|Gene list file name:||Stetina2007_supp18|
|Type of gene identifier:||Cosmid name|
|Description:||Dauer genes are highly represented in the Pan neural datasets with a majority of dauer pathway genes being enriched|
|Organism:||Caenorhabditis elegans (nematode)|
|Gene list type:||Experimental|
Gene name Source Gene ID Annotation Date Added by
B0240.3 B0240.3 P W All gene names: daf-11; B0240.3; 5M200; CE05174; NM_073559; WBGene00000907; WP:CE05174 WormBase description: The daf-11 gene encodes a guanylate cyclase that affects dauer formation, chemotaxis, and axon formation; it is genetically upstream of daf-12 with respect to dauer larvae formation and is expressed in a subset of amphid neurons. WormBase CDS description: guanylate cyclase
B0334.8 B0334.8 P W All gene names: age-1; daf-23; B0334.8; 2L810; AGE1_CAEEL; CE23506; NM_064061; WBGene00000090; WP:CE23506 WormBase description: age-1 encodes the C. elegans ortholog of the phosphoinositide 3-kinase (PI3K) p110 catalytic subunit; AGE-1, supplied maternally and embryonically, is a central component of the C. elegans insulin-like signaling pathway, lying downstream of the DAF-2/insulin receptor and upstream of both the PDK-1 and AKT-1/AKT-2 kinases and the DAF-16 forkhead type transcription factor, whose negative regulation is the key output of the insulin signaling pathway; in accordance with its role in insulin signaling, AGE-1 activity is required for regulation of metabolism, life span, dauer formation, stress resistance, salt chemotaxis learning, fertility, and embryonic development; although the age-1 expression pattern has not yet been reported, ectopic expression studies indicate that pan-neuronal age-1 expression is sufficient to rescue life-span defects, while neuronal, intestinal, or muscle expression can partially rescue dauer formation, and neuronal or muscle expression can rescue metabolic defects. WormBase CDS description: phosphatidylinositol 3-kinase
B0412.2 B0412.2 P W All gene names: daf-7; B0412.2; 3B431; CE01758; NM_064864; WBGene00000903; WP:CE01758 WormBase description: daf-7 encodes a member of the transforming growth factor beta superfamily that affects dauer larvae formation in a TGF-beta-mediated pathway and also affects egg laying; expressed in the ASI neurons. WormBase CDS description: transforming growth factor beta proteins
C05D2.1 C05D2.1 P W All gene names: daf-4; C05D2.1; 3G721; CE16827; CE32114; CE33555; DAF4_CAEEL; NM_065810; WBGene00000900; WP:CE16827; WP:CE32114; WP:CE33555 WormBase description: daf-4 encodes a transmembrane serine/threonine kinase that is the sole C. elegans ortholog of the type II transforming growth factor-beta (TGF-b) receptors; DAF-4 activity is required for several biological processes, including entry into and exit from the dauer larval stage, body size determination, male tail patterning, egg laying, chemosensory neuron specification, and increased thermotolerance; in regulating dauer larval development, DAF-4 acts in parallel with the insulin signaling pathway and likely partners with the DAF-1 type I TGF-b receptor to receive a signal from the DAF-7 TGF-b ligand; in body size determination and male tail patterning, DAF-4 likely partners with the SMA-6 type I receptor and responds to signals from the DBL-1 ligand; DAF-4 expression begins in late embryogenesis and continues through larval and adult stages; consistent with its role in many developmental processes, DAF-4 localizes to the plasma membrane of several tissues including head and tail neurons, the pharynx, intestine, ventral nerve cord, tail hypodermis, and body wall muscle.
C12D8.10 C12D8.10 P W All gene names: akt-1; akt-1a; akt-1b; C12D8.10; 5K731; CE05274; CE15612; CE31304; WBGene00000102; WP:CE05274; WP:CE15612; WP:CE31304 WormBase description: akt-1 encodes an ortholog of the serine/threonine kinase Akt/PKB; akt-1 genetically interacts with the insulin signaling pathway and functions to regulate such processes as dauer larval development and salt chemotaxis learning; an AKT-1::GFP fusion protein is widely expressed beginning in late stage embryos and continuing through adulthood; expression is seen in head, tail, and dorsal and ventral cord neurons, with additional expression seen in other cells including those of the pharynx, hypodermis, intestine, and spermatheca; two alleles of akt-1 (sa573 and sa700) have a Daf-c mutant phenotype at 27 degrees C (Hid phenotype).
C47E8.5 C47E8.5 P W All gene names: daf-21; tax-3; C47E8.5; 5P167; CE05441; HSP90_CAEEL; NM_074225; WBGene00000915; WP:CE05441 WormBase description: daf-21 encodes a member of the Hsp90 family of molecular chaperones; DAF-21 activity is required for larval development, negative regulation of dauer larva formation, and a number of specific chemosensory behaviors, such as the response to chemicals and odorants detected by the ASE and AWC sensory neurons; a daf-21 sensory defect can be rescued by a cyclic GMP analogue, suggesting that, in regulating chemosensory behaviors, DAF-21 acts at a similar point as the DAF-11 guanylyl cyclase; down-regulation of daf-21 via RNAi results in a small but reproducible reduction in age-1 life span, suggesting that daf-21 is part of a chaperone network required for the extended life span seen in age-1 mutant animals. WormBase CDS description: heat shock protein (HSP90)
F01G10.8 F01G10.8 P W All gene names: daf-14; F01G10.8; 4L19; CE29090; NM_069479; WBGene00000910; WP:CE29090 WormBase description: daf-14 encodes a Smad-related protein that is unusual in that while its C-terminus is well-conserved with Smad proteins, it lacks the N-terminal DNA binding domain found in all other known Smads; DAF-14 is predicted to function as a transducer of the DAF-7/TGF-beta-mediated signal that promotes reproductive growth and negatively regulates dauer formation; as reduction of daf-14 function enhances the dauer constitutive phenotype of daf-8 mutants, and overexpression of daf-14 can rescue daf-8 mutant animals, it is likely that the DAF-14 and DAF-8 Smad proteins function in parallel to control dauer formation; further genetic analyses suggest that DAF-14 and DAF-8 function to antagonize the activities of the DAF-3 Smad and DAF-5 Sno/Ski oncoprotein, which are required for dauer formation; a DAF-14::GFP reporter is expressed in a dynamic pattern in tissues, such as the hypodermis, intestine, and pharynx, that are remodeled during dauer development. WormBase CDS description: Mouse MSMAD protein like
F13B12.5 F13B12.5 P W All gene names: aho-2; ins-1; F13B12.5; 4L201; CE27955; ILP1; NM_069525; WBGene00002084; WP:CE27955 WormBase description: ins-1 encodes an insulin-like peptide orthologous to human insulin (INS; OMIM:176730, mutated in hyperproinsulinemia and diabetes mellitus type II); INS-1 is one of 38 insulin-like peptides in C. elegans and when overexpressed can antagonize insulin-like signaling mediated by DAF-2/IR leading to arrest at the dauer larval stage; loss of INS-1, however, does not result in a dauer phenotype suggesting that INS-1 functions redundantly with other insulin-like peptides to regulate reproductive growth and lifespan; INS-1 is expressed in the amphid sensory neurons ASI and ASJ that regulate dauer arrest, the nerve ring, the intestine, vulval muscles, and other neurons.
F28H6.1 F28H6.1 P W All gene names: akt-2; F28H6.1; AKT2_CAEEL; CE18646; CE29298; NM_077956; WBGene00000103; WP:CE18646; WP:CE29298; XO769 WormBase description: akt-2 encodes a homolog of the serine/threonine kinase Akt/PKB, AKT-2, that is required for progression through the dauer stage of development and for the negative regulation of adult lifespan; inactivation of akt-2 causes animals to arrest constitutively at the dauer stage, while having an increased life span; widely expressed, AKT-2 is activated by the phospholipid products of phosphoinositide 3-kinase AGE-1/PI3K and by PDK-1, a homolog of vertebrate 3-phosphoinositide-dependent kinase-1 (PDK-1) Normal akt-2 (and akt-1) activity is required for excess pdk-1 activity to suppress the dauer-arrest phenotype of age-1, indicating that the 3-phosphoinositide-dependent kinase-1 homolog PDK-1 transduces signals from AGE-1 to AKT-2 (and AKT-1); conversely, the akt-2 loss-of-function phenotype is suppressed by daf-16 null mutations, indicating that the Fork head transcription factor DAF-16 is downstream of AKT-2 (and AKT-1), and that AKT-1 and AKT-2 act primarily to antagonize DAF-16. WormBase CDS description: PH (pleckstrin homology) domain, Protein kinase C terminal domain
R05D11.1 R05D11.1 P W All gene names: daf-8; smad-1; R05D11.1; CE06236; WBGene00000904; WP:CE06236 WormBase description: daf-8 encodes a Smad protein that represses dauer development, perhaps by antagonizing DAF-3 activity, and promotes a commitment to reproductive growth; genetic interactions suggest partial functional redundancy with daf-14 with respect to the TGF-beta signaling pathway that regulates dauer formation. WormBase CDS description: MAD protein
T07A9.6 T07A9.6 P W All gene names: daf-18; T07A9.6; 4B174; CE26385; NM_067525; WBGene00000913; WP:CE26385 WormBase description: daf-18 encodes a lipid phosphatase homologous to the human PTEN tumor suppresor (OMIM:601728, mutated in Cowden disease and several cancers); DAF-18 negatively regulates insulin-like signaling mediated by DAF-2/IR and AGE-1/PI3K and thus plays a role in metabolism, development, and longevity; based on sequence and genetic analysis, DAF-18 is predicted to dephosphorylate AGE-1-generated PIP3 in order to limit activation of the downstream AKT-1 and AKT-2 kinases that negatively regulate DAF-16.
W01G7.1 W01G7.1 P W All gene names: daf-5; W01G7.1; 2O324; CE18985; NM_064540; Q9XVH7_CAEEL; WBGene00000901; WP:CE18985 WormBase description: daf-5 encodes a proline-rich protein, conserved in C. briggsae but not observed in non-nematode genomes, that promotes dauer formation in the group II branch of the dauer pathway, may regulate chemosensation via AWC neurons, and may regulate egg laying; daf-5 mutations suppress the dauer phenotype of group II Daf-c mutants; daf-5(e1385) partially suppresses dauer formation by aex-6(sa699) mutants at 26.8 degrees C.
Y110A7A.10 Y110A7A.10 P W All gene names: aap-1; Y110A7A.10; 1F677; CE23248; NM_059121; Q9N597_CAEEL; WBGene00000001; WP:CE23248 WormBase description: aap-1 encodes the C. elegans ortholog of the phosphoinositide 3-kinase (PI3K) p50/p55 adaptor/regulatory subunit; AAP-1 negatively regulates lifespan and dauer development, and likely functions as the sole adaptor subunit for the AGE-1/p110 PI3K catalytic subunit to which it binds in vitro; although AAP-1 potentiates insulin-like signaling, it is not absolutely required for insulin-like signaling under most conditions.
Y116F11B.1 Y116F11B.1 P W All gene names: daf-28; Y116F11B.1; 5U275; CE25720; NM_075439; WBGene00000920; WP:CE25720 WormBase description: daf-28 encodes a beta-type insulin, mostly similar to INS-4 and INS-6 and homologous to human insulin; DAF-28 inhibits dauer formation; daf-28 mutants arrest as dauers and have downregulated signals through the DAF-2/insulin pathway; in young animals, daf-28 is expressed in ASI and ASJ neurons, which regulate dauer formation; in older animals, daf-28 expression spreads to other head neurons and to the somatic gonad; daf-28 expression is reduced by pheromone signalling, or in daf-1, daf-7, daf-11, or daf-22 mutant dauers; daf-28 mutants are dominant negative, and are suppressed by excess wild-type DAF-28, INS-4, or INS-6; normal loss-of-function daf-28 alleles are expected to have a normal phenotype because C. elegans' 38 insulin genes are likely to be redundant; daf-28 expression is increased in daf-6, osm-1, or tax-4 mutants; the transmembrane protein-tyrosine phosphatase IDA-1 is required for DAF-28 function; a ida-1 null allele enhances daf-28(sa191), with double mutants forming 50% dauers at 22.5 deg. C.
Y16B4A.1 Y16B4A.1 P W All gene names: unc-3; Y16B4A.1; CE29366; NM_078052; WBGene00006743; WP:CE29366; XP401 WormBase description: The unc-3 gene encodes a protein with homology to immunoglobulin (Ig) domain-containing transcription factors such as OLF-1 or SU(H). WormBase CDS description: transcription factor OLF-1 like
Y55D5A.5 Y55D5A.5 P W All gene names: daf-2; Y55D5A.5; Y55D5A_392.A; 3E86; CE27499; NM_065249; WBGene00000898; WP:CE27499 WormBase description: daf-2 encodes a predicted receptor tyrosine kinase that is the C. elegans insulin/IGF receptor ortholog; DAF-2 activity is required for a number of processes in C. elegans, including embryonic and larval development, formation of the developmentally arrested dauer larval stage, adult longevity, reproduction, fat storage, salt chemotaxis learning, and response to exogenous stressors such as high temperature or bacterial infection; DAF-2 signals through a conserved PI 3-kinase pathway to negatively regulate the activity of DAF-16, a Forkhead-related transcription factor, by inducing its phosphorylation and nuclear exclusion; amongst the 38 predicted insulin-like molecules in C. elegans, genetic and microarray analyses suggest that at least DAF-28, INS-1, and INS-7 are likely DAF-2 ligands; genetic mosaic and tissue-specific promoter studies indicate that daf-2 can function cell nonautonomously and within multiple cell types to influence dauer formation and adult lifespan, likely by regulating the production of secondary signals that coordinate growth and longevity throughout the animal.
ZC84.2 ZC84.2 P W All gene names: tax-4; ZC84.2; 3K275; CE27352; CNG_CAEEL; NM_066632; WBGene00006526; WP:CE27352 WormBase description: tax-4 is orthologous to the human gene ROD PHOTORECEPTOR CGMP-GATED CHANNEL (CNGA1; OMIM:123825), which when mutated leads to disease. WormBase CDS description: Cyclic-nucleotide-gated olfactory channel
ZK897.1 ZK897.1 P W All gene names: egl-22; unc-31; ZK897.1; 4N551; CE40493; NM_070036; WBGene00006767; WP:CE40493 WormBase description: unc-31 encodes a pleckstrin homology (PH) domain-containing protein orthologous to human calcium-dependent activator protein for secretion (CADPS, OMIM:604667); UNC-31 functions in post-docking calcium-regulated dense-core vesicle fusion that is required for egg laying, locomotion, pharyngeal pumping, and recovery from the dauer larval stage; in addition, UNC-31 functions in the insulin receptor signaling pathway that regulates adult life span where it may control Ca[2+]-regulated secretion of an insulin-like ligand. WormBase CDS description: PH (pleckstrin homology) domain