Liu et al 2005, Strongly regulated genes, 1236 genes Gene list file name: Liu2005_supps2 Type of gene identifier: MA primer pair (sjj) Description: Strongly regulated genes ith a regulation greater than 2.145 fold Organism: Caenorhabditis elegans (nematode) Gene list type: Experimental Gene name Source Gene ID All gene names WormBase description WormBase CDS description Proteome description Member of lists () Other annotations AH10.1 AH10.1 AH10.1; 5O629; CE07655; WBGene00007082; WP:CE07655 4-coumarate:coenzyme A ligase B0019.1 B0019.1 amx-2; B0019.1; 1N352; CE40797; NM_060835; WBGene00000138; WP:CE40797 B0024.1 B0024.1 col-149; B0024.1; 5K772; CE05146; NM_073245; Q17417_CAEEL; WBGene00000722; WP:CE05146 collagen B0024.2 B0024.2 col-150; B0024.2; 5K774; CE05147; NM_073246; WBGene00000723; WP:CE05147 collagen B0213.10 B0213.10 cyp-34A5; B0213.10; 5E430; CE16781; NM_071698; WBGene00015040; WP:CE16781 cytochrome P450 B0213.11 B0213.11 cyp-34A6; B0213.11; 5E432; CE35205; NM_071699; WBGene00015041; WP:CE35205 cytochrome P-450 B0213.14 B0213.14 cyp-34A8; B0213.14; 5E444; CE16784; NM_071701; WBGene00015043; WP:CE16784 cytochrome P450 B0213.15 B0213.15 ccp-34A9; cyp-34A9; dod-16; B0213.15; 5E446; CE30582; CE39545; CE39546; NM_071702; WBGene00015044; WP:CE30582; WP:CE39545; WP:CE39546 cytochrome P450 B0222.6 B0222.6 col-144; B0222.6; 5J640; CE30585; NM_072973; WBGene00000717; WP:CE30585 B0222.7 B0222.7 col-145; B0222.7; 5J642; CE06698; NM_072974; WBGene00000718; WP:CE06698 B0222.8 B0222.8 col-10; B0222.8; 5J644; CE06699; NM_072975; WBGene00000599; WP:CE06699 col-10 encodes a collagen protein; expressed exclusively in hypodermal cells B0228.7 B0228.7 B0228.7; 2I48; CE34630; WBGene00015064; WP:CE34630 B0238.13 B0238.2 B0238.13; 5F722; CE29530; WBGene00015077; WP:CE29530 carboxylesterase B0244.2 B0244.2 ida-1; B0244.2; 3G855; CE31867; NM_065844; WBGene00002048; WP:CE31867; ia2 ida-1 encodes a protein tyrosine phosphatase-like receptor, orthologous to the mammalian type I diabetes autoantigens IA-2 and phogrin that are expressed in dense core vesicles of neuroendocrine tissue and involved in regulated protein secretion; in C. elegans, IDA-1 appears to be required for regulating presynaptic neurotransmission and in particular, for the neuropeptidergic control of egg-laying; ida-1 interacts genetically with unc-31 and unc-64, which encode proteins required for dense core vesicle fusion and exocytosis; ida-1 expression is detected in a subset of neurons in the anterior nerve ring, the ventral nerve cord, the tail, and the vulva, including the VC vulval motoneurons and the HSN egg-laying neurons; ida-1 is also detected in the vulval uv1 cells, non-neuronal cells that contain neurosecretory-like vesicles. protein tyrosine phosphatase B0250.1 B0250.1 rpl-2; B0250.1; 5U949; CE18478; NM_075539; RL8_CAEEL; WBGene00004413; WP:CE18478 rpl-2 encodes a large ribosomal subunit L8 protein. Ribosomal Proteins L2 B0250.7 B0250.7 B0250.7; 5U942; WBGene00007124 B0280.9 B0280.9 B0280.9; 3I212; CE00816; WBGene00015104; WP:CE00816 B0284.1 B0284.1 B0284.1; 3F467; CE40594; WBGene00007131; WP:CE40594 B0284.2 B0284.2 B0284.2; 3F473; CE00651; WBGene00007132; WP:CE00651 B0286.5 B0286.5 fkh-6; B0286.5; 2E670; CE03865; NM_062374; WBGene00001438; WP:CE03865 fkh-6 encodes one of 15 C. elegans forkhead transcription factors; fkh-6 is required for several aspects of male gonadogenesis including asymmetric cell division, cell migration and sex determination and appears to act downstream of tra-1; FKH-6 is specifically expressed in the gonad. fork head DNA-binding protein B0294.1 B0294.1 B0294.1; CE19656; WBGene00015117; WP:CE19656; XC512 B0331.2 B0331.2 B0331.2; 5K140; CE15552; WBGene00007141; WP:CE15552 phosphate permease like B0336.10 B0336.10 rpl-23; B0336.10; 3G794; CE00778; NM_065830; WBGene00004435; WP:CE00778 rpl-23 encodes a large ribosomal subunit L23 protein. B0361.6 B0361.6 B0361.6; 3I366; CE00835; WBGene00015160; WP:CE00835 B0365.7 B0365.7 B0365.7; 5N631; CE40345; WBGene00007154; WP:CE40345 dynein B0393.1 B0393.1 rps-0; B0393.1; 3F842; CE00854; NM_065577; RSSA_CAEEL; WBGene00004469; WP:CE00854 rps-0 encodes a small ribosomal subunit SA protein that appears to function as both a ribosomal component and a laminin receptor; by homology, RPS-0 is predicted to play roles in protein biosynthesis and cell adhesion; in C. elegans, RPS-0 activity is required for embryonic and germline development, vulval morphogenesis, and the overall health of the animal. 40S ribosomal protein B0399.2 B0399.2, Y116F11A.QQ B0399.2; 5U26; CE36626; WBGene00007177; WP:CE36626 Y39B6A.5 B0413.1 Y39B6A.5; 5T632; CE21672; WBGene00012668; WP:CE21672 B0414.3 B0414.3 hil-5; B0414.3; 1G351; CE07733; NM_059277; WBGene00001856; WP:CE07733 histone H1 B0432.3 B0432.3 B0432.3; 2A579; CE07741; WBGene00015185; WP:CE07741 B0462.1 B0462.1 B0462.1; 5S807; CE15554; WBGene00007181; WP:CE15554 B0491.2 B0491.2 rol-5; sqt-1; B0491.2; 2L626; CE02104; NM_064020; Rol; WBGene00005016; WP:CE02104 sqt-1 encodes a cuticle collagen; during larval and adult development, sqt-1 activity is required, likely redundantly, for normal cuticle, and hence organismal, morphology; sqt-1 mRNA abundance oscillates during larval development, peaking at one point during each larval stage and peaking again in adults; sqt-1 transcripts are also detected in animals at the L1-L2d molt; in the temporally distinct waves of collagen gene expression that occur during larval development, sqt-1 mRNA appears to be synthesized during the second, or intermediate, stage, just very slightly earlier than sqt-3/col-1 and dpy-13; SQT-1 protein is detected in cuticle extracts from L2, L3, and L4 larvae, and from adults, but is not detected in extracts from L1 or dauer larvae; sqt-1 interacts genetically with a number of genes also required for normal cuticle and organismal morphology, e.g., rol-6 and lon-3, which also encode cuticular collagens. cuticle collagen SQT-1 B0495.4 B0495.4 nhx-2; B0495.4; 2H982; CE29549; NM_063213; WBGene00003730; WP:CE29549 nhx-2 encodes a sodium/proton exchanger expressed in the apical membranes of intestinal cells; NHX-2 is required for normally high growth rates, and for propagation or maintenance of the germline, NHX-2 is thought to prevent intracellular acidification by catalysing the electroneutral exchange of extracellular sodium for an intracellular proton. NA(+)/H(+) exchanger B0496.7 B0496.7 B0496.7; 4I208; CE06719; Q17522_CAEEL; WBGene00015216; WP:CE06719 B0507.6 B0507.6 B0507.6; 5J225; CE07765; WBGene00015223; WP:CE07765 B0507.10 B0507.8 B0507.10; 5J232; CE28875; WBGene00015227; WP:CE28875 B0511.10 B0511.10 eif-3.E; B0511.10; 1L218; CE17349; NM_060384; WBGene00001228; WP:CE17349 eif-3.E encodes the C. elegans ortholog of the translation initiation factor 3 subunit e (eIF3e/Int-6); by homology, EIF-3.E is predicted to be a component of three different protein complexes, the eIF3 translation initiation factor, the 26S proteasome, and the COP9 signalosome; such association suggests that EIF-3.E may serve as a regulatory factor that coordinates the translational and degradative activities of these various complexes; in C. elegans, large-scale RNAi screens indicate that eif-3.E is required for embryonic, larval, and germline development, as well as proper vulval morphogenesis. B0511.6 B0511.6 B0511.6; 1L203; CE26853; WBGene00015232; WP:CE26853 helicase B0511.8 B0511.8 tag-264; B0511.8; 1L214; CE28880; WBGene00015234; WBGene00044321; WP:CE28880 B0513.3 B0513.3 rpl-29; B0513.3; 4O647; CE15559; NM_070270; WBGene00004443; WP:CE15559 rpl-29 encodes a large ribosomal subunit L29 protein; by homology, RPL-29 is predicted to function in protein biosynthesis; in C. elegans, loss of rpl-29 function via RNA-mediated interference (RNAi) does not result in any obvious abnormalities. 60S ribosomal protein L29 B0554.1 B0554.1 B0554.1; 5A917; CE07773; WBGene00015254; WP:CE07773 B0564.1 B0564.1 tin-9.2; B0564.1; 4N865; CE20469; CE37950; NM_070119; WBGene00007201; WBGene00044083; WP:CE20469; WP:CE37950 The tin-9.2 locus encodes two disjoint protein products by alternative splicing, an ortholog of S. cerevisiae Tin9p (for which the locus is names) and a putative Rrp41 subunit of the exosomal 3'-5' exoribonuclease complex (termed simply B0564.1); TIN-9.2 protein is mitochondrial; TIN-9.2 is required for normal locomotion and development, for mitochondrial import of the ADP/ATP carrier, and (by inference) for import of many other inner mitochondrial membrane proteins; tin-9.2(RNAi) animals have abnormally small body and brood sizes, are sluggish and partly embryonic lethal, have defectively migrating distal tip cells (yielding defective somatic gonads), have an increased frequency of protruding vulvae, and fail to take up ADP/ATP carrier protein into isolated mitochondria. C01B10.8 C01B10.8 C01B10.8; 4H401; CE06739; Q17539_CAEEL; WBGene00015282; WP:CE06739 C01B12.1 C01B12.1 col-67; sqt-2; C01B12.1; 2A315; CE07789; NM_061234; WBGene00005017; WP:CE07789 sqt-2 encodes a collagen required for normal alae formation and body morphology; sqt-2 mutants exhibit a slightly dumpy phenotype and the bodies of mutants are helically twisted. cuticular collagen C01B7.7 C01B7.7 C01B7.7; 5J298; CE06731; WBGene00015277; WP:CE06731 C01G5.2 C01G5.2 tag-292; C01G5.2; 4H292; CE06748; WBGene00015304; WP:CE06748 C01G6.6 C01G6.6 tag-165; C01G6.6; 2J577; CE00868; CE32562; WBGene00006510; WP:CE00868; WP:CE32562 C01G6.6 encodes an ortholog of the human gene METHIONINE SYNTHASE REDUCTASE (MTRR), which when mutated leads to homocystinuria (OMIM:236270) C01G6.9 C01G6.9 C01G6.9; 2J584; CE00871; WBGene00007229; WP:CE00871 C01G8.6 C01G8.6 C01G8.6; 1F868; CE07807; WBGene00015313; WP:CE07807 C02A12.4 C02A12.4 lys-7; C02A12.4; 5D960; CE07828; NM_071571; WBGene00003096; WP:CE07828 lys-7 encodes an enzyme homologous to an antimicrobial lysozyme encoded by the LYS4 gene of the protozoan parasite Entamoeba histolytica; by homology, LYS-7 is predicted to function as an antimicrobial enzyme that hydrolyzes the 1,4-beta-linkages between N-acetyl-D-glucosamine and N-acetylmuramic acid in peptidoglycan heteropolymers of prokaryotic cell walls; in C. elegans, lys-7 expression is significantly upregulated in response to infection with the Gram-negative bacterium Serratia marcescens, indicating that LYS-7 likely plays a role in the innate immune response; constitutive expression of lys-7 mRNA is detected in the intestine and the intestinal valve cells. C02C2.3 C02C2.3 cup-4; C02C2.3; 3I957; CE30416; CUP4_CAEEL; NM_066309; WBGene00000845; WP:CE30416 The primary phenotype of cup-4 animals is an accumulation of secreted GFP in the pseudocoelom, suggesting a decrease in, or the absence of, endocytosis in coelomocytes. Acetylcholine receptor C02D5.1 C02D5.1 C02D5.1; 3J649; CE24778; WBGene00015335; WP:CE24778 Isovaleryl-CoA dehydrogenase C02E7.6 C02E7.6 C02E7.6; 5F397; CE07843; WBGene00015339; WP:CE07843 C02E7.7 C02E7.7 C02E7.7; 5F396; CE07844; WBGene00015340; WP:CE07844 C03G6.12 C03G6.12 nhr-149; C03G6.12; 5H828; CE07886; WBGene00015397; WP:CE07886 C4-type zinc finger protein C03G6.6 C03G6.6 C03G6.6; 5H837; CE36265; WBGene00015394; WP:CE36265 C04G2.6 C04G2.6 dis-3; tag-128; C04G2.6; 4K869; CE05214; NM_069434; WBGene00001001; WP:CE05214 S.pombe mitotic control protein like C05A9.1 C05A9.1 pgp-5; C05A9.1; CE05221; NM_077409; WBGene00003999; WP:CE05221; XL474 pgp-5 encodes a transmembrane protein that is a member of the P-glycoprotein subclass of the ATP-binding cassette (ABC) transporter superfamily; by homology, PGP-5 is predicted to function as an ATP-dependent efflux pump that protects C. elegans by exporting exogenous toxins; however, as loss of pgp-5 activity via large-scale RNAi screens does not result in any obvious abnormalities, the precise role of PGP-5 in C. elegans development and/or behavior is not yet known. p-glycoprotein C05C10.4 C05C10.4 C05C10.4; 2K223; CE17370; WBGene00007331; WP:CE17370 acid phosphatase C05C12.3 C05C12.3 gtl-1; tag-33; C05C12.3; 4M14; CE33754; NM_069710; WBGene00001795; WP:CE33754 gtl-1 encodes a TRPM subfamily member of the TRP channel family that affects the periodicity of the defecation cycle in combination with gon-2; expression includes the intestine. C05C8.2 C05C8.2 C05C8.2; 5H713; CE07920; WBGene00015461; WP:CE07920 C05C8.7 C05C8.7 phi-49; C05C8.7; 5H724; CE07925; WBGene00015464; WP:CE07925 mannose-6-phosphate isomerase C05C8.8 C05C8.8 C05C8.8; 5H732; CE07926; WBGene00015465; WP:CE07926 C05D10.3 C05D10.3 C05D10.3; 3H174; CE29170; WBGene00015479; WP:CE29170 VW02B12L.1 C05D12.6, VW02B12L.1 vha-6; VW02B12L.1; 2L726; CE18980; NM_064035; WBGene00006915; WP:CE18980 vha-6 encodes an ortholog of subunit a of the membrane-bound (V0) domain of vacuolar proton-translocating ATPase (V-ATPase); VHA-6 is orthologous to human ATP6N1A (OMIM:192130), ATP6V0A2, ATP6V0A4 (OMIM:605239, mutated in distal renal tubular acidosis), and TCIRG1 (OMIM:604592, mutated in osteopetrosis); VHA-6 is expressed in germline (P2 through Z3 cells until the comma stage), on the apical surface of postembryonic intestinal cells, and at the junction between pharynx and intestine; VHA-6 is required for growth and survival past the L1 larval stage; vha-6(RNAi) animals arrest as L1 larvae and remain alive (but do not grow) for one week; in S. cerevisiae, different V0 a-subunits (Stv1p and Vph1p) direct the assembly of V-ATPases to different membranes and organelles, suggesting that the profusion of such subunits in C. elegans (co-orthologous VHA-5, VHA-6, VHA-7, and six UNC-32 isoforms) may have a similar function; VHA-6 is predicted to capture protons from V-ATPase transmembrane rotor components and export the protons across the membrane. vacuolar ATP synthase C05E11.5 C05E11.5 amt-4; C05E11.5; CE27655; NM_076382; WBGene00000136; WP:CE27655; XF187 amt-4 encodes a member of the ammonium transporter protein family. ammonium transporter C06B3.7 C06B3.7 C06B3.7; 5O391; CE28430; WBGene00007366; WP:CE28430 C06E1.1 C06E1.1 C06E1.1; 3J695; CE00054; WBGene00015518; WP:CE00054; YKQ1_CAEEL C06E4.8 C06E4.8 C06E4.8; 4I42; CE03956; WBGene00015537; WP:CE03956 C06E7.1 C06E7.1 C06E7.1; 4G615; CE03957; CE32569; CE33515; CE37186; WBGene00015538; WP:CE03957; WP:CE32569; WP:CE33515; WP:CE37186 S-adenosylmethionine synthetase C06E7.3 C06E7.3 C06E7.3; 4G610; CE03959; CE33517; WBGene00015540; WP:CE03959; WP:CE33517 S-adenosylmethionine synthetase C06E7.6 C06E7.6 spe-27; C06E7.6; 4G630; CE03962; NM_068474; WBGene00004973; WP:CE03962 spe-27 encodes a novel, hydrophilic protein; spe-27 is required for sperm activation (morphogenesis of sperm to crawling spermatozoa), and may act in a common signaling pathway with spe-12 and spe-29 to initiate sperm activation, based on genetic analysis. C06E8.5 C06E8.5 C06E8.5; 3I92; CE00801; WBGene00015544; WP:CE00801 bacterial permeability-increasing protein C06G1.1 C06G1.1 C06G1.1; CE27054; WBGene00015545; WP:CE27054; XR251 C06G3.11 C06G3.11 tin-9.1; C06G3.11; 4H808; CE07987; CE33518; WBGene00006572; WP:CE07987; WP:CE33518; tim9a; tim9b tin-9 encodes a member of the Tim10/DDP family of zinc finger proteins, a family of proteins typically involved in mitochondrial protein import, and localized to the mitochondrial intermembrane space. C06G4.5 C06G4.5 C06G4.5; 3J80; CE38997; WBGene00015559; WP:CE38997 G-protein coupled receptor C06G8.1 C06G8.1 C06G8.1; 4L544; CE05229; WBGene00007384; WP:CE05229 C07D10.1 C07D10.1 C07D10.1; 2H689; CE27056; WBGene00015566; WP:CE27056 C07D10.4 C07D10.4 nas-7; C07D10.4; 2H690; CE34663; NM_063151; WBGene00003526; WP:CE34663 Zinc metalloprotease C07D10.5 C07D10.5 C07D10.5; 2H673; CE36628; WBGene00015569; WP:CE36628 C07G3.9 C07G3.9 ugt-64; C07G3.9; 5D982; CE08000; WBGene00015577; WP:CE08000 7TM chemoreceptor, ugt family C08A9.1 C08A9.1 sod-3; C08A9.1; CE08002; MnSOD; NM_078363; WBGene00004932; WP:CE08002; XR707 sod-3 encodes a iron/manganese superoxide dismutase, predicted to be mitochondrial, that might defend against oxidative stress and promote normal lifespan; sod-3 mRNA levels are diminished by mutation of daf-16, and heterologously expressed SOD-3 in E. coli protects against methyl viologen-induced oxidative stress. superoxide dismutase C08E3.10 C08E3.10 fbxa-158; C08E3.10; 2B912; CE34666; CE39672; WBGene00015602; WP:CE34666; WP:CE39672 This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins; this gene's encoded protein also contains an FTH/DUF38 motif, which may also mediate protein-protein interaction. C08E3.11 C08E3.11 fbxa-159; C08E3.11; 2B914; CE08014; WBGene00015603; WP:CE08014 C08E3.12 C08E3.12 fbxa-160; C08E3.12; 2B916; CE08015; WBGene00015604; WP:CE08015 C08E3.4 C08E3.4 fbxa-161; C08E3.4; 2B898; CE32119; WBGene00015596; WP:CE32119 C08E3.5 C08E3.5 fbxa-162; C08E3.5; 2B900; CE34667; WBGene00015597; WP:CE34667 This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins; this gene's encoded protein also contains an FTH/DUF38 motif, which may also mediate protein-protein interaction. C08E3.6 C08E3.6 fbxa-163; C08E3.6; 2B902; CE08009; WBGene00015598; WP:CE08009 This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins; this gene's encoded protein also contains an FTH/DUF38 motif, which may also mediate protein-protein interaction. C08E3.7 C08E3.7 fbxa-164; C08E3.7; 2B906; CE08010; WBGene00015599; WP:CE08010 This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins; this gene's encoded protein also contains an FTH/DUF38 motif, which may also mediate protein-protein interaction. C08E3.8 C08E3.8 fbxa-165; C08E3.8; 2B908; CE08011; WBGene00015600; WP:CE08011 This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins; this gene's encoded protein also contains an FTH/DUF38 motif, which may also mediate protein-protein interaction. C08E8.4 C08E8.4 C08E8.4; 5S845; CE17378; WBGene00007440; WP:CE17378 C08F1.5 C08F1.5 math-4; C08F1.5; 2C70; CE31772; CE39130; WBGene00015609; WP:CE31772; WP:CE39130 C08F11.3 C08F11.3 C08F11.3; 4O385; CE35387; WBGene00007452; WP:CE35387 C08F11.4 C08F11.4 sru-21; C08F11.4; 4O395; CE34524; NM_070229; WBGene00005684; WP:CE34524 C09B8.5 C09B8.5 C09B8.5; CE02465; WBGene00015624; WP:CE02465; XG640 C09D4.5 C09D4.5 rpl-19; C09D4.5; 1G54; CE08034; NM_059207; WBGene00004431; WP:CE08034 rpl-19 encodes a large ribosomal subunit L19 protein. 60S ribosomal protein L19 C09E8.3 C09E8.3 mlt-10; C09E8.3; 2A841; CE19349; WBGene00015646; WP:CE19349 C09G1.1 C09G1.1 pqn-11; C09G1.1; CE37313; NM_078217; Q17862_CAEEL; WBGene00004103; WP:CE37313; XQ582 PQN-11 encodes an unfamiliar protein with a glutamine/asparagine-rich domain that is dispensable for viability and gross morphology. C09H5.2 C09H5.2 C09H5.2; 5I559; CE24797; CE32578; WBGene00015660; WP:CE24797; WP:CE32578 ATPase C10G8.3 C10G8.3 C10G8.3; 5F791; CE20494; WBGene00015682; WP:CE20494 C10H11.6 C10H11.6 ugt-26; C10H11.6; 1F291; CE30597; WBGene00015695; WP:CE30597 7TM chemoreceptor, ugt family C11H1.5 C11H1.1 C11H1.5; CE37315; WBGene00007530; WP:CE37315; XO918 C13A2.1 C13A2.1 C13A2.1; 5H763; CE35231; WBGene00015718; WP:CE35231 C13A2.10 C13A2.10 C13A2.10; 5H748; CE08121; WBGene00015726; WP:CE08121 C13A2.11 C13A2.11 C13A2.11; 5H754; CE36783; WBGene00015727; WP:CE36783 C13A2.2 C13A2.2 C13A2.2; 5H759; CE08114; WBGene00015719; WP:CE08114 C13A2.3 C13A2.3 C13A2.3; 5H757; CE40248; WBGene00015720; WP:CE40248 C13A2.4 C13A2.4 C13A2.4; 5H753; CE08116; WBGene00015721; WP:CE08116 C13A2.5 C13A2.5 C13A2.5; 5H751; CE08117; WBGene00015722; WP:CE08117 C13A2.6 C13A2.6 C13A2.6; 5H747; CE08118; WBGene00015723; WP:CE08118 C13A2.7 C13A2.7 C13A2.7; 5H745; CE35233; WBGene00015724; WP:CE35233 C13A2.9 C13A2.9 C13A2.9; 5H742; CE08120; WBGene00015725; WP:CE08120 C14A4.1 C14A4.1 tag-242; C14A4.1; CE02138; DOHH_CAEEL; WBGene00007555; WP:CE02138 C14A4.14 C14A4.2 C14A4.14; 2K875; CE24801; WBGene00007564; WP:CE24801 C14A4.9 C14A4.9 C14A4.9; 2K891; CE02150; WBGene00007560; WP:CE02150 C14B9.7 C14B9.7 rpl-21; C14B9.7; 3J218; CE00078; NM_066373; RL21_CAEEL; WBGene00004433; WP:CE00078 rpl-21 encodes a large ribosomal subunit L21 protein; by homology, RPL-21 is predicted to function in protein biosynthesis; in C. elegans, RPL-21 activity is required for embryonic and germline development. Ribosomal protein L21 C14C11.7 C14C11.7 C14C11.7; 5G146; CE06826; WBGene00015769; WP:CE06826 C14C6.4 C14C6.4 nhr-155; C14C6.4; 5B19; CE08159; WBGene00015758; WP:CE08159 zinc finger protein C14F11.6 C14F11.6 C14F11.6; CE02482; WBGene00015781; WP:CE02482; XG856 DTDP-4-dehydrorhamnose 3,5-epimerase (RFBC gene) C14F5.2 C14F5.2 zig-3; C14F5.2; CE01781; NM_076935; WBGene00006980; WP:CE01781; XI549 IG-like C2-type domain C15A11.2 C15A11.2 C15A11.2; 1H963; CE08170; WBGene00007597; WP:CE08170 C15B12.1 C15B12.1 C15B12.1; CE29665; WBGene00015783; WP:CE29665; XH97 sarcosine oxidase C15H11.5 C15H11.5 set-31; tag-338; C15H11.5; 5O899; CE08182; WBGene00007615; WP:CE08182 C15H11.9 C15H11.9 C15H11.9; 5O906; CE08186; WBGene00007617; WP:CE08186 Human HA0609 protein like C15H7.4 C15H7.4 C15H7.4; 3K742; CE00082; WBGene00007611; WP:CE00082 C15H9.1 C15H9.1 nnt-1; C15H9.1; CE08176; NM_076627; WBGene00003778; WP:CE08176; XG745 nnt-1 encodes a proton-pumping nicotinamide nucleotide transhydrogenase predicted to be mitochondrial. NAD(P) transhydrogenase, mitochondrial C16A11.3 C16A11.3 C16A11.3; 2E523; CE19353; WBGene00015816; WP:CE19353 protein kinase C16A3.3 C16A3.3 C16A3.3; 3H477; CE27690; NM_065997; WBGene00015808; WP:CE27690 C16A3.6 C16A3.6 C16A3.6; 3H469; CE04006; WBGene00015811; WP:CE04006 C16A3.9 C16A3.9 rps-13; C16A3.9; 3H464; CE04009; NM_065992; WBGene00004482; WP:CE04009 rps-13 encodes a small ribosomal subunit S13 protein; by homology, RPS-13 is predicted to function in protein biosynthesis; in C. elegans, RPS-13 activity is required for embryonic and germline development. 40S ribosomal protein S13 C16B8.3 C16B8.3 C16B8.3; CE04013; Q18043_CAEEL; WBGene00015823; WP:CE04013; XE586 C16C8.2 C16C8.2 C16C8.2; 2D722; CE23553; WBGene00015841; WP:CE23553 peroxidase precursor C16E9.1 C16E9.1 C16E9.1; CE35403; WBGene00015865; WP:CE35403; XH561 C17C3.12 C17C3.12 acdh-2; C17C3.12; CE29175; CE29176; CE34697; NM_062665; NM_062666; NM_062667; WBGene00015894; WP:CE29175; WP:CE29176; WP:CE34697 acdh-2 encodes a short-chain acyl-CoA dehydrogenase; ACDH-2 is predicted to be a mitochondrial enzyme that catalyzes the first step of fatty acid beta-oxidation and thus plays a key role in energy production; steady-state acdh-2 mRNA levels are under the control of the MDT-15 mediator complex subunit; in addition, gene expression studies indicate that acdh-2 expression is downregulated in fasted animals; loss of acdh-2 activity via large-scale RNAi experiments does not result in any obvious defects. C17C3.3 C17C3.3 C17C3.3; 2F853; CE34698; WBGene00015889; WP:CE34698 C17G1.6 C17G1.6 nas-37; C17G1.6; CE31417; CE38034; WBGene00003553; WP:CE31417; WP:CE38034; XK564 nas-37 encodes a Astacin-class metalloprotease required for full ecdysis that is expressed in hypodermal cells 4 hours before each ecdysis; NAS-37 protein has an N-terminal signal sequence followed by an Astacin protease domain and three protein-binding domains (EGF-like, CUB, and thrombospondin); NAS-37 accumulates in anterior cuticle, being shed with it after ecdysis; nas-37 mutants fail to complete anterior ecdysis at each molt; nas-37(ox196) mutations alter an evolutionarily invariant histidine residue yet are phenotypically indistinguishable from null mutations, consistent with the hypothesis that NAS-37 encodes a functional protease; NAS-37 orthologs are found in other nematodes such as Brugia malayi. C17G10.2 C17G10.2 C17G10.2; 2F885; CE29583; WBGene00015916; WP:CE29583 TPR domain C17H1.1 C17H1.1 C17H1.1; 1N708; WBGene00007654 C17H1.2 C17H1.2 C17H1.2; 1N688; CE15624; WBGene00007655; WP:CE15624 C17H1.3 C17H1.3 C17H1.3; 1N691; CE15625; WBGene00007656; WP:CE15625 C17H1.7 C17H1.7 C17H1.7; 1N722; CE15629; WBGene00007660; WP:CE15629 C17H12.14 C17H12.14 pes-6; vha-8; C17H12.14; 4H557; CE19362; NM_068639; WBGene00006917; WP:CE19362 vha-8 encodes an ortholog of subunit E of the cytoplasmic (V1) domain of vacuolar proton-translocating ATPase (V-ATPase); VHA-8 is a predicted cytosolic stator (stalk) component; VHA-8 is required for embryonic and larval viability, for ovulation, and for receptor-mediated endocytosis of yolk protein; VHA-8 is highly expressed in the cytoplasm of excretory canals throughout development, and in the stacked apical plasma membrane sheets of syncytial hypodermal cells; general levels of VHA-8 protein are very low in embryos but increase strongly after hatching; vha-8 mutants show necrotic cell death in hypodermis and intestine, paralleling the role of VHA-12 and other V-ATPase subunits in neuronal necrosis; VHA-8 is dispensable for alae formation, like the V1 subunit VHA-13, but not like the V0 subunits VHA-1 and VHA-4. ATPase C18A11.3 C18A11.3 C18A11.3; CE39563; WBGene00015949; WP:CE39563; XI683 C18A3.3 C18A3.3 C18A3.3; 2G7; CE28890; WBGene00015941; WP:CE28890 C18B2.5 C18B2.5 C18B2.5; CE04044; CE30872; Q8MQD2_CAEEL; WBGene00015956; WP:CE04044; WP:CE30872; XE226 C18D4.6 C18D4.6 C18D4.6; 5S16; CE32310; CE32311; CE36469; WBGene00007675; WP:CE32310; WP:CE32311; WP:CE36469 C18E9.6 C18E9.6 C18E9.6; 2J262; CE05298; WBGene00007686; WP:CE05298 C18G1.5 C18G1.5 hil-4; C18G1.5; H1.4; 5F233; CE17421; NM_071876; WBGene00001855; WP:CE17421 histone H1 C18H7.3 C18H7.3 col-102; C18H7.3; 4B353; CE17428; NM_067556; WBGene00000676; WP:CE17428 cuticular collagen C18H7.9 C18H7.9 C18H7.9; 4B352; CE17434; WBGene00015999; WP:CE17434 C23G10.11 C23G10.11 C23G10.11; 3H304; CE04057; WBGene00016017; WP:CE04057 C23G10.6 C23G10.6 C23G10.6; 3H282; CE40438; WBGene00016013; WP:CE40438 UDP-glucosyltransferase C23H4.2 C23H4.2 C23H4.2; CE26673; WBGene00007691; WP:CE26673; XM841 carboxyesterase C23H4.6 C23H4.6 C23H4.6; CE08332; WBGene00007694; WP:CE08332; XM859 Yeast RAD18 protein like C24A3.6 C24A3.5, C24A3.6 mah-2; twk-18; unc-110; C24A3.5; C24A3.6; CE24811; WBGene00006672; WP:CE24811; XJ611 twk-18 encodes one of 44 C. elegans TWK (two-P domain K+) potassium channel subunits that contain two pore-forming domains and four transmembrane domains; TWK-18 was originally defined by gain-of-function mutations that result in embryonic lethality at the two-fold stage, locomotion defects, longer than normal body length, abnormal egg-laying, and temperature-sensitive paralysis; as loss of TWK-18 function via reversion or RNA-mediated interference does not result in any abnormalities, TWK-18 likely functions redundantly with other TWK channels; TWK-18 can function as an outwardly rectifying K+ channel, and is activated by temperature increases, thus making it a temperature-gated channel; TWK-18 is expressed in body wall muscle. potassium channel protein C24A3.6 C24A3.5, C24A3.6 mah-2; twk-18; unc-110; C24A3.5; C24A3.6; CE24811; WBGene00006672; WP:CE24811; XJ611 twk-18 encodes one of 44 C. elegans TWK (two-P domain K+) potassium channel subunits that contain two pore-forming domains and four transmembrane domains; TWK-18 was originally defined by gain-of-function mutations that result in embryonic lethality at the two-fold stage, locomotion defects, longer than normal body length, abnormal egg-laying, and temperature-sensitive paralysis; as loss of TWK-18 function via reversion or RNA-mediated interference does not result in any abnormalities, TWK-18 likely functions redundantly with other TWK channels; TWK-18 can function as an outwardly rectifying K+ channel, and is activated by temperature increases, thus making it a temperature-gated channel; TWK-18 is expressed in body wall muscle. potassium channel protein C24B9.9 C24B9.9 dod-3; C24B9.9; 5D208; CE17451; NM_071341; WBGene00016052; WP:CE17451 C24G6.7 C24G6.7 grl-1; C24G6.7; 5G10; CE17463; NM_072059; WBGene00001710; WP:CE17463 grl-1 encodes a hedgehog-like protein, with an N-terminal signal sequence, a central proline-rich region, and a C-terminal Ground-like (Grl) domain; GRL-1 is expressed in intestine, neurons, and larval arcade cells; the Grl domain is predicted to form a cysteine-crosslinked protein involved in intercellular signalling, and it has subtle similarity to the N-terminal Hedge domain of HEDGEHOG proteins. C24H12.4 C24H12.4 C24H12.4; 2A705; CE27728; CE29675; WBGene00016073; WP:CE27728; WP:CE29675 helicase C25A1.10 C25A1.10 dao-5; C25A1.10; 1K764; CE08376; CE38279; WBGene00000931; WP:CE08376; WP:CE38279 dao-5 encodes a predicted nucleolar phosphoprotein related to Saccharomyces cerevisiae SRP40 and the vertebrate Nopp140 proteins that may play a role in rRNA gene transcription and nucleolar structural organization; dao-5 expression is negatively regulated by the DAF-2/insulin-like receptor and positively regulated by the DAF-16/fork-head transcription factor, suggesting that dao-5 may be involved in life-span determination; dao-5 is strongly expressed in dauer larvae. C25A1.7 C25A1.7 irs-2; C25A1.7; 1K759; CE35957; NM_060279; WBGene00002153; WP:CE35957 irs-2 encodes a predicted mitochondrial isoleucyl-tRNA synthetase (IleRS), a class I aminoacyl-tRNA synthetase that catalyzes the attachment of isoleucine to its cognate tRNA and is thus required for protein biosynthesis; loss of irs-2 activity via RNA-mediated interference (RNAi) in the hypersensitive rrf-3 strain results in thin animals who grow at slower rates than wild type, indicating that IRS-2 plays a role in regulation of postembryonic growth. isoleucyl-tRNA synthetase (mitochondrial) C25A11.4 C25A11.3 ajm-1; jam-1; C25A11.4; CE27083; CE27084; CE27085; CE30874; CE39677; NM_077135; NM_077136; NM_077137; NM_171966; WBGene00000100; WP:CE27083; WP:CE27084; WP:CE27085; WP:CE30874; WP:CE39677; XJ731 ajm-1 encodes a member of the apical junction molecule class that is required for correct elongation of the C. elegans embryo; AJM-1 contains a coiled-coil motif; AJM-1 binds DLG-1 in vitro, in yeast two-hybrid assays, and in vivo; AJM-1 is mislocalized in a dlg-1(RNAi) background; LET-413 is required for rapid confinement of DLG-1 and AJM-1 to a narrow apical region in C. elegans epithelia; CLC-1 colocalizes with AJM-1; vab-9 mutations enhance the adhesion defects of ajm-1 mutants; ajm-1 is expressed at the apical borders of all epithelia. C25E10.12 C25E10.12 C25E10.12; 5J542; CE06874; WBGene00016101; WP:CE06874 C25E10.2 C25E10.2 cyp-33B1; C25E10.2; 5J521; CE35248; NM_072941; WBGene00016092; WP:CE35248 cytochrome P450 C25F6.3 C25F6.3 C25F6.3; CE38489; WBGene00016103; WP:CE38489; XG89 The C25F6.3 gene encodes an ortholog of the human gene DIHYDROPYRIMIDINE DEHYDROGENASE (DPYD), which when mutated leads to thymine-uraciluria (OMIM:274270). C25H3.10 C25H3.10 C25H3.10; 2F988; CE27090; CE37612; WBGene00016119; WP:CE27090; WP:CE37612 C26C6.3 C26C6.3 nas-36; C26C6.3; 1I107; CE38281; NM_059708; WBGene00003552; WP:CE38281 zinc metalloprotease C26C6.4 C26C6.4 C26C6.4; 1I111; CE05313; CE40020; WBGene00007739; WP:CE05313; WP:CE40020 C26E1.2 C26E1.2 C26E1.2; 5N789; CE36581; WBGene00007748; WP:CE36581 C26F1.1 C26F1.1 C26F1.1; 5I267; CE32807; CE35249; WBGene00016146; WP:CE32807; WP:CE35249 C26F1.4 C26F1.4 rps-30; C26F1.4; 5I257; CE06878; NM_072606; WBGene00004499; WP:CE06878 rps-30 encodes two proteins, a small ribosomal subunit S30 protein and ubiquitin, which is cleaved from the ribosomal protein posttranslationally; by homology, S30 is predicted to function in protein biosynthesis and ubiquitin in protein degradation; in C. elegans, loss of rps-30 function via RNA-mediated interference (RNAi) does not result in any obvious abnormalities. ribosomal protein/ubiquitin-like protein C27A2.2 C27A2.2 rpl-22; C27A2.2; 2F347; CE04102; CE29188; NM_062531; NM_062532; WBGene00004434; WP:CE04102; WP:CE29188 rpl-22 encodes a large ribosomal subunit L22 protein; by homology, RPL-22 is predicted to function in protein biosynthesis; in C. elegans, RPL-22 activity is broadly required for embryonic and germline development, as well as normal body coloration, morphology, and postembryonic growth rates. C27A7.2 C27A7.2 C27A7.2; 5M619; CE31886; WBGene00007754; WP:CE31886 C27C7.1 C27C7.1 C27C7.1; 1M31; CE19705; WBGene00007766; WP:CE19705 C27C7.2 C27C7.2 C27C7.2; 1M20; CE18533; WBGene00007767; WP:CE18533 C27C7.3 C27C7.3 nhr-74; C27C7.3; 1M19; CE34263; NM_060518; WBGene00003664; WP:CE34263 nuclear hormone receptor C27C7.4 C27C7.4 nhr-73; C27C7.4; 1M22; CE18535; NM_060520; Q9XVC8_CAEEL; WBGene00003663; WP:CE18535 nhr-73 encodes a member of the superfamily of nuclear receptors, which is one of the most abundant class of transcriptional regulators; nuclear receptors have a well conserved DNA binding domain and a less conserved C-terminal ligand binding domain; expression studies using GFP fusions indicate that nhr-73 is expressed exclusively in lateral seam cells; expression of nhr-73 is seen in early embryonic lateral hypodermal cells and continues to persist in the daughter cell that continues to divide and is lost in the daughter cell that differentiates; nhr-73 expression is diminished by knocking down genes (via RNA interference) that are involved in seam cell development like elt-5 and ceh-16/engrailed. Zinc finger, C4 type (two domains) C27C7.8 C27C7.8 nhr-259; C27C7.8; 1M25; CE18538; WBGene00007770; WP:CE18538 C27D8.1 C27D8.1 C27D8.1; 4N483; CE18539; WBGene00007777; WP:CE18539 serine/threonine kinase C27H5.2 C27H5.2 C27H5.2; 2H449; CE27098; CE29191; CE32150; CE32151; Q18266_CAEEL; WBGene00016172; WP:CE27098; WP:CE29191; WP:CE32150; WP:CE32151 C27H5.5 C27H5.5 col-36; C27H5.5; 2H458; CE06893; NM_063086; WBGene00000613; WP:CE06893 col-36 encodes a collagen protein; expressed during the L1 to L2 and L2 to dauer larval stage molts. cuticular collagen C27H5.7 C27H5.7 dyf-13; C27H5.7; CE06894; CE31320; WBGene00001129; WP:CE06894; WP:CE31320 dyf-13 encodes a ciliary protein, belonging to a conserved but unfamiliar protein family, that is required for cilial function and formation, undergoes IFT, and might represent a core component of the OSM-3 kinesin IFT pathway; dyf-13 is expressed in AWB neurons; dyf-13 mutations affect morphology of the amphid and phasmid neurons, chemotaxis, dauer formation, growth, male mating, and hermaphrodite brood size; dyf-13 requires DAF-19 for its transcription. C29E4.1 C29E4.1 col-90; C29E4.1; 3J39; CE00083; NM_066328; WBGene00000665; WP:CE00083 Cuticle collagen C29E6.5 C29E6.5 nhr-43; C29E6.5; 4M667; CE05336; NM_069853; WBGene00003633; WP:CE05336 nhr-43 is predicted to encode a nuclear hormone receptor (NHR); the primary sequence of nhr-43 reveals that it has a leucine instead of a methionine that is conserved within the NHR superfamily at the carboxyl boundary of the DNA-binding domain. Zinc finger, C4 type (two domains) C29F3.2 C29F3.2 wrt-8; C29F3.2; 5P822; CE29200; NM_074404; WBGene00006954; WP:CE29200; WRT8_CAEEL wrt-8 encodes a hedgehog-like protein, with (from N- to C-terminus) a signal sequence, a Wart domain, an short region of low-complexity sequence, and a Hint/Hog domain; WRT-8 is strongly expressed in hypodermal syncytia hyp6-hyp10 throughout life, and in in 12 subventral P cells and their descendants from 3-fold embryo to L2 larva stages; the Hint/Hog domain is predicted to cut WRT-8 into two halves and then covalently link cholesterol to the C-terminus of the Wart domain; the Wart domain is predicted to form a cysteine-crosslinked protein involved in intercellular signalling, and it has subtle similarity to the N-terminal Hedge domain of HEDGEHOG proteins; WRT-8 has no obvious function in RNAi assays. Hint module C29F3.3 C29F3.3 C29F3.3; 5P826; CE08437; WBGene00007804; WP:CE08437 C29F3.5 C29F3.5 C29F3.5; 5P828; CE08439; WBGene00007806; WP:CE08439 Lectin C-type domain C29F3.7 C29F3.7 C29F3.7; 5P837; CE31888; CE40917; WBGene00007807; WP:CE31888; WP:CE40917 C29F4.1 C29F4.1 col-125; C29F4.1; 4L991; CE03038; NM_069706; WBGene00000699; WP:CE03038 collagen C29F7.2 C29F7.2 C29F7.2; CE35414; WBGene00007811; WP:CE35414; XO35 C29F7.3 C29F7.3 C29F7.3; CE08444; WBGene00007812; WP:CE08444; XO38 uridylate kinase C29F9.10 C29F9.10 fbxa-57; C29F9.10; 3A724; CE39328; WBGene00016224; WP:CE39328 C29F9.11 C29F9.11 fbxa-58; C29F9.11; 3A726; CE08459; WBGene00016225; WP:CE08459 C29F9.13 C29F9.13 nhr-280; C29F9.13; 3A746; CE08461; WBGene00016227; WP:CE08461 C29F9.2 C29F9.2 C29F9.2; 3A339; 3A749; CE08450; WBGene00016217; WP:CE08450 C29F9.3 C29F9.3 C29F9.3; 3A743; CE28896; CE30623; CE30624; WBGene00016218; WP:CE28896; WP:CE30623; WP:CE30624 C29F9.4 C29F9.4 C29F9.4; CE39229; WBGene00016219; WP:CE39229 C30E1.6 C30E1.6 C30E1.6; CE35415; WBGene00016255; WP:CE35415; XR527 C30G12.2 C30G12.2 C30G12.2; 2H581; CE25799; WBGene00016274; WP:CE25799 Alcohol dehydrogenase C31A11.5 C31A11.5 C31A11.5; 5Q785; CE15656; WBGene00007833; WP:CE15656 C31B8.12 C31B8.12 C31B8.12; 5D402; CE35251; WBGene00016285; WP:CE35251 C31B8.4 C31B8.4 C31B8.4; 5D373; CE08484; WBGene00016281; WP:CE08484 C31H5.4 C31H5.4 C31H5.4; 1J618; CE17484; NM_060029; WBGene00007855; WP:CE17484 C31H5.5 C31H5.5 C31H5.5; 1J624; CE17485; WBGene00007856; WP:CE17485 C32B5.9 C32B5.9 C32B5.9; 2B247; CE08517; WBGene00016302; WP:CE08517 C32D5.1 C32D5.1 C32D5.1; 2G635; CE34726; WBGene00016310; WP:CE34726 C32E12.3 C32E12.3 osr-1; C32E12.3; 1F768; CE30495; NM_059144; WBGene00016329; WP:CE30495 C32E8.2 C32E8.2 rpl-13; C32E8.2; 1E357; CE08526; CE33562; WBGene00004425; WP:CE08526; WP:CE33562 rpl-13 encodes a large ribosomal subunit L13 protein. C32H11.10 C32H11.10 dod-21; C32H11.10; 4N699; CE19717; NM_070071; WBGene00007873; WP:CE19717 C32H11.12 C32H11.12 dod-24; C32H11.12; 4N704; CE19718; NM_070073; WBGene00007875; WP:CE19718 C32H11.4 C32H11.4 C32H11.4; 4N687; CE19711; WBGene00007867; WP:CE19711 C32H11.9 C32H11.9 C32H11.9; 4N698; CE19716; WBGene00007872; WP:CE19716 C33A12.2 C33A12.2 nlp-35; C33A12.2; 4K284; CE05348; WBGene00007881; WP:CE05348 C33A12.7 C33A12.7 C33A12.7; 4K272; CE15664; WBGene00007886; WP:CE15664 C33D9.8 C33D9.8 C33D9.8; 4J548; CE03048; WBGene00007901; WP:CE03048 C34B2.4 C34B2.4 C34B2.4; 1L246; CE16892; WBGene00016389; WP:CE16892 C34D1.1 C34D1.1 C34D1.1; 5N704; CE08569; WBGene00007929; WP:CE08569 DM DNA binding domain C34F11.3 C34F11.3 C34F11.3; 2F499; CE33034; CE33035; CE39332; WBGene00016415; WP:CE33034; WP:CE33035; WP:CE39332 AMP deaminase C34H4.3 C34H4.3 tag-244; C34H4.3; 4C315; CE27820; WBGene00016426; WBGene00044073; WP:CE27820 C34H4.4 C34H4.4 col-107; C34H4.4; 4C313; CE20539; CE27821; NM_067693; NM_182305; WBGene00000681; WP:CE20539; WP:CE27821 cuticular collagen C35A5.6 C35A5.6 C35A5.6; 5K989; CE05364; CE40026; WBGene00007950; WP:CE05364; WP:CE40026 C35E7.9 C35E7.9 C35E7.9; 1L383; CE17522; WBGene00016461; WP:CE17522 C36A4.1 C36A4.1 cyp-25A1; C36A4.1; 3E921; CE37711; NM_065374; WBGene00007963; WP:CE37711 cytochrome P450 C36B7.5 C36B7.5 C36B7.5; CE25806; CE27832; WBGene00016468; WP:CE25806; WP:CE27832; XH708 type-I thrombospondin TSR repeats C37A2.7 C37A2.7 C37A2.7; 1H366; CE30433; RLA2_CAEEL; WBGene00016493; WP:CE30433 ribosomal protein C37A5.8 C37A5.8 fipr-24; C37A5.8; 1O751; CE17532; WBGene00007992; WP:CE17532 Y66A7A.6 C37G2.6, Y66A7A.6, Y66a7a.6 gly-8; Y66A7A.6; 3M717; CE15691; NM_067103; WBGene00001633; WP:CE15691 gly-8 encodes a predicted transmembrane polypeptide N-acetylgalactosaminyl transferase (ppGaNTase) similar to the essential Drosophila ppGaNTase encoded by Pgant35A; by homology, GLY-8 is predicted to function as a Golgi enzyme that catalyzes transfer of N-acetylgalactosamine to serine and threonine-containing acceptor peptides, thus initiating mucin-type O-glycosylation; as loss of gly-8 activity via large-scale RNAi screens does not result in any obvious abnormalities, the precise role of GLY-8 in C. elegans development and/or behavior is not yet known. Glycosyl transferases C37H5.2 C37H5.2 C37H5.2; 5F327; CE30737; WBGene00016506; WP:CE30737 C37H5.5 C37H5.5 C37H5.5; 5F313; CE29708; WBGene00016508; WP:CE29708 C37H5.8 C37H5.8 hsp-6; mot-2; C37H5.8; 5F304; CE08631; NM_071890; WBGene00002010; WP:CE08631 hsp-6 encodes a mitochondrial-specific chaperone that is a member of the DnaK/Hsp70 superfamily of molecular chaperones; hsp-6 is believed to be involved in the mitochondrial unfolded protein response, as hsp-6 expression, normally broadly detected from the L1 larval through adult stages of development, is greatly increased in response to treatments that disrupt mitochondrial protein handling; loss of hsp-6 activity via RNAi results in severe growth defects with arrest at embryonic and early larval stages of development. heat shock 70 protein C38D9.2 C38D9.2 C38D9.2; 5S51; CE19728; WBGene00008010; WP:CE19728 C38D9.4 C38D9.4 fbxa-133; C38D9.4; 5S63; CE19730; WBGene00008012; WP:CE19730 C39E9.10 C39E9.10 C39E9.10; 4N853; CE05393; WBGene00008033; WP:CE05393 tetracycline resistance protein like C40C9.4 C40C9.4 C40C9.4; CE05401; WBGene00008037; WP:CE05401; XO269 C40D2.3 C40D2.3 math-21; C40D2.3; 2C279; CE19375; WBGene00016556; WP:CE19375 C40H1.4 C40H1.4 elo-4; C40H1.4; 3K420; CE00112; NM_066655; WBGene00001242; WP:CE00112 The elo-4 gene encodes a paralog of elo-1 and elo-2, each of which encodes a polyunsaturated fatty acid (PUFA) elongase; its function in vivo is unknown. Yeast hypothetical YCR34W C40H5.1 C40H5.1, D1053.5 nspa-9; C40H5.1; CE08649; WBGene00043187; WP:CE08649 C42D4.3 C42D4.3 C42D4.3; 4H945; CE04191; WBGene00016596; WP:CE04191 C43C3.1 C43C3.1 ifp-1; C43C3.1; CE01523; IF E1; IFP1_CAEEL; NM_077227; WBGene00002067; WP:CE01523; XK296 ifp-1 encodes a nonessential intermediate filament protein; IFP-1 is predicted to function as a structural component of the cytoskeleton; IFP-1 has no obvious function in RNAi assays. intermediate filament protein C43D7.4 C43D7.4 C43D7.4; 5T794; CE18548; WBGene00008067; WP:CE18548 C43D7.5 C43D7.5 sdz-6; C43D7.5; 5T793; CE18549; WBGene00008068; WP:CE18549 C43E11.9 C43E11.9 C43E11.9; 1E836; CE08687; WBGene00016607; WP:CE08687 C43F9.4 C43F9.4 C43F9.4; 4L352; CE35429; WBGene00008072; WP:CE35429 C43G2.3 C43G2.3 C43G2.3; 4H343; CE36277; WBGene00016612; WP:CE36277 C44B7.8 C44B7.8 pmp-1; C44B7.8; 2H172; CE02546; NM_063006; WBGene00004058; WP:CE02546 ATP-binding protein C44C1.1 C44C1.1 C44C1.1; CE35432; WBGene00016641; WP:CE35432; XB601 C44C1.5 C44C1.5 C44C1.5; CE04215; CE33918; WBGene00016644; WP:CE04215; WP:CE33918; XB594 C44C10.11 C44C10.2 C44C10.11; CE37713; WBGene00043985; WP:CE37713; XM328 C44E4.4 C44E4.4 C44E4.4; 1F203; CE08718; WBGene00016653; WP:CE08718 RNA-binding protein C44H9.7 C44H9.7 C44H9.7; 5N334; CE05423; CE36109; WBGene00008102; WP:CE05423; WP:CE36109 C45B2.1 C45B2.1 C45B2.1; CE27853; WBGene00016658; WP:CE27853; XG705 C45B2.2 C45B2.2 C45B2.2; CE02552; WBGene00016659; WP:CE02552; XG703 C45E5.1 C45E5.1 C45E5.1; 4G507; CE34756; WBGene00016664; WP:CE34756 C45G7.5 C45G7.6 cdh-10; C45G7.5; 4D204; CE38044; NM_067803; WBGene00000402; WP:CE38044 cdh-10 encodes a member of the cadherin superfamily. C45H4.17 C45H4.17 cyp-33C2; C45H4.17; Y5H2B.F; 5C663; CE25818; NM_071193; WBGene00016697; WP:CE25818 cytochrome P450 C46F2.1 C46F2.1 C46F2.1; CE17557; WBGene00016714; WP:CE17557; XI695 C46H11.7 C46H11.7 C46H11.7; 1F610; CE08789; WBGene00016731; WP:CE08789 C46H11.9 C46H11.9 phat-2; C46H11.9; 1F614; CE08791; WBGene00016733; WP:CE08791 C47A4.2 C47A4.2 C47A4.2; 4O495; CE35435; CE35436; CE39699; WBGene00008123; WP:CE35435; WP:CE35436; WP:CE39699 C47A4.5 C47A4.5 C47A4.5; 4O511; CE19740; WBGene00008125; WP:CE19740 C47B2.5 C47B2.5 eif-6; C47B2.5; 1N561; CE17565; NM_060871; WBGene00001234; WP:CE17565 EUKARYOTIC TRANSLATION INITIATION FACTOR 6 (EIF-6) C47D2.2 C47D2.2 cdd-1; tag-17; C47D2.2; CE06962; NM_076983; WBGene00000391; WP:CE06962; XI826 cdd-1 encodes a cytidine deaminase that contains a zinc-binding region; expressed in the intestine. cytidine deaminase C47E12.7 C47E12.7 C47E12.7; 4K746; CE20571; WBGene00008151; WP:CE20571 Yeast YD78 like C47G2.1 C47G2.1 cut-1; vmp-1; C47G2.1; 2L561; CE02165; NM_064009; WBGene00000851; WP:CE02165 cut-1 encodes a component of cuticlin, an insoluble residue of the nematode cuticle required for alae formation and radial shrinking during dauer differentiation; expressed specifically in the cuticle of dauer larvae and is secreted by the seam cells. cuticulin C48B4.1 C48B4.1 C48B4.1; 3K676; CE00491; WBGene00008167; WP:CE00491 Acyl-CoA oxidase I C49C3.3 C49C3.3 C49C3.3; 4S260; WBGene00008193 C49C8.4 C49C8.4 cyp-33E1; C49C8.4; 4J410; CE31452; NM_069079; WBGene00016768; WP:CE31452 cytochrome P450 C49F5.1 C49F5.1 sams-1; C49F5.1; CE08852; WBGene00008205; WP:CE08852; XM585 s-adenosylmethionine synthetase C49F5.7 C49F5.7 C49F5.7; CE31455; WBGene00008211; WP:CE31455; XM615 C49G7.11 C49G7.11 djr-1.2; C49G7.11; 5E530; CE08869; WBGene00016789; WP:CE08869 C49G7.7 C49G7.7 C49G7.7; 5E511; CE08865; WBGene00016785; WP:CE08865 C49H3.11 C49H3.11 rps-2; C49H3.11; 4I690; CE04237; NM_068921; RS2_CAEEL; WBGene00004471; WP:CE04237 rps-2 encodes a small ribosomal subunit S2 protein. C50B6.4 C50B6.4 col-161; C50B6.4; 5N796; CE08873; NM_073899; WBGene00000734; WP:CE08873 collagen C50D2.1 C50D2.1 C50D2.1; 2A403; CE27874; WBGene00016805; WP:CE27874 C50F7.5 C50F7.5 C50F7.5; 4I491; CE04243; WBGene00016845; WP:CE04243 C50H11.15 C50H11.15 cyp-33C9; C50H11.15; 5D570; CE08931; NM_071445; WBGene00016860; WP:CE08931 cytochrome P450 C52D10.6 C52D10.6 skr-12; C52D10.6; 4S111; CE17590; NM_070644; WBGene00004818; WP:CE17590 skr-12 encodes a homolog of Skp1 in S. cerevisiae, a core component of the SCF (Skp1p, Cullin, F-box) ubiquitin-ligase complex that facilitates ubiquitin-mediated protein degradation; SKR-12 has no known function in vivo, since skr-12(RNAi) animals are at least superficially normal. cyclin A-associated protein C52D10.8 C52D10.8 skr-13; C52D10.8; 4S106; CE17592; NM_070641; WBGene00004819; WP:CE17592 The skr-13 gene encodes a homolog of Skp1 in S. cerevisiae that has no known function in vivo, since skr-13(RNAi) animals are at least superficially normal. cyclin A-associated protein C52E4.5 C52E4.5 C52E4.5; 5M464; CE08947; WBGene00008258; WP:CE08947 alpha 1,2, mannosidase C52E4.7 C52E4.7 C52E4.7; 5M475; CE08949; WBGene00008259; WP:CE08949 C53D5.6 C53D5.A, C53D5.I imb-3; C53D5.6; C53D5.A; 1A780; CE26971; NM_058314; Q9N5V3_CAEEL; WBGene00002077; WP:CE26971 imb-3 encodes an importin-beta-like protein orthologous to Drosophila, vertebrate, and yeast importin/karyopherin-beta3; IMB-3 is predicted to function as a nuclear transport factor that, with the RAN-1 GTPase, regulates nuclear import of ribosomal proteins; in C. elegans, IMB-3 is essential for embryogenesis and germline development, and may also be required for normal postembryonic growth rates. importin beta, nuclear transport factor C53D5.6 C53D5.A, C53D5.I imb-3; C53D5.6; C53D5.A; 1A780; CE26971; NM_058314; Q9N5V3_CAEEL; WBGene00002077; WP:CE26971 imb-3 encodes an importin-beta-like protein orthologous to Drosophila, vertebrate, and yeast importin/karyopherin-beta3; IMB-3 is predicted to function as a nuclear transport factor that, with the RAN-1 GTPase, regulates nuclear import of ribosomal proteins; in C. elegans, IMB-3 is essential for embryogenesis and germline development, and may also be required for normal postembryonic growth rates. importin beta, nuclear transport factor C53H9.2 C53H9.2 C53H9.2; 1C307; CE08963; CE33575; CE39907; WBGene00016907; WP:CE08963; WP:CE33575; WP:CE39907 C53H9.2 encodes at least three protein isoforms orthologous to the GTP-binding proteins human GNL1 (HSR1; OMIM:143024) and murine MMR1, as well as LSG1 in S. cerevisiae and many other eukaryotic and bacterial proteins; one alternative transcription unit of the C53H9.2 locus, C53H9.2a, has a natural nonsense transcript that is up-regulated in vivo by smg[-] mutations, indicating that C53H9.2 is a natural substrate for SMG-mediated nonsense suppresssion; C53H9.2 is required in mass RNAi assays for embryonic viability, normally rapid growth, and early embryonic nuclear positioning; since several other natural mRNA substrates of SMG suppression (e.g., rpl-3, rpl-8, rpl-10a, rpl-12) have protein products that are involved in translation, C53H9.2's protein products may function in translation as well, an inference supported by the observed role of LSG1 in cytoplasmic 60S ribosomal subunit biogenesis. C54A12.1 C54A12.1 ptr-6; C54A12.1; 2F534; CE39341; NM_062585; WBGene00004221; WBGene00016908; WP:CE39341 ptr-6 encodes an ortholog of Drosophila and human PTCHD3, which defines one of seven paralogous families of sterol sensing domain (SSD) proteins; PTR-6 is weakly required for normal molting from L4 to adult stages; however, PTR-6 in conjunction with PTR-1 and PTR-10 is strongly required for both molting and viability, with triple ptr-1/-6/-10 RNAi animals showing pronounced molting defects and lethality; PTR-6 is also required for normal growth to full size and locomotion. C54C6.1 C54C6.1 rpl-37; C54C6.1; 3E619; CE05493; NM_065326; WBGene00004451; WP:CE05493 rpl-37 encodes a large ribosomal subunit L37 protein. 60S ribosomal protein L37 C54C8.2 C54C8.2 C54C8.2; 1N33; CE08965; WBGene00008290; WP:CE08965 C54D10.7 C54D10.7 C54D10.7; 5M916; CE05503; WBGene00008301; WP:CE05503 C54D10.8 C54D10.8 C54D10.8; 5M922; CE35439; WBGene00008302; WP:CE35439 C54F6.4 C54F6.4 C54F6.4; 5I9; CE08976; WBGene00016922; WP:CE08976 F54A5.1 C54G6.4, F54A5.1 F54A5.1; F54A5.E; 1B465; CE20859; WBGene00018786; WP:CE20859 C55A1.6 C55A1.6 C55A1.6; 5Q121; CE08992; WBGene00008323; WP:CE08992 C55A6.3 C55A6.3 C55A6.3; 5L992; CE39483; WBGene00008332; WP:CE39483 dehydrogenase C55A6.5 C55A6.5 sdz-8; C55A6.5; 5L996; CE09002; WBGene00008334; WP:CE09002 alcohol dehydrogenase C55A6.6 C55A6.6 C55A6.6; 5L994; CE09003; WBGene00008335; WP:CE09003 alcohol dehydrogenase C55A6.7 C55A6.7 C55A6.7; 5M2; CE09004; WBGene00008336; WP:CE09004 alcohol dehydrogenase C55B7.1 C55B7.1 glh-2; C55B7.1; 1H93; CE09012; NM_059475; WBGene00001599; WP:CE09012 glh-2 encodes a putative DEAD-box RNA helicase that contains six CCHC zinc fingers and is homologous to Drosophila VASA, a germ-line-specific, ATP-dependent, RNA helicase; at non-permissive temperatures, GLH-2 plays a role in germ-line development and fertility, specifically in regulating the normal extent of germ-line proliferation, oogenesis, and the production of functional sperm; GLH-2 activity may also be required for the wild-type morphology of P granules and for localization of several protein components, but not accumulation of P granule mRNA components; GLH-2 interacts in vitro with itself and with KGB-1, a JNK-like MAP kinase; GLH-2 is a constitutive P granule component and thus, with the exception of mature sperm, is expressed in germ cells at all stages of development; GLH-2 is cytoplasmic in oocytes and the early embryo, while perinuclear in all later developmental stages as well as in the distal and medial regions of the hermaphrodite gonad; GLH-2 is expressed at barely detectable levels in males. RNA helicase C56A3.1 C56A3.1 grl-17; C56A3.1; 5O42; CE09029; NM_073958; WBGene00001726; WP:CE09029 grl-17 encodes a hedgehog-like protein, with an N-terminal signal sequence, a central proline-rich low-complexity region, and a C-terminal Ground-like (Grl) domain; GRL-17 is expressed in pharynx, rectal epithelium, amphid socket cells, larval arcade cells, and larval hypodermis; the Grl domain is predicted to form a cysteine-crosslinked protein involved in intercellular signalling, and it has subtle similarity to the N-terminal Hedge domain of HEDGEHOG proteins. C56A3.2 C56A3.2 C56A3.2; 5O10; CE09030; WBGene00008341; WP:CE09030 Transthyretin-like family C56A3.8 C56A3.8 C56A3.8; 5O41; CE40500; WBGene00008346; WP:CE40500 C56C10.8 C56C10.8 icd-1; C56C10.8; 2G878; BTF3_CAEEL; CE02573; NM_062935; WBGene00002045; WP:CE02573 Transcription factor BTF3 (human) C56E6.2 C56E6.2 C56E6.2; 2G815; CE30372; WBGene00016970; WP:CE30372 GTP-binding D1005.1 D1005.1 D1005.1; CE06997; WBGene00016995; WP:CE06997; XC101 ATP citrate lyase D1007.6 D1007.6 rps-10; D1007.6; 1F152; CE09041; NM_058997; O01869_CAEEL; WBGene00004479; WP:CE09041 rps-10 encodes a small ribosomal subunit S10 protein. 40S ribosomal protein S10 D1025.2 D1025.2 D1025.2; CE17610; WBGene00008354; WP:CE17610; XP132 D1044.2 D1044.2 D1044.2; 3G623; CE29243; CE29244; CE39713; WBGene00017028; WP:CE29243; WP:CE29244; WP:CE39713 C40H5.1 C40H5.1, D1053.5 nspa-9; C40H5.1; CE08649; WBGene00043187; WP:CE08649 D1086.3 D1086.3 D1086.3; 5O573; CE09061; WBGene00008390; WP:CE09061 D2023.1 D2023.1 D2023.1; 5M279; CE09071; WBGene00014300; WP:CE09071 D2023.7 D2023.7 col-158; D2023.7; 5M311; CE09077; NM_073580; WBGene00000731; WP:CE09077 collagen D2024.2 D2024.2 D2024.2; 4I9; CE04291; WBGene00017051; WP:CE04291 D2030.6 D2030.6 D2030.6; 1I162; CE09083; P90786_CAEEL; WBGene00008416; WP:CE09083 D2062.11 D2062.11 D2062.5 D2062.5 D2062.5; 2C911; CE09092; WBGene00017057; WP:CE09092 D2062.6 D2062.6 D2062.6; 2C909; CE09093; WBGene00017058; WP:CE09093 D2085.1 D2085.1 pyr-1; D2085.1; 2I947; CE03105; NM_063437; WBGene00004259; WP:CE03105 pyr-1 is orthologous to the human gene CARBAMYL PHOSPHATE SYNTHETASE I (CPS1, which when mutated leads to hyperammonemia (OMIM:237300); PYR-1 protein is predicted to be mitochondrial with 68% accuracy. glutamine-dependent carbamoyl-phosphate synthase, aspartate carbamoyltransferase, dihydroorotase D2089.5 D2089.5 gbh-1; D2089.5; 2K982; CE00940; NM_063904; WBGene00001522; WP:CE00940 gbh-1 encodes a predicted ortholog of human hBBOX1; expressed in the intestine and in head and body muscles. gamma-butyrobetaine,2-oxoglutarate dioxygenase D2092.8 D2092.8 D2092.8; 1H197; CE09107; WBGene00017068; WP:CE09107 D2096.8 D2096.8 D2096.8; 4J144; CE04306; WBGene00017075; WP:CE04306 E02A10.3 E02A10.3 E02A10.3; 5N67; CE27751; WBGene00008453; WP:CE27751 calmodulin-like protein E02H1.1 E02H1.1 E02H1.1; 2J880; CE30642; WBGene00008455; WP:CE30642 rRNA methyltransferase E02H1.6 E02H1.6 E02H1.6; 2J887; CE28286; WBGene00008458; WP:CE28286 E02H1.6 encodes an ortholog of human TAF9 (OMIM:600822; also known as AK6, adrenal gland protein AD-004 like protein, ADLP) and of S. cerevisiae Fap7p; like its human ortholog, E02H1.6 is nuclear, and is predicted to likewise be a TATA box binding protein (TBP)-associated factor mediating activation of RNA polymerase II; E02H1.6 prefers ATP and dATP as phosphate donors; E02H1.6's biochemical activity is unusual, since it also prefers AMP and dAMP as substrates, and tolerates CMP, TMP and shikimate acid as substrates as well; since yeast Fap7p promotes pre-rRNA cleavage, E02H1.6 may be multifunctional; in RNAi assays, E02H1.6 is required for normally fast growth. ATP binding protein E03H4.10 E03H4.10 clec-17; E03H4.10; 1N22; CE20647; WBGene00008477; WP:CE20647 C-type lectin domain E04A4.4 E04A4.4 hoe-1; E04A4.4; 4F504; CE29748; CE36588; WBGene00001983; WP:CE29748; WP:CE36588 hoe-1 is orthologous to human ELAC2 (OMIM:605367, associated with susceptibility to prostate cancer); hoe-1 is required for normally rapid growth and normally short body length in mass RNAi assays. E04A4.5 E04A4.5 E04A4.5; 4F508; CE16966; WBGene00017119; WP:CE16966 E04A4.8 E04A4.8, Y17G9B.E rpl-20; E04A4.8; 4F516; CE21392; NM_068229; WBGene00004432; WP:CE21392 rpl-20 encodes a large ribosomal subunit L18a protein. ribosomal protein E04D5.3 E04D5.3 cut-4; E04D5.3; 2K729; CE37892; WBGene00008482; WP:CE37892 cuticlin like protein E04F6.7 E04F6.7 dhs-7; E04F6.7; 2H496; CE01219; NM_063099; WBGene00000971; WP:CE01219 dhs-7 encodes a short-chain dehydrogenase predicted to be mitochondrial. Ribitol dehydrogenase E04F6.9 E04F6.9 E04F6.9; 2H502; CE01221; WBGene00017128; WP:CE01221 EEED8.2 EEED8.2 EEED8.2; 2F707; CE01886; WBGene00017133; WP:CE01886 EGAP2.3 EGAP2.3 pho-1; EGAP2.3; 2F524; CE04325; NM_062582; WBGene00004020; WP:CE04325 pho-1 encodes the major C. elegans intestinal acid phosphatase; as loss of PHO-1 function via RNA-mediated interference (RNAi) does not result in any abnormalities, PHO-1 may function redundantly with other acid phosphatases; PHO-1 intestinal expression appears to be positively regulated by CKI-1, a cyclin-dependent kinase inhibitor, and negatively regulated by POP-1, a TCF/LEF transcription factor; PHO-1 is expressed along the intestinal brush border in all gut cells except the most anterior int-1 and int-2 cells, beginning at the three-fold stage of embryogenesis. EGAP4.1 EGAP4.1 EGAP4.1; CE07012; WBGene00017149; WP:CE07012; XJ344 transposase F01D5.10 F01D5.10 F01D5.10; 2O306; CE18567; WBGene00008500; WP:CE18567 F01G10.4 F01G10.4 F01G10.4; 4K996; CE40607; WBGene00008507; WP:CE40607 F02A9.3 F02A9.3 far-2; pes-3; F02A9.3; 3K171; CE00134; FAR2_CAEEL; NM_066610; WBGene00001386; WP:CE00134 far-2 encodes a protein similar to a class of secreted fatty acid and retinol-binding proteins expressed in parasitic nematodes and secreted in the surrounding tissues of the host; expressed in body wall muscle and vulval cells of adult hermaphrodites, and transcript levels progressively increase during development. F07B10.1 F07B10.1 cln-3.1; F07B10.1; 5L744; CE09198; NM_073458; WBGene00000539; WP:CE09198 cln-3.1 encodes a predicted transmembrane protein that comprises one of three C. elegans homologs of human CLN3, (OMIM:607042, mutations are associated with Batten disease (also known as juvenile neuronal ceroid lipofuscinosis), a recessively inherited childhood neurodegenerative lysosomal storage disease); as loss of cln-3.1 activity via deletion mutation results in no obvious abnormalities, the precise role of cln-3.1 in C. elegans development and/or behavior is not yet known. Human CLN3 protein like F07C3.7 F07C3.7 aat-2; F07C3.7; 5J726; CE32853; NM_072993; WBGene00000003; WP:CE32853 aat-2 encodes a predicted amino acid transporter catalytic subunit; when co-expressed in Xenopus oocytes with a glycoprotein subunit, however, AAT-2 is not able to induce amino acid uptake. amino acid permease F07C4.6 F07C4.6 F07C4.6; 5I107; CE09205; WBGene00017200; WP:CE09205 F07C6.2 F07C6.2 F07C6.2; 4N555; CE05563; WBGene00008553; WP:CE05563 F07D10.1 F07D10.1 rpl-11.2; F07D10.1; CE07033; NM_076012; WBGene00004423; WP:CE07033; XC860 rpl-11.2 encodes a large ribosomal subunit L11 protein; by homology, RPL-11.2 is predicted to function in protein biosynthesis. ribosomal protein F07E5.5 F07E5.5 F07E5.5; 2C344; CE27916; WBGene00017210; WP:CE27916 zinc-finger protein F07F6.5 F07F6.5 F07F6.5; 2F726; CE01897; WBGene00017218; WP:CE01897 F07G11.1 F07G11.1 F07G11.1; 5H777; CE09222; WBGene00017228; WP:CE09222 F07G11.2 F07G11.2 F07G11.2; 5H775; CE09223; WBGene00017229; WP:CE09223 F07G11.3 F07G11.3 F07G11.3; 5H771; CE09224; WBGene00017230; WP:CE09224 F07G11.4 F07G11.4 F07G11.4; 5H764; CE09225; WBGene00017231; WP:CE09225 F07G11.5 F07G11.5 srj-32; F07G11.5; 5H766; CE38168; NM_072455; WBGene00005617; WP:CE38168 7TM chemoreceptor, srj family F07G6.6 F07G6.6 fbxa-52; F07G6.6; CE07039; WBGene00017225; WP:CE07039; XC324 F07G6.7 F07G6.7 fbxa-53; F07G6.7; CE39346; WBGene00017226; WP:CE39346; XC330 F08A8.2 F08A8.2 F08A8.2; 1N537; CE17634; WBGene00008565; WP:CE17634 ACYL-COENZYME A OXIDASE, PEROXISOMAL (EC 1.3.3.6) (PALMITOYL-COA OXIDASE) (AOX) F08A8.3 F08A8.3 F08A8.3; 1N541; CE17635; WBGene00008566; WP:CE17635 ACYL-COENZYME A OXIDASE, PEROXISOMAL (EC 1.3.3.6) (PALMITOYL-COA OXIDASE) (AOX) F08F1.8 F08F1.8 tth-1; F08F1.8; CE27929; NM_077029; WBGene00006649; WP:CE27929; XJ42 tth-1 encodes a thymosin beta ortholog that contains four functionally distinct thymosin beta repeats; in vitro, TTH-1 binds multiple actin monomers as well as filamentous actin suggesting that, as its homology predicts, TTH-1 plays a direct role in regulating actin polymerization and cytoskeletal organization in C. elegans; consistent with this, loss of tth-1 activity via a deletion mutation that removes upstream sequences results in animals with a dumpy morphology that are sterile as a result of maternal effect lethality associated with deformed oocytes containing abnormally distributed actin; tth-1 mRNA is present throughout development, while TTH-1 protein is detected in the adult gonad in the inside edges of the membranous structures surrounding germline nuclei, the cytoplasm and cortex of oocytes, early embryos at points of cell contact, the developing nerve ring, and then throughout the larval and adult body, with specific enrichment in the intestine and spermatheca. F08F3.4 F08F3.4 F08F3.4; 5F889; CE32856; WBGene00017262; WP:CE32856 F08F3.7 F08F3.7 ccp-14A5; cyp-14A5; F08F3.7; 5F900; CE09262; NM_072034; Q27531_CAEEL; WBGene00000373; WP:CE09262 ccp-14A5 encodes a member of the cytochrome P450 family. cytochrome P450 F08H9.3 F08H9.3 F08H9.3; 5O942; CE09267; WBGene00008591; WP:CE09267 F08H9.3 encodes a heat shock protein (HSP) of the HSP16 class; unlike most HSP16s in C. elegans, it is specifically expressed in a particular tissue (the larval pharynx and the anterior adult pharynx), and its expression is not strongly induced by heat shock; however, F08H9.3 expression is increased by heat shock (with adult expression in the full pharynx) and probably aids heat shock resistance, since F08H9.3(RNAi) animals have sensitivity to heat shock that is sporadically higher than normal; in general, HSP16 proteins are thought to act as passive ligands for unfolded proteins that keep them safe from aggregation until the proteins can be refolded by a large (ATP-consuming) HSP. heat shock protein F08H9.4 F08H9.4 F08H9.4; 5O946; CE09268; WBGene00008592; WP:CE09268 F08H9.4 encodes a heat shock protein (HSP) of the HSP16 class; unlike most HSP16s in C. elegans, it is specifically expressed in a particular tissue (the excretory canal and ventral nerve-cord neurons), and its expression is only mildly induced by heat shock; however, F08H9.4 expression is increased by heat shock, is induced in a new tissue type (intestine) by heat shock, and probably aids heat shock resistance, since F08H9.4(RNAi) animals die as embryos in heat shock at a higher rate than normal; in general, HSP16 proteins are thought to act as passive ligands for unfolded proteins that keep them safe from aggregation until the proteins can be refolded by a large (ATP-consuming) HSP. heat shock protein F08H9.5 F08H9.5 F08H9.5; 5O953; CE09269; WBGene00008593; WP:CE09269 C-type lectin domain F08H9.7 F08H9.7 clec-56; F08H9.7; 5O955; CE37968; WBGene00008595; WP:CE37968 C-type lectin domain F09A5.1 F09A5.1 F09A5.1; CE40809; WBGene00008598; WP:CE40809; XN747 tetracycline resistance like protein F09B9.1 F09B9.1 F09B9.1; CE15758; WBGene00008602; WP:CE15758; XK758 F09C3.1 F09C3.1 pes-7; tag-2; F09C3.1; 1O861; CE23636; NM_061091; WBGene00003980; WP:CE23636 pes-7 encodes an IQGAP ortholog; IQGAP proteins bind actin and CLIP-170, effect activities of the Rho family GTPases Rac1 and Cdc42, and function in cytokinesis; PES-7 is required for completing meiosis and mitosis, and for germline formation and maintenance; IQGAP's alpha-actinin domain is related distantly to alpha-actinin domains in calponin, transgelin (SM22 alpha), and the proto-oncogene Vav; a pes-7 reporter is first expressed in the ventral nerve cord of the elongating embryo and in later stages of development is also expressed in all major ganglia, the vulva, and in the spermathecal valves; in the ventral nerve cord, pes-7 expression is detected in nuclei as well as in cell bodies and neural processes. ras GTPase-activating protein like F09F7.3 F09F7.3 F09F7.3; 3G653; CE30653; WBGene00017300; WP:CE30653 F09F9.2 F09F9.2 F09F9.2; CE04347; WBGene00017307; WP:CE04347; XE728 F09G8.4 F09G8.4 ncr-2; npc-2; F09G8.4; 3J355; CE24891; NM_066412; WBGene00003562; WP:CE24891 ncr-2 encodes a homolog of human NPC1, which when mutated leads to Niemann-Pick disease, type C (OMIM:257220). F09G8.6 F09G8.6 col-91; F09G8.6; 3J348; CE00141; NM_066413; WBGene00000666; WP:CE00141 Cuticle collagen F10A3.2 F10A3.2 fbxa-88; F10A3.2; 5Q622; CE35458; O45335_CAEEL; WBGene00008632; WP:CE35458 This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins; this gene's encoded protein also contains an FTH/DUF38 motif, which may also mediate protein-protein interaction. F10A3.3 F10A3.3 fbxa-18; F10A3.3; 5Q623; CE15770; WBGene00008633; WP:CE15770 This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins. F10B5.1 F10B5.1 rpl-10; F10B5.1; 2I435; CE01543; NM_063306; WBGene00004421; WP:CE01543 rpl-10 encodes a large ribosomal subunit L10 protein required in mass RNAi assays for embryonic viability, fertility, normally rapid growth, and normal body coloration; the rpl-10 transcription unit has a nonsense transcript that is up-regulated in vivo by smg[-] mutations, indicating that rpl-10 is a natural substrate for SMG-mediated nonsense suppresssion; several other natural mRNA substrates of SMG suppression (e.g., rpl-3, rpl-7, rpl-12) have protein products that are involved in translation. ribosomal protein L10 (QM protein) F10C1.7 F10C1.7 ifb-2; F10C1.7; 2G41; CE02622; CE27941; CelIF b2; IF b2; IFB2_CAEEL; NM_062732; NM_062733; WBGene00002054; WP:CE02622; WP:CE27941 ifb-2 encodes a nonessential intermediate filament protein; IFB-2 is predicted to function as a structural component of the cytoskeleton; IFB-2 has no obvious function in RNAi assays. F10D11.6 F10D11.6 F10D11.6; 1J22; CE23640; WBGene00008652; WP:CE23640 F10E7.4 F10E7.4 spon-1; vab-13; ven-3; F10E7.4; 2H409; CE32368; WBGene00006893; WBGene00017346; WP:CE32368 F-spondin F10E7.5 F10E7.5 F10E7.5; 2H403; CE04360; WBGene00017347; WP:CE04360 F10E9.4 F10E9.4 F10E9.4; 3J399; CE00148; WBGene00017356; WP:CE00148 F10F2.3 F10F2.3 F10F2.3; 3F705; CE00948; WBGene00008655; WP:CE00948 lipase (Bacillus subtilis) F10G2.2 F10G2.2 F10G2.2; 5H809; CE09330; WBGene00017363; WP:CE09330 F10G7.1 F10G7.1 tag-151; F10G7.1; 2F3; CE02624; WBGene00006497; WP:CE02624 F11A1.3 F11A1.3 daf-12; mig-7; F11A1.3; CE27584; CE27585; CE27586; CE39240; WBGene00000908; WP:CE27584; WP:CE27585; WP:CE27586; WP:CE39240; XL285 daf-12 encodes a member of the steroid hormone receptor superfamily that affects dauer formation downstream of the TGF- and insulin signaling pathways, and affects gonad-dependent adult longevity together with DAF-16, chemosensory signal transduction, and distal tip cell migration and hypodermal and intestinal cell lineages during the L3 larval stage; expressed in the nucleus and in most cells; DAF-12 is homologous to human VITAMIN D RECEPTOR (VDR; OMIM:601769, mutated in vitamin D-resistant rickets. F11A3.1 F11A3.1 F11A3.1; 5J989; CE05585; WBGene00008669; WP:CE05585 4-coumarate-CoA ligase F11C1.6 F11C1.6 nhr-25; F11C1.6; CE03191; CE35856; NM_077761; WBGene00003623; WP:CE03191; WP:CE35856; XN631 nhr-25 encodes a nuclear hormone receptor orthologous to Drosophila Ftz-F1; NHR-25 is required for embryogenesis, molting, vulval and gonadal development, and hypodermal expression of acn-1; nhr-25 is expressed in gonads and loaded into embryos as a maternal transcript; nhr-25 is zygotically expressed in progeny of the E cell, and then in hypodermis and gut; the role of NHR-25 in molting may be evolutionarily conserved between nematodes and arthopods. F11C7.5 F11C7.5 F11C7.5; CE17657; WBGene00017377; WP:CE17657; XS34 F11E6.4 F11E6.4 F11E6.4; 4S412; CE31167; WBGene00008708; WP:CE31167 F11G11.1 F11G11.1 gst-8; F11G11.1; 2F175; CE07054; GST8_CAEEL; NM_062483; WBGene00001756; WP:CE07054 gst-8 encodes a predicted glutathione S-transferase. glutathione S-transferase F11G11.10 F11G11.10 col-17; F11G11.10; 2F156; CE31783; NM_062477; WBGene00000606; WP:CE31783 col-17 encodes a collagen which is expressed in all developmental stages except eggs, like col-15, col-16, and col-20; collagen genes with this expression pattern may be used for synthesis of cuticles after the L1 stage (e.g., the L4 cuticle). collagen F11G11.12 F11G11.12 col-73; F11G11.12; 2F162; CE09354; NM_062479; WBGene00000649; WP:CE09354 collagen F11G11.2 F11G11.2 gst-7; F11G11.2; 2F173; CE07055; GST7_CAEEL; NM_062482; WBGene00001755; WP:CE07055 gst-7 encodes a predicted glutathione S-transferase. glutathione S-transferase F13B10.2 F13B10.2 rpl-3; F13B10.2; 3E959; CE05598; CE36996; CE36997; NM_065382; RL3_CAEEL; WBGene00004414; WP:CE05598; WP:CE36996; WP:CE36997 rpl-3 encodes a large ribosomal subunit L3 protein required in mass RNAi assays for embryonic and larval viability, fertility, and general health; the rpl-3 transcription unit has a nonsense transcript that is up-regulated in vivo by smg[-] mutations, indicating that rpl-3 is a natural substrate for SMG-mediated nonsense suppresssion; several other natural mRNA substrates of SMG suppression (e.g., rpl-7, rpl-10, rpl-12) have protein products that are involved in translation. F13D12.4 F13D12.4 alh-8; F13D12.4; 2M21; CE02183; CE36262; MMSA_CAEEL; WBGene00000114; WP:CE02183; WP:CE36262 alh-8 is orthologous to the human gene METHYLMALONATE-SEMIALDEHYDE DEHYDROGENASE (ALDH6A1; OMIM:603178), which when mutated leads to MMSDH deficiency. F13G3.3 F13G3.3 F13G3.3; 1H874; CE27124; WBGene00008763; WP:CE27124 F13H6.1 F13H6.1 F13H6.1; 5G841; CE30755; WBGene00017430; WP:CE30755 zinc-finger protein F13H8.2 F13H8.2 F13H8.2; 2G563; CE27127; WBGene00017435; WP:CE27127 beta transducin Trp-Asp domains F13H8.7 F13H8.7 F13H8.7; 2G578; CE02641; WBGene00017440; WP:CE02641 beta-ureidopropionase (rat) F14D12.5 F14D12.5 sulp-2; F14D12.5; CE27963; NM_076543; WBGene00017464; WP:CE27963; XG216 sulp-2 encodes one of eight C. elegans members of the sulfate permease family of anion transporters; by homology, SULP-2 is predicted to function as an anion transporter that regulates cellular pH and volume via transmembrane movement of electrolytes and fluids and when expressed in Xenopus oocytes, SULP-2 does exhibit modest uptake of sulfate; a SULP-2::GFP fusion is expressed in the intestine and rectal gland cells, where it localizes to the basolateral membrane and in cephalic and deirid neurons, where it localizes to sensillar endings. sulfate transporter F14D7.6 F14D7.6 F14D7.6; 5O787; CE30658; WBGene00008793; WP:CE30658 Multidrug resistance protein like F14F3.3 F14F3.3 tag-289; F14F3.3; CE40384; WBGene00008806; WP:CE40384; XL142 F14F7.2 F14F7.2 cyp-13A11; F14F7.2; 3O111; CE15822; NM_067303; WBGene00008809; WP:CE15822 cytochrome P450 F15B9.1 F15B9.1 far-3; F15B9.1; 5N476; CE09406; NM_073850; WBGene00001387; WP:CE09406 O.volvulus antigen peptide like F15B9.2 F15B9.2 far-4; F15B9.2; 5N478; CE09407; NM_073851; WBGene00001388; WP:CE09407 far-4 encodes a fatty acid and retinol-binding protein, paralogous to FAR-3 and FAR-5 and distantly homologous to FAR proteins of parasitic nematodes; FAR-4 binds lipids in vitro; far-4 is transcribed at highest levels in the fourth larval stage, and is dispensable for viability and gross morphology in mass RNAi assays. O.volvulus antigen peptide like F15B9.6 F15B9.6 F15B9.6; 5N495; CE09411; WBGene00008850; WP:CE09411 phospholipase A2 F15D3.7 F15D3.7 F15D3.7; 1M171; CE15854; WBGene00008857; WP:CE15854 F15E11.7 F15E11.7 F15E11.8 F15E11.8 F15E11.9 F15E11.9 F15G9.4 F15G9.4 him-4; F15G9.4; CE18595; CE18596; CE40845; NM_077234; WBGene00001863; WP:CE18595; WP:CE18596; WP:CE40845; XK371 The him-4 gene encodes a large (5198-residue) extracellular protein, called 'hemicentin', that belongs to the immunoglobulin superfamily. IG (immunoglobulin) superfamily (47 domains) F15H10.1 F15H10.1 col-12; F15H10.1; 5K904; CE05638; NM_073277; WBGene00000601; WP:CE05638 col-12 encodes a member of the collagen superfamily containing collagen triple helix repeats (20 copies); expressed throughout development but expression peaks after each larval molt when new cuticle is being secreted and deposited, and after the L4 to adult larval molt. collagen F15H10.2 F15H10.2 col-13; F15H10.2; 5K902; CE05639; NM_073276; WBGene00000602; WP:CE05639 col-13 encodes a collagen which is expressed in all stages of development, like sqt-3 (col-1), col-3, col-10, col-11, col-12, and col-14; collagen genes with this expression profile may be specifically required to construct the L1 cuticle (and, perhaps, less specifically required for cuticles at other stages); the amino- and carboxyl-terminal cysteine-rich regions of COL-13 are most closely related to those of COL-6, COL-12, COL-14, COL-36, and COL-40. collagen F17A9.4 F17A9.4 F17A9.4; 5G590; CE09448; WBGene00017536; WP:CE09448 F17B5.1 F17B5.1 F17B5.1; 1N779; CE15865; WBGene00008905; WP:CE15865 F17C11.3 F17C11.3 col-153; F17C11.3; 5L431; CE05650; NM_073392; WBGene00000726; WP:CE05650 collagen F17E9.1 F17E9.1 col-116; F17E9.1; 4J123; CE07069; NM_069015; WBGene00000690; WP:CE07069 F17E9.11 F17E9.11 lys-10; F17E9.11; 4J95; CE07076; NM_069004; WBGene00003099; WP:CE07076 F17H10.2 F17H10.2 F17H10.2; CE03227; CE39242; WBGene00008926; WP:CE03227; WP:CE39242; XN731 F18C5.3 F18C5.3 tag-184; F18C5.3; 2G843; CE02652; WBGene00007050; WBGene00017558; WP:CE02652 F18E9.3 F18E9.3 F18E9.3; CE35494; WBGene00017569; WP:CE35494; XJ207 F19B2.2 F19B2.2 srz-34; F19B2.2; 5U640; NM_075488; WBGene00008942 F19F10.8 F19F10.8 F19F10.8; 5I50; CE36829; WBGene00017604; WP:CE36829 F19H8.4 F19H8.4 F19H8.4; 2O907; CE32632; WBGene00008964; WP:CE32632 F20B4.6 F20B4.6 cgt-2; F20B4.6; CE30960; WBGene00017625; WP:CE30960; XS315 F20B6.1 F20B6.1 F20B6.1; CE04423; WBGene00017627; WP:CE04423; XE819 protein tyrosine phosphatase F20B6.2 F20B6.2 vha-12; F20B6.2; CE04424; NM_076310; VATB_CAEEL; WBGene00006921; WP:CE04424; XE811 vha-12 encodes an ortholog of subunit B of the cytoplasmic (V1) domain of vacuolar proton-translocating ATPase (V-ATPase); VHA-12 is orthologous to human ATP6V1B1 (OMIM:192132, mutated in distal renal tubular acidosis with progressive sensorineural deafness) and ATP6V1B2 (OMIM:606939); VHA-12 and TAG-300/Y110A7A.12 are co-orthologs; VHA-17, like VHA-1 and VHA-12, antagonizes EFF-1-mediated cell fusion in hypodermal cells; VHA-12 is required for necrosis, since mutation of vha-12 suppresses necrotic neurodegeneration, cytoplasmic acidification, and thapsigargin-induced cell death; VHA-12 is predicted to bind ATP as part of a cytosolic VHA-12/VHA-13 heterohexamer, whose ATP hydrolysis drives the V-ATPase rotor; general levels of VHA-12 protein are very low in embryos but increase strongly after hatching. vacuolar ATP synthase (strong) F20D6.11 F20D6.11 F20D6.11; 5I678; CE27373; Q19655_CAEEL; WBGene00017640; WP:CE27373 oxidoreductase F20D6.2 F20D6.2 F20D6.2; 5I667; CE07107; WBGene00017634; WP:CE07107 F20E11.5 F20E11.5 F20E11.5; 5R938; CE18614; Q9XV81_CAEEL; WBGene00008983; WP:CE18614 F20E11.7 F20E11.7 F20E11.7; 5R943; CE18616; WBGene00008984; WP:CE18616 F20G2.1 F20G2.1 F20G2.1; 5O232; CE09504; WBGene00008985; WP:CE09504 dehydrogenase F21F8.3 F21F8.3 asp-5; F21F8.3; 5I753; CE09539; NM_072734; WBGene00000218; WP:CE09539 protease F21H12.5 F21H12.5 fbf-2; F21H12.5; 2G380; CE01916; NM_062819; WBGene00001402; WP:CE01916 fbf-2 encodes an RNA-binding protein that is one of 11 C. elegans members of the PUF family (Pumilio and FBF) of translational regulators; FBF-2 is nearly identical to FBF-1 with which it is largely redundant in regulating two aspects of germline development: 1)maintenance of stem cell proliferation, and 2)the hermaphroditic switch between spermatogenesis and oogenesis; in maintaining germline stem cells, the FBF proteins, acting through NOS-3, negatively regulate the activity of gld-1 mRNA, which encodes a translational repressor required for meiotic entry; in regulating the sperm-to-oocyte switch, the FBFs act downstream of GLD-3 to negatively regulate the activity of fem-3 mRNA, which encodes a novel protein required for germline sex determination; consistent with their role in germline development, FBF-1 and FBF-2 are expressed in the germline cytoplasm, becoming enriched in the mitotic region during the L4 larval and adult stages. F21H7.1 F21H7.1 gst-22; F21H7.1; 5Q712; CE15874; NM_074694; WBGene00001770; WP:CE15874 glutathione S-transferase F22B7.7 F22B7.7 twk-8; F22B7.7; 3J722; CE37508; NM_066502; WBGene00006662; WP:CE37508 Potassium channel protein F22B7.9 F22B7.9 F22B7.9; 3J742; CE29771; WBGene00017698; WP:CE29771 F22E10.1 F22E10.1 pgp-12; F22E10.1; CE03260; NM_077725; WBGene00004006; WP:CE03260; XN355 p-glycoprotein (MDR) F22E10.5 F22E10.5 F22E10.5; CE05695; WBGene00009057; WP:CE05695; XN383 phosphotransferase F22E5.1 F22E5.1 F22E5.1; 2C965; CE09553; WBGene00017703; WP:CE09553 F22E5.7 F22E5.7 F22E5.7; 2C933; CE27993; WBGene00017706; WP:CE27993 F22F4.1 F22F4.1 F22F4.1; CE07126; WBGene00017716; WP:CE07126; XG625 F23A7.4 F23A7.4 F23A7.4; CE09578; WBGene00009069; WP:CE09578; XQ825 glutamate receptor epsilon subunit like F23B12.4 F23B12.4 F23B12.4; CE09596; WBGene00009081; WP:CE09596 F23B2.10 F23B2.10 F23B2.10; 4J918; CE09590; WBGene00009077; WP:CE09590 F23B2.11 F23B2.11 pcp-3; F23B2.11; 4J920; CE40648; NM_069197; WBGene00003958; WP:CE40648 lysosomal carboxypeptidase F23B2.12 F23B2.12 pcp-2; F23B2.12; 4J926; CE09592; NM_069198; WBGene00003957; WP:CE09592 lysosomal carboxypeptidase F23F1.2 F23F1.2 F23F1.2; 2A325; CE09602; WBGene00017743; WP:CE09602 F25B5.3 F25B5.3 F25B5.3; 3H41; CE26890; CE28001; CE29776; CE30663; CE30664; WBGene00017775; WP:CE26890; WP:CE28001; WP:CE29776; WP:CE30663; WP:CE30664 F25B5.3 is orthologous to the human gene NUCLEOTIDASE, 5-PRIME, CYTOSOLIC III (NT5C3; OMIM:606224), which when mutated leads to hemolytic anemia due to UMPH1 deficiency F25H8.2 F25H8.2 F25H8.2; 4K697; CE05728; WBGene00009132; WP:CE05728 F25H8.6 F25H8.6 zbed-6; F25H8.6; 4K689; CE05731; WBGene00009133; WP:CE05731 F26A1.9 F26A1.9 F26A1.9; 3F910; CE29287; WBGene00017807; WP:CE29287 F26C11.1 F26C11.1 F26C11.1; 2K187; CE05732; WBGene00009146; WP:CE05732 acid phosphatase F26D11.2 F26D11.2 F26D11.2; 5I435; CE17706; WBGene00017819; WP:CE17706 F26D11.4 F26D11.4 F26D11.4; 5I424; CE17708; WBGene00017821; WP:CE17708 F26F4.7 F26F4.7 nhl-2; F26F4.7; 3F984; CE29291; NM_065625; WBGene00003598; WP:CE29291 F26G1.4 F26G1.4 ttm-2; F26G1.4; 2F54; CE02696; NM_062454; WBGene00017840; WP:CE02696 F26G1.5 F26G1.5 F26G1.5; 2F60; CE02697; WBGene00017841; WP:CE02697 F27C1.8 F27C1.8 dpy-5; F27C1.8; 1G0; CE09720; NM_059194; WBGene00001067; WP:CE09720 dpy-5 encodes a Group I cuticle procollagen; dpy-5 activity is required for wild-type body length, cuticle structure (width of the annuli), postembryonic growth rates, and reproduction; dpy-5 is described as an intermediate collagen gene, as its mRNA, which is present in all larval stages, adults, and dauer larvae, increases in abudance two hours prior to the secretion of each new cuticle; a dpy-5::gfp fusion gene is expressed in hypodermal cells from mid-to-late L1 larval stages to adulthood, with notably variable expression in the V lineage-derived seam cells; dpy-5 mutations suppress mutations in bli-4, which encodes a proprotein convertase that may process DPY-5 for normal cuticle production; in addition, dpy-5 is required for normal expression patterns of the COL-19, DPY-7, and DPY-13 cuticle collagens. cuticular collagen F27C8.4 F27C8.4 spp-18; F27C8.4; 4K359; CE03269; NM_069303; WBGene00005003; WP:CE03269 F27E11.1 F27E11.1 F27E11.1; 5D943; CE09732; WBGene00017867; WP:CE09732 nucleoside transporter F28A10.6 F28A10.6 F28A10.6; 2B138; CE19411; WBGene00017874; WP:CE19411 acyl-coA dehydrogenase F28C6.7 F28C6.7A rpl-26; F28C6.7; 2I893; CE03278; CE20731; CE32883; NM_063422; NM_063423; NM_182165; WBGene00004440; WP:CE03278; WP:CE20731; WP:CE32883 rpl-26 encodes a large ribosomal subunit L26 protein; by homology, RPL-26 is predicted to function in protein biosynthesis; in C. elegans, RPL-26 activity is required for embryonic and germline development and normal rates of postembryonic growth. F28D1.4 F28D1.4 thn-3; F28D1.4; 4N145; CE05744; NM_069960; WBGene00009214; WP:CE05744 Arabidopsis pathogenesis-related protein 5 like F28D1.5 F28D1.5 thn-2; F28D1.5; 4N149; CE05745; NM_069961; WBGene00009215; WP:CE05745 Arabidopsis pathogenesis-related protein 5 like F28F5.3 F28F5.3 lim-8; tag-204; F28F5.3; 3H905; CE29296; CE29297; CE30771; Q8MNT0_CAEEL; WBGene00017904; WP:CE29296; WP:CE29297; WP:CE30771 F28G4.1 F28G4.1 cyp-37B1; F28G4.1; 5Q759; CE15919; NM_074708; WBGene00009226; WP:CE15919 cytochrome P450 F28H6.1 F28H6.1 akt-2; F28H6.1; AKT2_CAEEL; CE18646; CE29298; NM_077956; WBGene00000103; WP:CE18646; WP:CE29298; XO769 akt-2 encodes a homolog of the serine/threonine kinase Akt/PKB, AKT-2, that is required for progression through the dauer stage of development and for the negative regulation of adult lifespan; inactivation of akt-2 causes animals to arrest constitutively at the dauer stage, while having an increased life span; widely expressed, AKT-2 is activated by the phospholipid products of phosphoinositide 3-kinase AGE-1/PI3K and by PDK-1, a homolog of vertebrate 3-phosphoinositide-dependent kinase-1 (PDK-1) Normal akt-2 (and akt-1) activity is required for excess pdk-1 activity to suppress the dauer-arrest phenotype of age-1, indicating that the 3-phosphoinositide-dependent kinase-1 homolog PDK-1 transduces signals from AGE-1 to AKT-2 (and AKT-1); conversely, the akt-2 loss-of-function phenotype is suppressed by daf-16 null mutations, indicating that the Fork head transcription factor DAF-16 is downstream of AKT-2 (and AKT-1), and that AKT-1 and AKT-2 act primarily to antagonize DAF-16. PH (pleckstrin homology) domain, Protein kinase C terminal domain F29C12.4 F29C12.4 F29C12.4; 2N411; CE19822; WBGene00009246; WP:CE19822 Elongation factor Tu family (contains ATP/GTP binding P-loop), Elongation factor G C-terminus F29G6.3 F29G6.3 F29G6.3; CE18655; CE36483; CE36484; Q93637_CAEEL; WBGene00009259; WP:CE18655; WP:CE36483; WP:CE36484; XM130 F30B5.1 F30B5.1 dpy-13; dpy-16; F30B5.1; 4F1; CE04462; NM_068118; WBGene00001074; WP:CE04462 dpy-13 encodes a member of the collagen superfamily containing 20 copies of the collagen triple helix repeat; transcipt levels oscillate, peaking once during each larval stage. cuticular collagen F31F4.15 F31F4.15 fbxa-72; F31F4.15; 5B150; CE09835; WBGene00017962; WP:CE09835 F32A11.6 F32A11.6 moe-3; F32A11.6; 2N452; CE18657; NM_064394; Q9XV46_CAEEL; WBGene00003388; WP:CE18657 Zinc finger C-x8-C-x5-C-x3-H type (and similar). F32D1.5 F32D1.5 F32D1.5; 5E848; CE09869; WBGene00017984; WP:CE09869 GMP reductase F32D8.8 F32D8.8 F32D8.8; 5L380; CE05787; WBGene00009332; WP:CE05787 F32G8.2 F32G8.2 F32G8.2; 5L33; CE05791; WBGene00009338; WP:CE05791 F32G8.3 F32G8.3 F32G8.3; 5L34; CE05792; WBGene00009339; WP:CE05792 F33D11.1 F33D11.1 F33D11.1; 1G427; CE09891; WBGene00018000; WP:CE09891 LIM protein F33D11.3 F33D11.3 col-54; F33D11.3; 1G421; CE09893; NM_059293; WBGene00000631; WP:CE09893 collagen F33H2.8 F33H2.8 F33H2.8; 1P622; CE37514; WBGene00009371; WP:CE37514 F34D10.4 F34D10.4 F34D10.4; 3E829; CE17770; WBGene00009374; WP:CE17770 F34D6.4 F34D6.4 set-11; F34D6.4; 2C980; CE36838; WBGene00018023; WP:CE36838 F35B3.4 F35B3.4 F35B3.4; CE07171; WBGene00018031; WP:CE07171; XR632 F35E12.8 F35E12.8 F35E12.8; 5O230; CE32403; WBGene00009432; WP:CE32403 F35E12.9 F35E12.9 F35E12.9; 5O222; CE32404; CE38514; WBGene00009433; WP:CE32404; WP:CE38514 F35G2.4 F35G2.4 phy-2; F35G2.4; 4M976; CE05811; NM_069916; WBGene00004025; WP:CE05811 prolyl 4-hydroxylase alpha subunit F35H10.3 F35H10.3 F35H10.3; 4J89; CE36592; WBGene00018069; WP:CE36592 F36G3.2 F36G3.2 F36G3.2; CE01577; WBGene00009483; WP:CE01577; XK412; YQY2_CAEEL F36G9.7 F36G9.7 F36G9.7; 5Q446; CE15984; WBGene00009486; WP:CE15984 F37B1.5 F37B1.5 gst-16; F37B1.5; 2N914; CE09992; NM_064462; WBGene00001764; WP:CE09992 glutathione S-transferase F37B4.2 F37B4.2 ifc-1; F37B4.2; 5D361; CE27378; Cel IF C1; CelIF c1; NM_071382; WBGene00002055; WP:CE27378 ifc-1 encodes a nonessential intermediate filament protein; IFC-1 is predicted to function as a structural component of the cytoskeleton; IFC-1 has no function in RNAi assays. intermediate filament protein F37C12.11 F37C12.11 rps-21; F37C12.11; 3I278; CE30779; NM_066178; RS21_CAEEL; WBGene00004490; WP:CE30779 rps-21 encodes a small ribosomal subunit S21 protein; by homology, RPS-21 is predicted to function in protein biosynthesis; in C. elegans, RPS-21 activity is required for embryonic and germline development, as well as the overall health of the animal. Ribosomal protein S21 F37C12.4 F37C12.4 rpl-36; F37C12.4; 3I271; CE30781; NM_066172; RL36_CAEEL; WBGene00004450; WP:CE30781 rpl-36 encodes a large ribosomal subunit L36 protein; by homology, RPL-36 is predicted to function in protein biosynthesis; in C. elegans, RPL-36 activity is required for embryonic and germline development and normal postembryonic growth rates. Ribosomal protein YL39 F37C4.3 F37C4.3 F37C4.3; 4E649; CE17046; WBGene00018143; WP:CE17046 F37H8.3 F37H8.3 F37H8.3; 2L473; CE35870; WBGene00009512; WP:CE35870 haloacid dehalogenase-like hydrolase F38A3.2 F38A3.2 col-82; ram-2; ram-3; F38A3.2; 2L306; CE02214; NM_063961; WBGene00004300; WP:CE02214 ram-2 encodes a cuticle collagen that interacts with unc-6 to affect ray cell migration, and interacts with unc-5 and unc-6 to affect embryonic viability; also affects ray morphology in males such that the structural cells and the hypodermis of the rays are swollen in mutants. collagen F38A5.13 F38A5.13 dnj-11; F38A5.13; 4H351; CE10050; NM_068605; WBGene00001029; WP:CE10050 This gene encodes a protein containing a DnaJ ('J') domain. DNA-binding protein F38E11.1 F38E11.1 hsp-12.3; F38E11.1; 4K208; CE03293; NM_069266; WBGene00002012; WP:CE03293 alpha-B-crystallin F38H4.8 F38H4.8 ech-2; F38H4.8; 4M616; CE17808; NM_069845; WBGene00001151; WP:CE17808 enoyl-CoA hydratase F39B2.6 F39B2.6 rps-26; F39B2.6; 1P353; CE16012; NM_061170; WBGene00004495; WP:CE16012 rps-26 encodes a small ribosomal subunit S26 protein; by homology, RPS-26 is predicted to function in protein biosynthesis; in C. elegans, RPS-26 activity is required for embryonic, larval, and germline development, as well as normal locomotion and body morphology. 40S ribosomal protein S26 F39E9.1 F39E9.1 F39E9.1; 2D607; CE38599; WBGene00018194; WP:CE38599 F39G3.6 F39G3.6 F39G3.6; 5F189; CE32186; WBGene00018211; WP:CE32186 F40F11.1 F40F11.1 rps-11; F40F11.1; 4M367; CE05860; NM_069785; WBGene00004480; WP:CE05860 rps-11 encodes a small ribosomal subunit S11 protein; by homology, RPS-11 is predicted to function in protein biosynthesis; in C. elegans, RPS-11 activity is required for embryonic and germline development, as well as the overall health of the animal. ribosomal protein S11 F40F8.10 F40F8.10 rps-9; F40F8.10; 2L416; CE05849; NM_063983; WBGene00004478; WP:CE05849 rps-9 encodes a small ribosomal subunit S9 protein. ribosomal protein S9 F40F9.9 F40F9.9 AQP-CE2; aqp-4; F40F9.9; 5K225; CE31345; WBGene00000172; WP:CE31345 MIP transmembrane protein F40G12.5 F40G12.5 F40G12.5; 5O750; CE10184; WBGene00009600; WP:CE10184 F40G9.5 F40G9.5 F40G9.5; 3A799; CE19852; WBGene00018241; WP:CE19852 F41B5.2 F41B5.2 cyp-33C7; F41B5.2; 5C729; CE10218; NM_071217; WBGene00018260; WP:CE10218 cytochrome P450 F41C3.11 F41C3.11 F41C3.11; 2F24; CE37372; WBGene00018275; WP:CE37372 F41C3.5 F41C3.5 F41C3.5; 2F29; CE02733; WBGene00018271; WP:CE02733 Serine carboxypeptidase F41C3.7 F41C3.7 F41C3.7; 2F25; CE39935; WBGene00018273; WP:CE39935 F41C6.5 F41C6.5 col-173; F41C6.5; CE04542; NM_076761; WBGene00000746; WP:CE04542; XH494 cuticular collagen F41E7.4 F41E7.4 fip-5; F41E7.4; CE03304; WBGene00009620; WP:CE03304; XK921 F41F3.3 F41F3.3 F41F3.3; 5F126; CE07217; WBGene00018297; WP:CE07217 cuticlin F42A6.8 F42A6.8 fbxa-130; F42A6.8; 4E104; CE17060; WBGene00018329; WP:CE17060 F42A9.5 F42A9.5 cyp-33E2; F42A9.5; 4J373; CE07227; NM_069069; WBGene00018334; WP:CE07227 cytochrome P450 F42C5.10 F42C5.10 F42C5.10; 4I86; CE28393; Q20330_CAEEL; WBGene00018350; WP:CE28393 F42C5.3 F42C5.3 F42C5.3; 4I44; CE04556; WBGene00018345; WP:CE04556 F42C5.7 F42C5.7 grl-4; F42C5.7; 4I74; CE34016; NM_068765; WBGene00001713; WP:CE34016 grl-4 encodes a hedgehog-like protein, with an N-terminal signal sequence, a central proline-rich low-complexity region, and a C-terminal Ground-like (Grl) domain; GRL-4 is expressed in pharynx, reproductive system, vulva, larval neurons, and larval rectal epithelium; the Grl domain is predicted to form a cysteine-crosslinked protein involved in intercellular signalling, and it has subtle similarity to the N-terminal Hedge domain of HEDGEHOG proteins. F42C5.8 F42C5.8 rps-8; F42C5.8; 4I78; CE04561; NM_068766; WBGene00004477; WP:CE04561 rps-8 encodes a small ribosomal subunit S8 protein; by homology, RPS-8 is predicted to function in protein biosynthesis; in C. elegans, RPS-8 activity is required for germline development and the overall health of the animal. 40S ribosomal protein S8 F42E11.4 F42E11.4 tni-1; F42E11.4; CE03311; NM_077505; TNNI1_CAEEL; WBGene00006584; WP:CE03311; XL994 tni-1 encodes a member of the troponin family that affects body morphology, locomotion, egg laying, and epithelial morphogenesis in a large-scale RNAi analysis. troponin I F42F12.3 F42F12.3 F42F12.3; CE03314; Q20344_CAEEL; WBGene00009635; WP:CE03314; XM969 3-oxo-5-alpha-steroid 4-dehydrogenase F42H10.5 F42H10.5 F42H10.5; 3J569; CE00167; WBGene00018369; WP:CE00167 F43E2.5 F43E2.5 F43E2.5; 2H652; CE07241; WBGene00018393; WP:CE07241 F43E2.5 encodes a methionine sulfoxide-S-reductase (MsrA) with experimentally confirmed activity. F43H9.2 F43H9.2 sptl-2; F43H9.2; 5I501; CE07246; CE27380; WBGene00018398; WP:CE07246; WP:CE27380 serine palmtoyltransferase F43H9.4 F43H9.4 F43H9.4; 5I507; CE27381; WBGene00018400; WP:CE27381 F44A2.7 F44A2.7 F44A2.7; 5J799; CE35308; Q20382_CAEEL; WBGene00018406; WP:CE35308 F44C4.5 F44C4.5 ppt-1; F44C4.5; 5H104; CE07253; NM_072283; WBGene00004092; WP:CE07253 ppt-1 encodes the C. elegans palmitoyl protein thioesterase-1 ortholog; by homology PPT-1 is predicted to function in degradation of palmitoylated proteins and ppt-1 mutations result in loss of enzymatic activity from mixed-stage extracts; in C. elegans, ppt-1 activity is essential for mitochondrial organization and biogenesis in neuronal and muscle cells, as well as for proper timing of the onset of both the L4-to-adult molt and egg laying; ppt-1 is also required for normal egg-laying behavior and for a fully normal adult palmitoyl-protein thioesterase precursor F44C8.7 F44C8.7 F44C8.7; 5C695; CE30797; O16356_CAEEL; WBGene00018414; WP:CE30797 F44G3.10 F44G3.10 F44G3.10; 5Q618; CE16041; WBGene00009710; WP:CE16041 F44G3.10 encodes a claudin homolog that may be required for normal cohesion of apical junctions in epithelia; F44G3.10 is worm-specific, with obvious homologs only in C. elegans; F44G3.10 has no obvious function in mass RNAi assays; claudins are integral membrane proteins with four transmembrane sequences that are found in mammalian tight junctions (TJs), induce TJs when transgenically expressed in cells normally lacking them, and can mediate the specific conductance of of specific ions (e.g., magnesium or calcium) through TJs while blocking the flow of water. F44G3.12 F44G3.8 fbxa-142; F44G3.12; CE39253; WBGene00044659; WP:CE39253 F45D11.D F45D11.D F45D11.O F45D11.O F45D11.P F45D11.P F45D11.Q F45D11.Q F45D11.R F45D11.R F45D11.1 F45D11.S F45D11.1; 2B313; CE32665; WBGene00018448; WP:CE32665 F45D3.2 F45D3.2 F45D3.2; 5N21; CE38517; WBGene00009722; WP:CE38517 F45E4.5 F45E4.5 F45E4.5; 4I392; CE35313; WBGene00018470; WP:CE35313 F45E4.9 F45E4.9 hmg-5; F45E4.9; 4I410; CE10508; NM_068844; WBGene00001975; WP:CE10508 F45F2.1 F45F2.1 F45F2.1; 5J19; CE10518; WBGene00018477; WP:CE10518 F46B3.5 F46B3.5 grd-2; F46B3.5; 5V83; CE34022; NM_075576; WBGene00001691; WP:CE34022 grd-2 encodes a hedgehog-like protein, with (from N- to C-terminus) a signal sequence, four Ground domains, an short region of low-complexity sequence, and a Hint/Hog domain; the Hint/Hog domain is predicted to cut GRD-2 into two halves and then covalently link cholesterol to the C-terminus of the Ground domain; the four N-terminal Ground domains are predicted to form one or more cysteine-crosslinked proteins involved in intercellular signalling; Ground domains have subtle similarity to the N-terminal Hedge domain of HEDGEHOG proteins; GRD-2 is weakly required for normal molting; GRD-2 is also required for normal adult alae formation, growth to full size, locomotion, and male tail development; all of these requirements may reflect common defects in cholesterol-dependent hedgehog-like signalling or in vesicle trafficking. F46B6.7 F46B6.7 ztf-7; F46B6.7; 5K268; CE05873; WBGene00009772; WP:CE05873 Zinc finger, C2H2 type F46B6.8 F46B6.8 F46B6.8; 5K273; CE05874; WBGene00009773; WP:CE05874 lipase F46C5.1 F46C5.1 F46C5.1; 2J110; CE03343; WBGene00009778; WP:CE03343 F46F11.2 F46F11.2 cey-2; F46F11.2; 1G189; CE10598; NM_059244; P91306_CAEEL; WBGene00000473; WP:CE10598 cey-2 encodes a cold-shock/Y-box domain-containing protein; by homology, CEY-2 is predicted to function as either an RNA-binding protein involved in translation or RNA processing, or a DNA-binding protein involved in transcriptional regulation; cey-2 mRNA is expressed maternally in the early embryo, in a pattern characteristic of class II maternal RNAs, which are initially detected throughout the embryo but restricted to the P, or germline, lineage as cell division progresses; as loss of cey-2 activity via large-scale RNAi screens does not result in any obvious abnormalities, the precise role of cey-2 in C. elegans development and/or behavior is not yet known. F46F5.15 F46F5.15 F46F5.15; 2B81; CE19431; WBGene00018506; WP:CE19431 F46G10.4 F46G10.4 F46G10.4; CE02240; WBGene00009798; WP:CE02240; XN953 lipase F46H5.6 F46H5.6 grd-7; F46H5.6; CE37648; NM_076823; WBGene00001696; WP:CE37648; XH886 grd-7 encodes a hedgehog-like protein, with an N-terminal DUF271 domain, a central low-complexity proline-rich domain, and a C-terminal Ground (Grd) domain; GRD-7 is expressed in three to four posterior DA motor neurons of the ventral nerve cord; the Ground domain is predicted to form a cysteine-crosslinked protein involved in intercellular signalling, and it has subtle similarity to the N-terminal Hedge domain of HEDGEHOG proteins; GRD-7 is weakly required for normal molting; GRD-7 is also required for normal growth to full size, cuticle adhesion, locomotion, and vulval morphogenesis; all of these requirements may reflect common defects in cholesterol-dependent hedgehog-like signalling or in vesicle trafficking. F47B10.2 F47B10.2 F47B10.2; CE03352; HUTH_CAEEL; WBGene00009813; WP:CE03352; XL512 F47B10.2 is orthologous to the human gene HISTIDASE (HAL; OMIM:235800), which when mutated leads to disease. histidine ammonia-lyase F47B10.8 F47B10.8 F47B10.8; CE32424; WBGene00009819; WP:CE32424; XL524 F47B10.9 F47B10.9 F47B10.9; CE03359; WBGene00009820; WP:CE03359; XL530 F47B8.1 F47B8.1 F47B8.1; 5O794; CE10632; WBGene00009802; WP:CE10632 F47B8.3 F47B8.3 F47B8.3; 5O800; CE10636; WBGene00009804; WP:CE10636 F47B8.4 F47B8.4 F47B8.4; 5O804; CE10638; WBGene00009805; WP:CE10638 F47C10.2 F47C10.2 F47C10.2; 5E326; CE10658; WBGene00018540; WP:CE10658 F47C12.1 F47C12.1 F47C12.1; 4E763; CE10670; WBGene00018546; WP:CE10670 F47C12.2 F47C12.2 clec-78; F47C12.2; 4E751; CE10672; WBGene00018547; WP:CE10672 F47F6.3 F47F6.3 F47F6.3; 2B552; CE39154; WBGene00018573; WP:CE39154 F47G4.3 F47G4.3 gpdh-1; F47G4.3; 1O669; CE18701; WBGene00009824; WP:CE18701 gpdh-1 encodes one of two C. elegans glycerol 3-phosphate dehydrogenases; although loss of gpdh-1 activity via large-scale RNAi screens results in no obvious defects, gpdh-1 mRNA expression is upregulated in response to hypertonicity, suggesting that GPDH-1 does play a role in osmotic stress adaptation in C. elegans. NAD-dependent glycerol-3-phosphate dehydrogenase F47H4.10 F47H4.10 skr-5; F47H4.10; 5R829; CE20827; NM_074992; WBGene00004811; WP:CE20827 The skr-5 gene encodes a homolog of Skp1 in S. cerevisiae that has no known function in vivo, since skr-5(RNAi) animals are at least superficially normal. F47H4.4 F47H4.4 fbxa-185; F47H4.4; 5R813; CE19876; WBGene00009836; WP:CE19876 F48C1.1 F48C1.1 aman-3; F48C1.1; 1F897; CE36934; WBGene00018594; WP:CE36934 alpha-mannosidase II F48D6.4 F48D6.4 F48D6.4; CE07261; CE28400; CE29328; WBGene00018602; WP:CE07261; WP:CE28400; WP:CE29328; XE866 F48F7.3 F48F7.3 F48F7.3; CE05890; WBGene00009849; WP:CE05890; XO585 F48G7.2 F48G7.2 F48G7.2; 5B117; CE33099; WBGene00018614; WP:CE33099 F48G7.4 F48G7.4 F48G7.4; 5B97; CE10760; WBGene00018615; WP:CE10760 F49C12.7 F49C12.7 F49C12.7; 4K74; CE03367; CE39936; CE39937; WBGene00009877; WP:CE03367; WP:CE39936; WP:CE39937 F49E11.9 F49E11.9 scl-1; F49E11.9; 4N819; CE05905; NM_070101; WBGene00004742; WP:CE05905 testis-specific protein TPX-1 like F49E2.2 F49E2.2, F49E2.3 F49E2.2; CE31527; CE31528; Q20621_CAEEL; WBGene00009886; WP:CE31527; WP:CE31528; XK191 F49E2.2 F49E2.2, F49E2.3 F49E2.2; CE31527; CE31528; Q20621_CAEEL; WBGene00009886; WP:CE31527; WP:CE31528; XK191 F49F1.10 F49F1.10 F49F1.10; 4E900; CE17093; WBGene00018650; WP:CE17093 F49H12.5 F49H12.E F49H12.5; CE20835; WBGene00018656; WP:CE20835; XC693 F52B11.5 F52B11.5 F52B11.5; 4O866; CE18725; WBGene00009927; WP:CE18725 F52C6.13 F52C6.13 F52C6.13; 2C222; CE17099; WBGene00018670; WP:CE17099 F52E1.3 F52E1.3 F52E1.3; 5I873; CE04631; WBGene00018693; WP:CE04631 F52F10.2 F52F10.2 F52F10.2; 5C27; CE29388; WBGene00018706; WP:CE29388 F52H3.5 F52H3.5 F52H3.5; 2K321; CE03401; WBGene00009947; WP:CE03401 F52H3.7 F52H3.7 lec-2; F52H3.7; 2K300; CE29330; CE32894; NM_063764; Q20684_CAEEL; WBGene00002265; WP:CE29330; WP:CE32894 lec-2 encodes a 'tandem repeat' type galectin (beta-galactosyl-binding lectin) containing two, tandemly arranged carbohydrate recognition domains; by homology, LEC-2 may play roles in cell adhesion and aggregation, proliferation, or programmed cell death, but as loss of lec-2 activity via large-scale RNAi screens does not result in obvious abnormalities, the precise role of LEC-2 in C. elegans development and/or behavior is not yet known. galactoside-binding lectin F53A3.3 F53A3.3 rps-22; F53A3.3; 3D39; CE10884; NM_065080; O17218_CAEEL; WBGene00004491; WP:CE10884 rps-22 encodes a small ribosomal subunit S15a protein. 40S ribosomal protein F53A9.8 F53A9.8 F53A9.8; CE02768; WBGene00018731; WP:CE02768; XJ336 F53B6.1 F53B6.1 tsp-15; F53B6.1; 1J503; CE26464; NM_060003; WBGene00006641; WP:CE26464 tetraspanin F53C11.1 F53C11.1 F53C11.1; 5O257; CE32431; WBGene00009971; WP:CE32431 F53E10.6 F53E10.6 F53E10.6; 5D80; CE10930; WBGene00018762; WP:CE10930 F53F1.4 F53F1.4 F53F1.4; 5N891; CE10938; WBGene00009982; WP:CE10938 cuticlin F53F1.5 F53F1.5 F53F1.5; 5N893; CE10940; NM_073924; WBGene00009983; WP:CE10940 cuticlin F53F4.11 F53F4.11 F53F4.11; 5O104; CE20849; WBGene00009993; WP:CE20849 F53F4.4 F53F4.4 F53F4.4; 5O77; CE10960; WBGene00009988; WP:CE10960 F53F4.5 F53F4.5 fmo-14; fmo-4; F53F4.5; 5O84; CE30676; NM_073969; WBGene00001479; WP:CE30676 fmo-14 encodes a protein with homology to human hepatic flavin-containing monooxygenase 5. flavin-containing monoxygenase F53G12.10 F53G12.10 rpl-7; F53G12.10; 1A583; CE11024; NM_058275; RL7_CAEEL; WBGene00004418; WP:CE11024 rpl-7 encodes a large ribosomal subunit L7 protein required in mass RNAi assays for embryonic viability and normally rapid growth. ribosomal protein F56C11.1 F53G12.2, F56C11.1 bli-3; tag-31; F56C11.1; 1A620; CE28463; NM_058285; WBGene00000253; WP:CE28463 bli-3 encodes a large homolog of dual oxidase ('Ce-Duox1'), with an N-terminal peroxidase domain, two central calmodulin-binding EF hands, and a C-terminal superoxide-generating NADPH-oxidase domain; BLI-3 is required for dityrosine cross-linking of collagen, and thus for cuticular integrity; BLI-3 is thought to use cytosolic NADPH to generate reactive oxygen, which then drives the peroxidase ectodomain to cross-link free tyrosine in collagen; BLI-3 is expressed exclusively in hypodermal cells at low levels, with peaks of expression corresponding to collagen/cuticle biosynthesis. F53G12.3 F53G12.3 F53G12.3; 1A615; CE24999; WBGene00018771; WP:CE24999 F53G12.3 encodes a large partial homolog of dual oxidase ('Ce-Duox2'), with an N-terminal peroxidase domain, two central calmodulin-binding EF hands, and a C-terminal superoxide-generating NADPH-oxidase domain; F53G12.3 may be required for dityrosine cross-linking of collagen, and thus for cuticular integrity; F53G12.3 may use cytosolic NADPH to generate reactive oxygen, which then may drive the peroxidase ectodomain to cross-link free tyrosine in collagen; F53G12.3 has no visible expression pattern detectable by antibodies, implying very low or rare expression. F53G2.2 F53G2.2 F53G2.2; 2C773; CE36862; WBGene00018767; WP:CE36862 F53H2.1 F53H2.1 F53H2.1; 5U859; CE19886; WBGene00010004; WP:CE19886 F53H8.3 F53H8.3 F53H8.3; CE04656; WBGene00018779; WP:CE04656; XB557 glucose transporter F54A5.1 C54G6.4, F54A5.1 F54A5.1; F54A5.E; 1B465; CE20859; WBGene00018786; WP:CE20859 F54B11.10 F54B11.10 F54B11.10; CE05934; WBGene00010033; WP:CE05934; XO197 F54B11.9 F54B11.9 F54B11.9; CE05933; WBGene00010032; WP:CE05933; XO225 F54B3.3 F54B3.3 F54B3.3; 2K539; CE35878; WBGene00010015; WP:CE35878 ATPases associated with various cellular activities (AAA) F54C9.1 F54C9.1 iff-2; F54C9.1; 2I850; CE02249; NM_063406; WBGene00002065; WP:CE02249 initiation factor 5A F54C9.5 F54C9.5 rpl-5; F54C9.5; 2I861; CE02255; NM_063410; WBGene00004416; WP:CE02255 rpl-5 encodes a large ribosomal subunit L5 protein; by homology, RPL-5 is predicted to function in protein biosynthesis; in C. elegans RPL-5 activity is broadly required for embryonic, larval, germline, and vulval development, as well as normal body coloration, morphology, and postembryonic growth rates. 60S ribosomal protein L5 F54C9.7 F54C9.7 F54C9.7; 2I865; CE02257; WBGene00010043; WP:CE02257 F54D1.2 F54D1.2 col-126; F54D1.2; 4M29; CE05937; NM_069714; WBGene00000700; WP:CE05937 collagen F54D1.3 F54D1.3 col-127; F54D1.3; 4M30; CE05938; NM_069715; WBGene00000701; WP:CE05938 collagen F54D11.1 F54D11.1 pmt-2; F54D11.1; 5F113; CE11068; WBGene00018811; WP:CE11068 F54E7.2 F54E7.2 rps-12; F54E7.2; 3G769; CE26896; NM_065820; WBGene00004481; WP:CE26896 rps-12 encodes a small ribosomal subunit S12 protein; by homology, RPS-12 is predicted to function in protein biosynthesis; in C. elegans, RPS-12 activity is required for embryonic and germline development, normal movement, and the overall health of the animal. F54H12.6 F54H12.6 F54H12.6; 3J62; CE00548; WBGene00018846; WP:CE00548 Elongation factor 1 F55A11.7 F55A11.7 F55A11.7; 5M266; CE20873; WBGene00010080; WP:CE20873 F55A12.8 F55A12.8 F55A12.8; 1F918; CE11131; WBGene00018866; WP:CE11131 F55C10.3 F55C10.3 col-155; F55C10.3; 5L868; CE11182; NM_073487; WBGene00000728; WP:CE11182 collagen F55C12.3 F55C12.3 F55C9.3 F55C9.3, Y116F11A.A F55C9.3; 5T762; CE18735; WBGene00010100; WP:CE18735 F55C9.5 F55C9.5, Y116F11A.B F55C9.5; 5T764; CE18737; WBGene00010102; WP:CE18737 F55D10.2 F55D10.2 rpl-25.1; F55D10.2; CE02777; NM_076407; WBGene00004438; WP:CE02777; XF335 rpl-25.1 encodes a large ribosomal subunit L23a protein. Ribosomal protein L23 F55D12.2 F55D12.2 F55D12.2; 1I469; CE32439; WBGene00010111; WP:CE32439 F55F3.4 F55F3.4 F55F3.4; CE18747; WBGene00010118; WP:CE18747; XO407 F55F8.2 F55F8.2 F55F8.2; 1G216; CE11190; CE33400; WBGene00018890; WP:CE11190; WP:CE33400 RNA helicase F55F8.3 F55F8.3 F55F8.3; 1G218; CE30542; WBGene00018891; WP:CE30542 F55G11.5 F55G11.5 dod-22; F55G11.5; 4N731; CE18751; NM_070081; WBGene00010125; WP:CE18751 F55G11.8 F55G11.8 F55G11.8; 4N727; CE18754; WBGene00010128; WP:CE18754 F55G7.2 F55G7.2 F55G7.2; CE03424; WBGene00010120; WP:CE03424; XM546 F55H2.6 F55H2.6 clu-1; F55H2.6; 3K606; CE00213; NM_066696; WBGene00000550; WP:CE00213 clu-1 encodes an ortholog of CLU1/TIF31 in S. cerevisiae, which directs proper cytoplasmic distribution of mitochondria and physically interacts with eukaryotic translation initiation factor 3 (eIF3); worm CLU-1 may be required for the proper distribution of mitochondria, but is dispensable for viability and gross morphology in mass RNAi screens. F56A4.C F56A4.C F56A4.J F56A4.J F56B6.4 F56B6.4 uvt-5; F56B6.4; CE04664; CE29405; CE31185; NM_076207; NM_076208; NM_171944; WBGene00006863; WP:CE04664; WP:CE29405; WP:CE31185; XE161 glycogenin F56C11.1 F53G12.2, F56C11.1 bli-3; tag-31; F56C11.1; 1A620; CE28463; NM_058285; WBGene00000253; WP:CE28463 bli-3 encodes a large homolog of dual oxidase ('Ce-Duox1'), with an N-terminal peroxidase domain, two central calmodulin-binding EF hands, and a C-terminal superoxide-generating NADPH-oxidase domain; BLI-3 is required for dityrosine cross-linking of collagen, and thus for cuticular integrity; BLI-3 is thought to use cytosolic NADPH to generate reactive oxygen, which then drives the peroxidase ectodomain to cross-link free tyrosine in collagen; BLI-3 is expressed exclusively in hypodermal cells at low levels, with peaks of expression corresponding to collagen/cuticle biosynthesis. F56C11.2 F56C11.2 ptr-11; F56C11.2; 1A634; CE17902; NM_058286; WBGene00004225; WP:CE17902 ptr-11 encodes a nematode-specific member of the sterol sensing domain (SSD) proteins, distantly paralogous to Drosophila PATCHED (PTC) and human PTCH (OMIM:601309, mutated in basal cell nevus syndrome); PTR-11 is required for normal growth to full size, locomotion, and vulval morphogenesis. F56C9.6 F56C9.6 F56C9.6; 3I398; CE01325; WBGene00018950; WP:CE01325 F56D1.3 F56D1.3 F56D1.3; CE29407; WBGene00018961; WP:CE29407 F56D1.7 F56D1.5 daz-1; F56D1.7; 2F747; CE27175; NM_062635; WBGene00000935; WP:CE27175 daz-1 encodes a protein containing an RNA recognition motif that is required for the progression of meiosis during oogenesis; expressed in the germline and expression levels peak in the proximal pachytene region. F56D1.6 F56D1.6 cex-1; F56D1.6; 2F739; CE01974; NM_062633; WBGene00018962; WBGene00023407; WP:CE01974 calcium binding protein (weak) F56D12.5 F56D12.5 vig-1; F56D12.5; 2B613; CE11254; CE33404; NM_170973; NM_170974; WBGene00006924; WP:CE11254; WP:CE33404 F56E10.4 F56E10.4 rps-27; F56E10.4; 5A582; CE19904; NM_070733; WBGene00004496; WP:CE19904 rps-27 encodes a small ribosomal subunit S27 protein. ribosomal protein F56F10.1 F56F10.1 F56F10.1; CE34034; WBGene00018984; WP:CE34034; XB493 peptidase F56F3.2 F56F3.2 ndg-4; F56F3.2; 3F554; CE01015; CE33658; NM_065506; WBGene00003577; WP:CE01015; WP:CE33658 F56F3.5 F56F3.5 rps-1; F56F3.5; 3F565; CE00664; NM_065509; RS3A_CAEEL; WBGene00004470; WP:CE00664 rps-1 encodes a small ribosomal subunit S3A protein. Ribosomal protein S3a (human) homolog. F57B1.3 F57B1.3 col-159; F57B1.3; 5N678; CE11290; NM_073882; WBGene00000732; WP:CE11290 collagen F57B1.7 F57B1.7 F57B1.7; 5N702; CE11298; WBGene00010190; WP:CE11298 F57B10.9 F57B10.9 F57B10.9; 1H128; CE30546; WBGene00019006; WP:CE30546 F57B10.9 is orthologous to the human gene SPARTIN (TAHCCP1; OMIM:607111), which when mutated leads to disease. F57B7.3 F57B7.3 col-156; F57B7.3; 5L930; CE05991; NM_073501; WBGene00000729; WP:CE05991 collagen F57B7.4 F57B7.4 mig-17; F57B7.4; 5L929; CE31010; NM_073500; WBGene00003248; WP:CE31010 mig-17 encodes a secreted metalloprotease that is a member of the ADAM (A Disintegrin And Metalloprotease) protein family; MIG-17 activity is required for proper migration of gonadal leader cells, namely the hermaphrodite distal tip cells (DTCs) and the male linker cell (MLC); a MIG-17::GFP translational fusion protein is first detected in late embryos with expression continuing through adulthood; expression is initially seen on the pseudocoelomic face of body wall muscles and then on the surface of the gonad, when the DTCs migrate over the lateral hypodermis towards the dorsal muscles; proper MIG-17 localization and glycosylation requires activity of MIG-23, a membrane-bound nucleoside diphosphatase, as well as activity of COGC-3 and COGC-1, two members of the conserved oligomeric Golgi complex; expression studies with MIG-17 deletion derivatives indicate that MIG-17 is expressed by the body wall muscles and then localizes to the DTCs where its activity is sufficient for guiding DTC migration. zinc metallopeptidase (M12B family) F57B9.5 F57B9.5 byn-1; F57B9.5; 3I25; CE25013; NM_066109; WBGene00000276; WP:CE25013 byn-1 encodes a homolog of mammalian BYSTIN-LIKE (BYSL; OMIM:603871). F57B9.6 F57B9.6 inf-1; F57B9.6; 3I21; CE01341; CE38524; Ce1F; CeIF; NM_066108; WBGene00002083; WP:CE01341; WP:CE38524 inf-1 encodes a protein with high similarity to eukaryotic initiation factor 4A. F57C12.1 F57C12.1 nas-38; F57C12.1; CE31188; NM_075719; WBGene00003554; WP:CE31188; XB181 F57F4.3 F57F4.3 gfi-1; F57F4.3; 5G882; CE11342; NM_072225; WBGene00001581; WP:CE11342 gfi-1 encodes a protein that contains 21 ET modules; interacts with unc-68 in yeast two-hybrid assays. F57F4.4 F57F4.4 F57F4.4; CE11344; NM_072226; WBGene00019017; WP:CE11344 F57F5.3 F57F5.3 F57F5.3; 5M484; CE06001; WBGene00010205; WP:CE06001 F57G8.5 F57G8.5 F57G8.5; 5Q821; CE18777; WBGene00010214; WP:CE18777 F57G8.7 F57G8.7 F57G8.7; 5Q809; CE18778; WBGene00010216; WP:CE18778 F57H12.4 F57H12.4 F57H12.4; 4I737; CE17125; WBGene00019019; WP:CE17125 seven trans-membrane receptor F57H12.6 F57H12.6 F57H12.6; 4I740; CE32447; WBGene00019021; WP:CE32447 F58A4.11 F58A4.11 gei-13; F58A4.11; 3K722; CE40812; NM_066733; WBGene00001570; WP:CE40812 gei-13 encodes a protein, with a BED finger domain (predicted to be DNA-binding) and a glutamine/asparagine-rich domain; GEI-13 physically interacts with GEX-3, and is required for normal body shape, cuticle synthesis, and locomotion. F58B3.3 F58B3.3 lys-6; F58B3.3; 4M392; CE06005; NM_069793; WBGene00003095; WP:CE06005 F58B3.4 F58B3.4 F58B3.4; 4M394; CE36170; WBGene00010231; WP:CE36170 F58E10.7 F58E10.7 F58E10.7; 5O473; CE18789; WBGene00010262; WP:CE18789 F58E2.2 F58E2.2 F58E2.2; 4E235; CE17130; WBGene00019046; WP:CE17130 F58E2.3 F58E2.3 F58E2.3; 4E233; CE17131; WBGene00019047; WP:CE17131 This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins; this gene's encoded protein also contains an FTH/DUF38 motif, which may also mediate protein-protein interaction. F58E6.1 F58E6.2 STAT-B; F58E6.1; CE20893; CE25921; WBGene00010251; WP:CE20893; WP:CE25921 The F58E6.1 encodes a protein that may be involved in apoptosis. F58E6.4 F58E6.4 F58E6.4; 5K230; CE06019; WBGene00010253; WP:CE06019 F58E6.7 F58E6.7 F58E6.7; 5K237; CE38525; WBGene00010256; WP:CE38525 F58F12.2 F58F12.2 F58F12.2; 2G674; CE07305; WBGene00019062; WP:CE07305 F58G1.4 F58G1.4 F58G1.4; 2N223; CE17924; WBGene00010266; WP:CE17924 F58H10.1 F58H10.1 F58H10.1; 1I331; CE36173; WBGene00010291; WP:CE36173 F59A2.3 F59A2.3 F59A2.3; 3E487; CE17940; WBGene00010303; WP:CE17940; YMI3_CAEEL Splicing factor-associated 32K chain F59A7.2 F59A7.2 F59A7.2; 5C494; CE11438; WBGene00019090; WP:CE11438 F59B2.11 F59B2.10 F59B2.11; 3K101; CE37775; WBGene00010313; WP:CE37775 F59B2.6 F59B2.6 tag-6; zif-1; F59B2.6; 3K93; CE34193; NM_066591; WBGene00006977; WP:CE34193; ZIF1_CAEEL zif-1 encodes a SOCS-box protein that promotes establishment of the germ line by targetting germline proteins for cullin-dependent degradation in non-germline (somatic) cells; ZIF-1 binds germline CCCH-(zinc)-finger proteins and the E3 ubiquitin ligase subunit elongin C (ELC-1); while ZIF-1 has no obvious homologs, it may be analogous to the Drosophila SOCS-box protein GUSTAVUS, which is required for VASA localization to the germline and which does have mammalian homologs. F59B8.2 F59B8.2 F59B8.2; 4K204; CE03436; WBGene00010317; WP:CE03436 isocitrate dehydrogenase F59E11.12 F59E11.12 nhr-144; F59E11.12; 5J452; CE33120; CE35888; WBGene00019117; WP:CE33120; WP:CE35888 F59E11.7 F59E11.7 F59E11.7; 5J471; CE11508; CE28568; WBGene00019113; WP:CE11508; WP:CE28568 F59F4.4 F59F4.4 acl-1; F59F4.4; CE11552; NM_078205; WBGene00010339; WP:CE11552; XQ469 acl-1 encodes a 1-acyl-sn-glycerol-3-phosphate acyltransferase; ACL-1 is predicted to be a membrane protein that plays a role in phospholipid biosynthesis, but as loss of acl-1 activity via large-scale RNAi experiments results in no obvious defects, the precise role of ACL-1 in C. elegans development and/or behavior is not yet known. 1-acyl-SN-glycerol-3-phosphate acyltransferase F59F5.2 F59F5.2 F59F5.2; CE26715; WBGene00010341; WP:CE26715; XL153; XL155 H01G02.1 H01G02.1 H01G02.1; 4M564; CE40564; WBGene00010348; WP:CE40564 H04M03.3 H04M03.3 H04M03.3; H04M03.E; 4G657; CE20922; WBGene00019153; WP:CE20922 H06H21.8 H06H21.8 H06H21.8; 4F580; CE17966; CE31705; WBGene00019164; WP:CE17966; WP:CE31705 H06I04.4 H06I04.A, H06I04.F, Y53G8B_1025.A ubl-1; H06I04.4; 3E159; CE20938; CE31022; NM_171089; UBL1_CAEEL; WBGene00006725; WP:CE20938; WP:CE31022 ubl-1 encodes a protein similar to Drosophila ubiquitin/ ribosomal protein S27a that affects body length, fertility, and larval viability. H06I04.4 H06I04.A, H06I04.F, Y53G8B_1025.A ubl-1; H06I04.4; 3E159; CE20938; CE31022; NM_171089; UBL1_CAEEL; WBGene00006725; WP:CE20938; WP:CE31022 ubl-1 encodes a protein similar to Drosophila ubiquitin/ ribosomal protein S27a that affects body length, fertility, and larval viability. H06I04.3 H06I04.H, Y53G8B_1025.C H06I04.3; 3E173; CE23795; CE38200; CE38201; WBGene00019168; WP:CE23795; WP:CE38200; WP:CE38201 H06O01.3 H06O01.3 ctg-1; H06O01.3; 1H585; CE17969; WBGene00010370; WP:CE17969 retinal-binding protein like H11L12.1 H11L12.1 H11L12.1; CE20957; WBGene00019189; WP:CE20957; XS322 H12D21.1 H12D21.1 nspa-1; H12D21.1; 5P366; CE15223; NM_074268; WBGene00010377; WP:CE15223 H12I19.5 H12I19.5 H12I19.5; 4O916; CE16177; CE16178; WBGene00010392; WP:CE16177; WP:CE16178 H13N06.2 H13N06.2 H13N06.2; CE35570; WBGene00010396; WP:CE35570; XQ109 von Willebrand factor type A domain K07D8.1 H14A12.6, K07D8.1 mup-4; K07D8.1; 3I570; CE29511; NM_066244; Q21281_CAEEL; WBGene00003497; WP:CE29511 The mup-4 gene encodes a novel transmembrane protein required for junctional attachments between hypodermis and muscle, and between the apical epithelial surface and the cuticular matrix. H14N18.2 H14N18.2 H14N18.2; 5J413; CE17974; WBGene00019202; WP:CE17974 H16D19.1 H16D19.1 clec-13; H16D19.1; 1N227; CE13381; WBGene00010399; WP:CE13381 Lectin C-type domain short and long forms (2 domains), CUB domain H16D19.2 H16D19.2 clec-14; H16D19.2; 1N229; WBGene00010400 H17B01.3 H17B01.3 H17B01.3; 2B770; CE11594; WBGene00019208; WP:CE11594 H23N18.1 H23N18.1 ugt-13; H23N18.1; H23N18.D; 5F385; CE35331; WBGene00019232; WP:CE35331 7TM chemoreceptor, ugt family H42K12.1 H33H01.A pdk-1; H33H01.A; H42K12.1; CE28739; CE28740; WBGene00003965; WP:CE28739; WP:CE28740; XB945 pdk-1 encodes the C. elegans 3-phosphoinositide-dependent kinase 1 ortholog; PDK-1 is a component of the DAF-2/insulin receptor-like signaling pathway and accordingly, functions to regulate such processes as dauer larvae formation, longevity, and salt chemotaxis learning; genetic analyses indicate that, in regulating dauer arrest, PDK-1 acts downstream of AGE-1/PI3K and upstream of the AKT-1 and AKT-2 kinases; a PDK-1::GFP fusion protein is expressed broadly beginning in late stage embryos and continuing on through adulthood; expression is seen in head, tail, and ventral cord motor neurons, pharyngeal tissues, hypodermal cells, the intestine, and the somatic gonad; in neurons, the PDK-1::GFP localizes to cell bodies and processes, with occasional expression seen in some neuronal nuclei. JC8.3 JC8.3 rpl-12; JC8.3; 4O4; CE17986; CE39743; NM_070141; NM_070142; WBGene00004424; WP:CE17986; WP:CE39743 rpl-12 encodes a large ribosomal subunit L12 protein required in mass RNAi assays for embryonic viability, fertility, normally rapid growth, and general health; the rpl-12 transcription unit has a nonsense transcript that is up-regulated in vivo by smg[-] mutations, indicating that rpl-12 is a natural substrate for SMG-mediated nonsense suppresssion; several other natural mRNA substrates of SMG suppression (e.g., rpl-3, rpl-7, rpl-10) have protein products that are involved in translation. K01A2.4 K01A2.4 K01A2.4; 2A599; CE39022; WBGene00019279; WP:CE39022 K01A2.5 K01A2.5 K01A2.5; 2A593; CE19513; WBGene00019280; WP:CE19513 K01C8.9 K01C8.9 nst-1; K01C8.9; 2I572; CE02270; GNL3_CAEEL; NM_063348; WBGene00003821; WP:CE02270 nst-1 encodes a homolog of human FLJ10613 and nucleostemin (OMIM:608011); nucleostemin is a nucleolar protein found in stem cells that is required in quantitatively correct amounts (neither too little nor too much) for continued cell division and survival by stem cells or transformed cells; NST-1 is required in mass RNAi assays for normally rapid growth, larval viability, and normal body morphology and pigmentation; it is thus possible that NST-1 acts in the nucleolus to maintain cell proliferation. GTP-binding protein K01D12.13 K01D12.13 cdr-7; K01D12.13; 5M890; CE38388; CE38389; WBGene00010472; WP:CE38388; WP:CE38389 glutathione S-transferase K01D12.8 K01D12.8 K01D12.8; 5M883; CE34199; WBGene00010467; WP:CE34199 K01D12.9 K01D12.9 K01D12.9; 5M884; CE06048; WBGene00010468; WP:CE06048 K01G5.5 K01G5.5 K01G5.5; 3L839; CE16195; WBGene00010478; WP:CE16195 The K01G5.5 gene encodes an ortholog of human DYSKERIN (DKC1; OMIM:300126), which when mutated leads to X-linked dyskeratosis congenita (OMIM:305000); the K01G5.5 protein is predicted to be mitochondrial with 68% accuracy. centromere/microtubule binding protein K02B2.5 K02B2.5 rps-25; K02B2.5; 4G712; CE04691; NM_068494; WBGene00004494; WP:CE04691 rps-25 encodes a small ribosomal subunit S25 protein. ribosomal protein K02D3.1 K02D3.1 K02D3.1; CE06069; WBGene00010504; WP:CE06069; XO323 K02E2.4 K02E2.4 ins-35; K02E2.4; 5U845; CE18839; NM_075525; WBGene00002118; WP:CE18839 ins-35 encodes one of several insulin-related peptides. K02E2.7 K02E2.7 K02E2.7; 5U852; CE18842; WBGene00010508; WP:CE18842 K02E7.10 K02E7.10 K02E7.10; 2B354; CE11640; WBGene00019314; WP:CE11640 protease K02E7.7 K02E7.7 K02E7.7; 2B345; CE11634; WBGene00019312; WP:CE11634 K02F2.2 K02F2.2 K02F2.2; 1H413; CE17154; CEAHH; SAHH_CAEEL; WBGene00019322; WP:CE17154 S-adenosylhomocysteine hydrolase K02F3.3 K02F3.3 far-8; K02F3.3; 3B461; CE34046; NM_064872; WBGene00001392; WP:CE34046 K02H11.4 K02H11.4 K02H11.4; 5C2; CE18002; WBGene00019348; WP:CE18002 K03A11.4 K03A11.4 K03A11.4; CE34048; WBGene00010521; WP:CE34048; XN699 K03B4.7 K03B4.7 cpg-8; K03B4.7; 5F170; CE28581; CE33133; WBGene00019357; WP:CE28581; WP:CE33133 K03B8.7 K03B8.7 grl-3; K03B8.7; 5L889; CE06081; NM_073495; WBGene00001712; WP:CE06081 grl-3 encodes a hedgehog-like protein, with an N-terminal signal sequence, a central low-complexity region, and a C-terminal Ground-like (Grl) domain; GRL-3 is expressed in intestine, larval renal gland cells, and larval neurons; the Grl domain is predicted to form a cysteine-crosslinked protein involved in intercellular signalling, and it has subtle similarity to the N-terminal Hedge domain of HEDGEHOG proteins. K03D3.2 K03D3.2 K03D3.2; 4R86; CE16208; WBGene00010528; WP:CE16208 K03D3.3 K03D3.3 srz-21; K03D3.3; 4R84; NM_070542; WBGene00010529 K03H1.5 K03H1.5 K03H1.5; 3L27; CE03459; WBGene00010540; WP:CE03459 Transmembrane and sushi domain K03H6.2 K03H6.2 K03H6.2; 4C279; CE39583; WBGene00019368; WP:CE39583 K04C2.2 K04C2.2 K04C2.2; 3H983; CE00722; WBGene00019380; WP:CE00722 K04D7.1 K04D7.1 rack-1; K04D7.1; 4K941; CE06090; GBLP_CAEEL; WBGene00010556; WP:CE06090 guanine nucleotide-binding protein K04E7.2 K04E7.2 opt-2; pep-2; K04E7.2; CE25039; NM_076686; WBGene00003877; WP:CE25039; XH79 Oligopeptide transporter K04F1.9 K04F1.9 K04F1.9; 5C139; CE19960; WBGene00019388; WP:CE19960 K05B2.4 K05B2.4 K05B2.4; CE35738; WBGene00019404; WP:CE35738; XF534 K05C4.5 K05C4.5 K05C4.5; 1P339; CE19973; WBGene00010582; WP:CE19973 K05F1.6 K05F1.6 K05F1.6; 2G77; CE37028; CE37029; WBGene00019408; WP:CE37028; WP:CE37029 K05F6.4 K05F6.4 K05F6.4; 2B837; CE17162; WBGene00019415; WP:CE17162 This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins; its encoded protein also contains a Pfam-B45 motif of presently unknown function. K06A9.1 K06A9.1 K06A9.1; CE19524; CE19525; CE34576; WBGene00019435; WP:CE19524; WP:CE19525; WP:CE34576; XC177 The K06A9.1 gene encodes an homolog of human TCOF1, which when mutated leads to Treacher-Collins syndrome (OMIM:154500). K07A1.13 K07A1.13 K07A1.13; 1K160; CE18857; WBGene00010617; WP:CE18857 K07A1.7 K07A1.7 K07A1.7; 1K172; CE11852; WBGene00010614; WP:CE11852 K07B1.1 K07B1.1 try-5; K07B1.1; 5J829; CE35334; NM_073020; WBGene00006623; WP:CE35334 K07B1.4 K07B1.4 K07B1.4; 5J811; CE11882; CE27391; WBGene00019464; WP:CE11882; WP:CE27391 K07C11.4 K07C11.4 K07C11.4; 5I685; CE07347; Q21266_CAEEL; WBGene00019477; WP:CE07347 esterase K07C5.4 K07C5.4 K07C5.4; 5K832; CE06114; WBGene00010627; WP:CE06114 yeast protein L8167.9-like K07C6.3 K07C6.3 cyp-35B2; K07C6.3; 5E421; CE17174; NM_071693; WBGene00019471; WP:CE17174 cytochrome P450 K07C6.4 K07C6.4 ccp-35B1; cyp-35B1; dod-13; K07C6.4; 5E419; CE17175; NM_071692; WBGene00019472; WP:CE17175 cytochrome P450 K07D8.1 H14A12.6, K07D8.1 mup-4; K07D8.1; 3I570; CE29511; NM_066244; Q21281_CAEEL; WBGene00003497; WP:CE29511 The mup-4 gene encodes a novel transmembrane protein required for junctional attachments between hypodermis and muscle, and between the apical epithelial surface and the cuticular matrix. K07E3.7 K07E3.6, K07E3.7 K07E3.7; CE37253; CE37254; WBGene00019493; WP:CE37253; WP:CE37254; XI710 K07E3.7 K07E3.6, K07E3.7 K07E3.7; CE37253; CE37254; WBGene00019493; WP:CE37253; WP:CE37254; XI710 K07G5.5 K07G5.5 K07G5.5; 1H747; CE06133; WBGene00010644; WP:CE06133 K07H8.10 K07H8.10 K07H8.10; 4J52; CE18030; WBGene00019510; WP:CE18030 RNA-binding protein K08C7.3 K08C7.3 egf-3; epi-1; lgx-3; K08C7.3; 4L443; CE06136; CE25049; NM_069569; WBGene00001328; WP:CE06136; WP:CE25049 epi-1 encodes a laminin alpha chain that affects oogenesis due to its affect on gonad development, and also affects cell migrations, axon extension and GABAergic defasciculation, morphology of the VD and DD motor neurons, body morphology, locomotion, gonad sheath epithelialization, body muscle structure, and germ cell proliferation. laminin K08C7.5 K08C7.5 fmo-12; fmo-2; K08C7.5; 4L447; CE06138; NM_069571; WBGene00001477; WP:CE06138 flavin-containing monoxygenase K08C9.4 K08C9.4 col-65; K08C9.4; 1M82; CE18860; NM_060535; WBGene00000641; WP:CE18860 K08D10.10 K08D10.10 K08D10.10; 4E925; CE07362; WBGene00019533; WP:CE07362 K08D12.6 K08D12.E K08D12.6; 4C487; CE21047; WBGene00019540; WP:CE21047 K08D8.4 K08D8.4 K08D8.4; 4N674; CE38085; CE38086; CE38087; CE38088; WBGene00010658; WP:CE38085; WP:CE38086; WP:CE38087; WP:CE38088 K08D9.2 K08D9.2 K08D9.2; 5D707; CE19982; WBGene00019524; WP:CE19982 K08D9.5 K08D9.5 K08D9.5; 5D702; CE19985; WBGene00019526; WP:CE19985 K08D9.6 K08D9.6 K08D9.6; 5D710; CE32199; WBGene00019527; WP:CE32199 K08E3.1 K08E3.1 tyr-2; K08E3.1; 3O835; CE18864; NM_067435; WBGene00010661; WP:CE18864 tyrosinase K08E7.5 K08E7.5 K08E7.5; 4N343; CE11924; CE39390; CE39392; CE39747; Q21344_CAEEL; WBGene00010673; WP:CE11924; WP:CE39390; WP:CE39392; WP:CE39747 K08F11.6 K08F11.6 K08F11.6; 4F492; WBGene00023323 K08F4.11 K08F4.11 gst-3; K08F4.11; 4K902; CE25050; CeGST3; GST3_CAEEL; NM_069445; WBGene00001751; WP:CE25050 gst-3 encodes a predicted glutathione S-transferase. glutathione S-transferase K08H2.1 K08H2.1 skr-21; K08H2.1; CE06159; NM_077793; WBGene00004827; WP:CE06159; XN844 The skr-21 gene encodes a homolog of Skp1 in S. cerevisiae that has no known function in vivo, since skr-21(RNAi) animals are at least superficially normal. RNA polymerase II elongation factor like K09A11.2 K09A11.2 cyp-14A1; K09A11.2; CE03473; NM_077802; WBGene00010705; WP:CE03473; XN884 cytochrome p450 K09A11.3 K09A11.3 cyp-14A2; tag-190; K09A11.3; CE03474; NM_077803; WBGene00010706; WP:CE03474; XN886 Cytochrome P450 K09A11.4 K09A11.4 cyp-14A3; K09A11.4; CE03475; NM_077804; WBGene00010707; WP:CE03475; XN890 cytochrome p450 K09C4.1 K09C4.1 K09C4.1; CE04729; CE39595; WBGene00019547; WP:CE04729; WP:CE39595; XD919 glucose transporter K09C4.4 K09C4.4 K09C4.4; CE04732; WBGene00019549; WP:CE04732; XD909 sugar transporter K09C4.5 K09C4.5 K09C4.5; CE37126; WBGene00019550; WP:CE37126; XD905 sugar transporter K09C6.5 K09C6.5 srbc-13; K09C6.5; 5B325; CE11996; NM_070939; WBGene00019559; WP:CE11996 7TM chemoreceptor, srbc family K09D9.1 K09D9.1 K09D9.1; 5E499; CE21055; WBGene00019564; WP:CE21055 K09D9.9 K09D9.9 K09D9.9; 5E470; CE21063; WBGene00019567; WP:CE21063 K09E2.1 K09E2.1 K09E2.1; CE40092; WBGene00019570; WP:CE40092; XJ299 K09E2.3 K09E2.3 K09E2.3; CE02816; WBGene00019572; WP:CE02816; XJ293 K09H9.6 K09H9.6 lpd-6; K09H9.6; 1D714; CE37030; NM_058707; WBGene00003062; WP:CE37030 lpd-6 encodes a predicted rRNA-binding protein that is orthologous to Drosophila Peter Pan and the Saccharomyces cerevisiae SSF1 and SSF2 proteins that are required for ribosomal large subunit maturation; loss of lpd-6 activity via RNAi indicates that, in C. elegans, LPD-6 is required for fat storage and for larval growth and development; based upon its similarity to yeast SSF1 and SSF2, LPD-6 is predicted to be a nucleolar protein. K10C2.1 K10C2.1 K10C2.1; CE37128; WBGene00019617; WP:CE37128; XH40 serine carboxypeptidase K10C3.5 K10C3.5 K10C3.5; 1K443; CE32469; CE38396; WBGene00010732; WP:CE32469; WP:CE38396 elongation factor EF-2 like K10C8.2 K10C8.2 K10C8.2; 5N169; CE06168; WBGene00010735; WP:CE06168 K10C8.2 encodes a homolog of the functionally active Fmrf Receptor (FR; CG2114) of D. melanogaster; it is thus possible that K10C8.2 is a receptor for one of the FMRF-like neurotransmitters in C. elegans (e.g., FLP-1 through FLP-12). G-protein coupled receptor K10D11.1 K10D11.1 dod-17; K10D11.1; 4N741; CE35589; NM_070085; WBGene00010745; WP:CE35589 K10H10.2 K10H10.2 K10H10.2; 2O780; CE16252; O45679_CAEEL; WBGene00010759; WP:CE16252 beta-synthase K10H10.4 K10H10.4 K10H10.4; 2O787; CE16254; WBGene00010760; WP:CE16254 K11D12.4 K11D12.4 cpt-4; K11D12.4; 5F502; CE12132; WBGene00019644; WP:CE12132 acetyltransferase K11D12.8 K11D12.8 K11D12.8; 5F518; CE12140; WBGene00019648; WP:CE12140 K11G9.1 K11G9.1 K11G9.1; 5H159; CE07374; WBGene00019652; WP:CE07374 esterase K11G9.6 K11G9.6 met-I; mtl-1; K11G9.6; 5H172; CE07379; NM_072295; WBGene00003473; WP:CE07379 K11H12.1 K11H12.1 K11H12.1; 4B404; CE12146; WBGene00019658; WP:CE12146 DNA-binding protein K11H12.2 K11H12.2 rpl-15; K11H12.2; 4B406; CE12148; NM_067563; WBGene00004427; WP:CE12148 rpl-15 encodes a large ribosomal subunit L15 protein. 60S ribosomal protein L15 K11H12.4 K11H12.4 K11H12.4; 4B428; CE12152; WBGene00019660; WP:CE12152 K12H4.3 K12H4.3 K12H4.3; 3J135; CE00268; WBGene00019678; WP:CE00268 K12H4.7 K12H4.7 K12H4.7; 3J138; CE32696; CE32697; WBGene00019682; WP:CE32696; WP:CE32697; YM67_CAEEL M01E11.5 M01E11.5 cey-3; M01E11.5; 1G140; CE12296; NM_059230; WBGene00000474; WP:CE12296 cey-3 encodes a protein with a cold-shock/Y-box domain; it is predicted to be mitochondrial by phylogenetic profiling. M01F1.2 M01F1.2 rpl-16; M01F1.2; 3E592; CE01030; NM_065320; WBGene00004428; WP:CE01030 rpl-16 encodes a large ribosomal subunit L13a protein. L13P family ribosomal protein M02D8.1 M02D8.1 M02D8.1; CE04757; Q21465_CAEEL; WBGene00019727; WP:CE04757; XJ383 M02F4.1 M02F4.4 M02F4.1; CE04762; WBGene00019735; WP:CE04762; XD646 M03B6.2 M03B6.2 M03B6.2; CE12336; WBGene00010834; WP:CE12336; XO475 monocarboxylate transporter like M03B6.3 M03B6.3 M03B6.3; CE23873; WBGene00010835; WP:CE23873; XO480 M03E7.2 M03E7.2 M03E7.2; 5G99; CE07395; WBGene00019754; WP:CE07395 M03F8.1 M03F8.1 M03F8.1; 5G433; CE12372; WBGene00019761; WP:CE12372 M05D6.5 M05D6.5 M05D6.5; 2I770; CE03503; WBGene00010878; WP:CE03503 M05D6.7 M05D6.7 gbh-2; M05D6.7; 2I777; CE35896; NM_063392; WBGene00001523; WP:CE35896 gbh-2 encodes an ortholog of human gamma butyrobetaine hydroxilase 2 involved in carnitine biosynthesis; RNA interference of gbh-2 results in malformation of the gonad and accumulation of fat in the pseudocoelomic cavity and in intestinal cells; the GBH-2-GFP fusion protein is predominantly expressed in intestinal cells from early embryogenesis. gamma-butyrobetaine,2-oxoglutarate dioxygenase M106.4 M106.4 M106.4; 2L154; CE18084; CE35897; CE40394; GUAA_CAEEL; WBGene00010912; WP:CE18084; WP:CE35897; WP:CE40394 M106.4 is orthologous to human GUANINE MONOPHOSPHATE SYNTHETASE (GMPS; OMIM:600358), a partner gene of MLL in treatment-related acute myeloid leukemia with the karyotype t(3;11)(q25;q23). M110.5 M110.5 dab-1; M110.5; 2I519; CE36393; CE36446; CE37844; CE40986; NM_063329; NM_063330; NM_063331; Q9U3A6_CAEEL; WBGene00000894; WP:CE36393; WP:CE36446; WP:CE37844; WP:CE40986 dab-1 encodes an ortholog of the cytoplasmic adaptor protein DISABLED, required for normal molting and meiotic arrest; DAB-1 is also required for EGL-17 secretion from vulval cells, and thus indirectly for normal sex myoblast (SM) migration and egg-laying; DAB-1 contains a conserved PTB domain and signals that confer localization to Golgi-proximal vesicles, and DAB-1 localizes to vesicular structures in vivo; dab-1 is expressed in ventral precursor cells, and DAB-1 prevents EGL-17 protein accumulation in them; dab-1 is also expressed in other cells (anchor cell, sheath cells, etc.) but has no obvious function in them; DAB-1 binds the cytoplasmic domains of either LRP-1 or LRP-2 in yeast two-hybrid experiments; dab-1(gk291) and dab-1(RNAi) animals have similar defects in molting, EGL-17 secretion from VPCs, SM migration, and egg-laying; dab-1(RNAi) does not enhance the SM phenotypes of lrp-1(RNAi) or lrp-2(RNAi), suggesting that these genes act in concert to promote normal EGL-17 secretion and SM migration; in vitro, DAB-1 binds to the ear domains of APT-4 (strongly) and of APT-1 and APT-9 (weakly); genetically, dab-1(RNAi) functions as part of the vab-1 pathway in oocytes inhibiting meiotic maturation, and DAB-1 is found in oocyte cytoplasm. M142.2 M142.2 cut-6; M142.2; 3M5; CE35746; NM_066999; WBGene00000853; WP:CE35746 cuticulin M163.1 M163.1 M163.1; CE12446; WBGene00010935; WP:CE12446; XP122 M176.8 M176.8 M176.8; 2J728; CE12474; WBGene00010945; WP:CE12474 chitinase M195.1 M195.1 col-77; M195.1; 2I648; CE03514; NM_063358; WBGene00000653; WP:CE03514 cuticle collagen M28.5 M28.5 phi-9; M28.5; 2K948; CE02283; SNU13CE; WBGene00010896; WP:CE02283 ribosomal protein (L7AE family) M6.1 M6.1 ifc-2; M6.1; CE31204; CE31205; CE34062; Cel IF C2; CelIF c2; NM_171613; NM_171614; WBGene00002056; WP:CE31204; WP:CE31205; WP:CE34062; XB262 ifc-2 encodes three isoforms of an intermediate filament protein dispensable for viability but required for normal movement, growth rate, body size, body shape, and cuticle strength; IFC-2 is present in the cytoplasm of intestinal cells, and at the desmosomes of intestinal and pharyngeal cells. M60.2 M60.1, M60.2 M60.2; CE28630; WBGene00019779; WP:CE28630; XI865 M60.2 M60.1, M60.2 M60.2; CE28630; WBGene00019779; WP:CE28630; XI865 M7.12 M7.12 M7.12; 4L860; CE37394; WBGene00010887; WP:CE37394 R01E6.3 R01E6.3 cah-4; R01E6.3; CE29433; CE29434; NM_077863; NM_077864; WBGene00000282; WP:CE29433; WP:CE29434; XO161 cah-4 encodes a carbonic anhydrase homolog, which is rather divergent from other such homologs in C. elegans (with at most 38% identity to any other carbonic anhydrase, in or out of C. elegans); it is individually dispensable for viability and for grossly normal postembryonic morphology, and thus may have a more subtle biological function than the basic cytoprotective functions expected for carbonic anhydrases. carbonic anhydrase R02D3.1 R02D3.1 R02D3.1; 4B3; CE18095; WBGene00019819; WP:CE18095 The R02D3.1 gene encodes an ortholog of the human gene ALPHA-AMINOADIPATE SEMIALDEHYDE SYNTHASE (AASS; OMIM:605113), which when mutated leads to hyperlysinemia (OMIM:238700). dehydrogenase R02F2.7 R02F2.7 R02F2.7; 3G570; CE29818; WBGene00019836; WP:CE29818 R03D7.1 R03D7.1 R03D7.1; 2L219; CE01609; METH_CAEEL; WBGene00010988; WP:CE01609 R03D7.1 is orthologous to the human gene METHIONINE SYNTHASE (MTR; OMIM:156570), which when mutated leads to disease. 5-methyltetrahydrofolate-homocysteine methyltransferase R03D7.5 R03D7.5 R03D7.5; 2L239; CE35899; WBGene00010991; WP:CE35899 serine/threonine kinase R03D7.6 R03D7.6 gst-5; R03D7.6; 2L241; CE01613; GST5_CAEEL; NM_063956; WBGene00001753; WP:CE01613 glutathione S-transferase R03H4.1 R03H4.1 R03H4.1; 5J499; CE17199; WBGene00019849; WP:CE17199 R03H4.2 R03H4.2 srx-2; R03H4.2; 5J487; CE07405; NM_072929; WBGene00005893; WP:CE07405 7TM chemoreceptor, srx family R03H4.4 R03H4.4 srt-18; R03H4.4; 5J492; CE37925; NM_072931; WBGene00019850; WP:CE37925 7TM chemoreceptor, srt family R03H4.5 R03H4.5 R03H4.5; 5J500; CE07408; WBGene00019851; WP:CE07408 R04B5.6 R04B5.6 R04B5.6; 5K567; CE06216; WBGene00011004; WP:CE06216 sorbitol dehydrogenase R04E5.10 R04E5.10 ifd-1; R04E5.10; CE30100; CE33933; IF D1; IFD1_CAEEL; WBGene00002057; WP:CE30100; WP:CE33933; XJ442 ifd-1 encodes two isoforms of a nonessential intermediate filament protein; IFD-1 is predicted to function as a structural component of the cytoskeleton; IFD-1 has no obvious function in RNAi assays. R05A10.4 R05A10.4 R05A10.4; 4O937; CE16290; WBGene00011021; WP:CE16290 R05A10.6 R05A10.6 R05A10.6; 4O933; CE36187; WBGene00011023; WP:CE36187 R05G9R.1 R05G9R.A R05G9R.1; 2G800; CE39952; WBGene00019906; WP:CE39952 R06B10.1 R06B10.1 R06B10.1; 3B582; CE17200; WBGene00019912; WP:CE17200 protein-tyrosine phosphatase R06B9.1 R06B9.1 R06B9.1; 2O55; CE35900; O17981_CAEEL; WBGene00011052; WP:CE35900 dihydroxyvitamin D3-induced protein R07B1.5 R07B1.5 R07B1.5; CE01631; WBGene00011077; WP:CE01631; XK483 R07B7.6 R07B7.6 R07B7.6; 5M554; CE37399; WBGene00011090; WP:CE37399 acetylglucosaminyltransferase-like domain R07C12.1 R07C12.1 R07C12.1; 4E919; CE17204; WBGene00019931; WP:CE17204 R07E3.3 R07E3.3 cut-5; R07E3.3; CE40396; WBGene00011104; WP:CE40396; XK952 cuticulin R07E3.7 R07E3.7 R07E3.7; CE02301; Q21813_CAEEL; WBGene00011108; WP:CE02301; XK960 R07E5.10 R07E5.10 pdcd-2; R07E5.10; 3F508; CE03534; CE18125; WBGene00011116; WP:CE03534; WP:CE18125 This gene encodes a homolog of mammalian PROGRAMMED CELL DEATH 2 (PDCD2). Apoptosis protein RP-8 R07E5.4 R07E5.4 R07E5.4; 3F485; CE40336; WBGene00011112; WP:CE40336 Glutaredoxin R07G3.6 R07G3.6 R07G3.6; 2H894; CE02025; WBGene00019942; WP:CE02025 R07H5.10 R07H5.10 R07H5.10; 4L978; CE28637; WBGene00011130; WP:CE28637 R07H5.8 R07H5.8 R07H5.8; 4L974; CE12564; Q93934_CAEEL; WBGene00011128; WP:CE12564 adenosine kinase R07H5.9 R07H5.9 R07H5.9; 4L975; CE39953; WBGene00011129; WP:CE39953 R09A8.4 R09A8.4 col-182; R09A8.4; CE03540; NM_077709; WBGene00000755; WP:CE03540; XN254 cuticle collagen R09B3.2 R09B3.2 R09B3.2; 1M500; CE16307; WBGene00011155; WP:CE16307 RNA recognition motif. (aka RRM, RBD, or RNP domain) R09B3.3 R09B3.3 R09B3.3; 1M502; CE16308; WBGene00011156; WP:CE16308 RNA recognition motif. (aka RRM, RBD, or RNP domain) R09B5.11 R09B5.11 R09B5.11; 5B919; CE30296; WBGene00019979; WP:CE30296 sugar transporter R09B5.6 R09B5.6 hacd-1; R09B5.6; 5B939; CE12628; O44608_CAEEL; WBGene00019978; WP:CE12628 3-hydroxyacyl-CoA dehydrogenase R09B5.9 R09B5.9 cnc-4; R09B5.9; 5B925; CE12634; NM_071015; WBGene00000558; WP:CE12634 R09D1.11 R09D1.11 R09D1.11; 2J758; CE06282; WBGene00011167; WP:CE06282 chitinase R09D1.12 R09D1.12 R09D1.12; 2J742; CE28068; WBGene00011168; WP:CE28068 tyrosine-protein kinase (KIN15/KIN16 subfamily) R09E10.1 R09E10.1 R09E10.1; 4L84; CE35599; WBGene00011171; WP:CE35599 R10D12.4 R10D12.4 srx-10; R10D12.4; 5O426; CE36316; NM_074058; WBGene00005901; WP:CE36316 7TM receptor, srx family R10D12.9 R10D12.9 R10D12.9; 5O435; CE40994; WBGene00011190; WP:CE40994 R10E8.6 R10E8.6 R10E8.6; 5S744; CE23924; WBGene00011212; WP:CE23924 This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins; this gene's encoded protein also contains an FTH/DUF38 motif, which may also mediate protein-protein interaction. R11A5.6 R11A5.6 R11A5.6; 1I442; CE12732; WBGene00011234; WP:CE12732 R11A5.7 R11A5.7 R11A5.7; 1I448; CE32478; WBGene00011235; WP:CE32478 zinc carboxypeptidase R11D1.8 R11D1.8 rpl-28; R11D1.8; 5N208; CE06313; NM_073779; RL28_CAEEL; WBGene00004442; WP:CE06313 rpl-28 encodes a large ribosomal subunit L28 protein. ribsomal protein L28 like R11G11.2 R11G11.2 nhr-58; R11G11.2; 5B11; CE12742; CE33298; NM_070835; WBGene00003648; WP:CE12742; WP:CE33298 zinc finger protein R12E2.11 R12E2.11 R12E2.11; 1E740; CE18143; WBGene00020036; WP:CE18143 purine/pyrimidine phosphoribosyl transferase R12E2.14 R12E2.14 R12E2.14; 1E719; CE18146; WBGene00020039; WP:CE18146 R12E2.15 R12E2.15 R12E2.15; 1E716; CE18147; WBGene00020040; WP:CE18147 R12E2.7 R12E2.7 R12E2.7; 1E722; CE18139; WBGene00020033; WP:CE18139 R12E2.9 R12E2.9 inx-15; opu-15; R12E2.9; 1E728; CE18141; NM_058912; WBGene00002137; WP:CE18141 R13A5.12 R13A5.12, R13A5.13 lpd-7; R13A5.12; 3I663; CE21123; NM_066260; WBGene00003063; WP:CE21123 lpd-7 encodes a BRCT domain-containing protein that is orthologous to Saccharomyces cerevisiae Nop7p and the vertebrate pescadillo proteins required for nucleolar assembly, ribosome biogenesis, and cell proliferation; loss of lpd-7 activity via RNAi indicates that, in C. elegans, LPD-7 is required for fat storage and for larval growth and development; based upon its similarity to the yeast and vertebrate proteins, LPD-7 is predicted to localize to the nucleolus. R13A5.12 R13A5.12, R13A5.13 lpd-7; R13A5.12; 3I663; CE21123; NM_066260; WBGene00003063; WP:CE21123 lpd-7 encodes a BRCT domain-containing protein that is orthologous to Saccharomyces cerevisiae Nop7p and the vertebrate pescadillo proteins required for nucleolar assembly, ribosome biogenesis, and cell proliferation; loss of lpd-7 activity via RNAi indicates that, in C. elegans, LPD-7 is required for fat storage and for larval growth and development; based upon its similarity to the yeast and vertebrate proteins, LPD-7 is predicted to localize to the nucleolus. R13A5.8 R13A5.8 rpl-9; R13A5.8; 3I662; CE01380; NM_066259; RL9_CAEEL; WBGene00004420; WP:CE01380 rpl-9 encodes a large ribosomal subunit L9 protein that affects fertility and embryonic viability. Ribosomal protein L9 R13D7.7 R13D7.7 gst-41; R13D7.7; 5H878; CE28770; NM_072493; WBGene00001789; WP:CE28770 glutathione S-transferase R13H4.7 R13H4.7 R13H4.7; 5M344; CE40110; WBGene00011265; WP:CE40110 R148.7 R148.7 R148.7; 3E284; CE40714; WBGene00020105; WP:CE40714 R151.2 R151.2 R151.2; 3I303; CE00745; CE29454; CE29987; CE37138; Q21994_CAEEL; WBGene00020107; WP:CE00745; WP:CE29454; WP:CE29987; WP:CE37138 R151.2 is orthologous to the human gene PHOSPHORIBOSYL PYROPHOSPHATE SYNTHETASE 1 (PRPS1; OMIM:311850), which when mutated leads to disease R151.3 R151.3 rpl-6; R151.3; 3I299; CE00744; NM_066183; WBGene00004417; WP:CE00744 rpl-6 encodes a large ribosomal subunit L6 protein. Ribosomal protein ML16 R52.7 R52.7 srh-195; R52.7; 2C402; CE21126; NM_061785; WBGene00005408; WP:CE21126 7TM chemoreceptor, srh family R74.2 R74.2 R74.2; 3F279; CE23931; WBGene00011278; WP:CE23931 R90.4 R90.4 R90.4; 5N388; CE06328; WBGene00011286; WP:CE06328 Transthyretin-like family T01B10.2 T01B10.2 grd-14; T01B10.2; CE07456; NM_077040; WBGene00001703; WP:CE07456; XJ117 grd-14 encodes a hedgehog-like protein, with an N-terminal signal sequence and a C-terminal Ground domain; the Ground domain is predicted to form a cysteine-crosslinked protein involved in intercellular signalling, and it has subtle similarity to the N-terminal Hedge domain of HEDGEHOG proteins; GRD-14 is required for normal growth to full size, locomotion, and vulval morphogenesis; all of these requirements may reflect common defects in cholesterol-dependent hedgehog-like signalling or in vesicle trafficking. T01B11.7 T01B11.6 oat-1; T01B11.7; 4J230; CE30160; NM_069041; WBGene00003837; WP:CE30160 oat-1 encodes a transmembrane organic anion transporter; although loss of oat-1 activity via large-scale RNAi screens results in no obvious abnormalities, when expressed in mammalian cells OAT-1 can transport a variety of structurally diverse organic anions via an anion exchange mechanism that is functionally coupled to a sodium-coupled dicarboxylate transporter; by homology with mammalian OAT1 transporters, C. elegans OAT-1 is predicted to function in xenobiotic elimination. transmembrane transporter T01B7.7 T01B7.7 rol-6; T01B7.7; 2J23; CE03591; NM_063457; WBGene00004397; WP:CE03591 The rol-6 gene encodes a cuticle collagen related to human collagen alpha 1 (III) chain precursor (OMIM:120180), and is required for normal cuticular morphology; ROL-6 interacts with SQT-1, a closely related cuticle collagen, and is expressed at all stages from L2 to adult with transcripts detected at each of the molts preceding these stages. cuticle collagen ROL-6 T01C3.6 T01C3.6 rps-16; T01C3.6; 5P480; CE12918; NM_074289; WBGene00004485; WP:CE12918 rps-16 encodes a small ribosomal subunit S16 protein. 40S ribosomal protein S16 T01C3.7 T01C3.7 fib-1; T01C3.7; 5P482; CE12920; NM_074290; WBGene00001423; WP:CE12920 fibrillarin T01E8.6 T01E8.6 T01E8.6; 2K532; CE32923; WBGene00011334; WP:CE32923 mitochondrial ribosomal protein S14 T01G9.3 T01G9.3 T01G9.3; 1I859; CE06340; WBGene00011345; WP:CE06340 leucine rich repeats T02B5.1 T02B5.1 T02B5.1; 5O644; CE27775; WBGene00011362; WP:CE27775 carboxylesterase T02E9.2 T02E9.2 grl-7; T02E9.2; 5L826; CE13064; CE38539; NM_073481; O18015_CAEEL; WBGene00001716; WP:CE13064; WP:CE38539 grl-7 encodes a hedgehog-like protein, with an N-terminal signal sequence, a central low-complexity region, and a C-terminal Ground-like (Grl) domain; GRL-7 is expressed in intestine, hypodermis, and seam cells; the Grl domain is predicted to form a cysteine-crosslinked protein involved in intercellular signalling, and it has subtle similarity to the N-terminal Hedge domain of HEDGEHOG proteins. T02G5.2 T02G5.2 T02G5.2; 2H385; CE39397; WBGene00020162; WP:CE39397 T02G5.9 T02G5.9 krs-1; T02G5.9; 2H362; CE04861; CE28247; CE38540; NM_063052; NM_063053; WBGene00002238; WP:CE04861; WP:CE28247; WP:CE38540 lysyl-tRNA synthetase T02H7.1 T02H7.1 T03F1.6 T03F1.6 T03F1.6; 1E408; CE13106; CE28248; WBGene00020188; WP:CE13106; WP:CE28248 T03F7.1 T03F7.1 snf-11; T03F7.1; 5L784; CE40659; NM_073472; WBGene00004910; WP:CE40659 Na(+)/Cl(-)-dependent GABA transporter T03G6.3 T03G6.3 T03G6.3; CE28075; WBGene00020195; WP:CE28075; XD230 plasma cell membrane protein and phosphodiesterase I (weak) T04A11.4 T04A11.4 T04A11.4; 4N248; WBGene00011419 T04A8.5 T04A8.5 T04A8.5; 3F781; CE01074; WBGene00011407; WP:CE01074 Amidophosphoribosyltransferase T04A8.6 T04A8.6 T04A8.6; 3F782; CE01075; WBGene00011408; WP:CE01075 ribonuleoprotein T04C12.2 T04C12.2 srh-75; T04C12.2; 5L536; CE36010; CE36011; WBGene00005296; WP:CE36010; WP:CE36011 T04H1.9 T04H1.9 tbb-6; T04H1.9; 5M743; CE36500; NM_073674; WBGene00006539; WP:CE36500 tubulin beta-chain T05A8.6 T05A8.6 T05A8.6; 2D30; CE18202; WBGene00020232; WP:CE18202 T05B9.1 T05B9.1 T05B9.1; 2L548; CE02310; WBGene00011464; WP:CE02310 T05C1.3 T05C1.3 T05C1.3; 2E776; CE02861; WBGene00020250; WP:CE02861 T05D4.4 T05D4.4 T05D4.4; 3O667; CE34087; WBGene00011477; WP:CE34087 T05E11.1 T05E11.1 rps-5; T05E11.1; 4L874; CE06360; NM_069676; RS5_CAEEL; WBGene00004474; WP:CE06360 rps-5 encodes a small ribosomal subunit S5 protein. 40S ribosomal protein S5 T05E11.8 T05E11.8 T05E11.8; 4L870; CE06367; WBGene00011484; WP:CE06367 T05E7.1 T05E7.1 T05E7.1; 1G781; CE13231; WBGene00020258; WP:CE13231 T05F1.10 T05F1.10 dhs-4; T05F1.10; 1K224; CE26900; NM_060162; WBGene00000968; WP:CE26900 dhs-4 encodes a short-chain dehydrogenase predicted to be mitochondrial. Alcohol/other dehydrogenases, short chain type T05G5.10 T05G5.10 iff-1; T05G5.10; 3K836; CE37787; IF5A1_CAEEL; NM_066751; WBGene00002064; WP:CE37787 iff-1 encodes an eIF-5A homolog that affects fertility and is required for germ cell proliferation and for some P granule components to localize properly; expression is germline specific and mRNA is expressed in the distal region of gonads where germ cells actively proliferate. Initiation factor 5A T06A1.5 T06A1.5 T06A1.5; 5C409; CE18209; WBGene00020280; WP:CE18209 T06A4.3 T06A4.3 T06A4.3; 1B243; CE37044; CE37045; WBGene00020283; WP:CE37044; WP:CE37045 carboxypeptidase T06C12.10 T06C12.10 cgt-1; tag-217; T06C12.10; 5Q366; CE31986; WBGene00011517; WP:CE31986 T06D8.10 T06D8.10 T06D8.10; 2L532; CE13311; WBGene00011530; WP:CE13311 peroxidase T06D8.5 T06D8.5 T06D8.5; 2L522; CE02326; WBGene00011526; WP:CE02326 YER141W T06E4.7 T06E4.7 T06E4.7; 5K107; CE37849; WBGene00011534; WP:CE37849 T06E6.1 T06E6.1 T06E6.1; 5P874; CE13313; WBGene00011538; WP:CE13313 T06E6.10 T06E6.10 T06E6.10; 5P897; CE13331; O45764_CAEEL; WBGene00011540; WP:CE13331 T06E6.3 T06E6.3 fbxa-199; srx-40; T06E6.3; 5P878; CE40779; NM_074426; WBGene00005931; WP:CE40779 srx-40 encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins; this gene's encoded protein also contains an FTH/DUF38 motif, which may also mediate protein-protein interaction. 7 transmembrane receptor (rhodopsin family) T06E6.5 T06E6.5 fbxa-135; T06E6.5; 5P883; CE39277; WBGene00011539; WP:CE39277 This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins; this gene's encoded protein also contains an FTH/DUF38 motif, which may also mediate protein-protein interaction. T07A9.11 T07A9.11 rps-24; T07A9.11; 4B139; CE40119; NM_067514; WBGene00004493; WP:CE40119 rps-24 encodes a small ribosomal subunit S24 protein; by homology, RPS-24 is predicted to function in protein biosynthesis; in C. elegans, RPS-24 activity is required for germline development and the overall health of the animal. ribosomal protein T07A9.8 T07A9.8 T07A9.8; 4B151; CE17217; WBGene00020296; WP:CE17217 T07C4.1 T07C4.1 T07C4.1; 3L446; CE00638; Q18516_CAEEL; WBGene00011559; WP:CE00638 T07C4.1 is orthologous to the human gene URIDINE MONOPHOSPHATE SYNTHETASE (OROTATE PHOSPHORIBOSYL TRANSFERASE AND OROTIDINE-5'-DECARBOXYLASE) (UMPS; OMIM:258900), which when mutated leads to disease. UMP synthase T07D10.4 T07D10.4 clec-15; T07D10.4; 1N224; WBGene00011584 C-type lectin T07D10.5 T07D10.5 clec-16; T07D10.5; 1N220; WBGene00011585 T07D3.9 T07D3.9 T07D3.9; 2B188; CE32064; CE33447; WBGene00020311; WP:CE32064; WP:CE33447 T07G12.3 T07G12.3 T07G12.3; 4L297; CE13391; WBGene00011594; WP:CE13391 T07G12.5 T07G12.5 T07G12.5; 4L306; CE13395; WBGene00011596; WP:CE13395 permease T07H3.3 T07H3.3 math-38; T07H3.3; 2B864; CE19564; CE36015; WBGene00020326; WP:CE19564; WP:CE36015 T07H3.4 T07H3.4 clec-21; T07H3.4; 2B866; CE38632; WBGene00020327; WP:CE38632 7TM chemoreceptor, clec family T08B1.1 T08B1.1 T08B1.1; 5C464; CE23957; WBGene00020340; WP:CE23957 sugar transporter T08B2.10 T08B2.10 rps-17; T08B2.10; 1G796; CE26948; NM_059394; WBGene00004486; WP:CE26948 rps-17 encodes a small ribosomal subunit S17 protein. 40S ribosomal protein S17 T08E11.1 T08E11.1 T08E11.1; 2C119; CE30167; WBGene00020357; WP:CE30167 This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins; this gene's encoded protein also contains an FTH/DUF38 motif, which may also mediate protein-protein interaction. T08G5.10 T08G5.10 met-II; mtl-2; T08G5.10; 5O498; CE25109; NM_074081; WBGene00003474; WP:CE25109 mtl-2 encodes a metallothionein, a small, cysteine-rich, metal-binding protein; MTL-2 functions in metal detoxification and homeostasis and stress adaptation; MTL-2 expression is induced in larval and adult intestinal cells following exposure to cadmium or heat stress; MTL-2 intestinal expression is dependent upon ELT-2, an intestine-specific GATA-type transcription factor. T08G5.3 T08G5.3 T08G5.3; 5O506; CE40121; WBGene00011624; WP:CE40121 T09A12.2 T09A12.2 T09A12.2; 4I987; CE17231; CE31060; WBGene00020373; WP:CE17231; WP:CE31060 glutathione peroxidase T09A5.2 T09A5.2 klp-3; T09A5.2; 2I131; CE01083; CE36407; CE36408; KLP3_CAEEL; WBGene00002216; WP:CE01083; WP:CE36407; WP:CE36408 klp-3 encodes a C-terminal kinesin motor protein orthologous to Drosophila NCD and Saccharomyces cerevisiae KAR3; expression of antisense klp-3 RNA under the control of a heat shock promoter suggests that KLP-3 plays a role in chromosome movement and segregation that is essential for germline and embryonic development; klp-3 mRNA is expressed at a low level in mixed-stage RNA preparations; consistent with this, a klp-3::lacZ fusion is expressed in newly hatched larvae in the specialized epithelial marginal cells in the pharynx and muscle cells in the posterior gut region. T09B4.8 T09B4.8 T09B4.8; 1G742; CE33176; WBGene00020382; WP:CE33176 aminotransferase T09E11.11 T09E11.11 T09E11.11; 1M935; CE13517; WBGene00011660; WP:CE13517 T09F3.2 T09F3.2 T09F3.2; 2K683; CE02342; WBGene00011662; WP:CE02342 carrier protein C2 T09F5.1 T09F5.1 T09F5.1; 5P629; CE13521; WBGene00011665; WP:CE13521 T10B10.1 T10B10.1 col-41; T10B10.1; CE06399; NM_078121; WBGene00000618; WP:CE06399; XP794 collagen T10B10.2 T10B10.2 ucr-2.2; T10B10.2; CE23962; WBGene00011679; WP:CE23962; XP795 ubiquinol-cytochrome c reductase complex core protein 2 T10B11.1 T10B11.1 pcbd-1; T10B11.1; 1H529; CE39768; WBGene00020397; WP:CE39768 T10B11.1 is orthologous to the human gene PTERIN-4-ALPHA-CARBINOLAMINE DEHYDRATASE (PCBD or TCF1; OMIM:126090), which when mutated leads to hyperphenylalaninemia with primapterinuria. T10B5.3 T10B5.3 T10B5.3; 5C344; CE30832; WBGene00020389; WP:CE30832 T10B9.1 T10B9.1 ccp-13A4; cyp-13A4; dod-1; T10B9.1; 2K84; CE01654; NM_063710; WBGene00011671; WP:CE01654 cytochrome P450 T10B9.10 T10B9.10 ccp-13A7; cyp-13A7; T10B9.10; 2K91; CE01655; NM_063713; WBGene00000372; WP:CE01655 ccp-13A7 encodes a homolog of cytochrome P450 proteins; these proteins are membrane proteins with a heme prosthetic group that catalyse the synthesis of steroid hormones (and bile salts), and also detoxify foreign substances (xenobiotic compounds). cytochrome P450 T10B9.2 T10B9.2 cyp-13A5; T10B9.2; 2K86; CE01656; NM_063711; WBGene00011672; WP:CE01656 cytochrome P450 T10B9.3 T10B9.3 cyp-13A6; T10B9.3; 2K88; CE01657; NM_063712; WBGene00011673; WP:CE01657 cytochrome P450 T10B9.7 T10B9.7 cyp-13A2; T10B9.7; 2K74; CE01659; NM_063708; WBGene00011676; WP:CE01659 cytochrome P450 T11A5.3 T11A5.3 srab-18; T11A5.3; 5K350; CE34092; NM_073144; WBGene00011702; WP:CE34092 T11F9.11 T11F9.11 dhs-19; T11F9.11; 5L970; CE06423; NM_073514; WBGene00000982; WP:CE06423 dhs-19 encodes a short-chain dehydrogenase predicted to be mitochondrial. 3-OXOACYL-[ACYL-CARRIER PROTEIN] REDUCTASE T11F9.4 T11F9.4 aat-6; T11F9.4; 5L944; CE31995; NM_073504; WBGene00000007; WP:CE31995 aat-6 encodes a predicted amino acid transporter catalytic subunit; unlike catalytic subunits in other organisms, however, AAT-6 does not contain the highly conserved cysteine residue known to facilitate covalent interaction with a glycoprotein subunit, suggesting that AAT-6 does not require this residue for heterodimer formation or alternatively, does not require the glycoprotein subunit for function. amino acid permease like T11F9.9 T11F9.9 col-157; T11F9.9; 5L963; CE06421; NM_073512; WBGene00000730; WP:CE06421 collagen T12B5.10 T12B5.10 fbxa-60; T12B5.10; 3B560; CE20067; WBGene00020456; WP:CE20067 This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins; this gene's encoded protein also contains an FTH/DUF38 motif, which may also mediate protein-protein interaction. T12B5.12 T12B5.12 fbxa-70; T12B5.12; 3B576; WBGene00020458 T13A10.10 T13A10.10 aat-4; T13A10.10; 4H38; CE35008; WBGene00000005; WP:CE35008 aat-4 encodes a predicted amino acid transporter catalytic subunit; unlike catalytic subunits in other organisms, however, AAT-4 does not contain the highly conserved cysteine residue known to facilitate covalent interaction with a glycoprotein subunit, suggesting that AAT-4 does not require this residue for heterodimer formation or, alternatively, does not require the glycoprotein subunit for function. T13A10.11 T13A10.11 tag-32; T13A10.11; 4H42; CE30175; CE31726; WBGene00006416; WBGene00020470; WP:CE30175; WP:CE31726 S-adenosylmethionine synthetase T13C2.3 T13C2.3 T13C2.3; 2H81; CE33451; CE39406; WBGene00020479; WP:CE33451; WP:CE39406 T13C5.3 T13C5.3 T13C5.3; CE35768; WBGene00020484; WP:CE35768; XG797 T13C5.5 T13C5.5 bca-1; T13C5.5; CE04946; CE30453; NM_171700; NM_171701; WBGene00000245; WP:CE04946; WP:CE30453; XG820 bca-1 encodes a member of the carbonic anhydrase family. T13F2.4 T13F2.4 T13F2.4; 4K553; CE13625; WBGene00011744; WP:CE13625 T13F3.5 T13F3.5 fbxa-2; T13F3.5; 5Q748; CE39279; WBGene00011752; WP:CE39279 This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins; this gene's encoded protein also contains an FTH/DUF38 motif, which may also mediate protein-protein interaction. F-box domain. T14B1.1 T14B1.1 T14B1.1; CE01662; WBGene00011763; WP:CE01662; XK284 T14B4.9 T14B4.9 T14B4.9; 2H20; CE38979; WBGene00020503; WP:CE38979 T14F9.4 T14F9.4 peb-1; T14F9.4; CE07500; CE34372; Q22491_CAEEL; WBGene00003968; WP:CE07500; WP:CE34372; XC837 T15B7.17 T15B7.17 T15B7.17; 5H295; CE35771; WBGene00020529; WP:CE35771 T16G12.3 T16G12.3 T16G12.3; 3L143; CE34094; WBGene00011804; WP:CE34094 T18H9.1 T18H9.1 grd-6; T18H9.1; 5J705; CE35772; NM_072988; WBGene00001695; WP:CE35772 grd-6 encodes a hedgehog-like protein, with an N-terminal signal sequence, a central low-complexity proline-rich domain, and a C-terminal Ground domain; GRD-6 is expressed in hypodermis and in various neurons, in both head and tail, and the PVT interneuron; the Ground domain is predicted to form a cysteine-crosslinked protein involved in intercellular signalling, and it has subtle similarity to the N-terminal Hedge domain of HEDGEHOG proteins; GRD-6 has no obvious function in RNAi assays. T19A6.2 T19A6.2 ngp-1; T19A6.2; 1I973; CE32493; CE32494; CE38417; NM_059874; NM_059875; WBGene00003596; WP:CE32493; WP:CE32494; WP:CE38417 AUTOANTIGEN NGP-1 T19C3.3 T19C3.3 T19C3.3; 3B228; CE30183; WBGene00020561; WP:CE30183 T19C9.8 T19C9.8 T19C9.8; 5R721; CE16425; WBGene00011844; WP:CE16425 T19D12.1 T19D12.1 T19D12.1; 2G963; CE28677; WBGene00020576; WP:CE28677 A. faecalis PHB depolymerase; zinc finger protein 40 T19D7.1 T19D7.1 T19D7.1; CE07517; WBGene00020569; WP:CE07517; XB293 T19H12.2 T19H12.2 T19H12.2; 5F369; CE13754; WBGene00020588; WP:CE13754 T20B12.1 T20B12.1 T20B12.1; 3I479; CE01407; WBGene00020600; WP:CE01407 T20B12.3 T20B12.3 T20B12.3; 3I473; CE01409; WBGene00020601; WP:CE01409 T20F7.6 T20F7.6 T20F7.6; CE29350; WBGene00020633; WP:CE29350; XR480 AMP-activated protein kinase T21C9.9 T21C9.10 T21C9.9; 5L72; CE35020; WBGene00011895; WP:CE35020 T21C9.12 T21C9.12 scpl-4; T21C9.12; 5L81; CE06481; WBGene00011897; WP:CE06481 REV protein (anti-repression transactivator protein) T21D9.1 T21D9.1 col-164; T21D9.1; CE04989; NM_075985; WBGene00000737; WP:CE04989; XC713 procollagen alpha T21E8.1 T21E8.1 pgp-6; T21E8.1; CE40818; CE40819; NM_077412; WBGene00004000; WP:CE40818; WP:CE40819; XL490 pgp-6 encodes an ATP-binding protein that is a member of the P-glycoprotein subclass of the ATP-binding cassette (ABC) transporter superfamily; PGP-6 is predicted to function as a transmembrane protein that couples energy to transport of various molecules across membranes, but as loss of pgp-6 activity via RNAi results in no obvious defects, the precise role of PGP-6 in C. elegans development and/or behavior is not yet known; pgp-6 promoter-gfp fusion proteins are expressed larvae and adults in the amphids, pharynx, intestine, and other unidentified cells in the head. T21E8.2 T21E8.2 pgp-7; T21E8.2; CE36668; NM_077411; WBGene00004001; WP:CE36668; XL484 pgp-7 encodes an ATP-binding protein that is a member of the P-glycoprotein subclass of the ATP-binding cassette (ABC) transporter superfamily; PGP-7 is predicted to function as a transmembrane protein that couples energy to transport of various molecules across membranes, but as loss of pgp-7 activity via RNAi results in no obvious defects, the precise role of PGP-7 in C. elegans development and/or behavior is not yet known; pgp-7 promoter-gfp fusion proteins are expressed in the rays of the adult male tail. p-glycoprotein T21G5.3 T21G5.3 glh-1; rhl-2; T21G5.3; 1H433; CE25121; NM_059562; WBGene00001598; WP:CE25121 glh-1 encodes a putative DEAD-box RNA helicase that contains four CCHC zinc fingers and is homologous to Drosophila VASA, a germ-line-specific, ATP-dependent RNA helicase; at permissive temperature, GLH-1 is required redundantly with GLH-4 for proper germ-line development and fertility, specifically for regulating the normal extent of germ-line proliferation, oogenesis, and the production of functional sperm; GLH-1 activity is also likely required for the wild-type morphology of P granules and for localization of several protein components, such as PGL-1, but not for accumulation of P granule mRNAs; GLH-1 interacts in vivo with CSN-5, a COP9 signalosome component, and in vitro with itself and with KGB-1, a JNK-like MAP kinase, ZYX-1, a LIM domain-containing zyxin homologue, and GLH-3; GLH-1 is a constitutive P granule component and thus, with the exception of mature sperm, is expressed in germ cells at all stages of development; consistent with its P granule localization, GLH-1 is cytoplasmic in oocytes and the early embryo, while perinuclear in all later developmental stages as well as in the distal and medial regions of the hermaphrodite gonad; GLH-1 is also expressed in males. RNA helicase T21H3.2 T21H3.2 ptr-16; T21H3.2; 5B651; CE13900; NM_070987; WBGene00004230; WP:CE13900 ptr-16 encodes a nematode-specific member of the sterol sensing domain (SSD) proteins, distantly paralogous to Drosophila PATCHED (PTC) and human PTCH (OMIM:601309, mutated in basal cell nevus syndrome); PTR-16 is partially required for normal molting from L2 to L3 larval stages; however, PTR-16 and PTR-1 together are strongly required for both molting and viability, with double ptr-1/-16 RNAi animals showing pronounced molting defects and lethality; PTR-16 is also required for normal growth to full size and locomotion. T22B11.2 T22B11.2 T22B11.2; 4F453; CE17241; WBGene00020676; WP:CE17241 T22B3.1 T22B3.1 dpy-20; T22B3.1; 4M462; CE40520; NM_069814; WBGene00001079; WP:CE40520 dpy-20 encodes a BED zinc finger protein, with no known homologs outside of nematodes, that is required for normal body morphology. DPY-20 protein T22D1.11 T22D1.11 T22D1.11; 4H692; CE17255; WBGene00020688; WP:CE17255 carboxyesterase T22D1.3 T22D1.3 T22D1.3; 4H681; CE30188; CE33940; WBGene00020682; WP:CE30188; WP:CE33940 inosine monophosphate dehydrogenase T22E5.5 T22E5.5 mup-2; tnt-1; T22E5.5; CE04994; NM_076675; WBGene00003495; WP:CE04994; XH28 mup-2 encodes the muscle contractile protein troponin T ( TnT ) homologous to vertebrate and invertebrate TnT and contains an invertebrate- specific COOH -terminal tail; mup-2 affects embryonic body wall muscle cell contraction, sarcomere organization, cell positioning, regulated muscle contraction in larval and adult body wall muscle, epidermal morphogenesis, and is required for proper function of the hermaphrodite nonstriated oviduct myoepithelial sheath, proper growth, and fertility. troponin T-like protein T22F3.4 T22F3.4 rpl-11.1; nog-1; T22F3.4; 5E64; CE13968; NM_071607; WBGene00004422; WP:CE13968 rpl-11.1 encodes a large ribosomal subunit L11 protein. 60S ribososmal protein L11 T22F7.4 T22F7.4 T22F7.4; 3B142; CE39778; WBGene00020703; WP:CE39778 transposase T22G5.2 T22G5.2 lbp-7; T22G5.2; 5O359; CE13984; FABP7_CAEEL; NM_074039; WBGene00002259; WP:CE13984 lbp-7 encodes a predicted intracellular fatty acid binding protein (iFABP) that is most similar to the vertebrate muscle and heart FABPs; by homology, LBP-7 is predicted to function as an intracellular transporter for small hydrophobic molecules such as lipids and steroid hormones; as loss of lbp-7 activity via large-scale RNAi screens does not result in any obvious abnormalities, the precise role of LBP-7 in C. elegans development and/or behavior is not yet known. fatty-acid binding protein T23B12.2 T23B12.2 T23B12.2; 5I949; CE14028; O17005_CAEEL; WBGene00020717; WP:CE14028 ribosomal protein T23B3.2 T23B3.2 T23B3.2; 1H293; CE14010; WBGene00020710; WP:CE14010 T23E1.1 T23E1.1 T23E1.1; 4D917; CE39283; WBGene00020728; WP:CE39283 T23F1.5 T23F1.5 T23F1.5; 5P940; CE14078; WBGene00011948; WP:CE14078 T23F2.1 T23F2.1 phi-42; tag-249; T23F2.1; CE28488; WBGene00020734; WP:CE28488; XG113 glycosyltransferase T23F6.4 T23F6.4 rbd-1; T23F6.4; 4N493; CE18963; NM_070031; WBGene00004315; WP:CE18963 RNA recognition motif. (aka RRM, RBD, or RNP domain) (6 domains) T24A11.3 T24A11.3 nas-26; toh-1; T24A11.3; 3E896; CE35909; NM_065368; WBGene00006591; WP:CE35909 toh-1 encodes an astacin-like metalloprotease; TOH-1 is predicted to function as a secreted protease; experiments that specifically assessed toh-1's role in molting indicate that toh-1(RNAi) causes no abnormal phenotypes. zinc metalloprotease T24A6.8 T24A6.8 nhr-221; T24A6.8; 5E8; CE19590; WBGene00020748; WP:CE19590 zinc finger protein T24C4.1 T24C4.1 ucr-2.3; T24C4.1; 3B499; CE19592; WBGene00020757; WP:CE19592 T24C4.1 encodes an ubiquinol-cytochrome C reductase complex core protein 2 ortholog, predicted by Eisenberg and coworkers to be mitochondrial, and required for germline maintenance in mass RNAi assays. Ubiquinol-cytochrome C reductase complex core protein 2 T25B6.2 T25B6.2 T25B6.2; CE14174; WBGene00020788; WP:CE14174; XJ655 T25B6.2 encodes two isoforms of a neprilysin; neprilysins are thermolysin-like zinc metallopeptidases, found on the outer surface of animal cells, that negatively regulate small signalling peptides (e.g., enkephalin, tachykinin, insulin, and natriuretic peptides) by cleaving them; T25B6.2 is orthologous to Ac-mep-1, a gut luminal neprilysin which is specifically expressed in the adult life stage of Ancylostoma caninum hookworms, and whose protein product is localized to the microvilli of the gastrointestinal tract, suggesting a role in digestion. zinc metalloprotease T25C12.3 T25C12.3 T25C12.3; CE40820; WBGene00012018; WP:CE40820; XM108 EGF-repeats T25F10.2 T25F10.2 cet-1; dbl-1; T25F10.2; 5H239; CE26386; NM_072308; WBGene00000936; WP:CE26386 dbl-1 encodes a member of the transforming growth factor beta (TGFbeta) superfamily that includes Drosophila decapentaplegic (Dpp) and the vertebrate bone morphogenetic proteins (BMPs); DBL-1 functions as a dose-dependent ligand for the SMA-6 and DAF-4 TGFbeta receptors that ultimately activate the SMA-2, -3, and -4 complex of transcription factors to regulate body length and size, as well as the patterning of male sensory rays and copulatory spicules; DBL-1 signaling upregulates sma-6 expression, suggesting that there is positive autoregulation in the DBL-1 signaling pathway; in contrast, DBL-1 negatively regulates expression of LON-1, a predicted secreted protein that is a downstream component of the body size pathway; DBL-1 is expressed primarily in neurons. TGF-beta-like growth factor T26C5.2 T26C5.2 T26C5.2; 2J525; CE35032; WBGene00012032; WP:CE35032 T26E4.4 T26E4.4 T26E4.4; 5Q270; CE16476; WBGene00012046; WP:CE16476 T26F2.2 T26F2.2 T26F2.2; 5O462; CE41027; WBGene00012058; WP:CE41027 T27A1.5 T27A1.5 T27A1.5; 2A815; CE14213; CE39784; WBGene00020837; WP:CE14213; WP:CE39784 T27C5.12 T27C5.7 T27C5.12; 5R891; CE37930; WBGene00044059; WP:CE37930 T27E7.6 T27E7.6 T27E7.6; 4P298; CE16509; WBGene00012091; WP:CE16509 T27E9.7 T27E9.7 T27E9.7; 3O548; CE18971; WBGene00012097; WP:CE18971 ABC transporters (2 domains) T27F6.2 T27F6.2 clec-12; T27F6.2; 1N64; CE16512; WBGene00012103; WP:CE16512 CUB domain, Lectin C-type domain short and long forms (2 domains) T28A11.13 T28A11.13 T28A11.13; 5D726; CE14303; WBGene00020875; WP:CE14303 T28A11.19 T28A11.19 T28A11.19; 5D744; CE14315; WBGene00020881; WP:CE14315 T28A11.4 T28A11.4 T28A11.4; 5D747; CE14287; WBGene00020871; WP:CE14287 T28C6.4 T28C6.4 T28C6.4; 4J588; NM_069125; WBGene00000691 cuticle collagen T28D9.3 T28D9.3 T28D9.3; 2G777; CE02068; CE37155; CE37156; WBGene00020895; WP:CE02068; WP:CE37155; WP:CE37156 T28H10.3 T28H10.3 T28H10.3; 5M993; CE14367; WBGene00012144; WP:CE14367 vacuolar processing enzyme like VW02B12L.1 C05D12.6, VW02B12L.1 vha-6; VW02B12L.1; 2L726; CE18980; NM_064035; WBGene00006915; WP:CE18980 vha-6 encodes an ortholog of subunit a of the membrane-bound (V0) domain of vacuolar proton-translocating ATPase (V-ATPase); VHA-6 is orthologous to human ATP6N1A (OMIM:192130), ATP6V0A2, ATP6V0A4 (OMIM:605239, mutated in distal renal tubular acidosis), and TCIRG1 (OMIM:604592, mutated in osteopetrosis); VHA-6 is expressed in germline (P2 through Z3 cells until the comma stage), on the apical surface of postembryonic intestinal cells, and at the junction between pharynx and intestine; VHA-6 is required for growth and survival past the L1 larval stage; vha-6(RNAi) animals arrest as L1 larvae and remain alive (but do not grow) for one week; in S. cerevisiae, different V0 a-subunits (Stv1p and Vph1p) direct the assembly of V-ATPases to different membranes and organelles, suggesting that the profusion of such subunits in C. elegans (co-orthologous VHA-5, VHA-6, VHA-7, and six UNC-32 isoforms) may have a similar function; VHA-6 is predicted to capture protons from V-ATPase transmembrane rotor components and export the protons across the membrane. vacuolar ATP synthase W01A8.1 W01A8.1 mdt-28; W01A8.1; 1H635; CE06531; CE18303; WBGene00007024; WP:CE06531; WP:CE18303 W01B11.3 W01B11.3 W01B11.3; 1D835; CE18307; WBGene00020915; WP:CE18307 W01C9.2 W01C9.2 W01C9.2; 2I829; CE02368; WBGene00012176; WP:CE02368 W01D2.1 W01D2.1 W01D2.1; 2P101; CE18312; WBGene00012179; WP:CE18312 ribosomal protein L37 W02B12.2 W02B12.2 rsp-2; srp-4; W02B12.2; 2L742; CE03762; CeSRp40; NM_064040; RSP2_CAEEL; WBGene00004699; WP:CE03762 pre-mRNA splicing factor like protein W02C12.1 W02C12.1 W02C12.1; 4E777; CE14412; WBGene00020928; WP:CE14412 EGF-like protein W02D7.5 W02D7.5 W02D7.5; 5I776; CE35793; WBGene00020941; WP:CE35793 W02F12.2 W02F12.2 W02F12.2; 5H174; CE33333; WBGene00020947; WP:CE33333 W03D2.6 W03D2.6 W03D2.6; 4E822; CE33718; WBGene00020981; WP:CE33718 W03D2.9 W03D2.9 W03D2.9; 4E836; CE14522; WBGene00020983; WP:CE14522 W03G1.7 W03G1.7 asm-3; W03G1.7; 4B274; ASM3_CAEEL; CE31626; CE39794; NM_067539; WBGene00000213; WP:CE31626; WP:CE39794 sphingomyelin phosphodiesterase W04A8.2 W04A8.2 W04A8.2; 1O433; CE40144; WBGene00012237; WP:CE40144 W04C9.1 W04C9.1 haf-4; W04C9.1; 1A969; CE28355; NM_058338; WBGene00001814; WP:CE28355 haf-4 encodes a member of the ABC transporter family. ABC transporter W04C9.4 W04C9.4 W04C9.4; 1A935; CE18335; WBGene00021026; WP:CE18335 W05B2.1 W05B2.1 col-94; W05B2.1; 3M76; CE20144; NM_067009; WBGene00000669; WP:CE20144 W05B2.5 W05B2.5 col-93; W05B2.5; 3M74; CE20147; NM_067008; WBGene00000668; WP:CE20147 W05B2.6 W05B2.6 col-92; W05B2.6; 3M72; CE20148; NM_067007; WBGene00000667; WP:CE20148 W06A7.5 W06A7.5 nspa-8; W06A7.5; 5P306; CE14672; NM_074253; WBGene00012294; WP:CE14672 W06B11.2 W06B11.2 puf-9; W06B11.2; CE31253; NM_076579; WBGene00004245; WP:CE31253; XG463 The puf-9 gene encodes a predicted RNA binding protein orthologous to Drosophila PUMILIO and human PUMILIO 2 (OMIM:607205); PUF-9 is required for normal locomotion and fluid balance, and is expressed primarily in somatic tissues; PUF-9 contains a glutamine/asparagine-rich domain. pumilo repeats W06B3.2 W06B3.2 sma-5; W06B3.2; CE31629; CE31630; CE38984; CE39526; NM_171782; NM_171783; WBGene00004859; WP:CE31629; WP:CE31630; WP:CE38984; WP:CE39526; XM616 sma-5 encodes a serine/threonine kinase homologous to the mammalian MAP kinase MAPK7/ERK5 (OMIM:602521, required for development of extraembryonic vasculature and embryonic cardiovasculature); SMA-5 is required for normal body size morphogenesis, growth rates, and intestinal granule distribution, and for regulating the size of the intestine, body wall muscle, and hypodermis, as well as the number of intestinal nuclei; SMA-5 is expressed in the intestine and in hypodermal seam cells. W06D12.3 W06D12.3 fat-5; W06D12.3; 5S205; CE16551; NM_075081; WBGene00001397; WP:CE16551 fat-5 encodes a delta-9 fatty acid desaturase that is predicted to be mitochondrial; when expressed heterologously in S. cerevisiae, FAT-5 rescues the fatty acid auxotrophy of the yeast delta-9 desaturase mutant ole1. Fatty acid desaturase W06E11.2 W06E11.2 tag-267; W06E11.2; 3B259; CE01427; WBGene00021062; WBGene00044318; WP:CE01427 W07B8.5 W07B8.5 cpr-5; W07B8.5; 5B612; CE14682; CPR5_CAEEL; NM_070982; WBGene00000785; WP:CE14682 cpr-5 encodes a cysteine protease. thiol protease W07E6.1 W07E6.1 W07E6.1; 2A762; CE28259; WBGene00021073; WP:CE28259 nucleolar protein W07E6.2 W07E6.2 W07E6.2; 2A772; CE17294; WBGene00021074; WP:CE17294 W07G9.1 W07G9.1 W08A12.4 W08A12.4 W08A12.4; 5E153; CE14702; WBGene00021081; WP:CE14702 W08D2.6 W08D2.6 col-123; W08D2.6; 4K587; CE06561; NM_069355; WBGene00000697; WP:CE06561 col-123 is homologous to the human gene A TYPE IV COLLAGEN (COL6A1; OMIM:303631), which when mutated is sometimes associated with diffuse leiomyomatosis. collagen W08E12.7 W08E12.C W08E12.7; 4E61; CE21275; WBGene00021088; WP:CE21275 peptidase W08E12.5 W08E12.G W08E12.5; 4E65; WBGene00021086 W08E12.3 W08E12.I W08E12.3; 4E69; CE21278; WBGene00021084; WP:CE21278 W08E12.2 W08E12.J W08E12.2; 4E71; CE21279; WBGene00021083; WP:CE21279 W08G11.1 W08G11.1 W08G11.1; 5Q829; CE16558; WBGene00012346; WP:CE16558 W09C5.1 W09C5.1 W09C5.1; 1O220; CE20164; WBGene00012351; WP:CE20164 W09C5.4 W09C5.4 ins-33; W09C5.4; 1O228; CE20166; NM_060988; WBGene00002116; WP:CE20166 ins-33 encodes an insulin-like peptide of the insulin superfamily of proteins (OMIM:176730, 147440); INS-33 is one of 38 insulin-like peptides in C. elegans; loss of INS-33 function can result in embryonic lethality, slow growth, and lack of coordination; additionally, INS-33 appears to be a direct downstream target of LIN-14, a nuclear protein and key regulator of the temporal sequence of postembryonic developmental events. W09C5.6 W09C5.6 rpl-31; W09C5.6; 1O244; CE20168; CE20169; NM_060990; NM_060991; WBGene00004445; WP:CE20168; WP:CE20169 rpl-31 encodes a large ribosomal subunit L31 protein. Ribosomal protein L31e W09D10.3 W09D10.3 W09D10.3; 3L797; CE16564; O18180_CAEEL; WBGene00012361; WP:CE16564 ribosomal protein L7/L12 mitochondrial W09G10.6 W09G10.6 W09G10.6; 2D809; CE24045; WBGene00021118; WP:CE24045 F40G9.1 W10C4.B F40G9.1; 3A811; CE19848; WBGene00018239; WP:CE19848 W10G6.2 W10G6.2 sgk-1; tag-74; W10G6.2; CE39527; CE39528; NM_078246; WBGene00004789; WP:CE39527; WP:CE39528; XQ870 Protein kinase C terminal domain Y105C5A.9 Y105C5A.H Y105C5A.9; 4Q395; CE23190; CE39805; WBGene00013634; WP:CE23190; WP:CE39805 Y105E8A.16 Y105E8C.E rps-20; Y105E8A.16; Y105E8B.S; 1P60; CE29835; NM_170948; WBGene00004489; WP:CE29835 rps-20 encodes a small ribosomal subunit S20 protein. Y106G6D.1 Y106G6D.1 Y106G6D.1; 1K682; CE19299; WBGene00013698; WP:CE19299 Y106G6H.3 Y106G6H.3 rpl-30; Y106G6H.3; 1L13; CE20413; NM_060327; WBGene00004444; WP:CE20413 rpl-30 encodes a large ribosomal subunit L30 protein; by homology, RPL-30 is predicted to function in protein biosynthesis; in C. elegans, loss of rpl-30 function via RNA-mediated interference (RNAi) does not result in any obvious abnormalities. Y110A2AL.8 Y110A2A_54.D ptc-3; Y110A2AL.8; 2D136; CE37163; CE37164; NM_061982; NM_061983; WBGene00004210; WP:CE37163; WP:CE37164 ptc-3 encodes an ortholog of Drosophila PATCHED (PTC) and human PTCH (OMIM:601309, mutated in basal cell nevus syndrome), which defines one of seven paralogous families of sterol sensing domain (SSD) proteins; PTC-3 is strongly required for normal molting from L1 to L3 larval stages; PTC-3 is also required for normal growth to full size and for viability. Y110A7A.19 Y110A7A.A Y110A7A.19; 1F732; CE23238; WBGene00022464; WP:CE23238 Y110A7A.18 Y110A7A.B ppw-2; Y110A7A.18; 1F728; CE23239; NM_059134; WBGene00004094; WP:CE23239 Y110A7A.16 Y110A7A.E Y110A7A.16; 1F682; CE28103; WBGene00022463; WP:CE28103 Y110A7A.16 is orthologous to the human gene INHIBITOR OF KAPPA LIGHT POLYPEPTIDE GENE ENHANCER IN B-CELLS, KINASE COMPLEX-ASSOCIATED PROTEIN (IKBKAP; OMIM:603722), which when mutated leads to disease. Y113G7B.17 Y113G7B.17 Y113G7B.17; 5U738; CE23297; WBGene00013766; WP:CE23297 Y116A8A.5 Y116A8A.5 Y116A8C.43 Y116A8C.43 Y116A8C.43; 4S35; CE28699; WBGene00013814; WP:CE28699 F55C9.3 F55C9.3, Y116F11A.A F55C9.3; 5T762; CE18735; WBGene00010100; WP:CE18735 F55C9.5 F55C9.5, Y116F11A.B F55C9.5; 5T764; CE18737; WBGene00010102; WP:CE18737 Y116F11A.O Y116F11A.O B0399.2 B0399.2, Y116F11A.QQ B0399.2; 5U26; CE36626; WBGene00007177; WP:CE36626 Y43F8C.1 Y116F11A.UU, Y43F8C.1 nlp-25; Y43F8C.1; 5U81; CE21899; NM_075400; Q9XWP3_CAEEL; WBGene00003763; WP:CE21899 Y43F8C.8 Y116F11A.ZZ3, Y43F8C.8 Y43F8C.8; 5U119; CE21906; WBGene00012830; WP:CE21906 Y119D3_446.A Y119D3_446.A Y71D11A.1 Y119D3_451.A cdh-12; Y71D11A.1; Y92C3A.1; 3C269; CE38125; NM_064939; WBGene00022103; WP:CE38125 cdh-12 encodes a cadherin; by sequence similarity, CDH-12 is predicted to function in cellular adhesion, but as loss of cdh-12 activity via large-scale RNAi screens results in no obvious defects, the precise role of cdh-12 in C. elegans development and/or behavior is not yet known. Y119D3_465.G Y119D3_465.G Y82E9BL.17 Y119D3_465.X fbxa-27; Y82E9BL.17; 3C433; CE39195; WBGene00022333; WP:CE39195 Y11D7A.6 Y11D7A.6 Y13C8A.2 Y13C8A.E Y13C8A.2; CE21363; WBGene00021189; WP:CE21363; XR499 Y17G9A.2 Y17G9A.G Y17G9A.2; 4F620; CE27467; WBGene00021195; WP:CE27467 E04A4.8 E04A4.8, Y17G9B.E rpl-20; E04A4.8; 4F516; CE21392; NM_068229; WBGene00004432; WP:CE21392 rpl-20 encodes a large ribosomal subunit L18a protein. ribosomal protein Y17G9B.F Y17G9B.F Y18D10A.23 Y18D10A.23 Y18D10A.23; 1N460; CE21420; WBGene00012487; WP:CE21420 Y19D10A.D Y19D10A.D Y19D10A.H Y19D10A.H Y19D10A.J Y19D10A.J Y24D9A.4 Y24D9A.D phi-22; rpl-7A; rpl-8; Y24D9A.4; 4F154; CE27398; CE30401; NM_171316; NM_171904; WBGene00004419; WP:CE27398; WP:CE30401 rpl-8 encodes a large ribosomal subunit L7a protein required in mass RNAi assays for fertility, vulval development, and general health; the rpl-8 transcription unit has one nonsense transcript that is up-regulated in vivo by smg[-] mutations, indicating that rpl-8 is a natural substrate for SMG-mediated nonsense suppresssion; several other natural mRNA substrates of SMG suppression (e.g., rpl-3, rpl-10, rpl-12) have protein products that are involved in translation. F55F10.1 Y24D9A.E, Y24D9A.F F55F10.1; Y24D9A.F; 4F151; CE30377; WBGene00018898; WP:CE30377 F55F10.1 Y24D9A.E, Y24D9A.F F55F10.1; Y24D9A.F; 4F151; CE30377; WBGene00018898; WP:CE30377 Y27F2A.6 Y27F2A.C Y27F2A.6; 2D464; CE21493; WBGene00021298; WP:CE21493 Y2H9A.4 Y2H9A.4 Y2H9A.4; 5N927; CE40243; WBGene00012381; WP:CE40243 Y38C1AB. Y38C1AB. Y38C1AB.F Y38C1AB.F Y38C1AB.K Y38C1AB.K Y38C9B.1 Y38C9B.C cyp-29A3; Y38C9B.1; Y38C9B.C; 5A539; CE35365; NM_070729; WBGene00021412; WP:CE35365 cytochrome P450 Y38E10A.11 Y38E10A.K Y38E10A.11; 2M905; CE21591; WBGene00012589; WP:CE21591 Y38E10A.13 Y38E10A.M Y38E10A.13; 2M910; CE21593; WBGene00012591; WP:CE21593 Y38F1A.3 Y38F1A.3 ptr-18; Y38F1A.3; 2N267; CE36233; NM_064360; WBGene00004232; WP:CE36233 ptr-18 encodes a nematode-specific member of the sterol sensing domain (SSD) proteins, distantly paralogous to Drosophila PATCHED (PTC) and human PTCH (OMIM:601309, mutated in basal cell nevus syndrome); PTR-18 is strongly required for normal molting from L3 to adult stage (a role conserved in C. briggsae); PTR-18 is also required for male tail development and vulval morphogenesis, and (partly) for endocytosis of yolk by oocytes. Y38F2AR.10 Y38F2A_6126.C Y38F2AR.10; 4D162; CE29375; WBGene00021428; WP:CE29375 Y38F2A_9208.A Y38F2A_9208.A Y39A1A.18 Y39A1A.18 Y39A1A.18; 3L776; CE19138; WBGene00012656; WP:CE19138 Y39A3CL.1 Y39A3C_78.A Y39A3CL.1; 3C935; CE32963; WBGene00021440; WP:CE32963 Y39B6A.33 Y39B6B.O Y39B6A.33; 5T479; CE21690; WBGene00012692; WP:CE21690 Y39C12A.1 Y39C12A.A Y39C12A.1; 4M988; CE25264; WBGene00012704; WP:CE25264 Y39C12A.D Y39C12A.D Y39C12A.8 Y39C12A.G dnj-26; Y39C12A.8; 4N16; CE24236; NM_069925; WBGene00001044; WP:CE24236 This gene encodes a protein containing a DnaJ ('J') domain. Y39E4A.3 Y39E4A.3 Y39E4A.3; 3O58; CE33866; CE38987; O45924_CAEEL; WBGene00012713; WP:CE33866; WP:CE38987 Y39E4A.3 is orthologous to the human gene MAPLE SYRUP URINE DISEASE, TYPE IA (MSUD, TYPE IA; E1-alpha subunit of branched-chain keto acid dehydrogenase; OMIM:248600), which when mutated leads to maple syrup urine disease; Y39E4A.3 protein is predicted to be mitochondrial. Y41D4B.5 Y41D4A_3613.A rps-28; Y41D4B.5; 4C425; CE21842; NM_067714; WBGene00004497; WP:CE21842 rps-28 encodes a small ribosomal subunit S28 protein. Y41D4B.17 Y41D4B_7946.B Y41D4B.17; 4C325; CE21858; WBGene00021519; WP:CE21858 Y41E3.10 Y41E3.10 Y41E3.10; 4P803; CE37568; CE40788; WBGene00012768; WP:CE37568; WP:CE40788 Elongation factor 1 (beta/delta chain) Y41E3.2 Y41E3.2 col-134; dpy-4; Y41E3.2; 4P750; CE18370; NM_070407; WBGene00001066; WP:CE18370 dpy-4 encodes a cuticle collagen; dpy-4 activity is required for normal body morphology, locomotion, and larval development. CUTICLE COLLAGEN 1 Y43C5A.3 Y43C5A.3 Y43C5A.3; 4L37; CE19152; WBGene00012783; WP:CE19152 Y43F8A.3 Y43F8A.3 Y43F8A.3; 5T853; CE38569; WBGene00012810; WP:CE38569 Y43F8B.9 Y43F8B.9 Y43F8B.9; 5T955; CE21893; WBGene00012819; WP:CE21893 Y43F8C.1 Y116F11A.UU, Y43F8C.1 nlp-25; Y43F8C.1; 5U81; CE21899; NM_075400; Q9XWP3_CAEEL; WBGene00003763; WP:CE21899 Y43F8C.2 Y43F8C.2 nlp-26; Y43F8C.2; 5U89; CE21900; NM_075401; WBGene00003764; WP:CE21900 nlp-26 encodes a predicted neuropeptide not found in multigene families within C. elegans and is not clearly related to other well-characterized neuropeptides. Y43F8C.8 Y116F11A.ZZ3, Y43F8C.8 Y43F8C.8; 5U119; CE21906; WBGene00012830; WP:CE21906 Y44A6B.4 Y44A6B.4 Y44A6B.4; 5V102; CE18387; WBGene00012849; WP:CE18387 Transthyretin-like family Y45F10D.12 Y45F10D.12 rpl-18; Y45F10D.12; 4O543; CE16650; NM_070254; WBGene00004430; WP:CE16650 rpl-18 encodes a large ribosomal subunit L18 protein. Eukaryotic ribosomal protein L18 Y45F10D.7 Y45F10D.7 Y45F10D.7; Y45F10D.8; 4O559; CE39843; WBGene00012887; WP:CE39843 Y46C8_100.A Y46C8_100.A Y46C8AL.8 Y46C8_100.B clec-74; Y46C8AL.8; 4E725; CE39846; WBGene00021585; WP:CE39846 Y46G5A.29 Y46G5.HH Y46G5A.29; 2N151; CE37286; WBGene00012917; WP:CE37286 Y46H3A.H Y46H3A.H Y47D7A.15 Y47D7A_143.A, Y47D7A_143.C Y47D7A.15; Y47D7A.B; 5E911; CE36236; WBGene00021627; WP:CE36236 Y47D7A.13 Y47D7A_143.B Y47D7A.13; 5E914; CE22060; WBGene00021625; WP:CE22060 Y47D7A.15 Y47D7A_143.A, Y47D7A_143.C Y47D7A.15; Y47D7A.B; 5E911; CE36236; WBGene00021627; WP:CE36236 Y47G6A.19 Y47G6A_241.A Y47G6A.19; 1E92; CE31374; CE37065; CE41051; WBGene00021645; WP:CE31374; WP:CE37065; WP:CE41051 carboxypeptidase Y48A6B.3 Y48A6B.3 Y48A6B.3; 3M97; CE19186; NOLA2_CAEEL; WBGene00012964; WP:CE19186 Ribosomal protein L7Ae Y48B6A.1 Y48B6A.1 Y48B6A.1; 2O442; CE22116; WBGene00012978; WP:CE22116 Y48B6A.2 Y48B6A.2 rpl-43; Y48B6A.2; 2O445; CE22117; NM_064556; WBGene00004456; WP:CE22117 rpl-43 encodes a large ribosomal subunit L37a protein. Y48C3A.3 Y48C3A.G Y48C3A.3; 2N599; CE22138; WBGene00012987; WP:CE22138 Y48E1B.8 Y48E1B.8 Y48E1B.8; 2N877; CE14866; WBGene00013007; WP:CE14866 Y48G1A.4 Y48G1A_54.A, Y48G1A_54.D Y48G1A.4; 1A803; CE27000; WBGene00021660; WP:CE27000 Y48G1A.4 Y48G1A_54.A, Y48G1A_54.D Y48G1A.4; 1A803; CE27000; WBGene00021660; WP:CE27000 Y48G8AL.8 Y48G8A_3945.C rpl-17; Y48G8AL.8; Y48G8A_3945.C; 1B631; CE22195; CE30023; NM_170799; NM_171832; WBGene00004429; WP:CE22195; WP:CE30023 rpl-17 encodes a large ribosomal subunit L17 protein; by homology, RPL-17 is predicted to function in protein biosynthesis; in C. elegans, RPL-17 activity is required for embryonic and germline development, as well as normal postembryonic growth rates. Y49A3A.1 Y49A3A.1 Y49A3A.1; Y49A3A.A; 5O835; CE40163; NM_074157; WBGene00013024; WP:CE40163 Y49A3A.1 encodes a homolog of choline/ethanolaminephosphotransferase choline phosphotransferase 1; Y49A3A.1 shares an operon with vha-13, and thus might be a previously undescribed V-ATPase component or ancillary protein. Y49A3A.2 Y49A3A.2 phi-51; vha-13; Y49A3A.2; Y49A3A.B; Y49A3A.C; CE22210; NM_074158; WBGene00013025; WP:CE22210 vha-13 encodes an ortholog of subunit A of the cytoplasmic (V1) domain of vacuolar proton-translocating ATPase (V-ATPase); VHA-13 is predicted to hydrolyse ATP as part of a cytosolic VHA-12/VHA-13 heterohexamer, whose activity drives the V-ATPase rotor; VHA-13 levels are lowered in mutants with either abnormally low or abnormally high calcineurin levels, and elevated in mutants lacking both calcineurin and calreticulin; VHA-13 is dispensable for alae formation, like the V1 subunit VHA-8, but not like the V0 subunits VHA-1 and VHA-4. ATP synthase alpha and beta subunits ; ATP synthase ab C terminal Y49C4A.8 Y49C4A_70.A ugt-29; Y49C4A.8; 5B176; CE26130; CE33344; WBGene00021709; WP:CE26130; WP:CE33344 7TM chemoreceptor, ugt family Y49E10.20 Y49E10.20 Y49E10.20; Y49E10.T; 3N544; CE22235; WBGene00013039; WP:CE22235 Y49E10.20 encodes a ortholog of human CD36 antigen (OMIM:173510, mutated in platelet glycoprotein IV deficiency); Y49E10.20 is needed for cell corpse engulfment in the germline and in the three-fold embryo, and for migration of the anterior arm of the gonad. CD36 family Y49F6B.2 Y49F6B.Q Y49F6B.2; 2D793; CE25336; WBGene00021715; WP:CE25336 Y49F6C.3 Y49F6C.3 bath-9; Y49F6C.3; 2D667; CE22267; Q9TYJ0_CAEEL; WBGene00021725; WP:CE22267 Y49G5A.1 Y49G5A.1 Y49G5A.1; 5F762; CE22273; WBGene00021731; WP:CE22273 trypsin inhibitor Y50E8A.3 Y50E8.C oig-3; Y50E8A.3; 5P207; CE22305; NM_074236; WBGene00003861; WP:CE22305 Y51A2B.1 Y51A2B.1 Y51A2B.1; 5S847; CE16655; WBGene00013065; WP:CE16655 Y51A2D.10 Y51A2D.10 Y51A2D.10; 5T37; CE19206; WBGene00013078; WP:CE19206 Transthyretin-like family Y51B9A.9 Y51B9A.9 Y51B9A.9; 2J686; CE19219; WBGene00013091; WP:CE19219 serine/threonine kinase Y51H7C.7 Y51H7C_255.E Y51H7C.7; 2B693; CE22363; WBGene00021785; WP:CE22363 Y53C10A.2 Y53C10A.2 Y53C10A.2; 1M560; CE40288; WBGene00013133; WP:CE40288 Y53C12B.1 Y53C12B.1 Y53C12B.1; 2K34; CE14894; WBGene00013143; WP:CE14894 WD domain, G-beta repeats (4 domains) Y53C12B.2 Y53C12B.2 Y53C12B.2; 2K30; CE14896; WBGene00013144; WP:CE14896 Y53F4B.25 Y53F4C.F Y53F4B.25; 2P429; CE26158; WBGene00013171; WP:CE26158 H06I04.4 H06I04.A, H06I04.F, Y53G8B_1025.A ubl-1; H06I04.4; 3E159; CE20938; CE31022; NM_171089; UBL1_CAEEL; WBGene00006725; WP:CE20938; WP:CE31022 ubl-1 encodes a protein similar to Drosophila ubiquitin/ ribosomal protein S27a that affects body length, fertility, and larval viability. H06I04.3 H06I04.H, Y53G8B_1025.C H06I04.3; 3E173; CE23795; CE38200; CE38201; WBGene00019168; WP:CE23795; WP:CE38200; WP:CE38201 Y54E10A.15 Y54E10A_156.A cdt-1; Y54E10A.15; 1D792; CE22447; NM_058725; NM_182086; WBGene00000413; WP:CE22447 Y54E2A.11 Y54E2A.11 eif-3.B; Y54E2A.11; 2P83; CE20310; CE35681; WBGene00001225; WP:CE20310; WP:CE35681 F30H5.2 Y55B1A_115.B nlp-32; F30H5.2; Y55B1A_115.B; 3B102; CE01926; NM_064803; WBGene00003770; WP:CE01926 Y55D5A.5 Y55D5A_391.B daf-2; Y55D5A.5; Y55D5A_392.A; 3E86; CE27499; NM_065249; WBGene00000898; WP:CE27499 daf-2 encodes a predicted receptor tyrosine kinase that is the C. elegans insulin/IGF receptor ortholog; DAF-2 activity is required for a number of processes in C. elegans, including embryonic and larval development, formation of the developmentally arrested dauer larval stage, adult longevity, reproduction, fat storage, salt chemotaxis learning, and response to exogenous stressors such as high temperature or bacterial infection; DAF-2 signals through a conserved PI 3-kinase pathway to negatively regulate the activity of DAF-16, a Forkhead-related transcription factor, by inducing its phosphorylation and nuclear exclusion; amongst the 38 predicted insulin-like molecules in C. elegans, genetic and microarray analyses suggest that at least DAF-28, INS-1, and INS-7 are likely DAF-2 ligands; genetic mosaic and tissue-specific promoter studies indicate that daf-2 can function cell nonautonomously and within multiple cell types to influence dauer formation and adult lifespan, likely by regulating the production of secondary signals that coordinate growth and longevity throughout the animal. Y55F3AM.14 Y55F3A_748.A Y55F3AM.14; 4B812; CE22541; WBGene00021931; WP:CE22541 Y57A10A.26 Y57A10A.Z Y57A10A.26; 2M555; CE22631; WBGene00013266; WP:CE22631 Y57A10B.3 Y57A10B.3 Y57A10B.3; 2M675; CE20324; WBGene00013275; WP:CE20324 Y57E12B.3 Y57E12_246.A Y57E12B.3; Y57E12B.B; 5H412; CE26551; WBGene00021963; WP:CE26551 Y57G11B.1 Y57G11B.1 Y57G11B.1; 4P306; CE16665; WBGene00013294; WP:CE16665 Y57G11C.16 Y57G11C.16 rps-18; Y57G11C.16; 4P591; CE14956; NM_070393; WBGene00004487; WP:CE14956 rps-18 encodes a small ribosomal subunit S18 protein. ribosomal protein S13 Y59C2A.1 Y59C2A.1 Y59C2A.1; 2C501; CE31658; WBGene00021984; WP:CE31658 carboxypeptidase Y5F2A.2 Y5F2A.2 Y5F2A.2; 4L830; CE19023; WBGene00012383; WP:CE19023 Transthyretin-like family Y61A9LA.10 Y61A9LA_75.A Y61A9LA.10; 5F86; CE31121; WBGene00022021; WP:CE31121 Y62H9A.13 Y62H9A.13 Y62H9A.13; CE19249; WBGene00013401; WP:CE19249; XM537 Y65B4BR.5 Y65B4B_10.B, Y65B4B_10.D Y65B4BR.5; Y65B4BR.H; 1B9; CE22740; CE33239; NACA_CAEEL; WBGene00022042; WP:CE22740; WP:CE33239 Y65B4BR.5 Y65B4B_10.B, Y65B4B_10.D Y65B4BR.5; Y65B4BR.H; 1B9; CE22740; CE33239; NACA_CAEEL; WBGene00022042; WP:CE22740; WP:CE33239 Y65B4BL.2 Y65B4B_13.B Y65B4BL.2; 1A981; CE25536; WBGene00022034; WP:CE25536 Y66A7A.6 C37G2.6, Y66A7A.6, Y66a7a.6 gly-8; Y66A7A.6; 3M717; CE15691; NM_067103; WBGene00001633; WP:CE15691 gly-8 encodes a predicted transmembrane polypeptide N-acetylgalactosaminyl transferase (ppGaNTase) similar to the essential Drosophila ppGaNTase encoded by Pgant35A; by homology, GLY-8 is predicted to function as a Golgi enzyme that catalyzes transfer of N-acetylgalactosamine to serine and threonine-containing acceptor peptides, thus initiating mucin-type O-glycosylation; as loss of gly-8 activity via large-scale RNAi screens does not result in any obvious abnormalities, the precise role of GLY-8 in C. elegans development and/or behavior is not yet known. Glycosyl transferases Y66A7A.6 C37G2.6, Y66A7A.6, Y66a7a.6 gly-8; Y66A7A.6; 3M717; CE15691; NM_067103; WBGene00001633; WP:CE15691 gly-8 encodes a predicted transmembrane polypeptide N-acetylgalactosaminyl transferase (ppGaNTase) similar to the essential Drosophila ppGaNTase encoded by Pgant35A; by homology, GLY-8 is predicted to function as a Golgi enzyme that catalyzes transfer of N-acetylgalactosamine to serine and threonine-containing acceptor peptides, thus initiating mucin-type O-glycosylation; as loss of gly-8 activity via large-scale RNAi screens does not result in any obvious abnormalities, the precise role of GLY-8 in C. elegans development and/or behavior is not yet known. Glycosyl transferases Y48G9A.10 Y67D8A_376.A cpt-3; Y48G9A.10; Y48G9A.E; 3D177; CE37434; WBGene00021703; WP:CE37434 Y67D8C.8 Y67D8A_380.C cpg-9; Y67D8C.8; 4D834; CE27506; WBGene00022072; WP:CE27506 Y69E1A.5 Y69E1A.5 Y69E1A.5; 4L720; CE22812; WBGene00013477; WP:CE22812 Phosphatidylethanolamine-binding protein Y6E2A.4 Y6E2A.3, Y6E2A.4 Y6E2A.4; 5Q194; CE31125; WBGene00012398; WP:CE31125 Y6E2A.4 Y6E2A.3, Y6E2A.4 Y6E2A.4; 5Q194; CE31125; WBGene00012398; WP:CE31125 Y6E2A.5 Y6E2A.5 Y6E2A.5; 5Q196; CE20186; WBGene00012399; WP:CE20186 Y71F9A_294.C Y71F9A_294.C Y71H10A.2 Y71H10A.2 Y71H10A.2; CE20354; Q9TZL9_CAEEL; WBGene00022200; WP:CE20354; XD555 Y71H2AM.23 Y71H2_378.A EF-Tu1; tufm-1; Y71H2AM.23; Y71H2AM.A; 3D902; CE27322; WBGene00007000; WBGene00022187; WP:CE27322 Y71H2AM.15 Y71H2_390.D Y71H2AM.15; 3D838; CE27319; CE39069; Q9BL41_CAEEL; WBGene00022180; WP:CE27319; WP:CE39069 Y73F4A.3 Y73F4A.3 Y73F4A.3; 4J804; CE20369; WBGene00013516; WP:CE20369 Y75B8A.20 Y75B8A.20 grl-15; Y75B8A.20; Y75B8A.W; 3N322; CE23031; NM_067191; WBGene00001724; WP:CE23031 grl-15 encodes a hedgehog-like protein, with an N-terminal signal sequence, a central proline-rich low-complexity region, and a C-terminal Ground-like (Grl) domain; GRL-15 is expressed in the reproductive system, vulva, and larval hypodermis; the Grl domain is predicted to form a cysteine-crosslinked protein involved in intercellular signalling, and it has subtle similarity to the N-terminal Hedge domain of HEDGEHOG proteins. Y76A2B.3 Y76A2B.3 Y76A2B.3; 3O630; CE19275; WBGene00013575; WP:CE19275 AMP-binding enzyme Y87G2A.5 Y87G2A. vrs-2; Y87G2A.5; 1O140; CE24685; NM_060976; WBGene00006936; WP:CE24685 vrs-2 encodes a predicted cytoplasmic valyl-tRNA synthetase (ValRS), a class I aminoacyl-tRNA synthetase that catalyzes the attachment of valine to its cognate tRNA and is thus required for protein biosynthesis; in C. elegans, VRS-2 activity is required for embryonic and germline development. Y95B8A.1 Y95B8A_85.G nas-30; Y95B8A.1; 1B417; CE36770; NM_058394; WBGene00003548; WP:CE36770 peptidase Y97E10AR.1 Y97E10A_262.A Y97E10AR.1; 5I483; CE33347; WBGene00022396; WP:CE33347 Y9C9A.16 Y9C9A_54.A Y9C9A.16; 4F728; CE39879; WBGene00021183; WP:CE39879 ZC123.1 ZC123.1 ZC123.1; 1B313; CE28152; WBGene00022517; WP:CE28152 ZC155.1 ZC155.1 nex-1; ZC155.1; 3G315; CE01431; NM_065708; Q27864_CAEEL; WBGene00003588; WP:CE01431 nex-1 encodes an annexin, a member of a family of calcium-dependent phospholipid binding proteins; NEX-1 is required for efficient engulfment of apoptotic cell corpses in the pharynx, and may also function in other membrane fusion events, such as exocytosis; NEX-1 in vitro can bind phosphatidylserine, phosphatidylinositol, heparin, heparan sulfate, and chondroitin sulfate; NEX-1 is expressed in the pharynx, hypodermal cells, the vulva, the uterus, the spermathecal valve, and yolk granules of maturing oocytes. ZC168.5 ZC168.5 grl-21; ZC168.5; 4L503; CE06571; NM_069587; WBGene00001730; WP:CE06571 grl-21 encodes a hedgehog-like protein, with an N-terminal signal sequence, a central proline-rich low-complexity region, and a C-terminal Ground-like (Grl) domain; GRL-21 is expressed in arcade cells and hypodermis; the Grl domain is predicted to form a cysteine-crosslinked protein involved in intercellular signalling, and it has subtle similarity to the N-terminal Hedge domain of HEDGEHOG proteins. ZC190.4 ZC190.4 ZC190.4; 5J151; CE31136; WBGene00022538; WP:CE31136 ZC190.5 ZC190.5 ZC190.5; 5J150; CE18428; WBGene00022539; WP:CE18428 ZC196.1 ZC196.1 ZC196.1; 5J217; CE36055; WBGene00022545; WP:CE36055 ZC196.2 ZC196.2 ZC196.2; 5J215; CE15068; WBGene00022546; WP:CE15068 ZC204.11 ZC204.11 ZC204.11; 2B944; CE15104; WBGene00022561; WP:CE15104 ZC239.12 ZC239.12 sdz-35; ZC239.12; 2D498; CE15132; WBGene00022570; WP:CE15132 ZC239.14 ZC239.14 ZC239.14; 2D510; CE29150; WBGene00022572; WP:CE29150 ZC250.3 ZC250.3 ZC250.3; 5G274; CE36059; WBGene00022577; WP:CE36059 ZC410.5 ZC410.5 ZC410.5; 4J855; CE15209; CE35703; WBGene00013882; WP:CE15209; WP:CE35703 microfilarial antigen like ZC412.6 ZC412.6 nspa-5; ZC412.6; 5P359; CE15221; NM_074263; WBGene00013887; WP:CE15221 ZC412.7 ZC412.7 nspa-3; ZC412.7; 5P362; NM_074265; WBGene00013888 ZC434.2 ZC434.2 rps-7; ZC434.2; 1K907; CE06577; NM_060307; WBGene00004476; WP:CE06577 rps-7 encodes a small ribosomal subunit S7 protein. 40S ribosomal protein S7 ZC434.3 ZC434.3 ZC434.3; 1K910; CE06578; WBGene00013891; WP:CE06578 ZC434.9 ZC434.9 ZC434.9; 1K935; CE25665; CE36256; WBGene00013895; WP:CE25665; WP:CE36256 carboxypeptidase ZC443.2 ZC443.2 ZC443.2; 5N290; CE06586; WBGene00013897; WP:CE06586 ZC455.4 ZC455.4 ugt-6; ZC455.4; 5N276; CE24704; WBGene00013904; WP:CE24704 UDP-glucuronysltransferase ZC47.1 ZC47.1 ZC47.1; WBGene00043944 ZC47.4 ZC47.4 fbxa-30; ZC47.4; 3C362; CE15002; WBGene00013837; WP:CE15002 This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins; this gene's encoded protein also contains an FTH/DUF38 motif, which may also mediate protein-protein interaction. ZC487.4 ZC487.4 grl-9; ZC487.4; 5H210; CE07606; NM_072305; WBGene00001718; WP:CE07606 grl-9 encodes a hedgehog-like protein, with an N-terminal signal sequence, a central proline-rich low-complexity region, and a C-terminal Ground-like (Grl) domain; the Grl domain is predicted to form a cysteine-crosslinked protein involved in intercellular signalling, and it has subtle similarity to the N-terminal Hedge domain of HEDGEHOG proteins. ZC8.3 ZC8.3 set-30; tag-226; ZC8.3; CE33744; WBGene00022499; WP:CE33744; XF621 ZK1025.2 ZK1025.2 ZK1025.2; 1M42; CE19329; WBGene00014182; WP:CE19329 ZK1025.4 ZK1025.4 ZK1025.4; 1M48; CE37173; CE40294; WBGene00014184; WP:CE37173; WP:CE40294 ZK1025.5 ZK1025.5 ZK1025.5; 1M46; WBGene00014185 ZK1025.6 ZK1025.6 nhr-244; ZK1025.6; 1M47; CE19333; WBGene00014186; WP:CE19333 ZK1025.7 ZK1025.7 ZK1025.7; 1M59; CE19334; WBGene00014187; WP:CE19334 ZK1025.8 ZK1025.8 ZK1025.8; 1M63; WBGene00014188 ZK105.F ZK105.F ZK1067.6 ZK1067.6 sym-2; ZK1067.6; 2J470; CE35148; NM_063559; WBGene00006367; WBGene00014211; WP:CE35148 sym-2 encodes a predicted RNA binding protein that contains three RNA recognition motifs (RRMs) similar to those of Drosophila Fusilli and mammalian hnRNP F and H; genetic analyses indicate that, during embryonic development, sym-2 functions redundantly with mec-8, which also encodes an RRM-containing protein, to affect the structure of body wall muscles or their attachment to the body cuticle, perhaps by regulating maturation of transcripts essential for muscle development. hnRNP F protein like ZK112.1 ZK112.1 pcp-1; ZK112.1; 3I849; CE25679; NM_066287; WBGene00003956; WP:CE25679 ZK112.3 ZK112.3 ZK112.3; 3I815; CE00374; WBGene00022659; WP:CE00374 ZK1127.5 ZK1127.5 ZK1127.5; 2H339; CE32083; WBGene00022852; WP:CE32083 ZK1240.2 ZK1240.2 ZK1240.2; 2C613; CE33495; O16682_CAEEL; WBGene00022867; WP:CE33495 ZK1251.8 ZK1251.8 twk-21; twk-9; ZK1251.8; 4K459; CE40540; NM_069323; WBGene00006664; WP:CE40540 potassium channel protein ZK1290.12 ZK1290.12 wrt-1; ZK1290.12; 2H823; CE15545; NM_063178; WBGene00006947; WP:CE15545; WRT1_CAEEL warthog gene ZK1307.2 ZK1307.2 ZK1307.2; 2J944; CE01691; WBGene00014245; WP:CE01691 ZK1320.4 ZK1320.4 cyp-13A10; ZK1320.4; 2J952; C13AA_CAEEL; CE37736; NM_063684; WBGene00014254; WP:CE37736 cytochrome P450 ZK1321.4 ZK1321.4 ZK1321.4; 2K62; CE32038; WBGene00014262; WP:CE32038 ZK180.5 ZK180.5 ZK180.5; 4F280; CE07623; CE28179; CE31746; WBGene00022679; WP:CE07623; WP:CE28179; WP:CE31746 ZK180.6 ZK180.6 ZK180.6; 4F284; CE40731; WBGene00022680; WP:CE40731 ZK265.6 ZK265.6 ZK265.6; 1I831; CE15299; WBGene00013958; WP:CE15299 ZK270.1 ZK270.1 ptr-23; ZK270.1; 1P503; CE15305; NM_061202; WBGene00004237; WP:CE15305 ptr-23 encodes a nematode-specific member of the sterol sensing domain (SSD) proteins, distantly paralogous to Drosophila PATCHED (PTC) and human PTCH (OMIM:601309, mutated in basal cell nevus syndrome); PTR-23 is strongly required for normal molting from L4 to adult stages (a role conserved in C. briggsae); PTR-23 is also required for normal male tail development, vulval morphogenesis, adult alae formation, and (partly) for endocytosis of yolk by oocytes. ZK353.4 ZK353.4 ZK353.4; 3J476; CE00388; WBGene00022700; WP:CE00388 ZK354.7 ZK354.7 ZK354.7; 4G68; CE15322; WBGene00022708; WP:CE15322 ZK355.3 ZK355.E ZK355.3; 2D216; CE23458; WBGene00022713; WP:CE23458 ZK381.1 ZK381.1 him-3; ZK381.1; 4H743; CE07625; NM_068677; WBGene00001862; WP:CE07625 him-3 encodes a homolog of the S. cerevisiae HOP1 protein which is required for the formation of the synaptonemal complex during meiosis; him-3 is required for synapsis and chiasma formation during meiotic recombination and for chromosome segregation; him-3 mutants show a high frequency of males in the population as well as a high frequency of arrested embryos due to defects in X-chromosome segregation; HIM-3 localizes to the meiotic chromosome associating with both unsynapsed and synapsed chromosomes. ZK381.2 ZK381.2 ZK381.2; 4H731; CE07626; WBGene00022725; WP:CE07626 ZK381.4 ZK381.4 pgl-1; ZK381.4; 4H740; CE07628; CE25689; NM_068676; PGL1_CAEEL; WBGene00003992; WP:CE07628; WP:CE25689 pgl-1 encodes a predicted RNA-binding protein that contains a number of C-terminal RGG box motifs; PGL-1 activity is required at high temperatures during midlarval to adult stages for postembryonic germline development and hence fertility, and also for proper formation of the germline-specific P granules; PGL-1 protein, supplied maternally and embryonically, is a constitutive P granule component and thus, its localization is cytoplasmic in oocytes and early embryos, while perinuclear in the germline blastomere P4 and proliferating germ cells of larvae and adults; pgl-1 mRNA is expressed exclusively in hermaphrodite and male germlines and is detectable at all stages of development, with highest levels seen in adults; PGL-1 localization to P granules requires wild-type activity of the predicted germline helicase GLH-1. ZK402.1 ZK402.1 ZK402.1; CE05073; WBGene00022728; WP:CE05073; XC23 ZK418.9 ZK418.9 ZK418.9; 3I176; CE28190; CE34457; WBGene00022738; WP:CE28190; WP:CE34457 ZK418.9 encodes two proteins by alternative splicing, belonging to an ancient family of single-stranded nucleic acid-binding proteins, that are predicted to regulate gene expression through binding either mRNA or (locally) single-stranded DNA; they are most likely to specifically bind one or more discrete mRNAs and regulate their spatial localization or alternative splicing. ZK430.7 ZK430.7 ZK430.7; 2E714; CE05083; WBGene00022742; WP:CE05083 ribosomal processing protein ZK430.8 ZK430.8 mlt-7; phi-48; ZK430.8; 2E693; CE05084; WBGene00022743; WP:CE05084 peroxidase ZK455.1 ZK455.1 aco-1; gei-22; ZK455.1; ACOC_CAEEL; CE03812; NM_077497; WBGene00000040; WP:CE03812; XL961 aco-1 encodes an aconitase that is homologous to mammalian iron regulatory protein-1 (IRP1); aco-1 activity is required for normal brood sizes and, under iron stress conditions, for normal lifespan and L4-to-adult growth rates; ACO-1 physically interacts with GEX-3; like IRP1, ACO-1 has aconitase activity and is post-translationally regulated by iron, but, unlike IRP1, it lacks RNA-binding activity; ACO-1 is predicted to be mitochondrial, and its mRNA levels appear to decrease in response to iron treatment. iron-responsive element-binding like protein ZK455.4 ZK455.4 asm-2; ZK455.4; ASM2_CAEEL; CE31674; NM_077493; WBGene00000212; WP:CE31674; XL940 asm-2 encodes a protein similar to human acid sphingomyelinase (ASM) or sphingomyelin phosphodiesterase 1; the ASM-2 protein has a putative secretory signal peptide at the N-terminus, saposin-like and proline-rich domains and putative N-linked glycosylation sites; asm-2 shows phosphodiesterase activity when expressed in COS-7 cells; like mammalian ASM, asm-2 is probably both intracellular and secreted; northern blot analysis indicates that asm-2 is expressed during post-embryonic development as compared to asm-1 which is expressed at higher levels in the embryo; human ASM is implicated in Niemann-Pick disease type B (OMIM:607608). sphingomyelin phosphodiesterase ZK484.2 ZK484.2 haf-9; ZK484.2; 1G661; CE27353; CE33261; NM_059353; NM_182010; WBGene00001819; WP:CE27353; WP:CE33261 haf-9 is orthologous to the human gene ATP-BINDING CASSETTE, SUB-FAMILY B (MDR/TAP), MEMBER 3 (TAP2; OMIM:170261), which when mutated leads to disease. ZK546.14 ZK546.14 ZK546.14; 2F234; CE02914; CE33503; WBGene00022765; WP:CE02914; WP:CE33503 ZK637.13 ZK637.13 ZK637.13; 3K12; CE36418; WBGene00014030; WP:CE36418 Globin ZK652.4 ZK652.4 rpl-35; ZK652.4; 3I945; CE00450; NM_066301; WBGene00004449; WP:CE00450 rpl-35 encodes a large ribosomal subunit L35 protein. 60S ribosomal protein L35 ZK662.2 ZK662.2 ZK662.2; CE15377; WBGene00014039; WP:CE15377; XQ315 ZK666.6 ZK666.6 clec-60; ZK666.6; 2K770; CE02391; WBGene00014046; WP:CE02391 von Willebrand factor type A domain ZK666.7 ZK666.7 clec-61; ZK666.7; 2K780; CE02392; WBGene00014047; WP:CE02392 Lectin C-type domain short and long forms, von Willebrand factor type A domain ZK673.1 ZK673.1 ZK673.1; 2K735; CE16742; WBGene00014057; WP:CE16742 ZK678.5 ZK678.5 wrt-4; ZK678.5; CE24735; NM_078192; WBGene00006950; WP:CE24735; WRT4_CAEEL; XQ372 wrt-4 encodes a hedgehog-like protein, with (from N- to C-terminus) a signal sequence, a Wart domain, an short region of low-complexity sequence, and a Hint/Hog domain; WRT-4 is expressed strongly in hypodermal syncytia hyp6-hyp10 from 3-fold embryos to adults; the Hint/Hog domain is predicted to cut WRT-4 into two halves and then covalently link cholesterol to the C-terminus of the Wart domain; the Wart domain is predicted to form a cysteine-crosslinked protein involved in intercellular signalling, and it has subtle similarity to the N-terminal Hedge domain of HEDGEHOG proteins; WRT-4 is weakly required for normal molting; WRT-4 is also required for normal adult alae formation, growth to full size, locomotion, and male tail development; all of these requirements may reflect common defects in cholesterol-dependent hedgehog-like signalling or in vesicle trafficking. Hint module ZK686.2 ZK686.2 ZK686.2; 3I854; CE34464; WBGene00022792; WP:CE34464 ATP-dependent RNA helicase ZK742.3 ZK742.3 ZK742.3; 5I288; CE07639; WBGene00022813; WP:CE07639 ZK795.3 ZK795.3 ZK795.3; 4N325; CE18464; WBGene00014083; WP:CE18464 ZK836.1 ZK836.1 lon-3; ZK836.1; 5M678; CE15415; LON3_CAEEL; WBGene00003057; WP:CE15415 collagen ZK84.1 ZK84.1 ZK84.1; 2G313; CE02924; WBGene00022649; WP:CE02924 ZK863.1 ZK863.1 ZK863.1; 5M648; CE40187; WBGene00014122; WP:CE40187 7 transmembrane receptor (rhodopsin family) ZK896.5 ZK896.5 ZK896.5; 4N642; CE28276; WBGene00014136; WP:CE28276 ZK899.4 ZK899.4 tba-8; ZK899.4; CE37468; NM_077190; WBGene00006534; WP:CE37468; XK74 tba-8 encodes a member of the alpha tubulin family with high similarity to the human tubulin alpha-6 chain; expressed in some neurons with occasional expression in the hypodermis. tubulin alpha chain ZK945.3 ZK945.3 puf-12; ZK945.3; 2K391; CE01734; WBGene00014165; WP:CE01734 pumilio-repeat like domain