|Gene list file name:||Stetina2007_supp7|
|Type of gene identifier:||Cosmid name|
|Description:||Categorized larval pan-neural enriched genes with known expression patterns|
|Organism:||Caenorhabditis elegans (nematode)|
|Gene list type:||Experimental|
Gene name Source Gene ID Annotation Date Added by
B0001.1 B0001.1 P W All gene names: lin-24; B0001.1; 4M899; CE32786; Q17410_CAEEL; WBGene00003010; WBGene00007086; WP:CE32786
B0034.3 B0034.3 P W All gene names: casy-1; cdh-11; B0034.3; 2G236; CE27048; CE27049; CE39540; NM_062788; Q9BIB5_CAEEL; WBGene00000403; WP:CE27048; WP:CE27049; WP:CE39540 WormBase description: A homolog of a member of the cadherin superfamily which is involved in cell-cell adhesion.
B0207.12 B0207.12 P W All gene names: avr-14; gbr-2; B0207.12; 1G544; CE26421; CE30227; CE32092; WBGene00000232; WP:CE26421; WP:CE30227; WP:CE32092 WormBase description: avr-14 encodes an alpha-type subunit of a glutamate-gated chloride channel homologous to human GLRA2, which when mutated leads to hyperekplexia (OMIM:149400); AVR-14 affects sensitivity to the antiparisitic drug, ivermectin, in parallel with avr-15 and glc-1 and in a genetic pathway with unc-9; it functions in the extrapharyngeal nervous system, and is expressed in a subset of neurons in the ring ganglia, ventral cord, and some mechanosensory neurons.
B0280.12 B0280.12 P W All gene names: glr-2; B0280.12; 3I228; CE31400; CE33547; WBGene00001613; WP:CE31400; WP:CE33547 WormBase description: glr-2 encodes an AMPA (non-NMDA)-type ionotropic glutamate receptor subunit; GLR-2 activity is required for mediating the behavioral response to light nose touch and for regulating the frequency with which animals change locomotory direction in response to sensory cues such as food; GLR-2 and GLR-1, a second AMPA-type ionotropic glutamate receptor, can interact to form functional heteromeric channels; GLR-2 is expressed in many neurons, including four of the five pairs of command interneurons that are required for locomotory control.
B0350.2 B0350.2 P W All gene names: unc-44; B0350.2; 4G769; CE06702; CE06704; CE31147; CE31847; CE35821; CE37694; CE37695; Q17490_CAEEL; WBGene00006780; WP:CE06702; WP:CE06704; WP:CE31147; WP:CE31847; WP:CE35821; WP:CE37694; WP:CE37695 WormBase description: The unc-44 gene encodes an ankyrin-like protein required for proper sex myoblast and axonal guidance during development.
B0491.8 B0491.8 P W All gene names: ceclc-2; clh-2; B0491.8; C33B4.1; 2L659; CE02153; CE20461; CE27790; WBGene00000529; WP:CE02153; WP:CE20461; WP:CE27790 WormBase description: clh-2 encodes a chloride channel protein that is required for embryonic viability; may have two transcripts transcribed from alternative promoters, and the two transcripts might be expressed in different cell types.
B0564.10 B0564.10 P W All gene names: unc-30; B0564.10; 4N887; CE05183; CE36087; NM_070125; WBGene00006766; WP:CE05183; WP:CE36087 WormBase description: unc-30 encodes a homeodomain-containing protein that is orthologous to the Pitx family of homeodomain transcription factors; during develpoment, UNC-30 controls the terminal differentiation of all 19 type D GABA-ergic motor neurons by directly regulating the expression of UNC-25/GAD and UNC-47/VGAT, which regulate GABA formation and secretion, respectively; UNC-30 is expressed most strongly in type D motor neurons during early L1 and L2 larval stages. WormBase CDS description: homeobox protein (otd subfamily)
C01G10.11 C01G10.11 P W All gene names: unc-76; C01G10.11; 5P559; CE39210; CE39211; NM_074311; WBGene00006808; WP:CE39210; WP:CE39211 WormBase description: unc-76 encodes a predicted coiled-coil protein that belongs to the FEZ (fasciculation and elongation protein; zygin/zeta-1) family of proteins; UNC-76 activity is required for normal axonal outgrowth and fasciculation and hence, normal locomotion; UNC-76 expression begins during embryogenesis and is present in all axons throughout development; UNC-76 localizes to both axons and cell bodies. WormBase CDS description: UNC-76 protein
C02H7.1 C02H7.1 P W All gene names: C02H7.1; CE06757; WBGene00015363; WP:CE06757; XB385
C04F12.5 C04F12.5 P W All gene names: C04F12.5; 1K264; CE19678; WBGene00007299; WP:CE19678
C06A8.9 C06A8.9 P W All gene names: glr-4; C06A8.9; 2I76; CE31294; NM_063238; WBGene00001615; WP:CE31294 WormBase description: glr-4 encodes a putative non-NMDA ionotropic glutamate receptor subunit, most closely related to GLR-3 and less so to GLR-7, possibly of the kainate subfamily; glr-4 is expressed in various sensory neurons and interneurons from embyrogenesis onward; glr-4 expression requires UNC-42, as well as CFI-1 in URA cells. WormBase CDS description: Glutamate receptor
C06E1.4 C06E1.4 P W All gene names: glr-1; not-3; C06E1.4; 3J674; CE31407; NM_066486; WBGene00001612; WP:CE31407 WormBase description: glr-1 encodes an AMPA (non-NMDA)-type ionotropic glutamate receptor subunit; GLR-1 activity is required for mediating the behavioral response to light nose touch and the frequency with which animals change locomotory direction in response to sensory cues such as food; GLR-1 and GLR-2, a second AMPA-type ionotropic glutatmate receptor, can interact to form functional heteromeric channels; GLR-1 is expressed in motorneurons and interneurons, including four of the five pairs of command interneurons that are required for locomotory control; in the ventral nerve cord and nerve ring, GLR-1 localizes to perinuclear structures in cell bodies and to punctate structures that appear to be glutamatergic postsynaptic specializations; proper GLR-1 localization in the anterior ventral nerve cord of older larvae and adults requires activity of the class I PDZ protein LIN-10; GLR-1 is ubiquitinated in vivo and its abundance at postsynaptic elements, which may influence postsynaptic strength, is regulated by ubiquitination. WormBase CDS description: Glutamate receptor subunit
C07B5.3 C07B5.3 P W All gene names: C07B5.3; CE00893; WBGene00007408; WP:CE00893; XK140
C09C7.1 C09C7.1 P W All gene names: zig-4; C09C7.1; CE02468; NM_076934; WBGene00006981; WP:CE02468; XI545 WormBase description: IG-like C2-type domains
C09E7.3 C09E7.3 P W All gene names: oig-1; C09E7.3; 3H612; CE23536; NM_066038; WBGene00003859; WP:CE23536
C15A11.3 C15A11.3 P W All gene names: sol-1; C15A11.3; 1H966; CE36685; NM_059687; WBGene00004944; WP:CE36685 WormBase description: CUB domain
C16E9.4 C16E9.4 P W All gene names: inx-1; opu-1; C16E9.4; CE31880; CE31881; NM_171716; WBGene00002123; WP:CE31880; WP:CE31881; XH564; pcr55 WormBase description: inx-1 encodes a predicted member of the innexin family; expressed in 4-6 anterior neurons.
C18C4.10 C18C4.10 P W All gene names: klc-2; C18C4.10; 5G58; CE27362; CE32802; CE32803; CE36917; KLC_CAEEL; WBGene00002215; WP:CE27362; WP:CE32802; WP:CE32803; WP:CE36917 WormBase description: klc-2 encodes a kinesin light chain and was identified as a protein that interacts with UNC-16 by the yeast two-hybrid system, this association suggests that KLC-2 may be involved in the regulation of synaptic vesicle localization by the UNC-16-JNK signaling complex.
C18F10.2 C18F10.2 P W All gene names: C18F10.2; 3H365; CE30607; WBGene00015977; WP:CE30607
C18F3.2 C18F3.2 P W All gene names: lad-1; sax-7; C18F3.2; 4I847; CE37202; CE38779; CE38935; CE38936; NM_068948; WBGene00004732; WP:CE37202; WP:CE38779; WP:CE38935; WP:CE38936 WormBase description: sax-7 encodes the C. elegans ortholog of L1CAM; SAX-7 is ubiquitously expressed at sites of cell-cell contact, and is required for germline development, embryonic morphogenesis, and gonadal morphogenesis; SAX-7 interacts physically with the ankyrin UNC-44, and nonphosphorylated SAX-7 is colocalized with UNC-44 at sites of cellular contact in vivo.
C18H9.7 C18H9.7 P W All gene names: rpy-1; C18H9.7; 2G994; CE01807; NM_062964; Q09485_CAEEL; WBGene00004507; WP:CE01807 WormBase description: rpy-1 is orthologous to the human gene 43KDA ACETYLCHOLINE RECEPTOR-ASSOCIATED PROTEIN (RAPSN; OMIM:601592), which when mutated leads to congenital myasthenic syndrome. WormBase CDS description: postsynaptic protein
C25A1.11 C25A1.11 P W All gene names: aha-1; C25A1.11; 1K770; CE08377; NM_060286; WBGene00000095; WP:CE08377 WormBase description: aha-1 encodes an ortholog of human aryl-hydrocarbon receptor nuclear translocator; interacts with AHR-1 and HIF-1 in vitro, requires HIF-1 for proper localization, and is expressed ubiquitously. WormBase CDS description: aryl hydrocarbon receptor nuclear translocator
C27H5.8 C27H5.8 P W All gene names: glc-4; C27H5.8; 2H462; CE32152; NM_063088; WBGene00001594; WP:CE32152 WormBase description: glc-4 encodes a predicted glutamate-gated chloride channel that affects ivermectin sensitivity and reversal behavior and genetically interacts with avr-14; expressed in neurons. WormBase CDS description: ligand-gated ionic channel
C28A5.4 C28A5.4 P W All gene names: ceh-43; C28A5.4; 3F536; CE05325; NM_065503; WBGene00000463; WP:CE05325 WormBase description: A homeobox protein of the Distal-less (Dll) class that is required for development of the anterior hypdermis during embryonic morphogenesis for cell adhesion; also affects embryonic and larval viability; it is predominantly expressed in the head hypdodermis, neuronal support cells and CAN neurons. WormBase CDS description: homeobox protein (distal-less subfamily)
C29F5.4 C29F5.4 P W All gene names: mps-1; C29F5.4; 2G582; CE02511; CE33602; NM_062862; WBGene00003403; WP:CE02511; WP:CE33602
C30A5.7 C30A5.7 P W All gene names: unc-86; C30A5.7; 3J304; CE00098; CE00099; WBGene00006818; WP:CE00098; WP:CE00099 WormBase description: unc-86 encodes a transcription factor with a POU-type homeodomain that is required for correct fate determination and differentiaion in diverse neuronal lineages, including those of egg-laying neurons, mechanosensory neurons, and chemosensory interneurons; UNC-86 is orthologous to human BRN-3; UNC-86 is required for tph-1 and cat-1 expression in specific serotonergic neurons, as well as for neurite outgrowth. WormBase CDS description: Pou homeodomain
C32D5.9 C32D5.9 P W All gene names: lgg-1; C32D5.9; 2G636; CE01849; LGG1_CAEEL; NM_062876; WBGene00002980; WP:CE01849
C33A12.4 C33A12.4 P W All gene names: C33A12.4; 4K274; CE05350; WBGene00007883; WP:CE05350
C33D12.1 C33D12.1 P W All gene names: ceh-31; C33D12.1; CE39566; NM_076124; WBGene00000452; WP:CE39566; XD686 WormBase description: ceh-31 encodes a protein containing a homeobox domain. WormBase CDS description: homeobox protein
C34B4.1 C34B4.1 P W All gene names: frm-6; max-1; C34B4.1; 5N580; CE40604; CE40605; WBGene00003143; WP:CE40604; WP:CE40605 WormBase description: max-1 encodes a novel, conserved PH/MyTH4/FERM domain-containing protein; max-1 activity is required cell-autonomously in motor neurons for UNC-6-mediated, dorsally directed axon guidance, proper axon extension and axon fasciculation in the nerve cords, and fully normal backward locomotion; genetic analyses indicate that max-1 likely acts downstream of unc-6 and unc-5, and in parallel to unc-40 and unc-129, to regulate axon guidance; max-1 expression begins during later stages of embryogenesis and continues through adulthood; expression is seen in motor neurons that extend circumferential processes, other neurons and, for the short form of MAX-1, body wall muscles; in neurons, MAX-1 localizes to processes but is excluded from cell bodies in a manner dependent upon the FERM domain, which appears critical for MAX-1 function.
C35E7.11 C35E7.11 P W All gene names: C35E7.11; CE27830; WBGene00016463; WP:CE27830
C36F7.4 C36F7.4 P W All gene names: rig-5; C36F7.4; 1K142; CE24830; CE33980; NM_060134; NM_060135; WBGene00004372; WP:CE24830; WP:CE33980 WormBase description: Drosophila amalgam protein like
C37E2.4 C37E2.4 P W All gene names: ceh-36; C37E2.4; CE08623; NM_077964; WBGene00000457; WP:CE08623; XO802 WormBase description: ceh-36 encodes a paired-like homeodomain transcription factor that is one of three orthodenticle (OTD)-like homeodomain proteins in C. elegans (the others being ttx-1 and ceh-37); CEH-36 is required broadly for specification of the AWC olfactory neuron and also for establishing the left-right asymmetry of the ASEL and ASER gustatory neurons; in addition, CEH-36 is sufficient to specify the AFD thermosensory neuron fate in some cell types; CEH-36 is expressed in the AWC and ASE chemosensory neurons. WormBase CDS description: Homeobox domain
C39F7.1 C39F7.1 P W All gene names: C39F7.1; 5B741; CE16904; WBGene00016538; WP:CE16904
C40H5.5 C40H5.5 P W All gene names: ttx-3; C40H5.5; CE27107; NM_077569; WBGene00006654; WP:CE27107; XM384 WormBase description: ttx-3 encodes a LIM homeodomain protein required for functions of the interneuron AIY, including thermosensory behavior and olfactory learning. WormBase CDS description: LIM domain containing proteins (2 domains), homeobox protein (lim subfamily)
C41G7.5 C41G7.5 P W All gene names: ahr-1; C41G7.5; 1K107; CE20561; CE38293; NM_060129; WBGene00000096; WP:CE20561; WP:CE38293 WormBase description: ahr-1 encodes an aryl hydrocarbon receptor (ligand-activated basic helix-loop-helix transcription factor) ortholog that biochemically resembles its vertebrate relatives (OMIM:600253) which mediate the carcinogenic and teratogenic effects of environmental toxins; AHR-1 binds HSP90 tightly, and forms a dimer with AHA-1 that binds DNA fragments containing the mammalian xenobiotic response element; AHR-1 is expressed in neurons, and may play a role in neuronal migration.
C42D8.4 C42D8.4 P W All gene names: ets-5; C42D8.4; CE04205; WBGene00016600; WP:CE04205; XF694 WormBase description: DNA-binding protein
C44B11.3 C44B11.3 P W All gene names: Alpha-tubulin; mec-12; tba-3; C44B11.3; 3E222; CE24843; NM_065262; WBGene00003175; WP:CE24843 WormBase description: mec-12 encodes a novel C. elegans alpha-tubulin that is unique amongst C. elegans alpha tubulins in that it may be subject to post-translational acetylation; MEC-12 is required for normal mechanosensory response to gentle touch, and specifically for formation of the 15-protofilament microtubule bundle present in the touch receptor neurons; mec-12 interacts genetically with mec-5, which encodes a unique C. elegans collagen secreted by the hypodermis; MEC-12 is highly expressed in the touch neurons as well as in several other neurons that do not contains the microfilament bundle, such as the ventral cord motorneurons. WormBase CDS description: alpha tubulin
C44E12.3 C44E12.3 P W All gene names: twk-17; C44E12.3; CE30900; CE30901; CE30902; CE30903; CE33919; CE37886; N2P17; WBGene00006671; WP:CE30900; WP:CE30901; WP:CE30902; WP:CE30903; WP:CE33919; WP:CE37886; XI220
C45B2.4 C45B2.4 P W All gene names: gbr-5; ggr-2; C45B2.4; CE39337; CE39338; WBGene00001587; WP:CE39337; WP:CE39338; XG699 WormBase description: ggr-2 encodes a predicted member of the GABA/ glycine receptor family of ligand-gated chloride channels that affects thermotaxis; expressed in neurons that include SMDV, SMDD, SIAV, CAN, HSN, DD, and is weakly expressed in the egg-laying muscles.
C47C12.6 C47C12.6 P W All gene names: deg-1; C47C12.6; CE24854; NM_076910; WBGene00000950; WP:CE24854; XI393 WormBase description: deg-1 encodes a putative ion channel for which altered function induces necrotic cell death of neurons required for mechanosensory behavior; expressed in the ASH, IL1, AVD, AVG, and PVC neurons in addition to some muscle cells.
C48A7.1 C48A7.1 P W All gene names: eat-12; egl-19; pat-5; C48A7.1; 4I183; CE28820; CE31165; NM_171379; WBGene00001187; WP:CE28820; WP:CE31165 WormBase description: egl-19 encodes an ortholog of the alpha subunit of mammalian L-type calcium ion channels that affects muscle contraction in late embryonic morphogenesis, movement, egg-laying, mating and feeding; egl-19 is expressed in muscle cells and some neurons.
C48D1.3 C48D1.3 P W All gene names: cho-1; C48D1.3; 4N974; CE27109; NM_070138; SC5A7_CAEEL; WBGene00000501; WP:CE27109 WormBase description: cho-1 encodes a high-affinity choline transporter orthologous to members of the sodium-dependent glucose transporter family; CHO-1 is expressed in cholinergic neurons. WormBase CDS description: choline transporter
C50D2.2 C50D2.2 P W All gene names: C50D2.2; 2A399; CE08887; WBGene00016806; WP:CE08887 WormBase description: amino acid permease
C52E12.2 C52E12.2 P W All gene names: klp-1; unc-104; C52E12.2; 2H299; CE30267; CE33041; NM_171017; WBGene00006831; WP:CE30267; WP:CE33041 WormBase description: The unc-104 gene encodes a kinesin-like motor protein homologous to human axonal transporter of synaptic vesicles (ATSV, OMIM: 601255), and is required for anterograde axonal transport of synaptic vesicles as well as differentiation of pre- and postsynaptic domains at inhibitory neuromuscular junctions; UNC-104 is expressed solely in neurons.
C53B7.1 C53B7.1 P W All gene names: rig-3; C53B7.1; CE06971; NM_076754; WBGene00004370; WP:CE06971; XH479
D1007.1 D1007.1 P W All gene names: ceh-17; ceh-42; D1007.1; 1F138; CE09036; NM_058992; WBGene00000440; WP:CE09036 WormBase description: ceh-17 encodes a phox-2-like homeodomain protein that is a member of the Q50 paired-like class of homeobox proteins and the vertebrate orthologue of Phox2a and Phox2b; that affects ALA and SIA axonal development; ceh-17 affects ALA and SIA antero-posterior axonal growth and navigation, and is expressed in five neurons of the ring ganglia (ALA and the 4 SIAs) with strongest expression in embryos and in L1 stage larvae. WormBase CDS description: homeobox protein
D1009.5 D1009.5 P W All gene names: dylt-2; xbx-2; D1009.5; CE04289; NM_077110; WBGene00017014; WP:CE04289; XJ558
D2007.2 D2007.2 P W All gene names: D2007.2; 3J241; CE00127; WBGene00017042; WP:CE00127 WormBase description: D2007.2 is orthologous to the human gene TRANSKETOLASE (WERNICKE-KORSAKOFF SYNDROME) (TNF; OMIM:606781), which when mutated leads to disease.
E02H4.1 E02H4.1 P W All gene names: del-1; E02H4.1; CE05547; NM_077979; WBGene00000952; WP:CE05547; XO895 WormBase description: del-1 encodes an ion channel protein of the DEG/ENaC (degenerin/epithelial Na+ channel) family; like other members of the degenerin family, DEL-1 is predicted to function as a sensory mechanotransduction channel, however detailed analysis of the DEL-1 mutant phenotype has not yet been reported; DEL-1 is expressed postembryonically in the VA and VB motor neurons and in the FLP sensory neurons; the DEL-1 expression pattern overlaps that of UNC-8, an additional C. elegans degenerin involved in movement control, with which DEL-1 may coassemble to form mechanically activated cation channels. WormBase CDS description: mechanosensory protein
F01D4.6 F01D4.6 P W All gene names: mec-3; F01D4.6; 4L224; CE27422; CE34792; NM_069530; WBGene00003167; WP:CE27422; WP:CE34792 WormBase description: mec-3 encodes a founding member of the LIM (Lin-11, Isl-1, Mec-3) homeodomain family of transcriptional regulators; during C. elegans development, MEC-3 activity is required for proper differentiation and maturation of the mechanosensory neurons; MEC-3 is expressed in the mechanosensory neurons, where initiation of expression is dependent upon the UNC-86 homeodomain protein and maintenance of expression is dependent upon MEC-3 itself and mec-17.
F01G10.8 F01G10.8 P W All gene names: daf-14; F01G10.8; 4L19; CE29090; NM_069479; WBGene00000910; WP:CE29090 WormBase description: daf-14 encodes a Smad-related protein that is unusual in that while its C-terminus is well-conserved with Smad proteins, it lacks the N-terminal DNA binding domain found in all other known Smads; DAF-14 is predicted to function as a transducer of the DAF-7/TGF-beta-mediated signal that promotes reproductive growth and negatively regulates dauer formation; as reduction of daf-14 function enhances the dauer constitutive phenotype of daf-8 mutants, and overexpression of daf-14 can rescue daf-8 mutant animals, it is likely that the DAF-14 and DAF-8 Smad proteins function in parallel to control dauer formation; further genetic analyses suggest that DAF-14 and DAF-8 function to antagonize the activities of the DAF-3 Smad and DAF-5 Sno/Ski oncoprotein, which are required for dauer formation; a DAF-14::GFP reporter is expressed in a dynamic pattern in tissues, such as the hypodermis, intestine, and pharynx, that are remodeled during dauer development. WormBase CDS description: Mouse MSMAD protein like
F07F6.6 F07F6.6 P W All gene names: nmr-1; F07F6.6; 2F732; CE30128; NM_062632; WBGene00003774; WP:CE30128 WormBase description: nmr-1 encodes an NMDA-type ionotropic glutamate receptor subunit that affects the duration of forward movement which is important during foraging behavior, and also affects osmotic avoidance; the slow kinetics typical of NMDA-dependent currents are likely important for its effect on forward movement. WormBase CDS description: Glutamate receptor
F08A10.1 F08A10.1 P W All gene names: F08A10.1; 1I783; CE32354; CE32355; CE32356; CE36995; WBGene00008570; WP:CE32354; WP:CE32355; WP:CE32356; WP:CE36995
F08B12.3 F08B12.3 P W All gene names: slo-2; F08B12.3; CE09233; CE18570; CE38315; WBGene00004831; WP:CE09233; WP:CE18570; WP:CE38315; XM14 WormBase description: slo-2 encodes a high-conductance potassium channel; by homology, SLO-2 is predicted to play a role in regulating cellular excitability, however loss of slo-2 activity via large-scale RNAi screens does not result in any obvious abnormalities; when expressed in Xenopus oocytes, SLO-2 exhibits a synergistic dependence on both calcium and chloride; in addition, expression of a dominant negative SLO-2 mutant can interfere with activity of SLO-1, an additional high-conductance potassium channel, suggesting that the two channels can form functional heteromultimers; a SLO-2::GFP fusion protein is expression in body-wall, vulval, and pharyngeal-intestinal valve muscles, nerve ring processes, and some motor neurons in the ventral nerve cord in a pattern that largely overlaps that of SLO-1.
F08F8.3 F08F8.3 P W All gene names: F08F8.3; CE27931; CE30650; WBGene00002182; WP:CE27931; WP:CE30650
F09B9.2 F09B9.2 P W All gene names: unc-115; F09B9.2; CE02176; CE15759; NM_077301; WBGene00006839; WP:CE02176; WP:CE15759; XK771 WormBase description: unc-115 encodes a protein that binds actin filaments and that is required for RAS signalling and UNC-40/netrin activity during axon pathfinding. WormBase CDS description: LIM domains
F10E7.9 F10E7.9 P W All gene names: F10E7.9; 2H398; CE04364; WBGene00017350; WP:CE04364 WormBase description: bumetanide-sensitive Na-K-Cl cotransporter
F11C3.2 F11C3.2 P W All gene names: cof-1; ofm-1; unc-122; F11C3.2; 1P467; CE20668; NM_061197; WBGene00006845; WP:CE20668 WormBase description: unc-122 encodes a predicted type II transmembrane protein with extracellular collagen-like domains and a highly conserved olfactomedin (OLF) domain that is found in a family of secreted proteins involved in formation and function of nervous systems; UNC-122 is required for proper locomotion and for normal morphology of the DVB motorneuron, and may regulate neuromuscular function by acting in an aminergic/peptidergic pathway parallel to cholinergic neurotransmission; although mosaic analysis indicates that UNC-122 activity is required in muscle cells, the precise expression and localization patterns of UNC-122 are not yet known.
F12F3.1 F12F3.1 P W All gene names: exp-2; F12F3.1; 5G623; CE09359; CE37629; CE37630; CE37631; WBGene00001374; WP:CE09359; WP:CE37629; WP:CE37630; WP:CE37631 WormBase description: exp-2 encodes a member of the six-transmembrane voltage-activated (Kv-type) family of potassium channels; exp-2 is required for normal pharyngeal muscle action potentials and hence, for normal feeding behavior; in addition, exp-2 is required for chemotaxis; when expressed in Xenopus oocytes, EXP-2 displays inward rectifying currents, however when assessed in endogenous pharyngeal tissue, EXP-2 displays hyperpolarization-activated outward currents; an EXP-2 translational reporter fusion is expressed strongly in pharyngeal muscles, amphid, phasmid, and head neurons, posterior enteric muscles, and occasionally faintly in the egg-laying muscles.
F14D12.4 F14D12.4 P W All gene names: mec-2; F14D12.4; CE04393; CE30952; CE37633; NM_171691; WBGene00003166; WP:CE04393; WP:CE30952; WP:CE37633; XG209 WormBase description: The mec-2 gene encodes a stomatin homolog required to sense gentle mechanical stimuli (e.g. touch) along the body wall.
F15G9.1 F15G9.1 P W All gene names: F15G9.1; CE01549; CE23660; CE32382; WBGene00008865; WP:CE01549; WP:CE23660; WP:CE32382; XK325
F16F9.5 F16F9.5 P W All gene names: deg-2; mec-10; F16F9.5; CE09444; NM_077037; WBGene00003174; WP:CE09444; XJ86 WormBase description: The mec-10 gene encodes an amiloride-sensitive Na+ channel protein (degenerin) required to sense gentle mechanical stimuli (e.g. touch) along the body wall; it is paralogous to mec-4, which has similar function in vivo. WormBase CDS description: degenerin
F18C12.1 F18C12.1 P W All gene names: avr-1; caf-2; che-3; che-8; osm-2; F18C12.1; 1I638; CE32386; NM_059820; WBGene00000485; WP:CE32386 WormBase description: The dynein heavy chain (DHC) 1b isoform that affects the establishment and maintainance of the structural integrity of sensory cilia and also has a role in intraflagellar transport; it is expressed in ciliated sensory neurons. WormBase CDS description: dynein heavy chain
F20C5.2 F20C5.2 P W All gene names: klp-11; F20C5.2; 4J520; CE03239; CE27986; NM_171407; Q8MQ68_CAEEL; WBGene00002222; WP:CE03239; WP:CE27986; krp95 WormBase description: klp-11 encodes a predicted kinesin protein with high similarity to OSM-3 in the motor domain and encodes one of the motor subunits of heterotrimeric CeKinesin-II; expressed throughout the nervous system. WormBase CDS description: kinesin
F20D1.10 F20D1.10 P W All gene names: tag-299; F20D1.10; CE23677; WBGene00008980; WP:CE23677; XP599
F25E2.5 F25E2.5 P W All gene names: daf-3; F25E2.5; CE26364; CE28002; CE30963; NM_075760; Q95QI7_CAEEL; WBGene00000899; WP:CE26364; WP:CE28002; WP:CE30963; XB438 WormBase description: daf-3 encodes a Smad protein; DAF-3 functions as a transcriptional regulator that is required for formation of the alternative dauer larval stage; DAF-3 activity is antagonized by signaling through the DAF-7/TGF-beta pathway which promotes reproductive growth; in yeast two-hybrid studies, DAF-3 interacts with SMA-3, another Smad protein that does not appear to have a role in dauer formation; a DAF-3::GFP fusion protein is expressed in many tissues that undergo remodeling during dauer development; DAF-3 localizes predominantly to the cytoplasm, but is also found associated with chromosomes in mitotic cells.
F26C11.2 F26C11.2 P W All gene names: ceh-4; unc-4; F26C11.2; 2K188; CE01560; NM_063737; UNC4_CAEEL; WBGene00006744; WP:CE01560 WormBase description: The unc-4 gene encodes a paired-class homeodomain protein with homologs in Drosophila and vertebrates; UNC-4 is required for establishing the identity of the A class motor neurons DA and VA, and is thus required for movement, axon guidance, and synapse formation; UNC-4 is negatively regulated by VAB-7, and UNC-4 activity requires UNC-37; unc-4 is expressed in the A-type motor neurons, DA and VA, the six VC motor neurons that innervate the vulval muscles, and the three SAB motor neurons; unc-4 is also expressed in the pharyngeal I5 motor neuron and the AVF neurons in the retrovesicular ganglion. WormBase CDS description: homeobox protein (otd subfamily)
F26D11.10 F26D11.10 P W All gene names: inx-4; opu-4; F26D11.10; 5I436; CE17712; NM_072649; WBGene00002126; WP:CE17712
F26E4.8 F26E4.8 P W All gene names: tba-1; F26E4.8; 1K362; CE09692; NM_060199; O18688_CAEEL; TUBA3; WBGene00006528; WP:CE09692 WormBase description: TBA-2 tubulin alpha-2 chain
F29C4.1 F29C4.1 P W All gene names: daf-1; F29C4.1; 4A889; CE17719; CE31492; DAF1_CAEEL; WBGene00000897; WP:CE17719; WP:CE31492 WormBase description: daf-1 encodes a TGF-beta type I receptor homolog required, in association with the TGF beta-like type II receptor DAF-4, for the regulation of dauer formation by environmental signals through the ASI chemosensory neuron; DAF-1 is bound by BRA-1 and has an intracellular serine-threonine kinase domain; mutations in daf-1 result in constitutive formation of dauer larvae even in abundant food. WormBase CDS description: protein kinase
F33H1.1 F33H1.1 P W All gene names: daf-19; daf-24; F33H1.1; 2K448; CE17763; CE28019; WBGene00000914; WP:CE17763; WP:CE28019 WormBase description: daf-19 is the sole C. elegans member of the RFX family of transcription factors, and is required for sensory neuron cilium formation; DAF-19 is expressed in ciliated sensory neurons during the period that their cilia are generated, and probably functions as an common transcriptional activator of many genes that specifically encode cilial structures in sensory neurons; daf-19 mutants lack sensory cilia, have abnormal amphids, are strongly dauer-constutive, lack normal openings of the amphids to the external environment (i.e., fail to show dye-filling), and are highly defective in their ability to taste or smell; DAF-19 regulates bbs-5, che-2, che-13, dyf-3, osm-1, osm-6, and xbx-1 expression, and probably regulates ~200 other genes (e.g., bbs-2, bbs-7 and bbs-8); the localization of DAF-6 is aberrant in daf-19 mutants. WormBase CDS description: DNA binding transcription factor
F34H10.2 F34H10.2 P W All gene names: F34H10.2; CE01572; WBGene00009379; WP:CE01572; XK247
F36A2.4 F36A2.4 P W All gene names: twk-30; F36A2.4; 1J386; CE34182; NM_059980; WBGene00006682; WP:CE34182 WormBase description: potassium channel protein
F39C12.2 F39C12.2 P W All gene names: add-1; F39C12.2; CE28308; CE28309; CE29794; CE30979; CE34553; WBGene00000072; WP:CE28308; WP:CE28309; WP:CE29794; WP:CE30979; WP:CE34553; XF474 WormBase description: add-1 encodes an ortholog of the cytoskeletal protein alpha-adducin (ADD1, OMIM:102680, mutations are associated with susceptibility to salt-sensitive essential hypertension); by homology, ADD-1 is predicted to be a cell membrane-associated protein that mediates localized changes in the cytoskeleton in response to activation of signal transduction cascades; as loss of add-1 activity via large-scale RNAi screens does not result in any obvious abnormalities, the precise role of ADD-1 in C. elegans development and/or behavior is not yet known.
F40E10.2 F40E10.2 P W All gene names: sox-3; F40E10.2; CE05838; NM_078038; WBGene00004950; WP:CE05838; XP308 WormBase description: sex-determining protein SOX3 like
F40F9.1 F40F9.1 P W All gene names: xbx-6; F40F9.1; 5K187; CE31343; CE31344; NM_073099; NM_171511; Q8MQ56_CAEEL; WBGene00009580; WP:CE31343; WP:CE31344 WormBase description: N-methyl-D-aspartate receptor associated protein
F40H3.4 F40H3.4 P W All gene names: fkh-8; F40H3.4; 2G480; CE19865; NM_062834; WBGene00001440; WP:CE19865 WormBase description: fkh-8 encodes one of 15 C. elegans forkhead transcription factors; loss of fkh-8 activity via RNAi has been reported to result in either no defects or a weakly penetrant aldicarb resistance phenotype; an FKH-8 reporter fusion is expressed in nerve cells in the head and tail ganglia of both males and hermaphrodites with expression beginning in the later stages of embryogenesis and continuing through adulthood.
F41C6.1 F41C6.1 P W All gene names: unc-106; unc-6; F41C6.1; CE04538; NM_076764; WBGene00006746; WP:CE04538; XH515 WormBase description: unc-6 encodes a netrin orthologous to the human and mouse netrin-1 precursor proteins; UNC-6 functions as a guidance molecule that regulates the migrations of pioneer axons and mesodermal cells, such as the gonadal distal tip cell, along the dorsoventral axis; a secreted molecule, UNC-6 is expressed during embryogenesis by epidermoblasts and neurons; UNC-6 is involved in both attractive and repulsive interactions that are mediated by the UNC-40 and UNC-5 netrin receptors, respectively.
F41D9.3 F41D9.3 P W All gene names: wrk-1; F41D9.3; CE30985; CE30986; CE30987; CE34015; CE37643; WBGene00006942; WP:CE30985; WP:CE30986; WP:CE30987; WP:CE34015; WP:CE37643; XJ6
F41E6.4 F41E6.4 P W All gene names: smk-1; F41E6.4; 5J95; CE33782; CE37911; CE37912; WBGene00018285; WP:CE33782; WP:CE37911; WP:CE37912 WormBase description: smk-1 encodes a novel, evolutionarily conserved protein that is orthologous to the mammalian and Dictyostelium discoideum SMEK (suppressor of MEK null) proteins; smk-1 activity is essential for several aspects of DAF-16-mediated longevity namely, the defense response to pathogenic bacteria and increased resistance to oxidative and UV-induced damage; in regulating DAF-16 activity, SMK-1 appears to act by affecting the transcription of DAF-16 target genes, such as sod-3, ctl-1, and lys-8; SMK-1 is present in the nucleus of intestinal cells, many head and tail neurons, and some hypodermal cells throughout development.
F42F12.2 F42F12.2 P W All gene names: zig-2; F42F12.2; CE03313; NM_077668; WBGene00006979; WP:CE03313; XM956 WormBase description: IG-like C2-type domains
F42G9.9 F42G9.9 P W All gene names: ptl-1; tau-1; F42G9.9; 3B387; CE24967; CE28321; CE28322; CE30793; Q95QG4_CAEEL; WBGene00004212; WP:CE24967; WP:CE28321; WP:CE28322; WP:CE30793 WormBase description: ptl-1 encodes a microtubule-binding protein that is homologous to members of the tau/MAP2/MAP4 subfamily of microtubule-associated proteins (OMIM:157140, abnormal aggregates of hyperphosphorylated tau are associated with several neurodegenerative disorders, including Alzheimer's disease, Pick's disease, and corticobasal degeneration); by homology, PTL-1 is predicted to promote microtubule assembly and stability, and to play a role in maintaining neuronal integrity and axonal transport; in vitro, bacterially expressed PTL-1 can bind microtubules; ptl-1 mRNA is expressed at highest levels in the embryo and early larval stages, while PTL-1 is detected in embryonic hypodermis and head neurons and then in the mechanosensory neurons, ALML, ALMR, AVM, PLML, and PLMR, in larvae and adults; as loss of ptl-1 function via mutation or large-scale RNAi screens does not result in any obvious abnormalities, the precise role of PTL-1 in C. elegans development and/or behavior is not yet known.
F43C9.4 F43C9.4 P W All gene names: mig-13; F43C9.4; CE28324; CE34562; NM_076419; WBGene00003245; WP:CE28324; WP:CE34562; XF416 WormBase description: mig-13 encodes a novel single-pass transmembrane protein with a N-terminal signal sequence and two motifs that have been implicated in protein-protein interactions: a CUB domain and a LDL receptor repeat; mig-13 affects the migration and thus the positioning of the Q neuroblasts and their descendants and also the anterior migration of the BDU neuron and may be a component of a global anterior/posterior migration system; a mig-13-gfp translational fusion protein is expressed in embryonic pharyngeal, hypodermal and anterior body neuronal precursors as well as in the cell bodies and axons of a number of neurons in the retrovascular ganglion and the ventral cord; mig-13 localizes to the plasma membrane; mig-13 expression along the A/P axis is restricted by hox gene activity.
F44F4.1 F44F4.1 P W All gene names: F44F4.1; 2L171; CE00996; WBGene00009700; WP:CE00996
F46A9.3 F46A9.3 P W All gene names: twk-29; F46A9.3; 1K45; CE32666; CE38354; WBGene00006681; WP:CE32666; WP:CE38354 WormBase description: potassium channel protein
F52B5.1 F52B5.1 P W All gene names: abts-1; F52B5.1; 1I874; CE27167; NM_059857; WBGene00009920; WP:CE27167 WormBase description: anion exchange protein
F53A9.4 F53A9.4 P W All gene names: F53A9.4; CE30141; WBGene00018727; WP:CE30141; XJ325
F55B12.1 F55B12.1 P W All gene names: ceh-24; F55B12.1; 5O295; CE25006; NM_074018; WBGene00000447; WP:CE25006 WormBase description: ceh-24 is orthologous to the human gene SIMILAR TO THYROID TRANSCRIPTION FACTOR 1 (TITF1; OMIM:600635), which when mutated leads to disease. WormBase CDS description: homeobox protein (NK-2 subfamily)
F56A11.3 F56A11.3 P W All gene names: efn-4; mab-26; F56A11.3; 4B319; CE29503; NM_067546; WBGene00001165; WP:CE29503 WormBase description: efn-4 encodes a member of the ephrin family of ligands that affects neuroblast migrations during closure of the ventral gastrulation cleft and subsequent epidermal morphogenesis, possibly functioning independently of EFN-1, EFN-2, EFN-3, and the VAB-1 receptor during morphogenesis; can interact with VAB-1 in vitro, and is expressed in neural and epidermal precursors at the 100-cell stage, in head neurons, pharyngeal cells, lateral and tail neurons, and in the ectoderm during epidermal enclosure.
F56A12.1 F56A12.1 P W All gene names: ceh-35; mig-3; unc-39; F56A12.1; 5O855; CE37921; NM_074162; O17894_CAEEL; WBGene00006775; WP:CE37921 WormBase description: unc-39 encodes a homeodomain transcription factor that belongs to the Six4/5 family of homeodomain proteins that includes human Six5; UNC-39 is required for axonal pathfinding in anterior-derived neurons and for specification of most mesodermal cell types and may regulate a developmental decision between migration and differentiation; UNC-39 is expressed in the embryo in anterior neurons, posteriorly derived mesoderm (somatic gonad, M mesoblast, and possibly the coelomocytes and muIntR), the CAN neurons, and body wall muscle. WormBase CDS description: so class homeobox protein
F56E3.3 F56E3.3 P W All gene names: klp-4; F56E3.3; CE04669; CE27176; CE31007; NM_076145; NM_171650; NM_171943; Q8MQ20_CAEEL; WBGene00002217; WP:CE04669; WP:CE27176; WP:CE31007; XD790 WormBase description: klp-4 encodes a kinesin-like motor protein paralogous to UNC-104 and KLP-6 and orthologous to Drosophila KHC-73 and the vertebrate KIF1A, KIF13B, and GAKIN motor proteins; as loss of KLP-4 function via RNA-mediated interference (RNAi) does not result in any abnormalities, the precise role of KLP-4 in C. elegans development and/or behavior is not yet known; based on sequence similarity, however, KLP-4 is predicted to play a role in neuronal development or function; a klp-4::gfp transcriptional reporter fusion is expressed in larvae and adults in the pharynx, intestine, and nervous system, including head and tail neurons, the nerve ring, and ventral nerve cord.
F56E3.4 F56E3.4 P W All gene names: fax-1; nhr-29; F56E3.4; CE28464; NM_076146; WBGene00001400; WP:CE28464; XD816 WormBase description: fax-1 encodes a predicted nuclear hormone receptor that contains two C4-type zinc fingers; FAX-1 is orthologous to the vertebrate photoreceptor-specific nuclear receptor (NR2E3 or PNR; OMIM:604485, mutated in enhanced S-cone syndrome and retinitis pigmentosa); FAX-1 is required for normal locomotion and for specification of neuronal identities, including pathfinding of the AVKR, AVKL, HSNL, and PVQL axons and expresion of the FMRFamide-like FLP-1 peptide neurotransmitter in AVKR and AVKL; FAX-1 is expressed in embryonic neurons, including the AVK interneurons, just prior to axon extension. WormBase CDS description: nuclear hormone receptor
F56F4.5 F56F4.5 P W All gene names: opt-3; F56F4.5; 1G713; CE11268; NM_059366; WBGene00003878; WP:CE11268 WormBase description: oligopeptide transporter
F57C7.3 F57C7.3 P W All gene names: sdn-1; F57C7.3; CE05996; CE32681; NM_171769; NM_171972; WBGene00004749; WP:CE05996; WP:CE32681; XL210 WormBase description: sdn-1 encodes a homolog of vertebrate syndecan-2, a type I transmembrane heparan sulfate proteoglycan; by homology, SDN-1 is predicted to play a role in cell-cell and cell-matrix adhesion; loss of sdn-1 activity via RNA-mediated interference (RNAi) indicates that SDN-1 is required for backward locomotion and for normal development of the egg-laying system, particularly gonadal and vulval structures; SDN-1 is expressed in a subset of neuronal cell bodies and their associated processes in the nerve ring, and also in select tail neurons. WormBase CDS description: syndecan like protein
F57H12.2 F57H12.2 P W All gene names: unc-24; F57H12.2; 4I745; CE17123; NM_068934; WBGene00006761; WP:CE17123 WormBase description: unc-24 encodes a protein that contains a stomatin-like domain and a lipid transfer domain; unc-24 activity is essential for normal locomotion and for wild-type sensitivity to lipid-soluble volatile anesthetics; unc-24 is genetically epistatic to unc-79 and to unc-1, which encodes an additional stomatin whose stability and localization to the nerve ring are dependent upon UNC-24; unc-24 is expressed in the touch receptor neurons as well as neurons in the ventral cord.
F58A3.1 F58A3.1 P W All gene names: ldb-1; F58A3.1; CE11350; CE11352; CE23789; NM_077443; NM_077444; NM_077445; WBGene00002261; WP:CE11350; WP:CE11352; WP:CE23789; XL657 WormBase description: ldb-1 encodes an Ldb/NLI/Clim member of the nuclear LIM binding protein family that affects coordinated locomotion, vulval development, mechanosensation, and growth of larvae and is required for transcriptional activation of mec-2; can interact with MEC-3 to activate transcription using yeast two-hybrid assays and is expressed in all neurons, vulval cells, gonadal sheath cells, and in some body muscle cells.
F58E6.10 F58E6.10 P W All gene names: unc-42; F58E6.10; 5K244; CE39164; NM_073118; Q20455_CAEEL; WBGene00006778; WP:CE39164 WormBase description: unc-42 encodes a paired-like homeodomain protein of the Q50 class; UNC-42 is required to specify the fate of ASH sensory neurons, AVA, AVD, and AVE interneurons, and a subset of motor neurons; unc-42 mutants fail to express cell-surface receptors required for differentiated neuronal function (sra-6, srb-6, glr-1, glr-5, and glr-6); UNC-42 is also required for AVKR and HSNL growth cones to follow the PVPR and PVQL pioneer axons, for axonal outgrowth in the backward command interneurons AVA, AVD, and AVE, and for inhibition of ectopic FMRFamide-positive and GABAergic axons; unc-42 mutants are defective in mechanosensation, backward motion, and regulation of egg-laying. WormBase CDS description: Homeobox domain
K02B12.1 K02B12.1 P W All gene names: ceh-6; K02B12.1; 1J76; CE28045; NM_059903; WBGene00000431; WP:CE28045 WormBase description: ceh-6 encodes a POU family homeodomain protein, homologous to human POU3F4 (OMIM:304400, mutated in conductive deafness 3) that affects embryonic viability, locomotion, and molting, and that regulates ectodermal and excretory function; CEH-6 is expressed dynamically during development and expression includes neurons, the excretory cell, and ectodermal cells. WormBase CDS description: Homeobox domain, Pou domain - N-terminal to homeobox domain
K02E10.8 K02E10.8 P W All gene names: syg-1; K02E10.8; CE37121; NM_076056; WBGene00006365; WP:CE37121; XD128 WormBase description: syg-1 encodes a novel transmembrane protein that is a member of the immunoglobulin superfamily of proteins; during larval development, SYG-1 activity is required cell autonomously within the HSNL neuron to specify proper synaptic specificity with its targets, such as vulval muscles and the VC neuron; in regulating synapse formation, SYG-1 acts as a receptor for a second immunoglobulin superfamily protein, SYG-2, a synaptic guidepost protein that interacts with SYG-1 and whose activity is essential for proper SYG-1 localization in HSNL; expression of a SYG-1::GFP reporter fusion in HSNL under the control of the unc-86 promoter reveals that SYG-1 localizes to axons and accumulates at future sites of synaptic vesicle clustering, while expression under an endogenous reporter reveals weak expression in head motorneurons, occasionally in HSN neurons, and in other cells in the vulval region.
K03B8.9 K03B8.9 P W All gene names: deg-3; K03B8.9; 5L894; CE06083; NM_073496; WBGene00000951; WP:CE06083 WormBase description: deg-3 encodes an alpha subunit of a nicotinic acetylcholine receptor (nAChR); originally defined by a gain-of-function mutation that results in neuronal degeneration and uncoordinated movement, DEG-3 can form heteromeric channels with a second alpha subunit, DES-2, and in vivo these channels appear to be required for chemosensation of choline; deg-3 and des-2 reside in an operon, and consistent with their role in metabolite chemosensation, are expressed in nonsynaptic regions such as the sensory endings of the IL2 chemosensory neurons; DEG-3 and DES-2 are also detected in the touch cell neurons, M1 head muscles, FLP and PVD sensory neurons, and the PVC interneuron; in subsets of these neurons, DEG-3 expression is not detectable in mec-3 or unc-86 mutant backgrounds. WormBase CDS description: nicotinic acetylcholine receptor
K03D10.1 K03D10.1 P W All gene names: kal-1; K03D10.1; 1O722; CE35892; NM_061067; WBGene00002181; WP:CE35892 WormBase description: kal-1 encodes a cell surface protein that contains a WAP-type protease inhibitor domain and Type III fibronectin domains and is the C. elegans ortholog of human KAL-1, mutated in the X-linked form of the neurological disorder Kallmann syndrome; in C. elegans, both kal-1 loss-of-function mutations and kal-1 overexpression result in similar phenotypes that indicate KAL-1 activity is required for epithelial morphogenesis and axon branching; kal-1 transcriptional reporters reveal expression beginning in the 50-cell stage embryo in 2-3 cells with later embryonic expression in at least 8-10 AB-derived ventral neuroblasts that are a substrate for migrating epidermal cells during ventral enclosure; later expression in larvae and adults is restricted to anterior neurons, including AIY, AIZ, RID, M5, ASI, and labial sensory neurons, ventral nerve cord motorneurons, midbody neurons HSN, CAN, and PVM, tail neurons DVB, DVC, and PDB, and the nonneuronal excretory cell as well as in uterine muscles; in the AIY interneurons, kal-1 is part of a gene battery whose expression is under the control of the CEH-10 and TTX-3 Paired and LIM-type homeodomains, respectively. WormBase CDS description: WAP-type (Whey Acidic Protein) 'four-disulfide core', Fibronectin type III domain (3 domains)
K03E6.5 K03E6.5 P W All gene names: unc-1; unc-102; K03E6.5; CE28585; NM_075801; WBGene00006741; WP:CE28585; XB678 WormBase description: unc-1 encodes a homolog of human stomatin (OMIM:133090; deficient in stomatocytosis); UNC-1 protein is found in major nerve tracts, particularly in the nerve ring; unc-1 is required for anesthetic sensitivity; unc-24, which also encodes a stomatin homolog, is epistatic to unc-1 and is required for UNC-1 localization to the nerve ring. WormBase CDS description: Erythrocyte band 7 intergral membrane protein
K04B12.1 K04B12.1 P W All gene names: plx-2; K04B12.1; 2O704; CE35575; NM_064600; WBGene00004048; WP:CE35575
K04F10.2 K04F10.2 P W All gene names: K04F10.2; 1G937; CE34333; WBGene00019395; WP:CE34333
K06C4.6 K06C4.6 P W All gene names: K06C4.6; 5J390; CE28590; CE30814; CE38391; NM_171495; WBGene00003386; WP:CE28590; WP:CE30814; WP:CE38391 WormBase description: mod-1 encodes a serotonin-gated chloride channel; MOD-1 activity is required for locomotory behavior, specifically for the experience-dependent behavior of an enhanced slowing response exhibited by food-deprived animals upon encountering a bacterial food source; when expressed in voltage-clamped Xenopus oocytes, MOD-1 is able to form a serotonin-gated ion channel, and when expressed in human tissue culture cells, MOD-1 exhibits behavior consistent with chloride selectivity; a rescuing MOD-1::GFP construct is expressed in the cell bodies and axons (the latter presumably due to overexpression) of neurons in the head, tail, and ventral nerve cord.
K07C11.10 K07C11.10 P W All gene names: K07C11.10; 5I706; CE35335; WBGene00019482; WP:CE35335
K08A8.2 K08A8.2 P W All gene names: sox-2; K08A8.2; CE28595; CE31200; NM_171725; NM_171726; WBGene00004949; WP:CE28595; WP:CE31200; XI78 WormBase description: The sox-2 gene encodes a homolog of human SRY, which when mutated leads to gonadal dysgenesis (OMIM:306100).
K08A8.3 K08A8.3 P W All gene names: rad-21.2; coh-1; K08A8.3; CE04726; NM_076861; WBGene00000591; WP:CE04726; XI84 WormBase description: coh-1 encodes a RAD21 homolog that affects embryonic viability and is believed to affect cohesion of sister chromatids in somatic cells; expressed in the distal tip cells of the gonad, embryonic, and somatic cells WormBase CDS description: S. pombe double-strand-break repair protein, RAD21
K08C7.4 K08C7.4 P W All gene names: K08C7.4; 4L444; CE35587; WBGene00010647; WP:CE35587
K11C4.2 K11C4.2 P W All gene names: K11C4.2; 5H375; CE40569; WBGene00019643; WP:CE40569
K11C4.3 K11C4.3 P W All gene names: bgs-1; unc-70; K11C4.3; 5H371; CE28604; CE30159; WBGene00006803; WP:CE28604; WP:CE30159 WormBase description: unc-70 encodes two isoforms of a beta-spectrin ortholog required for normal body curvature and shape, normal movement, and correct localization of the alpha-spectrin SPC-1; the predominant UNC-70 isoform is expressed in all embryonic cells except the intestine, at the plasma membrane at sites of intercellular contact; UNC-70 becomes largely restricted to muscles and neurons from hatching to adulthood, with expression in adult spermetheca and hypodermis as well; conversely, the minor isoform is predominantly expressed in gut, and is also apposed to intercellular membrane junctions in embryos; sma-1 mutations (which impair the one beta-H-spectrin ortholog in C. elegans) enhance the unc-70 phenotype; UNC-70 is dispensable for viability (under undemanding laboratory culture conditions).
K12B6.4 K12B6.4 P W All gene names: K12B6.4; 5G760; CE12170; WBGene00019669; WP:CE12170
M02B7.3 M02B7.3 P W All gene names: caf-1; klp-2; osm-3; M02B7.3; 4E562; CE31567; CE31568; NM_171308; WBGene00003884; WP:CE31567; WP:CE31568 WormBase description: osm-3 encodes a homolog of the heavy chain subunit of heteromeric anterograde motor kinesins; OSM-3 is required for formation of the distal segment of amphid channel cilia, for responses to osmotic stimuli, for normal dauer formation, and for sensitivity to caffeine.
M03E7.1 M03E7.1 P W All gene names: M03E7.1; 5G103; CE07394; WBGene00019753; WP:CE07394
M28.7 M28.7 P W All gene names: nph-1; nphp-1; M28.7; 2K940; CE16278; NM_063897; WBGene00010898; WP:CE16278 WormBase description: nph-1 encodes a novel, SH3 domain-containing protein that is orthologous to mammalian nephrocystin-1. WormBase CDS description: SH3 domain
R01H10.6 R01H10.6 P W All gene names: bbs-5; R01H10.6; 3L348; CE01042; NM_066871; Q21626_CAEEL; WBGene00010974; WP:CE01042
R05D3.7 R05D3.7 P W All gene names: khc-1; unc-116; R05D3.7; 3J442; CE26945; KINH_CAEEL; NM_066441; WBGene00006840; WP:CE26945 WormBase description: unc-116 encodes a kinesin-1 heavy chain orthologue; UNC-116 is predicted to function as an an anterograde microtubule-based motor and its activity is required for normal early translocation of the meiotic spindle to the oocyte cortex, cortical positioning of the meiosis II spindle, polar body formation, locomotion, and larval development; in regulating meiotic spindle translocation, UNC-116 may function as part of a complex containing the kinesin light chain KLC-2 and a novel cargo adaptor protein, KCA-1. WormBase CDS description: Kinesin heavy chain
R07A4.1 R07A4.1 P W All gene names: egl-36; shw-2; R07A4.1; CE18123; NM_077394; WBGene00001202; WP:CE18123; XL361 WormBase description: egl-36 encodes a shaw voltage-gated potassium channel that affects egg laying and defecation; expressed in the uterine, vulval, anal depressor, sphincter, and four anterior head muscles muscles, and in the AVL and DVB neurons. WormBase CDS description: potassium channel protein
R07B1.1 R07B1.1 P W All gene names: vab-15; R07B1.1; CE01626; MSX1; NM_077247; WBGene00006881; WP:CE01626; XK467 WormBase description: The vab-15 gene encodes a msh-like homeobox gene that appears required for production of touch cell precursors, and that is orthologous to the human gene MSH HOMEO BOX HOMOLOG 1 (MSX1; OMIM:142983) which when mutated leads to disease. WormBase CDS description: homeobox protein (msh subfamily)
R07B5.4 R07B5.4 P W All gene names: sru-38; R07B5.4; 5K316; CE06258; NM_073137; WBGene00005701; WP:CE06258
R08B4.2 R08B4.2 P W All gene names: alr-1; sns-10; R08B4.2; CE03536; WBGene00011138; WBGene00044330; WP:CE03536; XL742 WormBase description: homeobox protein (otd subfamily)
R102.2 R102.2 P W All gene names: R102.2; 4L453; CE23912; WBGene00011289; WP:CE23912
R11G1.4 R11G1.4 P W All gene names: sax-1; R11G1.4; CE39615; CE39616; NM_076226; WBGene00004727; WP:CE39615; WP:CE39616; XE264 WormBase description: The sax-1 gene encodes a homolog of Ndr kinase that regulates neuronal cell shape and neurite initiation.
R13A5.9 R13A5.9 P W All gene names: R13A5.9; 3I666; CE01381; WBGene00020051; WP:CE01381
R13H4.1 R13H4.1 P W All gene names: nph-4; nphp-4; R13H4.1; 5M312; CE38409; NM_073581; WBGene00011261; WP:CE38409
R13H4.5 R13H4.5 P W All gene names: R13H4.5; 5M341; CE12808; WBGene00011263; WP:CE12808 WormBase description: This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins.
R13H7.2 R13H7.2 P W All gene names: SRQ-6; R13H7.2; 4H612; CE39027; CE39028; CE39029; WBGene00020069; WP:CE39027; WP:CE39028; WP:CE39029
T01C3.10 T01C3.10 P W All gene names: nmr-2; T01C3.10; 5P488; CE30445; NM_074293; WBGene00003775; WP:CE30445 WormBase description: glutamate receptor subunit epsilon
T01C4.2 T01C4.2 P W All gene names: odr-2; T01C4.2; 5H593; CE28348; CE28349; CE28350; WBGene00003849; WP:CE28348; WP:CE28349; WP:CE28350 WormBase description: odr-2 encodes three isoforms of a predicted membrane-associated protein related to the Ly-6 (leukocyte antigen-6) family of GPI (glycosylated phosphatidylinositol)-linked signaling proteins; ODR-2 activity is required for proper functioning of the AWC olfactory neurons and thus for chemotaxis in response to AWC-sensed odorants; ODR-2 is expressed at high levels in sensory neurons, motor neurons, and interneurons, where it appears to be enriched in axons.
T01C8.7 T01C8.7 P W All gene names: mec-13; mec-4; T01C8.7; CE39109; NM_078311; WBGene00003168; WP:CE39109; XR418 WormBase description: mec-4 encodes an amiloride-sensitive Na+ channel protein (degenerin) required to sense gentle mechanical stimuli (e.g. touch) along the body wall; MEC-4 is paralogous to, and coexpressed with, MEC-10, in all six touch cell neurons where they form a heteromeric mechanotransduction channel.
T01D3.2 T01D3.2 P W All gene names: T01D3.2; 5O186; CE30446; SIM_CAEEL; WBGene00011327; WP:CE30446 WormBase description: single minded protein
T02C5.5 T02C5.5 P W All gene names: unc-2; T02C5.5; CE29459; CE31225; CE34591; CE34980; NM_171638; NM_171639; NM_171942; WBGene00006742; WP:CE29459; WP:CE31225; WP:CE34591; WP:CE34980; XD330 WormBase description: unc-2 encodes a calcium channel alpha subunit required for desensitization to dopamine, normal flexion and speed during movement, normally low sensitivity of whole animals to serotonin, and neuronal migrations promoted by humoral serotonin; UNC-2 is orthologous to human CACNA1A (OMIM:601011, mutated in familiar hemiplegic migraine or episodic ataxia 2) and to Drosophila CACOPHONY; UNC-2 is expressed primarily in motor neurons, several sensory neurons, and HSN and VC neurons controlling egg-laying.
T05A7.4 T05A7.4 P W All gene names: hmg-11; hmg-I-alpha; T05A7.4; 2E963; CE04890; NM_062424; WBGene00001976; WP:CE04890 WormBase description: nuclear phosphoprotein (weak)
T06H11.1 T06H11.1 P W All gene names: unc-58; T06H11.1; CE31594; CE31595; NM_171758; NM_171759; WBGene00006792; WP:CE31594; WP:CE31595; XK722 WormBase description: unc-58 encodes one of 44 C. elegans TWK (two-P domain K+) potassium channel subunits that contain two pore-forming domains and four transmembrane domains; unc-58 was originally defined by gain-of-function (gf) mutations that result in paralysis and a shortened (dumpy) body morphology due to hypercontraction of body wall muscle; unc-58 gf mutations also result in constitutive egg-laying; as loss of UNC-58 function via reversion or RNA-mediated interference (RNAi) results in either no abnormalities or only a weakly uncoordinated phenotype, UNC-58 likely functions redudantly with other TWK channels to regulate locomotion and egg-laying; UNC-58 is expressed in motor neurons and interneurons.
T12C9.3 T12C9.3 P W All gene names: twk-2; T12C9.3; 2E730; CE39404; NM_062385; NM_077115; WBGene00006657; WP:CE39404 WormBase description: twk-2 encodes one of 44 C. elegans TWK (two-P domain K+) potassium channel subunits that contain two pore-forming domains and four transmembrane domains; the precise role of TWK-2 in C. elegans development and/or behavior is not yet known, but TWK-2 may function redundantly with other TWK channels; TWK-2 is expressed in a subset of neurons.
T12F5.4 T12F5.4 P W All gene names: lin-59; T12F5.4; 1E282; CE13601; NM_058805; WBGene00003040; WP:CE13601
T14A8.1 T14A8.1 P W All gene names: des-5; ric-3; T14A8.1; 4I585; CE27448; NM_068898; WBGene00004363; WP:CE27448 WormBase description: The ric-3 gene encodes a novel, highly charged protein with two transmembrane domains and extensive coiled-coil domains; it is necessary for the function of at least four nicotinic acetylcholine receptors; specifically, it is needed for assembly or trafficking of the DEG-3 nicotinic acetylcholine receptor.
T20H4.1 T20H4.1 P W All gene names: osm-10; T20H4.1; 3I337; CE00750; NM_066197; WBGene00003890; WP:CE00750 WormBase description: osm-10 encodes a novel protein conserved amongst several Caenorhabditis species; osm-10 activity is required for normal osmosensory signaling in the ASH sensory neuron; in regulating ASH-mediated osmosensation, osm-10 interacts genetically with eos-1 and eos-2; OSM-10 is expressed in the ASH, ASI, PHA, and PHB sensory neurons beginning just prior to hatching and continuing through larval and adult stages; OSM-10 localizes to cell bodies, sensory processes, and axons.
T21C12.1 T21C12.1 P W All gene names: unc-49; unc-49A; unc-49B; unc-49C; T21C12.1; 3L621; CE02346; CE28082; CE28083; CE28084; CE28085; CE28086; CE35949; CE40337; CE40338; WBGene00006784; WP:CE02346; WP:CE28082; WP:CE28083; WP:CE28084; WP:CE28085; WP:CE28086; WP:CE35949; WP:CE40337; WP:CE40338 WormBase description: gamma-aminobutyric-acid receptor
T22B7.1 T22B7.1 P W All gene names: cog-2; egl-13; T22B7.1; CE05030; CE28487; CE33702; CE38552; NM_076554; WBGene00001182; WP:CE05030; WP:CE28487; WP:CE33702; WP:CE38552; XG291 WormBase description: egl-13 encodes a transcription factor of the HMG (high mobility group) box family that affects the cell fusion process that makes the vulval-uterine connection and thereby affects egg laying; expressed in the pi lineage cells, transiently expressed in the rho lineage, in the anchor cell following fusion, and in neurons, body wall muscles, and intestinal cells.
T23G5.5 T23G5.5 P W All gene names: dat-1; T23G5.5; 3K335; CE25124; NM_066642; WBGene00000934; WP:CE25124 WormBase description: dat-1 encodes a plasma membrane dopamine transporter; DAT-1 is predicted to regulate dopaminergic neurotransmission via reuptake of dopamine into presynaptic neurons; when expressed in HeLa cells, DAT-1 exhibits high affinity, saturable dopamine transport; further, in primary cultures of C. elegans dopaminergic neurons, DAT-1 also exhibits a channel mode of conduction that leads to membrane depolarization; in hermaphrodites, dat-1 is expressed in the eight dopaminergic neurons (4 CEPs, 2 ADEs, and 2 PDEs), while in males dat-1 is additionally expressed in the three pairs of tail dopaminergic neurons; dat-1 expression begins during embryogenesis with the exception of expression in the PDE neurons which are born postembryonically. WormBase CDS description: sodium:neurotransmitter symporter
T26H10.1 T26H10.1 P W All gene names: acr-4; des-2; T26H10.1; CE21208; NM_073497; WBGene00000955; WP:CE21208 WormBase description: des-2 encodes an alpha subunit of nicotinic acetylcholine receptor (nAChR), predicted to be a ligand-gated ion channel regulating the fast action of acetylcholine at neuromuscular junctions and in the nervous system; DES-2 is coexpressed with and genetically interacts with DEG-3, which which it probably forms heteromultimers, and DES-2 falls into the 'DEG-3' class of nAChR subunits, probably unique to nematodes, which includes DEG-3, ACR-5, ACR-17, ACR-18 ACR-20, and ACR-23. WormBase CDS description: nicotinic acetylcholine receptor
T27A1.6 T27A1.6 P W All gene names: Ce-tbx-12; mab-9; tbx-12; T27A1.6; 2A811; CE24016; NM_061349; WBGene00003106; WP:CE24016 WormBase description: mab-9 encodes a member of the T-box family of transcriptional regulators containing a 200-amino acid T-box DNA-binding domain most similar to mouse Brachyury; mab-9 is involved in hindgut and mail tail development, specifically affecting the fate of two posterior blast cells in the hindgut, B and F; in the male this results in a grossly abnormal tail lacking spicules, and renders them incapable of mating; in the hermaphrodite this results in hindgut defects; mab-9 may also be part of a network of T-box genes that includes tbx-8, tbx-9 and vab-7 and is important for the correct patterning of posterior cells in the developing embryo; mab-9 affects movement to some extent though the basis for this defect is unknown; MAB-9 localizes to the nucleus of B and F and their descendents during development. WormBase CDS description: transcription regulator
T28D9.1 T28D9.1 P W All gene names: T28D9.1; 2G783; CE28092; WBGene00020894; WP:CE28092
W02D3.3 W02D3.3 P W All gene names: mec-6; W02D3.3; 1H303; CE31080; NM_059524; WBGene00003170; WP:CE31080 WormBase description: mec-6 is homologous to the human PARAOXONASE 1 gene (PON1, OMIM:168820), which in some allelic forms is associated with susceptibility to coronary artery disease; MEC-6 protein interacts physically with the MEC-4 degenerin ion channel, is colocalized with it in vivo, and is required for MEC-4 punctate expression along touch-receptor neural processes. WormBase CDS description: paraoxonase/arylesterase
W02D3.9 W02D3.9 P W All gene names: let-76; unc-37; W02D3.9; 1H320; CE14434; ESG; NM_059531; UNC37_CAEEL; WBGene00006773; WP:CE14434 WormBase description: The unc-37 gene encodes a transducin-like WD-repeat protein homologous to Drosophila GROUCHO that genetically interacts with components of the transcriptional Mediator complex. WormBase CDS description: transducin-like enhancer protein
W03A3.1 W03A3.1 P W All gene names: ceh-10; mig-11; W03A3.1; 3G889; CE07563; NM_065850; WBGene00000435; WP:CE07563 WormBase description: ceh-10 encodes a member of the Paired-like class of homeodomain proteins; the CEH-10 homeodomain is closely related to the homeodomains of two vertebrate retina proteins (Chx10 from mice and Vsx-1 from goldfish); ceh-10 is required for CAN cell fate specification and migration, complete loss of ceh-10 function results in failure of CAN cell migration and loss of expression of CEH-23 and CEH-10 itself in the CAN and AIY interneurons; CEH-10, along with TTX-3 and CEH-23, constitutes a regulatory cascade of transcription factors that controls all sub-type specific features of the AIY interneurons.
W05E10.3 W05E10.3 P W All gene names: ceh-32; W05E10.3; 5M182; CE29364; NM_073557; WBGene00000453; WP:CE29364 WormBase description: ceh-32 encodes a Six/sine oculis-type homeodomain protein most closely related to the Six3/6 subfamily that contains Drosophila OPTIX and human SIX3 (OMIM:603714, which when mutated leads to holoprosencephaly 2); CEH-32 appears to be essential for development and required for proper head morphogenesis; during embryogenesis, CEH-32 is expressed in hypodermal and neuronal precursors, and at later stages, in the descendants of these cells and in gonadal sheath cells; in some hypodermal cells, ceh-32 is a direct transcriptional target of VAB-3, a PAX-6 ortholog sufficient to induce ceh-32 expression in some cell types and able to bind the ceh-32 promoter in vitro. WormBase CDS description: homeobox protein (so subfamily)
W10D5.1 W10D5.1 P W All gene names: mef-2; W10D5.1; 1J677; CE25156; NM_060040; WBGene00003182; WP:CE25156 WormBase description: mef-2 encodes a transcription factor that is the sole C. elegans member of the MEF2 subgroup of MADS box transcription factors; loss of mef-2 activity does not result in a strong visible phenotype, although mef-2 mutant adults are slightly dumpy (Dpy); in vitro, MEF-2 is able to bind a consensus MEF2 DNA binding site and interact with the class II histone deacetylase encoded by C10E2.3 (hda-4/hda-7); mef-2 mRNA is detected at all stages of development and expression of mef-2 reporter gene fusions begins in neurons during late embryogenesis and continues in all tissues throughout postembryonic development; mef-2 mutations do not appear to interact with mutations in other myogenic factors such as hlh-1, hlh-8, pha-1, and unc-120. WormBase CDS description: MEF-2 protein
Y16B4A.1 Y16B4A.1 P W All gene names: unc-3; Y16B4A.1; CE29366; NM_078052; WBGene00006743; WP:CE29366; XP401 WormBase description: The unc-3 gene encodes a protein with homology to immunoglobulin (Ig) domain-containing transcription factors such as OLF-1 or SU(H). WormBase CDS description: transcription factor OLF-1 like
Y39B6A.19 Y39B6A.19 P W All gene names: twk-46; Y39B6A.19; Y39B6B.F; 5T541; CE29861; NM_171588; WBGene00006696; WP:CE29861
Y39E4B.8 Y39E4B.8 P W All gene names: zig-8; Y39E4B.8; 3O221; CE24241; NM_067313; WBGene00006985; WP:CE24241
Y40C5A.2 Y40C5A.2 P W All gene names: ocr-4; Y40C5A.2; 4I94; CE40877; NM_068771; WBGene00003841; WP:CE40877 WormBase description: ankyrin-like protein
Y48A6A.1 Y48A6A.1 P W All gene names: zig-5; Y48A6A.1; 3M40; CE31735; NM_067004; WBGene00006982; WP:CE31735 WormBase description: zig-5 encodes a predicted membrane-associated protein containing two C2-type immunoglobulin domains and a GPI (glycosylated phosphatidylinositol) anchor site, but no transmembrane domain; ZIG-5 is predicted to function in cell adhesion and/or signaling, and appears to be required for embryogenesis as well as maintenance of ventral nerve cord organization during larval stages; ZIG-5 is expressed in several different neurons and is detected in the PVT guidepost neuron beginning at the three-fold stage of embryogenesis and continuing throughout larval development.
Y50D7A.6 Y50D7A.6 P W All gene names: klp-20; Y50D7A.6; 3A851; CE26143; NM_064777; WBGene00002230; WP:CE26143; krp85
Y51H4A.17 Y51H4A.17 P W All gene names: sta-1; Y51H4A.17; 4R613; CE35668; CE41061; STAT1_CAEEL; WBGene00013111; WP:CE35668; WP:CE41061 WormBase description: sta-1 encodes the C. elegans STAT orthologue; from N- to C-terminus, STA-1 contains conserved coiled-coil, DNA-binding, and SH2 domains, but apparently lacks a conserved amino-terminal oligomerization domain found in other STAT family members; sta-1 activity is required for repressing dauer formation at high temperatures and genetic analyses indicate that STA-1 acts redundantly with some members of the DAF-7/TGF-beta signaling pathway to repress dauer formation, particularly at low temperatures; tyrosine-phosphorylated STA-1 is able to bind a high affinity mammalian STAT binding sequence, and the STA-1 C-terminus can function as a transcriptional activation domain; sta-1 is widely expressed during most life stages, including the dauer stage, and is found in the pharynx, intestine, body wall muscles, and in neurons; STA-1 localizes to both the cytoplasm and the nucleus, with expression in the latter found particularly in some amphid neurons; in some neurons, STA-1 expression appears to be negatively regulated by DAF-7/TGF-beta signaling.
Y54F10AM.4 Y54F10AM.4 P W All gene names: ceh-44; Y54F10AM.4; 3D635; CE27288; CE32987; CE32988; NM_065174; NM_065175; NM_065176; WBGene00000464; WP:CE27288; WP:CE32987; WP:CE32988 WormBase description: ceh-44 encodes at least three proteins via alternative splicing; the CEH-44A protein is an ortholog of the CUX class of CUT homeodomain proteins, expressed in early embryos (mostly anterior in the comma stage), in the larval nerve ring and the adult gonad; the CUX class includes Drosophila CUT, human CUTL1 and human CUTL2; ceh-44 is a complex gene, in which two alternatively spliced protein products completely lack the homeodomain, and instead resemble vertebrate CASP proteins; CASP proteins are also found in plants and fungi (though not associated with homeodomains); like its orthologs, CEH-44A has three N-terminal cut domains in addition to a C-terminal CUT homeodomain; the cut domain may be a compact DNA-binding domain composed of alpha helices.
Y54G2A.25 Y54G2A.25 P W All gene names: lad-2; Y54G2A.25; Y94H6A_148.D; Y94H6A_148.E; Y94H6A_148.F; 4D730; CE31651; CE34414; CE34415; NM_067875; WBGene00002243; WP:CE31651; WP:CE34414; WP:CE34415 WormBase description: lad-2 encodes a member of the immunoglobulin superfamily that is orthologous to Drosophila Neuroglian and the vertebrate L1-type neural adhesion molecules; although the precise role of LAD-2 in C. elegans development and/or behavior is not yet known, by homology, LAD-2 is predicted to function as an integral membrane receptor that regulates axon guidance and tissue morphogenesis; a lad-2 transcriptional reporter fusion is expressed in the SMD, SAA, SDQ, ALN, and PLN neurons.
Y57G11C.37 Y57G11C.37 P W All gene names: Y57G11C.37; 4P439; CE40485; WBGene00013326; WP:CE40485
ZC196.7 ZC196.7 P W All gene names: glr-5; ZC196.7; 5J199; CE15078; NM_072843; WBGene00001616; WP:CE15078 WormBase description: glr-5 encodes a kainate (non-NMDA)-type ionotropic glutamate receptor subunit; GLR-5 activity is required for normal brood sizes, especially at high temperatures; GLR-5 is expressed in neurons. WormBase CDS description: ligand-gated ionic channel protein
ZC21.2 ZC21.2 P W All gene names: trp-1; ZC21.2; 3J631; CE33009; CE39997; NM_066480; TRPL_CAEEL; WBGene00006614; WP:CE33009; WP:CE39997; strpc1 WormBase description: trp-1 encodes a predicted transmembrane protein with similarity to transient receptor potential (TRP) ion channels; a TRP-1::GFP reporter fusion is expressed in motor neurons, interneurons, vulval and intestinal muscles, and the BAG sensory neuron; as loss of trp-1 activity via deletion mutation or large-scale RNAi results in no obvious defects, the precise role of trp-1 in C. elegans development and/or behavior is not yet known.
ZC247.3 ZC247.3 P W All gene names: lin-11; ZC247.3; 1K831; CE15150; NM_060295; WBGene00003000; WP:CE15150 WormBase description: lin-11 encodes a predicted LIM homeodomain transcription factor that affects vulval development, neuronal development and fate specification, utse cell differentiation, and fertility; it is expressed in some neurons, the vulva, pi cells and their progeny, and the spermatheca. WormBase CDS description: LIM domain containing proteins (2 domains), homeobox protein (lim subfamily)
ZK154.3 ZK154.3 P W All gene names: mec-7; ZK154.3; CE15257; NM_076912; WBGene00003171; WP:CE15257; XI394 WormBase description: mec-7 encodes a beta-tubulin required for touch sensitivity along the body wall, and for normal levels of locomotor activity; it is strongly expressed in six touch receptor neurons, with weak expression in FLP, PVD, and BDU cells. WormBase CDS description: beta tubulin
ZK256.1 ZK256.1 P W All gene names: pmr-1; ZK256.1; 1N615; CE20426; CE27556; CE36258; WBGene00004063; WP:CE20426; WP:CE27556; WP:CE36258; pmr1 WormBase description: The pmr-1 gene encodes a Golgi P-type ATPase Ca^2+/Mn^2+-pump; mutations in its human ortholog, ATP2C1, cause Hailey-Hailey disease (OMIM:169600). WormBase CDS description: E1-E2 ATPase
ZK287.1 ZK287.1 P W All gene names: ZK287.1; 5K149; CE06610; WBGene00013962; WP:CE06610
ZK337.5 ZK337.5 P W All gene names: mtd-1; ZK337.5; 1P599; CE24721; NM_061214; WBGene00003471; WP:CE24721 WormBase description: mtd-1 encodes a novel protein, with an N-terminal extracellular domain and a C-terminal transmembrane domain, that is expressed in touch receptor neurons; loss of mtd-1 function (by either RNAi or a deletion mutation) has no obvious phenotype alone, but specifically enhances touch insensitivity of the temperature-sensitive mec-6(u247).
ZK377.2 ZK377.2 P W All gene names: sax-3; ZK377.2; CE25688; CE31267; NM_171652; WBGene00004729; WP:CE25688; WP:CE31267; XE72 WormBase description: The protein product of sax-3 is homologous to Drosophila ROUNDABOUT; in larval hermaphrodites, SAX-3 is required to confine migrating sex myoblasts to the ventral muscle quadrants during their migration through the body.