Stetina et al 2007, SMAD receptors, 3 genes

Gene list file name:Stetina2007_table3SMAD
Type of gene identifier:MA primer pair (sjj)
Description:Major transcription factor families enriched in C. elegans neurons SMAD receptor group  
Organism:Caenorhabditis elegans (nematode)
Gene list type:Experimental

Gene name             Source Gene ID          Annotation                                                  Date       Added by    

F01G10.8 F01G10.8 P W All gene names: daf-14; F01G10.8; 4L19; CE29090; NM_069479; WBGene00000910; WP:CE29090 WormBase description: daf-14 encodes a Smad-related protein that is unusual in that while its C-terminus is well-conserved with Smad proteins, it lacks the N-terminal DNA binding domain found in all other known Smads; DAF-14 is predicted to function as a transducer of the DAF-7/TGF-beta-mediated signal that promotes reproductive growth and negatively regulates dauer formation; as reduction of daf-14 function enhances the dauer constitutive phenotype of daf-8 mutants, and overexpression of daf-14 can rescue daf-8 mutant animals, it is likely that the DAF-14 and DAF-8 Smad proteins function in parallel to control dauer formation; further genetic analyses suggest that DAF-14 and DAF-8 function to antagonize the activities of the DAF-3 Smad and DAF-5 Sno/Ski oncoprotein, which are required for dauer formation; a DAF-14::GFP reporter is expressed in a dynamic pattern in tissues, such as the hypodermis, intestine, and pharynx, that are remodeled during dauer development. WormBase CDS description: Mouse MSMAD protein like
F25E2.5 F25E2.5 P W All gene names: daf-3; F25E2.5; CE26364; CE28002; CE30963; NM_075760; Q95QI7_CAEEL; WBGene00000899; WP:CE26364; WP:CE28002; WP:CE30963; XB438 WormBase description: daf-3 encodes a Smad protein; DAF-3 functions as a transcriptional regulator that is required for formation of the alternative dauer larval stage; DAF-3 activity is antagonized by signaling through the DAF-7/TGF-beta pathway which promotes reproductive growth; in yeast two-hybrid studies, DAF-3 interacts with SMA-3, another Smad protein that does not appear to have a role in dauer formation; a DAF-3::GFP fusion protein is expressed in many tissues that undergo remodeling during dauer development; DAF-3 localizes predominantly to the cytoplasm, but is also found associated with chromosomes in mitotic cells.
F37D6.6 F37D6.6 P W All gene names: tag-68; F37D6.6; 1L81; CE36156; WBGene00006445; WP:CE36156