|Gene list file name:||Fox2005_S14-T2_unc-4_neuron-transcript_Endocytosis|
|Type of gene identifier:||Cosmid name|
|Description:||Fox et al 2005 Additional File 14/Table2: Summary of unc-4::GFP enriched and expressed (EGs) transcripts in selected categories. This file is an expanded version of Table 2 (see text) in which EGs are added to the list of enriched genes. Genes are organized as in Table 2 according to molecular function (KOG description, other description http://www.wormbase.org). Statistical rank is indicated for each enriched transcript and "EG" designates transcripts that are EGs.|
|Organism:||Caenorhabditis elegans (nematode)|
|Gene list type:||Experimental|
Gene name Source Gene ID Annotation Date Added by
C02C6.1 C02C6.1 P W All gene names: dyn-1; C02C6.1; CE07832; CE07833; DYN1_CAEEL; WBGene00001130; WP:CE07832; WP:CE07833; XQ191; dyn1 WormBase description: dynamin
C13B9.3 C13B9.3 P W All gene names: phi-30; C13B9.3; 3H712; CE01778; COPD_CAEEL; WBGene00015734; WP:CE01778 WormBase description: C13B9.3 encodes a delta subunit of the coatomer (COPI) complex; in mass RNAi assays, C13B9.3 is required for fertility and general health.
C27H6.1 C27H6.1 P W All gene names: apt-10; C27H6.1; 5K448; CE08425; NM_073165; STNB_CAEEL; WBGene00000167; WP:CE08425 WormBase description: apt-10 encodes the C. elegans ortholog of the mammalian Stonins and Drosophila Stoned B, membrane-associated proteins that contain three distinct domains: a proline-rich domain, a stonin homology domain, and a domain paralogous to the mu-adaptin subunits of adaptor protein complexes 1-3; by homology, APT-10 is predicted to regulate the activity of the heteromeric AP-1 and AP-2 clathrin adaptor protein complexes, and thus to play a role in intracellular protein trafficking and endocytosis; in vivo, apt-10 is required for the secretion of EGL-17/FGF, required for sex myoblast migration, from the vulval precursor cell P6.p; loss of apt-10 activity via large-scale RNAi screens, however, does not result in any obvious abnormalities. WormBase CDS description: Adaptor complexes medium subunit family
F02E8.3 F02E8.3 P W All gene names: aps-2; F02E8.3; CE07018; NM_076366; WBGene00000157; WP:CE07018; XF77 WormBase description: The aps-2 gene encodes an adaptin: specifically, it encodes an ortholog of the sigma2 subunit of adaptor protein complex 2 (AP-2), which mediates endocytosis from the plasma membrane; APS-2 appears to be required for embryonic and larval development and for normal body morphology, but is not required for endocytosis of yolk protein in developing oocytes; APS-2 is expressed in nearly all cells during embryogenesis, but during larval and adult stages, expression is confined to neurons and some hypodermal cells, including vulval hypodermal cells during the fourth larval stage. WormBase CDS description: Clathrin coat assembly protein
F26D10.3 F26D10.3 P W All gene names: hsp-1; F26D10.3; F26D10.3.1; F26D10.3.2; F26D10.3.3; T28F3.2; 4S223; CE09682; HSP7A_CAEEL; NM_070667; WBGene00002005; WP:CE09682 WormBase description: hsp-1 encodes hsp70A, a member of the heat shock family of proteins; hsp70A is closely related to the Drosophila heat inducible hsp70s and the S. cerevisiae SSA hsp70 subfamily; the hsp-1 gene is normally expressed throughout development and upon heat-shock the hsp-1 mRNA is enhanced 2-6 fold; down-regulation of hsp-1 via RNA interference results in a small reduction in the life-span of an age-1 mutant indicating that hsp-1 may play some role in regulating longevity. WormBase CDS description: HSP-1 heat shock 70kd protein A
F29G9.3 F29G9.3 P W All gene names: aps-1; apt-2; F29G9.3; 5G505; CE09797; NM_072158; WBGene00000159; WP:CE09797 WormBase description: The apt-2 gene encodes an adaptin: specifically, it encodes an ortholog of the sigma1 subunit of adaptor protein complex 1 (AP-1). WormBase CDS description: clathrin coat assembly protein
F35A5.8 F35A5.8 P W All gene names: erp-1; F35A5.8; CE04492; CE29787; NM_171657; NM_171658; WBGene00001335; WP:CE04492; WP:CE29787; XE420 WormBase description: erp-1 is homologous to the human gene endophilin B1 (also called SH3GLB1, for SH3 domain GRB2-like endophilin B1).
F53H8.1 F53H8.1 P W All gene names: apm-3; apt-7; F53H8.1; CE35723; NM_075783; WBGene00000164; WP:CE35723; XB573 WormBase description: apt-7 gene encodes an adaptin, orthologous to the mu3 subunit of adaptor protein complex 3 (AP-3); APT-7 is also orthologous to human HPS, which when mutated leads to Hermansky-Pudlak syndrome (OMIM:203300); based on structural similarity, APT-7 may be involved in the formation of intracellular transport vesicles. WormBase CDS description: clathrin coat assembly protein
F58G6.1 F58G6.1 P W All gene names: F58G6.1; F58G6.1.1; F58G6.1.2; 4K410; CE03428; WBGene00010272; WP:CE03428 WormBase description: amphiphysin like
JC8.10 JC8.10 P W All gene names: unc-26; unc-48; JC8.10; 4O26; CE28239; CE29050; WBGene00006763; WP:CE28239; WP:CE29050 WormBase description: unc-26 encodes synaptojanin, a polyphosphoinositide phosphatase orthologous to human synaptojanin 1 (OMIM:604297, 309000, which when mutated leads to Lowe oculocerebrorenal syndrome); UNC-26 is required for normal locomotion, pharyngeal pumping, and defecation, and specifically, appears to function in multiple steps of synaptic vesicle recycling; UNC-26 may also play a role in cytoskeletal organization.
R160.1 R160.1 P W All gene names: apm-2; dpy-23; R160.1; R160.1b.1; R160.1b.2; AP2M_CAEEL; CE33813; CE33814; CEAP50; NM_171670; WBGene00001082; WP:CE33813; WP:CE33814; XF13 WormBase description: The dpy-23 gene encodes an adaptin: specifically, it encodes an ortholog of the mu2 subunit of adaptor protein complex 2 (AP-2).
T04D1.3 T04D1.3 P W All gene names: unc-57; T04D1.3; 1F243; CE37042; CE39765; NM_059023; O61843_CAEEL; WBGene00006791; WP:CE37042; WP:CE39765 WormBase description: unc-57 encodes an ortholog of endophilin A that is required for synaptic vesicle endocytosis; UNC-57 is expressed in all neurons, at synapses and neuromuscular junctions, and (weakly) in the spermetheca; like other endophilins, UNC-57 has a large BAR domain, an N-terminal coiled-coil domain within the BAR domain, and a C-terminal SH3 domain; UNC-57 protein is necessary for proper localization of UNC-26 (synaptojanin) protein, which in turn is needed for endocytosis; unc-57 and unc-26 mutants are morphologically, ultrastructurally, and electrophysiologically similar both to one another and to double mutants, indicating that UNC-57 and UNC-26 act in a single genetic pathway.
T05B11.3 T05B11.3 P W All gene names: clic-1; T05B11.3; 5i214; CE13219; WBGene00020246; WP:CE13219
T07A9.6 T07A9.6 P W All gene names: daf-18; T07A9.6; 4B174; CE26385; NM_067525; WBGene00000913; WP:CE26385 WormBase description: daf-18 encodes a lipid phosphatase homologous to the human PTEN tumor suppresor (OMIM:601728, mutated in Cowden disease and several cancers); DAF-18 negatively regulates insulin-like signaling mediated by DAF-2/IR and AGE-1/PI3K and thus plays a role in metabolism, development, and longevity; based on sequence and genetic analysis, DAF-18 is predicted to dephosphorylate AGE-1-generated PIP3 in order to limit activation of the downstream AKT-1 and AKT-2 kinases that negatively regulate DAF-16.
T20B5.1 T20B5.1 P W All gene names: apa-2; apt-4; T20B5.1; T20B5.1.1; T20B5.1.2; CE28680; NM_077171; WBGene00000161; WP:CE28680; XJ961 WormBase description: The apt-4 gene encodes an adaptin: specifically, it encodes an ortholog of the alpha subunit of adaptor protein complex 2 (AP-2). WormBase CDS description: alpha-adaptin
W07A8.3 W07A8.3 P W All gene names: Ce-auxilin; dnj-25; W07A8.3; W07A8.3.1; W07A8.3.2; 5V200; AUXILIN; CE27221; NM_075601; WBGene00001043; WP:CE27221 WormBase description: The dnj-25 (Ce-auxilin) gene is required in vivo for clathrin-mediated endocytosis and for normal development.
Y116A8C.36 Y116A8C.36 P W All gene names: itsn-1; tag-11; Y116A8C.36; 4S71; CE23342; NM_070636; WBGene00006405; WP:CE23342 WormBase description: tag-11/Y116A8C.36 encodes a homolog of human NCF1, which when mutated leads to chronic granulomatous disease (OMIM:306400).
Y71H2B.10 Y71H2B.10 P W All gene names: apb-1; apt-3; Y71H2B.10; 3D674; CE24628; CE29919; CE35137; Q9N4F3_CAEEL; WBGene00000160; WP:CE24628; WP:CE29919; WP:CE35137 WormBase description: The apt-3 gene encodes an adaptin: specifically, it encodes an ortholog of the beta1/2 subunit of adaptor protein complex 1 (AP-1) that affects fertility and embryonic viability.
ZK1248.3 ZK1248.3 P W All gene names: ehs-1; ZK1248.3; 2G113; CE02903; CE32289; NM_062754; WBGene00001224; WP:CE02903; WP:CE32289 WormBase description: The ehs-1 gene encodes an ortholog of mammalian EPS15 that probably functions in endocytosis.