Stetina et al 2007, Interactome map of pan-neural , 53 genes
Gene list file name: Stetina2007_figure10
Type of gene identifier: Cosmid name
Description: A comparison to transcripts enriched in both embryonic pan-neural and larval pan-neural datasets revealed a single large interaction cluster
Organism: Caenorhabditis elegans (nematode)
Gene list type: Experimental

Gene name	Source Gene ID	All gene names	WormBase description	WormBase CDS description	Proteome description	Member of lists ()	Other annotations
B0478.1	B0478.1, jnk-1	jnk-1; sak-1; B0478.1; 4H727; CE27574; CE30123; JNK1_CAEEL; NM_171371; WBGene00002178; WP:CE27574; WP:CE30123	jnk-1 encodes a serine/threonine kinase that is the sole C. elegans member of the c-Jun N-terminal kinase (JNK) subgroup of mitogen-activated protein (MAP) kinases; JNK-1 exhibits kinase activity in vitro that is dependent upon activation by the JKK-1 MAPKK; a JNK-1::GFP translational fusion protein is expressed in nearly all neuronal cell bodies and processes, including the nerve ring, head and tail ganglions, and the dorsal and ventral nerve cords, at all stages of development.			
B0547.1	B0547.1	csn-5; B0547.1; 4G415; CE06722; CSN5_CAEEL; NM_068440; WBGene00000817; WP:CE06722	csn-5 encodes an ortholog of subunit 5 of the COP9 signalosome complex (CSN5), which in turn is a pan-eukaryotic multiprotein complex that positively regulates E3 ubiquitin ligases, physically interacts with SCF-type E3 ubiquitin ligases, and probably regulates protein degradation; CSN-5 (along with KGB-1 and ZYX-1) physically binds germline RNA helicases (GLH proteins), and csn-5(RNAi) results in sterile worms with small gonads and no oocytes, causing oogenesis to cease, but not affecting the initial assembly of P granules -- a defect essentially identical to that produced by RNAi with a combination of glh-1 and glh-4.			
C12D8.1	C12D8.1	C12D8.1; 5K718; CE05266; CE05267; CE39222; Q17936_CAEEL; WBGene00007534; WP:CE05266; WP:CE05267; WP:CE39222	C12D8.1 encodes two alternative proteins (through alternative splicing), that belong to an ancient family of single-stranded nucleic acid-binding proteins, and that are predicted to regulate gene expression through binding either mRNA or (locally) single-stranded DNA; they is most likely to specifically bind one or more discrete mRNAs and regulate their spatial localization or alternative splicing.			
C18C4.10	C18C4.10, klc-2	klc-2; C18C4.10; 5G58; CE27362; CE32802; CE32803; CE36917; KLC_CAEEL; WBGene00002215; WP:CE27362; WP:CE32802; WP:CE32803; WP:CE36917	klc-2 encodes a kinesin light chain and was identified as a protein that interacts with UNC-16 by the yeast two-hybrid system, this association suggests that KLC-2 may be involved in the regulation of synaptic vesicle localization by the UNC-16-JNK signaling complex.			
C38D4.6	C38D4.6	ceh-3; nob-2; pal-1; C38D4.6; 3F896; CE05383; CE27837; NM_065590; PAL1_CAEEL; WBGene00003912; WP:CE05383; WP:CE27837	pal-1 encodes a homeodomain protein that is the C. elegans Caudal ortholog; PAL-1 is required maternally and embryonically for cell fate specification and posterior patterning during embryogenesis; PAL-1 is also required postembryonically for fate specification of the posterior V6 neuroectoblast during male tail development; PAL-1 is expressed in posterior blastomeres beginning at the four-cell stage of embryogenesis and its expression continues during embryogenesis in posterior-derived tissues and cells undergoing movement or forming midline structures; pal-1 is subject to both transcriptional and translational regulation.			
K07A9.2	K07A9.2, cmk-1	Ce-CaM-KI; cmk-1; K07A9.2; 4C597; CE25046; NM_067738; Q9TXJ0_CAEEL; WBGene00000553; WP:CE25046	cmk-1 encodes a Ca+2/calmodulin-dependent protein kinase I (CaMK1); CMK-1 activity is required, cell autonomously and downstream of the cyclic nucleotide-gated channel TAX-4, for several aspects of AFD thermosensory neuron differentiation, including expression of the gcy-8 guanylyl cyclase and nhr-38 nuclear hormone receptor genes and morphology of the AFD sensory endings; cmk-1 activity is thus also required for normal thermosensory behavior; a cmk-1::gfp reporter is expressed in head sensory and interneurons as well as in the ventral nerve cord; expression is seen specifically in the neurons of the thermosensory circuit, AFD, AIY, and AIZ; CMK-1 localizes exclusively to the cytoplasm.	ser/thr protein kinase		
F42A6.9	F42A6.9, elks-1	elks-1; F42A6.9; 4E108; CE28392; NM_067928; O44490_CAEEL; WBGene00018330; WP:CE28392	elks-1 encodes the C. elegans homolog of the vertebrate ELKS (glutamine, leucine, lysine, and serine-rich) proteins; although loss of elks-1 activity results in no obvious developmental or behavioral abnormalities, the ELKS-1 C-terminus interacts with the PDZ domain of UNC-10/RIM in vitro, and in vivo each protein appears to play a nonessential role in localizing the other to the presynaptic active zone; in addition to the active zone, ELKS-1 also localizes to the pharyngeal basal lamina.			
F01G4.1	F01G4.1, psa-4	psa-4; F01G4.1; 4L895; CE05553; NM_069681; WBGene00004204; WP:CE05553	The psa-4 (phasmid socket absent) gene encodes an ortholog of SWI2/SNF2, a component of the SWI/SNF complex that is conserved from yeast to mammals and that is involved in chromatin remodeling; psa-4 is probably required during mitosis of the T cells for asymmetric cell division.	SNF2alpha like		
F13B9.5	F13B9.5, ksr-1	ksr-1; sar-2; sur-3; F13B9.5; CE25854; NM_076995; WBGene00002239; WP:CE25854; XI901				
F14F3.1	F14F3.1, vab-3	lin-20; mab-18; pax-6; vab-3; F14F3.1; CE24899; CE28216; CE28217; Q17359_CAEEL; WBGene00006870; WP:CE24899; WP:CE28216; WP:CE28217; XL137	vab-3 encodes a homeodomain protein that is the C. elegans Pax-6 orthologue; during development, vab-3 activity is required for proper patterning of anterior (head) hypodermal cells; vab-3 effects head development, in part, through positively regulating transcription of ceh-32, a Six/sine oculis class homeobox gene coexpressed with vab-3 in head hypodermis.			
F35C8.3	F35C8.3, jkk-1	jkk-1; sek-2; F35C8.3; CE24941; NM_076512; Q9UAH1_CAEEL; WBGene00002177; WP:CE24941; XF989	jkk-1 encodes a member of the MAP kinase kinase superfamily that affects synaptic vesicle localization and is required in type-D motor neurons for normal locomotion; can function in the Hog1 MAP kinase pathway I in yeast as an activator of JNK and is expressed in most neurons			
F42A6.9	F42A6.9, elks-1	elks-1; F42A6.9; 4E108; CE28392; NM_067928; O44490_CAEEL; WBGene00018330; WP:CE28392	elks-1 encodes the C. elegans homolog of the vertebrate ELKS (glutamine, leucine, lysine, and serine-rich) proteins; although loss of elks-1 activity results in no obvious developmental or behavioral abnormalities, the ELKS-1 C-terminus interacts with the PDZ domain of UNC-10/RIM in vitro, and in vivo each protein appears to play a nonessential role in localizing the other to the presynaptic active zone; in addition to the active zone, ELKS-1 also localizes to the pharyngeal basal lamina.			
F42G10.2	F42G10.2, mkk-4	mkk-4; F42G10.2; CE10328; NM_077281; WBGene00003368; WP:CE10328; XK651; YR62_CAEEL	mkk-4 encodes a MAP (mitogen-activated protein) kinase kinase that is a member of the MKK4 family of MAPKK's; MKK-4 activity is required in presynaptic neurons, in a dose-dependent manner, for normal presynaptic development and morphology; in regulating presynaptic organization, MKK-4 acts upstream of PMK-3/MAPK and downstream of DLK-1/MAPKKK, whose levels are negatively regulated by the RPM-1 ubiquitin ligase; a functional MKK-4::GFP fusion protein is expressed in the cytoplasm of many neurons as well as in other cell types, including the pharyngeal muscles.	serine/threonine kinase		
F43C1.2	F43C1.2, mpk-1	mpk-1; sur-1; F43C1.2; 3F308; CE01583; CE24971; SUR1_CAEEL; WBGene00003401; WP:CE01583; WP:CE24971	mpk-1 encodes a mitogen-activated protein (MAP) kinase that acts in the vulval precursor cells to affect LET-60(Ras)-mediated induction of vulval cell fates, and also affects larval viability, morphology of the male spicules, and acts in combination with mek-2 to permit germ cell exit from the pachytene stage of first meiotic prophase; both LIN-1 and LIN-31 act genetically downstream of mpk-1 with respect to vulval induction, and LIN-1 and LIN-31 are substrates for MPK-1 in vitro.	serine/threonine kinase (CDC2/CDC28 subfamily)		
F43G6.8	F43G6.8	F43G6.8; 2M102; CE20789; Q20369_CAEEL; WBGene00009660; WP:CE20789	Zinc finger, C3HC4 type (RING finger)			
F44G3.9	F44G3.9	nhr-111; F44G3.9; 5Q604; CE35538; NH111_CAEEL; NM_074659; WBGene00003701; WP:CE35538	nhr-111 encodes a member of the nuclear receptor superfamily; by homology, NHR-111 is predicted to function as a ligand-dependent transcriptional regulator, but as loss of nhr-111 activity via large-scale RNAi screens does not result in any abnormalities, the precise role of NHR-111 in C. elegans development and/or behavior is not yet known; an nhr-111 reporter construct is expressed in embryos and early larvae in a pair of neurons in the ventral ganglion of the head and in two cells that may be the somatic gonad precursors.	Zinc finger, C4 type (two domains)		
F46G11.1	F46G11.1	F46G11.1; CE37646; WBGene00018514; WP:CE37646; XG415	F46G11.1 is orthologous to the human gene TRUNCATED PUTATIVE T7-LIKE MITOCHONDRIAL DNA HELICASE (C10orf2; OMIM:606075), which when mutated leads to disease.			
F49H12.3	F49H12.3	F49H12.3; CE20837; Q9N5S5_CAEEL; WBGene00018654; WP:CE20837; XC703				
F53G12.10	F53G12.10, rpl-7	rpl-7; F53G12.10; 1A583; CE11024; NM_058275; RL7_CAEEL; WBGene00004418; WP:CE11024	rpl-7 encodes a large ribosomal subunit L7 protein required in mass RNAi assays for embryonic viability and normally rapid growth.	ribosomal protein		
F59A6.1	F59A6.1, nsy-1	ask-1; esp-8; nsy-1; F59A6.1; 2F319; CE33405; NM_062524; Q21029_CAEEL; WBGene00003822; WP:CE33405	nsy-1 encodes a MAP kinase kinase kinase homolog that affects chemotaxis, egg laying, and pathogen response; NSY-1 activity is activated by the calmodulin kinase UNC-43, and is required for lateral signalling that leads to asymmetric olfactory neuron fates; interacts with SEK-1, and is expressed in the intestine, hypodermis, rectal gland cells, and neurons.	Protein kinase		
W07B3.2	W07B3.2, gei-4	gei-4; W07B3.2; 3A962; CE17290; CE17291; CE32743; CE34603; CE34604; CE37419; NM_064787; NM_064788; NM_064789; NM_181925; Q9TZ38_CAEEL; WBGene00001561; WP:CE17290; WP:CE17291; WP:CE32743; WP:CE34603; WP:CE34604; WP:CE37419	gei-4 encodes a protein with a coiled-coil domain (predicted to mediate protein-protein interactions), an internal repeat of 69 residues (covering residues 134-202, 203-265, and 266-328 of W07B3.2a), and a glutamine/asparagine-rich domain; GEI-4 is paralogous to Y50D7A.8 and Y59C2A.3, physically interacts with GEX-2, and is required for embryonic viability, fertility, and vulval morphogenesis; GEI-4 is claimed to have weak homology to trichohyalin, a mammalian intermediate filament interacting protein; the similarity of the mutant phenotypes of gei-4, gex-2 and gex-3 and their interaction sugggest that the GEX-2/GEX-3/GEI-4 protein complex is essential for the regulation of intermediate filaments during rearrangement of the cytoskeleton that occurs in embryogenesis; GFI-2, an ankyrin-repeat protein associates with GEI-4 and exhibits a similar mutant phenotype, suggesting that gfi-2 is also involved in intermediate filament dynamics.			
H06I04.1	H06I04.1	H06I04.1; 3E189; CE29971; CE31020; CE31021; Q9N5N7_CAEEL; WBGene00019167; WP:CE29971; WP:CE31020; WP:CE31021				
F35C8.3	F35C8.3, jkk-1	jkk-1; sek-2; F35C8.3; CE24941; NM_076512; Q9UAH1_CAEEL; WBGene00002177; WP:CE24941; XF989	jkk-1 encodes a member of the MAP kinase kinase superfamily that affects synaptic vesicle localization and is required in type-D motor neurons for normal locomotion; can function in the Hog1 MAP kinase pathway I in yeast as an activator of JNK and is expressed in most neurons			
B0478.1	B0478.1, jnk-1	jnk-1; sak-1; B0478.1; 4H727; CE27574; CE30123; JNK1_CAEEL; NM_171371; WBGene00002178; WP:CE27574; WP:CE30123	jnk-1 encodes a serine/threonine kinase that is the sole C. elegans member of the c-Jun N-terminal kinase (JNK) subgroup of mitogen-activated protein (MAP) kinases; JNK-1 exhibits kinase activity in vitro that is dependent upon activation by the JKK-1 MAPKK; a JNK-1::GFP translational fusion protein is expressed in nearly all neuronal cell bodies and processes, including the nerve ring, head and tail ganglions, and the dorsal and ventral nerve cords, at all stages of development.			
K07A9.2	K07A9.2, cmk-1	Ce-CaM-KI; cmk-1; K07A9.2; 4C597; CE25046; NM_067738; Q9TXJ0_CAEEL; WBGene00000553; WP:CE25046	cmk-1 encodes a Ca+2/calmodulin-dependent protein kinase I (CaMK1); CMK-1 activity is required, cell autonomously and downstream of the cyclic nucleotide-gated channel TAX-4, for several aspects of AFD thermosensory neuron differentiation, including expression of the gcy-8 guanylyl cyclase and nhr-38 nuclear hormone receptor genes and morphology of the AFD sensory endings; cmk-1 activity is thus also required for normal thermosensory behavior; a cmk-1::gfp reporter is expressed in head sensory and interneurons as well as in the ventral nerve cord; expression is seen specifically in the neurons of the thermosensory circuit, AFD, AIY, and AIZ; CMK-1 localizes exclusively to the cytoplasm.	ser/thr protein kinase		
K11E8.1	K11E8.1, unc-43	dec-8; unc-43; K11E8.1; 4L90; CE28051; CE28052; CE28053; CE28054; CE28055; CE28056; CE28057; CE28058; CE28059; CE28060; CE28061; CE35590; CE40979; O62305_CAEEL; Q21431_CAEEL; WBGene00006779; WP:CE28051; WP:CE28052; WP:CE28053; WP:CE28054; WP:CE28055; WP:CE28056; WP:CE28057; WP:CE28058; WP:CE28059; WP:CE28060; WP:CE28061; WP:CE35590; WP:CE40979	unc-43(gf) mutants (in which unc-43 is overexpressed) suppress the excess motoneuron branching, and thus the uncoordinated phenotype, induced by an unc-6deltaC transgene.	Ca2+/calmodulin-dependent protein kinase		
C18C4.10	C18C4.10, klc-2	klc-2; C18C4.10; 5G58; CE27362; CE32802; CE32803; CE36917; KLC_CAEEL; WBGene00002215; WP:CE27362; WP:CE32802; WP:CE32803; WP:CE36917	klc-2 encodes a kinesin light chain and was identified as a protein that interacts with UNC-16 by the yeast two-hybrid system, this association suggests that KLC-2 may be involved in the regulation of synaptic vesicle localization by the UNC-16-JNK signaling complex.			
F13B9.5	F13B9.5, ksr-1	ksr-1; sar-2; sur-3; F13B9.5; CE25854; NM_076995; WBGene00002239; WP:CE25854; XI901				
ZC8.4	ZC8.4, lfi-1	lfi-1; ZC8.4; CE31264; CE35814; CE38922; CE38923; NM_076446; NM_076447; Q23081_CAEEL; WBGene00022500; WP:CE31264; WP:CE35814; WP:CE38922; WP:CE38923; XF611	lfi-1 encodes a coiled-coil protein that is similar to the Parascaris univalens Mitotic Antigen, PUMA1; LFI-1 was initially identified in yeast two-hybrid screens for proteins that interact with the coiled-coil protein LIN-5, which is essential for proper spindle positioning and chromosome segregation; antibody staining reveals that, in embryos, LFI-1 is expressed in metaphase cells in a diffuse area surrounding the kinetochore microtubules and overlapping with LIN-5 localization; in interphase cells, LFI-1 localizes to the nucleus and remains in the nuclear region even after nuclear envelope breakdown; as loss of lfi-1 activity, or the combined activities of lfi-1 and a related gene, F35D11.11, by RNAi results in no obvious defects, the precise role of LFI-1 in development is not yet known.			
F42G10.2	F42G10.2, mkk-4	mkk-4; F42G10.2; CE10328; NM_077281; WBGene00003368; WP:CE10328; XK651; YR62_CAEEL	mkk-4 encodes a MAP (mitogen-activated protein) kinase kinase that is a member of the MKK4 family of MAPKK's; MKK-4 activity is required in presynaptic neurons, in a dose-dependent manner, for normal presynaptic development and morphology; in regulating presynaptic organization, MKK-4 acts upstream of PMK-3/MAPK and downstream of DLK-1/MAPKKK, whose levels are negatively regulated by the RPM-1 ubiquitin ligase; a functional MKK-4::GFP fusion protein is expressed in the cytoplasm of many neurons as well as in other cell types, including the pharyngeal muscles.	serine/threonine kinase		
F43C1.2	F43C1.2, mpk-1	mpk-1; sur-1; F43C1.2; 3F308; CE01583; CE24971; SUR1_CAEEL; WBGene00003401; WP:CE01583; WP:CE24971	mpk-1 encodes a mitogen-activated protein (MAP) kinase that acts in the vulval precursor cells to affect LET-60(Ras)-mediated induction of vulval cell fates, and also affects larval viability, morphology of the male spicules, and acts in combination with mek-2 to permit germ cell exit from the pachytene stage of first meiotic prophase; both LIN-1 and LIN-31 act genetically downstream of mpk-1 with respect to vulval induction, and LIN-1 and LIN-31 are substrates for MPK-1 in vitro.	serine/threonine kinase (CDC2/CDC28 subfamily)		
F59A6.1	F59A6.1, nsy-1	ask-1; esp-8; nsy-1; F59A6.1; 2F319; CE33405; NM_062524; Q21029_CAEEL; WBGene00003822; WP:CE33405	nsy-1 encodes a MAP kinase kinase kinase homolog that affects chemotaxis, egg laying, and pathogen response; NSY-1 activity is activated by the calmodulin kinase UNC-43, and is required for lateral signalling that leads to asymmetric olfactory neuron fates; interacts with SEK-1, and is expressed in the intestine, hypodermis, rectal gland cells, and neurons.	Protein kinase		
F39D8.2	psa-3	psa-3; F39D8.2; CE40386; CE40387; WBGene00009560; WP:CE40386; WP:CE40387; XQ37				
F01G4.1	F01G4.1, psa-4	psa-4; F01G4.1; 4L895; CE05553; NM_069681; WBGene00004204; WP:CE05553	The psa-4 (phasmid socket absent) gene encodes an ortholog of SWI2/SNF2, a component of the SWI/SNF complex that is conserved from yeast to mammals and that is involved in chromatin remodeling; psa-4 is probably required during mitosis of the T cells for asymmetric cell division.	SNF2alpha like		
R03G5.2	R03G5.2, sek-1	esp-2; sek-1; R03G5.2; CE31210; NM_076921; Q95YI9_CAEEL; WBGene00004758; WP:CE31210; XI439	SEK-1 has MAPKK activity and belongs to the MAPKK family; SEK-1 can activate both JNK-1 and PMK-1 in the yeast Hog pathway.	SER/THR-protein kinase		
R07E5.3	R07E5.3	R07E5.3; 3F495; CE01045; Q21831_CAEEL; WBGene00011111; WP:CE01045	The R07E5.3 gene encodes a homolog of SNF5/Ini1, a component of the SWI/SNF complex that is conserved from yeast to mammals and that is involved in chromatin remodeling; R07E5.3 may be involved in asymmetric cell division of the T cells.	Snf5 (yeast)		
F53G12.10	F53G12.10, rpl-7	rpl-7; F53G12.10; 1A583; CE11024; NM_058275; RL7_CAEEL; WBGene00004418; WP:CE11024	rpl-7 encodes a large ribosomal subunit L7 protein required in mass RNAi assays for embryonic viability and normally rapid growth.	ribosomal protein		
R03G5.2	R03G5.2, sek-1	esp-2; sek-1; R03G5.2; CE31210; NM_076921; Q95YI9_CAEEL; WBGene00004758; WP:CE31210; XI439	SEK-1 has MAPKK activity and belongs to the MAPKK family; SEK-1 can activate both JNK-1 and PMK-1 in the yeast Hog pathway.	SER/THR-protein kinase		
Y46G5A.30	snf-5	snf-5; Y46G5A.30; 2N152; CE29609; NM_064334; WBGene00004904; WP:CE29609				
T05C12.6	T05C12.6	mig-5; T05C12.6; 2I474; CE02318; CE25100; CE28076; Q22227_CAEEL; WBGene00003241; WP:CE02318; WP:CE25100; WP:CE28076	mig-5 encodes one of three C. elegans Dishevelled homologs; as part of both canonical and non-canonical Wnt signaling pathways, mig-5 activity is required maternally and embryonically for cell migration, cell fate specification, and proper spindle orientation in the early embryo; cells affected by mig-5 mutations include the distal tip cells (DTCs), the QL neuroblast descendants (QL.d), the vulval precursor cells, and the P12 ectoblast; in the early embryo, MIG-5 functions downstream of MOM-2/Wnt and MOM-1/Porc, and redundantly with two other Dishevelled homologs, DSH-1 and DSH-2, in a non-canonical Wnt pathway that specifies the endoderm cell fate and regulates mitotic spindle orientation in the EMS and ABar blastomeres; in posteriorly directed QL.d migrations, MIG-5 functions downstream of EGL-20/Wnt and upstream of PRY-1/Axin in a canonical Wnt pathway to positively regulate Wnt signaling and effect MAB-5 expression in QL.d; a mig-5::GFP fusion is reportedly expressed in many cells in the embryo, migrating DTCs, P cells, and the nerve ring.	presynaptic density protein (PSD-95) repeat-like domain		
T17H7.4	T17H7.4	gei-16; T17H7.4; 3B346; CE28670; CE28671; CE28672; CE31612; CE31613; CE31614; CE31615; CE31616; CE31617; CE31618; CE33939; CE35016; NM_064843; NM_064844; NM_064845; NM_064846; NM_064847; NM_171067; NM_171068; NM_171069; NM_171070; NM_171071; NM_171859; Q22534_CAEEL; WBGene00001573; WP:CE28670; WP:CE28671; WP:CE28672; WP:CE31612; WP:CE31613; WP:CE31614; WP:CE31615; WP:CE31616; WP:CE31617; WP:CE31618; WP:CE33939; WP:CE35016	gei-16 can encode a protein with similarity to the B20 antigen of the parasitic nematode Onchocerca volvulus; GEI-16 is required for ventral enclosure and elongation during embryonic development, larval development, and normal rates of postembryonic growth; GEI-16 interacts with GEX-3, a homolog of mammalian protein ligands of the small GTPase Rac1 that is also essential for embryonic morphogenesis.			
T21H3.3	T21H3.3	cmd-1; T21H3.3; 5B635; CALM_CAEEL; CE13902; NM_070985; WBGene00000552; WP:CE13902	cmd-1 encodes a putative homolog of calmodulin 1 that affects growth rate and fertility.	calmodulin		
T22H2.5	T22H2.5	plsc-2; scrm-1; T22H2.5; 1M282; CE36204; CE36205; O45799_CAEEL; WBGene00011935; WP:CE36204; WP:CE36205	T22H2.5 encodes a homolog of human scramblase (PLSCR1; OMIM:604170), which is activated by a rise of intracellular calcium, and which promotes the exposure of phosphatidylserine on the surface of cells undergoing activation, injury, or apoptosis; closely related paralogs of T22H2.5 include C04E12.7 and ZK1053.5.			
ZK1098.10	ZK1098.10, unc-16	egl-39; unc-16; ZK1098.10; 3K645; CE00363; CE31846; JIP_CAEEL; NM_171221; WBGene00006755; WP:CE00363; WP:CE31846	unc-16 encodes a homolog of murine JIP3/JSAP and Drosophila SUNDAY DRIVER that is involved in vesicle transport, and that affects egg laying, locomotion, and defecation and physically interacts with JNK and JNK kinases; UNC-16 is expressed in neurons of the ventral cord, retrovesicular and preanal ganglia, the nerve ring, intestinal cells, seam and hypodermal cells, body wall and head muscle, and pharynx.			
K11E8.1	K11E8.1, unc-43	dec-8; unc-43; K11E8.1; 4L90; CE28051; CE28052; CE28053; CE28054; CE28055; CE28056; CE28057; CE28058; CE28059; CE28060; CE28061; CE35590; CE40979; O62305_CAEEL; Q21431_CAEEL; WBGene00006779; WP:CE28051; WP:CE28052; WP:CE28053; WP:CE28054; WP:CE28055; WP:CE28056; WP:CE28057; WP:CE28058; WP:CE28059; WP:CE28060; WP:CE28061; WP:CE35590; WP:CE40979	unc-43(gf) mutants (in which unc-43 is overexpressed) suppress the excess motoneuron branching, and thus the uncoordinated phenotype, induced by an unc-6deltaC transgene.	Ca2+/calmodulin-dependent protein kinase		
F14F3.1	F14F3.1, vab-3	lin-20; mab-18; pax-6; vab-3; F14F3.1; CE24899; CE28216; CE28217; Q17359_CAEEL; WBGene00006870; WP:CE24899; WP:CE28216; WP:CE28217; XL137	vab-3 encodes a homeodomain protein that is the C. elegans Pax-6 orthologue; during development, vab-3 activity is required for proper patterning of anterior (head) hypodermal cells; vab-3 effects head development, in part, through positively regulating transcription of ceh-32, a Six/sine oculis class homeobox gene coexpressed with vab-3 in head hypodermis.			
W07B3.2	W07B3.2, gei-4	gei-4; W07B3.2; 3A962; CE17290; CE17291; CE32743; CE34603; CE34604; CE37419; NM_064787; NM_064788; NM_064789; NM_181925; Q9TZ38_CAEEL; WBGene00001561; WP:CE17290; WP:CE17291; WP:CE32743; WP:CE34603; WP:CE34604; WP:CE37419	gei-4 encodes a protein with a coiled-coil domain (predicted to mediate protein-protein interactions), an internal repeat of 69 residues (covering residues 134-202, 203-265, and 266-328 of W07B3.2a), and a glutamine/asparagine-rich domain; GEI-4 is paralogous to Y50D7A.8 and Y59C2A.3, physically interacts with GEX-2, and is required for embryonic viability, fertility, and vulval morphogenesis; GEI-4 is claimed to have weak homology to trichohyalin, a mammalian intermediate filament interacting protein; the similarity of the mutant phenotypes of gei-4, gex-2 and gex-3 and their interaction sugggest that the GEX-2/GEX-3/GEI-4 protein complex is essential for the regulation of intermediate filaments during rearrangement of the cytoskeleton that occurs in embryogenesis; GFI-2, an ankyrin-repeat protein associates with GEI-4 and exhibits a similar mutant phenotype, suggesting that gfi-2 is also involved in intermediate filament dynamics.			
Y113G7B.23	Y113G7B.23	psa-1; Y113G7B.23; 5U710; CE25208; NM_075505; Q9U2W6_CAEEL; WBGene00004203; WP:CE25208	psa-1 encodes an ortholog of SWI3, a component of the SWI/SNF complex that is conserved from yeast to mammals and that is involved in chromatin remodeling; psa-1 is probably required during mitosis of the T cells for asymmetric cell division, and in addition, is required for embryonic and larval development, as well as normal levels of fertility; psa-1 exhibits strong genetic interactions with lin-35/Rb, as psa-1 larval lethality and sterility at 20 degrees C are greatly enhanced in lin-35;psa-1 double mutants.	SWI/SNF protein		
Y51H4A.17	Y51H4A.17	sta-1; Y51H4A.17; 4R613; CE35668; CE41061; STAT1_CAEEL; WBGene00013111; WP:CE35668; WP:CE41061	sta-1 encodes the C. elegans STAT orthologue; from N- to C-terminus, STA-1 contains conserved coiled-coil, DNA-binding, and SH2 domains, but apparently lacks a conserved amino-terminal oligomerization domain found in other STAT family members; sta-1 activity is required for repressing dauer formation at high temperatures and genetic analyses indicate that STA-1 acts redundantly with some members of the DAF-7/TGF-beta signaling pathway to repress dauer formation, particularly at low temperatures; tyrosine-phosphorylated STA-1 is able to bind a high affinity mammalian STAT binding sequence, and the STA-1 C-terminus can function as a transcriptional activation domain; sta-1 is widely expressed during most life stages, including the dauer stage, and is found in the pharynx, intestine, body wall muscles, and in neurons; STA-1 localizes to both the cytoplasm and the nucleus, with expression in the latter found particularly in some amphid neurons; in some neurons, STA-1 expression appears to be negatively regulated by DAF-7/TGF-beta signaling.			
Y54E10BL.6	Y54E10BL.6	glv-1; let-537; mek-2; Y54E10BL.6; Y54E10B_152.C; 1D574; CE25437; NM_058686; WBGene00003186; WP:CE25437	protein kinase			
ZC8.4	ZC8.4, lfi-1	lfi-1; ZC8.4; CE31264; CE35814; CE38922; CE38923; NM_076446; NM_076447; Q23081_CAEEL; WBGene00022500; WP:CE31264; WP:CE35814; WP:CE38922; WP:CE38923; XF611	lfi-1 encodes a coiled-coil protein that is similar to the Parascaris univalens Mitotic Antigen, PUMA1; LFI-1 was initially identified in yeast two-hybrid screens for proteins that interact with the coiled-coil protein LIN-5, which is essential for proper spindle positioning and chromosome segregation; antibody staining reveals that, in embryos, LFI-1 is expressed in metaphase cells in a diffuse area surrounding the kinetochore microtubules and overlapping with LIN-5 localization; in interphase cells, LFI-1 localizes to the nucleus and remains in the nuclear region even after nuclear envelope breakdown; as loss of lfi-1 activity, or the combined activities of lfi-1 and a related gene, F35D11.11, by RNAi results in no obvious defects, the precise role of LFI-1 in development is not yet known.			
ZK1098.10	ZK1098.10, unc-16	egl-39; unc-16; ZK1098.10; 3K645; CE00363; CE31846; JIP_CAEEL; NM_171221; WBGene00006755; WP:CE00363; WP:CE31846	unc-16 encodes a homolog of murine JIP3/JSAP and Drosophila SUNDAY DRIVER that is involved in vesicle transport, and that affects egg laying, locomotion, and defecation and physically interacts with JNK and JNK kinases; UNC-16 is expressed in neurons of the ventral cord, retrovesicular and preanal ganglia, the nerve ring, intestinal cells, seam and hypodermal cells, body wall and head muscle, and pharynx.			
ZK849.2	ZK849.2	ZK849.2; CE40678; CE40679; CE41095; O18302_CAEEL; WBGene00014101; WP:CE40678; WP:CE40679; WP:CE41095	PDZ domain (Also known as DHR or GLGF).