Kunitomo et al 2005, S2 intestine neuron-expressed, 49 genes

Gene list file name:Kunitomo2005_S2_64_intestine
Type of gene identifier:Cosmid name
Description:Kunitomo et al 2005 Supplementary 2: 64 intestine neuron-expressed genes  
Organism:Caenorhabditis elegans (nematode)
Gene list type:Experimental

Gene name             Source Gene ID          Annotation                                                  Date       Added by    

B0213.4 B0213.4 P W All gene names: nlp-29; B0213.4; 5E461; CE16775; NLP29_CAEEL; NM_071708; WBGene00003767; WP:CE16775
B0261.2 B0261.2 P W All gene names: CE-TOR; let-363; B0261.2; 1F831; CE32559; CE32560; CeTor; NM_059148; NM_059151; TOR_CAEEL; WBGene00002583; WP:CE32559; WP:CE32560 WormBase description: let-363 encodes, by alternative splicing, two large (>2600-residue) proteins with C-terminal similarity to phosphatidylinositol kinase (PIK); LET-363 proteins are orthologous to S. cerevisiae Tor1p and Tor2p and human FRAP1 (OMIM:601231, mammalian target of FKBP12-rapamycin); LET-363 proteins are required for progression through the L3 stage of larval development and are thought to generally stimulate translation of most or all mRNAs ('global translation'); LET-363 activity is also necessary for normal development and physiology of the intestine; LET-363 proteins are expressed ubiquitously, including a maternal contribution to the early embryo.
B0280.1 B0280.1 P W All gene names: B0280.1; 3I225; CE00735; CE24762; PFTB_CAEEL; WBGene00015099; WP:CE00735; WP:CE24762 WormBase description: prenyltransferase BET2
B0395.1 B0395.1 P W All gene names: nhx-1; B0395.1; CE30842; NM_078221; WBGene00003729; WP:CE30842; XQ635 WormBase description: nhx-1 encodes a sodium/proton exchanger expressed intracellularly within hypodermal and muscle cells; NHX-1 is required for embryonic viability, and is thought to prevent intracellular acidification by catalysing the electroneutral exchange of vesicular sodium for an intracellular proton. WormBase CDS description: Sodium/Proton antiporter
B0414.2 B0414.2 P W All gene names: mab-2; rnt-1; run-1; B0414.2; 1G363; CE24772; NM_059278; WBGene00004393; WP:CE24772; run WormBase description: rnt-1 encodes a transcription factor that is the sole C. elegans member of the RUNX family of transcriptional regulators; rnt-1 activity is required for several developmental processes, including regulation of hypodermal seam cell proliferation and proper development of the male tail; RNT-1 can physically interact with SMA-4 and regulates, either directly or indirectly, expression of tlp-1 and cki-1, which encode a C2H2 zinc finger and CDK inhibitor, respectively; RNT-1::GFP reporter fusions are reportedly expressed in the nuclei of hypodermal seam cells, intestinal cells, body wall muscles, and, in males, cells derived from the V5, V6 and T lineages that give rise to the sensory rays.
C08B11.4 C08B11.4 P W All gene names: nrf-6; C08B11.4; 2I320; CE27798; NM_063279; NRF6_CAEEL; WBGene00003813; WP:CE27798 WormBase description: nrf-6 encodes a protein with 12 predicted transmembrane domains that is highly similar to NDG-4 and affects embryonic viability, yolk transport, locomotion, body morphology, and affects sensitivity to fluoxetine with respect to nose-contraction response in a common pathway with ndg-4 and nrf-5; expressed in the most anterior cells of the hypodermis and in the intestine and is required in the intestine for fluoxetine-induced nose contraction and yolk transport
C10H11.1 C10H11.1 P W All gene names: C10H11.1; 1F327; CE29081; WBGene00015691; WP:CE29081
C11G6.4 C11G6.4 P W All gene names: nhr-28; C11G6.4; C11G6.4a.1; C11G6.4a.2; C11G6.4b.1; C11G6.4b.2; C11G6.4b.3; CE27061; CE37954; NHR28_CAEEL; WBGene00003624; WP:CE27061; WP:CE37954; XQ973 WormBase description: nuclear hormone receptor, nhr-28
C25A11.4 C25A11.4 P W All gene names: ajm-1; jam-1; C25A11.4; CE27083; CE27084; CE27085; CE30874; CE39677; NM_077135; NM_077136; NM_077137; NM_171966; WBGene00000100; WP:CE27083; WP:CE27084; WP:CE27085; WP:CE30874; WP:CE39677; XJ731 WormBase description: ajm-1 encodes a member of the apical junction molecule class that is required for correct elongation of the C. elegans embryo; AJM-1 contains a coiled-coil motif; AJM-1 binds DLG-1 in vitro, in yeast two-hybrid assays, and in vivo; AJM-1 is mislocalized in a dlg-1(RNAi) background; LET-413 is required for rapid confinement of DLG-1 and AJM-1 to a narrow apical region in C. elegans epithelia; CLC-1 colocalizes with AJM-1; vab-9 mutations enhance the adhesion defects of ajm-1 mutants; ajm-1 is expressed at the apical borders of all epithelia.
C29E4.3 C29E4.3 P W All gene names: ran-2; C29E4.3; 3J25; CE30621; CE37483; NM_171198; NM_171884; RGP2_CAEEL; WBGene00004303; WP:CE30621; WP:CE37483 WormBase description: ran-2 encodes the C. elegans RanGAP (GTPase activating protein) homolog, conserved amongst yeast, Drosophila (segregation distorter), Xenopus, and humans; by homology, RAN-2 is predicted to function as a key regulator of the Ran GTP/GDP cycle by stimulating the otherwise weak Ran GTPase activity; in C. elegans, RAN-2 activity is essential during early embryogenesis for comigration of centrosomes with the male pronucleus, mitotic spindle formation, chromosome segregation, and nuclear envelope assembly; in addition, RAN-2 is also required for nucleocytoplasmic transport; ran-2 reporter gene expression is detected in embryos and larvae, although the precise subcellular localization is not yet known.
C33D3.1 C33D3.1 P W All gene names: elt-2; C33D3.1; CE31430; ELT2_CAEEL; GATA; NM_077354; WBGene00001250; WP:CE31430; XL101 WormBase description: elt-2 encodes a GATA-type transcription factor most similar to the vertebrate GATA4-6 transcription factors required for cardiac and endoderm development (OMIM:601656, 600576); in C. elegans, ELT-2 is required redundantly with ELT-7 for initiating and maintaining terminal differentiation of the intestine; ELT-2 is expressed solely in the intestine, beginning embryonically at the 2E-cell stage and continuing in all intestinal cells throughout the life of the animal; in the regulatory hierarchy controlling endoderm development, ELT-2 lies downstream of the maternal regulators SKN-1 and POP-1 and the embryonic GATA factors MED-1/-2, and END-1/-3; in turn, ELT-2, along with ELT-7, likely regulates transcription of a number of intestine-specific terminal differentiation genes such as ges-1, ifb-2, pha-4, and the stress-induced mtl-2; ELT-2 also positively autoregulates, presumably to ensure maintenance of intestinal differentiation WormBase CDS description: zinc finger protein (GATA type)
C46H11.4 C46H11.4 P W All gene names: lfe-2; C46H11.4; 1F607; CE27862; CE27863; CE27864; WBGene00002979; WP:CE27862; WP:CE27863; WP:CE27864 WormBase description: lfe-2 encodes an inositol (1,4,5) triphosphate-3-kinase (IP3K); lfe-2 activity is required for normal levels of hermaphrodite fertility and for tissue-specific negative regulation of the LET-23 signaling pathway that controls spermathecal dilation and ovulation; in vitro, LFE-2 can exhibit catalytic activity, converting IP3 to IP4; an lfe-2::GFP transcriptional fusion is expressed in the adult spermatheca and in the pharynx and gut throughout larval and adult stages; misexpression of LFE-2 in gravid adults via heat shock results in ovulation defects, consistent with a role for LFE-2 in regulating this process.
C52D10.9 C52D10.9 P W All gene names: skr-8; C52D10.9; C52D10.9.1; C52D10.9.2; 4S108; CE17593; NM_070643; WBGene00004814; WP:CE17593 WormBase description: skr-8 encodes a homolog of Skp1 in S. cerevisiae, a component of the SCF (Skp1, Cullin, F-box) ubiquitin-ligase complex that regulates ubiquitin-mediated protein degradation; SKR-8 is required for is required for posterior body morphogenesis, embryonic and larval development, and cell proliferation; SKR-8 can interact with CUL-1, a C. elegans cullin homolog. WormBase CDS description: cyclin A-associated protein
C52E4.1 C52E4.1 P W All gene names: cpr-1; gcp-1; C52E4.1; 5M457; CE31896; CPR1_CAEEL; CPROT/1; NM_073601; WBGene00000781; WP:CE31896 WormBase description: cpr-1 encodes a cysteine protease of the cathepsin B-like cysteine protease family; cpr-1 appears to be required for embryogenesis; cpr-1 is specifically expressed in the gut of all stages except the embryo and around developing embryos in the gonad; expression of cpr-1 is regulated by three promoter GATA motifs. WormBase CDS description: cathepsin-like cysteine protease
C56G2.6 C56G2.6 P W All gene names: dhs-10; let-767; C56G2.6; C56G2.6.1; C56G2.6.2; 3H428; CE30639; LE767_CAEEL; NM_065985; WBGene00002891; WP:CE30639 WormBase description: let-767 encodes a short-chain dehydrogenase, reported to be required for efficient cholesterol metabolism; LET-767 is predicted to be required for the metabolism of a sterol and to be mitochondrial.
D1009.2 D1009.2 P W All gene names: cyn-8; cyp-8; D1009.2; CE04286; CE27892; CYP8_CAEEL; NM_077105; WBGene00000884; WP:CE04286; WP:CE27892; XJ531 WormBase description: cyp-8 encodes a peptidyl-propyl cis-trans isomerase of the cyclophilin family; cyclophilins are implicated in protein folding, however the precise role of cyp-8 is not known; a CYP-8-fusion protein localises specifically to gut cell nuclei.
F22D6.12 F22D6.12 P W All gene names: gly-19; F22D6.12; F22D6.12.1; F22D6.12.2; 1H689; CE29590; NM_059614; WBGene00001644; WP:CE29590 WormBase description: gly-19 encodes a protein similar to 2/I N-acetylglucosaminyltransferase; it is probably coexpressed with gly-18 in the anal sphincter muscle. WormBase CDS description: beta-1,6-N-acetylglucosaminyltransferase
F28F8.5 F28F8.5 P W All gene names: F28F8.5; 5Q54; CE09759; WBGene00009223; WP:CE09759
F31C3.1 F31C3.1 P W All gene names: cyn-5; cyp-5; F31C3.1; F31C3.1.1; F31C3.1.2; 1P632; CE17730; CYP5_CAEEL; NM_061223; WBGene00000881; WP:CE17730 WormBase description: cyp-5 encodes a cyclophilin that is functional in vitro and is predicted to be a secreted protein that is structurally most similar to human cyclophilin B; expressed in the intestine. WormBase CDS description: cyclophillin
F31F6.6 F31F6.6 P W All gene names: indy-1; nac-1; nad-1; F31F6.6; CE34007; NAD1_CAEEL; NM_078072; WBGene00003517; WP:CE34007; XP515; cenadc1 WormBase description: nad-1 encodes a low-affinity sodium-coupled dicarboxylate transporter homologous to INDY in D. melanogaster and to mammalian NaDC1 and NaDC3; nad-1 has no obvious function in either mass or individual RNAi assays; nad-1 is expressed in the intestine, in larvae and adults WormBase CDS description: low-affinity decarboxylate transporter
F32B5.8 F32B5.8 P W All gene names: cpz-1; F32B5.8; 1D256; CE36646; NM_058622; WBGene00000788; WP:CE36646 WormBase description: cpz-1 encodes a homolog of cathepsin z-like cysteine protease cyclically expressed in hypodermal cells throughout development (along with adult gonad and pharynx) and required for normal molting; CPZ-1 protein is present in cuticle regions shortly before their degradation during ecydsis, and this expression pattern is conserved in Onchocerca volvulus; cpz-1(ok497) and cpz-1(RNAi) worms have defective molting, along with misshapen heads and tails, defective gonads, and embryonic lethality. WormBase CDS description: cysteine proteinase
F33D4.2 F33D4.2 P W All gene names: dec-4; itr-1; lfe-1; F33D4.2; F33D4.2f.1; F33D4.2f.2; 4I461; CE28017; CE28018; CE31690; CE37905; CE37906; WBGene00002173; WP:CE28017; WP:CE28018; WP:CE31690; WP:CE37905; WP:CE37906 WormBase description: itr-1 encodes a putative inositol (1,4,5) trisphosphate receptor that affects the defecation cycle and pharyngeal pumping, and also affects ovulation in a pathway downstream of LET-23; interacts with UNC-54 in vivo, and is expressed in the adult intestine, pharynx, excretory cell, germ line, and spermatheca, with limited neuronal expression.
F38A6.1 F38A6.1 P W All gene names: Ce-fkh-1; fkh-1; pha-4; F38A6.1; 5V229; CE15998; NM_075605; Q17381_CAEEL; WBGene00004013; WP:CE15998 WormBase description: Fork head domain, eukaryotic transcription factors
F38B6.4 F38B6.4 P W All gene names: F38B6.4; CE28304; WBGene00018174; WP:CE28304; XH297 WormBase description: GARS/AIRS/GART
F42G8.3 F42G8.3 P W All gene names: pmk-2; F42G8.3; 4I911; CE31695; CE34862; NM_171392; NM_171913; PMK2_CAEEL; WBGene00004056; WP:CE31695; WP:CE34862 WormBase description: The pmk-2 gene encodes a homolog of p38, a type of mitogen-activated protein kinase (MAPK) that in mammals is generally activated by diverse cellular stresses and ligands.
F42G9.2 F42G9.2 P W All gene names: cyn-6; cyp-6; F42G9.2; 3B391; CE01301; CYP6_CAEEL; NM_064856; WBGene00000882; WP:CE01301 WormBase description: cyp-6 encodes a cyclophilin most similar to human secreted cyclophilin type B isoforms that is functional when expressed in E. coli; it is expressed in the intestine.
F46A9.4 F46A9.4 P W All gene names: skr-2; F46A9.4; 1K47; CE10578; NM_060111; Q93731_CAEEL; WBGene00004808; WP:CE10578 WormBase description: skr-2 encodes a homolog of Skp1 in S. cerevisiae, a core component of the SCF (Skp1p, Cullin, F-box) ubiquitin-ligase complex that facilitates ubiquitin-mediated protein degradation; SKR-2 is required for the restraint of cell proliferation, progression through the pachytene stage of meiosis, and the formation of bivalent chromosomes at diakinesis; SKR-2::GFP is detected exclusively in the intestine. WormBase CDS description: cyclin A/CDK2-associated protein P19 like
F57C9.4 F57C9.4 P W All gene names: F57C9.4; 1F403; CE28474; CE28475; Q95R06_CAEEL; WBGene00019011; WP:CE28474; WP:CE28475
H06O01.1 H06O01.1 P W All gene names: pdi-3; H06O01.1; H06O01.1.1; H06O01.1.2; H06O01.1.3; 1H592; CE11570; CEERP57; NM_059594; WBGene00003964; WP:CE11570 WormBase description: pdi-3 encodes a protein disulfide isomerase (PDI) required for normal cuticle collagen deposition and, subliminally, for maintenance of normal body shape; PDI-3 has both PDI and calcium-dependent transglutaminase activity in vitro, crosslinking proteins through a gamma-glutamyl epsilon-lysine dual residue; PDI-3 is homologous to the human PDI ERp60, as well as a homolog in the dog heartworm Dirofilaria immitis that is required for larval molting; the joint PDI/transglutaminase activity of PDI-3 is biochemically conserved in nematodes and mammals; pdi-3 is constitutively and broadly expressed, particularly in gut and hypodermis. WormBase CDS description: protein disulphide isomerase ER-60 precursor like
H22K11.1 H22K11.1 P W All gene names: asp-3; H22K11.1; ASP3_CAEEL; CE19495; NM_076741; WBGene00000216; WP:CE19495; XH411 WormBase description: asp-3 encodes an aspartyl protease homolog that is required, in parallel with ASP-4 but downstream of CLP-1 and TRA-3, for degenerative (necrotic-like) cell death in neurons induced by mutations such as mec-4(d), deg-3(d), or gsa-1(gf). WormBase CDS description: aspartyl protease
K02D7.4 K02D7.4 P W All gene names: dsc-4; K02D7.4; K02D7.4.1; K02D7.4.2; 4B68; CE33667; NM_067502; WBGene00001099; WP:CE33667 WormBase description: dsc-4 encodes the C. elegans ortholog of the large subunit of the microsomal triglyceride transfer protein; dsc-4 affects the length of the defecation cycle and genetically interacts with clk-1 with respect to defecation cycle length, and also with respect to the clk-1- dependent adjustment of defecation cycle length to temperature; a DSC-4::GFP fusion protein is expressed in the intestine beginning during embryonic elongation and continuing on through adulthood.
K08E7.9 K08E7.9 P W All gene names: pgp-1; K08E7.9; 4N356; CE11932; MDR1_CAEEL; NM_070012; WBGene00003995; WP:CE11932; cepgpA WormBase description: pgp-1 encodes a transmembrane protein that is a member of the P-glycoprotein subclass of the ATP-binding cassette (ABC) transporter superfamily; along with PGP-3, PGP-1 is required for defense against the pathogenic Pseudomonas aeruginosa strain PA14, and may facilitate ATP-dependent efflux of the toxic phenazine compounds produced by the bacteria; PGP-1 is expressed in the apical membrane of intestinal cells and in the intestinal valve cells; loss of pgp-1 activity via large-scale RNAi screens does not result in any obvious abnormalities. WormBase CDS description: multidrug resistance protein
K09C8.1 K09C8.1 P W All gene names: nhx-7; pbo-4; K09C8.1; CE31034; NM_077429; WBGene00003943; WP:CE31034; XL575 WormBase description: pbo-4 encodes a sodium/proton exchanger (also known as nhx-7), with a potential Ca[2+]/calmodulin binding domain in its C-terminal cytosolic region that could mediate calcium signaling; PBO-4 is expressed in the basolateral membrane of posterior intestinal cells; PBO-4 is required for normal posterior body muscle contraction (pBoc) during the defecation cycle; PBO-4 is thought to prevent intracellular acidification by catalysing the electroneutral exchange of extracellular sodium for an intracellular proton; specifically, PBO-4 may enable intercellular signals from intestinal cells (by secreting protons which then might activate PBO-5 in adjacent muscle cells). WormBase CDS description: Na(+)/H(+) exchanger
K11G9.6 K11G9.6 P W All gene names: met-I; mtl-1; K11G9.6; 5H172; CE07379; MT1_CAEEL; NM_072295; WBGene00003473; WP:CE07379
R12A1.4 R12A1.4 P W All gene names: ges-1; R12A1.4; R12A1.4.1; R12A1.4.2; 5B906; CE28763; EST1_CAEEL; NM_071010; WBGene00001578; WP:CE28763; ges1 WormBase description: ges-1 encodes a gut-specific type B carboxylesterase; by homology, GES-1 hydrolyzes carboxylic ester substrates to yield an alcohol and a carboxylic anion, however, loss of GES-1 activity via mutation or RNAi does not result in any obvious abnormalities; GES-1 is expressed solely in the intestinal, or E, lineage from the 4 E-cell stage of gut development through adulthood; GES-1 contains a C-terminal endoplasmic reticulum (ER) retention sequence, KDEL, which suggests that it localizes to the ER lumen; GES-1 expression in the gut appears to be positively regulated by ELT-2, a gut-specific GATA-type transcription factor expressed throughout the C. elegans life cycle and essential for normal gut development. WormBase CDS description: carboxylesterase
T03E6.7 T03E6.7 P W All gene names: cpl-1; T03E6.7; T03E6.7.1; T03E6.7.2; 5R74; CE16333; NM_074798; O45734_CAEEL; WBGene00000776; WP:CE16333 WormBase description: cpl-1 encodes a member of the cathepsin L-like cysteine protease family required for embryonic viability and normal growth; expressed in eggshells and throughout early embryos, accumulates in intestinal cells during late embryogenesis, and expressed in the cuticle, gonad, and pharynx later in development. WormBase CDS description: cathepsin-like protease
T05B4.2 T05B4.2 P W All gene names: nhr-57; T05B4.2; 5E613; CE13195; NHR57_CAEEL; NM_071752; WBGene00003647; WP:CE13195 WormBase description: zinc finger protein
W01G7.4 W01G7.4 P W All gene names: W01G7.4; 2O353; CE21230; WBGene00012188; WP:CE21230
W03G9.4 W03G9.4 P W All gene names: app-1; W03G9.4; W03G9.4.1; W03G9.4.2; 1F534; CE14560; NM_059088; O44750_CAEEL; WBGene00000155; WP:CE14560 WormBase description: aminopeptidase
Y116A8C.33 Y116A8C.33 P W All gene names: Y116A8C.33; 4S57; CE24151; WBGene00013809; WP:CE24151
Y17G7B.5 Y17G7B.5 P W All gene names: mcm-2; Y17G7B.5; Y17G7B.5b.1; Y17G7B.5b.2; 2M292; CE19038; CE36030; WBGene00003154; WP:CE19038; WP:CE36030 WormBase description: MCM2/3/5 family
Y46C8AL.1 Y46C8AL.1 P W All gene names: clec-73; Y46C8AL.1; 4E720; CE21962; Q9N3W2_CAEEL; WBGene00021579; WP:CE21962
Y47D3B.7 Y47D3B.7 P W All gene names: hlh-20; lpd-1; sbp-1; Y47D3B.7; 3M518; CE19180; NM_067071; Q9XX00_CAEEL; WBGene00004735; WP:CE19180 WormBase description: sbp-1 encodes a basic helix-loop-helix (bHLH) transcription factor homologous to the mammalian Sterol Regulatory Element Binding Proteins (SREBPs, OMIM:184756, overexpression of nuclear form of SREBP-1c is associated with insulin resistance and features of congenital generalized lipodystrophy); in C. elegans, SBP-1 activity is required for normal lipid metabolism and wild-type levels of lipogenic enzyme expression, as well as for embryonic and larval development; sbp-1 expression is detected exclusively in the intestine, the major site of fat storage, from early embryogenesis through adulthood. WormBase CDS description: Helix-loop-helix DNA-binding domain
Y47G6A.23 Y47G6A.23 P W All gene names: lpd-3; Y47G6A.23; 1E134; CE31376; NM_058781; WBGene00003060; WP:CE31376 WormBase description: lpd-3 encodes a novel protein that is nevertheless conserved amongst humans, mice, and Drosophila; in C. elegans, LPD-3 activity is required for normal lipid metabolism, as animals that have reduced lpd-3 activity as a result of RNA-mediated gene interference (RNAi) lack lipid storage granules in the intestine and are paler and skinnier than wild-type animals; lpd-3 is expressed prominently in the intestine, the major site of fat storage.
Y75B8A.4 Y75B8A.4 P W All gene names: Y75B8A.4; Y75B8A.4.1; Y75B8A.4.2; 3N201; CE23016; WBGene00013541; WP:CE23016 WormBase description: ATPases associated with various cellular activities (AAA)
ZK353.6 ZK353.6 P W All gene names: lap-1; ZK353.6; ZK353.6.1; ZK353.6.2; 3J490; AMPL_CAEEL; CE00390; NM_066453; WBGene00002249; WP:CE00390 WormBase description: The lap-1 gene encodes a homolog of the zinc metalloprotease leucine aminopeptidase LAP that is predicted to be mitochondrial. WormBase CDS description: Leucine aminopeptidase
ZK455.1 ZK455.1 P W All gene names: aco-1; gei-22; ZK455.1; ZK455.1.1; ZK455.1.2; ACOC_CAEEL; CE03812; NM_077497; WBGene00000040; WP:CE03812; XL961 WormBase description: aco-1 encodes an aconitase that is homologous to mammalian iron regulatory protein-1 (IRP1); aco-1 activity is required for normal brood sizes and, under iron stress conditions, for normal lifespan and L4-to-adult growth rates; ACO-1 physically interacts with GEX-3; like IRP1, ACO-1 has aconitase activity and is post-translationally regulated by iron, but, unlike IRP1, it lacks RNA-binding activity; ACO-1 is predicted to be mitochondrial, and its mRNA levels appear to decrease in response to iron treatment. WormBase CDS description: iron-responsive element-binding like protein
ZK455.7 ZK455.7 P W All gene names: pgp-3; ZK455.7; CE03818; MDR3_CAEEL; NM_077500; WBGene00003997; WP:CE03818; XL973; cepgpC WormBase description: pgp-3 encodes a transmembrane protein that is a member of the P-glycoprotein subclass of the ATP-binding cassette (ABC) transporter superfamily; with PGP-1, PGP-3 is required for defense against the pathogenic Pseudomonas aeruginosa strain PA14, and may facilitate ATP-dependent efflux of the toxic phenazine compounds produced by the bacteria; PGP-3 is also required for resistance to colchicine and chloroquine; PGP-3 is expressed in the apical membranes of the excretory cell and the intestinal cells; loss of pgp-3 activity via large-scale RNAi screens does not result in any obvious abnormalities. WormBase CDS description: multidrug resistance protein 3 (p-glycoprotein C)
ZK524.3 ZK524.3 P W All gene names: lrs-2; ZK524.3; 1I34; CE35160; CE35161; WBGene00003074; WP:CE35160; WP:CE35161 WormBase description: leucyl-tRNA synthetase (mitochondrial)