|Gene list file name:||Stetina2007_table4|
|Type of gene identifier:||MA primer pair (sjj)|
|Description:||Genes expressed in mechanosensory neurons are differentially detected in the larval pan-neural dataset versus the larval A-class dataset, This data shows the difference in the expression of these genes|
|Organism:||Caenorhabditis elegans (nematode)|
|Gene list type:||Experimental|
Gene name Source Gene ID Annotation Date Added by
C44B11.3 C44B11.3 P W All gene names: Alpha-tubulin; mec-12; tba-3; C44B11.3; 3E222; CE24843; NM_065262; WBGene00003175; WP:CE24843 WormBase description: mec-12 encodes a novel C. elegans alpha-tubulin that is unique amongst C. elegans alpha tubulins in that it may be subject to post-translational acetylation; MEC-12 is required for normal mechanosensory response to gentle touch, and specifically for formation of the 15-protofilament microtubule bundle present in the touch receptor neurons; mec-12 interacts genetically with mec-5, which encodes a unique C. elegans collagen secreted by the hypodermis; MEC-12 is highly expressed in the touch neurons as well as in several other neurons that do not contains the microfilament bundle, such as the ventral cord motorneurons. WormBase CDS description: alpha tubulin
C52B9.9 C52B9.9 P W All gene names: mec-18; C52B9.9; CE16940; NM_076330; WBGene00003179; WP:CE16940; XE890 WormBase description: mec-18 encodes a protein similar to firefly luciferase and plant protein 4-coumarate coA ligase; mec-18 is involved in sensory mechanotransduction; genetic interactions with other mec genes suggest that mec-18 maybe involved in negative regulation of the degenerin channel in the touch receptor neurons; mec-18 is expressed exclusively in the touch cells. WormBase CDS description: AMP-binding protein
F01D4.6 F01D4.6 P W All gene names: mec-3; F01D4.6; 4L224; CE27422; CE34792; NM_069530; WBGene00003167; WP:CE27422; WP:CE34792 WormBase description: mec-3 encodes a founding member of the LIM (Lin-11, Isl-1, Mec-3) homeodomain family of transcriptional regulators; during C. elegans development, MEC-3 activity is required for proper differentiation and maturation of the mechanosensory neurons; MEC-3 is expressed in the mechanosensory neurons, where initiation of expression is dependent upon the UNC-86 homeodomain protein and maintenance of expression is dependent upon MEC-3 itself and mec-17.
F14D12.4 F14D12.4 P W All gene names: mec-2; F14D12.4; CE04393; CE30952; CE37633; NM_171691; WBGene00003166; WP:CE04393; WP:CE30952; WP:CE37633; XG209 WormBase description: The mec-2 gene encodes a stomatin homolog required to sense gentle mechanical stimuli (e.g. touch) along the body wall.
F16F9.5 F16F9.5 P W All gene names: deg-2; mec-10; F16F9.5; CE09444; NM_077037; WBGene00003174; WP:CE09444; XJ86 WormBase description: The mec-10 gene encodes an amiloride-sensitive Na+ channel protein (degenerin) required to sense gentle mechanical stimuli (e.g. touch) along the body wall; it is paralogous to mec-4, which has similar function in vivo. WormBase CDS description: degenerin
F57H12.7 F57H12.7 P W All gene names: mec-17; F57H12.7; 4I750; CE17128; NM_068936; WBGene00003178; WP:CE17128 WormBase description: mec-17 encodes a protein that has no clearly recognizable motifs yet shares a domain of similarity with an additional C. elegans protein as well as proteins from Drosophila, mouse, and human; MEC-17 activity is required for maintaining the differentiated state of the touch receptors, and hence the animal's touch sensitivity, during later stages of larval development; mec-17 is expressed solely in the touch receptor cells from late embryogenesis through adulthood, and this expression is dependent upon the MEC-3 LIM homeodomain transcription factor; in turn, as MEC-17 is necessary for maintaining differentiated touch receptors, its activity is required for continued expression of MEC-3 and the MEC-7 beta-tubulin.
T01C8.7 T01C8.7 P W All gene names: mec-13; mec-4; T01C8.7; CE39109; NM_078311; WBGene00003168; WP:CE39109; XR418 WormBase description: mec-4 encodes an amiloride-sensitive Na+ channel protein (degenerin) required to sense gentle mechanical stimuli (e.g. touch) along the body wall; MEC-4 is paralogous to, and coexpressed with, MEC-10, in all six touch cell neurons where they form a heteromeric mechanotransduction channel.
W02D3.3 W02D3.3 P W All gene names: mec-6; W02D3.3; 1H303; CE31080; NM_059524; WBGene00003170; WP:CE31080 WormBase description: mec-6 is homologous to the human PARAOXONASE 1 gene (PON1, OMIM:168820), which in some allelic forms is associated with susceptibility to coronary artery disease; MEC-6 protein interacts physically with the MEC-4 degenerin ion channel, is colocalized with it in vivo, and is required for MEC-4 punctate expression along touch-receptor neural processes. WormBase CDS description: paraoxonase/arylesterase
ZK154.3 ZK154.3 P W All gene names: mec-7; ZK154.3; CE15257; NM_076912; WBGene00003171; WP:CE15257; XI394 WormBase description: mec-7 encodes a beta-tubulin required for touch sensitivity along the body wall, and for normal levels of locomotor activity; it is strongly expressed in six touch receptor neurons, with weak expression in FLP, PVD, and BDU cells. WormBase CDS description: beta tubulin