Denver et al 2005, differentially expressed in MA, 662 genes Gene list file name: Denver2005_ST1_differential-genes_in_MAlines Type of gene identifier: MA primer pair (sjj) Description: Denver et al 2005 Supplement Table 1: 662 genes that differentially expressed in MA(Mutation Accumulation) lines. Organism: Caenorhabditis elegans (nematode) Gene list type: Experimental Gene name Source Gene ID All gene names WormBase description WormBase CDS description Proteome description Member of lists (Publications) Other annotations AC3.7 AC3.7 dod-15; ugt-1; AC3.7; 5K877; CE05137; NM_073270; WBGene00007072; WP:CE05137 UDP-glucuronosyltransferase AH10.1 AH10.1 AH10.1; 5O629; CE07655; WBGene00007082; WP:CE07655 4-coumarate:coenzyme A ligase B0024.1 B0024.1 col-149; B0024.1; 5K772; CE05146; NM_073245; Q17417_CAEEL; WBGene00000722; WP:CE05146 collagen B0035.4 B0035.4 tag-317; B0035.4; B0035.4.1; B0035.4.2; B0035.4.3; 4M79; 4M81; CE05162; PFD4_CAEEL; WBGene00007107; WP:CE05162 paramyosin like B0218.7 B0218.7 B0218.7; 4I930; CE06690; WBGene00015051; WP:CE06690 B0222.6 B0222.6 col-144; B0222.6; 5J640; CE30585; NM_072973; WBGene00000717; WP:CE30585 B0222.7 B0222.7 col-145; B0222.7; 5J642; CE06698; NM_072974; WBGene00000718; WP:CE06698 B0222.8 B0222.8 col-10; B0222.8; 5J644; CE06699; NM_072975; WBGene00000599; WP:CE06699 col-10 encodes a collagen protein; expressed exclusively in hypodermal cells B0228.1 B0228.1 B0228.1; 2I45; CE01742; WBGene00015059; WP:CE01742; YP71_CAEEL B0261.6 B0261.6 B0261.6; 1F824; CE29532; CE39549; WBGene00015094; WP:CE29532; WP:CE39549 C23F12.1 B0272.5 C23F12.1; CE32133; CE32134; WBGene00016006; WP:CE32133; WP:CE32134; XK45 B0273.1 B0273.1 B0273.1; 4G259; CE16787; WBGene00015097; WP:CE16787 B0310.5 B0310.5 ugt-46; B0310.5; CE03878; UGT46_CAEEL; WBGene00015141; WP:CE03878; XB146 7TM chemoreceptor, ugt family B0365.3 B0365.3 eat-6; spa-1; B0365.3; B0365.3.1; B0365.3.2; 5N608; CE07721; NM_073868; NaK/1; WBGene00001137; WP:CE07721 eat-6 encodes an ortholog of the alpha subunit of a sodium/potassium ATPase, which in turn affects Na+,K(+)-ATPase activity of membranes by affecting the level of the phosphorylated intermediate of the Na+,K(+)-ATPase; EAT-6 affects relaxation of the pharyngeal muscles, fertility (and thus affects feeding); EAT-6 also affects body length, life span, and ASE, ASI and ASJ axonal outgrowth. Na(+)/K(+) ATPase alpha subunit B0365.6 B0365.6 clec-41; B0365.6; B0365.6.1; B0365.6.2; B0365.6.3; 5N616; CE07723; WBGene00007153; WP:CE07723 C-type lectin domain B0379.2 B0379.2 B0379.2; 1K644; CE07725; WBGene00007156; WP:CE07725 B0464.2 B0464.2 B0464.2; 3K585; CE20456; WBGene00007184; WP:CE20456; YKD1_CAEEL TPR Domain B0464.3 B0464.3 nlp-36; B0464.3; B0464.3.1; B0464.3.2; 3K579; CE00017; NLP36_CAEEL; WBGene00007185; WP:CE00017 B0491.3 B0491.3 B0491.3; 2L628; CE02105; WBGene00007190; WP:CE02105 B0507.3 B0507.3 B0507.3; 5J251; CE07762; CE39664; WBGene00015220; WP:CE07762; WP:CE39664 C01B10.1 C01B10.1 drh-2; C01B10.1; 4H380; CE33024; NM_068618; WBGene00001091; WP:CE33024 C01F6.2 C01F6.2 C01F6.2; CE26968; WBGene00007222; WP:CE26968 C01G5.3 C01G5.3 C01G5.3; 4H301; CE06749; WBGene00015305; WP:CE06749 C01G6.3 C01G6.3 C01G6.3; 2J561; CE37474; WBGene00007225; WP:CE37474 C02A12.4 C02A12.4 lys-7; C02A12.4; 5D960; CE07828; NM_071571; WBGene00003096; WP:CE07828 lys-7 encodes an enzyme homologous to an antimicrobial lysozyme encoded by the LYS4 gene of the protozoan parasite Entamoeba histolytica; by homology, LYS-7 is predicted to function as an antimicrobial enzyme that hydrolyzes the 1,4-beta-linkages between N-acetyl-D-glucosamine and N-acetylmuramic acid in peptidoglycan heteropolymers of prokaryotic cell walls; in C. elegans, lys-7 expression is significantly upregulated in response to infection with the Gram-negative bacterium Serratia marcescens, indicating that LYS-7 likely plays a role in the innate immune response; constitutive expression of lys-7 mRNA is detected in the intestine and the intestinal valve cells. C02B10.6 C02B10.6 C02B10.6; 4F837; CE20481; WBGene00015331; WP:CE20481 C02E7.6 C02E7.6 C02E7.6; 5F397; CE07843; WBGene00015339; WP:CE07843 C02E7.7 C02E7.7 C02E7.7; 5F396; CE07844; WBGene00015340; WP:CE07844 C03C10.3 C03C10.3 rnr-2; C03C10.3; C03C10.3.1; C03C10.3.2; C03C10.3.3; 3F184; CE00874; NM_065420; RIR2_CAEEL; WBGene00004392; WP:CE00874 Ribonuclease-diphosphate reductase M2 C03C11.1 C03C11.1 C03C11.1; 1K591; CE07873; WBGene00007274; WP:CE07873 C03F11.3 C03F11.3 C03F11.3; CE37606; WBGene00015389; WP:CE37606; XG16; YX13_CAEEL glycoprotein C04F12.7 C04F12.7 C04F12.7; 1K272; CE19680; WBGene00007301; WP:CE19680 C04G2.4 C04G2.4 msp-36; C04G2.4; 4K861; NM_069433; WBGene00003432 msp-36 encodes a protein that belongs to a family of proteins called the Major Sperm Proteins (MSPs) that is conserved in nematodes; this family comprises of closely related, small, basic proteins that make up 15% of sperm protein; this multigene family consists of over fifty genes, including many pseudogenes; MSP is involved in both extracellular signaling and cytoskeletal functions during reproduction-MSP antagonizes Eph/ephrin signaling, in part, by binding VAB-1 Eph receptor tyrosine kinase on oocytes and sheath cells to promote oocyte maturation and MAPK activation; MSP assembles into fibrous networks that drives movement of the C. elegans sperm; msp genes are expressed only in late primary spermatocytes. major sperm protein C04G2.8 C04G2.8 C04G2.8; 4K876; CE05216; WBGene00007307; WP:CE05216 C04G2.9 C04G2.9 C04G2.9; 4K879; CE05217; WBGene00007308; WP:CE05217 C05A9.1 C05A9.1 pgp-5; C05A9.1; CE05221; NM_077409; WBGene00003999; WP:CE05221; XL474 pgp-5 encodes a transmembrane protein that is a member of the P-glycoprotein subclass of the ATP-binding cassette (ABC) transporter superfamily; by homology, PGP-5 is predicted to function as an ATP-dependent efflux pump that protects C. elegans by exporting exogenous toxins; however, as loss of pgp-5 activity via large-scale RNAi screens does not result in any obvious abnormalities, the precise role of PGP-5 in C. elegans development and/or behavior is not yet known. p-glycoprotein C05B5.2 C05B5.2 C05B5.2; 3L90; CE00878; WBGene00007320; WP:CE00878; YKO2_CAEEL C05C12.1 C05C12.1 C05C12.1; 4M19; CE02965; WBGene00007335; WP:CE02965 serine/threonine kinase C05C8.3 C05C8.3 dao-1; fkb-3; C05C8.3; 5H707; CE07921; NM_072434; WBGene00001428; WP:CE07921 fkb-3 encodes a peptidylprolyl cis/trans isomerase homologous to mammalian FK506 immunosuppressant-binding protein 9; FKB-3 expression is positively regulated by signaling through the DAF-2 insulin receptor-like pathway and the activity of the DAF-16 fork-head transcription factor suggesting that FKB-3 could play a role in metabolism and longevity; however, as loss of FKB-3 function via RNA-mediated interference (RNAi) does not result in any abnormalities, the precise role of FKB-3 in C. elegans development and/or behavior is not yet known; FKB-3 contains a predicted endoplasmic reticulum (ER) retention sequence and is thus proposed to localize to the ER. FKBP-binding protein C06A1.3 C06A1.3 C06A1.3; 2K863; CE02116; WBGene00007354; WP:CE02116; YT91_CAEEL serine/threonine protein phosphatase C06A8.6 C06A8.6 C06A8.6; 2I63; CE02457; WBGene00015516; WP:CE02457 C06B3.6 C06B3.6 C06B3.6; 5O390; CE07963; WBGene00007365; WP:CE07963 C06G1.1 C06G1.1 C06G1.1; CE27054; WBGene00015545; WP:CE27054; XR251 C06G1.2 C06G1.2 C06G1.2; CE03965; WBGene00015546; WP:CE03965; XR239 C07B5.5 C07B5.5 nuc-1; C07B5.5; CE00895; NM_077203; NUC1_CAEEL; WBGene00003828; WP:CE00895; XK159 The nuc-1 gene encodes a DNase II homolog similar to mammalian and Drosophila DNaseII enzymes and is required for DNA degradation during apoptosis as well as for degradation of dietary DNA during normal feeding; during apoptosis, NUC-1 functions in apoptotic cells at an intermediate stage of DNA degradation, after the killing step, but prior to cell-corpse engulfment. C07D8.6 C07D8.6 C07D8.6; C07D8.6.1; C07D8.6.2; CE06776; WBGene00015565; WP:CE06776; XH961 aldehyde reductase C08B11.1 C08B11.1 zyg-11; C08B11.1; 2I309; CE01471; NM_063276; WBGene00006996; WP:CE01471; ZYG11_CAEEL Leucine Rich Repeat (2 copies) C08B11.4 C08B11.4 nrf-6; C08B11.4; 2I320; CE27798; NM_063279; NRF6_CAEEL; WBGene00003813; WP:CE27798 nrf-6 encodes a protein with 12 predicted transmembrane domains that is highly similar to NDG-4 and affects embryonic viability, yolk transport, locomotion, body morphology, and affects sensitivity to fluoxetine with respect to nose-contraction response in a common pathway with ndg-4 and nrf-5; expressed in the most anterior cells of the hypodermis and in the intestine and is required in the intestine for fluoxetine-induced nose contraction and yolk transport C08B6.3 C08B6.3 C08B6.3; 5K592; CE05240; WBGene00007424; WP:CE05240 C09F12.1 C09F12.1 clc-1; C09F12.1; CE08040; NM_077446; WBGene00000522; WP:CE08040; XL667 clc-1 encodes a claudin homolog, closely similar to CLC-2, that is required for normal cohesion of apical junctions in epithelia; claudins are integral membrane proteins with four transmembrane sequences that are found in mammalian tight junctions (TJs), induce TJs when transgenically expressed in cells normally lacking them, and can mediate the specific conductance of of specific ions (e.g., magnesium or calcium) through TJs while blocking the flow of water; CLC-1 maintains the impermeability ('barrier function') of epithelia, since clc-1(RNAi) animals have abnormal permeability of the pharynx to dyes; clc-1 is expressed in spermatheca, pharynx, intestine, hypodermis, the excretory-secretory system, and the cell-cell junctions of the vulva; in pharyngeal cells, CLC-1 colocalizes with AJM-1 in long thin lines, parallel to the pharyngeal axis and lining the lumenal surface, that appear to correspond with apical intercellular junctions. C09G1.1 C09G1.1 pqn-11; C09G1.1; CE37313; NM_078217; Q17862_CAEEL; WBGene00004103; WP:CE37313; XQ582 PQN-11 encodes an unfamiliar protein with a glutamine/asparagine-rich domain that is dispensable for viability and gross morphology. C09G5.3 C09G5.3 col-79; C09G5.3; 2K993; CE01483; COL79_CAEEL; NM_063907; WBGene00000655; WP:CE01483 collagen C09G5.5 C09G5.5 col-80; C09G5.5; 2K997; CE01485; COL80_CAEEL; NM_063909; WBGene00000656; WP:CE01485 collagen C09G5.6 C09G5.6 bli-1; C09G5.6; 2L1; BLI1_CAEEL; CE35827; NM_063910; WBGene00000251; WP:CE35827 The bli-1 gene encodes an unusual cuticular collagen that is required for proper strut formation within the unique medial layer of the adult cuticle; bli-1 interacts genetically with other cuticular collagens such as bli-2 and rol-1, and may be processed for secretion by BLI-4, a Kex2/subtilisin serine endoproteinase; consistent with its role in adult cuticle formation, bli-1 mRNA is highly expressed only during the L4 larval stage. collagen C10G11.9 C10G11.9 C10G11.9; 1G850; CE08088; WBGene00015689; WP:CE08088 C10G8.4 C10G8.4 C10G8.4; 5F789; CE08075; WBGene00015683; WP:CE08075 C11E4.2 C11E4.2 C11E4.2; CE08102; GPX3_CAEEL; WBGene00007517; WP:CE08102; XK205 glutathione peroxidase C12D12.1 C12D12.1 C12D12.1; CE27679; CE29576; WBGene00015713; WP:CE27679; WP:CE29576; XE123 C12D5.7 C12D5.7 cyp-33A1; C12D5.7; 5I160; CE06809; NM_072587; WBGene00015709; WP:CE06809 cytochrome P450 C12D8.11 C12D8.11 rop-1; C12D8.11; C12D8.11.1; C12D8.11.2; 5K734; CE15613; NM_073237; RO60_CAEEL; WBGene00004405; WP:CE15613; rop1 rop-1 encodes an RNAi-binding protein that is orthologous to the vertebrate 60-kDa Ro autoantigen that is the protein component of the Ro ribonucleoprotein (RNP) complex; ROP-1 binds the single C. elegans Ro RNP RNA component, YRN-1 (Y RNA) in vivo and although loss of rop-1 activity via mutation results in no obvious visible phenotypes, it does result in a dramatic decrease in YRN-1 levels, indicating that ROP-1 is necessary for maintaining normal levels of the Ro RNP Y RNA; in addition, rop-1 mutations also result in a statistically significant increase in mutant 5S rRNA molecules found in ribosomal RNA preparations, suggesting that ROP-1 may play a role in quality control of 5S rRNA processing; rop-1 mRNA is detectable during all stages of development, and rop-1 promoter fusions appear to be expressed in all cell types, except the germline. ROP-1 ribonucleoprotein RO autoantigen C14A6.1 C14A6.1 clec-48; C14A6.1; 5S639; CE18493; WBGene00007565; WP:CE18493 Lectin C-type domain short and long forms (2 domains) C14B9.4 C14B9.4 plk-1; C14B9.4; C14B9.4a.1; C14B9.4a.2; 3J193; CE26649; CE30602; PLK1_CAEEL; WBGene00004042; WP:CE26649; WP:CE30602; plc1 plk-1 encodes a serine/threonine polo-like kinase homologous to Drosophila polo and Saccharomyces cerevisiae CDC5; PLK-1 is required for meiotic nuclear envelope breakdown, polar body formation and extrusion, and proper chromosome segregation during meiosis, and additionally, may play a role in germline development; PLK-1 is proposed to phosphorylate REC-8, a meiotic-specific cohesin, thus promoting REC-8 degradation and subsequent separation of sister chromatids; PLK-1 is localized diffusely in the cytoplasm of mature oocytes, but during meiosis I becomes associated with pre-metaphase chromatin and then at anaphase with chromatin and the area between dividing chromatin; in embryos, PLK-1 localizes to centrosomes, metaphase chromatin, and during telophase, to the area between dividing chromatin. C14C10.1 C14C10.1 C14C10.1; 5N69; CE05280; WBGene00007584; WP:CE05280 mitochondrial carrier protein C14C11.1 C14C11.1 C14C11.1; 5G145; CE06820; WBGene00015765; WP:CE06820 C14F11.4 C14F11.4 C14F11.4; CE37197; CE37198; WBGene00015780; WP:CE37197; WP:CE37198; XG850 C15C7.5 C15C7.5 C15C7.5; CE03991; WBGene00015791; WP:CE03991; XD770 C15F1.2 C15F1.H C15F1.2; 2H277; CE23545; WBGene00015795; WP:CE23545 C16B8.3 C16B8.3 C16B8.3; C16B8.3.1; C16B8.3.2; CE04013; Q18043_CAEEL; WBGene00015823; WP:CE04013; XE586 C16H3.2 C16H3.2 lec-9; C16H3.2; CE08236; NM_078443; WBGene00002272; WP:CE08236; XS215 lec-9 encodes a predicted lectin that affects embryonic viability. sugar-binding protein C17E7.9 C17E7.9 C17E7.9; 5E368; CE27700; CE27701; WBGene00015903; WP:CE27700; WP:CE27701 C17F4.5 C17F4.5 C17F4.5; 2D538; CE27075; WBGene00015912; WP:CE27075 This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins. C17H12.3 C17H12.3 C17H12.3; 4H558; CE16864; WBGene00015929; WP:CE16864 protein-tyrosine phosphatase C17H12.8 C17H12.8 C17H12.8; 4H583; CE19360; WBGene00015933; WP:CE19360 C18E9.1 C18E9.1 cal-2; C18E9.1; 2J251; CE34702; NM_063505; WBGene00000286; WP:CE34702 cal-2 encodes a calmodulin homolog required for embryonic development or viability; CAL-2 is closely similar to its paralogs CAL-1, CAL-3, CAL-4 and CMD-1. calmodulin C18E9.9 C18E9.9 C18E9.9; 2J278; CE05301; Q18089_CAEEL; WBGene00007689; WP:CE05301 C18G1.9 C18G1.9 C18G1.9; 5F242; CE17425; WBGene00015987; WP:CE17425 C18H7.4 C18H7.4 C18H7.4; 4B347; CE17429; WBGene00015994; WP:CE17429 protein kinase C24D10.2 C24D10.2 C24D10.2; 4F929; CE16875; WBGene00016054; WP:CE16875 C24D10.7 C24D10.7 C24D10.7; 4F928; CE16879; WBGene00016058; WP:CE16879 C25A11.4 C25A11.4 ajm-1; jam-1; C25A11.4; CE27083; CE27084; CE27085; CE30874; CE39677; NM_077135; NM_077136; NM_077137; NM_171966; WBGene00000100; WP:CE27083; WP:CE27084; WP:CE27085; WP:CE30874; WP:CE39677; XJ731 ajm-1 encodes a member of the apical junction molecule class that is required for correct elongation of the C. elegans embryo; AJM-1 contains a coiled-coil motif; AJM-1 binds DLG-1 in vitro, in yeast two-hybrid assays, and in vivo; AJM-1 is mislocalized in a dlg-1(RNAi) background; LET-413 is required for rapid confinement of DLG-1 and AJM-1 to a narrow apical region in C. elegans epithelia; CLC-1 colocalizes with AJM-1; vab-9 mutations enhance the adhesion defects of ajm-1 mutants; ajm-1 is expressed at the apical borders of all epithelia. C25D7.1 C25D7.1 C25D7.1; 5P516; CE08387; WBGene00007714; WP:CE08387 C25D7.2 C25D7.2 C25D7.2; 5P518; CE08388; WBGene00007715; WP:CE08388 C25G4.6 C25G4.6 C25G4.6; 4N221; CE05307; WBGene00007733; WP:CE05307 PDZ domain (Also known as DHR or GLGF). (2 domains) C26B9.3 C26B9.3 C26B9.3; CE29187; WBGene00016133; WP:CE29187; XF957 C26B9.5 C26B9.5 C26B9.5; CE04098; WBGene00016134; WP:CE04098; XF949 lysosomal Pro-X carboxypeptidase C26F1.1 C26F1.1 C26F1.1; 5I267; CE32807; CE35249; WBGene00016146; WP:CE32807; WP:CE35249 C27D6.3 C27D6.3 C27D6.3; 2F464; CE01813; WBGene00016161; WP:CE01813; YQ93_CAEEL MST101-2 protein (Fruit Fly) C27D8.1 C27D8.1 C27D8.1; 4N483; CE18539; WBGene00007777; WP:CE18539 serine/threonine kinase C27D8.2 C27D8.2 C27D8.2; 4N479; CE08421; WBGene00007778; WP:CE08421 C28A5.6 C28A5.6 C28A5.6; 3F514; CE00673; WBGene00007791; WP:CE00673 serine/threonine kinase C28C12.7 C28C12.6, C28C12.7 spp-10; C28C12.7; C28C12.7a.1; C28C12.7a.2; 4J243; CE29486; CE31323; NM_171399; NM_171400; WBGene00004995; WP:CE29486; WP:CE31323 spp-10 encodes two protein isoforms that are orthologous to the human gene PROSAPOSIN (PSAP; OMIM:176801, mutated in Gaucher disease and metachromatic leukodystrophy); SPP-10A and -10B are predicted to have 3 and 4 embedded saposin sequences, that are likely to be split into individual saposin peptides by proteolysis; in mammals, saposins activate the enzymes sphingomyelinphosphodiesterase and beta-glucosylceramidase; spp-10 has no obvious function in mass RNAi assays. 7TM chemoreceptor, spp family C28C12.7 C28C12.6, C28C12.7 spp-10; C28C12.7; C28C12.7a.1; C28C12.7a.2; 4J243; CE29486; CE31323; NM_171399; NM_171400; WBGene00004995; WP:CE29486; WP:CE31323 spp-10 encodes two protein isoforms that are orthologous to the human gene PROSAPOSIN (PSAP; OMIM:176801, mutated in Gaucher disease and metachromatic leukodystrophy); SPP-10A and -10B are predicted to have 3 and 4 embedded saposin sequences, that are likely to be split into individual saposin peptides by proteolysis; in mammals, saposins activate the enzymes sphingomyelinphosphodiesterase and beta-glucosylceramidase; spp-10 has no obvious function in mass RNAi assays. 7TM chemoreceptor, spp family C28D4.7 C28D4.4 C28D4.7; 4K506; CE25789; WBGene00007794; WP:CE25789 C28D4.8 C28D4.5 C28D4.8; 4K512; CE25790; WBGene00007795; WP:CE25790 C29E4.1 C29E4.1 col-90; C29E4.1; 3J39; CE00083; COL90_CAEEL; NM_066328; WBGene00000665; WP:CE00083 Cuticle collagen C29E4.4 C29E4.4 npp-15; C29E4.4; 3J21; CE37484; CeNup133; NM_066323; NU133_CAEEL; WBGene00003801; WP:CE37484 C29E6.3 C29E6.3 pph-2; pph2A-c; C29E6.3; 4M640; CE17478; NM_069850; WBGene00004084; WP:CE17478 protein tyrosine phosphatase C29F4.1 C29F4.1 col-125; C29F4.1; C29F4.1.1; C29F4.1.2; 4L991; CE03038; NM_069706; WBGene00000699; WP:CE03038 collagen C29F9.2 C29F9.2 C29F9.2; 3A339; 3A749; CE08450; WBGene00016217; WP:CE08450 C30B5.4 C30B5.4 C30B5.4; 2G486; CE02523; Q18318_CAEEL; WBGene00016245; WP:CE02523 Probable RNA binding protein C30H6.5 C30H6.5 C30H6.5; 4S317; CE15649; WBGene00007823; WP:CE15649 C31C9.1 C31C9.1 tag-10; C31C9.1; 2N925; CE32597; CE32598; WBGene00006404; WP:CE32597; WP:CE32598 tag-10 encodes, by alternative splicing, two nearly identical proteins; TAG-10 proteins are putatively secreted, with an N-terminal signal sequence and four C-terminal WD40 repeats; TAG-10 proteins are orthologous to the GA1 apical gut membrane polyprotein of Haemonchus contortus, and more distantly similar to the periplasmic TolB colicin receptor subunit of E. coli. C31H5.6 C31H5.6 C31H5.6; 1J620; CE17486; WBGene00007857; WP:CE17486 C32E12.1 C32E12.1 C32E12.1; 1F803; CE04133; WBGene00016327; WP:CE04133 C32E8.4 C32E8.4 C32E8.4; 1E353; CE29692; WBGene00016322; WP:CE29692 C32F10.5 C32F10.5 hmg-3; C32F10.5; 1G392; CE08542; NM_059287; SSP1B_CAEEL; WBGene00001973; WP:CE08542 single-strand recognition protein C33A12.6 C33A12.6 ugt-21; C33A12.6; 4K263; CE05352; WBGene00007885; WP:CE05352 UDP-glucuronysltransferase C33F10.12 C33F10.12 C33F10.12; 2F126; CE04144; WBGene00016358; WP:CE04144 mitochondrial phosphate carrier protei C33G8.1 C33G8.1 srw-127; C33G8.1; 5H495; CE34730; NM_072375; WBGene00005874; WP:CE34730 7TM chemoreceptor, srw family C33H5.13 C33H5.13 C33H5.13; 4I556; CE04156; WBGene00016379; WP:CE04156 C34D1.5 C34D1.5 C34D1.5; 5N749; CE18541; WBGene00007932; WP:CE18541 Basic region plus leucine zipper transcription factors C34D4.9 C34D4.9 nas-8; C34D4.9; 4H881; CE31327; NAS8_CAEEL; NM_068713; WBGene00003527; WP:CE31327 C34F11.4 C34F11.4 msp-50; C34F11.4; 2F491; NM_062571; WBGene00003443 msp-50 encodes a protein that belongs to a family of proteins called the Major Sperm Proteins (MSPs) that is conserved in nematodes; this family consists of closely related, small, basic proteins that make up 15% of sperm protein; this multigene family consists of over fifty genes, including many pseudogenes; MSPs are involved in both extracellular signaling and cytoskeletal functions during reproduction-MSP antagonizes Eph/ephrin signaling, in part, by binding VAB-1 Eph receptor tyrosine kinase on oocytes and sheath cells to promote oocyte maturation and MAPK activation; MSPs assemble into fibrous networks that drive movement of the C. elegans sperm; msp genes are expressed only in late primary spermatocytes. major sperm protein C34F11.6 C34F11.6 msp-49; C34F11.6; 2F485; CE04166; MSP49_CAEEL; NM_062569; WBGene00003442; WP:CE04166 msp-49 encodes a protein that belongs to a family of proteins called the Major Sperm Proteins (MSPs) that is conserved in nematodes; this family consists of closely related, small, basic proteins that make up 15% of sperm protein; this multigene family consists of over fifty genes, including many pseudogenes; MSPs are involved in both extracellular signaling and cytoskeletal functions during reproduction-MSP antagonizes Eph/ephrin signaling, in part, by binding VAB-1 Eph receptor tyrosine kinase on oocytes and sheath cells to promote oocyte maturation and MAPK activation; MSPs assemble into fibrous networks that drive movement of the C. elegans sperm; msp genes are expressed only in late primary spermatocytes. major sperm protein C34H4.1 C34H4.1 C34H4.1; 4C321; CE25804; WBGene00016424; WP:CE25804 C35A5.8 C35A5.8 C35A5.8; 5L4; CE15680; WBGene00007952; WP:CE15680 C35B1.5 C35B1.5 C35B1.5; C35B1.5.1; C35B1.5.2; C35B1.5.3; 4E848; CE16903; WBGene00016435; WP:CE16903 C35D10.2 C35D10.2 C35D10.2; 3F961; CE01196; Q18488_CAEEL; WBGene00016440; WP:CE01196 C36A4.2 C36A4.2 cyp-25A2; C36A4.2; 3E925; CE37617; NM_065375; WBGene00007964; WP:CE37617 cytochrome P450 C36F7.5 C36F7.5 C36F7.5; 1K150; CE08609; WBGene00007986; WP:CE08609 E02D9.1 C37A2.1 C37A2.1; E02D9.1; E02D9.1b.1; E02D9.1b.2; 1H379; CE08610; CE27902; CE31335; CE31336; WBGene00017098; WP:CE08610; WP:CE27902; WP:CE31335; WP:CE31336 protein kinase C37A2.3 C37A2.3 C37A2.3; 1H361; CE08612; WBGene00016491; WP:CE08612 acyl-CoA dehydrogenase C38C3.3 C38C3.3 C38C3.3; 5B975; CE29711; WBGene00016512; WP:CE29711 C38C6.6 C38C6.6 tag-297; C38C6.6; C38C6.6.1; C38C6.6.2; 2O915; CE15698; WBGene00007999; WP:CE15698 C39H7.1 C39H7.1 C39H7.1; 4G397; CE06942; WBGene00016541; WP:CE06942 casein kinase C40H5.1 C40H5.1 nspa-9; C40H5.1; CE08649; WBGene00043187; WP:CE08649 C41G7.6 C41G7.6 C41G7.6; 1K102; CE17540; WBGene00008063; WP:CE17540 C43E11.5 C43E11.5 C43E11.5; 1E807; CE08683; WBGene00016605; WP:CE08683 C43E11.6 C43E11.6 nab-1; C43E11.6; C43E11.6d.1; C43E11.6d.2; C43E11.6d.3; C43E11.6e.1; C43E11.6e.2; 1E803; CE08684; CE27846; CE27847; CE29717; CE37753; NM_058931; NM_058932; NM_058933; NM_171836; WBGene00003516; WP:CE08684; WP:CE27846; WP:CE27847; WP:CE29717; WP:CE37753 nab-1 encodes a PDZ and SAM domain-containing protein that is the sole C. elegans ortholog of the mammalian Neurabin/Spinophilin proteins; by homology, NAB-1 is predicted to interact with F-actin, ZYG-8/Doublecortin and the SAD-1 serine/threonine kinase to regulate interactions between the actin and microtubule networks during cell migration, growth cone guidance, and cell division; loss of nab-1 activity via RNAi has been reported to result in early embryonic lethality, dumpy and left-handed roller animals, as well as abnormalities in germ-line development and vulval morphogenesis; in large-scale screens, nab-1 RNAi did not result in any obvious abnormalities; NAB-1 translational reporter fusions show expression in hypodermal cells, neurons, and muscle. C43F9.6 C43F9.6 C43F9.6; 4L357; CE19734; WBGene00008074; WP:CE19734 Sodium and potassium ATPases C43G2.3 C43G2.3 C43G2.3; 4H343; CE36277; WBGene00016612; WP:CE36277 C44B7.8 C44B7.8 pmp-1; C44B7.8; 2H172; CE02546; NM_063006; WBGene00004058; WP:CE02546 ATP-binding protein C44C8.4 C44C8.4 C44C8.4; 4B645; CE17543; WBGene00016649; WP:CE17543 This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins. C44E4.3 C44E4.3 C44E4.3; 1F206; CE34271; WBGene00016652; WP:CE34271 aminotransferase C45G9.4 C45G9.4 C45G9.4; 3G153; CE01855; WBGene00016675; WP:CE01855; YQI4_CAEEL C45G9.9 C45G9.9 C45G9.9; 3G144; CE01860; WBGene00016680; WP:CE01860; YQI9_CAEEL C47A4.3 C47A4.3 C47A4.3; 4O506; CE19739; WBGene00008124; WP:CE19739 Ser/Thr protein phosphatase C47B2.6 C47B2.6 C47B2.6; 1N569; CE17566; CE38295; O62107_CAEEL; WBGene00008132; WP:CE17566; WP:CE38295 The C47B2.6 gene encodes an ortholog of the human gene UDP-GALACTOSE-4-EPIMERASE (GALE; OMIM:606953), which when mutated leads to galactose epimerase deficiency (OMIM:230350). NAD dependant epimerase/dehydratase family C47C12.5 C47C12.5 C47C12.5; WBGene00043195 C47E12.11 C47E12.11 C47E12.11; 4K735; CE05455; WBGene00008154; WP:CE05455 C47E8.5 C47E8.5 daf-21; tax-3; C47E8.5; C47E8.5.1; C47E8.5.2; C47E8.5.3; 5P167; CE05441; HSP90_CAEEL; NM_074225; WBGene00000915; WP:CE05441 daf-21 encodes a member of the Hsp90 family of molecular chaperones; DAF-21 activity is required for larval development, negative regulation of dauer larva formation, and a number of specific chemosensory behaviors, such as the response to chemicals and odorants detected by the ASE and AWC sensory neurons; a daf-21 sensory defect can be rescued by a cyclic GMP analogue, suggesting that, in regulating chemosensory behaviors, DAF-21 acts at a similar point as the DAF-11 guanylyl cyclase; down-regulation of daf-21 via RNAi results in a small but reproducible reduction in age-1 life span, suggesting that daf-21 is part of a chaperone network required for the extended life span seen in age-1 mutant animals. heat shock protein (HSP90) C48E7.7 C48E7.7 C48E7.7; 1G811; CE08822; WBGene00016752; WP:CE08822 C50B6.4 C50B6.4 col-161; C50B6.4; 5N796; CE08873; NM_073899; WBGene00000734; WP:CE08873 collagen C52D10.13 C52D10.13 col-138; C52D10.13; 4S124; CE17596; NM_070647; WBGene00000711; WP:CE17596 cuticular collagen C52E4.1 C52E4.1 cpr-1; gcp-1; C52E4.1; 5M457; CE31896; CPR1_CAEEL; CPROT/1; NM_073601; WBGene00000781; WP:CE31896 cpr-1 encodes a cysteine protease of the cathepsin B-like cysteine protease family; cpr-1 appears to be required for embryogenesis; cpr-1 is specifically expressed in the gut of all stages except the embryo and around developing embryos in the gonad; expression of cpr-1 is regulated by three promoter GATA motifs. cathepsin-like cysteine protease C52E4.7 C52E4.7 C52E4.7; 5M475; CE08949; WBGene00008259; WP:CE08949 C54D10.7 C54D10.7 C54D10.7; 5M916; CE05503; WBGene00008301; WP:CE05503 C54D2.1 C54D2.1 C54D2.1; CE02558; WBGene00016915; WP:CE02558; XI463 C54G4.3 C54G4.3 C54G4.3; 1I580; CE05509; WBGene00008313; WP:CE05509 C55B7.1 C55B7.1 glh-2; C55B7.1; 1H93; CE09012; GLH2_CAEEL; NM_059475; WBGene00001599; WP:CE09012 glh-2 encodes a putative DEAD-box RNA helicase that contains six CCHC zinc fingers and is homologous to Drosophila VASA, a germ-line-specific, ATP-dependent, RNA helicase; at non-permissive temperatures, GLH-2 plays a role in germ-line development and fertility, specifically in regulating the normal extent of germ-line proliferation, oogenesis, and the production of functional sperm; GLH-2 activity may also be required for the wild-type morphology of P granules and for localization of several protein components, but not accumulation of P granule mRNA components; GLH-2 interacts in vitro with itself and with KGB-1, a JNK-like MAP kinase; GLH-2 is a constitutive P granule component and thus, with the exception of mature sperm, is expressed in germ cells at all stages of development; GLH-2 is cytoplasmic in oocytes and the early embryo, while perinuclear in all later developmental stages as well as in the distal and medial regions of the hermaphrodite gonad; GLH-2 is expressed at barely detectable levels in males. RNA helicase C55B7.10 C55B7.10 C55B7.10; 1H78; CE32839; WBGene00016946; WP:CE32839 casein kinase C55C3.4 C55C3.4 C55C3.4; 4G442; CE06991; WBGene00016954; WP:CE06991 tyrosine-protein kinase MTCE.31 COII MTCE.31; CE35351; COX2; COX2_CAEEL; MTCE31; WBGene00010965; WP:CE35351 cytochrome oxidase subunit II D1014.5 D1014.5 D1014.5; 5I605; CE07007; WBGene00017018; WP:CE07007 D1037.3 D1037.3 ftn-2; D1037.3; D1037.3.1; D1037.3.2; 1E248; CE20622; NM_058797; Q9TYS3_CAEEL; WBGene00001501; WP:CE20622 ftn-2 encodes one of two C. elegans ferritin heavy chain homologs; loss of ftn-2 activity via deletion mutation results in slightly lower brood sizes and, under iron stress conditions, slightly faster growth from the L4 to adult stage of development, and slightly reduced lifespan; an ftn-2::gfp reporter fusion is expressed in diverse tissues, including the pharynx, intestine, and hypodermis, and its expression, along with that of ftn-2 mRNA, does not appear to change significantly under iron stress conditions. ferritin D1081.4 D1081.4 D1081.4; 1J44; CE28544; WBGene00008382; WP:CE28544 guanine nucleotide binding domains D2023.2 D2023.2 pyc-1; D2023.2; D2023.2.1; D2023.2.2; D2023.2.3; 5M298; CE09072; NM_073576; PYC1_CAEEL; WBGene00004258; WP:CE09072 pyc-1 encodes the C. elegans pyruvate carboxylase ortholog (OMIM:266150, deficiencies in humans are associated with lactic acidemia, neurological abnormalities, and early death); by homology, PYC-1 is predicted to function as a key regulatory enzyme of gluconeogenesis, lipogenesis, and anaplerosis, localizing to the mitochondrial matrix and catalyzing the formation of oxaloacetate from pyruvate and carbonate; however, loss of pyc-1 activity via large-scale RNAi screens does not result in any obvious abnormalities; pyc-1 expression is induced upon exposure of C. elegans to cadmium. pyruvate carboxylase D2023.5 D2023.5 D2023.5; 5M306; CE09075; THT2_CAEEL; WBGene00008409; WP:CE09075 thiosulphate sulphurtransferase D2030.9 D2030.9 D2030.9; D2030.9a.1; D2030.9a.2; 1I177; CE09086; CE23620; WBGene00008419; WP:CE09086; WP:CE23620; YRIQ_CAEEL Lithosperm lec14B protein like E01A2.4 E01A2.F E01A2.4; 1E698; CE24871; WBGene00017086; WP:CE24871 E01G4.6 E01G4.6 E01G4.6; 2N775; CE15755; WBGene00008448; WP:CE15755 E03H12.5 E03H12.5 E03H12.5; 4F743; CE09144; WBGene00017112; WP:CE09144 F01F1.6 F01F1.6 alh-9; F01F1.6; F01F1.6.1; F01F1.6.2; F01F1.6.3; 3G947; AL7A1_CAEEL; CE39486; NM_065862; WBGene00000115; WP:CE39486 Aldehyde dehydrogenase F02A9.2 F02A9.2 far-1; F02A9.2; F02A9.2.1; F02A9.2.2; F02A9.2.3; 3K170; CE00133; FAR1_CAEEL; NM_066609; WBGene00001385; WP:CE00133 far-1 encodes a fatty acid/retinol binding protein; expressed throughout development with highest expression levels in L3 stage larvae and in adult males. O. volvulus 20Kd antigenic peptide F02E9.5 F02E9.5 F02E9.5; 1J2; CE23628; WBGene00008530; WP:CE23628 F07A5.2 F07A5.2 F07A5.2; 1H929; CE05555; WBGene00008541; WP:CE05555 F08B1.1 F08B1.1 nrf-2; vhp-1; F08B1.1; F08B1.1a.1; F08B1.1a.2; F08B1.1a.3; F08B1.1c.1; F08B1.1c.2; F08B1.1c.3; 2F629; CE27918; CE27919; CE32357; NM_062596; NM_062597; NM_182126; VHP1_CAEEL; WBGene00006923; WP:CE27918; WP:CE27919; WP:CE32357 protein tyrosine phosphatase F08B12.4 F08B12.4 F08B12.4; F08B12.4.1; F08B12.4.2; CE26708; WBGene00008572; WP:CE26708; XM26; YZ10_CAEEL F08F3.4 F08F3.4 F08F3.4; 5F889; CE32856; WBGene00017262; WP:CE32856 C25A6.1 F08F3.5 C25A6.1; C25A6.B; 5F887; CE38785; NM_072031; WBGene00016081; WP:CE38785 F08F3.6 F08F3.6 F08F3.6; 5F896; CE09261; WBGene00017263; WP:CE09261 This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins. F08G2.1 F08G2.1 his-44; F08G2.1; 2O118; H2B1_CAEEL; NM_064496; WBGene00001918; his 11 his-44 encodes an H2B histone. Core histones H2A, H2B, H3 and H4 F09B12.1 F09B12.1 mlt-9; F09B12.1; F09B12.1b.1; F09B12.1b.2; CE23633; CE23634; WBGene00008605; WP:CE23633; WP:CE23634; XP722 F09B9.1 F09B9.1 F09B9.1; CE15758; WBGene00008602; WP:CE15758; XK758 F09C12.8 F09C12.2 F09C12.8; 2F403; CE32360; WBGene00017279; WP:CE32360 F09C12.7 F09C12.7 msp-74; msp-74ps; F09C12.7; 2F404; CE02603; NM_062548; WBGene00003462; WP:CE02603 msp-74 encodes a protein that belongs to a family of proteins called the Major Sperm Proteins (MSPs) that is conserved in nematodes; this family consists of closely related, small, basic proteins that make up 15% of sperm protein; this multigene family consists of over fifty genes, including many pseudogenes; MSPs are involved in both extracellular signaling and cytoskeletal functions during reproduction-MSP antagonizes Eph/ephrin signaling, in part, by binding VAB-1 Eph receptor tyrosine kinase on oocytes and sheath cells to promote oocyte maturation and MAPK activation; MSPs assemble into fibrous networks that drive movement of the C. elegans sperm; msp genes are expressed only in late primary spermatocytes. F09E8.6 F09E8.6 nas-14; F09E8.6; 4N935; CE35854; NAS14_CAEEL; NM_070132; WBGene00003533; WP:CE35854 zinc metalloprotease F09F7.5 F09F7.5 F09F7.5; 3G639; CE01237; CE29259; CE29260; Q19275_CAEEL; WBGene00017302; WP:CE01237; WP:CE29259; WP:CE29260 F09F7.8 F09F7.8 nspb-12; F09F7.8; 3G656; CE38594; Q19279_CAEEL; WBGene00017305; WP:CE38594 nspb family F09G2.1 F09G2.1 F09G2.1; 5H685; CE30744; WBGene00017310; WP:CE30744 tyrosine protein kinase F10D11.4 F10D11.4 F10D11.4; 1J16; CE09326; WBGene00008650; WP:CE09326 F10D2.9 F10D2.9 fat-7; F10D2.9; 5H632; CE09320; NM_072413; WBGene00001399; WP:CE09320 fat-7 encodes an essential delta-9 fatty acid desaturase that is required for the synthesis of monounsaturated fatty acids; fat-7 can substitute for the functions of the other two fatty acid desaturases, fat-5 and fat-6; RNA interference has shown that fat-7 is required for viability and normal growth. stearoyl-CoA desaturase F10G8.5 F10G8.5 ncs-2; F10G8.5; 1K610; CE09340; NCS2_CAEEL; NM_060250; WBGene00003564; WP:CE09340 NCS-2 neuronal calcium sensor protein F11A3.1 F11A3.1 F11A3.1; F11A3.1.1; F11A3.1.2; 5J989; CE05585; WBGene00008669; WP:CE05585 4-coumarate-CoA ligase F11G11.10 F11G11.10 col-17; F11G11.10; 2F156; CE31783; NM_062477; WBGene00000606; WP:CE31783 col-17 encodes a collagen which is expressed in all developmental stages except eggs, like col-15, col-16, and col-20; collagen genes with this expression pattern may be used for synthesis of cuticles after the L1 stage (e.g., the L4 cuticle). collagen F11G11.4 F11G11.4 F11G11.4; 2F151; CE07057; WBGene00017384; WP:CE07057 F11G11.8 F11G11.8 F11G11.8; 2F150; CE02882; WBGene00017386; WP:CE02882 F11G11.9 F11G11.9 F11G11.9; 2F152; CE09351; THT1_CAEEL; WBGene00017387; WP:CE09351 F11H8.3 F11H8.3 col-8; F11H8.3; 3I110; CE04376; COL8_CAEEL; NM_066132; WBGene00000597; WP:CE04376; col8 col-8 encodes a collagen, individually dispensable for viability and gross morphology, which is specifically expressed in dauers and adults but not in eggs or L4 larvae, like col-7, col-18, and col-19; the amino- and carboxyl-terminal cysteine-rich regions of COL-8 are most closely related to those of COL-19, COL-35, and COL-39. F12B6.2 F12B6.2 F12B6.2; F12B6.2b.1; F12B6.2b.2; 1C821; CE30273; CE30512; CE30513; CE39012; WBGene00017398; WP:CE30273; WP:CE30512; WP:CE30513; WP:CE39012 sodium dependent-phosphate transporter F13D2.1 F13D2.1 F13D2.1; CE37347; WBGene00008735; WP:CE37347; XL784 alpha-1-macroglobulin-like domain F13G3.5 F13G3.5 F13G3.5; F13G3.5.1; F13G3.5.2; 1H878; CE29761; IMPA1_CAEEL; WBGene00008765; WP:CE29761 myo-inositol-1-monophosphatase F14D7.7 F14D7.7 F14D7.7; 5O788; CE09385; WBGene00008794; WP:CE09385 F14F7.1 F14F7.1 col-98; F14F7.1; F14F7.1.1; F14F7.1.2; 3O109; CE15821; NM_067302; WBGene00000673; WP:CE15821 collagen F14H8.1 F14H8.1 obr-2; F14H8.1; 5P492; CE35859; NM_074294; WBGene00008832; WP:CE35859 oxysterol-binding protein F15B9.1 F15B9.1 far-3; F15B9.1; 5N476; CE09406; NM_073850; WBGene00001387; WP:CE09406 O.volvulus antigen peptide like F15H10.1 F15H10.1 col-12; F15H10.1; F15H10.1.1; F15H10.1.2; 5K904; CE05638; COL12_CAEEL; NM_073277; WBGene00000601; WP:CE05638 col-12 encodes a member of the collagen superfamily containing collagen triple helix repeats (20 copies); expressed throughout development but expression peaks after each larval molt when new cuticle is being secreted and deposited, and after the L4 to adult larval molt. collagen F17C8.3 F17C8.3 F17C8.3; 3F825; CE35179; WBGene00008910; WP:CE35179 F17E9.5 F17E9.5 F17E9.5; 4J111; CE07072; O61521_CAEEL; WBGene00017542; WP:CE07072 F19B10.9 F19B10.9 sea-1; tbx-18; F19B10.9; CE09476; TBX18_CAEEL; WBGene00004750; WP:CE09476 F19B2.5 F19B2.5 F19B2.5; F19B2.C; 5U632; CE20697; WBGene00008944; WP:CE20697 F19H6.4 F19H6.4 F19H6.4; CE03235; WBGene00008959; WP:CE03235; XM985 3-oxo-5-alpha-steroid 4-dehydrogenase F20D6.6 F20D6.6 F20D6.6; 5I641; CE07111; WBGene00017636; WP:CE07111 serine/threoninie protein phophatase F21C10.7 F21C10.7 F21C10.7; 5J601; CE07122; WBGene00017657; WP:CE07122 F21C3.5 F21C3.5 F21C3.5; 1H860; CE05680; PFD6_CAEEL; WBGene00009004; WP:CE05680 Mouse KE2 protein like F21F8.4 F21F8.4 F21F8.4; F21F8.4.1; F21F8.4.2; 5I751; CE09540; WBGene00017678; WP:CE09540 protease F21H12.5 F21H12.5 fbf-2; F21H12.5; 2G380; CE01916; FBF2_CAEEL; NM_062819; WBGene00001402; WP:CE01916 fbf-2 encodes an RNA-binding protein that is one of 11 C. elegans members of the PUF family (Pumilio and FBF) of translational regulators; FBF-2 is nearly identical to FBF-1 with which it is largely redundant in regulating two aspects of germline development: 1)maintenance of stem cell proliferation, and 2)the hermaphroditic switch between spermatogenesis and oogenesis; in maintaining germline stem cells, the FBF proteins, acting through NOS-3, negatively regulate the activity of gld-1 mRNA, which encodes a translational repressor required for meiotic entry; in regulating the sperm-to-oocyte switch, the FBFs act downstream of GLD-3 to negatively regulate the activity of fem-3 mRNA, which encodes a novel protein required for germline sex determination; consistent with their role in germline development, FBF-1 and FBF-2 are expressed in the germline cytoplasm, becoming enriched in the mitotic region during the L4 larval and adult stages. F21H7.2 F21H7.2 F21H7.2; F21H7.2.1; F21H7.2.2; 5Q708; CE15875; WBGene00009028; WP:CE15875 F21H7.5 F21H7.5 F21H7.5; 5Q719; CE15877; WBGene00009031; WP:CE15877 F22A3.1 F22A3.1 ets-4; F22A3.1; CE34001; WBGene00017687; WP:CE34001; XH139 DNA binding protein, ETS domain F22G12.5 F22G12.5 F22G12.5; 1N773; CE15892; WBGene00009065; WP:CE15892 F23B12.1 F23B12.1 F23B12.1; 5O909; CE09593; WBGene00009079; WP:CE09593 serine/threonine protein phosphatase F25D1.5 F25D1.5 F25D1.5; 5L26; CE05726; Q19774_CAEEL; WBGene00009110; WP:CE05726 dehydrogenase F25E5.8 F25E5.8 F25E5.8; F25E5.8a.1; F25E5.8a.2; F25E5.8b.1; F25E5.8b.2; 5H917; CE07142; CE32876; WBGene00017789; WP:CE07142; WP:CE32876 F26A1.4 F26A1.4 F26A1.4; 3F903; CE02685; WBGene00017803; WP:CE02685 Casein kinase F26A3.5 F26A3.5 F26A3.5; 1I245; CE09670; WBGene00009143; WP:CE09670 F26F4.2 F26F4.2 F26F4.2; 3G1; CE29288; Q19823_CAEEL; WBGene00005012; WP:CE29288 spt-2 encodes a novel protein with high similarity to C. elegans F37A8.1 and C. briggsae CBG18186. F26G1.5 F26G1.5 F26G1.5; 2F60; CE02697; WBGene00017841; WP:CE02697 F26G1.7 F26G1.7 msp-3; F26G1.7; 2F76; CE02699; MSP3_CAEEL; NM_062457; WBGene00003424; WP:CE02699 msp-3 encodes a protein that belongs to a family of proteins called the Major Sperm Proteins (MSPs) that is conserved in nematodes; msp-3 is similar in nucleotide sequence to the msp genes from the nematode Onchocerca volvulus; the msp gene family consists of closely related, small, basic proteins that make up 15% of sperm protein; this multigene family consists of over fifty genes, including many pseudogenes; MSPs are involved in both extracellular signaling and cytoskeletal functions during reproduction-MSP antagonizes Eph/ephrin signaling, in part, by binding VAB-1 Eph receptor tyrosine kinase on oocytes and sheath cells to promote oocyte maturation and MAPK activation; MSP proteins assemble into fibrous networks that drive movement of the C. elegans sperm; msp genes are expressed only in late primary spermatocytes. Major sperm protein F27B3.5 F27B3.1 F27B3.5; 3H650; CE28010; WBGene00017847; WP:CE28010 F27C1.1 F27C1.1 F27C1.1; 1G3; CE09714; WBGene00017851; WP:CE09714 F27C8.4 F27C8.4 spp-18; F27C8.4; 4K359; CE03269; NM_069303; WBGene00005003; WP:CE03269 F27D4.4 F27D4.4 F27D4.4; 1I303; CE36141; WBGene00009189; WP:CE36141 Yeast hypothetical protein YOR316OW like F28D1.5 F28D1.5 thn-2; F28D1.5; 4N149; CE05745; NM_069961; WBGene00009215; WP:CE05745 Arabidopsis pathogenesis-related protein 5 like F28E10.4 F28E10.4 F28E10.4; 4F332; CE04461; WBGene00017902; WP:CE04461 F28F5.3 F28F5.2 tag-204; F28F5.3; 3H905; CE29296; CE29297; CE30771; Q8MNT0_CAEEL; WBGene00017904; WP:CE29296; WP:CE29297; WP:CE30771 F28F5.4 F28F5.4 F28F5.4; CE00791; WBGene00043297; WP:CE00791 F29D10.2 F29D10.2 F29D10.2; 1J419; CE38335; WBGene00009251; WP:CE38335 F29G9.1 F29G9.1 F29G9.1; 5G519; CE35297; WBGene00017930; WP:CE35297 F31E8.5 F31E8.5 F31E8.5; 2H94; CE35516; WBGene00017955; WP:CE35516 F32A11.3 F32A11.3 F32A11.3; 2N442; CE17739; WBGene00009308; WP:CE17739 F32B4.2 F32B4.2 F32B4.2; 1M104; CE36146; WBGene00009313; WP:CE36146 F32B5.1 F32B5.1 F32B5.1; 1D269; CE28230; WBGene00017975; WP:CE28230 phosphotransferase F32B6.5 F32B6.5 sss-1; F32B6.5; 4K658; CE09860; NM_069379; Q9XVP7_CAEEL; WBGene00006056; WP:CE09860 F32B6.6 F32B6.6 msp-77; F32B6.6; 4K659; CE09861; NM_069380; WBGene00003464; WP:CE09861 msp-77 encodes a protein that belongs to a family of proteins called the Major Sperm Proteins (MSPs) that is conserved in nematodes; this family consists of closely related, small, basic proteins that make up 15% of sperm protein; this multigene family consists of over fifty genes, including many pseudogenes; MSPs are involved in both extracellular signaling and cytoskeletal functions during reproduction-MSP antagonizes Eph/ephrin signaling, in part, by binding VAB-1 Eph receptor tyrosine kinase on oocytes and sheath cells to promote oocyte maturation and MAPK activation; MSPs assemble into fibrous networks that drive movement of the C. elegans sperm; msp genes are expressed only in late primary spermatocytes. major sperm protein F32D1.5 F32D1.5 F32D1.5; F32D1.5.1; F32D1.5.2; 5E848; CE09869; GMPR_CAEEL; WBGene00017984; WP:CE09869 GMP reductase F32G8.6 F32G8.6 cat-4; F32G8.6; 5L45; CE05795; GCH1_CAEEL; NM_073309; WBGene00000298; WP:CE05795 cat-4 encodes an ortholog of the human GTP cyclohydrolase I gene (GCH1; OMIM:600225), which when mutated leads to dystonia; CAT-4 is involved in serotonin and dopamine biosynthesis that affects movement, mating behavior, foraging behavior, and cell migration; CAT-4 acts in the same genetic pathway as flp-1. GTP cyclohydrolase I F32H5.1 F32H5.1 F32H5.1; 5N836; CE09885; WBGene00009347; WP:CE09885 cathepsin B like cysteine protease F33D11.2 F33D11.2 F33D11.2; 1G425; CE09892; WBGene00018001; WP:CE09892 F33D11.7 F33D11.7 F33D11.7; 1G426; CE09897; WBGene00018004; WP:CE09897 protein kinase F33D4.1 F33D4.1 nhr-8; F33D4.1; 4I477; CE33927; CE33928; NHR8_CAEEL; NM_171382; WBGene00003607; WP:CE33927; WP:CE33928 The nhr-8 gene encodes a nuclear hormone receptor homolog; nhr-8(ok186) mutants have abnormally low resistance to the toxins colchicine and chloroquine. F33H1.4 F33H1.4 F33H1.4; 2K469; CE02206; WBGene00009365; WP:CE02206 F34D10.2 F34D10.2 F34D10.2; F34D10.2.1; F34D10.2.2; 3E820; CE01570; WBGene00009372; WP:CE01570 F34D6.4 F34D6.4 F34D6.4; 2C980; CE36838; WBGene00018023; WP:CE36838 F35B12.3 F35B12.3 F35B12.3; CE31929; NM_073541; WBGene00009383; WP:CE31929 F35C11.2 F35C11.2 F35C11.2; 2I534; CE02209; WBGene00009401; WP:CE02209 protein-tyrosine phosphatase F35C11.3 F35C11.3 F35C11.3; 2I537; CE02210; WBGene00009402; WP:CE02210 serine/threonine kinase F35C5.5 F35C5.5 clec-62; F35C5.5; 2N184; CE15945; CE15946; WBGene00009393; WP:CE15945; WP:CE15946 Lectin C-type domain short and long forms, von Willebrand factor type A domain F35C8.6 F35C8.6 pfn-2; F35C8.6; CE39098; NM_076509; PROF2_CAEEL; WBGene00003990; WP:CE39098; XF972 F36A2.11 F36A2.11 F36A2.11; 1J399; CE34181; WBGene00009458; WP:CE34181 F36A2.14 F36A2.12 F36A2.14; 1J400; CE37233; WBGene00023490; WP:CE37233 F36A4.10 F36A4.10 alpha-collagen; col-34; ram-4; F36A4.10; 4F8; CE07185; COL34_CAEEL; NM_068119; WBGene00000611; WP:CE07185 col-34 encodes a cuticle collagen protein and is a critical component of male tail cuticle organization affecting ray morphology. cuticular collagen F36A4.4 F36A4.4 F36A4.4; 4F33; CE07180; WBGene00018083; WP:CE07180 F36A4.6 F36A4.6 col-33; F36A4.6; 4F29; CE34548; NM_068123; WBGene00000610; WP:CE34548 col-33 encodes a predicted cuticular collagen; by homology, col-33 is predicted to play a role in cuticle biosynthesis and regulation of body size and morphogenesis; however, as loss of col-33 activity via large-scale RNAi screens does not result in any obvious abnormalities, the precise role of COL-33 in C. elegans development and/or behavior is not yet known. cuticular collagen F36G3.2 F36G3.2 F36G3.2; CE01577; WBGene00009483; WP:CE01577; XK412; YQY2_CAEEL F36H12.10 F36H12.10 F36H12.10; 4G18; CE09981; WBGene00018124; WP:CE09981 F36H12.3 F36H12.3 F36H12.3; 4G39; CE09975; WBGene00018119; WP:CE09975 F36H12.7 F36H12.7 msp-19; F36H12.7; 4G25; CE02806; NM_068359; WBGene00003426; WP:CE02806 msp-19 encodes a protein that belongs to a family of proteins called the Major Sperm Proteins (MSPs) that is conserved in nematodes; msp-19 has a homolog in C. briggsae as predicted by the Wobble Aware Bulk Aligner (WABA); the msp gene family consists of closely related, small, basic proteins that make up 15% of sperm protein; this multigene family consists of over fifty genes, including many pseudogenes; MSPs are involved in both extracellular signaling and cytoskeletal functions during reproduction-MSP antagonizes Eph/ephrin signaling, in part, by binding VAB-1 Eph receptor tyrosine kinase on oocytes and sheath cells to promote oocyte maturation and MAPK activation; MSPs assemble into fibrous networks that drive movement of the C. elegans sperm; msp genes are expressed only in late primary spermatocytes. major sperm protein MSP-19 F36H12.8 F36H12.8 F36H12.8; 4G23; CE09979; WBGene00018122; WP:CE09979 F36H12.9 F36H12.9 F36H12.9; 4G21; CE09980; WBGene00018123; WP:CE09980 F38A3.2 F38A3.2 col-82; ram-2; ram-3; F38A3.2; 2L306; CE02214; NM_063961; WBGene00004300; WP:CE02214 ram-2 encodes a cuticle collagen that interacts with unc-6 to affect ray cell migration, and interacts with unc-5 and unc-6 to affect embryonic viability; also affects ray morphology in males such that the structural cells and the hypodermis of the rays are swollen in mutants. collagen F38H4.6 F38H4.6 F38H4.6; 4M612; CE10068; WBGene00009550; WP:CE10068 F40E10.5 F40E10.5 F40E10.5; CE05840; NM_078040; WBGene00009573; WP:CE05840; XP321 F40F4.6 F40F4.6 F40F4.6; CE04536; WBGene00018237; WP:CE04536; XD856 EGF-like repeats F40F8.7 F40F8.7 pqm-1; pqm-132; F40F8.7; 2L442; CE05846; CePqM132; NM_063990; WBGene00004096; WP:CE05846 pqm-1 encodes a C2H2-type zinc finger and leucine zipper-containing protein that is upregulated in response to oxidative stress induced by paraquat treatment; PQM-1 may function as a stress-responsive transcription factor. Zinc finger, C2H2 type F40F9.2 F40F9.2 tag-120; F40F9.2; 5K188; CE05851; WBGene00006470; WP:CE05851 tag-120 encodes a predicted transmembrane protein; as loss of tag-120 activity via RNAi does not result in any abnormalities, the precise role of TAG-120 in C. elegans development and/or behavior is not yet known; however, TAG-120 is homologous to a Drosophila NMDA receptor-associated protein and mammalian transmembrane proteins that function in Fas-mediated cell death, so TAG-120 may play a role in neuronal functions and/or apoptosis; a tag-120 reporter fusion is expressed in the nervous system, pharyngeal muscles, and to a lesser extent in the excretory system. N-methyl-D-aspartate receptor associated protein F40F9.3 F40F9.3 F40F9.3; 5K195; CE05852; WBGene00009581; WP:CE05852 PDZ domain (Also known as DHR or GLGF). F40G12.10 F40G12.10 F40G12.10; 5O765; CE10194; WBGene00009605; WP:CE10194 protein-tyrosine phosphatase F41E6.11 F41E6.11 F41E6.11; 5J100; CE10264; WBGene00018292; WP:CE10264 F42A10.7 F42A10.7 F42A10.7; F42A10.7.1; F42A10.7.2; 3H268; CE01298; WBGene00018343; WP:CE01298 F42E8.2 F42E8.2 F42E8.2; 5N544; CE10304; WBGene00009631; WP:CE10304 F42G8.3 F42G8.3 pmk-2; F42G8.3; 4I911; CE31695; CE34862; NM_171392; NM_171913; PMK2_CAEEL; WBGene00004056; WP:CE31695; WP:CE34862 The pmk-2 gene encodes a homolog of p38, a type of mitogen-activated protein kinase (MAPK) that in mammals is generally activated by diverse cellular stresses and ligands. F42G9.1 F42G9.1 F42G9.1; 3B403; CE07231; CE30788; PP2C1_CAEEL; WBGene00018362; WP:CE07231; WP:CE30788 Protein phosphatase F42H11.1 F42H11.1 F42H11.1; 1K153; CE10330; WBGene00009646; WP:CE10330 F42H11.2 F42H11.2 lem-3; F42H11.2; F42H11.2.1; F42H11.2.2; 1K156; CE10332; NM_060138; WBGene00002276; WP:CE10332 ankyrin domain F43G9.10 F43G9.10 F43G9.10; 1J216; CE10372; WBGene00009671; WP:CE10372 MICROFIBRILLAR-ASSOCIATED PROTEIN 1 (ASSOCIATED MICROFIBRIL PROTEIN) (AMF) F43H9.2 F43H9.2 sptl-2; F43H9.2; 5I501; CE07246; CE27380; WBGene00018398; WP:CE07246; WP:CE27380 serine palmtoyltransferase F44B9.8 F44B9.8 F44B9.8; 3J118; CE37518; RFC5_CAEEL; WBGene00018409; WP:CE37518 ARPA F44C4.3 F44C4.3 cpr-4; F44C4.3; F44C4.3.1; F44C4.3.2; 5H95; CE07251; CPR4_CAEEL; NM_072281; WBGene00000784; WP:CE07251 cpr-4 encodes a cathepsin B-like cysteine protease expressed at all life stages. cathepsin B-like cysteine proteinase 4 precursor F44D12.7 F44D12.7 F44D12.7; 4K799; WBGene00009684 F44F4.10 F44F4.10 F44F4.10; 2L206; CE00997; WBGene00009705; WP:CE00997 F45C12.7 F45C12.7 F45C12.7; 2C5; CE10448; WBGene00018438; WP:CE10448 F45D3.4 F45D3.4 F45D3.4; 5N32; CE10474; CE38518; WBGene00009724; WP:CE10474; WP:CE38518 F45E4.1 F45E4.1 arf-1.1; arl-6; F45E4.1; 4I401; ARF11_CAEEL; CE10492; NM_068841; WBGene00000190; WP:CE10492 arf-1.1 encodes a member of the ADP-ribosylation factor family. ADP-ribosylation factor F45E6.5 F45E6.5 F45E6.5; WBGene00043329 F46B6.7 F46B6.7 ztf-7; F46B6.7; F46B6.7.1; F46B6.7.2; 5K268; CE05873; WBGene00009772; WP:CE05873 Zinc finger, C2H2 type F46C8.1 F46C8.1 F46C8.1; CE04576; WBGene00018484; WP:CE04576; XI169 F46C8.6 F46C8.6 dpy-7; F46C8.6; F46C8.6.1; F46C8.6.2; CE04580; DPY7_CAEEL; NM_076873; WBGene00001069; WP:CE04580; XI156 dpy-7 encodes a cuticular collagen; DPY-7 functions as a structural constituent of the extracellular cuticle whose activity is required for normal cuticular morphology and hence, proper body form. cuticle collagen F46G10.5 F46G10.5 ptr-24; F46G10.5; CE31522; NM_077821; WBGene00004238; WP:CE31522; XN965 ptr-24 encodes a nematode-specific member of the sterol sensing domain (SSD) proteins, distantly paralogous to Drosophila PATCHED (PTC) and human PTCH (OMIM:601309, mutated in basal cell nevus syndrome); PTR-24 has no known function in vivo. F46G10.6 F46G10.6 hlh-23; mxl-3; F46G10.6; CE05882; NM_077822; WBGene00003511; WP:CE05882; XN968 Helix-loop-helix DNA-binding domain F47B3.1 F47B3.1 F47B3.1; 1E541; CE10616; WBGene00018525; WP:CE10616 protein-tyrosine phosphatase F47B3.4 F47B3.4 F47B3.4; 1E529; CE10622; WBGene00018528; WP:CE10622 F47B3.5 F47B3.5 F47B3.5; 1E530; CE10624; WBGene00018529; WP:CE10624 F47B3.6 F47B3.6 F47B3.6; 1E534; CE36648; WBGene00018530; WP:CE36648 F47B3.7 F47B3.7 F47B3.7; 1E536; CE10628; WBGene00018531; WP:CE10628 F47B8.11 F47B8.11 sss-2; F47B8.11; 5O827; CE10652; NM_074156; WBGene00006057; WP:CE10652 F47C12.4 F47C12.4 clec-79; F47C12.4; 4E739; CE10676; WBGene00018548; WP:CE10676 F47G4.7 F47G4.7 smd-1; F47G4.7; F47G4.7.1; F47G4.7.2; 1O640; CE18705; DCAM_CAEEL; NM_061047; WBGene00004875; WP:CE18705; samdc F48C1.7 F48C1.7 spe-11; F48C1.7; 1F900; CE10744; NM_059168; SPE11_CAEEL; WBGene00004965; WP:CE10744 spe-11 encodes a novel protein that is required for early embryonic development and for regulating the dynamic morphology of sperm pseudopods; although the precise biological role of SPE-11 is not yet known, SPE-11 is one of the few paternally provided proteins known to be essential for embryogenesis, and may constitute a sperm-associated factor required for oocyte activation; SPE-11 is first detected in the nuclei of primary spermatocytes and then remains tightly associated with sperm chromatin until fertilization at which point it appears to be degraded. F49C12.15 F49C12.15 F49C12.15; 4K91; CE03375; WBGene00009884; WP:CE03375 F52B10.1 F52B10.1 nmy-1; F52B10.1; CE31177; NM_076103; Q20641_CAEEL; WBGene00003776; WP:CE31177; XD535 nmy-1 encodes a class II non-muscle myosin heavy chain related to Drosophila zipper, which plays a role in several aspects of embryonic morphogenesis; in C. elegans, NMY-1 is required for embryonic elongation and establishment of normal body morphology; however, nmy-1 functions redundantly with another non-muscle myosin heavy chain gene, nmy-2, during elongation and establishment of normal body morphology; mutations in nmy-1 suppress the hypercontraction phenotype produced by mutations in mel-11, a myosin phosphatase that regulates actomyosin filament contraction; in addition, NMY-1 may partner with MLC-4, myosin light chain 4, during elongation; NMY-1 expression is detected during embryogenesis, particularly at the onset of elongation. myosin F52E1.14 F52E1.5 F52E1.14; CE04633; WBGene00044696; WP:CE04633 F52F12.5 F52F12.5 F52F12.5; 1K496; CE10848; WBGene00009938; WP:CE10848 F53A9.6 F53A9.6 F53A9.6; F53A9.6.1; F53A9.6.2; CE02766; WBGene00018729; WP:CE02766; XJ332 F53B3.5 F53B3.4 F53B3.5; CE30142; WBGene00018743; WP:CE30142; XD492 F53B3.5 encodes a claudin homolog that may regulate ion channels; F53B3.5 is distantly similar to mammalian voltage-dependent calcium channel gamma subunits that are known or suspected to prevent epilepsy in vivo (e.g., stargazin; MGI:1316660); F53B3.5 has no obvious function in mass RNAi assays; claudins are integral membrane proteins with four transmembrane sequences that are found in mammalian tight junctions (TJs), induce TJs when transgenically expressed in cells normally lacking them, and can mediate the specific conductance of of specific ions (e.g., magnesium or calcium) through TJs while blocking the flow of water. F53F10.3 F53F10.3 F53F10.3; F53F10.3.1; F53F10.3.2; 1E395; CE28447; WBGene00018765; WP:CE28447; YXX3_CAEEL F53G12.8 F53G12.8 F53G12.8; 1A587; CE36697; WBGene00018773; WP:CE36697 F54C1.8 F54C1.8 F54C1.8; 1F574; CE34315; WBGene00018792; WP:CE34315 F54C9.9 F54C9.9 F54C9.9; 2I871; CE20865; WBGene00010044; WP:CE20865 F54D1.1 F54D1.1 F54D1.1; 4M25; CE05936; WBGene00010046; WP:CE05936 F54D5.3 F54D5.3 F54D5.3; F54D5.3.1; F54D5.3.2; 2L863; CE28033; WBGene00010049; WP:CE28033 F54D5.9 F54D5.9 F54D5.9; 2L834; CE03413; WBGene00010053; WP:CE03413 This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins. F54D8.6 F54D8.6 F54D8.6; 3G195; CE31000; Q8MQ25_CAEEL; WBGene00018802; WP:CE31000 F54F7.3 F54F7.3 F54F7.3; CE03418; WBGene00010065; WP:CE03418; XM468 F55C10.2 F55C10.2 col-154; F55C10.2; 5L865; CE05952; NM_073485; WBGene00000727; WP:CE05952 collagen F55C10.3 F55C10.3 col-155; F55C10.3; 5L868; CE11182; CO155_CAEEL; NM_073487; WBGene00000728; WP:CE11182 collagen F55C12.1 F55C12.1 F55C12.1; F55C12.1a.1; F55C12.1a.2; F55C12.1d.1; F55C12.1d.2; 2G181; CE02770; CE28452; CE31958; CE31959; Q95ZS6_CAEEL; WBGene00018869; WP:CE02770; WP:CE28452; WP:CE31958; WP:CE31959 F55C12.3 F55C12.3 F55D10.2 F55D10.2 rpl-25.1; F55D10.2; F55D10.2.1; F55D10.2.2; CE02777; NM_076407; R23A1_CAEEL; WBGene00004438; WP:CE02777; XF335 rpl-25.1 encodes a large ribosomal subunit L23a protein. Ribosomal protein L23 F55D12.6 F55D12.6 F55D12.6; 1I479; CE17876; WBGene00010114; WP:CE17876 F55F8.7 F55F8.7 F55F8.7; 1G228; CE11200; WBGene00018895; WP:CE11200 protein-tyrosine phosphatase F56B3.1 F56B3.1 col-103; F56B3.1; 4B516; CE17882; NM_067581; WBGene00000677; WP:CE17882 F56D6.2 F56D6.2 clec-67; F56D6.2; 4E687; CE31546; WBGene00018971; WP:CE31546 F56F10.1 F56F10.1 F56F10.1; F56F10.1.1; F56F10.1.2; CE34034; WBGene00018984; WP:CE34034; XB493; YM9I_CAEEL peptidase F56F3.4 F56F3.4 F56F3.4; 3F561; CE01016; WBGene00010155; WP:CE01016 Ubiquitin family F57B7.3 F57B7.3 col-156; F57B7.3; 5L930; CE05991; NM_073501; WBGene00000729; WP:CE05991 collagen F57B9.6 F57B9.6 inf-1; F57B9.6; F57B9.6a.1; F57B9.6a.2; 3I21; CE01341; CE38524; Ce1F; CeIF; IF4A_CAEEL; NM_066108; WBGene00002083; WP:CE01341; WP:CE38524 inf-1 encodes a protein with high similarity to eukaryotic initiation factor 4A. F57F4.3 F57F4.3 gfi-1; F57F4.3; 5G882; CE11342; NM_072225; WBGene00001581; WP:CE11342 gfi-1 encodes a protein that contains 21 ET modules; interacts with unc-68 in yeast two-hybrid assays. F57F4.4 F57F4.4 F57F4.4; F57F4.4.1; F57F4.4.2; F57F4.4.3; CE11344; NM_072226; WBGene00019017; WP:CE11344 F58A6.11 F58A6.11 srb-13; F58A6.11; 2F446a; CE07297; NM_062557; WBGene00019028; WP:CE07297 7TM chemoreceptor, srb family F58A6.8 F58A6.8 msp-45; F58A6.8; 2F446; NM_062558; WBGene00003438 msp-45 encodes a member of the major sperm protein family. major sperm protein F58A6.9 F58A6.9 F58A6.9; 2F448; WBGene00019026 major sperm protein F58B3.1 F58B3.1 lys-4; F58B3.1; 4M386; CE06003; NM_069791; WBGene00003093; WP:CE06003 F58D2.2 F58D2.2 F58D2.2; 4N955; CE11364; WBGene00010241; WP:CE11364 F58E6.5 F58E6.5 F58E6.5; 5K234; CE06020; WBGene00010254; WP:CE06020 F58E6.7 F58E6.7 F58E6.7; 5K237; CE38525; WBGene00010256; WP:CE38525 F58F6.1 F58F6.1 col-104; F58F6.1; 4C118; CE17136; NM_067669; WBGene00000678; WP:CE17136 cuticular collagen F58G1.3 F58G1.3 F58G1.3; 2N218; CE35562; O62272_CAEEL; WBGene00010265; WP:CE35562 Protein phosphatase-1 (PP1) (2 domains) F58H7.8 F58H7.8 F58H7.8; 4B663; CE17936; WBGene00019073; WP:CE17936 F59A1.10 F59A1.10 F59A1.10; 5S141; CE18794; WBGene00010296; WP:CE18794 F59A2.3 F59A2.3 F59A2.3; F59A2.3.1; F59A2.3.2; 3E487; CE17940; WBGene00010303; WP:CE17940; YMI3_CAEEL Splicing factor-associated 32K chain F59D8.B F59D8.B F59D8.1 F59D8.F vit-3; F59D8.1; F59D8.A; F59D8.E; F59D8.F; CE20900; NM_076212; VIT3_CAEEL; WBGene00006927; WP:CE20900; XE184 vit-3 encodes a vitellogenin, a precursor of the lipid-binding protein related to vertebrate vitellogenins and mammalian ApoB-100, a core LDL particle constituent (OMIM:107730); VIT-3 is a major yolk component, but as loss of VIT-3 activity via RNA-mediated interference (RNAi) does not result in any abnormalities, VIT-3 likely functions redundantly with other vitellogenins to provide essential nutrients to the developing embryo; VIT-3 is expressed exclusively in the adult hermaphrodite intestine, from which it is secreted into the pseudocoelomic space and finally taken up by oocytes; in males, vit-3 expression may be negatively regulated by MAB-3, a DM binding domain-containing transcription factor required for male sexual development. F59E12.1 F59E12.1 F59E12.1; 2F947; CE28569; WBGene00019118; WP:CE28569 F59E12.12 F59E12.12 bli-2; F59E12.12; 2F940; CE11540; NM_062703; WBGene00000252; WP:CE11540 A cuticle collagen involved in strut assembly in the adult cuticle. H03E18.1 H03E18.1 H03E18.1; CE37653; WBGene00019148; WP:CE37653; XJ131 H06I04.3 H06I04.H H06I04.3; H06I04.3c.1; H06I04.3c.2; 3E173; CE23795; CE38200; CE38201; WBGene00019168; WP:CE23795; WP:CE38200; WP:CE38201 H15N14.2 H15N14.1 nsf-1; H15N14.2; 1I344; CE19925; NM_170902; NSF_CAEEL; WBGene00003818; WP:CE19925 vesicular-fusion protein NSF H17B01.2 H17B01.2 col-70; H17B01.2; 2B759; CE11592; NM_061577; WBGene00000646; WP:CE11592 collagen K01C8.1 K01C8.1 K01C8.1; K01C8.1.1; K01C8.1.2; K01C8.1.3; 2I557; CE36943; WBGene00010456; WP:CE36943 threonine dehydratase K01D12.11 K01D12.11 cdr-4; K01D12.11; 5M886; CE06050; NM_073709; WBGene00010470; WP:CE06050 glutathione S-transferase K01D12.15 K01D12.15 K01D12.15; 5M867; CE28043; WBGene00010474; WP:CE28043 K01D12.7 K01D12.7 K01D12.7; 5M882; CE28483; WBGene00010466; WP:CE28483 K01D12.8 K01D12.8 K01D12.8; 5M883; CE34199; WBGene00010467; WP:CE34199 K01G5.3 K01G5.3 K01G5.3; 3L841; CE16193; WBGene00010477; WP:CE16193 K01G5.4 K01G5.4 ran-1; K01G5.4; K01G5.4.1; K01G5.4.2; K01G5.4.3; 3L836; CE16194; NM_066968; RAN_CAEEL; WBGene00004302; WP:CE16194 GTP-binding protein K02D7.3 K02D7.3 col-101; K02D7.3; 4B78; CE17996; NM_067504; WBGene00000675; WP:CE17996 cuticular collagen K02E2.6 K02E2.6 K02E2.6; K02E2.6.1; K02E2.6.2; 5U851; CE23845; WBGene00010507; WP:CE23845 K02F3.4 K02F3.4 zip-2; K02F3.4; K02F3.4.1; K02F3.4.2; 3B453; CE23848; WBGene00019327; WP:CE23848 K03B8.8 K03B8.8 K03B8.8; 5L886; CE06082; WBGene00010525; WP:CE06082 K03H1.10 K03H1.10 K03H1.10; K03H1.10.1; K03H1.10.2; 3L15; CE00571; WBGene00010545; WP:CE00571 K04F1.1 K04F1.1 K04F1.1; 5C132; CE36877; WBGene00019384; WP:CE36877 K04H4.1 K04H4.1 clb-2; emb-9; zyg-6; K04H4.1; 3K428; CE36389; CE36390; CO4A1_CAEEL; WBGene00001263; WP:CE36389; WP:CE36390 emb-9 encodes the alpha-1 chain of Type IV basement membrane collagen most closely equivalent to human COL4A1 (OMIM:120130) on the basis of biological function; EMB-9 forms heterotrimeric Type IV collagen with LET-2, the alpha-2-like chain, and is required for the assembly and/or secretion of LET-2; EMB-9 is essential for embryonic morphogenesis, particularly epidermal elongation, and for larval development; EMB-9 is expresed primarily by body wall muscles and some somatic cells of the gonad and is detected in nearly all basement membranes. collagen K05C4.1 K05C4.1 pbs-5; K05C4.1; K05C4.1.1; K05C4.1.2; 1P310; CE19969; NM_061157; WBGene00003951; WP:CE19969 Proteasome A-type and B-type K05F1.2 K05F1.2 msp-142; K05F1.2; 2G89; MSP19_CAEEL; NM_062743; WBGene00003469 msp-142 encodes a protein that belongs to a family of proteins called the Major Sperm Proteins (MSPs) that is conserved in nematodes; this family consists of closely related, small, basic proteins that make up 15% of sperm protein; this multigene family consists of over fifty genes, including many pseudogenes; MSPs are involved in both extracellular signaling and cytoskeletal functions during reproduction-MSP antagonizes Eph/ephrin signaling, in part, by binding VAB-1 Eph receptor tyrosine kinase on oocytes and sheath cells to promote oocyte maturation and MAPK activation; MSPs assemble into fibrous networks that drive movement of the C. elegans sperm; msp genes are expressed only in late primary spermatocytes. Major sperm protein (msp-142) K05F1.3 K05F1.3 K05F1.3; 2G85; CE02807; WBGene00019406; WP:CE02807 Acyl-coA dehydrogenase K05F1.7 K05F1.7 msp-63; K05F1.7; 2G86; CE02811; MSP63_CAEEL; NM_062742; WBGene00003456; WP:CE02811 msp-63 encodes a protein that belongs to a family of proteins called the Major Sperm Proteins (MSPs) that is conserved in nematodes; this family consists of closely related, small, basic proteins that make up 15% of sperm protein; this multigene family consists of over fifty genes, including many pseudogenes; MSPs are involved in both extracellular signaling and cytoskeletal functions during reproduction-MSP antagonizes Eph/ephrin signaling, in part, by binding VAB-1 Eph receptor tyrosine kinase on oocytes and sheath cells to promote oocyte maturation and MAPK activation; MSPs assemble into fibrous networks that drive movement of the C. elegans sperm; msp genes are expressed only in late primary spermatocytes. Major sperm protein K05F1.9 K05F1.9 K05F1.9; 2G90; CE02813; WBGene00019410; WP:CE02813 K05G3.3 K05G3.3 cah-3; K05G3.3; CAH3_CAEEL; CE04755; NM_078273; WBGene00000281; WP:CE04755; XR103 carbonic anhydrase 2. carbonic anhydrase K06H7.8 K06H7.8 K06H7.8; 3J186; CE25045; WBGene00019459; WP:CE25045; YMX8_CAEEL K07A1.10 K07A1.10 K07A1.10; 1K190; CE39387; WBGene00010616; WP:CE39387 K07A1.4 K07A1.4 K07A1.4; 1K166; CE11846; WBGene00010611; WP:CE11846 K07A1.5 K07A1.5 K07A1.5; 1K167; CE11848; WBGene00010612; WP:CE11848 K07E3.1 K07E3.1 K07E3.1; CE39593; WBGene00019490; WP:CE39593; XI733 K07F5.1 K07F5.1 msp-81; K07F5.1; 4K600; NM_069358; WBGene00003467 msp-81 encodes a member of the major sperm protein family. major sperm protein K07F5.11 K07F5.11 ssq-1; K07F5.11; 4K617; CE06125; NM_069367; WBGene00006050; WP:CE06125 K07F5.2 K07F5.2 msp-10; K07F5.2; 4K603; CE03853; NM_069359; WBGene00003425; WP:CE03853 msp-10 encodes a protein that belongs to a family of proteins called the Major Sperm Proteins (MSPs) that is conserved in nematodes; this family consists of closely related, small, basic proteins that make up 15% of sperm protein; this multigene family consists of over fifty genes, including many pseudogenes; MSPs are involved in both extracellular signaling and cytoskeletal functions during reproduction-MSP antagonizes Eph/ephrin signaling, in part, by binding VAB-1 Eph receptor tyrosine kinase on oocytes and sheath cells to promote oocyte maturation and MAPK activation; MSPs assemble into fibrous networks that drive movement of the C. elegans sperm; msp genes are expressed only in late primary spermatocytes. major sperm protein K07F5.5 K07F5.5 K07F5.5; 4K609; CE06120; WBGene00010633; WP:CE06120 K07F5.7 K07F5.7 K07F5.7; 4K612; CE06122; WBGene00010635; WP:CE06122 K07F5.9 K07F5.9 ssp-10; K07F5.9; 4K616; CE06124; NM_069366; SSP10_CAEEL; WBGene00006039; WP:CE06124 major sperm protein K08C9.4 K08C9.4 col-65; K08C9.4; 1M82; CE18860; NM_060535; WBGene00000641; WP:CE18860 K08D10.7 K08D10.7 K08D10.7; 4E931; CE07359; Q21319_CAEEL; WBGene00019530; WP:CE07359 K08D10.7 encodes a homolog of human scramblase (PLSCR1; OMIM:604170), which is activated by a rise of intracellular calcium, and which promotes the exposure of phosphatidylserine on the surface of cells undergoing activation, injury, or apoptosis; a close paralog of K08D10.7 is K08D10.8, and other paralogs include F46A8.9, F46A8.10, and Y50E8A.9> Exposure of phosphatidylserine on the surface of apoptotic cells occurs because of a phospholipid scramblase and inactivation of an aminophospolipid translocase that would normally keep the PS on the interior of the cell; by virtue of its similarity to mammalian scramblase, K08D10.7 may promote clearage of apoptotic cells by phagocytosis. K08D10.8 K08D10.8 K08D10.8; K08D10.8.1; K08D10.8.2; 4E929; CE07360; Q21318_CAEEL; WBGene00019531; WP:CE07360 K08D10.7 encodes a homolog of human scramblase (PLSCR1; OMIM:604170), which is activated by a rise of intracellular calcium, and which promotes the exposure of phosphatidylserine on the surface of cells undergoing activation, injury, or apoptosis; a close paralog of K08D10.8 is K08D10.7, and other paralogs include F46A8.9, F46A8.10, and Y50E8A.9> Exposure of phosphatidylserine on the surface of apoptotic cells occurs because of a phospholipid scramblase and inactivation of an aminophospolipid translocase that would normally keep the PS on the interior of the cell; by virtue of its similarity to mammalian scramblase, K08D10.8 may promote clearage of apoptotic cells by phagocytosis. K08D8.5 K08D8.5 K08D8.5; 4N676; CE06144; WBGene00010659; WP:CE06144 K08E3.1 K08E3.1 tyr-2; K08E3.1; 3O835; CE18864; NM_067435; WBGene00010661; WP:CE18864 tyrosinase K08F11.6 K08F11.6 K08F11.6; 4F492; WBGene00023323 K08F4.5 K08F4.5 K08F4.5; 4K898; CE06153; WBGene00010679; WP:CE06153 K09C6.8 K09C6.8 K09C6.8; 5B318; CE12002; WBGene00019562; WP:CE12002 K09E4.1 K09E4.1 K09E4.1; 2O429; CE19994; WBGene00010719; WP:CE19994 K09F5.2 K09F5.2 vit-1; K09F5.2; CE04746; NM_076904; VIT1_CAEEL; WBGene00006925; WP:CE04746; XI345 vit-1 K09F6.3 K09F6.3 K09F6.3; 2C551; CE31563; WBGene00019586; WP:CE31563 protein-tyrosine phosphatase K09H9.3 K09H9.3 col-49; K09H9.3; 1D705; CE18038; NM_058705; WBGene00000626; WP:CE18038 cuticular collagen K09H9.6 K09H9.6 lpd-6; K09H9.6; 1D714; CE37030; NM_058707; WBGene00003062; WP:CE37030 lpd-6 encodes a predicted rRNA-binding protein that is orthologous to Drosophila Peter Pan and the Saccharomyces cerevisiae SSF1 and SSF2 proteins that are required for ribosomal large subunit maturation; loss of lpd-6 activity via RNAi indicates that, in C. elegans, LPD-6 is required for fat storage and for larval growth and development; based upon its similarity to yeast SSF1 and SSF2, LPD-6 is predicted to be a nucleolar protein. K11C4.4 K11C4.4 odc-1; K11C4.4; 5H380; CE12114; DCOR_CAEEL; NM_072351; ODC/1; WBGene00003844; WP:CE12114 odc-1 encodes ornithine decarboxylase, the first enzyme of polyamine biosynthesis that catalyzes the conversion of ornithine to putrescine; ODC-1 is required for development when animals are deprived of exogenous polyamines, which are required for oogenesis and completion of embryogenesis; in addition,ODC-1 may contribute to male fertility; ODC-1 activity is detectable at all developmental stages, with highest levels observed in adults and L4 larvae. ornithine decarboxylase K11D12.3 K11D12.3 srr-4; K11D12.3; 5F503; CE30386; NM_071946; WBGene00005655; WP:CE30386 K11D12.4 K11D12.4 cpt-4; K11D12.4; 5F502; CE12132; WBGene00019644; WP:CE12132 acetyltransferase K11D2.2 K11D2.2 asah-1; dod-7; K11D2.2; 1N99; ASAH1_CAEEL; CE12120; NM_060772; WBGene00010769; WP:CE12120 K11D2.2 is orthologous to the human gene N-ACYLSPHINGOSINE AMIDOHYDROLASE (ASAH; OMIM:228000), which when mutated leads to Farber lipogranulomatosis. Human PHP32 protein like K11G12.1 K11G12.1 nas-11; K11G12.1; CE36313; CE37260; NAS11_CAEEL; WBGene00003530; WP:CE36313; WP:CE37260; XH333 K11H3.2 K11H3.2 K11H3.2; 3K933; CE00262; WBGene00010779; WP:CE00262; YM42_CAEEL K12D12.1 K12D12.1 K12D12.1; 2M169; CE06184; TOP2_CAEEL; WBGene00010785; WP:CE06184 DNA topoisomerase II M01E5.5 M01E5.5 top-1; M01E5.5; 1N889; CE12282; CE12284; NM_060936; TOPOI; WBGene00006595; WP:CE12282; WP:CE12284 top-1 encodes the C. elegans DNA topoisomerase I ortholog; TOP-1 exhibits DNA topoisomerase I activity in vitro and in vivo, this activity is required for normal gonad, germline, and embryonic development; top-1 mRNA is expressed throughout the gonad and during early embryogenesis, with mRNA levels nearly gone by hatching; TOP-1 protein levels are highest in embryos and L1 larvae, decrease by the L3 larval stage and then increase again during L4 and adult stages; in meiotic cells, oocytes, and early embryos, TOP-1 localizes to nuclei, while in later embryos TOP-1 is found in gut nucleoli; during cell division of 1-, 2-, and 4-cell embryos, TOP-1 also localizes to centrosomes. DNA topoisomerase I M02H5.B M02H5.B M05B5.2 M05B5.2 MYO2-B; M05B5.2; 1H748; CE31044; WBGene00010870; WP:CE31044 M05D6.1 M05D6.1 M05D6.1; 2I764; CE03499; WBGene00010874; WP:CE03499 serine/threonine kinase M110.1 M110.1 col-76; M110.1; 2I497; CE35898; NM_063325; WBGene00000652; WP:CE35898 collagen M110.5 M110.5 dab-1; M110.5; M110.5a.1; M110.5a.2; 2I519; CE36393; CE36446; CE37844; NM_063329; NM_063330; NM_063331; Q9U3A6_CAEEL; WBGene00000894; WP:CE36393; WP:CE36446; WP:CE37844 dab-1 encodes an ortholog of the cytoplasmic adaptor protein DISABLED, required for normal molting and meiotic arrest; DAB-1 is also required for EGL-17 secretion from vulval cells, and thus indirectly for normal sex myoblast (SM) migration and egg-laying; DAB-1 contains a conserved PTB domain and signals that confer localization to Golgi-proximal vesicles, and DAB-1 localizes to vesicular structures in vivo; dab-1 is expressed in ventral precursor cells, and DAB-1 prevents EGL-17 protein accumulation in them; dab-1 is also expressed in other cells (anchor cell, sheath cells, etc.) but has no obvious function in them; DAB-1 binds the cytoplasmic domains of either LRP-1 or LRP-2 in yeast two-hybrid experiments; dab-1(gk291) and dab-1(RNAi) animals have similar defects in molting, EGL-17 secretion from VPCs, SM migration, and egg-laying; dab-1(RNAi) does not enhance the SM phenotypes of lrp-1(RNAi) or lrp-2(RNAi), suggesting that these genes act in concert to promote normal EGL-17 secretion and SM migration; in vitro, DAB-1 binds to the ear domains of APT-4 (strongly) and of APT-1 and APT-9 (weakly); genetically, dab-1(RNAi) functions as part of the vab-1 pathway in oocytes inhibiting meiotic maturation, and DAB-1 is found in oocyte cytoplasm. M176.4 M176.4 M176.4; 2J711; CE33289; WBGene00010943; WP:CE33289 M195.1 M195.1 col-77; M195.1; 2I648; CE03514; NM_063358; WBGene00000653; WP:CE03514 cuticle collagen M60.2 M60.1 M60.2; M60.2.1; M60.2.2; CE28630; WBGene00019779; WP:CE28630; XI865 M60.4 M60.3 M60.4; M60.4b.1; M60.4b.2; M60.4b.3; M60.4b.4; CE02832; CE34063; WBGene00019780; WP:CE02832; WP:CE34063; XI852 M88.1 M88.1 ugt-62; M88.1; M88.1.1; M88.1.2; 3F628; CE01036; WBGene00010904; WP:CE01036 UDP-glucuronosyltransferase PDB1.1 PDB1.1 PDB1.1; CE31209; CE39603; CE39604; NM_076878; WBGene00019803; WP:CE31209; WP:CE39603; WP:CE39604; XI176 R02D5.7 R02D5.7 R02D5.7; 5O960; CE29435; WBGene00010980; WP:CE29435 R02F11.1 R02F11.1 R02F11.1; 5F281; CE12496; O16364_CAEEL; WBGene00019839; WP:CE12496 R04B5.9 R04B5.9 ugt-47; R04B5.9; 5K578; CE37984; WBGene00011006; WP:CE37984 UDP-glucuronosyltransferase R07B1.10 R07B1.10 lec-8; R07B1.10; R07B1.10.1; R07B1.10.2; CE26721; LEC8_CAEEL; NM_077248; WBGene00002271; WP:CE26721; XK469 galaptin domain R07E5.1 R07E5.1 R07E5.1; 3F501; CE00658; WBGene00011109; WP:CE00658 R07E5.15 R07E5.15 R07E5.15; 3F491; CE18126; WBGene00011120; WP:CE18126 R07E5.6 R07E5.6 R07E5.6; 3F489; CE18124; WBGene00011114; WP:CE18124 Coiled-coil protein R08C7.8 R08C7.8 R08C7.8; 4F198; CE07431; WBGene00019951; WP:CE07431 serine/threonine protein phosphatase R08F11.3 R08F11.3 cyp-33C8; R08F11.3; 5E272; CE12584; NM_071650; WBGene00019967; WP:CE12584 cytochrome P450 R09E10.6 R09E10.6 R09E10.6; 4L58; CE06288; WBGene00011176; WP:CE06288 R10D12.9 R10D12.9 R10D12.9; 5O435; CE12688; WBGene00011190; WP:CE12688 R10E9.2 R10E9.2 R10E9.2; 3F52; CE01051; WBGene00011214; WP:CE01051 R11A8.1 R11A8.1 R11A8.1; 4L120; CE06299; WBGene00011236; WP:CE06299 R11H6.4 R11H6.4 R11H6.4; 5P89; CE12776; WBGene00011252; WP:CE12776 R12E2.15 R12E2.15 R12E2.15; 1E716; CE18147; WBGene00020040; WP:CE18147 R13H9.1 R13H9.1 R13H9.1; 4F833; CE07447; WBGene00020070; WP:CE07447 R13H9.2 R13H9.2 msp-57; R13H9.2; 4F827; MSP55_CAEEL; NM_068312; WBGene00003450 msp-57 encodes a member of the major sperm protein family. major sperm protein (MSP-57) R13H9.4 R13H9.4 msp-53; R13H9.4; 4F828; NM_068313; WBGene00003446 msp-53 encodes a protein that belongs to a family of proteins called the Major Sperm Proteins (MSPs) that is conserved in nematodes; msp-53 has a C. briggsae homolog as identified by the Wobble Aware Bulk Aligner (WABA); the MSP family consists of closely related, small, basic proteins that make up 15% of sperm protein; this multigene family consists of over fifty genes, including many pseudogenes; MSPs are involved in both extracellular signaling and cytoskeletal functions during reproduction-MSP antagonizes Eph/ephrin signaling, in part, by binding VAB-1 Eph receptor tyrosine kinase on oocytes and sheath cells to promote oocyte maturation and MAPK activation; MSPs assemble into fibrous networks that drive movement of the C. elegans sperm; msp genes are expressed only in late primary spermatocytes. major sperm protein (MSP-53) R13H9.5 R13H9.5 R13H9.5; 4F830; CE07449; WBGene00020071; WP:CE07449 R13H9.6 R13H9.6 R13H9.6; 4F832; CE07450; WBGene00020072; WP:CE07450 R52.2 R52.2 R52.2; 2C417; CE12826; WBGene00020074; WP:CE12826 R57.1 R57.1 R57.1; R57.1b.1; R57.1b.2; R57.1c.1; R57.1c.2; R57.1c.3; CE12844; CE30114; CE37270; GCP2_CAEEL; WBGene00020082; WP:CE12844; WP:CE30114; WP:CE37270; XA925 trans-membrane protein R74.2 R74.2 R74.2; 3F279; CE23931; WBGene00011278; WP:CE23931 R74.3 R74.3 xbp-1; R74.3; R74.3.1; R74.3.2; 3F285; CE01056; WBGene00006959; WP:CE01056 xbp-1 encodes a bZIP transcription factor orthologous to yeast Hac1 and mammalian X box-binding protein 1 (XBP-1, OMIM:194355); XBP-1 is required for the unfolded protein response (UPR) that counteracts cellular stress induced by accumulation of unfolded proteins in the endoplasmic reticulum (ER); XBP-1 mRNA is spliced by the IRE-1 endoribonuclease to promote translation of transcriptionally active XBP-1 that positively regulates UPR gene expression to maintain ER homeostasis and promote normal development. X box DNA binding protein-1 T01B10.2 T01B10.2 grd-14; T01B10.2; CE07456; NM_077040; WBGene00001703; WP:CE07456; XJ117 grd-14 encodes a hedgehog-like protein, with an N-terminal signal sequence and a C-terminal Ground domain; the Ground domain is predicted to form a cysteine-crosslinked protein involved in intercellular signalling, and it has subtle similarity to the N-terminal Hedge domain of HEDGEHOG proteins; GRD-14 is required for normal growth to full size, locomotion, and vulval morphogenesis; all of these requirements may reflect common defects in cholesterol-dependent hedgehog-like signalling or in vesicle trafficking. T01B11.4 T01B11.4 tag-316; T01B11.4; 4J224; CE12898; WBGene00020140; WP:CE12898 ADP/ATP translocase T01B7.7 T01B7.7 rol-6; T01B7.7; 2J23; CE03591; NM_063457; ROL6_CAEEL; WBGene00004397; WP:CE03591 The rol-6 gene encodes a cuticle collagen related to human collagen alpha 1 (III) chain precursor (OMIM:120180), and is required for normal cuticular morphology; ROL-6 interacts with SQT-1, a closely related cuticle collagen, and is expressed at all stages from L2 to adult with transcripts detected at each of the molts preceding these stages. cuticle collagen ROL-6 T01D1.6 T01D1.6 abu-11; pqn-61; T01D1.6; 2A484; CE28071; NM_061278; P91419_CAEEL; WBGene00000034; WP:CE28071 abu-11 encodes a transmembrane protein with a predicted signal sequence, a glutamine/asparagine-rich domain and multiple cysteine-rich repeats (DUF139); abu-11 expression is induced by blockage of the unfolded-protein response in the endoplasmic reticulum, and ABU-11 may help protect the organism from damage by improperly folded nascent protein. T01G6.7 T01G6.7 nhr-55; T01G6.7; 5A957; CE37786; NHR55_CAEEL; NM_070814; WBGene00003645; WP:CE37786 nhr-55 encodes a member of the superfamily of nuclear receptors, which is one of the most abundant class of transcriptional regulators; nuclear receptors have a well conserved DNA binding domain and a less conserved C-terminal ligand binding domain. zinc finger protein T02E1.6 T02E1.6 T02E1.6; 1I789; CE38218; WBGene00011378; WP:CE38218 T02E9.2 T02E9.2 grl-7; T02E9.2; T02E9.2a.1; T02E9.2a.2; 5L826; CE13064; CE38539; NM_073481; O18015_CAEEL; WBGene00001716; WP:CE13064; WP:CE38539 grl-7 encodes a hedgehog-like protein, with an N-terminal signal sequence, a central low-complexity region, and a C-terminal Ground-like (Grl) domain; GRL-7 is expressed in intestine, hypodermis, and seam cells; the Grl domain is predicted to form a cysteine-crosslinked protein involved in intercellular signalling, and it has subtle similarity to the N-terminal Hedge domain of HEDGEHOG proteins. T02G5.8 T02G5.8 kat-1; T02G5.8; 2H367; CE29990; NM_063054; WBGene00002183; WP:CE29990 kat-1 encodes a homolog of the human gene ACAT1, which when mutated leads to alpha-methylacetoaceticaciduria (OMIM:203750). acetoacetyl-C0A thiolase T03D3.4 T03D3.4 srh-36; T03D3.4; 5D296; CE25098; NM_071363; WBGene00005259; WP:CE25098 7TM chemoreceptor, srh family T03F6.3 T03F6.3 T03F6.3; 3O479; CE16337; GNPI_CAEEL; WBGene00011399; WP:CE16337 Glucosamine-6-phosphate isomerase T04C9.4 T04C9.5 mlp-1; T04C9.4; 3H62; CE31589; CE31590; CE31591; NM_065899; NM_065900; NM_065901; WBGene00003375; WP:CE31589; WP:CE31590; WP:CE31591 contains LIM-like binding domain T04D3.5 T04D3.5 T04D3.5; 1N922; CE13161; WBGene00011434; WP:CE13161 T05A10.3 T05A10.3 T05A10.3; CE03635; WBGene00011460; WP:CE03635; XL407 Transthyretin-like family T05A10.5 T05A10.5 T05A10.5; CE13189; WBGene00011462; WP:CE13189; XL408 testes-specific protein like T05C12.1 T05C12.1 T05C12.1; 2I461; CE02312; WBGene00011466; WP:CE02312 serine/threonine kinase T05C12.10 T05C12.10 qua-1; T05C12.10; 2I493; CE34989; M110; NM_063324; WBGene00004264; WP:CE34989 qua-1 encodes a hedgehog-like protein, with (from N- to C-terminus) a signal sequence, a Qua domain, a 5W repeat, an extended region of low-complexity sequence, and a Hint/Hog domain; QUA-1 is conserved among nematodes from Caenorhabditis to Brugia; QUA-1 is expressed prior to molting in hyp1 to hyp11 hypodermal cells, but not in seam cells, and ceases to be expressed after each molting cycle or in gravid adults no longer molting; QUA-1 is strongly required for normal molting, with lethal molting defects in qua-1 mutants and severe defects in qua-1(RNAi) animals; similar molting defects in RNAi of ptr-4 and ptr-23 (encoding Dispatched homologs) suggest that PTR-4 and PTR-23 may export QUA-1 from hypodermal cells synthesizing it; other sites of QUA-1 expression include intestinal and rectal cells, excretory duct and pore cells, sensilla support cells, the P cell lineage in L1, body wall muscle, and the adult reproductive system; QUA-1 is also required for normal adult alae formation, growth to full size, cuticle adhesion, locomotion, and male tail development; the Hint/Hog domain is predicted to cut QUA-1 into two halves and then covalently link cholesterol to the C-terminus of the Qua domain; the Qua domain is predicted to form a cysteine-crosslinked protein involved in intercellular signalling, and the Qua domain has subtle similarity to the N-terminal Hedge domain of HEDGEHOG proteins; both Qua and Hint/Hog domains are required for transgenic rescue of a lethal qua-1 allele; defects in both qua-1 mutants and qua-1(RNAi) animals; all of QUA-1's functions may reflect common defects in cholesterol-dependent hedgehog-like signalling. hedgehog-like protein T05F1.8 T05F1.8 T05F1.8; 1K219; CE13249; WBGene00011493; WP:CE13249 mitochondrial phosphate carrier protein T05G5.6 T05G5.6 ech-6; T05G5.6; T05G5.6.1; T05G5.6.2; 3K842; CE00318; ECHM_CAEEL; NM_066755; WBGene00001155; WP:CE00318 Enoyl-CoA hydratase T05H4.5 T05H4.5 T05H4.5; T05H4.5.1; T05H4.5.2; 5G917; CE13277; WBGene00020268; WP:CE13277 The T05H4.5 gene encodes an ortholog of the human gene NADH-CYTOCHROME B5 REDUCTASE (DIA1), which when mutated leads to methemoglobinemia (OMIM:250800). NADH-cytochrome B5 reductase T06C10.3 T06C10.3 T06C10.3; 4I637; CE04901; WBGene00020289; WP:CE04901 T06C10.6 T06C10.6 kin-26; T06C10.6; 4I640; CE04904; NM_068908; WBGene00002208; WP:CE04904 tyosine-protein kinase T06E4.8 T06E4.8 T06E4.8; 5K102; CE23951; WBGene00011535; WP:CE23951 T08A9.7 T08A9.7 spp-3; T08A9.7; T08A9.7.1; T08A9.7.2; CE31233; NM_076834; WBGene00004988; WP:CE31233; XH934 7TM chemoreceptor, spp family T09B4.7 T09B4.7 T09B4.7; 1G734; CE13469; WBGene00020381; WP:CE13469 T10C6.11 T10C6.11 his-4; T10C6.11; 5Q520; CE16386; NM_074630; WBGene00001878; WP:CE16386 his-4 encodes an H2B histone. histone H2B T10C6.12 T10C6.12 his-3; T10C6.12; 5Q521; CE04501; NM_074631; WBGene00001877; WP:CE04501 his-3 encodes an H2A histone; by homology, HIS-3 is predicted to function as a nucleosome component required for packaging of DNA into chromatin; his-3 is a replication-dependent histone locus that resides in the HIS1 cluster on chromosome V. histone H2A T10E10.1 T10E10.1 col-168; T10E10.1; CE23970; NM_076659; WBGene00000741; WP:CE23970; XG945 collagen T10H4.12 T10H4.12 cpr-3; T10H4.12; 5P778; CE27590; CPR3_CAEEL; NM_074389; WBGene00000783; WP:CE27590 cathepsin protease T11B7.3 T11B7.3 col-118; T11B7.3; 4J613; CE03649; NM_069131; WBGene00000692; WP:CE03649 cuticle collagen T12B5.10 T12B5.10 fbxa-60; T12B5.10; 3B560; CE20067; WBGene00020456; WP:CE20067 This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins; this gene's encoded protein also contains an FTH/DUF38 motif, which may also mediate protein-protein interaction. T12G3.1 T12G3.1 T12G3.1; T12G3.1.1; T12G3.1.2; 4M801; CE37554; Q22436_CAEEL; WBGene00011737; WP:CE37554 Drosphila REF (2)P like T13F2.11 T13F2.11 msp-78; T13F2.11; 4K535; CE13638; MSP78_CAEEL; NM_069341; WBGene00003465; WP:CE13638 msp-78 encodes a protein that belongs to a family of proteins called the Major Sperm Proteins (MSPs) that is conserved in nematodes; this family consists of closely related, small, basic proteins that make up 15% of sperm protein; this multigene family consists of over fifty genes, including many pseudogenes; MSPs are involved in both extracellular signaling and cytoskeletal functions during reproduction-MSP antagonizes Eph/ephrin signaling, in part, by binding VAB-1 Eph receptor tyrosine kinase on oocytes and sheath cells to promote oocyte maturation and MAPK activation; MSPs assemble into fibrous networks that drive movement of the C. elegans sperm; msp genes are expressed only in late primary spermatocytes. major sperm protein T13F2.9 T13F2.9 T13F2.9; 4K533; CE13635; WBGene00011748; WP:CE13635 T14B4.4 T14B4.4 tsp-10; T14B4.4; T14B4.4b.1; T14B4.4b.2; 2H9; CE02047; CE39776; NM_062968; WBGene00006636; WP:CE02047; WP:CE39776 transpanin T14B4.6 T14B4.6 dpy-2; rol-2; T14B4.6; 2H5; CE04953; DPY2_CAEEL; NM_062966; WBGene00001064; WP:CE04953 The dpy-2 gene encodes an unusual cuticular collagen that is required for maintaining the normal body length of the animal in later larval stages; dpy-2 interacts with other cuticular collagens such as dpy-10 and sqt-1, and suppresses mutations in glp-1, mup-1, and emb-5. T14G10.8 T14G10.8 T14G10.8; CE06454; WBGene00011777; WP:CE06454 T15B7.2 T15B7.2 T15B7.2; T15B7.2.1; T15B7.2.2; 5H319; CE33319; WBGene00020517; WP:CE33319 T15H9.5 T15H9.5 T15H9.5; 2J900; CE01668; WBGene00011790; WP:CE01668; YRY5_CAEEL T16A9.5 T16A9.5 T16A9.5; 5O694; CE13728; WBGene00011795; WP:CE13728 T16H12.6 T16H12.6 kel-10; T16H12.6; 3L188; CE36451; KEL10_CAEEL; NM_066840; WBGene00002186; WP:CE36451 MIPP repeats T18H9.1 T18H9.1 grd-6; T18H9.1; 5J705; CE35772; NM_072988; WBGene00001695; WP:CE35772 grd-6 encodes a hedgehog-like protein, with an N-terminal signal sequence, a central low-complexity proline-rich domain, and a C-terminal Ground domain; GRD-6 is expressed in hypodermis and in various neurons, in both head and tail, and the PVT interneuron; the Ground domain is predicted to form a cysteine-crosslinked protein involved in intercellular signalling, and it has subtle similarity to the N-terminal Hedge domain of HEDGEHOG proteins; GRD-6 has no obvious function in RNAi assays. T19B10.2 T19B10.2 phi-59; T19B10.2; T19B10.2.1; T19B10.2.2; 5L703; CE16413; WBGene00011831; WP:CE16413 T19D12.4 T19D12.4 T19D12.4; 2G925; CE17238; CE39409; WBGene00020579; WP:CE17238; WP:CE39409 T20B6.3 T20B6.3 T20B6.3; 3D984; CE13778; WBGene00020599; WP:CE13778 T20D3.2 T20D3.2 T20D3.2; T20D3.2.1; T20D3.2.2; 4K94; CE03671; WBGene00011856; WP:CE03671 T21D12.2 T21D12.2 col-100; dpy-9; T21D12.2; 4B12; CE35021; NM_067488; WBGene00001071; WP:CE35021 dpy-9 encodes a cuticular collagen family member with similarity to human collagen alpha 5, type IV, and affects body length. cuticular collagen T21G5.4 T21G5.4 T21G5.4; 1H448; CE13894; WBGene00020661; WP:CE13894 T21H3.1 T21H3.1 T21H3.1; 5B657; CE13898; CE38551; WBGene00020662; WP:CE13898; WP:CE38551 T22B3.3 T22B3.3 T22B3.3; 4M466; CE03695; WBGene00011911; WP:CE03695 T22C1.8 T22C1.8 T22C1.8; 1I532; CE18278; WBGene00011918; WP:CE18278 tyrosine specific protein phosphatase T22D1.3 T22D1.3 T22D1.3; T22D1.3b.1; T22D1.3b.2; 4H681; CE30188; CE33940; WBGene00020682; WP:CE30188; WP:CE33940 inosine monophosphate dehydrogenase T23B3.5 T23B3.5 T23B3.5; 1H282; CE14016; WBGene00020713; WP:CE14016 T23F11.2 T23F11.2 T23F11.2; 3F744; CE01095; WBGene00011954; WP:CE01095 T23F6.4 T23F6.4 rbd-1; T23F6.4; T23F6.4.1; T23F6.4.2; 4N493; CE18963; NM_070031; WBGene00004315; WP:CE18963 RNA recognition motif. (aka RRM, RBD, or RNP domain) (6 domains) T25B9.6 T25B9.6 T25B9.6; 4L523; CE35628; WBGene00012012; WP:CE35628 T25B9.9 T25B9.9 T25B9.9; T25B9.9.1; T25B9.9.2; 4L541; 6PGD_CAEEL; CE06508; WBGene00012015; WP:CE06508 6-phosphogluconate dehydrogenase T25C8.3 T25C8.3 gln-4; T25C8.3; 3O688; NM_067407; WBGene00001605 T25E4.1 T25E4.1 T25E4.1; 2F869; CE28493; WBGene00020803; WP:CE28493; YR01_CAEEL T26A5.9 T26A5.9 dlc-1; T26A5.9; T26A5.9.1; T26A5.9.2; 3H554; CE00788; DYL1_CAEEL; NM_066021; WBGene00001005; WP:CE00788 dlc-1 encodes a dynein light chain type 1 that affects pronuclear migrations and thus affects embryonic viability; also affects fertility, body wall morphology and integrity. T27A10.4 T27A10.4 T27A10.6 T27A10.6 T27A10.6; T27A10.6.1; T27A10.6.2; CE30193; WBGene00020846; WP:CE30193; XE208 T27A3.3 T27A3.3 ssp-16; T27A3.3; 1G679; CE14221; NM_059361; SSP16_CAEEL; WBGene00006044; WP:CE14221 T27A3.4 T27A3.4 T27A3.4; 1G675; CE14223; WBGene00020840; WP:CE14223 T27A3.5 T27A3.5 T27A3.5; 1G676; CE34379; WBGene00020841; WP:CE34379 T27E4.7 T27E4.7 T27E4.7; T27E4.7.1; T27E4.7.2; 5J556; CE14259; WBGene00020865; WP:CE14259 T27E7.1 T27E7.1 T27E7.1; 4P285; CE16505; WBGene00012087; WP:CE16505 T28B4.3 T28B4.3 T28B4.3; CE14325; WBGene00020886; WP:CE14325; XH214 T28C6.4 T28C6.4 T28C6.4; 4J588; NM_069125; WBGene00000691 cuticle collagen T28H11.1 T28H11.1 ssq-4; T28H11.1; 4F781; CE30698; NM_068303; WBGene00006053; WP:CE30698 T28H11.5 T28H11.5 ssq-2; T28H11.5; 4F761; CE14377; NM_068297; WBGene00006051; WP:CE14377 T28H11.6 T28H11.6 ssp-11; T28H11.6; T28H11.6.1; T28H11.6.2; 4F764; NM_068298; SSP9_CAEEL; WBGene00006040 T28H11.7 T28H11.7 T28H11.7; 4F780; CE14380; WBGene00020905; WP:CE14380 VW02B12L.1 VW02B12L.1 vha-6; VW02B12L.1; VW02B12L.1.1; VW02B12L.1.2; 2L726; CE18980; NM_064035; WBGene00006915; WP:CE18980 vha-6 encodes an ortholog of subunit a of the membrane-bound (V0) domain of vacuolar proton-translocating ATPase (V-ATPase); VHA-6 is orthologous to human ATP6N1A (OMIM:192130), ATP6V0A2, ATP6V0A4 (OMIM:605239, mutated in distal renal tubular acidosis), and TCIRG1 (OMIM:604592, mutated in osteopetrosis); VHA-6 is expressed in germline (P2 through Z3 cells until the comma stage), on the apical surface of postembryonic intestinal cells, and at the junction between pharynx and intestine; VHA-6 is required for growth and survival past the L1 larval stage; vha-6(RNAi) animals arrest as L1 larvae and remain alive (but do not grow) for one week; in S. cerevisiae, different V0 a-subunits (Stv1p and Vph1p) direct the assembly of V-ATPases to different membranes and organelles, suggesting that the profusion of such subunits in C. elegans (co-orthologous VHA-5, VHA-6, VHA-7, and six UNC-32 isoforms) may have a similar function; VHA-6 is predicted to capture protons from V-ATPase transmembrane rotor components and export the protons across the membrane. vacuolar ATP synthase VZK822L.1 VZK822L.1 fat-6; VZK822L.1; 4M678; CE18302; NM_069854; WBGene00001398; WP:CE18302 fat-6 encodes a delta-9 fatty acid desaturase that is predicted to be mitochondrial. acyl-CoA desaturase W01B6.2 W01B6.2 W01B6.2; 4K838; CE03754; WBGene00012169; WP:CE03754 serine/threonine kinase W01B6.6 W01B6.6 W01B6.6; 4K845; CE03758; WBGene00012173; WP:CE03758 tyrosine phosphatase W01C9.4 W01C9.4 W01C9.4; 2I837; CE02370; WBGene00012177; WP:CE02370; YWC4_CAEEL 2,4-dienoyl-CoA reductase W01F3.2 W01F3.2 W01F3.2; 5V131; CE16530; WBGene00012185; WP:CE16530 W03B1.1 W03B1.1 W03B1.1; 4F99; CE14488; WBGene00020971; WP:CE14488 W03D8.10 W03D8.10 W03D8.10; 1D355; CE18330; WBGene00020991; WP:CE18330 W03D8.5 W03D8.5 W03D8.5; 1D385; CE37996; WBGene00020987; WP:CE37996 W03D8.9 W03D8.9 W03D8.9; 1D354; CE26983; WBGene00020990; WP:CE26983 W03F8.2 W03F8.2 W03F8.2; 4F957; CE35040; WBGene00020992; WP:CE35040 protein kinase W03G1.2 W03G1.2 W03G1.2; 4B279; CE17280; WBGene00021010; WP:CE17280 W04E12.4 W04E12.4 W04E12.4; 5U213; CE34100; WBGene00012249; WP:CE34100 W05G11.3 W05G11.3 col-88; W05G11.3; W05G11.3.1; W05G11.3.2; 3A659; CE14628; NM_064730; WBGene00000663; WP:CE14628 cuticular collagen W06A7.5 W06A7.5 nspa-8; W06A7.5; 5P306; CE14672; NM_074253; WBGene00012294; WP:CE14672 W06B3.2 W06B3.2 sma-5; W06B3.2; CE31629; CE31630; CE38984; CE39526; NM_171782; NM_171783; WBGene00004859; WP:CE31629; WP:CE31630; WP:CE38984; WP:CE39526; XM616 sma-5 encodes a serine/threonine kinase homologous to the mammalian MAP kinase MAPK7/ERK5 (OMIM:602521, required for development of extraembryonic vasculature and embryonic cardiovasculature); SMA-5 is required for normal body size morphogenesis, growth rates, and intestinal granule distribution, and for regulating the size of the intestine, body wall muscle, and hypodermis, as well as the number of intestinal nuclei; SMA-5 is expressed in the intestine and in hypodermal seam cells. W06D4.2 W06D4.2 W06D4.2; 1J633; CE16544; WBGene00012296; WP:CE16544 W07B8.1 W07B8.1 W07B8.1; 5B617; CE14674; WBGene00021070; WP:CE14674 thiol protease W07G4.5 W07G4.5 W07G4.5; 5N529; CE03793; Q27408_CAEEL; WBGene00012339; WP:CE03793 W08A12.2 W08A12.2 W08A12.2; 5E164; CE14698; WBGene00021079; WP:CE14698 W08D2.4 W08D2.4 fat-3; W08D2.4; 4K569; CE25153; NM_069351; Q23221_CAEEL; WBGene00001395; WP:CE25153 The fat-3 gene encodes a delta-6 fatty acid desaturase ('linoleoyl-CoA desaturase') containing an N-terminal cytochrome b5 domain; FAT-3 expressed in yeast uses linoleic and alpha-linolenic acid as substrates; FAT-3 is absolutely required in vivo for synthesis of delta-6 fatty acids, and also required for fully normal synthesis of C20 fatty acids; FAT-3 is required for a normally fast growth rate and movement speed, and for normal defecation rhythms and fertility. W08E12.5 W08E12.G W08E12.5; 4E65; WBGene00021086 W08E12.1 W08E12.K W08E12.1; 4E77; CE21280; WBGene00021082; WP:CE21280 W08E3.1 W08E3.1 snr-2; W08E3.1; W08E3.1.1; W08E3.1.2; 1N931; CE14704; NM_060947; RSMB_CAEEL; WBGene00004915; WP:CE14704 small nuclear ribonucleoprotein (SNRNP) W09C3.6 W09C3.6 gsp-3; W09C3.6; 1F278; CE14754; NM_059028; WBGene00021113; WP:CE14754 serine/threonine protein phosphatase PP1 W09C3.8 W09C3.8 W09C3.8; 1F284; CE39115; WBGene00021115; WP:CE39115 W09G12.7 W09G12.7 W09G12.7; 4B983; CE18346; O45198_CAEEL; WBGene00021121; WP:CE18346 W10C8.5 W10C8.5 W10C8.5; W10C8.5.1; W10C8.5.2; W10C8.5.3; 1D422; CE18353; WBGene00021128; WP:CE18353 ATP transferase Y106G6A.2 Y106G6A.3 Y106G6A.2; 1K508; CE30567; WBGene00013695; WP:CE30567 Y106G6A.4 Y106G6A.4 Y106G6A.4; 1K509; CE30569; WBGene00013696; WP:CE30569 Y106G6E.3 Y106G6E.3 Y106G6E.3; 1K795; CE20407; WBGene00013707; WP:CE20407 Y110A7A.9 Y110A7A. Y110A7A.9; Y110A7A.9b.1; Y110A7A.9b.2; 1F691; CE28105; CE37057; WBGene00022459; WP:CE28105; WP:CE37057 Y110A7A.9 is orthologous to the human gene KIAA1351 PROTEIN (WDR11; OMIM:606417), which when mutated leads to disease. Y113G7C.1 Y113G7C.1 Y113G7C.1; Y113G7C.B; 5U793; CE23304; WBGene00013771; WP:CE23304 Protein-tyrosine phosphatase Y116A8C.38 Y116A8C.38 Y116A8C.38; 4S77; CE33848; WBGene00013811; WP:CE33848 Y43F8C.5 Y116F11A.ZZ1 Y43F8C.5; 5U106; CE21903; WBGene00012827; WP:CE21903 Y11D7A.11 Y11D7A.11 col-120; Y11D7A.11; 4K26; CE20194; NM_069216; Q9XWR2_CAEEL; WBGene00000694; WP:CE20194 Y11D7A.15 Y11D7A.15 Y11D7A.15; WBGene00012438 Y13C8A.B Y13C8A.B Y15E3A.5 Y15E3B.F Y15E3A.5; CE31634; Q8MPS4_CAEEL; WBGene00012444; WP:CE31634; XP963 Y19D10A.J Y19D10A.J Y22F5A.4 Y22F5A.4 lys-1; Y22F5A.4; Y22F5A.4.1; Y22F5A.4.2; 5K759; CE16605; NM_073241; O62415_CAEEL; WBGene00003090; WP:CE16605 F55F10.1 Y24D9A.E, Y24D9A.F F55F10.1; Y24D9A.F; 4F151; CE30377; WBGene00018898; WP:CE30377 F55F10.1 Y24D9A.E, Y24D9A.F F55F10.1; Y24D9A.F; 4F151; CE30377; WBGene00018898; WP:CE30377 Y24F12A.C Y24F12A.C Y25C1A.1 Y25C1A.1 Y25C1A.1; Y25C1A.O; 2D405; CE21468; WBGene00021288; WP:CE21468 Y27F2A.3 Y27F2A.H sri-40; Y27F2A.3; 2D463; CE33728; CE37166; WBGene00005552; WP:CE33728; WP:CE37166 7TM chemoreceptor, sri family Y37D8A.12 Y37D8A.12 Y37D8A.12; Y37D8A.12a.1; Y37D8A.12a.2; 3N969; CE20216; CE28421; WBGene00012552; WP:CE20216; WP:CE28421 Y37D8A.13 Y37D8A.13 adm-1; max-3; unc-71; Y37D8A.13; 3N972; CE20217; NM_067279; WBGene00006804; WP:CE20217 unc-71 encodes an ADAM, a disintegrin and metalloprotease-containing transmembrane protein that is a member of the metzincin superfamily of proteases; UNC-71 is required non-cell autonomously for motor axon guidance and sex myoblast migration; UNC-71 does not appear to have an active metalloprotease domain, but functions with UNC-6/netrin and integrins INA-1/PAT-3 to provide guidance cues during axonal migration; UNC-71 is expressed in a restricted pattern in the excretory and excretory gland cells, some head neurons, the sphincter muscles, and hypodermal cells surrounding the vulva. Disintegrin Y37D8A.19 Y37D8A.19 Y37D8A.19; Y37D8A.19.1; Y37D8A.19.2; 3O19; CE20223; WBGene00012557; WP:CE20223 Y37E11B.10 Y37E11B.10 Y37E11B.10; 4E368; CE28114; CE33857; CE33858; WBGene00021381; WP:CE28114; WP:CE33857; WP:CE33858 W06H8.8 Y38B5A.B tag-211; tag-58; tag-7; ttn-1; W06H8.8; Y38B5A.A; 5G672; CE31088; CE36722; CE36723; CE36724; CE36725; CE36726; CE36727; WBGene00006436; WBGene00021069; WP:CE31088; WP:CE36722; WP:CE36723; WP:CE36724; WP:CE36725; WP:CE36726; WP:CE36727 Y38C1BA.3 Y38C1BA.A col-109; Y38C1BA.3; Y38C1BA.A; 4C582; CE21569; NM_067737; WBGene00000683; WP:CE21569 collagen Y38H8A.3 Y38H8A.3 Y38H8A.3; 4O239; CE18365; WBGene00012637; WP:CE18365 serine/threonine kinase Y39A1A.2 Y39A1A.2 Y39A1A.2; 3L690; CE37800; WBGene00012642; WP:CE37800 Y39E4A.1 Y39E4A.1 Y39E4A.1; 3O41; CE16615; WBGene00012711; WP:CE16615 Y39G10A_237.B Y39G10A_237.B Y41E3.2 Y41E3.2 col-134; dpy-4; Y41E3.2; 4P750; CE18370; NM_070407; WBGene00001066; WP:CE18370 dpy-4 encodes a cuticle collagen; dpy-4 activity is required for normal body morphology, locomotion, and larval development. CUTICLE COLLAGEN 1 Y43C5A.1 Y43C5A.1 Y43C5A.1; 4L34; CE19150; WBGene00012781; WP:CE19150 Y43F8A.2 Y43F8A.2 Y43F8A.2; Y43F8A.B; 5T849; CE24284; WBGene00012809; WP:CE24284 Y43F8C.1 Y43F8C.1 nlp-25; Y43F8C.1; 5U81; CE21899; NM_075400; Q9XWP3_CAEEL; WBGene00003763; WP:CE21899 Y46C8AL.1 Y46C8_100.D clec-73; Y46C8AL.1; 4E720; CE21962; Q9N3W2_CAEEL; WBGene00021579; WP:CE21962 Y46G5A.14 Y46G5.O Y46G5A.14; 2N65; CE21989; WBGene00012905; WP:CE21989 Y46H3C.C Y46H3C.C Y46H3C_14.C Y46H3C_14.C Y46H3C.4 Y46H3C_14.D Y46H3C.4; 5C159; CE24315; WBGene00021604; WP:CE24315 Y47D3A.31 Y47D3A.F Y47D3A.31; 3M246; CE22031; WBGene00012937; WP:CE22031 Y48B6A.8 Y48B6A.8 ace-3; Y48B6A.8; 2O499; CE28131; NM_064562; WBGene00000037; WP:CE28131 ace-3 encodes one of four C. elegans acetylcholinesterases (AChE); ACE-3 represents ~5% of the total AChE activity in C. elegans and in vitro, hydrolyzes acetylthio-, butyrylthio-, and propionylthiocholine substrates with equal efficiency; although loss-of-function mutations in ace-3 result in no obvious defects, animals doubly mutant with ace-1 or ace-2 have slight defects in backward locomotion and animals triply mutant for ace-1, -2, and -3 arrest as unhatched, yet fully developed, embryos; ace-3 is the downstream gene in an operon with a fourth AChE-encoding gene, ace-4, and transcriptional reporter fusions with ace-4 upstream sequences direct expression in pharyngeal muscles pm3, 4, 5, and 7, the two CAN (canal associated neuron) cells, midbody dorsal body wall muscles in larvae, and several neurons in the head and anal ganglion Y49E10.6 Y49E10.6 his-72; Y49E10.6; Y49E10.6.1; Y49E10.6.2; Y49E10.A; 3N456; CE22223; H332_CAEEL; NM_067207; WBGene00001946; WP:CE22223 his-72 encodes an H3 histone required for embryonic viability. Core histone H2A/H2B/H3/H4 Y49E10.8 Y49E10.8 Y49E10.8; 3N477; WBGene00014903 Y49F6B.10 Y49F6B.P col-71; Y49F6B.10; 2D790; CE25334; NM_062161; WBGene00000647; WP:CE25334 Y51A2B.1 Y51A2B.1 Y51A2B.1; 5S847; CE16655; WBGene00013065; WP:CE16655 Y53C10A.2 Y53C10A.2 Y53C10A.2; 1M560; CE22370; WBGene00013133; WP:CE22370 Y54E2A.7 Y54E2A.7 Y54E2A.7; 2P58; CE20306; WBGene00013192; WP:CE20306 Y54E2A.9 Y54E2A.9 Y54E2A.9; 2P68; CE20308; WBGene00013194; WP:CE20308 Y54E5A.1 Y54E5A.1 Y54E5A.1; 1P280; CE28791; Q9XWK1_CAEEL; WBGene00013197; WP:CE28791 Y57G11A.2 Y57G11A.2 Y57G11A.2; 4P282; CE16664; WBGene00013290; WP:CE16664 Y57G11C.5 Y57G11C.5 Y57G11C.5; 4P520; CE37440; WBGene00013303; WP:CE37440 Y57G7A.6 Y57G7A.6 Y57G7A.6; 2B572; CE19635; WBGene00021969; WP:CE19635 Y59E9AL.3 Y59E9_118.A Y59E9AL.3; 4F985; CE22659; WBGene00021993; WP:CE22659 Y59E9_118.E Y59E9_118.E Y59E9_120.C Y59E9_120.C Y5F2A.1 Y5F2A.1 Y5F2A.1; Y5F2A.1.1; Y5F2A.1.2; 4L828; CE19022; UP04_CAEEL; WBGene00012382; WP:CE19022 Transthyretin-like family Y61A9LA.8 Y61A9LA_68.A Y61A9LA.8; 5F42; CE31123; WBGene00022019; WP:CE31123 Y65B4BL.5 Y65B4B_9.B Y65B4BL.5; Y65B4BL.B; 1A982; CE24550; WBGene00022037; WP:CE24550 Y66H1A.5 Y66H1A.5 Y66H1A.5; 4B180; CE22756; WBGene00022047; WP:CE22756 Y67A6A.1 Y67A6A.1 Y67A6A.1; 1K406; CE20349; WBGene00013449; WP:CE20349 Y69E1A.1 Y69E1A.1 Y69E1A.1; 4L712; CE22808; WBGene00013473; WP:CE22808 Y69E1A.2 Y69E1A.2 Y69E1A.2; 4L715; CE22809; WBGene00013474; WP:CE22809 Y69H2.3 Y69H2.3 Y69H2.3; Y69H2.3a.1; Y69H2.3a.2; Y69H2.3d.1; Y69H2.3d.2; 5T136; CE32543; CE32544; CE32545; CE32546; Q9U1T5_CAEEL; WBGene00013481; WP:CE32543; WP:CE32544; WP:CE32545; WP:CE32546 Y71H10A.2 Y71H10A.2 Y71H10A.2; Y71H10A.2.1; Y71H10A.2.2; Y71H10A.2.3; Y71H10A.2.4; Y71H10A.2.5; CE20354; Q9TZL9_CAEEL; WBGene00022200; WP:CE20354; XD555 Y73F4A.1 Y73F4A.1 Y73F4A.1; 4J808; CE20367; DMON2_CAEEL; WBGene00013514; WP:CE20367 Y73F8A.8 Y73F8A.G pqn-90; Y73F8A.8; 4Q56; CE22977; NM_070442; WBGene00004170; WP:CE22977 The protein product of this gene is predicted to contain a glutamine/asparagine (Q/N)-rich ('prion') domain, by the algorithm of Michelitsch and Weissman (as of the WS77 release of WormBase, i.e., in wormpep77). Y73F8A.12 Y73F8A.K Y73F8A.12; 4Q76; CE25590; WBGene00013521; WP:CE25590 Y39G10AR.6 Y74C10A_154.A ugt-31; Y39G10AR.6; 1C907; CE33221; WBGene00021464; WP:CE33221 7TM chemoreceptor, ugt family Y75B12B.2 Y75B12B.2 cyn-7; cyp-7; Y75B12B.2; Y75B12B.2.1; Y75B12B.2.2; Y75B12B.2.3; 5P666; CE20371; CYP7_CAEEL; NM_074348; WBGene00000883; WP:CE20371 cyp-7 encodes a cyclophilin A isoform; while not tested peptidyl-prolyl isomerase activity in vitro, it is very similar to CYP-3 and closely resembles the prototypical CypA, and is therefore likely to be a member of the cytosolic CsA-binding cyclophilin subfamily; CYP-7 was required for embryonic viability in one set of mass RNAi assays. Peptidyl-prolyl cis-trans isomerases Y75B8A.23 Y75B8A.23 Y75B8A.23; Y75B8A.Z; 3N339; CE23034; WBGene00013556; WP:CE23034 Y76A2A.1 Y76A2A.1 tag-164; Y76A2A.1; 3O549; CE19270; WBGene00006509; WP:CE19270 Y76A2C.A Y76A2C.A Y9D1A.1 Y9D1A.1 Y9D1A.1; Y9D1A.C; 2H739; CE39996; WBGene00021186; WP:CE39996 ZC116.2 ZC116.2 ZC116.2; 5N92; CE06565; CYC2_CAEEL; WBGene00013854; WP:CE06565 cytochrome c ZC168.6 ZC168.6 ZC168.6; 4L504; CE06572; SSPZC_CAEEL; WBGene00013858; WP:CE06572 ZC204.12 ZC204.12 ZC204.12; 2B946; CE15106; WBGene00022562; WP:CE15106 ZC250.1 ZC250.1 cyn-17; cyp-17; ZC250.1; 5G285; CE37686; NM_072121; WBGene00000893; WP:CE37686 ZC373.7 ZC373.7 col-176; ZC373.7; CE02380; NM_077291; WBGene00000749; WP:CE02380; XK697 cuticular collagen ZC376.8 ZC376.8 ZC376.8; 5O661; CE38013; WBGene00013879; WP:CE38013 ZC477.1 ZC477.1 ssq-3; ZC477.1; 4H875; CE28161; NM_068712; WBGene00006052; WP:CE28161 ZC477.7 ZC477.7 ZC477.7; 4H874; CE05063; WBGene00022621; WP:CE05063 ZK1010.7 ZK1010.7 col-97; ZK1010.7; 3O82; CE15507; NM_067299; WBGene00000672; WP:CE15507 collagen ZK1128.3 ZK1128.3 ZK1128.3; 3L206; CE01685; WBGene00014229; WP:CE01685; YS03_CAEEL ZK1193.1 ZK1193.1 col-19; ZK1193.1; CE05126; COL19_CAEEL; NM_075699; WBGene00000608; WP:CE05126; XB41; col19 col-19 encodes a member of the collagen superfamily containing collagen triple helix repeats (20 copies) that is required for normal structure of the alae; expressed during the L2-to-dauer and L4-to-adult molts with strongest expression in adult animals. cuticular collagen ZK1225.4 ZK1225.4 ZK1225.4; 1N806; CE19343; WBGene00014238; WP:CE19343 ZK1225.6 ZK1225.6 ssp-31; ZK1225.6; 1N811; CE19345; NM_060917; SSP31_CAEEL; WBGene00006048; WP:CE19345 ZK1236.7 ZK1236.7 ZK1236.7; ZK1236.7.1; ZK1236.7.2; ZK1236.7.3; 3J530; CE29628; WBGene00022865; WP:CE29628; YO87_CAEEL ZK1248.17 ZK1248.17 ZK1248.17; 2G134; CE02901; WBGene00022884; WP:CE02901 major sperm protein ZK1248.6 ZK1248.6 msp-64; ZK1248.6; 2G100; NM_062748; WBGene00003457 msp-64 encodes a protein that belongs to a family of proteins called the Major Sperm Proteins (MSPs) that is conserved in nematodes; this family consists of closely related, small, basic proteins that make up 15% of sperm protein; this multigene family consists of over fifty genes, including many pseudogenes; MSPs are involved in both extracellular signaling and cytoskeletal functions during reproduction-MSP antagonizes Eph/ephrin signaling, in part, by binding VAB-1 Eph receptor tyrosine kinase on oocytes and sheath cells to promote oocyte maturation and MAPK activation; MSPs assemble into fibrous networks that drive movement of the C. elegans sperm; msp genes are expressed only in late primary spermatocytes. Major sperm protein ZK1251.6 ZK1251.6 msp-76; ZK1251.6; 4K453; MSP10_CAEEL; NM_069321; WBGene00003463 msp-76 encodes a protein that belongs to a family of proteins called the Major Sperm Proteins (MSPs) that is conserved in nematodes; this family consists of closely related, small, basic proteins that make up 15% of sperm protein; this multigene family consists of over fifty genes, including many pseudogenes; MSPs are involved in both extracellular signaling and cytoskeletal functions during reproduction-MSP antagonizes Eph/ephrin signaling, in part, by binding VAB-1 Eph receptor tyrosine kinase on oocytes and sheath cells to promote oocyte maturation and MAPK activation; MSPs assemble into fibrous networks that drive movement of the C. elegans sperm; msp genes are expressed only in late primary spermatocytes. major sperm protein (MSP1) ZK1290.3 ZK1290.3 rol-8; ZK1290.3; 2H835; CE29156; CE32085; COL6_CAEEL; NM_063181; NM_182112; WBGene00004398; WP:CE29156; WP:CE32085; col6 rol-8 encodes a collagen that is enriched in dauer larvae; mutations cause adults to become left-handed rollers. ZK1290.8 ZK1290.8 wrt-10; ZK1290.8; 2H824; CE02087; NM_063179; WBGene00006956; WP:CE02087 wrt-10 encodes a hedgehog-like protein, with an N-terminal signal sequence, a Wart domain, and a C-terminal region of low-complexity sequence; WRT-10 is expressed in both male and hermaphrodite intestine; the Wart domain is predicted to form a cysteine-crosslinked protein involved in intercellular signalling, and it has subtle similarity to the N-terminal Hedge domain of HEDGEHOG proteins; WRT-10 is required for normal growth to full size and locomotion; both of these requirements may reflect common defects in cholesterol-dependent hedgehog-like signalling or in vesicle trafficking. ZK1307.1 ZK1307.1 ZK1307.1; ZK1307.1b.1; ZK1307.1b.2; 2J946; CE01690; CE35921; WBGene00014244; WP:CE01690; WP:CE35921; YS11_CAEEL ZK1307.3 ZK1307.3 ZK1307.3; 2J944b; CE01692; WBGene00014246; WP:CE01692; YS13_CAEEL ZK1320.2 ZK1320.2 ZK1320.2; ZK1320.2.1; ZK1320.2.2; 2J948; CE01700; WBGene00014252; WP:CE01700; YS22_CAEEL ZK1320.3 ZK1320.3 ZK1320.3; ZK1320.3.1; ZK1320.3.2; 2J950; CE01701; WBGene00014253; WP:CE01701; YS23_CAEEL ZK265.2 ZK265.2 col-63; ZK265.2; 1I820; CE15291; NM_059844; WBGene00000639; WP:CE15291 collagen ZK265.3 ZK265.3 ZK265.3; 1I819; CE15293; WBGene00013956; WP:CE15293 ZK354.11 ZK354.11 msp-59; ZK354.11; 4G76; NM_068377; WBGene00003452 msp-59 encodes a member of the major sperm protein family. major sperm protein (MSP-59) ZK354.2 ZK354.2 ZK354.2; 4G79; CE15314; CE31749; WBGene00022705; WP:CE15314; WP:CE31749 protein kinase ZK354.4 ZK354.4 msp-113; ZK354.4; 4G63; NM_068372; WBGene00003468 msp-113 encodes a protein that belongs to a family of proteins called the Major Sperm Proteins (MSPs) that is conserved in nematodes; msp-113 has a C. briggsae homolog as detected by the Wobble Aware Bulk Aligner (WABA); the MSP family consists of closely related, small, basic proteins that make up 15% of sperm protein; this multigene family consists of over fifty genes, including many pseudogenes; the msp-113 promoter region contains two conserved cis elements that are recognition sites for elt-1, a gene that encodes a homolog of the vertebrate GATA transcription factor family; this suggests that a MSP protein is a potential target for ELT-1 in the germ-line; MSPs are involved in both extracellular signaling and cytoskeletal functions during reproduction-MSP antagonizes Eph/ephrin signaling, in part, by binding VAB-1 Eph receptor tyrosine kinase on oocytes and sheath cells to promote oocyte maturation and MAPK activation; MSPs assemble into fibrous networks that drive movement of the C. elegans sperm; msp genes are expressed only in late primary spermatocytes. major sperm protein (MSP-113) ZK354.5 ZK354.5 msp-51; ZK354.5; 4G60; NM_068370; WBGene00003444 msp-51 encodes a protein that belongs to a family of proteins called the Major Sperm Proteins (MSPs) that is conserved in nematodes; msp-51 has a C. briggsae homolog as predicted by the Wobble Aware Bulk Aligner (WABA); the MSP family consists of closely related, small, basic proteins that make up 15% of sperm protein; this multigene family consists of over fifty genes, including many pseudogenes; MSPs are involved in both extracellular signaling and cytoskeletal functions during reproduction-MSP antagonizes Eph/ephrin signaling, in part, by binding VAB-1 Eph receptor tyrosine kinase on oocytes and sheath cells to promote oocyte maturation and MAPK activation; MSPs assemble into fibrous networks that drive movement of the C. elegans sperm; msp genes are expressed only in late primary spermatocytes. major sperm protein (MSP-51) ZK354.6 ZK354.6 ZK354.6; 4G62; CE15320; WBGene00022707; WP:CE15320 protein kinase ZK354.8 ZK354.8 ZK354.8; 4G70; CE15324; WBGene00022709; WP:CE15324 protein phosphatase ZK455.1 ZK455.1 aco-1; gei-22; ZK455.1; ZK455.1.1; ZK455.1.2; ACOC_CAEEL; CE03812; NM_077497; WBGene00000040; WP:CE03812; XL961 aco-1 encodes an aconitase that is homologous to mammalian iron regulatory protein-1 (IRP1); aco-1 activity is required for normal brood sizes and, under iron stress conditions, for normal lifespan and L4-to-adult growth rates; ACO-1 physically interacts with GEX-3; like IRP1, ACO-1 has aconitase activity and is post-translationally regulated by iron, but, unlike IRP1, it lacks RNA-binding activity; ACO-1 is predicted to be mitochondrial, and its mRNA levels appear to decrease in response to iron treatment. iron-responsive element-binding like protein ZK484.5 ZK484.5 ZK484.5; 1G664; CE15345; WBGene00022751; WP:CE15345 ZK484.8 ZK484.8 ZK484.8; ZK484.8.1; ZK484.8.2; 1G674; CE15351; WBGene00022754; WP:CE15351 ZK520.5 ZK520.5 cyn-2; cyp-2; ZK520.5; ZK520.5.1; ZK520.5.2; 3O783; CE16730; CYP2_CAEEL; NM_067427; WBGene00000878; WP:CE16730 cyp-2 is a predicted member of the cytosolic CyclosporinA- binding cyclophilin family that is functional when expressed in E. coli. Peptidyl-prolyl cis-trans isomerases ZK525.2 ZK525.2 aqp-11; ZK525.2; 3O765; CE33909; NM_067420; WBGene00000179; WP:CE33909 ZK546.3 ZK546.3 ZK546.3; 2F231; CE02917; WBGene00022760; WP:CE02917 Major sperm protein ZK546.6 ZK546.6 msp-152; ZK546.6; 2F225; CE02920; MS152_CAEEL; NM_062500; WBGene00003470; WP:CE02920 msp-152 encodes a protein that belongs to a family of proteins called the Major Sperm Proteins (MSPs) that is conserved in nematodes; this family consists of closely related, small, basic proteins that make up 15% of sperm protein; this multigene family consists of over fifty genes, including many pseudogenes; MSPs are involved in both extracellular signaling and cytoskeletal functions during reproduction-MSP antagonizes Eph/ephrin signaling, in part, by binding VAB-1 Eph receptor tyrosine kinase on oocytes and sheath cells to promote oocyte maturation and MAPK activation; MSPs assemble into fibrous networks that drive movement of the C. elegans sperm; msp genes are expressed only in late primary spermatocytes. Major sperm protein ZK546.7 ZK546.7 ZK546.7; 2F223; CE02921; WBGene00022763; WP:CE02921 ZK550.5 ZK550.5 ZK550.5; 4S202; CE16736; WBGene00013999; WP:CE16736 ZK622.3 ZK622.3 phi-40; ZK622.3; ZK622.3a.1; ZK622.3a.2; ZK622.3a.3; ZK622.3c.1; ZK622.3c.10; ZK622.3c.11; ZK622.3c.2; ZK622.3c.3; ZK622.3c.4; ZK622.3c.5; ZK622.3c.6; ZK622.3c.7; ZK622.3c.8; ZK622.3c.9; ZK622.3d.1; ZK622.3d.2; ZK622.3d.3; ZK622.3d.4; ZK622.3d.5; ZK622.3d.6; ZK622.3d.7; ZK622.3d.8; 2F570; CE29162; CE32290; CE33504; CE33505; WBGene00022781; WP:CE29162; WP:CE32290; WP:CE33504; WP:CE33505 ZK637.12 ZK637.12 ZK637.12; 3K15; CE39882; WBGene00014029; WP:CE39882; YOUB_CAEEL ZK669.3 ZK669.3 ZK669.3; 2I235; CE01114; WBGene00014053; WP:CE01114; YO30_CAEEL ZK686.4 ZK686.4 ZK686.4; 3I860; CE00458; WBGene00022794; WP:CE00458; YO14_CAEEL ZK742.3 ZK742.3 ZK742.3; 5I288; CE07639; WBGene00022813; WP:CE07639 ZK792.2 ZK792.2 inx-8; opu-8; ZK792.2; ZK792.2.1; ZK792.2.2; 4M439; CE27419; INX8_CAEEL; NM_069808; WBGene00002130; WP:CE27419 inx-8 encodes a predicted member of the innexin family that affects fertility; expressed in sheath cells. Ogre family ZK809.1 ZK809.1 ZK809.1; 4M405; CE24741; WBGene00014085; WP:CE24741 protein-tyrosine phosphatase ZK813.1 ZK813.1 ZK813.1; ZK813.1.1; ZK813.1.2; CE33752; WBGene00022820; WP:CE33752; XE65 ZK813.2 ZK813.2 ZK813.2; CE05111; WBGene00022821; WP:CE05111; XE61 ZK813.3 ZK813.3 ZK813.3; CE29944; WBGene00022822; WP:CE29944; XE59 ZK896.5 ZK896.5 ZK896.5; ZK896.5.1; ZK896.5.2; 4N642; CE28276; WBGene00014136; WP:CE28276 ZK930.4 ZK930.4 ZK930.4; 2M199; CE06674; WBGene00014154; WP:CE06674 ZK945.1 ZK945.1 ZK945.1; 2K387; CE01731; WBGene00014164; WP:CE01731; YS81_CAEEL esterase ZK945.2 ZK945.2 pas-7; ZK945.2; ZK945.2.1; ZK945.2.2; 2K388; CE36420; NM_063776; PSA3_CAEEL; WBGene00003928; WP:CE36420 proteasome component (A-type) ZK945.7 ZK945.7 ZK945.7; 2K398; CE01738; WBGene00014169; WP:CE01738; YS87_CAEEL