|Gene list file name:||Fox2005_S14-T2_unc-4_neuron-transcript_metabotropi|
|Type of gene identifier:||Cosmid name|
|Description:||Fox et al 2005 Additional File 14/Table2: Summary of unc-4::GFP enriched and expressed (EGs) transcripts in selected categories. This file is an expanded version of Table 2 (see text) in which EGs are added to the list of enriched genes. Genes are organized as in Table 2 according to molecular function (KOG description, other description http://www.wormbase.org). Statistical rank is indicated for each enriched transcript and "EG" designates transcripts that are EGs.|
|Organism:||Caenorhabditis elegans (nematode)|
|Gene list type:||Experimental|
Gene name Source Gene ID Annotation Date Added by
F35H10.10 F35H10.10 P W All gene names: CELF35-1; F35H10.10; 4J72; CE24945; WBGene00018073; WP:CE24945
F45H11.4 F45H11.4 P W All gene names: mgl-2; F45H11.4; 1K960; CE33786; NM_060319; WBGene00003233; WP:CE33786 WormBase description: mgl-2 encodes a Group I metabotropic glutamate receptor (OMIM:604473, 604102, loss-of-function mutations in mice are associated with defects in long-term potentiation); by homology, MGL-2 is predicted to function as a post-synaptic G protein-coupled receptor that, in response to glutamate binding, stimulates phospholipase C activity and increases neuronal excitation, and in mammalian tissue culture cells, glutamate stimulation of MGL-2 does result in increased phosphoinositide turnover; a mutation in mgl-2 indicates that it is required for normal head movements and tap reversal reflexes, while loss of mgl-2 activity via large-scale RNAi screens indicates that MGL-2 is also required for embryogenesis; a mgl-2::GFP reporter is expressed in interneurons. WormBase CDS description: metabotropic glutamate receptor
F47D12.1 F47D12.1 P W All gene names: gar-2; F47D12.1; F47D12.1b.1; F47D12.1b.2; 3H409; ACM2_CAEEL; CE01946; CE24987; CE30134; CE30135; CE32893; WBGene00001518; WP:CE01946; WP:CE24987; WP:CE30134; WP:CE30135; WP:CE32893 WormBase description: gar-2 encodes a novel, seven transmembrane-domain G protein-coupled acetylcholine receptor (AChR); when expressed in Xenopus oocytes treated with acetylcholine, GAR-2 is able to activate a mammalian G protein-activated inwardly rectifying K+ (GIRK1) channel, but not other channels, suggesting that GAR-2 couples to G proteins of the Gi family; pharmacological analyses indicate, however, that GAR-2 exhibits properties distinct from mammalian muscarinic AChRs; gar-2 is expressed from mid-embryogenesis through adulthood with expression seen in ciliated head neurons, ventral cord neurons, and the HSN (hermaphrodite-specific neuron). WormBase CDS description: G-protein-linked acetylcholine receptor GAR-2
Y22D7AR.13 Y22D7AR.13 P W All gene names: 5HT-Ce; cer-1; ser-4; Y22D7AR.13; Y22D7AR.13.1; Y22D7AR.13.2; 3C814; CE29370; NM_065051; WBGene00004779; WP:CE29370 WormBase description: ser-4 encodes an ortholog of mammalian 5-HT1 metabotropic serotonin receptors; SER-4 is required for normal inhibition of movement by 5-HT, with ser-4 mutants being hyperactive; SER-4 is partly required for male tail curling, with ser-4 mutants showing reduced curling in exogenous 5-HT; SER-4 is dispensable for the stimulation of egg-laying by 5-HT and by the uptake inhibitor fluoxetine; SER-4 may actually inhibit egg-laying, since egg-laying ser-4 mutants are moderately hypersensitive to 5-HT, and mutant ser-4 hermaphrodites are partly depleted of eggs, suggesting that their egg-laying is weakly constitutive; however, SER-4 is required for stimulation of egg-laying by the tricyclic antidepressant imipramine, suggesting that imipramine drives HSNs to secrete some non-5-HT neurotransmitter which then activates SER-4; SER-4 is expressed in neurons (RIB and RIS, other head, pharyngeal, sublateral, retrovesicular ganglion, PVT, and either DVA or DVC); SER-4 has a low affinity for serotonin (5-HT), and overall pharmacological similarities to mammalian 5-HT1 receptors; SER-4 is probably antagonized by mianserin; heterologously expressed SER-4, when challenged with 5-HT, diminishes intracellular adenylate cyclase activity; LIM-6 is required for normal expression of SER-4 in RIS interneurons.
Y40H4A.1 Y40H4A.1 P W All gene names: acm-3; gar-3; gar-3a; Y40H4A.1; Y40H4A.1a.1; Y40H4A.1a.2; Y40H4A.1b.1; Y40H4A.1b.2; Y40H4A.A; 5P46; ACM3_CAEEL; CE27783; CE35800; NM_074207; WBGene00001519; WP:CE27783; WP:CE35800 WormBase description: gar-3 encodes a muscarinic acetylcholine receptor; gar-3 activity is required for regulation of membrane potential and excitation-contraction coupling in pharyngeal muscle and thus, for normal feeding behavior; in regulating pharyngeal pumping, GAR-3 likely acts upstream of GPB-2, a G-protein beta-subunit; a gar-3::gfp reporter fusion is expressed in the I3 pharyngeal neuron, extrapharyngeal neurons, and in pharyngeal muscles, where expression is highest in the terminal bulb.
Y41G9A.4 Y41G9A.4 P W All gene names: Y41G9A.4; CE30006; CE31257; WBGene00021528; WP:CE30006; WP:CE31257; XD585 WormBase description: glutamate receptor