|Gene list file name:||Fox2005_S14-T2_unc-4_neuron-transcript_Addhesion-P|
|Type of gene identifier:||Cosmid name|
|Description:||Fox et al 2005 Additional File 14/Table2: Summary of unc-4::GFP enriched and expressed (EGs) transcripts in selected categories. This file is an expanded version of Table 2 (see text) in which EGs are added to the list of enriched genes. Genes are organized as in Table 2 according to molecular function (KOG description, other description http://www.wormbase.org). Statistical rank is indicated for each enriched transcript and "EG" designates transcripts that are EGs.|
|Organism:||Caenorhabditis elegans (nematode)|
|Gene list type:||Experimental|
Gene name Source Gene ID Annotation Date Added by
B0034.3 B0034.3 P W All gene names: casy-1; cdh-11; B0034.3; B0034.3c.1; B0034.3c.2; 2G236; CE27048; CE27049; CE39540; NM_062788; Q9BIB5_CAEEL; WBGene00000403; WP:CE27048; WP:CE27049; WP:CE39540 WormBase description: A homolog of a member of the cadherin superfamily which is involved in cell-cell adhesion.
C18F3.2 C18F3.2 P W All gene names: lad-1; sax-7; C18F3.2; 4I847; CE37202; CE38779; CE38935; CE38936; NM_068948; WBGene00004732; WP:CE37202; WP:CE38779; WP:CE38935; WP:CE38936 WormBase description: sax-7 encodes the C. elegans ortholog of L1CAM; SAX-7 is ubiquitously expressed at sites of cell-cell contact, and is required for germline development, embryonic morphogenesis, and gonadal morphogenesis; SAX-7 interacts physically with the ankyrin UNC-44, and nonphosphorylated SAX-7 is colocalized with UNC-44 at sites of cellular contact in vivo.
C47E8.7 C47E8.7 P W All gene names: unc-112; C47E8.7; C47E8.7.1; C47E8.7.2; 5P172; CE05443; NM_074227; UN112_CAEEL; WBGene00006836; WP:CE05443 WormBase description: The unc-112 gene encodes a pleckstrin homology domain-containing protein, orthologous to human Mitogen inducible gene-2, that is required for assembly of muscle dense bodies and M lines during embryogenesis; UNC-112 is a dense body/M-line component and requires PAT-3/beta-integrin, UNC-52/perlecan, and PAT-4/integrin-linked kinase for proper localization; UNC-112 binds PAT-4 directly, forms a ternary complex with PAT-4 and PAT-6/actopaxin, and is required for recruitment of PAT-3 and PAT-4 to muscle cell attachment sites; viable unc-112 mutations are suppressed by mutation of dim-1. WormBase CDS description: mitogen inducible MIG-2 protein like
C53A5.13 C53A5.13 P W All gene names: C53A5.13; 5P33; CE35843; WBGene00008270; WP:CE35843
C53B7.1 C53B7.1 P W All gene names: rig-3; C53B7.1; CE06971; NM_076754; WBGene00004370; WP:CE06971; XH479
F15B9.7 F15B9.7 P W All gene names: cdh-6; F15B9.7; 5N513; CE37969; NM_073855; WBGene00000398; WP:CE37969 WormBase description: cdh-6 encodes a cadherin homolog, with a domain resembling seven transmembrane-sequence receptors, that may be orthologous to the Drosophila cadherin STAN; both CDH-6 and STAN are homologous to secretin-type receptors, have extracellular domains of similar lengths and domain compositions (with similar numbers of cadherin, EGF, laminin G, GFS, and HormR domains); however, the cytoplasmic domains of CDH-6 and STAN are dissimilar. WormBase CDS description: cadherin
F25F2.2 F25F2.2 P W All gene names: cdh-4; F25F2.2; 3F625; CADH4_CAEEL; CE00961; NM_065516; WBGene00000396; WP:CE00961 WormBase description: A homolog of a member of the cadherin superfamily that is involved in cell-cell adhesion. WormBase CDS description: Approximately 25 cadherin-repeats, 3 EGF domains and one Laminin G domain
F42F12.2 F42F12.2 P W All gene names: zig-2; F42F12.2; CE03313; NM_077668; WBGene00006979; WP:CE03313; XM956 WormBase description: IG-like C2-type domains
F54D7.4 F54D7.4 P W All gene names: zig-7; F54D7.4; 1F360; CE33929; NM_059050; WBGene00006984; WP:CE33929
F57B9.5 F57B9.5 P W All gene names: byn-1; F57B9.5; F57B9.5.1; F57B9.5.2; 3I25; BYN1_CAEEL; CE25013; NM_066109; WBGene00000276; WP:CE25013 WormBase description: byn-1 encodes a homolog of mammalian BYSTIN-LIKE (BYSL; OMIM:603871).
K02E10.8 K02E10.8 P W All gene names: syg-1; K02E10.8; CE37121; NM_076056; WBGene00006365; WP:CE37121; XD128 WormBase description: syg-1 encodes a novel transmembrane protein that is a member of the immunoglobulin superfamily of proteins; during larval development, SYG-1 activity is required cell autonomously within the HSNL neuron to specify proper synaptic specificity with its targets, such as vulval muscles and the VC neuron; in regulating synapse formation, SYG-1 acts as a receptor for a second immunoglobulin superfamily protein, SYG-2, a synaptic guidepost protein that interacts with SYG-1 and whose activity is essential for proper SYG-1 localization in HSNL; expression of a SYG-1::GFP reporter fusion in HSNL under the control of the unc-86 promoter reveals that SYG-1 localizes to axons and accumulates at future sites of synaptic vesicle clustering, while expression under an endogenous reporter reveals weak expression in head motorneurons, occasionally in HSN neurons, and in other cells in the vulval region.
K10C3.3 K10C3.3 P W All gene names: zig-1; K10C3.3; 1K427; CE30349; NM_060207; WBGene00006978; WP:CE30349 WormBase description: IG superfamily repeats (I-type)
R05H10.6 R05H10.6 P W All gene names: cdh-7; R05H10.6; 2P135; CE38092; NM_064674; WBGene00000399; WP:CE38092 WormBase description: cdh-7 encodes a protein that contains a cadherin domain. WormBase CDS description: Cadherin (3 domains)
R10F2.1 R10F2.1 P W All gene names: R10F2.1; 3E21; CE38097; NM_065240; WBGene00019994; WP:CE38097 WormBase description: cdh-1 encodes a cadherin that is similar, in the extracellular domain, to the Drosophila cadherin Dachsous (Ds); although the precise role of cdh-1 in C. elegans development and/or behavior is not yet known, loss of cdh-1 activity via RNAi using the hypersensitive rrf-3 strain can result in locomotion and growth defects, as well as larval lethality. WormBase CDS description: cadherin-containing cell adhesion protein
R10F2.4 R10F2.2 P W
T19D12.6 T19D12.6 P W All gene names: T19D12.6; 2G928; CE37555; WBGene00020581; WP:CE37555 WormBase description: laminin repeats; EGF-like repeats
W02B9.1 W02B9.1 P W All gene names: hmr-1; W02B9.1; Y52B11B.2; 1L668; CE25133; CE30357; HMR1_CAEEL; WBGene00001980; WP:CE25133; WP:CE30357 WormBase description: hmr-1 encodes two isoforms of a classical cadherin that contain extracellular cadherin, EGF-like, and laminin G domains as well as a highly conserved intracellular domain that binds beta-catenin; by homology, the HMR-1 proteins are predicted to function as calcium-dependent, homophilic cell-cell adhesion receptors; in vivo, HMR-1A activity is required for mediating the cell migrations, cell shape changes, and presumably actin cytoskeleton rearrangements that occur during embryonic morphogenesis; HMR-1B is required for fasciculation and outgrowth of a subset of motor neuron processes; HMR-1 antibodies detect expression in all embryonic blastomeres at early stages of development but as hypodermal adherens junctions form and morphogenesis begins, HMR-1 becomes highly expressed in the apical junctions of all hypodermal cells; later, HMR-1 is expressed primarily at the apical margins of hypodermal, pharyngeal, and intestinal cells in a pattern consistent with localization to adherens junctions; an HMR-1B reporter fusion is expressed in neurons, including the DD, VD, and AS class of motor neurons; HMR-1 activity is required for proper localization of other junctional components, such as HMP-1/alpha-catenin and HMP-2/beta-catenin, but not for localization of AJM-1, the junctional component recognized by the MH27 antibody. WormBase CDS description: cadherin
Y42H9B.2 Y42H9B.2 P W All gene names: rig-4; Y42H9B.2; 4I756; CE33870; NM_068938; SDK_CAEEL; WBGene00004371; WP:CE33870