; CE25231; WBGene00021277; WP:CE25231
Y24D9A.3 Y24D9A.3 P W
Y25C1A.7 Y25C1A.7 P W All gene names: Y25C1A.7; 2D354; CE21475; CE38563; CE38564; WBGene00021294; WP:CE21475; WP:CE38563; WP:CE38564
Y32H12A.7 Y32H12A.7 P W All gene names: Y32H12A.7; 3G472; CE24201; WBGene00021315; WP:CE24201
Y34B4A.9 Y34B4A.9 P W All gene names: Y34B4A.9; CE27401; WBGene00021325; WP:CE27401; XF875
Y37E11AL.10 Y37E11AL.10 P W
Y37E11B.3 Y37E11B.3 P W All gene names: Y37E11B.3; 4E346; CE19613; WBGene00021376; WP:CE19613
Y37E3.10 Y37E3.10 P W All gene names: Y37E3.10; 1C643; CE29373; WBGene00021351; WP:CE29373
Y37E3.11 Y37E3.11 P W All gene names: Y37E3.11; 1C653; CE26830; Q9BKU2_CAEEL; WBGene00021352; WP:CE26830
Y37E3.17 Y37E3.17 P W All gene names: Y37E3.17; 1C713; CE30219; CE37062; WBGene00021355; WP:CE30219; WP:CE37062 WormBase description: Y37E3.17 is orthologous to the human gene UNKNOWN (PROTEIN FOR IMAGE:4608862) (DMGDH; OMIM:605849), which when mutated leads to disease.
Y37E3.4 Y37E3.4 P W All gene names: Y37E3.4; 1C633; CE26771; WBGene00021348; WP:CE26771
Y37E3.7 Y37E3.7 P W All gene names: rla-1; Y37E3.7; 1C636; CE26658; NM_170818; RLA1_CAEEL; WBGene00004409; WP:CE26658 WormBase description: rpa-1 encodes an acidic ribosomal subunit protein P1.
Y37H9A.1 Y37H9A.1 P W All gene names: Y37H9A.1; 1O369; CE20227; CE37562; WBGene00012576; WP:CE20227; WP:CE37562
Y38A10A.5 Y38A10A.5 P W All gene names: crt-1; Y38A10A.5; 5G580; CALR_CAEEL; CE21562; NM_072174; WBGene00000802; WP:CE21562 WormBase description: crt-1 encodes an ortholog of calreticulin (a calcium-binding molecular chaperone of the endoplasmic reticulum); crt-1 is dispensable for viability, but required for normal sperm development, male mating efficiency, some forms of necrotic cell death, and hermaphrodite fertility at high temperatures (which may reflect a stress response); crt-1 expression is induced by stress; CRT-1 protein binds Ca(2+) and can suppress heat-induced protein aggregation in vitro; crt-1(bz29) and crt-1(bz30) mutants suppress necrotic cell death induced either by mec-4(d) or by a constitutively activated Gas subunit; crt-1(bz29); crt-1's suppression of necrosis is itself partly reversed by thapsigargin, which enhances calcium release from the endoplasmic reticulum; crt-1(bz30), and crt-1(jh101) mutants grow more slowly, and have have reduced broods at 25 deg. C.; crt-1(jh101) mutants are slightly shorter than normal and have defective sperm; CRT-1 and ITR-1 serve partly redundant functions in vivo, since crt-1;itr-1(sa73) are highly infertile and slow-growing with greatly slowed defecation; a number of proteins, notably HSP-3/4 and PDI-2/3, are over-expressed in crt-1(jh101) mutants and crt-1(jh101);cnx-1(nr2009) double mutants. WormBase CDS description: calreticulin precursor
Y38A10A.6 Y38A10A.6 P W All gene names: Y38A10A.6; Y38A10A.G; 5G579; CE28975; WBGene00021391; WP:CE28975
Y38A8.1 Y38A8.1 P W All gene names: ndx-3; Y38A8.1; 2F243; CE07570; NM_062511; WBGene00003580; WP:CE07570 WormBase description: The ndx-3 gene encodes a homolog of peroxisomal CoA diphosphatases in both S. cerevisiae (PCD1) and C. elegans (NDX-8); more generally, NDX-3 protein belongs to the family of NUDIX hydrolases.
Y38C9A.2 Y38C9A.2 P W All gene names: cgp-1; Y38C9A.2; 5A598; CE21577; CGP1_CAEEL; NM_070736; WBGene00000480; WP:CE21577 WormBase description: GTP-binding protein
Y38F2AR.3 Y38F2AR.3 P W All gene names: Y38F2AR.3; 4D151; CE33865; WBGene00021421; WP:CE33865
Y39A1A.13 Y39A1A.13 P W All gene names: Y39A1A.13; 3L737; CE19132; WBGene00012651; WP:CE19132
Y39A1A.3 Y39A1A.3 P W All gene names: Y39A1A.3; 3L682; CE19121; WBGene00012643; WP:CE19121
Y39A1A.6 Y39A1A.6 P W All gene names: Y39A1A.6; 3L707; CE19125; WBGene00012645; WP:CE19125
Y39A3CL.1 Y39A3CL.1 P W All gene names: Y39A3CL.1; 3C935; CE32963; WBGene00021440; WP:CE32963
Y39A3CR.2 Y39A3CR.2 P W
Y39G10AL.3 Y39G10AL.3 P W All gene names: cdk-7; Y39G10AL.3; 1C850; CE30320; NM_058551; WBGene00000408; WP:CE30320 WormBase description: The cdk-7 gene encodes a cyclin-dependent kinase orthologous to human CDK7 (OMIM:601955) that is a component of the general transcription factor IIH (TFIIH) complex; CDK-7 is required during embryogenesis for mRNA transcription and phosphorylation of RNA polymerase II on serine 2 and serine 5, as well as for cell cycle progression, maintenance of ploidy, and completion of meiosis following fertilization.
Y39G10AR.9 Y39G10AR.9 P W All gene names: Y39G10AR.9; Y39G10AR.O; 1C875; CE28982; WBGene00021467; WP:CE28982
Y39G8B.1 Y39G8B.1 P W All gene names: Y39G8B.1; 2O262; CE21733; CE24243; WBGene00012722; WP:CE21733; WP:CE24243
Y40B1B.6 Y40B1B.6 P W All gene names: spr-5; Y40B1B.6; 1O41; CE20240; LSD1_CAEEL; NM_060965; WBGene00005010; WP:CE20240
Y40G12A.1 Y40G12A.1 P W All gene names: ubh-3; Y40G12A.1; 5G986; CE30001; NM_072252; WBGene00006723; WP:CE30001
Y41C4A.9 Y41C4A.9 P W All gene names: Y41C4A.9; 3M800; CE20249; WBGene00012756; WP:CE20249
Y41D4B.11 Y41D4B.11 P W All gene names: Y41D4B.11; 4C373; CE26095; WBGene00021514; WP:CE26095
Y43C5A.5 Y43C5A.5 P W All gene names: thk-1; Y43C5A.5; 4L44; CE19154; NM_069485; WBGene00006568; WP:CE19154 WormBase description: thymidine kinases
Y43F4B.5 Y43F4B.5 P W All gene names: Y43F4B.5; 3O391; CE16630; CE34117; O45934_CAEEL; WBGene00012803; WP:CE16630; WP:CE34117 WormBase description: Phosphoglucomutase and phosphomannomutase phosphoserine
Y43F4B.9 Y43F4B.9 P W All gene names: Y43F4B.9; 3O407; CE28123; WBGene00012806; WP:CE28123
Y43H11AL.1 Y43H11AL.1 P W All gene names: Y43H11AL.1; Y43H11AL.D; 2A514; CE32968; Q8IAA7_CAEEL; WBGene00021545; WP:CE32968
Y44F5A.1 Y44F5A.1 P W All gene names: Y44F5A.1; 3E324; 3F336; CE16634; O45938_CAEEL; WBGene00012858; WP:CE16634
Y45F3A.3 Y45F3A.3 P W All gene names: Y45F3A.3; 3L659; CE19166; CE39116; WBGene00012860; WP:CE19166; WP:CE39116 WormBase description: Acyl-CoA dehydrogenase
Y45G12B.1 Y45G12B.1 P W All gene names: nuo-5; Y45G12B.1; 5D185; CE21933; CE33340; CE33341; WBGene00021562; WP:CE21933; WP:CE33340; WP:CE33341 WormBase description: Y45G12B.1 is orthologous to human NADH-UBIQUINONE OXIDOREDUCTASE Fe-S PROTEIN 1 (NDUFS1; OMIM:157655), which when mutated leads to mitochondrial complex I deficiency.
Y46G5A.1 Y46G5A.1 P W All gene names: Y46G5A.1; 2N15; CE35367; CE35368; WBGene00012894; WP:CE35367; WP:CE35368; spds
Y47D3A.25 Y47D3A.25 P W All gene names: rab-35; Y47D3A.25; 3M396; CE24336; NM_067053; WBGene00004284; WP:CE24336 WormBase description: rab-35 encodes a small, monomeric Rab GTPase that is most closely related to the human and Drosophila Rab35 GTPases; by homology, RAB-35 is predicted to function as a membrane-associated GTPase required for intracellular vesicular trafficking and for regulation of endo- and exocytosis; however, as loss of rab-35 function via RNA-mediated interference (RNAi) does not result in any obvious abnormalities, the precise role of RAB-35 in C. elegans development and/or behavior is not yet known.
Y47D3A.4 Y47D3A.4 P W All gene names: cku-70; Y47D3A.4; 3M257; CE28984; NM_067037; WBGene00000519; WP:CE28984
Y48C3A.17 Y48C3A.17 P W All gene names: efl-2; Y48C3A.17; 2N699; CE24382; CE41054; CE41055; CE41056; NM_064424; Q9U289_CAEEL; WBGene00001162; WP:CE24382; WP:CE41054; WP:CE41055; WP:CE41056 WormBase description: The efl-2 gene encodes an E2F/DP1-like protein of as yet unknown function; comparative genomic analysis suggests that EFL-2 may be involved in apoptosis.
Y48C3A.7 Y48C3A.7 P W All gene names: mac-1; Y48C3A.7; 2N602; CE28132; NM_064413; WBGene00003119; WP:CE28132
Y48E1B.2 Y48E1B.2 P W All gene names: Y48E1B.2; 2N824; CE28989; CE28990; WBGene00013001; WP:CE28989; WP:CE28990 WormBase description: BR-1 protein-like
Y48E1C.3 Y48E1C.3 P W All gene names: Y48E1C.3; CE32976; WBGene00013016; WP:CE32976 WormBase description: Probable rabGAP domains
Y48G1C.3 Y48G1C.3 P W
Y48G8AL.5 Y48G8AL.5 P W All gene names: Y48G8AL.5; 1B671; CE30462; WBGene00021686; WP:CE30462
Y48G8AL.7 Y48G8AL.7 P W All gene names: Y48G8AL.7; 1B635; CE27275; WBGene00021687; WP:CE27275
Y49A3A.2 Y49A3A.2 P W All gene names: phi-51; vha-13; Y49A3A.2; Y49A3A.B; Y49A3A.C; CE22210; NM_074158; WBGene00013025; WP:CE22210 WormBase description: vha-13 encodes an ortholog of subunit A of the cytoplasmic (V1) domain of vacuolar proton-translocating ATPase (V-ATPase); VHA-13 is predicted to hydrolyse ATP as part of a cytosolic VHA-12/VHA-13 heterohexamer, whose activity drives the V-ATPase rotor; VHA-13 levels are lowered in mutants with either abnormally low or abnormally high calcineurin levels, and elevated in mutants lacking both calcineurin and calreticulin; VHA-13 is dispensable for alae formation, like the V1 subunit VHA-8, but not like the V0 subunits VHA-1 and VHA-4. WormBase CDS description: ATP synthase alpha and beta subunits ; ATP synthase ab C terminal
Y50D7A.8 Y50D7A.8 P W All gene names: Y50D7A.8; 3A954; CE39440; WBGene00021756; WP:CE39440
Y51H1A.5 Y51H1A.5 P W All gene names: hda-6; Y51H1A.5; 2O177; CE24411; NM_064509; WBGene00001838; WP:CE24411 WormBase description: Histone deacetylase family
Y51H4A.4 Y51H4A.4 P W All gene names: Y51H4A.4; 4R448; CE22330; Q9NAE4_CAEEL; WBGene00013100; WP:CE22330
Y51H7C.6 Y51H7C.6 P W All gene names: cogc-4; Y51H7C.6; 2B699; CE26151; CE26152; CE39055; WBGene00021784; WP:CE26151; WP:CE26152; WP:CE39055 WormBase description: cogc-4 encodes an ortholog of mammalian COG-4, a subunit of lobe A of the conserved oligomeric Golgi complex (COGC); COGC-4 is required for normal gonadal distal tip cell migration, a process that also requires seven other orthologs of COGC subunits; like other lobe A subunits in both C. elegans and S. cerevisiae, COGC-4 is strongly required for normal function, while lobe B subunits are only partially required in either worms or yeast.
Y52D3.1 Y52D3.1 P W All gene names: Y52D3.1; 3M39; CE19223; Q9XTC8_CAEEL; WBGene00013132; WP:CE19223 WormBase description: serine/threonine kinase
Y53C12A.1 Y53C12A.1 P W All gene names: wee-1.3; spe-37; Y53C12A.1; 2K4; CE14884; NM_063694; WBGene00006940; WP:CE14884 WormBase description: serine/threonine kinase
Y53C12A.4 Y53C12A.4 P W All gene names: mop-25.2; lss-18; Y53C12A.4; 2J992; CE14890; WBGene00013140; WP:CE14890 WormBase description: Mouse MO25 protein like
Y53C12B.2 Y53C12B.2 P W All gene names: Y53C12B.2; 2K30; CE14896; WBGene00013144; WP:CE14896
Y53G8AL.2 Y53G8AL.2 P W All gene names: Y53G8AL.2; 3E332; CE26163; WBGene00021800; WP:CE26163
Y54E10A.6 Y54E10A.6 P W All gene names: Y54E10A.6; 1D735; CE24450; WBGene00021828; WP:CE24450
Y54E10BR.3 Y54E10BR.3 P W All gene names: Y54E10BR.3; 1D595; CE22470; WBGene00021842; WP:CE22470
Y54E2A.2 Y54E2A.2 P W All gene names: Y54E2A.2; 2P34; CE20301; WBGene00013188; WP:CE20301
Y54E5A.4 Y54E5A.4 P W All gene names: npp-4; Y54E5A.4; 1P294; CE20315; NM_061151; Q9XWK3_CAEEL; WBGene00003790; WP:CE20315
Y54G11A.8 Y54G11A.8 P W All gene names: ddl-3; Y54G11A.8; 2O626; CE22480; CE35682; WBGene00013217; WP:CE22480; WP:CE35682
Y54G2A.23 Y54G2A.23 P W All gene names: Y54G2A.23; Y54G2A.O; Y94H6A_148.J; 4D692; CE30049; WBGene00021888; WP:CE30049 WormBase description: Y54G2A.23 is orthologous to the human gene ARGININE-RICH PROTEIN (ARMET; OMIM:601916), which has been found mutated in solid tumors of many different types, including pancreatic tumors.
Y54H5A.2 Y54H5A.2 P W All gene names: Y54H5A.2; 3G228; CE32024; WBGene00021900; WP:CE32024
Y54H5A.4 Y54H5A.4 P W All gene names: Y54H5A.4; 3G246; CE29883; WBGene00021902; WP:CE29883
Y56A3A.12 Y56A3A.12 P W All gene names: Y56A3A.12; 3M990; CE24467; CE24468; WBGene00013232; WP:CE24467; WP:CE24468
Y56A3A.18 Y56A3A.18 P W All gene names: Y56A3A.18; 3N8; CE22586; WBGene00013236; WP:CE22586
Y56A3A.2 Y56A3A.2 P W All gene names: Y56A3A.2; Y56A3A.C; 3M940; CE31840; WBGene00013225; WP:CE31840
Y56A3A.32 Y56A3A.32 P W All gene names: wah-1; Y56A3A.32; 3N87; CE31841; NM_067163; WBGene00006937; WP:CE31841
Y57A10A.27 Y57A10A.27 P W All gene names: Y57A10A.27; 2M560; CE25507; WBGene00013267; WP:CE25507
Y57A10A.3 Y57A10A.3 P W All gene names: Y57A10A.3; 2M441; CE25508; WBGene00013248; WP:CE25508
Y57G11C.10 Y57G11C.10 P W All gene names: gdi-1; Y57G11C.10; 4P556; CE14944; CE39445; NM_070387; WBGene00001558; WP:CE14944; WP:CE39445 WormBase description: gdi-1 encodes a member of the Rab GDP dissociation inhibitor (GDI) family with high similarity to Drosophila Gdi; expressed around the pharyngeal, vulval, and tail regions.
Y57G11C.11 Y57G11C.11 P W All gene names: coq-3; Y57G11C.11; 4P558; CE14946; CE40374; NM_070388; WBGene00000763; WP:CE14946; WP:CE40374 WormBase description: coq-3 encodes a putative 3,4-dihydroxy-5-hexaprenylbenzoate methyltransferase, orthologous to S. cerevisiae COQ3; by orthology, COQ-3 is predicted to be in a complex with COQ-4 (and perhaps COQ-6), and to be required for two different steps of ubiquinone synthesis; COQ-3 is required for viability, ubiquinone (coenzyme Q9) biosynthesis and for normally short lifespan; coq-3 null mutations are lethal; coq-3(RNAi) animals have reduced levels of coenzyme Q9 and superoxide, and have abnormally long lifespans.
Y59A8B.14 Y59A8B.14 P W All gene names: par-4; Y59A8B.14; 5S585; CE27410; NM_075132; WBGene00003919; WP:CE27410 WormBase description: par-4 encodes a serine-threonine kinase that is homologous to the human LKB1 kinase, mutations in which are associated with the cancer predisposition Peutz-Jeghers syndrome; par-4 activity is required for several distinct development processes, including establishment of embryonic asymmetry, lifespan extension, and dauer larval development, particularly inhibition of germline proliferation during dauer formation; PAR-4 is present in embryos, L4 larvae, males, and adult hermaphrodites; in the hermaphrodite gonad, PAR-4 is present at the actin-rich boundaries between syncytial nuclei, while in early embryos PAR-4 is present in the cytoplasm and at the cellular cortex. WormBase CDS description: serine-threonine protein kinase
Y59A8B.7 Y59A8B.7 P W All gene names: ebp-1; Y59A8B.7; 5S541; CE26217; NM_075125; Q9GRZ1_CAEEL; WBGene00013344; WP:CE26217
Y60A3A.13 Y60A3A.13 P W All gene names: frs-3; Y60A3A.13; 5U368; CE26224; NM_075451; WBGene00013361; WP:CE26224
Y62E10A.10 Y62E10A.10 P W All gene names: Y62E10A.10; 4O146; CE22698; WBGene00013378; WP:CE22698
Y62E10A.12 Y62E10A.12 P W All gene names: lsm-3; Y62E10A.12; 4O153; CE28143; NM_070178; WBGene00003077; WP:CE28143
Y62E10A.6 Y62E10A.6 P W All gene names: Y62E10A.6; 4O141; CE24542; WBGene00013376; WP:CE24542
Y66D12A.22 Y66D12A.22 P W All gene names: tin-10; Y66D12A.22; 3M592; CE28800; NM_067079; WBGene00006573; WP:CE28800; tim10
Y66H1B.4 Y66H1B.4 P W All gene names: spl-1; Y66H1B.4; 4B134; CE20348; NM_067512; WBGene00004981; WP:CE20348; spl
Y67D2.1 Y67D2.1 P W All gene names: Y67D2.1; 3C665; CE27306; CE34421; WBGene00022051; WP:CE27306; WP:CE34421
Y67H2A.1 Y67H2A.1 P W All gene names: Y67H2A.1; 4O40; CE32993; WBGene00013460; WP:CE32993
Y67H2A.5 Y67H2A.5 P W All gene names: Y67H2A.5; 4O65; CE28376; WBGene00013463; WP:CE28376
Y67H2A.6 Y67H2A.6 P W All gene names: csn-6; Y67H2A.6; 4O67; CE28377; NM_070156; WBGene00000818; WP:CE28377 WormBase description: csn-6 encodes a homolog of COP9 signalosome complex subunit 2 that affects embryonic viability and fertility.
Y67H2A.7 Y67H2A.7 P W All gene names: Y67H2A.7; 4O75; CE32274; WBGene00013464; WP:CE32274
Y69A2AR.2 Y69A2AR.2 P W All gene names: ric-8; Y69A2AR.2; 4D413; CE27516; CE33952; NM_067838; RIC8_CAEEL; WBGene00004367; WP:CE27516; WP:CE33952 WormBase description: ric-8 encodes a receptor-independent G alpha guanine nucleotide exchange factor (GEF); ric-8 activity is required for regulating heterotrimeric G protein signaling pathways that control asymmetric cell division in the embryo as well as synaptic transmission in the nervous system; in the 1-cell embryo, RIC-8 functions as a GEF for GOA-1 thereby regulating spindle morphology, position, and consequently, the first asymmetric cell division; in the nervous system, ric-8 interacts with the goa-1/egl-30 pathways to regulate neurotransmitter secretion and effect normal egg laying, movement, and body flexion; in vitro, RIC-8 preferentially binds GOA-1-GDP and increases the rate of GOA-1 GTP binding; in the early embryo, RIC-8 localizes to the cellular cortex, junctions between cells, asters of the mitotic spindle, the central spindle (kinetochore microtubules), the nuclear envelope, and chromatin; RIC-8's localization to the cortex and asters mirrors that of GOA-1, while localization to the cortex and central spindle is similar to that of the GOA-1 regulators GPR-1/2, whose subcellular localization is RIC-8-dependent; in later stage animals, RIC-8 is seen in head and tail ganglia, amphid processes, and the ventral nerve cord, as well as in larval nonneuronal cells, such as germline nuclei, where it localizes near the nuclear membrane.
Y6B3B.6 Y6B3B.6 P W
Y6D11A.1 Y6D11A.1 P W All gene names: Y6D11A.1; 3B479; CE30059; NM_064878; WBGene00000202; WP:CE30059
Y71F9AL.14 Y71F9AL.14 P W All gene names: Y71F9AL.14; 1D450; CE27022; WBGene00022118; WP:CE27022
Y71G12B.12 Y71G12B.12 P W All gene names: atgr-5; Y71G12B.12; 1C187; CE39065; CE39066; WBGene00022152; WP:CE39065; WP:CE39066
Y71G12B.8 Y71G12B.8 P W All gene names: Y71G12B.8; 1C263; CE27030; WBGene00022148; WP:CE27030
Y71H2AM.4 Y71H2AM.4 P W All gene names: Y71H2AM.4; 3D877; CE22940; WBGene00022169; WP:CE22940
Y71H2B.2 Y71H2B.2 P W All gene names: Y71H2B.2; 3D715; CE24629; WBGene00022192; WP:CE24629
Y71H2B.5 Y71H2B.5 P W All gene names: Y71H2B.5; 3D707; CE32548; WBGene00022195; WP:CE32548
Y73B6A.4 Y73B6A.4 P W All gene names: smg-7; Y73B6A.4; 4H506; CE25584; NM_068632; WBGene00004885; WP:CE25584
Y73B6BL.4 Y73B6BL.4 P W All gene names: Y73B6BL.4; 4H103; CE26298; WBGene00022233; WP:CE26298
Y73B6BL.5 Y73B6BL.5 P W All gene names: Y73B6BL.5; 4H97; CE29147; CE29148; CE31129; WBGene00022234; WP:CE29147; WP:CE29148; WP:CE31129
Y75B8A.17 Y75B8A.17 P W All gene names: gmn-1; Y75B8A.17; 3N314; CE23028; WBGene00013552; WP:CE23028
Y77E11A.6 Y77E11A.6 P W All gene names: Y77E11A.6; 4C174; CE25620; WBGene00022309; WP:CE25620
Y80D3A.1 Y80D3A.1 P W All gene names: wrs-1; Y80D3A.1; 5T334; CE35140; NM_075282; WBGene00006945; WP:CE35140 WormBase description: wrs-1 encodes a predicted tryptophanyl-tRNA synthetase that affects fertility, embryonic viability, growth, and locomotion WormBase CDS description: tryptophanyl-tRNA synthetase
Y82E9BR.14 Y82E9BR.14 P W All gene names: Y82E9BR.14; 3C500; CE27038; CE34433; WBGene00022347; WP:CE27038; WP:CE34433
Y87G2A.10 Y87G2A.10 P W All gene names: Y87G2A.10; 1O178; CE23139; WBGene00013598; WP:CE23139
Y87G2A.8 Y87G2A.8 P W All gene names: gpi-1; Y87G2A.8; 1O173; CE24687; CE36253; Q9U1Q2_CAEEL; WBGene00013597; WP:CE24687; WP:CE36253 WormBase description: Y87G2A.8 is orthologous to the human gene GLUCOSE PHOSPHATE ISOMERASE (GPI; OMIM:172400), which when mutated leads to disease.
Y87G2A.9 Y87G2A.9 P W All gene names: ubc-14; Y87G2A.9; 1O175; CE24688; NM_060980; WBGene00006709; WP:CE24688
Y8G1A.2 Y8G1A.2 P W All gene names: inx-13; opu-13; Y8G1A.2; 1E318; CE18356; NM_058811; WBGene00002135; WP:CE18356 WormBase description: inx-13 encodes an innexin, an integral transmembrane channel protein that is a structural component of invertebrate gap junctions; INX-13 is essential for larval development and osmoregulation, and may be a component of the gap junctions that link the excretory and hypodermal cells; INX-13 is expressed embryonically in hypodermis and post-embryonically, in hypodermal seam cells, the excretory cell, and the developing vulva and spermatheca; in hypodermal cells, INX-13 localizes to the plasma membrane at points of contact between adjacent cells. WormBase CDS description: membrane protein; probably a channel protein
Y92C3B.2 Y92C3B.2 P W All gene names: uaf-1; Y92C3B.2; 3C154; CE25626; CE27339; CE29149; CE30403; NM_064925; U2AF2_CAEEL; U2AF65; WBGene00006697; WP:CE25626; WP:CE27339; WP:CE29149; WP:CE30403 WormBase description: uaf-1 encodes the large subunit of U2AF, the U2 small nuclear ribonucleoparticle (snRNP) auxiliary factor and is a homolog of mammalian and fly U2AF65; UAF-1 has been shown to bind RNA and this binding is enhanced by UAF-2; the abundance of one alternative transcript appears to be increased during starvation and this transcript is retained in the nucleus; uaf-1 affects embryonic viability, based on RNAi analysis.
Y94H6A.8 Y94H6A.8 P W All gene names: Y94H6A.8; 4D482; CE39995; WBGene00022380; WP:CE39995
Y95D11A.1 Y95D11A.1 P W All gene names: Y95D11A.1; 1L537; CE23166; WBGene00013605; WP:CE23166
Y97E10AR.3 Y97E10AR.3 P W All gene names: Y97E10AR.3; 5I486; CE23172; WBGene00022398; WP:CE23172
Y97E10AR.5 Y97E10AR.5 P W All gene names: Y97E10AR.5; 5I492; CE26319; WBGene00022400; WP:CE26319
Y97E10AR.7 Y97E10AR.7 P W All gene names: Y97E10AR.7; 5I490; CE25642; MAPIP_CAEEL; WBGene00022402; WP:CE25642
ZC262.3 ZC262.3 P W All gene names: ZC262.3; 3J416; CE27345; CE29616; WBGene00022580; WP:CE27345; WP:CE29616 WormBase description: N-CAM IG domain
ZC395.6 ZC395.6 P W All gene names: gro-1; ZC395.6; 3G355; CE30119; NM_065721; WBGene00001740; WP:CE30119 WormBase description: tRNA isopentenyltransferase
ZC434.7 ZC434.7 P W All gene names: ZC434.7; 1K923; CE06582; CE41088; WBGene00013893; WP:CE06582; WP:CE41088
ZC506.3 ZC506.3 P W All gene names: pssy-1; ZC506.3; CE01681; WBGene00013920; WP:CE01681; XK585 WormBase description: phosphatidylserine synthase I
ZC513.5 ZC513.5 P W All gene names: ZC513.5; 5I519; ALG12_CAEEL; CE29152; WBGene00022629; WP:CE29152
ZK1010.2 ZK1010.2 P W All gene names: ZK1010.2; 3O64; CE33903; WBGene00014176; WP:CE33903
ZK1058.3 ZK1058.3 P W All gene names: ZK1058.3; 3F9; CE01103; WBGene00014203; WP:CE01103 WormBase description: ZK1058.3 is orthologous to the human gene UNNAMED PROTEIN PRODUCT (GALT; OMIM:606999), which when mutated leads to disease. WormBase CDS description: galactose-1-phosphate uridylyltransferase
ZK1127.12 ZK1127.12 P W All gene names: ZK1127.12; 2H341; CE33491; WBGene00022857; WP:CE33491
ZK1127.4 ZK1127.4 P W All gene names: ZK1127.4; 2H343; CE07643; WBGene00022851; WP:CE07643
ZK1128.6 ZK1128.6 P W All gene names: ZK1128.6; 3L221; CE29940; CE38015; WBGene00014232; WP:CE29940; WP:CE38015 WormBase description: tubulin tyrosine ligase
ZK1236.7 ZK1236.7 P W All gene names: ZK1236.7; 3J530; CE29628; WBGene00022865; WP:CE29628
ZK1248.11 ZK1248.11 P W All gene names: ZK1248.11; 2G118; CE02895; WBGene00022881; WP:CE02895
ZK1248.15 ZK1248.15 P W All gene names: ZK1248.15; 2G128; CE29633; WBGene00022883; WP:CE29633
ZK1320.7 ZK1320.7 P W All gene names: ZK1320.7; 2J963; BAT4_CAEEL; CE30717; WBGene00014256; WP:CE30717 WormBase description: single ankyrin motif
ZK177.4 ZK177.4 P W All gene names: ZK177.4; CE29069; NM_062652; NM_182117; WBGene00022672; WP:CE29069
ZK177.8 ZK177.8 P W All gene names: ZK177.8; 2F800; CE02097; CE07618; WBGene00022673; WP:CE02097; WP:CE07618
ZK353.7 ZK353.7 P W All gene names: ZK353.7; 3J492; CE00391; CUTC_CAEEL; WBGene00022702; WP:CE00391
ZK370.3 ZK370.3 P W All gene names: ZK370.3; 3J813; CE00540; CE29640; WBGene00022717; WP:CE00540; WP:CE29640 WormBase description: Talin
ZK370.7 ZK370.7 P W All gene names: ugtp-1; ZK370.7; 3J836; CE29642; WBGene00022721; WP:CE29642
ZK40.1 ZK40.1 P W All gene names: acl-9; ZK40.1; 5G935; CE28186; NM_072243; Q23087_CAEEL; WBGene00022646; WP:CE28186
ZK418.4 ZK418.4 P W All gene names: lin-37; ZK418.4; 3I160; CE25690; NM_066142; WBGene00003022; WP:CE25690
ZK484.3 ZK484.3 P W All gene names: ZK484.3; 1G646; CE15341; WBGene00022749; WP:CE15341
ZK550.4 ZK550.4 P W All gene names: TFIIE-alpha; ZK550.4; 4S201; CE16735; WBGene00013998; WP:CE16735
ZK637.10 ZK637.10 P W All gene names: trxr-2; ZK637.10; 3K5; CE15373; WBGene00014028; WP:CE15373 WormBase description: Glutathione reductase
ZK637.3 ZK637.3 P W All gene names: tag-256; ZK637.3; 3J981; CE00434; WBGene00014023; WP:CE00434
ZK652.2 ZK652.2 P W All gene names: tomm-7; ZK652.2; 3I951; CE00448; NM_066305; WBGene00022783; WP:CE00448
ZK652.9 ZK652.9 P W All gene names: coq-5; ZK652.9; 3I948; CE29014; NM_066303; WBGene00000765; WP:CE29014 WormBase description: coq-5 encodes a putative 2-hexaprenyl-6-methoxy-1,4-benzoquinone methyltransferase, homologous to COQ5 in S. cerevisiae and to a family of methyltransferases involved in ubiquinone, menaquinone, biotin and sterol biosynthesis and in phosphatidylethanolamine methylation; COQ-5 is required for ubiquinone (coenzyme Q9) biosynthesis and for normally short lifespan; coq-5 can transgenically rescue a coq-5 deletion in S. cerevisiae; coq-5(RNAi) animals have reduced levels of coenzyme Q9 and superoxide, and have abnormally long lifespans.
ZK678.1 ZK678.1 P W All gene names: lin-15A; ZK678.1; CE15383; LI15A_CAEEL; WBGene00023498; WP:CE15383; XQ353 WormBase description: lin-15A encodes a novel, hydrophilic protein; LIN-15A activity is required non-cell autonomously to negatively regulate vulval development; genetic analysis indicates that lin-15A, a class A synMuv gene, functions upstream of the LET-23 receptor tyrosine and redundantly with class B synMuv genes, such as lin-15B and lin-35 Rb and class C synMuv genes such as trr-1 and mys-1; although the lin-15A expression pattern is not yet known, genetic mosaic analysis suggests that, in regulating vulval induction, LIN-15A functions outside of the six vulval precursor cells P(3-8).p, likely acting instead in the surrounding hypodermal tissue. WormBase CDS description: LIN-15A protein
ZK686.3 ZK686.3 P W All gene names: ZK686.3; 3I858; CE00457; WBGene00022793; WP:CE00457 WormBase description: ZK686.3 is orthologous to the putative tumor suppressor N33 (OMIM:601385, associated with homozygous deletion in metastatic prostate cancer and with loss of function in other tumors); ZK686.3 is also homologous to the S. cerevisiae dolichyl-diphosphooligosaccharide-protein glycotransferase gamma chain (34-kD) subunit, OST3.
ZK688.8 ZK688.8 P W All gene names: gly-3; ZK688.8; 3J4; CE29649; NM_066321; WBGene00001628; WP:CE29649 WormBase description: gly-3 encodes an N-acetylgalactosaminyltransferase that is functional in vitro. WormBase CDS description: UDP-GalNAc
ZK792.1 ZK792.1 P W All gene names: ZK792.1; 4M435; CE24739; CE27418; WBGene00014076; WP:CE24739; WP:CE27418 WormBase description: Histidine acid phosphatases
ZK792.5 ZK792.5 P W All gene names: ZK792.5; 4M450; CE03826; WBGene00014078; WP:CE03826 WormBase description: Pumilio-family RNA binding domains (aka PUM-HD, Pumilio homology domain) (3 domains)
ZK856.8 ZK856.8 P W All gene names: ZK856.8; 5K682; CE06665; WBGene00014109; WP:CE06665 WormBase description: EF-hand calcium binding protein
ZK863.3 ZK863.3 P W All gene names: ZK863.3; 5M660; CE40344; WBGene00014123; WP:CE40344 WormBase description: Yeast LPG22P protein like
ZK863.7 ZK863.7 P W All gene names: rnp-1; ZK863.7; 5M673; CE15447; NM_073658; RNP1_CAEEL; WBGene00004384; WP:CE15447 WormBase description: RNP-1 protein