Blacque et al 2005, ST2 ciliated genes, 41 genes

Gene list file name:Blacque2005_ST2_42-ciliated-genes
Type of gene identifier:Cosmid name
Description:Blacque et al 2005 ST2 SAGE tag data for 42 genes known to be expressed in most ciliated cells (e.g., IFT-related genes) or in a subset of ciliated cells (e.g., tax-1, guanylate cyclases, receptors, and channels).  
Organism:Caenorhabditis elegans (nematode)
Gene list type:Experimental

Gene name             Source Gene ID          Annotation                                                  Date       Added by    

B0024.6 B0024.6 P W All gene names: gcy-6; B0024.6; 5K788; CE05151; NM_073249; WBGene00001533; WP:CE05151 WormBase description: gcy-6 encodes a predicted guanylate cyclase; expressed in the ASEL neurons. WormBase CDS description: guanylate cyclase (2 domains)
B0212.5 B0212.5 P W All gene names: nss-2; osm-9; B0212.5; 4E316; CE20445; NM_067971; WBGene00003889; WP:CE20445 WormBase description: The osm-9 gene encodes a capsaicin receptor homolog involved in sensory responses to a subset of chemical stimuli and to ASH neuron-mediated osmotic and mechanical stimuli; OSM-9 is also involved in adaptation to volatile odorants and salts. WormBase CDS description: olfacory channel
B0240.3 B0240.3 P W All gene names: daf-11; B0240.3; 5M200; CE05174; NM_073559; WBGene00000907; WP:CE05174 WormBase description: The daf-11 gene encodes a guanylate cyclase that affects dauer formation, chemotaxis, and axon formation; it is genetically upstream of daf-12 with respect to dauer larvae formation and is expressed in a subset of amphid neurons. WormBase CDS description: guanylate cyclase
B0412.2 B0412.2 P W All gene names: daf-7; B0412.2; 3B431; CE01758; DAF7_CAEEL; NM_064864; WBGene00000903; WP:CE01758 WormBase description: daf-7 encodes a member of the transforming growth factor beta superfamily that affects dauer larvae formation in a TGF-beta-mediated pathway and also affects egg laying; expressed in the ASI neurons. WormBase CDS description: transforming growth factor beta proteins
C06B3.8 C06B3.8 P W All gene names: gcy-32; C06B3.8; C06B3.8.1; C06B3.8.2; 5O392; CE30594; GCY32_CAEEL; NM_074051; WBGene00001552; WP:CE30594 WormBase description: gcy-32 encodes a predicted guanylate cyclase; expressed in URX, AQR, and PQR neurons. WormBase CDS description: guanylate cyclase
C27A7.4 C27A7.4 P W All gene names: che-11; mev-4; C27A7.4; 5M626; CE39480; NM_073646; WBGene00000490; WP:CE39480 WormBase description: che-11 encodes a large, unfamiliar protein with orthologs in vertebrates and arthropods (e.g., KIAA0590 and CG11838-PA) and in Chlamydomonas (IFT140), as well as distant similarity to OSM-1 and ZK520.1; che-11 is required for normal synthesis of sensory cilia (via intraflagellar transport) in sensory neurons, osmotic avoidance, and dauer formation.
C34D1.3 C34D1.3 P W All gene names: odr-3; C34D1.3; 5N728; CE08571; GPA17_CAEEL; NM_073889; WBGene00003850; WP:CE08571 WormBase description: guanine nucleotide-binding protein
C38D4.8 C38D4.8 P W All gene names: arl-query; bbs-3; C38D4.8; 3F900; ARL6_CAEEL; CE00921; NM_065592; WBGene00000193; WP:CE00921 WormBase description: arl-6 encodes an ADP-Ribosylation factor-Like member of the Ras superfamily of small GTP-binding proteins and is a predicted homolog of the human ARL6 gene, identified as the gene that underlies Bardet-Biedl syndrome type 3; GFP-tagged ARL-6 undergoes intraflagellar transport (IFT) in the ciliary axoneme, implicating ARL-6 in ciliary transport; arl-6 is expressed in amphid and phasmid ciliated sensory neurons. WormBase CDS description: ADP-ribosylation factor
C46E1.2 C46E1.2 P W All gene names: gcy-36; C46E1.2; CE39007; GCY36_CAEEL; NM_078156; WBGene00001556; WP:CE39007; XQ103 WormBase description: gcy-36 encodes a predicted soluble guanylate cyclase that genetically interacts with npr-1 with respect to feeding behavior; expressed in AQR, PQR, and URX3. WormBase CDS description: GUANYLATE CYCLASE SOLUBLE, BETA-2 CHAIN (EC 4.6.1.2) (76 KD CHAIN)
C49H3.1 C49H3.1 P W All gene names: gcy-8; C49H3.1; 4I697; CE20579; NM_068923; WBGene00001535; WP:CE20579 WormBase description: gcy-8 encodes a receptor-type guanylyl cyclase that, along with gcy-18 and gcy-23, constitutes a subfamily of guanylyl cyclase genes in C. elegans; gcy-8 functions redundantly with gcy-18 and gcy-23, and upstream of tax-4, to regulate thermotaxis via the AFD thermosensory neurons, although of the three guanylyl cyclases required, genetic analyses suggest that GCY-18 is the primary guanylyl cyclase required; GCY-8 is expressed exclusively in the AFD thermosensory neurons where it localizes to sensory endings; GCY-8 expression in the AFD neurons requires activity of the TAX-2/4 cyclic nucleotide gated channel and the CMK-1 Ca2+/calmodulin-dependent protein kinase I, while maintenance of GCY-8 expression requires the OTD/OTX homeodomain protein TTX-1. WormBase CDS description: receptor-type guanylyl cyclase
C53B7.5 C53B7.5 P W All gene names: odr-10; C53B7.5; CE26361; NM_076756; WBGene00003856; WP:CE26361; XH484 WormBase description: odr-10 encodes a member of the 7-transmembrane family of odorant receptors which affects chemotaxis to the volatile odorant diacetyl; ODR-10 is strongly expressed in the cilia of the AWA olfactory neurons and, at low levels, in the CEP neurons; expression of odr-10 mRNA and of an odr-10::GFP fusion gene is greatly reduced in odr-7 mutant animals, suggesting that odr-7, which encodes a predicted transcription factor, functions upstream of odr-10 in specifying AWA neuronal cell fate. WormBase CDS description: chemoreceptor
C55B7.12 C55B7.12 P W All gene names: che-1; tax-1; tax-5; C55B7.12; 1H94; CE34280; CHE1_CAEEL; NM_059476; WBGene00000483; WP:CE34280 WormBase description: che-1 encodes a C2H2-type zinc finger-containing transcription factor orthologous to Drosophila GLASS, which is required for photoreceptor cell differentiation; CHE-1 is required for determining the identity and function of the amphid ASE neurons, the major neurons that mediate chemotaxis to water-soluble attractants; CHE-1 is expressed predominantly in the ASE neurons and regulates, either directly or indirectly, the expression of a number of ASE-specific genes.
F02D8.3 F02D8.3 P W All gene names: xbx-1; F02D8.3; 5P459; CE39142; NM_074282; WBGene00006960; WP:CE39142
F08B1.2 F08B1.2 P W All gene names: gcy-12; F08B1.2; 2F607; CE27920; NM_062594; WBGene00001538; WP:CE27920 WormBase description: gcy-12 encodes a predicted guanylate cyclase that affects chemotaxis to isoamyl alcohol; expressed in PHA neurons and in AFD neurons. WormBase CDS description: guanylate cyclase
F08F8.3 F08F8.3 P W All gene names: F08F8.3; CE27931; CE30650; WBGene00002182; WP:CE27931; WP:CE30650
F18C12.1 F18C12.1 P W All gene names: avr-1; caf-2; che-3; che-8; osm-2; F18C12.1; 1I638; CE32386; NM_059820; WBGene00000485; WP:CE32386 WormBase description: The dynein heavy chain (DHC) 1b isoform that affects the establishment and maintainance of the structural integrity of sensory cilia and also has a role in intraflagellar transport; it is expressed in ciliated sensory neurons. WormBase CDS description: dynein heavy chain
F20D12.3 F20D12.3 P W All gene names: bbs-2; F20D12.3; 4I701; CE04433; NM_068924; WBGene00000242; WP:CE04433 WormBase description: bbs-2 is orthologous to human BBS2 (OMIM:606151, mutated in Bardet-Biedl syndrome 2); while the function of BBS-2 is unknown, it shares conserved domains with its human paralogs BBS1 and BBS7, which also are mutated in other Bardet-Biedl syndromes.
F32A6.2 F32A6.2 P W All gene names: F32A6.2; CE34008; WBGene00017973; WP:CE34008; XF921
F33H1.1 F33H1.1 P W All gene names: daf-19; daf-24; F33H1.1; 2K448; CE17763; CE28019; DAF19_CAEEL; WBGene00000914; WP:CE17763; WP:CE28019 WormBase description: daf-19 is the sole C. elegans member of the RFX family of transcription factors, and is required for sensory neuron cilium formation; DAF-19 is expressed in ciliated sensory neurons during the period that their cilia are generated, and probably functions as an common transcriptional activator of many genes that specifically encode cilial structures in sensory neurons; daf-19 mutants lack sensory cilia, have abnormal amphids, are strongly dauer-constutive, lack normal openings of the amphids to the external environment (i.e., fail to show dye-filling), and are highly defective in their ability to taste or smell; DAF-19 regulates bbs-5, che-2, che-13, dyf-3, osm-1, osm-6, and xbx-1 expression, and probably regulates ~200 other genes (e.g., bbs-2, bbs-7 and bbs-8); the localization of DAF-6 is aberrant in daf-19 mutants. WormBase CDS description: DNA binding transcription factor
F36F2.5 F36F2.5 P W All gene names: nrf-7; tax-2; F36F2.5; 1J601; CE17780; NM_060026; WBGene00006525; WP:CE17780 WormBase description: tax-2 is orthologous to the human gene ROD PHOTORECEPTOR CNG-CHANNEL BETA SUBUNIT (CNGB1; OMIM:600724), which when mutated leads to disease. WormBase CDS description: cyclic nucleotide-gated channel
F38G1.1 F38G1.1 P W All gene names: che-2; F38G1.1; F38G1.1.1; F38G1.1.2; CE25876; NM_075705; WBGene00000484; WP:CE25876; XB103 WormBase description: che-2 encodes a protein that contains G-protein beta-like WD-40 repeats that affects chemotaxis, dauer formation, and longevity; expressed in the cilia of most ciliated sensory neurons, some head neurons, and male tail rays. WormBase CDS description: G-beta-repeats
F59C6.7 F59C6.7 P W All gene names: che-13; che-9; F59C6.7; 1L82; CE31704; NM_060348; WBGene00000492; WP:CE31704 WormBase description: che-13 encodes a novel protein homologous to mammalian IFT57/Hippi (OMIM:606621, protein interactor of Huntingtin-interacting protein 1 that is implicated in neuronal apoptosis in the Huntington disease state); CHE-13 is a proposed component of the intraflagellar transport (IFT) complex B, and is required for the construction and maintenance of cilia on a subset of sensory neurons; in addition, CHE-13 is required for proper localization of OSM-5, a murine polaris homolog, to IFT complex B; CHE-13 is expressed in ciliated sensory neurons including the amphids, phasmids, inner and outer labial neurons, and sensory rays of the male tail, localizing to the cilia base (transition zone) as well as to the axoneme; che-13 expression, like that of ciliogenic genes osm-1, osm-5, osm-6, and che-2, is positively regulated by the DAF-19 RFX-type transcription factor.
M02B7.3 M02B7.3 P W All gene names: caf-1; klp-2; osm-3; M02B7.3; M02B7.3a.1; M02B7.3a.2; 4E562; CE31567; CE31568; NM_171308; OSM3_CAEEL; WBGene00003884; WP:CE31567; WP:CE31568 WormBase description: osm-3 encodes a homolog of the heavy chain subunit of heteromeric anterograde motor kinesins; OSM-3 is required for formation of the distal segment of amphid channel cilia, for responses to osmotic stimuli, for normal dauer formation, and for sensitivity to caffeine.
M04G12.3 M04G12.3 P W All gene names: gcy-34; M04G12.3; 5N864; CE12426; GCY34_CAEEL; NM_073918; WBGene00001554; WP:CE12426 WormBase description: gcy-34 encodes a predicted soluble guanylyl cyclase that is expressed in four candidate sensory neurons connected to the pseudocoelom, URXL, URXR, AQR, and PQR; as loss of gcy-34 activity via RNA-mediated interference does not result in any abnormalities, the precise role of GCY-34 in C. elegans development and/or behavior is not yet known; GCY-34 expression in neurons connected to the pseudocoelom suggests, however, that GCY-34 may play a role in fluid homeostasis. WormBase CDS description: guanylate cyclase beta chain like
M28.7 M28.7 P W All gene names: nph-1; nphp-1; M28.7; 2K940; CE16278; NM_063897; NPHP1_CAEEL; WBGene00010898; WP:CE16278 WormBase description: nph-1 encodes a novel, SH3 domain-containing protein that is orthologous to mammalian nephrocystin-1. WormBase CDS description: SH3 domain
R01E6.1 R01E6.1 P W All gene names: gcy-10; odr-1; R01E6.1; CE27430; NM_077865; WBGene00003848; WP:CE27430; XO162 WormBase description: odr-1 encodes a putative guanylyl cyclase; odr-1 activity is required for normal responses to all AWC-sensed odorants; ODR-1 is expressed in chemosensory neurons including AWC, where it localizes to the flattened ciliated endings. WormBase CDS description: guanylate cyclase
R01H10.6 R01H10.6 P W All gene names: bbs-5; R01H10.6; 3L348; CE01042; NM_066871; Q21626_CAEEL; WBGene00010974; WP:CE01042
R13H4.1 R13H4.1 P W All gene names: nph-4; nphp-4; R13H4.1; 5M312; CE38409; NM_073581; WBGene00011261; WP:CE38409
R31.3 R31.3 P W All gene names: osm-6; R31.3; 5M406; CE27774; NM_171545; WBGene00003886; WP:CE27774 WormBase description: osm-6 males are defective in their response to hermaphrodite-derived diffusible cues. WormBase CDS description: N-acetyllactosamine synthase
T18D3.2 T18D3.2 P W All gene names: odr-7; T18D3.2; CE03663; NM_077688; ODR7_CAEEL; WBGene00003854; WP:CE03663; XN78 WormBase description: odr-7 encodes an olfactory-specific member of the nuclear receptor superfamily that affects chemotaxis to some volatile odorants and the cell fate of the AWA olfactory neurons; ODR-7 is expressed in the AWA neurons; in specifying the identity of the AWA neurons, ODR-7 appears to lie upstream of odr-10, which encodes a seven transmembrane domain olfactory receptor that is required for the response to diacetyl, an odorant detected by the AWA neurons. WormBase CDS description: Zinc finger, C4 type (two domains)
T25F10.5 T25F10.5 P W All gene names: bbs-8; T25F10.5; 5H242; CE31071; NM_072310; WBGene00000244; WP:CE31071 WormBase description: bbs-8 encodes a tetratricopeptide repeat (TPR)-containing protein that is orthologous to the human Bardet-Biedl syndrome protein, BBS8; in C. elegans, bbs-8 activity is required for cilia biogenesis and function; accordingly, bbs-8 mutant animals display odorant chemotaxis defects and exhibit both aberrant motility and abnormal localization of at least two intraflagellar transport (IFT) protein markers; a BBS-8::GFP translational fusion is expressed exclusively in ciliated head and tail neurons, where it localizes predominantly to the base of cilia, known as the ciliary transition zone; BBS-8::GFP is also observed moving bidirectionally (anterograde and retrograde) along the ciliary axoneme; DNA sequences upstream of bbs-8 contain X box DNA binding sites, suggesting that bbs-8 expression may be regulated by the DAF-19 RFX-type transcription factor.
T26C12.4 T26C12.4 P W All gene names: gcy-23; T26C12.4; 4E46; CE36614; NM_067908; WBGene00001548; WP:CE36614 WormBase description: gcy-23 encodes a receptor-type guanylyl cyclase that, along with gcy-8 and gcy-18, constitutes a subfamily of guanylyl cyclase genes in C. elegans; gcy-23 functions redundantly with gcy-8 and gcy-18, and upstream of tax-4, to regulate thermotaxis via the AFD thermosensory neurons, although of the three guanylyl cyclases required, genetic analyses suggest that GCY-18 is the primary guanylyl cyclase required; in addition, loss of gcy-23 activity via RNAi results in lifespan extension; GCY-23 is expressed exclusively in the AFD thermosensory neurons, where it localizes to sensory endings.
T27B1.1 T27B1.1 P W All gene names: osm-1; T27B1.1; CE39420; NM_078280; WBGene00003883; WP:CE39420; XR165 WormBase description: osm-1 encodes a predicted intraflagellar transport (IFT) raft protein and is a presumptive cargo molecule for kinesin-II, and OSM-1 is required along with OSM-6 for the proper assembly of the middle segments of sensory cilia; osm-1 may act in a pathway with avr-14 to affect resistance to ivermectin-induced cessation of pumping, and mutants are defective in avoidance of solutions of high osmotic strength. WormBase CDS description: leucine zipper transcription factor(weak)
Y102E9.1 Y102E9.1 P W All gene names: odr-4; Y102E9.1; Y102E9.1a.1; Y102E9.1a.2; Y102E9.1a.3; Y102E9.1a.4; 3H823; CE28101; CE32953; CE32954; NM_066076; WBGene00003851; WP:CE28101; WP:CE32953; WP:CE32954 WormBase description: odr-4 encodes a novel type II membrane protein required for the localization of a subset of seven transmembrane domain odorant receptors, including ODR-10, to the cilia of olfactory neurons, it affects response to a subset of AWA- and AWC- mediated olfactory responses, and is required for social feeding of npr-1 mutant animals; expressed in 12 pairs of chemosensory neurons.
Y105E8A.5 Y105E8A.5 P W All gene names: bbs-1; Y105E8A.5; 1O962; CE25181; NM_170937; WBGene00000241; WP:CE25181
Y41G9A.1 Y41G9A.1 P W All gene names: osm-5; Y41G9A.1; CE28361; NM_076110; WBGene00003885; WP:CE28361; XD609 WormBase description: The osm-5 gene encodes a homolog of the murine cystic kidney disease gene Tg737 that is required for the production of cilia in sensory neurons.
Y50D7A.6 Y50D7A.6 P W All gene names: klp-20; Y50D7A.6; 3A851; CE26143; NM_064777; WBGene00002230; WP:CE26143; krp85
Y75B8A.12 Y75B8A.12 P W All gene names: osm-12; Y75B8A.12; Y75B8A.P; 3N280; CE23024; NM_067184; Q9XW70_CAEEL; WBGene00003892; WP:CE23024
ZC84.2 ZC84.2 P W All gene names: tax-4; ZC84.2; 3K275; CE27352; CNG_CAEEL; NM_066632; WBGene00006526; WP:CE27352 WormBase description: tax-4 is orthologous to the human gene ROD PHOTORECEPTOR CGMP-GATED CHANNEL (CNGA1; OMIM:123825), which when mutated leads to disease. WormBase CDS description: Cyclic-nucleotide-gated olfactory channel
ZK970.6 ZK970.6 P W All gene names: gcy-5; ZK970.6; 2K602; CE02406; NM_063818; WBGene00001532; WP:CE02406 WormBase description: gcy-5 encodes a predicted guanylate cyclase with strong similarity to rat atrial natriuretic peptide receptor A; expressed in ASER. WormBase CDS description: guanylate cyclase