|Gene list file name:||Blacque2005_T1_46-ciliated-genes|
|Type of gene identifier:||Cosmid name|
|Description:||Blacque et al 2005 T1 Shown are all genes (46 in total) that are enriched for SAGE tags in the ciliated-cell transcriptome (C), with R1.5-fold enrichment versus the pan-neural transcriptome (P) and R2.0-fold enrichment versus the muscle (M) and gut (G) transcriptomes, and with a canonically-positioned (Pos) putative X box (i.e., within 250 bp of the start codon). Only genes with homology to a human gene (Blast E-value < e?10) are represented.|
|Organism:||Caenorhabditis elegans (nematode)|
|Gene list type:||Experimental|
Gene name Source Gene ID Annotation Date Added by
C02H7.1 C02H7.1 P W All gene names: C02H7.1; CE06757; WBGene00015363; WP:CE06757; XB385
C26B9.5 C26B9.5 P W All gene names: C26B9.5; CE04098; WBGene00016134; WP:CE04098; XF949 WormBase description: lysosomal Pro-X carboxypeptidase
C27F2.1 C27F2.1 P W All gene names: C27F2.1; 3G79; CE38940; WBGene00016165; WP:CE38940
C47E8.6 C47E8.6 P W All gene names: C47E8.6; 5P171; CE35839; WBGene00008144; WP:CE35839
C48B6.8 C48B6.8 P W All gene names: C48B6.8; 1H494; CE32166; WBGene00016744; WP:CE32166
C54G7.4 C54G7.4 P W All gene names: C54G7.4; CE37621; WBGene00016935; WP:CE37621; XG166
D1009.5 D1009.5 P W All gene names: dylt-2; xbx-2; D1009.5; CE04289; NM_077110; WBGene00017014; WP:CE04289; XJ558
F08B12.1 F08B12.1 P W All gene names: F08B12.1; CE03162; WBGene00008571; WP:CE03162; XM11 WormBase description: F08B12.1 is orthologous to the human gene AC133-2 ANTIGEN (PROML1; OMIM:604365), which when mutated leads to disease.
F08C6.4 F08C6.4 P W All gene names: sto-1; F08C6.4; CE27924; NM_076880; STO1_CAEEL; WBGene00006063; WP:CE27924; XI183 WormBase description: Erythrocyte band 7 integral membrane protein (human)
F13B9.5 F13B9.5 P W All gene names: ksr-1; sar-2; sur-3; F13B9.5; F13B9.5.1; F13B9.5.2; CE25854; NM_076995; WBGene00002239; WP:CE25854; XI901
F19H8.3 F19H8.3 P W All gene names: arl-3; F19H8.3; 2O895; ARL3_CAEEL; CE15872; NM_064636; WBGene00000188; WP:CE15872 WormBase description: arl-3 encodes a member of the ARL (ADP-ribosylation factor(ARF)-like) family of proteins which are very similar to ARF proteins but lack the ability to stimulate ADP ribosylation by cholera toxin; as loss of arl-3 activity via RNA-mediated interference (RNAi) does not result in any abnormalities, the precise role of ARL-3 is not yet known. WormBase CDS description: ADP-ribosylation factors (Arf family) (contains ATP/GTP binding P-loop)
F20D12.3 F20D12.3 P W All gene names: bbs-2; F20D12.3; 4I701; CE04433; NM_068924; WBGene00000242; WP:CE04433 WormBase description: bbs-2 is orthologous to human BBS2 (OMIM:606151, mutated in Bardet-Biedl syndrome 2); while the function of BBS-2 is unknown, it shares conserved domains with its human paralogs BBS1 and BBS7, which also are mutated in other Bardet-Biedl syndromes.
F32A6.2 F32A6.2 P W All gene names: F32A6.2; CE34008; WBGene00017973; WP:CE34008; XF921
F32A6.5 F32A6.5 P W All gene names: sto-2; F32A6.5; CE33065; NM_076501; STO2_CAEEL; WBGene00006064; WP:CE33065; XF928
F35D2.4 F35D2.4 P W All gene names: F35D2.4; 2H866; CE02726; WBGene00018042; WP:CE02726
F38G1.1 F38G1.1 P W All gene names: che-2; F38G1.1; F38G1.1.1; F38G1.1.2; CE25876; NM_075705; WBGene00000484; WP:CE25876; XB103 WormBase description: che-2 encodes a protein that contains G-protein beta-like WD-40 repeats that affects chemotaxis, dauer formation, and longevity; expressed in the cilia of most ciliated sensory neurons, some head neurons, and male tail rays. WormBase CDS description: G-beta-repeats
F59C6.7 F59C6.7 P W All gene names: che-13; che-9; F59C6.7; 1L82; CE31704; NM_060348; WBGene00000492; WP:CE31704 WormBase description: che-13 encodes a novel protein homologous to mammalian IFT57/Hippi (OMIM:606621, protein interactor of Huntingtin-interacting protein 1 that is implicated in neuronal apoptosis in the Huntington disease state); CHE-13 is a proposed component of the intraflagellar transport (IFT) complex B, and is required for the construction and maintenance of cilia on a subset of sensory neurons; in addition, CHE-13 is required for proper localization of OSM-5, a murine polaris homolog, to IFT complex B; CHE-13 is expressed in ciliated sensory neurons including the amphids, phasmids, inner and outer labial neurons, and sensory rays of the male tail, localizing to the cilia base (transition zone) as well as to the axoneme; che-13 expression, like that of ciliogenic genes osm-1, osm-5, osm-6, and che-2, is positively regulated by the DAF-19 RFX-type transcription factor.
F59D12.1 F59D12.1 P W All gene names: F59D12.1; CE11490; WBGene00010329; WP:CE11490; XQ289 WormBase description: G-protein coupled receptor (gastrin/cholecystokinin)
H01G02.2 H01G02.2 P W All gene names: H01G02.2; 4M562; CE35567; WBGene00010349; WP:CE35567 WormBase description: serine/threonine kinase (2 domains)
K03E6.4 K03E6.4 P W All gene names: K03E6.4; CE07330; Q21191_CAEEL; WBGene00019364; WP:CE07330; XB686
K06H7.3 K06H7.3 P W All gene names: K06H7.3; K06H7.3.1; K06H7.3.2; K06H7.3.3; 3J183; CE26941; NM_066364; WBGene00019457; WP:CE26941; YMX3_CAEEL WormBase description: Isopentenyl-diphosphate delta isomerase
K07G5.3 K07G5.3 P W All gene names: K07G5.3; 1H741; CE06131; WBGene00010642; WP:CE06131 WormBase description: C2 domain
K08D12.2 K08D12.2 P W All gene names: K08D12.2; 4C477; CE32468; WBGene00019536; WP:CE32468 WormBase description: K08D12.2 is orthologous to the human gene XRP2 PROTEIN (RP2; OMIM:312600), which when mutated leads to disease.
K10G6.4 K10G6.4 P W All gene names: K10G6.4; 2E264; CE28602; WBGene00019641; WP:CE28602
M04G12.3 M04G12.3 P W All gene names: gcy-34; M04G12.3; 5N864; CE12426; GCY34_CAEEL; NM_073918; WBGene00001554; WP:CE12426 WormBase description: gcy-34 encodes a predicted soluble guanylyl cyclase that is expressed in four candidate sensory neurons connected to the pseudocoelom, URXL, URXR, AQR, and PQR; as loss of gcy-34 activity via RNA-mediated interference does not result in any abnormalities, the precise role of GCY-34 in C. elegans development and/or behavior is not yet known; GCY-34 expression in neurons connected to the pseudocoelom suggests, however, that GCY-34 may play a role in fluid homeostasis. WormBase CDS description: guanylate cyclase beta chain like
R01H10.6 R01H10.6 P W All gene names: bbs-5; R01H10.6; 3L348; CE01042; NM_066871; Q21626_CAEEL; WBGene00010974; WP:CE01042
R11A8.2 R11A8.2 P W All gene names: R11A8.2; 4L123; CE06300; Q21924_CAEEL; WBGene00011237; WP:CE06300
R13G10.2 R13G10.2 P W All gene names: amx-1; R13G10.2; 3E915; AMX1_CAEEL; CE25088; NM_065371; WBGene00000137; WP:CE25088 WormBase description: monoamine oxidase
R166.3 R166.3 P W All gene names: R166.3; 2K828; AMERL_CAEEL; CE03582; WBGene00011303; WP:CE03582 WormBase description: The R166.3 gene encodes an unfamiliar protein, with homologs in yeast and archaea, that is orthologous to the human gene ALPORT SYNDROME, MENTAL RETARDATION, MIDFACE HYPOPLASIA, AND ELLIPTOCYTOSIS CHROMOSOMAL REGION GENE 1 (AMMECR1; OMIM:300195); AMMECR1, when mutated, may be at least partially responsible for mental retardation, midface hypoplasia, or elliptocytosis.
R31.3 R31.3 P W All gene names: osm-6; R31.3; 5M406; CE27774; NM_171545; WBGene00003886; WP:CE27774 WormBase description: osm-6 males are defective in their response to hermaphrodite-derived diffusible cues. WormBase CDS description: N-acetyllactosamine synthase
T01D1.6 T01D1.6 P W All gene names: abu-11; pqn-61; T01D1.6; 2A484; CE28071; NM_061278; P91419_CAEEL; WBGene00000034; WP:CE28071 WormBase description: abu-11 encodes a transmembrane protein with a predicted signal sequence, a glutamine/asparagine-rich domain and multiple cysteine-rich repeats (DUF139); abu-11 expression is induced by blockage of the unfolded-protein response in the endoplasmic reticulum, and ABU-11 may help protect the organism from damage by improperly folded nascent protein.
T06G6.3 T06G6.3 P W All gene names: T06G6.3; 1N300; CE32489; CE37142; O18051_CAEEL; WBGene00011545; WP:CE32489; WP:CE37142
T27B1.1 T27B1.1 P W All gene names: osm-1; T27B1.1; CE39420; NM_078280; WBGene00003883; WP:CE39420; XR165 WormBase description: osm-1 encodes a predicted intraflagellar transport (IFT) raft protein and is a presumptive cargo molecule for kinesin-II, and OSM-1 is required along with OSM-6 for the proper assembly of the middle segments of sensory cilia; osm-1 may act in a pathway with avr-14 to affect resistance to ivermectin-induced cessation of pumping, and mutants are defective in avoidance of solutions of high osmotic strength. WormBase CDS description: leucine zipper transcription factor(weak)
Y105E8A.5 Y105E8A.5 P W All gene names: bbs-1; Y105E8A.5; 1O962; CE25181; NM_170937; WBGene00000241; WP:CE25181
Y32G9A.6 Y32G9A.6 P W All gene names: Y32G9A.6; 5C377; CE27598; WBGene00021304; WP:CE27598
Y37A1A.3 Y37A1A.3 P W All gene names: Y37A1A.3; 4O660; CE39819; WBGene00012536; WP:CE39819 WormBase description: Sugar (and other) transporters
Y38F2AL.2 Y38F2AL.2 P W All gene names: Y38F2AL.2; 4D70; CE21622; Q9N423_CAEEL; WBGene00021416; WP:CE21622
Y41D4A.4 Y41D4A.4 P W All gene names: Y41D4A.4; Y41D4A.4.1; Y41D4A.4.2; 4C515; CE21847; WBGene00021506; WP:CE21847
Y41G9A.1 Y41G9A.1 P W All gene names: osm-5; Y41G9A.1; CE28361; NM_076110; WBGene00003885; WP:CE28361; XD609 WormBase description: The osm-5 gene encodes a homolog of the murine cystic kidney disease gene Tg737 that is required for the production of cilia in sensory neurons.
ZC84.6 ZC84.6 P W All gene names: ZC84.6; 3K284; CE15024; WBGene00013849; WP:CE15024 WormBase description: Serine protease inhibitor
ZK520.1 ZK520.1 P W All gene names: ZK520.1; ZK520.1.1; ZK520.1.2; 3O766; CE33907; WBGene00013990; WP:CE33907