Fox et al 2005, S14/T2 Exocytosis and Neurotransm, 16 genes Gene list file name: Fox2005_S14-T2_unc-4_neuron-transcript_Neurotransm Type of gene identifier: Cosmid name Description: Fox et al 2005 Additional File 14/Table2: Summary of unc-4::GFP enriched and expressed (EGs) transcripts in selected categories. This file is an expanded version of Table 2 (see text) in which EGs are added to the list of enriched genes. Genes are organized as in Table 2 according to molecular function (KOG description, other description http://www.wormbase.org). Statistical rank is indicated for each enriched transcript and "EG" designates transcripts that are EGs. Organism: Caenorhabditis elegans (nematode) Gene list type: Experimental Gene name Source Gene ID All gene names WormBase description WormBase CDS description Proteome description Member of lists (Publications) Other annotations C02H7.3 C02H7.3 aex-3; C02H7.3; CE16806; CE30850; MADD_CAEEL; NM_171618; WBGene00000086; WP:CE16806; WP:CE30850; XB370 The aex-3 gene encodes a guanine nucleotide exchange factor for the rab-3 GTPase that is orthologous to human MAP kinase activating protein containing death domain (MADD, OMIM:603584); AEX-3 is required for intracellular vesicle trafficking as well as synaptic vesicle release and interacts with CAB-1 and RAB-3 to regulate separate pathways for neural activities such as defecation and male mating, respectively; AEX-3 is also required for egg laying and locomotion; AEX-3 is expressed in nearly all neurons. DH11.4 DH11.4 DH11.4; 2I285; CE36121; WBGene00008437; WP:CE36121 synaptotagamin carboxyl terminus F31E8.2 F31E8.2 ric-2; snt-1; unc-121; F31E8.2; 2H105; CE02711; CE28229; NM_062993; SYT1_CAEEL; WBGene00004921; WP:CE02711; WP:CE28229; syt1 Synaptotagmin F45E4.3 F45E4.3 F45E4.3; F45E4.3b.1; F45E4.3b.2; 4I391; CE24980; CE24981; WBGene00018468; WP:CE24980; WP:CE24981 F55A4.1 F55A4.1 F55A4.1; F55A4.1.1; F55A4.1.2; CE19895; WBGene00018853; WP:CE19895; XB655 vesicle trafficking protein sec22b M142.1 M142.1 unc-119; M142.1; 3L997; CE06203; NM_066998; UN119_CAEEL; WBGene00006843; WP:CE06203 unc-119 encodes a novel protein that is highly conserved amongst metazoans; unc-119 activity is required for proper development of the nervous system, including axonal branching and fasciculation, and hence, for normal movement, chemosensation, and feeding; unc-119 is expressed pan-neuronally beginning in the early embryo (~60 cells) and continuing through adulthood; although the molecular function of UNC-119 is not yet known, human UNC119, which can rescue C. elegans unc-119 mutant animals, is reported to function as a receptor-associated activator of signal transduction; thus, UNC-119 may be part of a signal transduction pathway that mediates axonal patterning in response to external developmental cues. T08A9.3 T08A9.3 sng-1; T08A9.3; CE21167; NM_076838; SNG1_CAEEL; WBGene00004912; WP:CE21167; XH947; sng1 synaptogyrin T23H2.2 T23H2.2 snt-4; T23H2.2; 1H17; CE30456; NM_059452; P91493_CAEEL; WBGene00004924; WP:CE30456 C2 domain protein Y22F5A.3 Y22F5A.3 ric-4; snap-25; Y22F5A.3; 5K742; CE32008; NM_073240; WBGene00004364; WBGene00012495; WP:CE32008 Y22F5A.3 encodes an ortholog of vertebrate SNAP-25 and S. cerevisiae Sec9p; SNAP-25 is associated with synaptosomes, required for axonal growth in vivo, and targeted by botulinum neurotoxins; UNC-86 and MEC-3 are required for Y22F5A.3 expression, and act on a regulatory element (I2h) in Y22F5A.3 conserved between the first introns of C. elegans and C. briggsae Y22F5A.3 genes; other conserved motifs in the promoter region (P1 and P2) and first intron (I1h, I1m, I2h, and I2m) are required for Y22F5A.3 expression in DA and DD motor neurons (P1), DB and DA neurons (I1m and I2m), amphid and phasmid neurons (P2), pharyngeal neurons (I1h), and mechanosensory neurons (I2h); Y22F5A.3 has no obvious function in mass RNAi assays SNAP-25 family Y38C1BA.2 Y38C1BA.2 snn-1; Y38C1BA.2; 4C570; CE28520; CE31645; NM_171276; NM_171277; WBGene00004913; WP:CE28520; WP:CE31645; syn Y59A8B.8 Y59A8B.8 Y59A8B.8; 5S542; CE24502; WBGene00013345; WP:CE24502 gamma-soluble NSF attachment protein (SNAP-gamma)