|Gene list file name:||Fox2005_S14-T2_unc-4_neuron-transcript_TGF-beta-li|
|Type of gene identifier:||MA primer pair (sjj)|
|Description:||Fox et al 2005 Additional File 14/Table2: Summary of unc-4::GFP enriched and expressed (EGs) transcripts in selected categories. This file is an expanded version of Table 2 (see text) in which EGs are added to the list of enriched genes. Genes are organized as in Table 2 according to molecular function (KOG description, other description http://www.wormbase.org). Statistical rank is indicated for each enriched transcript and "EG" designates transcripts that are EGs.|
|Organism:||Caenorhabditis elegans (nematode)|
|Gene list type:||Experimental|
Gene name Source Gene ID Annotation Date Added by
C05D2.1 C05D2.1 P W All gene names: daf-4; C05D2.1; 3G721; CE16827; CE32114; CE33555; DAF4_CAEEL; NM_065810; WBGene00000900; WP:CE16827; WP:CE32114; WP:CE33555 WormBase description: daf-4 encodes a transmembrane serine/threonine kinase that is the sole C. elegans ortholog of the type II transforming growth factor-beta (TGF-b) receptors; DAF-4 activity is required for several biological processes, including entry into and exit from the dauer larval stage, body size determination, male tail patterning, egg laying, chemosensory neuron specification, and increased thermotolerance; in regulating dauer larval development, DAF-4 acts in parallel with the insulin signaling pathway and likely partners with the DAF-1 type I TGF-b receptor to receive a signal from the DAF-7 TGF-b ligand; in body size determination and male tail patterning, DAF-4 likely partners with the SMA-6 type I receptor and responds to signals from the DBL-1 ligand; DAF-4 expression begins in late embryogenesis and continues through larval and adult stages; consistent with its role in many developmental processes, DAF-4 localizes to the plasma membrane of several tissues including head and tail neurons, the pharynx, intestine, ventral nerve cord, tail hypodermis, and body wall muscle.
C53D6.2 C53D6.2 P W All gene names: unc-129; C53D6.2; 4J768; CE24863; NM_069165; O44371_CAEEL; WBGene00006852; WP:CE24863 WormBase description: The unc-129 gene encodes a member of the TGF-beta family of secreted growth factor signaling molecules; UNC-129 is required for proper axonal guidance of commissural motorneurons and for proper migration of the distal tip cells of the somatic gonad; UNC-129 is expressed in dorsal body wall muscle and at present does not appear to act through the known TGF-beta type I and II receptors. WormBase CDS description: bone morphogenetic protein like
F01G10.8 F01G10.8 P W All gene names: daf-14; F01G10.8; 4L19; CE29090; NM_069479; WBGene00000910; WP:CE29090 WormBase description: daf-14 encodes a Smad-related protein that is unusual in that while its C-terminus is well-conserved with Smad proteins, it lacks the N-terminal DNA binding domain found in all other known Smads; DAF-14 is predicted to function as a transducer of the DAF-7/TGF-beta-mediated signal that promotes reproductive growth and negatively regulates dauer formation; as reduction of daf-14 function enhances the dauer constitutive phenotype of daf-8 mutants, and overexpression of daf-14 can rescue daf-8 mutant animals, it is likely that the DAF-14 and DAF-8 Smad proteins function in parallel to control dauer formation; further genetic analyses suggest that DAF-14 and DAF-8 function to antagonize the activities of the DAF-3 Smad and DAF-5 Sno/Ski oncoprotein, which are required for dauer formation; a DAF-14::GFP reporter is expressed in a dynamic pattern in tissues, such as the hypodermis, intestine, and pharynx, that are remodeled during dauer development. WormBase CDS description: Mouse MSMAD protein like
F37D6.6 F37D6.6 P W All gene names: tag-68; F37D6.6; 1L81; CE36156; WBGene00006445; WP:CE36156
F39G3.8 F39G3.8 P W All gene names: tig-2; F39G3.8; 5F206; CE10126; NM_071870; WBGene00006570; WP:CE10126 WormBase description: The tig-2 gene, like dbl-1, daf-7, and unc-129, encodes a TGF-beta-like protein.
R12B2.1 R12B2.1 P W All gene names: sma-4; R12B2.1; R12B2.1a.1; R12B2.1a.2; R12B2.1a.3; 3G909; CE25077; CE39618; NM_065855; SMA4_CAEEL; WBGene00004858; WP:CE25077; WP:CE39618 WormBase description: The sma-4 gene encodes a homolog of human DPC4, which when mutated leads to pancreatic carcinoma (OMIM:260350).
T25F10.2 T25F10.2 P W All gene names: cet-1; dbl-1; T25F10.2; T25F10.2.1; T25F10.2.2; 5H239; CE26386; NM_072308; WBGene00000936; WP:CE26386 WormBase description: dbl-1 encodes a member of the transforming growth factor beta (TGFbeta) superfamily that includes Drosophila decapentaplegic (Dpp) and the vertebrate bone morphogenetic proteins (BMPs); DBL-1 functions as a dose-dependent ligand for the SMA-6 and DAF-4 TGFbeta receptors that ultimately activate the SMA-2, -3, and -4 complex of transcription factors to regulate body length and size, as well as the patterning of male sensory rays and copulatory spicules; DBL-1 signaling upregulates sma-6 expression, suggesting that there is positive autoregulation in the DBL-1 signaling pathway; in contrast, DBL-1 negatively regulates expression of LON-1, a predicted secreted protein that is a downstream component of the body size pathway; DBL-1 is expressed primarily in neurons. WormBase CDS description: TGF-beta-like growth factor