HWienver et al 2005 ST1 Progressive increased exp, 31 genes Gene list file name: HWiener2005_ST1_progressive-increase-in-daf-2 Type of gene identifier: Cosmid name Description: HWienver et al 2005 Supplement Table1: Progressive increase gene expression in daf-2 worm Organism: Caenorhabditis elegans (nematode) Gene list type: Experimental Gene name Source Gene ID All gene names WormBase description WormBase CDS description Proteome description Member of lists (Publications) Other annotations F44E5.5 F44E5.5 F44E5.5; F44E5.5.1; F44E5.5.2; 2M51; WBGene00009692 Heat shock hsp70 proteins R107.7 gst-1 gst-1; R107.7; R107.7.1; R107.7.2; 3K149; CE00302; GSTP1_CAEEL; NM_066605; WBGene00001749; WP:CE00302 gst-1 encodes a putative glutathione S-transferase with highest similarity to the pi class. glutathione S-transferase F26D10.3 hsp-1 hsp-1; F26D10.3; F26D10.3.1; F26D10.3.2; F26D10.3.3; T28F3.2; 4S223; CE09682; HSP7A_CAEEL; NM_070667; WBGene00002005; WP:CE09682 hsp-1 encodes hsp70A, a member of the heat shock family of proteins; hsp70A is closely related to the Drosophila heat inducible hsp70s and the S. cerevisiae SSA hsp70 subfamily; the hsp-1 gene is normally expressed throughout development and upon heat-shock the hsp-1 mRNA is enhanced 2-6 fold; down-regulation of hsp-1 via RNA interference results in a small reduction in the life-span of an age-1 mutant indicating that hsp-1 may play some role in regulating longevity. HSP-1 heat shock 70kd protein A F38E11.1 hsp-12.3 hsp-12.3; F38E11.1; 4K208; CE03293; NM_069266; WBGene00002012; WP:CE03293 alpha-B-crystallin F38E11.2 hsp-12.6 hsp-12.6; hsp-20; F38E11.2; 4K210; CE03294; NM_069267; Q20165_CAEEL; WBGene00002013; WBGene00002022; WP:CE03294 alpha-B-crystallin T27E4.8 hsp-16.1 hsp-16.1; hsp-16; T27E4.8; 5J568; CE14249; NM_072953; WBGene00002015; WP:CE14249 hsp-16.1 encodes a 16-kD heat shock protein (HSP) that is a member of the hsp16/hsp20/alphaB-crystallin (HSP16) family of heat shock proteins, and that is identical to the protein encoded by hsp-16.11; an hsp-16.1 reporter fusion, expressed broadly but most strongly in muscle and hypodermis, is induced solely in response to heat shock or other environmental stresses; expression is detectable in somatic tissues in post-gastrulation embryos, all larval stages, and in adults; HSP-16.1 is likely to function as a passive ligand temporarily preventing unfolded proteins from aggregating. heat shock protein HSP16-1 T27E4.2 hsp-16.11 hsp-16.11; T27E4.2; 5J571; HSP11_CAEEL; NM_072956; WBGene00002017 hsp-16.11 encodes a 16-kD heat shock protein (HSP) that is a member of the hsp16/hsp20/alphaB-crystallin (HSP16) family of heat shock proteins, and that is identical to the protein encoded by hsp-16.1; hsp-16.11 expression is induced in response to heat shock or other environmental stresses; HSP-16.11 is likely to function as passive ligand temporarily preventing unfolded proteins from aggregating; HSP-16.11 has been shown to interact with intracellular human beta amyloid peptide, a primary component of the extracellular plaques found in Alzheimer's disease. heat shock protein HSP16-1 Y46H3A.3 hsp-16.2 hsp-16.2; Y46H3A.3; Y46H3A.D; 5C282; CE22002; HSP12_CAEEL; NM_071106; WBGene00002016; WP:CE22002 hsp-16.2 encodes a 16-kD heat shock protein (HSP) that is a member of the hsp16/hsp20/alphaB-crystallin (HSP16) family of heat shock proteins; hsp-16.2 expression, strongest in intestine and pharynx, is induced in response to heat shock or other environmental stresses; HSP-16.2 has been shown to interact with intracellular human beta amyloid peptide, a primary component of the extracellular plaques found in Alzheimer's disease; HSP-16.2 is likely to function as a passive ligand temporarily preventing unfolded proteins from aggregating. heat shock protein Y46H3A.2 hsp-16.41 hsp-16.41; HSP16-41; Y46H3A.2; Y46H3A.E; 5C283; CE22003; HSP16_CAEEL; NM_071107; WBGene00002018; WP:CE22003 hsp-16.41 encodes a 16-kD heat shock protein (HSP) that is a member of the hsp16/hsp20/alphaB-crystallin (HSP16) family of heat shock proteins; an hsp-16.41 reporter fusion, expressed broadly but strongest in intestine and pharynx, is induced in response to heat shock or other environmental stresses; expression is detectable in somatic tissues in post-gastrulation embryos, all larval stages, and in adults; HSP-16.41 is likely to function as a passive ligand temporarily preventing unfolded proteins from aggregating. heat shock protein T27E4.9 hsp-16.49 hsp-16.49; T27E4.9; 5J570; HSP17_CAEEL; NM_072955; WBGene00002020 hsp-16.49 encodes a 16-kD heat shock protein (HSP) that is a member of the hsp16/hsp20/alphaB-crystallin (HSP16) family of heat shock proteins, and that is identical to the protein encoded by hsp-16.48; HSP-16.49 is likely to function as a passive ligand temporarily preventing unfolded proteins from aggregating. heat shock protein HSP16-48 C15H9.6 hsp-3 hsp-3; C15H9.6; C15H9.6.1; C15H9.6.2; C15H9.6.3; CE08177; HSP7C_CAEEL; NM_076618; WBGene00002007; WP:CE08177; XG708 hsp-3 encodes a heat shock response 70 (hsp70) protein orthologous to human glucose regulated protein 78 (grp78/BiP, OMIM:138120); HSP-3 likely functions as a molecular chaperone, and is expressed constitutively (expression is not heat inducible) throughout development with greatest abundance during the L1 larval stage; HSP-3 contains a long hydrophobic amino terminus and a carboxyl terminal KDEL sequence suggesting that it may be retained in the endoplasmic reticulum. heat shock protein C37H5.8 hsp-6 hsp-6; mot-2; C37H5.8; 5F304; CE08631; HSP7F_CAEEL; NM_071890; WBGene00002010; WP:CE08631 hsp-6 encodes a mitochondrial-specific chaperone that is a member of the DnaK/Hsp70 superfamily of molecular chaperones; hsp-6 is believed to be involved in the mitochondrial unfolded protein response, as hsp-6 expression, normally broadly detected from the L1 larval through adult stages of development, is greatly increased in response to treatments that disrupt mitochondrial protein handling; loss of hsp-6 activity via RNAi results in severe growth defects with arrest at embryonic and early larval stages of development. heat shock 70 protein M28.5 M28.5 phi-9; M28.5; M28.5.1; M28.5.2; 2K948; CE02283; NH2L1_CAEEL; SNU13CE; WBGene00010896; WP:CE02283 ribosomal protein (L7AE family) K11G9.6 mtl-1 met-I; mtl-1; K11G9.6; 5H172; CE07379; MT1_CAEEL; NM_072295; WBGene00003473; WP:CE07379 Y37E3.7 rpa-1 rpa-1; Y37E3.7; Y37E3.7.1; Y37E3.7.2; 1C636; CE26658; NM_170818; RLA1_CAEEL; WBGene00004409; WP:CE26658 rpa-1 encodes an acidic ribosomal subunit protein P1. C04F12.4 rpl-14 rpl-14; C04F12.4; C04F12.4.1; C04F12.4.2; 1K265; CE19677; NM_060175; WBGene00004426; WP:CE19677 rpl-14 encodes a large ribosomal subunit L14 protein. C09D4.5 rpl-19 rpl-19; C09D4.5; C09D4.5.1; C09D4.5.2; C09D4.5.3; 1G54; CE08034; NM_059207; RL19_CAEEL; WBGene00004431; WP:CE08034 rpl-19 encodes a large ribosomal subunit L19 protein. 60S ribosomal protein L19 B0250.1 rpl-2 rpl-2; B0250.1; B0250.1.1; B0250.1.2; 5U949; CE18478; NM_075539; RL8_CAEEL; WBGene00004413; WP:CE18478 rpl-2 encodes a large ribosomal subunit L8 protein. Ribosomal Proteins L2 E04A4.8 rpl-20 rpl-20; E04A4.8; E04A4.8.1; E04A4.8.2; 4F516; CE21392; NM_068229; RL18A_CAEEL; WBGene00004432; WP:CE21392 rpl-20 encodes a large ribosomal subunit L18a protein. ribosomal protein Y106G6H.3 rpl-30 rpl-30; Y106G6H.3; 1L13; CE20413; NM_060327; WBGene00004444; WP:CE20413 rpl-30 encodes a large ribosomal subunit L30 protein; by homology, RPL-30 is predicted to function in protein biosynthesis; in C. elegans, loss of rpl-30 function via RNA-mediated interference (RNAi) does not result in any obvious abnormalities. W09C5.6 rpl-31 rpl-31; W09C5.6; W09C5.6a.1; W09C5.6a.2; W09C5.6b.1; W09C5.6b.2; W09C5.6b.3; W09C5.6b.4; W09C5.6b.5; W09C5.6b.6; 1O244; CE20168; CE20169; NM_060990; NM_060991; RL31_CAEEL; WBGene00004445; WP:CE20168; WP:CE20169 rpl-31 encodes a large ribosomal subunit L31 protein. Ribosomal protein L31e ZK652.4 rpl-35 rpl-35; ZK652.4; ZK652.4.1; ZK652.4.2; ZK652.4.3; ZK652.4.4; ZK652.4.5; ZK652.4.6; 3I945; CE00450; NM_066301; RL35_CAEEL; WBGene00004449; WP:CE00450 rpl-35 encodes a large ribosomal subunit L35 protein. 60S ribosomal protein L35 B0041.4 rpl-4 rpl-4; B0041.4; B0041.4.1; B0041.4.2; B0041.4.3; 1F214; CE07669; NM_059015; RL4_CAEEL; WBGene00004415; WP:CE07669 rpl-4 encodes a large ribosomal subunit L4 protein. ribosomal protein L1 B0393.1 rps-0 rps-0; B0393.1; B0393.1.1; B0393.1.2; 3F842; CE00854; NM_065577; RSSA_CAEEL; WBGene00004469; WP:CE00854 rps-0 encodes a small ribosomal subunit SA protein that appears to function as both a ribosomal component and a laminin receptor; by homology, RPS-0 is predicted to play roles in protein biosynthesis and cell adhesion; in C. elegans, RPS-0 activity is required for embryonic and germline development, vulval morphogenesis, and the overall health of the animal. 40S ribosomal protein F40F11.1 rps-11 rps-11; F40F11.1; F40F11.1.1; F40F11.1.2; 4M367; CE05860; NM_069785; WBGene00004480; WP:CE05860 rps-11 encodes a small ribosomal subunit S11 protein; by homology, RPS-11 is predicted to function in protein biosynthesis; in C. elegans, RPS-11 activity is required for embryonic and germline development, as well as the overall health of the animal. ribosomal protein S11 C49H3.11 rps-2 rps-2; C49H3.11; C49H3.11.1; C49H3.11.2; C49H3.11.3; C49H3.11.4; 4I690; CE04237; NM_068921; RS2_CAEEL; WBGene00004471; WP:CE04237 rps-2 encodes a small ribosomal subunit S2 protein. ZC434.2 rps-7 rps-7; ZC434.2; ZC434.2.1; ZC434.2.2; 1K907; CE06577; NM_060307; RS7_CAEEL; WBGene00004476; WP:CE06577 rps-7 encodes a small ribosomal subunit S7 protein. 40S ribosomal protein S7 F42C5.8 rps-8 rps-8; F42C5.8; F42C5.8.1; F42C5.8.2; 4I78; CE04561; NM_068766; RS8_CAEEL; WBGene00004477; WP:CE04561 rps-8 encodes a small ribosomal subunit S8 protein; by homology, RPS-8 is predicted to function in protein biosynthesis; in C. elegans, RPS-8 activity is required for germline development and the overall health of the animal. 40S ribosomal protein S8 F43D9.4 sip-1 sec-1; sip-1; F43D9.4; F43D9.4.1; F43D9.4.2; 3L596; CE00994; NM_066915; SIP/1; SIP1_CAEEL; WBGene00004798; WP:CE00994 Heat shock hsp20 proteins F09E10.11 tts-1 tts-1; F09E10.11; NM_075886; NM_075887; WBGene00006650; XC122