|Gene list file name:||Stetina2007_supp11|
|Type of gene identifier:||Cosmid name|
|Description:||Genes detected in both the Embryonic A-class enriched dataset and the AFD/AWB enriched dataset (Colosimo et al 2004)|
|Organism:||Caenorhabditis elegans (nematode)|
|Gene list type:||Experimental|
Gene name Source Gene ID Annotation Date Added by
B0507.1 B0507.1 P W All gene names: B0507.1; 5J259; CE28815; Q22886_CAEEL; WBGene00015218; WP:CE28815
C01B7.6 C01B7.6 P W All gene names: rpm-1; rpm-3; sad-3; sam-1; syd-3; C01B7.6; 5J282; CE06730; NM_072866; WBGene00004457; WP:CE06730
C02H7.3 C02H7.3 P W All gene names: aex-3; C02H7.3; CE16806; CE30850; NM_171618; WBGene00000086; WP:CE16806; WP:CE30850; XB370 WormBase description: The aex-3 gene encodes a guanine nucleotide exchange factor for the rab-3 GTPase that is orthologous to human MAP kinase activating protein containing death domain (MADD, OMIM:603584); AEX-3 is required for intracellular vesicle trafficking as well as synaptic vesicle release and interacts with CAB-1 and RAB-3 to regulate separate pathways for neural activities such as defecation and male mating, respectively; AEX-3 is also required for egg laying and locomotion; AEX-3 is expressed in nearly all neurons.
C05E11.3 C05E11.3 P W All gene names: C05E11.3; CE33029; WBGene00015494; WP:CE33029; XF199
C13F10.4 C13F10.4 P W All gene names: C13F10.4; 5H686; CE08145; WBGene00015743; WP:CE08145
C18A3.6 C18A3.6 P W All gene names: rab-3; rbl-3; C18A3.6; 2G12; CE20518; CE23555; RAB3/A; WBGene00004267; WP:CE20518; WP:CE23555; rab3 WormBase description: rab-3 encodes a rab3 homolog, a member of the Ras GTPase superfamily, and affects sensitivity to aldicarb and the distribution of synaptic vesicle populations and thereby affects synaptic transmission, track amplitude and speed of movement, chemotaxis to isoamyl alcohol, affects pharyngeal pump durations, and may only slightly affect male mating behavior; requires aex-3 for localization to synapse-rich regions in axons and it is expressed in most or all neurons. WormBase CDS description: synaptic vesicle-associated GTP-binding protein
C18F3.2 C18F3.2 P W All gene names: lad-1; sax-7; C18F3.2; 4I847; CE37202; CE38779; CE38935; CE38936; NM_068948; WBGene00004732; WP:CE37202; WP:CE38779; WP:CE38935; WP:CE38936 WormBase description: sax-7 encodes the C. elegans ortholog of L1CAM; SAX-7 is ubiquitously expressed at sites of cell-cell contact, and is required for germline development, embryonic morphogenesis, and gonadal morphogenesis; SAX-7 interacts physically with the ankyrin UNC-44, and nonphosphorylated SAX-7 is colocalized with UNC-44 at sites of cellular contact in vivo.
C18H9.7 C18H9.7 P W All gene names: rpy-1; C18H9.7; 2G994; CE01807; NM_062964; Q09485_CAEEL; WBGene00004507; WP:CE01807 WormBase description: rpy-1 is orthologous to the human gene 43KDA ACETYLCHOLINE RECEPTOR-ASSOCIATED PROTEIN (RAPSN; OMIM:601592), which when mutated leads to congenital myasthenic syndrome. WormBase CDS description: postsynaptic protein
C27H6.1 C27H6.1 P W All gene names: apt-10; C27H6.1; 5K448; CE08425; NM_073165; WBGene00000167; WP:CE08425 WormBase description: apt-10 encodes the C. elegans ortholog of the mammalian Stonins and Drosophila Stoned B, membrane-associated proteins that contain three distinct domains: a proline-rich domain, a stonin homology domain, and a domain paralogous to the mu-adaptin subunits of adaptor protein complexes 1-3; by homology, APT-10 is predicted to regulate the activity of the heteromeric AP-1 and AP-2 clathrin adaptor protein complexes, and thus to play a role in intracellular protein trafficking and endocytosis; in vivo, apt-10 is required for the secretion of EGL-17/FGF, required for sex myoblast migration, from the vulval precursor cell P6.p; loss of apt-10 activity via large-scale RNAi screens, however, does not result in any obvious abnormalities. WormBase CDS description: Adaptor complexes medium subunit family
C28D4.3 C28D4.3 P W All gene names: gln-6; C28D4.3; 4K504; CE08432; NM_069332; O02225_CAEEL; WBGene00001607; WP:CE08432 WormBase description: glutamine synthase
C31E10.8 C31E10.8 P W All gene names: C31E10.8; CE31423; WBGene00007849; WP:CE31423; XO622 WormBase description: S.pombe protein C4G8.04 like
C32E8.7 C32E8.7 P W All gene names: ric-19; C32E8.7; 1E346; CE39089; NM_058815; RIC19_CAEEL; WBGene00004368; WP:CE39089 WormBase description: The ric-19 gene encodes an evolutionarily conserved cytosolic protein involved in neuroendocrine secretion via association with secretory vesicles.
C34F6.9 C34F6.9 P W All gene names: C34F6.9; CE15678; O17646_CAEEL; WBGene00007943; WP:CE15678; XL838 WormBase description: Ubiquitin carboxyl-terminal hydrolases family 2
C35C5.1 C35C5.1 P W All gene names: sdc-2; C35C5.1; CE18542; NM_077523; WBGene00004746; WP:CE18542; XM151 WormBase description: The sdc-2 gene encodes a protein that represses transcription of X chromosomes to achieve dosage compensation, and that also represses the male sex-determination gene her-1 to elicit hermaphrodite differentiation.
C35C5.6 C35C5.6 P W All gene names: C35C5.6; CE03069; WBGene00007956; WP:CE03069; XM187
C38H2.1 C38H2.1 P W All gene names: C38H2.1; 3L461; CE32601; WBGene00008018; WP:CE32601 WormBase description: Probable rabGAP domains
C41G11.3 C41G11.3 P W All gene names: rgs-6; C41G11.3; CE30895; WBGene00004349; WP:CE30895; XG340 WormBase description: rgs-6 encodes a regulator of G protein signaling; by homology, RGS-6 is predicted to function as a GTPase-activating protein that binds G protein alpha subunits and negatively regulates heterotrimeric G protein signaling; loss of rgs-6 activity via RNAi or a deletion mutation results in no obvious defects, and likewise, rgs-6 overexpression has no measurable effect on egg-laying behavior, locomotion, or viability; the rgs-6 expression pattern has not yet been reported.
C52A11.4 C52A11.4 P W All gene names: mpz-1; C52A11.4; 2L48; CE40803; CE40834; CE40835; CE40836; CE40837; WBGene00003404; WP:CE40803; WP:CE40834; WP:CE40835; WP:CE40836; WP:CE40837 WormBase description: mpz-1 encodes a multi-PDZ domain containing protein; mpz-1 is expressed in nerve ring, pharyngeal, body, and tail neurons, as well as body wall and vulval muscles; MPZ-1 colocalizes with SNB-1 in neuronal puncta; the PDZ domain 10 of MPZ-1 binds the C-terminal PDZ-binding motif (ETFL) of the serotonin (5-HT) receptor SER-1, MPZ-1 binding enhances SER-1 activity, and mpz-1 is coexpressed with ser-1 in three neuron types and vulval muscle; MPZ-1 may also bind NPR-1 and ZC84.4; mpz-1(RNAi) animals have reduced 5-HT-stimulated egg-laying unless truncated SER-1 is transgenically expressed in vulval muscle; overexpressed MPZ-1 PDZ domain 10 also reduces SER-1-mediated egg-laying; mpz-1 may be translationally regulated by a small upstream open reading frame (uORF).
C52B9.1 C52B9.1 P W All gene names: cka-2; C52B9.1; CE27113; CE38493; NM_076333; WBGene00000510; WP:CE27113; WP:CE38493; XE909 WormBase description: cka-2 encodes an isoform of choline kinase whose activity has been verified in vitro; CKA-1 and CKA-2 comprise a related group ('A') of choline kinases; purified CKA-2 is dimeric, requires 1 mM Mg(2+) for optimal activity, and has a strong preference for choline over ethanolamine; CKA-2 has a pH optimum of 10 and a k(cat) of 74/s, close to the maximum rate observed for yeast and rat enzymes.
C53A5.9 C53A5.9 P W All gene names: C53A5.9; 5P36; CE08958; WBGene00008267; WP:CE08958 WormBase description: ring canal protein like
C53B7.1 C53B7.1 P W All gene names: rig-3; C53B7.1; CE06971; NM_076754; WBGene00004370; WP:CE06971; XH479
C54G10.3 C54G10.3 P W All gene names: pmp-3; C54G10.3; 5P133; CE05518; NM_074219; WBGene00004060; WP:CE05518 WormBase description: peroxisomal membrane protein (PMP70)
C56C10.13 C56C10.13 P W All gene names: dnj-8; C56C10.13; 2G886; CE28901; CE39709; NM_062939; WBGene00001026; WP:CE28901; WP:CE39709 WormBase description: This gene encodes a protein containing a DnaJ ('J') domain.
D1005.1 D1005.1 P W All gene names: D1005.1; CE06997; WBGene00016995; WP:CE06997; XC101 WormBase description: ATP citrate lyase
D2045.6 D2045.6 P W All gene names: cul-1; lin-19; D2045.6; 3L563; CE29089; WBGene00000836; WP:CE29089 WormBase description: cul-1 encodes a cullin, orthologous to Cdc53/Cul1 in S. cerevisiae and CUL-1 in humans (OMIM:603134), that is required both maternally and zygotically for developmentally programmed transitions from the G1 phase of the cell cycle to the GO phase or the apoptotic pathway, and that is probably also required for normally slow G1-to-S phase progression; CUL-1 physically interacts with eight Skp1-related proteins (SKR-1, -2, -3, -4, -7, -8, -9, and -10). WormBase CDS description: Cuticlin family
D2096.9 D2096.9 P W All gene names: D2096.9; 4J146; CE04307; WBGene00017076; WP:CE04307
F01G4.1 F01G4.1 P W All gene names: psa-4; F01G4.1; 4L895; CE05553; NM_069681; WBGene00004204; WP:CE05553 WormBase description: The psa-4 (phasmid socket absent) gene encodes an ortholog of SWI2/SNF2, a component of the SWI/SNF complex that is conserved from yeast to mammals and that is involved in chromatin remodeling; psa-4 is probably required during mitosis of the T cells for asymmetric cell division. WormBase CDS description: SNF2alpha like
F07B7.12 F07B7.12 P W All gene names: F07B7.12; 5J336; CE25842; WBGene00017190; WP:CE25842
F08B12.1 F08B12.1 P W All gene names: F08B12.1; CE03162; WBGene00008571; WP:CE03162; XM11 WormBase description: F08B12.1 is orthologous to the human gene AC133-2 ANTIGEN (PROML1; OMIM:604365), which when mutated leads to disease.
F10E7.9 F10E7.9 P W All gene names: F10E7.9; 2H398; CE04364; WBGene00017350; WP:CE04364 WormBase description: bumetanide-sensitive Na-K-Cl cotransporter
F10F2.4 F10F2.4 P W All gene names: F10F2.4; 3F717; CE31471; WBGene00008656; WP:CE31471 WormBase description: 2 leucine rich domains
F13B9.5 F13B9.5 P W All gene names: ksr-1; sar-2; sur-3; F13B9.5; CE25854; NM_076995; WBGene00002239; WP:CE25854; XI901
F17C8.1 F17C8.1 P W All gene names: acy-1; sgs-1; F17C8.1; 3F819; CE00955; NM_065569; WBGene00000068; WP:CE00955 WormBase description: The acy-1 gene encodes a protein with 40% identity to mammalian adenylyl cyclases, most closely related to the divergent mouse isoform type IX, that affects viability, muscle contraction, locomotion, and molting; it acts genetically downstream of gsa-1 and is expressed in excitable cells. WormBase CDS description: adenylate cyclase
F22B5.7 F22B5.7 P W All gene names: zyg-9; F22B5.7; F22B5.8; 2I753; CE20707; NM_063383; O61442_CAEEL; WBGene00006994; WP:CE20707 WormBase description: zyg-9 encodes a predicted microtubule-association protein (MAP) of the XMAP215 family; during early embryonic development, maternal zyg-9 activity is required for microtubule-dependent processes such as meiotic and mitotic spindle organization and pronuclear migration; further, zyg-9 is essential for formation of long astral microtubules; ZYG-9 is required for centrosomal localization of TAC-1, the sole C. elegans TACC family member, with which it interacts, and mutually stabilizes, in vivo; in early embryos, ZYG-9 localizes to the meiotic spindle and spindle poles, as well as to mitotic centrosomes; during metaphase and anaphase ZYG-9 localizes to the central spindle region, and during interphase ZYG-9 is cytoplasmic; proper localization of ZYG-9 to the meiotic spindle is dependent upon wild-type activity of MEI-1, an ATPase essential for meiotic spindle formation, while proper localization of ZYG-9 to centrosomes is dependent, at least in part, upon TAC-1. WormBase CDS description: elongation factor
F27D4.6 F27D4.6 P W All gene names: F27D4.6; 1I313; CE32394; WBGene00009190; WP:CE32394 WormBase description: zinc-finger protein
F29G6.2 F29G6.2 P W All gene names: F29G6.2; CE09792; Q93635_CAEEL; WBGene00009258; WP:CE09792; XM128
F31E8.2 F31E8.2 P W All gene names: ric-2; snt-1; unc-121; F31E8.2; 2H105; CE02711; CE28229; NM_062993; WBGene00004921; WP:CE02711; WP:CE28229; syt1 WormBase description: Synaptotagmin
F32B5.7 F32B5.7 P W All gene names: F32B5.7; 1D242; CE30526; WBGene00017980; WP:CE30526
F35C12.2 F35C12.2 P W All gene names: ncx-4; F35C12.2; 1K387; CE28020; CE40052; NM_060203; WBGene00003569; WP:CE28020; WP:CE40052 WormBase description: Na/Ca,K exchanger
F35C8.3 F35C8.3 P W All gene names: jkk-1; sek-2; F35C8.3; CE24941; NM_076512; Q9UAH1_CAEEL; WBGene00002177; WP:CE24941; XF989 WormBase description: jkk-1 encodes a member of the MAP kinase kinase superfamily that affects synaptic vesicle localization and is required in type-D motor neurons for normal locomotion; can function in the Hog1 MAP kinase pathway I in yeast as an activator of JNK and is expressed in most neurons
F37H8.1 F37H8.1 P W All gene names: lir-3; F37H8.1; 2L474; CE15994; NM_063994; WBGene00003046; WP:CE15994 WormBase description: lir-3 encodes a LIN-26-like zinc-finger protein that shares a unique C2H2 motif together with LIR-1, LIR-2 and LIN-26; as loss of lir-3 activity via mutation or RNAi results in no obvious abnormalities, the precise role of lir-3 in C. elegans development and/or behavior is not yet known. WormBase CDS description: Zinc finger, C2H2 type
F39B1.1 F39B1.1 P W All gene names: F39B1.1; CE05832; Q20187_CAEEL; WBGene00009552; WP:CE05832; XP854 WormBase description: phosphatidylinositol 3-kinase like
F39B2.8 F39B2.8 P W All gene names: F39B2.8; CE30529; WBGene00009558; WP:CE30529
F41D9.1 F41D9.1 P W All gene names: F41D9.1; CE30984; WBGene00018281; WP:CE30984; XJ1
F45H7.6 F45H7.6 P W All gene names: F45H7.6; 3E468; CE01588; WBGene00009738; WP:CE01588 WormBase description: Yeast ORF YKL162
F47A4.2 F47A4.2 P W All gene names: dpy-22; mdt-12; psa-6; sop-1; F47A4.2; CE16058; NM_077244; WBGene00001081; WP:CE16058; XK430 WormBase description: dpy-22 encodes a broadly expressed protein, homologous to the human transcriptional mediator protein TRAP230, which is involved in WNT and RAS signaling, as well as in dosage compensation; DPY-22 has a C-terminal glutamine-rich domain that is dispensable for inhibition of RAS-dependent cell differentiation, but is required for inhibition of BAR-1-dependent gene expression.
F48E3.2 F48E3.2 P W All gene names: F48E3.2; CE02750; WBGene00018603; WP:CE02750; XI108 WormBase description: Glucose transporter
F48E3.3 F48E3.3 P W All gene names: F48E3.3; CE02751; WBGene00018604; WP:CE02751; XI114 WormBase description: killer toxin-resistance protein (S. cerevisiae)
F48F7.4 F48F7.4 P W All gene names: pqn-39; F48F7.4; CE05891; NM_077924; WBGene00004126; WP:CE05891; XO584 WormBase description: The protein product of this gene is predicted to contain a glutamine/asparagine (Q/N)-rich ('prion') domain, by the algorithm of Michelitsch and Weissman (as of the WS77 release of WormBase, i.e., in wormpep77).
F49E10.1 F49E10.1 P W All gene names: F49E10.1; CE29965; WBGene00018639; WP:CE29965; XG519
F56A11.5 F56A11.5 P W All gene names: F56A11.5; 4B322; CE17120; O44517_CAEEL; WBGene00018925; WP:CE17120
F56B6.5 F56B6.5 P W All gene names: uvt-6; F56B6.5; CE31186; CE39375; NM_076205; WBGene00006864; WP:CE31186; WP:CE39375; XE149 WormBase description: uvt-6 encodes a G protein-coupled receptor that is most similar to the mammalian somatostatin receptors; uvt-6 was first identified in molecular analyses of gene products linked to the vitellogenin (vit) loci on the X chromosome; as loss of uvt-6 activity via large-scale RNAi screens does not result in any obvious abnormalities, the precise role of uvt-6 in C. elegans development and/or behavior is not yet known; uvt-6 mRNA is expressed weakly in adult hermaphrodites.
F56D12.4 F56D12.4 P W All gene names: jip-1; F56D12.4; 2B639; CE37024; CE39160; CE39161; NM_061549; WBGene00002176; WP:CE37024; WP:CE39160; WP:CE39161 WormBase description: JIP-1 is partly similar to the human gene ISLET-BRAIN 1 (MAPK8IP1; OMIM:604641), which when mutated leads to type II diabetes.
F56F10.2 F56F10.2 P W All gene names: F56F10.2; CE31187; WBGene00018985; WP:CE31187; XB481
F56H9.5 F56H9.5 P W All gene names: lin-25; F56H9.5; 5N137; CE05975; NM_073761; WBGene00003011; WP:CE05975 WormBase description: lin-25
F57F5.5 F57F5.5 P W All gene names: kin-13; pkc-1; ttx-4; F57F5.5; 5M496; CE29092; NM_073613; WBGene00004032; WP:CE29092 WormBase description: pkc-1 encodes a serine/threonine protein kinase that is orthologous to mammalian protein kinase C epsilon (PRKCE), a member of the nPKC subgroup of the protein kinase C superfamily; together with UNC-13, PKC-1 may act downstream of goa-1 to modulate phorbol ester-induced stimulation of acetylcholine release at NMJs; PKC-1 positively regulates locomotion, and affects thermotaxis and chemotaxis together with kin-11; PKC-1 is required for regulating several behaviors including sensation of volatile and soluble compounds, osmolarity, and temperature (thermosensation); PKC-1 is also required for phorbolester-induced stimulation of acetylcholine release at neuromuscular junctions; PKC-1 localizes to the processes and cell bodies of approximately 75 sensory neurons and interneurons, and pkc-1 mRNA is detectable at varying levels during larval and adult stages. WormBase CDS description: Phorbol esters / diacylglycerol binding domain (2 domains), Protein kinase C terminal domain
F58E10.1 F58E10.1 P W All gene names: F58E10.1; 5O468; CE30677; CE40076; WBGene00010259; WP:CE30677; WP:CE40076
F59D12.1 F59D12.1 P W All gene names: F59D12.1; CE11490; WBGene00010329; WP:CE11490; XQ289 WormBase description: G-protein coupled receptor (gastrin/cholecystokinin)
H05G16.1 H05G16.1 P W All gene names: frm-3; H05G16.1; CE11568; NM_077533; WBGene00001490; WP:CE11568; XM199 WormBase description: frm-3 encodes a protein containing a FERM domain (Band 4.1 family); expressed in a few cells in the head. WormBase CDS description: Band 4.1 family
H20J04.2 H20J04.2 P W All gene names: H20J04.2; 2E639; CE27187; WBGene00019217; WP:CE27187
K01A2.10 K01A2.10 P W All gene names: K01A2.10; 2A612; CE19519; Q9TZ50_CAEEL; WBGene00019284; WP:CE19519
K02E10.8 K02E10.8 P W All gene names: syg-1; K02E10.8; CE37121; NM_076056; WBGene00006365; WP:CE37121; XD128 WormBase description: syg-1 encodes a novel transmembrane protein that is a member of the immunoglobulin superfamily of proteins; during larval development, SYG-1 activity is required cell autonomously within the HSNL neuron to specify proper synaptic specificity with its targets, such as vulval muscles and the VC neuron; in regulating synapse formation, SYG-1 acts as a receptor for a second immunoglobulin superfamily protein, SYG-2, a synaptic guidepost protein that interacts with SYG-1 and whose activity is essential for proper SYG-1 localization in HSNL; expression of a SYG-1::GFP reporter fusion in HSNL under the control of the unc-86 promoter reveals that SYG-1 localizes to axons and accumulates at future sites of synaptic vesicle clustering, while expression under an endogenous reporter reveals weak expression in head motorneurons, occasionally in HSN neurons, and in other cells in the vulval region.
K04D7.4 K04D7.4 P W All gene names: K04D7.4; 4K950; CE40655; WBGene00010558; WP:CE40655 WormBase description: protein-tyrosine phosphatase
K05B2.5 K05B2.5 P W All gene names: pes-22; K05B2.5; CE34052; CE39589; CE39590; NM_076437; WBGene00003986; WP:CE34052; WP:CE39589; WP:CE39590; XF540 WormBase description: pes-22 encodes a predicted transmembrane protein that is a member of the monocarboxylate porter subfamily of the major facilitator superfamily of transmembrane transporters; pes-22 was identified in promoter-trapping screens and by homology, is predicted to function in the transport of lactate and pyruvate across cell membranes, possibly as part of a metabolic pathway that allows these metabolites to be converted back to glucose when the organism is under high energy demand; however, as loss of pes-22 activity via RNA-mediated interference (RNAi) does not result in any obvious abnormalities, the precise role of PES-22 in C. elegans development and/or behavior is not yet known; a pes-22 reporter is expressed in the excretory gland cells and the ventral nerve cord from late embryogenesis through adulthood, and also in the intestine in late embryos and early larvae.
K09E4.4 K09E4.4 P W All gene names: K09E4.4; 2O406; CE32692; WBGene00010722; WP:CE32692 WormBase description: K09E4.4 is orthologous to the human gene N-ACETYLGALACTOSAMINIDASE, ALPHA- (NAGLU; OMIM:104170), which when mutated leads to disease.
K09E9.3 K09E9.3 P W All gene names: K09E9.3; CE12014; WBGene00010726; WP:CE12014; XQ232
K10B3.10 K10B3.10 P W All gene names: imo-1; spc-1; K10B3.10; CE07373; NM_076136; WBGene00004951; WP:CE07373; XD738 WormBase description: spectrin alpha chain
K10D3.2 K10D3.2 P W All gene names: unc-14; K10D3.2; 1H700; CE25055; NM_059617; WBGene00006753; WP:CE25055 WormBase description: The unc-14 gene encodes an activity required for both axonogenesis and sex myoblast migration.
M01F1.7 M01F1.7 P W All gene names: M01F1.7; 3E612; CE33673; WBGene00010813; WP:CE33673 WormBase description: M01F1.7 encodes a phosphatidylinositol transfer protein, with a C-terminal DDHD domain, that is orthologous to RETINAL DEGENERATION B (RDGB) in D. melanogaster, as well as other orthologs in mammals (NIR1-3); M01F1.7 is expressed in the egg membrane, the germline, the spermatheca and three pairs of head neurons; while M01F1.7 would be expected to mediate PIP(2) signalling in either neuronal function or cytokinesis, it has not yet had a published mutant phenotype, and has no obvious function in mass RNAi assays. WormBase CDS description: RETINAL DEGENERATION B PROTEIN (PROBABLE CALCIUM TRANSPORTER RDGB)
R01E6.7 R01E6.7 P W All gene names: R01E6.7; CE38968; WBGene00010971; WP:CE38968; XO182
R02D5.4 R02D5.4 P W All gene names: R02D5.4; 5O964; CE12492; WBGene00010978; WP:CE12492
T02C5.5 T02C5.5 P W All gene names: unc-2; T02C5.5; CE29459; CE31225; CE34591; CE34980; NM_171638; NM_171639; NM_171942; WBGene00006742; WP:CE29459; WP:CE31225; WP:CE34591; WP:CE34980; XD330 WormBase description: unc-2 encodes a calcium channel alpha subunit required for desensitization to dopamine, normal flexion and speed during movement, normally low sensitivity of whole animals to serotonin, and neuronal migrations promoted by humoral serotonin; UNC-2 is orthologous to human CACNA1A (OMIM:601011, mutated in familiar hemiplegic migraine or episodic ataxia 2) and to Drosophila CACOPHONY; UNC-2 is expressed primarily in motor neurons, several sensory neurons, and HSN and VC neurons controlling egg-laying.
T19B4.7 T19B4.7 P W All gene names: unc-40; unc-91; T19B4.7; 1G248; CE25115; NM_059263; WBGene00006776; WP:CE25115 WormBase description: The unc-40 gene encodes a netrin receptor that is required to guide dorsal-ventral cell and axon migrations, and is required for correct polarization and migration of the neuroblasts QL and QR. WormBase CDS description: membrane protein
T19D12.6 T19D12.6 P W All gene names: T19D12.6; 2G928; CE40124; WBGene00020581; WP:CE40124 WormBase description: laminin repeats; EGF-like repeats
T20B5.1 T20B5.1 P W All gene names: apa-2; apt-4; T20B5.1; CE28680; NM_077171; WBGene00000161; WP:CE28680; XJ961 WormBase description: The apt-4 gene encodes an adaptin: specifically, it encodes an ortholog of the alpha subunit of adaptor protein complex 2 (AP-2). WormBase CDS description: alpha-adaptin
VT23B5.2 VT23B5.2 P W All gene names: VT23B5.2; CE20122; WBGene00012154; WP:CE20122 WormBase description: The VT23B5.2 gene encodes a homolog of human CHS, when when mutated leads to Chediak-Higashi syndrome (OMIM:214500). WormBase CDS description: FYVE zinc finger
W03F8.2 W03F8.2 P W All gene names: W03F8.2; 4F957; CE35040; WBGene00020992; WP:CE35040 WormBase description: protein kinase
W03G11.4 W03G11.4 P W All gene names: W03G11.4; CE18331; WBGene00012226; WP:CE18331; XM696
W04C9.5 W04C9.5 P W All gene names: W04C9.5; 1A936; CE40271; WBGene00021027; WP:CE40271
W09C3.3 W09C3.3 P W All gene names: W09C3.3; 1F275; CE36728; WBGene00021111; WP:CE36728
Y105C5A.15 Y105C5A.15 P W All gene names: Y105C5A.15; 4Q485; CE35192; WBGene00013639; WP:CE35192
Y22D7AR.13 Y22D7AR.13 P W All gene names: 5HT-Ce; cer-1; ser-4; Y22D7AR.13; 3C814; CE29370; NM_065051; WBGene00004779; WP:CE29370 WormBase description: ser-4 encodes an ortholog of mammalian 5-HT1 metabotropic serotonin receptors; SER-4 is required for normal inhibition of movement by 5-HT, with ser-4 mutants being hyperactive; SER-4 is partly required for male tail curling, with ser-4 mutants showing reduced curling in exogenous 5-HT; SER-4 is dispensable for the stimulation of egg-laying by 5-HT and by the uptake inhibitor fluoxetine; SER-4 may actually inhibit egg-laying, since egg-laying ser-4 mutants are moderately hypersensitive to 5-HT, and mutant ser-4 hermaphrodites are partly depleted of eggs, suggesting that their egg-laying is weakly constitutive; however, SER-4 is required for stimulation of egg-laying by the tricyclic antidepressant imipramine, suggesting that imipramine drives HSNs to secrete some non-5-HT neurotransmitter which then activates SER-4; SER-4 is expressed in neurons (RIB and RIS, other head, pharyngeal, sublateral, retrovesicular ganglion, PVT, and either DVA or DVC); SER-4 has a low affinity for serotonin (5-HT), and overall pharmacological similarities to mammalian 5-HT1 receptors; SER-4 is probably antagonized by mianserin; heterologously expressed SER-4, when challenged with 5-HT, diminishes intracellular adenylate cyclase activity; LIM-6 is required for normal expression of SER-4 in RIS interneurons.
Y22F5A.3 Y22F5A.3 P W All gene names: ric-4; snap-25; Y22F5A.3; 5K742; CE32008; NM_073240; WBGene00004364; WBGene00012495; WP:CE32008 WormBase description: Y22F5A.3 encodes an ortholog of vertebrate SNAP-25 and S. cerevisiae Sec9p; SNAP-25 is associated with synaptosomes, required for axonal growth in vivo, and targeted by botulinum neurotoxins; UNC-86 and MEC-3 are required for Y22F5A.3 expression, and act on a regulatory element (I2h) in Y22F5A.3 conserved between the first introns of C. elegans and C. briggsae Y22F5A.3 genes; other conserved motifs in the promoter region (P1 and P2) and first intron (I1h, I1m, I2h, and I2m) are required for Y22F5A.3 expression in DA and DD motor neurons (P1), DB and DA neurons (I1m and I2m), amphid and phasmid neurons (P2), pharyngeal neurons (I1h), and mechanosensory neurons (I2h); Y22F5A.3 has no obvious function in mass RNAi assays WormBase CDS description: SNAP-25 family
Y32H12A.8 Y32H12A.8 P W All gene names: Y32H12A.8; 3G476; CE28516; WBGene00021316; WP:CE28516
Y53F4B.12 Y53F4B.12 P W All gene names: Y53F4B.12; Y53F4B.O; 2P311; CE22401; WBGene00013159; WP:CE22401
Y53G8AL.1 Y53G8AL.1 P W All gene names: Y53G8AL.1; Y53G8AL.C; 3E327; CE40218; WBGene00021799; WP:CE40218
Y57G11C.37 Y57G11C.37 P W All gene names: Y57G11C.37; 4P439; CE40485; WBGene00013326; WP:CE40485
Y60A3A.7 Y60A3A.7 P W All gene names: Y60A3A.7; 5U427; CE24531; WBGene00013358; WP:CE24531
Y73B3A.9 Y73B3A.9 P W All gene names: Y73B3A.9; CE27335; WBGene00022211; WP:CE27335; XA788
Y7A5A.5 Y7A5A.5 P W All gene names: Y7A5A.5; Y7A5A.E; CE21330; WBGene00012411; WP:CE21330; XQ404
ZC196.6 ZC196.6 P W All gene names: ZC196.6; 5J207; CE36057; WBGene00022550; WP:CE36057
ZC21.2 ZC21.2 P W All gene names: trp-1; ZC21.2; 3J631; CE33009; CE39997; NM_066480; TRPL_CAEEL; WBGene00006614; WP:CE33009; WP:CE39997; strpc1 WormBase description: trp-1 encodes a predicted transmembrane protein with similarity to transient receptor potential (TRP) ion channels; a TRP-1::GFP reporter fusion is expressed in motor neurons, interneurons, vulval and intestinal muscles, and the BAG sensory neuron; as loss of trp-1 activity via deletion mutation or large-scale RNAi results in no obvious defects, the precise role of trp-1 in C. elegans development and/or behavior is not yet known.
ZC84.3 ZC84.3 P W All gene names: ZC84.3; 3K276; CE15022; WBGene00013847; WP:CE15022
ZK287.1 ZK287.1 P W All gene names: ZK287.1; 5K149; CE06610; WBGene00013962; WP:CE06610
ZK688.9 ZK688.9 P W All gene names: ZK688.9; 3I972; CE40006; WBGene00022803; WP:CE40006
ZK792.7 ZK792.7 P W All gene names: ZK792.7; 4M461; CE40542; WBGene00014079; WP:CE40542 WormBase description: Yeast CC1 like