Welker et al 2007, let-7 targets, 12 genes

Gene list file name:Welker2007_table2
Type of gene identifier:Cosmid name
Description:let-7 targets from dcr-1 muntant microarray  
Organism:Caenorhabditis elegans (nematode)
Gene list type:Experimental

Gene name             Source Gene ID          Annotation                                                  Date       Added by    

C01G8.9 C01G8.9 P W All gene names: lss-4; C01G8.9; 1F870; CE30415; CE33359; WBGene00015314; WP:CE30415; WP:CE33359
C12C8.3 C12C8.3 P W All gene names: lep-1; lin-41; lin-41A; lin-41B; C12C8.3; 1J912; CE27062; CE27063; WBGene00003026; WP:CE27062; WP:CE27063 WormBase description: The lin-41 gene encodes a novel RBCC (Ring finger-B box-Coiled coil) protein that is a member of the NHL (NCL-1, HT2A, and LIN-41) family of proteins and is required for the proper temporal control of specific postembryonic cell fates; lin-41 translation is negatively regulated during L4 and adult stages by let-7, a small temporally regulated RNA (stRNA) that is complementary to two sites in the lin-41 3'UTR; LIN-41 is a widely expressed cytoplasmic protein and negatively regulates post-transcriptional expression of LIN-29, a transcription factor required for adult cell fates.
C18D1.1 C18D1.1 P W All gene names: die-1; C18D1.1; 2K352; CE01501; NM_063774; WBGene00000995; WP:CE01501 WormBase description: die-1 encodes a C2H2 zinc finger protein containing four fingers, homologous to CG18265-PA in Drosophila; DIE-1 is autonomously required in the posterior dorsal hypodermis for intercalation, for morphogenesis in other embryonic tissues, and for normal postembryonic growth and vulval development. WormBase CDS description: Zinc finger, C2H2 type (3 domains)
C48B6.6 C48B6.6 P W All gene names: mab-1; smg-1; C48B6.6; 1H478; CE30258; CE36919; NM_059569; WBGene00004879; WP:CE30258; WP:CE36919 WormBase description: kinase
F11A1.3 F11A1.3 P W All gene names: daf-12; mig-7; F11A1.3; CE27584; CE27585; CE27586; CE39240; WBGene00000908; WP:CE27584; WP:CE27585; WP:CE27586; WP:CE39240; XL285 WormBase description: daf-12 encodes a member of the steroid hormone receptor superfamily that affects dauer formation downstream of the TGF- and insulin signaling pathways, and affects gonad-dependent adult longevity together with DAF-16, chemosensory signal transduction, and distal tip cell migration and hypodermal and intestinal cell lineages during the L3 larval stage; expressed in the nucleus and in most cells; DAF-12 is homologous to human VITAMIN D RECEPTOR (VDR; OMIM:601769, mutated in vitamin D-resistant rickets.
F13D11.2 F13D11.2 P W All gene names: hbl-1; lin-57; F13D11.2; CE23646; CE27956; NM_076575; WBGene00001824; WP:CE23646; WP:CE27956; XG445 WormBase description: hbl-1 encodes a protein that contains nine putative zinc finger domains of the C2H2 type and affects embryonic viability, locomotion, egg laying, body morphology, and hypodermal differentiation; expressed in hypodermal precursor cells, neuronal precursor cells, and pharyngeal cells during embryogenesis and is primarily expressed in neurons during larval development.
F38A6.1 F38A6.1 P W All gene names: Ce-fkh-1; fkh-1; pha-4; F38A6.1; 5V229; CE15998; CE40228; CE40229; NM_075605; Q17381_CAEEL; WBGene00004013; WP:CE15998; WP:CE40228; WP:CE40229 WormBase description: Fork head domain, eukaryotic transcription factors
M117.2 M117.2 P W All gene names: ftt-1; par-5; M117.2; 14331_CAEEL; 4M586; CE06200; NM_069834; WBGene00003920; WP:CE06200 WormBase description: PAR-5 is a 14-3-3 protein. WormBase CDS description: 14-3-3 protein
T12F5.4 T12F5.4 P W All gene names: lin-59; T12F5.4; 1E282; CE13601; NM_058805; WBGene00003040; WP:CE13601
T25C12.1 T25C12.1 P W All gene names: lin-14; T25C12.1; CE03733; CE03734; NM_077515; NM_077516; WBGene00003003; WP:CE03733; WP:CE03734; XM103 WormBase description: lin-14 encodes a novel protein whose activity is required for specifying the division timings of a specific group of cells during postembryonic development; lin-14 loss-of-function mutations result in the premature appearance of later larval lineages, while gain-of-function mutations result in reiteration of L1 larval stages lineages; in addition, lin-14 acts as a positive regulator of AVM, PVM, and FLP touch cell development; in regulating developmental timing, lin-14 acts, in part, by positively regulating the activity of lin-28, which encodes a cytoplasmic protein also required for proper developmental timing; at hatching, LIN-14 is detected in the nuclei of blast cells and neurons; later, from the late L1 to adult stages, LIN-14 levels are negatively regulated by translational repression mediated by lin-4, a 22-nt small temporal RNA (stRNA) that is complementary to sequences in the lin-14 3' UTR. WormBase CDS description: embryonic nuclear protein lin-14 form A
Y53C12A.4 Y53C12A.4 P W All gene names: mop-25.2; lss-18; Y53C12A.4; 2J992; CE14890; WBGene00013140; WP:CE14890 WormBase description: Mouse MO25 protein like
ZK792.6 ZK792.6 P W All gene names: let-60; lin-34; ZK792.6; 4M454; CE03827; NM_069812; WBGene00002335; WP:CE03827 WormBase description: let-60 encodes a member of the GTP-binding RAS protooncogene family; let-60 activity is required for viability, vulval development, spicule development, germ line meiotic progression, posterior development of the hypodermis, chemotaxis, sex myoblast migration, and muscle membrane extension; let-60 acts genetically downstream of let-23 with respect to vulval development and upstream of the MAPK pathway with respect to chemotaxis; let-60 is expressed in neural, muscle, and hypodermal lineages. WormBase CDS description: LET-60 RAS protein