|Gene list file name:||Robertson2005_Fig3B_maternal-genes|
|Type of gene identifier:||MA primer pair (sjj)|
|Description:||Robertson et al 2005 Fig 3B: 16 maternal genes that are maternally supplied and either maintained at a high level in early embryos(Type I) or degraded in somatic blastomeres but maintained in the germline lineage in early embryos(Type II). Type II maternal genes is downregulated in 12-cell-stage compared to 4-cell-stage. Type I basically remain unchanged.|
|Organism:||Caenorhabditis elegans (nematode)|
|Gene list type:||Experimental|
Gene name Source Gene ID Annotation Date Added by
AH6.5 AH6.5 P W All gene names: mex-6; AH6.5; 2J815; CE26846; MEX6_CAEEL; NM_063642; WBGene00003231; WP:CE26846 WormBase description: mex-6 encodes a CCCH zinc-finger protein highly similar to MEX-5 that functions with MEX-5 to affect embryonic viability, establish soma germline asymmetry in embryos and establish PIE-1, MEX-1, and POS-1 asymmetry in embryos, and also affects formation of intestinal cells; MEX-6 and MEX-5 may act downstream of the PAR proteins. WormBase CDS description: zinc finger protein
C09G9.6 C09G9.6 P W All gene names: moe-1; oma-1; C09G9.6; C09G9.6.1; C09G9.6.2; 4J655; CE03005; NM_069141; WBGene00003864; WP:CE03005 WormBase description: The oma-1 gene encodes a zinc finger protein of the TIS11 finger type that is paralogous to OMA-2; while either oma-1 or oma-2 individually have no obvious mutant phenotype, a normal copy of at least one of these genes is required for oocyte maturation. WormBase CDS description: Zinc finger protein
C47E8.5 C47E8.5 P W All gene names: daf-21; tax-3; C47E8.5; C47E8.5.1; C47E8.5.2; C47E8.5.3; 5P167; CE05441; HSP90_CAEEL; NM_074225; WBGene00000915; WP:CE05441 WormBase description: daf-21 encodes a member of the Hsp90 family of molecular chaperones; DAF-21 activity is required for larval development, negative regulation of dauer larva formation, and a number of specific chemosensory behaviors, such as the response to chemicals and odorants detected by the ASE and AWC sensory neurons; a daf-21 sensory defect can be rescued by a cyclic GMP analogue, suggesting that, in regulating chemosensory behaviors, DAF-21 acts at a similar point as the DAF-11 guanylyl cyclase; down-regulation of daf-21 via RNAi results in a small but reproducible reduction in age-1 life span, suggesting that daf-21 is part of a chaperone network required for the extended life span seen in age-1 mutant animals. WormBase CDS description: heat shock protein (HSP90)
F02A9.6 F02A9.6 P W All gene names: emb-33; glp-1; F02A9.6; 3K187; CE00237; GLP1_CAEEL; NM_066613; WBGene00001609; WP:CE00237 WormBase description: glp-1 encodes an N-glycosylated transmembrane protein that, along with LIN-12, comprises one of two C. elegans members of the LIN-12/Notch family of receptors; from the N- to the C-terminus, GLP-1 is characterized by ten extracellular EGF-like repeats, three LIN-12/Notch repeats, a CC-linker, a transmembrane domain, a RAM domain, six intracellular ankyrin repeats, and a PEST sequence; in C. elegans, GLP-1 activity is required for cell fate specification in germline and somatic tissues; in the germline, GLP-1, acting as a receptor for the DSL family ligand LAG-2, is essential for mitotic proliferation of germ cells and maintenance of germline stem cells; in somatic tissues, maternally provided GLP-1, acting as a receptor for the DSL family ligand APX-1, is required for inductive interactions that specify the fates of certain embryonic blastomeres; GLP-1 is also required for some later embryonic cell fate decisions, and in these decisions its activity is functionally redundant with that of LIN-12; GLP-1 expression is regulated temporally and spatially via translational control, as GLP-1 mRNA, present ubiquitously in the germline and embryo, yields detectable protein solely in lateral, interior, and endomembranes of distal, mitotic germ cells, and then predominantly in the AB blastomere and its descendants in the early embryo; proper spatial translation of glp-1 mRNA in the embryo is dependent upon genes such as the par genes, that are required for normal anterior-posterior asymmetry in the early embryo; signaling through GLP-1 controls the activity of the downstream Notch pathway components LAG-3 and LAG-1, the latter being predicted to function as part of a transcriptional feedback mechanism that positively regulates GLP-1 expression; signaling through the DNA-binding protein LAG-1 is believed to involve a direct interaction between LAG-1 and the GLP-1 RAM and ankyrin domains WormBase CDS description: GLP-1 protein
F31E3.5 F31E3.5 P W All gene names: eft-3; eln-1; glp-3; F31E3.5; F31E3.5.1; F31E3.5.2; F31E3.5.3; F31E3.5.4; 3I58; CE01270; NM_066119; WBGene00001168; WBGene00001610; WP:CE01270 WormBase description: eft-3 encodes a translation elongation factor 1-alpha homolog that is required for embryonic viability, fertility, and germline maintenance; the EFT-3 protein sequence is encoded both by eft-3 (F31E3.5) itself but also by R03G5.1. WormBase CDS description: Elongation factor 1-alpha
F33A8.3 F33A8.3 P W All gene names: cey-1; F33A8.3; F33A8.3.1; F33A8.3.2; 2L330; CE17755; NM_063965; WBGene00000472; WP:CE17755 WormBase description: cey-1 encodes a protein with a cold-shock/Y-box domain that is expressed in early embryonic blastomeres (at the 15-cell stage, i.e., pre-gastrulation), but is normally repressed in early germline blastomeres by PIE-1; it is predicted to be mitochondrial by phylogenetic profiling. WormBase CDS description: 'Cold-shock' DNA-binding domain
F38E1.7 F38E1.7 P W All gene names: mom-2; F38E1.7; 5I837; CE17806; MOM2_CAEEL; NM_072753; WBGene00003395; WP:CE17806 WormBase description: mom-2 encodes a member of the Wnt family of secreted signaling glycoproteins that is required for induction of endodermal (gut) tissue in the 4-cell stage embryo; MOM-2, required in the inducing blastomere (P2) at the 4-cell stage, may be the ligand for MOM-5, a Frizzled homolog, thought to act in the receiving blastomere (EMS); MOM-2 genetically interacts in the same pathway as KIN-19, but parallel to APR-1; MOM-2 also may be a ligand for LIN-18, a Ryk homolog. WormBase CDS description: WNT family protein
F46F11.2 F46F11.2 P W All gene names: cey-2; F46F11.2; F46F11.2.1; F46F11.2.2; 1G189; CE10598; NM_059244; P91306_CAEEL; WBGene00000473; WP:CE10598 WormBase description: cey-2 encodes a cold-shock/Y-box domain-containing protein; by homology, CEY-2 is predicted to function as either an RNA-binding protein involved in translation or RNA processing, or a DNA-binding protein involved in transcriptional regulation; cey-2 mRNA is expressed maternally in the early embryo, in a pattern characteristic of class II maternal RNAs, which are initially detected throughout the embryo but restricted to the P, or germline, lineage as cell division progresses; as loss of cey-2 activity via large-scale RNAi screens does not result in any obvious abnormalities, the precise role of cey-2 in C. elegans development and/or behavior is not yet known.
F52E1.1 F52E1.1 P W All gene names: pos-1; F52E1.1; 5I895; CE04629; NM_072771; WBGene00004078; WP:CE04629 WormBase description: pos-1 encodes a CCCH-type zinc-finger protein; during embryogenesis, maternally provided POS-1 is essential for proper fate specification of germ cells, intestine, pharynx, and hypodermis; POS-1's role in cell fate specification is likely as a translational regulator, as POS-1 is required, in posterior blastomeres, for positive regulation of apx-1 mRNA translation and negative regulation of glp-1 mRNA translation via direct binding to the spatial control region (SCR) in the glp-1 mRNA 3' UTR; in regulating mRNA translation, POS-1 interacts with SPN-4, an RNP-type RNA binding protein, that may function to negatively regulate POS-1 activity; pos-1 mRNA is first detected in the gonads of L4 and adult animals, and is present uniformly in oocytes and newly fertilized embryos; during early embryonic divisions, pos-1 mRNA is present at higher levels in germline blastomeres until it disappears following the division of P4; POS-1 protein is first apparent at low levels in 1-cell embryos, with subsequent expression mirroring that of pos-1 mRNA: high levels in germline blastomeres until its disappearance after the P4 division; in the germline blastomeres P1, P2, P3, and P4, POS-1 colocalizes with cytoplasmic and perinuclear P granules. WormBase CDS description: zinc-finger protein
F57B9.6 F57B9.6 P W All gene names: inf-1; F57B9.6; F57B9.6a.1; F57B9.6a.2; 3I21; CE01341; CE38524; Ce1F; CeIF; IF4A_CAEEL; NM_066108; WBGene00002083; WP:CE01341; WP:CE38524 WormBase description: inf-1 encodes a protein with high similarity to eukaryotic initiation factor 4A.
M117.2 M117.2 P W All gene names: ftt-1; par-5; M117.2; M117.2.1; M117.2.2; M117.2.3; 14331_CAEEL; 4M586; CE06200; NM_069834; WBGene00003920; WP:CE06200 WormBase description: PAR-5 is a 14-3-3 protein. WormBase CDS description: 14-3-3 protein
R07G3.1 R07G3.1 P W All gene names: cdc-42; R07G3.1; R07G3.1.1; R07G3.1.2; 2H907; CDC42_CAEEL; CE02020; NM_063197; WBGene00000390; WP:CE02020 WormBase description: The cdc-42 gene encodes a RHO GTPase which controls polarity of both individual cells and developing embryos by regulating the localization of PAR proteins; it is expressed at hypodermal cell boundaries. WormBase CDS description: RAS protein
T19E7.2 T19E7.2 P W All gene names: skn-1; T19E7.2; T19E7.2c.1; T19E7.2c.2; T19E7.2c.3; T19E7.2c.4; T19E7.2c.5; T19E7.2c.6; 4G416; CE27591; CE31238; CE31239; NM_171345; NM_171346; NM_171347; SKN1_CAEEL; WBGene00004804; WP:CE27591; WP:CE31238; WP:CE31239 WormBase description: skn-1 encodes a transcription factor with similarity to the basic region of bZip transcription factors; during early embryogenesis, maternally provided SKN-1 is required for specification of the EMS blastomere, a mesendodermal precursor that gives rise to pharyngeal, muscle, and intestinal cells; later, during postembryonic development, SKN-1 functions in the p38 MAPK-mediated oxidative stress response pathway, as well as in regulation of lifespan; SKN-1 is detected at highest levels in nuclei of the P1 blastomere and its descendants through the 8-cell stage of embryogenesis; later in embryogenesis, SKN-1 is observed in all hypodermal and intestinal nuclei, with reporter constructs indicating that intestinal expression begins as early as the 50-100-cell stage; in larvae and young adults, SKN-1 reporters are expressed in the intestine and ASI neurons, with expression in intestinal nuclei greatly enhanced under stress-inducing conditions.
W03C9.7 W03C9.7 P W All gene names: mel-21; mex-1; W03C9.7; W03C9.7.1; W03C9.7.2; 2M261; CE28097; NM_064150; WBGene00003228; WP:CE28097 WormBase description: mex-1 encodes a CCCH-type zinc-finger protein that is required maternally for segregation of P granules, germ cell formation, and somatic cell differentiation in the early embryo; MEX-1 is expressed cytoplasmically in germ line blastomeres, is a component of P granules, and is required for restricting PIE-1 expression and function to these cells; mex-1 mRNA transcripts are also transiently associated with P granules. WormBase CDS description: Zinc finger C-x8-C-x5-C-x3-H type (and similar). (2 domains)
Y49E10.14 Y49E10.14 P W All gene names: pic-1; pie-1; Y49E10.14; 3N517; CE28134; NM_067218; PIE1_CAEEL; WBGene00004027; WP:CE28134 WormBase description: pie-1 encodes a C-x8-C-x5-C-x3-H-type zinc-finger protein; maternally provided PIE-1 is essential for germline cell fate determination, as it functions as a repressor of RNA polymerase II-dependent gene expression in the developing germ line; PIE-1 localization, initially uniform and then concentrated in the posterior germ cell lineages, is regulated by other maternally supplied gene products including PAR-1, MEX-5, and MEX-6. WormBase CDS description: Zinc finger C-x8-C-x5-C-x3-H type (and similar).
ZK863.6 ZK863.6 P W All gene names: dpy-30; ZK863.6; ZK863.6.1; ZK863.6.2; ZK863.6.3; 5M671; CE15445; DPY30_CAEEL; NM_073657; WBGene00001088; WP:CE15445 WormBase description: The dpy-30 gene encodes an essential nuclear protein required for hermaphrodite dosage compensation as well as normal male development; DPY-30 is expressed ubiquitously throughout development and can be detected in two different multiprotein complexes: the SDC complex involved in dosage compensation and a second complex containing NOX-1 (a WD repeat-containing protein) and ASH-2 (a trithorax-related protein) that is homologous to the yeast Set1p complex involved in epigenetic regulation of transcription. WormBase CDS description: DPY-30 protein