|Gene list file name:||Fox2005_S14-T2_unc-4_neuron-transcript_G-protein-s|
|Type of gene identifier:||Cosmid name|
|Description:||Fox et al 2005 Additional File 14/Table2: Summary of unc-4::GFP enriched and expressed (EGs) transcripts in selected categories. This file is an expanded version of Table 2 (see text) in which EGs are added to the list of enriched genes. Genes are organized as in Table 2 according to molecular function (KOG description, other description http://www.wormbase.org). Statistical rank is indicated for each enriched transcript and "EG" designates transcripts that are EGs.|
|Organism:||Caenorhabditis elegans (nematode)|
|Gene list type:||Experimental|
Gene name Source Gene ID Annotation Date Added by
B0348.4 B0348.4 P W All gene names: egl-8; pbo-2; B0348.4; 5A521; CE30588; CE30589; CE36909; WBGene00001177; WP:CE30588; WP:CE30589; WP:CE36909 WormBase description: egl-8 encodes a phospholipase C beta homolog that affects pharyngeal pumping, defecation, and activity levels; it is genetically downstream of egl-30 with respect to aldicarb-induced paralysis, and is expressed in most or all neurons, with the strongest staining in the head and tail ganglia, and in the intestine.
C05B5.7 C05B5.7 P W All gene names: rgs-1; C05B5.7; 3L104; CE27794; NM_066820; RGS1_CAEEL; WBGene00004344; WP:CE27794 WormBase description: rgs-1 encodes a regulator of G protein signaling; by homology, RGS-1 is predicted to function as a GTPase-activating protein for heterotrimeric G-protein alpha-subunits, and in vitro RGS-1 can stimulate the GTPase activity of purified GOA-1; in vivo, rgs-1 appears to function redundantly with rgs-2 to regulate egg-laying behavior when animals are refed following starvation; rgs-1 is expressed in most or all neurons. WormBase CDS description: 1r20 protein (human)
C09E10.2 C09E10.2 P W All gene names: dgk-1; sag-1; C09E10.2; CE08038; CE08039; CE38268; CE38269; CE38270; NM_075789; NM_075790; WBGene00000958; WP:CE08038; WP:CE08039; WP:CE38268; WP:CE38269; WP:CE38270; XB604 WormBase description: The dgk-1 gene encodes an ortholog of diacylglyerol kinase that affects movement, egg laying, and synaptic transmission; it genetically interacts with the goa-1 and egl-30 signaling pathways, and is expressed in neurons.
C16C2.2 C16C2.2 P W All gene names: eat-16; sag-2; C16C2.2; C16C2.2a.1; C16C2.2a.2; 1K301; CE17404; CE30491; NM_170911; NM_170912; WBGene00001145; WP:CE17404; WP:CE30491 WormBase description: The eat-16 gene encodes an RGS protein that affects movement, pharyngeal pumping, egg laying, and synaptic transmission; it genetically interacts with the egl-30 and goa-1 signaling pathways, and is expressed in excitable cells and in the spermatheca. WormBase CDS description: regulator of G-protein signalling
C17F4.6 C17F4.6 P W All gene names: gcy-19; C17F4.6; 2D542; CE36790; NM_062090; WBGene00001544; WP:CE36790 WormBase description: gcy-19 encodes a predicted transmembrane guanylyl cyclase; as loss of gcy-19 activity via RNA-mediated interference does not result in any abnormalities, the precise role of GCY-19 in C. elegans development and/or behavior is not yet known; by sequence similarity, however, GCY-19 can be predicted to function in chemosensory signal transduction. WormBase CDS description: guanylate cyclase
C24A8.4 C24A8.4 P W All gene names: tag-306; C24A8.4; CE39226; WBGene00016038; WP:CE39226; XE950
C50H2.2 C50H2.2 P W All gene names: egl-47; gur-1; C50H2.2; 5K389; CE05480; CE36586; WBGene00001211; WP:CE05480; WP:CE36586 WormBase description: egl-47 encodes two seven transmembrane G-protein-coupled receptors; while loss-of-function mutations in egl-47 result in no detectable egg-laying defects, gain-of-function mutations and overexpression studies suggest that EGL-47 is required for negatively regulating activity of the hermaphrodite-specific motor neurons (HSNs) that control egg laying; EGL-47::GFP reporters made with either of the two isoforms indicate that EGL-47 is expressed in a small subset of head neurons, the HSNs, and the PVQ tail interneurons; in addition, a reporter made with the longer isoform, EGL-47A, is expressed in vulval cells in L4 larvae; in adults, the only cells of the egg-laying system that express EGL-47 are the HSNs; genetic and overexpression studies suggest that, in the HSNs, EGL-47 signals through the G-alpha protein GOA-1 to inhibit egg laying.
F17C8.1 F17C8.1 P W All gene names: acy-1; sgs-1; F17C8.1; 3F819; CE00955; NM_065569; WBGene00000068; WP:CE00955 WormBase description: The acy-1 gene encodes a protein with 40% identity to mammalian adenylyl cyclases, most closely related to the divergent mouse isoform type IX, that affects viability, muscle contraction, locomotion, and molting; it acts genetically downstream of gsa-1 and is expressed in excitable cells. WormBase CDS description: adenylate cyclase
F28C1.2 F28C1.2 P W All gene names: egl-10; F28C1.2; 5M936; CE24928; EGL10_CAEEL; NM_073724; WBGene00001179; WP:CE24928 WormBase description: egl-10 encodes an RGS protein, expressed in neurons, that affects egg laying and negatively regulates GOA-1 (Galpha[o]) signalling; it requires the Gbeta(5) ortholog GPB-2 for this activity, and genetically interacts with the egl-30 and goa-1 signaling pathways. WormBase CDS description: G-protein beta subunit GPB-2
F39B2.8 F39B2.8 P W All gene names: F39B2.8; CE30529; WBGene00009558; WP:CE30529
F57F5.5 F57F5.5 P W All gene names: kin-13; pkc-1; ttx-4; F57F5.5; F57F5.5.1; F57F5.5.2; 5M496; CE29092; KPC1B_CAEEL; NM_073613; WBGene00004032; WP:CE29092 WormBase description: pkc-1 encodes a serine/threonine protein kinase that is orthologous to mammalian protein kinase C epsilon (PRKCE), a member of the nPKC subgroup of the protein kinase C superfamily; together with UNC-13, PKC-1 may act downstream of goa-1 to modulate phorbol ester-induced stimulation of acetylcholine release at NMJs; PKC-1 positively regulates locomotion, and affects thermotaxis and chemotaxis together with kin-11; PKC-1 is required for regulating several behaviors including sensation of volatile and soluble compounds, osmolarity, and temperature (thermosensation); PKC-1 is also required for phorbolester-induced stimulation of acetylcholine release at neuromuscular junctions; PKC-1 localizes to the processes and cell bodies of approximately 75 sensory neurons and interneurons, and pkc-1 mRNA is detectable at varying levels during larval and adult stages. WormBase CDS description: Phorbol esters / diacylglycerol binding domain (2 domains), Protein kinase C terminal domain
R07E4.6 R07E4.6 P W All gene names: kin-2; R07E4.6; CE28749; CE39609; KAPR_CAEEL; NM_076598; WBGene00002190; WP:CE28749; WP:CE39609; XG588 WormBase description: kin-2 encodes a predicted regulatory subunit of a cAMP-dependent protein kinase that may act downstream of, or in parallel to, ric-8.
Y69A2AR.2 Y69A2AR.2 P W All gene names: ric-8; Y69A2AR.2; 4D413; CE27516; CE33952; NM_067838; RIC8_CAEEL; WBGene00004367; WP:CE27516; WP:CE33952 WormBase description: ric-8 encodes a receptor-independent G alpha guanine nucleotide exchange factor (GEF); ric-8 activity is required for regulating heterotrimeric G protein signaling pathways that control asymmetric cell division in the embryo as well as synaptic transmission in the nervous system; in the 1-cell embryo, RIC-8 functions as a GEF for GOA-1 thereby regulating spindle morphology, position, and consequently, the first asymmetric cell division; in the nervous system, ric-8 interacts with the goa-1/egl-30 pathways to regulate neurotransmitter secretion and effect normal egg laying, movement, and body flexion; in vitro, RIC-8 preferentially binds GOA-1-GDP and increases the rate of GOA-1 GTP binding; in the early embryo, RIC-8 localizes to the cellular cortex, junctions between cells, asters of the mitotic spindle, the central spindle (kinetochore microtubules), the nuclear envelope, and chromatin; RIC-8's localization to the cortex and asters mirrors that of GOA-1, while localization to the cortex and central spindle is similar to that of the GOA-1 regulators GPR-1/2, whose subcellular localization is RIC-8-dependent; in later stage animals, RIC-8 is seen in head and tail ganglia, amphid processes, and the ventral nerve cord, as well as in larval nonneuronal cells, such as germline nuclei, where it localizes near the nuclear membrane.