PauliF et al 2006, ST8 germline enriched genes, 1135 genes

Gene list file name:PauliF2006_ST8_1135_germline-enriched
Type of gene identifier:MA primer pair (sjj)
Description:PauliF et al 2006, Sup. Table 8. 1135 genes enriched in the germline. http://elegans.bcgsc.ca/perl/eprofile/index  
Organism:Caenorhabditis elegans (nematode)
Gene list type:Experimental

Gene name             Source Gene ID          Annotation                                                  Date       Added by    

AH10.1 AH10.1 P W All gene names: AH10.1; 5O629; CE07655; WBGene00007082; WP:CE07655 WormBase description: 4-coumarate:coenzyme A ligase
AH6.3 AH6.3 P W All gene names: AH6.3; 2J805; CE01457; WBGene00007081; WP:CE01457; YP23_CAEEL
AH6.5 AH6.5 P W All gene names: mex-6; AH6.5; 2J815; CE26846; MEX6_CAEEL; NM_063642; WBGene00003231; WP:CE26846 WormBase description: mex-6 encodes a CCCH zinc-finger protein highly similar to MEX-5 that functions with MEX-5 to affect embryonic viability, establish soma germline asymmetry in embryos and establish PIE-1, MEX-1, and POS-1 asymmetry in embryos, and also affects formation of intestinal cells; MEX-6 and MEX-5 may act downstream of the PAR proteins. WormBase CDS description: zinc finger protein
B0001.2 B0001.2 P W All gene names: B0001.2; 4M912; CE36776; WBGene00007087; WP:CE36776
B0001.3 B0001.3 P W All gene names: B0001.3; 4M908; CE29523; WBGene00007088; WP:CE29523
B0001.7 B0001.7 P W All gene names: B0001.7; 4M916; CE05145; WBGene00007092; WP:CE05145
B0024.10 B0024.10 P W All gene names: B0024.10; B0024.10.1; B0024.10.2; 5K796; CE05154; WBGene00007100; WP:CE05154
B0024.13 B0024.13 P W All gene names: B0024.13; 5K803; CE05157; CE35376; WBGene00007102; WP:CE05157; WP:CE35376
B0035.12 B0035.12 P W All gene names: B0035.12; B0035.12.1; B0035.12.2; 4M96; CE05167; WBGene00007111; WP:CE05167 WormBase description: polyadenylate-binding protein like
B0205.1 B0205.1 P W All gene names: B0205.1; 1L292; CE34238; CE36908; WBGene00015017; WP:CE34238; WP:CE36908
B0205.9 B0205.9 P W All gene names: B0205.9; 1L299; CE17323; WBGene00015023; WP:CE17323
B0207.11 B0207.11 P W All gene names: B0207.11; 1G538; CE07689; WBGene00015034; WP:CE07689
B0207.7 B0207.7 P W All gene names: B0207.7; 1G522; CE07685; WBGene00015030; WP:CE07685 WormBase description: serine/threonine-protein kinase
B0218.5 B0218.5 P W All gene names: B0218.5; 4I920; CE06688; WBGene00015049; WP:CE06688 WormBase description: ser/thr kinase
B0218.7 B0218.7 P W All gene names: B0218.7; 4I930; CE06690; WBGene00015051; WP:CE06690
B0240.4 B0240.2 P W
B0252.5 B0252.5 P W All gene names: B0252.5; 2H206; CE02421; WBGene00015089; WP:CE02421; YT15_CAEEL
B0261.1 B0261.1 P W All gene names: B0261.1; B0261.1.1; B0261.1.2; 1F835; CE29531; WBGene00015091; WP:CE29531
B0273.2 B0273.2 P W All gene names: puf-7; B0273.2; B0273.2.1; B0273.2.2; 4G253; CE16788; NM_068419; WBGene00004243; WP:CE16788 WormBase description: puf-7 encodes a protein 97% identical to PUF-6 and functions redundantly with the other PUF genes, fbf-1, fbf-2, puf-6, and puf-8, during primordial germ cell development, based on combinatorial RNAi; interacts with NOS-2 in yeast two-hybrid screens.
B0280.5 B0280.5 P W All gene names: B0280.5; 3I192; B028_CAEEL; CE31868; WBGene00015102; WP:CE31868 WormBase description: B0280.5 encodes a protein with a chitin binding peritrophin-A domain that is required, in conjunction with CEJ-1, for early embryonic development; B0280.5 mRNA is expressed specifically in the adult hermaphrodite germ line, is a direct target of GLD-1, and has an RNAi phenotype consistent with the hypothesis that B0280.5 is an effector of GLD-1 in the germline.
B0280.9 B0280.9 P W All gene names: B0280.9; 3I212; CE00816; UTP18_CAEEL; WBGene00015104; WP:CE00816
B0302.3 B0302.3 P W All gene names: B0302.3; WBGene00015120; XR781
B0334.11 B0334.11 P W All gene names: mel-19; ooc-3; B0334.11; 2L784; CE19661; CE32788; NM_064055; NM_182110; WBGene00003868; WP:CE19661; WP:CE32788 WormBase description: ooc-3 encodes a nematode-specific protein with a predicted signal sequence, four predicted transmembrane domains, and two putative PEST sequences; OOC-3 is probably localized to the endoplasmic reticulum (ER), and is maternally required for correct localization of PAR-2 and PAR-3 in the P1 blastomere of the two-cell stage embryo; specifically, OOC-3 is required for restricting PAR-3 to the anterior cortex of the P1 blastomere to assure PAR-2 localization at the posterior cortex; more generally, OOC-3 is required to establish asymmetrical anterior-posterior cortical domains and spindle orientation in P1.
B0379.3 B0379.3 P W All gene names: mut-16; pqn-3; B0379.3; 1K661; CE30474; CE30475; NM_060259; NM_060260; WBGene00003508; WP:CE30474; WP:CE30475 WormBase description: mut-16 encodes a glutamine/asparagine (Q/N)-rich domain-containing protein that lacks obvious homologs outside of other nematode species; MUT-16 activity is required for RNA-mediated interference (RNAi), transgene silencing in germ-line and somatic tissues, and for maintaining low levels of transposon mobilization; MUT-16 is thus predicted to play a role in chromatin organizataion and/or regulation of gene expression.
B0391.10 B0391.10 P W All gene names: B0391.10; 5Q69; CE17338; WBGene00007165; WP:CE17338
B0393.3 B0393.3 P W All gene names: B0393.3; 3F849; CE00856; WBGene00007168; WP:CE00856 WormBase description: Leucine Rich Repeat (2 copies) (2 domains)
B0393.4 B0393.4 P W All gene names: B0393.4; 3F850; CE00857; WBGene00007169; WP:CE00857
B0393.6 B0393.6 P W All gene names: B0393.6; 3F870; CE33964; WBGene00007171; WP:CE33964 WormBase description: Zinc finger, C3HC4 type (RING finger)
B0412.3 B0412.3 P W All gene names: B0412.3; B0412.3.1; B0412.3.2; 3B425; CE03884; WBGene00015173; WP:CE03884
B0414.5 B0414.5 P W All gene names: cpb-3; B0414.5; 1G366; CE07735; CPB3_CAEEL; NM_059279; WBGene00000772; WP:CE07735 WormBase description: cpb-3 encodes a cytoplasmic polyadenylation element binding (CPEB) protein homolog; CPB-3 is dispensable for oogenesis, in contrast to CPEBs in vertebrates (Xenopus), arthropods (Drosophila), and molluscs (Spisula), which all participate in oogenesis. WormBase CDS description: RNA binding protein
B0414.6 B0414.6 P W All gene names: glh-3; B0414.6; 1G370; CE07736; GLH3_CAEEL; NM_059280; WBGene00001600; WP:CE07736 WormBase description: glh-3 encodes a predicted DEAD-like RNA helicase; GLH-3 interacts with itself and with CSN-5, KGB-1, ZYX-1, and GLH-1 in vitro, and is expressed in association with P granules throughout development. WormBase CDS description: RNA helicase
B0414.8 B0414.8 P W All gene names: B0414.8; 1G380; CE30413; CE36910; O01839_CAEEL; WBGene00015176; WP:CE30413; WP:CE36910
B0432.10 B0432.10 P W All gene names: B0432.10; 2A574; CE07748; WBGene00015191; WP:CE07748
B0464.6 B0464.6 P W All gene names: B0464.6; B0464.6.1; B0464.6.2; B0464.6.3; 3K554; CE33965; WBGene00007186; WP:CE33965; YKD6_CAEEL
B0491.6 B0491.6 P W All gene names: B0491.6; B0491.6.1; B0491.6.2; 2L636; CE02108; WBGene00007193; WP:CE02108
B0496.6 B0496.6 P W All gene names: B0496.6; 4I185; CE06718; WBGene00015215; WP:CE06718
B0511.11 B0511.11 P W All gene names: B0511.11; 1L226; CE26852; WBGene00015236; WP:CE26852
B0511.2 B0511.2 P W All gene names: B0511.2; 1L227; CE17341; WBGene00015228; WP:CE17341
B0511.4 B0511.4 P W All gene names: tag-344; B0511.4; 1L223; CE17343; WBGene00015230; WP:CE17343 WormBase description: protein kinase
B0513.9 B0513.9 P W All gene names: B0513.9; B0513.9b.1; B0513.9b.2; 4O626; CE28426; CE39665; WBGene00007200; WP:CE28426; WP:CE39665
B0523.3 B0523.3 P W All gene names: pgl-2; B0523.3; 3J758; CE20462; NM_066510; PGL2_CAEEL; WBGene00003993; WP:CE20462
B0523.5 B0523.5 P W All gene names: CE-FLI-1; ach-1; fli-1; B0523.5; 3J768; CE36522; FLII_CAEEL; NM_066512; WBGene00001443; WP:CE36522 WormBase description: fli-1 encodes a homolog of Drosophila flightless-I; can interact with human Ha-Ras and human actin in vitro; mRNA levels are highest in embryos.
C01B10.8 C01B10.8 P W All gene names: C01B10.8; C01B10.8.1; C01B10.8.2; 4H401; CE06739; Q17539_CAEEL; WBGene00015282; WP:CE06739
C01B10.9 C01B10.9 P W All gene names: C01B10.9; 4H399; CE37181; WBGene00015283; WP:CE37181
C01F6.1 C01F6.1 P W All gene names: C01F6.1; 4J865; CE02950; Q17559_CAEEL; WBGene00007221; WP:CE02950
C01F6.4 C01F6.4 P W All gene names: fem-3; C01F6.4; 4J871; CE02953; FEM3_CAEEL; NM_069186; WBGene00001413; WP:CE02953 WormBase description: fem-3 encodes a novel protein that promotes male development in all tissues. WormBase CDS description: sex-determining protein (FEM-3)
C01G10.10 C01G10.10 P W All gene names: C01G10.10; 5P562; CE20480; WBGene00007237; WP:CE20480 WormBase description: O-sialoglycoprotein endopeptidase
C01G10.7 C01G10.7 P W All gene names: C01G10.7; 5P567; CE07816; WBGene00007234; WP:CE07816 WormBase description: citrate lyase beta chain
C01G12.2 C01G12.2 P W All gene names: nspb-7; C01G12.2; 2O863; CE38585; WBGene00007243; WP:CE38585
C01G5.3 C01G5.3 P W All gene names: C01G5.3; 4H301; CE06749; WBGene00015305; WP:CE06749
C01G5.4 C01G5.4 P W All gene names: C01G5.4; 4H299; CE23512; WBGene00015306; WP:CE23512
C01G6.3 C01G6.3 P W All gene names: C01G6.3; 2J561; CE37474; WBGene00007225; WP:CE37474
C01H6.5 C01H6.5 P W All gene names: cnr-3; nhr-23; C01H6.5; C01H6.5b.1; C01H6.5b.2; C01H6.5b.3; C01H6.5e.1; C01H6.5e.2; C01H6.5f.1; C01H6.5f.2; 1H797; CE24775; CE30478; CE37806; CE39084; CE39085; CE39086; NHR23_CAEEL; WBGene00003622; WP:CE24775; WP:CE30478; WP:CE37806; WP:CE39084; WP:CE39085; WP:CE39086; chr3 WormBase description: The nhr-23 gene encodes a nuclear hormone receptor homolog that is required in all larval molts; NHR-23 is highly similar to Drosophila DHR3, an ecdysone-inducible gene product involved in metamorphosis; NHR-23 is required for hypodermal expression of acn-1 and, probably, of dpy-7.
C01H6.9 C01H6.9 P W All gene names: C01H6.9; 1H806; CE07824; WBGene00007258; WP:CE07824 WormBase description: C01H6.9 encodes a homolog of haploid germ cell-specific nuclear protein kinase (haspin) that specifically binds GOA-1 in yeast two-hybrid assays; C01H6.9 is expressed in PHB sensory neurons and PVT interneurons in the tail, several unidentified neurons in the head (with projections to the nose and nerve ring), and intestinal cells, with mainly nuclear localization; C01H6.9 has no obvious function or phenotype in RNAi assays, either alone or with inactivation of a close paralog (F22H10.5). WormBase CDS description: Eukaryotic protein kinase domain
C02B8.1 C02B8.1 P W All gene names: C02B8.1; C02B8.1.1; C02B8.1.2; CE33514; WBGene00015320; WP:CE33514; XI767; YWZ1_CAEEL
ZK688.9 C02C2.6 P W
C02F5.2 C02F5.2 P W All gene names: C02F5.2; 3J339; CE00038; WBGene00015345; WP:CE00038; YKK2_CAEEL
C02G6.2 C02G6.2 P W All gene names: C02G6.2; 5G353; CE35214; WBGene00015360; WP:CE35214 WormBase description: peptidase
C03A7.9 C03A7.9 P W All gene names: srt-64; C03A7.9; 5F642; CE37951; NM_071985; WBGene00015367; WP:CE37951 WormBase description: 7TM chemoreceptor, srt family
C03C10.3 C03C10.3 P W All gene names: rnr-2; C03C10.3; C03C10.3.1; C03C10.3.2; C03C10.3.3; 3F184; CE00874; NM_065420; RIR2_CAEEL; WBGene00004392; WP:CE00874 WormBase description: Ribonuclease-diphosphate reductase M2
C03E10.4 C03E10.4 P W All gene names: gly-20; C03E10.4; 5L765; CE26613; GnT II; MGAT2; NM_073463; WBGene00001645; WP:CE26613 WormBase description: gly-20 is orthologous to the human gene MANNOSYL (ALPHA-1,6-)-GLYCOPROTEIN BETA-1,2-N-ACETYLGLUCOSAMINYLTRANSFERASE (MGAT2; OMIM:602616), which when mutated leads to carbohydrate-deficient glycoprotein syndrome, type II. WormBase CDS description: UDP-GlcNAc:a-6-D-mannoside b1,2-N-acetylglucosaminyltransferase II
C03G6.6 C03G6.6 P W All gene names: C03G6.6; 5H837; CE36265; WBGene00015394; WP:CE36265
C04A2.3 C04A2.2 P W
C04B4.2 C04B4.2 P W All gene names: C04B4.2; CE05204; WBGene00007290; WP:CE05204; XM903
C04E6.11 C04E6.11 P W All gene names: C04E6.11; 5G396; CE36911; WBGene00015425; WP:CE36911
C04E6.4 C04E6.4 P W All gene names: C04E6.4; 5G387; CE35222; WBGene00015421; WP:CE35222
C04E6.5 C04E6.5 P W All gene names: C04E6.5; 5G383; CE27053; WBGene00015422; WP:CE27053
C04G2.5 C04G2.5 P W All gene names: C04G2.5; 4K858; CE05213; WBGene00007306; WP:CE05213
C04G6.4 C04G6.4 P W All gene names: C04G6.4; 2F372; CE32112; WBGene00015454; WP:CE32112 WormBase description: salt-stress induced peptide
C04H5.6 C04H5.6 P W All gene names: mog-4; C04H5.6; 2O840; CE15592; DHX16_CAEEL; NM_064626; WBGene00003392; WP:CE15592 WormBase description: The mog-4 gene encodes a DEAH helicase orthologous to the Drosophila CG10689 and the S. cerevisiae PRP2 proteins. WormBase CDS description: Helicases conserved C-terminal domain
C05C10.5 C05C10.5 P W All gene names: C05C10.5; C05C10.5c.1; C05C10.5c.2; C05C10.5c.3; 2K235; CE01469; CE35822; CE39217; WBGene00007332; WP:CE01469; WP:CE35822; WP:CE39217; YQ15_CAEEL
C05C12.5 C05C12.5 P W All gene names: C05C12.5; 4M24; CE02968; WBGene00007337; WP:CE02968
C05C8.4 C05C8.4 P W All gene names: gei-6; C05C8.4; 5H708; CE07922; NM_072435; WBGene00001563; WP:CE07922
C05C8.5 C05C8.5 P W All gene names: C05C8.5; 5H714; CE07923; WBGene00015462; WP:CE07923
C05C8.6 C05C8.6 P W All gene names: C05C8.6; 5H716; CE07924; O16313_CAEEL; WBGene00015463; WP:CE07924
C05D2.10 C05D2.6 P W
C06A1.1 C06A1.1 P W All gene names: cdc-48.1; phi-31; C06A1.1; 2K850; CE02114; NM_063872; TERA1_CAEEL; WBGene00007352; WP:CE02114 WormBase description: transitional endoplasmic reticulum ATPase homolog 1 (P97 protein)
F58G1.1 C06A1.4 P W
C06A5.3 C06A5.3 P W All gene names: C06A5.3; 1G565; CE37699; CE37700; WBGene00015501; WP:CE37699; WP:CE37700
C06A5.6 C06A5.6 P W All gene names: C06A5.6; 1G560; CE07953; WBGene00015504; WP:CE07953
C06A5.9 C06A5.9 P W All gene names: rnf-1; tag-54; C06A5.9; 1G586; CE34249; NM_059337; O01482_CAEEL; WBGene00004380; WP:CE34249
C06A8.5 C06A8.5 P W All gene names: C06A8.5; 2I73; CE02456; Q17695_CAEEL; WBGene00015515; WP:CE02456
C06C6.7 C06C6.7 P W All gene names: C06C6.7; 5Q469; CE15601; WBGene00007381; WP:CE15601
C06G3.10 C06G3.10 P W All gene names: cgo-2; cogc-2; C06G3.10; 4H802; CE28817; CELDLC; COG2_CAEEL; NM_068691; WBGene00000585; WP:CE28817; cog2 WormBase description: cogc-2 encodes an ortholog of mammalian COG-2, a subunit of lobe A of the conserved oligomeric Golgi complex (COGC); COGC-2 is required for normal gonadal distal tip cell migration, a process that also requires seven other orthologs of COGC subunits; like other lobe A subunits in both C. elegans and S. cerevisiae, COGC-2 is strongly required for normal function, while lobe B subunits are only partially required in either worms or yeast.
C06G8.4 C06G8.4 P W All gene names: srd-7; C06G8.4; 4L550; CE05232; NM_069600; SRD7_CAEEL; WBGene00005085; WP:CE05232 WormBase description: 7TM chemoreceptor (srd-family)
C07E3.4 C07E3.4 P W All gene names: C07E3.4; 2K653; CE02120; WBGene00007415; WP:CE02120 WormBase description: Protein-tyrosine phosphatase
C07G2.1 C07G2.1 P W All gene names: cej-1; C07G2.1; C07G2.1a.1; C07G2.1a.2; 3F579; CE00665; CE33971; CEJ1_CAEEL; WBGene00000465; WP:CE00665; WP:CE33971 WormBase description: cej-1 encodes a protein with a chitin binding peritrophin-A domain that is required, in conjunction with B0280.5, for early embryonic development; cej-1 mRNA is expressed specifically in the adult hermaphrodite germ line, is a direct target of GLD-1, and has an RNAi phenotype consistent with the hypothesis that CEJ-1 is an effector of GLD-1 in the germline.
C07H6.5 C07H6.5 P W All gene names: cgh-1; C07H6.5; C07H6.5.1; C07H6.5.2; 3I586; CE00839; CGH1_CAEEL; NM_066245; WBGene00000479; WP:CE00839 WormBase description: The ortholog of a RNA helicase ste13/ME31B/RCK/p54 that is required for oocyte and sperm function and the prevention of physiological germline-associated apoptosis; it is expressed in the early embryo and germline and localizes to P granules. WormBase CDS description: ATP-dependent RNA helicase
C08B11.6 C08B11.6 P W All gene names: C08B11.6; C08B11.6.1; C08B11.6.2; ARP6_CAEEL; CE30856; WBGene00007434; WP:CE30856 WormBase description: actin
C08B6.7 C08B6.7 P W All gene names: C08B6.7; 5K612; CE05244; WBGene00007428; WP:CE05244 WormBase description: 59 protein
C08C3.2 C08C3.2 P W All gene names: bath-15; C08C3.2; 3I864; BAT15_CAEEL; CE39087; WBGene00015590; WP:CE39087
C08H9.8 C08H9.8 P W All gene names: C08H9.8; 2K140; CE36468; WBGene00007468; WP:CE36468 WormBase description: tyrosine-protein kinase (2 domains)
C09B9.3 C09B9.3 P W All gene names: C09B9.3; 4F786; CE29571; WBGene00015628; WP:CE29571; YAVK_CAEEL
C09B9.7 C09B9.7 P W All gene names: C09B9.7; 4F822; CE06799; WBGene00015630; WP:CE06799
C09G5.7 C09G5.7 P W All gene names: C09G5.7; 2L5; CE01487; WBGene00007489; WP:CE01487; YQ37_CAEEL
C09H6.3 C09H6.3 P W All gene names: mau-2; C09H6.3; 1I705; CE15611; NM_059827; WBGene00003136; WBGene00007498; WP:CE15611
C10H11.1 C10H11.1 P W All gene names: C10H11.1; 1F327; CE29081; WBGene00015691; WP:CE29081
C10H11.7 C10H11.7 P W All gene names: C10H11.7; CE08096; WBGene00015696; WP:CE08096
C13A2.4 C13A2.4 P W All gene names: C13A2.4; 5H753; CE08116; WBGene00015721; WP:CE08116
C13B4.2 C13B4.2 P W All gene names: usp-14; C13B4.2; C13B4.2.1; C13B4.2.2; 2O772; CE15615; NM_064605; UBP14_CAEEL; WBGene00006856; WP:CE15615 WormBase description: usp-14 encodes a homolog of ubiquitin-specific protease 14 (Usp14), a highly conserved thiol protease that hydrolyzes the peptide bond at the C-terminal glycine of ubiquitin (OMIM:607274, mutations are associated with synaptic defects in ataxia mice); by homology, USP-14 is predicted to function in ubiquitin-mediated protein degradation, or regulation of protein localization or activity; as loss of USP-14 function via RNA-mediated interference (RNAi) does not result in any abnormalities, the precise role of USP-14 in C. elegans development and/or behavior is not yet known. WormBase CDS description: Queuine trna-ribosyltransferase
C13G3.3 C13G3.3 P W All gene names: C13G3.3; C13G3.3a.1; C13G3.3a.2; C13G3.3b.1; C13G3.3b.2; 5L508; CE05279; CE20505; WBGene00007554; WP:CE05279; WP:CE20505 WormBase description: proteion phosphatase
C14A4.13 C14A4.13 P W All gene names: C14A4.13; 2K909; CE02142; WBGene00007563; WP:CE02142 WormBase description: serine/threonine kinase
C14A4.3 C14A4.3 P W All gene names: C14A4.3; CE32796; NM_063881; WBGene00007556; WP:CE32796; YTH3_CAEEL
C14A4.4 C14A4.4 P W All gene names: crn-3; C14A4.4; 2K881; CE02145; CE32797; NM_063882; NM_182164; WBGene00000796; WP:CE02145; WP:CE32797 WormBase description: crn-3 encodes a cell death-related nuclease, homologous to the 100 kDa polymyositis/scleroderma autoantigen (PM/Scl-100), that is required for normal levels of DNA degradation during apoptosis; PM/Scl-100 is a ribonuclease component of the multiexonuclease exosome complex, which processes or degrades several types of RNAs in yeast; crn-3(RNAi) animals show retarded growth and a low penetrance of embryonic lethality; CRN-3 promotes both DNA degradation and cell corpse engulfment, in a partially redundant pathway that includes CRN-2 but is parallel to CPS-6; CRN-3 is predicted to be mitochondrial.
C14A6.7 C14A6.7 P W All gene names: C14A6.7; 5S646; CE18498; WBGene00007571; WP:CE18498
C14B1.4 C14B1.4 P W All gene names: C14B1.4; 3E795; CE00901; WBGene00007575; WP:CE00901; YKY4_CAEEL WormBase description: tag-125/C14B1.4 encodes an ortholog of the histone methyltransferase subunit WDR5 (OMIM:609012) that antagonizes SynMuv transcriptional repressors. WormBase CDS description: guanine nucleotide binding protein
C14B1.7 C14B1.7 P W All gene names: C14B1.7; 3E810; WBGene00007578
C14B1.9 C14B1.9 P W All gene names: C14B1.9; 3E814; CE00906; WBGene00007580; WP:CE00906
C14C11.6 C14C11.6 P W All gene names: mut-14; C14C11.6; 5G140; CE06825; NM_072089; WBGene00003507; WP:CE06825 WormBase description: mut-14 mutants exhibit germline transposon activation, a deficient response to RNAi, resistance to co-suppression, and transgene desilencing. WormBase CDS description: helicase
C15C6.4 C15C6.4 P W All gene names: C15C6.4; 1M805; CE18505; WBGene00007603; WP:CE18505
C15H11.5 C15H11.5 P W All gene names: tag-338; C15H11.5; 5O899; CE08182; WBGene00007615; WP:CE08182
C15H11.6 C15H11.6 P W All gene names: nxf-2; C15H11.6; 5O896; CE36102; NM_074167; NXF2_CAEEL; WBGene00003835; WP:CE36102 WormBase description: nxf-2 encodes a predicted homolog of human TAP protein, a member of the NXF family of shuttling transport receptors for nuclear export of mRNA, and it affects embryonic viability.
C16A11.4 C16A11.4 P W All gene names: C16A11.4; 2E519; CE34688; WBGene00015817; WP:CE34688
C16A11.7 C16A11.7 P W All gene names: C16A11.7; 2E546; CE34690; WBGene00015820; WP:CE34690
C16C10.6 C16C10.6 P W All gene names: C16C10.6; 3F258; CE01497; WBGene00007627; WP:CE01497; YQ56_CAEEL
C16C8.16 C16C8.16 P W All gene names: C16C8.16; 2D737; CE08227; WBGene00015853; WP:CE08227
C16D9.5 C16D9.5 P W All gene names: C16D9.5; 5I722; CE35239; WBGene00015860; WP:CE35239
C17D12.6 C17D12.6 P W All gene names: spe-9; C17D12.6; 1M176; CE27074; NM_060554; WBGene00004963; WP:CE27074 WormBase description: spe-9 encodes a predicted plasma membrane protein with a short intracellular domain and external EGF-like repeats most closely resembling those of the Delta, Serrate, APX-1, and LAG-2 signaling ligands; SPE-9 is required autonomously in sperm for fertilization, and by homology, likely mediates an adhesive or signaling event necessary for proper oocyte fertilization; spe-9 mRNA is detected solely in animals that are engaged in spermatogenesis; the receptor for SPE-9 is not yet known. WormBase CDS description: EGF-like domain (2 domains)
C17E4.1 C17E4.1 P W All gene names: C17E4.1; 1J982; CE39896; WBGene00007641; WP:CE39896
C17E4.3 C17E4.3 P W All gene names: C17E4.3; 1J994; CE37199; WBGene00007643; WP:CE37199
C17E7.4 C17E7.4 P W All gene names: C17E7.4; 5E371; CE08264; O16393_CAEEL; WBGene00015899; WP:CE08264
C17F3.3 C17F3.3 P W All gene names: C17F3.3; 1H257; CE17414; WBGene00015908; WP:CE17414
C17G10.4 C17G10.4 P W All gene names: cdc-14; C17G10.4; C17G10.4c.1; C17G10.4c.2; 2F878; CDC14_CAEEL; CE06845; CE08287; CE08288; CE30868; CE36916; NM_062683; WBGene00000383; WP:CE06845; WP:CE08287; WP:CE08288; WP:CE30868; WP:CE36916; cdc14 WormBase description: cdc-14 encodes a dual-specificity phosphatase, homologous to Cdc14p in S. cerevisiae; CDC-14 localizes to the central spindle in anaphase and to the midbody in telophase, and is required for cytokinesis and embryonic viability.
C17H11.4 C17H11.4 P W All gene names: C17H11.4; CE08292; WBGene00015924; WP:CE08292; XI800
C18A3.1 C18A3.1 P W All gene names: C18A3.1; 2G11; CE01793; WBGene00015939; WP:CE01793
C18A3.2 C18A3.2 P W All gene names: C18A3.2; 2G9; CE27707; WBGene00015940; WP:CE27707
C18A3.5 C18A3.5 P W All gene names: C18A3.5; C18A3.5e.1; C18A3.5e.2; C18A3.5f.1; C18A3.5f.2; C18A3.5f.3; C18A3.5f.4; C18A3.5f.5; 2G2; CE27708; CE27709; CE27710; CE32130; CE32131; WBGene00015943; WP:CE27708; WP:CE27709; WP:CE27710; WP:CE32130; WP:CE32131 WormBase description: RNA binding protein
C18E3.5 C18E3.5 P W All gene names: C18E3.5; 1E771; CE27713; WBGene00015974; WP:CE27713 WormBase description: beta transducin
C18E3.8 C18E3.8 P W All gene names: hop-1; C18E3.8; 1E778; CE08317; HOP1_CAEEL; NM_058927; WBGene00001985; WP:CE08317 WormBase description: seven trans-membrane protein
C18E9.3 C18E9.3 P W All gene names: pqn-14; C18E9.3; C18E9.3c.1; C18E9.3c.2; C18E9.3c.3; 2J258; CE20519; CE32804; CE38277; NM_063508; NM_063509; WBGene00004105; WP:CE20519; WP:CE32804; WP:CE38277 WormBase description: The protein product of this gene is predicted to contain a glutamine/asparagine (Q/N)-rich ('prion') domain, by the algorithm of Michelitsch and Weissman (as of the WS77 release of WormBase, i.e., in wormpep77).
C18E9.8 C18E9.8 P W All gene names: C18E9.8; 2J276; CE05300; WBGene00007688; WP:CE05300 WormBase description: C18E9.8 is orthologous to the human gene JOINED TO JAZF1 (JJAZ1; OMIM:606245), which when mutated leads to disease.
C18F10.7 C18F10.7 P W All gene names: C18F10.7; C18F10.7a.1; C18F10.7a.2; 3H366; CE00784; CE30608; WBGene00015978; WP:CE00784; WP:CE30608
C18G1.4 C18G1.4 P W All gene names: pgl-3; tag-136; C18G1.4; 5F235; CE17420; CE27717; NM_071877; NM_071878; WBGene00003994; WBGene00015983; WP:CE17420; WP:CE27717
K06B9.4 C18H2.2 P W
C18H2.5 C18H2.3 P W
C18H7.4 C18H7.4 P W All gene names: C18H7.4; 4B347; CE17429; WBGene00015994; WP:CE17429 WormBase description: protein kinase
C23G10.4 C23G10.4 P W All gene names: rpn-2; C23G10.4; C23G10.4a.1; C23G10.4a.2; C23G10.4a.3; 3H291; CE31310; CE31311; NM_065945; NM_065946; PSMD1_CAEEL; WBGene00004459; WP:CE31310; WP:CE31311 WormBase description: rpn-2 encodes a non-ATPase subunit of the 26S proteasome's 19S regulatory paritcle (RP) base subcomplex; RPN-2 is required for embryonic, larval, and germline development and by homology, is predicted to function in unfolding and recognition of protein substrates and/or recycling of ubiquitin moieties during protein degradation; RPN-2 is expressed sporadically at all stages of development in the pharynx, intestine, body wall muscle, somatic gonad, neurons, and hypodermis. WormBase CDS description: tRNA processing protein SEN3
C23G10.5 C23G10.5 P W All gene names: C23G10.5; 3H281; CE39897; WBGene00016012; WP:CE39897
C23G10.7 C23G10.7 P W All gene names: C23G10.7; C23G10.7a.1; C23G10.7a.2; 3H286; CE38937; CE38938; CE38939; U383_CAEEL; WBGene00016014; WP:CE38937; WP:CE38938; WP:CE38939
C23G10.8 C23G10.8 P W All gene names: C23G10.8; C23G10.9; 3H292; CE25784; Q9GYR5_CAEEL; WBGene00016015; WP:CE25784 WormBase description: S. pombe adenylyl cyclase-associated protein (weak)
C24F3.4 C24F3.4 P W All gene names: C24F3.4; 4K980; CE18521; WBGene00007698; WP:CE18521
C24G6.1 C24G6.1 P W All gene names: syp-2; C24G6.1; 5G17; CE17456; NM_072061; WBGene00006376; WP:CE17456
C25A11.1 C25A11.1 P W All gene names: C25A11.1; CE37203; WBGene00016086; WP:CE37203; XJ741
C25A8.1 C25A8.1 P W All gene names: C25A8.1; 4H777; CE08382; WBGene00016082; WP:CE08382 WormBase description: truncated MSP
C25D7.12 C25D7.12 P W All gene names: C25D7.12; 5P513; CE08397; WBGene00007721; WP:CE08397
C25D7.3 C25D7.3 P W All gene names: dpy-29; sdc-3; C25D7.3; 5P520; CE08389; NM_074302; SDC3_CAEEL; WBGene00004747; WP:CE08389 WormBase description: sdc-3 encodes a protein that contains two mutationally separable domains: a zinc finger motif required for dosage compensation and a myosin- like putative ATP- binding region required for her-1 regulation of sex determination; SDC-3 activates dosage compensation by directing the dosage compensation protein complex to the hermaphrodite X chromosomes, and is functionally redundant with SDC-2 with respect to dosage compensation; SDC-1, SDC-2, and SDC-3 proteins form a complex. WormBase CDS description: Zinc finger, C2H2 type
C25G4.4 C25G4.4 P W All gene names: tag-347; C25G4.4; 4N218; CE05305; Q18171_CAEEL; WBGene00007732; WP:CE05305 WormBase description: SAND domain
C25H3.6 C25H3.6 P W All gene names: C25H3.6; 2F953; CE27094; CE31315; CE36525; WBGene00016115; WP:CE27094; WP:CE31315; WP:CE36525
C26B2.2 C26B2.2 P W All gene names: C26B2.2; 4I786; CE04088; WBGene00016125; WP:CE04088
C26C6.6 C26C6.6 P W All gene names: C26C6.6; 1I81; CE05315; WBGene00007740; WP:CE05315 WormBase description: lim domains
C26D10.1 C26D10.1 P W All gene names: ran-3; C26D10.1; 2I614; CE03024; NM_063352; RCC1_CAEEL; WBGene00004304; WP:CE03024 WormBase description: regulator of chromosome condensation
C26E6.3 C26E6.3 P W All gene names: C26E6.3; C26E6.3.1; C26E6.3.2; 3G35; CE32144; WBGene00016139; WP:CE32144 WormBase description: cell differentiation family, Rcd1-like
C26E6.4 C26E6.4 P W All gene names: phi-14; rpb-2; C26E6.4; 3G33; CE01162; NM_065646; RPB2_CAEEL; WBGene00016140; WP:CE01162 WormBase description: DNA-directed RNA polymerase II
C26E6.5 C26E6.5 P W All gene names: fsn-1; C26E6.5; 3G27; CE01163; FBSP1_CAEEL; NM_065645; WBGene00001499; WBGene00016141; WP:CE01163 WormBase description: This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins
C27A12.3 C27A12.3 P W All gene names: tag-146; C27A12.3; 1G615; CE38999; WBGene00006492; WP:CE38999 WormBase description: zinc finger protein
C27A12.6 C27A12.6 P W All gene names: C27A12.6; 1G630; CE08415; WBGene00016156; WP:CE08415
C27A12.7 C27A12.7 P W All gene names: C27A12.7; C27A12.7a.1; C27A12.7a.2; C27A12.7b.1; C27A12.7b.2; C27A12.7b.3; C27A12.7b.4; C27A12.7b.5; C27A12.7b.6; 1G634; CE08416; CE32810; WBGene00016157; WP:CE08416; WP:CE32810
C27A2.6 C27A2.6 P W All gene names: dsh-2; C27A2.6; 2F370; CE27097; NM_062536; Q18239_CAEEL; WBGene00001102; WP:CE27097 WormBase description: dsh-2 encodes a protein containing a DIX domain, a DEP domain, and a PDZ domain that is required for embryonic viability and functions in Wnt pathway signaling between the embryonic blastomeres P2 and EMS with respect to endoderm specification and to orient the division axis of the EMS cell; expressed from the four-cell embryo stage, and is primarily associated with membranes.
C27B7.4 C27B7.4 P W All gene names: C27B7.4; 4J665; CE17477; Q18241_CAEEL; WBGene00007761; WP:CE17477 WormBase description: DNA repair protein
C27D9.1 C27D9.1 P W All gene names: C27D9.1; 2F45; CE06891; WBGene00016163; WP:CE06891
C27F2.10 C27F2.7 P W
C27H2.2 C27H2.3 P W
C27H5.6 C27H5.6 P W All gene names: C27H5.6; 2H474; CE34715; WBGene00016175; WP:CE34715
C27H6.2 C27H6.2 P W All gene names: ruvb-1; C27H6.2; 5K460; CE08426; NM_073166; O17607_CAEEL; WBGene00007784; WP:CE08426 WormBase description: Yeast hypothetical 50.5 KD protein like
C28A5.2 C28A5.2 P W All gene names: C28A5.2; 3F526; CE00676; WBGene00007789; WP:CE00676
C28C12.11 C28C12.11 P W All gene names: C28C12.11; 4J239; CE29192; WBGene00016181; WP:CE29192
C28D4.7 C28D4.4 P W
C28D4.8 C28D4.5 P W
C29A12.1 C29A12.1 P W All gene names: C29A12.1; 5L292; CE05326; WBGene00007797; WP:CE05326
C29E4.4 C29E4.4 P W All gene names: npp-15; C29E4.4; 3J21; CE37484; CeNup133; NM_066323; NU133_CAEEL; WBGene00003801; WP:CE37484
C29E6.3 C29E6.3 P W All gene names: pph-2; pph2A-c; C29E6.3; 4M640; CE17478; NM_069850; WBGene00004084; WP:CE17478 WormBase description: protein tyrosine phosphatase
C29F5.3 C29F5.3 P W All gene names: C29F5.3; 2G580; CE02510; WBGene00016212; WP:CE02510
C29H12.5 C29H12.5 P W All gene names: C29H12.5; 2G400; CE02518; WBGene00016236; WP:CE02518
C30B5.1 C30B5.1 P W All gene names: tag-319; C30B5.1; 2G491; CE37325; Q18320_CAEEL; WBGene00016243; WP:CE37325
C30B5.3 C30B5.3 P W All gene names: cpb-2; C30B5.3; 2G485; CE34717; CPB2_CAEEL; NM_062835; WBGene00000771; WP:CE34717 WormBase description: cpb-2 encodes a cytoplasmic polyadenylation element binding (CPEB) protein homolog, expressed specifically in the spermatogenic germ line; CPB-2 is dispensable for oogenesis, in contrast to CPEBs in vertebrates (Xenopus), arthropods (Drosophila), and molluscs (Spisula), which all participate in oogenesis. WormBase CDS description: C. elegans protein C40H1.1
ZK1236.7 C30C11.3 P W
C30G12.1 C30G12.1 P W All gene names: C30G12.1; 2H591; CE29685; WBGene00016273; WP:CE29685; YQB1_CAEEL
C30G12.7 C30G12.7 P W All gene names: puf-8; C30G12.7; 2H586; CE37486; NM_063122; WBGene00004244; WP:CE37486
C31E10.2 C31E10.2 P W All gene names: C31E10.2; CE08502; WBGene00007843; WP:CE08502; XO600 WormBase description: reverse transcriptase
C31H1.8 C31H1.8 P W All gene names: C31H1.8; 4G576; CE27808; WBGene00016291; WP:CE27808
C32C4.3 C32C4.3 P W All gene names: C32C4.3; 5L124; CE37878; WBGene00007863; WP:CE37878
C32D5.3 C32D5.3 P W All gene names: C32D5.3; 2G608; CE01843; EFR3_CAEEL; WBGene00016311; WP:CE01843 WormBase description: C32D5.3 encodes an ortholog of ROLLING BLACKOUT (RBO; also called CMP44E or STAMPHA), a eukaryotic protein required for sustained phospholipase C activity during Drosophila phototransduction; RBO homologs have two predicted transmembrane helices, are significantly similar to several acylglycerol lipases, and share motifs characteristic of carboxyesterases and lipases.
C32E8.8 C32E8.8 P W All gene names: ptr-2; C32E8.8; 1E358; CE08532; NM_058820; WBGene00004217; WP:CE08532 WormBase description: ptr-2 encodes an ortholog of Drosophila and human PTCHD3, which defines one of seven paralogous families of sterol sensing domain (SSD) proteins; PTR-2 is required for cytokinesis in somatic cells, but not in the germline (the converse of PTC-1's function); PTR-2 is partially required for normal molting from L4 to adult stages; PTR-2 is also required for normal male tail development, growth to full size, locomotion, and viability.
C32F10.2 C32F10.2 P W All gene names: lin-35; C32F10.2; 1G391; CE24823; NM_059285; WBGene00003020; WP:CE24823 WormBase description: lin-35 encodes the C. elegans retinoblastoma protein (Rb) ortholog; lin-35 was first identified in screens for synthetic multivulva (synMuv) genes and as a class B synMuv gene, functions redundantly with class A genes to antagonize Ras signaling and negatively regulate vulval development; in addition, lin-35 activity is required redundantly with: 1) pha-1 and ubc-18 for early steps in pharyngeal morphogenesis, 2) fzr-1 for normal patterns of postembryonic proliferation, 3) xnp-1 for somatic gonad development, and 4) psa-1 for fertility and embryonic and larval development; on its own, lin-35 is also required for wild-type levels of fertility; LIN-35 is expressed broadly in embryos and L1 larvae, but in later larvae and adults is detected in vulval precursor cells and their descendants as well as a subset of head and tail cells.
C32F10.5 C32F10.5 P W All gene names: hmg-3; C32F10.5; 1G392; CE08542; NM_059287; SSP1B_CAEEL; WBGene00001973; WP:CE08542 WormBase description: single-strand recognition protein
C33A12.15 C33A12.15 P W All gene names: C33A12.15; 4K268; CE35419; WBGene00007888; WP:CE35419 WormBase description: Transthyretin-like family
C33F10.10 C33F10.10 P W All gene names: C33F10.10; WBGene00043172
C33H5.4 C33H5.4 P W All gene names: klp-10; C33H5.4; 4I565; CE04148; CE34733; WBGene00002221; WP:CE04148; WP:CE34733 WormBase description: klp-10 encodes a predicted kinesin motor protein that while similar to the Xenopus and human klp2 kinesins, lacks the switch I motif critical for interaction with ATP; although RNAi experiments purportedly targeting klp-10 result in meiotic defects and embryonic lethality, loss of klp-10 activity via a deletion allele results in no obvious abnormalities, suggesting that the reported RNAi phenotypes are due to targeting of the highly similar klp-18 gene; klp-10 expression levels appear to be below the level of detection of RT-PCR, Northern, and Western analyses.
C34B7.2 C34B7.2 P W All gene names: C34B7.2; 1I917; CE32316; WBGene00007912; WP:CE32316 WormBase description: Yeast hypothetical protein YNOD like
C34D4.10 C34D4.10 P W All gene names: C34D4.10; 4H882; CE17504; WBGene00016402; WP:CE17504
C34E10.5 C34E10.5 P W All gene names: tag-251; C34E10.5; C34E10.5.1; C34E10.5.2; C34E10.5.3; 3G323; CE29033; TG251_CAEEL; WBGene00016408; WP:CE29033
C34F11.2 C34F11.2 P W All gene names: C34F11.2; 2F501; CE04163; WBGene00016414; WP:CE04163
C34G6.7 C34G6.7 P W All gene names: pqn-19; C34G6.7; C34G6.7a.1; C34G6.7a.2; C34G6.7b.1; C34G6.7b.2; 1G480; CE29700; CE32816; NM_059309; NM_182013; WBGene00004109; WP:CE29700; WP:CE32816 WormBase description: The protein product of this gene is predicted to contain a glutamine/asparagine (Q/N)-rich ('prion') domain, by the algorithm of Michelitsch and Weissman (as of the WS77 release of WormBase, i.e., in wormpep77).
C35D10.7 C35D10.7 P W All gene names: C35D10.7; C35D10.7b.1; C35D10.7b.2; 3F947; CE32160; CE32161; WBGene00016444; WP:CE32160; WP:CE32161
C35D10.9 C35D10.9 P W All gene names: ced-4; C35D10.9; 3F943; CE01203; CE38154; CED4_CAEEL; WBGene00000418; WP:CE01203; WP:CE38154 WormBase description: ced-4 encodes a novel protein; along with CED-3, CED-4 is required for the initiation of programmed cell death; accordingly, genetic analyses indicate that ced-3 and ced-4 function upstream of ced-1, ced-2, and nuc-1 in the programmed cell death pathway; in yeast two-hybrid experiments, and upon coexpression in mammalian cells, CED-4 interacts with CED-9, an anti-apoptotic BCL-2 homolog; coexpression of CED-4 and CED-9 results in redistribution of CED-4 from the cytosol to organellar membranes, suggesting that CED-9 may negatively regulate CED-4 activity by sequestering CED-4 to intracellular membranes.
C36A4.8 C36A4.8 P W All gene names: brc-1; C36A4.8; 3E944; CE31438; NM_065379; WBGene00000264; WP:CE31438 WormBase description: The brc-1 gene encodes a homolog of human BRCA1 (mutated in early onset breast and ovarian cancer; OMIM:113705); BRC-1 forms a heterodimer with BRD-1, which constitutes an E3 ubiquitin ligase; after irradiation, the DNA checkpoint proteins ATL-1 and MRE-11 are required for BRC-1/BRD-1 heterodimers to associate with the E2 ubiqutin-conjugating enzyme LET-70/Ubc5 and with RAD-51, and to ubiquitylate damaged chromatin; brc-1(RNAi) animals have excess chromosomal nondisjunction, abnormally high levels of CEP-1-dependent germ cell apoptosis (both with and without gamma-irradiation) and hypersensitivity to gamma-irradiation (e.g., abnormal sterility after irradiation); BRC-1 and BRD-1 bind one another, probably through their N-terminal RING domains, in yeast two-hybrid experiments and pull-down assays; BRC-1/BRD-1 heterodimers may interact with RAD-51 and other proteins via mutual binding to UBC-9; brc-1 is genetically dispensable for the induction of nuclear ATL-1 foci by gamma-irradiation or hydroxyurea. WormBase CDS description: Zinc finger, C3HC4 type (RING finger)
C36B1.10 C36B1.10 P W All gene names: C36B1.10; 1J326; CE05377; WBGene00007977; WP:CE05377 WormBase description: serine/threonine kinase
C36B1.12 C36B1.12 P W All gene names: imp-1; C36B1.12; C36B1.12a.1; C36B1.12a.2; C36B1.12c.1; C36B1.12c.2; 1J331; CE05379; CE38290; CE38291; Q93346_CAEEL; WBGene00007979; WP:CE05379; WP:CE38290; WP:CE38291
C36B7.4 C36B7.4 P W All gene names: C36B7.4; CE25805; WBGene00016467; WP:CE25805; XH704
C36C5.3 C36C5.3 P W All gene names: srbc-6; C36C5.3; 5D641; CE38041; NM_071473; WBGene00016472; WP:CE38041 WormBase description: 7TM chemoreceptor, srbc family
C36F7.1 C36F7.1 P W All gene names: irx-1; C36F7.1; 1K114; CE17526; IRX1_CAEEL; WBGene00007984; WP:CE17526 WormBase description: irx-1 encodes a homeodomain-containing protein that is most similar to members of the Iroquois subclass of TALE (three amino acid loop extension) superclass atypical homeodomain proteins; IRX-1 is predicted to function as a transcriptional regulator during development, but as loss of irx-1 activity via RNAi results in no obvious defects, the precise role of irx-1 in C. elegans development and/or behavior is not yet known. WormBase CDS description: Homeobox domain
C37A2.3 C37A2.3 P W All gene names: C37A2.3; 1H361; CE08612; WBGene00016491; WP:CE08612 WormBase description: acyl-CoA dehydrogenase
C38C10.3 C38C10.3 P W All gene names: C38C10.3; 3K472; CE00106; WBGene00008001; WP:CE00106; YLD3_CAEEL
C38C10.4 C38C10.4 P W All gene names: ags-3.3; gpr-2; C38C10.4; 3K482; CE00107; GPR2_CAEEL; NM_066665; WBGene00001689; WP:CE00107 WormBase description: gpr-2 encodes a protein containing a GPR (G Protein Regulator)/GoLoco motif characteristic of guanine nucleotide exchange factors specific for G-alpha GTPases; GPR-2 appears to function redundantly during early embryogenesis and germ-line development to regulate chromosome and spindle movements during cell division; GPR-2 likely acts as a positive regulator of G protein signaling and specifically, may regulate GOA-1 signaling in the embryo; GPR-2 forms a protein complex with the nearly identical GPR-1 and with LIN-5, a coiled-coil protein that is required for proper localization of GPR-2 to the cell cortex and spindle asters of the early embryo; in addition, proper GPR-2/GPR-1/LIN-5 localization between the P2 and EMS blastomeres at the four-cell stage, which may contribute to spindle positioning in EMS, requires the MES-1/SRC-1 tyrosine kinase signaling pathway; GPR-2 is believed to act downstream of, or in parallel to, PAR-3, a PDZ domain-containing protein, in mitotic spindle positioning in the early embryo.
C38C3.3 C38C3.3 P W All gene names: C38C3.3; 5B975; CE29711; WBGene00016512; WP:CE29711
C38D4.1 C38D4.1 P W All gene names: C38D4.1; 3F874; CE00915; CE17538; WBGene00008003; WP:CE00915; WP:CE17538
C38D4.3 C38D4.3 P W All gene names: C38D4.3; 3F881; CE36378; WBGene00008004; WP:CE36378 WormBase description: mel-28 was identified in a screen for genes involved in cell division in the early embryo; mel-28 mutants have no or poorly visible pronuclei and a weak mititic spindle; the molecular identity of mel-28 is unknown.
C40H1.1 C40H1.1 P W All gene names: cpb-1; C40H1.1; 3K413; CE00109; CPB1_CAEEL; NM_066650; WBGene00000770; WP:CE00109 WormBase description: cpb-1 encodes a cytoplasmic polyadenylation element binding (CPEB) protein homolog involved in two steps of spermatogenesis; two CPEB proteins have distinct functions in spermatogenesis, with FOG-1 specifying sperm cell fate, and CPB-1 conversely executing that decision, being required for progression through meiosis; cpb-1(RNAi) spermatocytes fail to undergo meiotic cell divisions; CPB-1 protein is present in the germ line just prior to overt spermatogenesis, but once sperm differentiation begins, CPB-1 disappears; CPB-1 physically interacts with EBF, which, like CPEB, regulates genes by binding the 3' UTRs of mRNAs; while CPB-1 is required for spermatogenesis, it is dispensable for oogenesis; this is in contrast to CPEBs in vertebrates (Xenopus), arthropods (Drosophila), and molluscs (Spisula), which all participate in oogenesis. WormBase CDS description: Ovarian protein (fly)
C41D11.1 C41D11.1 P W All gene names: C41D11.1; 1F33; CE08658; WBGene00016561; WP:CE08658
M01B2.11 C41G6.2 P W
C41G7.2 C41G7.2 P W All gene names: klp-16; C41G7.2; C41G7.2.1; C41G7.2.2; 1K89; CE08666; NM_060126; WBGene00002226; WP:CE08666 WormBase description: klp-16 encodes a C-terminal motor kinesin orthologous to the Drosophila melanogaster Ncd and Saccharomyces cerevisiae Kar3; however KLP-16 along with KLP-3, KLP-15 and KLP-17 form an unique subgroup based on amino acid sequence and secondary structure analysis; klp-16 is involved in development of the nervous system in embryos and in chromosome segregation; in situ RNA hybridization experiments indicate that klp-16 is localized in the anterior nervous system in the head region of late embryos. WormBase CDS description: kinesin, kinesin-14 family
C41G7.3 C41G7.3 P W All gene names: C41G7.3; 1K94; CE08667; WBGene00008061; WP:CE08667
C42C1.10 C42C1.10 P W All gene names: C42C1.10; C42C1.10.1; C42C1.10.2; 4N47; CE29222; WBGene00016588; WP:CE29222 WormBase description: mitochondrial carrier protein
C42C1.4 C42C1.4 P W All gene names: C42C1.4; 4N36; CE16910; CE36276; WBGene00016582; WP:CE16910; WP:CE36276
C42C1.8 C42C1.8 P W All gene names: C42C1.8; 4N57; CE16914; WBGene00016586; WP:CE16914
C42D4.8 C42D4.8 P W All gene names: rpc-1; rpo-1; C42D4.8; 4H926; CE31330; NM_068726; WBGene00004411; WP:CE31330 WormBase description: DNA-directed RNA polymerase II largest subunit
C43E11.1 C43E11.1 P W All gene names: cogc-5; C43E11.1; C43E11.1.1; C43E11.1.2; 1E841; CE23592; WBGene00016601; WP:CE23592 WormBase description: cogc-5 encodes an ortholog of mammalian COG-5, a subunit of lobe B of the conserved oligomeric Golgi complex (COGC); COGC-5 is also orthologous to Drosophila FOUR WAY STOP (required for fly spermatogenesis); COGC-5 is weakly required for normal gonadal distal tip cell migration, a process that also requires seven other orthologs of COGC subunits; like other lobe B subunits in both C. elegans and S. cerevisiae, COGC-5 is only partially required for normal function, while lobe A subunits are strongly required in either worms or yeast.
C43E11.10 C43E11.10 P W All gene names: cdc-6; C43E11.10; 1E838; CE08688; NM_058942; WBGene00000382; WP:CE08688 WormBase description: cdc-6 encodes a homolog of an origin complex component (CDC6) which in yeast controls the start of DNA replication, and also has a distant paralog (Y39A1A.12) within the C. elegans genome; CDC-6 is superficially dispensable for embryonic viability, perhaps because of redundancy with Y39A1A.12.
C43E11.5 C43E11.5 P W All gene names: C43E11.5; 1E807; CE08683; WBGene00016605; WP:CE08683
C44B7.12 C44B7.10 P W
C44B9.2 C44B9.2 P W All gene names: C44B9.2; 3L965; CE05404; Q18603_CAEEL; WBGene00008079; WP:CE05404
C44B9.3 C44B9.3 P W All gene names: C44B9.3; 3L966; CE05405; WBGene00008080; WP:CE05405
C45B11.1 C45B11.1 P W All gene names: pak-4; tag-66; C45B11.1; 5L518; CE05425; CE20564; WBGene00006443; WP:CE05425; WP:CE20564 WormBase description: P21-Rho-binding domain ; Eukaryotic protein kinase domain
C45G3.1 C45G3.1 P W All gene names: tag-255; C45G3.1; 1J798; CE15710; O17666_CAEEL; WBGene00008107; WP:CE15710 WormBase description: The C45G3.1 gene encodes a protein, with one N-terminal calponin-like actin-binding domain and two IQ calmodulin-binding domains, that is likely to be required for spindle structure and function, and (indirectly) for neural function, based on its orthology to Drosophila ABNORMAL SPINDLE and on its joint sterile and uncoordinated RNAi phenotypes; C45G3.1 is also orthologous to human ASPM (OMIM:605481), which when mutated leads to primary microcephaly; C45G3.1 is required for embryonic and larval viability, germline maintenance, vulval morphogenesis, meiosis, and locomotion. WormBase CDS description: Actinin-type actin-binding domain containing proteins
C45G9.1 C45G9.1 P W All gene names: C45G9.1; 3G165; CE24851; WBGene00016673; WP:CE24851; YQI1_CAEEL WormBase description: Protein kinase
C45G9.8 C45G9.8 P W All gene names: C45G9.8; 3G140; CE01859; WBGene00016679; WP:CE01859; YQI8_CAEEL
C45H4.10 C45H4.10 P W All gene names: srbc-24; C45H4.10; 5C629; CE08743; NM_071181; WBGene00016692; WP:CE08743 WormBase description: 7TM chemoreceptor, srbc family
C45H4.9 C45H4.9 P W All gene names: srbc-23; C45H4.9; 5C631; CE38052; NM_071182; WBGene00016691; WP:CE38052 WormBase description: 7TM chemoreceptor, srbc family
C46A5.1 C46A5.1 P W All gene names: C46A5.1; 4I529; CE08751; WBGene00016698; WP:CE08751 WormBase description: protein-tyrosine phosphatase
C46E10.9 C46E10.9 P W All gene names: C46E10.9; 2E18; CE36111; WBGene00016713; WP:CE36111 WormBase description: zinc finger protein
C46F11.3 C46F11.3 P W All gene names: C46F11.3; 3E738; CE08774; WBGene00008118; WP:CE08774
C46F11.4 C46F11.4 P W All gene names: C46F11.4; C46F11.4.1; C46F11.4.2; 3E748; CE17559; WBGene00008119; WP:CE17559 WormBase description: ATP-dependent RNA helicase
C46H11.6 C46H11.6 P W All gene names: C46H11.6; 1F591; CE08788; WBGene00016730; WP:CE08788
C47B2.2 C47B2.2 P W All gene names: C47B2.2; C47B2.2b.1; C47B2.2b.2; CE17562; CE23599; WBGene00008131; WP:CE17562; WP:CE23599
C47D12.8 C47D12.8 P W All gene names: xpf-1; C47D12.8; VF13D12L.2; 2L995; CE24855; WBGene00008140; WP:CE24855 WormBase description: C47D12.8 encodes an ortholog of the DNA repair protein XPF/ERCC4, which when mutated in humans leads to xeroderma pigmentosum (complementation group F; OMIM:133520); C47D12.8(RNAi) animals are hypersensitive to ultraviolet radiation, with increased germ cell apoptosis and embryonic lethality; C47D12.8 protein interacts with F10G8.7 (an ERCC1 ortholog) in yeast two-hybrid assays; C47D12.8 is expressed broadly in both embryonic and postembryonic animals, and is required for embryonic development; C47D12.8 is upregulated in dauers, and shares an operon with kel-1 and VF13D12L.3. WormBase CDS description: DNA repair protein RAD16 like
C47E12.10 C47E12.10 P W All gene names: C47E12.10; 4K737; CE05454; WBGene00008153; WP:CE05454
C47E8.1 C47E8.1 P W All gene names: C47E8.1; 5P147; CE35837; WBGene00008141; WP:CE35837
C47G2.5 C47G2.5 P W All gene names: C47G2.5; C47G2.5.1; C47G2.5.2; 2L591; CE38162; Q18696_CAEEL; WBGene00008166; WP:CE38162
C48B4.11 C48B4.11 P W All gene names: C48B4.11; 3K656; CE00487; WBGene00008174; WP:CE00487; YLHA_CAEEL
C48B4.9 C48B4.9 P W All gene names: C48B4.9; 3K652; CE00485; WBGene00008172; WP:CE00485; YLH9_CAEEL
C48B6.6 C48B6.6 P W All gene names: mab-1; smg-1; C48B6.6; 1H478; CE30258; CE36919; NM_059569; SMG1_CAEEL; WBGene00004879; WP:CE30258; WP:CE36919 WormBase description: kinase
C48B6.9 C48B6.9 P W All gene names: C48B6.9; 1H502; CE08811; WBGene00016745; WP:CE08811
C48C5.3 C48C5.3 P W All gene names: C48C5.3; CE04226; WBGene00016748; WP:CE04226; XJ576
C49H3.10 C49H3.10 P W All gene names: imb-6; C49H3.10; 4I682; CE29726; NM_068919; WBGene00002080; WP:CE29726 WormBase description: imb-6 encodes an importin-beta-like protein orthologous to vertebrate Exportin-t, a specific mediator of tRNA export from the nucleus; IMB-6 is predicted to function by binding tRNAs directly in the presence of the RAN-1 GTPase and facilitating their nucleocytoplasmic transport; in C. elegans, loss of imb-6 function via RNA-mediated interference (RNAi) does not result in any obvious abnormalities. WormBase CDS description: importin beta, nuclear transport factor
C49H3.6 C49H3.6 P W All gene names: C49H3.6; 4I671; CE29380; CE30506; WBGene00016792; WP:CE29380; WP:CE30506
C50B6.2 C50B6.2 P W All gene names: C50B6.2; C50B6.2.1; C50B6.2.2; 5N792; CE08871; WBGene00008218; WP:CE08871 WormBase description: histone binding protein
C50B6.3 C50B6.3 P W All gene names: C50B6.3; 5N795; CE08872; WBGene00008219; WP:CE08872
C50C3.8 C50C3.8 P W All gene names: bath-42; C50C3.8; C50C3.8.1; C50C3.8.2; 3J252; BAT42_CAEEL; CE00124; WBGene00016803; WP:CE00124 WormBase description: The C50C3.8 gene encodes a protein with a meprin-associated Traf homology (MATH) domain that may be involved in apoptosis.
C50D2.3 C50D2.3 P W All gene names: C50D2.3; 2A397; CE08888; WBGene00016807; WP:CE08888
C50D2.5 C50D2.5 P W All gene names: C50D2.5; 2A389; CE38492; PM14_CAEEL; WBGene00016808; WP:CE38492
C50E3.10 C50E3.10 P W All gene names: C50E3.10; 5I80b; CE08903; WBGene00016821; WP:CE08903
C50E3.12 C50E3.12 P W All gene names: C50E3.12; 5I96; CE08905; WBGene00016823; WP:CE08905
C50F2.2 C50F2.2 P W All gene names: C50F2.2; 1E455; CE27877; WBGene00016836; WP:CE27877
C50F2.3 C50F2.3 P W All gene names: phi-4; C50F2.3; C50F2.3.1; C50F2.3.2; 1E447; CE08909; WBGene00016837; WP:CE08909
C50F4.10 C50F4.10 P W All gene names: C50F4.10; 5K10; CE33984; WBGene00008235; WP:CE33984 WormBase description: serine/threonine kinase
C50F7.3 C50F7.3 P W All gene names: C50F7.3; 4I497; CE04241; WBGene00016843; WP:CE04241
C52D10.8 C52D10.8 P W All gene names: skr-13; C52D10.8; 4S106; CE17592; NM_070641; WBGene00004819; WP:CE17592 WormBase description: The skr-13 gene encodes a homolog of Skp1 in S. cerevisiae that has no known function in vivo, since skr-13(RNAi) animals are at least superficially normal. WormBase CDS description: cyclin A-associated protein
C52D10.9 C52D10.9 P W All gene names: skr-8; C52D10.9; C52D10.9.1; C52D10.9.2; 4S108; CE17593; NM_070643; WBGene00004814; WP:CE17593 WormBase description: skr-8 encodes a homolog of Skp1 in S. cerevisiae, a component of the SCF (Skp1, Cullin, F-box) ubiquitin-ligase complex that regulates ubiquitin-mediated protein degradation; SKR-8 is required for is required for posterior body morphogenesis, embryonic and larval development, and cell proliferation; SKR-8 can interact with CUL-1, a C. elegans cullin homolog. WormBase CDS description: cyclin A-associated protein
C53B4.2 C53B4.2 P W All gene names: C53B4.2; 4J733; CE32836; WBGene00008272; WP:CE32836
C53D6.4 C53D6.4 P W All gene names: C53D6.4; 4J784; CE36284; WBGene00008281; WP:CE36284 WormBase description: angiotensin receptor like
C54G10.2 C54G10.2 P W All gene names: rfc-1; C54G10.2; 5P124; CE20613; NM_074218; WBGene00004337; WP:CE20613 WormBase description: replication factor C 140 KD subunit like
C54G10.3 C54G10.3 P W All gene names: pmp-3; C54G10.3; 5P133; CE05518; NM_074219; WBGene00004060; WP:CE05518 WormBase description: peroxisomal membrane protein (PMP70)
C54G4.3 C54G4.3 P W All gene names: C54G4.3; 1I580; CE05509; WBGene00008313; WP:CE05509
C54G4.9 C54G4.9 P W All gene names: C54G4.9; 1I602; CE05515; WBGene00008318; WP:CE05515
C55B7.11 C55B7.11 P W All gene names: C55B7.11; 1H88; CE09022; WBGene00016947; WP:CE09022
C56C10.7 C56C10.7 P W All gene names: C56C10.7; C56C10.7a.1; C56C10.7a.2; C56C10.7b.1; C56C10.7b.2; 2G876; CE29739; CE29740; Q95QQ3_CAEEL; WBGene00016964; WP:CE29739; WP:CE29740
C56E6.1 C56E6.1 P W All gene names: tag-177; C56E6.1; 2G823; CE04273; WBGene00006522; WBGene00016969; WP:CE04273
C56E6.3 C56E6.3 P W All gene names: C56E6.3; 2G808; CE04275; CE35261; Q18897_CAEEL; WBGene00016971; WP:CE04275; WP:CE35261
D1007.10 D1007.10, D1007.11 P W All gene names: D1007.10; 1F157; CE09045; CE34282; CE36921; WBGene00017007; WP:CE09045; WP:CE34282; WP:CE36921
D1007.10 D1007.10, D1007.11 P W All gene names: D1007.10; 1F157; CE09045; CE34282; CE36921; WBGene00017007; WP:CE09045; WP:CE34282; WP:CE36921
D1007.5 D1007.5 P W All gene names: D1007.5; D1007.5a.1; D1007.5a.2; D1007.5b.1; D1007.5b.2; 1F150; CE29034; CE33577; WBGene00017003; WP:CE29034; WP:CE33577
D1007.7 D1007.7 P W All gene names: D1007.7; 1F166; CE26916; WBGene00017004; WP:CE26916 WormBase description: RNA-binding protein
D1014.2 D1014.2 P W All gene names: SRQ-5; D1014.2; 5I625; CE07004; WBGene00017015; WP:CE07004
D1022.7 D1022.7 P W All gene names: aka-1; kap-1; D1022.7; 2H764; AKAP; CE02581; CE31775; CE31776; NM_063164; WBGene00000101; WP:CE02581; WP:CE31775; WP:CE31776 WormBase description: aka-1 encodes an A kinase anchor protein that has mutiple isoforms, all of which have a zinc-finger domain of the FYVE type; interacts with KIN-2 in vitro.
D1037.5 D1037.5 P W All gene names: D1037.5; 1E258; CE39008; WBGene00017026; WP:CE39008 WormBase description: phospholipase
D1046.1 D1046.1 P W All gene names: D1046.1; D1046.1.1; D1046.1.2; D1046.1.3; D1046.1.4; 4J693; CE03094; Q18937_CAEEL; WBGene00008362; WP:CE03094 WormBase description: glycine-rich RNA-binding protein
D1046.2 D1046.2 P W All gene names: D1046.2; 4J688; CE32844; WBGene00008363; WP:CE32844 WormBase description: Zinc finger, C2H2 type
D1054.15 D1054.15 P W All gene names: phi-13; tag-135; D1054.15; D1054.15.1; D1054.15.2; 5L288; CE05533; WBGene00006481; WP:CE05533 WormBase description: beta transducin like protein
D1081.3 D1081.3 P W All gene names: D1081.3; 1J38; CE05535; WBGene00008381; WP:CE05535
D1081.5 D1081.5 P W All gene names: D1081.5; 1J53; CE05537; WBGene00008383; WP:CE05537 WormBase description: ankyrin motif
D1081.7 D1081.7 P W All gene names: D1081.7; D1081.7.1; D1081.7.2; 1J65; CE05539; WBGene00008385; WP:CE05539
D2005.4 D2005.4 P W All gene names: D2005.4; 1I393; CE17619; Q93410_CAEEL; WBGene00008399; WP:CE17619
D2005.5 D2005.5 P W All gene names: drh-3; ekl-3; D2005.5; 1I401; CE36120; WBGene00008400; WP:CE36120 WormBase description: RNA helicase like
D2013.2 D2013.2 P W All gene names: D2013.2; 2J611; CE00928; WBGene00008402; WP:CE00928; YLN2_CAEEL WormBase description: beta-transducin
D2023.6 D2023.6 P W All gene names: D2023.6; 5M309; CE09076; WBGene00008410; WP:CE09076 WormBase description: D2023.6 is orthologous to a set of uncharacterized putative protein kinases from eukaryotes and from prokaryotes (e.g., UbiB from E. coli), and paralogous to COQ-8 from C. elegans and ABC1 (COQ8) from S. cerevisiae; like COQ-8, D2023.6 may be involved in ubiquinone (coenzyme Q9) biosynthesis. WormBase CDS description: Yeast ABC1 protein like
D2030.6 D2030.6 P W All gene names: D2030.6; D2030.6.1; D2030.6.2; 1I162; CE09083; P90786_CAEEL; WBGene00008416; WP:CE09083
D2030.7 D2030.7 P W All gene names: D2030.7; D2030.7.1; D2030.7.2; 1I165; CE30270; WBGene00008417; WP:CE30270 WormBase description: Zinc finger, C3HC4 type (RING finger)
D2030.8 D2030.8 P W All gene names: D2030.8; 1I169; CE28545; WBGene00008418; WP:CE28545
D2085.2 D2085.2 P W All gene names: D2085.2; 2I949; CE34785; WBGene00008427; WP:CE34785
D2085.4 D2085.4 P W All gene names: D2085.4; 2I957; CE15744; WBGene00008429; WP:CE15744 WormBase description: similarity with a human hypothetical protein (PIR Acc. No. A38919)
D2092.2 D2092.2 P W All gene names: D2092.2; D2092.2.1; D2092.2.2; 1H202; CE09101; WBGene00017064; WP:CE09101
D2092.7 D2092.7 P W All gene names: tsp-19; D2092.7; 1H195; CE25838; NM_059503; WBGene00006645; WP:CE25838 WormBase description: transpanin
D2096.12 D2096.3 P W
F36D4.3 E02C12.1 P W
E02H1.2 E02H1.2 P W All gene names: E02H1.2; 2J878; CE01537; WBGene00008456; WP:CE01537; YQN2_CAEEL WormBase description: GTP binding protein
E02H1.3 E02H1.3 P W All gene names: tag-124; E02H1.3; CE01538; TG124_CAEEL; WBGene00006473; WP:CE01538 WormBase description: Yeast DEG-1 protein homolog
E02H4.6 E02H4.6 P W All gene names: E02H4.6; CE05552; WBGene00008464; WP:CE05552; XO868 WormBase description: serine/threonine kinase
EEED8.5 EEED8.5 P W All gene names: CeHRH-1; mog-5; EEED8.5; 2F695; CE01889; MOG5_CAEEL; NM_062618; WBGene00003393; WP:CE01889 WormBase description: The mog-5 gene encodes a DEAH helicase orthologous to the Drosophila CG8241, the human HRH1, and the S. cerevisiae PRP22 proteins. WormBase CDS description: RNA helicase
F02A9.6 F02A9.6 P W All gene names: emb-33; glp-1; F02A9.6; 3K187; CE00237; GLP1_CAEEL; NM_066613; WBGene00001609; WP:CE00237 WormBase description: glp-1 encodes an N-glycosylated transmembrane protein that, along with LIN-12, comprises one of two C. elegans members of the LIN-12/Notch family of receptors; from the N- to the C-terminus, GLP-1 is characterized by ten extracellular EGF-like repeats, three LIN-12/Notch repeats, a CC-linker, a transmembrane domain, a RAM domain, six intracellular ankyrin repeats, and a PEST sequence; in C. elegans, GLP-1 activity is required for cell fate specification in germline and somatic tissues; in the germline, GLP-1, acting as a receptor for the DSL family ligand LAG-2, is essential for mitotic proliferation of germ cells and maintenance of germline stem cells; in somatic tissues, maternally provided GLP-1, acting as a receptor for the DSL family ligand APX-1, is required for inductive interactions that specify the fates of certain embryonic blastomeres; GLP-1 is also required for some later embryonic cell fate decisions, and in these decisions its activity is functionally redundant with that of LIN-12; GLP-1 expression is regulated temporally and spatially via translational control, as GLP-1 mRNA, present ubiquitously in the germline and embryo, yields detectable protein solely in lateral, interior, and endomembranes of distal, mitotic germ cells, and then predominantly in the AB blastomere and its descendants in the early embryo; proper spatial translation of glp-1 mRNA in the embryo is dependent upon genes such as the par genes, that are required for normal anterior-posterior asymmetry in the early embryo; signaling through GLP-1 controls the activity of the downstream Notch pathway components LAG-3 and LAG-1, the latter being predicted to function as part of a transcriptional feedback mechanism that positively regulates GLP-1 expression; signaling through the DNA-binding protein LAG-1 is believed to involve a direct interaction between LAG-1 and the GLP-1 RAM and ankyrin domains WormBase CDS description: GLP-1 protein
F02E11.1 F02E11.1 P W All gene names: F02E11.1; 2D571; CE36815; WBGene00017179; WP:CE36815 WormBase description: ABC transpoter
F02E8.4 F02E8.4 P W All gene names: F02E8.4; CE07019; WBGene00017177; WP:CE07019; XF75
F02E9.4 F02E9.4 P W All gene names: pqn-28; F02E9.4; 1I999; CE33046; NM_059883; WBGene00004117; WP:CE33046 WormBase description: pqn-28 encodes an ortholog of the SIN3 family of histone deacetylase subunits, which also has a glutamine/asparagine-rich domain, possibly involved in epigenetic regulation; pqn-28 has no obvious phenotype in mass RNAi screens; on the basis of its homology, PQN-28, when activated by promoter-specific transcription factors, is expected to work in conjunction with other histone deacetylase components to induce chromatin silencing; PQN-28 may also silence genes by colocating to them with the O-GlcNAc transferase homolog OGT-1.
F02E9.7 F02E9.7 P W All gene names: F02E9.7; 1I991; CE09190; WBGene00008531; WP:CE09190 WormBase description: acid phosphatase
F02H6.2 F02H6.2 P W All gene names: F02H6.2; 4O961; CE17626; WBGene00008535; WP:CE17626
F07A11.2 F07A11.2 P W All gene names: F07A11.2; F07A11.2b.1; F07A11.2b.2; F07A11.2b.3; 2L884; CE03144; CE27915; WBGene00008546; WP:CE03144; WP:CE27915 WormBase description: glucosamine-fructose-6-phosphate aminotransferase
F07A11.3 F07A11.3 P W All gene names: npp-5; F07A11.3; 2L888; CE03145; NM_064080; WBGene00003791; WP:CE03145
F07D3.3 F07D3.3 P W All gene names: F07D3.3; 5J940; CE05568; WBGene00008556; WP:CE05568
F08B4.5 F08B4.5 P W All gene names: F08B4.5; 4J448; CE29749; DPOE2_CAEEL; WBGene00017237; WP:CE29749
F08F3.2 F08F3.2 P W All gene names: acl-6; F08F3.2; F08F3.2a.1; F08F3.2a.2; 5F913; CE09258; CE35851; PLSB_CAEEL; WBGene00017261; WP:CE09258; WP:CE35851 WormBase description: acl-6 encodes a mitochondrial glycerol-3-phosphate acyltransferase; ACL-6 is predicted to play a role in phospholipid metabolism, but as loss of acl-6 activity via large-scale RNAi experiments results in no obvious defects, the precise role of acl-6 in C. elegans development and/or behavior is not yet known.
F08F3.6 F08F3.6 P W All gene names: F08F3.6; 5F896; CE09261; WBGene00017263; WP:CE09261 WormBase description: This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins.
F09D1.1 F09D1.1 P W All gene names: F09D1.1; 2C865; CE20660; WBGene00017280; WP:CE20660 WormBase description: ubiquitin protease
F09E8.3 F09E8.3 P W All gene names: msh-5; F09E8.3; 4N927; CE26678; MSH5_CAEEL; NM_070130; WBGene00003421; WP:CE26678 WormBase description: msh-5 encodes a germline-specific homolog of the yeast and mammalian DNA mismatch repair protein MSH5 (MutS-family) that is required for crossing over and chiasma formation during Caenorhabditis elegans meiosis; inactivation of both rad-51 and msh-5 induces chromosome fragmentation, not seen with inactivation of either gene alone. WormBase CDS description: Yeast DNA mismatch repair protein MSH5 like
F09F7.3 F09F7.3 P W All gene names: F09F7.3; F09F7.3.1; F09F7.3.2; 3G653; CE30653; WBGene00017300; WP:CE30653
F09G2.8 F09G2.8 P W All gene names: F09G2.8; F09G2.8.1; F09G2.8.2; 5H670; CE09303; PLDL_CAEEL; WBGene00017316; WP:CE09303
F09G2.9 F09G2.9 P W All gene names: F09G2.9; F09G2.9.1; F09G2.9.2; 5H674; CE09304; WBGene00017317; WP:CE09304
F10C2.4 F10C2.4 P W All gene names: F10C2.4; 5M525; CE09308; DPOD_CAEEL; WBGene00008645; WP:CE09308 WormBase description: F10C2.4 encodes a homolog of the DNA polymerase delta complex subunit A that is required in embryos for the normal timing of embryonic cell divisions (much as DIV-1 is) and, also, for normal chromosome segregation (probably because of defective DNA replication). WormBase CDS description: DNA polymerase family B
F10D11.2 F10D11.2 P W All gene names: F10D11.2; 1J12; CE32366; WBGene00008648; WP:CE32366
F10E7.8 F10E7.8 P W All gene names: F10E7.8; 2H392; CE04363; Q19300_CAEEL; WBGene00017349; WP:CE04363
F10E9.2 F10E9.2 P W All gene names: F10E9.2; 3J403; CE24893; WBGene00017354; WP:CE24893; YLU2_CAEEL
F10E9.8 F10E9.8 P W All gene names: dcd-1; sas-4; F10E9.8; 3J404; CE29756; NM_066427; SAS4_CAEEL; WBGene00004726; WP:CE29756 WormBase description: sas-4 encodes a predicted coiled-coil protein and centriole component recruited to the centrosome once per cell cycle at the time of organelle duplication and is required for centriole duplication and spindle assembly, levels dictate centrosome size, and also affects germ cell proliferation and locomotion; colocalizes with gamma-tubulin to centrosomes both in sperm and in the syncitial part of the gonad.
F10F2.8 F10F2.8 P W All gene names: F10F2.8; 3F725; CE00953; WBGene00008660; WP:CE00953 WormBase description: C-lectin binding domain
F10G2.4 F10G2.4 P W All gene names: F10G2.4; 5H805; CE09332; WBGene00017365; WP:CE09332
F10G7.4 F10G7.4 P W All gene names: rad-21.1; coh-2; scc-1; F10G7.4; 2E989; CE02628; NM_062435; Q19325_CAEEL; WBGene00004737; WP:CE02628 WormBase description: scc-1 encodes a member of the Rad21/Rec8-like family of cohesion proteins that affects embryonic viability, fertility, the rate of embryonic cell divisions and the incidence of male progeny; interacts with ATL-1, F56D12.5, and F11E6.1 based on yeast two-hybrid assays, and is expressed in nondividing embryonic and germline nuclei. WormBase CDS description: DNA double-strand break repair
F10G7.8 F10G7.8 P W All gene names: rpn-5; F10G7.8; F10G7.8.1; F10G7.8.2; 2E988; CE02632; NM_062434; WBGene00004461; WP:CE02632
F10G8.7 F10G8.7 P W All gene names: F10G8.7; 1K621; CE30750; WBGene00008665; WP:CE30750 WormBase description: DNA excision repair protein
F11A10.5 F11A10.5 P W All gene names: F11A10.5; 4M859; CE03185; WBGene00008686; WP:CE03185
F11A3.2 F11A3.2 P W All gene names: F11A3.2; 5J997; CE05586; CE38501; WBGene00008670; WP:CE05586; WP:CE38501 WormBase description: guanine nucleotide exchange factor
F11G11.9 F11G11.9 P W All gene names: F11G11.9; 2F152; CE09351; THT1_CAEEL; WBGene00017387; WP:CE09351
F12F6.1 F12F6.1 P W All gene names: F12F6.1; 4M351; CE34803; WBGene00008720; WP:CE34803
F12F6.3 F12F6.3 P W All gene names: rib-1; F12F6.3; F12F6.3.1; F12F6.3.2; 4M347; CE24898; EXT1_CAEEL; NM_069779; WBGene00004360; WP:CE24898 WormBase description: The rib-1 gene encodes an ortholog of human EXT1, which when mutated leads to hereditary multiple exostoses, type I (OMIM:133700). WormBase CDS description: MULTIPLE EXOSTOSES HOMOLOG 1
F12F6.5 F12F6.5 P W All gene names: tag-13; F12F6.5; 4M341; CE20680; Q19370_CAEEL; WBGene00006406; WP:CE20680 WormBase description: chimaerin like
F13A7.9 F13A7.9 P W All gene names: skr-11; F13A7.9; 5Q866; CE15814; NM_074740; WBGene00004817; WP:CE15814 WormBase description: The skr-11 gene encodes a homolog of Skp1 in S. cerevisiae that has no known function in vivo, since skr-11(RNAi) animals are at least superficially normal.
F13D12.5 F13D12.5 P W All gene names: F13D12.5; 2M17; CE02184; WBGene00008740; WP:CE02184
F13E9.1 F13E9.1 P W All gene names: F13E9.1; 4L637; CE33773; WBGene00008750; WP:CE33773 WormBase description: SD22 like protein
F13H8.2 F13H8.2 P W All gene names: F13H8.2; 2G563; CE27127; WBGene00017435; WP:CE27127 WormBase description: beta transducin Trp-Asp domains
F14B4.2 F14B4.2 P W All gene names: F14B4.2; F14B4.2a.1; F14B4.2a.2; 1J848; CE05628; CE36925; Q19440_CAEEL; WBGene00008780; WP:CE05628; WP:CE36925 WormBase description: hexokinase
F14B4.3 F14B4.3 P W All gene names: F14B4.3; 1J858; CE05629; WBGene00008781; WP:CE05629 WormBase description: DNA-directed RNA polymerase I
F14D2.4 F14D2.3 P W
F14D2.13 F14D2.8 P W
F14D7.2 F14D7.2 P W All gene names: F14D7.2; 5O772; CE09380; WBGene00008789; WP:CE09380
F14D7.5 F14D7.5 P W All gene names: F14D7.5; 5O780; CE09383; WBGene00008792; WP:CE09383
F14H3.2 F14H3.2 P W All gene names: F14H3.2; 5Q531; CE15827; WBGene00008821; WP:CE15827; YSWJ_CAEEL WormBase description: Putative membrane protein
F15D4.1 F15D4.1 P W All gene names: btf-1; F15D4.1; 2N505; CE15856; NM_064401; WBGene00000274; WP:CE15856 WormBase description: btf-1 encodes a member of the TBP-associated family (TAF), with weak similarity to human TBP-associated factor 172. WormBase CDS description: helicase
F15D4.6 F15D4.6 P W All gene names: F15D4.6; 2N539; CE36132; WBGene00008863; WP:CE36132
F16D3.2 F16D3.2 P W All gene names: rsd-6; F16D3.2; F16D3.2.1; F16D3.2.2; F16D3.2.3; 1I936; CE32384; NM_059868; WBGene00004684; WP:CE32384
F16D3.4 F16D3.4 P W All gene names: F16D3.4; 1I940; CE09437; WBGene00008887; WP:CE09437 WormBase description: F16D3.4 encodes an ortholog of human TUBULIN-SPECIFIC CHAPERONE D (TBCD; OMIM:604649), also known as tubulin-folding cofactor D; F16D3.4 may be a ligand and effector of the ARL2 ortholog EVL-20.
F16H11.3 F16H11.3 P W All gene names: F16H11.3; CE04398; NM_076394; WBGene00017532; WP:CE04398; XF264
F17A2.13 F17A2.13 P W All gene names: F17A2.13; CE33999; WBGene00008904; WP:CE33999; XM941
F17A9.1 F17A9.1 P W All gene names: F17A9.1; 5G595; CE35278; WBGene00017533; WP:CE35278 WormBase description: F17A9.1 encodes a divergent ONECUT class CUT homeobox protein with a single N-terminal cut domain; F17A9.1 has an atypical tyrosine residue at position 48 of its homeodomain rather than a phenylalanine or tryptophan residue; the cut domain may be a compact DNA-binding domain composed of alpha helices; phylogenetically, F17A9.1 is (somewhat distantly) affiliated with C17H12.9, Drosophila ONECUT, and mammalian HNF6 proteins; F17A9.1 has no obvious function in mass RNAi assays.
F17C11.10 F17C11.10 P W All gene names: F17C11.10; 5L442; CE05657; WBGene00008921; WP:CE05657 WormBase description: sepB domain
F17C11.7 F17C11.7 P W All gene names: F17C11.7; 5L438; CE05654; CE37354; WBGene00008918; WP:CE05654; WP:CE37354
F18A1.1 F18A1.1 P W All gene names: F18A1.1; 2H979; CE04401; WBGene00017545; WP:CE04401
F18A1.3 F18A1.3 P W All gene names: lir-1; F18A1.3; F18A1.3a.1; F18A1.3a.2; CE27973; CE27974; CE32627; CE37001; CE39919; Q9Y051_CAEEL; WBGene00003044; WP:CE27973; WP:CE27974; WP:CE32627; WP:CE37001; WP:CE39919 WormBase description: lir-1 encodes a LIN-26-like zinc-finger protein that shares a unique C2H2 motif together with LIR-2, LIR-3, and LIN-26; lir-1 is part of two distinct operons: it is the downstream gene in an operon with lir-2 and the upstream gene in a second, overlapping operon with lin-26; the precise role of lir-1 in C. elegans development and/or behavior is not yet known as neither loss nor gain of lir-1 function appears to result in clear abnormalities and RNAi experiments targeting lir-1 result in embryonic and larval lethality due to loss of lin-26 expression; lir-1 transcripts appear ubiquitous in early embryos, disappear, and then re-appear in later embryonic hypodermal and support cells; during larval development, a lir-1::lacZ fusion that should reflect expression of all transcripts is seen in nearly all cells with the exception of germ cells and post-L1 intestinal cells.
F18A1.4 F18A1.4 P W All gene names: lir-2; F18A1.4; 2H961; CE27975; CE27976; WBGene00003045; WP:CE27975; WP:CE27976 WormBase description: lir-2 encodes a LIN-26-like zinc-finger protein that shares a unique C2H2 motif together with LIR-1, LIR-3, and LIN-26; lir-2 is the upstream gene in an operon with lir-1 which is, in turn, the upstream gene in a second, overlapping operon with lin-26; as loss of lir-2 function via RNAi results in no obvious abnormalities, the precise role of lir-2 in C. elegans development and/or behavior is not yet known; lir-2 transcripts are ubiquitous in early embryos (2-200-cell stages).
F18A1.5 F18A1.5 P W All gene names: F18A1.5; F18A1.5.1; F18A1.5.2; 2H955; CE04405; RFA1_CAEEL; WBGene00017546; WP:CE04405 WormBase description: F18A1.5 encodes the C. elegans ortholog of the replication protein A (RPA) large subunit; by homology, the F18A1.5 gene product is predicted to function as a DNA binding and oligonucleotide oligosaccharide binding (OB) protein that is required for DNA replication, repair, and recombination; large-scale RNAi screens indicate that the product of F18A1.5 is essential for embryonic development, and that in yeast two-hybrid assays interacts with the product of M04F3.1, the RPA medium subunit; in situ hybridization studies indicate that F18A1.5 transcripts are expressed in germ cells. WormBase CDS description: replication factor A
F18A1.6 F18A1.6 P W All gene names: F18A1.6; F18A1.6b.1; F18A1.6b.2; 2H950; CE04406; CE27977; WBGene00017547; WP:CE04406; WP:CE27977
F18A12.1 F18A12.1 P W All gene names: F18A12.1; 2D713; CE09454; WBGene00017550; WP:CE09454 WormBase description: F18A12.1 encodes a neprilysin; neprilysins are thermolysin-like zinc metallopeptidases, found on the outer surface of animal cells, that negatively regulate small signalling peptides (e.g., enkephalin, tachykinin, insulin, and natriuretic peptides) by cleaving them; F18A12.1 has no clear orthologs in other organisms. WormBase CDS description: peptidase
F18A12.2 F18A12.2 P W All gene names: F18A12.2; 2D703; CE36826; WBGene00017551; WP:CE36826
F18A12.4 F18A12.4 P W All gene names: F18A12.4; 2D697; CE36827; WBGene00017553; WP:CE36827 WormBase description: F18A12.4 encodes a neprilysin; neprilysins are thermolysin-like zinc metallopeptidases, found on the outer surface of animal cells, that negatively regulate small signalling peptides (e.g., enkephalin, tachykinin, insulin, and natriuretic peptides) by cleaving them; F18A12.4 has no clear orthologs in other organisms. WormBase CDS description: peptidase
F18C5.2 F18C5.2 P W All gene names: wrn-1; F18C5.2; 2G849; CE31791; NM_062923; WBGene00006944; WP:CE31791; WRN_CAEEL WormBase description: wrn-1 encodes an ortholog of human WRN, which when mutated leads to Werner syndrome (OMIM:277700), and one of four C. elegans homologs of the RecQ DNA helicase family that includes E. coli RecQ; by homology, WRN-1 is predicted to function as a helicase, DNA-dependent ATPase, and exonuclease that plays a key role in DNA replication, recombination, and repair; in C. elegans, loss of wrn-1 activity, via mutation or large-scale RNA-mediated interference (RNAi) screens, does not result in any obvious abnormalities, as animals are viable and fertile, have normal lifespans, and do not appear to have a high rate of genomic instability.
F18C5.4 F18C5.4 P W All gene names: F18C5.4; 2G854; CE31792; WBGene00017559; WP:CE31792
F18F11.2 F18F11.2 P W All gene names: F18F11.2; 4B100; CE17685; WBGene00017575; WP:CE17685
F19B10.2 F19B10.2 P W All gene names: F19B10.2; 2D967; CE32630; WBGene00017584; WP:CE32630
F19F10.10 F19F10.10 P W All gene names: F19F10.10; 5I58; CE09490; WBGene00017606; WP:CE09490
F19F10.6 F19F10.6 P W All gene names: F19F10.6; 5I38; CE09486; WBGene00017602; WP:CE09486
F20A1.9 F20A1.9 P W All gene names: F20A1.9; 5H530; CE35281; WBGene00017620; WP:CE35281
F20C5.1 F20C5.1 P W All gene names: pme-3; F20C5.1; F20C5.1a.1; F20C5.1a.2; F20C5.1a.3; 4J515; CE32867; CE33775; CE37357; PME3_CAEEL; WBGene00004051; WP:CE32867; WP:CE33775; WP:CE37357 WormBase description: poly(ADP-ribose) glycohydrolases
F20C5.3 F20C5.3 P W All gene names: F20C5.3; 4J516; CE35500; WBGene00008968; WP:CE35500
F20D12.1 F20D12.1 P W All gene names: F20D12.1; 4I725; CE04431; CE39920; WBGene00017641; WP:CE04431; WP:CE39920
F20D12.2 F20D12.2 P W All gene names: F20D12.2; 4I717; CE04432; WBGene00017642; WP:CE04432
F20D12.4 F20D12.4 P W All gene names: czw-1; F20D12.4; F20D12.4.1; F20D12.4.2; F20D12.4.3; 4I708; CE04434; NM_068926; WBGene00017643; WP:CE04434
F20D6.6 F20D6.6 P W All gene names: F20D6.6; 5I641; CE07111; WBGene00017636; WP:CE07111 WormBase description: serine/threoninie protein phophatase
F20H11.4 F20H11.4 P W All gene names: F20H11.4; 3H699; CE20702; WBGene00017647; WP:CE20702 WormBase description: protein-tyrosine phosphatase
F21C3.4 F21C3.4 P W All gene names: rde-2; F21C3.4; 1H858; CE37005; CE38174; NM_059656; Q19672_CAEEL; WBGene00004324; WBGene00009003; WP:CE37005; WP:CE38174 WormBase description: rde-2 encodes a novel protein that is conserved in at least two other Caenorhabditis species; rde-2 is required for the functional silencing of chromosomal loci by transgenes (cosuppression) and promotes the effects of RNAi in a step after the formation of a heritable interfering agent, also affects X-chromosome nondisjunction and transposon activation; functions downstream of rde-1 in the RNAi pathway most effective against germline, but not somatically expressed, genes; RDE-2 is present predominantly in the cytosol, in complexes with MUT-7, a predicted exoribonuclease also required for RNA interference.
F21F3.2 F21F3.2 P W All gene names: F21F3.2; 1F473; CE09532; WBGene00017672; WP:CE09532 WormBase description: ser/thr-protein kinase
F21F3.4 F21F3.4 P W All gene names: F21F3.4; 1F465; CE09534; WBGene00017674; WP:CE09534
F21F8.5 F21F8.5 P W All gene names: F21F8.5; 5I744; CE19404; WBGene00017679; WP:CE19404 WormBase description: protease
F21H12.4 F21H12.4 P W All gene names: ptc-2; F21H12.4; 2G374; CE36831; NM_062817; WBGene00004209; WP:CE36831 WormBase description: ptc-2 encodes an ortholog of Drosophila PATCHED (PTC) and human PTCH (OMIM:601309, mutated in basal cell nevus syndrome), which defines one of seven paralogous families of sterol sensing domain (SSD) proteins; PTC-2 is required for normal fat storage; PTC-2 is also required for normal egg osmotic integrity, locomotion, egg laying, and viability in mass RNAi assays. WormBase CDS description: membrane protein patched (ptc)
F21H12.5 F21H12.5 P W All gene names: fbf-2; F21H12.5; 2G380; CE01916; FBF2_CAEEL; NM_062819; WBGene00001402; WP:CE01916 WormBase description: fbf-2 encodes an RNA-binding protein that is one of 11 C. elegans members of the PUF family (Pumilio and FBF) of translational regulators; FBF-2 is nearly identical to FBF-1 with which it is largely redundant in regulating two aspects of germline development: 1)maintenance of stem cell proliferation, and 2)the hermaphroditic switch between spermatogenesis and oogenesis; in maintaining germline stem cells, the FBF proteins, acting through NOS-3, negatively regulate the activity of gld-1 mRNA, which encodes a translational repressor required for meiotic entry; in regulating the sperm-to-oocyte switch, the FBFs act downstream of GLD-3 to negatively regulate the activity of fem-3 mRNA, which encodes a novel protein required for germline sex determination; consistent with their role in germline development, FBF-1 and FBF-2 are expressed in the germline cytoplasm, becoming enriched in the mitotic region during the L4 larval and adult stages.
F22B5.7 F22B5.7 P W All gene names: zyg-9; F22B5.7; F22B5.8; 2I753; CE20707; NM_063383; O61442_CAEEL; WBGene00006994; WP:CE20707 WormBase description: zyg-9 encodes a predicted microtubule-association protein (MAP) of the XMAP215 family; during early embryonic development, maternal zyg-9 activity is required for microtubule-dependent processes such as meiotic and mitotic spindle organization and pronuclear migration; further, zyg-9 is essential for formation of long astral microtubules; ZYG-9 is required for centrosomal localization of TAC-1, the sole C. elegans TACC family member, with which it interacts, and mutually stabilizes, in vivo; in early embryos, ZYG-9 localizes to the meiotic spindle and spindle poles, as well as to mitotic centrosomes; during metaphase and anaphase ZYG-9 localizes to the central spindle region, and during interphase ZYG-9 is cytoplasmic; proper localization of ZYG-9 to the meiotic spindle is dependent upon wild-type activity of MEI-1, an ATPase essential for meiotic spindle formation, while proper localization of ZYG-9 to centrosomes is dependent, at least in part, upon TAC-1. WormBase CDS description: elongation factor
F22B7.6 F22B7.6 P W All gene names: polk-1; F22B7.6; 3J716; CE00159; NM_066498; POLK_CAEEL; WBGene00017696; WP:CE00159 WormBase description: mucb
F22D3.1 F22D3.1 P W All gene names: ceh-38; F22D3.1; 2H245; CE27137; CE29772; HM38_CAEEL; NM_171016; NM_171852; WBGene00000459; WP:CE27137; WP:CE29772 WormBase description: ceh-38 encodes two proteins, by alternative splicing, that belong to the ONECUT class of homeodomain proteins (which includes mammalian hepatocyte nuclear factor-6); ceh-38 is expressed from embryos to adults, and in many different tissues (e.g., pharynx, gut, hypodermis and many nerve cells), but has no known function in vivo.
F22D3.2 F22D3.2 P W All gene names: F22D3.2; 2H237; CE27138; CE37006; CE37762; WBGene00017699; WP:CE27138; WP:CE37006; WP:CE37762 WormBase description: F22D3.2 encodes an ortholog of human folliculin (OMIM:607273, mutated in Birt-Hogg-Dube syndrome).
F22D6.1 F22D6.1 P W All gene names: kin-14; F22D6.1; 1H652; CE05682; NM_059603; WBGene00002198; WP:CE05682 WormBase description: kin-14 encodes a member of the tyrosine-specific subfamily of kinases that contains an SH2 domain, and has with similarity to the human proto-oncogene tyrosine-protein kinase FER. WormBase CDS description: Src homology domain 2, tyrosine-protein kinase (FES/FPS subfamily)
F22D6.5 F22D6.5 P W All gene names: prp-4; F22D6.5; 1H668; CE05686; NM_059607; WBGene00004186; WP:CE05686 WormBase description: serine/threonine kinase
F22F4.2 F22F4.2 P W All gene names: inx-3; opu-3; F22F4.2; F22F4.2.1; F22F4.2.2; CE33055; INX3_CAEEL; NM_076601; WBGene00002125; WP:CE33055; XG615 WormBase description: unc-7-like protein
F22G12.4 F22G12.4 P W All gene names: F22G12.4; 1N748; CE28920; WBGene00009064; WP:CE28920 WormBase description: Ank repeat (6 domains)
F23B12.7 F23B12.7 P W All gene names: F23B12.7; F23B12.7.1; F23B12.7.2; 5O931; CE09599; WBGene00009084; WP:CE09599; YU0O_CAEEL WormBase description: CCAAT binding factor 1 protein like
F23C8.8 F23C8.8 P W All gene names: F23C8.8; F23C8.D; 1C998; CE20717; WBGene00017737; WP:CE20717 WormBase description: protein kinase
F23F12.6 F23F12.6 P W All gene names: rpt-3; F23F12.6; F23F12.6.1; F23F12.6.2; 3H581; CE01253; NM_066028; PRS6B_CAEEL; WBGene00004503; WP:CE01253 WormBase description: rpt-3 encodes a triple A ATPase subunit of the 26S proteasome's 19S regulatory particle (RP) base subcomplex; RPT-3 is required for embryonic, larval, and germline development and by homology, is predicted to function in unfolding protein substrates and translocating them into the core proteolytic particle (CP) of the proteasome.
F25B3.6 F25B3.6 P W All gene names: F25B3.6; 5K60; CE09619; WBGene00009103; WP:CE09619
F25B5.2 F25B5.2 P W All gene names: F25B5.2; F25B5.2.1; F25B5.2.2; 3H51; CE01919; WBGene00017774; WP:CE01919; YQT2_CAEEL
F25G6.2 F25G6.2 P W All gene names: F25G6.2; 5J61; CE30764; WBGene00017797; WP:CE30764
F25G6.9 F25G6.9 P W All gene names: F25G6.9; 5J46; CE32879; WBGene00017800; WP:CE32879
F25H2.13 F25H2.13 P W All gene names: F25H2.13; 1L153; CE15894; WBGene00009124; WP:CE15894 WormBase description: DEAH-type helicase
F25H5.5 F25H5.5 P W All gene names: F25H5.5; 1J736; CE15901; WBGene00009127; WP:CE15901
F25H5.7 F25H5.7 P W All gene names: F25H5.7; 1J733; CE15903; WBGene00009129; WP:CE15903 WormBase description: Protein-tyrosine phosphatase
F25H8.2 F25H8.2 P W All gene names: F25H8.2; F25H8.2.1; F25H8.2.2; 4K697; CE05728; WBGene00009132; WP:CE05728
F26A1.14 F26A1.14 P W All gene names: F26A1.14; 3F938; CE02682; WBGene00017812; WP:CE02682 WormBase description: 2',3'-cyclic nucleotide 3'-phosphodiesterase
F26A3.3 F26A3.3 P W All gene names: ego-1; ego-6; F26A3.3; 1I228; CE27140; NM_059731; WBGene00001214; WP:CE27140 WormBase description: The ego-1 gene encodes a homolog of RNA-directed RNA polymerase that is essential for germ-line development.
F26B1.2 F26B1.2 P W All gene names: F26B1.2; F26B1.2c.1; F26B1.2c.2; F26B1.2c.3; 1G895; CE09674; CE33057; CE33058; CE33059; CE33060; P91277_CAEEL; WBGene00017816; WP:CE09674; WP:CE33057; WP:CE33058; WP:CE33059; WP:CE33060 WormBase description: RNA-binding protein
F26B1.3 F26B1.3 P W All gene names: ima-2; F26B1.3; F26B1.3.1; F26B1.3.2; 1G893; CE09675; IMA2_CAEEL; NM_059423; WBGene00002073; WP:CE09675 WormBase description: ima-2 encodes one of three C. elegans importin alpha proteins; IMA-2 is predicted to function as an adaptor protein that regulates import of nuclear proteins; during development, ima-2 activity is required for normal germline and embryonic mitoses, specifically for proper chromosome segregration and nuclear reassembly; IMA-2 expression is detected in germ cells, oocytes, and early embryonic cells in a dynamic pattern that depends upon the stage of the cell cycle: in germ cells and early embryonic cells at interphase, IMA-2 is cytoplasmic and nuclear envelope-associated, while in oocytes, IMA-2 is cytoplasmic and intranuclear; during mitoses (prometaphase until telophase), IMA-2 surrounds condensed chromosomes, but does not associate with the mitotic spindle; early somatic expression of maternal IMA-2 is diluted upon cell division, with appreciable expression subsequently seen only in the germ line. WormBase CDS description: importin alpha, nuclear transport factor
T28F3.5 F26D10.2 P W
T28F3.3 F26D10.5 P W
F26E4.1 F26E4.1 P W All gene names: sur-6; F26E4.1; 1K333; CE09685; NM_060190; WBGene00006352; WP:CE09685 WormBase description: protein phosphatase
F26E4.10 F26E4.10 P W All gene names: CE-DROSHA; drsh-1; F26E4.10; 1K358; CE29039; NM_060198; RNC_CAEEL; WBGene00009163; WP:CE29039 WormBase description: drsh-1 encodes a predicted RNase III-type ribonuclease that is orthologous to Drosophila and human Drosha; by homology, DRSH-1 is predicted to function as an endoribonuclease that, in the nucleus, initiates cleavage of primary miRNA transcripts (pri-mRNAs) into pre-miRNAs that are then exported to the cytoplasm for further processing; loss of drsh-1 activity via RNAi results in re-expression of a let-7-silenced reporter in adults, suggesting that DRSH-1 is required for let-7 processing; in addition, DRSH-1 also appears to be required for fertility, as adults lacking drsh-1 activity are sterile; along with PASH-1, a double-stranded RNA binding protein, DRSH-1 may be part of a conserved multiprotein complex that regulates nuclear pri-miRNA splicing.
F26G1.1 F26G1.1 P W All gene names: F26G1.1; 2F85; CE37362; WBGene00017837; WP:CE37362
F26G5.1 F26G5.1 P W All gene names: F26G5.1; 5F455; CE39924; WBGene00017843; WP:CE39924
F26H11.4 F26H11.4 P W All gene names: F26H11.4; 2O697; CE15911; WBGene00009182; WP:CE15911
F26H9.8 F26H9.8 P W All gene names: F26H9.8; 1J903; CE09713; WBGene00009178; WP:CE09713 WormBase description: UDP-glucose:glycoprotein glucosyltransferase like
F27C1.6 F27C1.6 P W All gene names: F27C1.6; F27C1.6.1; F27C1.6.2; 1F990; CE09718; P91280_CAEEL; WBGene00017855; WP:CE09718
F27C8.6 F27C8.6 P W All gene names: F27C8.6; F27C8.6.1; F27C8.6.2; 4K352; CE03271; WBGene00009186; WP:CE03271 WormBase description: esterase
F27E5.3 F27E5.3 P W All gene names: F27E5.3; 2K428; CE01564; WBGene00009193; WP:CE01564 WormBase description: homeobox domain
F28B3.7 F28B3.7 P W All gene names: him-1; smc-1; F28B3.7; F28B3.7a.1; F28B3.7a.2; 1F522; CE29497; CE39925; NM_059085; WBGene00001860; WP:CE29497; WP:CE39925 WormBase description: him-1 encodes a homolog of the conserved eukaryotic protein, SMC1, a member of the SMC (structural maintenance of chromosomes) superfamily that is required for embryonic viability, germline mitosis, chromosome pairing, and the segregation of mitotic chromosomes; HIM-1 can interact with SMC-3 and is required for DPY-28 localization to meiotic chromosomes; associates with the chromatin of transition-zone nuclei.
F28C12.5 F28C12.5 P W All gene names: sra-21; F28C12.5; 1N289; CE09752; NM_060816; SRA21_CAEEL; WBGene00005047; WP:CE09752 WormBase description: 7TM chemoreceptor, sra family
F28C6.3 F28C6.3 P W All gene names: cpf-1; F28C6.3; 2I892; CE03274; NM_063421; WBGene00000773; WP:CE03274 WormBase description: cleavage stimulation factor like
F28F8.5 F28F8.5 P W All gene names: F28F8.5; 5Q54; CE09759; WBGene00009223; WP:CE09759
F28F8.6 F28F8.6 P W All gene names: atx-3; tag-70; F28F8.6; 5Q56; ATX3_CAEEL; CE09760; NM_074472; WBGene00006446; WP:CE09760 WormBase description: tag-70/F28F8.6 encodes an ortholog of human ATAXIN-3 (OMIM:607047, mutated in Machado-Joseph disease). WormBase CDS description: Human Machedo-Joseph disease protein 1 like
F28H7.4 F28H7.4 P W All gene names: F28H7.4; 5L226; CE36142; SELT2_CAEEL; WBGene00009238; WP:CE36142
F29C4.6 F29C4.6 P W All gene names: F29C4.6; F29C4.6.1; F29C4.6.2; 4A872; CE17723; WBGene00017928; WP:CE17723
F29D11.2 F29D11.2 P W All gene names: F29D11.2; 1I212; CE09790; WBGene00009254; WP:CE09790
F29G9.2 F29G9.2 P W All gene names: F29G9.2; F29G9.2b.1; F29G9.2b.2; F29G9.2b.3; CE09796; CE27374; NM_072159; NM_182341; O16370_CAEEL; WBGene00017931; WP:CE09796; WP:CE27374
F29G9.7 F29G9.7 P W All gene names: F29G9.7; 5G514; CE36836; WBGene00017933; WP:CE36836 WormBase description: This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins; its encoded protein also contains a Pfam-B45 motif of presently unknown function.
F30A10.3 F30A10.3 P W All gene names: F30A10.3; F30A10.3.1; F30A10.3.2; 1K70; CE32396; WBGene00009262; WP:CE32396
F30A10.6 F30A10.6 P W All gene names: F30A10.6; 1K67; CE09807; WBGene00009264; WP:CE09807 WormBase description: Yeast recessive suppressor RSD1 like
F30F8.1 F30F8.1 P W All gene names: F30F8.1; 1I410; CE09813; WBGene00009270; WP:CE09813
F31B9.3 F31B9.3 P W All gene names: F31B9.3; CE17729; WBGene00009280; WP:CE17729; XQ541
F31F6.1 F31F6.1 P W All gene names: F31F6.1; CE05773; WBGene00009300; WP:CE05773; XP484 WormBase description: member of worm-specific protein family
F31F6.2 F31F6.2 P W All gene names: F31F6.2; CE05774; WBGene00009301; WP:CE05774; XP486 WormBase description: member of worm-specific protein family
F31F6.3 F31F6.3 P W All gene names: F31F6.3; CE05775; WBGene00009302; WP:CE05775; XP488 WormBase description: member of worm-specific protein family
F32A11.3 F32A11.3 P W All gene names: F32A11.3; 2N442; CE17739; WBGene00009308; WP:CE17739
F32B5.4 F32B5.4 P W All gene names: F32B5.4; 1D261; CE09852; WBGene00017978; WP:CE09852
F32D1.10 F32D1.10 P W All gene names: mcm-7; F32D1.10; F32D1.10.1; F32D1.10.2; 5E827; CE09874; NM_071798; WBGene00003159; WP:CE09874 WormBase description: cell division control protein
F32D1.6 F32D1.6 P W All gene names: F32D1.6; 5E852; CE09870; WBGene00017985; WP:CE09870
F32E10.1 F32E10.1 P W All gene names: F32E10.1; 4I347; CE04474; WBGene00017989; WP:CE04474
F32E10.2 F32E10.2 P W All gene names: F32E10.2; 4I341; CE04475; WBGene00017990; WP:CE04475 WormBase description: chromo domain of heterochromatin protein
F32E10.5 F32E10.5 P W All gene names: F32E10.5; 4I340; CE04478; WBGene00017992; WP:CE04478
Y2C2A.1 F32E10.7 P W
F32H2.1 F32H2.1 P W All gene names: gei-11; F32H2.1; 1J541; CE09876; CE17749; NM_060010; NM_060011; WBGene00001568; WP:CE09876; WP:CE17749 WormBase description: gei-11 encodes a protein that contains Myb DNA-binding domains and is homologous to mammalian SNAPC4, required for RNA polymerase II and III transcription of snRNA genes; GEI-11 is required for ventral enclosure during embryonic development, as well as for normal rates of postembryonic growth; GEI-11 interacts with GEX-3, a homolog of mammalian protein ligands of the small GTPase Rac1 that is also essential for embryonic morphogenesis. WormBase CDS description: Myb DNA-binding proteins (2 domains)
F32H2.3 F32H2.3 P W All gene names: spd-2; F32H2.3; F32H2.3.1; F32H2.3.2; 1J544; CE09878; NM_060013; SPD2_CAEEL; WBGene00004953; WP:CE09878 WormBase description: spd-2 encodes a protein with three predicted coiled-coil domains; SPD-2 activity is essential for centrosome maturation and duplication, and hence for proper mitotic spindle assembly; in regulating the early steps of centrosome maturation, SPD-2 acts together with the coiled-coil protein SPD-5, the Aurora-A kinase AIR-1, and the cytoplasmic dynein DHC-1; in regulating centrosome duplication, SPD-2 likely acts together with the ZYG-1 kinase; in both processes, SPD-2 may function to recruit centrosomal components such as ZYG-9 and microtubule-nucleating gamma-tubulin complexes to the developing centrosome; within centrosomes, SPD-2 localizes to both centrioles and the pericentriolar material; efficient centrosomal localization depends upon AIR-1 and DHC-1, while localization specifically to the pericentriolar material depends upon SPD-5.
F32H2.4 F32H2.4 P W All gene names: F32H2.4; 1J547; CE28927; WBGene00009341; WP:CE28927 WormBase description: WD domain, G-beta repeat (3 domains)
F33A8.4 F33A8.4 P W All gene names: F33A8.4; F33A8.4.1; F33A8.4.2; CE17756; NM_063967; WBGene00009352; WP:CE17756
F33D11.1 F33D11.1 P W All gene names: F33D11.1; 1G427; CE09891; WBGene00018000; WP:CE09891 WormBase description: LIM protein
F33D11.10 F33D11.10 P W All gene names: F33D11.10; F33D11.10.1; F33D11.10.2; 1G444; CE09901; WBGene00018007; WP:CE09901 WormBase description: intiation factor/helicase
F33D11.7 F33D11.7 P W All gene names: F33D11.7; 1G426; CE09897; WBGene00018004; WP:CE09897 WormBase description: protein kinase
F33G12.4 F33G12.4 P W All gene names: F33G12.4; F33G12.4.1; F33G12.4.2; F33G12.4.3; 2F326; CE27150; WBGene00018016; WP:CE27150
F33H2.2 F33H2.2 P W All gene names: F33H2.2; 1P619; CE17765; WBGene00009366; WP:CE17765
F33H2.5 F33H2.5 P W All gene names: F33H2.5; 1P598; CE17767; WBGene00009368; WP:CE17767 WormBase description: DNA polymerase family B (3 domains)
F34D10.2 F34D10.2 P W All gene names: F34D10.2; F34D10.2.1; F34D10.2.2; 3E820; CE01570; WBGene00009372; WP:CE01570
F35C11.5 F35C11.5 P W All gene names: F35C11.5; 2I545; CE03285; WBGene00009404; WP:CE03285 WormBase description: phospholipase A2
F35C8.3 F35C8.3 P W All gene names: jkk-1; sek-2; F35C8.3; CE24941; NM_076512; Q9UAH1_CAEEL; WBGene00002177; WP:CE24941; XF989 WormBase description: jkk-1 encodes a member of the MAP kinase kinase superfamily that affects synaptic vesicle localization and is required in type-D motor neurons for normal locomotion; can function in the Hog1 MAP kinase pathway I in yeast as an activator of JNK and is expressed in most neurons
F35D6.1 F35D6.1 P W All gene names: fem-1; isx-1; F35D6.1; 4G298; CE07175; CE28299; FEM1_CAEEL; NM_068423; NM_068424; WBGene00001411; WP:CE07175; WP:CE28299 WormBase description: The fem-1 gene encodes an ankyrin repeat-containing protein orthologous to human FEM1A and is required for masculinization of germline and somatic tissues; FEM-1 is widely expressed and functions as a second messenger in the sex determination pathway, connecting the membrane protein TRA-2A to the transcription factor TRA-1A which it negatively regulates; FEM-1 may also play a role in apoptosis, as it is a substrate for the CED-3 protease and can induce apoptosis when overexpressed in mammalian cells.
F35E2.9 F35E2.9 P W All gene names: F35E2.9; 1M312; CE38343; WBGene00009416; WP:CE38343
F35F10.2 F35F10.2 P W All gene names: srbc-3; F35F10.2; 5D785; CE38070; NM_071514; WBGene00018053; WP:CE38070 WormBase description: 7TM chemoreceptor, srbc family
F35G12.3 F35G12.3 P W All gene names: sel-5; F35G12.3; 3F662; CE00971; CE00972; WBGene00004762; WP:CE00971; WP:CE00972 WormBase description: sel-5 encodes a serine/threonine kinase most similar to mammalian GAK1 and Saccharomyces cerevisiae Pak1p; SEL-5 is required for LIN-12/Notch-mediated signaling events that instruct cells of equivalent developmental potential to adopt distinct fates; sel-5 encodes two protein kinase isoforms generated from alternatively spliced mRNAs and appears to influence cell fate decisions by acting before or during ligand-dependent release of the LIN-12 intracellular domain. WormBase CDS description: serine/threonine kinase
F35H8.1 F35H8.1 P W All gene names: F35H8.1; 2J840; CE35867; WBGene00009446; WP:CE35867
F36A2.1 F36A2.1 P W All gene names: F36A2.1; F36A2.1a.1; F36A2.1a.2; 1J382; CE39364; CE39365; Q9XVN9_CAEEL; WBGene00009451; WP:CE39364; WP:CE39365
F36A2.11 F36A2.11 P W All gene names: F36A2.11; 1J399; CE34181; WBGene00009458; WP:CE34181
F36A2.2 F36A2.2 P W All gene names: F36A2.2; 1J378; CE09942; WBGene00009452; WP:CE09942 WormBase description: Yeast protein 8248 like
F36A4.4 F36A4.4 P W All gene names: F36A4.4; 4F33; CE07180; WBGene00018083; WP:CE07180
F36A4.7 F36A4.7 P W All gene names: ama-1; F36A4.7; 4F21; CE28300; NM_068122; RPB1_CAEEL; WBGene00000123; WP:CE28300 WormBase description: ama-1 encodes the large subunit of RNA polymerase II required for mRNA transcription; AMA-1 is essential for proper embryonic development, particularly for the early division and migration of the endodermal precursor (E) cells that initiate gastrulation; AMA-1 is expressed ubiquitously in the developing embryo until the 550-cell stage. WormBase CDS description: RNA polymerase II
F36D3.8 F36D3.8 P W All gene names: F36D3.8; 5R9; CE15972; WBGene00009473; WP:CE15972
F36D4.5 F36D4.5 P W All gene names: F36D4.5; F36D4.5b.1; F36D4.5b.2; F36D4.5b.3; F36D4.5b.4; 5J900; CE28391; CE30778; WBGene00018090; WP:CE28391; WP:CE30778
F36G9.13 F36G9.13 P W All gene names: F36G9.13; 5Q461; CE15990; WBGene00009489; WP:CE15990
F36H12.10 F36H12.10 P W All gene names: F36H12.10; 4G18; CE09981; WBGene00018124; WP:CE09981
F36H12.11 F36H12.11 P W All gene names: F36H12.11; 4G20; CE09982; WBGene00018125; WP:CE09982
F36H12.13 F36H12.13 P W All gene names: F36H12.13; 4G26; CE09983; WBGene00018126; WP:CE09983
F36H12.2 F36H12.2 P W All gene names: F36H12.2; 4G41; CE34854; WBGene00018118; WP:CE34854
F36H12.8 F36H12.8 P W All gene names: F36H12.8; 4G23; CE09979; WBGene00018122; WP:CE09979
F36H2.2 F36H2.2 P W All gene names: F36H2.2; 1J822; CE36380; WBGene00009499; WP:CE36380
F37A4.4 F37A4.4 P W All gene names: F37A4.4; 3H807; CE24953; WBGene00018134; WP:CE24953; YPT4_CAEEL
F37A4.8 F37A4.8 P W All gene names: isw-1; F37A4.8; 3H794; CE29792; ISW1_CAEEL; NM_066067; WBGene00002169; WP:CE29792 WormBase description: isw-1 encodes a homolog of the chromatin remodeling ATPase ISW1 that may act downstream of or in parallel to synMuv genes, and upstream of or in parallel to the RTK Ras pathway.
F37A8.1 F37A8.1 P W All gene names: F37A8.1; 3F19; CE00986; WBGene00009501; WP:CE00986
F37A8.2 F37A8.2 P W All gene names: F37A8.2; 3F20; CE20754; WBGene00009502; WP:CE20754
F37C12.13 F37C12.13 P W All gene names: F37C12.13; F37C12.13a.1; F37C12.13a.2; 3I286; CE26424; CE30780; WBGene00018154; WP:CE26424; WP:CE30780
F37E3.1 F37E3.1 P W All gene names: F37E3.1; 1H1; CE29793; WBGene00018156; WP:CE29793 WormBase description: CAP-binding protein
F37E3.3 F37E3.3 P W All gene names: F37E3.3; 1H4; CE09999; WBGene00018158; WP:CE09999
F37H8.4 F37H8.4 P W All gene names: F37H8.4; 2L479; CE35871; WBGene00009513; WP:CE35871
F38A5.6 F38A5.6 P W All gene names: F38A5.6; 4H360; CE10036; WBGene00018163; WP:CE10036
F38A5.8 F38A5.8 P W All gene names: F38A5.8; 4H365; CE10040; WBGene00018165; WP:CE10040
F38B7.5 F38B7.5 P W All gene names: duo-1; usp-1; F38B7.5; 5M37; CE33394; NM_073530; WBGene00001110; WP:CE33394 WormBase description: Ubiquitin carboxyl-terminal hydrolase
F38C2.7 F38C2.7 P W All gene names: F38C2.7; 4R32; CE16006; WBGene00009539; WP:CE16006 WormBase description: Zinc finger C-x8-C-x5-C-x3-H type (and similar). (2 domains)
F38E1.3 F38E1.3 P W All gene names: F38E1.3; 5I857; CE04522; WBGene00018178; WP:CE04522 WormBase description: serine /threonine-protein kinase
F38E1.7 F38E1.7 P W All gene names: mom-2; F38E1.7; 5I837; CE17806; MOM2_CAEEL; NM_072753; WBGene00003395; WP:CE17806 WormBase description: mom-2 encodes a member of the Wnt family of secreted signaling glycoproteins that is required for induction of endodermal (gut) tissue in the 4-cell stage embryo; MOM-2, required in the inducing blastomere (P2) at the 4-cell stage, may be the ligand for MOM-5, a Frizzled homolog, thought to act in the receiving blastomere (EMS); MOM-2 genetically interacts in the same pathway as KIN-19, but parallel to APR-1; MOM-2 also may be a ligand for LIN-18, a Ryk homolog. WormBase CDS description: WNT family protein
F38H4.6 F38H4.6 P W All gene names: F38H4.6; 4M612; CE10068; WBGene00009550; WP:CE10068
F41H10.10 F41H10.10 P W All gene names: htp-1; tag-35; F41H10.10; 4G156; CE31692; NM_068398; WBGene00002032; WP:CE31692
F41H10.6 F41H10.6 P W All gene names: F41H10.6; 4G122; CE20772; CE25887; HDA6_CAEEL; WBGene00018319; WP:CE20772; WP:CE25887
F42A6.3 F42A6.3 P W All gene names: F42A6.3; 4E87; CE17055; WBGene00018325; WP:CE17055
F42A6.5 F42A6.5 P W All gene names: F42A6.5; 4E90; CE17057; WBGene00018327; WP:CE17057
F42A6.6 F42A6.6 P W All gene names: F42A6.6; 4E94; CE34559; WBGene00018328; WP:CE34559
F42A9.2 F42A9.2 P W All gene names: lin-49; F42A9.2; 4J389; CE07224; LIN49_CAEEL; NM_069074; WBGene00003034; WP:CE07224 WormBase description: zinc-finger protein
F42C5.5 F42C5.5 P W All gene names: F42C5.5; 4I56; CE04558; WBGene00018347; WP:CE04558
F42G8.6 F42G8.6 P W All gene names: F42G8.6; 4I895; CE28320; WBGene00018357; WP:CE28320 WormBase description: molybdenum/thiazole biosynthesis cofactor
F42G8.8 F42G8.8 P W All gene names: F42G8.8; 4I883; CE17067; WBGene00018359; WP:CE17067 WormBase description: ser/thr-protein phosphatase
F42H10.7 F42H10.7 P W All gene names: F42H10.7; 3J578; CE00169; CE37109; DGC14_CAEEL; WBGene00018371; WP:CE00169; WP:CE37109
F43C1.2 F43C1.2 P W All gene names: mpk-1; sur-1; F43C1.2; F43C1.2a.1; F43C1.2a.2; 3F308; CE01583; CE24971; SUR1_CAEEL; WBGene00003401; WP:CE01583; WP:CE24971 WormBase description: mpk-1 encodes a mitogen-activated protein (MAP) kinase that acts in the vulval precursor cells to affect LET-60(Ras)-mediated induction of vulval cell fates, and also affects larval viability, morphology of the male spicules, and acts in combination with mek-2 to permit germ cell exit from the pachytene stage of first meiotic prophase; both LIN-1 and LIN-31 act genetically downstream of mpk-1 with respect to vulval induction, and LIN-1 and LIN-31 are substrates for MPK-1 in vitro. WormBase CDS description: serine/threonine kinase (CDC2/CDC28 subfamily)
F43D2.2 F43D2.2 P W All gene names: F43D2.2; 5P112; CE10336; WBGene00009651; WP:CE10336
F43E2.10 F43E2.10 P W All gene names: F43E2.10; WBGene00043322
F43E2.4 F43E2.4 P W All gene names: haf-2; F43E2.4; 2H644; CE07240; NM_063136; WBGene00001812; WP:CE07240 WormBase description: haf-2 encodes a predicted transmembrane protein of the ATP-binding cassette (ABC) transporter superfamily; by homology, HAF-2 is proposed to function in ATP-dependent transport of molecules across plasma and intracellular membranes; however, as loss of HAF-2 function via RNA-mediated interference (RNAi) does not result in any abnormalities, the precise role of HAF-2 in C. elegans development and/or behavior is not yet known. WormBase CDS description: membrane transport protein
F43G6.7 F43G6.7 P W All gene names: F43G6.7; 2M101; CE02225; WBGene00009659; WP:CE02225
F43G9.2 F43G9.2 P W All gene names: F43G9.2; 1J185; CE10356; WBGene00009665; WP:CE10356
F43G9.5 F43G9.5 P W All gene names: F43G9.5; 1J193; CE10362; Q93716_CAEEL; WBGene00009668; WP:CE10362 WormBase description: F43G9.5 encodes a NUDIX hydrolase that is a (perhaps evolutionarily conserved) target of transcriptional activation by DAF-16; loss of F43G9.5 function has no obvious effect on lifespan, dauer formation, or fat storage.
F43H9.3 F43H9.3 P W All gene names: F43H9.3; 5I504; CE07247; WBGene00018399; WP:CE07247
F44A2.1 F44A2.1 P W All gene names: tag-153; F44A2.1; 5J807; CE04568; CE27382; Q95QG2_CAEEL; WBGene00006499; WBGene00018401; WP:CE04568; WP:CE27382
F44B9.6 F44B9.6 P W All gene names: lin-36; F44B9.6; 3J106; CE30992; LIN36_CAEEL; NM_066346; WBGene00003021; WP:CE30992
F44B9.8 F44B9.8 P W All gene names: F44B9.8; 3J118; CE37518; RFC5_CAEEL; WBGene00018409; WP:CE37518 WormBase description: ARPA
F44C4.4 F44C4.4 P W All gene names: iri-1; F44C4.4; F44C4.4b.1; F44C4.4b.2; 5H88; CE38823; CE38824; NM_072280; NM_171475; NM_171476; WBGene00002148; WP:CE38823; WP:CE38824
F44D12.8 F44D12.8 P W All gene names: F44D12.8; 4K789; CE03331; WBGene00009685; WP:CE03331
F44E2.8 F44E2.8 P W All gene names: F44E2.8; 3J938; CE32420; WBGene00018421; WP:CE32420; YL58_CAEEL
F44F4.10 F44F4.10 P W All gene names: F44F4.10; 2L206; CE00997; WBGene00009705; WP:CE00997
F44F4.2 F44F4.2 P W All gene names: F44F4.2; F44F4.2.1; F44F4.2.2; 2L174; CE00998; WBGene00009701; WP:CE00998 WormBase description: Protein-tyrosine phosphatase
F44G4.5 F44G4.5 P W All gene names: F44G4.5; 2J290; CE02232; WBGene00009714; WP:CE02232
F45B8.2 F45B8.2 P W All gene names: rgs-10; tag-215; F45B8.2; CE10430; NM_078081; RGS10_CAEEL; WBGene00004353; WBGene00009719; WP:CE10430; XP581 WormBase description: phosphoprotein RGP4 like
F45C12.15 F45C12.15 P W All gene names: F45C12.15; 2C24; CE10464; WBGene00018446; WP:CE10464
F45C12.7 F45C12.7 P W All gene names: F45C12.7; 2C5; CE10448; WBGene00018438; WP:CE10448
F45E4.10 F45E4.10 P W All gene names: gfi-4; F45E4.10; F45E4.10b.1; F45E4.10b.2; 4I412; CE31701; CE31702; NM_068845; NM_068846; WBGene00001584; WP:CE31701; WP:CE31702 WormBase description: gfi-4 encodes a novel protein that was identified in screens for proteins that interact with GEI-4, a coiled-coil domain protein required for embryonic viability, fertility, and vulval morphogenesis that also interacts with GEX-2, a putative Rac-binding protein, and intermediate filaments; based on its interaction with GEI-4, GFI-4 may be predicted to play a role in intermediate filament rearrangements during germline development or embryonic or vulval morphogenesis; however, as loss of gfi-4 activity via large-scale RNAi screens does not result in any obvious abnormalities, the precise role of GFI-4 in C. elegans development and/or behavior is not yet known.
F45E4.6 F45E4.6 P W All gene names: F45E4.6; 4I394; CE36593; WBGene00018471; WP:CE36593
F45E4.9 F45E4.9 P W All gene names: hmg-5; F45E4.9; 4I410; CE10508; NM_068844; WBGene00001975; WP:CE10508
F46A8.9 F46A8.9 P W All gene names: F46A8.9; 1L845; CE18682; WBGene00009752; WP:CE18682
F46F11.10 F46F11.8 P W
F46F5.2 F46F5.2 P W All gene names: F46F5.2; 2B88; CE20822; WBGene00018494; WP:CE20822 WormBase description: protein kinase
F48C1.2 F48C1.2 P W All gene names: F48C1.2; 1F887; CE34311; WBGene00018595; WP:CE34311 WormBase description: This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins.
F48E8.6 F48E8.6 P W All gene names: F48E8.6; 3G535; CE02758; WBGene00018612; WP:CE02758; YR86_CAEEL
F49E11.1 F49E11.1 P W All gene names: mbk-2; F49E11.1; F49E11.1d.1; F49E11.1d.2; F49E11.1d.3; 4N799; CE05897; CE19878; CE23751; CE39735; CE39938; NM_070091; WBGene00003150; WP:CE05897; WP:CE19878; WP:CE23751; WP:CE39735; WP:CE39938 WormBase description: mbk-2 encodes one of two C. elegans members of the DYRK (dual-specificity Yak1-related kinase) family of proteins that includes S. cerevisiae Yak1 and the Drosophila minibrain and DYRK2 kinases; MBK-2 activity is required maternally for the egg-to-embryo transition that occurs during the earliest stages of embryonic development; specifically, MBK-2 is required for: 1) posterior localization of the germ plasm components PIE-1, POS-1, and PGL-1, and 2) postfertilization degradation of a subset of maternal proteins including the MEI-1 and MEI-2 meiosis-specific katanin subunits, the OMA-1 oocyte maturation factor, and residual PIE-1 that remains anteriorly localized after its normal posterior segregation; genetic analyses suggest that, in regulating the segregation and degradation of maternal proteins, mbk-2 lies downstream of the initial embryonic polarity cues established by the PAR/MEX proteins; MBK-2, whose activity appears to depend upon progression through the meiotic divisions, is expressed uniformly in the cortex of oocytes and newly fertilized zygotes; in later zygotes, just prior to the second meiotic division, MBK-2 becomes localized to discrete cortical foci, and by the first mitosis it is found predominantly on centrosomes and chromosomes; MBK-2 is also associated with P granules in the germline blastomeres P2, P3, and P4.
F49E11.7 F49E11.7 P W All gene names: F49E11.7; 4N817; CE05903; WBGene00009893; WP:CE05903 WormBase description: serine/threonine protein phosphatase
F49E8.2 F49E8.2 P W All gene names: F49E8.2; 4I315; CE28407; WBGene00018636; WP:CE28407
F49E8.7 F49E8.7 P W All gene names: F49E8.7; F49E8.7a.1; F49E8.7a.2; F49E8.7b.1; F49E8.7b.2; CE10798; CE37238; Q20632_CAEEL; WBGene00018638; WP:CE10798; WP:CE37238
F49F1.12 F49F1.12 P W All gene names: F49F1.12; 4E904; CE17095; WBGene00018652; WP:CE17095
F52B5.5 F52B5.5 P W All gene names: F52B5.5; F52B5.5a.1; F52B5.5a.2; F52B5.5b.1; F52B5.5b.2; 1I901; CE29805; CE38369; NM_059861; WBGene00000467; WP:CE29805; WP:CE38369 WormBase description: cep-1 encodes an ortholog of the human tumor suppressor p53 (OMIM:191170, mutated in Li-Fraumeni syndrome) that promotes DNA damage-induced apoptosis and is required for normal meiotic segregation in the germ line, and affects sensitivity to hypoxia-induced lethality and longevity in response to starvation; CEP-1 is expressed ubiquitously in embryos and in the nucleoli of a subset of pharyngeal cells.
F52C6.1 F52C6.1 P W All gene names: bath-22; F52C6.1; 2C219; WBGene00018658
F52C6.10 F52C6.10 P W All gene names: bath-7; F52C6.10; 2C176; CE10820; WBGene00018667; WP:CE10820
F52C6.11 F52C6.11 P W All gene names: bath-2; F52C6.11; 2C178; CE35974; WBGene00018668; WP:CE35974
F52C6.2 F52C6.2 P W All gene names: F52C6.2; F52C6.2.1; F52C6.2.2; F52C6.2.3; F52C6.2.4; 2C217; CE32669; O44821_CAEEL; WBGene00018659; WP:CE32669
F52C6.3 F52C6.3 P W All gene names: phi-32; F52C6.3; 2C181; CE36857; O44820_CAEEL; WBGene00018660; WP:CE36857
F52C6.4 F52C6.4 P W All gene names: math-32; F52C6.4; 2C179; CE17096; WBGene00018661; WP:CE17096
F52C6.9 F52C6.9 P W All gene names: bath-6; F52C6.9; 2C174; WBGene00018666
F52C9.8 F52C9.8 P W All gene names: pqe-1; F52C9.8; F52C9.8d.1; F52C9.8d.2; 3G411; CE30672; CE30673; CE30674; CE30675; CE30802; CE30998; CE39256; NM_065734; NM_065735; NM_065736; NM_171119; NM_171120; NM_171864; PQE1_CAEEL; WBGene00004095; WP:CE30672; WP:CE30673; WP:CE30674; WP:CE30675; WP:CE30802; WP:CE30998; WP:CE39256
F53A3.2 F53A3.2 P W All gene names: polh-1; F53A3.2; 3D36; CE28442; NM_065079; WBGene00018721; WP:CE28442 WormBase description: The F53A3.2 gene encodes an ortholog of the human gene XERODERMA PIGMENTOSUM VARIANT RAD30 (POLH; OMIM:603968), which when mutated leads to xeroderma pigmentosum (OMIM:278750).
F53B6.5 F53B6.5 P W All gene names: F53B6.5; 1J525; CE34486; WBGene00009960; WP:CE34486 WormBase description: initiation factor associated protein
F53F10.5 F53F10.5 P W All gene names: npp-11; F53F10.5; F53F10.5.1; F53F10.5.2; 1E389; CE10988; NM_058831; O01576_CAEEL; WBGene00003797; WP:CE10988
F53F4.11 F53F4.11 P W All gene names: F53F4.11; F53F4.11.1; F53F4.11.2; 5O104; CE20849; WBGene00009993; WP:CE20849
F53F8.3 F53F8.3 P W All gene names: F53F8.3; 5V158; CE17857; WBGene00010000; WP:CE17857 WormBase description: Zinc finger, C3HC4 type (RING finger)
F53G12.6 F53G12.6 P W All gene names: spe-8; F53G12.6; 1A593; CE29331; NM_058279; WBGene00004962; WP:CE29331 WormBase description: protein-tyrosine kinase
F54A3.4 F54A3_30.B P W
F54C8.3 F54C8.3 P W All gene names: apc-4; emb-30; F54C8.3; 3K526; CE32676; EMB30_CAEEL; NM_066673; WBGene00001284; WP:CE32676 WormBase description: emb-30 encodes an anaphase-promoting complex/cyclosome (APC/C) component orthologous to mammalian APC-4 and Schizosaccharomyces pombe Lid1; EMB-30 is required for the metaphase-to-anaphase transition during meiosis and mitosis, for establishing anterior-posterior polarity in the early embryo, and for proper localization of germline granules and the maternally provided PAR-2 and PAR-3 proteins.
F54C9.8 F54C9.8 P W All gene names: puf-5; F54C9.8; 2I867; CE02258; NM_063413; WBGene00004241; WP:CE02258 WormBase description: Pumilio-family RNA binding domains (aka PUM-HD, Pumilio homology domain) (6 domains)
F54D1.1 F54D1.1 P W All gene names: F54D1.1; 4M25; CE05936; WBGene00010046; WP:CE05936
F54D10.5 F54D10.5 P W All gene names: F54D10.5; 2E98; CE19455; WBGene00018806; WP:CE19455
F54D5.14 F54D5.14 P W All gene names: F54D5.14; 2L871; CE18730; WBGene00010056; WP:CE18730
F54D5.5 F54D5.5 P W All gene names: F54D5.5; F54D5.5a.1; F54D5.5a.2; 2L856; CE36386; CE37920; WBGene00010051; WP:CE36386; WP:CE37920
F54E7.3 F54E7.4 P W
F54F2.5 F54F2.5 P W All gene names: ztf-1; F54F2.5; 3J878; CE25004; CE32435; WBGene00018833; WP:CE25004; WP:CE32435; ZTF1_CAEEL
F54F7.6 F54F7.6 P W All gene names: F54F7.6; CE03421; WBGene00010066; WP:CE03421; XM483
F54H12.5 F54H12.5 P W All gene names: F54H12.5; 3J54; CE00547; WBGene00018845; WP:CE00547; YMD5_CAEEL WormBase description: This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins.
F55A11.4 F55A11.4 P W All gene names: F55A11.4; 5M253; CMC2_CAEEL; WBGene00010077
F55A11.7 F55A11.7 P W All gene names: F55A11.7; 5M266; CE20873; WBGene00010080; WP:CE20873
F55A12.1 F55A12.1 P W All gene names: F55A12.1; 1F939; CE11117; WBGene00018862; WP:CE11117
F55C5.4 F55C5.4 P W All gene names: F55C5.4; 5M755; CE11156; WBGene00010093; WP:CE11156
F55C5.7 F55C5.7 P W All gene names: F55C5.7; 5M764; CE31961; WBGene00010096; WP:CE31961 WormBase description: serine/threonine kinase
F55F8.7 F55F8.7 P W All gene names: F55F8.7; 1G228; CE11200; WBGene00018895; WP:CE11200 WormBase description: protein-tyrosine phosphatase
F55H2.4 F55H2.4 P W All gene names: lrg-1; F55H2.4; 3K595; NM_066691; WBGene00003067
F56A3.3 F56A3.3 P W All gene names: npp-6; F56A3.3; F56A3.3a.1; F56A3.3a.2; 1F749; CE11218; CE30281; NM_170857; NM_170858; WBGene00003792; WP:CE11218; WP:CE30281 WormBase description: npp-6 encodes a protein with weak similarity to mouse nuclear pore complex protein Nup160, and affects embryonic and larval viability.
F56C9.6 F56C9.6 P W All gene names: F56C9.6; 3I398; CE01325; WBGene00018950; WP:CE01325
F56D1.7 F56D1.5 P W
F56D6.5 F56D6.5 P W All gene names: srz-20; F56D6.5; 4E681; CE37382; NM_068034; WBGene00018973; WP:CE37382 WormBase description: 7TM chemoreceptor, srz family
F56E10.1 F56E10.1 P W All gene names: F56E10.1; 5A583; CE19901; WBGene00018975; WP:CE19901
F56F4.7 F56F4.7 P W All gene names: F56F4.7; 1G720; CE11272; WBGene00018983; WP:CE11272
F56G4.6 F56G4.6 P W All gene names: F56G4.6; 1L956; CE34323; WBGene00010161; WP:CE34323
F56H1.3 F56H1.3 P W All gene names: F56H1.3; 1G306; CE17914; WBGene00018994; WP:CE17914
F56H1.5 F56H1.5 P W All gene names: F56H1.5; 1G338; CE17916; WBGene00018995; WP:CE17916
F56H11.3 F56H11.3 P W All gene names: elo-7; F56H11.3; 4K293; CE35559; NM_069290; WBGene00001245; WP:CE35559 WormBase description: The elo-7 gene encodes a paralog of elo-1 and elo-2, each of which encodes a polyunsaturated fatty acid (PUFA) elongase; ELO-7 has no known function in vivo. WormBase CDS description: Yeast GNS1 like
F56H6.6 F56H6.6 P W All gene names: F56H6.6; 1M876; CE16134; WBGene00010167; WP:CE16134
F57B1.2 F57B1.2 P W All gene names: mtf-1; sun-1; F57B1.2; F57B1.2.1; F57B1.2.2; 5N672; CE11288; NM_073880; SUN1_CAEEL; WBGene00006311; WP:CE11288 WormBase description: sun-1 encodes a paralog of UNC-84, also called matefin, whose general domain organization (one or more central transmembrane and coiled-coil domains, followed by a C-terminal SUN domain) is shared by Sad1p from Schizosaccharomyces pombe and UNC-84 from C. elegans; SUN-1 is a nuclear envelope receptor for CED-4 during apoptosis, and is bound by CED-4 in vitro; SUN-1 is partially required for apoptosis, since sun-1(RNAi) animals have a moderate defect in normal cell death; SUN-1 is strongly expressed in the nuclear envelope of all early embryonic cells, the primordial germ cells Z2 and Z3, and the germ cell lineage (but not in sperm); early (embryonic) SUN-1 protein is provided maternally, while germ line SUN-1 is zygotic; SUN-1 colocalizes with the nuclear lamin LMN-1 in vivo and binds it in vitro; SUN-1 is required for localization of the hook protein ZYG-12 to the nuclear envelope, and thus for the attachment of centrosomes to nuclei; SUN-1 and UNC-84 may define a class of proteins localized to the outer nuclear envelope but not the endoplasmic reticulum.
F57B10.4 F57B10.4 P W All gene names: F57B10.4; 1H143; CE11304; O44741_CAEEL; WBGene00019002; WP:CE11304
F57B10.9 F57B10.9 P W All gene names: F57B10.9; 1H128; CE30546; WBGene00019006; WP:CE30546 WormBase description: F57B10.9 is orthologous to the human gene SPARTIN (TAHCCP1; OMIM:607111), which when mutated leads to disease.
F57B9.7 F57B9.7 P W All gene names: F57B9.7; 3I14; CE31011; CE31012; Q8MQ17_CAEEL; WBGene00018998; WP:CE31011; WP:CE31012
F57B9.8 F57B9.8 P W All gene names: F57B9.8; 3I24; CE29411; WBGene00018999; WP:CE29411 WormBase description: putative protein tyrosine kinase
F57C2.2 F57C2.2 P W All gene names: F57C2.2; 2O804; CE16153; WBGene00010194; WP:CE16153 WormBase description: BTB (also known as BR-C/Ttk) domain.
F57C9.5 F57C9.5 P W All gene names: htp-3; F57C9.5; 1F397; CE11330; NM_059057; WBGene00002034; WP:CE11330
F57C9.7 F57C9.7 P W All gene names: F57C9.7; 1F394; CE11334; WBGene00019013; WP:CE11334
F57G4.2 F57G4.2 P W All gene names: F57G4.2; 5S112; CE18767; WBGene00010207; WP:CE18767
F57G4.8 F57G4.8 P W All gene names: F57G4.8; 5S128; CE18773; WBGene00010212; WP:CE18773 WormBase description: This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins; this gene's encoded protein also contains an FTH/DUF38 motif, which may also mediate protein-protein interaction.
F57H12.5 F57H12.5 P W All gene names: F57H12.5; 4I733; CE17126; WBGene00019020; WP:CE17126 WormBase description: phosphatase
F58A4.3 F58A4.3 P W All gene names: hcp-3; F58A4.3; 3K704; CE00219; HCP3_CAEEL; NM_066727; WBGene00001831; WP:CE00219 WormBase description: The hcp-3 gene encodes a centromere protein (CENP)-A homolog required for kinetochore function; inactivation of hcp-3 in one-cell embryos by RNAi causes a complete loss of kinetochores, with total failure of chromosomes to segregate properly during mitosis, to recruit components to the kinetochore other than HCP-3, or to assemble a stable mitotic spindle; in addition, HCP-4 fails to localize properly to the kinetochore in hcp-3(RNAi) embryos. WormBase CDS description: Histone H3 similarity
F58A4.4 F58A4.4 P W All gene names: pri-1; F58A4.4; 3K702; CE00220; NM_066725; PRI1_CAEEL; WBGene00004180; WP:CE00220 WormBase description: pri-1 encodes a homolog of the DNA polymerase alpha-primase subunit D that is required in embryos for the normal timing of embryonic cell divisions, much as DIV-1 is. WormBase CDS description: DNA primase 49Kd subunit
F58A4.8 F58A4.8 P W All gene names: sas-3; tbg-1; F58A4.8; F58A4.8.1; F58A4.8.2; 3K716; CE00224; NM_066730; TBG_CAEEL; TUBG; WBGene00006540; WP:CE00224 WormBase description: tbg-1 encodes gamma-tubulin; in C. elegans, tbg-1 activity is essential and is required for normal bipolar spindle assembly and function, as well as the fast phase of female pronuclear migration following fertilization; while tbg-1 is required for proper organization and function of kinetochore and interpolar microtubules, it does not appear to be absolutely required for microtubule nucleation and growth; TBG-1 localizes to centrosomes in both interphase and mitotic cells, exhibiting a dynamic behavior during mitosis that differs between anterior and posterior centrosomes. WormBase CDS description: Gamma-like tubulin
F58A6.5 F58A6.5 P W All gene names: F58A6.5; 2F438; CE04678; WBGene00019024; WP:CE04678
F58B3.6 F58B3.6 P W All gene names: F58B3.6; F58B3.6.1; F58B3.6.2; F58B3.6.3; 4M401; CE06008; WBGene00010232; WP:CE06008 WormBase description: interferon-related protein PC4 like
F58B3.8 F58B3.8 P W All gene names: dsl-5; F58B3.8; 4M380; CE06010; NM_069790; WBGene00001107; WP:CE06010 WormBase description: dsl-5 encodes a putative secreted protein with single DSL and EGF domains in series, somewhat like Delta/LAG-2; DSL-5 belongs to a nematode-specific family of Delta/LAG-2-like proteins that includes DSL-1, -2, -3, -5, -6, and -7. WormBase CDS description: EGF-like domain
F58D2.2 F58D2.2 P W All gene names: F58D2.2; 4N955; CE11364; WBGene00010241; WP:CE11364
F58F12.3 F58F12.3 P W All gene names: F58F12.3; 2G676; CE01978; WBGene00019063; WP:CE01978; YRB3_CAEEL
F58G1.3 F58G1.3 P W All gene names: F58G1.3; 2N218; CE35562; O62272_CAEEL; WBGene00010265; WP:CE35562 WormBase description: Protein phosphatase-1 (PP1) (2 domains)
F58G11.3 F58G11.3 P W All gene names: F58G11.3; 5O150; CE11404; WBGene00010281; WP:CE11404
F58G11.6 F58G11.6 P W All gene names: F58G11.6; 5O161; CE11410; WBGene00010283; WP:CE11410
F59A2.1 F59A2.1 P W All gene names: npp-9; F59A2.1; F59A2.1b.1; F59A2.1b.2; F59A2.1b.3; 3E490; CE17939; CE33525; NM_065302; NM_181972; Q86G90_CAEEL; RANUP96; WBGene00003795; WP:CE17939; WP:CE33525 WormBase description: Nucleoporin
F59A3.8 F59A3.8 P W All gene names: F59A3.8; 1G88; CE30549; WBGene00019081; WP:CE30549 WormBase description: protein kinase
F59A6.5 F59A6.5 P W All gene names: F59A6.5; 2F293; CE02790; WBGene00019087; WP:CE02790
F59E10.1 F59E10.1 P W All gene names: orc-2; F59E10.1; 2L167; CE11492; NM_063938; ORC2_CAEEL; WBGene00003882; WP:CE11492; ceOrc2 WormBase description: origin recognition complex, second largest subunit ORC2
F59E10.2 F59E10.2 P W All gene names: cyn-4; cyp-4; mog-6; F59E10.2; 2L162; CE01596; CYP4_CAEEL; NM_063936; WBGene00000880; WP:CE01596 WormBase description: cyp-4 encodes a peptidyl-propyl cis-trans isomerase of the cyclophilin family that is required for sexual differentiation of germ cells in hermaphrodites and affects body-wall muscle cell development; expression is most abundant in early larval stages and is observed exclusively in body- wall striated muscle cells. WormBase CDS description: cyclophilin
F59E12.1 F59E12.1 P W All gene names: F59E12.1; 2F947; CE28569; WBGene00019118; WP:CE28569
F59E12.13 F59E12.13 P W All gene names: fut-3; tag-8; F59E12.13; F59E12.13.1; F59E12.13.2; 2F948; CE29413; NM_062705; O01906_CAEEL; WBGene00006402; WP:CE29413
F59G1.3 F59G1.3 P W All gene names: vps-35; F59G1.3; 2G201; CE39945; NM_062779; WBGene00006933; WP:CE39945 WormBase description: S. cerevisiae vacuolar sorting protein
F59H5.1 F59H5.1 P W All gene names: F59H5.1; 2C803; CE31963; WBGene00019130; WP:CE31963 WormBase description: F59H5.1 encodes an unfamiliar protein with a low-complexity N-terminal region and a C-terminal DUF545 motif (of unknown function, found solely in nematode proteins); F59H5.1 is expressed in neuronal head ganglia, intestinal cells, hypodermal cells, and coelomocytes, with strong expression in embryos; F59H5.1 has no obvious function or phenotype in RNAi assays, whether in a normal background or in goa-1(-) or goa-1(gf) mutant backgrounds.
F59H6.10 F59H6.10 P W All gene names: bath-3; F59H6.10; F59H6.D; 2C316; CE39104; WBGene00019140; WP:CE39104
F59H6.11 F59H6.11 P W All gene names: bath-5; F59H6.11; F59H6.C; 2C318; CE20917; WBGene00019141; WP:CE20917
H01M10.2 H01M10.2 P W All gene names: H01M10.2; CE35729; WBGene00019144; WP:CE35729; XD200
H02I12.5 H02I12.5 P W All gene names: H02I12.5; 4M166; CE16162; O45603_CAEEL; WBGene00010353; WP:CE16162
H02I12.8 H02I12.8 P W All gene names: cyp-31A2; H02I12.8; 4M169; CE37719; NM_069751; WBGene00010354; WP:CE37719 WormBase description: Cytochrome P450
H04D03.2 H04D03.2 P W All gene names: H04D03.2; 3L530; CE16166; CE23792; WBGene00010363; WP:CE16166; WP:CE23792
H04J21.1 H04J21.1 P W All gene names: H04J21.1; 3D456; CE20919; WBGene00019150; WP:CE20919
H05L14.1 H05L14.1 P W All gene names: H05L14.1; 1I550; CE16168; WBGene00010366; WP:CE16168 WormBase description: casein kinase
H06H21.6 H06H21.7 P W
H06H21.9 H06H21.9 P W All gene names: H06H21.9; 4F590; CE17967; WBGene00019165; WP:CE17967
H09I01.A H09I01.A P W
H12C20.2 H12C20.2 P W All gene names: pms-2; H12C20.2; 5M48; CE18807; CE19915; NM_073532; NM_073533; Q9TVL8_CAEEL; WBGene00004064; WP:CE18807; WP:CE19915 WormBase description: DNA mismatch repair protein (PMS2)
H12D21.2 H12D21.2 P W All gene names: H12D21.2; 5P368; CE36698; WBGene00010378; WP:CE36698
H14E04.5 H14E04.5 P W All gene names: cic-1; H14E04.5; H14E04.A; 3D484; CE34571; NM_065147; WBGene00000506; WP:CE34571 WormBase description: cyclin
H17B01.4 H17B01.4 P W All gene names: H17B01.4; H17B01.4b.1; H17B01.4b.2; 2B780; CE27186; CE33410; WBGene00019209; WP:CE27186; WP:CE33410
H19N07.1 H19N07.1 P W All gene names: phi-19; H19N07.1; H19N07.1.1; H19N07.1.2; 5L592; CE32460; O45622_CAEEL; WBGene00010405; WP:CE32460 WormBase description: elongation factor
H26D21.2 H26D21.2 P W All gene names: msh-2; H26D21.2; 1E264; CE21000; NM_058801; WBGene00003418; WP:CE21000 WormBase description: The msh-2 gene encodes a DNA mismatch repair protein homolog that is orthologous to human MSH2 (OMIM:120435); mutation of the human MSH2 gene leads to hereditary non-polyposis colon cancer (OMIM:120436). WormBase CDS description: DNA mismatch repair protein
H38K22.1 H38K22.1 P W All gene names: evl-14; H38K22.1; 3F394; CE33526; NM_065464; WBGene00001352; WP:CE33526 WormBase description: evl-14 encodes a homolog of the yeast sister cohesion protein Pds5p that functions during both mitosis and meiosis and is implicated in the maintenance of sister chromatid cohesion in late prophase, and affects vulval morphology, meiotic germline development, embryonic and larval viability, fertility, and cell divisions in the germ line as well as in vulval and somatic gonad lineages; some of the defects, such as somatic gonad defects, are due at least partially to cell division defects.
JC8.6 JC8.6 P W All gene names: JC8.6; 4O7; CE17989; CE17990; WBGene00010438; WP:CE17989; WP:CE17990
K01A11.4 K01A11.4 P W All gene names: spe-41; trp-3; K01A11.4; K01A11.4.1; K01A11.4.2; 3E530; CE03452; NM_065308; WBGene00004976; WP:CE03452; strpc3 WormBase description: spe-41 encodes one of three C. elegans calcium-permeable cation channels that are members of the TRPC (transient receptor potential canonical) subfamily of TRP channels; spe-41 activity is required in sperm for productive sperm-oocyte interactions during fertilization, after the point of gamete contact; SPE-41 is expressed solely in sperm and upon sperm activation, translocalizes from the membranous organelles of spermatids to the plasma membranes of the cell body and pseudopod of mature sperm, consistent with the observation that the activity of store-operated calcium channels in C. elegans is much higher in mature sperm than in spermatids; when expressed in mammalian tissue culture cells, SPE-41 activity is sufficient to enhance calcium influx. WormBase CDS description: calmodulin-binding trp1 like protein
K01C8.5 K01C8.5 P W All gene names: gei-14; K01C8.5; 2I564; CE35891; NM_063344; Q21088_CAEEL; WBGene00001571; WP:CE35891 WormBase description: gei-14 encodes a novel protein that interacts with GEX-3 in yeast two-hybrid assays.
K01C8.8 K01C8.8 P W All gene names: K01C8.8; 2I573; CE02269; WBGene00010460; WP:CE02269
K01H12.4 K01H12.4 P W All gene names: K01H12.4; 4K479; CE03456; WBGene00010486; WP:CE03456
K02B12.5 K02B12.5 P W All gene names: K02B12.5; 1J94; CE39383; WBGene00010498; WP:CE39383 WormBase description: ankyrin motif
K02B12.8 K02B12.8 P W All gene names: zhp-3; K02B12.8; 1J106; CE34201; NM_059910; WBGene00006976; WP:CE34201 WormBase description: zhp-3 encodes a RING finger protein that is related to the Saccharomyces cerevisiae meiotically expressed protein Zip3p; in C. elegans, ZHP-3 activity is required during meiosis for crossover recombination and chiasma formation; ZHP-3 activity is thus essential for proper chromosome segregation and normal levels of fertility; a ZHP-3::GFP fusion protein localizes along synapsed chromosomes in a manner that is dependent upon the presence of mature synaptonemal complexes.
K02B2.4 K02B2.4 P W All gene names: inx-7; opu-7; K02B2.4; 4G708; CE04690; INX7_CAEEL; NM_068493; WBGene00002129; WP:CE04690
K02B9.1 K02B9.1 P W All gene names: K02B9.1; CE16206; WBGene00010492; WP:CE16206; XO546 WormBase description: isocitrate lyase like
K02C4.3 K02C4.3 P W All gene names: K02C4.3; 2I372; CE01599; UBPY_CAEEL; WBGene00010502; WP:CE01599 WormBase description: ubiquitin carboxyl-terminal hydrolase
K02F2.1 K02F2.1 P W All gene names: dpf-3; K02F2.1; 1H419; CE17153; CE28837; NM_059555; NM_059556; WBGene00001056; WP:CE17153; WP:CE28837 WormBase description: peptidase
K02F2.3 K02F2.3 P W All gene names: phi-6; tag-203; K02F2.3; 1H409; CE17155; WBGene00019323; WP:CE17155
K02F2.4 K02F2.4 P W All gene names: ulp-5; K02F2.4; 1H387; CE17156; NM_059551; WBGene00006740; WP:CE17156
K03H1.1 K03H1.1 P W All gene names: gln-2; K03H1.1; 3L32; CE00507; GLNA_CAEEL; NM_066807; WBGene00001603; WP:CE00507 WormBase description: Glutamine synthetase
K03H1.8 K03H1.8 P W All gene names: K03H1.8; 3L35; CE00572; WBGene00010543; WP:CE00572 WormBase description: Protein tyrosine phosphatase
K04C2.4 K04C2.4 P W All gene names: brd-1; K04C2.4; 3H976; CE32690; NM_066097; WBGene00000265; WP:CE32690 WormBase description: brd-1 encodes an ortholog of the BRCA1-associating protein BARD1 (OMIM:601593), associated with susceptibility to breast cancer; BRD-1 forms a heterodimer with BRC-1, which constitutes an E3 ubiquitin ligase; after irradiation, the DNA checkpoint proteins ATL-1 and MRE-11 are required for BRC-1/BRD-1 heterodimers to associate with the E2 ubiqutin-conjugating enzyme LET-70/Ubc5 and with RAD-51, and to ubiquitylate damaged chromatin; BRD-1 and BRC-1 bind one another, probably through their N-terminal RING domains, in yeast two-hybrid experiments and pull-down assays; BRC-1/BRD-1 heterodimers may interact with RAD-51 and other proteins via mutual binding to UBC-9; brd-1(RNAi) animals have excess chromosomal nondisjunction, abnormally high levels of CEP-1-dependent germ cell apoptosis (both with and without gamma-irradiation) and hypersensitivity to gamma-irradiation (e.g., abnormal sterility after irradiation); BRD-1 autoubiquitylation probably activates the BRC-1/BRD-1 heterodimer; BRD-1 binds SMT-3 (a Sumo homolog) and TAC-1; brd-1 is genetically dispensable for the induction of nuclear ATL-1 foci by gamma-irradiation or hydroxyurea.
K04D7.5 K04D7.5 P W All gene names: gon-4; K04D7.5; 4K967; CE35579; NM_069463; WBGene00001653; WP:CE35579 WormBase description: gon-4 encodes a large (1336-residue), unfamiliar, acidic (20% acidic residues and pI of 4.4), nuclear protein directly required for gonadogenesis in both sexes and, indirectly, for proper germ line and vulval development; gon-4 is expressed (and functionally required) in somatic gonadal cells during early gonadal development; while Z1 and Z4 (the somatic gonad precursor cells) appear to be specified correctly in gon-4 mutant L1 larvae, and other postembryonic events in somatic gonadal development appear to still occur at normal times, the postembryonic cell divisions of Z1 and Z4 are greatly delayed or missing in gon-4 larvae; GON-4 is subtly similar to human HCCA2 (OMIM:607860, expression associated with hepatocellular carcinoma).
K04G2.10 K04G2.10 P W All gene names: K04G2.10; 1I637; CE06104; Q21229_CAEEL; WBGene00010568; WP:CE06104
K04G2.3 K04G2.3 P W All gene names: K04G2.3; 1I610; CE06097; WBGene00010562; WP:CE06097 WormBase description: AAA ATPase
K04G2.8 K04G2.8 P W All gene names: apr-1; K04G2.8; K04G2.8b.1; K04G2.8b.2; 1I631; CE06102; CE18016; NM_059816; WBGene00000156; WP:CE06102; WP:CE18016 WormBase description: The apr-1 gene encodes an ortholog of human APC (OMIM:175100, mutated in familial adenomatous polyposis) that is required for germline fertility, the control of homeodomain expression (CEH-13 and LIN-39) during embryogenesis and vulval development, and for the migration and elongation of hypodermal cells during embryo morphogenesis; APR-1 is thought to reside in adherens junctions, while also stimulating two beta-catenins in Wnt signalling (HMP-2 in migrating epithelial cells, and BAR-1 in the vulval precursor cells); however, APR-1 also binds PRY-1/axin, and with PRY-1 inhibits RAS-independent Wnt induction of LIN-39.
K05C4.4 K05C4.4 P W All gene names: K05C4.4; 1P325; CE19972; WBGene00010581; WP:CE19972
K05C4.6 K05C4.6 P W All gene names: hmp-2; K05C4.6; KO5C4.6; 1P333; CE19974; HMP2_CAEEL; NM_061165; WBGene00001979; WP:CE19974 WormBase description: hmp-2 encodes a beta-catenin; HMP-2 activity is required during embryonic development for cell adhesion at adherens junctions, cell migration, and body morphogenesis; as a beta-catenin, HMP-2 likely functions solely as part of a cadherin-catenin complex, as in yeast two-hybrid assays, HMP-2 is the only C. elegans beta-catenin that binds HMP-1/alpha-catenin and HMR-1/cadherin; additionally, in the embryo, HMP-2 co-localizes to sites of epithelial cell contacts with HMP-1 and HMR-1/cadherin; however, despite its normal role in embryonic cell adhesion, HMP-2 can activate transcription and when overexpressed in vivo, can partially rescue vulval defects produced by loss of BAR-1/beta-catenin, suggesting that HMP-2 has retained the ability to interact with the Wnt signaling pathway. WormBase CDS description: Armadillo/beta-catenin-like repeats (4 domains)
K05F1.7 K05F1.7 P W All gene names: msp-63; K05F1.7; 2G86; CE02811; MSP63_CAEEL; NM_062742; WBGene00003456; WP:CE02811 WormBase description: msp-63 encodes a protein that belongs to a family of proteins called the Major Sperm Proteins (MSPs) that is conserved in nematodes; this family consists of closely related, small, basic proteins that make up 15% of sperm protein; this multigene family consists of over fifty genes, including many pseudogenes; MSPs are involved in both extracellular signaling and cytoskeletal functions during reproduction-MSP antagonizes Eph/ephrin signaling, in part, by binding VAB-1 Eph receptor tyrosine kinase on oocytes and sheath cells to promote oocyte maturation and MAPK activation; MSPs assemble into fibrous networks that drive movement of the C. elegans sperm; msp genes are expressed only in late primary spermatocytes. WormBase CDS description: Major sperm protein
K06A5.4 K06A5.4 P W All gene names: K06A5.4; 1H39; CE26645; WBGene00019432; WP:CE26645
K06A5.7 K06A5.7 P W All gene names: cdc-25.1; lin-60; CDC25.1; K06A5.7; K06A5.7.1; K06A5.7.2; 1H46; CE11778; MPIP1_CAEEL; NM_059461; WBGene00000386; WP:CE11778 WormBase description: cdc-25.1 encodes a CDC25 phosphatase homolog that affects embryonic viability, meiosis, mitosis, proliferation of the intestine (E cell lineage), and germ line proliferation; it is expressed in the developing germline, in the nuclei of oocytes, embryonic nuclei, nuclei of embryonic cortical membranes, and sperm pronuclei, and in the germline precursors Z2 and Z3. WormBase CDS description: protein phosphatase
K06B4.9 K06B4.9 P W All gene names: srx-29; K06B4.9; 5Q174; CE36311; NM_074503; WBGene00005920; WP:CE36311 WormBase description: 7TM receptor, srx family
K06H6.2 K06H6.2 P W All gene names: K06H6.2; 5B63; CE11830; WBGene00019450; WP:CE11830
C14B9.4 K06H7.1 P W
K06H7.6 K06H7.6 P W All gene names: apc-2; K06H7.6; 3J171; ANC2_CAEEL; CE26943; NM_066361; WBGene00000143; WP:CE26943 WormBase description: apc-2 encodes an ortholog of subunit 2 of anaphase-promoting complex (APC, a cyclin-specific E3 RING ubiquitin ligase); APC-2 and S. cerevisiae's Apc2p have 32% identity in their cullin domains (considered crucial for function), but otherwise share no obvious similarity; inactivating apc-2 with RNAi causes embryos to arrest at the meiotic one-cell stage, implying that APC-2 is required for the metaphase-to-anaphase transition of meiosis I; this RNAi phenotype of apc-2 is shared by apc-1, apc-4, apc-11, cdc-16, cdc-23, and cdc-27; by analogy with other APC subunits with hypomorphic alleles, APC-2 is likely to be required for asymmetrical segregation of cell fate determinants in two-cell embryos.
K06H7.7 K06H7.7 P W All gene names: K06H7.7; 3J172; CE00258; WBGene00019458; WP:CE00258; YMX7_CAEEL
K07A1.5 K07A1.5 P W All gene names: K07A1.5; 1K167; CE11848; WBGene00010612; WP:CE11848
K07B1.7 K07B1.7 P W All gene names: K07B1.7; 5J826; CE29509; CE38846; WBGene00019467; WP:CE29509; WP:CE38846
K07C11.2 K07C11.2 P W All gene names: air-1; let-412; K07C11.2; K07C11.2.1; K07C11.2.2; 5I703; CE21025; NM_072718; Q21271_CAEEL; WBGene00000098; WP:CE21025 WormBase description: AIR-1 belongs to the Aurora-A family of serine/threonine kinases that localize to centrosomes; AIR-1 is required for embryonic survival, germline proliferation and development, locomotion, and vulval development; AIR-1 is required to recruit centrosomal gamma-tubulin during maturation; Aurora-A kinases are implicated in centrosome separation and spindle assembly. WormBase CDS description: protein kinase
K07C5.6 K07C5.6 P W All gene names: K07C5.6; K07C5.6.1; K07C5.6.2; 5K834; CE06116; WBGene00010629; WP:CE06116 WormBase description: Zinc finger, CCHC class
K07C5.8 K07C5.8 P W All gene names: cash-1; K07C5.8; 5K845; CE35585; WBGene00010631; WP:CE35585 WormBase description: nuclear autoantigen
K07E8.8 K07E8.8 P W All gene names: K07E8.8; 2A944; WBGene00023321
K07F5.13 K07F5.13 P W All gene names: npp-1; K07F5.13; K07F5.13b.1; K07F5.13b.2; 4K625; CE06127; CE23857; CE23858; NM_069369; NM_069370; NM_069371; WBGene00003787; WP:CE06127; WP:CE23857; WP:CE23858
K07F5.7 K07F5.7 P W All gene names: K07F5.7; 4K612; CE06122; WBGene00010635; WP:CE06122
K07F5.8 K07F5.8 P W All gene names: K07F5.8; 4K614; CE23859; WBGene00010636; WP:CE23859 WormBase description: protein-tyrosine phosphatase
K07H8.1 K07H8.1 P W All gene names: K07H8.1; 4J61; CE18021; WBGene00019503; WP:CE18021
K07H8.2 K07H8.2 P W All gene names: K07H8.2; K07H8.2b.1; K07H8.2b.2; K07H8.2c.1; K07H8.2c.2; K07H8.2c.3; 4J57; CE18022; CE28593; CE37721; WBGene00019504; WP:CE18022; WP:CE28593; WP:CE37721
K08A2.2 K08A2.F P W
K08D10.1 K08D10.1 P W All gene names: K08D10.1; 4E949; CE28596; P83384_CAEEL; WBGene00019528; WP:CE28596
K08E3.3 K08E3.3 P W All gene names: K08E3.3; 3O847; CE37123; CE37124; WBGene00010663; WP:CE37123; WP:CE37124 WormBase description: EF hand, Src homology domain 3
K08E3.6 K08E3.6 P W All gene names: cyk-4; K08E3.6; 3O858; CE18872; NM_067444; WBGene00000875; WP:CE18872 WormBase description: cyk-4 encodes a GTPase activating protein (GAP) for the Rho family of GTPases that, together with ZEN-4, is sufficient to promote the formation of the large bundles of microtubules that form the central spindle during anaphase, and is required for fertility and coordinated locomotion postembryonically; localizes to the central spindle during anaphase interdependently with ZEN-4, and interacts with ZEN-4 in vitro and in vivo. WormBase CDS description: Phorbol esters/diacylglycerol binding domain (C1 domain), GTPase-activator protein for Rho-like GTPases
K08E4.5 K08E4.5 P W All gene names: bath-37; K08E4.5; 4M835; CE03465; WBGene00010669; WP:CE03465
K08E7.3 K08E7.3 P W All gene names: let-99; K08E7.3; 4N335; CE06147; LET99_CAEEL; NM_070006; WBGene00002368; WP:CE06147 WormBase description: let-99 encodes a protein with a DEP domain (Domain found in Dishevelled, Egl-10, and Pleckstrin); LET-99 has no obvious homologs in non-nematodes, but has a truncated paralog (LRG-1) in C. elegans; LET-99 is required for the mitotic spindle to be properly oriented with respect to the axis of cellular polarity, both during anterior migration and rotation of the nuclear-centrosome complex and during anaphase; let-99 mutants exhibit hyperactive nuclear movement and abnormal anaphase spindle pole behavior; LET-99 is mislocalized in par-2 and par-3 mutants; like other proteins containing DEP domains, LET-99 may act as part of a G protein signalling pathway (e.g., the one controlling spindle position). WormBase CDS description: Domain found in Dishevelled, Egl-10, and Pleckstrin
K08F9.2 K08F9.2 P W All gene names: tag-216; K08F9.2; K08F9.2.1; K08F9.2.2; K08F9.2.3; 5P616; CE11944; WBGene00010685; WP:CE11944 WormBase description: beta-transducin like protein
K08F9.4 K08F9.4 P W All gene names: K08F9.4; 5P625; CE11948; WBGene00010687; WP:CE11948
K09C6.2 K09C6.2 P W All gene names: K09C6.2; 5B335; CE11990; WBGene00019556; WP:CE11990
K09C6.7 K09C6.7 P W All gene names: K09C6.7; 5B314; CE35338; WBGene00019561; WP:CE35338
K09D9.11 K09D9.11 P W All gene names: K09D9.11; 5E474; CE21065; WBGene00019568; WP:CE21065
K09E3.7 K09E3.7 P W All gene names: K09E3.7; CE04745; WBGene00019578; WP:CE04745; XR742
K09F6.3 K09F6.3 P W All gene names: K09F6.3; 2C551; CE31563; WBGene00019586; WP:CE31563 WormBase description: protein-tyrosine phosphatase
K09F6.4 K09F6.4 P W All gene names: K09F6.4; 2C552; CE12030; WBGene00019587; WP:CE12030
K09G1.2 K09G1.2 P W All gene names: K09G1.2; 5K71; CE12042; WBGene00010728; WP:CE12042
K10B2.1 K10B2.1 P W All gene names: lin-23; stu-1; K10B2.1; K10B2.1.1; K10B2.1.2; 2G663; CE28600; LIN23_CAEEL; NM_062884; WBGene00003009; WP:CE28600 WormBase description: lin-23 encodes an F-box- and WD-repeat-containing protein orthologous to Saccharomyces cerevisiae MET30 and human beta TRCP (OMIM:603482), both components of the SCF (Skp1, Cullin, F-box) ubiquitin-ligase complex that regulates ubiquitin-mediated protein degradation; LIN-23 negatively regulates postembryonic cell divsions in all tissue types, and specifically, has been shown to function cell autonomously in the vulva to negatively regulate cell cycle progression and allow for cell cycle exit; LIN-23 also functions cell autonomously in some neurons to regulate neurite outgrowth; LIN-23 expression is first detected broadly during gastrulation, with expression continuing postembryonically in body wall and enteric muscle, hypodermal cells, and many but not all neurons; LIN-23 localizes to the cytoplasm. WormBase CDS description: Transducin beta chain
K10B2.5 K10B2.5 P W All gene names: ani-2; tag-221; K10B2.5; 2G652; ANI2_CAEEL; CE02012; NM_062881; WBGene00019608; WP:CE02012
K10C3.5 K10C3.5 P W All gene names: K10C3.5; 1K443; CE32469; CE38396; WBGene00010732; WP:CE32469; WP:CE38396 WormBase description: elongation factor EF-2 like
K10C8.1 K10C8.1 P W All gene names: K10C8.1; 5N170; CE39514; WBGene00010734; WP:CE39514
K10D2.1 K10D2.1 P W All gene names: K10D2.1; 3G283; CE02013; CE39597; WBGene00019627; WP:CE02013; WP:CE39597
K10D2.2 K10D2.2 P W All gene names: K10D2.2; K10D2.2.1; K10D2.2.2; 3G277; CE27429; WBGene00019628; WP:CE27429
K10D2.3 K10D2.3 P W All gene names: K10D2.3; 3G269; CE02015; WBGene00019629; WP:CE02015
K10H10.7 K10H10.7 P W All gene names: K10H10.7; 2O792; CE16256; WBGene00010763; WP:CE16256
K11C4.1 K11C4.1 P W All gene names: K11C4.1; 5H377; CE12108; WBGene00019642; WP:CE12108 WormBase description: serine/threonine-protein kinase
K11H3.2 K11H3.2 P W All gene names: K11H3.2; 3K933; CE00262; WBGene00010779; WP:CE00262; YM42_CAEEL
K11H3.4 K11H3.4 P W All gene names: K11H3.4; 3K925; CE28606; WBGene00010781; WP:CE28606; YM44_CAEEL
K12D12.2 K12D12.2 P W All gene names: npp-3; K12D12.2; K12D12.2.1; K12D12.2.2; 2M156; CE02271; NM_064133; WBGene00003789; WP:CE02271 WormBase description: npp-3 encodes a predicted nucleoporin that is a homolog of vertebrate Nup205, and is required for normal nuclear pore complex distribution in the nuclear envelope, affects nuclear exclusion of large non-nuclear macromolecules, chromatin condensation, early embryonic viability, body integrity and locomotion.
M01A10.1 M01A10.1 P W All gene names: M01A10.1; 1G133; CE12226; WBGene00019692; WP:CE12226 WormBase description: M01A10.1 encodes a protein, belonging to an ancient family of single-stranded nucleic acid-binding proteins, that is predicted to regulate gene expression through binding either mRNA or (locally) single-stranded DNA; it is most likely to specifically bind one or more discrete mRNAs and regulate their spatial localization or alternative splicing. WormBase CDS description: DNA-binding protein
M01D1.3 M01D1.3 P W All gene names: M01D1.3; 2B314; CE23871; WBGene00019700; WP:CE23871
M01E11.2 M01E11.2 P W All gene names: M01E11.2; M01E11.2.1; M01E11.2.2; 1G149; CE12290; P91401_CAEEL; WBGene00019711; WP:CE12290
M01E11.3 M01E11.3 P W All gene names: M01E11.3; 1G143; CE12292; WBGene00019712; WP:CE12292
M01E11.6 M01E11.6 P W All gene names: klp-15; M01E11.6; 1G146; CE12298; NM_059232; P91400_CAEEL; WBGene00002225; WP:CE12298 WormBase description: kinesins
M02B7.1 M02B7.1 P W All gene names: M02B7.1; 4E571; CE12320; WBGene00019723; WP:CE12320
M03A1.1 M03A1.1 P W All gene names: vab-1; M03A1.1; 2E879; CE25060; CE28617; NM_062405; NM_062406; VAB1_CAEEL; WBGene00006868; WP:CE25060; WP:CE28617 WormBase description: tyrosine-protein kinase receptor
M03C11.3 M03C11.3 P W All gene names: M03C11.3; 3L503; CE03494; WBGene00010840; WP:CE03494
M03C11.4 M03C11.4 P W All gene names: M03C11.4; 3L496; CE03495; WBGene00010841; WP:CE03495
M03C11.7 M03C11.7 P W All gene names: M03C11.7; M03C11.7.1; M03C11.7.2; 3L514; CE03498; WBGene00010844; WP:CE03498
M03D4.1 M03D4.1 P W All gene names: klp-9; zen-4; M03D4.1; 4G885; CE12344; CE12346; CE31717; CE31718; Q8MQ04_CAEEL; WBGene00006974; WP:CE12344; WP:CE12346; WP:CE31717; WP:CE31718 WormBase description: zen-4 encodes a kinesin-like protein that is a member of the kinesin-6 subfamily of plus-end-directed microtubule motors; loss-of-function mutations and RNAi experiments indicate that ZEN-4 is required for completion of cytokinesis after mitosis and for polar body extrusion after meiotic divisions; during mitosis, ZEN-4 is detected at the spindle midzone where it co-localizes with spindle microtubules, and ZEN-4 persists at the midbody remnant once cell division is complete; ZEN-4 is also occasionally seen at centrosomes in interphase cells.
M03F8.3 M03F8.3 P W All gene names: phi-12; M03F8.3; 5G423; CE28622; WBGene00019762; WP:CE28622
M04F3.3 M04F3.3 P W All gene names: M04F3.3; 1F332; CE39108; Q95Y99_CAEEL; WBGene00019769; WP:CE39108 WormBase description: protein kinase
M05B5.1 M05B5.1 P W All gene names: M05B5.1; 1H754; CE06187; WBGene00010869; WP:CE06187 WormBase description: protein-tyrosine phosphatase
M05B5.5 M05B5.5 P W All gene names: hlh-2; M05B5.5; M05B5.5a.1; M05B5.5a.2; 1H768; CE06191; NM_059633; WBGene00001949; WP:CE06191 WormBase description: hlh-2 encodes a Class I basic helix-loop-helix (bHLH) transcription factor that is the C. elegans ortholog of the mammalian E and Drosophila Daughterless transcriptional activators; HLH-2 activity is required for cell fate specifications occuring during embryonic and larval development that affect such processes as gonadogenesis, male tail formation, and programmed cell death; HLH-2 has been shown to dimerize with at least two C. elegans Acheate-scute homologs, LIN-32, a neural-specific protein with which it functions in male tail development and HLH-3, with which it is coexpressed in the nuclei of embryonic neuronal prescursors and with which it regulates the transcription of the EGL-1 cell death activator in the NSM sister cells; in gonadogenesis, HLH-2 is required for bestowing proAC competence on the cells that undergo the AC/VU (anchor cell/ventral uterine precursor) cell fate decision, for specification, differentiation, and function of the distal tip cell (DTC) and AC, including transcriptional regulation of the LAG-2 Delta-like ligand in the latter, and for formation of the uterine seam cell (utse); genetic analysis also suggests that HLH-2 functions with HLH-14, an additional Acaete-scute homolog, to specify the PVQ/HSN/PHB neuroblast cell lineage; HLH-2 is expressed in all nuclei of early embryos until the ~200-cell stage, when expression becomes increasingly restricted to neuronal cells and their immediate precursors; later expression is detected in, but not limited to, pharyngeal cells, anterior neurons, vulval and uterine muscles, the DTCs, the presumptive and mature AC, the Q neuroblast, and enteric muscles; comparative analysis of transcriptional and translational reporters indicates that hlh-2 is expressed in both the anchor cell and the ventral uterine (VU) precursor, but that expression in the latter is subject to post-transcriptional down-regulation; HLH-2 accumulation in the presumptive AC is the first detectable difference between the AC and VU precursors during the lateral specification event that distinguishes these two cell fates. WormBase CDS description: transcription factor E2-A like
M05D6.3 M05D6.3 P W All gene names: M05D6.3; 2I767; CE03501; WBGene00010876; WP:CE03501 WormBase description: protein-tyrosine-phosphatase
M106.1 M106.1 P W All gene names: let-29; mix-1; smc-2; M106.1; R06F6.10; 2L131; CE18083; MIX1_CAEEL; NM_063930; WBGene00003367; WP:CE18083 WormBase description: The mix-1 gene encodes a homolog of SMC2 involved in chromosome segregation, X-chromosome gene regulation, and repression of X-linked genes during dosage compensation. WormBase CDS description: mitotic chromosome and X-chromosome associated MIX-1 protein
M117.4 M117.4 P W All gene names: M117.4; 4M596; CE18085; WBGene00010920; WP:CE18085
M151.7 M151.4 P W
M28.9 M28.9 P W All gene names: M28.9; M28.9.1; M28.9.2; 2K933; CE02287; WBGene00010900; WP:CE02287
M70.3 M70.3 P W All gene names: M70.3; 4D2; CE17195; CE25959; WBGene00019785; WP:CE17195; WP:CE25959
PAR2.4 PAR2.4 P W All gene names: pfc-1; PAR2.4; PAR2.4a.1; PAR2.4a.2; PAR2.4a.3; PAR2.4a.4; 3J854; CE00848; CE32699; CHSS2_CAEEL; NM_066533; NM_181942; WBGene00019802; WP:CE00848; WP:CE32699
R01H10.1 R01H10.1 P W All gene names: ccd-1; div-1; R01H10.1; 3L336; CE28840; DPOA2_CAEEL; NM_066867; WBGene00001002; WP:CE28840 WormBase description: div-1 encodes a homolog of the B subunit of the DNA polymerase alpha-primase complex; DIV-1 is required in embryos for the normal timing of interphase in cell divisions, and for the asymmetric distribution of PIE-1 and P granules. WormBase CDS description: DNA polymerase alpha associated subunit
R01H2.2 R01H2.2 P W All gene names: R01H2.2; 3I145; CE30097; WBGene00019810; WP:CE30097
R01H2.3 R01H2.3 P W All gene names: egg-2; R01H2.3; 3I146; CE00802; WBGene00019811; WP:CE00802
R01H2.4 R01H2.4 P W All gene names: R01H2.4; 3I148; CE38969; WBGene00019812; WP:CE38969
R02D3.4 R02D3.4 P W All gene names: R02D3.4; 4A986; CE18098; WBGene00019822; WP:CE18098
R02D3.5 R02D3.5 P W All gene names: R02D3.5; R02D3.5.1; R02D3.5.2; 4A992; CE18099; WBGene00019823; WP:CE18099 WormBase description: farnesyltransferase alpha subunit
R02E12.2 R02E12.3 P W
R03D7.5 R03D7.5 P W All gene names: R03D7.5; 2L239; CE35899; WBGene00010991; WP:CE35899; YRL5_CAEEL WormBase description: serine/threonine kinase
R03D7.7 R03D7.7 P W All gene names: nos-1; R03D7.7; 2L242; CE01614; NM_063957; WBGene00003783; WP:CE01614 WormBase description: nos-1 encodes an putative RNA-binding protein that contains a zinc-binding motif homologous to that of Drosophila Nanos, a posterior-group protein required for embryonic patterning and primordial germ cell development; in C. elegans, NOS-1 is required redundantly with NOS-2, a second Nanos homolog, for maintenance of germ cell viability during postembryonic development and for preventing primordial germ cells from dividing in the absence of food; nos-1 mRNA is expressed dynamically in the embryo, with early expression seen throughout the embryo and later expression restricted solely to germline blastomeres; nos-1 mRNA becomes undetectable after the 200-cell stage, but reappears later at the 550-cell stage; NOS-1 protein is not detectable in germline blastomeres until the 550-cell stage, suggesting that NOS-1 might actually function zygotically in germline specification. WormBase CDS description: nanos protein
R04D3.3 R04D3.3 P W All gene names: R04D3.3; R04D3.3.1; R04D3.3.2; CE06224; WBGene00011011; WP:CE06224; XN908
R05D3.2 R05D3.2 P W All gene names: R05D3.2; 3J463; CE00281; WBGene00019877; WP:CE00281; YNC2_CAEEL WormBase description: R05D3.2 is orthologous to the human gene UNKNOWN (PROTEIN FOR MGC:16889) (C7orf2; OMIM:605522), which when mutated leads to disease.
R05D3.3 R05D3.3 P W All gene names: R05D3.3; 3J453; CE00282; WBGene00019878; WP:CE00282; YNC3_CAEEL WormBase description: Zinc finger
R05D3.5 R05D3.5 P W All gene names: R05D3.5; 3J439; CE28272; WBGene00019879; WP:CE28272; YNC5_CAEEL
R05D7.2 R05D7.2 P W All gene names: R05D7.2; 1M757; CE16296; WBGene00011027; WP:CE16296
F54E2.3 R05D8.N P W
R05G9.3 R05G9.B P W
R05H5.2 R05H5.2 P W All gene names: cdc-25.4; R05H5.2; 2K476; CE02289; NM_063796; WBGene00000389; WP:CE02289 WormBase description: a homolog of dual specificity phosphatase Cdc25. WormBase CDS description: M-phase inducer phosphatase
R06A4.2 R06A4.2 P W All gene names: R06A4.2; R06A4.2.1; R06A4.2.2; 2O649; CE18109; WBGene00011047; WP:CE18109
R06C7.2 R06C7.2 P W All gene names: R06C7.2; 1H810; CE36661; WBGene00011062; WP:CE36661
R06C7.8 R06C7.8 P W All gene names: bub-1; R06C7.8; 1H831; CE06251; NM_059650; Q21776_CAEEL; WBGene00000275; WP:CE06251 WormBase description: bub-1 encodes a serine/threonine kinase orthologous to Saccharomyces cerevisiae BUB1 which is required for proper function of the mitotic spindle assembly checkpoint and human BUB1 (OMIM:602452) which is mutated in some colorectal cancers; BUB-1 activity is required at several stages of development, including embryogenesis; BUB-1 is expressed predominantly in the anterior of the embryo and in hypodermal seam cells during the L1 and L2 larval stages. WormBase CDS description: Eukaryotic protein kinase domain
R06F6.4 R06F6.4 P W All gene names: R06F6.4; 2L84; CE16303; WBGene00011068; WP:CE16303; YRM4_CAEEL
R07B7.2 R07B7.2 P W All gene names: R07B7.2; 5M540; CE38533; Q95QM1_CAEEL; WBGene00011087; WP:CE38533
R07B7.4 R07B7.4 P W All gene names: R07B7.4; 5M546; CE06266; WBGene00011088; WP:CE06266 WormBase description: Monooxygenase
R07E4.5 R07E4.5 P W All gene names: R07E4.5; CE04820; WBGene00019938; WP:CE04820; XG568
R07G3.3 R07G3.3 P W All gene names: npp-21; R07G3.3; 2H897; CE37543; CE37544; WBGene00019940; WP:CE37543; WP:CE37544 WormBase description: myosin heavy chain
R07G3.7 R07G3.7 P W All gene names: R07G3.7; R07G3.7b.1; R07G3.7b.2; 2H900; CE36004; CE36005; WBGene00019943; WP:CE36004; WP:CE36005; YRO7_CAEEL
R08C7.10 R08C7.10 P W All gene names: R08C7.10; 4F208; CE07433; CE28750; CE28751; WBGene00019953; WP:CE07433; WP:CE28750; WP:CE28751
R08C7.5 R08C7.5 P W All gene names: R08C7.5; 4F195; CE39611; WBGene00019949; WP:CE39611
R08C7.8 R08C7.8 P W All gene names: R08C7.8; 4F198; CE07431; WBGene00019951; WP:CE07431 WormBase description: serine/threonine protein phosphatase
R08D7.1 R08D7.1 P W All gene names: R08D7.1; 3K56; CE00289; WBGene00011142; WP:CE00289; YNE1_CAEEL
R08D7.3 R08D7.3 P W All gene names: eif-3.D; R08D7.3; 3K60; CE00291; IF37_CAEEL; NM_066583; WBGene00001227; WP:CE00291 WormBase description: eif-3.D encodes the C. elegans ortholog of the translation initiation factor 3 subunit d (eIF3d/Moe1); by homology, EIF-3.D is predicted to function as part of the eIF3 translation initiation complex but also as part of a Ras-mediated pathway that regulates mitotic spindle formation; in C. elegans, large-scale RNAi screens indicate that eif-3.D is required for embryonic and germline development, locomotion, and normal rates of post-embryonic growth; in the early embryo, eif-3.D is specifically required for the fidelity of meiotic divisions and normal pseudocleavage; eif-3.D function is likely conserved, as expression of eif-3.D in Schizosaccharomyces pombe can rescue the mitotic spindle and growth defects associated with moe1 mutant cells; to date, eif-3.D expression has been reported in anterior neurons and the pharynx, beginning at late stages of embryogenesis.
R09A8.1 R09A8.1 P W All gene names: R09A8.1; CE03537; WBGene00011152; WP:CE03537; XN231
R09A8.2 R09A8.2 P W All gene names: R09A8.2; CE34082; WBGene00011153; WP:CE34082; XN239
R09E10.4 R09E10.4 P W All gene names: R09E10.4; 4L70; CE36448; WBGene00011174; WP:CE36448 WormBase description: long-chain-fatty-acid-CoA ligase
R102.3 R102.3 P W All gene names: R102.3; 4L457; CE35600; WBGene00011290; WP:CE35600
R102.10 R102.7 P W
R107.4 R107.4 P W All gene names: R107.4; 3K136; CE31817; CE31818; CE31819; CE37846; WBGene00011299; WP:CE31817; WP:CE31818; WP:CE31819; WP:CE37846; YNH4_CAEEL WormBase description: tyrosine-protein kinase
R10D12.10 R10D12.10 P W All gene names: R10D12.10; 5O436; CE12690; WBGene00011191; WP:CE12690 WormBase description: serine/threonine kinase
R10E11.3 R10E11.3 P W All gene names: R10E11.3; R10E11.3a.1; R10E11.3a.2; 3K867; CE23922; CE23923; UBPX_CAEEL; WBGene00011216; WP:CE23922; WP:CE23923 WormBase description: Ubiquitin-specifc processing protease
R10E4.4 R10E4.4 P W All gene names: mcm-5; R10E4.4; R10E4.4.1; R10E4.4.2; 3F378; CE03558; MCM5_CAEEL; NM_065457; WBGene00003157; WP:CE03558 WormBase description: CDC46
R10F2.6 R10F2.6 P W All gene names: R10F2.6; 3E28; CE12712; WBGene00019997; WP:CE12712
R10H10.2 R10H10.2 P W All gene names: spe-26; R10H10.2; 4L154; CE06293; NM_069518; SPE26_CAEEL; WBGene00004972; WP:CE06293 WormBase description: spe-26 encodes a Kelch motif-containing protein similar to the Drosophila proteins kelch and diablo and the Limulus (horseshoe crab) actin-bundling protein scruin; SPE-26 activity is required for several processes including embryogenesis, spermatogenesis, thermotolerance, and regulation of lifespan; SPE-26 mRNA is detected in spermatogonial cells and spermatocytes, but not in spermatids. WormBase CDS description: MIPP repeats
R10H10.7 R10H10.7 P W All gene names: R10H10.7; R10H10.7.1; R10H10.7.2; 4L176; CE29819; WBGene00011225; WP:CE29819 WormBase description: tyrosine-protein kinase like
R119.1 R119.1 P W All gene names: R119.1; 1A832; CE25971; WBGene00020087; WP:CE25971
R11A5.1 R11A5.1 P W All gene names: apb-3; apt-6; R11A5.1; 1I433; CE12722; CE18132; NM_059769; NM_059770; WBGene00000163; WP:CE12722; WP:CE18132 WormBase description: apt-6 encodes an adaptin, orthologous to the beta3 subunit of adaptor protein complex 3 (AP-3); based on structural similarity, APT-6 may be involved in the formation of intracellular transport vesicles.
R11A8.1 R11A8.1 P W All gene names: R11A8.1; 4L120; CE06299; WBGene00011236; WP:CE06299
R11E3.7 R11E3.7 P W All gene names: dpf-7; R11E3.7; 4F564; CE19549; CE31721; NM_171328; NM_171329; WBGene00001060; WP:CE19549; WP:CE31721
R11H6.5 R11H6.5 P W All gene names: R11H6.5; 5P92; CE12778; WBGene00011253; WP:CE12778 WormBase description: Human NF45 protein like
R12E2.1 R12E2.1 P W All gene names: R12E2.1; R12E2.1.1; R12E2.1.2; 1E751; CE18133; WBGene00020030; WP:CE18133
R12E2.10 R12E2.10 P W All gene names: R12E2.10; 1E738; CE18142; WBGene00020035; WP:CE18142 WormBase description: protein-tyrosine phosphatase
R13A1.3 R13A1.3 P W All gene names: R13A1.3; 4H973; CE36605; WBGene00020042; WP:CE36605 WormBase description: degenerin
R13H4.4 R13H4.4 P W All gene names: hmp-1; R13H4.4; 5M331; CE25089; HMP1_CAEEL; NM_073584; WBGene00001978; WP:CE25089 WormBase description: alpha-catenin
R151.8 R151.8 P W All gene names: R151.8; 3I318; CE27201; WBGene00020111; WP:CE27201
R155.2 R155.2 P W All gene names: R155.2; 3D54; CE12864; WBGene00020116; WP:CE12864
R166.2 R166.2 P W All gene names: R166.2; R166.2.1; R166.2.2; 2K826; CE03581; Q22003_CAEEL; WBGene00011302; WP:CE03581
R166.4 R166.4 P W All gene names: pro-1; R166.4; 2K830; CE03583; NM_063870; WBGene00004185; WP:CE03583 WormBase description: pro-1 encodes a WD-repeat-containing protein that is orthologous to Saccharomyces cerevisiae IPI3; pro-1 activity is required for ribosome biogenesis and specifically, for efficient processing of intervening sequence 2 (ITS2) from rRNA intermediates during 26S rRNA maturation; during development, pro-1 is essential for larval growth, fertility, and normal cell division patterns; in addition, pro-1 is required cell autonomously in the somatic gonad for proper spatial and temporal regulation of germline development and proliferation; a pro-1 promoter::gfp fusion construct reveals that pro-1 is widely expressed in the embryo as well as in every major post-embryonic lineage including the somatic gonad.
R186.7 R186.4 P W
T01C3.1 T01C3.1 P W All gene names: T01C3.1; 5P468; CE12908; WBGene00011318; WP:CE12908 WormBase description: WD domain, G-beta repeats
T01C3.3 T01C3.3 P W All gene names: T01C3.3; 5P472; CE12912; Q22055_CAEEL; WBGene00011320; WP:CE12912 WormBase description: Zinc finger, C3HC4 type (RING finger)
T01G9.4 T01G9.4 P W All gene names: kup-2; npp-2; T01G9.4; 1I868; CE06341; NM_059855; WBGene00003788; WP:CE06341 WormBase description: npp-2 encodes a protein with low similarity to rat nucleoporin Nup75 that affects embryonic viability and has a variety of other defects in RNAi screens including: nuclear morphology, growth, fertility, locomotion, and egg laying; enriched in oocytes.
T01G9.5 T01G9.5 P W All gene names: mei-1; T01G9.5; 1I871; CE06342; CE32479; MEI1_CAEEL; NM_059856; NM_181993; WBGene00003183; WP:CE06342; WP:CE32479 WormBase description: mei-1 encodes, by alternative splicing, two slightly different isoforms of an ortholog of the catalytic subunit of katanin (OMIM:606696) that is required for oocyte meiotic spindle formation, for stable association of the meiosis I spindle with the oocyte cortex, and for microtubule severing; MEI-1 exists in a physical complex with MEI-2 at the polar ends of meiotic spindle microtubules and meiotic chromatin; MEI-1 must be inactivated for meiosis to give way to mitosis, and ectopic expression of MEI-1/MEI-2 during mitosis is normally lethal; MEI-1 is bound by the BTB protein MEL-26 (both in vivo and in vitro), which physically links MEI-1 to CUL-3 (an E3 ubiquitin ligase); CUL-3, in turn, promotes MEI-1 proteolysis by the 26S proteasome during the transition from meiosis to mitosis; the MEI-1/MEI-2 complex requires tubules containing the germline-enriched beta tubulin TBB-2 in vivo, but does not require tubules made from TBB-2's (superficially) redundant paralog TBB-1.
T01H3.4 T01H3.4 P W All gene names: T01H3.4; T01H3.4.1; T01H3.4.2; 2I173; CE03598; WBGene00011350; WP:CE03598 WormBase description: T01H3.4 encodes an unfamiliar protein; T01H3.4 and T01H3.5 share an operon divergently transcribed from another operon containing vha-4.
T02E1.2 T02E1.2 P W All gene names: T02E1.2; 1I796; CE32480; WBGene00011375; WP:CE32480
T02E1.7 T02E1.7 P W All gene names: T02E1.7; 1I784; CE13058; WBGene00011379; WP:CE13058; YFC7_CAEEL WormBase description: Yeast hypothetical protein YG5Y like
T02G5.11 T02G5.11 P W All gene names: T02G5.11; 2H370; CE37039; WBGene00020167; WP:CE37039
T02G5.12 T02G5.12 P W All gene names: T02G5.12; 2H386; CE04864; WBGene00020168; WP:CE04864
T03F6.2 T03F6.2 P W All gene names: dnj-17; T03F6.2; 3O480; CE16336; NM_067358; WBGene00001035; WP:CE16336 WormBase description: This gene encodes a protein containing a DnaJ ('J') domain. WormBase CDS description: DnaJ, prokaryotic heat shock protein, Zinc finger, C2H2 type
T04A11.6 T04A11.6 P W All gene names: blm-1; him-6; T04A11.6; 4N259; BLM_CAEEL; CE31724; NM_069989; WBGene00001865; WP:CE31724 WormBase description: him-6 encodes a RecQ-like ATP-dependent DNA helicase orthologous to human BLM (OMIM:604610, mutated in Bloom syndrome); HIM-6 is required for normal levels of recombination during meiosis and as such, loss of HIM-6 function results in an increased frequency of genotypically XO males and inviable aneuoploid embryos as a result of higher levels of chromosome nondisjunction; HIM-6 interacts both genetically and in vitro with TOP-3, DNA topoisomerase IIIalpha, with which it functions to regulate genomic stability during germ-line mitosis; HIM-6 is expressed primarily in the germ line. WormBase CDS description: helicase
T04A6.3 T04A6.3 P W All gene names: T04A6.3; 3I694; CE00840; WBGene00020202; WP:CE00840
T04A8.13 T04A8.13 P W All gene names: T04A8.13; 3F797; CE23943; WBGene00011414; WP:CE23943 WormBase description: neurofilament triplet M protein
T04A8.15 T04A8.15 P W All gene names: T04A8.15; 3F802; CE33538; WBGene00011415; WP:CE33538 WormBase description: glucose-6-phosphate 1-dehydrogenase
T04A8.8 T04A8.8 P W All gene names: T04A8.8; 3F783; CE01077; WBGene00011410; WP:CE01077
T04D3.1 T04D3.1 P W All gene names: T04D3.1; 1N894; CE13153; WBGene00011431; WP:CE13153
T04F3.3 T04F3.3 P W All gene names: T04F3.3; 5M241; CE06358; WBGene00011438; WP:CE06358 WormBase description: protein tyrosine phosphatase
T05A12.3 T05A12.3 P W All gene names: T05A12.3; 4H648; CE04898; WBGene00020234; WP:CE04898
T05A7.6 T05A7.6 P W All gene names: T05A7.6; 2E960; CE04892; WBGene00020223; WP:CE04892 WormBase description: casein kinase
T05C12.1 T05C12.1 P W All gene names: T05C12.1; 2I461; CE02312; WBGene00011466; WP:CE02312 WormBase description: serine/threonine kinase
T05C12.6 T05C12.6 P W All gene names: mig-5; T05C12.6; 2I474; CE02318; CE25100; CE28076; Q22227_CAEEL; WBGene00003241; WP:CE02318; WP:CE25100; WP:CE28076 WormBase description: mig-5 encodes one of three C. elegans Dishevelled homologs; as part of both canonical and non-canonical Wnt signaling pathways, mig-5 activity is required maternally and embryonically for cell migration, cell fate specification, and proper spindle orientation in the early embryo; cells affected by mig-5 mutations include the distal tip cells (DTCs), the QL neuroblast descendants (QL.d), the vulval precursor cells, and the P12 ectoblast; in the early embryo, MIG-5 functions downstream of MOM-2/Wnt and MOM-1/Porc, and redundantly with two other Dishevelled homologs, DSH-1 and DSH-2, in a non-canonical Wnt pathway that specifies the endoderm cell fate and regulates mitotic spindle orientation in the EMS and ABar blastomeres; in posteriorly directed QL.d migrations, MIG-5 functions downstream of EGL-20/Wnt and upstream of PRY-1/Axin in a canonical Wnt pathway to positively regulate Wnt signaling and effect MAB-5 expression in QL.d; a mig-5::GFP fusion is reportedly expressed in many cells in the embryo, migrating DTCs, P cells, and the nerve ring. WormBase CDS description: presynaptic density protein (PSD-95) repeat-like domain
T05D4.5 T05D4.5 P W All gene names: T05D4.5; 3O671; CE16345; WBGene00011478; WP:CE16345
T05E11.4 T05E11.4 P W All gene names: spo-11; T05E11.4; 4L888; CE06363; NM_069680; SPO11_CAEEL; WBGene00004985; WP:CE06363 WormBase description: spo-11 encodes an ortholog of Spo11p in S. cerevisiae that is required for meiotic DNA recombination, and (in conjunction with CHK-2 and MRE-11) for the localization of RAD-51 to foci in late zygotene/early pachytene nuclei; like its yeast ortholog, SPO-11 is related to a subunit of archaebacterial topoisomerase VI, and probably causes double-stranded DNA breaks through a topoisomerase-like transesterase mechanism; however, unlike Spo11p, SPO-11 is dispensable for homologous synapsis and formation of the synaptonemal complex; SPO-11 is active even in syp-1 mutants where its double-stranded breaks cannot be correctly processed; spo-11 is transcribed in the germline.
T05E8.1 T05E8.1 P W All gene names: T05E8.1; 1G22; CE13241; WBGene00020262; WP:CE13241
T05F1.1 T05F1.1 P W All gene names: T05F1.1; T05F1.1.1; T05F1.1.2; 1K197; CE13267; WBGene00011488; WP:CE13267
T05F1.2 T05F1.2 P W All gene names: T05F1.2; 1K199; CE18929; WBGene00011489; WP:CE18929
T05G5.2 T05G5.2 P W All gene names: hlh-4; T05G5.2; 3K828; CE00314; HLH4_CAEEL; NM_066749; WBGene00001951; WP:CE00314 WormBase description: Achaete-scute/HLH
T05G5.9 T05G5.9 P W All gene names: T05G5.9; 3K848; CE34088; CE34089; WBGene00011503; WP:CE34088; WP:CE34089; YNP9_CAEEL WormBase description: Coiled coil protein
T05H10.4 T05H10.4 P W All gene names: T05H10.4; T05H10.4.1; T05H10.4.2; 2I343; CE01641; WBGene00011509; WP:CE01641; YRS4_CAEEL
T05H4.11 T05H4.11 P W All gene names: T05H4.11; 5G904; CE27440; WBGene00020274; WP:CE27440
T06C12.5 T06C12.5 P W All gene names: T06C12.5; 5Q347; WBGene00011514
T06D4.3 T06D4.3 P W All gene names: T06D4.3; 2D678; CE36012; WBGene00020292; WP:CE36012 WormBase description: T06D4.3 encodes a neprilysin; neprilysins are thermolysin-like zinc metallopeptidases, found on the outer surface of animal cells, that negatively regulate small signalling peptides (e.g., enkephalin, tachykinin, insulin, and natriuretic peptides) by cleaving them; T06D4.3 has no clear orthologs in other organisms.
T06D8.8 T06D8.8 P W All gene names: rpn-9; T06D8.8; T06D8.8.1; T06D8.8.2; 2L528; CE02329; NM_064004; WBGene00004465; WP:CE02329 WormBase description: rpn-9 is predicted to encode a non-ATPase subunit of the 19S regulatory complex of the proteasome that that affects body morphology, embryonic viability, locomotion, larval viability, fertility, and growth; interacts with RPN-11 in yeast two-hybrid assays.
T07A9.8 T07A9.8 P W All gene names: T07A9.8; 4B151; CE17217; WBGene00020296; WP:CE17217
T07C4.10 T07C4.10 P W All gene names: T07C4.10; 3L413; CE38103; NM_066880; WBGene00011562; WP:CE38103
T07F8.3 T07F8.3 P W All gene names: gld-3; T07F8.3; T07F8.3b.1; T07F8.3b.2; 2H427; CE28651; CE28652; NM_063078; NM_063079; Q95ZK7_CAEEL; WBGene00001597; WP:CE28651; WP:CE28652
T07G12.11 T07G12.10, T07G12.11 P W All gene names: zim-3; T07G12.11; 4L325; CE21166; WBGene00011601; WP:CE21166 WormBase description: Zinc finger, C2H2 type
T07G12.11 T07G12.10, T07G12.11 P W All gene names: zim-3; T07G12.11; 4L325; CE21166; WBGene00011601; WP:CE21166 WormBase description: Zinc finger, C2H2 type
T08A11.2 T08A11.2 P W All gene names: phi-11; T08A11.2; 3F354; CE03641; WBGene00011605; WP:CE03641
T08A9.4 T08A9.4 P W All gene names: T08A9.4; CE35761; WBGene00020336; WP:CE35761; XH933b WormBase description: This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins.
T08B6.9 T08B6.5 P W
T08D10.2 T08D10.2 P W All gene names: T08D10.2; CE33174; WBGene00011615; WP:CE33174; XM569 WormBase description: T08D10.2 encodes an ortholog of the human histone demethylase LSD1 (KIAA0601), and a paralog of C. elegans SPR-5; similar histone demethylase homologs are found in human, mouse, Drosophila, fission yeast, and Arabidopsis; T08D10.2 is predicted to demethylate histone H3 lysine 4 residues and act as a transcriptional corepressor. WormBase CDS description: corticosteroid-binding protein
T08D2.3 T08D2.3 P W All gene names: T08D2.3; CE29051; WBGene00011608; WP:CE29051; XA810
T09A12.4 T09A12.4 P W All gene names: nhr-66; T09A12.4; T09A12.4a.1; T09A12.4a.2; T09A12.4a.3; T09A12.4a.4; T09A12.4d.1; T09A12.4d.2; 4I992; CE31061; CE31062; CE31063; CE37723; NM_171396; NM_171397; NM_171398; Q8MXH2_CAEEL; WBGene00003656; WP:CE31061; WP:CE31062; WP:CE31063; WP:CE37723 WormBase description: nhr-66 encodes a member of the superfamily of nuclear receptors, which is one of the most abundant class of transcriptional regulators; nuclear receptors have a well conserved DNA binding domain and a less conserved C-terminal ligand binding domain; expression studies using GFP fusions indicate that nhr-66 is expressed in several neuronal and nonneuronal cells; microarray analysis indicates that expression of nhr-66 in neurons and seam cells is upregulated in response to exposure to cholesterol.
T09B4.10 T09B4.10 P W All gene names: chn-1; tag-69; T09B4.10; T09B4.10.1; T09B4.10.2; 1G758; CE29991; NM_059380; WBGene00000500; WP:CE29991 WormBase description: chn-1 encodes an ortholog of mammalian carboxyl-terminus of Hsc70 interacting protein (CHIP), an E4 ubiquitin-chain elongation factor; chn-1 is ubiquitously expressed; chn-1(by155) mutants are viable and superficially normal, but have reduced fertility and arrest as larvae if subjected to heat shock; chn-1 overexpression causes either embryonic lethality (if strong) or defective egg-laying and locomotion, along with constitutive dauer formation (if weak); chn-1(by155) mutations suppress viable unc-45(e286ts) and unc-45(m94ts) mutations, but not lethal unc-45(st604) ones; chn-1(by155) mutants, unlike wild-type, show defective sarcomeres if overexpressing unc-45 from a extrachromosomal array; CHN-1 binds the ubiquitin conjugating enzyme UFD-2, which in turn binds the Hsp90 cochaperone UNC-45; UNC-45 is a substrate for CHN-1- and UFD-2-dependent multiubiquitination; the parkin ortholog PDR-1 binds CHN-1, and requires CHN-1 for self-ubiquitination; chn-1(RNAi) animals accumulate abnormally phosphorylated tau proteins.
T09B9.5 T09B9.5 P W All gene names: T09B9.5; CE01653; WBGene00011646; WP:CE01653; XK397; YRU5_CAEEL
T09F5.2 T09F5.2 P W All gene names: T09F5.2; 5P631; CE13523; WBGene00011666; WP:CE13523
T09F5.3 T09F5.3 P W All gene names: str-45; T09F5.3; 5P641; CE16375; NM_074341; WBGene00006110; WP:CE16375
T10B11.7 T10B11.7 P W All gene names: T10B11.7; 1H522; CE34365; CE39770; WBGene00020403; WP:CE34365; WP:CE39770
T10C6.10 T10C6.10 P W All gene names: T10C6.10; 5Q517; CE16385; WBGene00011691; WP:CE16385 WormBase description: This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins.
T10C6.3 T10C6.3 P W All gene names: srx-43; T10C6.3; 5Q495; CE36322; NM_074621; WBGene00005934; WP:CE36322 WormBase description: 7TM receptor, srx family
T10C6.7 T10C6.7 P W All gene names: T10C6.7; 5Q510; CE16382; WBGene00011689; WP:CE16382 WormBase description: This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins.
T10C6.9 T10C6.9 P W All gene names: T10C6.9; 5Q514; WBGene00011690
T10F2.3 T10F2.3 P W All gene names: ulp-1; T10F2.3; 3G256; CE33694; NM_065694; SENP_CAEEL; WBGene00006736; WP:CE33694
T10G3.5 T10G3.5 P W All gene names: eea-1; T10G3.5; 5N972; CE31066; CE37989; EEA1; NM_073946; WBGene00011696; WP:CE31066; WP:CE37989 WormBase description: endosomal protein P162 like
T11F8.1 T11F8.1 P W All gene names: T11F8.1; 4G243; CE17234; WBGene00020433; WP:CE17234
T11F8.3 T11F8.3 P W All gene names: rme-2; T11F8.3; 4G237; CE22368; NM_068414; WBGene00004374; WP:CE22368 WormBase description: LDL-like receptor
T11G6.5 T11G6.5 P W All gene names: T11G6.5; 4L602; CE32932; WBGene00011720; WP:CE32932
T12E12.1 T12E12.1 P W All gene names: T12E12.1; T12E12.1.1; T12E12.1.2; 4G323; ARI2_CAEEL; CE31725; WBGene00020462; WP:CE31725
T12E12.2 T12E12.2 P W All gene names: T12E12.2; T12E12.2.1; T12E12.2.2; 4G311; CE13585; WBGene00020463; WP:CE13585
T12E12.4 T12E12.4 P W All gene names: drp-1; T12E12.4; T12E12.4a.1; T12E12.4a.2; 4G305; CE30172; CE30173; NM_171344; Q8WQC9_CAEEL; WBGene00001093; WP:CE30172; WP:CE30173 WormBase description: drp-1 encodes a dynamin-related protein, orthologous to Dnm1p in S. cerevisiae and DRP1 in mammals, that is required for severing of the mitochondrial outer membrane during mitochondrial division.
T13F2.6 T13F2.6 P W All gene names: T13F2.6; 4K545; CE13629; WBGene00011746; WP:CE13629
T13F2.7 T13F2.7 P W All gene names: T13F2.7; 4K540; CE13631; WBGene00011747; WP:CE13631
T13H10.1 T13H10.1 P W All gene names: kin-5; T13H10.1; 4K732; CE06444; NM_069392; WBGene00002193; WP:CE06444 WormBase description: kin-5 encodes a predicted protein tyrosine kinase that is most closely related to the non-receptor tyrosine kinases Fes/Fps and Fer that contain an SH2 domain and a tyrosine kinase domain (OMIM:190030, murine Fes appears to be required for hemopoietic homeostasis); as loss of kin-5 activity via large-scale RNAi screens does not result in any obvious abnormalities, the precise role of kin-5 in C. elegans development and/or behavior is not yet known. WormBase CDS description: Src homology domain 2, tyrosine-protein kinase (FES/FPS subfamily)
T14G10.6 T14G10.6 P W All gene names: tsp-12; T14G10.6; 4K914; CE06452; NM_069452; WBGene00006638; WP:CE06452 WormBase description: tetraspanin
T14G10.7 T14G10.7 P W All gene names: T14G10.7; T14G10.7.1; T14G10.7.2; 4K912; CE06453; WBGene00011776; WP:CE06453
T15B7.15 T15B7.15 P W All gene names: T15B7.15; 5H318; CE13674; WBGene00020527; WP:CE13674
T16G12.5 T16G12.5 P W All gene names: T16G12.5; 3L157; CE23986; WBGene00011806; WP:CE23986
T16G12.6 T16G12.6 P W All gene names: T16G12.6; 3L165; CE00584; WBGene00011807; WP:CE00584
T16H12.1 T16H12.1 P W All gene names: T16H12.1; 3L173; CE00322; WBGene00011811; WP:CE00322; YNV1_CAEEL
C24F3.5 T17B5.1 P W
T18D3.4 T18D3.4 P W All gene names: myo-2; T18D3.4; CE31619; MYO2_CAEEL; NM_077691; WBGene00003514; WP:CE31619; XN91 WormBase description: myo-2 encodes a muscle-type specific myosin heavy chain isoform; myo-2 is expressed in pharyngeal muscle.