Gene_cosmid_name All names Proteome description WormBase description ------------------------------------------------------------------------------ 116A8A.E Y116A8C.21;116A8A.E Protein of unknown function, has low similarity to uncharacterized C. elegans Y116F11A.4 1G758 1G758 Protein that interacts with the Hsp70 chaperone 2L52.A 2L52.1;2L52.A Protein containing two C2H2 type zinc finger domains, which bind nucleic acids 2L737 2L737 Putative ortholog of C. elegans VW02B12L.4 gene product 2O676 2O676 Protein with moderate similarity to C. elegans F26H11.1 gene product 3I332 3I332 Proteasome component C5 3I940 3I940 Putative ortholog of C. elegans F44E2.9 gene product 3R5.1 3R5.1 Protein of unknown function, has high similarity to uncharacterized C. elegans F57C2.3 3R5.2 3R5.2 Putative ortholog of C. elegans K08E3.8 gene product 4D561 4D561 Putative ortholog of C. elegans Y94H6A_1.A gene product 4F223 4F223 Putative ortholog of C. elegans R08C7.12 gene product 4R79.1 4R79.1 Member of the astacin (M12A) family of metalloproteases, has a region of moderate similarity to a region of the beta subunit of meprin A (rat Mep1b), which is an integral membrane protein that may play a role in embryogenesis Zinc-binding metalloprotease domain 4R79.2 4R79.2 Member of the Ras superfamily of GTP-binding proteins, has a region of moderate similarity to S. cerevisiae Sec4p, which is a GTP-binding protein involved in vesicular transport between the Golgi and plasma membrane Ras family 4R79.3 F11E6.1;4R79.3 Member of the glycosyl hydrolase family 30, which are glucosyl-ceramidases, has moderate similarity to acid beta glucosidase (beta-glucocerebrosidase, mouse Gba), which is a lysosomal membrane protein that hydrolyzes glucosylceramide 5C820 5C820 Putative ortholog of C. elegans F15E11.12 gene product 5HT3-CE 5HT3-Ce Member of the rhodopsin family of G protein-coupled receptors (GPCR), has moderate similarity to 5-hydroxytryptamine (serotonin) 1A receptor (mouse Htr1a), which is a G protein-coupled receptor that acts via Gi-Go to inhibit adenylyl cyclase 5N224 5N224 Protein with strong similarity to C. elegans C15C8.7 gene product 6R55.1 6R55.1 Putative ortholog of C. elegans 6R55.1 gene product 6R55.2 6R55.2 Protein of unknown function 9F54G8.5 ptr;9F54G8.5 Member of the patched family, which are transmembrane receptors, has weak similarity to a region of Niemann-Pick disease type C1 (human NPC1), which is a lysosomal protein that plays a role cholesterol transport AC3.1 AC3.1 Member of the 7-transmembrane chemoreceptor family of G protein-coupled receptors (GPCR), has low similarity to uncharacterized C. elegans F34D6.6 7TM chemoreceptor, sri family AC3.2 AC3.2 Protein containing four UDP-glucoronosyl and UDP-glucosyl transferase domains, which transfer glycosyl groups to small hydrophobic molecules, has a region of low similarity to UDP glycosyltransferase 1 A3 (human UGT1A3) UDP-glucuronosyltransferase AC3.3 AC3.3 Protein containing eleven uncharacterized cysteine repeat domains, has strong similarity to uncharacterized C. elegans Y73F8A.9 abu-1 encodes a transmembrane protein with a predicted signal sequence, a glutamine/asparagine-rich domain and multiple cysteine-rich repeats (DUF139); abu-1 expression is induced by blockage of the unfolded-protein response in the endoplasmic reticulum, and ABU-1 may help protect the organism from damage by improperly folded nascent protein. AC3.4 AC3.4 Protein containing a DHHC-type zinc finger NEW1 domain, has a region of low similarity to a region of Huntingtin interacting protein H (human HYPH), which interacts with huntingtin (human HD) and may play a role in Huntington disease The protein product of this gene is predicted to contain a glutamine/asparagine (Q/N)-rich ('prion') domain, by the algorithm of Michelitsch and Weissman (as of the WS77 release of WormBase, i.e., in wormpep77). AC3.5 AC3.5 Member of the M1 peptidase family of aminopeptidases, has weak similarity to leucine aminopeptidase (oxytocinase, human LNPEP), which is an insulin-regulated zinc aminopeptidase that degrades oxytocin and vasopressin glutamyl aminopeptidase AC3.6 AC3.6 Protein containing two collagen triple helix repeats, which are found in some extracellular proteins, and a nematode cuticle collagen N-terminal domain, has a region of moderate similarity to a region of C. elegans BLI-1 collagen AC3.7 AC3.7 Protein containing a UDP-glucoronosyl and UDP-glucosyl transferase domain, which transfer glycosyl groups to small hydrophobic molecules, has weak similarity to UDP-glycosyltransferase 1 A9 (human UGT1A9), which plays a role in drug metabolism UDP-glucuronosyltransferase AC3.8 AC3.8 Protein containing a UDP-glucoronosyl and UDP-glucosyl transferase domain, which transfer glycosyl groups to small hydrophobic molecules, has weak similarity to UDP glycosyltransferase 1 family polypeptide A6 (mouse Ugt1a6) UDP-glucuronosyltransferase AC7.1 AC7.1 Member of the rhodopsin family of G protein-coupled receptors (GPCR), has low similarity to tachykinin receptor 1 (substance P receptor, rat TACR1), is involved in pain transmission, inflammation, perception of noxious stimuli, and behavior G-protein coupled receptor AC7.2 soc-2;sur-8;AC7.2 Positive regulator of the let-60 ras pathway and vulval induction AC7.3 AC7.3 Protein of unknown function AC8.6 AC8.6 Protein of unknown function, has strong similarity to C. elegans AC8.J AC8.B AC8.2;AC8.B Putative ortholog of C. elegans Y71F9AL.2 gene product AC8.D AC8.1;AC8.A;AC8.D Protein containing a poly(ADP-ribose) polymerase regulatory domain, a Poly(ADP-ribose) polymerase zinc finger domain, and a Poly(ADP-ribose) polymerase catalytic domain, has low similarity to mouse Adprt1, which plays a role in DNA damage response AC8.E AC8.7;AC8.E Protein of unknown function, has weak similarity to C. elegans F25G6.1 AC8.F AC8.3;AC8.F Protein of unknown function, has low similarity to uncharacterized C. elegans F25G6.1 AC8.G AC8.4;AC8.G Protein of unknown function, has weak similarity to C. elegans H12D21.8 AC8.I AC8.5;AC8.I Protein of unknown function, has high similarity to uncharacterized C. elegans Y48E1B.7 ADS-1 ads-1 Alkyl-dihydroxyacetonephosphate synthase AH10.1 AH10.1 Member of the AMP-binding enzyme family, has low similarity to C. albicans Acs1p, which is an acetyl-coenzyme A synthetase (acetate-coA ligase) 4-coumarate:coenzyme A ligase AH10.2 AH10.2 Protein of unknown function, has high similarity to uncharacterized C. elegans Y75B12A.2 AH10.3 AH10.3 Protein of unknown function AH10.4 AH10.4 Protein of unknown function, has strong similarity to uncharacterized C. elegans ZK84.4 AH10.5 AH10.5 Small protein of unknown function, identical to a region in the N-terminus of C. elegans PAR-1 AH6.1 gcy-1;AH6.1 Putative guanylyl cyclase guanylate cyclase; gcy-1 is predicted to encode a guanylate cyclase; however, transcriptional fusions of the putative upstream regulatory region with a GFP reporter did not confirm its expression. AH6.10 sra-6;AH6.10 G protein-coupled receptor, expressed in chemosensory neurons, no homolog found in human or D. melanogaster 7TM chemoreceptor, sra family AH6.11 sra-7;AH6.11 G protein-coupled receptor, expressed in chemosensory neurons, no homolog found in human or D. melanogaster 7TM chemoreceptor, sra family AH6.12 sra-8;AH6.12 G protein-coupled receptor; member of a subfamily with SRA proteins, which are expressed in chemosensory neurons; no homolog found in human or D. melanogaster 7TM chemoreceptor, sra family AH6.13 AH6.13 Member of C. elegans Sra integral membrane protein family, which contain 6-7 hydrophobic, putative transmembrane, regions, has moderate similarity to uncharacterized C. elegans SRA-2 AH6.14 sra-9;AH6.14 G protein-coupled receptor, expressed in chemosensory neurons, no homolog found in human or D. melanogaster 7TM chemoreceptor, sra family AH6.2 AH6.2 Member of the mitochondrial tricarboxylate carrier (MTC) protein family AH6.3 AH6.3 Protein of unknown function, has weak similarity to the DNA-binding domain of the human nucleoplasmic protein NP220(Hs.169984) AH6.4 sra-1;AH6.4 G protein-coupled receptor, expressed in chemosensory neurons, no homolog found in human or D. melanogaster 7TM chemoreceptor, sra family; sra-1 encodes a predicted seven transmembrane receptor; expressed in the male SPD and SPV neurons. AH6.5 mex-6;AH6.5 Non-essential protein that appears to have partially overlapping function with MEX-5 in repression of germline-specific proteins in the anterior of embryos zinc finger protein; mex-6 encodes a CCCH zinc-finger protein highly similar to MEX-5 that functions with MEX-5 to affect embryonic viability, establish soma germline asymmetry in embryos and establish PIE-1, MEX-1, and POS-1 asymmetry in embryos, and also affects formation of intestinal cells; MEX-6 and MEX-5 may act downstream of the PAR proteins. AH6.6 sra-2;AH6.6 Member of the 7TM receptor protein family 7TM chemoreceptor, sra family AH6.7 sra-3;AH6.7 G protein-coupled receptor; member of a subfamily with SRA proteins, which are expressed in chemosensory neurons; no homolog found in human or D. melanogaster 7TM chemoreceptor, sra family AH6.8 sra-4;AH6.8 G protein-coupled receptor; member of a subfamily with SRA proteins, which are expressed in chemosensory neurons; no homolog found in human or D. melanogaster 7TM chemoreceptor, sra family AH6.9 sra-5;AH6.9 G protein-coupled receptor; member of a subfamily with SRA proteins, which are expressed in chemosensory neurons; no homolog found in human or D. melanogaster AH9.1 AH9.1 Member of the rhodopsin family of G protein-coupled receptors (GPCR), has low similarity to uncharacterized C. elegans B0563.6 transmembrane domain of family 1 of G-protein coupled receptors AH9.2 AH9.2 Member of the exonuclease family AH9.3 AH9.3 Protein of unknown function AH9.4 AH9.4 Protein of unknown function ASC-1 asc-1 Protein with similarity to human TRIP4, which interacts with the ligand binding domain of the thyroid hormone receptor to activate transcription ATPASE6 ATP6;ATPase6 Member of the ATP synthase A chain family B0001.1 B0001.1 Protein of unknown function, has low similarity to uncharacterized C. elegans C31H1.6 B0001.2 B0001.2 Protein with moderate similarity to C. elegans C49A9.1 gene product B0001.3 B0001.3 Protein with moderate similarity to C. elegans B0001.5 gene product B0001.4 B0001.4 Protein with high similarity to uridine monophosphate kinase (human UMPK), which phosphorylates uridine, cytidine, and their analogs and functions in pyrimidine nucleoside and drug metabolism, member of the phosphoribulokinase and uridine kinase family uridine kinase like B0001.5 B0001.5 Protein of unknown function, has low similarity to uncharacterized C. elegans B0001.8 B0001.6 B0001.6 Coiled-coil protein of unknown function, has similarity over coiled-coil regions to S. cerevisiae Mlp1p and Num1p B0001.7 B0001.7 Protein of unknown function B0001.8 B0001.8 Protein with strong similarity to C. elegans B0001.5 gene product B0019.1 B0019.1 Protein with similarity over N-terminal half to human monoamine oxidases MAOA and MAOB B0019.2 B0019.2 Protein with strong similarity to C. elegans F28H6.5 gene product B0019.3 B0019.3 Protein with strong similarity to the C. elegans Y18D10A.A gene product B0024.1 B0024.1 Protein containing two collagen triple helix repeats, which are found in some extracellular proteins, and a nematode cuticle collagen N-terminal domain, has moderate similarity to a region of C. elegans BLI-1 collagen B0024.10 B0024.10 Protein of unknown function, has weak similarity to human myosin MYH9 and laminin LAMB1 B0024.11 B0024.11 Member of the uncharacterized protein family UPF0024, has low similarity to uncharacterized S. pombe Spbc1a4.09p Uncharacterized protein family UPF0024 B0024.12 gna-1;CeGNA1;B0024.12 Protein containing an acetyltransferase (GNAT) domain, has moderate similarity to glucosamine-phosphate N-acetyltransferase 1 (mouse Gpnat1), which is an apoptosis regulator acting in O-glycosylation, N-acetylglucosamine synthesis and actin polymerization Acetyltransferase (GNAT) family; gna-1 encodes one of two C. elegans glucosamine 6-phosphate N-acetyltransferases (GNAs); by homology, GNA-1 is predicted to be required for the formation of UDP-N-acetylglucosamine, a substrate in chitin synthesis, Golgi and cytoplasmic glycosylation, and GPI anchoring; as loss of gna-1 activity via large-scale RNAi screens does not result in any obvious abnormalities, the precise role of GNA-1 in C. elegans development and/or behavior is not yet known. B0024.13 B0024.13 Member of the 3-oxo-5-alpha-steroid 4-dehydrogenase family, which are involved in dihydrotestosterone biosynthesis, has low similarity to S. cerevisiae Dfg10p, which is involved in filamentous growth, cell polarity, and cellular elongation B0024.14 B0024.14 Member of the antistasin family, which are inhibitors of trypsin family proteases, contains four von Willebrand factor (vWF) type C domains, has a region of weak similarity to a region of nel-related protein 2 (rat Nell2), which binds heparin pro-collagen domains B0024.2 B0024.2 Protein containing two collagen triple helix repeats, which are found in some extracellular proteins, and a nematode cuticle collagen N-terminal domain, has low similarity to C. elegans ROL-6 collagen B0024.3 B0024.3 Member of the galactosyltransferase family, which transfer galactose to GlcNAc termini of growing oligosaccharide chains, has a region of low similarity to UDP-galactose:beta-N-acetylglucosamine beta-1,3-galactosyltransferase (human B3GALT1) B0024.4 B0024.4 Protein of unknown function, has moderate similarity to uncharacterized C. elegans ZK6.10 B0024.6 gcy-6;B0024.6 Putative guanylyl cyclase expressed in the ASEL neuron guanylate cyclase (2 domains); gcy-6 encodes a predicted guanylate cyclase; expressed in the ASEL neurons. B0024.8 B0024.8 Putative ortholog of C. elegans B0024.5 gene product B0024.9 B0024.9 Member of the thioredoxin protein family, which are small enzymes involved in redox reactions, has low similarity to thioredoxin I (S. cerevisiae Trx1p) thioredoxin; This gene encodes a protein predicted by Eisenberg and coworkers, with 52% accuracy, to be mitochondrial. B0025.1 let-512;vps-34;B0025.1 Protein containing two PIK domains (phosphoinositide 3-kinase accessory domains), a phosphoinositide 3-kinase C2 domain, and two phosphatidylinositol 3- and 4-kinase domains, has moderate similarity to phosphatidylinositol 3-kinase class 3 (rat Pik3c3) phosphatidylinositol 3-kinase; The vps-34 gene encodes an ortholog of the phosphoinositide 3-kinase VPS34 in S. cerevisiae, a protein that regulates multiple steps in endocytosis, and that is required for growth at normal rates during development. B0025.2 B0025.2 Protein with high similarity to thyroid receptor interacting protein 15 (human TRIP15), which is a nuclear hormone transcription corepressor, contains a PCI (proteasome, COP9-complex and eIF3 ) or PINT (Proteasome, Int-6, Nip-1 and TRIP-15) domain csn-2 encodes a homolog of COP9 signalosome complex subunit 2 that affects embryonic viability and growth rate. B0025.4 B0025.4 Protein of unknown function B0034.1 B0034.1 Protein of unknown function B0034.2 B0034.2 Protein of unknown function B0034.3 cdh-11;B0034.3 Protein containing a cadherin domain, which are found in the extracellular domain of some receptors and cell adhesion proteins, has low similarity to uncharacterized human KIAA0911 A homolog of a member of the cadherin superfamily which is involved in cell-cell adhesion. B0034.4 B0034.4 Protein of unknown function B0034.5 B0034.5 Protein with strong similarity to C. elegans R11F4.2 gene product B0035.1 B0035.1 Protein of unknown function, has moderate similarity to uncharacterized zinc finger protein 207 (human ZNF207) Zinc finger, C2H2 type B0035.10 B0035.10 Member of the histone H3 protein family histone H3; his-45 encodes an H3 histone. B0035.11 B0035.11 Protein of unknown function, has low similarity to uncharacterized S. cerevisiae Leo1p Yeast LEO1 protein like B0035.12 B0035.12 Protein related to human nuclear RNA binding protein p110nrb polyadenylate-binding protein like B0035.13 B0035.13 Member of the lipase class 3 family, which are a subset of lipolytic enzymes that hydrolyze ester linkages of triglycerides, has high similarity to uncharacterized C. elegans F28H7.3 lipase B0035.14 B0035.14 Protein containing a DnaJ domain, which are part of chaperone system that mediates interaction with heat shock proteins, has a region of moderate similarity to a region of dnaJ homolog subfamily B member 4 (human DNAJB4), which is a heat shock protein DNAJ protein like; This gene encodes a protein containing a DnaJ ('J') domain. B0035.15 B0035.15 Protein of unknown function B0035.16 B0035.16 Member of the tRNA methyl transferase family, which are involved in nucleoside 5-methylaminomethyl-2-thiouridine biosynthesis, has low similarity to uncharacterized S. pombe SPAC23H4.04 Haemophilus hypothetical protein HI1074 like; This gene encodes a protein predicted by Eisenberg and coworkers, with 68% accuracy, to be mitochondrial. B0035.2 B0035.2 Protein containing a DnaJ domain, which are part of the chaperone (protein folding) system that mediates interaction with heat shock proteins DNAJ protein like; This gene encodes a protein containing a DnaJ ('J') domain. B0035.3 B0035.3 Member of the Appr-1 double prime-p processing enzyme family viral non-structural protein like B0035.4 B0035.4;4M79 Protein of unknown function; has moderate similarity to H. sapiens PFDN4 (prefoldin 4), which may have a role in cell cycle paramyosin like B0035.5 B0035.5 Protein with high similarity to glucose-6-phosphate dehydrogenase (human G6PD), which is involved in the pentose phosphate pathway and is associated with hemolytic anemia, contains glucose-6-phosphate dehydrogenase C-terminal and NAD binding domains glucose-6-phosphate-1-dehydrogenase; B0035.5 is orthologous to the human gene GLUCOSE-6-PHOSPHATE DEHYDROGENASE (G6PD; OMIM:305900), which when mutated leads to disease. B0035.6 B0035.6 Protein of unknown function, has high similarity to uncharacterized C. elegans Y111B2A.3 B0035.7 B0035.7 Protein with strong similarity to H2A histone family member X (mouse H2afx), which binds DNA during nucleosome formation and is phosphorylated following DNA double-strand breaks in recombination, member of the histone family of nucleosomal core proteins histone H2A; his-47 encodes an H2A histone; by homology, HIS-47 is predicted to function as a nucleosome component required for packaging of DNA into chromatin; his-47 is a replication-dependent histone locus that resides in a histone gene-rich region on chromosome IV. B0035.8 B0035.8 Protein with high similarity to histone H2B (S. cerevisiae Htb1p), which binds chromatin, member of the histone family of nucleosomal core proteins histone H2B; his-48 encodes an H2B histone; by homology, HIS-48 is predicted to function as a nucleosome component required for packaging of DNA into chromatin; his-48 is a replication-dependent histone locus that resides in a histone gene-rich region on chromosome IV. B0035.9 B0035.9 Protein with very strong similarity to H4 histone family member E (human H4FE), which is a chromatin assembly complex component involved in the condensation of DNA into nucleosomes, member of the histone family of nucleosomal core proteins histone H4; his-46 encodes an H4 histone. B0041.1 B0041.1 Protein of unknown function B0041.2 B0041.2 Protein of unknown function, has low similarity to uncharacterized C. elegans C06G1.4 B0041.3 B0041.3 Protein containing a LysM domain, which may bind peptidoglycans B0041.4 rpl-1;B0041.4 Protein with high similarity to ribosomal protein L4 (rat Rpl4), which is a large 60S ribosomal subunit protein that binds 5S RNA and is involved in apoptosis, member of the ribosomal L4 or L1 family ribosomal protein L1; rpl-4 encodes a large ribosomal subunit L4 protein. B0041.5 B0041.5 Protein of unknown function, has weak similarity to uncharacterized S. pombe Spbc405.03cp B0041.6 B0041.6 Protein with high similarity to 6-pyruvoyltetrahydropterin synthase (mouse Pts), which catalyzes the second step in the biosynthesis of tetrahydrobiopterin, member of the 6-pyruvoyl tetrahydropterin synthase family 6-pyruvoyl tetrahydrobioterin synthase; B0041.6 is orthologous to the human gene 6-PYRUVOYLTETRAHYDROPTERIN SYNTHASE (PTS; OMIM:261640), which when mutated leads to disease. B0041.7 xnp-1;B0041.7 Protein containing a helicase conserved C-terminal domain and an SNF2 related N-terminal domain, has moderate similarity to a region of mouse Xnp, which may be a transcriptional regulator in DNA repair, DNA recombination, and neuronal differentiation helicase; xnp-1 is orthologous to the human gene ATR-X (OMIM:300032), which when mutated leads to ATR-X syndrome (OMIM:301040); xnp-1 is also homologous to human nibrin, which when mutated leads to Nigmegen breakage syndrome (OMIM:251260). B0041.8 B0041.8 Protein of unknown function B0047.1 B0047.1 Protein containing a meprin and TRAF homology (MATH) domain and a BTB (BR-C, ttk and babor) or POZ (Pox virus and zinc finger) domain, which may mediate protein-protein interactions, has moderate similarity to uncharacterized C. elegans R52.1 B0047.2 B0047.2 Protein containing a BTB (BR-C, ttk and babor) or POZ (Pox virus and zinc finger) domain, which are found in some DNA and actin binding proteins and may mediate protein-protein interactions, has high similarity to uncharacterized C. elegans F47C10.2 B0047.3 B0047.3 Protein containing a meprin and TRAF homology (MATH) domain and a BTB (BR-C, ttkand babor) or POZ (Pox virus and zinc finger) domain, which are found in some DNA and actin binding proteins, has high similarity to uncharacterized C. elegans F52C6.11 B0047.4 B0047.4 Protein containing a meprin and TRAF homology (MATH) domain B0047.5 B0047.5 Protein containing a meprin and TRAF homology (MATH) domain and a BTB (BR-C, ttk and babor) or POZ (Pox virus and zinc finger) domain, has high similarity to uncharacterized C. elegans F52C6.8 B0198.1 B0198.1 Member of the tetraspanin family, which contain an N-terminal transmembrane domain that is a signal sequence and membrane anchor, has low similarity to platelet endothelial tetraspan antigen 3 (human CD151), which mediates cell adhesion and cell migration tetraspanin B0198.2 B0198.2 Protein of unknown function B0198.3 B0198.3 Protein with high similarity to C. elegans MES-1, which is required for asymmetric divisions of the germline in early C. elegans embryos, contains two protein kinase domains protein kinase B0205.1 B0205.1 Protein of unknown function, has moderate similarity to uncharacterized C. elegans B0212.3 B0205.10 B0205.10 Protein of unknown function, has high similarity to uncharacterized C. elegans B0379.7 B0205.11 B0205.11 Protein of unknown function B0205.2 B0205.2 Member of an uncharacterized protein family 7TM chemoreceptor, srz family B0205.3 rpn-10;B0205.3 Protein with high similarity to proteasome 26S subunit non ATPase 4 (human PSMD4), which is an antisecretory factor that is a subunit of the 26S proteasome and may bind to multiubiquitinated proteins, contains two ubiquitin interaction motifs rpn-10 encodes a protein that contains two ubiquitin interaction motifs and is a member of the von Willebrand factor, type A superfamily similar to the mouse 26S proteasome non-ATP regulatory subunit 4. B0205.4 B0205.4 Member of the glycosyl transferase family 11, which hydrolyze the glycosidic bond between two or more carbohydrates, has a region of low similarity to a region of fucosyltransferase 2 (rat Fut2), which controls soluble blood group antigen synthesis The B0205.4 gene encodes a homolog of the human gene FUT1, which when mutated leads to leukocyte adhesion deficiency, type II (OMIM:266265). B0205.5 B0205.5 Protein of unknown function, has weak similarity to C. elegans Y18D10A.A B0205.6 B0205.6 Member of the cysteine desulfurase protein family aminotransferase B0205.7 B0205.7;CKIIalpha Casein kinase II, alpha subunit casein kinase; kin-3 encodes an ortholog of the catalytic subunit of casein kinase II alpha, which in Drosophila and mammals is required for normal circadian rhythms, and which directly phosphorylates the Drosophila PERIOD protein (which itself regulates circadian rhythms); by analogy, KIN-3 might be expected to help regulate heterochronic functions dependent on such proteins as LIN-42. B0205.8 B0205.8 Protein of unknown function B0205.9 B0205.9 Protein of unknown function, has high similarity to uncharacterized C. elegans B0212.3 B0207.1 B0207.1 Member of the protein-tyrosine phosphatase family, which are involved in cell growth control, proliferation, differentiation and transformation, has a region of low similarity to C. elegans F10G8.1, which is involved in embryogenesis or morphogenesis protein-tyrosine phophatase B0207.10 B0207.10 Protein of unknown function B0207.11 B0207.11 Protein of unknown function, has high similarity to uncharacterized C. elegans T08G11.2 B0207.12 avr-14;gbr-2;GluClX;B0207.12 Protein with high similarity to C. elegans GLC-1, which is an avermectin-sensitive glutamate-gated chloride channel GluCl-alpha subunit, contains five neurotransmitter-gated ion-channel ligand binding and six transmembrane domains avr-14 encodes an alpha-type subunit of a glutamate-gated chloride channel homologous to human GLRA2, which when mutated leads to hyperekplexia (OMIM:149400); AVR-14 affects sensitivity to the antiparisitic drug, ivermectin, in parallel with avr-15 and glc-1 and in a genetic pathway with unc-9; it functions in the extrapharyngeal nervous system, and is expressed in a subset of neurons in the ring ganglia, ventral cord, and some mechanosensory neurons. B0207.2 B0207.2 Protein of unknown function B0207.3 gpa-14;B0207.3 Member of the G protein alpha subunit family guanine nucleotide-binding protein, alpha subunit; gpa-14 encodes a member of the G protein alpha subunit family of heterotrimeric GTPases; gpa-14 is expressed in ASI, ASJ, ASH, ASK, ADE, PHA, PHB ALA, AVA, CAN, DVA, PVQ, RIA, and in vulval muscle, and also exhibits faint expression in the vulval hypodermis. B0207.4 air-2;let-603;B0207.4 Member of the aurora subfamily of serine/threonine protein kinases; associated with mitotic chromosomes; probably required for chromosome segregation, cytokinesis and polar body extrusion protein kinase; air-2 encodes an aurora/Ip11-related serine/threonine protein kinase that affects embryonic viability and chromosome segregation during meiosis and mitosis and is required for cytokinesis; AIR-2 has two functions during mitosis, one in chromosome segregation, and a second, independent function in cytokinesis through ZEN-4; AIR-2 and ZEN-4 may act in parallel to a second pathway that includes CYK-1; AIR-2 phosphorylates two adjacent, evolutionarily conserved C-terminal serines of the inner centromere protein ICP-1; AIR-2 forms a robust complex with CSC-1, BIR-1, and ICP-1; air-2 is expressed highly in embryos, in the mature oocytes, spermatocytes, and extruded polar bodies. B0207.5 B0207.5 Putative ortholog of C. elegans Y76G2B.C gene product B0207.6 B0207.6 Member of the conserved hypothetical ATP binding protein family, has low similarity to a region of XPA binding protein 1 (human NTPBP), which is a cytoplasmic GTPase that binds xeroderma pigmentosum group A protein (XPA) B0207.7 B0207.7 Protein containing a protein kinase domain, has low similarity to casein kinase 1 alpha 1 (human CSNK1A1), which is a serine-threonine protein kinase that may play a role in Alzheimer's disease serine/threonine-protein kinase B0207.8 B0207.8 Protein of unknown function B0207.9 B0207.9 Protein of unknown function B0212.1 B0212.1 Protein of unknown function, has moderate similarity to uncharacterized C. elegans F14B8.7 B0212.2 B0212.2 Member of the C. elegans Sre G protein-coupled chemoreceptor family, which are putative chemosensory receptors 7TM chemoreceptor, sre family B0212.3 B0212.3 Protein of unknown function, has high similarity to uncharacterized C. elegans M57.1 B0212.4 B0212.4 Protein containing two uncharacterized domains DUF6, has low similarity to solute carrier family 35 (UDP-N-acetylglucosamine(UDP-GlcNAc) transporter) member 3 (human SLC35A3), which transports nucleotide sugars B0212.5 osm-9;B0212.5 Predicted six transmembrane domain channel protein required for mechanosensation, AWA-mediated olfactory responses, AWC-mediated olfactory adaptation, and ASH-mediated avoidance responses olfacory channel; The osm-9 gene encodes a capsaicin receptor homolog involved in sensory responses to a subset of chemical stimuli and to ASH neuron-mediated osmotic and mechanical stimuli; OSM-9 is also involved in adaptation to volatile odorants and salts. B0213.1 B0213.1 TcA transposase B0213.10 B0213.10 Member of the cytochrome P450 family, has low similarity to cytochrome P450 2C18 (human CYP2C18), which non-stereospecifically catalyzes 4'-hydroxylation of (S)-mephenytoin and retinoic acid and metabolizes a variety of unrelated compounds and drugs cytochrome P450 B0213.11 B0213.11 Member of the cytochrome P450 family, has low similarity to nicotine C-oxidase (cytochrome P450 2A6) (human CYP2A6), which functions in oxidizing precarcinogens and drugs cytochrome P-450 B0213.12 B0213.12 Member of the cytochrome P450 family, has low similarity to cytochrome P450 2C18 (human CYP2C18), which catalyzes 4'-hydroxylation of (S)-mephenytoin and retinoic acid and metabolizes various compounds and drugs including anti-inflammatory agents cytochrome P450 B0213.14 B0213.14 Member of the cytochrome P450 family, has low similarity to cytochrome P450 2c29 (mouse Cyp2c29), which is a major cannabinoid metabolizing enzyme in liver microsomes and involved in detoxification of xenobiotics and drugs cytochrome P450 B0213.15 B0213.15 Member of the cytochrome P450 family, has low similarity to cytochrome P450 subfamily IIJ5 (mouse Cyp2j5), which is a heme-thiolate protein involved in the catalysis of NADPH-dependent oxidation of arachidonic acid to eicosanoids cytochrome P450 B0213.16 B0213.16 Member of the cytochrome P450 family, has low similarity to cytochrome P450 2c29 (mouse Cyp2c29), which is a major cannabinoid metabolizing enzyme in liver microsomes and involved in detoxification of xenobiotics and drugs cytochrome P-450 B0213.2 nlp-27;B0213.2 YGGWamide neurotransmitter nlp-27 encodes a predicted neuropeptide with homology to C. elegans nlp-28 through nlp-31. B0213.3 nlp-28;B0213.3 YGGWamide neurotransmitter B0213.4 nlp-29;B0213.4 YGGWamide neurotransmitter B0213.5 B0213.5 YGGWamide neurotransmitter nlp-30 encodes five predicted neuropeptide-like proteins; in C. elegans, nlp-30 is part of the YGGWamide neuropeptide family that also contains nlp-24, nlp-25, and nlp-27-32; nlp-30 is expressed in the hypodermis, suggesting that the peptides it encodes may have a non-neuronal function; as loss of nlp-30 activity via large-scale RNAi screens does not result in any obvious abnormalities, the precise role of the nlp-30-encoded peptides in development and/or behavior is not yet known. B0213.6 B0213.6 YGGWamide neurotransmitter nlp-31 encodes five predicted neuropeptide-like proteins; in C. elegans, nlp-31 is part of the YGGWamide neuropeptide family that also contains nlp-24, nlp-25, and nlp-27-32; nlp-31 is expressed in the hypodermis, suggesting that the peptides it encodes may have a non-neuronal function; nlp-31 expression is also detected in precomma-stage embryos; as loss of nlp-31 activity via large-scale RNAi screens does not result in any obvious abnormalities, the precise role of the nlp-31-encoded peptides in development and/or behavior is not yet known. B0213.7 B0213.7 Member of the 7-transmembrane chemoreceptor family of G protein-coupled receptors (GPCR), has weak similarity to C. elegans ODR-10, which is a G protein-coupled receptor involved in odorant response 7TM chemoreceptor, str family B0213.8 B0213.8 Member of the 7-transmembrane chemoreceptor family of G protein-coupled receptors (GPCR), has weak similarity to C. elegans ODR-10, which is a G protein-coupled receptor involved in odorant response 7TM chemoreceptor, str family B0213.9 B0213.9 Member of the 7-transmembrane chemoreceptor family of G protein-coupled receptors (GPCR), has low similarity to C. elegans ODR-10, which is a G protein-coupled receptor involved in odorant response 7TM chemoreceptor, str family B0218.1 B0218.1 Member of the amidase family, which catalyze hydrolysis of amides, has moderate similarity to fatty acid amide hydrolase (rat Faah), which is a serine hydrolase that degrades neuromodulatory fatty acid amides thereby terminating their signaling function amidase B0218.2 B0218.2 Member of the amidase family, which catalyze hydrolysis of amides, has moderate similarity to fatty acid amide hydrolase (rat Faah), which is a serine hydrolase that degrades neuromodulatory fatty acid amides thereby terminating their signaling function amidase B0218.3 pmk-1;B0218.3 Serine/threonine protein kinase of the MAP kinase subfamily ser/thr kinases; pmk-1 encodes a mitogen-activated protein kinase (MAPK), orthologous to human p38 MAPK (OMIM:600289), that is required for eliciting gonadal programmed cell death in response to Salmonella enterica infection; PMK-1 lies upstream of CED-9, a negative regulator of apoptosis, in the programmed cell death pathway. B0218.5 B0218.5 Protein containing two protein kinase domains, has low similarity to C. elegans KIN-19, which is a putative casein kinase 1 that regulates polarity of the EMS blastomere ser/thr kinase B0218.6 B0218.6 Member of the C-type lectin family, has similarity to human C-type mannose receptor MRC1, has similarity to D. melanogaster FW (furrowed) B0218.7 B0218.7 Protein of unknown function B0218.8 B0218.8 Member of the C-type lectin family, has similarity to human C-type mannose receptor MRC1 B0222.1 B0222.1 Protein containing a CX module domain, has high similarity to uncharacterized C. elegans F53C3.6 B0222.10 B0222.10 Protein of unknown function B0222.2 B0222.2 Member of the phosphate transporter family, has low similarity to amphotropic murine retrovirus receptor (solute carrier family 20 member 2, human SLC20A2), which is a sodium-dependent phosphate cotransporter that mediates inorganic phosphate transport phosphate permease B0222.3 B0222.3 Member of the phosphate transporter family, has moderate similarity to sodium inorganic phosphate cotransporter (solute carrier family 20 member 1, rat Slc20a1), which is a high-affinity sodium-inorganic phosphate cotransporter phosphate permease B0222.4 B0222.4 Protein containing two pyridoxal-dependent group II decarboxylase conserved domains, which bind pyridoxal-phosphate groups, has moderate similarity to sphingosine phosphate lyase 1 (mouse Sgpl1), which cleaves the C2-3 carbon of sphingosine phosphate glutamate decarboxylase B0222.5 B0222.5 Protein containing a thyroglobulin type-1 repeat, which may be involved in the control of proteolytic degradation, and a kunitz or bovine pancreatic trypsin inhibitor domain B0222.6 B0222.6 Protein containing two collagen triple helix repeats, which are found in some extracellular proteins, and a nematode cuticle collagen N-terminal domain, has moderate similarity to a region of C. elegans BLI-1 B0222.7 B0222.7 Protein containing two collagen triple helix repeats, which are found in some extracellular proteins, and a nematode cuticle collagen N-terminal domain, has high similarity to a region of C. elegans BLI-1 B0222.8 col-10;B0222.8 Putative collagen B0222.9 B0222.9 Protein containing one molybdopterin binding, one [2Fe-2S] binding, one a-b hammerhead, and one 2Fe-2S iron-sulfur cluster binding domain, has low similarity to xanthine dehydrogenase (rat Xdh), which converts xanthine to uric acid in purine catabolism xanthine dehydrogenase B0228.1 B0228.1 Protein of unknown function B0228.2 B0228.2 Protein of unknown function, has a region of low similarity to a region of copine III (human CPNE3), which has protein kinase activity and may play a role in membrane trafficking B0228.3 B0228.3 Putative coiled-coil protein, has weak similarity to C. elegans T06D8.1 protein B0228.4 B0228.4 Putative coiled-coil protein, has weak similarity to human EEA1 (early endosome-associated), has weak similarity to C. elegans F12F3.3, has weak similarity to C. albicans Met3p, ATP sulfurylase B0228.5 B0228.5 Member of the thioredoxin family, which are small enzymes involved in redox reactions, has moderate similarity to thioredoxin (human TXN), which has dithiol-disulfide oxidoreductase activity and promotes neutrophil migration Thioredoxin I; This gene encodes a protein predicted by Eisenberg and coworkers, with 52% accuracy, to be mitochondrial. B0228.6 B0228.6 Protein of unknown function B0228.7 B0228.7 Protein with high similarity to methylthioadenosine phosphorylase (human MTAP), which catalyzes phosphorolytic cleavage of 5'-methylthioadenosine in purine and methionine salvage pathways, member of the purine phosphorylases family 2 B0228.8 B0228.8 Protein of unknown function, has weak similarity to C. elegans B0228.9 B0228.9 B0228.9 Protein of unknown function, has weak similarity to C. elegans B0228.8 B0238.1 B0238.1 Member of the carboxylesterase type B family, has low similarity to carboxylesterase 1 (monocyte-macrophage serine esterase 1, rat Ces1), which is a liver esterase carboxylesterase B0238.10 B0238.10 Protein with strong similarity to S. cerevisiae Mak3p, a protein N-acetyltransferase that acetylates the N-terminus of L-A virus GAG protein acyltransfersase B0238.11 B0238.11 Protein of unknown function B0238.12 B0238.12 Protein containing two trypsin inhibitor-like cysteine rich domains, has moderate similarity to uncharacterized C. elegans C25E10.9 B0238.13 B0238.13 Member of the carboxylesterase type B family, has a region of low similarity to carboxylesterase 1 (monocyte-macrophage serine esterase 1, rat Ces1), which is a liver esterase carboxylesterase B0238.3 B0238.3 Protein of unknown function, has high similarity to uncharacterized C. elegans B0238.4 7TM chemoreceptor, srt family B0238.4 B0238.4 Protein of unknown function, has high similarity to uncharacterized C. elegans B0238.3 B0238.5 B0238.5 Protein of unknown function, has high similarity to uncharacterized C. elegans B0238.3 7TM chemoreceptor, srt family B0238.6 B0238.6 Protein of unknown function, has high similarity to uncharacterized C. elegans B0238.8 7TM chemoreceptor, srt family B0238.7 B0238.7 Member of the carboxylesterase type B family, has low similarity to butyrylcholinesterase (mouse Bche) carboxylesterase B0238.8 B0238.8 Protein of unknown function, has high similarity to uncharacterized C. elegans B0238.6 7TM chemoreceptor, srt family B0238.9 B0238.9 Protein of unknown function B0240.1 rhr-2;B0240.1 Member of the ammonium transporter family of membrane transporters, has moderate similarity to rhesus glycoprotein type C (human RHCG), which is an ammonium transporter that is expressed in nonerythroid tissues erythrocyte plasma membrane glycoprotein like; rhr-2 encodes a predicted transmembrane protein with similarity to human Rh blood group antigens proposed to function in inorganic ion transport and metabolism; the role of RHR-2 in C. elegans development or behavior remains unclear, as loss of RHR-2 function via RNA-mediated interference does not result in any abnormalities. B0240.2 B0240.2 Protein of unknown function B0240.3 daf-11;B0240.3 A guanylate cyclase that is involved in chemosensation and dauer formation guanylate cyclase; The daf-11 gene encodes a guanylate cyclase that affects dauer formation, chemotaxis, and axon formation; it is genetically upstream of daf-12 with respect to dauer larvae formation and is expressed in a subset of amphid neurons. B0244.10 B0244.10 Putative ortholog of C. elegans B0244.6 gene product B0244.11 B0244.11 Protein of unknown function B0244.2 ida-1;ia2;B0244.2 Putative receptor-type tyrosine protein phosphatase-like protein, component of neurosecretory cell dense core vesicles, ortholog of human PTPRN and PTPRN2 protein tyrosine phosphatase; ida-1 encodes a protein tyrosine phosphatase-like receptor, orthologous to the mammalian type I diabetes autoantigens IA-2 and phogrin that are expressed in dense core vesicles of neuroendocrine tissue and involved in regulated protein secretion; in C. elegans, IDA-1 appears to be required for regulating presynaptic neurotransmission and in particular, for the neuropeptidergic control of egg-laying; ida-1 interacts genetically with unc-31 and unc-64, which encode proteins required for dense core vesicle fusion and exocytosis; ida-1 expression is detected in a subset of neurons in the anterior nerve ring, the ventral nerve cord, the tail, and the vulva, including the VC vulval motoneurons and the HSN egg-laying neurons; ida-1 is also detected in the vulval uv1 cells, non-neuronal cells that contain neurosecretory-like vesicles. B0244.3 B0244.3 Protein of unknown function B0244.4 B0244.4 Protein with strong similarity to C. elegans B0244.5 gene product B0244.5 B0244.5 Protein with strong similarity to C. elegans B0244.4 gene product B0244.6 B0244.6 Member of the rhodopsin family of G protein-coupled receptors (GPCR) B0244.7 B0244.7 Member of the rhodopsin family of G protein-coupled receptors (GPCR), has weak similarity to uncharacterized C. elegans ZK418.7 B0244.8 B0244.8 Protein containing seven low-density lipoprotein receptor class A domains, has low similarity to a region of low density lipoprotein receptor-related protein 1B (human LRP1B), which is involved in endocytosis and associated with lung cancer LDL receptor B0244.9 B0244.9 Protein of unknown function B0250.1 B0250.1 Protein with high similarity to ribosomal protein L2 (S. cerevisiae Rpl2Bp), which is part of the large ribosomal subunit, member of the ribosomal L2 family Ribosomal Proteins L2; rpl-2 encodes a large ribosomal subunit L8 protein. B0250.2 B0250.2 Protein of unknown function B0250.4 B0250.4 Protein with moderate similarity to C. elegans R07E5.5 gene product B0250.5 B0250.5 Protein with high similarity to 3-hydroxyisobutyrate dehydrogenase (rat HIBADH), which catalyzes the NAD-dependent oxidation of 3-hydroxbutyrate to methylmalonate in valine catabolism 3-HYDROXYISOBUTYRATE DEHYDROGENASE PRECURSOR (EC 1.1.1.31) (HIBADH) (FRAGMENT); This gene encodes a protein predicted by Eisenberg and coworkers, with 52% accuracy, to be mitochondrial. B0250.6 B0250.6 Protein containing a DUF40 domain of unknown function, which contain four conserved cysteines, has high similarity to uncharacterized C. elegans M01B2.3 7TM receptor, srbc family B0250.7 B0250.7 Member of the ribosomal L2 family, which are part of the large ribosomal subunit, has a region of strong similarity to a region of C. elegans B0250.1, which is a protein involved in embryogenesis and morphogenesis Ribosomal Proteins L2 B0250.8 B0250.8 Protein with moderate similarity to C. elegans K09H9.6 gene product B0250.9 B0250.9 Member of the ergosterol biosynthesis family, which includes reductases and anchor proteins, contains a DUF40 domain, which contain four conserved cysteines, has a region of low similarity to 7-dehydrocholesterol reductase (human DHCR7) sterol reductase; B0250.9 is orthologous to the human gene 7-DEHYDROCHOLESTEROL REDUCTASE (DHCR7; OMIM:602858), which when mutated leads to disease. B0252.1 B0252.1 Protein containing a protein kinase domain, has a region of low similarity to a region of C. elegans DAF-2, which is a transcription factor involved in fertilization, gametogenesis, and response to UV Tyrosine-protein kinase B0252.2 asm-1;B0252.2 Acid sphingomyelinase Spingomyelin phosphodiesterase B0252.3 B0252.3 Member of the sugar (and other) transporter family, has low similarity to solute carrier family 22 (organic cation transporter) member 2 (human SLC22A2) B0252.4 cyp-10;B0252.4 Cyclophilin-related peptidylprolyl cis-trans-isomerase Cyclophilin; cyp-10 encodes a divergent cyclophilin isoform that is functional when expressed in E. coli. B0252.5 B0252.5 Protein of unknown function B0252.6 B0252.6 Protein of unknown function, has weak similarity to C. elegans T22B11.1 B0261.1 B0261.1 Protein containing one Myb-like DNA-binding domain B0261.2 Ce-tor;B0261.2 Protein containing two phosphatidylinositol 3- and 4-kinase domains, two FATC (FRAP, ATM, TRRAP C-terminal) domains, and a FAT (FRAP, ATM and TRRAP) domain, has moderate similarity to FK506 binding protein 12-rapamycin associated protein 1 (human FRAP1) kinase; let-363 encodes, by alternative splicing, two large (>2600-residue) proteins with C-terminal similarity to phosphatidylinositol kinase (PIK); LET-363 proteins are orthologous to S. cerevisiae Tor1p and Tor2p and human FRAP1 (OMIM:601231, mammalian target of FKBP12-rapamycin); LET-363 proteins are required for progression through the L3 stage of larval development and are thought to generally stimulate translation of most or all mRNAs ('global translation'); LET-363 activity is also necessary for normal development and physiology of the intestine; LET-363 proteins are expressed ubiquitously, including a maternal contribution to the early embryo. B0261.4 B0261.4 Possible large ribosomal subunit protein B0261.5 B0261.5 Protein of unknown function B0261.6 B0261.6 Protein of unknown function, has similarity to C. elegans TLF B0261.7 B0261.7 Protein of unknown function, has low similarity to uncharacterized C. elegans C36B1.11 B0272.1 B0272.1 Protein with strong similarity to C. elegans MEC-7, which is a beta tubulin expressed specifically in touch receptor neurons, member of the tubulin-FtzA family, which are involved in polymer formation tubulin beta chain B0272.2 B0272.2 Protein with low similarity to membrin (rat Gosr2), which regulates vesicle transport, docking, and fusion, and functions in intracellular transport of proteins between the ER and Golgi B0272.3 B0272.3 Protein with high similarity to short chain L-3-hydroxyacyl-coenzyme A (human HADHSC), which catalyzes the penultimate step in fatty acid beta oxidation, contains 3-hydroxyacyl-CoA dehydrogenase NAD binding domain and C-terminal domains 3-hydroxyacyl-CoA dehydrogenase B0272.4 B0272.4 Member of the enoyl-coA hydratase or isomerase protein family, has moderate similarity to peroxisomal D3,D2-enoyl-CoA isomerase (human PECI), which catalyzes an isomerization step in the beta oxidation of fatty acids enoyl-CoA hydratase/isomerase B0272.5 B0272.5 Protein containing several filamin (ABP120) or Dictyostelium gelation factor (ABP280) repeat domains, which are found in actin-binding proteins, has weak similarity to a region of filamin A (filamin alpha, human FLNA), which mediates actin crosslinking B0273.1 B0273.1 Protein of unknown function, has high similarity to uncharacterized C. elegans B0334.10 B0273.2 puf-7;B0273.2 Protein containing six Pumilio-family (Puf) RNA binding domains, has moderate similarity to a region of C. elegans FBF-2, which is an RNA-binding protein involved in sex determination puf-7 encodes a protein 97% identical to PUF-6 and functions redundantly with the other PUF genes, fbf-1, fbf-2, puf-6, and puf-8, during primordial germ cell development, based on combinatorial RNAi; interacts with NOS-2 in yeast two-hybrid screens. B0273.3 B0273.3 Protein of unknown function, has a region of low similarity to a region of small nuclear RNA activating complex polypeptide 3 50kD (human SNAPC3), which is a DNA binding subunit of SNAPc complex B0273.4 unc-5;B0273.4 Type 1 transmembrane receptor expressed on the surface of axon growth cones and motile mesodermal cells to guide dorsal-specific movement, member of the immunoglobulin superfamily axon guidance protein; The unc-5 gene encodes a netrin receptor required to guide cellular and axonal migrations along the body wall. B0280.1 B0280.1 Protein with high similarity to rat Rabggtb, which is the beta subunit of the geranylgeranyl transferase that transfers geranylgeranyl groups to C-terminal cysteines on Rab proteins, contains fifteen prenyltransferase and squalene oxidase repeat domains prenyltransferase BET2 B0280.10 B0280.10 Protein of unknown function B0280.11 B0280.11 Protein containing a C-terminal KH domain involved in RNA binding, has weak similarity to tyrosine protein phosphatases Tyrosine-phosphatase B0280.12 glr-2;B0280.12 Member of the ligand-gated ion channel protein family Glutamate receptor; glr-2 encodes an AMPA (non-NMDA)-type ionotropic glutamate receptor subunit; GLR-2 activity is required for mediating the behavioral response to light nose touch and for regulating the frequency with which animals change locomotory direction in response to sensory cues such as food; GLR-2 and GLR-1, a second AMPA-type ionotropic glutamate receptor, can interact to form functional heteromeric channels; GLR-2 is expressed in many neurons, including four of the five pairs of command interneurons that are required for locomotory control. B0280.2 B0280.2 Protein containing two wasp homology 1 (WH1) domains B0280.3 B0280.3;nhr-10 Protein with high similarity to ribose 5-phosphate isomerase A (mouse Rpia), which converts ribose 5-phosphate to ribulose 5-phosphate and acts in the pentose phosphate cycle B0280.4 B0280.4 Protein containing three C2H2 type zinc finger domains, which bind nucleic acids, has a region of moderate similarity to a region of zinc finger protein 234 (human ZNF234), which is a Kruppel-related zinc-finger transcriptional corepressor odd-1 encodes a C2H2-type zinc finger-containing transcription factor similar to Drosophila odd skipped which is required for embryonic patterning; ODD-1 is expressed in the gut during embryogenesis and appears to be essential for larval development. B0280.5 B0280.5 Protein containing six chitin binding peritrophin-A domains, has a region of low similarity to a region of C. elegans CEJ-1, which is a possible cell junction protein B0280.5 encodes a protein with a chitin binding peritrophin-A domain that is required, in conjunction with CEJ-1, for early embryonic development; B0280.5 mRNA is expressed specifically in the adult hermaphrodite germ line, is a direct target of GLD-1, and has an RNAi phenotype consistent with the hypothesis that B0280.5 is an effector of GLD-1 in the germline. B0280.7 B0280.7 Protein with moderate similarity to C. elegans F25E2.2 gene product B0280.8 nhr-10;B0280.8 Protein containing a nuclear hormone receptor ligand-binding domain and a C4-type zinc finger domain, which bind DNA and may be involved in transcription regulation, has low similarity to hepatic nuclear factor 4 (mouse Hnf4) retinoic acid; nhr-10 encodes a predicted nuclear hormone receptor diverged from nuclear hormone receptors in other phyla; its mRNA is expressed throughout development with possibly lower expression from the L4 larval to adult stages, and the protein is expressed in neuronal processes. B0280.9 B0280.9 Protein containing three WD domains (WD-40 repeat), which may mediate protein-protein interactions, has low similarity to uncharacterized CGI-48 protein (human LOC51096) B0281.1 B0281.1 Protein with moderate similarity to C. elegans B0281.8 gene product B0281.2 B0281.2 Member of the reverse transcriptase protein family, which are RNA-dependent DNA polymerases, has high similarity to uncharacterized C. elegans B0302.6 B0281.3 B0281.3 Protein of unknown function, has high similarity to uncharacterized C. elegans K09F6.7 B0281.4 B0281.4 Protein containing a K+ channel tetramerization domain, which facilitate assembly of alpha-subunits into functional tetrameric channels, has high similarity to uncharacterized C. elegans B0281.5 B0281.5 B0281.5 Protein containing a K+ channel tetramerization domain, which facilitate assembly of alpha-subunits into functional tetrameric channels, has high similarity to uncharacterized C. elegans C40A11.6 B0281.6 B0281.6 Protein containing a K+ channel tetramerization domain, which facilitate assembly of alpha-subunits into functional tetrameric channels, has high similarity to uncharacterized C. elegans C40A11.7 B0281.8 B0281.8 Protein containing a C3HC4 type Ring zinc finger, which may mediate protein-protein interactions, has high similarity to uncharacterized C. elegans ZK1240.5 B0284.1 B0284.1 Protein of unknown function, has moderate similarity to uncharacterized C. elegans B0284.2 B0284.2 B0284.2 Protein of unknown function, has moderate similarity to uncharacterized C. elegans B0284.4 B0284.3 B0284.3 Protein of unknown function B0284.4 B0284.4 Protein of unknown function, has moderate similarity to uncharacterized C. elegans B0284.2 B0285.1 B0285.1 Protein containing a protein kinase domain, has a region of moderate similarity to cyclin-dependent kinase 9 (CDC2-related kinase, mouse Cdk9), which is a serine-threonine kinase expressed maximally during muscle and neural cell terminal differentiation serine/threonine kinase (CDC2/CDKX subfamily) B0285.10 B0285.10 Member of the choline or ethanolamine kinase family, which catalyze formation of phosphatidylcholine by the CDP-choline pathway, has low similarity to a region of choline-ethanolamine kinase (rat Chkl), which is involved in phosphatidylcholine synthesis choline kinase B0285.3 B0285.3 Protein of unknown function B0285.4 B0285.4 Putative leucine carboxyl methyltransferase, has similarity to human LCMT B0285.5 B0285.5 Protein of unknown function hse-5 encodes a D-glucuronyl C5-epimerase. B0285.6 B0285.6 Member of the Sodium:sulfate symporter family of membrane transporters, has moderate similarity to solute carrier family 13 (sodium-dependent dicarboxylate transporter) member 3 (rat Nadc3), which acts in di- and tri-carboxylic acid transport Yeast ORF YCS7_YEAST B0285.7 B0285.7 Member of the M1 peptidase family of aminopeptidases Aminopeptidase B0285.8 B0285.8 Member of the choline or ethanolamine kinase family, which catalyze the formation of phosphatidylcholine by the CDP-choline pathway, has low similarity to a region of choline kinase (human CHK), which catalyzes the first step in the CDP-choline pathway choline kinase B0285.9 B0285.9 Member of the choline or ethanolamine kinase family, which catalyze the formation of phosphatidylcholine by the CDP-choline pathway, has low similarity to choline-ethanolamine kinase (rat Chkl), which is involved in phosphatidylcholine biosynthesis choline kinase B0286.1 B0286.1 Protein of unknown function B0286.2 B0286.2 Protein with similarity to a human leukocyte transmembrane protein, CD97beta, member of the C-type lectin family lat-2 encodes a predicted transmembrane protein that is homologous to vertebrate latrophilins, alpha-latrotoxin binding proteins that are members of the Class B/secretin family of G protein-coupled receptors; by homology, LAT-2 is predicted to function as a peptide hormone receptor that couples ligand binding to heterotrimeric G protein-mediated stimulation of secretion; lat-2 is expressed in the g1 gland cells and in the arcade cells in the head, and its expression has been reported to cycle with larval molts; as loss of lat-2 activity via large-scale RNAi screens does not result in any obvious abnormalities, the precise role of LAT-2 in C. elegans development and/or behavior is not yet known. B0286.3 B0286.3 Member of 1-(5-phosphoribosyl)-5-amino-4-imidazole-carboxylate (AIR) carboxylase and SAICAR (phosphoribosylaminoimidazole-succinocarboxamide) synthetase families, has high similarity to uncharacterized SAICAR synthetase and AIR carboxylase (rat Ade2h1) saicar synthetase/air carboxlyase; This gene encodes a protein predicted by Eisenberg and coworkers, with 52% accuracy, to be mitochondrial. B0286.4 B0286.4 Protein of unknown function, has moderate similarity to a region of carbon catabolite repressor negative regulator of transcription complex subunit 2 (human CNOT2), which is a component of the CCR4-NOT global transcriptional regulator complex B0286.5 B0286.5 Protein containing a fork head domain, which are found in transcription factors involved in cell fate determination, has a region of moderate similarity to a region of forkhead box I1 (human FOXI1), which is a transcriptional activator fork head DNA-binding protein; fkh-6 encodes a protein which belongs to the forkhead family of transcription factors; fkh-6 is required for several aspects of male gonadogenesis including asymmetric cell division, cell migration and sex determination and appears to act downstream of tra-1; FKH-6 is specifically expressed in the gonad. B0294.1 B0294.1 Protein of unknown function, has high similarity to uncharacterized C. elegans C12D5.3 B0294.2 B0294.2 Protein with strong similarity to C. elegans B0294.1 gene product B0294.3 B0294.3 Protein of unknown function, has moderate similarity to C. elegans T28A11.21 This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins. B0302.1 kin-25;Cehd-20;B0302.1 Putative tyrosine protein kinase, has similarity to human p21cdc42 protein kinase that inhibits p21cdc42, has similarity to D. melanogaster SRC-related proteins protein tyrosine kinase; Expression experimentally verified by RT-PCR. B0302.2 B0302.2 Protein of unknown function B0302.3 B0302.3 Member of the reverse transcriptase protein family, which are RNA-dependent DNA polymerases, has very strong similarity to uncharacterized C. elegans T06C10.5 reverse transcriptase B0302.4 B0302.4 Protein of unknown function B0302.5 B0302.5 Protein of unknown function tyrosine-protein kinase B0302.6 B0302.6 Member of the reverse transcriptase protein family, which are RNA-dependent DNA polymerases, has high similarity to uncharacterized C. elegans F22B3.3 reverse transcriptase B0303.11 B0303.11 Protein with moderate similarity to human sodium/potassium/chloride transporters B0303.14 B0303.14 Protein of unknown function Giant secretory protein I-C B0303.15 B0303.15 Protein containing a ribosomal L11 domain, which are present in the large ribosomal subunit, has low similarity to S. cerevisiae Mrpl19p, which is a mitochondrial ribosomal protein of the large subunit Ribosomal protein L11; This gene encodes a protein predicted by Eisenberg and coworkers, with 52% accuracy, to be mitochondrial. B0303.2 B0303.2 Member of the NNMT, PNMT or TEMT family of methyltransferases, has low similarity to nicotinamide N-methyltransferase (human NNMT), which transfers S-adenosyl L-methionine methyl groups to nicotinamide, pyridines, structurally-related drugs, xenobiotics B0303.3 B0303.3 Protein with high similarity to 3-hydroxyacyl-CoA dehydrogenase (human HADHB), which is the 3-ketoacyl-CoA thiolase trifunctional protein beta subunit that is involved in fatty acid beta-oxidation, contains thiolase N-terminal and C-terminal domains Acetyl-coa acetyltransferase; B0303.3 is orthologous to the human gene 3-KETOACYL-COA THIOLASE BETA-SUBUNIT OF TRIFUNCTIONAL PROTEIN (HADHB; OMIM:143450), which when mutated leads to disease. B0303.4 B0303.4 Member of the ubiquitin family B0303.5 B0303.5 Member of the Tc3 Transposase protein family transposase B0303.7 B0303.7 Protein containing three Src homology 3 (SH3) domains, which bind proline-rich peptides, has a region of low similarity to a region of arg binding protein 2 (human ARGBP2), which may act as a cytoskeletal adaptor protein Neutrophil oxidase factor B0303.8 B0303.8 Protein of unknown function, has weak similarity to C. elegans T11A5.5 B0303.9 slp-1;B0303.9 Member of the Sec1 family, which may be involved in secretion, has low similarity to vacuolar sorting protein 33a (rat Vps33a) SLP-1 B0304.1 hlh-1;CeMyoD;B0304.1 Protein involved in specification of muscle cell fates; member of the Helix-loop-helix DNA-binding Domain protein family helix-loop-helix transcription factor; hlh-1 is orthologous to the human gene MYOGENIC FACTOR 6 (HERCULIN) (MYF6; OMIM:159991), which when mutated leads to disease. B0304.2 B0304.2 Protein of unknown function B0304.3 B0304.3 Member of the cytochrome P450 family, has low similarity to cytochrome P450 subfamily IIJ5 (mouse Cyp2j5), which is a heme-thiolate protein involved in the catalysis of NADPH-dependent oxidation of arachidonic acid to eicosanoids Cytochrome P450; The B0304.3 gene encodes a homolog of the human gene CYP7B1, which when mutated leads to giant cell hepatitis (OMIM:231100). B0304.4 B0304.4 Protein of unknown function B0304.5 B0304.5 Member of C. elegans Sra integral membrane protein family, which contain 6-7 hydrophobic, putative transmembrane, regions 7TM chemoreceptor, sra family B0304.6 B0304.6 Member of C. elegans Sra integral membrane protein family, which contain 6-7 hydrophobic, putative transmembrane, regions, has low similarity to uncharacterized C. elegans SRA-10 7TM chemoreceptor, sra family B0304.7 B0304.7 Member of C. elegans Sra integral membrane protein family, which contain 6-7 hydrophobic, putative transmembrane, regions 7TM chemoreceptor, sra family B0310.1 B0310.1 Protein with weak similarity to calcium channel proteins, has weak similarity to human KCNK1 and KCNK5, has weak similarity to C. elegans TWK-3 B0310.2 B0310.2 Protein containing two C2H2 type zinc finger domains, which bind nucleic acids, has a region of moderate similarity to a region of KRAB zinc finger suppressor protein 1 (rat Rn.11374), which acts as a transcriptional repressor C2H2-type zinc fingers B0310.3 B0310.3 Protein of unknown function B0310.4 B0310.4 Protein of unknown function, has high similarity to uncharacterized C. elegans Y54B9A.1 repetitive proline-rich cell wall protein B0310.5 B0310.5 Protein containing two UDP-glucoronosyl and UDP-glucosyl transferase domains, which transfer glycosyl groups to small hydrophobic molecules, has weak similarity to UDP glycosyltransferase 1 A3 (human UGT1A3), which plays a role in drug metabolism UDP galactosyltransferase B0310.6 B0310.6 Protein of unknown function B0331.1 B0331.1 Member of the cytochrome P450 family, has low similarity to cytochrome P450 subfamily 4A polypeptide 11 fatty acid omega-hydroxylase (rat Cyp4a11), which hydroxylates steroids, fatty acids, and xenobiotics and is involved in blood pressure regulation cytochrome P450 B0331.2 B0331.2 Member of the phosphate transporter family, has weak similarity to sodium inorganic phosphate cotransporter (solute carrier family 20 member 1, rat Slc20a1), which is a high-affinity sodium-inorganic phosphate cotransporter phosphate permease like B0334.1 B0334.1 Member of the transthyretin-like family, has high similarity to uncharacterized C. elegans R90.2 Transthyretin-like family B0334.10 B0334.10 Protein of unknown function, has high similarity to uncharacterized C. elegans B0273.1 B0334.11 ooc-3;B0334.11 Protein involved in the establishment of cell and embryonic polarity and morphogenesis ooc-3 encodes a nematode-specific protein with a predicted signal sequence, four predicted transmembrane domains, and two putative PEST sequences; OOC-3 is probably localized to the endoplasmic reticulum (ER), and is maternally required for correct localization of PAR-2 and PAR-3 in the P1 blastomere of the two-cell stage embryo; specifically, OOC-3 is required for restricting PAR-3 to the anterior cortex of the P1 blastomere to assure PAR-2 localization at the posterior cortex; more generally, OOC-3 is required to establish asymmetrical anterior-posterior cortical domains and spindle orientation in P1. B0334.2 twk-1;B0334.2 Member of the 4 TM potassium channel protein family potassium channel protein; twk-5 encodes one of 44 C. elegans TWK (two-P domain K+) potassium channel subunits that contain two pore-forming domains and four transmembrane domains; as loss of TWK-5 function via RNA-mediated interference (RNAi) does not result in any abnormalities, the precise role of TWK-5 in C. elegans development and/or behavior is not yet known; TWK-5 may, however, function redundantly with other TWK channels; the TWK-5 expression pattern is not yet known. B0334.3 B0334.3;B0334.3 Member of the decarboxylase (tentative) protein family Thiamine pyrophosphate enzymes B0334.4 B0334.4 Protein of unknown function, has low similarity to uncharacterized PX19-like protein (human PX19), which may have a role in B lymphocyte development and is predominantly expressed in germinal centers Yeast hypothetical protein L8167.12 like B0334.5 B0334.5 Protein of unknown function phytoene synthase precursor B0334.6 B0334.6 Member of the rhodopsin family of G protein-coupled receptors (GPCR) Gonadotropin-releasing hormone receptor like protein B0334.7 B0334.7 Member of the 7-transmembrane chemoreceptor family of G protein-coupled receptors (GPCR), has low similarity to uncharacterized C. elegans W02H5.6 B0334.8 age-1;daf-23;B0334.8 Signal transduction protein of the phosphatidylinositol-3-OH kinase (PI(3)K) family; involved in control of multiple processes including dauer larva formation, longevity, fertility, thermotolerance, and adult motility phosphatidylinositol 3-kinase; age-1 encodes the C. elegans ortholog of the phosphatidylinositol-3-kinase p110 catalytic subunit; AGE-1, supplied maternally and embryonically, is a central component of the C. elegans insulin-like signaling pathway, lying downstream of the DAF-2/insulin receptor and upstream of both the PDK-1 and AKT-1/AKT-2 kinases and the DAF-16 forkhead type transcription factor, whose negative regulation is the key output of the insulin signaling pathway; in accordance with its role in insulin signaling, AGE-1 activity is required for regulation of metabolism, life span, dauer formation, stress resistance, fertility, and embryonic development; although the age-1 expression pattern has not yet been reported, ectopic expression studies indicate that pan-neuronal age-1 expression is sufficient to rescue life-span defects, while neuronal, intestinal, or muscle expression can partially rescue dauer formation, and neuronal or muscle expression can rescue metabolic defects. B0334.9 B0334.9 Protein with strong similarity to C. elegans F16B12.6 gene product B0336.1 wrm-1;B0336.1 Beta-catenin-related protein required for establishment of embryonic polarity; member of a divergent Wnt signaling pathway B0336.10 B0336.10 Protein with high similarity to ribosomal protein L23 (S. cerevisiae Rpl23bp), which is a structural ribosomal protein, member of the ribosomal L14p or L23e family, which are part of the large ribosomal subunit and may bind rRNA rpl-23 encodes a large ribosomal subunit L23 protein. B0336.11 B0336.11 Protein containing a major sperm protein (MSP) domain, which are involved in sperm motility B0336.12 B0336.12 Protein of unknown function B0336.13 B0336.13 Protein with strong similarity to C. elegans Y111B2A.13 gene product B0336.2 arf-1;B0336.2 Protein with strong similarity to ADP-ribosylation factor 1 (human ARF1), which is a small guanine nucleotide-binding protein that plays a role in vesicular transport, member of the ADP-ribosylation factor (ARF) family ARF; arf-1 encodes an ADP-ribosylation factor homolog required in vivo for embryonic development, fertility, locomotion, vulval development, and cuticular synthesis; ARF proteins are N-myristoylated GTPases that regulate membrane traffic and the actin cytoskeleton, and that activate both phospholipase D1 (PLD1) and phosphatidylinositol 4-phosphate 5-kinase. B0336.3 B0336.3 Protein containing a CCCH-type zinc finger domain, which bind DNA or RNA B0336.4 rgs-5;B0336.4 Protein of unknown function, has a region of low similarity to a kinase anchor protein 10 (mouse Akap10), which interacts with type I and type II regulatory subunits of cAMP-dependent protein kinase and anchors the kinase near its physiological substrates rgs-5 encodes a regulator of G protein signaling; by homology, RGS-5 is predicted to function as a GTPase-activating protein that binds G protein alpha subunits and negatively regulates heterotrimeric G protein signaling; loss of rgs-5 activity via RNAi or a deletion mutation results in no obvious defects, and likewise, rgs-5 overexpression has no measurable effect on egg-laying behavior, locomotion, or viability; an rgs-5 transcriptional reporter is expressed in head neurons in larvae and adults. B0336.5 B0336.5 Member of the TFIIA small subunit protein family B0336.6 B0336.6 Protein containing a Src homology 3 (SH3) domain, has moderate similarity to spectrin SH3 domain binding protein 1 (human SSH3BP1), which interacts with the SH3 domains of human EPS8, human ABL1, and spectrin (human SPTA1) and is involved in endocytosis B0336.6 encodes an Abl interactor ortholog, with an SH3 domain, required for embryonic development; mammalian Abl interactors are associated with synaptosomes, growth cone particles, and macropinocytic vesicles, and may regulate Rac-dependent cytoskeletal reorganization and Abl kinase activity; B0336.6's orthologs include human SSH3BP1 (ABI1; OMIM:603050, mutated in acute myeloid leukemia), ABI-2 (OMIM:606442), and NESH (OMIM:606363); B0336.6 binds UNC-53 in two-hybrid screens. B0336.7 B0336.7 Protein of unknown function B0336.8 B0336.8 Protein of unknown function, has low similarity to uncharacterized autophagy 12-like (human APG12L) lgg-3 encodes a hydrophilic protein that is orthologous to Saccharomyces cerevisiae autophagy protein Apg12p; by homology, LGG-3 is predicted to function as a modifier protein required for a protein conjugation system essential for autophagy; in the context of this conjugation system, LGG-3 is predicted to interact with Apg7p and Apg5p homologs (encoded by M7.5 and Y71G12B.12a, respectively) to effect bulk degradation of cytoplasmic components under conditions of starvation or cellular remodeling; free LGG-3 is predicted to localize to the cytoplasm, while LGG-3 conjugated to the Apg5p homolog is predicted to associate with membrane compartments; loss of lgg-3 activity via large-scale RNAi screens results in no obvious developmental or behavioral abnormalities. B0336.9 swp-1;CeSWAP;B0336.9 Putative splicing regulator and member of the SWAP protein family swp-1 encodes a protein containing two SWAP (Suppressor-of-White-APricot splicing regulator) domains that have been implicated in RNA binding; orthologous to C. briggsae CBG09000. B0344.2 B0344.2 Protein with strong similarity to C. elegans wrt-1 gene product B0348.1 B0348.1 Protein of unknown function, has moderate similarity to uncharacterized C. elegans Y37D8A.8 B0348.2 B0348.2 Protein with strong similarity to C. elegans B0348.1 gene product B0348.3 egl-8;pbo-2;B0348.4;B0348.3 Putative phosphatidylinositol phospholipase C B0348.5 B0348.5 Putative ortholog of C. elegans Y108G3B.A gene product B0348.6 ife-3;B0348.6 Translation initiation factor eIF4E, binds to mRNA cap structure translation initiation factor; ife-3 encodes one of five C. elegans homologs of the mRNA cap-binding protein eIF4E; by homology, IFE-3 is predicted to bind capped mRNA and mediate its recruitment to ribosomes during translation initiation; in vitro, IFE-3 binds a monomethylated guanosine cap structure but does not bind a trimethylated guanosine cap, which suggests that IFE-3 likely mediates translation of those mRNAs that do not contain a spliced-leader sequence; of the C. elegans eIF4E isoforms, IFE-3 is the most similar to human eIF4E and is the only isoform required for viability (homozygous ife-3 mutant embryos arrest in the early division stages of embryogenesis); IFE-3 is enriched in the adult gonad. B0350.1 B0350.1 Protein of unknown function, has weak similarity to uncharacterized C. elegans Y2C2A.1 B0350.2 unc-44;A013;B0350.2 Set of ankyrin-related proteins generated by alternate splicing, required for axonal guidance and proper axon fasciculation AO49 ankyrin; The unc-44 gene encodes an ankyrin-like protein required for proper sex myoblast and axonal guidance during development. B0350.3 B0350.3 Protein of unknown function B0353.1 B0353.1 Protein of unknown function B0361.10 B0361.8;B0361.10 Member of the glycosyl transferase group 1 protein family synaptobrevin B0361.2 B0361.2 Putative ortholog of C. elegans B0361.1 gene product B0361.3 B0361.3 Member of the sugar (and other) transporter family, has a region of weak similarity to solute carrier family 22 (organic cation transporter) member 2 (rat Slc22a2) B0361.4 B0361.4 Protein of unknown function B0361.5 B0361.5 Member of the phosphatidylserine decarboxylase family, which are involved in aminophospholipid biosynthesis, has low similarity to phosphatidylserine decarboxylase (S. cerevisiae Psd1p), which converts phosphatidyl-L-serine to phosphatidylethanolamine Phosphatidylserine decarboxylase B0361.6 B0361.6 Protein containing one uncharacterized ACR domain, has low similarity to uncharacterized human HSPC109 B0361.7 B0361.7 Member of the histidine acid phosphatase protein family, which hydrolyze phosphate esters at low pH, has low similarity to lysosomal acid phosphatase (rat Acp2), which is a tartrate-inhibitable lysosomal enzyme Acid phosphatase B0361.9 B0361.9 Protein containing a PAN domain, which may mediate protein-protein or protein-carbohydrate interactions B0365.1 B0365.1 Protein with high similarity to ATP citrate lyase (human ACLY), which catalyzes formation of acetyl-CoA and oxaloacetate in cholesterol and fatty acid synthesis, member of the ATP-citrate lyase or succinyl-CoA ligase family, contains a CoA binding domain ATP citrate lyase; This gene encodes a protein predicted by Eisenberg and coworkers, with 52% accuracy, to be mitochondrial. B0365.2 B0365.2 Member of the 7-transmembrane chemoreceptor family of G protein-coupled receptors (GPCR), has low similarity to C. elegans ODR-10, which is a G protein-coupled receptor involved in odorant response B0365.3 eat-6;spa-1;B0365.3 Sodium, potassium ATPase, alpha subunit; a P-type ATPase Na(+)/K(+) ATPase alpha subunit; eat-6 encodes an ortholog of the alpha subunit of a sodium/potassium ATPase, which in turn affects Na+,K(+)-ATPase activity of membranes by affecting the level of the phosphorylated intermediate of the Na+,K(+)-ATPase; EAT-6 affects relaxation of the pharyngeal muscles, fertility (and thus affects feeding); EAT-6 also affects body length, life span, and ASE, ASI and ASJ axonal outgrowth. B0365.5 B0365.5 Member of the C-type lectin family C-type lectin domain B0365.6 B0365.6 Member of the C-type lectin protein family C-type lectin domain B0365.7 B0365.7 Protein of unknown function, has weak similarity to uncharacterized dynein axonemal heavy chain 7 (human DNAH7) dynein B0379.1 B0379.1 Protein of unknown function B0379.2 B0379.2 Protein of unknown function, has very strong similarity to uncharacterized C. elegans Y106G6E.3 B0379.3 B0379.3 Protein of unknown function, has similarity over a small region of the C-terminus to S. cerevisiae Pan1p and to several uncharacterized C. elegans proteins mut-16 encodes a glutamine/asparagine (Q/N)-rich domain-containing protein that lacks obvious homologs outside of other nematode species; MUT-16 activity is required for RNA-mediated interference (RNAi), transgene silencing in germ-line and somatic tissues, and for maintaining low levels of transposon mobilization; MUT-16 is thus predicted to play a role in chromatin organizataion and/or regulation of gene expression. B0379.4 B0379.4 Member of the NLI interacting factor family, has high similarity to a region of S. cerevisiae Psr2p, which is a plasma membrane phosphatase required for sodium stress response B0379.5 B0379.5 Protein of unknown function B0379.6 B0379.6 Protein of unknown function B0379.7 B0379.7 Protein of unknown function, has high similarity to uncharacterized C. elegans B0205.10 B0391.1 B0391.1 Member of the 7-transmembrane chemoreceptor family of G protein-coupled receptors (GPCR), has high similarity to uncharacterized C. elegans Y102A5C.28 B0391.10 B0391.10 Protein with strong similarity to C. elegans Y73B3A.V gene product B0391.11 B0391.11 Protein of unknown function, putative paralog of C. elegans B0391.6 F-box protein B0391.3 B0391.3 Member of the 7-transmembrane chemoreceptor family of G protein-coupled receptors (GPCR), has high similarity to uncharacterized C. elegans F20E11.4 B0391.4 B0391.4 Member of the 7-transmembrane chemoreceptor family of G protein-coupled receptors (GPCR) B0391.5 B0391.5 Protein containing an F-box domain, which serve as a link between a target protein and a ubiquitin-conjugating enzyme, and a DUF38 domain of unknown function, has low similarity to C. elegans FOG-2, which is required for the sexual identity of germ cells F-box protein B0391.6 B0391.6 Protein containing four F-box domains, which serve as a link between a target protein and a ubiquitin-conjugating enzyme, and five DUF38 domains of unknown function, has a region of low similarity to C. elegans FOG-2 F-box protein; This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins; this gene's encoded protein also contains an FTH/DUF38 motif, which may also mediate protein-protein interaction. B0391.7 B0391.7 Protein of unknown function B0391.9 B0391.9 Protein containing a DUF38 domain of unknown function B0393.1 B0393.1 Member of the ribosomal protein S0 protein family 40S ribosomal protein; rps-0 encodes a small ribosomal subunit SA protein that appears to function as both a ribosomal component and a laminin receptor; by homology, RPS-0 is predicted to play roles in protein biosynthesis and cell adhesion; in C. elegans, RPS-0 activity is required for embryonic and germline development, vulval morphogenesis, and the overall health of the animal. B0393.2 B0393.2 Protein containing a TBC domain, which may be GTPase activators of Rab-like small GTPases, has low similarity to uncharacterized human KIAA0210 Probable rabGAP domains B0393.3 B0393.3 Contains an F-box domain, which serve as a link between a target protein and a ubiquitin-conjugating enzyme Leucine Rich Repeat (2 copies) (2 domains) B0393.4 B0393.4 Protein of unknown function B0393.5 B0393.5 Protein containing five epidermal growth factor (EGF)-like domains, has weak similarity to a region of fibrillin-1 (human FBN1), which is an extracellular matrix protein associated with Marfan Syndrome, Shprintzen-Goldberg syndrome, and ectopia lentis EGF-like aspartic acid and asparagine hydroxylation sites B0393.6 B0393.6 Protein with weak similarity to C. elegans T20F5.6 gene product Zinc finger, C3HC4 type (RING finger) B0393.7 B0393.7 Protein containing three low-density lipoprotein receptor class A domains, has a region of low similarity to a region of low density lipoprotein receptor-related protein 2 (glycoprotein 330, human LRP2) LDL receptor ligand-binding repeat bearing protein B0393.8 B0393.8 Protein of unknown function, putative paralog of C. elegans F22D6.14 B0395.1 B0395.1 Member of the sodium or hydrogen exchanger family, which control pH in actively metabolizing cells, has moderate similarity to a region of sodium-hydrogen exchanger 1 (rat Slc9a1), which is an antiporter involved in pH, cell volume, and cell shape control Sodium/Proton antiporter; nhx-1 encodes a sodium/proton exchanger expressed intracellularly within hypodermal and muscle cells; NHX-1 is required for embryonic viability, and is thought to prevent intracellular acidification by catalysing the electroneutral exchange of vesicular sodium for an intracellular proton. B0395.2 B0395.2;ACAT Member of the sterol O-acyltransferase family, which are involved in cholesterol esterification, has moderate similarity to acyl-Coenzyme A:cholesterol acyltransferase (mouse Soat1), which acts in lipoprotein metabolism and cholesterol homeostasis Sterol O-acyltransferase B0395.3 B0395.3 Member of the choline or carnitine O-acyltransferase family, has low similarity to choline acetyltransferase (human CHAT), which synthesizes acetylcholine in neurons and shows decreased activity in Alzheimer's Disease choline O-acetyltransferase; B0395.3 is orthologous to the human gene CHOLINE ACETYLTRANSFERASE ISOFORM R (CHAT; OMIM:118490), which when mutated leads to disease. B0399.A B0399.1;B0399.A Protein containing a calmodulin binding domain, has a region of moderate similarity to Ca2+-activated small-intermediate conductance K+ channel 3 (rat Kcnn3), which is a voltage-independent, apamin-sensitive K+ channel B0403.1 B0403.1 Protein of unknown function, has a region of strong similarity to a region of C. elegans ASP-2, which is an aspartyl protease B0403.2 B0403.2 Member of the ubiquitin-conjugating enzyme (E2) family, which catalyze the covalent attachment of ubiquitin to target proteins, has a region of low similarity to a region of baculoviral IAP repeat-containing 6 (human BIRC6) ubiquitin-conjugating enzyme B0403.3 B0403.3 Putative ortholog of C. elegans B0404.3 gene product B0403.4 B0403.4 Protein with high similarity to protein disulfide isomerase-related protein (rat Rn.2685), which catalyzes disulfide isomerization and the formation of disulfide bonds during protein folding, member of the thioredoxin family protein disulfide-isomerase; This gene encodes a protein predicted by Eisenberg and coworkers, with 52% accuracy, to be mitochondrial. B0410.1 B0410.1 Protein of unknown function B0410.2 B0410.2 Protein of unknown function, has low similarity to uncharacterized mouse Ltap B0410.3 B0410.3 Protein of unknown function B0412.1 B0412.1 Member of the SKI, SNO or DAC family, which are involved in proliferation or development, has a region of moderate similarity to a region of dachshund 1 (Drosophila) homolog (mouse Dach1), which may play a role in neurogenesis and cell-fate determination yeast NUD1 protein B0412.2 daf-7;B0412.2 Ligand that negatively regulates dauer larva development by transduction of chemosensory signals from amphidial neurons ASI, ADF and ASG, member of the TGF-beta superfamily transforming growth factor beta proteins; daf-7 encodes a member of the transforming growth factor beta superfamily that affects dauer larvae formation in a TGF-beta-mediated pathway and also affects egg laying; expressed in the ASI neurons. B0412.3 B0412.3 Protein of unknown function B0412.4 B0412.4 Member of the ribosomal protein S29 protein family 40S ribosomal protein S29; rps-29 encodes a small ribosomal subunit S29 protein; by homology, RPS-29 is predicted to function in protein biosynthesis; in C. elegans, RPS-29 activity is broadly required for embryonic and germline development, normal body coloration and morphology, normal postembryonic growth rates, and the overall health of the animal. B0412.5 B0412.5 Protein of unknown function B0414.1 B0414.1 Protein containing a DUF216 domain of unknown function, has low similarity to uncharacterized C. elegans C08F11.9 7TM chemoreceptor, srz family B0414.2 rnt-1;run;B0414.2 Putative member of PEBP2/CBF family of DNA binding transcription factors rnt-1 is homologous to RUNT and LOZENGE in Drosophila melanogaster, and to human RUNX1 (AML1, OMIM:151385, mutated in familial platelet disorder and acute myeloid leukemia), RUNX2 (OMIM:600211, mutated in cleidocranial dysplasia), and RUNX3 (OMIM:600210). B0414.3 B0414.3 Protein with high similarity to histone H1 (C. elegans H1.4), which is involved in gametogenesis, member of the histone H1 and H5 family of linker histones histone H1 B0414.4 B0414.4 Protein containing a leucine rich repeat C-terminal cysteine rich domain B0414.5 cpb-3;B0414.5 Protein of unknown function, has a region of moderate similarity to a region of cytoplasmic polyadenylation element binding protein (mouse Cpeb), which is a sequence-specific RNA binding protein that regulates cytoplasmic polyadenylation RNA binding protein; The cbp-3 gene encodes a cytoplasmic polyadenylation element binding (CPEB) protein homolog. B0414.6 glh-3;B0414.6 RNA helicase in the germ line and a component of P granules; putative ortholog of S. cerevisiae DBP1 gene product, an ATP-dependent RNA helicase of the DEAD box family RNA helicase; glh-3 encodes a predicted DEAD-like RNA helicase; GLH-3 interacts with itself and with CSN-5, KGB-1, ZYX-1, and GLH-1 in vitro, and is expressed in association with P granules throughout development. B0414.7 B0414.7 Serine/threonine protein kinase of the MAP kinase kinase (MEK kinase) subfamily, has similarity to S. cerevisiae Ssk2p and Ssk22p protein kinase B0414.8 B0414.8 Protein of unknown function B0416.1 B0416.1 Protein of unknown function, has moderate similarity to uncharacterized C. elegans T13G4.3 B0416.2 B0416.2 Protein of unknown function, has high similarity to uncharacterized C. elegans ZK856.6 B0416.3 B0416.3 Protein of unknown function B0416.4 B0416.4 Protein containing a C3HC4 type RING zinc finger, which may mediate protein-protein interactions, has low similarity to uncharacterized C. elegans F53F8.3 B0416.5 B0416.5 Member of an uncharacterized protein family B0416.6 gly-13;B0416.6 N-acetylglucosaminyltransferase I alpha-1,3-mannosyl-glycoprotein beta-1,2-n-acetyglucosaminyltransferase B0416.7 B0416.7 Protein of unknown function, has weak similarity to C. elegans K04F1.8 B0432.1 B0432.1 Protein of unknown function B0432.10 B0432.10 Protein of unknown function B0432.11 B0432.11 Protein of unknown function, has high similarity to uncharacterized C. elegans K07H8.7 B0432.12 B0432.12 Member of the C-type lectin family, has weak similarity to human receptor for C1q/MBL/SPA C-type lectins B0432.13 B0432.13 Protein with weak similarity to C. elegans H10E21.5 gene product B0432.2 B0432.2 Protein with high similarity to RNA-binding protein regulatory subunit (rat Dj1),which may regulate RNA-protein interactions and play a role in fertilization, member of the ThiJ-PfpI family B0432.3 B0432.3 Protein of unknown function B0432.4 B0432.4 Member of the mitochondrial carrier protein family of membrane transporters, has moderate similarity to dicarboxylate carrier protein (C. elegans K11G12.5) mitochrondrial 2-oxoglutarate/malate carrier protein B0432.5 cat-2;B0432.5 Putative tyrosine hydroxylase aromatic amino acid hydroxlase; cat-2 encodes a putative tyrosine hydroxylase that affects dopamine levels that in turn affect locomotory slowing in response to food; expressed in dopamanergic as well as other neurons, male spicules, and male ray neurons. B0432.6 B0432.6 Putative coiled-coil protein, has weak similarity to human myosin heavy chains B0432.7 B0432.7 Protein of unknown function B0432.8 B0432.8 Member of the TatD-related DNase family This gene encodes a protein predicted by Eisenberg and coworkers, with 52% accuracy, to be mitochondrial. B0432.9 B0432.9 Protein containing a C3HC4 type RING zinc finger, which may mediate protein-protein interactions zinc finger protein B0454.1 B0454.1 Protein of unknown function, has moderate similarity to uncharacterized C. elegans B0454.9 B0454.10 B0454.10 Putative ortholog of C. elegans B0454.2 gene product 7TM chemoreceptor, sri family B0454.2 B0454.2 Member of the 7-transmembrane chemoreceptor family of G protein-coupled receptors (GPCR), has high similarity to uncharacterized C. elegans B0454.10 7TM chemoreceptor, sri family B0454.3 B0454.3 Member of the 7-transmembrane chemoreceptor family of G protein-coupled receptors (GPCR), has high similarity to uncharacterized C. elegans B0454.4 7TM chemoreceptor, sri family B0454.4 B0454.4 Member of the 7-transmembrane chemoreceptor family of G protein-coupled receptors (GPCR), has high similarity to uncharacterized C. elegans B0454.10 7TM chemoreceptor, sri family B0454.5 B0454.5 Protein of unknown function B0454.6 B0454.6 Member of the amino acid permease family of membrane transporters, has moderate similarity to solute carrier family 7 member 4 (human SLC7A4), which mediates the uptake of cationic amino acids such as arginine amino acid permease B0454.7 B0454.7 Member of the C-type lectin protein family B0454.8 B0454.8 Protein containing five DUF225 domains of unknown function, has high similarity to uncharacterized C. elegans B0554.2 B0454.9 B0454.9 Protein of unknown function, has moderate similarity to uncharacterized C. elegans B0454.1 B0457.1 B0457.1 Protein with similarity to a human leukocyte transmembrane protein, CD97beta G-protein coupled receptor protein; lat-1 encodes a predicted latrophilin that affects embryonic elongation, pharyngeal development, and reproductive organ formation; apically localized in developing epithelia and localized to presynaptic surfaces in neurons. B0457.2 B0457.2 Protein with moderate similarity to C. elegans C38C6.3 gene product elastin precusor B0457.3 B0457.3 Protein of unknown function, has high similarity to uncharacterized C. elegans B0457.4 B0457.4 B0457.4 Protein of unknown function, has high similarity to uncharacterized C. elegans B0457.3 B0462.1 B0462.1 Protein of unknown function, has weak similarity to uncharacterized C. elegans Y102A5C.4 B0462.2 B0462.2 Member of the 7-transmembrane chemoreceptor family of G protein-coupled receptors (GPCR) B0462.3 B0462.3 Protein of unknown function, has low similarity to uncharacterized C. elegans F55C9.1 B0464.1 B0464.1 Protein with high similarity to aspartyl-tRNA synthetase (human DARS), which associates with a multisynthetase complex, contains an OB-fold nucleic acid binding domain and a class II asparagine, aspartic acid and lysine tRNA synthetase (D, K and N) domain Aspartyl-tRNA synthetase B0464.2 B0464.2 Protein containing eight TPR (tetratrico peptide repeat) domains, which may mediate protein-protein interactions, has moderate similarity to TPR-containing SH2-binding phosphoprotein (mouse Tsbp) TPR Domain B0464.3 B0464.3 Protein of unknown function, has weak similarity to C. elegans C24A3.2 B0464.4 B0464.4 Putative ortholog of D. melanogaster EGH (egghead) protein zw4; bre-3 encodes a protein similar to beta-glycosyltransferases from bacteria that is required for the toxicity of Bacillus thuringiensis Cry5B; BRE-3 may act in a pathway with bre-5 and is expressed and functions in the gut epithelium. B0464.5 spk-1;rsk-1;CeSRPK;B0464.5 Serine/threonine kinase; phosphorylates the RS domain of putative splicing factor SF2 Eukaryotic protein kinase domain; spk-1 encodes a serine/threonine kinase orthologous to the highly conserved serine/arginine-rich protein kinases (SRPKs) that phosphorylate SR proteins, essential components of the pre-mRNA splicing machinery; SPK-1, required for embryogenesis and germline development, can directly bind and phosphorylate RSP-3 (CeSF2/ASF), an SR splicing factor homolog; SPK-1 is expressed predominantly in the adult germline; SPK-1 is homologous to human RSK2, which when mutated leads to Coffin-Lowry syndrome (OMIM:303600). B0464.6 B0464.6 Protein of unknown function B0464.7 pme-1;3J557;B0464.7 Protein with high similarity to breakpoint cluster region protein 1 (barrier autointegration factor, human BCRP1), which is a host cell protein with DNA binding activity, member of the barrier to autointegration factor family barrier-to-autointegration factor; baf-1 encodes a small, novel protein that is highly conserved amongst metazoa; BAF-1 binds double-stranded DNA nonspecifically in vitro and is essential for proper chromosome segregation, embryogenesis, and gonad development in vivo; biochemical and phenotypic analyses suggest that BAF-1 functions as an intramolecular bridge that mediates nuclear assembly and chromatin capture by the reforming nuclear envelope; by homology with mammalian BAF proteins, BAF-1 is also predicted to play a role in regulating gene expression and higher-order chromatin structure; during interphase, BAF-1 colocalizes with LMN-1/lamin to the nuclear envelope and nuclear interior; during mitosis, BAF-1 is present in a more punctate pattern, localizing near condensing chromatin and maintaining this localization through telophase; BAF-1 localization during nuclear assembly requires the activity of LMN-1/lamin, EMR-1/emerin, and LEM-2/MAN1. B0464.8 B0464.8 Protein of unknown function B0464.9 B0464.9 Protein of unknown function B0478.1 jnk-1;B0478.1 Neuronally expressed serine/threonine protein kinase of the MAP kinase subfamily MAP kinase B0478.2 B0478.2 Member of the reverse transcriptase protein family, which are RNA-dependent DNA polymerases, has high similarity to uncharacterized C. elegans H02F09.4 B0478.3 B0478.3 Protein with moderate similarity to C. elegans Y52B11A.8 gene product B0491.1 B0491.1 Protein with moderate similarity to mannosyltransferase I (glycosylphosphatidylinositol mannosyltransferase I, rat Pigm), which transfers the first mannose to glycosylphosphatidylinositol in the endoplasmic reticulum biosynthesis of GPI membrane anchors B0491.2 sqt-1;rol-5;B0491.2 Collagen; member of the Collagen Triple Helix Repeat (20 Copies) protein family cuticle collagen SQT-1 B0491.3 B0491.3 Protein with moderate similarity to C. elegans T05G5.7, which is involved in embryogenesis and morphogenesis B0491.4 B0491.4 Protein containing a neurotransmitter-gated ion-channel ligand binding domain, has low similarity to uncharacterized C. elegans Y74E4A.1 B0491.5 B0491.5 Protein of unknown function B0491.6 B0491.6 Protein of unknown function B0491.7 B0491.7 Protein with high similarity to diphthamide methyltransferase (S. cerevisiae Dph5p), which is required for diphthamide biosynthesis, member of the tetrapyrrole (corrin or porphyrin) methylases family, which use S-AdoMet in substrate methylation diphthine synthase; B0491.7 encodes a putative diphthine synthase orthologous to S. cerevisiae DPH5; DPH5 is an S-adenosylmethionine:EF-2 methyltransferase required for the enzymatic conversion of 3-amino-3-carboxypropyl-histidine to diphthine; DPH5 adds at least the last two of the three methyl groups present in diphthine, and is homologous to bacterial AdoMet:uroporphyrinogen III methyltransferases. B0495.1 sre-1;B0495.1 G protein-coupled receptor, expressed in chemosensory neurons, no homolog found in human or D. melanogaster 7TM chemoreceptor, sre family B0495.10 B0495.10 Protein of unknown function, has a region of low similarity to copine 6 (mouse Cpne6), which is a calcium-dependent phospholipid binding protein that may play roles in Ca2+ sensing and neuronal plasticity B0495.2 B0495.2 Serine/threonine protein kinase of the cyclin-dependent kinase subfamily, has strong similarity to human and D. melanogaster CDC2-like protein kinases (PITSLRE proteins) CDC2 B0495.4 B0495.4 Member of the sodium or hydrogen exchanger family, which control pH in actively metabolizing cells, has moderate similarity to a region of sodium-hydrogen exchanger type 3 (human SLC9A3), which plays roles in sodium absorption and bicarbonate transport NA(+)/H(+) exchanger; nhx-2 encodes a sodium/proton exchanger expressed in the apical membranes of intestinal cells; NHX-2 is required for normally high growth rates, and for propagation or maintenance of the germline, NHX-2 is thought to prevent intracellular acidification by catalysing the electroneutral exchange of extracellular sodium for an intracellular proton. B0495.5 B0495.5 Protein of unknown function B0495.6 B0495.6 Protein of unknown function B0495.7 B0495.7 Protein of unknown function, has low similarity to uncharacterized C. elegans C44B7.11 B0495.8 B0495.8 Member of an uncharacterized protein family B0495.9 B0495.9 Protein of unknown function B0496.1 B0496.1 Protein containing a BTB (BR-C, ttk and babor) or POZ (Pox virus and zinc finger) domain, which are found in some DNA and actin binding proteins and may mediate protein-protein interactions, has high similarity to uncharacterized C. elegans B0496.2 B0496.2 B0496.2 Protein containing a BTB (BR-C, ttk and babor) or POZ (Pox virus and zinc finger) domain, which are found in some DNA and actin binding proteins and may mediate protein-protein interactions, has high similarity to uncharacterized C. elegans R13A1.3 B0496.3 B0496.3 Protein containing two protein kinase domains, has a region of low similarity to rat LOC60328, which is a microtubule/MAP-affinity regulating kinase that participates in microtubule stability and control of cell polarity ser/thr protein kinase B0496.4 B0496.4 Protein of unknown function B0496.5 B0496.5 Protein of unknown function B0496.6 B0496.6 Protein with strong similarity to C. elegans C36H8.1 gene product B0496.7 B0496.7 Protein with high similarity to cysteine-rich intestinal protein (human CRIP1), which binds zinc and may function as a zinc carrier protein, contains LIM domains, which may mediate protein-protein interactions B0496.8 B0496.8 Protein containing three LIM domains, which may mediate protein-protein interactions, has a region of low similarity to a region of four and a half LIM domains 1 (human FHL1) LIM-domain protein B0507.1 B0507.1 Protein with moderate similarity to C. elegans M03F4.6 gene product B0507.10 B0507.10 Protein with strong similarity to C. elegans B0507.7 gene product B0507.2 B0507.2 Protein of unknown function, has weak similarity to S. cerevisiae Yor275p B0507.3 B0507.3 Protein of unknown function B0507.4 B0507.4 Protein with strong similarity to C. elegans ZC196.3 gene product B0507.5 B0507.5 Protein of unknown function B0507.6 B0507.6 Protein of unknown function, has weak similarity to uncharacterized C. elegans F53H2.1 B0507.7 B0507.7 Protein of unknown function, has low similarity to uncharacterized C. elegans B0507.10 B0507.8 B0507.8 Protein of unknown function, has low similarity to uncharacterized C. elegans B0507.9 B0507.9 B0507.9 Protein of unknown function, has low similarity to uncharacterized C. elegans B0507.8 B0511.1 B0511.1 Member of the FKBP-type peptidyl-prolyl cis-trans isomerase family, has weak similarity to a region of FK506 binding protein 10 65 kDa (mouse Fkbp10), which is an immunophilin that interacts with serine/threonine kinase Raf1 and with tropoelastin fkb-7 encodes a peptidylprolyl cis/trans isomerase homologous to mammalian FK506-binding proteins; by homology, FKB-7 could function in a number of different processes including protein folding, signal transduction, and regulation of muscle contraction; however, as loss of fkb-7 function via RNA-mediated interference (RNAi) does not result in any obvious abnormalities, the precise role of FKB-7 in C. elegans development and/or behavior is not yet known. B0511.10 B0511.10 Protein with high similarity to eukaryotic translation initiation factor 3 subunit 6 (human EIF3S6), contains a PCI (proteasome, COP9-complex and eIF3) or PINT (Proteasome, Int-6, Nip-1 and TRIP-15) domain eif-3. B0511.11 B0511.11 Protein of unknown function, has strong similarity to C. elegans K05F6.10 over 61 amino acids of the C-terminus B0511.12 B0511.12 Protein of unknown function, has moderate similarity to uncharacterized mouse Pcnx B0511.13 B0511.13 Protein of unknown function B0511.14 B0511.14 Protein of unknown function B0511.2 B0511.2 Protein with strong similarity to C. elegans Y23H5A.7 gene product B0511.3 B0511.3 Protein containing an F-box domain, which serve as a link between a target protein and a ubiquitin-conjugating enzyme, and a DUF38 domain of unknown function, has low similarity to C. elegans FOG-2, which is required for the sexual identity of germ cells This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins; this gene's encoded protein also contains an FTH/DUF38 motif, which may also mediate protein-protein interaction. B0511.4 B0511.4 Protein containing a protein kinase domain, has low similarity to camKI-like protein kinase (human LOC57118), which is a granulocyte-specific protein kinase that activates ERK/MAP kinase activity protein kinase B0511.5 B0511.5 Protein of unknown function, has low similarity to a region of cuticulin component (C. elegans CUT-1) B0511.6 B0511.6 Member of the DEAD or DEAH box ATP-dependent RNA helicase family, contains a helicase conserved C-terminal domain, has low similarity to S. cerevisiae Rrp3p, which is a helicase required for maturation of pre-rRNA helicase B0511.7 B0511.7 Protein containing a forkhead associated (FHA) domain, which bind phosphopeptides, has moderate similarity to protein phosphatase-1 regulatory 8 (human PPP1R8), which is a site-specific magnesium-dependent endoribonuclease B0511.8 B0511.8 Protein with weak similarity to S. cerevisiae Cdc1p, a protein involved in ion homeostasis, intrachromosomal recombination, and nuclear division B0511.9 B0511.9 Protein of unknown function B0513.1 B0513.1 Protein of unknown function, has low similarity to uncharacterized C. elegans C04B4.4 gei-5 encodes a novel protein that was identified in screens for molecules that interact with GEX-3, a homolog of mammalian protein ligands of the small GTPase Rac1, that is essential for ventral enclosure during embryonic development; as loss of gei-5 function via RNA-mediated interference (RNAi) does not result in any abnormalities, the precise role of GEI-5 in C. elegans development and/or behavior is not yet known; GEI-5 is expressed in body wall and vulval muscles, and is also detected in the intestine, neurons, and probably the hypodermis. B0513.2 B0513.2 Protein of unknown function B0513.3 B0513.3 Protein with high similarity to 60S ribosomal protein L29 (S. pombe Rpl29p), which binds RNA, member of the ribosomal L29e family, which are part of the large ribosomal subunit 60S ribosomal protein L29; rpl-29 encodes a large ribosomal subunit L29 protein; by homology, RPL-29 is predicted to function in protein biosynthesis; in C. elegans, loss of rpl-29 function via RNA-mediated interference (RNAi) does not result in any obvious abnormalities. B0513.4 B0513.4 Protein of unknown function B0513.5 B0513.5 Protein with high similarity to proline oxidase (proline dehydrogenase, human PRODH), which catalyzes conversion of proline to glutamate and is associated with type-I hyperprolinemia and behavioral disorders, member of the proline dehydrogenase family B0513.6 B0513.6 Protein of unknown function, has very strong similarity to uncharacterized C. elegans Y45F10C.1 B0513.7 B0513.7 Member of the transposase family, which are required for excising and inserting mobile genetic elements, has high similarity to uncharacterized C. elegans Y54G11A.8 B0513.9 B0513.9 Member of the synaptobrevin family, which are intrinsic membrane proteins found in small synaptic vesicles B0523.1 Cehd-9;B0523.1 Putative tyrosine protein kinase, has similarity to human and D. melanogaster FER (fps/fes-related) protein kinases Tyrosine kinase; kin-31 encodes a predicted tyrosine protein kinase expressed in the nucleus and cytoplasm of body-wall muscle cells; the expression of kin-31 was experimentally verified by RT-PCR. B0523.3 B0523.3 Putative ortholog of C. elegans B0523.4 gene product B0523.5 Ce-FLI-1;B0523.5 Protein with high similarity to flightless I homolog (human FLII), which is an actin binding protein, contains twelve leucine rich repeats, member of the gelsolin family, which act as actin-modulating proteins that end-block or cap actin filaments fli-1 encodes a homolog of Drosophila flightless-I; can interact with human Ha-Ras and human actin in vitro; mRNA levels are highest in embryos. B0524.2 B0524.E;B0524.2 Protein of unknown function, has moderate similarity to uncharacterized C. elegans D1054.1 B0524.3 B0524.D;B0524.3 Protein with moderate similarity to C. elegans B0524.4 gene product B0524.5 B0524.5 Protein of unknown function, contains similarity to mouse transcription regulator (GB:L35307) B0524.6 B0524.A;B0524.6 Protein of unknown function B0524.B B0524.4;B0524.B Protein containing a WSN domain of unknown function, has low similarity to uncharacterized C. elegans R06B10.2 B0524.F B0524.1;B0524.F Protein of unknown function B0545.1 B0545.1 Putative ortholog of C. elegans tpa-1 gene product protein kinase C B0545.3 B0545.3 Member of the SCP-like extracellular protein family, has moderate similarity to uncharacterized C. elegans F49E11.5 extracellular protein B0545.4 B0545.4 Protein with strong similarity to C. elegans K09A11.1 gene product transposase B0546.1 B0546.1 Protein of unknown function, has weak similarity to C. elegans mai-1 ATPase inhibitor B0546.2 B0546.2 Member of the ovarian tumor (OTU)-like cysteine protease family B0546.3 B0546.3 Protein of unknown function B0546.4 B0546.4 Protein with moderate similarity to C. elegans F37A8.5 gene product B0546.5 B0546.5 Protein of unknown function, has strong similarity to uncharacterized C. elegans F16D3.6 B0547.1 B0547.1 Protein with high similarity to constitutive photomorphogenic subunit 5 (human COPS5), which is a subunit of the signalosome complex that phosphorylates regulators involved in signal transduction, member of the Mov34, MPN or PAD-1 family csn-5 encodes an ortholog of subunit 5 of the COP9 signalosome complex (CSN5), which in turn is a pan-eukaryotic multiprotein complex that positively regulates E3 ubiquitin ligases, physically interacts with SCF-type E3 ubiquitin ligases, and probably regulates protein degradation; CSN-5 (along with KGB-1 and ZYX-1) physically binds germline RNA helicases (GLH proteins), and csn-5(RNAi) results in sterile worms with small gonads and no oocytes, causing oogenesis to cease, but not affecting the initial assembly of P granules -- a defect essentially identical to that produced by RNAi with a combination of glh-1 and glh-4. B0547.2 B0547.2 Protein of unknown function B0547.4 B0547.4 Protein of unknown function, has high similarity to uncharacterized C. elegans C06G8.4 7TM chemoreceptor, srd family B0554.1 B0554.1 Protein of unknown function B0554.2 B0554.2 Protein containing five DUF225 domains of unknown function, has high similarity to uncharacterized C. elegans B0554.4 B0554.3 B0554.3 Protein of unknown function B0554.4 B0554.4 Protein containing one DUF225 domain of unknown function, has high similarity to uncharacterized C. elegans B0554.2 B0554.5 B0554.5 Protein of unknown function, has strong similarity to uncharacterized C. elegans Y39D8A.1 B0554.6 B0554.6 Protein of unknown function, has high similarity to uncharacterized C. elegans ZK6.11 B0554.7 B0554.7 Protein of unknown function, has high similarity to uncharacterized C. elegans Y39D8A.1 B0563.1 B0563.1 Protein of unknown function B0563.2 B0563.2 Member of the tetraspanin family, which contain an N-terminal transmembrane domain that is a signal sequence and membrane anchor, has low similarity to CD53 antigen (human CD53), which is a pan-leukocyte cell surface antigen transpanin B0563.3 B0563.3 Protein containing one uncharacterized domain UPF0005 B0563.4 B0563.4 Protein of unknown function B0563.5 B0563.5 Protein of unknown function B0563.6 B0563.6 Member of the rhodopsin family of G protein-coupled receptors (GPCR), has weak similarity to somatostatin receptor 5 (rat Sstr5), which inhibits adenylyl cyclase activity and mediates inhibitory effects of somatostatin on cell proliferation and secretion B0563.7 B0563.7 Protein containing four EF hand domains, which are found in signaling, buffering or transport proteins, has weak similarity to myosin regulatory light chain (human MLCB), which is involved in RHO protein and G protein-coupled receptor signal transduction Calmodulin B0563.8 B0563.8 Protein of unknown function B0564.1 B0564.1 Member of the RNase PH family of 3' exoribonucleases, which are involved in RNA processing, has low similarity to S. cerevisiae Ski6p, which is a component of the exosome 3'-5' exoribonuclease complex involved in 3' processing and degradation of RNA B0564.10 unc-30;B0564.10 Homeodomain transcription factor specifically expressed in GABAergic neurons, is required for axonal pathfinding; has similarity over 293 amino acids to human PITX2 paired-like homeodomain transcription factor homeobox protein (otd subfamily); unc-30 encodes a paired-like homeodomain transcription factor orthologous to vertebrate Pitx homeodomain proteins, such as mouse Pitx2; UNC-30 controls the terminal differentiation of all 19 type D GABA-ergic motor neurons by directly regulating the expression of UNC-25/GAD and UNC-47/VGAT, which are responsible for GABA formation and secretion, respectively; UNC-30 is expressed most strongly in type D motor neurons during early L1 and L2 larval stages. B0564.2 B0564.2 Protein of unknown function B0564.3 B0564.3 Member of the C. elegans putative membrane protein family 8, has low similarity to a region of bestrophin (human VMD2), which plays a role in vision and is associated with Bests disease, adult vitelliform macular dystrophy, and bull's eye maculopathy Putative membrane protein B0564.4 B0564.4 Member of the C. elegans putative membrane protein family 8, has moderate similarity to a region of bestrophin (human VMD2), which plays a role in vision and is associated with Bests disease, adult vitelliform macular dystrophy, and bull's eye maculopathy Putative membrane protein B0564.5 B0564.5 Member of the transposase family, which are required for excising and inserting mobile genetic elements, has very strong similarity to uncharacterized C. elegans F44F4.8 transposase B0564.6 B0564.6 Protein containing leucine rich repeats, which mediate protein-protein interactions, has very strong similarity to uncharacterized C. elegans B0564.9 Leucine Rich Repeat (2 copies) (2 domains) B0564.7 B0564.7 Protein containing a C3HC4 type RING zinc finger, which may mediate protein-protein interactions Zinc finger, C3HC4 type (RING finger) B0564.9 B0564.9 Protein containing leucine rich repeats, which mediate protein-protein interactions, has very strong similarity to uncharacterized C. elegans B0564.6 Leucine Rich Repeat (2 copies) (2 domains) BC1 bc1 Putative ortholog of C. elegans Y73E7A.6 gene product BE0003N10.1 BE0003N10.1 Protein with weak similarity to C. elegans B0564.1 gene product BE0003N10.2 BE0003N10.2 Protein of unknown function BE0003N10.3 BE0003N10.3 Putative ortholog of C. elegans F46E10.A gene product BE10.1 BE10.1 Protein of unknown function, has low similarity to uncharacterized C. elegans T28C6.5 BE10.2 BE10.2 Protein of unknown function BE10.3 BE10.3 Protein of unknown function, has a region of low similarity to C. elegans PHA-1, which is involved in pharyngeal development BE10.4 BE10.4 Protein of unknown function BRE-5 bre-5 Putative beta-1,3-galactosyltransferase, mutations in which lead to resistance to several B. thuringiensis toxins C01A2.1 C01A2.1 Protein with moderate similarity to C. elegans ZK402.1 gene product C01A2.2 C01A2.2 Protein of unknown function C01A2.3 C01A2.3 Member of the 60Kd inner membrane protein family, has low similarity to S. cerevisiae Oxa1p, which is required for assembly of F1F0-ATP synthase and cytochrome oxidase and for export of Cox2p termini through the inner mitochondrial membrane cytochrome oxidase biogenesis protein like C01A2.4 C01A2.4 Protein of unknown function, has low similarity to uncharacterized human BC-2 C01A2.5 C01A2.5 Protein of unknown function, has moderate similarity to uncharacterized human C20orf43 S.pombe hypothetical protein C1D4.09C like C01A2.6 C01A2.6 Protein of unknown function C01A2.7 C01A2.7 Protein of unknown function C01B10.1 C01B10.1 Member of the DEAD or DEAH box ATP-dependent RNA helicase family and contains a helicase conserved C-terminal domain, has high similarity to uncharacterized C. elegans F15B10.2 C01B10.10 C01B10.10 Member of the carboxylesterase type B family, has low similarity to esterase 2 (rat Es2), which catalyzes hydrolysis of a variety of carboxylic esters including the anti-cholesteraemic agent clofibrate and may have a role in lipid metabolism C01B10.3 C01B10.3 Protein of unknown function, has a region of weak similarity to inositol polyphosphate-5-phosphatase II (5 phosphatase II, human INPP5A), which hydrolyzes various signaling molecules including inositol 1,4,5 trisphosphate C01B10.4 C01B10.4 Member of the carboxylesterase type B family, has low similarity to C. elegans GES-1, which is a carboxylesterase expressed in gut cells C01B10.5 H1.Q;C01B10.5 Histone H1 hil-7 encodes a histone H1.1 isoform that is required in the germline for chromatin silencing (assayed by silencing of transgenic DNA), for proliferation and differentiation, and for fertility; hil-7(RNAi) phenotypes resemble the Mes phenotype resulting from the desilencing of genes required for somatic differentiation in the germline; HIL-7 is required in both the hermaphrodite and the male germlines, and is ubiquitously expressed in all nuclei (somatic and germline). C01B10.6 C01B10.6 Protein of unknown function C01B10.7 C01B10.7 Protein with moderate similarity to C. elegans K02E11.6 gene product C01B10.8 C01B10.8 Member of the spermine and spermidine synthesis family, which are involved in spermidine biosynthesis, has low similarity to uncharacterized human CGI-01 C01B10.9 C01B10.9 Protein containing a type I phosphodiesterase or nucleotide pyrophosphatase domain, has weak similarity to a region of ectonucleotide phosphodiesterase 3 (rat LOC54410), which releases nucleoside 5' monophosphates C01B12.1 C01B12.1 Protein with high similarity to C. elegans ROL-8, which is structurally similar to vertebrate type IX collagens, contains two collagen triple helix repeats, which are found in some extracellular proteins, and a nematode cuticle collagen N-terminal domain cuticular collagen; Uncloned locus that affects alae formation and body morphology such that mutants exhibit a slightly dumpy phenotype and the bodies of mutants are helically twisted. C01B12.2 C01B12.2 Protein containing a SAND (Sp100,AIRE-1, NucP41/75 and DEAF-1/suppressin) domain, which may bind DNA, has a region of low similarity to a region of glucocorticoid modulatory element binding protein 1 (human GMEB1) C01B12.3 C01B12.3 Member of the C. elegans putative membrane protein family 8, has a region of moderate similarity to a region of bestrophin (human VMD2), which plays a role in vision and causes Bests disease, adult vitelliform macular dystrophy, and bull's eye maculopathy C01B12.3 is orthologous to the human gene VITELLIFORM MACULAR DYSTROPHY PROTEIN (VMD2; OMIM:153700), which when mutated leads to disease. C01B12.4 C01B12.4 Protein of unknown function, has low similarity to uncharacterized C. elegans W01D2.5 C01B12.5 C01B12.5 Member of the C. elegans putative membrane protein family 8, has a region of moderate similarity to a region of bestrophin (human VMD2), which plays a role in vision and causes Bests disease, adult vitelliform macular dystrophy, and bull's eye maculopathy C01B12.6 C01B12.6 Member of the Tc3 Transposase protein family transposase C01B12.7 C01B12.7 Protein of unknown function C01B12.8 C01B12.8 Protein of unknown function C01B4.2 C01B4.2 Protein with strong similarity to C. elegans Y19D10A.3 gene product C01B4.3 C01B4.3 Protein of unknown function, has similarity to C. elegans olfactory receptor ODR-10 7TM chemoreceptor, str family C01B4.5 C01B4.5 Protein of unknown function, has similarity to C. elegans SRD-1 7TM chemoreceptor, srd family C01B4.7 C01B4.7 Protein with similarity to human and D. melanogaster sodium-dependent inorganic phosphate cotransporters C01B4.B C01B4.10;C01B4.B Member of the 7-transmembrane chemoreceptor family of G protein-coupled receptors (GPCR), has weak similarity to C. elegans ODR-10, which is a G protein-coupled receptor involved in odorant response C01B4.E C01B4.9;C01B4.E Protein with weak similarity to solute carrier family 16 member 7 (monocarboxylate cotransporter 2, rat Slc16a7), which mediates the transport of lactate and pyruvate across plasma membranes C01B4.G C01B4.8;C01B4.G Member of the sugar (and other) transporter family, has low similarity to solute carrier family 17 member 1 (mouse Slc17a1), which is involved in sodium-dependent phosphate transport and hepatic and renal anion drug transport C01B4.H C01B4.6;C01B4.H Member of the aldose 1-epimerase family, which interconvert aldoses between their alpha- and beta-forms, has low similarity to a region of S. cerevisiae Gal10p, which an UDP-glucose 4-epimerase that catalyzes a step in galactose metabolism C01B4.J C01B4.1;C01B4.J Member of the 7-transmembrane chemoreceptor family of G-protein coupled receptors (GPCR), has low similarity to C. elegans ODR-10, which is a G protein-coupled receptor involved in odorant response C01B7.1 C01B7.1 Protein containing four C2H2 type zinc finger domains, which bind nucleic acids zinc finger protein C01B7.3 C01B7.3 Protein of unknown function C01B7.4 C01B7.4 Protein containing a Src homology 3 (SH3) domain, guanylate kinase domain, and a PDZ, DHR or GLGF domain, has weak similarity to postsynaptic density-95 (mouse Dlgh4), which is a scaffolding protein that recruits neurotransmitter receptors and channels guanylate kinase; This gene encodes a protein predicted by Eisenberg and coworkers, with 68% accuracy, to be mitochondrial. C01B7.5 C01B7.5 Protein containing a PDZ, DHR, or GLGF domain, which are found in signaling proteins C01B7.6 rpm-1;sad-3;syd-3;C01B7.6 Protein involved in pre- and post-synaptic terminal development in motor neurons C01B7.7 C01B7.7 Protein containing a DUF19 domain of unknown function, which contain twelve conserved cysteines, has very strong similarity to uncharacterized C. elegans F07B7.13 C01B9.1 C01B9.1 Protein containing an F-box domain, which serve as a link between a target protein and a ubiquitin-conjugating enzyme, and three DUF38 domains of unknown function, has high similarity to uncharacteriized C. elegans R10E8.6 C01B9.2 C01B9.2 Protein of unknown function that may be anchored to the membrane of a secretory vesicle or the Golgi apparatus C01C10.1 C01C10.1 Putative tetraspan transmembrane protein in an operon with C01C10.1a; similar to human Gas3/PMP22, a member of the growth arrest specific, peripheral myelinating protein family clc-2 encodes a claudin homolog, closely similar to CLC-1, that is required for normal cohesion of apical junctions in epithelia; claudins are integral membrane proteins with four transmembrane sequences that are found in mammalian tight junctions (TJs), induce TJs when transgenically expressed in cells normally lacking them, and can mediate the specific conductance of of specific ions (e.g., magnesium or calcium) through TJs while blocking the flow of water; CLC-2 maintains the impermeability ('barrier function') of epithelia, since clc-1(RNAi) animals have abnormal permeability of the hypodermis to dyes; clc-2 is expressed in hypodermal seam cells, with two diffuse lines of CLC-2 protein. C01C10.2 C01C10.2 Protein of unknown function C01C10.3 C01C10.3 Protein of unknown function, has moderate similarity to uncharacterized C. elegans F08G5.2 C01C10.4 C01C10.4 Putative ortholog of C. elegans C01C10.1b gene product clc-5 encodes a claudin homolog that may be required for normal cohesion of apical junctions in epithelia; CLC-5 is worm-specific, with obvious homologs only in C. elegans; CLC-5 has no obvious function in mass RNAi assays; claudins are integral membrane proteins with four transmembrane sequences that are found in mammalian tight junctions (TJs), induce TJs when transgenically expressed in cells normally lacking them, and can mediate the specific conductance of of specific ions (e.g., magnesium or calcium) through TJs while blocking the flow of water. C01C4.1 C01C4.1 MSFamide neurotransmitter A. californica buccalin precursor (weak); nlp-1 encodes a predicted neuropeptide-like protein of the MSFamide family with similarity to Aplysia californica (sea hare) buccalin, a neuropeptide that regulates acetylcholine-induced muscle contraction; NLP-1 is expressed in the phasmid PHB tail sensory neuron, lateral neurons, head neurons, and the intestine; the precise role of NLP-1 in nervous system function and development is not yet known. C01C4.2 C01C4.2 Protein of unknown function C01C4.3 C01C4.3 Protein containing a protein kinase domain, has low similarity to a region of checkpoint kinase 2 (mouse Rad53), which is a protein kinase that may transmit signals from ataxia telangiectasia mutated kinase (Atm) that are generated after DNA damage serine/threonine protein kinase C01C7.1 ark-1;C01C7.1 Putative tyrosine protein kinase, has similarity to H. sapiens p21cdc42 protein kinase that inhibits p21cdc42, has similarity to D. melanogaster PR2 protein Src homology domain 3, tyrosine-protein kinase (ACK subfamily); ark-1 encodes a homolog of the nonreceptor tyrosine kinase ACK which inhibits signalling through the EGF receptor homolog LET-23, both in (RAS-dependent) vulval development and in (RAS-independent) ovulation. C01F1.1 C01F1.1 Protein with low similarity to general transcription factor IIF polypeptide 1 (human GTF2F1), which is required for transcriptional initiation by RNA polymerase II and stimulates mRNA transcription elongation dna binding protein C01F1.2 C01F1.2 Member of the SCO1-SenC family, which are involved in biogenesis of respiratory and photosynthetic systems, has a region of high similarity to a region of cytochrome oxidase deficient 1 (human SCO1) C01F1.2 is orthologous to the human gene SCO (CYTOCHROME OXIDASE DEFICIENT, YEAST) HOMOLOG 1 (SCO1; OMIM:603644), which when mutated leads to early-onset hepatic failure; the C01F1.2 protein is predicted to be mitochondrial with 68% accuracy. C01F1.3 C01F1.3 Member of the NAD-dependent epimerase or dehydratase family, which catalyze reactions involving nucleotide sugar substrates, has a region of weak similarity to UDP-glucuronate decarboxylase (C. neoformans Uxs1_D) C01F1.4 C01F1.4 Protein of unknown function, has low similarity to uncharacterized C. elegans H02I12.3 C01F1.5 C01F1.5 Protein of unknown function C01F1.6 C01F1.6 Protein containing three ankyrin (Ank) repeats, which may mediate protein-protein interactions, has moderate similarity to uncharacterized human DKFZP566D1346 C01F4.1 C01F4.1 Protein of unknown function C01F4.2 C01F4.2 Protein containing a RhoGAP (GTPase activator protein) domain, has a region of low similarity to a region of rho GTPase activating protein 6 (mouse Arhgap6), which is a multiple splice form GTPase activating protein (GAP) for mouse Arha2 C01F4.3 C01F4.3 Protein of unknown function C01F6.1 C01F6.1 Protein with low similarity to copine 6 (mouse Cpne6), which is a calcium-dependent phospholipid binding protein and may play roles in Ca2+ sensing and neuronal plasticity C01F6.2 C01F6.2 Protein of unknown function C01F6.3 C01F6.3 Member of the cytochrome P450 family, has low similarity to cytochrome P450 4B1 (mouse Cyp4b1), which converts several compounds to active carcinogens and may function in chemical carcinogenesis in extrahepatic tissues C01F6.4 fem-3;isx-3;C01F6.4 Protein involved in somatic sex determination and in spermatogenesis sex-determining protein (FEM-3); fem-3 encodes a novel protein that promotes male development in all tissues. C01F6.5 C01F6.5 Protein with low similarity to S. cerevisiae Yra1p, which has RNA:RNA annealing activity and is involved in mRNA packaging for export from the nucleus RNA recognition motif. (aka RRM, RBD, or RNP domain) C01F6.6 C01F6.6 Protein containing two PDZ, DHR, or GLGF domains, has weak similarity to solute carrier family 9 isoform 3 regulatory factor 1 (sodium-hydrogen exchanger-regulatory factor, human LOC59114), which is a cytoskeleton-linking protein PDZ domain (Also known as DHR or GLGF). C01F6.8 ICln;C01F6.8 Protein with low similarity to swelling-induced chloride conductance regulatory protein (rat Clns1a), which may be a chloride channel regulator that may participate in regulation of chloride transport and cell volume nucleotide-sensitive chloride ion channel; The icl-1 gene encodes, through alternative splicing, two alternative forms (ICL-1A, or 'IClnN1', and ICL-1B, or 'IClnN2'), with distinct electrophysiological properties, of an anion channel homolog. C01F6.9 Nx;C01F6.9 Protein of unknown function, has weak similarity to C. elegans K10B3.1 The C01F6.9 gene resides in an operon that also contains the genes icl-1 and lpl-1. C01G10.1 C01G10.1 Protein containing an ankyrin (Ank) repeat, which may mediate protein-protein interactions, a BRCA1 (breast cancer type 1) C terminus (BRCT) domain, and a WSN domain, has high similarity to uncharacterized C. elegans F26D2.10 ankyrin repeat C01G10.10 C01G10.10 Member of the M22 glycoprotease family, has low similarity to uncharacterized human LOC64172 O-sialoglycoprotein endopeptidase C01G10.11 unc-76;C01G10.11 Protein of the FEZ (Fasciculation and Elongations proteins; Zygin/Zeta-1) family, involved in controlling axon-axon interactions within a fascicle UNC-76 protein C01G10.12 C01G10.12 Protein containing one DnaJ domain, which are part of chaperone (protein folding) system that mediates interaction with heat shock proteins, has a region of moderate similarity to a region of S. cerevisiae Jem1p, which is required for nuclear fusion DNAJ protein; This gene encodes a protein containing a DnaJ ('J') domain. C01G10.13 C01G10.13 Protein with strong similarity to C. elegans T05H4.8 gene product C01G10.14 C01G10.14 Protein containing a major sperm protein (MSP) domain, which are involved in sperm motility C01G10.2 C01G10.2 Protein of unknown function, has high similarity to uncharacterized C. elegans C01G10.3 C01G10.3 C01G10.3 Protein of unknown function, has high similarity to uncharacterized C. elegans C01G10.2 7TM receptor, srx family C01G10.4 C01G10.4 Protein of unknown function C01G10.5 C01G10.5 Protein of unknown function C01G10.6 C01G10.6 Protein of unknown function C01G10.7 C01G10.7 Protein of unknown function citrate lyase beta chain C01G10.8 C01G10.8 Protein of unknown function, has moderate similarity to uncharacterized human C14ORF3 C01G10.9 C01G10.9 Putative ortholog of S. cerevisiae Ypr118p, a protein of unknown function Initiation factor 2 subunit C01G12.1 C01G12.1 Protein of unknown function, has similarity over N-terminal 100 amino acids to D. melanogaster ADF1 (Adh transcription factor 1) C01G12.2 C01G12.2 Protein with moderate similarity to C. elegans C01G12.6 gene product C01G12.3 C01G12.3 Protein of unknown function, has high similarity to uncharacterized C. elegans F44G4.5 C01G12.5 C01G12.5 Member of the short-chain dehydrogenase-reductase family, which are NAD- or NADP-dependent oxidoreductases, has low similarity to hydroxyprostaglandin dehydrogenase 15-NAD (human HPGD), which inactivates prostaglandins by oxidation Alcohol/other dehydrogenases, short chain type; This gene encodes a protein predicted by Eisenberg and coworkers, with 68% accuracy, to be mitochondrial. C01G12.6 C01G12.6 Protein of unknown function, has high similarity to uncharacterized C. elegans F35C5.10 C01G12.7 C01G12.7 Protein of unknown function C01G12.8 C01G12.8 Protein with high similarity to sodium-potassium ATPase alpha subunit (C. elegans EAT-6), member of the haloacid dehalogenase or epoxide hydrolase and the E1-E2 ATPase families, contains cation transporting ATPase N-terminal and C-terminal domains sodium/potasssium transporting ATPase C01G5.2 prg-2;C01G5.2 Protein containing a piwi domain and a PAZ (Piwi, Argonaut and Zwille) domain, which may mediate protein-protein interactions, has low similarity to piwi (Drosophila)-like 1 (human PIWIL1), which functions in control of cell proliferation and apoptosis C01G5.3 C01G5.3 Putative ortholog of C. elegans Y75B7B.1 gene product C01G5.4 C01G5.4 Protein containing a WSN domain of unknown function, has moderate similarity to uncharacterized C. elegans C09B9.7 C01G5.5 C01G5.5 Member of the aldo-keto reductase family, which include some related monomeric NADPH-dependent oxidoreductases, has low similarity to aldose reductase (rat Akr1b1), which reduces glucose and other carbonyl-containing substrates aldehyde reductase C01G5.6 C01G5.6 Member of the retroviral aspartyl protease family, has a region of moderate similarity to a region of S. cerevisiae Ddi1p, which binds to t- and v-SNARE complexes and also interacts with S. cerevisiae Rad23p C01G5.7 C01G5.7 Protein of unknown function C01G5.8 C01G5.8 Protein of unknown function, has low similarity to uncharacterized human KIAA1018 C01G5.9 C01G5.9 Protein with strong similarity to C. elegans C08B6.3 gene product C01G6.1 AQP;C01G6.1;aqp-ce1 Protein with strong similarity to H. sapiens AQP3 (aquaporin 3) glycerol uptake facilitator protein C01G6.2 C01G6.2 Protein with strong similarity to C. elegans Y11D7A.15 gene product C01G6.3 C01G6.3 Protein of unknown function C01G6.4 C01G6.4 Protein containing a C3HC4 type RING zinc finger, which may mediate protein-protein interactions, has moderate similarity to uncharacterized human RNF11 Zinc finger, C3HC4 type (RING finger) C01G6.5 C01G6.5 Protein containing a forkhead associated (FHA) domain, which bind phosphopeptides Forkhead-associated (FHA) domain C01G6.6 C01G6.6 Member of the NADP-cytochrome P450 reductase (tentative) protein family NADPH-ferrihemoprotein reductase C01G6.7 C01G6.7 Member of the AMP-binding enzyme family, has low similarity to S. cerevisiae Fat2p, which is a peroxisomal AMP-binding protein 4-coumarate-coA ligase C01G6.9 C01G6.9 Protein of unknown function C01G8.1 C01G8.1 Protein of unknown function C01G8.2 cln-3.2;C01G8.2 Member of the CLN3 protein family, which are involved in Batten disease, has moderate similarity to ceroid-lipofuscinosis neuronal 3 (human CLN3), which plays a role in lysosomal pH homeostasis cln-3.2 encodes a predicted transmembrane protein that comprises one of three C. elegans homologs of human CLN3 (OMIM:607042, mutations are associated with Batten disease (also known as juvenile neuronal ceroid lipofuscinosis), a recessively inherited childhood neurodegenerative disorder characterized by progressive loss of vision, seizures, and psychomotor abnormalities); by homology, CLN-3.2 is predicted to localize to Golgi and lysosomal membranes, where its proposed functions include that of a chaperone and/or a regulator of intracellular trafficking; in C. elegans, loss of cln-3.2 activity via mutation or RNA-mediated interference (RNAi) does not result in any obvious abnormalities (nor does loss of all three CLN3 homologs, cln-3.1, cln-3.2, and cln-3.3), suggesting that these genes do not play an essential role in development and/or behavior. C01G8.3 C01G8.3 Member of the short-chain dehydrogenase-reductase family, which are NAD- or NADP-dependent oxidoreductases, has low similarity to a region of WW domain-containing oxidoreductase (mouse Wwox), which is an apoptosis activator induced by hyaluronidase oxidoreductase C01G8.4 C01G8.4 Protein containing a DnaJ domain, which are part of the chaperone (protein folding) system that mediates interaction with heat shock proteins This gene encodes a protein containing a DnaJ ('J') domain. C01G8.5 C01G8.5 Protein with high similarity to moesin (human MSN), which is a putative receptor that may link the cytoskeleton and plasma membrane, member of the ezrin, radixin or moesin family, which link actin filaments to the plasma membrane, contains FERM domains membrane protein; The erm-1 gene encodes an ortholog of the ERM family of cytoskeletal linkers with approximately equal similarity to ezrin, radixin and moesin. C01G8.6 C01G8.6 Protein of unknown function, has weak similarity to human dentin phosphoryn and S. cerevisiae Aga1p (a-Agglutinin anchor subunit) C01G8.9 C01G8.9 Putative ortholog of C. elegans C01G8.7 gene product C01H6.1 C01H6.1 Protein containing two collagen triple helix repeats, which are found in some extracellular proteins, and a nematode cuticle collagen N-terminal domain, has a region of high similarity to a region of C. elegans BLI-1 collagen C01H6.2 C01H6.2 Protein containing seven ankyrin (Ank) repeats, which may mediate protein-protein interactions, has a region of low similarity to a region of ankyrin (rat Ank3), which is an anchoring protein that links integral membrane proteins to the cytoskeleton Ank repeat (2 domains); This gene encodes a protein predicted by Eisenberg and coworkers, with 52% accuracy, to be mitochondrial. C01H6.3 C01H6.3 Protein of unknown function C01H6.4 C01H6.4 Member of the flavin-binding monooxygenase family, which are xenobiotic-metabolising enzymes, has low similarity to flavin containing monooxygenase 5 (human FMO5) Flavin-binding monooxygenase-like C01H6.5 nhr-23;NR1F4;chr3;C01H6.5 Member of the retinoic acid receptor (RAR) subfamily of thyroid hormone receptors; involved in cuticle development and molting nuclear hormone receptor; The nhr-23 gene encodes a nuclear hormone receptor homolog that is required in all larval molts; NHR-23 is highly similar to Drosophila DHR3, an ecdysone-inducible gene product involved in metamorphosis; NHR-23 is required for hypodermal expression of acn-1 and, probably, of dpy-7. C01H6.6 C01H6.6 Protein containing a DUF21 domain of unknown function, has weak similarity to a region of S. cerevisiae AMI3, which is required for normal mitochondrial structure C01H6.6 encodes a homolog of human ACDP1-ACDP4 and a paralog of C33D12.2, C52D10.12, M02F4.3, R04E5.2, and R13G10.4; both C01H6.6 and ACDP1-ACDP4 belong to a family of proteins (defined by NCBI as KOG2118) that are predicted to be membrane-spanning and that share a motif (the 'ACD domain') with proteins from bacteria, yeast, plants, and metazoa; murine Acdp1 is a plasma membrane protein bacterial proteins containing the ACD domain include CorC from Salmonella typhimurium, which is involved in magnesium and cobalt efflux; C01H6.6 has no obvious function in RNAi assays. C01H6.7 C01H6.7 Protein containing a bromodomain, which interact specifically with acetylated lysine, has a region of low similarity to a region of C. elegans CBP-1, which is a transcriptional activator,involved in histogenesis and organogenesis Bromodomain C01H6.8 C01H6.8 Protein of unknown function C01H6.9 C01H6.9 Protein containing two protein kinase domains, has a region of low similarity to germ cell-specific gene 2 (haspin) (mouse Gsg2), which is a serine-threonine kinase that binds DNA and may be involved in cell cycle cessation Eukaryotic protein kinase domain; C01H6.9 encodes a homolog of haploid germ cell-specific nuclear protein kinase (haspin) that specifically binds GOA-1 in yeast two-hybrid assays; C01H6.9 is expressed in PHB sensory neurons and PVT interneurons in the tail, several unidentified neurons in the head (with projections to the nose and nerve ring), and intestinal cells, with mainly nuclear localization; C01H6.9 has no obvious function or phenotype in RNAi assays, either alone or with inactivation of a close paralog (F22H10.5). C02A12.1 C02A12.1 Protein containing a glutathione S-transferase N-terminal and C-terminal domains, has low similarity to prostaglandin D2 synthase 2 (rat Ptgds2), which acts as a glutathione S-transferase and a prostaglandin D synthase in prostaglandin D2 biosynthesis glutathione S-transferase C02A12.2 C02A12.2 Protein containing a DUF40 domain of unknown function, which contain four conserved cysteines, and a DUF33 domain of unknown function, has high similarity to uncharacterized C. elegans R03H4.1 C02A12.3 C02A12.3 Protein containing two DUF40 domains of unknown function, which contain four conserved cysteines, has moderate similarity to uncharacterized C. elegans C02A12.5 C02A12.4 C02A12.4 Member of an uncharacterized protein family with weak similarity to Entemeba histolytica N-acetylmuraminidase lys-7 encodes an enzyme homologous to an antimicrobial lysozyme encoded by the LYS4 gene of the protozoan parasite Entamoeba histolytica; by homology, LYS-7 is predicted to function as an antimicrobial enzyme that hydrolyzes the 1,4-beta-linkages between N-acetyl-D-glucosamine and N-acetylmuramic acid in peptidoglycan heteropolymers of prokaryotic cell walls; in C. elegans, lys-7 expression is significantly upregulated in response to infection with the Gram-negative bacterium Serratia marcescens, indicating that LYS-7 likely plays a role in the innate immune response; constitutive expression of lys-7 mRNA is detected in the intestine and the intestinal valve cells. C02A12.5 C02A12.5 Protein containing two DUF40 domains of unknown function, which contain four conserved cysteines, has moderate similarity to uncharacterized C. elegans C02A12.3 C02A12.6 C02A12.6 Protein containing a DUF40 domain of unknown function, which contain four conserved cysteines, has high similarity to uncharacterized C. elegans C07G3.7 C02A12.7 C02A12.7 Protein with strong similarity to C. elegans K07E8.10 gene product C02B10.1 IVD;C02B10.1 Mitochondrial isovaleryl-CoA reductase; functions in leucine metabolism acyl-CoA dehydrogenase; The C02B10.1 gene encodes an isovaleryl-CoA dehydrogenase; this function has been verified by both sequence homology and direct biochemical assay. C02B10.2 C02B10.2 Protein of unknown function C02B10.3 C02B10.3 Protein containing an epidermal growth factor (EGF)-like domain, has a region of low similarity to a region of jagged 1 (rat Jag1), which is a ligand for the Notch receptor that may control cell fate determination, proliferation, and differentiation C02B10.4 C02B10.4 Protein containing an RNA recognition motif (RRM, RBD, or RNP) C02B10.5 C02B10.5 Protein of unknown function, contains proline-rich domains, has weak similarity in the C-terminal portion to the human glutamine rich protein KIAA0181 (Hs.159613) C02B10.6 C02B10.6 Member of the protein-tyrosine phosphatase family, which are involved in cell growth control, proliferation, differentiation and transformation, has moderate similarity to C. elegans F10G8.1, which is involved in embryogenesis or morphogenesis C02B4.1 adt-1;C02B4.1 Member of the reprolysin (M12B) zinc metalloprotease family, contains twelve thrombospondin type 1 domains, involved in male tail morphogenesis TSP type-1 repeats (13); The adt-1 gene encodes a metalloproteinase with disintegrin-like and metalloproteinase with thrombospondin type I motifs (ADAMTS) that is required for male tail morphogenesis. C02B4.2 nhr-17;C02B4.2 Member of the nuclear hormone receptor/Zinc finger protein family nuclear hormone receptor C02B4.3 C02B4.3 Protein of unknown function C02B8.1 C02B8.1 Protein with strong similarity to C. elegans ZK507.6 gene product C02B8.2 C02B8.2 Putative ortholog of C. elegans F31A9.4 gene product C02B8.3 C02B8.3 Protein of unknown function, has high similarity to uncharacterized C. elegans F58E10.7 C02B8.4 hlh-8;bHLH-8;CeTwist;C02B8.4 Helix-loop-helix DNA-binding domain family member; involved in the development and differentiation of several different mesoderm-derived cells MYC family of helix-loop-helix transcription factors; The hlh-8 gene encodes a helix-loop-helix protein required for normal muscle development, and hence for normal defecation and egg-laying. C02B8.5 C02B8.5 Protein with strong similarity to C. elegans K07E8.5 gene product C02B8.5 encodes a homolog of the functionally active Fmrf Receptor (FR; CG2114) of D. melanogaster; it is thus possible that C02B8.5 is a receptor for one of the FMRF-like neurotransmitters in C. elegans (e.g., FLP-1 through FLP-12). C02B8.6 C02B8.6 Protein containing two C3HC4 type RING zinc fingers, which may mediate protein-protein interactions, and two WWE domains, which may mediate protein interactions in ubiquitin and ADP ribose conjugation systems DNA repair protein RAD16 (yeast, weak) C02B8.7 C02B8.7 Protein with moderate similarity to C. elegans C02B8.3 gene product C02C2.2 C02C2.1;C02C2.2 Protein containing a tyrosinase central domain, which are copper-binding domains, has high similarity to uncharacterized C. elegans K08E3.1 C02C2.3 C02C2.3 Protein containing a neurotransmitter-gated ion-channel ligand binding domain, has weak similarity to muscle cholinergic receptor nicotinic alpha subunit 1 (mouse Chrna1), which contains major binding sites for acetylcholine Acetylcholine receptor; The primary phenotype of cup-4 animals is an accumulation of secreted GFP in the pseudocoelom, suggesting a decrease in, or the absence of, endocytosis in coelomocytes. C02C2.4 C02C2.4 Protein with similarity to human and D. melanogaster sodium-dependent inorganic phosphate cotransporters, member of the major facilitator superfamily C02C2.5 C02C2.5 Member of the nitroreductase family, which utilize FMN as a cofactor C02C6.1 dyn-1;C02C6.1 Dynamin dynamin C02C6.2 C02C6.2 Protein of unknown function C02C6.3 C02C6.3 Protein containing four leucine rich repeats, which mediate protein-protein interactions, and a leucine rich repeat C-terminal cysteine rich domain, has weak similarity to trophoblast glycoprotein (human TPBG), which is a cells surface antigen Leucine Rich Repeat (2 copies) C02D4.1 C02D4.1 Protein of unknown function C02D4.2 C02D4.2 Member of the rhodopsin family of G protein-coupled receptors (GPCR), has low similarity to 5-hydroxytryptamine (serotonin) 1A receptor (rat Htr1a), which inhibits adenylyl cyclase and plays a role in anxiety, nociception, sleep and feeding behavior octopamine receptor; ser-2 encodes at least four tyramine 7-transmembrane domain receptors (GPCRs), by alternative splicing from three different promoters, that have distinct but partially overlapping expression patterns; ser-2 has at least three alternative promoters that drive SER-2 expression in a set of sensory, inter- and motor neurons (e.g., AIY, AIZ, and RIA) adding up to ~10% of all neurons in the nervous system, as well as pharyngeal cells and head muscles; the deletion ser-2(pk1397) has no obvious mutant phenotype; LIM-4 is required for SER-2 expression, and MAB-23 is required for SER-2 expression at normally high levels. C02D5.1 C02D5.1 Protein containing an acyl-CoA dehydrogenase N-terminal, middle, and C-terminal domains, has low similarity to long-chain acyl-Coenzyme A dehydrogenase (rat Acadl), which catalyzes the first step in mitochondrial fatty acid beta-oxidation Isovaleryl-CoA dehydrogenase C02D5.2 C02D5.2 Protein with strong similarity to C. elegans ZK669.2 gene product C02D5.3 C02D5.3 Protein containing glutathione S-transferase N-terminal and C-terminal domains, has a region of high similarity to a region of glutathione S-transferase omega 1 (mouse Gsto1), which binds glutathione and functions as a stress response protein C02E11.1 C02E11.1 Putative ortholog of human pM5 protein (Hs.75663), a putative member of the collagenase gene family C02E7.1 C02E7.1 Member of the E1-E2 (P-type) ATPase family and the haloacid dehalogenase or epoxide hydrolase family, contains cation transporting ATPase N-terminal and C-terminal domains, has moderate similarity to alpha subunit of non-gastric H,K ATPase (human ATP12A) sodium/potassium-transporting ATPase alpha-2 chain C02E7.10 C02E7.10 Protein with strong similarity to C. elegans C24B9.9 gene product C02E7.13 C02E7.13 Member of the 7-transmembrane chemoreceptor family of G protein-coupled receptors (GPCR), has low similarity to C. elegans ODR-10, which is involved in odorant response 7TM chemoreceptor, str family C02E7.14 C02E7.14 Protein of unknown function, has high similarity to uncharacterized C. elegans T05F1.12 C02E7.2 C02E7.2 Protein of unknown function, has high similarity to uncharacterized C. elegans C02E7.4 7TM chemoreceptor, srh family C02E7.3 C02E7.3 Protein of unknown function, has high similarity to uncharacterized C. elegans C02E7.4 7TM chemoreceptor, srh family C02E7.4 C02E7.4 Member of the 7-transmembrane chemoreceptor family of G protein-coupled receptors (GPCR), has high similarity to uncharacterized C. elegans C02E7.5 7TM chemoreceptor, srh family C02E7.5 C02E7.5 Protein of unknown function, has high similarity to uncharacterized C. elegans C02E7.4 7TM chemoreceptor, srh family C02E7.6 C02E7.6 Protein of unknown function, has weak similarity to C. elegans C02E7.7 C02E7.7 C02E7.7 Protein of unknown function, has weak similarity to C. elegans C02E7.6 C02E7.8 C02E7.8 Protein of unknown function C02E7.9 C02E7.9 Member of the 7-transmembrane chemoreceptor family of G protein-coupled receptors (GPCR), has low similarity to C. elegans ODR-10, which is involved in odorant response 7TM chemoreceptor, str family C02F12.1 C02F12.1 Member of the tetraspanin family, which contain an N-terminal transmembrane domain that is a signal sequence and membrane anchor, has weak similarity to uncharacterized melanoma 1 antigen (mouse Cd63) transpanin C02F12.3 C02F12.3 Protein of unknown function C02F12.4 C02F12.4 Protein containing a RhoGEF (GTPase exchange factor) domain, has a region of low similarity to a region of FGD1 related F actin binding protein (rat frabin), which is an actin crosslinking protein that activates Cdc42, Rac (Akt) and Jun kinase (Serk2) guanine-nucleotide releasing factor of the CDC24 family C02F12.5 C02F12.5 Homeodomain transcription factor, has similarity over the homeodomain to many human and D. melanogaster homeodomain transcription factors homeobox; tissue factor pathway inhibitor C02F12.7 C02F12.7 Putative coiled-coil protein, has similarity to human CENPE, centromere protein E C02F12.8 C02F12.8 Protein of unknown function breast cancer type 1 susceptibility protein (BRCA1) C02F12.9 C02F12.9 Protein of unknown function C02F4.1 ced-5;C02F4.1 Protein required for cell corpse engulfment and distal tip cell migration DOCK180 protein; The ced-5 gene a homolog of the human protein DOCK180 that is required for the cell engulfment stage of programmed cell death. C02F4.2 PP2B;C02F4.2 Protein with high similarity to calcineurin A alpha (rat Ppp3ca), which is the catalytic subunit of calcium/calmodulin regulated protein phosphatase that regulates the activity of transcription factors, member of the serine or threonine phosphatase family serine/threonine protein phosphatase; tax-6 encodes an ortholog of calcineurin A that is required for inhibition and adaptation of several sensory neurons and for the normal regulation of egg-laying by serotonin; TAX-6 stimulates transcription of rcn-1, and binds RCN-1 protein if free Ca[2+] is present; in general, calcineurin positively regulates calcium-dependent signaling. C02F4.3 C02F4.3 Protein of unknown function C02F4.4 C02F4.4 Protein of unknown function C02F4.5 C02F4.5 Protein of unknown function C02F5.1 C02F5.1 Putative coiled-coil protein, has weak similarity to human early endosome antigen EEA1 knl-1 encodes a novel acidic protein with a coiled-coil region at its C-terminus; KNL-1 is an essential kinetochore component that is required for proper spindle elongation and chromosome separation, and in the kinetochore assembly pathway, plays a key role in linking the initiation of kinetochore formation with the construction of a functional microtubule-binding interface; in the assembly pathway, KNL-1 functions downstream of the DNA-proximal kinetochore components CeCENP-A/HCP-3 and CeCENP-B/HCP-4 and upstream of the outer kinetochore components HIM-10/Nuf2p, NDC-80/HEC1, CeBUB-1, HCP-1, and CeCLASP2/CLS-2; in expression studies in the one-cell embryo, KNL-1 localizes to kinetochores throughout mitosis. C02F5.10 C02F5.10 Protein with moderate similarity to C. elegans C02F5.2 gene product C02F5.11 C02F5.11 Protein with strong similarity to C. elegans C02F5.8 gene product tetraspanin C02F5.12 C02F5.12 Protein with strong similarity to C. elegans T07G12.13 gene product C02F5.2 C02F5.2 Protein with moderate similarity to C. elegans C02F5.10 gene product C02F5.3 C02F5.3 Putative GTP-binding protein GTP-binding protein; This gene encodes a protein predicted by Eisenberg and coworkers, with 52% accuracy, to be mitochondrial. C02F5.4 C02F5.4 Protein of unknown function, has weak similarity to uncharacterized human FLJ10656 C02F5.5 C02F5.5 Protein of unknown function, has high similarity to uncharacterized C. elegans F17E9.5 C02F5.6 C02F5.6 Protein of unknown function C02F5.8 C02F5.8 Member of the tetraspanin family, which contain an N-terminal transmembrane domain that is a signal sequence and membrane anchor, has moderate similarity to uncharacterized C. elegans C02F5.11 tetraspanin C02F5.9 pbs-6;C02F5.9 Putative beta-type subunit of 20S proteasome particle Proteasome component C5; The pbs-6 gene encodes a homolog of mammalian PSMB1. C02G6.1 C02G6.1 Member of the insulinase (peptidase M16) family, has moderate similarity to insulin-degrading enzyme (insulysin, rat Ide), which is a metallopeptidase that degrades insulin, amyloid beta (rat App), insulin-like growth factors, and natriuretic peptides peptidase; This gene encodes a protein predicted by Eisenberg and coworkers, with 68% accuracy, to be mitochondrial. C02G6.2 C02G6.2 Member of the insulinase (peptidase M16) family, has moderate similarity to insulin-degrading enzyme (receptor accessory factor, insulinase, human IDE), which is a peptidase that may have a role in sex differentiation peptidase; This gene encodes a protein predicted by Eisenberg and coworkers, with 68% accuracy, to be mitochondrial. C02H6.1 C02H6.1 Member of the galactosyltransferase family, which transfer galactose to GlcNAc termini of growing oligosaccharide chains, has high similarity to uncharacterized C. elegans F56H6.1 C02H6.2 C02H6.2 Protein containing an F-box domain, which serve as a link between a target protein and a ubiquitin-conjugating enzyme, and a DUF38 domain of unknown function, has low similarity to C. elegans FOG-2, which is required for the sexual identity of germ cells This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins; this gene's encoded protein also contains an FTH/DUF38 motif, which may also mediate protein-protein interaction. C02H7.1 C02H7.1 Putative coiled-coil protein, has weak similarity to myosin heavy chains C02H7.2 C02H7.2 Member of the rhodopsin family of G protein-coupled receptors (GPCR), has weak similarity to a region of central cannabinoid receptor 1 (human CNR1), which signals through an inhibitory G protein C02H7.3 aex-3;C02H7.3 Regulator of presynaptic activity related to the defecation cycle; putative ortholog of human MAP-kinase activating death domain protein MADD The aex-3 gene encodes a guanine nucleotide exchange factor for the rab-3 GTPase that is orthologous to human MAP kinase activating protein containing death domain (MADD, OMIM:603584); AEX-3 is required for intracellular vesicle trafficking as well as synaptic vesicle release and interacts with CAB-1 and RAB-3 to regulate separate pathways for neural activities such as defecation and male mating, respectively; AEX-3 is also required for egg laying and locomotion; AEX-3 is expressed in nearly all neurons. C03A3.1 C03A3.1 Protein of unknown function C03A3.2 C03A3.2 Protein of unknown function C03A3.3 C03A3.3 Member of the metallo-beta-lactamase family C03A7.1 C03A7.1 Protein of unknown function, has high similarity to uncharacterized C. elegans ZK228.2 C03A7.10 C03A7.10 Putative ortholog of C. elegans C03A7.9 gene product 7TM chemoreceptor, srt family C03A7.11 C03A7.11 Protein containing a UDP-glucoronosyl and UDP-glucosyl transferase domain, has weak similarity to olfactory UDP-glucuronosyltransferase (human UGT2A1), which catalyzes the glucuronidation of substrates including odorants, steroids, drugs, and carcinogens C03A7.12 C03A7.12 Protein containing a UDP-glucoronosyl and UDP-glucosyl transferase domain, which transfer glycosyl groups to small hydrophobic molecules C03A7.13 C03A7.13 Putative ortholog of C. elegans C03A7.11 gene product C03A7.14 C03A7.14 Protein containing ten uncharacterized DUF139 cysteine repeat domains, has very strong similarity to uncharacterized C. elegans C03A7.8 abu-8 encodes a transmembrane protein with a predicted signal sequence, a glutamine/asparagine-rich domain and multiple cysteine-rich repeats (DUF139); abu-8 expression is induced by blockage of the unfolded-protein response in the endoplasmic reticulum, and ABU-8 may help protect the organism from damage by improperly folded nascent protein. C03A7.2 C03A7.2 Protein of unknown function, has moderate similarity to uncharacterized C. elegans F07B7.2 C03A7.3 C03A7.3 Protein of unknown function, has high similarity to uncharacterized C. elegans C44C3.7 7TM chemoreceptor, srw family C03A7.4 C03A7.4 Protein containing nine uncharacterized DUF139 cysteine repeat domains, has very strong similarity to uncharacterized C. elegans C03A7.7 The protein product of this gene is predicted to contain a glutamine/asparagine (Q/N)-rich ('prion') domain, by the algorithm of Michelitsch and Weissman (as of the WS77 release of WormBase, i.e., in wormpep77). C03A7.5 C03A7.5 Member of the rhodopsin family of G protein-coupled receptors (GPCR), has high similarity to uncharacterized C. elegans C03A7.6 7TM chemoreceptor, srx family C03A7.6 C03A7.6 Protein of unknown function, has high similarity to uncharacterized C. elegans C03A7.5 7TM chemoreceptor, srx family C03A7.7 C03A7.7 Protein containing nine uncharacterized DUF139 cysteine repeat domains, has very strong similarity to uncharacterized C. elegans C03A7.4 abu-6 encodes a transmembrane protein with a predicted signal sequence, a glutamine/asparagine-rich domain and multiple cysteine-rich repeats (DUF139); abu-6 expression is induced by blockage of the unfolded-protein response in the endoplasmic reticulum, and ABU-6 may help protect the organism from damage by improperly folded nascent protein. C03A7.8 C03A7.8 Protein containing ten uncharacterized DUF139 cysteine repeat domains, has very strong similarity to uncharacterized C. elegans C03A7.14 abu-7 encodes a transmembrane protein with a predicted signal sequence, a glutamine/asparagine-rich domain and multiple cysteine-rich repeats (DUF139); abu-7 expression is induced by blockage of the unfolded-protein response in the endoplasmic reticulum, and ABU-7 may help protect the organism from damage by improperly folded nascent protein. C03A7.9 C03A7.9 Protein of unknown function, has high similarity to uncharacterized C. elegans T28A11.15 7TM chemoreceptor, srt family C03B1.1 C03B1.1 Protein of unknown function C03B1.10 C03B1.10 Protein of unknown function C03B1.12 lmp-1;C03B1.12 Protein of unknown function that appears to be a component of acidic and lysosomal-like C. elegans gut granules; has similarity to H. sapiens macrophage glycoprotein LAMP/CD68 lmp-1 encodes a protein with similarity to vertebrate lysosome-associated membrane proteins CD68, and appears to be the only protein in C. elegans that has a GYXX (phi) vertebrate lysosomal targeting sequence at its carboxy terminus; localized to the periphery of a large population of membrane bound organelles (granules) seen throughout the early embryos and restricted to the cells of the intestine during later stages. C03B1.13 C03B1.13 Protein with moderate similarity to C. elegans Y37A1A.3 gene product C03B1.14 C03B1.14 Putative ortholog of C. elegans C03B1.8 gene product C03B1.2 C03B1.2 Protein of unknown function C03B1.3 C03B1.3 Protein of unknown function, has weak similarity to C. elegans C03B1.4 C03B1.4 C03B1.4 Protein of unknown function, has weak similarity to C. elegans C03B1.3 transposase C03B1.5 C03B1.5 Protein containing two protein kinase domains, has low similarity to a region of serine-threonine kinase 24 (human STK24), which is a serine-threonine kinase that prefers manganese as a cofactor protein kinase C03B1.6 C03B1.6 Protein of unknown function C03B1.7 C03B1.7 Protein of unknown function C03B1.9 C03B1.9 Protein of unknown function C03B8.1 C03B8.1 Protein of unknown function C03B8.2 C03B8.2 Protein of unknown function, has strong similarity to uncharacterized C. elegans C04C3.4 C03B8.3 C03B8.3 Protein of unknown function C03B8.4 lin-13;C03B8.4 Part of the class B pathway that antagonizes vulval induction, member of the zinc finger, C2H2 type protein family Zinc finger; Gene Function : lin-13 encodes a large (2248-residue) nuclear protein with multiple zinc fingers of the C2H2 class and a LXCXE retinoblastoma protein-binding motif, that is required for survival through larval development and for negative regulation of vulval fates during postembryonic development. C03C10.1 kin-19;C03C10.1 Putative casein kinase 1, appears to regulate polarity of the EMS blastomere casein Kinase I; kin-19 encodes a serine/threonine kinase orthologous to human casein kinase I, alpha 1 (CSNK1A1, OMIM:600505); KIN-19 appears to be a component of the non-canonical Wnt signaling pathway that regulates endoderm formation in the early embryo; kin-19(RNAi) and mom-2(RNAi) enhance apr-1(RNAi), but not RNAi of each other. C03C10.2 C03C10.2 Protein containing a protein kinase domain, has a region of low similarity to a region of casein kinase 1 delta (rat Csnk1d), which is a serine/threonine protein kinase possibly involved in DNA repair serine/threonine kinase C03C10.3 C03C10.3 Has high similarity to ribonucleotide reductase subunit M2 (mouse Rrm2), which associates with mouse Rrm1 to yield an enzyme that reduces ribonucleotides to deoxyribonucleotides, member of the ribonucleotide reductase small chain family Ribonuclease-diphosphate reductase M2; This gene encodes a protein predicted by Eisenberg and coworkers, with 52% accuracy, to be mitochondrial. C03C10.4 C03C10.4 Protein with moderate similarity to C. elegans K03E6.7 gene product C03C10.5 C03C10.5 Protein of unknown function C03C10.6 C03C10.6 Protein of unknown function C03C11.1 C03C11.1 Protein containing a DUF236 domain of unknown function, has high similarity to uncharacterized C. elegans F27C1.3 C03C11.2 fog-3;C03C11.2 Protein required for the sexual identity of germ cells; has weak similarity to the H. sapiens Hs.79558 gene product C03D6.1 C03D6.1 Protein with moderate similarity to C. elegans C04F12.1 gene product C03D6.2 C03D6.2 Protein may be involved in RNA processing C03D6.3 cel-1;C03D6.3 Capping enzyme component with RNA 5'-triphosphatase and guanylyltransferase activity mRNA capping enzyme; cel-1 encodes a mRNA capping enzyme, with a N-terminal region with RNA triphosphatase activity and a C-terminal region containing motifs found in yeast and vaccinia virus capping enzyme guanylytransferases; cel-1 is required for embryonic viability, body morphology, and vulval development. C03D6.4 C03D6.4 Putative nucleoporin, has similarity to human nucleoporin NUP214 nucleoporin; npp-14 is orthologous to the human gene NUCLEOPORIN, 214-KD (NUP214; OMIM:114350), which encodes part of the nucleopore complex mediating nucleocytoplasmic transport; NUP214, as a fusion gene with DEK (OMIM:125264), is found in a subset of acute myeloid leukemia. C03D6.5 C03D6.5 Protein with low similarity to S. cerevisiae Asf1p, which is a component of replication-coupling chromatin assembly factor and a target of the S. cerevisiae Rad53p-dependent DNA damage response anti-silencing protein C03D6.6 C03D6.6 Protein of unknown function C03D6.8 C03D6.8 Protein with strong similarity to S. cerevisiae Ylr009p, a predicted ribosomal protein ribosomal protein; rpl-24.2 encodes a large ribosomal subunit L24 protein paralog; its orthologs include ribosomal protein L30 isologs from mammals and 'Ribosomal Like Protein 24' (Rlp24p) from S. cerevisiae; it therefore appears to actually represent an ancient paralogy between two varieties of eukaryotic L24 protein. C03E10.1 C03E10.1 Protein with strong similarity to C. elegans T03F7.6 gene product C03E10.2 C03E10.2 TcA transposase Tc1 transposase C03E10.3 C03E10.3 Protein of unknown function C03E10.4 mgat2;C03E10.4 Protein with moderate similarity to UDP-N-acetylglucosamine: alpha-6-D-mannoside-beta-1,2- N-acetylglucosaminyltransferase II (human MGAT2), which catalyzes the conversion of oligomannose to complex N-glycans UDP-GlcNAc:a-6-D-mannoside b1,2-N-acetylglucosaminyltransferase II; gly-20 is orthologous to the human gene MANNOSYL (ALPHA-1,6-)-GLYCOPROTEIN BETA-1,2-N-ACETYLGLUCOSAMINYLTRANSFERASE (MGAT2; OMIM:602616), which when mutated leads to carbohydrate-deficient glycoprotein syndrome, type II. C03E10.5 C03E10.5 Member of the C-type lectin family C03E10.6 C03E10.6 Protein with similarity to members of the C-type lectin family C03F11.1 C03F11.1 Member of the novel 6 TM potassium channel protein family noninactivating potassium channel (weak) C03F11.2 C03F11.2 Protein with moderate similarity to C. elegans C23H3.9 gene product C03F11.3 C03F11.3 Member of the CD36 family of putative scavenger receptors, has low similarity to CD36 antigen (human CD36), which is an integral membrane receptor that plays roles in cell adhesion, transport and receptor mediated functions glycoprotein C03F11.4 C03F11.4 Putative ortholog of C. elegans Y20C6A.3 gene product C03G5.1 C03G5.1 Protein with high similarity to succinate dehydrogenase complex subunit A (human SDHA), which is an electron transporter in the TCA cycle, contains a FAD binding domain and a fumarate reductase or succinate dehydrogenase flavoprotein C-terminal domain succinate dehydrogenase flavoprotein subunit; C03G5.1 is orthologous to the human gene SUCCINATE DEHYDROGENASE COMPLEX, SUBUNIT A, FLAVOPROTEIN (SDHA; OMIM:600857), which when mutated leads to complex II mitochondrial respiratory chain deficiency presenting as Leigh syndrome. C03G5.2 C03G5.2 Putative ortholog of C. elegans F42F12.6 gene product C03G5.7 flp-5;C03G5.7 Putative FMRF-amide neurotransmitters flp-5 encodes a predicted FMRFamide-like peptide neurotransmitter that increases action potential frequency in the pharyngeal muscle when applied to the pharynx of dissected worms; expressed in the sensory neurons ASE and PVM. C03G6.1 C03G6.1 Protein of unknown function, has low similarity to uncharacterized C. elegans K09D9.10 C03G6.10 C03G6.10 Protein containing two nuclear hormone receptor C4-type zinc finger domains, which bind DNA and may be involved in transcription regulation, and a nuclear hormone receptor ligand-binding domain, has weak similarity to C. elegans NHR-51 C4-type zinc finger protein C03G6.11 C03G6.11 Member of the 7-transmembrane chemoreceptor family of G protein-coupled receptors (GPCR), has high similarity to uncharacterized C. elegans F07C4.14 7TM chemoreceptor, srh family C03G6.12 C03G6.12 Protein containing a nuclear hormone receptor ligand-binding domain and a nuclear hormone receptor C4-type zinc finger domain, which bind DNA and may be involved in regulation of transcription, has weak similarity to mouse Nr6a1 C4-type zinc finger protein C03G6.13 C03G6.13 Protein containing a DUF18 domain of unknown function C03G6.14 C03G6.14 Member of the cytochrome P450 family, has low similarity to nicotine C-oxidase (cytochrome P450 2A6, human CYP2A6), which functions in oxidizing precarcinogens and drugs and may be associated with lung cancer risk C03G6.15 C03G6.15 Member of the cytochrome P450 family, has low similarity to cytochrome P450 subfamily IIC (mephenytoin 4-hydroxylase) polypeptide 8 (human CYP2C8), which is a heme-binding monooxygenase that metabolizes steroids, fatty acids, and xenobiotics cytochrome P450 C03G6.16 C03G6.16 Protein of unknown function, has moderate similarity to uncharacterized C. elegans Y62E10A.4 7TM chemoreceptor, srsx family C03G6.17 C03G6.17 Protein of unknown function, has high similarity to uncharacterized C. elegans T24A6.20 C03G6.18 C03G6.18 Member of the serpin family of serine protease inhibitors, has low similarity to serine (or cysteine) proteinase inhibitor (clade I (neuroserpin) member 2, human SERPINI2), which inhibits breast tumor metastasis serine protease inhibitor; srp-5 encodes an ovalbumin-like serpin (ov-serpin) member of the serine protease inhibitor superfamily; by homology, SRP-5 is predicted to function as a suicide substrate that inhibits the proteolytic activity of serine proteases; however, as loss of srp-5 function via RNA-mediated interference (RNAi) does not result in any obvious abnormalities, the precise role of SRP-5 in C. elegans development and/or behavior is not yet known. C03G6.19 C03G6.19 Member of the serpin family of serine protease inhibitors, has low similarity to squamous cell carcinoma antigen 2 (human SERPINB4), which inhibits chymotrypsin-like serine proteases and serves as a predictive marker for squamous cell carcinomas serine protease inhibitor C03G6.2 C03G6.2 Protein of unknown function, has high similarity to uncharacterized C. elegans K07C6.11 7TM chemoreceptor, srx family C03G6.20 C03G6.20 Putative ortholog of C. elegans ZK105.2 gene product C03G6.3 C03G6.3 Member of the 7-transmembrane chemoreceptor family of G protein-coupled receptors (GPCR), has low similarity to C. elegans ODR-10, which is a G protein-coupled receptor involved in odorant response 7TM chemoreceptor, srj family C03G6.4 C03G6.4 Protein containing two DUF19 domains of unknown function, which contain twelve conserved cysteines, has high similarity to uncharacterized C. elegans C36C5.1 C03G6.5 C03G6.5 Protein containing a DUF19 domain of unknown function, which contain twelve conserved cysteines, has high similarity to uncharacterized C. elegans C36C5.14 C03G6.6 C03G6.6 Member of the domain of unknown function DUF13 family, has high similarity to uncharacterized C. elegans C04F1.1 C03G6.7 C03G6.7 Member of the 7-transmembrane chemoreceptor family of G protein-coupled receptors (GPCR), has high similarity to uncharacterized C. elegans C32B5.2 7TM chemoreceptor, srh family C03G6.8 C03G6.8 Protein containing two nuclear hormone receptor C4-type zinc finger domains, which bind DNA and may be involved in transcription regulation, and a nuclear hormone receptor ligand-binding domain, has weak similarity to C. elegans NHR-51 C03G6.9 C03G6.9 Member of the 7-transmembrane chemoreceptor family of G protein-coupled receptors (GPCR), has high similarity to uncharacterized C. elegans F37B4.3 7TM chemoreceptor, srh family C03H12.1 C03H12.1 Putative ortholog of C. elegans ZK662.1 gene product C03H5.1 C03H5.1 Member of the C-type lectin family, has similarity to human C-type mannose receptor MRC1, has similarity to D. melanogaster TOLKIN protein C03H5.2 C03H5.2 Protein with high similarity to solute carrier family 35 (UDP-N-acetylglucosamine(UDP-GlcNAc) transporter) member 3 (human SLC35A3), which transports nucleotide sugars C03H5.3 C03H5.3 Protein of unknown function C03H5.4 C03H5.4 Member of the phospholipase A2 family, has a region of moderate similarity to a region of group IIA phospholipase A2 (rat Pla2g2a), which is a secreted phospholipase that hydrolyzes the phospholipid sn-2 ester bond and has a role in host defense phospholipase C03H5.5 C03H5.5 Protein with strong similarity to C. elegans C17G10.9 gene product C03H5.6 C03H5.6 Protein containing a BTB (BR-C, ttk and babor) or POZ (Pox virus and zinc finger) domain, which are found in some DNA and actin binding proteins and may mediate protein-protein interactions C03H5.7 C03H5.7 Protein with moderate similarity to C. elegans Y40H7A.9 gene product C04A11.1 C04A11.1 Protein of unknown function C04A11.2 C04A11.2 Protein of unknown function C04A11.3 C04A11.3 Protein containing a protein kinase domain, has low similarity to serine-threonine kinase 2 (mouse Stk2), which undergoes cleavage by caspase 3 (Casp3) during apoptosis thereby releasing an N-terminal kinase domain and a C-terminal domain serine/threonine kinase C04A11.4 adm-2;C04A11.4 Member of the reprolysin (M12B) zinc metalloprotease family, contains a disintegrin domain, has low similarity to meltrin alpha (mouse Adam12), which has cell adhesion and metalloproteinase activity and is involved in muscle cell differentiation zinc metalloprotease; adm-2 encodes a protein containing a snake venom disintegrin-domain and a metalloprotease-like domain (i.e., a protein of the ADAM family); like ADM-1, ADM-2 is homologous to a mammalian sperm glycoprotein (PH-30/fertilin) implicated in sperm-egg fusion, and ADM-2 might thus be a fusogenic protein mediating the merging of plasma membranes during development. C04A2.1 C04A2.1 Protein of unknown function, has weak similarity to S. cerevisiae Msb3p and Msb4p, multicopy suppressor of bud emergence mutants C04A2.3 egl-27;C04A2.3 Protein required for cell polarity and cell migration that is similar to a mammalian metastasis-associated factor egl-27 encodes a homolog of human MTA1, part of an ATP-dependent complex with nucleosome remodelling and histone deacetylation activities that may promote tumor metastasis; in conjunction with its paralog egr-1, egl-27 is required for proper organization in all parts of the embryo, and for the embryonic expression of hlh-8. C04A2.7 C04A2.7 Protein containing five DnaJ domains, which are part of chaperone (protein folding) system that mediates interaction with heat shock proteins, has a region of low similarity to a region of human DRIP78, which is a dopamine receptor interacting protein This gene encodes a protein containing a DnaJ ('J') domain. C04B4.1 C04B4.1 Putative ortholog of C. elegans B0513.1 gene product C04B4.2 C04B4.2 Protein of unknown function, has moderate similarity to uncharacterized C. elegans C04B4.4 C04B4.3 C04B4.3 Member of the class 2 lipase family, has high similarity to uncharacterized C. elegans F45E6.4 lipase C04B4.4 C04B4.4 Protein of unknown function, has moderate similarity to uncharacterized C. elegans C04B4.2 C04B4.5 C04B4.5 Protein of unknown function C04B4.6 C04B4.6 Protein of unknown function C04C11.1 C04C11.1 Protein of unknown function C04C11.2 C04C11.2 Protein with moderate similarity to C. elegans T12D8.4 gene product C04C11.3 C04C11.3 Protein with weak similarity to H. sapiens KIAA0464 (KIAA0464 gene product) C04C3.1 C04C3.1 Protein containing a DUF216 domain of unknown function, has low similarity to uncharacterized C. elegans Y102A5C.23 7TM chemoreceptor, srz family C04C3.2 C04C3.2 Protein containing a neurotransmitter-gated ion-channel ligand binding domain, has low similarity to acetylcholine receptor alpha 10 subunit (rat Chrna10), which plays a role in cholinergic signaling channel protein C04C3.3 C04C3.3 Protein with high similarity to E1 beta subunit of pyruvate dehydrogenase complex (human PDHB), which oxidatively decarboxylates pyruvate to acetyl-CoA, contains a transketolase pyridine binding domain and a transketolase C-terminal domain pyruvate dehydrogenase; This gene encodes a protein predicted by Eisenberg and coworkers, with 52% accuracy, to be mitochondrial. C04C3.4 C04C3.4 Protein of unknown function, has strong similarity to unchracterized C. elegans T07F10.5 C04C3.5 C04C3.5 Protein with strong similarity to human Hs.155995 gene product, cDNA KIAA0643 isolated from a brain cDNA library C04C3.6 C04C3.6 Protein of unknown function, has moderate similarity to uncharacterized C. elegans C50H11.13 C04C3.7 C04C3.7 Protein of unknown function, has a region of low similarity to a region of C. elegans ODR-10, which is a G protein-coupled receptor that is involved in odorant response C04E12.1 C04E12.1 Protein containing a DUF40 domain of unknown function, which contain four conserved cysteines, has high similarity to uncharacterized C. elegans C18B10.3 C04E12.10 C04E12.10 Protein of unknown function, has high similarity to uncharacterized C. elegans C17B7.5 C04E12.11 C04E12.11 Protein of unknown function, has a region of low similarity to a region of vitamin D-3 upregulated protein-1 (mouse Txnip), which is induced by oxidative stress and functions as an oxidative stress mediator by inhibiting thioredoxin activity C04E12.12 C04E12.12 Protein of unknown function, has a region of low similarity to a region of vitamin D-3 upregulated protein-1 (human TXNIP), which binds to and inhibits the activity of thioredoxin and may thereby contribute to cellular redox mechanisms C04E12.2 C04E12.2 Protein containing a DUF19 domain of unknown function, which contain twelve conserved cysteines, has moderate similarity to uncharacterized C. elegans C17B7.4 C04E12.3 C04E12.3 Protein of unknown function, has moderate similarity to uncharacterized C. elegans T20D4.4 C04E12.4 C04E12.4 Protein of unknown function, has high similarity to uncharacterized C. elegans C17D12.3 C04E12.5 C04E12.5 Protein of unknown function, has high similarity to uncharacterized C. elegans F35F10.4 C04E12.6 C04E12.6 Protein of unknown function, has high similarity to uncharacterized C. elegans F35F10.7 C04E12.7 C04E12.7 Protein with moderate similarity to plasma membrane phospholipid scramblase 1 (human PLSCR1), which mediates Ca2+-dependent movement of membrane phospholipids in activated, injured, or apoptotic cells and is a substrate of tyrosine kinase c-Abl C04E12.7 encodes a homolog of human scramblase (PLSCR1; OMIM:604170), which is activated by a rise of intracellular calcium, and which promotes the exposure of phosphatidylserine on the surface of cells undergoing activation, injury, or apoptosis; closely related paralogs of C04E12.7 include T22H2.5 and ZK1053.5. C04E12.8 C04E12.8 Protein of unknown function, has strong similarity to uncharacterized C. elegans F49C5.2 7TM chemoreceptor, srx family C04E12.9 C04E12.9 Protein containing two DUF40 domains of unknown function, which contain four conserved cysteines, has strong similarity to uncharacterized C. elegans F35F10.9 C04E6.10 C04E6.10 Protein of unknown function, has high similarity to uncharacterized C. elegans C04E6.9 7TM chemoreceptor, srd family C04E6.11 C04E6.11 Protein of unknown function C04E6.12 C04E6.12 Protein containing a trypsin inhibitor-like cysteine rich domain C04E6.2 C04E6.2 Protein of unknown function, has high similarity to uncharacterized C. elegans F58D7.1 7TM chemoreceptor, srsx family C04E6.3 C04E6.3 Protein of unknown function C04E6.4 C04E6.4 Protein of unknown function C04E6.5 C04E6.5 Member of the ubiquitin carboxyl-terminal hydrolase family 2, contains a ubiquitin carboxyl-terminal hydrolases family 2 domain, has weak similarity to ubiquitin specific protease 12 (ubiquitin hydrolyzing enzyme 1, human USP12) C04E6.6 grd-9;C04E6.6 Protein of unknown function, has weak similarity to C. elegans GRD-6 C04E6.7 C04E6.7 Member of the haloacid dehalogenase or epoxide hydrolase family, has a region of low similarity to a region of cytoplasmic epoxide hydrolase (mouse Ephx2), which metabolizes xenobiotic molecules and may play a role in blood pressure regulation C04E6.8 C04E6.8 Protein of unknown function C04E6.9 C04E6.9 Member of the 7-transmembrane chemoreceptor family of G protein-coupled receptors (GPCR), has high similarity to uncharacterized C. elegans C04E6.10 7TM chemoreceptor, srd family C04E7.1 C04E7.1 Protein of unknown function C04E7.2 C04E7.2 Protein of unknown function, has low similarity to uncharacterized C. elegans K02F6.7 C04E7.3 C04E7.3 Protein of unknown function, has weak similarity to C. elegans SDC-2, a protein involved in sex determination C04F1.1 C04F1.1 Member of the domain of unknown function DUF13 family, has high similarity to uncharacterized C. elegans C03G6.6 C04F1.2 C04F1.2 Protein containing four NHL repeats, which are often associated with RING finger and B-box motifs, has low similarity to peptidylglycine alpha-amidating monooxygenase (mouse Pam), which is a bifunctional enzyme that alpha-amidates neuroendocrine peptide C04F1.3 lim-7;Celim-7;C04F1.3 Protein containing two LIM domains, which may mediate protein-protein interactions and a homeobox domain, which are found in transcription factors, has moderate similarity to ISL1 transcription factor (human ISL1), which is associated with type 2 diabetes homeobox protein C04F12.1 C04F12.1 Protein containing a piwi domain, has weak similarity to uncharacterized C. elegans F20D12.1 C04F12.10 C04F12.10 Member of the M48 peptidase family of zinc metalloproteases, has moderate similarity to farnesylated proteins converting enzyme 1 (human ZMPSTE24), which is a zinc metalloprotease involved in the C-terminal CAAX processing of farnesylated proteins Zinc-binding metalloprotease domain; fce-1 encodes an ortholog of 'farnesylated-proteins converting enzyme 1' (FACE-1), and thus probably enables post-translational processing of proteins (such as LET-60/RAS) carrying a C-terminal CaaX motif; FCE-1 protein probably accounts for the EDTA-sensitive, tosylphenylalanylchloromethane-insensitive component of CaaX-proteolytic activity in membrane extracts from C. elegans, and FCE-1 can cleave a farnesylated peptide in vitro; the S. cerevisiae homolog of FCE-1 (Ste24p) cleaves the precursor of yeast a-factor mating pheromone after its farnesylated cysteine residue, and transgenic FCE-1 rescues a mating defect of mutant yeast lacking both the Ste24p and the Rce1p CaaX-proteases. C04F12.2 C04F12.2 Protein of unknown function, has very strong similarity to uncharacterized C. elegans Y38H6C.6 transposase C04F12.3 ikb-1;C04F12.3 Protein containing six ankyrin (Ank) repeats and a death domain, which may mediate protein-protein interactions, has a region of low similarity to a region of B cell CLL lymphoma 3 (human BCL3), which regulates the transcriptional activity of NF-kappa B Ank repeat; ikb-1 encodes an ortholog of human BCL3 (OMIM:109560) that physically interacts with the checkpoint protein MRT-2; ikb-1(nr2019) and ikb-1(nr2027) mutants display no obvious phenotype other than shortened lifespan; mutation of BCL3 is frequently associated with recurring translocations found in the neoplastic cells of patients with chronic lymphocytic leukemia, and has been implicated in cell cycle control (perhaps via apoptosis). C04F12.4 C04F12.4 Protein with high similarity to ribosomal protein L14 (S. cerevisiae Rpl14ap), which binds RNA and is a structural ribosomal protein, member of the ribosomal L14e family, which are part of the large ribosomal subunit rpl-14 encodes a large ribosomal subunit L14 protein. C04F12.5 C04F12.5 Protein of unknown function that may be anchored to the membrane of a secretory vesicle or the Golgi apparatus C04F12.6 C04F12.6 Protein containing a DUF236 domain of unknown function, has strong similarity to uncharacterized C. elegans K07A1.5 C04F12.7 C04F12.7 Protein of unknown function, has very strong similarity to uncharacterized C. elegans F41H10.1 C04F12.8 C04F12.8 Protein containing a dual specificity phosphatase catalytic domain, has low similarity to a region of MAPK phosphatase-7 (human MKP-7), which is a cytoplasmic protein phosphatase that preferentially inactivates human MAPK8 and human MAPK14 Dual specificity phosphatase, catalytic domain C04F12.9 C04F12.9 Member of the RNase H family, which digest the RNA strand of an RNA-DNA duplex, has low similarity to a region of ribonuclease H1 (mouse Rnaseh1), which binds to double stranded RNA and DNA-RNA hybrids and degrades RNA from DNA-RNA hybrids This gene encodes a protein predicted by Eisenberg and coworkers, with 52% accuracy, to be mitochondrial. C04F2.1 C04F2.1 Member of the 7-transmembrane chemoreceptor family of G protein-coupled receptors (GPCR), has high similarity to uncharacterized C. elegans W03F9.6 7TM chemoreceptor, srh family C04F2.4 C04F2.4 Member of the 7-transmembrane chemoreceptor family of G protein-coupled receptors (GPCR), has low similarity to uncharacterized C. elegans F37B4.6 7TM chemoreceptor, srh family C04F5.1 sid-1;C04F5.1 Protein with strong similarity to C. elegans R04E5.6 gene product The sid-1 gene encodes a predicted transmembrane protein with conserved human (OMIM:606816) and mouse homologs of unknown function and is required cell autonomously for systemic RNA interference (RNAi); a SID-1::GFP fusion is enriched at the cell periphery of most nonneuronal cells from late embryogenesis through adulthood with highest levels detected in cells exposed to the environment. C04F5.2 C04F5.2 Protein of unknown function, has weak similarity to C. elegans T10G3.2 C04F5.3 C04F5.3 Protein of unknown function unc-46 encodes a novel protein with a single predicted transmembrane domain; UNC-46 and UNC-47, a novel transmembrane vesicular GABA transporter, are required in GABAergic neurons for all GABA neurotransmission, specifically for loading of GABA into synaptic vesicles, where UNC-46 is localized; UNC-46 localization requires UNC-47, which when overexpressed can rescue unc-46 mutant animals. C04F5.4 C04F5.4 Member of the C. elegans Sre G protein-coupled chemoreceptor family, which are putative chemosensory receptors, has high similarity to uncharacterized C. elegans C04F5.5 7TM chemoreceptor, srab family C04F5.5 C04F5.5 Member of the C. elegans Sre G protein-coupled chemoreceptor family, which are putative chemosensory receptors, has high similarity to uncharacterized C. elegans C04F5.4 7TM chemoreceptor, srab family C04F5.6 C04F5.6 Member of the C. elegans Sre G protein-coupled chemoreceptor family, which are putative chemosensory receptors, has high similarity to uncharacterized C. elegans C04F5.4 7TM chemoreceptor, srab family C04F5.7 C04F5.7 Protein containing a UDP-glucoronosyl and UDP-glucosyl transferase domain, has weak similarity to bilirubin UDP-glucuronosyltransferase (rat UDPGT), which is a putative UDP-glucuronosyltransferase involved in bilirubin conjugation UDP-glucosyltransferase C04F5.8 C04F5.8 Protein of unknown function C04F5.9 C04F5.9 Protein containing six C2H2 type zinc finger domains, which bind nucleic acids, has a region of low similarity to a region of C. elegans SDC-1, which is involved in sex determination and dosage compensation C04F6.1 vit-5;C04F6.1 170 kDa yolk protein vit-5 encodes a vitellogenin, a lipid-binding protein precursor related to vertebrate vitellogenins and mammalian ApoB-100, a core LDL particle constituent; by homology, VIT-5 is predicted to function as a lipid transport protein; loss of vit-5 activity via large-scale RNA-mediated interference (RNAi) screens indicates that VIT-5 is required for embryogenesis and normal rates of postembryonic growth; VIT-5 is a major yolk component and is expressed exclusively in the adult hermaphrodite intestine from which it is secreted into the pseudocoelomic space and taken up by oocytes. C04F6.2 C04F6.2 Protein of unknown function C04F6.3 cht-1;CHT1;C04F6.3 Member of the glycosyl hydrolase 18 family, contains two chitin binding peritrophin-A domains, has moderate similarity to chitinase 1 (chitotriosidase, human CHIT1), which catalyzes the hydrolysis of chitin and is associated with Gaucher disease glycosyl hydrolase (family 18); cht-1 encodes a chitinase orthologous to human chitinase-1 (OMIM:600031, mutations are associated with chitotriosidase deficiency); CHT-1 is predicted to function as an extracellular O-glycosyl hydrolase that hydrolyzes the glycosidic bond between two or more carbohydrates; in C. elegans, CHT-1 may play a role in embryogenesis, and may also be required for cuticle degradation during molting and degradation of chitin-containing pathogens as part of a host defense mechanism. C04F6.4 unc-78;C04F6.4 Member of the WD repeat protein family; appears to be required for appropriate muscle structure beta transducin; The unc-78 gene encodes a homolog of actin-interacting protein 1 (AIP1) that regulates the ordered assembly of actin and cofilin in myofibrils. C04F6.5 C04F6.5 Member of the short-chain dehydrogenase-reductase family, which are NAD- or NADP-dependent oxidoreductases, contains a DUF 227 domain, has a region of moderate similarity to C. elegans DAZ-1, which is a meiotic factor required for oogenesis alcohol/ribitol dehydrogenase; dhs-27 encodes a short-chain dehydrogenase predicted to be mitochondrial. C04G2.1 C04G2.1 Member of the transthyretin-like family Transthyretin-like family C04G2.10 C04G2.10 Protein of unknown function, has a region of low similarity to a region of germ cell-specific gene 2 (haspin, mouse Gsg2), which is a serine-threonine kinase that binds DNA and may play roles in cell cycle cessation and haploid germ cell differentiation C04G2.11 C04G2.11 Protein containing a DUF41 domain of unknown function, has low similarity to uncharacterized C. elegans ZK355.5 C04G2.2 C04G2.2 Protein containing a protein kinase domain, has low similarity to a region of S. cerevisiae Hrr25p, which is a casein kinase I (serine/threonine/tyrosine protein kinase) involved in DNA repair and meiosis serine/threonine kinase C04G2.4 msp-36;C04G2.4 Member of the major sperm-specific protein (MSP) family major sperm protein; msp-36 encodes a protein that belongs to a family of proteins called the Major Sperm Proteins (MSPs) that is conserved in nematodes; this family comprises of closely related, small, basic proteins that make up 15% of sperm protein; this multigene family consists of over fifty genes, including many pseudogenes; MSP is involved in both extracellular signaling and cytoskeletal functions during reproduction-MSP antagonizes Eph/ephrin signaling, in part, by binding VAB-1 Eph receptor tyrosine kinase on oocytes and sheath cells to promote oocyte maturation and MAPK activation; MSP assembles into fibrous networks that drives movement of the C. elegans sperm; msp genes are expressed only in late primary spermatocytes. C04G2.5 C04G2.5 Protein with strong similarity to C. elegans B0457.4 gene product C04G2.6 C04G2.6 Member of the RNB-like family, which may have exonuclease activity, has moderate similarity to S. pombe Dis3p, which is an essential protein required for anaphase A mitotic events S.pombe mitotic control protein like C04G2.7 egl-38;lin-50;C04G2.7 Homeodomain transcription factor involved in regulation of lin-3 in vulval cells and in hindgut development, has similarity to many human and D. melanogaster homeodomain transcription factors Human paired box protein like; The egl-38 gene encodes a Pax5 homolog. C04G2.8 C04G2.8 Protein of unknown function, has strong similarity to uncharacterized C. elegans C10G11.9 C04G2.9 C04G2.9 Protein of unknown function, has strong similarity to uncharacterized C. elegans Y69E1A.B C04G6.1 C04G6.1 Protein containing two protein kinase domains, has moderate similarity to a region of mitogen activated protein kinase 7 (big mitogen activated protein kinase, mouse Mapk7), which interacts with MEK5 and is involved in EGF receptor signaling Ser/Thr protein kinase; mpk-2 encodes a mitogen activated protein (MAP) kinase; by homology, MPK-2 is predicted to function as a serine/threonine kinase that acts downstream of a receptor tyrosine kinase in a cell signaling pathway; however, as loss of mpk-2 activity via large-scale RNAi screens does not produce any obvious abnormalities, the precise role of MPK-2 in C. elegans development and/or behavior is not yet known. C04G6.10 C04G6.10 Protein with weak similarity to C. elegans C27A2.5 gene product C04G6.11 C04G6.11 Protein of unknown function C04G6.2 C04G6.2 Protein with strong similarity to C. elegans F54D10.9 gene product C04G6.3 C04G6.3 Putative phospholipase D, predicted to hydrolyze phosphatidylcholine to form phosphatidic acid and choline phospholipase D C04G6.4 C04G6.4 Protein of unknown function salt-stress induced peptide C04G6.5 C04G6.5 Member of the uncharacterized protein family UPF0057, has high similarity to uncharacterized C. elegans F47B7.1 salt-stress induced peptide C04G6.6 C04G6.6 Protein of unknown function C04G6.7 C04G6.7 Protein of unknown function, has high similarity to uncharacterized C. elegans C27A2.5 C04H5.1 C04H5.1 Protein of unknown function, has moderate similarity to uncharacterized human HSPC152 C04H5.2 C04H5.2 Protein containing a C-type lectin domain, which mediate calcium-dependent carbohydrate recognition, has moderate similarity to uncharacterized C. elegans EEED8.11 C04H5.3 C04H5.3 Protein containing a receptor family ligand binding domain C04H5.4 C04H5.4;C04H5.4 Protein containing two protein kinase domains and two adenylate and guanylate cyclase catalytic domains, has moderate similarity to a region of natriuretic peptide receptor A (mouse Npr1), which is a membrane-bound guanylate cyclase C04H5.6 mog-4;C04H5.6 Member of the RNA helicase, DEAH-box protein family Helicases conserved C-terminal domain; The mog-4 gene encodes a DEAH helicase orthologous to the Drosophila CG10689 and the S. cerevisiae PRP2 proteins. C04H5.7 C04H5.7 Protein of unknown function C05A2.1 C05A2.1 Member of the protein phosphatase protein family serine/threonine protein phosphatase C05A9.1 C05A9.1 Member of the ABC transporter family, which are involved in translocation across biological membranes, contains two ABC transporter transmembrane domains, has moderate similarity to C. elegans C47A10.1, which is a probable membrane transporter p-glycoprotein; pgp-5 encodes a transmembrane protein that is a member of the P-glycoprotein subclass of the ATP-binding cassette (ABC) transporter superfamily; by homology, PGP-5 is predicted to function as an ATP-dependent efflux pump that protects C. elegans by exporting exogenous toxins; however, as loss of pgp-5 activity via large-scale RNAi screens does not result in any obvious abnormalities, the precise role of PGP-5 in C. elegans development and/or behavior is not yet known. C05A9.2 C05A9.2 Protein of unknown function C05A9.3 C05A9.3 Protein containing three ankyrin (Ank) repeats, which may mediate protein-protein interactions ankyrin like C05B10.1 lip-1;C05B10.1 Putative dual-specificity protein phosphatase, involved in vulva cell fate specification protein-tyrosine phosphatase C05B10.2 C05B10.2 Protein of unknown function C05B5.1 C05B5.1 Protein of unknown function C05B5.2 C05B5.2 Putative ortholog of C. elegans C33F10.1 gene product C05B5.3 C05B5.3 Protein with weak similarity to S. cerevisiae NUP57 (Nuclear pore protein (nucleoporin) of the GLFG family) The protein product of this gene is predicted to contain a glutamine/asparagine (Q/N)-rich ('prion') domain, by the algorithm of Michelitsch and Weissman (as of the WS77 release of WormBase, i.e., in wormpep77). C05B5.4 C05B5.4 Protein of unknown function, has moderate similarity to uncharacterized C. elegans R10E12.2 C05B5.5 C05B5.5 Protein containing two EB module domains, and an F-box domain, which serves as a link between a target protein and a ubiquitin-conjugating enzyme, has a region of low similarity to a region of tenascin C (hexabrachion, human TNC) EGF repeats; This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins. C05B5.6 C05B5.6 Protein containing a DUF38 domain of unknown function C05B5.7 rgs-1;C05B5.7 Member of the regulator of G protein signaling domain protein family; modulates resumption of egg-laying after starvation 1r20 protein (human); rgs-1 encodes a regulator of G protein signaling; by homology, RGS-1 is predicted to function as a GTPase-activating protein for heterotrimeric G-protein alpha-subunits, and in vitro RGS-1 can stimulate the GTPase activity of purified GOA-1; in vivo, rgs-1 appears to function redundantly with rgs-2 to regulate egg-laying behavior when animals are refed following starvation; rgs-1 is expressed in most or all neurons. C05C10.1 C05C10.1 Member of the histidine acid phosphatase family, which hydrolyze phosphate esters at low pH, has low similarity to lysosomal acid phosphatase (rat Acp2), which is a tartrate-inhibitable lysosomal enzyme acid phosphatase C05C10.2 C05C10.2 Protein of unknown function, has a region of low similarity to a region of C. elegans SMG-2, which is involved in nonsense-mediated mRNA decay, mRNA surveillance, and RNAi-mediated gene suppression NAM7 protein C05C10.3 C05C10.3 Protein with high similarity to succinyl CoA:3-oxoacid CoA transferase (human OXCT), which acts in the conversion of acetoacetate to CoA and in ketone body metabolism and is associated with ketoacidosis, contains two coenzyme A transferase domains 3-oxoacid CoA-transferase; C05C10.3 is orthologous to the human gene 3-OXOACID COA TRANSFERASE (also called succinyl-CoA:3-ketoacid CoA transferase; OXCT; OMIM:245050), which when mutated leads to episodic ketoacidosis. C05C10.4 C05C10.4 Member of the histidine acid phosphatase family, which hydrolyze phosphate esters at low pH, has low similarity to lysosomal acid phosphatase (rat Acp2), which is a tartrate-inhibitable lysosomal enzyme acid phosphatase C05C10.5 C05C10.5 Protein of unknown function C05C10.6 C05C10.6 Protein containing ten WD domains (WD-40 repeat), which may mediate protein-protein interactions, has low similarity to phospholipase A2 activating protein (human PLAA), which may regulate phospholipase A2 activity and production of eicosanoids phospholipase activating protein C05C12.1 C05C12.1 Protein containing two protein kinase domains, has low similarity to S. pombe Cki1p, which is a casein kinase I serine/threonine kinase C05C12.3 C05C12.3 Member of the ion transport family, which include calcium, sodium, and potassium channels, has moderate similarity to C. elegans GON-2, which is a TRP channel protein that may mediate signal transduction for gonadal growth gtl-1 encodes a TRPM subfamily member of the TRP channel family that affects the periodicity of the defecation cycle in combination with gon-2; expression includes the intestine. C05C12.4 C05C12.4 Protein of unknown function C05C12.5 C05C12.5 Protein of unknown function C05C12.6 C05C12.6 Protein with weak similarity to C. elegans C39D10.6 gene product C05C8.1 C05C8.1 Protein of unknown function C05C8.2 C05C8.2 Putative ortholog of S. cerevisiae Krr1p, an essential protein of unknown function C05C8.3 dao-1;C05C8.3 Member of the FKBP-type peptidyl-prolyl cis-trans isomerase family, has low similarity to a region of FK506 binding protein 9 (mouse Fkbp9), which binds calcium and whose peptidyl prolyl isomerase activity is inhibited by binding to FK506 FKBP-binding protein; fkb-3 encodes a peptidylprolyl cis/trans isomerase homologous to mammalian FK506 immunosuppressant-binding protein 9; FKB-3 expression is positively regulated by signaling through the DAF-2 insulin receptor-like pathway and the activity of the DAF-16 fork-head transcription factor suggesting that FKB-3 could play a role in metabolism and longevity; however, as loss of FKB-3 function via RNA-mediated interference (RNAi) does not result in any abnormalities, the precise role of FKB-3 in C. elegans development and/or behavior is not yet known; FKB-3 contains a predicted endoplasmic reticulum (ER) retention sequence and is thus proposed to localize to the ER. C05C8.4 C05C8.4 Protein of unknown function, has weak similarity to human Hs.198760 and Hs.75735 heavy neurofilament subunit C05C8.5 C05C8.5 Member of the exonuclease family, has a region of low similarity to a region of ribonuclease H (S. cerevisiae RNH70), which is a 70 kDa endonuclease that degrades RNA in RNA-DNA hybrids C05C8.6 C05C8.6 Protein containing a BTB (BR-C, ttk and babor) or POZ (Pox virus and zinc finger) domain, which are found in some DNA and actin binding proteins, has a region of low similarity to a region of kelch-like 2 (Mayven, human KLHL2) C05C8.7 C05C8.7 Member of the phosphomannose isomerase type I family, has moderate similarity to phosphomannose isomerase (human MPI), which supplies D-mannose derivatives for glycosylation reactions and is associated with congenital disorders of glycosylation type Ib mannose-6-phosphate isomerase C05C8.8 C05C8.8 Protein containing a DUF138 domain of unknown function, has high similarity to uncharacterized C. elegans T06A1.1 C05C8.9 C05C8.9 Protein of unknown function C05C9.1 C05C9.1 Protein containing lipopolysaccharide-binding protein, bactericidal permeability-increasing protein or cholesteryl ester transfer protein N-terminal and C-terminal domains, has weak similarity to lipopolysaccharide-binding protein (mouse Lbp) LBP / BPI / CETP family C05C9.2 C05C9.2 Protein of unknown function C05C9.3 C05C9.3 Protein of unknown function NUM-1 like protein; The protein product of this gene is predicted to contain a glutamine/asparagine (Q/N)-rich ('prion') domain, by the algorithm of Michelitsch and Weissman (as of the WS77 release of WormBase, i.e., in wormpep77). C05D10.1 C05D10.1 Protein of unknown function C05D10.2 C05D10.2 Protein with high similarity to extracellular signal-regulated kinase 7 (rat ERK7), which is a protein serine-threonine kinase that inhibits cell proliferation and may regulate intracellular chloride channels, contains a protein kinase domain C05D10.3 C05D10.3 Member of the ABC transporter family, which are involved in translocation across biological membranes, has low similarity to ATP-binding cassette subfamily G member 1 (mouse Abcg1), which is an ABC transporter involved in cellular sterol homeostasis C05D10.4 C05D10.4 Protein containing two SAM (sterile alpha motif) domains, which may mediate protein-protein interactions C05D11.1 C05D11.1 Member of the insulinase (proteinase M16) protein family C05D11.10 MRPS17;C05D11.10 Possible ribosomal small subunit protein of the mitochondrion C05D11.11 mel-32;C05D11.11 Putative serine hydroxymethyltransferase C05D11.12 let-721;C05D11.12 Protein with high similarity to electron-transferring-flavoprotein dehydrogenase (human ETFDH), which is an electron acceptor for the mitochondrial matrix electron-transfer flavoprotein and reduces ubiquinone in the mitochondrial membrane YAAS; The let-721 gene encodes an ortholog of the human gene SIMILAR TO ELECTRON-TRANSFERRING-FLAVOPROTEIN DEHYDROGENASE (ETFDH), which when mutated leads to glutaricaciduria type IIC (OMIM:231675). C05D11.13 C05D11.13 Putative coiled-coil protein, has weak similarity to human trichohyalin ( Hs.82276), an intermediate filament-associated protein C05D11.2 C05D11.2 Protein of unknown function, has a region of weak similarity to a region of S. cerevisiae Vps16p, which is a vacuolar sorting protein C05D11.3 C05D11.3 Protein of unknown function, has moderate similarity to uncharacterized human APACD C05D11.4 let-756;ceFGF;C05D11.4 Member of the fibroblast growth factor protein family, has a region of moderate similarity to a region of fibroblast growth factor 9 (mouse Fgf9), which is a secreted growth-promoting factor heparin-binding gf; let-756 encodes an fibroblast growth factor (FGF)-like ligand that is required for progression through early larval development; LET-756 is expressed from late embryogenesis to adulthood, with a peak of expression in larvae; with EGL-17, LET-756 is redundantly required to activate EGL-15/FGFR, which in turn activates protein degradation in adult muscle cells; homozygotes for partial loss-of-function alleles are small, clear, and scrawny, but viable, while those for a null allele arrest in early larval development. C05D11.5 C05D11.5 Protein with strong similarity to D. melanogaster GIP glyoxylate-induced protein C05D11.6 C05D11.6 Member of the astacin (M12A) family of metalloproteases, has a region of moderate similarity to a region of the beta subunit of meprin A (rat Mep1b), which is an integral membrane protein that may play a role in embryogenesis zinc metalloprotease; nas-4 encodes a predicted extracellular matrix metalloprotease of the M12A (astacin) family that contains an N-terminal signal sequence and a catalytic domain, but no recognizable regulatory domains in the C-terminus; as loss of nas-4 activity via RNAi results in no obvious abnormalities, the precise role of NAS-4 in C. elegans development and/or behavior is not yet known; however, an NAS-4 translational reporter is expressed in the pharynx and intestine in larvae and adults, suggesting a role for NAS-4 in digestion; NAS-4 is specifically detected within cells of the pharyngeal procorpus, metacorpus, isthmus, and terminal bulb, with extracellular expression detected in the lumen of the terminal bulb and in the gut. C05D11.7 C05D11.7 Protein with strong similarity to C. elegans D1054.1 gene product C05D11.8 C05D11.8 Protein of unknown function C05D11.9 C05D11.9 Protein of unknown function C05D12.1 C05D12.1 Protein with moderate similarity to C. elegans dao-2 gene product C05D12.2 C05D12.2 Protein of unknown function, has high similarity to uncharacterized C. elegans Y19D10B.4 EGF domains C05D12.4 C05D12.4 Putative coiled-coil protein, has weak similarity to myosin heavy chains C05D12.5 C05D12.5 Putative coiled-coil protein, has weak similarity to S. cerevisiae Uso1p C05D2.1 daf-4;C05D2.1 Tpe II receptor kinase; involved in regulation of dauer formation, body size, and male tail development daf-4 encodes a transmembrane serine/threonine kinase that is the sole C. elegans ortholog of the type II transforming growth factor-beta (TGF-b) receptors; DAF-4 activity is required for several biological processes, including entry into and exit from the dauer larval stage, body size determination, male tail patterning, egg laying, chemosensory neuron specification, and increased thermotolerance; in regulating dauer larval development, DAF-4 acts in parallel with the insulin signaling pathway and likely partners with the DAF-1 type I TGF-b receptor to receive a signal from the DAF-7 TGF-b ligand; in body size determination and male tail patterning, DAF-4 likely partners with the SMA-6 type I receptor and responds to signals from the DBL-1 ligand; DAF-4 expression begins in late embryogenesis and continues through larval and adult stages; consistent with its role in many developmental processes, DAF-4 localizes to the plasma membrane of several tissues including head and tail neurons, the pharynx, intestine, ventral nerve cord, tail hypodermis, and body wall muscle. C05D2.10 C05D2.10 Protein with strong similarity to C. elegans lin-23 gene product C05D2.3 C05D2.3 Protein containing two pyridoxal-dependent group II decarboxylase conserved domains, which bind pyridoxal-phosphate groups, has moderate similarity to dopa decarboxylase (aromatic L-amino acid decarboxylase, rat Ddc) aromatic-L-amino-acid decarboxylase C05D2.4 C05D2.4 Protein containing two pyridoxal-dependent group II decarboxylase conserved domains, which bind pyridoxal-phosphate groups, has moderate similarity to dopa decarboxylase (aromatic L-amino acid decarboxylase, mouse Ddc) aromatic-L-amino-acid decarboxylase; bas-1 encodes a serotonin- and dopamine-synthetic aromatic amino acid decarboxylase (AAADC) that is required for the synthesis of serotonin from 5-hydroxytryptophan in vivo; mutations of bas-1 impair the turning step in male mating, the migration of AVM, SDQR, ALM, and BDU neurons during development. C05D2.5 C05D2.5 Protein involved in germ cell development gak-1 encodes a protein that contains an AT hook motif, a DNA-binding domain that shows a preference for binding stretches of A/T base pairs; GAK-1 appears to play a role in meiotic chromosome segregation, as overexpression results in post-prophase I chromosome segregation abnormalities, and a corresponding increase in embryonic lethality and the proportion of genotypically XO males in an otherwise self-fertile, XX hermaphrodite population; loss of gak-1 function via RNA-mediated interference (RNAi) results in sterility in the injected hermaphrodites, suggesting a possible role in germline development as well; gak-1 expression is enhanced in the germline, although its precise subcellular localization has not been reported. C05D2.6 C05D2.6 Member of the WD repeat protein family C05D2.6 encodes an unfamiliar protein, with no known non-nematode homologs, that specifically binds GOA-1 in yeast two-hybrid assays; C05D2.6 is expressed in several head and tail neurons, pharyngeal muscle, intestine, distal tip cell of the gonad, with weak expression in the ventral nerve cord; C05D2.6 is required for fertility in RNAi assays, with a phenotype of either sterile progeny or reduced brood size for C05D2.6(RNAi) in an rrf-3 mutant background. C05D2.8 C05D2.8 Putative ortholog of C. elegans C05D2.7 gene product C05D9.1 SNX1;C05D9.1 Protein containing a phox protein (PX) domain, which bind phosphoinositides, has moderate similarity to sorting nexin 1 (human SNX1), which may function in intracellular trafficking of receptors to various organelles, including endosomes and lysosomes C05D9.2 C05D9.2 Protein of unknown function, has weak similarity to human LAMP2 (lysosomal-associated membrane protein 2) C05D9.3 C05D9.3 Protein with moderate similarity integrin cell-surface receptors that may be anchored to the membrane of a secretory vesicle or the Golgi apparatus C05D9.4 C05D9.4 Protein of unknown function C05D9.5 ife-4;C05D9.5 Putative translation initiation factor eIF4E, binds to the mRNA cap structure initiation factor 4E (EIF-4E); The ife-4 gene encodes a member of the Initiation Factor 4E (eIF4E) family. C05D9.7 C05D9.7 Protein of unknown function C05D9.8 C05D9.8 Protein containing a von Willebrand factor (vWF) type A domain C05D9.9 C05D9.9 Protein of unknown function C05E11.1 C05E11.1 Protein of unknown function C05E11.2 C05E11.2 Protein of unknown function C05E11.3 C05E11.3 Protein of unknown function, has weak similarity to C. elegans F56C11.5 C05E11.4 C05E11.4 Member of the ammonium transporter family of membrane transporters, has low similarity to S. cerevisiae Mep1p, which is an ammonia permease of high capacity and moderate affinity ammonium transporter; amt-1 encodes a transmembrane transporter that by homology, is predicted to transport ammonium ions across the plasma membrane; as loss of amt-1 activity via large-scale RNAi screens does not result in any obvious abnormalities, the precise role of AMT-1 in C. elegans development and/or behavior is not yet known. C05E11.5 C05E11.5 Member of the ammonium transporter family of membrane transporters, has low similarity to S. cerevisiae Mep3p, which is an ammonia permease of high capacity and low affinity ammonium transporter; amt-4 encodes a member of the ammonium transporter protein family. C05E11.6 C05E11.6 Protein of unknown function C05E11.7 C05E11.7 Protein of unknown function, has moderate similarity to C. elegans T14E8.3 C05E11.8 flp-12;C05E11.8 Putative FMRF-amide neurotransmitter flp-12 encodes a predicted FMRFamide-like peptide neurotransmitter that affects locomotion when injected into A. suum; expressed in the ASE and PVM sensory neurons. C05E4.1 C05E4.1 Member of the serpin family of serine protease inhibitors, has low similarity to serine proteinase inhibitor class I member 1 (neuroserpin, mouse Serpini1), which inhibits plasmin, plasminogen activator, urokinase and may function in synaptic plasticity serine protease inhibitor; srp-2 encodes an ovalbumin-like serpin (ov-serpin) member of the serine protease inhibitor superfamily that is orthologous to human NEUROSERPIN (OMIM:602445, mutated in familial encephalopathy with neuroserpin inclusion bodies); SRP-2 is predicted to function as a suicide substrate that inhibits the proteolytic activity of serine proteases, and in vitro, recombinant SRP-2 is able to inhibit granzyme B activity; however, as loss of srp-2 function via RNA-mediated interference (RNAi) does not result in any obvious abnormalities, the precise role of SRP-2 in C. elegans development and/or behavior is not yet known; srp-2 expression is detected in hypodermal cells, particularly in the lateral seam cells. C05E4.10 C05E4.10 Member of the 7-transmembrane chemoreceptor family of G protein-coupled receptors (GPCR), has strong similarity to uncharacterized C. elegans C05E4.11 7TM chemoreceptor, srj family C05E4.11 C05E4.11 Member of the 7-transmembrane chemoreceptor family of G protein-coupled receptors (GPCR), has strong similarity to uncharacterized C. elegans C05E4.10 7TM chemoreceptor, srj family C05E4.12 C05E4.12 Protein of unknown function, has a region of low similarity to a region of C. elegans PHA-1, which is involved in pharyngeal development C05E4.13 C05E4.13 Member of the 7-transmembrane chemoreceptor family of G protein-coupled receptors (GPCR), has weak similarity to C. elegans ODR-10, which is a G protein-coupled receptor involved in odorant response 7TM chemoreceptor, str family C05E4.14 C05E4.14 Protein of unknown function, has strong similarity to C. elegans K09D9.7 7TM chemoreceptor, srh family C05E4.2 C05E4.2 Member of the 7-transmembrane chemoreceptor family of G protein-coupled receptors (GPCR), has low similarity to C. elegans ODR-10, which is a G protein-coupled receptor involved in odorant response 7TM chemoreceptor, str family C05E4.3 C05E4.3 Member of the serpin family of serine protease inhibitors, has low similarity to squamous cell carcinoma antigen 2 (mouse Scca2), which inhibits chymotrypsin-like serine proteases serine protease inhibitor; srp-1 encodes an ovalbumin-like serpin (ov-serpin) member of the serine protease inhibitor superfamily; by homology, SRP-1 is predicted to function as a suicide substrate that inhibits the proteolytic activity of serine proteases; however, as loss of srp-1 function via RNA-mediated interference (RNAi) does not result in any obvious abnormalities, the precise role of SRP-1 in C. elegans development and/or behavior is not yet known. C05E4.4 C05E4.4 Protein of unknown function, has low similarity to uncharacterized C. elegans F15H9.2 7TM chemoreceptor, sri family C05E4.6 C05E4.6 Member of the 7-transmembrane chemoreceptor family of G protein-coupled receptors (GPCR), has low similarity to C. elegans ODR-10, which is a G protein-coupled receptor involved in odorant response 7TM chemoreceptor, str family C05E4.7 C05E4.7 Protein of unknown function C05E4.8 C05E4.8 Protein with high similarity to C. elegans C01B12.6, which is a transposase, member of the transposase family, which are required for excising and inserting mobile genetic elements, contains a retroviral integrase core domain transposase C05E4.9 C05E4.9 Putative ortholog of S. cerevisiae MLS1 gene product (Malate synthase 1, functions in glyoxylate cycle, has near identity to Dal7p) isocitrate lyase; gei-7 encodes a predicted isocitrate lyase/malate synthase, an enzyme known to function in the glyoxylate cycle; GEI-7 was identified in a screen for proteins that interact with GEX-3, a homolog of human HEM-2 which is required for embryonic development; GEI-7 is required for embryonic morphogenesis and appears to act downstream of DAF-16 to influence lifespan. C05E7.1 C05E7.1;C05E7.1 Protein of unknown function, has low similarity to uncharacterized C. elegans C05E7.2 C05E7.2 C05E7.2 Protein of unknown function, has low similarity to uncharacterized C. elegans C05E7.1 C05E7.3 C05E7.3 Protein of unknown function C05E7.4 C05E7.4 Protein of unknown function, has low similarity to uncharacterized C. elegans K07E8.5 C05E7.5 VF11C1L.1;C05E7.5 Protein with strong similarity to S. cerevisiae Fab1p, a phosphatidylinositol-3-phosphate 5-kinase involved in orientation or separation of mitotic chromosomes C05G5.1 C05G5.1 Member of an uncharacterized protein family C05G5.2 C05G5.2 Protein of unknown function, has weak similarity to C. elegans C50F2.2 C05G5.3 C05G5.3 Protein of unknown function C05G5.4 C05G5.4 Protein with high similarity to succinyl-CoA synthetase alpha subunit (rat Suclg1), which catalyzes formation of succinyl-CoA in the tricarboxylic acid cycle, member of the ATP-citrate lyase or succinyl-CoA ligase family, contains one CoA binding domain succinyl-CoA synthetase; This gene encodes a protein predicted by Eisenberg and coworkers, with 68% accuracy, to be mitochondrial. C05G5.5 C05G5.5 Protein of unknown function C05G6.1 C05G6.1 Protein containing a nuclear hormone receptor ligand-binding domain C05G6.2 nhr-76;C05G6.2 Protein containing a nuclear hormone receptor C4-type zinc finger domain, which bind DNA and may be involved in transcription regulation, has moderate similarity to a region of rat Nr3c1, which is a hormone-dependent transcription factor C05H8.1 CaM-KK;C05H8.1 Calcium and calmodulin-dependent protein kinase kinase" ckk-1 encodes a calcium and calmodulin-dependent protein kinase kinase family member that affects CRE-dependent transcription in neurons. C05H8.2 C05H8.2 Protein of unknown function C06A1.1 C06A1.1 Member of the ATPases associated with various cellular activities (AAA) family transitional endoplasmic reticulum ATPase homolog 1 (P97 protein) C06A1.2 C06A1.2 Protein of unknown function C06A1.3 C06A1.3 Member of the protein phosphatase protein family serine/threonine protein phosphatase C06A1.4 C06A1.4 Protein containing a piwi domain and a PAZ (Piwi, Argonaut and Zwille) domain, which may mediate protein-protein interactions, has strong similarity to uncharacterized C. elegans F58G1.1 C06A1.5 C06A1.5 Protein with high similarity to a shared subunit of RNA polymerases I, II, and III (ABC23, S. cerevisiae Rpo26p), member of the RNA polymerases K 14-18 Kd subunit family, which are shared among all three types of eukaryotic RNA polymerases DNA directed RNA polymerase C06A1.6 C06A1.6 Protein of unknown function C06A12.3 C06A12.3 Protein of unknown function, has moderate similarity to uncharacterized C. elegans Y43F8B.2 C06A12.4 gcy-27;C06A12.4 Protein containing two protein kinase domains and an adenylate and guanylate cyclase catalytic domain, has high similarity to a region of C. elegans GCY-10, which is a putative guanylyl cyclase expressed in neurons and involved in chemosensation guanylate cyclase (2 domains) C06A12.5 C06A12.5 Protein of unknown function, has moderate similarity to uncharacterized C. elegans ZK945.1 C06A5.1 C06A5.1 Protein of unknown function C06A5.10 C06A5.10 Protein with strong similarity to C. elegans Y76G2A.2 gene product C06A5.11 C06A5.11 Protein with moderate similarity to C. elegans sir-2.1 gene product C06A5.2 C06A5.2 Protein of unknown function C06A5.4 C06A5.4 Putative ortholog of C. elegans Tc8.1 gene product C06A5.6 C06A5.6 Protein of unknown function, has moderate similarity to uncharacterized C. elegans ZK856.12 C06A5.7 C06A5.7 Protein with moderate similarity to tropomodulin (human TMOD), which is a putative capping protein of the actin thin filament pointed end and integral component of the cytoskeletal lattice that regulates cell adhesion and may regulate thin filament length tropomodulin; tmd-1 encodes a predicted member of the tropomodulin family and affects egg laying, locomotion, and muscle organization in one analysis using RNAi. C06A5.8 C06A5.8 Protein containing a C3HC4 type RING zinc finger, which may mediate protein-protein interactions C06A5.9 C06A5.9 Protein containing a C3HC4 type RING zinc finger, which may mediate protein-protein interactions C06A6.1 C06A6.1 Protein of unknown function C06A6.2 C06A6.2 Protein of unknown function C06A6.3 C06A6.3 Protein of unknown function C06A6.4 C06A6.4 Member of the M20, M25, or M40 peptidase family of zinc metalloproteases, has moderate similarity to aminoacylase 1 (human ACY1), which catalyzes the hydrolysis of N-alpha-acylated amino acids and may contribute to small cell lung cancer development aminoacylase-1 C06A6.5 C06A6.5 Member of the thioredoxin family, has weak similarity to a region of intestinal calcium binding protein (mouse Cai), which is an endoplasmic reticulum protein that has cysteine-type peptidase activity C06A8.1 C06A8.1 Member of the methylenetetrahydrofolate reductase family, which may be associated with hyperhomocysteinemia, has moderate similarity to 5',10'-methylenetetrahydrofolate reductase (human MTHFR), which catalyzes the conversion of methylenetetrahydrofolate C06A8.1 is orthologous to human MSH HOMEO BOX HOMOLOG 1 (MTHFR; OMIM:142983, mutated in homocystinuria). C06A8.2 C06A8.2 Protein of unknown function, has low similarity to uncharacterized C. elegans Y39E4B.2 C06A8.3 C06A8.3 Protein containing a DUF148 domain of unknown function, has high similarity to uncharacterized C. elegans ZK970.7 17k antigen (O. volvulus) C06A8.4 skr-17;C06A8.4 Protein with similarity to D. melanogaster skpA, a protein containing an ATP/GTP-binding site motif A skr-17 encodes a homolog of Skp1 in S. cerevisiae, a core component of the SCF (Skp1p, Cullin, F-box) ubiquitin-ligase complex that facilitates ubiquitin-mediated protein degradation; SKR-17 has no known function in vivo, since skr-17(RNAi) animals are at least superficially normal, and SKR-17 does not appear to interact in vitro with any of the C. elegans cullin homologs. C06A8.5 C06A8.5 Protein with weak similarity to myosin heavy chains of human, D. melanogaster and S. cerevisiae C06A8.6 C06A8.6 Protein containing seven leucine rich repeats, which mediate protein-protein interactions, has moderate similarity to S. pombe Sds22p, which is a protein phosphatase PP1 regulatory subunit required for chromosome disjunction during mitosis C06A8.7 C06A8.7 Member of the 7-transmembrane chemoreceptor family of G protein-coupled receptors (GPCR), has low similarity to uncharacterized C. elegans W02H5.6 7TM chemoreceptor, srh family C06A8.8 C06A8.8 Protein of unknown function C06A8.9 glr-4;C06A8.9 Protein containing a ligand-gated ion channel domain, has low similarity to glutamate receptor ionotropic kainate-selective 2 (human GRIK2), which is a ligand-gated ion channel subunit that plays a role in excitatory neurotransmission Glutamate receptor C06B3.1 C06B3.1 Member of the 7-transmembrane chemoreceptor family of G protein-coupled receptors (GPCR), has high similarity to uncharacterized C. elegans K02H11.3 G-protein coupled receptor C06B3.10 C06B3.10 Member of the 7-transmembrane chemoreceptor family of G protein-coupled receptors (GPCR), has low similarity to C. elegans ODR-10, which is a G protein-coupled receptor involved in odorant response C06B3.11 C06B3.11 Protein with strong similarity to C. elegans T10C6.3 gene product C06B3.2 C06B3.2 Member of the uncharacterized protein family UPF0063, has high similarity to uncharacterized C. elegans F36G9.12 C06B3.3 C06B3.3 Member of the cytochrome P450 family, has low similarity to cytochrome P450 2j4 (rat Cyp2j4), which is a monooxygenase that converts arachidonic acid to hydroxyeicosatetraenoic and epoxyeicosatrienoic acids cytochrome P450 C06B3.4 C06B3.4 Member of the short-chain dehydrogenase-reductase family, which are oxidoreductases, has moderate similarity to hydroxysteroid 17-beta dehydrogenase type 3 (human HSD17B3), which preferentially converts androstenedione to testosterone in the testis estradiol 17 beta-dehydrogenase; This gene encodes a protein predicted by Eisenberg and coworkers, with 68% accuracy, to be mitochondrial. C06B3.5 C06B3.5 Member of the short-chain dehydrogenase-reductase family, which are NAD- or NADP-dependent oxidoreductases, has moderate similarity to hydroxysteroid 17-beta dehydrogenase type III (rat Rn.10895), which converts androstenedione to testosterone estradiol 17 beta-dehydrogenase; This gene encodes a protein predicted by Eisenberg and coworkers, with 68% accuracy, to be mitochondrial. C06B3.6 C06B3.6 Protein of unknown function, has high similarity to uncharacterized C. elegans F13A7.11 C06B3.7 C06B3.7 Protein of unknown function, has low similarity to uncharacterized C. elegans F17C11.11 C06B3.8 gcy-32;C06B3.8 Putative soluble guanylyl cyclase guanylate cyclase; gcy-32 encodes a predicted guanylate cyclase; expressed in URX, AQR, and PQR neurons. C06B3.9 C06B3.9 Member of the 7-transmembrane chemoreceptor family of G protein-coupled receptors (GPCR), has high similarity to uncharacterized C. elegans C06B3.10 C06B8.1 C06B8.1 Protein containing a nuclear hormone receptor ligand-binding domain, has weak similarity to hepatocyte nuclear factor 4 gamma (human HNF4G), which is involved in differential transcriptional regulation of HNF4-dependent genes zinc finger protein C06B8.2 C06B8.2 Protein containing two DUF235 domains of unknown function, has high similarity to uncharacterized C. elegans Y45G12C.1 C06B8.3 C06B8.3 Putative ortholog of C. elegans F26D2.15 gene product dehydrogenase; This gene encodes a protein predicted by Eisenberg and coworkers, with 68% accuracy, to be mitochondrial. C06B8.4 C06B8.4 Member of the 7-transmembrane chemoreceptor family of G protein-coupled receptors (GPCR), has low similarity to C. elegans ODR-10, which is a G protein-coupled receptor involved in odorant response 7tm receptor C06B8.5 C06B8.5 Member of the transposase family, which are required for excising and inserting mobile genetic elements, has very strong similarity to uncharacterized C. elegans C31A11.2 transposase C06B8.6 C06B8.6 Member of the 7-transmembrane chemoreceptor family of G protein-coupled receptors (GPCR), has low similarity to uncharacterized C. elegans T22F3.5 C06B8.7 C06B8.7 Protein containing three scavenger receptor cysteine rich domain, which may mediate protein-protein interactions Human M130 antigen like protein C06B8.8 C06B8.8 Protein with high similarity to ribosomal protein L38 (S. cerevisiae Rpl38p), which is a structural ribosomal protein, member of the ribosomal L38e family, which are part of the large ribosomal subunit rpl-38 encodes a large ribosomal subunit L38 protein. C06C3.1 mel-11;C06C3.1 Myosin phosphatase regulatory subunit required for embryonic elongation ankyrin-like repeats C06C3.3 C06C3.3 Protein with weak similarity to C. elegans UNC-89 C06C3.4 C06C3.4 Putative ortholog of C. elegans C06C3.9 gene product C06C3.5 C06C3.5 Protein with moderate similarity to C. elegans C06C3.8 gene product C06C3.6 C06C3.6 Member of the 7-transmembrane chemoreceptor family of G protein-coupled receptors (GPCR), has moderate similarity to uncharacterized C. elegans C10G11.4 C06C3.7 C06C3.7 Protein of unknown function, has weak similarity to S. cerevisiae Ynl136p C06C3.8 C06C3.8 Putative ortholog of C. elegans B0454.9 gene product This gene encodes a protein predicted by Eisenberg and coworkers, with 68% accuracy, to be mitochondrial. C06C3.9 C06C3.9 Protein containing a DUF38 domain of unknown function and an F-box domain, which links a target protein to ubiquitin-conjugating enzyme, has a region of low similarity to a region of C. elegans FOG-2, which is needed for the sexual identity of germ cells C06C6.1 C06C6.1 Member of the 7-transmembrane chemoreceptor family of G protein-coupled receptors (GPCR), has high similarity to uncharacterized C. elegans T10C6.2 7TM receptor C06C6.2 C06C6.2 Member of the 7-transmembrane chemoreceptor family of G protein-coupled receptors (GPCR), has weak similarity to C. elegans ODR-10, which is a G protein-coupled receptor involved in odorant response 7TM receptor C06C6.3 C06C6.3 Member of the 7-transmembrane chemoreceptor family of G protein-coupled receptors (GPCR), has weak similarity to C. elegans ODR-10, which is a G protein-coupled receptor involved in odorant response 7TM receptor C06C6.4 nhr-63;C06C6.4 Member of the nuclear hormone receptor/Zinc finger protein family Zinc finger, C4 type (two domains) C06C6.5 nhr-50;C06C6.5 Member of the nuclear hormone receptor/Zinc finger protein family Zinc finger, C4 type (two domains) C06C6.6 C06C6.6 Protein containing a WSN domain of unknown function, has high similarity to uncharacterized C. elegans Y57G7A.6 C06C6.7 C06C6.7 Protein containing a WSN domain of unknown function, has high similarity to uncharacterized C. elegans C06C6.6 C06C6.8 C06C6.8 Protein of unknown function, has strong similarity to uncharacterized C. elegans C06C6.9 C06C6.9 C06C6.9 Protein of unknown function, has strong similarity to uncharacterized C. elegans C06C6.8 C06E1.1 C06E1.1 Small protein of unknown function, has similarity to S. cerevisiae Yip2p, has weak similarity to human polyposis locus protein, TB2 C06E1.10 C06E1.10 Member of the RNA helicase, DEAH-box protein family ATP-dependent RNA helicase; The C06E1.10 gene encodes a DEAH helicase orthologous to the Drosophila KURZ, the human KIAA1517, and the S. cerevisiae ECM16 proteins. C06E1.11 C06E1.11 Protein with strong similarity to C. elegans C13G5.2 gene product C06E1.2 C06E1.2 Protein of unknown function, has weak similarity to C. elegans C06E1.5 C06E1.3 C06E1.3 Protein of unknown function C06E1.4 glr-1;not-3;C06E1.4 Alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA)-type glutamate receptor (GluR); a putative ligand-gated ion channel in post-synaptic structures of the ventral nerve chord and the nerve ring Glutamate receptor subunit; glr-1 encodes an AMPA (non-NMDA)-type ionotropic glutamate receptor subunit; GLR-1 activity is required for mediating the behavioral response to light nose touch and the frequency with which animals change locomotory direction in response to sensory cues such as food; GLR-1 and GLR-2, a second AMPA-type ionotropic glutatmate receptor, can interact to form functional heteromeric channels; GLR-1 is expressed in motorneurons and interneurons, including four of the five pairs of command interneurons that are required for locomotory control; in the ventral nerve cord and nerve ring, GLR-1 localizes to perinuclear structures in cell bodies and to punctate structures that appear to be glutamatergic postsynaptic specializations; proper GLR-1 localization in the anterior ventral nerve cord of older larvae and adults requires activity of the class I PDZ protein LIN-10; GLR-1 is ubiquitinated in vivo and its abundance at postsynaptic elements, which may influence postsynaptic strength, is regulated by ubiquitination. C06E1.5 C06E1.5 Protein of unknown function, has weak similarity to C. elegans C06E1.2 C06E1.6 C06E1.6 Protein of unknown function, has weak similarity to C. elegans C06E1.2 C06E1.7 C06E1.7 Member of the glycosyl transferase family 11, which hydrolyze the glycosidic bond between two or more carbohydrates, has moderate similarity to uncharacterized C. elegans C14C6.3 C06E1.8 C06E1.8 Protein containing three C2H2 type zinc finger domains, which bind nucleic acids, has low similarity to C. elegans HAM-2, which is a putative transcription factor required for migration of hermaphrodite-specific neurons C06E1.9 C06E1.9 Protein of unknown function C06E2.1 C06E2.1 Protein of unknown function C06E2.2 C06E2.2 Protein of unknown function C06E2.3 C06E2.3 Protein with high similarity to huntingtin interacting protein 2 (human HIP2), which is a ubiquitin-conjugating enzyme that interacts with huntingtin (HD) in the brain, member of the ubiquitin-conjugating enzyme (E2) family ubiquitin-conjugating enzyme C06E2.5 C06E2.5 Protein of unknown function C06E2.7 C06E2.7 Protein containing a UBA (ubiquitin associated) or TS-N domain, has low similarity to uncharacterized C. elegans F40G9.3 ubc-22 encodes an E2 ubiquitin-conjugating enzyme orthologous to Saccharomyces cerevisiae UBC8 and human UBC1/HIP2 (Huntingtin interacting protein 2, OMIM:602846) which are involved in regulating fructose-1,6-bisphosphatase and huntingtin catabolism, respectively; by homology, UBC-22 is likely required for covalent attachment of ubiquitin to select target proteins to facilitate their degradation; however, as loss of UBC-22 activity via RNA-mediated interference (RNAi) does not result in any abnormalities, the precise role of UBC-22 in C. elegans development and/or behavior is not yet known. C06E4.1 C06E4.1 Protein with strong similarity to C. elegans C43E11.5 gene product C06E4.2 C06E4.2 Protein of unknown function C06E4.3 C06E4.3 Member of the short-chain dehydrogenase-reductase family, which are NAD- or NADP-dependent oxidoreductases, has low similarity to peroxisomal trans 2-enoyl CoA reductase (human HSA250303), which catalyzes the reduction of trans 2-enoyl CoAs dehydrogenase; This gene encodes a protein predicted by Eisenberg and coworkers, with 68% accuracy, to be mitochondrial. C06E4.4 C06E4.4 Protein of unknown function, has high similarity to uncharacterized C. elegans C06E4.3 dehydrogenase; This gene encodes a protein predicted by Eisenberg and coworkers, with 68% accuracy, to be mitochondrial. C06E4.5 C06E4.5 Protein with moderate similarity to C. elegans Y48B6A.10 gene product C06E4.6 C06E4.6 Member of the alcohol/ribitol dehydrogenase-like protein family dehydrogenase; This gene encodes a protein predicted by Eisenberg and coworkers, with 68% accuracy, to be mitochondrial. C06E4.7 C06E4.7 Protein of unknown function C06E4.8 C06E4.8 Protein of unknown function C06E7.1 C06E7.1 Protein with high similarity to C. elegans C49F5.1, contains two S-adenosylmethionine synthetase N-terminal domains, an S-adenosylmethionine synthetase central domain, and an S-adenosylmethionine synthetase C-terminal domain S-adenosylmethionine synthetase C06E7.2 C06E7.2 Protein of unknown function C06E7.3 C06E7.3 Protein with high similarity to C. elegans C49F5.1, contains an S-adenosylmethionine synthetase N-terminal domain, an S-adenosylmethionine synthetase C-terminal domain, and an S-adenosylmethionine synthetase central domain S-adenosylmethionine synthetase C06E7.4 C06E7.4 Putative ortholog of C. elegans C06E7.5 gene product C06E7.5 C06E7.5 Putative ortholog of C. elegans C06E7.4 gene product C06E7.6 spe-27;C06E7.6 Protein required for spermatogenesis Uncloned locus required for sperm activation (morphogenesis of sperm to crawling spermatozoa), and may act in a common signaling pathway with spe-12 and spe-29 to initiate sperm activation, based on genetic analysis. C06E7.7 C06E7.7 Protein of unknown function, has low similarity to uncharacterized C. elegans Y73B6BL.10 7TM chemoreceptor, srv family C06E8.1 C06E8.1 Protein of unknown function C06E8.3 prk-1;C06E8.3 Protein containing two protein kinase domains, has a region of moderate similarity to proviral integration site 3 (kinase induced by depolarization 1) (rat Pim3), which is a serine-threonine protein kinase that may play a role in neurogenesis Protein kinase C06E8.4 C06E8.4 Member of the reverse transcriptase protein family, which are RNA-dependent DNA polymerases, has very strong similarity to uncharacterized C. elegans F28E10.3 C06E8.5 C06E8.5 Protein containing a lipopolysaccharide-binding protein, bactericidal permeability-increasing protein or cholesteryl ester transfer protein C-terminal domain, has weak similarity to uncharacterized C. elegans C55C3.1 bacterial permeability-increasing protein C06G1.1 C06G1.1 Protein containing a lipopolysaccharide-binding protein, bactericidal permeability-increasing protein or cholesteryl ester transfer protein C-terminal domain C06G1.2 C06G1.2 Protein of unknown function, has weak similarity to C. elegans F35C5.3 C06G1.4 C06G1.4 Protein of unknown function, has low similarity to uncharacterized C. elegans B0041.2 C06G1.5 C06G1.5 Protein of unknown function, has a region of moderate similarity to protein phosphatase 2 (PP2A) regulatory subunit B (mouse Ppp2r3), which cooperates in dephosphorylation of retinoblastoma protein (Rb1)-related p107 leading to cell cycle arrest protein phosphatase PP2A C06G3.1 C06G3.1 Protein containing a nuclear hormone receptor ligand-binding domain, which bind DNA and may regulate transcription, and a nuclear hormone receptor C4-type zinc finger domain, has weak similarity to hepatocyte nuclear factor 4 alpha (human HNF4A) zinc finger protein C06G3.10 CeLDLC;C06G3.10 Protein with moderate similarity to H. sapiens LDLC, which is a protein required for normal Golgi function C06G3.11 C06G3.11 Protein containing a Tim10 or DDP family zinc finger domain, has moderate similarity to S. cerevisiae Tim9p, which is an essential component of the mitochondrial import machinery and required for transfer of hydrophobic inner membrane carrier proteins tin-9 encodes a member of the Tim10/DDP family of zinc finger proteins, a family of proteins typically involved in mitochondrial protein import, and localized to the mitochondrial intermembrane space. C06G3.12 C06G3.12 Protein with strong similarity to C. elegans F54H12.3 gene product C06G3.2 klp-18;C06G3.2 Protein containing a kinesin motor domain, which binds ATP and microtubules, has low similarity to kinesin heavy chain (human KIF5B), which is a microtubule-associated motor protein that may function in intracellular organelle transport kinesin-like protein C06G3.3 C06G3.3 Protein of unknown function C06G3.4 C06G3.4 Protein of unknown function, has high similarity to uncharacterized C. elegans F56D5.9 C06G3.5 C06G3.5 Member of the adenosine and AMP deaminase family, which catalyze hydrolytic deamination of adenosine, has moderate similarity to adenosine deaminase (mouse Ada), which has roles in immune response and various developmental processes adeonsine deaminase; C06G3.5 is orthologous to human ADENOSINE DEAMINASE (ADA; OMIM:102700), which when mutated leads to severe combined immunodeficiency. C06G3.6 C06G3.6 Protein with moderate similarity to C. elegans T12G3.1 gene product zinc finger protein C06G3.7 TR-Se;C06G3.7 Member of the reductase/oxidoreductase protein family, probable selenocysteine-containing thioredoxin reductase pyridine nucleotide-disulphide oxidoreductase; C06G3.7 encodes an homolog of the mammalian thioredoxin reductase isozymes TR1 and TR2; like its mammalian homologs, C06G3.7 has a TGA-encoded C-terminal penultimate selenocysteine (Sec) residue; labelling of C. elegans with selenium-75 demonstrates that TR-Se is the major naturally occurring selenoprotein in C. elegans, and computational analysis indicates that it is probably the only selenoprotein encoded by the genome; the 3'-untranslated region of this gene contains a selenocysteine insertion sequence that is functional in mammalian cell culture; by phylogenetic profiling, C06G3.7 protein is predicted to be mitochondrial. C06G3.8 C06G3.8 Protein containing an OB-fold nucleic acid binding domain, which are found in tRNA synthetases, helicases, and polymerases C06G3.9 C06G3.9 Protein of unknown function, has weak similarity to uncharacterized human KIAA0776 C06G4.2 C06G4.2 Member of the calpain family of cysteine proteases, contains two large subunit III calpain domains, has a region of high similarity to a region of the digestive tract member of the calpain calcium-dependent non-lysosomal proteases (mouse Ncl-4) Calpain; clp-1 encodes a calpain homolog that has significant identity to mammalian calpains over its whole length and that contains motifs typical of calpains, including a thiol (cysteine) protease active site and a Ca[2+]-binding domain; CLP-1 is required, in parallel with TRA-3 but in series with ASP-3 and ASP-3, for degenerative (necrotic-like) cell death in neurons induced by mutations such as mec-4(d), deg-3(d), or gsa-1(gf). C06G4.4 C06G4.4 Protein of unknown function C06G4.5 C06G4.5 Member of the rhodopsin family of G protein-coupled receptors (GPCR), has low similarity to neuropeptide FF receptor 2 (rat Npgpr), which is a G protein-coupled receptor that may play a role in pain modulation, opiate tolerance, and adult feeding behavior G-protein coupled receptor C06G8.1 C06G8.1 Member of the MtN3-saliva family, which contain a region of two transmembrane helices C06G8.2 pep-1;CPTA;C06G8.2;opt1 Member of the proton-coupled oligopeptide transporter (POT) family of membrane transporters oligopeptide transporter; opt-1 encodes a high-affinity, proton-coupled oligopeptide transporter; when expressed in Xenopus ooctyes, OPT-1 exhibits proton-coupled transport activity for a broad spectrum of peptide substrates; opt-1 mRNA is detected at all stages of development, but is expressed at highest levels in late larval and adult stages; additionally, an opt-1::GFP reporter exhibits expression primarily in vulval, pharyngeal, and anal muscles; as loss of opt-1 activity via large-scale RNAi screens does not result in any obvious abnormalities, the precise role of opt-1 in C. elegans development and/or behavior is not yet known. C06G8.3 C06G8.3 Member of the ZIP zinc transporter family, which may be metal transporters C06G8.4 C06G8.4 Protein of unknown function, has high similarity to uncharacterized C. elegans B0547.4 7TM chemoreceptor (srd-family) C06H2.1 C06H2.1 Protein with similarity to D. melanogaster mitochondrial ATP synthase D chain (ATPSYN-D) ATP synthase D chain C06H2.2 C06H2.2 Protein containing a START (Steroidogenic Acute Regulatory protein) domain, which is a lipid-binding domain in StAR, HD-ZIP and signaling proteins, has a region of low similarity to phosphatidylcholine transfer protein (human PCTP) phosphatidylcholine transfer protein C06H2.3 C06H2.3 Protein containing an acetyltransferase (GNAT) domain and a Jumonji (jmjC) domain, has a region of low similarity to a region of protein associated with small stress proteins 1 (rat Pass1), which inhibits rat Hsp27-mediated tolerance to heat shock Acetyltransferase (GNAT) family C06H2.4 C06H2.4 Member of the reduced folate carrier family, which transport reduced folate into cells, has low similarity to thiamine transporter protein 1 (human SLC19A2), which is associated with thiamine responsive megaloblastic anemia (TRMA) folate transporter protein; C06H2.4 is orthologous to the human gene THIAMINE TRANSPORTER 1 (SLC19A2; OMIM:603941), which when mutated leads to disease. C06H2.5 C06H2.5 Protein of unknown function, has weak similarity to C. elegans W01C9.5 Globin C06H2.6 C06H2.6 Protein of unknown function C06H5.1 C06H5.1 Protein containing an F-box domain, which serve as a link between a target protein and a ubiquitin-conjugating enzyme, and a DUF38 domain of unknown function, has weak similarity to C. elegans FOG-2, which is required for the sexual identity of germ cells This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins; this gene's encoded protein also contains an FTH/DUF38 motif, which may also mediate protein-protein interaction. C06H5.2 C06H5.2 Protein containing an F-box domain, which serve as a link between a target protein and a ubiquitin-conjugating enzyme, and a DUF38 domain of unknown function, has weak similarity to C. elegans FOG-2, which is required for the sexual identity of germ cells This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins; this gene's encoded protein also contains an FTH/DUF38 motif, which may also mediate protein-protein interaction. C06H5.6 C06H5.6 Member of the sugar (and other) transporter family, has weak similarity to the proton-organic cation transporter (mouse Slc22a4), which efficiently transports various organic cations and also exhibits low carnitine transport activity C06H5.7 C06H5.7 Protein of unknown function, has weak similarity to C. elegans Y57G11C.27 C07A12.1 ham-2;C07A12.1 Putative transcription factor required for migration of hermaphrodite-specific neurons; downstream target of HOX family member EGL-5 zinc finger protein; The ham-2 gene encodes a C2H2 zinc finger-containing protein required for proper migration of the hermaphrodite-specific neurons (HSNs) and proper attachment of the pharynx to the nose; HAM-2 is expressed in the nuclei of the HSNs during migration, and acts downstream of EGL-5, a posterior group Hox protein, in HSN specification; HAM-2 acts redundantly with UNC-86 to downregulate UNC-43 expression in the HSNs after migration is complete. C07A12.2 C07A12.2 Protein of unknown function C07A12.3 nhr-35;C07A12.3 Putative nuclear hormone receptor, contains two C4-type zinc finger DNA-binding domains and a ligand binding domain, has similarity to human hepatocyte nuclear factors zinc finger protein C07A12.4 pdi-2;C07A12.4 Protein disulfide isomerase, beta subunit of prolyl 4-hydroxylase protein disulfide isomerase; This gene encodes a protein predicted by Eisenberg and coworkers, with 52% accuracy, to be mitochondrial. C07A12.5 C07A12.5 Protein containing five C2H2 type zinc finger domains, which bind nucleic acids zinc finger protein C07A12.7 C07A12.7 Protein containing two VHS domains of unknown function and two GAT domains, has a region of low similarity to a region of signal transducing adaptor molecule 1 (human STAM), which is a putative adaptor protein involved in signal transduction C07A4.1 C07A4.1 Protein containing two RNA recognition motifs (RRM, RBD, or RNP), has moderate similarity to TIA1 cytotoxic granule associated RNA-binding protein-like 1 (human TIAL1), which is a transcriptional repressor that binds platelet factor (human PF4) promoter RNA binding protein C07A4.2 C07A4.2 Putative ortholog of C. elegans C07A4.3 gene product extracellular protein C07A4.3 C07A4.3 Member of the SCP-like extracellular protein family, has a region of low similarity to a region of S. cerevisiae Pry1p, which may have a role in mating efficiency extracellular protein C07A9.1 C07A9.1 Member of the C-type lectin family C-type lectin C07A9.10 C07A9.10 Protein containing a ubiquitin carboxyl-terminal hydrolases family 2 domain Ubiquitin carboxyl-terminal hydrolases family 2 C07A9.11 C07A9.11 Member of the sodium or calcium exchanger protein family of membrane transporters, which regulate intracellular Ca2+ concentrations, has weak similarity to potassium-dependent sodium-calcium exchanger 2 (rat Nckx2), which is a calcium:sodium antiporter Na/Ca, K antiporter C07A9.2 C07A9.2;3J784 Member of the G10 family, which are highly conserved but of unknown function, has moderate similarity to S. cerevisiae Bud31p, which regulates cell growth G10 protein C07A9.3 C07A9.3 Protein containing a protein kinase domain, has a region of high similarity to tousled-like kinase 2 (human TLK2), which is a serine-threonine kinase that exhibits DNA replication-dependent kinase activity that peaks during S-phase serine/threonine kinase; tlk-1 encodes, through alternative splicing, two isoforms of a Tousled-class serine/threonine protein kinase; TLK-1A/B are orthologous to Tousled from A. thaliana; tlk-1(RNAi) embryos have, compared to normal embryos, reduced phosphorylation of the RNA polymerase II C-terminal domain at Serine-2 and methylation of histone H3 at Lysine-36 (posttranslational modifications associated with transcriptional elongation), along with a lethal phenotype consistent with general defects in zygotic transcription; TLK-1A/B have a glutamine/asparagine-rich domain and a putative coil domain. C07A9.4 C07A9.4 Member of the sodium or calcium exchanger protein family of membrane transporters, which regulate intracellular Ca2+ concentrations, has weak similarity to a region of C. elegans F35C12.2, which is a potassium dependent Na/Ca exchanger Na/Ca,K antiporter C07A9.5 C07A9.5 Protein containing an EF hand domain, which are found in signaling, buffering or transport proteins, has weak similarity to a region of alpha actinin 2 (mouse Actn2), which may play a role in muscle cell fusion Actin-binding protein C07A9.6 C07A9.6;C07A9.6 Protein containing two UDP-glucoronosyl and UDP-glucosyl transferase domains and a ubiquitin carboxyl-terminal hydrolases family 2 domain, has a region of low similarity to a region of UDP glycosyltransferase 2 family polypeptide B (human UGT2B) UDP-glucuronosyltransferase C07A9.7 C07A9.7 Protein with weak similarity to S. cerevisiae YPL165C C07A9.8 C07A9.8 Member of the C. elegans putative membrane protein family 8, has low similarity to a region of bestrophin (human VMD2), which plays a role in vision and is associated with Bests disease, adult vitelliform macular dystrophy, and bull's eye maculopathy Putative membrane protein C07A9.9 C07A9.9 Protein of unknown function C07B5.2 C07B5.2 Protein of unknown function C07B5.3 C07B5.3 Protein with moderate similarity to C. elegans F17C11.2 gene product C07B5.4 C07B5.4 Protein containing a pleckstrin homology (PH) domain, which mediate protein-protein and protein-lipid interactions C07B5.5 nuc-1;C07B5.5 Endonuclease with strong similarity to H. sapiens DNase II, involved in DNA degradation during apoptosis The nuc-1 gene encodes a DNase II homolog similar to mammalian and Drosophila DNaseII enzymes and is required for DNA degradation during apoptosis as well as for degradation of dietary DNA during normal feeding; during apoptosis, NUC-1 functions in apoptotic cells at an intermediate stage of DNA degradation, after the killing step, but prior to cell-corpse engulfment. C07B5.6 C07B5.6 Protein of unknown function C07C7.1 C07C7.1 Protein of unknown function C07D10.1 C07D10.1 Protein containing an F-box domain, which serve as a link between a target protein and a ubiquitin-conjugating enzyme C07D10.2 C07D10.2 Protein containing two BTB (BR-C, ttk and babor) or POZ (Pox virus and zinc finger) domains, which are found in some DNA and actin binding proteins and may mediate protein-protein interactions, has low similarity to C. elegans MEL-26 The C07D10.2 gene encodes a protein with a meprin-associated Traf homology (MATH) domain that may be involved in apoptosis. C07D10.3 C07D10.3 Member of the C. elegans Sre G protein-coupled chemoreceptor family, which are putative chemosensory receptors 7TM chemoreceptor, sre family C07D10.4 C07D10.4 Member of the astacin (M12A) family of metalloproteases, has a region of low similarity to a region of the meprin A alpha subunit (PABA peptide hydrolase, human MEP1A), which is found at increased levels in some colon carcinomas Zinc metalloprotease C07D10.5 C07D10.5 Protein of unknown function, has weak similarity to C. elegans F43E2.1 C07D8.2 C07D8.2 Putative ortholog of C. elegans K09E3.1 gene product C07D8.3 C07D8.3 Protein with strong similarity to C. elegans K09E3.1 gene product C07D8.4 C07D8.4 Protein of unknown function C07D8.5 C07D8.5 Member of the aldo-keto reductase family, which include some related monomeric NADPH-dependent oxidoreductases, has a region of high similarity to a region of aldose reductase (rat Akr1b1), which acts in the polyol pathway and in xenobiotic metabolism C07D8.6 C07D8.6 Member of the aldo-keto reductase family, which include some related monomeric NADPH-dependent oxidoreductases, has moderate similarity to aldose reductase (aldehyde dehydrogenase, human AKR1B1), which catalyzes the reduction of glucose to sorbitol aldehyde reductase C07E3.1 C07E3.1 Protein containing a G-patch domain, which are found in RNA processing proteins, has low similarity to uncharacterized human TIP39 C07E3.10 C07E3.10 Protein of unknown function C07E3.2 C07E3.2 Protein with low similarity to S. cerevisiae Noc2p, which is involved in biogenesis of the 60S ribosome C07E3.3 C07E3.3 Protein with weak similarity to human and S. cerevisiae mucins (cell surface flocculins) C07E3.4 C07E3.4 Member of the protein-tyrosine phosphatase family, which are involved in cell growth control, proliferation, differentiation and transformation, has strong similarity to uncharacterized C. elegans F57H12.5 Protein-tyrosine phosphatase C07E3.5 C07E3.5 Protein of unknown function C07E3.6 C07E3.6 Protein of unknown function C07E3.7 C07E3.7 Protein containing a homeobox domain (homeodomain), which are found in transcription factors C07E3.8 C07E3.8 Protein of unknown function, has low similarity to a region of C. elegans PHA-1, which is involved in pharyngeal development C07E3.9 C07E3.9 Member of the phospholipase A2 family, has moderate similarity to group IB phospholipase A2 (human PLA2G1B), which is a pancreatic secreted phospholipase A2 that hydrolyzes the phospholipid sn-2 ester bond and has a role in signal transduction phospholipase A2 C07F11.1 tol-1;C07F11.1 Putative ortholog of D. melanogaster Tollo (Tollo), required for embryonic development The tol-1 gene encodes a predicted transmembrane protein that is the sole C. elegans Toll-like receptor (TLR); TOL-1 is required for proper embryonic development and for pathogen avoidance behavior, and is expressed primarily in the nervous system. C07F11.2 C07F11.2 Protein of unknown function, has strong similarity to C. elegans C07F11.E C07G1.1 C07G1.1 Member of the trypsin family of serine proteases, has moderate similarity to proprostasin (human PRSS8), which is a seminal fluid serine-type endopeptidase that may act as a suppressor of invasive prostate cancer and is upregulated in ovarian cancer peptidase; try-2 encodes a homolog of human TRYP1 and ELA2; mutation of human TRYP1 or ELA2 leads, respectively, to hereditary pancreatitis (OMIM:276000) or cyclic haematopoiesis (OMIM:162800). C07G1.2 C07G1.2 Protein containing a kringle domain, two low-density lipoprotein (LDL) receptor class A domains, a PAN domain, and a C-type lectin domain LDL-receptor domain protein C07G1.3 pct-1;C07G1.3 Protein containing two protein kinase domains, has a region of high similarity to PCTAIRE protein kinase 1 (human PCTK1), which is a cell-cycle regulated serine-threonine protein kinase that may be associated with X chromosome-linked heritable disorders ser/thr protein kinase C07G1.5 C07G1.5 Protein containing a FYVE zinc finger domain, a ubiquitin interaction motif, and a VHS domain of unknown function, has moderate similarity to hepatocyte growth factor regulated tyrosine kinase substrate (human HGS) The protein product of this gene is predicted to contain a glutamine/asparagine (Q/N)-rich ('prion') domain, by the algorithm of Michelitsch and Weissman (as of the WS77 release of WormBase, i.e., in wormpep77). C07G1.6 C07G1.6 Protein of unknown function C07G1.7 C07G1.7 Protein with moderate similarity to C. elegans M199.2 gene product C07G2.1 cej-1;C07G2.1 Protein containing three chitin binding peritrophin-A domains, which contain six conserved cysteines that probably form three disulfide bridges Endochitinase (partial); cej-1 encodes a protein with a chitin binding peritrophin-A domain that is required, in conjunction with B0280.5, for early embryonic development; cej-1 mRNA is expressed specifically in the adult hermaphrodite germ line, is a direct target of GLD-1, and has an RNAi phenotype consistent with the hypothesis that CEJ-1 is an effector of GLD-1 in the germline. C07G2.2 C07G2.2 Protein containing a bZIP (basic-leucine zipper) transcription factor domain bZIP transcription factor C07G2.3 cct-5;C07G2.3 Component of the cytosolic chaperonin containing T-complex polypeptide-1 TCP-1 like chaperonin; A homolog of the mouse chaperonin Ccte that affects protein folding; it is expressed at all life stages. C07G3.10 C07G3.10 Protein of unknown function C07G3.2 C07G3.2 Protein of unknown function, has high similarity to C. elegans T24A6.7 C07G3.3 C07G3.3 Member of the 7-transmembrane chemoreceptor family of G protein-coupled receptors (GPCR), has low similarity to C. elegans ODR-10, which is a G protein-coupled receptor involved in odorant response 7TM chemoreceptor, str family C07G3.4 C07G3.4 Member of the 7-transmembrane chemoreceptor family of G protein-coupled receptors (GPCR), has low similarity to C. elegans ODR-10, which is a G protein-coupled receptor involved in odorant response 7TM chemoreceptor, str family C07G3.5 C07G3.5 Member of the 7-transmembrane chemoreceptor family of G protein-coupled receptors (GPCR), has low similarity to C. elegans ODR-10, which is a G protein-coupled receptor involved in odorant response 7TM chemoreceptor, str family C07G3.6 C07G3.6 Member of the 7-transmembrane chemoreceptor family of G protein-coupled receptors (GPCR), has low similarity to C. elegans ODR-10, which is a G protein-coupled receptor involved in odorant response 7TM chemoreceptor, str family C07G3.7 C07G3.7 Protein containing a DUF40 domain of unknown function, which contain four conserved cysteines, has high similarity to uncharacterized C. elegans Y113G7B.9 C07G3.8 C07G3.8 Protein with strong similarity to C. elegans K03B4.6 gene product C07G3.9 C07G3.9 Protein containing a UDP-glucoronosyl and UDP-glucosyl transferase domain, has weak similarity to UDP glycosyltransferase 1 family polypeptide A1 (human UGT1A), which acts in bilirubin conjugation and plays a role in Gilbert and Crigler-Najjar syndromes C07H4.1 C07H4.1 Protein of unknown function C07H4.2 clc-5;clh-5;C07H4.2 Chloride channel protein chloride channel protein; The clh-5 gene encodes a chloride channel, whose human homologs include CLC1 and CLCN5; the latter homolog is imvolved in receptor-mediated endocytosis. C07H6.1 C07H6.1 Protein containing one BRCA1 (breast cancer type 1) C terminus (BRCT) and one ATP-dependent DNA ligase domain, has weak similarity to ATP-dependent DNA ligase IV (human LIG4), which is a DNA repair enzyme that is associated with radiosensitive leukemia C07H6.2 C07H6.2 Small protein of unknown function, has moderate similarity to uncharacterized C. elegans K10H10.7 C07H6.3 C07H6.3 Protein with weak similarity to cytoplasmic linker protein (CLIP) associating protein 2 (human CLASP2), which is a microtubule-binding protein that is also likely to bind CLIP family members and may play a role in microtubule stabilization C07H6.4 C07H6.4 Protein containing an RNA recognition motif (RRM, RBD, or RNP) and a Surp module (SWAP domain), which may bind RNA, has low similarity to uncharacterized human KIAA0332 Probable RNA binding protein C07H6.5 cgh-1;C07H6.5 Probable DEAD-box type RNA helicase; required for gametogenesis and prevention of germline apoptosis ATP-dependent RNA helicase; The ortholog of a RNA helicase ste13/ME31B/RCK/p54 that is required for oocyte and sperm function and the prevention of physiological germline-associated apoptosis; it is expressed in the early embryo and germline and localizes to P granules. C07H6.6 rad-5;clk-2;C07H6.6 DNA damage checkpoint protein; similar to yeast telomere binding protein Tel2p; involved in regulation of biological clock functions The clk-2 gene encodes an ortholog of the telomere length-regulating protein Tel2p from S. cerevisiae; clk-2 mutations extend lifespan, indicating that CLK-2 positively mediates some aspect of normal aging. C07H6.7 lin-39;ceh-15;C07H6.7 Homeodomain transcription factor involved in cell fate determination in a variety of cell lineages within the central body region C. elegans homeobox gene lin-39 C07H6.8 cux-7;C07H6.8 Protein of unknown function, has moderate similarity to 721P protein (human DXYS155E) cux-7 encodes an conserved but unfamiliar protein orthologous to the human gene XE7 and the Drosophila gene CG2179-PA; since cux-7 is in an operon with clk-2, CUX-7 might have some role in telomere maintenance, development or rhythmic behavior; however, cux-7 currently has no known function, and is dispensable for viability and gross morphology in mass RNAi screens. C07H6.9 C07H6.9 Protein of unknown function C08A9.1 sod-3;MnSOD;C08A9.1 Manganese superoxide dismutase superoxide dismutase; sod-3 encodes a iron/manganese superoxide dismutase, predicted to be mitochondrial, that might defend against oxidative stress and promote normal lifespan; sod-3 mRNA levels are diminished by mutation of daf-16, and heterologously expressed SOD-3 in E. coli protects against methyl viologen-induced oxidative stress. C08A9.3 C08A9.3 Protein of unknown function, has high similarity to uncharacterized C. elegans C30E1.2 C08A9.4 C08A9.4 Protein of unknown function, has high similarity to uncharacterized C. elegans C30E1.3 C08A9.5 C08A9.5 Protein of unknown function, has moderate similarity to uncharacterized C. elegans C30E1.4 C08A9.6 C08A9.6 Protein of unknown function, has high similarity to uncharacterized C. elegans C08A9.8 C08A9.7 C08A9.7 Protein of unknown function, has moderate similarity to uncharacterized C. elegans C41H7.4 C08A9.8 C08A9.8 Protein of unknown function, has high similarity to uncharacterized C. elegans C08A9.6 C08A9.9 C08A9.9 Protein of unknown function, has high similarity to uncharacterized C. elegans K09E3.5 C08B11.1 zyg-11;C08B11.1 Protein required for zygote formation Leucine Rich Repeat (2 copies) C08B11.2 hda-2;C08B11.2 Protein with high similarity to histone deacetylase 1 (human HDAC1), which is a deacetylase and transcriptional corepressor that controls cell proliferation, member of the histone deacetylase family, which catalyze removal of acetyl groups from histones transcriptional regulatory protein (RPD3) C08B11.3 C08B11.3 Member of the ARID DNA binding domain protein family Zinc finger, C2H2 type C08B11.4 nrf-6;C08B11.4 Protein predicted to span a membrane twelve times, member of a family of C. elegans and D. melanogaster proteins C08B11.5 sap-49;SAP49;C08B11.5 Putative U2 snRNP-associated protein, putative ortholog of human spliceosome associated protein SAP49 and yeast Hsh49p Poly(A) RNA binding protein C08B11.6 C08B11.6 Member of the actin family, which are major cytoskeletal proteins, has low similarity to actin (C. albicans Act1p), which is involved in cell polarization, endocytosis, and other cytoskeletal functions actin C08B11.7 C08B11.7 Putative ubiquitin carboxyl-terminal hydrolase, has strong similarity to human ubiquitin carboxyl-terminal hydrolase BAP1 thiolesterase C08B11.8 C08B11.8 Protein with moderate similarity to dolichyl-P-Glc:Man9GlcNAc2-PP-dolichylglucosyltransferase (human ALG6), which functions in dolichyl pyrophosphate-linked Glc3Man9GlcNAc2 synthesis C08B11.9 C08B11.9 Protein of unknown function C08B6.1 C08B6.1 Protein containing a UDP-glucoronosyl and UDP-glucosyl transferase domain, has weak similarity to UDP glycosyltransferase 2 family polypeptide B7 (human UGT2B7), which glucuronidates androgens, retinoids, lipids and specific drugs UDP-glucuronosyl transferase C08B6.10 C08B6.10 Protein of unknown function proline rich proteoglycan C08B6.2 C08B6.2 Protein with strong similarity to C. elegans C44H9.6 gene product C08B6.3 C08B6.3 Protein containing a DUF138 domain of unknown function, has high similarity to uncharacterized C. elegans F46F5.7 C08B6.4 C08B6.4 Member of the plant chitinase class I family, which hydrolyze the beta-1,4-N-acetyl-D-glucosamine bonds in chitin polymers destroying chitin-containing cell walls of pathogens, has strong similarity to uncharacterized C. elegans R10D12.15 chitinase C08B6.5 C08B6.5 Protein containing a ligand-gated ion channel domain, which are found in ionotropic glutamate receptors and NMDA receptors glutamate receptor transmembranous domain C08B6.6 C08B6.6 Protein of unknown function C08B6.7 C08B6.7 Protein containing five WD domains (WD-40 repeat), which may mediate protein-protein interactions, has moderate similarity to dystrophia myotonica-containing WD repeat (mouse Dm9), which is a putative signaling protein associated with myotonic dystrophy 59 protein C08B6.8 C08B6.8 Protein with high similarity to human DKFZP566E144, which is a 3'-5' exonuclease, member of the exonuclease family YJER protein C08B6.9 C08B6.9 Member of the UBA-THIF-type NAD-FAD binding fold family, has low similarity to SUMO-1 activating enzyme 1 subunit (sentrin-activating enzyme complex, human SAE1), which catalyzes the transfer of SUMO-1 (UBL1), SUMO2 and SUMO3 ubiquitin activating enzyme; aos-1 encodes the C. elegans ortholog of Saccharomyces cerevisiae Aos1p and human SUMO-1 activating enzyme E1 N subunit; by homology, AOS-1 is predicted to form, with a catalytic subunit, UBA-2, a heterodimeric enzyme that activates the ubiquitin-like protein SMO-1/SUMO in preparation for its covalent attachment to target proteins to regulate their subcellular localization and/or stability; in C. elegans, AOS-1 is required for embryonic and larval development, as well as for proper Hox gene regulation; uba-2/aos-1(RNAi) animals that survive embryogenesis show ectopic expression of EGL-5 and ectopic anterior sensory ray formation. | aos-1 encodes the C. elegans ortholog of Saccharomyces cerevisiae Aos1p and human SUMO-1 activating enzyme E1 N subunit; by homology, AOS-1 is predicted to play a role in protein targeting and/or stabilization and to form, with UBA-2, a heterodimeric enzyme that activates the ubiquitin-like protein SUMO in preparation for its covalent attachment to target proteins; loss of aos-1 activity via large-scale RNAi screens indicates that AOS-1 is required for embryonic and larval development. C08C3.1 egl-5;ceh-11;C08C3.1 Homeodomain transcription factor required for posterior patterning; similar over the homeodomain to many human and D. melanogaster homeodomain transcription factors egl-5 encodes a homeodomain transcription factor, orthologous to Drosophila Abd-B and the vertebrate Hox9-13 proteins, that is required for specification of the HSN cell fate and of cell fates within the tail region; EGL-5 is expressed in the posterior of the animal. C08C3.2 C08C3.2 Protein containing a BTB (BR-C, ttk and babor) or POZ (Pox virus and zinc finger) domain, which may mediate protein-protein interactions, and a meprin and TRAF homology (MATH) domain, has high similarity to uncharacterized C. elegans F40B1.1 C08C3.3 mab-5;C08C3.3 Homeodomain transcription factor involved in postembryonic development; has similarity over the homeodomain to many human and D. melanogaster homeodomain transcription factors C08C3.4 C08C3.4 Protein of unknown function, has weak similarity to C. elegans R10E4.1 C08D8.1 C08D8.1 Protein of unknown function, has low similarity to uncharacterized C. elegans F36G9.3 C08D8.2 C08D8.2 Protein of unknown function, has a region of low similarity to a region of tropomodulin (human TMOD), which is a putative capping protein of the actin thin filament pointed end and cytoskeletal lattice integral component that regulates cell adhesion C08E3.1 C08E3.1 Protein of unknown function, has very strong similarity to uncharacterized C. elegans C08E3.13 C08E3.10 C08E3.10 Protein containing an F-box domain, which serve as a link between a target protein and a ubiquitin-conjugating enzyme, and a DUF38 domain of unknown function, has low similarity to C. elegans T07D3.1, which may function in germ-line cell differentiation This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins; this gene's encoded protein also contains an FTH/DUF38 motif, which may also mediate protein-protein interaction. C08E3.11 C08E3.11 Protein with strong similarity to C. elegans C08E3.8 gene product C08E3.12 C08E3.12 Protein containing a DUF38 domain of unknown function, has a region of low similarity to a region of C. elegans T07D3.1, which functions in gametogenesis and positive regulation of body size C08E3.13 C08E3.13 Protein of unknown function, has very strong similarity to uncharacterized C. elegans C08E3.1 C08E3.2 C08E3.2 Protein containing a BTB (BR-C, ttk and babor) or POZ (Pox virus and zinc finger) domain, which are found in some DNA and actin binding proteins and may mediate protein-protein interactions, has moderate similarity to uncharacterized C. elegans B0047.2 C08E3.3 C08E3.3 Protein containing a BTB (BR-C, ttk and babor) or POZ (Pox virus and zinc finger) domain, which may mediate protein-protein interactions, and a meprin and TRAF homology (MATH) domain, has moderate similarity to uncharacterized C. elegans F45C12.11 C08E3.4 C08E3.4 Protein containing a DUF38 domain of unknown function, has low similarity to a region of C. elegans T07D3.1, which functions in gametogenesis and positive regulation of body size C08E3.5 C08E3.5 Protein containing an F-box domain, which serve as a link between a target protein and a ubiquitin-conjugating enzyme, and a DUF38 domain of unknown function, has low similarity to C. elegans T07D3.1, which may serve in germ-line stem cell differentiation This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins; this gene's encoded protein also contains an FTH/DUF38 motif, which may also mediate protein-protein interaction. C08E3.6 C08E3.6 Protein containing an F-box domain, which serve as a link between a target protein and a ubiquitin-conjugating enzyme, and a DUF38 domain of unknown function, has low similarity to C. elegans T07D3.1, which may serve in germ-line stem cell differentiation This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins; this gene's encoded protein also contains an FTH/DUF38 motif, which may also mediate protein-protein interaction. C08E3.7 C08E3.7 Protein containing an F-box domain, which serve as a link between a target protein and a ubiquitin-conjugating enzyme, and a DUF38 domain of unknown function, has low similarity to C. elegans T07D3.1, which may serve in germ-line stem cell differentiation This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins; this gene's encoded protein also contains an FTH/DUF38 motif, which may also mediate protein-protein interaction. C08E3.8 C08E3.8 Protein containing an F-box domain, which serve as a link between a target protein and a ubiquitin-conjugating enzyme, and a DUF38 domain of unknown function, has low similarity to C. elegans T07D3.1, which may function in germ-line cell differentiation This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins; this gene's encoded protein also contains an FTH/DUF38 motif, which may also mediate protein-protein interaction. C08E3.9 C08E3.9 Protein containing a DUF38 domain of unknown function, has low similarity to C. elegans T07D3.1, which functions gametogenesis and positive regulation of body size C08E8.1 C08E8.1 Protein with strong similarity to C. elegans Y41C4A.11 gene product C08E8.2 C08E8.2 Protein with strong similarity to C. elegans F57C2.5 gene product C08E8.3 C08E8.3 Protein with moderate similarity to C. elegans Y51B11_80.A gene product C08E8.4 C08E8.4 Protein with moderate similarity to C. elegans C07G3.2 gene product C08F1.1 C08F1.1 Protein containing four meprin and TRAF homology (MATH) domains, has low similarity to uncharacterized C. elegans C08F1.4 C08F1.3 C08F1.3 Protein containing an F-box domain, which serve as a link between a target protein and a ubiquitin-conjugating enzyme, has high similarity to uncharacterized C. elegans T08E11.6 This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins; its encoded protein also contains a Pfam-B45 motif of presently unknown function. C08F1.4 C08F1.4 Protein containing five meprin and TRAF homology (MATH) domains, has moderate similarity to uncharacterized C. elegans T16A1.1 The C08F1.4 gene encodes a protein closely similar to F36H5.2, which has a meprin-associated Traf homology (MATH) domain and may be involved in apoptosis. C08F1.5 C08F1.5 Protein containing seven meprin and TRAF homology (MATH) domains C08F1.6 C08F1.6 Protein of unknown function, has high similarity to uncharacterized C. elegans F36H5.4 C08F1.8 C08F1.8 Putative ortholog of C. elegans C08F1.5 gene product reverse transcriptase C08F1.9 C08F1.9 Member of the reverse transcriptase protein family, which are RNA-dependent DNA polymerases, has very strong similarity to uncharacterized C. elegans F28E10.3 C08F11.1 C08F11.1 Protein of unknown function, has high similarity to uncharacterized C. elegans F07C6.3 C08F11.10 C08F11.10 Protein of unknown function, has high similarity to uncharacterized C. elegans W03B1.3 C08F11.11 C08F11.11 Protein of unknown function, has moderate similarity to uncharacterized C. elegans Y45F10C.2 C08F11.12 C08F11.12 Protein of unknown function, has very strong similarity to uncharacterized C. elegans Y45F10C.2 C08F11.13 C08F11.13 Protein with moderate similarity to C. elegans F56G4.1 gene product C08F11.14 C08F11.14 Putative ortholog of S. cerevisiae MLS1 gene product (Malate synthase 1, functions in glyoxylate cycle, has near identity to Dal7p) C08F11.2 C08F11.2 Protein of unknown function, has low similarity to uncharacterized C. elegans ZK697.1 C08F11.3 C08F11.3 Protein with strong similarity to C. elegans F56G4.1 gene product C08F11.4 C08F11.4 Protein containing a DUF215 domain of unknown function, has high similarity to uncharacterized C. elegans F36G9.6 C08F11.5 C08F11.5 Protein containing a DUF38 domain of unknown function, and an F-box domain, which serve as a link between a target protein and a ubiquitin-conjugating enzyme, has low similarity to C. elegans FOG-2, which required for the sexual identity of germ cells This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins; this gene's encoded protein also contains an FTH/DUF38 motif, which may also mediate protein-protein interaction. C08F11.7 C08F11.7 Protein with weak similarity to C. elegans csp-1 gene product C08F11.8 C08F11.8 Protein containing a UDP-glucoronosyl and UDP-glucosyl transferase domain, has low similarity to UDP glycosyltransferase 1 A3 (human UGT1A3), which converts hydrophobic xenobiotic and endobiotic compounds to hydrophilic compounds for removal from cells UDP-glucoronosyl and UDP-glucosyl transferases C08F11.9 C08F11.9 Protein containing a DUF216 domain of unknown function, has moderate similarity to uncharacterized C. elegans H12I19.2 C08F8.1 C08F8.1 Protein with weak similarity to the human chaperone protein PFDN1 (prefoldin), a protein that delivers unfolded proteins to cytosolic chaperonin C08F8.2 C08F8.2 Protein containing a helicase conserved C-terminal domain, has low similarity to S. cerevisiae Suv3p, which is a mitochondrial RNA helicase and component of mitochondrial NTP-dependent 3'-5' exonuclease responsible for degradation of group I intron RNA ATP-dependent RNA helicase C08F8.3 C08F8.3 Protein of unknown function C08F8.4 C08F8.4 Member of the membrane bound O-acyl transferase (MBOAT) family, which are found in acyltransferase enzymes, has high similarity to uncharacterized C. elegans ZK550.1 C08F8.5 C08F8.5 Protein containing two F-box domains, which serve as a link between a target protein and a ubiquitin-conjugating enzyme This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins; its encoded protein also contains a Pfam-B45 motif of presently unknown function. C08F8.6 C08F8.6 Protein containing a protein kinase domain, has low similarity to casein kinase 1 epsilon (mouse Csnk1e), which is a serine-threonine protein kinase with broad substrate specificity that may function in DNA repair and regulation of circadian rhythm serine/threonine kinase C08F8.7 rrp-1;C08F8.7 Protein with high similarity to Ras related protein 1b (human RAP1B), which is involved in cell cycle progression, cellular proliferation, and possibly cAMP-responsive tumorigenesis, member of the Ras superfamily of GTP binding proteins RAS-related protein C08F8.8 nhr-67;C08F8.8 Putative nuclear hormone receptor, contains two C4-type zinc finger domains, has strong similarity to D. melanogaster and human TAILLESS proteins nuclear hormone receptor C08G5.1 C08G5.1 Protein containing a WSN domain of unknown function, has moderate similarity to uncharacterized C. elegans R06B10.2 C08G5.2 C08G5.2 Protein of unknown function, has low similarity to uncharacterized C. elegans M02B7.1 C08G5.3 C08G5.3 Protein of unknown function, has low similarity to uncharacterized C. elegans Y9C9A.1 C08G5.4 C08G5.4 Protein containing a C2 domain, which may be involved in calcium-dependent phospholipid binding, has low similarity to a region of synaptotagmin 7 (mouse Syt7), which is involved in synaptic vesicle fusion C08G5.5 C08G5.5 Protein of unknown function C08G5.6 C08G5.6 Protein of unknown function C08G9.2 C08G9.2 Member of the antistasin family, contains nine WAP-type (Whey Acidic Protein) four-disulfide core domains, six thyroglobulin type-1 repeats, and a kunitz or bovine pancreatic trypsin inhibitor domain, has a region of low similarity to mouse Slpi C08H9.1 C08H9.1 Member of the serine carboxypeptidase family, has low similarity to protective protein for beta-galactosidase (cathepsin A, human PPGB), which has serine carboxypeptidase activity and may be associated with galactosialidosis upon gene mutation serine carboxypeptidase C08H9.10 C08H9.10 Member of the glycosyl hydrolase 18 family, has a region of weak similarity to a region of chitinase 1 (chitotriosidase, human CHIT1), which is a chitinase that is implicated in chitotriosidase deficiency upon mutation chitinase C08H9.11 C08H9.11 Member of the glycosyl hydrolase 18 family, has a region of weak similarity to a region of chitinase 1 (chitotriosidase) (human CHIT1), which catalyzes the hydrolysis of chitin and is elevated in patients with Gaucher disease chitinase C08H9.12 C08H9.12 Member of the glycosyl hydrolase 18 family, has a region of weak similarity to chitinase 3-like 3 (mouse Chi3l3), which is a lectin with chitinase activity that plays a role in response to infection with chitin-bearing microorganisms chitinase C08H9.13 C08H9.13 Member of the glycosyl hydrolase 18 family, has low similarity to chitinase 1 (chitotriosidase) (human CHIT1), which is elevated in patients with Gaucher disease and is associated with chitotriosidase deficiency chitinase C08H9.14 C08H9.14 Member of the glycosyl hydrolase 18 family, has weak similarity to chitinase 3-like 1 (cartilage glycoprotein-39) (human CHI3L1), which binds chitin but does not have chitinase activity and is expressed in rheumatoid arthritis cartilage and synovial cells chitinase C08H9.2 C08H9.2 Protein containing 14 KH domains, which may bind RNA, has moderate similarity to high density lipoprotein binding protein (human HDLBP), which binds high density lipoproteins, mRNA and tRNA, and is involved in mRNA stability high-density lipoprotein-binding protein C08H9.3 C08H9.3 Protein of unknown function, has a region of moderate similarity to a region of S. cerevisiae Alg8p, which is a glucosyltransferase of the endoplasmic reticulum that has a role in adding glucose to the dolichol-linked oligosaccharide precursors glucosyltransferase C08H9.4 C08H9.4 Member of the glycosyl hydrolase 18 family, has a region of weak similarity to chitinase 3-like 3 (mouse Chi3l3), which is a lectin with chitinase activity and a chemotactic for eosinophils, bone marrow polymorphonuclear leukocytes, and T lymphocytes chitinase C08H9.5 old-1;tkr-1;C08H9.5 Putative receptor tyrosine protein kinase; similar to human and D. melanogaster fibroblast growth factor receptor-related protein kinases; overproduction extends lifespan tyrosine-protein kinase (KIN15/KIN16 subfamily) C08H9.6 C08H9.6 Member of the glycosyl hydrolase 18 family, has weak similarity to chitinase 3-like 1 (cartilage glycoprotein-39, human CHI3L1), which binds chitin but does not have chitinase activity and is expressed in rheumatoid arthritis cartilage and synovial cells chitinase C08H9.7 C08H9.7 Member of the glycosyl hydrolase 18 family, has a region of weak similarity to a region of chitinase 1 (chitotriosidase, human CHIT1), which catalyzes the hydrolysis of chitin and is elevated in patients with Gaucher disease chitinase C08H9.8 C08H9.8 Protein containing two protein kinase domains, has low similarity to C. elegans KIN-15, which is a receptor tyrosine protein kinase tyrosine-protein kinase (2 domains) C09B7.1 C09B7.1 Member of the rhodopsin family of G protein-coupled receptors (GPCR), has low similarity to 5-hydroxytryptamine (serotonin) receptor 7 (rat Htr7), which is a G protein-coupled receptor that stimulates adenylyl cyclase G-protein coupled receptor C09B7.2 C09B7.2 Protein with strong similarity to C. elegans C09H10.5 gene product transposase C09B8.1 ipp-5;C09B8.1 Protein containing an inositol polyphosphate phosphatase catalytic domain, has low similarity to inositol polyphosphate-5-phosphatase 40kD (5 phosphatase II, human INPP5A), which hydrolyzes inositol phosphates and is involved in signal transduction ipp-5 encodes a type I inositol 5-phosphatase homolog; ipp-5 acts downstream of let-23 to negatively regulate IP3 signaling and is involved in spermathecal contractions during ovulation; an ipp-5::gfp transcriptional reporter is expressed in the adult distal spermatheca and weakly in the proximal sheath. C09B8.3 C09B8.3 Protein of unknown function, has weak similarity to C. elegans F01D5.6 C09B8.4 C09B8.4 Protein of unknown function, has moderate similarity to uncharacterized C. elegans T10B11.6 C09B8.5 C09B8.5 Protein of unknown function C09B8.6 C09B8.6;hsp25 A chaperonin and member of the HSP20 family of heat shock proteins Small heat shock protein C09B8.7 pak-1;C09B8.7;CePAK Serine/threonine protein kinase with strong similarity to human and D. melanogaster p21-activated protein kinases, may interact with CeRac-1 and CDC-42 to mediate hypodermal cell shape changes during embryonic elongation Serine/threonine protein kinase; pak-1 is orthologous to the human gene P21-ACTIVATED KINASE 3 (PAK3; OMIM:300142), which when mutated leads to nonsyndromic mental retardation. C09B8.8 C09B8.8 Protein of unknown function C09B9.1 C09B9.1 Protein of unknown function, has weak similarity to C. elegans C15C8.1 C09B9.2 C09B9.2 Protein of unknown function, has low similarity to uncharacterized C. elegans F58D5.8 C09B9.3 C09B9.3 Member of the C. elegans putative membrane protein family 8, has a region of low similarity to a region of bestrophin (human VMD2), which plays a role in vision and causes Bests disease, adult vitelliform macular dystrophy, and bull's eye maculopathy C09B9.4 C09B9.4 Protein with low similarity to casein kinase 1 alpha 1 (human CSNK1A1), which is a serine/threonine protein kinase that may play a role in Alzheimer's disease ser/thr protein kinase C09B9.5 C09B9.5 Protein of unknown function C09B9.6 msp-55;C09B9.6 Member of the major sperm-specific protein (MSP) family major sperm protein; msp-55 encodes a member of the major sperm protein family. C09B9.7 C09B9.7 Protein of unknown function, has moderate similarity to uncharacterized C. elegans C01G5.4 C09C7.1 zig-4;C09C7.1 Putative member of Immunoglobulin superfamily IG-like C2-type domains C09D1.1 unc-89;phm-1;C09D1.1 Muscle cell protein required for coordinated locomotion, member of the immunoglobulin protein family immunoglobin-like protein C09D1.2 C09D1.2 Protein containing a C-type lectin domain, which mediate calcium-dependent carbohydrate recognition C09D4.1 C09D4.1 Member of the sugar (and other) transporter family, has high similarity to uncharacterized human FLJ20371 This gene encodes a protein predicted by Eisenberg and coworkers, with 52% accuracy, to be mitochondrial. C09D4.2 C09D4.2 Protein of unknown function C09D4.3 C09D4.3 Protein containing a protein kinase domain, has low similarity to casein kinase 1 gamma 3 (rat Csnk1g3), which is a serine-threonine protein kinase that may play roles in cell growth and in morphogenesis SER/THR protein kinase C09D4.4 C09D4.4 Protein of unknown function C09D4.5 C09D4.5 Protein with high similarity to ribosomal protein L19 (S. cerevisiae Rpl19bp), which is a structural ribosomal protein, contains a ribosomal L19e domain, which are present in the large ribosomal subunit 60S ribosomal protein L19; rpl-19 encodes a large ribosomal subunit L19 protein. C09D4.6 C09D4.6 Protein of unknown function C09D8.2 ptp-3;C09D8.1;C09D8.2 Member of the protein-tyrosine phosphatase family, contains twelve fibronectin type III domains and three immunoglobulin domains, has moderate similarity to protein tyrosine phosphatase receptor type D (human PTPRD) C09E10.2 C09E10.2 Putative ortholog of C. elegans dgk-1 gene product diacylglycerol kinase; The dgk-1 gene encodes an ortholog of diacylglyerol kinase that affects movement, egg laying, and synaptic transmission; it genetically interacts with the goa-1 and egl-30 signaling pathways, and is expressed in neurons. C09E7.1 C09E7.1 Putative ortholog of C. elegans C09E7.G gene product 7TM chemoreceptor, srxa family C09E7.2 C09E7.2 Putative ortholog of C. elegans C09E7.G gene product PQN-10 encodes an unfamiliar protein, with limited similarity to F27B3.6, that has a glutamine/asparagine-rich domain. C09E7.3 C09E7.3 Putative ortholog of C. elegans C09E7.F gene product C09E7.4 C09E7.4 Putative ortholog of C. elegans C09E7.E gene product C09E7.5 C09E7.5 Protein with strong similarity to C. elegans C09E7.9 gene product C09E7.6 C09E7.6 Putative ortholog of C. elegans C09E7.C gene product C09E7.7 C09E7.7 Putative ortholog of C. elegans C09E7.B gene product C09E7.8 C09E7.8 Putative ortholog of C. elegans C09E7.A gene product C09E7.9 C09E7.9 Putative ortholog of C. elegans C09E7.C gene product C09E8.1 C09E8.1 Putative transporter, has weak similarity to a number of human and C. elegans transporters C09E8.2 C09E8.2 Member of the class 2 lipase family, has moderate similarity to uncharacterized C. elegans F58G1.5 C09E8.3 C09E8.3 Protein of unknown function, has moderate similarity to uncharacterized C. elegans W02B8.3 C09E9.1 C09E9.1 Protein of unknown function, has weak similarity to DNA-directed RNA polymerase subunit A' of Thermococcus celer, has weak similarity to human lung cancer candidate FUS1 C09E9.2 C09E9.2 Protein of unknown function, has high similarity to uncharacterized C. elegans F38A1.13 C09F12.1 C09F12.1 Protein of unknown function, has low similarity to uncharacterized C. elegans T05A10.2 clc-1 encodes a claudin homolog, closely similar to CLC-2, that is required for normal cohesion of apical junctions in epithelia; claudins are integral membrane proteins with four transmembrane sequences that are found in mammalian tight junctions (TJs), induce TJs when transgenically expressed in cells normally lacking them, and can mediate the specific conductance of of specific ions (e.g., magnesium or calcium) through TJs while blocking the flow of water; CLC-1 maintains the impermeability ('barrier function') of epithelia, since clc-1(RNAi) animals have abnormal permeability of the pharynx to dyes; clc-1 is expressed in spermatheca, pharynx, intestine, hypodermis, the excretory-secretory system, and the cell-cell junctions of the vulva; in pharyngeal cells, CLC-1 colocalizes with AJM-1 in long thin lines, parallel to the pharyngeal axis and lining the lumenal surface, that appear to correspond with apical intercellular junctions. C09F12.2 C09F12.2 Protein of unknown function C09F5.1 C09F5.1 Protein with strong similarity to C. elegans W01C9.3 gene product C09F5.2 C09F5.2 Protein of unknown function C09F5.3 C09F5.3 Protein containing seven C2H2 type zinc finger domains, which bind nucleic acids, has weak similarity to a region of OLF1-EBF associated zinc finger protein (human OAZ), which may partner with either Smads or Olf1-EBF to regulate transcription C09F9.1 C09F9.1 Protein of unknown function, has high similarity to uncharacterized C. elegans F38A5.8 C09F9.2 C09F9.2 Protein containing three trypsin inhibitor-like cysteine rich domains C09F9.3 C09F9.3 Protein containing four ankyrin (Ank) repeats, which may mediate protein-protein interactions, has a region of high similarity to breast cell glutaminase (phosphate-activated glutaminase, human GA), which is involved in glutamine metabolism Ank repeat C09F9.4 C09F9.4 Putative ortholog of C. elegans C09F9.2 gene product C09F9.5 C09F9.5 Protein containing two ankyrin (Ank) repeats, which may mediate protein-protein interactions, has a region of high similarity to a region of breast cell glutaminase (phosphate-activated glutaminase, human GA), which is involved in glutamine metabolism C09G1.1 C09G1.1 Protein of unknown function PQN-11 encodes an unfamiliar protein with a glutamine/asparagine-rich domain that is dispensable for viability and gross morphology. C09G1.2 C09G1.2 Protein of unknown function, has similarity to coiled-coil proteins, has similarity over the N-terminal region to C. elegans D1044.6 C09G1.3 C09G1.3 Protein of unknown function C09G1.4 C09G1.4 Protein with weak similarity to S. cerevisiae SCD5 (Multicopy suppressor of clathrin deficiency) C09G12.1 C09G12.1 Protein containing a homeobox (homeodomain) domain, which are found in transcription factors, has a region of moderate similarity to a region of mouse Arix, which may regulate neurotransmitter identity and sympathetic neuron development homeobox protein; C09G12.1 encodes a paired-like homeodomain protein of the K50 class, which has no obvious function in mass RNAi assays. C09G12.2 C09G12.2 Protein containing a DUF216 domain of unknown function, has high similarity to uncharacterized C. elegans K03D3.1 7TM chemoreceptor, srz family C09G12.3 C09G12.3 Protein containing a DUF216 domain of unknown function, has high similarity to uncharacterized C. elegans C09G12.2 7TM chemoreceptor, srz family C09G12.4 C09G12.4 Protein containing a DUF216 domain of unknown function, has high similarity to uncharacterized C. elegans C09G12.2 C09G12.5 C09G12.5 Protein of unknown function, has strong similarity to uncharacterized C. elegans K03D3.5 C09G12.6 C09G12.6 Protein containing three DUF216 domains of unknown function 7TM chemoreceptor, srz family C09G12.7 C09G12.7 Protein of unknown function, has strong similarity to uncharacterized C. elegans C04F12.2 transposase C09G12.8 C09G12.8 Putative ortholog of C. elegans ced-10 gene product RAS-related protein; ced-10 encodes a GTPase orthologous to human RAC1 (OMIM:602048) that is required for phagocytosis during programmed cell death and for migration of the distal tip cells of the somatic gonad; CED-10 functions in the engulfing cell during apoptosis, and is activated by a complex of CED-2(CrkII) and CED-5(DOCK180) to promote formation of the polarized cell extensions associated with cell corpse engulfment. C09G12.9 C09G12.9 Protein with moderate similarity to tumor susceptibility gene 101 (human TSG101), which acts as a transcriptional corepressor that inhibits ubiquitination and is associated with various malignancies upon gene mutation C09G12.9 is orthologous to the human gene TUMOR SUSCEPTIBILITY GENE 101 (TSG101; OMIM:601387), which when mutated leads to disease. C09G4.1 hyl-1;LAG1-1;lag1Ce-1;C09G4.1 Protein of unknown function, has a region of low similarity to a region of S. cerevisiae Lag1p, which is required with S. cerevisiae Lac1p for ceramide synthesis and ER-to-Golgi transport of GPI-anchored proteins and indirectly affects cell longevity hyl-1 encodes a predicted transmembrane protein that is related to Saccharomyces cerevisiae LAG1 (longevity assurance gene), a protein preferentially expressed in young yeasts; by homology, HYL-1 is predicted to have several possible functions, including regulation of lipid, particularly ceramide, biosynthesis, regulation of lipid transport, and regulation of protein translocation in the endoplasmic reticulum; in C. elegans, however, neither the precise role of HYL-1 in development and/or behavior nor the hyl-1 expression pattern is yet known. C09G4.2 C09G4.2 Protein containing a protein kinase domain, a cyclic nucleotide-binding domain, and a protein kinase C-terminal domain, has moderate similarity to cGMP-dependent protein kinase type 1 (human PRKG1), which relaxes vascular smooth muscle cAMP-dependant protein kinase C09G4.3 cks-1;dom-6;C09G4.3 Member of the highly conserved cyclin-dependent kinase regulatory subunit protein family cyclin-dependent kinase regulatory subunit; A homolog of Cks/Suc1, a highly conserved member of the eukaryotic cell cycle machinery that affects both meiosis and mitosis and has a role in the inactivation of the M-phase promoting factor (MPF) during early embryogenesis. C09G4.5 mes-6;C09G4.4;C09G4.5 WD-40 repeat protein with similarity to human and mouse EED (embryonic ectoderm development protein) and D. melanogaster ESC (extra sexcombs) mes-6 encodes a WD repeat-containing protein that is orthologous to Drosophila Extra sex combs (Esc); as a member of a Polycomb-like chromatin repressive complex with MES-2 and MES-3, MES-6 is required maternally for normal germline development and during larval development, for anteroposterior patterning; during germline development, the MES-2/MES-3/MES-6 complex is believed to be essential for maintaining repression of the X chromosome, and in transgenic animals, the complex is necessary for germline repression of repetitive transgenes; in axial patterning, the MES-2/MES-3/MES-6 complex is required in somatic tissues for maintaining homeotic gene repression, acting upstream of the Hox genes lin-39, mab-5, and egl-5, as well as the egl-5 target gene lin-32; MES-6 expression is detected in the nuclei of all cells during early embryogenesis, in the germline precursors Z2 and Z3 and faintly in some somatic cells during late embryogenesis and the L1 larval stage, widely in later larvae, and in germline and oocyte nuclei in adults; normal MES-6 distribution is dependent upon wild-type activity of MES-2 and MES-3, and likewise, distribution of MES-3 is dependent upon wild-type activity of MES-2 and MES-6. C09G5.1 gbr-4;C09G5.1 Protein containing neurotransmitter-gated ion-channel ligand binding and transmembrane domains, has moderate similarity to glycine receptor subunit alpha 3 (human GLRA3), which is the ligand-binding subunit of neuronal glycine-gated chloride channels gamma-aminobutyric-acid receptor (beta-1 subunit); ggr-1 encodes a predicted member of the GABA/ glycine receptor family of ligand-gated chloride channels that affects thermotaxis; expressed in AIB, PVR, PVQ, AVH, and SMDV neurons and in some motor neurons in the ventral cord, and in the egg-laying muscles. C09G5.2 C09G5.2 Member of the putative diphthamide synthesis protein family, has low similarity to diphtheria toxin resistance protein (S. cerevisiae Dph2p), which is required for diphthamide biosynthesis Diphthamide biosynthesis protein (diptheria resistance protein); C09G5.2 encodes an ortholog of S. cerevisiae DPH2/YKL191W and human DPH2L2 (OMIM:603456); C09G5.2 is a putative protein component of diphtamide synthesis; C09G5.2 has no obvious function in mass RNAi assays. C09G5.3 C09G5.3 Protein containing two collagen triple helix repeats, which are found in some extracellular proteins, and a nematode cuticle collagen N-terminal domain, has a region of high similarity to a region of C. elegans BLI-1 collagen C09G5.4 C09G5.4 Protein containing two collagen triple helix repeats, which are found in some extracellular proteins, and a nematode cuticle collagen N-terminal domain, has a region of high similarity to a region of C. elegans BLI-1 collagen; col-39 encodes a collagen that is individually dispensable for viability and gross morphology in mass RNAi screens; the amino- and carboxyl-terminal cysteine-rich regions of COL-39 are most closely related to those of COL-8, COL-19, and COL-35. C09G5.5 C09G5.5 Protein containing three collagen triple helix repeats, which are found in some extracellular proteins, and a nematode cuticle collagen N-terminal domain, has a region of moderate similarity to a region of C. elegans BLI-1 collagen C09G5.6 bli-1;C09G5.6 Member of the collagen triple helix repeat (20 Copies) protein family collagen; The bli-1 gene encodes an unusual cuticular collagen that is required for proper strut formation within the unique medial layer of the adult cuticle; bli-1 interacts genetically with other cuticular collagens such as bli-2 and rol-1, and may be processed for secretion by BLI-4, a Kex2/subtilisin serine endoproteinase; consistent with its role in adult cuticle formation, bli-1 mRNA is highly expressed only during the L4 larval stage. C09G5.7 C09G5.7 Protein of unknown function, has moderate similarity to uncharacterized C. elegans C54G4.2 C09G5.8 C09G5.8 Putative ortholog of C. elegans C52A11.1 gene product C09G9.1 C09G9.1 Protein of unknown function C09G9.2 C09G9.2 Protein containing three WD domains (WD-40 repeat), which may mediate protein-protein interactions C09G9.3 C09G9.3 Protein containing one C. elegans C-terminal C6 domain, which contain conserved cysteine residues C09G9.4 C09G9.4 Protein containing three pyridoxal-dependent group II decarboxylase conserved domains, which bind pyridoxal-phosphate groups, has weak similarity to dopa decarboxylase (aromatic L-amino acid decarboxylase, mouse Ddc) aromatic-L-amino-acid decarboxylase C09G9.5 C09G9.5 Protein of unknown function C09G9.6 C09G9.6 Protein containing two CCCH-type zinc finger domains, which bind DNA or RNA, has a region of high similarity to a region of C. elegans MEX-1, which is a highly conserved eukaryotic germline protein required for differentiation of some cell lineages Zinc finger protein; The oma-1 gene encodes a zinc finger protein of the TIS11 finger type that is paralogous to OMA-2; while either oma-1 or oma-2 individually have no obvious mutant phenotype, a normal copy of at least one of these genes is required for oocyte maturation. C09G9.7 C09G9.7 One member of a four protein Pax-like gene family, the Npax family, in C. elegans; the protein contains only the N-terminal PAI subdomain of the Paired domain 'Paired box' domain C09H10.1 C09H10.1 Protein of unknown function C09H10.10 C09H10.10 Protein of unknown function C09H10.2 C09H10.2;2L388 Protein with high similarity to ribosomal protein L42 (S. cerevisiae Rpl42bp), which is involved in replication of M1 and M2 double-stranded RNA (dsRNA) viruses, member of the ribosomal L44 family, which are part of the large ribosomal subunit 60S ribosomal protein; rpl-41 encodes a large ribosomal subunit L41 protein; by homology, RPL-41 is predicted to function in protein biosynthesis. C09H10.3 nuo-1;C09H10.3 NADH-ubiquinone oxidoreductase of complex I of the mitochondrial respiratory chain; required for embryogenesis and normal growth, movement, phayrngeal pumping and defecation NADH-ubiquinone oxidoreductase; The nuo-1 gene encodes a mitochondrial NADH-ubiquinone oxidoreductase required for progression through development; nuo-1 is orthologous to the human gene NADH DEHYDROGENASE (UBIQUINONE) FLAVOPROTEIN 1 (NDUFV1; OMIM:161015), which when mutated leads to Leigh syndrome (OMIM:256000). C09H10.4 C09H10.4 Protein of unknown function C09H10.5 C09H10.5 Protein of unknown function, has moderate similarity to uncharacterized C. elegans T25B6.3 C09H10.6 C09H10.6 Protein of unknown function, has moderate similarity to uncharacterized C. elegans C50B6.2 histone binding protein C09H10.7 C09H10.7 Protein of unknown function C09H10.8 C09H10.8 Protein of unknown function C09H10.9 C09H10.9 Protein of unknown function, has weak similarity to uncharacterized C. elegans C14C11.1 C09H5.1 C09H5.1 Protein of unknown function C09H5.2 C09H5.2 Member of the E1-E2 ATPase and haloacid dehalogenase families, contains cation transporting ATPase C-terminal and N-terminal domains, has moderate similarity to H+/K+ transporting ATPase alpha polypeptide (mouse Atp4a), which is a gastric proton pump ATPase C09H5.3 C09H5.3 Member of the 7-transmembrane chemoreceptor family of G protein-coupled receptors (GPCR), has low similarity to C. elegans ODR-10, which is a G protein-coupled receptor involved in odorant response 7TM chemoreceptor, str family C09H5.4 C09H5.4 Member of the 7-transmembrane chemoreceptor family of G protein-coupled receptors (GPCR), has low similarity to C. elegans ODR-10, which is a G protein-coupled receptor involved in odorant response 7TM chemoreceptor, str family C09H5.5 C09H5.5 Member of the 7-transmembrane chemoreceptor family of G protein-coupled receptors (GPCR), has low similarity to C. elegans ODR-10, which is a G protein-coupled receptor involved in odorant response 7TM chemoreceptor, str family C09H5.6 C09H5.6 Member of the 7-transmembrane chemoreceptor family of G protein-coupled receptors (GPCR), has low similarity to C. elegans ODR-10, which is a G protein-coupled receptor involved in odorant response 7TM chemoreceptor, str family C09H5.7 C09H5.7 Protein with high similarity to S. cerevisiae Glc7p, which is a protein serine or threonine phosphatase and required for glucose repression, membrane bilayer mixing, and vesicular trafficking, contains a serine or threonine protein phosphatase domain phophatase C09H5.9 C09H5.9 Member of the 7-transmembrane chemoreceptor family of G protein-coupled receptors (GPCR), has low similarity to C. elegans ODR-10, which is a G protein-coupled receptor involved in odorant response 7TM chemoreceptor, str family C09H6.1 C09H6.1 Protein containing seventeen C2H2 type zinc finger domains, which bind nucleic acids, has a region of weak similarity to a region of restrictive element silencer transcription factor (rat Rest), which is a DNA-binding protein that silences transcription Zinc finger, C2H2 type (11 domains) C09H6.2 lin-10;C09H6.2 Member of PTB, PDZ domain-containing family of proteins; strongly similar over C-terminal half to human amyloid beta (A4) precursor protein-binding proteins (APBA1, APBA2, APBA3); required for determination of vulva cell fate Phosphotyrosine interaction domain (PTB/PID)., PDZ domain (Also known as DHR or GLGF). (2 domains); The lin-10 gene encodes a PDZ and PTB domain-containing protein that is homologous to mammalian Munc interacting proteins (Mint1, OMIM:602414) and is required for polarized protein localization; LIN-10 is required for proper localization of the LET-23 EGF receptor to the basolateral membrane of the vulval precursor cells and for proper postsynaptic localization of GLR-1, an AMPA-type glutamate receptor in interneurons; LIN-10 is detected in the cytoplasm, membrane, and at particularly high levels in the Golgi. C09H6.3 C09H6.3 Protein of unknown function, has weak similarity to uncharacterized human KIAA0892 C10A4.1 C10A4.1 Protein of unknown function, has moderate similarity to uncharacterized C. elegans K09A11.1 transposase HFL1 (D. melanogaster) C10A4.2 C10A4.2 Protein of unknown function C10A4.3 C10A4.3 Protein of unknown function C10A4.4 C10A4.4 Protein of unknown function C10A4.5 C10A4.5 Protein of unknown function C10A4.6 C10A4.6 Protein of unknown function C10A4.7 C10A4.7 Protein of unknown function C10A4.8 C10A4.8 Protein containing three C2H2 type zinc finger domains, which bind nucleic acids, has a region of high similarity to a region of zinc finger protein 85 (human ZNF85), which functions as a transcriptional co-repressor Zinc finger protein C10B5.1 C10B5.1 Protein containing three WD domains (WD-40 repeat), which may mediate protein-protein interactions C10B5.3 C10B5.3 Protein of unknown function C10C5.1 C10C5.1 Protein of unknown function, has moderate similarity to H. sapiens Hs.79077 gene product C10C5.2 C10C5.2 Protein containing an F-box domain, which serve as a link between a target protein and a ubiquitin-conjugating enzyme C10C5.3 C10C5.3 Protein with high similarity to aminoacylase 1 (human ACY1), which catalyzes the hydrolysis of N-alpha-acylated amino acids and may contribute to formation of small cell lung cancer, member of the M20, M25, or M40 peptidase family of zinc metalloproteases aminoacylase-1 C10C5.4 C10C5.4 Protein with high similarity to aminoacylase 1 (human ACY1), which catalyzes the hydrolysis of N-alpha-acylated amino acids and may contribute to formation of small cell lung cancer, member of the M20, M25, or M40 peptidase family of zinc metalloproteases aminoacylase-1 C10C5.5 C10C5.5 Protein with high similarity to aminoacylase 1 (human ACY1), which catalyzes the hydrolysis of N-alpha-acylated amino acids and may contribute to formation of small cell lung cancer, member of the M20, M25, or M40 peptidase family of zinc metalloproteases aminoacylase-1 C10C5.6 C10C5.6 Putative ortholog of S. cerevisiae Yhr186p, an essential protein of unknown function Yeast YHY6 like; daf-15 is required for non-dauer development, at least in some tissues or stages; daf-15(m81) mutants constitutively and irreversibly form abnormal dauer-like larvae (and are thus effectively lethal/sterile); mutants do not form true dauers when exposed to dauer pheromone, yet execute only two molts; daf-15 is uncloned. C10C6.1 kin-4;C10C6.1 Protein containing protein kinase and PDZ, DHR, or GLGF domains, has moderate similarity to a region of mouse Mtssk, which is a microtubule associated testis specific serine/threonine protein kinase that may play a role in spermatid maturation serine/threonine kinase C10C6.2 C10C6.2 Member of the rhodopsin family of G protein-coupled receptors (GPCR), has low similarity to C. elegans NPR-1, which is involved in locomotory behavior G-protein coupled receptor C10C6.3 C10C6.3 Protein of unknown function, has high similarity to uncharacterized C. elegans C15H7.4 C10C6.5 C10C6.5 Member of the ABC transporter family, which are involved in translocation across biological membranes, has low similarity to ATP-binding cassette subfamily G member 2 (human ABCG2), which is a transporter involved in development of multidrug resistance ATP binding transport protein C10C6.6 C10C6.6 Member of the haloacid dehalogenase or epoxide hydrolase family and the E1-E2 (P-type) ATPase family, has moderate similarity to S. cerevisiae Spf1p, which is a putative Ca2+-transporting ATPase involved in toxin resistance E1-E2 ATPase C10E2.1 C10E2.1 Protein of unknown function C10E2.2 C10E2.2 Protein of unknown function This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins. C10E2.3 C10E2.3 Member of the histone deacetylase family, which catalyze removal of acetyl groups from histones, has a region of high similarity to a region of histone deacetylase 4 (human HDAC4), which acts as a corepressor of human MEF2 dependent transcription C10E2.4 C10E2.4 Protein of unknown function C10E2.5 C10E2.5 Protein of unknown function C10E2.6 C10E2.6 Member of the sugar (and other) transporter family, has low similarity to solute carrier family 16 member 4 (human SLC16A4), which is a proton-dependent lactate transport protein sugar transporter C10F3.1 C10F3.1 Protein of unknown function, has weak similarity to human AGC1,a chondroitin sulfate proteoglycan C10F3.2 C10F3.2 Putative retinol dehydrogenase alcohol/ribitol dehydrogenase; dhs-16 encodes a short-chain dehydrogenase predicted to be mitochondrial. C10F3.3 acy-2;C10F3.3 Putative adenylyl cyclase adenylate cyclase; An intragenic deletion of acy-2 is lethal at the first larval stage of development; the terminal phenotype resembles that seen in loss-of-function gsa-1 mutants. C10F3.4 C10F3.4 Protein of unknown function C10F3.5 pcm-1;C10F3.5 L-Isoaspartyl (D-aspartate) O-Methyltransferase L-isoaspartyl/D-aspartyl methyltransferase C10F3.6 C10F3.6 Protein containing a Src homology 3 domain, has a region of moderate similarity to fucosyltransferase 8 (alpha (1,6) fucosyltransferase, human FUT8), which acts in asparagine-linked oligosaccharide synthesis and may be associated with carcinogenesis C10G11.1 C10G11.1 Protein of unknown function, has high similarity to uncharacterized C. elegans C10G11.10 C10G11.10 C10G11.10 Protein of unknown function, has high similarity to uncharacterized C. elegans C10G11.1 C10G11.2 C10G11.2 Member of the 7-transmembrane chemoreceptor family of G protein-coupled receptors (GPCR), has high similarity to uncharacterized C. elegans C10G11.3 7TM chemoreceptor, srh family C10G11.3 C10G11.3 Member of the 7-transmembrane chemoreceptor family of G protein-coupled receptors (GPCR), has high similarity to uncharacterized C. elegans C10G11.2 7TM chemoreceptor, srh family C10G11.4 C10G11.4 Member of the 7-transmembrane chemoreceptor family of G protein-coupled receptors (GPCR), has high similarity to uncharacterized C. elegans C10G11.2 7TM chemoreceptor, srh family C10G11.5 C10G11.5 Protein with moderate similarity to S. cerevisiae Ydr531p, which is a putative pantothenate kinase involved in coenzyme A biosynthesis C10G11.6 C10G11.6 Protein of unknown function C10G11.7 C10G11.7 Protein of unknown function C10G11.8 C10G11.8 Member of the proteasome complex protein family ATPase C10G11.9 C10G11.9 Protein of unknown function, has very strong similarity to uncharacterized C. elegans T27A3.4 C10G6.1 C10G6.1 Protein containing a 3'-5' exonuclease domain, which catalyze the hydrolysis of mismatched or unpaired nucleotides C10G8.1 C10G8.1 Member of the C. elegans Srg family of integral membrane proteins, which may be involved in chemosensation, has low similarity to uncharacterized C. elegans T09D3.5 7TM chemoreceptor, srg family C10G8.2 C10G8.2 Protein containing a kunitz or bovine pancreatic trypsin inhibitor domain, has low similarity to uncharacterized C. elegans K11D12.6 C10G8.3 C10G8.3 Protein containing a kunitz or bovine pancreatic trypsin inhibitor domain, has low similarity to uncharacterized C. elegans K11D12.7 C10G8.4 C10G8.4 Protein containing a trypsin inhibitor-like cysteine rich domain, has moderate similarity to uncharacterized C. elegans Y69H2.5 C10G8.5 C10G8.5 Protein with high similarity to sodium-calcium exchanger 3 (rat Ncx3), which is a sodium-calcium antiporter, member of the sodium or calcium exchanger protein family of membrane transporters, which regulate intracellular Ca2+ concentrations sodium/calcium exchanger protein 1 C10G8.6 ceh-34;C10G8.6 Protein with high similarity to sine oculis homeobox (Drosophila) homolog 1 (human SIX1), which is a putative transcription factor that plays a role in cell cycle checkpoint, contains a homeobox (homeodomain) domain homeobox protein; ceh-34 encodes a homeodomain protein, homologous to human SIX2 (OMIM:604994), that is expressed very weakly in the pharynxes of late embryos and early larvae; it has no known function. C10G8.7 ceh-33;C10G8.7 Protein containing a homeobox (homeodomain) domain, has a region of high similarity to a region of sine oculis homeobox (Drosophila) homolog 1 (human SIX1), which is a putative transcription factor that plays a role in cell cycle checkpoint a homeodomain transcription factor of the six/sine oculis (so) gene family; affects gonad formation, and is expressed in the pharynx. C10G8.8 C10G8.8 Protein of unknown function C10H11.1 C10H11.1 Protein containing a villin headpiece domain, which bind F-actin and are required for F-actin bundling and actin reorganization, has low similarity to a region of supervillin (human SVIL), which links filamentous actin with the plasma membrane C10H11.10 C10H11.10 Putative ortholog of C. elegans M04F3.3 gene product C10H11.2 C10H11.2 Member of the transposase family, which are required for excising and inserting mobile genetic elements, has very strong similarity to uncharacterized C. elegans ZK546.8 C10H11.3 C10H11.3 Protein containing two UDP-glucoronosyl and UDP-glucosyl transferase domains, has weak similarity to UDP glycosyltransferase 1 family polypeptide A1 (human UGT1A), which acts in bilirubin conjugation and has a role in Gilbert and Crigler-Najjar syndromes C10H11.4 C10H11.4 Protein containing two UDP-glucoronosyl and UDP-glucosyl transferase domains, has low similarity to UDP-glycosyltransferase 1 A9 (human UGT1A9), which converts hydrophobic xenobiotic and endobiotic compounds to hydrophilic compounds for removal from cell C10H11.5 C10H11.5 Protein containing a UDP-glucoronosyl and UDP-glucosyl transferase domain, has low similarity to UDP glycosyltransferase 1 A3 (human UGT1A3), which converts hydrophobic xenobiotic and endobiotic compounds to hydrophilic compounds for removal from cell C10H11.6 C10H11.6 Protein containing two UDP-glucoronosyl and UDP-glucosyl transferase domains, has low similarity to UDP glycosyltransferase 1 family polypeptide A1 (human UGT1A), which acts in bilirubin conjugation and has a role in Gilbert and Crigler-Najjar syndromes C10H11.7 C10H11.7 Protein containing a major sperm protein (MSP) domain, which are involved in sperm motility C10H11.8 C10H11.8 Protein containing six WD domains (WD-40 repeat), which may mediate protein-protein interactions, has low similarity to S. cerevisiae Lst8p, which is a protein required for transport of permeases from the Golgi to the plasma membrane C10H11.9 let-502;C10H11.9 Serine/threonine protein kinase required for embryonic elongation; putative ortholog of ROCK2 and ROCK1 rho-associated protein kinases, has strong similarity to D. melanogaster GEK protein, which is a putative effector for CDC42 function Rho-associated kinase; let-502 encodes Rho-binding Ser/Thr kinase orthologous to human myotonic dystrophy kinase (DM-kinase), and is required for early embryonic cleavages, embryonic elongation, migration of hypodermal P cells to a ventral position, normal spermathecal contraction, and fertility; LET-502 is required for hypodermal cells to properly change their shape, and is expressed in those cells, during embryonic elongation; let-502 mutations are suppressed by mel-11 mutations, and the pattern of LET-502 expression in the embryonic epidermis and the spermatheca is opposite to that of MEL-11, indicating that LET-502 and MEL-11 have opposing functions (presumably tissue contraction and relaxation); MEL-11 requires LET-502 (along with the nonmuscle myosin NMY-1) for proper localization. C11D2.1 C11D2.1 Protein of unknown function, has moderate similarity to C. elegans D2024.9 C11D2.2 C11D2.2 Protein with high similarity to C. elegans ASP-6, which is an aspartyl protease involved in protein degradation, member of the aspartyl (acid) protease family, which include pepsins, cathepsins and renins protease C11D2.3 C11D2.3 Protein of unknown function C11D2.4 C11D2.4 Protein containing a PUA (pseudouridine synthase and archaeosine transglycosylase) domain, which may bind RNA, has a region of high similarity to human MCT-1, which is involved in cell cycle regulation and may be associated with T-cell malignancy C11D2.5 C11D2.5 Protein of unknown function, has high similarity to uncharacterized C. elegans F17C8.6 C11D2.6 C11D2.6 Member of the ion transport family, which include calcium, sodium, and potassium channels, has weak similarity to calcium channel alpha 1S subunit (human CACNA1S), which is involved in coupling of excitation and contraction in muscle C11D9.1 C11D9.1 Protein containing a RhoGEF (GTPase exchange factor) domain and a PDZ, DHR, or GLGF domain, which are found in signaling proteins, has a region of low similarity to a region of mouse Tiam2, which is a Rac1-specific guanyl-nucleotide exchange factor C11E4.1 C11E4.1 Member of the glutathione peroxidase family, has moderate similarity to glutathione peroxidase 5 (mouse Gpx5), which is a selenium-independent glutathione peroxidase that protects epididymis and perhaps sperm membranes from peroxidative damage glutathione peroxidase C11E4.2 C11E4.2 Member of the glutathione peroxidase family, has moderate similarity to plasma glutathione peroxidase (human GPX3), which reduces lipid hydroperoxide and hydrogen peroxide in plasma and catalyzes the reduction of tertiary butyl hydroperoxide glutathione peroxidase C11E4.3 C11E4.3 Member of the amiloride-sensitive sodium channel family, which are involved in sodium reabsorption C11E4.4 C11E4.4 Member of the amiloride-sensitive sodium channel family, which are involved in sodium reabsorption C11E4.6 C11E4.6 Protein containing six ankyrin (Ank) repeats and a SAM (sterile alpha motif) domain, which may mediate protein-protein interactions, has a region of low similarity to a region of ankyrin (rat Ank3), which links membrane proteins to the cytoskeleton ankyrin repeats C11E4.7 C11E4.7 Protein of unknown function C11G10.1 C11G10.1 Protein of unknown function C11G10.2 C11G10.2 Protein of unknown function C11G6.1 C11G6.1 Protein of unknown function, has weak similarity to C. elegans Y54E2A.8 taf-3 encodes the C. elegans ortholog of mammalian TAF3(TAFII140), a component of the RNA polymerase II TFIID transcription complex; TAF-3 contains a histone fold-like domain in its N-terminus and by homology, is predicted to function in transcriptional regulation; however, as loss of taf-3 activity via large-scale RNAi screens does not result in any obvious abnormalities, the precise role of taf-3 in C. elegans development and/or behavior is not yet known. C11G6.2 C11G6.2 Protein of unknown function, has low similarity to a region of S. cerevisiae Rrm3p, which is a DNA helicase that promotes replication fork progression through the ribosomal DNA helicase like C11G6.3 C11G6.3 Protein containing a putative PHD-type zinc fingerdomain, has weak similarity to human protein kinase STK10 PHD-finger. C11G6.4 nhr-28;C11G6.4 Member of the nuclear hormone receptor/Zinc finger protein family nuclear hormone receptor, nhr-28 C11H1.1 C11H1.1 Protein containing a type 1 thrombospondin domain C11H1.2 C11H1.2 Protein of unknown function, has high similarity to uncharacterized C. elegans Y75B8A.16 C11H1.3 C11H1.3 Protein containing a C3HC4 type (RING) zinc finger, which may mediate protein-protein interactions, has low similarity to uncharacterized human KIAA0544 Zinc finger, C3HC4 type (RING finger) C11H1.4 C11H1.4 Putative ortholog of C. elegans C11H1.6 gene product peroxisome biosynthesis protein like; prx-1 encodes a predicted peroxin, a subfamily 2 member of the AAA (ATPases Associated with diverse cellular Activities) family that affects growth in one large-scale RNAi screen; expressed in intestinal cells throughout development. C11H1.5 C11H1.5 Protein of unknown function, has weak similarity to uncharacterized C. elegans F20G2.3 C11H1.6 C11H1.6 Member of the proteasome complex protein family C11H1.7 C11H1.7 Protein of unknown function C12C8.1 C12C8.1 Protein with high similarity to heat shock 70kD protein 8 (human HSPA8), which is elevated in the hearts of patients with hypertrophic cardiomyopathy, member of the Hsp70 family, which are stress-induced protein chaperones heat shock protein 70; hsp-70 encodes a member of the hsp70 family. C12C8.2 C12C8.2 Member of the cysteine-methionine metabolism pyridoxal-phosphate-dependent enzyme family, has moderate similarity to cystathionase (human CTH), which is a pyridoxal phosphate-dependent enzyme that acts in the cysteine metabolic pathway L-methionine-alpha-deamino-gamma-mercaptomethane lyase C12C8.3 lin-41;C12C8.3 RING finger-containing protein that acts in the heterochronic patterning pathway The lin-41 gene encodes a novel RBCC (Ring finger-B box-Coiled coil) protein that is a member of the NHL (NCL-1, HT2A, and LIN-41) family of proteins and is required for the proper temporal control of specific postembryonic cell fates; lin-41 translation is negatively regulated during L4 and adult stages by let-7, a small temporally regulated RNA (stRNA) that is complementary to two sites in the lin-41 3'UTR; LIN-41 is a widely expressed cytoplasmic protein and negatively regulates post-transcriptional expression of LIN-29, a transcription factor required for adult cell fates. C12D12.1 C12D12.1 Protein of unknown function, has a region of low similarity to a region of nascent-polypeptide-associated complex alpha subunit (mouse Naca), which binds JUN, enhances JUN-mediated transcription, and functions in myogenesis C12D12.2 glt-2;Ceglut-2;C12D12.2 Putative glutamate transporter excitatory amino acid transporter; glt-1 encodes a predicted plasma membrane glutamate transporter that is functional when expressed in Xenopus oocytes; expressed in the M3 pharyngeal neuron, the male tail, some anterior hypodermal cells, and in cells in the terminal bulb of the pharynx. C12D12.3 C12D12.3 Protein of unknown function C12D12.4 C12D12.4 Protein of unknown function C12D12.5 C12D12.5 Protein containing a high mobility group box (HMG 1 or 2) family domain, has a region of high similarity to a region of SRY (sex determining region Y)-box 20 (human SOX20), which may regulate male gonad development C12D12.6 C12D12.6 Member of the reverse transcriptase protein family, which are RNA-dependent DNA polymerases, has high similarity to uncharacterized C. elegans T05F1.12 C12D5.10 C12D5.10 Protein of unknown function, has low similarity to uncharacterized C. elegans C12D5.9 C12D5.2 C12D5.2 Protein containing a nuclear hormone receptor C4-type zinc finger domain, which bind DNA and may be involved in regulation of transcription, and a nuclear hormone receptor ligand-binding domain, has weak similarity to pregnane X receptor (mouse Nr1i2) zinc finger protein C12D5.3 C12D5.3 Protein of unknown function, has high similarity to uncharacterized C. elegans B0294.1 C12D5.4 C12D5.4 Protein of unknown function, has low similarity to uncharacterized C. elegans B0294.1 C12D5.5 C12D5.5 Protein of unknown function, has moderate similarity to uncharacterized C. elegans B0294.1 C12D5.7 C12D5.7 Putative cytochrome P450 cytochrome P450 C12D5.8 nhr-94;C12D5.8 Member of the C. elegans Sre G protein-coupled chemoreceptor family, contains one nuclear hormone receptor C4-type zinc finger and one nuclear hormone receptor ligand-binding domain, has a region of low similarity to a region of C. elegans NHR-58 C12D5.9 C12D5.9 Protein of unknown function, has moderate similarity to uncharacterized C. elegans R13D7.2 C12D8.1 C12D8.1 Protein containing eight KH domains, which may bind RNA, has moderate similarity to KH-type splicing regulatory protein (FUSE-binding protein 2, human KHSRP), which is a pre-mRNA splicing factor and putative transcription factor RNA binding protein; C12D8.1 encodes two alternative proteins (through alternative splicing), that belong to an ancient family of single-stranded nucleic acid-binding proteins, and that are predicted to regulate gene expression through binding either mRNA or (locally) single-stranded DNA; they is most likely to specifically bind one or more discrete mRNAs and regulate their spatial localization or alternative splicing. C12D8.10 C12D8.10 Putative ortholog of C. elegans akt-2 gene product PH (pleckstrin homology) domain, Protein kinase C terminal domain; akt-1 encodes an ortholog of serine/threonine kinase Akt/PKB; akt-1 genetically interacts with the insulin signaling pathway and is widely expressed; two alleles of akt-1 (sa573 and sa700) have a Daf-c mutant phenotype at 27 degrees C (Hid phenotype). C12D8.11 rop-1;C12D8.11 Ro ribonucleoprotein similar to human and Xenopus Ro60 ROP-1 ribonucleoprotein RO autoantigen C12D8.12 C12D8.12 Member of the 7-transmembrane chemoreceptor family of G protein-coupled receptors (GPCR), has moderate similarity to uncharacterized C. elegans R08C7.7 C12D8.4 C12D8.4 Member of the transthyretin-like family, has high similarity to uncharacterized C. elegans R90.2 Transthyretin-like family C12D8.5 C12D8.5 Protein containing a Rieske iron-sulfur protein 2Fe-2S domain, which bind ubiquinol or plastoquinol anion and transfer electrons to the 2Fe-2S cluster 3-chlorobenzoate-3,4-dioxygenase like C12D8.6 C12D8.6 Protein of unknown function C12D8.8 C12D8.8 Protein containing two collagen triple helix repeats, which are found in some extracellular proteins, and a nematode cuticle collagen N-terminal domain, has low similarity to C. elegans ROL-6 collagen C12D8.9 C12D8.9 Protein of unknown function C13A10.1 C13A10.1 Protein of unknown function C13A10.2 C13A10.2 Protein of unknown function C13A10.3 C13A10.3 Protein containing a Src homology 3 (SH3) domain, has a region of moderate similarity to a region of protein kinase mitogen-activated 8 interacting protein (JNK-interacting protein 1, mouse Prkm8ip), which is a regulator of the JNK signaling pathway C13A2.1 C13A2.1 Protein containing two DUF23 domains of unknown function, has high similarity to uncharacterized C. elegans F07G11.4 C13A2.10 C13A2.10 Member of the domain of unknown function DUF13 family, has strong similarity to uncharacterized C. elegans F07G11.2 C13A2.11 C13A2.11 Protein containing a DUF23 domain of unknown function C13A2.2 C13A2.2 Protein containing a DUF138 domain of unknown function C13A2.3 C13A2.3 Putative ortholog of C. elegans C13A2.7 gene product C13A2.4 C13A2.4 Member of the domain of unknown function DUF13 family, has high similarity to uncharacterized C. elegans C13A2.10 C13A2.5 C13A2.5 Protein containing two DUF23 domains of unknown function, has high similarity to uncharacterized C. elegans C27A7.2 C13A2.6 C13A2.6 Protein containing a DUF23 domain of unknown function, has high similarity to uncharacterized C. elegans K08D9.6 C13A2.7 C13A2.7 Protein of unknown function, has low similarity to uncharacterized C. elegans W08G11.1 C13A2.9 C13A2.9 Member of the domain of unknown function DUF13 family, has strong similarity to uncharacterized C. elegans F07G11.1 C13B4.1 C13B4.1 Protein with strong similarity to C. elegans dao-2 gene product C13B4.2 tgt-1;tgt;C13B4.2 Member of the ubiquitin family and of the ubiquitin carboxyl-terminal hydrolase family 2, contains a ubiquitin carboxyl-terminal hydrolases family 2 domain, has moderate similarity to ubiquitin specific protease 14 (human USP14) Queuine trna-ribosyltransferase; usp-14 encodes a homolog of ubiquitin-specific protease 14 (Usp14), a highly conserved thiol protease that hydrolyzes the peptide bond at the C-terminal glycine of ubiquitin (OMIM:607274, mutations are associated with synaptic defects in ataxia mice); by homology, USP-14 is predicted to function in ubiquitin-mediated protein degradation, or regulation of protein localization or activity; as loss of USP-14 function via RNA-mediated interference (RNAi) does not result in any abnormalities, the precise role of USP-14 in C. elegans development and/or behavior is not yet known. C13B7.6 C13B7.6 Putative ortholog of C. elegans Y45G12C.I gene product C13B7.A C13B7.5;C13B7.A Member of the 7-transmembrane chemoreceptor family of G-protein coupled receptors (GPCR), has low similarity to C. elegans ODR-10, which is a G protein-coupled receptor involved in odorant response C13B7.B C13B7.4;C13B7.B Putative ortholog of C. elegans Y45G12C.9 gene product C13B7.C srd-60;C13B7.3;C13B7.C Protein of unknown function, putative paralog of C. elegans Y45G12C.I C13B7.D C13B7.2;C13B7.D Member of the 7-transmembrane chemoreceptor family of G-protein coupled receptors (GPCR), has low similarity to C. elegans ODR-10, which is a G protein-coupled receptor involved in odorant response C13B9.2 C13B9.2 Protein of unknown function C13B9.3 C13B9.3 Member of the clathrin adaptor complexes medium chain family, which are involved in transport of clathrin-coated vesicles, has low similarity to coatomer (COPI) complex delta chain (delta-COP) of secretory pathway vesicles (S. cerevisiae Ret2p) C13B9.3 encodes a delta subunit of the coatomer (COPI) complex; in mass RNAi assays, C13B9.3 is required for fertility and general health. C13B9.4 C13B9.4 Member of the secretin family of G protein-coupled receptors, contains a hormone receptor domain, has weak similarity to glucagon receptor (human GCGR), which regulates cAMP and calcium levels, glucose production, and insulin secretion C13B9.4 is orthologous to the human gene CALCITONIN RECEPTOR (CALCR; OMIM:114131), which when mutated leads to disease. C13C12.1 cal-1;C13C12.1 Protein containing four EF hand domains, which are found in signaling, buffering or transport proteins, has a region of high similarity to calmodulin 1 (phosphorylase kinase delta, rat Calm1), which is a neuronal cell protein that binds calcium calmodulin like protein; a homolog of calmodulin. C13C12.2 C13C12.2 Protein of unknown function C13C4.1 C13C4.1 Protein containing one nuclear hormone receptor C4-type zinc finger domain and one nuclear hormone receptor ligand-binding domain, has weak similarity to estrogen related receptor gamma (mouse Esrrg), which activates ligand-independent transcription Ligand-binding domain of nuclear hormone receptors, Zinc finger, C4 type (two domains) C13C4.2 C13C4.2 Protein containing a nuclear hormone receptor ligand-binding domain and a nuclear hormone receptor C4-type zinc finger, which may be involved in transcription regulation, has weak similarity to estrogen related receptor gamma (mouse Esrrg) Ligand-binding domain of nuclear hormone receptors, Zinc finger, C4 type (two domains) C13C4.3 C13C4.3 Protein containing a nuclear hormone receptor ligand-binding domain and a nuclear hormone receptor C4-type zinc finger, which bind DNA and may be involved in transcription regulation, has weak similarity to human NR1I2 Ligand-binding domain of nuclear hormone receptors, Zinc finger, C4 type (two domains) C13C4.4 C13C4.4 Member of the haloacid dehalogenase or epoxide hydrolase family, has moderate similarity to uncharacterized human LHPP C13C4.5 C13C4.5 Member of the sugar (and other) transporter family, has a region of weak similarity to a region of S. cerevisiae Hxt2p, which is a high-affinity hexose transporter sugar transporter C13C4.6 C13C4.6 Member of an uncharacterized protein family C13D9.1 C13D9.1 Protein of unknown function, has moderate similarity to uncharacterized C. elegans C13D9.2 C13D9.2 C13D9.2 Protein of unknown function, moderate similarity to uncharacterized C. elegans C13D9.1 C13D9.3 C13D9.3 Protein of unknown function, has high similarity to uncharacterized C. elegans T01G5.4 C13D9.4 C13D9.4 Protein of unknown function, has moderate similarity to uncharcterized C. elegans C13D9.5 7TM chemoreceptor, srsx family C13D9.5 C13D9.5 Protein of unknown function, has high similarity to uncharacterized C. elegans C13D9.6 7TM chemoreceptor, srsx family C13D9.6 C13D9.6 Protein of unknown function, has high similarity to uncharacterized C. elegans C13D9.5 7TM chemoreceptor, srsx family C13D9.7 C13D9.7 Member of the sodium or calcium exchanger protein family of membrane transporters, which regulate intracellular Ca2+ concentrations, has weak similarity to potassium-dependent sodium-calcium exchanger 2 (rat Nckx2), which is a calcium:sodium antiporter C13D9.8 C13D9.8 Member of the sodium or calcium exchanger protein family of membrane transporters, which regulate intracellular Ca2+ concentrations, has weak similarity to potassium-dependent sodium-calcium exchanger 2 (rat Nckx2), which is a calcium:sodium antiporter C13D9.9 C13D9.9 Protein containing two UDP-glucoronosyl and UDP-glucosyl transferase domains, has weak similarity to androsterone UDP-glucuronosyltransferase (rat Ugt2b2), which is a 3-hydroxyandrogen UDP-glucuronosyltransferase acting in androgen metabolism UDP-glucuronosyltransferase C13E3.1 C13E3.1 Protein of unknown function C13F10.1 C13F10.1 Protein of unknown function C13F10.2 C13F10.2 Protein of unknown function, has moderate similarity to H. sapiens Hs.108847 gene product C13F10.4 C13F10.4 Protein of unknown function, has moderate similarity to uncharacterized human KIAA1414 C13F10.5 C13F10.5 Protein of unknown function C13F10.6 C13F10.6 Protein of unknown function C13F10.7 C13F10.7 Protein containing a zinc knuckle domain, which can bind eukaryotic RNA or DNA C13G3.1 C13G3.1 Protein of unknown function C13G3.2 hot-6;C13G3.2 Ly-6-related protein C13G3.3 C13G3.3 Protein with high similarity to mouse Ppp2r5c, which is a regulatory subunit of protein phosphatase 2A, member of the protein phosphatase 2A regulatory B subunit (B56) family proteion phosphatase C13G5.1 ceh-16;C13G5.1 Homeodomain transcription factor, has similarity over 165 amino acids to D. melanogaster EN (engrailed) homeodomain transcription factor Engrailed homeotic protein; ceh-16 encodes a protein that contains a homeobox domain. C13G5.2 C13G5.2 Putative ortholog of C. elegans C03B1.8 gene product C14A11.2 C14A11.2 Protein with moderate similarity to C. elegans ZC21.1 gene product C14A11.3 C14A11.3 Protein containing a RhoGEF (GTPase exchange factor) domain and a pleckstrin homology (PH) domain, which mediate protein-protein and protein-lipid interactions, has low similarity to MCF.2 cell line derived transforming sequence (human MCF2) guanine-nucleotide releasing factor C14A11.4 C14A11.4 Protein of unknown function, has weak similarity in the N-terminus to human KIAA0362 protein (Hs.25515) C14A11.5 C14A11.5 Protein of unknown function C14A11.6 C14A11.6 Protein of unknown function C14A11.7 C14A11.7 Member of the Ras superfamily of GTP binding proteins, has a region of moderate similarity to a region of RAS dexamethasone induced 1 (mouse Rasd1), which is a small GTPase and nucleotide exchange factor involved in NO mediated signal transduction RAS-related protein C14A4.1 C14A4.1 Protein containing two phycobilisome (PBS) lyase HEAT-like repeats, has high similarity to uncharacterized human MGC4293 C14A4.10 taf-6;C14A4.10 Member of the transcription initiation factor IID 18kD subunit family, has a region of moderate similarity to TBP-associated factor RNA polymerase II K 18 (human TAF13), which forms a heterodimer with human TAF11 in the TFIID complex FUN81 protein; taf-13 encodes a predicted member of the transcription initiation factor IID, 18kDa subunit family with similarity to Drosophila Taf13. C14A4.11 C14A4.11 Protein with similarity to human apoptosis-related protein TFAR15 (Hs.28866) C14A4.12 C14A4.12 Protein of unknown function C14A4.13 C14A4.13 Protein containing a protein kinase domain, has low similarity to S. pombe Hhp2p, which is a casein kinase I homolog serine/threonine kinase C14A4.14 C14A4.14 Protein with moderate similarity to D. melanogaster CG12261 (CG12261 gene product) C14A4.2 dap-3;C14A4.2 Similar to human DAP3, death associated protein 3, which is involved in resistance to ionizing radiation dap-3 is an ortholog of mammalian death-associated protein 3 (DAP3), a mitochondrial ribosomal protein that promotes apoptosis. C14A4.3 C14A4.3 Protein with low similarity to S. cerevisiae Alg9p, which is a mannosyltransferase involved in N-glycosylation that catalyzes the transfer of mannose from Dol-P-Man to lipid-linked oligosaccharides C14A4.4 C14A4.4 Protein containing a helicase and RNase D C-terminal (HRDC) domain and a 3'-5' exonuclease domain, has low similarity to S. cerevisiae Rrp6p, which is involved in 5.8S ribosomal RNA 3'end processing autoantigen PM-SCL; crn-3 encodes a cell death-related nuclease, homologous to the 100 kDa polymyositis/scleroderma autoantigen (PM/Scl-100), that is required for normal levels of DNA degradation during apoptosis; PM/Scl-100 is a ribonuclease component of the multiexonuclease exosome complex, which processes or degrades several types of RNAs in yeast; crn-3(RNAi) animals show retarded growth and a low penetrance of embryonic lethality; CRN-3 promotes both DNA degradation and cell corpse engulfment, in a partially redundant pathway that includes CRN-2 but is parallel to CPS-6; CRN-3 is predicted to be mitochondrial. C14A4.5 C14A4.5 Member of the RNase PH family of 3' exoribonucleases, which are involved in RNA processing, has low similarity to uncharacterized human RRP46 Prokaryotic ribonuclease PH C14A4.6 C14A4.6 Protein of unknown function, has weak similarity to C. elegans C14A4.7 C14A4.7 C14A4.7 Protein of unknown function, has weak similarity to C. elegans C14A4.6 C14A4.8 C14A4.8 Protein of unknown function C14A4.9 C14A4.9 Protein of unknown function C14A6.1 C14A6.1 Member of the C-type lectin family, has similarity to human lymphocyte antigen LY75, has similarity to D. melanogaster selectin FW (furrowed) Lectin C-type domain short and long forms (2 domains) C14A6.2 C14A6.2 Protein with similarity to human and D. melanogaster sodium-dependent inorganic phosphate cotransporters C14A6.3 C14A6.3 Protein containing a WSN domain of unknown function C14A6.4 C14A6.4 Member of the transposase family, which are required for excising and inserting mobile genetic elements, has very strong similarity to uncharacterized C. elegans Y95B8A.3 transposase C14A6.5 C14A6.5 Protein with strong similarity to C. elegans W04E12.4 gene product C14A6.6 C14A6.6 Protein of unknown function, has high similarity to uncharacterized C. elegans W04E12.4 C14A6.7 C14A6.7 Protein of unknown function C14A6.8 C14A6.8 Protein of unknown function, has high similarity to uncharacterized C. elegans Y71G12B.3 C14B1.1 pdi-1;C14B1.1 Protein disulfide isomerase, beta subunit of prolyl 4-hydroxylase protein disulfide isomerase; This gene encodes a protein predicted by Eisenberg and coworkers, with 52% accuracy, to be mitochondrial. C14B1.10 C14B1.10 Member of the 2-oxoglutarate (2OG) and Fe(II)-dependent oxygenase family C14B1.2 C14B1.2 Protein of unknown function C14B1.3 C14B1.3 Protein containing a major sperm protein (MSP) domain, which are involved in sperm motility, has weak similarity to uncharacterized F-box only protein 6 (human FBXO6), which is a putative subunit of the SCF ubiquitin ligase complex This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins. C14B1.4 C14B1.4 Protein containing six WD domains (WD-40 repeat), which may mediate protein-protein interactions, has low similarity to platelet-activating factor acetylhydrolase beta subunit (PAF-AH beta, rat Pafah1b1), which inactivates platelet-activating factor guanine nucleotide binding protein C14B1.5 C14B1.5 Member of the Yil103p-like protein family diptheria toxin resistance protein; C14B1.5 encodes an ortholog of S. cerevisiae YIL103 and human DPH2L1/OVCA1 (OMIM:603527, deleted or downregulated in ovarian tumors); C14B1.5 is paralogous to S. cerevisiae DPH2/YKL191W, a protein component of diphtamide synthesis; C14B1.5 has no obvious function in mass RNAi assays. C14B1.6 C14B1.6 Protein of unknown function C14B1.7 C14B1.7 Protein containing a piwi domain and a PAZ (Piwi, Argonaut and Zwille) domain, which may mediate protein-protein interactions, has a region of weak similarity to a region of C. elegans ALG-1, which is involved in the production of LIN-4 small temporal RNA C14B1.8 C14B1.8 Protein of unknown function C14B1.9 C14B1.9 Protein of unknown function C14B4.1 C14B4.1 Protein with strong similarity to C. elegans Y116F11.N gene product C14B4.2 C14B4.2 Putative ortholog of C. elegans Y116F11.N gene product C14B9.2 C14B9.2 Protein with high similarity to protein disulfide isomerase related protein (rat Erp70), which catalyzes the formation and isomerization of disulfide bonds in protein folding, member of the thioredoxin family erp72; This gene encodes a protein predicted by Eisenberg and coworkers, with 52% accuracy, to be mitochondrial. C14B9.3 C14B9.3 Protein of unknown function, has high similarity to uncharacterized C. elegans F36H9.5 C14B9.6 C14B9.6 Protein containing two Myb-like DNA-binding domains, has a region of weak similarity to a region of nuclear receptor corepressor 2 (human NCOR2), which is a nuclear receptor and transcription factor corepressor and is associated with myeloid leukemia gei-8 encodes a novel protein highly similar to C. briggsae BP:CBP04038 that contains a glutamine/asparagine (Q/N)-rich ('prion') domain (by the algorithm of Michelitsch and Weissman) and two myb-like DNA-binding domains; interacts with GEX-3 in yeast two-hybrid assays. C14B9.7 C14B9.7 Member of the ribosomal protein L21 protein family Ribosomal protein L21; rpl-21 encodes a large ribosomal subunit L21 protein; by homology, RPL-21 is predicted to function in protein biosynthesis; in C. elegans, RPL-21 activity is required for embryonic and germline development. C14B9.8 C14B9.8 Protein with moderate similarity to liver phosphorylase kinase alpha 2 (human PHKA2), which is the alpha subunit of liver phosphorylase kinase and a regulatory enzyme involved in glycogen breakdown Phosphorylase kinase; C14B9.8 is orthologous to the human gene PHOSPHORYLASE KINASE, LIVER, ALPHA-2 SUBUNIT (PHKA2; OMIM:306000), which when mutated leads to liver glycogenosis. C14C10.1 C14C10.1 Member of the mitochondrial carrier protein family of membrane transporters, has moderate similarity to S. cerevisiae Mir1p, which is a phosphate transporter of the mitochondrial carrier (MCF) family mitochondrial carrier protein C14C10.2 C14C10.2 Protein of unknown function, has moderate similarity to C. elegans C56A3.2 Transthyretin-like family C14C10.3 C14C10.3 Protein of unknown function C14C10.4 C14C10.4 Protein of unknown function C14C10.5 C14C10.5 Protein of unknown function, has low similarity to uncharacterized human KIAA0077 Human mRNA (KIAA0077) product like C14C10.6 C14C10.6 Protein of unknown function C14C10.7 C14C10.7 Protein with strong similarity to C. elegans C56A3.2 gene product C14C11.1 C14C11.1 Protein of unknown function, has very strong similarity to uncharacterized C. elegans ZC317.6 C14C11.2 C14C11.2 Protein of unknown function, has very strong similarity to uncharacterized C. elegans ZC317.7 C14C11.3 C14C11.3 Protein of unknown function, has low similarity to uncharacterized C. elegans Y70D2A.2 C14C11.4 C14C11.4 Protein of unknown function, has low similarity to uncharacterized C. elegans H20E11.1 C14C11.5 C14C11.5 Protein of unknown function, has high similarity to uncharacterized C. elegans W05B10.5 7TM chemoreceptor, srx family C14C11.6 mut-14;C14C11.6 Member of the RNA helicase, DEAD-box protein family involved in RNA interference and gene silencing by antisense RNAs helicase; mut-14 mutants exhibit germline transposon activation, a deficient response to RNAi, resistance to co-suppression, and transgene desilencing. C14C11.7 C14C11.7 Protein of unknown function C14C11.8 C14C11.8 Protein containing 18 uncharacterized DUF139 cysteine repeat domains, has low similarity to uncharacterized C. elegans F07H5.8 The protein product of this gene is predicted to contain a glutamine/asparagine (Q/N)-rich ('prion') domain, by the algorithm of Michelitsch and Weissman (as of the WS77 release of WormBase, i.e., in wormpep77). C14C6.1 C14C6.1 Protein of unknown function, has high similarity to uncharacterized C. elegans F07G11.8 7TM chemoreceptor, srx family C14C6.10 C14C6.10 Member of the 7-transmembrane chemoreceptor family of G protein-coupled receptors (GPCR), has high similarity to uncharacterized C. elegans SRI-74 7TM chemoreceptor, sri family C14C6.12 C14C6.12 Protein containing a DUF19 domain of unknown function, which contain twelve conserved cysteines, has low similarity to uncharacterized C. elegans C03G6.5 C14C6.13 C14C6.13 Protein of unknown function C14C6.2 C14C6.2 Protein of unknown function, has high similarity to uncharacterized C. elegans C14C6.5 C14C6.3 C14C6.3 Member of the glycosyl transferase family 11, which hydrolyze the glycosidic bond between two or more carbohydrates, has high similarity to uncharacterized C. elegans K06H6.6 C14C6.4 C14C6.4 Protein containing a nuclear hormone receptor ligand binding domain and a nuclear hormone receptor C-4 type zinc finger domain, has weak similarity to C. elegans NHR-80, which is required for embryogenesis zinc finger protein C14C6.5 C14C6.5 Protein of unknown function, has high similarity to uncharacterized C. elegans C14C6.2 C14C6.6 C14C6.6 Protein containing a DUF138 domain of unknown function, has high similarity to uncharacterized C. elegans ZK488.5 C14C6.7 C14C6.7 Protein containing a DUF138 domain of unknown function, has high similarity to uncharacterized C. elegans ZK488.5 C14C6.8 C14C6.8 Protein containing a DUF138 domain of unknown function, has strong similarity to uncharacterized C. elegans K06H6.4 C14C6.9 C14C6.9 Protein of unknown function, has high similarity to an uncharacterized C. elegans F07G11.8 7TM chemoreceptor, srx family C14E2.1 C14E2.1 Protein of unknown function C14E2.2 C14E2.2 Protein containing an aminotransferase class I and II domain, has high similarity to a region of soluble glutamate-oxaloacetate transaminase (cytosolic aspartate aminotransferase, human GOT1), which acts in the transfer of the amino group from aspartate aspartate aminotransferase C14E2.3 C14E2.3 Protein of unknown function C14E2.4 C14E2.4 Has similarity over the middle region to human proline 4-hydroxylase alpha subunits P4HA2 and P4HA1; has strong similarity to C. elegans Y43F8B.4 C14E2.5 C14E2.5 Protein of unknown function C14E2.6 C14E2.6 Member of the lipase class 3 family, which are a subset of lipolytic enzymes that hydrolyze ester linkages of triglycerides triacylgycerol lipase C14F11.1 C14F11.1 Protein with high similarity to mitochondrial aspartate aminotransferase (glutamic oxaloacetic transaminase, plasma membrane fatty acid binding protein, human GOT2), contains an aminotransferase class I and II domain Aspartate aminotransferase C14F11.2 C14F11.2 Protein containing six leucine rich repeats, which mediate protein-protein interactions, has a region of low similarity to a region of C. elegans SOC-2, which is a positive regulator of the let-60 ras pathway and vulval induction C14F11.3 gur-2;C14F11.3 Member of the seven-transmembrane receptor odorant receptor family, which function in olfaction, has moderate similarity to uncharacterized C. elegans GUR-3 chemoreceptor C14F11.4 C14F11.4 Protein of unknown function C14F11.5 hsp43;C14F11.5 Member of the Hsp20 or alpha crystallin family, has a region of low similarity to heat shock 27kD protein 1 (human HSPB1), which plays a role in thermotolerance and functions as a chaperone and negative regulator of apoptosis heat shock protein; hsp-43 encodes a member of the hsp20 family. C14F11.6 C14F11.6 Member of the dTDP-4-dehydrorhamnose 3,5-epimerase family, which catalyze isomerisation in lipopolysaccharide biosynthesis DTDP-4-dehydrorhamnose 3,5-epimerase (RFBC gene) C14F11.7 C14F11.7 Protein of unknown function C14F5.1 bcl-2;nip3;ceBNIP3;C14F5.1 Similar to human BNIP3; induces cell death almost as efficiently as human BNIP3 in 293T cells C14F5.2 zig-3;C14F5.2 Putative member of Immunoglobulin superfamily IG-like C2-type domain C14F5.3 C14F5.3 Member of the troponin family, which regulate calcium-induced muscle contraction troponin T; tnt-3 is orthologous to the human gene TROPONIN T (TNNT2; OMIM:191045), which when mutated leads to disease. C14F5.4 C14F5.4 Member of the mitochondrial tricarboxylate carrier (MTC) protein family C14F5.5 sem-5;C14F5.5 Cell signaling protein with SH2 and SH3 domains that is required for vulval induction and sex myoblast migration; putative ortholog of murine GRB2 or growth factor receptor-bound protein 2 C. elegans sem-5; sem-5 encodes a Src homology (SH) domain 2 and 3-containing protein, orthologous to human GRB2 (OMIM:108355), that functions in multiple signaling pathways during development; these pathways include those regulating sex myoblast migration, vulval induction, fluid balance, viability, and formation of the male tail; SEM-5 acts downstream of the LET-23 epidermal growth factor receptor to negatively regulate RAS-MAP-, as well as IP-3-, mediated signal transduction. C14H10.1 C14H10.1 Member of the ZIP zinc transporter family, which may be metal transporters Yeast YIL023C-like protein C14H10.2 C14H10.2 Putative coiled-coil protein, has similarity to myosins and human Golgi autoantigens C14H10.3 C14H10.3 Protein of unknown function, has low similarity to uncharacterized mouse Kiaa0251-hp terminase domain C14H10.4 C14H10.4 Member of the 7-transmembrane chemoreceptor family of G protein-coupled receptors (GPCR), has low similarity to C. elegans ODR-10, which is involved in odorant response C15A11.1 C15A11.1 Protein containing a collagen triple helix repeat, has moderate similarity to a region of alpha 2 subunit of type XI collagen (human COL11A2), which is associated with some forms of Stickler syndrome and Chondrodystrophy with sensorineural deafness collagen; col-35 encodes a collagen that is individually dispensable for viability and gross morphology in mass RNAi screens; the amino- and carboxyl-terminal cysteine-rich regions of COL-35 are most closely related to those of COL-8, COL-19, and COL-39. C15A11.2 C15A11.2 Protein of unknown function, has moderate similarity to uncharacterized C. elegans Y67A6A.1 C15A11.3 C15A11.3 Protein containing a CUB domain, which occurs extracellularly often in developmentally regulated proteins CUB domain C15A11.4 C15A11.4 Protein of unknown function, has high similarity to uncharacterized C. elegans C15A11.7 amine oxidase C15A11.5 col-7;C15A11.5 Collagen collagen; col-7 encodes a member of the collagen superfamily containing collagen triple helix repeats (20 copies); expressed during the L2-to-dauer molt and the L4-to-adult molt. C15A11.6 C15A11.6;col-7 Protein containing three collagen triple helix repeats, which are found in some extracellular proteins, and a nematode cuticle collagen N-terminal domain, has moderate similarity to a region of C. elegans BLI-1 collagen C15A11.7 C15A11.7 Protein of unknown function, has high similarity to uncharacterized C. elegans C15A11.4 amine oxidase C15A7.1 C15A7.1 Protein containing two neurotransmitter-gated ion-channel ligand binding domains, has a region of weak similarity to a region of alpha 7 subunit of the neuronal nicotinic acetylcholine receptor (human CHRNA7), which is highly permeable to calcium acetylcholine receptor C15A7.2 C15A7.2 Protein of unknown function, has weak similarity to C. elegans T04F8.2 C15A7.3 C15A7.3 Protein of unknown function C15B12.1 C15B12.1 Protein with moderate similarity to peroxisomal sarcosine oxidase (mouse Pso), which is a peroxisomal flavoprotein that catalyzes the oxidation of L-pipecolic acid and sarcosine and is inhibited by N-bromosuccinimide sarcosine oxidase C15B12.2 C15B12.2 Protein of unknown function C15B12.3 C15B12.3 Protein of unknown function C15B12.4 C15B12.4 Protein with weak similarity to C. elegans H02F09.3 gene product C15B12.5 gar-1;C15B12.5 G protein-linked acetylcholine receptor with three alternatively spliced forms Muscarinic acetycholine receptor; gar-1 encodes a G-protein-linked acetylcholine receptor; though gar-1 is most closely related to muscarinic acetylcholine receptors (mAChR), it is pharmacologically distinct from them in its response to certain ligands; gar-1 gene transcripts are expressed at all developmental stages; the GAR-1-GFP fusion protein is expressed in some head neurons and in the PVM neuron; electrophysiological studies indicate that gar-1 couples to the inhibitory subunit of G proteins and not to Gs or to Go/Gq. C15B12.6 C15B12.6 Protein of unknown function C15B12.7 cdf-1;C15B12.7 Member of the cation efflux family, which may be membrane divalent cation transporters, has low similarity to zinc transporter 1 (rat Slc30a1), which lowers intracellular zinc by stimulating zinc efflux and reduces vulnerability to Zn2+ induced toxicity Cobalt uptake protein (S. cerevisiae); a cation diffusion facilitator protein, affects vulva development, genetically interacts with let-60/ras signaling pathway; and is expressed in the vulval muscles, the intestinal cells, and in the vulval precursor cells. C15B12.8 C15B12.8 Putative ortholog of C. elegans C15B12.1 gene product C15C6.1 C15C6.1 Protein of unknown function C15C6.2 C15C6.2 Protein of unknown function, has low similarity to uncharacterized C. elegans R09E10.6 C15C6.3 C15C6.3 Protein of unknown function C15C6.4 C15C6.4 Protein containing a UPF0086 domain of unknown function, has low similarity to a region of processing of precursor 4 homolog (human POP4), which is a subunit of tRNA processing enzyme ribonuclease P and ribosomal RNA processing enzyme ribonuclease MRP C15C7.1 C15C7.1 Protein of unknown function, contains a putative transmembrane domain, has weak similarity to human vesicle trafficking and docking proteins syntaxin 6 and SNAP25 (synaptosomal-associated protein, 25kD) (Hs.157144, Hs.84389) C15C7.2 C15C7.2 Protein containing a large coiled-coil domain and a putative golgi-localization (GRIP) domain klp-8 encodes an atypical kinesin-like motor protein with the motor domain in the N-terminus; the motor domain of KLP-8 exhibits poor homology to the globular motor domain of the kinesin heavy chain. C15C7.3 C15C7.3 Protein of unknown function C15C7.4 C15C7.4 Protein of unknown function C15C7.5 C15C7.5 Protein of unknown function C15C7.6 C15C7.6 Protein of unknown function C15C8.1 C15C8.1 Protein with moderate similarity to C. elegans K02E2.1 gene product C15C8.2 C15C8.2 Protein containing two PAS (Per, Arnt, Sim) domains, which may participate in sensory transduction, has weak similarity to a region of mouse Hif1a, which is a basic helix-loop-helix transcription factor Human ARNT-interacting protein like; cky-1 encodes a member of the basic-helix-loop-helix-PAS (bHLH-PAS) protein family; it is likely that CKY-1 together with AHA-1, another bHLH-PAS protein, has a role in pharyngeal function; CKY-1 is expressed in most non-neuronal pharyngeal cells. C15C8.3 C15C8.3 Member of the aspartyl (acid) protease family, has moderate similarity to C. elegans ASP-6, which is an aspartyl protease involved in protein degradation cathepsin-like protease C15C8.4 C15C8.4 Protein of unknown function Human alpha-2-macroglobulin receptor-associated protein like C15C8.5 C15C8.5 Protein of unknown function, has low similarity to uncharacterized C. elegans F44D12.2 C15C8.6 C15C8.6 Protein of unknown function C15C8.7 C15C8.7 Member of the G protein alpha subunit family C15F1.1 C15F1.1 Protein with strong similarity to C. elegans C28H8.5 C15F1.2 C15F1.2 Protein of unknown function C15F1.3 tra-2;C15F1.3 Transmembrane protein that promotes female development in animals that have two X chromosomes sex-determination protein; The tra-2 gene encodes a transmembrane receptor that functions in the sex determination pathway to specify hermaphrodite development in XX animals; tra-2 encodes two proteins: TRA-2A, the major protein expressed at all developmental stages, and TRA-2B, a form specific to the hermaphrodite germ line; in hermaphrodites, direct interaction between the TRA-2A intracellular domain inhibits FEM-3 masculinizing activity, whereas in males, TRA-2A is negatively regulated by HER-1, allowing the FEM proteins to specify male development. | The tra-2 gene encodes a transmembrane receptor that functions in the sex determination pathway to specify female fates in hermaphroditic XX animals; tra-2 encodes two proteins: TRA-2A, the major protein expressed at all developmental stages, and TRA-2B, a form specific to the hermaphrodite germ line; in hermaphrodites, direct interaction between the TRA-2A intracellular domain inhibits FEM-3 masculinizing activity, whereas in males, TRA-2A is negatively regulated by HER-1, allowing the FEM proteins to specify male development. C15F1.5 C15F1.5 Protein with weak similarity to C. elegans C16A3.7 (Protein with similarity to transcription factors, possible ortholog of S. cerevisiae Fap1p) zinc finger protein C15F1.6 C15F1.6 Protein with strong similarity to D. melanogaster CG10849 (CG10849 gene product) a protein similar to synaptic glycoprotein SC2 from mammals. C15F1.8 C15F1.8 Protein of unknown function C15F1.B sod-1;C15F1.7;C15F1.B Member of the superoxide dismutase, Cu/Zn protein family with strong similarity to human SOD1; appears to control an important determinant of aging in C. elegans C15F1.E ppp-1;C15F1.4;C15F1.E Protein containing a putative NTP transferase (nucleotidyl transferase) domain, has weak similarity to S. cerevisiae Psa1p (mannose-1-phosphate guanyltransferase; GDP-mannose pyrophosphorylase) C15H11.1 C15H11.1 Protein containing a major sperm protein (MSP) domain, which are involved in sperm motility, has weak similarity to uncharacterized C. elegans ZK354.7 C15H11.2 C15H11.2 Member of the rhodopsin family of G protein-coupled receptors (GPCR), has weak similarity to arginine vasopressin receptor 1B (mouse Avpr1b), which acts through multiple second messengers and induces release of ACTH from the pituitary G-protein coupled receptor C15H11.4 C15H11.4 Protein contains a putative short chain dehydrogenase domain, has strong similarity to C. elegans E04F6.7 protein dehydrogenase; dhs-22 encodes a short-chain dehydrogenase predicted to be mitochondrial. C15H11.5 C15H11.5 Protein containing a SET domain, which are involved in protein-protein interactions C15H11.7 pas-1;C15H11.7 Putative alpha-type subunit of 20S proteasome particle proteasome component (A-type); pas-1 encodes a type 6 alpha subunit of the 26S proteasome's 20S protease core particle (CP); PAS-1 is required for embryonic development and by homology, is predicted to comprise the outer rings of the proteasome and to play a role in selective degradation of ubiquitinated proteins during development; in vitro, PAS-1 interacts with VET-1, a coiled-coil domain-containing protein expressed in the early embryo and ATN-1, an alpha-actinin, in addition to other members of the proteasome. C15H11.8 C15H11.8 Member of the S-II (TFIIS) transcription factor family, has moderate similarity to zinc ribbon domain-containing 1 (human ZNRD1), which is a zinc-binding protein that may be involved in transcription or nucleic acid metabolism DNA-directed RNA polymerase I like C15H11.9 C15H11.9 Protein of unknown function, has a region of moderate similarity to S. cerevisiae Rrs1p, which is a regulator of ribosome synthesis Human HA0609 protein like C15H11.D C15H11.6;C15H11.d Protein of unknown function, has high similarity to a region of C. elegans C15H11.3, which is a nucleocytoplasmic transporter involved in embryogenesis and morphogenesis C15H11.E C15H11.3;C15H11.e Putative paralog of C. elegans C15H11.6, has similarity to S. cerevisiae RNA-binding protein Mex67p C15H7.3 C15H7.3 Member of the protein-tyrosine phosphatase family, which are involved in control of cell growth, proliferation, differentiation and transformation, has high similarity to uncharacterized C. elegans W01B6.6 Protein tyrosine phosphatase (non-receptor class) C15H7.4 C15H7.4 Protein of unknown function, has high similarity to uncharacterized C. elegans C10C6.3 C15H9.1 C15H9.1 Putative nicotinamide nucleotide transhydrogenase NAD(P) transhydrogenase, mitochondrial; nnt-1 encodes a proton-pumping nicotinamide nucleotide transhydrogenase predicted to be mitochondrial. C15H9.10 C15H9.10 Protein of unknown function C15H9.11 C15H9.11 Protein of unknown function C15H9.2 C15H9.2 Protein containing a BTB (BR-C, ttk and babor) or POZ (Pox virus and zinc finger) domain, which are found in some DNA and actin binding proteins and may mediate protein-protein interactions C15H9.3 C15H9.3 Member of the rhodopsin family of G protein-coupled receptors (GPCR) C15H9.4 C15H9.4 Protein of unknown function that has a region of moderate similarity to H. sapiens KIAA0779 C15H9.5 C15H9.5 Protein of unknown function, has low similarity to uncharacterized human GPR108 C15H9.6 hsp-3;C15H9.6 Heat shock cognate hsp70C heat shock protein; hsp-3 encodes a heat shock response 70 (hsp70) protein orthologous to human glucose regulated protein 78 (grp78/BiP, OMIM:138120); HSP-3 likely functions as a molecular chaperone, and is expressed constitutively (expression is not heat inducible) throughout development with greatest abundance during the L1 larval stage; HSP-3 contains a long hydrophobic amino terminus and a carboxyl terminal KDEL sequence suggesting that it may be retained in the endoplasmic reticulum. C15H9.7 C15H9.7;XG726 Protein with high similarity to kynureninase (L-kynurenine hydrolase, rat Kynu), which is a pyridoxal phosphate dependent enzyme that cleaves L-kynurenine and L-3-hydroxykynurenine to anthranilic and 3-hydroxyanthranilic acids kynureninase C15H9.8 C15H9.8 Protein of unknown function, has low similarity to a region of peroxisomal biogenesis factor 3 (peroxin 3, rat Pex3), which is an integral peroxisomal membrane protein required for peroxisome biogenesis prx-3 is orthologous to the human gene PEROXISOMAL BIOGENESIS FACTOR 3 (PEX3; OMIM:603164), which when mutated leads to Zellweger syndrome of complementation group G. C15H9.9 C15H9.9 Protein of unknown function, has weak similarity to C. elegans K11H12.7 C16A11.1 gpa-11;C16A11.1 Member of the G protein alpha subunit family guanine nucleotide-binding protein; gpa-11 encodes a member of the G protein alpha subunit family of heterotrimeric GTPases; it is expressed in ADL and ASH amphid neurons. C16A11.2 C16A11.2 Protein of unknown function, has weak similarity to uncharacterized C. elegans C31E10.6 C16A11.3 C16A11.3 Protein containing a two protein kinase domains, has a region of low similarity to a region of CDC-like kinase 3 (rat Clk3), which is a protein kinase that is predominantly expressed in testis protein kinase C16A11.4 C16A11.4 Protein containing a PHD-finger, which may be involved in chromatin-mediated transcriptional regulation, has moderate similarity to uncharacterized C. elegans Y14H12B_90.A C16A11.5 C16A11.5 Protein of unknown function, has weak similarity to uncharacterized C. elegans F46F2.1 C16A11.6 C16A11.6 Protein containing an F-box domain, which serve as a link between a target protein and a ubiquitin-conjugating enzyme C16A11.7 C16A11.7 Protein of unknown function, has high similarity to uncharacterized C. elegans F32B6.4 C16A11.8 C16A11.8 Protein of unknown function, has low similarity to uncharacterized C. elegans R13F6.8 C16A3.1 C16A3.1 Protein containing two helicase conserved C-terminal domains and two SNF2 related N-terminal domains, has moderate similarity to a region of mouse Smarcal1, which is a single-stranded DNA-dependent ATPase helicase C16A3.10 C16A3.10 Protein with high similarity to ornithine aminotransferase (L ornithine:2 oxoacid delta aminotransferase, human OAT), which has a role in retinal degeneration, member of the aminotransferase class III pyridoxalphosphate-dependent enzyme family ornithine aminotransferse precursor; The C16A3.10 gene encodes a homolog of the human gene OAT (OMIM:258870), which when mutated leads to ornithinemia and gyrate atrophy. C16A3.2 C16A3.2 Protein containing a dual specificity phosphatase catalytic domain, has low similarity to human DUSP3, which is a dual specificity phosphatase that dephosphorylates phosphotyrosine and phosphoserine residues to inactivate MAPK protein-tyrosine phosphatase C16A3.3 C16A3.3 Protein containing three S1 RNA binding domains, has weak similarity to S. cerevisiae Rrp5p, which is a protein required for processing of pre-rRNA to 18S and 5.8S rRNA C16A3.4 C16A3.4 Protein containing three C2H2 type zinc finger domains, which bind nucleic acids, has low similarity to uncharacterized human MGC17552 C16A3.5 C16A3.5 Protein of unknown function, has low similarity to uncharacterized NADH dehydrogenase ubiquinone 1 beta subcomplex 9 (22 kDa) (human NDUFB9), which is a putative subunit of the NADH-ubiquinone oxidoreductase multiprotein complex that transports electrons NADH-ubiquinone oxidoreductase B22 C16A3.6 C16A3.6 Protein with moderate similarity to S. cerevisiae Mak16p, which is a nuclear protein that is required for propagation of M1 double-stranded RNA (dsRNA) virus C16A3.7 C16A3.7 Protein containing nine zinc finger domains and an R3H domain, which may bind ssDNA, has moderate similarity to nuclear transcription factor X-box binding 1 (human NFX1), which is a transcription repressor that may regulate inflammatory response duration human NFX1; D. melanogaster shuttle craft protein; C16A3.7 encodes a protein with multiple zinc-finger domains, an R3H domain, and a glutamine/asparagine-rich domain. C16A3.8 C16A3.8 Protein of unknown function, has weak similarity to a region of S. cerevisiae Rlr1p, which is involved in transcription and transcription-associated recombination and has pleiotropic regulatory properties C16A3.9 rps-13;C16A3.9 Protein with high similarity to ribosomal protein S13 (S. cerevisiae Rps13p), which is a structural ribosomal protein, member of the ribosomal S15 family, which are part of the small ribosomal subunit 40S ribosomal protein S13; rps-13 encodes a small ribosomal subunit S13 protein; by homology, RPS-13 is predicted to function in protein biosynthesis; in C. elegans, RPS-13 activity is required for embryonic and germline development. C16B8.1 lin-18;C16B8.1;Ceryk Putative receptor tyrosine kinase; may play a role in establishing cell polarity; similar to human fibroblast growth factor receptor protein kinase and D. melanogaster DRL (derailed) protein kinase protein tyrosine kinase; lin-18 encodes a predicted receptor tyrosine kinase that is a member of the Ryk/Derailed family of tyrosine kinase-related receptors (OMIM:600524, mutations in humans are associated with cleft palate); in C. elegans, LIN-18 is required for establishing the polarity of the secondary vulval cell lineage produced by the P7.p hypodermal blast cell; LIN-18 may be a receptor for Wnt-like signaling molecules, and in vulval development appears to function independently of, but in parallel with, LIN-17, a Frizzled-like Wnt receptor, also required for proper orientation of the P7.p lineage. | lin-18 encodes a predicted receptor tyrosine kinase that is a member of the Ryk/Derailed family of tyrosine kinase-related receptors (OMIM:600524, mutations in humans are associated with cleft palate); in C. elegans, LIN-18 is required for establishing the polarity of the secondary vulval cell lineage produced by the P7. C16B8.2 C16B8.2 Protein of unknown function C16B8.3 C16B8.3 Protein of unknown function C16B8.4 C16B8.4 Protein of unknown function C16C10.1 C16C10.1 Member of the mitochondrial carrier protein family of membrane transporters, has low similarity to S. cerevisiae Sfc1p, which is the mitochondrial membrane succinate-fumarate transporter carrier protein C16C10.10 C16C10.10 Member of the glyoxalase, bleomycin resistance or dioxygenase superfamily, which are involved in the glyoxal pathway Glyoxalase C16C10.11 C16C10.11 Protein of unknown function, high similarity to uncharacterized human LOC51142 C16C10.12 C16C10.12 Member of the ABC transporter family, which are involved in translocation across biological membranes, has low similarity to ATP-binding cassette subfamily G member 2 (mouse Abcg2), which is a transporter involved in multidrug resistance ATP binding transport protein (White protein) C16C10.2 C16C10.2 Protein of unknown function, has moderate similarity to uncharacterized human LOC51118 C16C10.3 C16C10.3 Piwi-related protein with similarity over the C-terminal region to human and D. melanogaster PIWI proteins and C. elegans PRG-1 and PRG-2, all of which are involved in germ-line proliferation C16C10.4 C16C10.4 Protein with high similarity to sin3 associated protein 18 kD (human SAP18), which is a component of the Sin3-histone deacetylase corepressor complex that functions as a transcription co-repressor C16C10.5 C16C10.5 Protein containing a C3HC4 type RING zinc finger, which may mediate protein-protein interactions Glutaredoxin, Zinc finger, C3HC4 type (RING finger) C16C10.6 C16C10.6 Protein with weak similarity to C. elegans unc-89, a muscle cell protein of the immunoglobulin-like protein family that is required for coordinated locomotion C16C10.7 C16C10.7 Protein containing a C3HC4 type RING zinc finger, which may mediate protein-protein interactions, has moderate similarity to uncharacterized RING finger protein 5 (mouse Rnf5) Zinc finger, C3HC4 type (RING finger); This gene encodes a homolog of mammalian RNF5, a C3HC4 (RING-finger) zinc-finger protein. C16C10.8 C16C10.8 Protein with similarity to mouse LYAR protein, a cell growth regulating nucleolar protein cell growth regulating protein C16C10.9 C16C10.9 Protein of unknown function C16C2.1 ceh-5;C16C2.1 Protein containing a homeobox (homeodomain) domain, has a region of high similarity to a region of ventral anterior homeobox containing gene 1 (mouse Vax1), which is required for the development of the visual system and is involved in axon guidance Homeobox domain; ceh-5 encodes a homeodomain protein, similar to the human VENTRAL ANTERIOR HOMEO BOX 2 gene (VAX2; OMIM:604295); CEH-5 is dispensable for viability and gross morphology. C16C2.2 eat-16;C16C2.2 Putative regulator of G protein signalling regulator of G-protein signalling; The eat-16 gene encodes an RGS protein that affects movement, pharyngeal pumping, egg laying, and synaptic transmission; it genetically interacts with the egl-30 and goa-1 signaling pathways, and is expressed in excitable cells and in the spermatheca. C16C2.3 C16C2.3 Putative phosphatidylinositol (4,5) bisphosphate 5-phosphatase inositol-1,4,5-triphosphate 5-phosphatase; The C16C2.3 gene encodes an inositol-1,4,5-triphosphate 5-phosphatase homolog that is homologous to human OCRL. C16C2.4 C16C2.4 Protein of unknown function, has low similarity to uncharacterized human SYAP1 C16C4.1 C16C4.1 Protein of unknown function, has weak similarity to C. elegans C46F9.4 C16C4.10 C16C4.10 Protein containing two meprin and TRAF homology (MATH) domains, has high similarity to uncharacterized C. elegans C16C4.5 C16C4.11 C16C4.11 Protein containing two meprin and TRAF homology (MATH) domains, has high similarity to uncharacterized C. elegans C16C4.10 C16C4.12 C16C4.12 Protein containing two meprin and TRAF homology (MATH) domains, has high similarity to uncharacterized C. elegans C16C4.5 C16C4.13 C16C4.13 Protein containing three meprin and TRAF homology (MATH) domains, has high similarity to uncharacterized C. elegans ZK250.7 C16C4.14 C16C4.14 Protein containing two meprin and TRAF homology (MATH) domains, has moderate similarity to uncharacterized C. elegans C46F9.1 C16C4.15 C16C4.15 Protein containing two meprin and TRAF homology (MATH) domains, has high similarity to uncharacterized C. elegans C16C4.4 C16C4.16 C16C4.16 Protein containing a meprin and TRAF homology (MATH) domain, has moderate similarity to uncharacterized C. elegans C16C4.3 C16C4.2 C16C4.2 Protein containing a meprin and TRAF homology (MATH) domain, has weak similarity to uncharacterized C. elegans F40B1.1 C16C4.3 C16C4.3 Protein containing two meprin and TRAF homology (MATH) domains, has high similarity to uncharacterized C. elegans C16C4.8 C16C4.4 C16C4.4 Protein containing two meprin and TRAF homology (MATH) domains, has high similarity to uncharacterized C. elegans C16C4.15 C16C4.5 C16C4.5 Protein containing two meprin and TRAF homology (MATH) domains, has high similarity to uncharacterized C. elegans C16C4.10 C16C4.6 C16C4.6 Protein containing an F-box domain, which serve as a link between a target protein and a ubiquitin-conjugating enzyme This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins; its encoded protein also contains a Pfam-B45 motif of presently unknown function. C16C4.7 C16C4.7 Protein of unknown function C16C4.8 C16C4.8 Protein containing two meprin and TRAF homology (MATH) domains, has high similarity to uncharacterized C. elegans C16C4.3 C16C4.9 C16C4.9 Protein containing three meprin and TRAF homology (MATH) domains, has high similarity to uncharacterized C. elegans C16C4.10 C16C8.10 C16C8.10 Protein with moderate similarity to C. elegans Y49F6B.H gene product C16C8.11 C16C8.11 Member of the ubiquitin family, has low similarity to uncharacterized C. elegans C16C8.4 C16C8.12 C16C8.12 Member of the ubiquitin family, has moderate similarity to uncharacterized C. elegans C16C8.14 C16C8.13 C16C8.13 Member of the ubiquitin family, has high similarity to uncharacterized C. elegans C16C8.14 C16C8.14 C16C8.14 Member of the ubiquitin family, has high similarity to uncharacterized C. elegans C16C8.13 C16C8.16 C16C8.16 Member of the ubiquitin family C16C8.17 C16C8.17 Protein of unknown function, has weak similarity to C. elegans F14H3.7 C16C8.18 C16C8.18 Protein with moderate similarity to C. elegans R13H9.1 gene product C16C8.19 C16C8.19 Protein of unknown function C16C8.2 C16C8.2 Member of the animal heme peroxidase family, has low similarity to eosinophil peroxidase (mouse Epx), which plays a role in the production of reactive oxidants that may have cytotoxic effects during the pathogen defense response and inflammation peroxidase precursor C16C8.4 C16C8.4 Member of the ubiquitin family, has low similarity to uncharacterized C. elegans C16C8.11 C16C8.5 C16C8.5 Member of the ubiquitin family C16C8.6 C16C8.6 Member of the transposase family, which are required for excising and inserting mobile genetic elements, has very strong similarity to uncharacterized C. elegans Y73B3A.19 transposase C16C8.7 C16C8.7 Protein of unknown function C16C8.8 C16C8.8 Protein of unknown function, has high similarity to uncharacterized C. elegans C16C8.9 C16C8.9 C16C8.9 Protein of unknown function, has high similarity to uncharacterized C. elegans C16C8.8 C16D2.1 C16D2.1 Protein of unknown function C16D6.1 C16D6.1 Protein of unknown function C16D6.2 C16D6.2 Member of the rhodopsin family of G protein-coupled receptors (GPCR), has low similarity to C. elegans NPR-1 7 transmembrane receptor (rhodopsin family) C16D6.3 C16D6.3 Protein of unknown function C16D9.1 C16D9.1 Protein containing two PAN domains, which may mediate protein-protein or protein-carbohydrate interactions C16D9.2 C16D9.2 Protein containing three fibronectin type III domains, which are involved in cell surface binding, and two protein kinase domains, has weak similarity to mouse Ros1, which is a proto-oncogene and protein tyrosine kinase with transformation potential tyrosine-protein kinase; rol-3 was identified in screens for recessive mutations that affect body morphology; strong loss-of-function mutations in rol-3 result in early-to-mid larval lethality, while weaker mutations result in animals that are left-handed rollers at the adult stage only; lethal rol-3 mutations are suppressed by mutations in srl-1 and srl-2; the molecular identity of rol-3 is not yet known. C16D9.3 C16D9.3 Protein containing a DUF235 domain of unknown function, has high similarity to uncharacterized C. elegans C17A2.6 C16D9.4 C16D9.4 Protein containing a DUF235 domain of unknown function, has high similarity to uncharacterized C. elegans C16D9.5 C16D9.5 C16D9.5 Protein containing a DUF235 domain of unknown function, has high similarity to uncharacterized C. elegans F22E5.1 C16D9.6 C16D9.6 Putative ortholog of C. elegans T22B11.2 gene product C16D9.7 C16D9.7 Protein containing a DUF32 domain of unknown function, has high similarity to uncharacterized C. elegans C24B9.2 7TM chemoreceptor, srt family C16D9.8 C16D9.8 Protein of unknown function C16D9.9 C16D9.9 Protein of unknown function C16E9.1 C16E9.1 Protein containing two von Willebrand factor (vWF) type A domains, has weak similarity to matrilin 1 (cartilage matrix protein, mouse Matn1), which is a putative component of the extracellular matrix that forms homodimers and binds collagen and aggrecan C16E9.2 C16E9.2 Protein of unknown function C16E9.4 opu-1;pcr55;C16E9.4 Protein with high similarity to C. elegans UNC-7, which is required in motor neurons for coordinated locomotion, member of the integral membrane innexin family, which are involved in the formation of gap junctions inx-1 encodes a predicted member of the innexin family; expressed in 4-6 anterior neurons. C16E9.5 C16E9.5 Protein of unknown function C16E9.6 C16E9.6 Protein of unknown function C16H3.1 C16H3.1 Protein with low similarity to Kv4 channel-interacting protein 2 (mouse Kcnip2), which interacts with alpha subunits of Kv4 potassium channels to regulate the Kv4.2-mediated transient outward potassium current and is associated with cardiac arrythmias calcium binding proteins C16H3.2 lec-9;C16H3.2 Member of the galectin family, which are lectins that bind beta galactosides, has low similarity to a region of galactoside-binding soluble 9 (galectin 9, human LGALS9), which is a lectin that is involved in cell adhesion and chemoattraction sugar-binding protein; lec-9 encodes a predicted lectin that affects embryonic viability. C16H3.3 C16H3.3 Protein with strong similarity to C. elegans C16H3.4 gene product C17A2.1 C17A2.1 Protein containing a nuclear hormone receptor C4-type zinc finger domain, which bind DNA and may be involved in transcription regulation, has strong similarity to uncharacterized C. elegans C49D10.9 zinc finger protein C17A2.2 C17A2.2 Protein containing a DUF138 domain of unknown function, has high similarity to uncharacterized C. elegans T05B11.4 C17A2.3 C17A2.3 Protein of unknown function, has high similarity to uncharacterized C. elegans F56H6.1 C17A2.4 C17A2.4 Member of the glycosyl transferase family 11, which hydrolyze the glycosidic bond between two or more carbohydrates, has high similarity to uncharacterized C. elegans Y5H2B.1 C17A2.5 C17A2.5 Protein containing three DUF33 domains of unknown function, has high similarity to uncharacterized C. elegans F14B6.5 C17A2.6 C17A2.6 Protein containing a DUF235 domain of unknown function, has high similarity to uncharacterized C. elegans C16D9.3 C17A2.7 C17A2.7 Member of the domain of unknown function DUF13 family, has high similarity to uncharacterized C. elegans R09H10.2 C17A2.8 nhr-72;C17A2.8 Member of the zinc finger protein family, may be involved in epidermal fate specification zinc finger protein C17B7.1 C17B7.1 Member of the 7-transmembrane chemoreceptor family of G protein-coupled receptors (GPCR), has weak similarity to C. elegans STR-2, which is expressed in either the left or right AWC odorant neurons as a result of a stochastic process 7TM chemoreceptor, str family C17B7.10 C17B7.10 Member of the M13 peptidase family of zinc metalloproteases, has high similarity to uncharacterized C. elegans T28A11.20 C17B7.10 encodes a neprilysin; neprilysins are thermolysin-like zinc metallopeptidases, found on the outer surface of animal cells, that negatively regulate small signalling peptides (e.g., enkephalin, tachykinin, insulin, and natriuretic peptides) by cleaving them; C17B7.10 has no clear orthologs in other organisms. C17B7.11 C17B7.11 Protein containing an F-box domain, which serve as a link between a target protein and a ubiquitin-conjugating enzyme, and a DUF38 domain of unknown function, has low similarity to C. elegans FOG-2 This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins; this gene's encoded protein also contains an FTH/DUF38 motif, which may also mediate protein-protein interaction. C17B7.12 C17B7.12 Protein of unknown function, putative paralog of F35F10.5 C17B7.2 C17B7.2 Protein containing two DUF19 domains of unknown function, which contain twelve conserved cysteines, has high similarity to uncharacterized C. elegans T28A11.2 C17B7.3 C17B7.3 Protein containing a DUF19 domain of unknown function, which contain twelve conserved cysteines, has strong similarity to uncharacterized C. elegans T28A11.3 C17B7.4 C17B7.4 Protein containing a DUF19 domain of unknown function, which contain twelve conserved cysteines, has strong similarity to uncharacterized C. elegans T28A11.5 C17B7.5 C17B7.5 Protein of unknown function, has high similarity to uncharacterized C. elegans F35F10.10 C17B7.6 C17B7.6 Protein of unknown function, has high similarity to uncharacterized C. elegans T01C1.1 C17B7.7 C17B7.7 Putative ortholog of C. elegans F23A7.5 gene product C17B7.8 C17B7.8 Member of the M13 peptidase family of zinc metalloproteases, has strong similarity to uncharacterized C. elegans T28A11.17 C17B7.8 encodes a neprilysin; neprilysins are thermolysin-like zinc metallopeptidases, found on the outer surface of animal cells, that negatively regulate small signalling peptides (e.g., enkephalin, tachykinin, insulin, and natriuretic peptides) by cleaving them; C17B7.8 has no clear orthologs in other organisms. C17B7.9 C17B7.9 Protein containing a DUF19 domain of unknown function, which contain twelve conserved cysteines, has strong similarity to uncharacterized C. elegans T28A11.18 C17C3.1 C17C3.1 Member of the Acyl-CoA thioesterase family, which hydrolyze a range of acyl-CoA thioesters, has moderate similarity to peroxisomal acyl-CoA thioesterase 1 (human PTE1), which cleaves thioester bonds on medium chain acyl CoAs and binds HIV Nef protein C17C3.10 C17C3.10 Protein of unknown function, has strong similarity to uncharacterized C. elegans C17C3.7 C17C3.11 C17C3.11 Protein of unknown function, has high similarity to uncharacterized C. elegans K11C4.1 C17C3.12 C17C3.12 Protein with high similarity to human ACADSB, which is a short branched chain acyl-CoA dehydrogenase, contains two acyl-CoA dehydrogenase N-terminal domains, two acyl-CoA dehydrogenase middle domains and six acyl-CoA dehydrogenase C-terminal domains acyl-CoA dehydrogenase C17C3.13 C17C3.13 Protein of unknown function, has very strong similarity to uncharacterized C. elegans C17C3.2 C17C3.15 C17C3.15 Protein with moderate similarity to C. elegans H12I13.1 gene product C17C3.2 C17C3.2 Protein of unknown function, has very strong similarity to uncharacterized C. elegans C17C3.13 C17C3.3 C17C3.3 Member of the Acyl-CoA thioesterase family, which hydrolyze a range of acyl-CoA thioesters, has low similarity to a region of peroxisomal acyl-CoA thioesterase 1 (human PTE1), which cleaves medium chain acyl CoAs thioester bonds and binds HIV Nef protein C17C3.4 ins-11;Ceinsulin-3;C17C3.4 Insulin-like protein of the type-gamma subfamily ins-11 encodes an insulin-like peptide of the insulin superfamily of proteins (OMIM:176730, 147440); INS-11 is one of 38 insulin-like peptides in C. elegans and is expressed in the labial sensory neurons, the nerve ring, and other neurons; although the precise role of INS-11 in C. elegans development is not yet clear, loss of INS-11 function via RNA-mediated interference can result in animals that are smaller than wild type (Sma). C17C3.5 C17C3.5 Protein containing a DUF38 domain of unknown function C17C3.6 C17C3.6 Protein of unknown function, has similarity to members of an unnamed protein family including C. elegans M162.8 This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins. C17C3.7 C17C3.7 Protein of unknown function, has strong similarity to uncharacterized C. elegans C17C3.10 C17C3.8 C17C3.8 Protein containing one helix-loop-helix DNA-binding domain, which mediate protein dimerization, has low similarity to uncharacterized C. elegans C17C3.7 C17C3.9 C17C3.9 Protein of unknown function C17D12.1 C17D12.1 Protein containing two DHHC-type zinc finger (NEW1) domains, has a region of moderate similarity to a region of huntingtin interacting protein H (human HYPH), which is associated with Huntington disease C17D12.2 C17D12.2 Protein containing two RNA recognition motifs (RRM, RBD, or RNP), has moderate similarity to bruno-like 5 (human BRUNOL5), which is a pre-mRNA splicing factor involved in cell-specific alternative splicing RNA recognition motif. (aka RRM, RBD, or RNP domain) (2 domains); unc-75 encodes an RNA-binding protein with two N-terminal RNA recognition motifs (RRMs), a glutamine/asparagine-rich linker domain, and a third C-terminal RRM; UNC-75 is orthologous to mammalian CELF/BrunoL proteins that control pre-mRNA splicing; unc-75 is expressed in all neurons and in neurosecretory gland cells, and is required for normal modulation of GABA- and acetylcholine-mediated neurotransmission; UNC-75 protein is found with other RRM proteins in dynamic nuclear speckles, consistent with a role in alternative mRNA splicing; unc-75 mutations can be rescued in vivo by a human unc-75 transgene, but not by exc-7 or W02D3.11, indicating that UNC-75 acts on evolutionarily conserved but highly specific pre-mRNA substrates; both UNC-75 and EXC-7 are required in parallel for normal cholinergic neurotransmission. C17D12.3 C17D12.3 Protein of unknown function, has very strong similarity to uncharacterized C. elegans Y47H9A.1 C17D12.4 C17D12.4 Protein of unknown function C17D12.5 C17D12.5 Protein of unknown function C17D12.6 spe-9;C17D12.6 Transmembrane protein found in sperm and required for spermatogenesis EGF-like domain (2 domains); spe-9 encodes a predicted plasma membrane protein with a short intracellular domain and external EGF-like repeats most closely resembling those of the Delta, Serrate, APX-1, and LAG-2 signaling ligands; SPE-9 is required autonomously in sperm for fertilization, and by homology, likely mediates an adhesive or signaling event necessary for proper oocyte fertilization; spe-9 mRNA is detected solely in animals that are engaged in spermatogenesis; the receptor for SPE-9 is not yet known. C17D12.7 C17D12.7 Protein of unknown function C17E4.1 C17E4.1 Putative ortholog of C. elegans T09A12.1 gene product C17E4.10 C17E4.10 Protein of unknown function C17E4.2 C17E4.2 Putative coiled-coil protein, has similarity to S. cerevisiae Nuf1p, a component of the nucleoskeleton myosin heavy chain like C17E4.3 C17E4.3 Protein with weak similarity to C. elegans D2089.2 gene product C17E4.4 C17E4.4 Protein of unknown function C17E4.5 C17E4.5 Protein containing an RNA recognition motif (RRM, RBD, or RNP), has high similarity to a region of poly(A)-binding protein nuclear 1 (human PABPN1), which stimulates long poly(A) tail synthesis and is associated with oculopharyngeal muscular dystrophy RNA binding protein (RNP like); pab-3 is orthologous to human PABPN1 (OMIM:602279, mutated in oculopharyngeal muscular dystrophy). C17E4.6 C17E4.6 Protein of unknown function, has a region of low similarity to transcription factor-like 1 (mouse Tcfl1), which is a putative transcription factor YL-1 protein like C17E4.9 C17E4.9 Member of the Na+,K+ ATPase beta subunit family, which regulate the number of sodium pumps transported to the plasma membrane, has low similarity to beta 1 subunit of Na+/K+-ATPase (rat Atp1b1), which is involved in ion concentration homeostasis sodium/potassium transporting ATPase beta chain C17E7.1 C17E7.1 Protein containing a nuclear hormone receptor C4-type zinc finger domain, which bind DNA and may be involved in transcription regulation, has high similarity to a region of C. elegans NHR-58 zinc-finger protein C17E7.10 C17E7.10 Protein containing a DUF41 domain of unknown function, has moderate similarity to uncharacterized C. elegans F11A5.7 C17E7.11 C17E7.11 Member of the 7-transmembrane chemoreceptor family of G protein-coupled receptors (GPCR), has weak similarity to C. elegans ODR-10, which is a G protein-coupled receptor involved in odorant response 7TM chemoreceptor, str family C17E7.12 C17E7.12 Protein of unknown function C17E7.13 C17E7.13 Protein of unknown function C17E7.2 C17E7.2 Member of the 7-transmembrane chemoreceptor family of G protein-coupled receptors (GPCR), has high similarity to uncharacterized C. elegans R03H4.9 7TM chemoreceptor, srh family C17E7.3 C17E7.3 Member of the C. elegans Sre G protein-coupled chemoreceptor family, which are putative chemosensory receptors 7TM chemoreceptor, sre family C17E7.4 C17E7.4 Has strong similarity to C. elegans F08G2.7 gene product C17E7.5 C17E7.5 Protein containing nuclear hormone receptor ligand-binding and C4-type zinc finger domains, which bind DNA and may be involved in regulation of transcription, has moderate similarity to C. elegans NHR-51 nuclear hormone receptor C17E7.6 C17E7.6 Protein containing a nuclear hormone receptor ligand-binding domain and a nuclear hormone receptor C4-type zinc finger domain, which bind DNA and may be involved in regulation of transcription, has low similarity to C. elegans NHR-51 nuclear hormone receptor C17E7.7 C17E7.7 Protein containing a nuclear hormone receptor ligand-binding domain and a nuclear hormone receptor C4-type zinc finger domain, which bind DNA and may be involved in regulation of transcription, has low similarity to C. elegans NHR-51 nuclear hormone receptor C17E7.8 C17E7.8 Protein containing a nuclear hormone receptor ligand-binding domain and a nuclear hormone receptor C4-type zinc finger domain, which bind DNA and may be involved in regulation of transcription, has weak similarity to C. elegans NHR-51 nuclear hormone receptor C17F3.1 C17F3.1 Protein of unknown function C17F3.3 C17F3.3 Protein of unknown function, has high similarity to uncharacterized C. elegans ZK354.3 C17F4.1 C17F4.1 Protein with strong similarity to C. elegans T26E3.1 gene product C17F4.2 C17F4.2 Protein of unknown function, has weak similarity to C. elegans R11G1.2 C17F4.3 C17F4.3 Protein of unknown function, has strong similarity to uncharacterized C. elegans T23F6.2 C17F4.4 C17F4.4 Member of the 7-transmembrane chemoreceptor family of G protein-coupled receptors (GPCR), has high similarity to uncharacterized C. elegans Y94A7B.4 7TM chemoreceptor, srh family C17F4.5 C17F4.5 Protein containing an F-box domain, which serve as a link between a target protein and a ubiquitin-conjugating enzyme, has low similarity to uncharacterized C. elegans M02B7.1 This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins. C17F4.6 gcy-19;C17F4.6 Protein containing a receptor family ligand binding domain, a protein kinase domain, and an adenylate and guanylate cyclase catalytic domain, has low similarity to natriuretic peptide receptor B (rat Npr2) guanylate cyclase; gcy-19 encodes a predicted transmembrane guanylyl cyclase; as loss of gcy-19 activity via RNA-mediated interference does not result in any abnormalities, the precise role of GCY-19 in C. elegans development and/or behavior is not yet known; by sequence similarity, however, GCY-19 can be predicted to function in chemosensory signal transduction. C17F4.7 C17F4.7 Putative ortholog of C. elegans Y51F10.7 gene product C17F4.8 C17F4.8 Protein with strong similarity to C. elegans C40A11.3 gene product C17G1.1 C17G1.1 Protein of unknown function, has low similarity to uncharacterized C. elegans C17G1.2 C17G1.2 C17G1.2 Protein of unknown function, has low similarity to uncharacterized C. elegans C17G1.1 C17G1.3 C17G1.3 Protein containing a UDP-glucoronosyl and UDP-glucosyl transferase domain, has low similarity to UDP glycosyltransferase 1 family polypeptide A6 (mouse Ugt1a6), which catalyzes the glucoronidation of small planar phenolic molecules UDP-glucosyltransferase C17G1.4 C17G1.4 Protein with moderate similarity to H. sapiens MUC1 gene product, a transmembrane mucin C17G1.5 C17G1.5 Protein of unknown function, predicted to contain a glycosylphosphatidylinositol (GPI) lipid anchor C17G1.6 C17G1.6 Member of the astacin (M12A) family of metalloproteases, contains a CUB domain and a type 1 thrombospondin domain, has a region of low similarity to a region of C. elegans HCH-1, which is putative zinc-dependent metalloprotease involved in cell migration zinc metalloprotease; nas-37 encodes an extracellular matrix metalloprotease of the M12A (astacin) family that, in addition to its catalytic domain, contains an N-terminal secretion signal and EGF-like, CUB, and thrombospondin-1 domains in the C-terminal regulatory, or predicted protein-protein interaction, region; NAS-37 activity is required for efficient or full completion of the four larval molts in which older cuticle is shed and replaced by the newer, stage-specific cuticle; NAS-37 is able to induce the formation of an anterior contractile ring in cuticle from a parasitic nematode, suggesting that anterior cuticle digestion may be a conserved process in nematode ecdysis; in addition, NAS-37 may also play a minor role in normal cuticular collagen synthesis and/or processing; a NAS-37 translational reporter is expressed in the anterior hypodermis Hyp5, the excretory duct cell, and in pharyngeal, rectal, amphid, and vulval tissues; expression in Hyp5 can be see up to four hours prior to ecdysis; nas-37 promoter fusions additionally reveal expression in all hypodermal cells, although the functional significance of this more widespread expression is not yet known. C17G1.7 C17G1.7 Member of the cystathionine beta-synthase protein family cysteine synthase C17G10.1 C17G10.1 Member of the 2-oxoglutarate (2OG) and Fe(II)-dependent oxygenase family C17G10.2 C17G10.2 Protein containing two TPR (tetratrico peptide repeat) domains, which may mediate protein-protein interactions, has low similarity to S. cerevisiae Cns1p, which is a component of the Hsp90 chaperone complex TPR domain C17G10.4 C17G10.4 Member of the protein-tyrosine phosphatase family, which are involved in control of cell growth, proliferation, differentiation and transformation, has a region of moderate similarity to human CDC14A, which is a dual specificity protein phosphatase cdc-14 encodes a dual-specificity phosphatase, homologous to Cdc14p in S. cerevisiae; CDC-14 localizes to the central spindle in anaphase and to the midbody in telophase, and is required for cytokinesis and embryonic viability. C17G10.5 C17G10.5 Member of an uncharacterized protein family with weak similarity to Entemeba histolytica N-acetylmuraminidase C17G10.6 C17G10.6 Protein with weak similarity to C. elegans Y113G7B.12 gene product C17G10.7 C17G10.7 Protein of unknown function C17G10.9 C17G10.9 Protein with strong similarity to C. elegans F59E12.7 gene product C17H1.1 C17H1.1 Protein with strong similarity to C. elegans C17H1.7 gene product C17H1.2 C17H1.2 Protein of unknown function C17H1.3 C17H1.3 Protein of unknown function, has low similarity to uncharacterized C. elegans C17H1.5 C17H1.4 C17H1.4 Protein of unknown function, has low similarity to uncharacterized C. elegans F22G12.1 C17H1.5 C17H1.5 Protein of unknown function, has low similarity to uncharacterized C. elegans C17H1.3 C17H1.6 C17H1.6 Protein of unknown function, has high similarity to uncharacterized C. elegans C17H1.7 C17H1.7 C17H1.7 Protein of unknown function, has high similarity to uncharacterized C. elegans C17H1.6 C17H1.8 C17H1.8 Protein with strong similarity to C. elegans C17H1.4 gene product C17H11.1 C17H11.1 Protein of unknown function, has low similarity to uncharacterized C. elegans B0563.6 C17H11.2 C17H11.2 Protein of unknown function C17H11.3 C17H11.3 Member of the reverse transcriptase protein family, which are RNA-dependent DNA polymerases, has high similarity to uncharacterized C. elegans R05F9.4 reverse transcriptase C17H11.4 C17H11.4 Protein of unknown function, has high similarity to a region of ariadne ubiquitin-conjugating enzyme E2-binding protein homolog 1 (human ARIH1), which binds ubiquitin-conjugating enzyme E2-18 (human UBE2L3) and may play a role in protein ubiquitylation C17H11.5 C17H11.5 Protein of unknown function C17H11.6 C17H11.6 Protein with composite TRIAD zinc finger domain, has similarity to human Hs.78894 gene product, protein KIAA0161 isolated from human cell line KG-1 cDNA library, and D. melanogaster ARI2 C17H12.1 C17H12.1 Protein containing five WD domains (WD-40 repeats), which may mediate protein-protein interactions, has moderate similarity to intermediate chain 1 of cytoplasmic dynein (human DNCI1), which likely mediates cargo binding C17H12.10 C17H12.10 Protein of unknown function C17H12.11 C17H12.11 Protein with moderate similarity to C. elegans Y106G6D.4 gene product C17H12.12 C17H12.12 Protein containing a BTB (BR-C, ttk and babor) or POZ (Pox virus and zinc finger) domain, which are found in some DNA and actin binding proteins and may mediate protein-protein interactions C17H12.13 C17H12.13 Protein of unknown function C17H12.14 C17H12.14 Member of the ATP synthase E (31 kDa) subunit family, has low similarity to vacuolar H(+)-ATPase (V-ATPase) hydrophilic subunit E (S. cerevisiae Vma4p), which is the 27 kDa subunit of V1 sector ATPase C17H12.2 C17H12.2 Protein of unknown function C17H12.3 C17H12.3 Member of the protein-tyrosine phosphatase family, which are involved in control of cell growth, proliferation, differentiation and transformation, has moderate similarity to C. elegans F10G8.1, which is involved in embryogenesis or morphogenesis protein-tyrosine phosphatase C17H12.4 C17H12.4 Member of the carboxylesterase type B family, has low similarity to esterase 22 (egasyn, mouse Es22), which has a role in retaining beta-glucuronidase in the endoplasmic reticulum carboxylesterase C17H12.5 C17H12.5 Member of the protein-tyrosine phosphatase family, which are involved in control of cell growth, proliferation, differentiation and transformation, has low similarity to uncharacterized C. elegans Y57G11C.6 protein-tyrosine phosphatase C17H12.6 C17H12.6 Protein containing a DUF141 domain of unknown function, has high similarity to uncharacterized C. elegans C17H12.8 C17H12.8 C17H12.8 Protein of unknown function, has high similarity to uncharacterized C. elegans F08G5.6 C17H12.9 C17H12.9 Protein containing a homeobox (homeodomain) domain and a CUT domain, has moderate similarity to one cut domain family member 1 (hepatocyte nuclear factor-6) (mouse Onecut1), which is a transcriptional activator that regulates liver-specific genes homeobox protein; C17H12.9 encodes a ONECUT class CUT homeobox protein with a single N-terminal cut domain; the cut domain may be a compact DNA-binding domain composed of alpha helices; C17H12.9 is strongly affiliated with, and may be orthologous to, Drosophila ONECUT and mammalian HNF6 proteins; C17H12.9 has no obvious function in mass RNAi assays. C18A11.1 C18A11.1 Protein of unknown function, has weak similarity to C. elegans T24C4.3 C18A11.2 C18A11.2 Protein of unknown function C18A11.3 C18A11.3 Protein of unknown function C18A11.4 C18A11.4 Protein contains a putative SH2 domain C18A11.5 xol-1;C18A11.5 Protein that acts as a male/hermaphrodite sex determination switch C18A11.6 C18A11.6 Protein with moderate similarity to C. elegans F11A5.6 gene product C18A11.7 dim-1;C18A11.7 Putative member of immunoglobulin superfamily of proteins C18A3.1 C18A3.1 Protein of unknown function C18A3.2 C18A3.2 Member of the ZIP zinc transporter family, which may be metal transporters, has low similarity to uncharacterized C. elegans F30B5.7 C18A3.3 C18A3.3 Protein with moderate similarity to EBNA1-binding protein 2 (human EBNA1BP2), which is a nuclear protein that positively controls cell proliferation and is implicated in maintenance and segregation of latent Epstein Barr virus DNA episomes in human cells C18A3.4 C18A3.4 Protein of unknown function, has low similarity to uncharacterized C. elegans W01D2.5 C18A3.5 C18A3.5 Protein containing five RNA recognition motifs (RRM, RBD, or RNP), has moderate similarity to cytotoxic granule-associated RNA-binding protein 1 (human TIA1), which binds mRNA, functions in mRNA splicing, and may be associated with HIV progression RNA binding protein C18A3.6 rab-3;C18A3.6 GTP-binding protein of the rab family (ras superfamily), component of a neuronal transmission pathway that affects pharyngeal pumping, body thrashing, and male mating synaptic vesicle-associated GTP-binding protein; rab-3 encodes a rab3 homolog, a member of the Ras GTPase superfamily, and affects sensitivity to aldicarb and the distribution of synaptic vesicle populations and thereby affects synaptic transmission, track amplitude and speed of movement, chemotaxis to isoamyl alcohol, affects pharyngeal pump durations, and may only slightly affect male mating behavior; requires aex-3 for localization to synapse-rich regions in axons and it is expressed in most or all neurons. C18A3.7 C18A3.7 Protein of unknown function, has weak similarity to C. elegans ZC581.6 C18A3.8 C18A3.8 Protein containing one helix-loop-helix DNA-binding domain, which mediate protein dimerization helix-loop-helix transcription factor; hlh-14 encodes a basic helix-loop-helix (bHLH) transcription factor that is one of five C. elegans Achaete-Scute family homologs; HLH-14 activity is required generally for normal egg-laying, movement, body morphology, and larval development; more specifically, HLH-14 is required for proper neuronal development, particularly for regulation of the asymmetric cell division that gives rise to the PVQ/HSN/PHB neuroblasts and for normal differentiation of these neuroblast descendants, including their cell division patterns, migrations, and neurotransmitter expression; in specifying neuronal cell fates, genetic evidence suggests that hlh-14 acts together with hlh-2, which encodes the C. elegans E/Daughterless ortholog; HLH-14 is expresed exclusively in the embryo and detected in the left and right PVQ/HSN/PHB neuroblasts and their descendants, as well as in other cells identified, tentatively, as anterior neuroblasts and posterior neuroblasts such as Caapa. C18A3.9 C18A3.9 Protein of unknown function C18B10.1 C18B10.1 Protein containing a DUF40 domain of unknown function, which contain four conserved cysteines, has high similarity to uncharacterized C. elegans C18B10.2 C18B10.2 C18B10.2 Protein containing a DUF40 domain of unknown function, which contain four conserved cysteines, has high similarity to uncharacterized C. elegans C18B10.1 C18B10.3 C18B10.3 Protein containing a DUF40 domain of unknown function, which contain four conserved cysteines, has high similarity to uncharacterized C. elegans C04E12.1 C18B10.4 C18B10.4 Protein containing two DUF40 domains of unknown function, which contain four conserved cysteines, has low similarity to uncharacterized C. elegans C02A12.5 C18B10.5 C18B10.5 Protein containing a DUF40 domain of unknown function, which contain four conserved cysteines, has high similarity to uncharacterized C. elegans C04E12.1 C18B10.6 C18B10.6 Protein containing a DUF 227 domain of unknown function, high similarity to uncharacterized C. elegans Y45G12C.4 C18B10.7 C18B10.7 Member of the 7-transmembrane chemoreceptor family of G protein-coupled receptors (GPCR), has low similarity to C. elegans ODR-10, which is a G protein-coupled receptor involved in odorant response 7TM chemoreceptor, str family C18B10.8 C18B10.8 Member of the 7-transmembrane chemoreceptor family of G protein-coupled receptors (GPCR), has moderate similarity to uncharacterized C. elegans W02H5.6 7TM chemoreceptor, srh family C18B12.1 C18B12.1 Protein of unknown function C18B12.2 C18B12.2 Mmember of the secretin family of G protein-coupled receptors, contains a hormone receptor domain, has low similarity to corticotropin releasing hormone receptor 1 (mouse Crhr), which stimulates adenylyl cyclase 7 transmembrane receptor (Secretin family) C18B12.3 C18B12.3 Protein containing a homeobox (homeodomain) domain, has a region of low similarity to a region of C. elegans VAB-3, which is a homeodomain transcription factor required for morphogenesis of the head and gonads Homeobox domain; C18B12.3 encodes a paired-like homeodomain protein of the Q50 class, which has no obvious function in mass RNAi assays. C18B12.4 C18B12.4 Protein containing a C3HC4 type (RING) zinc finger, which may mediate protein-protein interactions, has a region of moderate similarity to a region of sperizin (mouse Ssrzf1), which may function in spermatogenesis Zinc finger, C3HC4 type (RING finger) C18B12.5 C18B12.5 Protein containing a DUF38 domain of unknown function, has high similarity to uncharacterized C. elegans H03G16.4 C18B12.6 C18B12.6 Protein of unknown function, has weak similarity to C. elegans K09E9.2 C18B2.1 C18B2.1 Protein of unknown function, has moderate similarity to uncharacterized C. elegans C18B2.2 C18B2.2 C18B2.2 Protein of unknown function, has moderate similarity to uncharacterized C. elegans C18B2.1 C18B2.3 C18B2.3 Protein of unknown function C18B2.4 C18B2.4 Protein containing a GRAM domain, which are found in glucosyltransferases, myotubularins and other putative membrane-associated proteins, has low similarity to WW domain binding protein 2 (human WBP2), which is involved in protein binding C18B2.5 C18B2.5 Protein of unknown function, has weak similarity to C. elegans F43B10.2 C18B2.6 C18B2.6 Member of the amiloride-sensitive sodium channel family, which are involved in sodium reabsorption, has weak similarity to neuronal amiloride-sensitive cation channel 1 (degenerin, rat Accn1), which is a non-voltage-dependent H+-gated sodium channel C18C4.1 C18C4.1 Protein of unknown function C18C4.10 klc-2;C18C4.10 Protein with high similarity to kinesin light chain 1 (mouse Klc1), which functions in anterograde axon cargo transport, contains nine TPR (tetratrico peptide repeat) domains, which may mediate protein-protein interactions kinesin light chain; klc-2 encodes a kinesin light chain and was identified as a protein that interacts with UNC-16 by the yeast two-hybrid system, this association suggests that KLC-2 may be involved in the regulation of synaptic vesicle localization by the UNC-16-JNK signaling complex. C18C4.2 C18C4.2 Putative ortholog of C. elegans Y75B8A.26 gene product trans-membrane protein C18C4.3 C18C4.3 Protein containing two UDP-glucoronosyl and UDP-glucosyl transferase domains, has low similarity to UDP glycosyltransferase 2 polypeptide B11 (human UGT2B11), which is a UDP-glucuronosyltransferase for which no substrate has been found UDP-glucuronosyltransferase C18C4.5 C18C4.5 Putative coiled-coil protein, has similarity to human CENPE, centromere protein E C18C4.6 C18C4.6 Protein of unknown function C18C4.7 C18C4.7 Protein of unknown function C18C4.9 C18C4.9 Protein with strong similarity to C. elegans C18C4.8 gene product C18D1.1 die-1;C18D1.1 Zinc finger protein required for epithelial cell rearrangement Zinc finger, C2H2 type (3 domains); die-1 encodes a C2H2 zinc finger protein containing four fingers, homologous to CG18265-PA in Drosophila; DIE-1 is autonomously required in the posterior dorsal hypodermis for intercalation, for morphogenesis in other embryonic tissues, and for normal postembryonic growth and vulval development. C18D1.2 C18D1.2 Protein with weak similarity to human sodium-dependent inorganic phosphate cotransporter NPT4, member of the major facilitator superfamily sodium/phosphate transporter C18D1.3 flp-4;C18D1.3 Putative FMRF-amide neurotransmitters FMRFamide-like peptide C18D11.1 C18D11.1 Protein of unknown function C18D11.2 C18D11.2 Protein containing an acyl CoA binding domain, has a region of moderate similarity to a region of peroxisomal D3,D2-enoyl-CoA isomerase (human PECI), which catalyzes isomerization of 3-cis-octenoyl-CoA to 2-trans-octenoyl-CoAm in fatty acid beta oxidation Acyl CoA binding protein; maa-1 encodes a predicted membrane-associated Acyl-CoA binding protein; loss of maa-1 activity via RNAi results in no obvious defects. C18D11.3 C18D11.3 Protein of unknown function C18D11.4 C18D11.4;Cetra2-beta;rsp-8 Protein with strong similarity to human SFRS10 protein and SR-like splicing factor and Drosophila TRA2, (putative RNA binding protein) RNA recognition motif. (aka RRM, RBD, or RNP domain) C18D11.5 C18D11.5 Protein of unknown function, has low similarity to a region of carbon catabolite repressor negative regulator of transcription complex subunit 2 (human CNOT2), which is a component of the CCR4-NOT global transcriptional regulator complex C18D4.1 C18D4.1 Protein with strong similarity to C. elegans K10G4.5 gene product C18D4.2 C18D4.2 Protein containing a DUF38 domain of unknown function C18D4.3 C18D4.3 Protein with strong similarity to C. elegans F28B1.6 gene product C18D4.4 C18D4.4 Protein with strong similarity to C. elegans Y61B8B.2 gene product C18D4.6 C18D4.6 Protein of unknown function, has strong similarity to uncharacterized C. elegans F31E9.6 C18D4.7 C18D4.7 Protein containing a DUF216 domain of unknown function, has high similarity to uncharacterized C. elegans F31E9.5 C18D4.8 C18D4.8 Member of an uncharacterized protein family This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins. C18D4.9 C18D4.9 Protein containing a DUF216 domain of unknown function, has low similarity to uncharacterized C. elegans Y68A4A.6 C18E3.1 C18E3.1 Protein of unknown function C18E3.2 C18E3.2 Putative ortholog of H. sapiens SMARCD3 protein, matrix associated SWI/SNF related and actin dependent regulator of chromatin The C18E3.2 gene encodes a homolog of Swp73/BAF60, a component of the SWI/SNF complex that is conserved from yeast to mammals and that is involved in chromatin remodeling; C18E3.2 is probably required during mitosis of the T cells for asymmetric cell division. C18E3.3 C18E3.3 Protein of unknown function C18E3.4 C18E3.4 Protein of unknown function C18E3.5 C18E3.5 Protein with high similarity to U5 snRNP-specific 40 kD protein (human HPRP8BP), which is a component of the U5 small nuclear ribonucleoprotein particle that binds to the 220 kDa component human PRP8, contains seven WD domains (WD-40 repeats) beta transducin C18E3.6 C18E3.6 Member of the CAP (adenylate-cyclase associated) protein family, has moderate similarity to adenylyl cyclase associated protein 2 (human CAP2), which regulates adenylyl cyclase function and may function in cell polarity regulation adenylyl cyclase-associated protein C18E3.7 C18E3.7 Piwi-related protein with similarity over the C-terminal region to human and D. melanogaster PIWI proteins and C. elegans PRG-1/PRG-2, all of which are involved in germ-line proliferation C18E3.8 hop-1;C18E3.8 Related to the H. sapiens PS1 and PS2 presenilins; required for the appropriate neurite connectivity of a small subset of interneurons, including AIY seven trans-membrane protein C18E3.9 C18E3.9 Protein of unknown function C18E9.1 C18E9.1 Protein containing four EF hand domains, which are found in signaling, buffering or transport proteins, has a region of high similarity to calmodulin 1 (human CALM1), which is involved in regulating the calcium-dependent activity of proteins and enzymes calmodulin; cal-2 encodes a calmodulin homolog required for embryonic development or viability; CAL-2 is closely similar to its paralogs CAL-1, CAL-3, CAL-4 and CMD-1. C18E9.10 C18E9.10 Protein of unknown function C18E9.11 ooc-5;C18E9.11 Putative ATPase that may function as a chaperone in the assembly or disassembly of proteins or protein complexes C18E9.2 C18E9.2 Protein of unknown function, has a region of low similarity to S. cerevisiae Sec62p, which is a component of ER protein-translocation subcomplex that includes Sec62p, Sec63p, Sec66p, and Sec72p Drosophila translocation protein 1 like C18E9.3 C18E9.3 Protein of unknown function, has weak similarity to C. elegans F40F11.2 The protein product of this gene is predicted to contain a glutamine/asparagine (Q/N)-rich ('prion') domain, by the algorithm of Michelitsch and Weissman (as of the WS77 release of WormBase, i.e., in wormpep77). C18E9.4 C18E9.4 Protein of unknown function C18E9.5 C18E9.5 Protein of unknown function C18E9.6 C18E9.6 Protein of unknown function, has high similarity to uncharacterized human TOMM40 C18E9.7 C18E9.7 Protein containing three fibronectin type III domains, which are involved in cell surface binding protein-tyrosine phosphatase like C18E9.8 C18E9.8 Protein of unknown function C18E9.8 is orthologous to the human gene JOINED TO JAZF1 (JJAZ1; OMIM:606245), which when mutated leads to disease. C18E9.9 C18E9.9 Protein of unknown function C18F10.2 C18F10.2 Protein containing a major sperm protein (MSP) domain, which are involved in sperm motility C18F10.4 srg-1;C18F10.4 G protein-coupled receptor, probably involved in chemosensation by sensory amphid neurons, no homolog found in human or D. melanogaster 7TM chemoreceptor, srg family C18F10.5 srg-2;C18F10.5 G protein-coupled receptor, probably involved in chemosensation by sensory amphid neurons, no homolog found in human or D. melanogaster 7TM chemoreceptor, srg family C18F10.6 srg-3;C18F10.6 G protein-coupled receptor, probably involved in chemosensation by sensory amphid neurons, no homolog found in human or D. melanogaster 7TM chemoreceptor, srg family C18F10.7 C18F10.7 Protein containing two ubiquitin interaction motifs and two ankyrin (Ank) repeats, which may mediate protein-protein interactions, has low similarity to uncharacterized human DKFZP566D1346 C18F10.8 srg-7;C18F10.8 G protein-coupled receptor, probably involved in chemosensation by sensory amphid neurons, no homolog found in human or D. melanogaster 7TM chemoreceptor, srg family C18F3.2 lad-1;C18F3.2 Member of the L1 family of cell adhesion molecules (L1CAMs); involved in embryonic and gonadal morphogenesis neural adhesion protein; sax-7 encodes the C. elegans ortholog of L1CAM; SAX-7 is ubiquitously expressed at sites of cell-cell contact, and is required for germline development, embryonic morphogenesis, and gonadal morphogenesis; SAX-7 interacts physically with the ankyrin UNC-44, and nonphosphorylated SAX-7 is colocalized with UNC-44 at sites of cellular contact in vivo. C18G1.1 C18G1.1 Protein of unknown function C18G1.2 C18G1.2 Protein containing a GATA-type zinc finger domain, has low similarity to a region of C. elegans ELT-3, which is a GATA-binding factor required for hypodermal cell differentiation GATA transcription factor C18G1.3 C18G1.3 Protein of unknown function, has high similarity to uncharacterized C. elegans F56H6.6 C18G1.4 C18G1.4 Protein of unknown function, has high similarity to uncharacterized C. elegans PGL-1, which is predicted to be a component of P granules that binds RNA C18G1.5 H1.4;C18G1.5 Histone H1 histone H1 C18G1.6 C18G1.6 Protein of unknown function, has high similarity to uncharacterized C. elegans E03H4.5 C18G1.7 C18G1.7 Protein of unknown function, has moderate similarity to uncharacterized C. elegans F39G3.2 C18G1.8 C18G1.8 Member of the glycosyl transferase family 11, which hydrolyze the glycosidic bond between two or more carbohydrates, has high similarity to uncharacterized C. elegans C14C6.3 C18G1.9 C18G1.9 Protein of unknown function, has strong similarity to uncharacterized C. elegans C14C11.1 C18H2.1 C18H2.1 Protein containing four WSN domains of unknown function, four ankyrin (Ank) repeats, which may mediate protein-protein interactions, and four BRCA1 (breast cancer type 1) C terminus (BRCT) domains, which are found in some cell cycle checkpoint proteins C18H2.2 C18H2.2 Protein of unknown function, has high similarity to uncharacterized C. elegans K06B9.4 C18H2.3 C18H2.3 Protein containing four ankyrin (Ank) repeats, which may mediate protein-protein interactions, three BRCA1 (breast cancer type 1) C terminus (BRCT) domains, which are found in some cell cycle checkpoint proteins, and two WSN domains of unknown function C18H2.4 C18H2.4 Protein containing two BRCA1 (breast cancer type 1) C terminus (BRCT) domains, which are found in some cell cycle checkpoint proteins and one WSN domain of unknown function, has low similarity to uncharacterized C. elegans F37A4.4 C18H2.4 is orthologous to the human gene GLOMULIN (FAP48; OMIM:601749), which when mutated leads to disease. C18H7.1 C18H7.1 Protein containing two von Willebrand factor (vWF) type A domains, has weak similarity to matrilin 1 (cartilage matrix protein, mouse Matn1), which is a putative component of the extracellular matrix that forms homodimers and binds collagen and aggrecan C18H7.2 C18H7.2 Protein with high similarity to C. elegans UNC-7, which is required in motor neurons for coordinated locomotion, member of the integral membrane innexin family, which are involved in the formation of gap junctions inx-18 encodes a predicted member of the innexin family. C18H7.3 C18H7.3 Protein containing two collagen triple helix repeats, which are found in some extracellular proteins and a nematode cuticle collagen N-terminal domain, has moderate similarity to a region of alpha 1 subunit of type XI collagen (human COL11A1) cuticular collagen C18H7.4 C18H7.4 Protein containing a Src homology 2 (SH2) and protein kinase domain, has low similarity to fer tyrosine kinase (mouse Fert2), which may play roles in cytoskeletal reorganization and regulation of nuclear suppressive activities during the cell cycle protein kinase C18H7.5 C18H7.5 Protein of unknown function C18H7.6 C18H7.6 Protein of unknown function C18H7.7 C18H7.7 Protein of unknown function, has moderate similarity to uncharacterized C. elegans R102.8 C18H7.8 C18H7.8 Protein containing a DUF32 domain of unknown function, has weak similarity to uncharacterized C. elegans Y41E3.15 7TM chemoreceptor, srt family C18H7.9 C18H7.9 Protein with strong similarity to C. elegans C23H5.1 gene product C18H9.1 C18H9.1 Protein of unknown function Initiation factor (IF-2) C18H9.2 C18H9.2 Protein of unknown function C18H9.3 C18H9.3 Protein containing a GYF (glycine, tyrosine, phenylalanine) domain, which are proline-binding domains C18H9.5 C18H9.5 Member of the sugar (and other) transporter family, has low similarity to solute carrier family 17 member 1 (human SLC17A1), which is involved in sodium-dependent phosphate transport and mediates organic anion transport at the renal apical membrane sodium/phosphate transport protein C18H9.6 C18H9.6 Protein of unknown function, has weak similarity to C. elegans T19D12.1 C18H9.7 C18H9.7 Protein containing a C3HC4 type (RING) zinc finger, has low similarity to receptor-associated protein of the synapse (mouse Rapsn), which is associated with acetylcholine receptors and required for agrin (Agrn) signaling through the MuSK complex postsynaptic protein; rpy-1 is orthologous to the human gene 43KDA ACETYLCHOLINE RECEPTOR-ASSOCIATED PROTEIN (RAPSN; OMIM:601592), which when mutated leads to congenital myasthenic syndrome. C18H9.8 C18H9.8 Putative coiled-coil protein, has weak similarity to myosin heavy chains C23F12.1 C23F12.1 Member of an uncharacterized protein family C23F12.2 C23F12.2 Protein with similarity to human FLNC gene product (see BLAST), gamma filamin C (actin-binding protein-280) actin-binding C23F12.3 C23F12.3 Protein of unknown function C23F12.4 C23F12.4 Protein of unknown function C23G10.1 C23G10.1 Member of the protein phosphatase protein family Protein phosphatase C23G10.10 C23G10.10 Protein of unknown function C23G10.11 C23G10.11 Protein of unknown function C23G10.2 C23G10.2 Member of the YjgF family, which may be a ligand activated enzyme, has low similarity to S. cerevisiae Mmf1p, which is a protein important for maintenance of mitochondrial DNA that may also be involved in isoleucine-dependent transaminase activity C23G10.3 C23G10.3 Member of the ribosomal protein S3 protein family, has a possible KH domain Ribosomal protein S3; rps-3 encodes a small ribosomal subunit S3 protein that contains a KH RNA-binding domain and by homology,is predicted to function in protein biosynthesis; in C. elegans, RPS-3 activity is required for embryonic and germline development, as well as the overall health of the animal. C23G10.4 rpn-2;C23G10.4 Protein containing eleven proteasome or cyclosome repeat domains, has low similarity to S. cerevisiae Rpn2p, which is a non-ATPase component of the 26S proteasome complex and functions in RNA polymerase II transcription elongation tRNA processing protein SEN3; rpn-2 encodes a non-ATPase subunit of the 26S proteasome's 19S regulatory paritcle (RP) base subcomplex; RPN-2 is required for embryonic, larval, and germline development and by homology, is predicted to function in unfolding and recognition of protein substrates and/or recycling of ubiquitin moieties during protein degradation; RPN-2 is expressed sporadically at all stages of development in the pharynx, intestine, body wall muscle, somatic gonad, neurons, and hypodermis. C23G10.5 C23G10.5 Protein of unknown function, has weak similarity to C. elegans R11D1.2 C23G10.6 C23G10.6 Protein containing two UDP-glucoronosyl and UDP-glucosyl transferase domains, has low similarity to olfactory UDP-glucuronosyltransferase (human UGT2A1), which catalyzes the glucuronidation of substrates such as odorants, steroids, drugs, and carcinogens UDP-glucosyltransferase C23G10.7 C23G10.7 Protein of unknown function C23G10.8 C23G10.8 Putative ortholog of C. elegans C23G10.9 gene product S. pombe adenylyl cyclase-associated protein (weak) C23H3.1 egl-26;egl-48;C23H3.1 Required for vulval morphogenesis egl-26 encodes a novel protein that contains an H-box/NC domain that is highly conserved with CBP01801 in C. briggsae and is required for embryonic and larval viability, egg-laying, fertility, and affects the connection of the uterus to the vulva; required in the primary vulval lineage for vulF morphogenesis and is expressed in many cells, but is expressed near the vulva and uterus only during the L4 larval stage. C23H3.2 C23H3.2 Protein of unknown function C23H3.3 C23H3.3 Protein containing a KH domain, which may bind RNA C23H3.4 C23H3.4 Protein with high similarity to serine palmitoyltransferase long chain base subunit 1 (mouse Sptlc1), which catalyzes the first step in ceramide synthesis and acts in sphingolipid metabolism, contains an aminotransferase class I and II domain aminotransferase; C23H3.4 encodes a putative serine palmitoyltransferase required for normal embryonic and larval developement, locomotion, and speed of growth. C23H3.5 C23H3.5 Protein of unknown function C23H3.9 C23H3.9 Member of the metallo-beta-lactamase family C23H4.1 cab-1;C23H4.1 Component of a neuronal transmission pathway that affects defecation and dauer larval mobility Novel protein which has a C-terminal motif weakly homologous to mouse NPDC-1 and is involved in syaptic regulation; it is expressed in various neurons including ventral cord and tail ganglion neurons; it physically interacts with AEX-3, which is a guanine nucleotide exchange factor for the Rab3 GTPase. C23H4.2 C23H4.2 Member of the carboxylesterase type B family, has low similarity to esterase 22 (egasyn, mouse Es22), which is an esterase of the nonspecific carboxylesterase family that has a role in retaining beta-glucuronidase in the endoplasmic reticulum carboxyesterase C23H4.3 C23H4.3 Member of the carboxylesterase type B family, has a region of low similarity to esterase 22 (egasyn, mouse Es22), which is an esterase with a role in retaining beta-glucuronidase in the endoplasmic reticulum carboxyesterase C23H4.4 C23H4.4 Member of the carboxylesterase type B family, has low similarity to carboxylesterase-related protein (human PCE3), which hydrolyzes esters, amides and thioesters and is involved in the metabolism of drugs and endogenous and foreign toxicants carboxyesterase C23H4.5 C23H4.5 Putative ortholog of C. elegans E01G6.3 gene product C23H4.6 C23H4.6 Putative coiled-coil protein, has strong similarity to S. cerevisiae Rhc18p, a protein involved in recombination repair Yeast RAD18 protein like C23H5.1 C23H5.1 Protein with strong similarity to C. elegans C18H7.9 gene product C23H5.2 C23H5.2 Protein of unknown function, has weak similarity to C. elegans Y119D3_465.P globin C23H5.3 C23H5.3 Protein of unknown function C23H5.7 C23H5.7 Member of the cyclic nucleotide gated ion channel protein family cyclic nucleotide-binding protein C23H5.8 C23H5.8 Protein of unknown function C23H5.9 C23H5.9 Protein of unknown function containing a Ground-like domain, has weak similarity to C. elegans Y75B8A.W C24A1.1 C24A1.1 Protein of unknown function C24A1.2 C24A1.2 Protein containing an ETS domain, which bind promoter DNA, has a region of moderate similarity to a region of new Ets related factor 2 (E74-like factor 2) human ELF2, which is an ETS transcriptional activator C24A1.3 C24A1.3 Protein containing a protein kinase domain and nine ankyrin (Ank) repeats, which may mediate protein-protein interactions, has a region of moderate similarity to a region of mixed lineage kinase with a leucine zipper and a sterile alpha motif (human ZAK) C24A1.4 C24A1.4 Member of the transposase family, which are required for excising and inserting mobile genetic elements transposase C24A11.1 C24A11.1 Protein with moderate similarity to C. elegans F37A8.2 gene product C24A11.2 C24A11.2 Protein containing a FERM domain (Band 4.1 family), which link cytoplasmic proteins to membranes, has weak similarity to erythrocyte membrane protein band 4.1 (human EPB41), which has a role in maintaining cell shape C24A11.5 C24A11.5 Protein of unknown function C24A11.6 C24A11.6 Protein of unknown function C24A11.8 C24A11.8 Protein of unknown function, has high similarity to C. elegans C24A11.2 frm-4 encodes a predicted transmembrane protein that contains an N-terminal FERM (Band 4.1-ezrin-radixin-moesin) domain; by homology, FRM-4 is predicted to function as a membrane-cytoskeleton linker protein that plays a role in cell adhesion, migration, or organization of cell surface structures; however, as loss of frm-4 activity via large-scale RNAi screens does not result in any obvious abnormalities, the precise role of FRM-4 in C. elegans development and/or behavior is not yet known. C24A11.9 C24A11.9 Member of the polyprenyl synthetase family, which function in isoprenoid biosynthesis, has low similarity to hexaprenyl pyrophosphate synthetase (S. cerevisiae Coq1p), which catalyzes the first step in coenzyme Q (ubiquinone) biosynthesis pathway hexaprenyl pyrophosphate synthetase C24A3.1 C24A3.1 Protein with strong similarity to C. elegans M03A1.5 gene product Neuropeptide anthorfamide C24A3.2 C24A3.2 Protein of unknown function, has weak similarity to C. elegans B0464.3 C24A3.4 C24A3.4 Member of the CAIB or BAIF family of diverse enzymes, has a region of moderate similarity to alpha-methylacyl-CoA racemase (mouse Amacr), which mediates for isomerization of alpha-methyl-branched fatty acids and has role in lipid metabolism E. coli L-carnitine dehydratase C24A3.5 twk-2;C24A3.6;C24A3.5 Member of the 4 TM potassium channel protein family C24A3.7 C24A3.7 Member of the reverse transcriptase protein family, which are RNA-dependent DNA polymerases, has very strong similarity to uncharacterized C. elegans F28E10.3 reverse transcriptase C24A3.8 C24A3.8 Protein with strong similarity to C. elegans F31A9.1 gene product C24A8.1 C24A8.1 Member of the rhodopsin family of G protein-coupled receptors (GPCR), has low similarity to dopamine D2 receptor (mouse Drd2), which inhibits adenylyl cyclase and glutamaterigic neurotransmission and is important for locomotory behavior G-protein coupled receptor C24A8.3 C24A8.3 Protein of unknown function, has a region of low similarity to a region of nuclear receptor coactivator 6 (mouse Ncoa6), which interacts with basal factors, transcription integrators, and ligand-dependent nuclear receptors to activate transcription The protein product of this gene is predicted to contain a glutamine/asparagine (Q/N)-rich ('prion') domain, by the algorithm of Michelitsch and Weissman (as of the WS77 release of WormBase, i.e., in wormpep77). C24A8.4 C24A8.4 Member of the rhodopsin family of G protein-coupled receptors (GPCR), has a region of high similarity to yeast Sps1Ste20-related kinase 3 (mouse Stk4), which a protein kinase that may function in apoptosis G-protein coupled receptor C24A8.5 C24A8.5 Protein of unknown function C24B5.1 C24B5.1 Member of the rhodopsin family of G protein-coupled receptors (GPCR), has low similarity to uncharacterized C. elegans F16C3.1 C24B5.2 C24B5.2 Member of the proteasome complex protein family ATPase C24B5.3 ptr-1;C24B5.3 Member of the patched family, which are transmembrane receptors, has weak similarity to Niemann-Pick disease type C1 (human NPC1), which is a lysosomal protein that plays a role cholesterol transport C24B5.4 C24B5.4 Protein of unknown function C24B5.5 C24B5.5 Protein with moderate similarity to C. elegans M02G9.1 gene product The protein product of this gene is predicted to contain a glutamine/asparagine (Q/N)-rich ('prion') domain, by the algorithm of Michelitsch and Weissman (as of the WS77 release of WormBase, i.e., in wormpep77). C24B9.1 C24B9.1 Member of the 7-transmembrane chemoreceptor family of G protein-coupled receptors (GPCR), has low similarity to C. elegans ODR-10, which is a G protein-coupled receptor involved in odorant response 7TM chemoreceptor, str family C24B9.10 C24B9.10 Protein of unknown function, has moderate similarity to uncharacterized C. elegans C24B9.7 7TM chemoreceptor, srg family C24B9.11 C24B9.11 Protein of unknown function, has high similarity to uncharacterized C. elegans ZC317.5 7TM chemoreceptor, srg family C24B9.12 C24B9.12 Protein of unknown function, has high similarity to uncharacterized C. elegans ZK678.6 7TM chemoreceptor, srg family C24B9.13 C24B9.13 Protein of unknown function, has moderate similarity to uncharacterized C. elegans F41H8.3 C24B9.2 C24B9.2 Protein containing a DUF32 domain of unknown function, has high similarity to uncharacterized C. elegans C16D9.7 7TM chemoreceptor, srt family C24B9.3 C24B9.3 Protein containing a von Willebrand factor (vWF) type A domain C24B9.4 C24B9.4 Protein containing a DUF32 domain of unknown function, has high similarity to uncharacterized C. elegans C24B9.6 7TM chemoreceptor, srt family C24B9.5 C24B9.5 Protein containing a DUF32 domain of unknown function, has high similarity to uncharacterized C. elegans R08F11.2 7TM chemoreceptor, srt family C24B9.6 C24B9.6 Protein containing a DUF32 domain of unknown function, has high similarity to uncharacterized C. elegans C24B9.4 7TM chemoreceptor, srt family C24B9.7 C24B9.7 Protein of unknown function, has moderate similarity to uncharacterized C. elegans C24B9.10 7TM chemoreceptor, srg family C24B9.8 C24B9.8 Member of the 7-transmembrane chemoreceptor family of G protein-coupled receptors (GPCR), has low similarity to C. elegans ODR-10, which is involved in odorant response 7TM chemoreceptor, str family C24B9.9 C24B9.9 Protein with strong similarity to C. elegans T04C12.1 gene product C24D10.1 C24D10.1 Member of the protein-tyrosine phosphatase family, which are involved in control of cell growth, proliferation, differentiation and transformation, has high similarity to uncharacterized C. elegans Y57G11C.6 C24D10.2 C24D10.2 Protein of unknown function, has strong similarity to uncharacterized C. elegans F11G11.4 C24D10.4 C24D10.4 Protein of unknown function C24D10.5 C24D10.5 Protein of unknown function, has high similarity to uncharacterized C. elegans T11F8.1 C24D10.6 C24D10.6 Protein of unknown function C24D10.7 C24D10.7 Protein of unknown function C24D10.8 C24D10.8 Protein of unknown function C24F3.1 C24F3.1 Protein with moderate similarity to translocating chain-associating membrane protein (human TRAM), which is a putative endoplasmic reticulum receptor that stimulates translocation of secretory proteins C24F3.2 C24F3.2 Protein containing a dual specificity phosphatase catalytic domain, has low similarity to rat Dusp12, which is a dual specificity phosphatase that binds to glucokinase (Gck) and stimulates its activity Dual specificity phosphatase, catalytic domain C24F3.3 C24F3.3 Member of the astacin (M12A) family of metalloproteases, has a region of moderate similarity to a region of tolloid-like 2 (human TLL2), which processes the extracellular matrix crosslinking prolysyl oxidase (human LOX) zinc metallopeptidase (M12A family) C24F3.4 C24F3.4 Member of the eukaryotic NAD synthetase branch in the nitrilase superfamily, which also includes human FLJ10631, S. cerevisiae Qns1p and S. pombe SPBC23E6.03cp that play a role in utilization of glutamine as an ammonia source C24F3.5 C24F3.5 Member of the ABC transporter family, which are involved in translocation across biological membranes, has a region of weak similarity to a region of ATP-binding cassette subfamily A member 4 (mouse Abca4), which is involved in visual dark adaptation ABC transporters C24F3.6 C24F3.6 Protein with high similarity to C. elegans SQT-3, contains two collagen triple helix repeats, which are found in some extracellular proteins, and a nematode cuticle collagen N-terminal domain CUTICLE COLLAGEN 1 C24G6.1 C24G6.1 Protein of unknown function C24G6.2 C24G6.2 Protein containing two protein kinase domains and one fibronectin type III domain, which are involved in cell surface binding, has a region of moderate similarity to a region of fibroblast growth factor receptor 1 (mouse Fgfr1) protein kinase C24G6.3 C24G6.3 Protein of unknown function, has a region of low similarity to a region of human MMS19L, which may play a role in both repair and transcription by interacting with the XPB and XPD subunits of the nucleotide excision repair transcription factor human TFIIH C24G6.4 csr-1;nhr-47;C24G6.4 Putative nuclear hormone receptor, has strong similarity to C. elegans R09G11.2, has similarity to human and D. melanogaster HNF4 hepatocyte nuclear factors zinc finger protein C24G6.5 C24G6.5 Protein containing one DnaJ domain and one cysteine-rich DnaJ central domain, has high similarity to a region of dnaJ homolog member 2 of subfamily A (human DNAJA2), which is a cochaperone associated with cancer cell growth inhibition when upregulated This gene encodes a protein containing a DnaJ ('J') domain. C24G6.6 C24G6.6 Member of the flavin containing amine oxidase family, has low similarity to uncharacterized C. elegans F25C8.2 C24G6.7 C24G6.7 Protein of unknown function containing a Ground-like domain, has moderate similarity to C. elegans F42C5.7 C24G6.8 C24G6.8 Protein containing a a UBA (ubiquitin associated) or TS-N domain and a UPF0099 domain of unknown function C24G7.1 C24G7.1 Member of the amiloride-sensitive sodium channel family, has similarity to human and D. melanogaster amiloride-sensitive cation channels C24G7.2 C24G7.2 Member of the amiloride-sensitive sodium channel family, has similarity to human and D. melanogaster amiloride-sensitive cation channels C24G7.3 C24G7.3 Protein of unknown function, has low similarity to uncharacterized C. elegans ZC53.3 mariner transposase C24G7.4 C24G7.4 Member of the amiloride-sensitive sodium channel family, has similarity to human and D. melanogaster amiloride-sensitive cation channels C24G7.5 C24G7.5 Putative muscle protein, member of Ig superfamily C24H10.1 C24H10.1 Protein of unknown function, has low similarity to uncharacterized C. elegans R04F11.1 C24H10.1 encodes a claudin homolog that may be required for normal cohesion of apical junctions in epithelia; C24H10.1 is worm-specific, with obvious homologs only in C. elegans; C24H10.1 has no obvious function in mass RNAi assays; claudins are integral membrane proteins with four transmembrane sequences that are found in mammalian tight junctions (TJs), induce TJs when transgenically expressed in cells normally lacking them, and can mediate the specific conductance of of specific ions (e.g., magnesium or calcium) through TJs while blocking the flow of water. C24H10.2 C24H10.2 Protein of unknown function C24H10.3 C24H10.3 Protein of unknown function C24H10.4 C24H10.4 Protein of unknown function C24H10.5 uvt-2;C24H10.5 Protein containing four EF hand domains, which are found in signaling, buffering or transport proteins, has moderate similarity to calmodulin 1 (mouse Calm1), which is involved in regulation of calcium-dependent activity of proteins and enzymes EF-hand calcium binding protein; uvt-2 encodes a protein that contains four EF-hand calcium binding motifs with similarity to human calmodulin; mRNA weakly expressed in L1 through L4 larval stages and in the adult hermaphrodite. | uvt-2 encodes a protein that contains four EF-hand calcium binding motifs with some similarity to human calmodulin; mRNA weakly expressed in L1 through L4 larval stages and in the adult hermaphrodite. C24H11.1 C24H11.1 Member of the serine or threonine protein phosphatase family, has moderate similarity to serine-threonine protein phosphatase PP1-2 minor type (S. pombe Sds21p) Protein phosphatase-1 (PP1) C24H11.2 C24H11.2 Member of the serine or threonine protein phosphatase family, has moderate similarity to S. pombe Sds21, which is a minor type serine-threonine protein phosphatase Protein phosphatase-1 (PP1) C24H11.3 C24H11.3 Protein containing a T-box domain, which bind DNA, has a region of moderate similarity to a region of t-box 6 (human TBX6), which is a DNA-binding protein that may be involved in embryonic paraxial mesoderm formation and somitogenesis T-box C24H11.4 C24H11.4 Protein of unknown function, has low similarity to uncharacterized C. elegans Y45G12C.9 C24H11.5 C24H11.5 Protein of unknown function C24H11.6 C24H11.6;CeSrb7 Member of the signal peptidases type I family, has a region of moderate similarity to suppressor of RNA polymerase B7 (human SURB7), which is a component of both an RNA polymerase II holoenzyme and a transcriptional regulation complex C24H11.7 C24H11.7 Protein containing a Sec7 domain which are found in guanine nucleotide exchange factors for ARF family GTPases, has a region of weak similarity to S. cerevisiae Gea2p, which is a component of a complex with guanine-nucleotide-exchange activity for ARF This gene encodes a protein predicted by Eisenberg and coworkers, with 52% accuracy, to be mitochondrial. C24H11.8 C24H11.8 Member of the ion transport family, which include calcium, sodium, and potassium channels, has a region of low similarity to a region of potassium channel subfamily K member 2 (mouse Kcnk2) C24H12.1 C24H12.1 Protein containing an F-box domain, which serve as a link between a target protein and a ubiquitin-conjugating enzyme This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins; its encoded protein also contains a Pfam-B45 motif of presently unknown function. C24H12.10 C24H12.10 Protein containing an F-box domain, which serve as a link between a target protein and a ubiquitin-conjugating enzyme This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins. C24H12.11 C24H12.11 Protein containing an F-box domain, which serve as a link between a target protein and a ubiquitin-conjugating enzyme, has high similarity to uncharacterized C. elegans T27A1.2 This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins; its encoded protein also contains a Pfam-B45 motif of presently unknown function. C24H12.2 C24H12.2 Putative ortholog of C. elegans C24H12.5 gene product C24H12.4 C24H12.4 Member of the DEAD or DEAH box ATP-dependent RNA helicase family and contains two helicase conserved C-terminal domains, has moderate similarity to nucleolar RNA helicase 61 (human NOH61), which may function in ribosome synthesis helicase C24H12.5 C24H12.5 Putative ortholog of C. elegans C24H12.2 gene product C24H12.6 C24H12.6 Protein of unknown function C24H12.7 C24H12.7 Protein containing an F-box domain, which serve as a link between a target protein and a ubiquitin-conjugating enzyme This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins. C24H12.8 C24H12.8 Protein containing an F-box domain, which serve as a link between a target protein and a ubiquitin-conjugating enzyme, has high similarity to uncharacterized C. elegans T27A1.3 This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins. C24H12.9 C24H12.9 Protein of unknown function, has high similarity to uncharacterized C. elegans Y73E7A.5 C25A1.1 C25A1.1 Protein of unknown function C25A1.10 dao-5;C25A1.10 Protein with low similarity to nucleolar phosphoprotein 140 (rat Nopp140), which is a transcription co-activator that interacts with rat Gtf2b and rat Cebpb, shuttles between the cytoplasm and nucleolus, and may act as a nuclear import or export chaperone dao-5 encodes a predicted nucleolar phosphoprotein related to Saccharomyces cerevisiae SRP40 and the vertebrate Nopp140 proteins that may play a role in rRNA gene transcription and nucleolar structural organization; dao-5 expression is negatively regulated by the DAF-2/insulin-like receptor and positively regulated by the DAF-16/fork-head transcription factor, suggesting that dao-5 may be involved in life-span determination; dao-5 is strongly expressed in dauer larvae. C25A1.11 aha-1;C25A1.11 Putative aryl-hydrocarbon receptor nuclear translocator; member of the basic helix-loop-helix DNA-binding domain family aryl hydrocarbon receptor nuclear translocator; aha-1 encodes an ortholog of human aryl-hydrocarbon receptor nuclear translocator; interacts with AHR-1 and HIF-1 in vitro, requires HIF-1 for proper localization, and is expressed ubiquitously. C25A1.12 C25A1.12 Protein of unknown function, has moderate similarity to uncharacterized human FLJ12816 C25A1.13 C25A1.13 Protein with weak similarity to human NDUFA2 , a subunit of NADH-ubiquinone oxidoreductase NADH-ubiquinone oxidoreductase B8 subunit C25A1.15 C25A1.15 Protein of unknown function C25A1.2 C25A1.2 Protein containing a fork head domain, which are found in transcription factors involved in cell fate determination, has a region of high similarity to a region of C. elegans UNC-130, which is a transcription factor nuclear factor 5 like; fkh-10 encodes one of 15 forkhead transcriptional regulators encoded by the C. elegans genome; by homology, FKH-10 is predicted to function as a transcription factor that regulates gene expression during development; however, as loss of fkh-10 activity via RNA-mediated interference (RNAi) does not result in any obvious abnormalities, the precise role of FKH-10 in C. elegans development and/or behavior is not yet known; nevertheless, reporter gene studies indicate that throughout larval and adult stages, fkh-10 expression is detected almost exclusively in six pairs of neuronal nuclei near the terminal bulb of the pharynx, suggesting that FKH-10 may have a specific function in neuronal differentiation. C25A1.3 C25A1.3 Putative mRNA cap methyltransferase, has strong similarity to human and yeast mRNA cap methyltransferases Yeast ABD1 protein like C25A1.4 C25A1.4 Protein containing three RNA recognition motifs (RRM, RBD, or RNP), has low similarity to myocyte-specific enhancer-binding factor (human MEF-2), which interacts with muscle-specific enhancers to regulate transcription and likely myoblast differentiation RNA binding protein C25A1.5 C25A1.5 Protein with low similarity to S. cerevisiae Scs7p, which is a ceramide hydroxylase that hydroxylates the C-26 fatty-acyl moiety of inositol-phosphorylceramide Yeast hypothetical 44.9 KD protein like C25A1.6 C25A1.6 Protein with high similarity to S. cerevisiae Nop10p, which is a nucleolar protein component of box H/ACA small nucleolar RNAs (snoRNAs) which direct rRNA pseudouridinylation C25A1.7 C25A1.7 Member of the class I isoleucyl, leucyl, valyl, and methionyl (I, L, M, and V) tRNA synthetase family, has low similarity to mitochondrial isoleucyl-tRNA synthetase (S. cerevisiae Ism1p) isoleucyl-tRNA synthetase (mitochondrial); irs-2 encodes a predicted mitochondrial isoleucyl-tRNA synthetase (IleRS), a class I aminoacyl-tRNA synthetase that catalyzes the attachment of isoleucine to its cognate tRNA and is thus required for protein biosynthesis; loss of irs-2 activity via RNA-mediated interference (RNAi) does not result in any abnormalities, suggesting possible functional redundancy with irs-1. C25A1.8 C25A1.8 Member of the C-type lectin family lectin C25A1.9 C25A1.9 Protein of unknown function C25A11.1 C25A11.1 Protein of unknown function, has high similarity to uncharacterized C. elegans C25A11.2 C25A11.2 C25A11.2 Protein containing a BTB (BR-C, ttk and babor) or POZ (Pox virus and zinc finger) domain, which are found in some DNA and actin binding proteins and may mediate protein-protein interactions, has high similarity to uncharacterized C. elegans C25A11.1 C25A11.3 ajm-1;jam-1;C25A11.4;C25A11.3 Localized to the apical zonula adherens encircling the epithelium of C. elegans; recognized by monoclonal antibody MH27 which stains gap junctions C25A6.B C25A6.1;C25A6.B Member of the protein phosphatase protein family C25A8.1 C25A8.1 Protein with similarity to members of the major sperm-specific protein (MSP) family, small protein (37 amino acids) with near identity to the N-terminal region of MSP proteins truncated MSP C25A8.2 C25A8.2 Protein of unknown function, has high similarity to uncharacterized C. elegans R02D5.7 C25A8.4 C25A8.4 Member of the glycosyl hydrolase 18 family, has a region of weak similarity to chitinase 1 (chitotriosidase, human CHIT1), which catalyzes the hydrolysis of chitin and is associated with Gaucher disease and chitotriosidase deficiency C25A8.5 C25A8.5 Protein containing a Src homology 2 (SH2) domain and a protein kinase domain, has moderate similarity to fer (fps/fes related) tyrosine kinase (mouse Fert2), which may mediate cell-cell signaling and play roles in cytoskeletal reorganization protein-tyrosine kinase C25B8.1 klq-1;C25B8.1;nKQT1 Putative KQT potassium channel, putative ortholog of human potassium voltage-gated channel KCNQ3 voltage-gated potassium channel; The kqt-1 gene encodes a homolog of human KCNQ2, which when mutated leads to benign familial neonatal convulsions (OMIM:121200). C25B8.3 cpr-6;C25B8.3 Member of the Cathepsin B-like Cysteine Protease family C25B8.4 C25B8.4 Member of the lectin protein family, putative paralog of C. elegans C25A1.8 asialoglycoprotein receptor C25B8.5 C25B8.5 Member of the rhodopsin family of G protein-coupled receptors (GPCR), has low similarity to uncharacterized C. elegans C48C5.3 alpha adrenergic receptor C25B8.6 C25B8.6 Protein containing a nuclear hormone receptor C4-type zinc finger domain and a nuclear hormone receptor ligand-binding domain, has weak similarity to retinoid X receptor alpha (mouse Rxra), which is a high affinity receptor for 9-cis retinoic acid C25D7.1 C25D7.1 Protein containing a major sperm protein (MSP) domain, which are involved in sperm motility, has high similarity to uncharacterized C. elegans K07F5.7 C25D7.10 C25D7.10 Protein contains a putative DnaJ domain, putative paralog of C. elegans C01G10.12 protein C25D7.12 C25D7.12 Protein containing a major sperm protein (MSP) domain, which are involved in sperm motility, has strong similarity to uncharacterized C. elegans C25D7.2 C25D7.2 C25D7.2 Protein containing a major sperm protein (MSP) domain, which are involved in sperm motility, has strong similarity to uncharacterized C. elegans C25D7.12 C25D7.3 sdc-3;dpy-29;C25D7.3 Zinc finger protein required for sex determination and dosage compensation Zinc finger, C2H2 type; sdc-3 encodes a protein that contains two mutationally separable domains: a zinc finger motif required for dosage compensation and a myosin- like putative ATP- binding region required for her-1 regulation of sex determination; SDC-3 activates dosage compensation by directing the dosage compensation protein complex to the hermaphrodite X chromosomes, and is functionally redundant with SDC-2 with respect to dosage compensation; SDC-1, SDC-2, and SDC-3 proteins form a complex. C25D7.4 C25D7.4 Protein containing a DUF38 domain of unknown function and an F-box domain, which serve as a link between a target protein and a ubiquitin-conjugating enzyme, has low similarity to C. elegans FOG-2, which is required for the sexual identity of germ cells This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins; this gene's encoded protein also contains an FTH/DUF38 motif, which may also mediate protein-protein interaction. C25D7.5 C25D7.5 Protein of unknown function, has weak similarity to C. elegans C03F11.2 C25D7.6 C25D7.6 Protein with high similarity to minichromosome maintenance deficient 3 (human MCM3), which associates with the DNA polymerase alpha-primase complex and is involved in initiation of DNA replication, member of the MCM family of DNA-dependent ATPases DNA replication licensing factor MCM3; mcm-3 encodes a member of the MCM2/3/5 family with similarity to human DNA replication licensing factor, MCM3, and affects embryonic viability. C25D7.7 C25D7.7 Protein with high similarity to human RAP2B, which translocates to the cytoskeleton in platelets stimulated with von Willebrand factor (human VWF), member of the Ras superfamily of GTP binding proteins RAS-related protein; rap-2 encodes a Ras-related GTPase that is most similar to the RAP2 members of the Ras GTPase superfamily; by homology, RAP-2 is predicted to function as a membrane-localized GTPase that likely plays a role in signal transduction; as animals homozygous for a rap-2 deletion mutation show no obvious abnormalities, the precise role of RAP-2 in C. elegans development and/or behavior is not yet known. C25D7.8 C25D7.8 Protein of unknown function, has low similarity to uncharacterized human FLJ20113 C25D7.9 C25D7.9 Protein of unknown function C25E10.1 C25E10.1 Protein containing a nuclear hormone receptor C4-type zinc finger domain, which bind DNA and may be involved in regulation of transcription, has low similarity to C. elegans NHR-84 zinc finger-containing protein C25E10.10 C25E10.10 Protein containing a trypsin inhibitor-like cysteine rich domain C25E10.11 C25E10.11 Protein of unknown function C25E10.12 C25E10.12 Protein of unknown function, has high similarity to uncharacterized C. elegans K07C11.7 C25E10.2 C25E10.2 Member of the cytochrome P450 family, has low similarity to cytochrome P450 2c29 (mouse Cyp2c29), which is a major cannabinoid metabolizing enzyme in liver microsomes and is involved in detoxification of xenobiotics and drugs cytochrome P450 C25E10.3 C25E10.3 Protein of unknown function, has high similarity to uncharacterized C. elegans C25E10.5 7TM chemoreceptor, srsx family C25E10.4 C25E10.4 Protein of unknown function, has high similarity to uncharacterized C. elegans C25E10.5 C25E10.5 C25E10.5 Protein of unknown function, has high similarity to uncharacterized C. elegans C25E10.4 C25E10.6 C25E10.6 Protein of unknown function C25E10.7 C25E10.7 Protein containing two trypsin inhibitor-like cysteine rich domains, has high similarity to uncharacterized C. elegans C25E10.8 C25E10.8 C25E10.8 Protein containing two trypsin inhibitor-like cysteine rich domains, has high similarity to uncharacterized C. elegans C25E10.9 C25E10.9 C25E10.9 Protein containing two trypsin inhibitor-like cysteine rich domains, has high similarity to uncharacterized C. elegans C25E10.8 C25F6.1 C25F6.1 Protein of unknown function C25F6.2 dlg-1;C25F6.2 Putative guanylate kinase required for adherens junctions assembly; strongly similar to D. melanogaster DLG1 (discs large 1) guanylate kinase; dlg-1 encodes a MAGUK protein, orthologous to Drosophila disks large, that is physically located to adherens junctions in all epithelia and that is genetically required for organization of the embryonic gut epithelium into an coherent tube. C25F6.3 C25F6.3 Protein with high similarity to dihydropyrimidine dehydrogenase (rat Dpyd), member of the pyridine nucleotide-disulphide oxidoreductase and dihydroorotate dehydrogenase families, contains two iron-sulfur cluster (4Fe-4S) binding domains The C25F6.3 gene encodes an ortholog of the human gene DIHYDROPYRIMIDINE DEHYDROGENASE (DPYD), which when mutated leads to thymine-uraciluria (OMIM:274270). C25F6.4 C25F6.4 Protein containing two protein kinase domains and an a F5 or 8 type C (discoidin) domain, has low similarity to discoidin domain receptor 2 (human DDR2), which is a receptor protein tyrosine kinase that is activated by collagen and upregulates human MMP1 Protein tyrosine kinase; The C25F6.4 gene encodes a protein tyrosine kinase homolog that is also homologous to human RS1. C25F6.6 C25F6.6 Protein of unknown function, has weak similarity to C. elegans M153.3 C25F6.7 C25F6.7 Protein of unknown function C25F9.1 C25F9.1 Putative ortholog of C. elegans Y116F11.Z gene product 7TM chemoreceptor, srw family C25F9.2 C25F9.2 Putative ortholog of C. elegans Y116F11.Y gene product C25F9.4 C25F9.4 Protein of unknown function, has strong similarity to uncharacterized C. elegans M04C3.2 C25F9.5 C25F9.5 Protein with high similarity to uncharacterized C. elegans M04C3.1, contains an SNF2 related N-terminal domain C25F9.6 C25F9.6 Protein with strong similarity to C. elegans Y116F11.V gene product C25F9.7 C25F9.7 Member of the rhodopsin family of G protein-coupled receptors (GPCR) 7TM chemoreceptor, srw family C25F9.8 C25F9.8 Putative ortholog of C. elegans F28B1.6 gene product C25F9.9 C25F9.9 Protein of unknown function, has low similarity to uncharacterized C. elegans Y43F8B.12 C25G4.1 C25G4.1 Member of the C-type lectin family Lectin C-type domain short and long forms (2 domains) C25G4.10 C25G4.10 Protein containing five fibronectin type III domains, which are involved in cell surface binding, three DB module domains, and an immunoglobulin (Ig) domain, has very strong similarity to uncharacterized C. elegans T04A11.3 fibronectin C25G4.11 C25G4.11 Protein of unknown function C25G4.2 C25G4.2 Protein of unknown function, has moderate similarity to uncharacterized human OVCA2, which is a candidate tumor suppressor that is downregulated in most ovarian tumors and tumor cell lines dihydrofolate reductase like C25G4.3 C25G4.3 Member of the ribosome-binding factor A family C25G4.4 C25G4.4 Protein containing an AT-hook motif, which preferentially binds A-T rich DNA, contains a SAND (Sp100, AIRE-1, NucP41/75 and DEAF-1/suppressin) domain, has weak similarity to a region of glucocorticoid modulatory element binding protein 1 (mouse Gmeb1) SAND domain C25G4.5 dpy-26;C25G4.5 Negative regulator of X-linked, dosage-compensated genes SDC-1, SDC-2, and SDC-3 proteins form a complex (detectable by coimmunoprecipitation); these three proteins, in turn, colocalize with DPY-26, DPY-27, and MIX-1 proteins both on a transgenic her-1(+) array and on the X chromosome. C25G4.6 C25G4.6 Protein containing two PDZ, DHR, or GLGF domains, which are found in signaling proteins, has very strong similarity to uncharacterized C. elegans T21G5.4 PDZ domain (Also known as DHR or GLGF). (2 domains) C25G4.7 C25G4.7 Protein of unknown function, has high similarity to uncharacterized C. elegans ZK973.8 C25G4.8 C25G4.8 Protein of unknown function, has high similarity to uncharacterized C. elegans Y49F6B.8 C25G6.1 C25G6.1 Protein with moderate similarity to C. elegans F35D11.1 gene product C25G6.2 C25G6.2 Member of the tetraspanin family, which contain an N-terminal transmembrane domain that is a signal sequence and membrane anchor, has low similarity to motility related protein 1 (CD9 antigen, human CD9), which mediates platelet activation and aggregation transpanin C25G6.3 C25G6.3 Member of the AMP-binding enzyme family luciferase C25G6.4 C25G6.4 Protein of unknown function C25G6.5 C25G6.5 Member of the rhodopsin family of G protein-coupled receptors (GPCR), has low similarity to neuropeptide Y-Y1 receptor (human NPY1R), which inhibits adenylyl cyclase and induces calcium flux and is associated with a wide variety of physiological processes G-protein coupled receptor (family 1) C25H3.1 C25H3.1 Putative casein kinase, has similarity to human, S. cerevisiae, and D. melanogaster casein kinases C25H3.10 C25H3.10 Protein containing an F-box domain, which serve as a link between a target protein and a ubiquitin-conjugating enzyme C25H3.11 C25H3.11 Protein with strong similarity to C. elegans T08G11.1 gene product C25H3.12 C25H3.12 Protein of unknown function C25H3.3 C25H3.3 Protein containing one uncharacterized bacterial PaaI domain C25H3.4 C25H3.4 Protein of unknown function, has low similarity to uncharacterized ligatin (human LGTN), which is a putative receptor for phosphoglycoproteins that may be involved in intracellular protein trafficking C25H3.5 C25H3.5 Protein of unknown function C25H3.6 C25H3.6 Protein of unknown function C25H3.7 C25H3.7 Protein containing a glutathione S-transferase C-terminal domain, which may be involved in conjugation of reduced glutathione to various targets C25H3.9 C25H3.9 Protein with strong similarity to S. cerevisiae Vps13p, a nonessential protein involved in vacuolar sorting C26B2.1 C26B2.1 Protein with low similarity to dynactin 4 (human DCTN4), which is a component of the dynactin complex that directly binds actin-related protein 1 (human ACTR1A) and may be involved in human ACTR1A pointed end capping C26B2.2 C26B2.2 Protein of unknown function, has strong similarity to C. elegans ZK930.7 C26B2.3 nhr-31;nhr-21;C26B2.3 Member of the nuclear hormone receptor/zinc finger protein family zinc finger protein C26B2.4 C26B2.4 Protein containing a nuclear hormone receptor ligand binding domain and a nuclear hormone receptor C-4 type zinc finger domain, has weak similarity to nuclear receptor 2F1 (human NR2F1), which regulates transcription and activates HIV gene transcription nuclear hormone receptor C26B2.5 C26B2.5 Protein of unknown function C26B2.6 C26B2.6 Protein of unknown function, has low similarity to uncharacterized human FLJ20498 C26B2.7 C26B2.7 Protein of unknown function C26B2.8 C26B2.8 Protein of unknown function, has weak similarity to C. elegans ZC84.6 C26B9.1 C26B9.1 Protein of unknown function C26B9.2 C26B9.2 Protein with strong similarity to C. elegans F35D2.2 gene product C26B9.3 C26B9.3 Protein of unknown function C26B9.5 C26B9.5 Protein with weak similarity to prolylcarboxypeptidase (angiotensinase C, human PRCP), which is a serine carboxypeptidase that catalyzes the cleavage of C-terminal amino acid residues linked to proline lysosomal Pro-X carboxypeptidase C26B9.6 C26B9.6 Protein containing a C3HC4 type (RING) zinc finger, which may mediate protein-protein interactions, and two WWE domains, which may mediate protein interactions in ubiquitin and ADP ribose conjugation systems C26B9.7 C26B9.7 Protein of unknown function C26C6.1 C26C6.1 Protein containing two high mobility group box (HMG1 or 2) family domains, ten bromodomains, which interact specifically with acetylated lysine, four C2H2 type zinc finger domains, which bind nucleic acids, and four bromo-adjacent homology (BAH) domains HMG (high mobility group) box, Bromodomain (5 domains), Zinc finger, C2H2 type; C26C6.1 encodes an ortholog of the vertebrate Polybromo proteins (e.g., human BAF180; OMIM:606083); C26C6.1 has multiple domains associated with transcriptional regulation (bromodomains, zinc-finger domains, a 'high mobility group' / HMG domain) and a glutamine/asparagine-rich domain. C26C6.2 goa-1;C26C6.2 Member of the G protein alpha subunit protein family; apparently involved in synaptic transmission; may have a role in regulating centrosome movement during early embryogenesis guanine nucleotide-binding protein; The goa-1 gene encodes an ortholog of the heterotrimeric G protein alpha subunit Go (Go/Gi class) that affects normal locomotion, egg-laying, and male mating; it genetically interacts with the egl-30 pathway, and is expressed in all neurons and sex-specific muscles. C26C6.3 C26C6.3 Member of the astacin (M12A) family of metalloproteases, contains a CUB domain and a type 1 thrombospondin domain, has low similarity to C. elegans HCH-1, which is a putative zinc-dependent metalloprotease zinc metalloprotease C26C6.4 C26C6.4 Protein of unknown function, has high similarity to uncharacterized C. elegans F28G4.4 C26C6.5 C26C6.5 Protein of unknown function C26C6.6 C26C6.6 Protein containing two LIM domains, which may mediate protein-protein interactions, has low similarity to a region of leupaxin (human LPXN), which is a putative signal transduction protein that binds focal adhesion protein tyrosine kinase PYK2 (PTK2B) lim domains C26C6.7 C26C6.7 Protein of unknown function, has weak similarity to C. elegans C18C4.8 Globin C26C6.8 C26C6.8 Protein containing a Src homology 3 (SH3) domain, which bind proline-rich peptides tyrosine-protein kinase like C26D10.1 C26D10.1 Protein containing six regulator of chromosome condensation (RCC1) repeat domains, has low similarity to regulator of chromosome condensation 1 (human CHC1), which binds chromatin and functions as a guanine nucleotide exchange factor for human RAN regulator of chromosome condensation C26D10.2 hel-1;hel;C26D10.2 Protein with high similarity to S. cerevisiae Sub2p, which is an essential pre-mRNA splicing factor, member of the DEAD or DEAH box ATP-dependent RNA helicase family and contains a helicase conserved C-terminal domain translation initiation factor eIF-4A C26D10.3 C26D10.3 Member of the pyridine nucleotide-disulphide oxidoreductase family, which are flavoproteins, has low similarity to uncharacterized human FLJ22028 oxidoreductase C26D10.4 C26D10.4 Putative ortholog of C. elegans C26D10.5 gene product C26D10.5 C26D10.5;EFF-1 Protein of unknown function, has low similarity to uncharacterized C. elegans C44B7.3 The eff-1 gene encodes a novel, type I transmembrane glycoprotein that is required for cell fusion during development; eff-1(hy21) mutants are viable, but have severe body morphology defects associated with cell fusion failure. C26D10.6 C26D10.6 Protein of unknown function C26E1.1 C26E1.1 Protein of unknown function C26E1.2 C26E1.2 Protein of unknown function, has weak similarity to human atrophin-1 related protein (DRPLA) C26E1.3 C26E1.3 Protein of unknown function C26E6.1 C26E6.1 Protein of unknown function, has low similarity to uncharacterized C. elegans C50H2.7 C26E6.11 C26E6.11 Member of the DUF80 family of unknown function C26E6.12 C26E6.12 Protein with strong similarity to C. elegans M01E5.2 gene product C26E6.2 C26E6.2 Protein with strong similarity to C. elegans Y11D7A.12 gene product C26E6.3 C26E6.3 Putative ortholog of S. cerevisiae Ynl288p, a protein of unknown function cell differentiation family, Rcd1-like C26E6.4 C26E6.4 Protein with high similarity to RNA polymerase II polypeptide b (human POLR2B), which is the second largest RNA polymerase II subunit that regulates some transcriptional coactivators including human BRCA1, member of the RNA polymerases beta subunit family DNA-directed RNA polymerase II C26E6.5 C26E6.5 Protein with strong similarity to C. elegans Y46E12BL.4 gene product C26E6.6 C26E6.6 Protein with weak similarity to ribosomal protein L3 Ribosomal protein L3; This gene encodes a protein predicted by Eisenberg and coworkers, with 52% accuracy, to be mitochondrial. C26E6.7 C26E6.7 Protein of unknown function C26E6.8 ula-1;C26E6.8 Putative NED-8 activating enzyme; ortholog of human amyloid beta precursor protein-binding protein 1 (APPBP1), a protein possibly involved in onset of Alzheimer's Disease The ula-1 gene encodes a component of the enzyme that activates NED-8, which in turn is a ubiquitin-like protein whose conjugating enzyme is UBC-12. C26E6.9 set-2;C26E6.9 Protein containing three SET domains, which are involved in protein-protein interactions, and two RNA recognition motifs (RRM, RBD, or RNP), has a region of moderate similarity to a region of S. cerevisiae Set1p, which mediates methylation of histone H3 C26F1.1 C26F1.1 Protein of unknown function C26F1.10 C26F1.10 Protein of unknown function flp-21 encodes a single FMRFamide-related neuropeptide (FaRP) that serves as a ligand for NPR-1, a G protein-coupled receptor that regulates social versus solitary feeding behavior in several Caenorhabditis species; genetic analysis suggests that FLP-21 acts through NPR-1 to inhibit social feeding behavior; FLP-21 is expressed in the ADL, ASE and ASH sensory neurons, the URA motor neurons, the MC, M2 and M4 pharyngeal neurons, and the intestine; flp-21 encodes the only FMRFamide-related neuropeptide (FaRP) encoded by the C. elegans genome that activates both the social (215F) and the solitary (215V) forms of NPR-1 in both Xenopus oocytes and pharyngeal assays. C26F1.2 C26F1.2 Member of the cytochrome P450 family, has low similarity to cytochrome P450 subfamily 4F polypeptide 6 (rat Rn.11269), which may be one of the major forms of P450 to catalyze the NADPH-dependent omega hydroxylation of fatty acids in the brain cytochrome P450 C26F1.3 C26F1.3;5I259 Protein of unknown function C26F1.4 C26F1.4 Member of the ubiquitin family, has high similarity to uncharacterized finkel-Biskis-Reilly murine sarcoma virus ribosomal protein S30 (human FAU), which is a ubiquitin-like protein formed by fusion of the genes for ribosomal protein S30 ribosomal protein/ubiquitin-like protein; rps-30 encodes two proteins, a small ribosomal subunit S30 protein and ubiquitin, which is cleaved from the ribosomal protein posttranslationally; by homology, S30 is predicted to function in protein biosynthesis and ubiquitin in protein degradation; in C. elegans, loss of rps-30 function via RNA-mediated interference (RNAi) does not result in any obvious abnormalities. C26F1.5 C26F1.5 Protein of unknown function containing a Ground-like domain, has weak similarity to C. elegans T02E9.2 C26F1.6 C26F1.6 Member of the rhodopsin family of G protein-coupled receptors (GPCR), has low similarity to neuromedin U receptor 2 (human NMU2R), which increases levels of intracellular calcium and may play a role in sensory transmission or modulation and feeding C26F1.6 encodes a homolog of the functionally active Fmrf Receptor (FR; CG2114) of D. melanogaster; it is thus possible that C26F1.6 is a receptor for one of the FMRF-like neurotransmitters in C. elegans (e.g., FLP-1 through FLP-12). C26F1.7 C26F1.7 Protein containing an N-terminal HIT (histidine triad) domain, has weak similarity over HIT domains to protein kinase C inhibitors including human HINT C26F1.9 C26F1.9;5I256 Protein with high similarity to ribosomal protein L39 (S. cerevisiae Rpl39p), which is a structural ribosomal protein, contains a ribosomal L39 domain, which are present in the large ribosomal subunit ribosomal protein L39; rpl-39 encodes a large ribosomal subunit L39 protein. C26G2.1 C26G2.1 Member of the immunoglobulin-like protein family Immunoglobulin domain ; Fibronectin type III domain; The gene C26G2.1 encodes an ortholog of human NEPHRIN (NPHS1; OMIM:602716), which when mutated leads to congenital nephrotic syndrome 1 (OMIM:256300). C26G2.2 C26G2.2 Protein with weak similarity to C. elegans F35C5.3 gene product C26G2.3 slt-1;F40E10.4;C26G2.3 Protein containing 18 leucine rich repeat, 1 extracellular laminin G, 7 epidermal growth factor (EGF)-like, 4 leucine rich repeat N-terminal cysteine rich and 4 leucine rich repeat C-terminal cysteine rich domains, has moderate similarity to human SLIT2 C26H9A.1 vha-7;C26H9A.B;C26H9A.1 Member of the vacuolar H+-ATPase protein family C26H9A.A C26H9A.2;C26H9A.A Protein of unknown function C27A12.2 C27A12.2 Protein containing seven C2H2 type zinc finger domains, which bind nucleic acids, has weak similarity to zinc finger protein 255 (human ZNF255), which is a DNA-binding Kruppel-like zinc finger protein that positively regulates transcription zinc finger protein C27A12.3 C27A12.3 Protein containing six C2H2 type zinc finger domains, which bind nucleic acids, has low similarity to human ZNF146, which binds DNA, zinc, and heparin and may be involved in development or progression of pancreatic carcinomas zinc finger protein C27A12.4 C27A12.4 Protein of unknown function, has weak similarity to C. elegans F34D10.4 C27A12.5 ceh-2;C27A12.5 Protein containing a homeobox domain (homeodomain), which are found in transcription factors, has a region of high similarity to a region of empty spiracles homolog 2 (human EMX2), which may play a role in cerebral cortex development and schizencephaly homeobox protein; ceh-2 encodes a homeodomain protein homologous to Drosophila empty spiracles (EMS) and the vertebrate EMX1 and EMX2 proteins (OMIM:600034, 600035); although the exact biological role of CEH-2 in C. elegans development and/or behavior is not yet known, expression in pharyngeal neurons and muscle, as well as vulval cells (vulB1, vulB2, and vulC) at late stages of development suggests that CEH-2 may play a role in terminal differentiation events in diverse cell types. C27A12.6 C27A12.6 Member of the TRIAD family of zinc finger proteins C27A12.7 C27A12.7 Member of the Ykr017p-like protein family C27A12.8 C27A12.8 Member of the TRIAD family of zinc finger proteins C27A12.9 C27A12.9 Protein containing a type I phosphodiesterase or nucleotide pyrophosphatase domain, has low similarity to phosphatidylinositol glycan class O (mouse Pigo), which plays a role in glycosylphosphatidylinositol (GPI) anchor biosynthesis C27A2.1 C27A2.1 Putative coiled-coil protein, has similarity to members of the S. pombe SMC (structural maintenance of chromosomes) family C27A2.2 C27A2.2 Protein with high similarity to ribosomal protein L22 (human RPL22), which binds heparin and relocalizes with viral RNA in Epstein-Barr virus infected B-lymphocytes, member of the ribosomal L22e family, which are part of the large ribosomal subunit ribosomal protein L22; rpl-22 encodes a large ribosomal subunit L22 protein; by homology, RPL-22 is predicted to function in protein biosynthesis; in C. elegans, RPL-22 activity is broadly required for embryonic and germline development, as well as normal body coloration, morphology, and postembryonic growth rates. C27A2.3 C27A2.3 Protein of unknown function C27A2.4 C27A2.4 Member of the acid phosphatase protein family acid phosphotase C27A2.5 C27A2.5 Protein of unknown function, has high similarity to uncharacterized C. elegans C04G6.7 C27A2.6 C27A2.6 Possibly involved in WNT signalling; contains putative DAX, PDZ, and DEP domains similar to D. melanogaster Dishevelled dsh-2 encodes a protein containing a DIX domain, a DEP domain, and a PDZ domain that is required for embryonic viability and functions in Wnt pathway signaling between the embryonic blastomeres P2 and EMS with respect to endoderm specification and to orient the division axis of the EMS cell; expressed from the four-cell embryo stage, and is primarily associated with membranes. C27A7.1 C27A7.1 Protein containing a type I phosphodiesterase or nucleotide pyrophosphatase domain, has low similarity to ectonucleotide pyrophosphatase-phosphodiesterase 1 (human ENPP1), which is upregulated in fibroblasts of patients with non-insulin-dependent diabetes Human plasma-cell membrane glycoprotein PC-1 like; C27A7.1 is orthologous to the human gene NPPASE (ENPP1; OMIM:173335), which when mutated leads to disease. C27A7.2 C27A7.2 Protein containing a DUF23 domain of unknown function, has high similarity to uncharacterized C. elegans T22D1.1 C27A7.3 C27A7.3 Protein containing a type I phosphodiesterase or nucleotide pyrophosphatase domain, has low similarity to human ENPP1, which is a membrane ectonucleotide pyrophosphatase-phosphodiesterase Human plasma-cell membrane glycoprotein PC-1 like C27A7.4 che-11;C27A7.4 Required for normal cilial development, dauer larva formation, and chemotaxis towards water-soluble chemicals che-11 encodes a large, unfamiliar protein with orthologs in vertebrates and arthropods (e.g., KIAA0590 and CG11838-PA) and in Chlamydomonas (IFT140), as well as distant similarity to OSM-1 and ZK520.1; che-11 is required for normal synthesis of sensory cilia (via intraflagellar transport) in sensory neurons, osmotic avoidance, and dauer formation. C27A7.5 C27A7.5 Member of the asparaginase or glutaminase family, which deaminate asparagine or glutamine, contains six ankyrin (Ank) repeats, has moderate similarity to large form lysophospholipase (rat Rn.29979), which also has asparaginase activity Asparaginase ; Ank repeat C27A7.6 C27A7.6 Member of an uncharacterized protein family C27A7.7 C27A7.7 Member of the 7-transmembrane chemoreceptor family of G protein-coupled receptors (GPCR), has low similarity to C. elegans ODR-10, which is involved in odorant response C27B7.1 spr-2;C27B7.1 Protein with strong similarity to human and D. melanogaster SET proteins, suppressor of presenilin SET protein; spr-2 encodes the C. elegans ortholog of the Drosophila and mammalian SET proteins (OMIM:600960, translocation breakpoint in human SET is associated with acute myeloid leukemia); SPR-2 is predicted to be a member of the SET protein complex that functions in chromatin remodeling, DNA repair, and transcriptional regulation; in C. elegans, SPR-2 may function to regulate the activity and/or levels of the presenilin proteins encoded by sel-12 and hop-1, as mutations in spr-2 suppress mutations in sel-12 in a hop-1-dependent manner; spr-2 is detected in the nuclei of all cells at several developmental stages, including the L3 larval stage. C27B7.2 C27B7.2 Protein of unknown function C27B7.4 C27B7.4 Protein containing a helicase conserved C-terminal domain and two SNF2 related N-terminal domains, has low similarity to a region of X-linked nuclear protein (human XNP), which may be a transcriptional regulator that functions in DNA repair DNA repair protein C27B7.5 C27B7.5 Protein containing a zinc knuckle domain, which can bind eukaryotic RNA or DNA Zinc finger, CCHC class C27B7.6 C27B7.6 Member of the protein phosphatase protein family serine/threonine protein phosphatase C27B7.7 C27B7.7 Protein containing seven fibronectin type III domains, which are involved in cell surface binding, and an immunoglobulin (Ig) domain, which may be involved in protein interactions, has weak similarity to a region of C. elegans DIG-1 fibronectin type-III repeats C27B7.8 C27B7.8;rrp-1 Protein with strong similarity to ras related protein 1b (human RAP1B), which is involved in cell cycle progression, cellular proliferation and possibly cAMP-responsive tumorigenesis, member of the Ras superfamily of GTP binding proteins ras protein; rap-1 encodes a member of the Ras superfamily of small GTPases; the activated protein interacts with W05B10.4 and T14G10.2 in yeast two-hybrid assays and rap-1 is expressed in some neurons in the head and tail, the rectal epithelial cells, body muscle, hypodermis, and in the somatic cells of the gonad. C27C12.1 C27C12.1 Protein with moderate similarity to C. elegans R107.6 gene product C27C12.2 C27C12.2 Protein containing three C2H2 type zinc finger domains, which bind nucleic acids, has a region of high similarity to a region of early growth response 1 (human EGR1), which is an early response protein induced by a wide variety of stimuli Zinc finger, C2H2 type (3 domains); C27C12.2 is orthologous to the human gene BA436D10.3 (EARLY GROWTH RESPONSE 2 (KROX-20 (DROSOPHILA) HOMOLOG)) (EGR2; OMIM:129010), which when mutated leads to disease. C27C12.3 C27C12.3 Protein of unknown function, has high similarity to uncharacterized C. elegans F31F6.1 member of worm-specific protein family C27C12.4 C27C12.4 Protein of unknown function, has low similarity to uncharacterized human ET C27C12.5 C27C12.5 Member of the amiloride-sensitive sodium channel family, which are involved in sodium reabsorption, has low similarity to a region of C. elegans FLR-1, which is a membrane protein that confers wild-type sensitivity to fluoride C27C12.6 C27C12.6 Protein containing one DM (dsx and mab-3) DNA binding domain doublesex protein like C27C12.7 C27C12.7 Member of the prolyl oligopeptidase family, contains a dipeptidyl peptidase IV N-terminal domain, has low similarity to fibroblast activation protein (mouse Fap), which is a serine protease that may be involved in cell proliferation and embryogenesis dipeptidyl aminopeptidase like C27C7.1 C27C7.1 Protein of unknown function, has high similarity to uncharacterized C. elegans H11L12.1 C27C7.2 C27C7.2 Protein with strong similarity to C. elegans ZK1025.4 gene product C27C7.3 nhr-74;C27C7.3 Member of the zinc finger protein family with similarity to nuclear hormone receptors nuclear hormone receptor C27C7.4 nhr-73;C27C7.4 Member of the zinc finger protein family with similarity to nuclear hormone receptors Zinc finger, C4 type (two domains) C27C7.5 C27C7.5 Member of the galectin family, which are lectins that bind beta galactosides, has moderate similarity to uncharacterized C. elegans T02G6.7 C27C7.7 C27C7.7 Protein of unknown function, has low similarity to uncharacterized C. elegans PES-10 C27C7.8 C27C7.8 Protein containing a nuclear hormone receptor ligand-binding domain, has high similarity to uncharacterized C. elegans ZK1025.6 C27D11.1 egl-45;C27D11.1 Putative large subunit of translation initiation factor eIF3 egl-45 encodes a homolog of eukaryotic translation initiation factor 3, subunit 10, that affects development of the HSNs that affect egg laying. C27D6.1 C27D6.1 Putative coiled-coil protein, has weak similarity to myosin heavy chains C27D6.10 srb-1;C27D6.10 G protein-coupled receptor; member of a subfamily with SRB proteins, which are expressed in chemosensory neurons; no homolog found in human or D. melanogaster 7TM chemoreceptor, srb family C27D6.3 C27D6.3 Protein of unknown function, has high similarity to uncharacterized C. elegans F11G11.4 MST101-2 protein (Fruit Fly) C27D6.4 C27D6.4 Protein containing a bZIP (basic-leucine zipper) transcription factor domain, has a region of moderate similarity to a region of cAMP responsive element binding protein 3 (human CREB3), which is a transcription factor that binds human HCFC1 BZIP protein C27D6.5 C27D6.5 Protein with strong similarity to C. elegans C34F11.7 gene product C27D6.6 srb-5;C27D6.6 G protein-coupled receptor; member of a subfamily with SRB proteins, which are expressed in chemosensory neurons; no homolog found in human or D. melanogaster 7TM chemoreceptor, srb family C27D6.7 srb-4;C27D6.7 G protein-coupled receptor; member of a subfamily with SRB proteins, which are expressed in chemosensory neurons; no homolog found in human or D. melanogaster C27D6.8 srb-3;C27D6.8 G protein-coupled receptor; member of a subfamily with SRB proteins, which are expressed in chemosensory neurons; no homolog found in human or D. melanogaster 7TM chemoreceptor, srb family C27D6.9 srb-2;C27D6.9 G protein-coupled receptor; member of a subfamily with SRB proteins, which are expressed in chemosensory neurons; no homolog found in human or D. melanogaster 7TM chemoreceptor, srb family C27D8.1 C27D8.1 Protein containing a protein kinase domain, has low similarity to casein kinase 1 epsilon (mouse Csnk1e), which is a putative serine-threonine protein kinase with broad substrate specificity that may act in DNA repair and regulation of circadian rhythm serine/threonine kinase C27D8.2 C27D8.2 Protein of unknown function C27D8.3 C27D8.3 Protein of unknown function, has moderate similarity to uncharacterized C. elegans T12G3.2 The C27D8.3 gene encodes a protein that may be involved in apoptosis. C27D8.4 C27D8.4 Protein of unknown function, has weak similarity to C. elegans C01G8.3 C27D8.5 C27D8.5 Putative ortholog of C. elegans T23B5.3 gene product C27D9.1 C27D9.1 Protein of unknown function, has low similarity to uncharacterized C. elegans F53C3.11 C27D9.2 C27D9.2 Protein of unknown function, has moderate similarity to uncharacterized C. elegans F26G1.3 C27F2.1 C27F2.1 Protein with weak similarity to C. elegans C51G7.C gene product C27F2.10 C27F2.10 Protein of unknown function C27F2.2 C27F2.2 Member of the ion transport family, which include calcium, sodium, and potassium channels, has weak similarity to voltage-dependent L-type calcium channel (rat Cacna1c), which is a pore-forming subunit of a dihydropyridine-sensitive calcium channel calcium channel subunit; nca-2 encodes a four-domain, voltage-gated ion channel; NCA-2 is required for normal rates of movement and may function with NCA-1, another voltage-gated ion channel, to regulate locomotion; NCA-2 is expressed in the nerve ring, ventral cord motorneurons, and a subset of tail neurons. C27F2.4 C27F2.4 Protein of unknown function, has high similarity to uncharacterized S. pombe Spac26a3.06p Methyltransferase C27F2.5 C27F2.5 Protein with high similarity to human EAP30, which is a subunit of the ELL transcription elongation factor complex that binds to and derepresses the RNA polymerase II inhibitory activity of ELL S. cerevisiae Snf8p C27F2.6 C27F2.6 Putative ortholog of C. elegans twk-5 gene product C27F2.7 C27F2.7 Protein of unknown function, has weak similarity to S. cerevisiae Yol072p and Yjr084p This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins. C27F2.8 C27F2.8 Protein of unknown function, has weak similarity to uncharacterized mouse Rw1 C27F2.9 C27F2.9 Protein of unknown function C27H2.1 C27H2.1 Putative transposase C27H2.2 C27H2.2 Protein of unknown function C27H2.3 C27H2.3 Protein with similarity at the N-terminus of human Hs.169638 protein, DIFF40 protein C27H5.1 C27H5.1 Protein of unknown function, has high similarity to uncharacterized cGMP phosphodiesterase delta subunit (human PDE6D) C27H5.2 C27H5.2 Protein of unknown function, has weak similarity to uncharacterized C. elegans F46H5.7 C27H5.3 C27H5.3 Member of the zinc finger in Ran binding proteins family, which may be involved in nuclear transport, contains an RNA recognition motif Probable RNA binding protein C27H5.4 C27H5.4 Protein of unknown function, has low similarity to uncharacterized C. elegans F28B3.5 C27H5.5 col-36;C27H5.5 Collagen of the COL-6 family of collagens; has strong similarity to D. melanogaster Cg25C gene product cuticular collagen; col-36 encodes a collagen protein; expressed during the L1 to L2 and L2 to dauer larval stage molts. C27H5.6 C27H5.6 Protein with moderate similarity to C. elegans R02D5.6 gene product C27H5.7 C27H5.7 Protein of unknown function C27H5.8 C27H5.8 Protein containing neurotransmitter-gated ion-channel ligand binding and transmembrane domains, has moderate similarity to C. elegans GLC-1, which is an alpha subunit of avermectin-sensitive glutamate-gated chloride channel GluCl ligand-gated ionic channel; glc-4 encodes a predicted glutamate-gated chloride channel that affects ivermectin sensitivity and reversal behavior and genetically interacts with avr-14; expressed in neurons. C27H6.1 C27H6.1 Member of the clathrin adaptor complexes medium chain family, which are involved in transport of clathrin-coated vesicles, has a region of low similarity to a region of stoned B/TFIIA alpha/beta like factor (human SALF) Adaptor complexes medium subunit family; apt-10 encodes the C. elegans ortholog of the mammalian Stonins and Drosophila Stoned B, membrane-associated proteins that contain three distinct domains: a proline-rich domain, a stonin homology domain, and a domain paralogous to the mu-adaptin subunits of adaptor protein complexes 1-3; by homology, APT-10 is predicted to regulate the activity of the heteromeric AP-1 and AP-2 clathrin adaptor protein complexes, and thus to play a role in intracellular protein trafficking and endocytosis; in vivo, apt-10 is required for the secretion of EGL-17/FGF, required for sex myoblast migration, from the vulval precursor cell P6. | apt-10 encodes the C. elegans ortholog of the mammalian Stonins and Drosophila Stoned B, membrane-associated proteins that contain three distinct domains: a proline-rich domain, a stonin homology domain, and a domain paralogous to the mu-adaptin subunits of adaptor protein complexes 1-3; by homology, APT-10 is predicted to regulate the activity of the heteromeric AP-1 and AP-2 clathrin adaptor protein complexes, and thus to play a role in intracellular protein trafficking and endocytosis; in vivo, apt-10 is required for the secretion of EGL-17/FGF, required for sex myoblast migration, from the vulval precursor cell P6.p; loss of apt-10 activity via large-scale RNAi screens, however, does not result in any obvious abnormalities. C27H6.2 C27H6.2 Member of a protein family Yeast hypothetical 50.5 KD protein like C27H6.3 C27H6.3 Protein of unknown function, has weak similarity to C. elegans F36H12.2 C27H6.4 C27H6.4 Protein of unknown function, has high similarity to uncharacterized C. elegans R13H9.1 C28A5.1 C28A5.1 Protein of unknown function, has strong similarity to uncharacterized C. elegans C28A5.2 C28A5.2 C28A5.2 Protein of unknown function, has strong similarity to uncharacterized C. elegans C28A5.1 C28A5.3 nex-3;C28A5.3 Member of the annexin family, which exhibit calcium-dependent phospholipid binding, has moderate similarity to annexin V (human ANXA5), which is a calcium-dependent phospholipid-binding protein that inhibits phospholipase A2 activity Annexin; nex-3 encodes an annexin, a member of a family of calcium-dependent phospholipid binding proteins; by homology, NEX-3 could function in a number of processes, such as membrane fusion, cytoskeletal interactions, and intracellular signaling; however, as loss of nex-3 function via RNA-mediated interference (RNAi) does not result in any abnormalities, the precise role of NEX-3 in C. elegans development and/or behavior is not yet known. C28A5.4 ceh-43;C28A5.4 Homeodomain transcription factor required for the development of the anterior hypodermis, has similarity to D. melanogaster DLL (Distal-less) and human DLX5 homeodomain transcription factors homeobox protein (distal-less subfamily); A homeobox protein of the Distal-less (Dll) class that is required for development of the anterior hypdermis during embryonic morphogenesis for cell adhesion; also affects embryonic and larval viability; it is predominantly expressed in the head hypdodermis, neuronal support cells and CAN neurons. C28A5.5 C28A5.5 Protein of unknown function C28A5.6 C28A5.6 Putative ortholog of C. elegans K09C6.1 gene product serine/threonine kinase C28C12.1 C28C12.1 Protein of unknown function C28C12.10 C28C12.10 Protein with moderate similarity over the middle region to H. sapiens FGD1 gene product [faciogenital dysplasia] C28C12.11 C28C12.11 Protein of unknown function C28C12.12 C28C12.12 Protein of unknown function C28C12.13 C28C12.13 Putative ortholog of C. elegans C33A12.14 gene product 7TM chemoreceptor, sru family C28C12.2 C28C12.2 Protein of unknown function C28C12.3 C28C12.3 Protein containing a DUF148 domain of unknown function, has high similarity to uncharacterized C. elegans T05E11.8 C28C12.4 C28C12.4 Protein containing a DUF148 domain of unknown function, has high similarity to uncharacterized C. elegans ZK596.1 C28C12.5 C28C12.5 Protein with strong similarity to C. elegans C28C12.7 gene product C28C12.6 C28C12.6 Protein with moderate similarity to C. elegans C28C12.5 gene product C28C12.7 C28C12.7 Protein with strong similarity to C. elegans C28C12.5 gene product spp-10 encodes two protein isoforms that are orthologous to the human gene PROSAPOSIN (PSAP; OMIM:176801, mutated in Gaucher disease and metachromatic leukodystrophy); SPP-10A and -10B are predicted to have 3 and 4 embedded saposin sequences, that are likely to be split into individual saposin peptides by proteolysis; in mammals, saposins activate the enzymes sphingomyelinphosphodiesterase and beta-glucosylceramidase; spp-10 has no obvious function in mass RNAi assays. C28C12.8 C28C12.8 Protein containing one helix-loop-helix DNA-binding domain, which mediate protein dimerization C28C12.9 C28C12.9 Protein with weak similarity to very-long-chain acyl-coenzyme A dehydrogenase (rat Acadvl), which is a rate-controlling enzyme in beta-oxidation of long-chain fatty acids gei-9 encodes a protein containing a putative acyl-CoA dehydrogenase domain; interacts with GEX-3 in yeast two-hybrid assays. C28D4.1 C28D4.1 Protein containing nuclear hormone receptor C4-type zinc finger and ligand-binding domains, has weak similarity to hepatic nuclear factor 4 (mouse Hnf4), which regulates liver-specific gene expression and is involved in metabolism and development Ligand-binding domain of nuclear hormone receptors, Zinc finger, C4 type C28D4.2 C28D4.2 Member of the choline or ethanolamine kinase family, which catalyze the formation of phosphatidylcholine by the CDP-choline pathway, has moderate similarity to choline-ethanolamine kinase (rat Chkl), which is involved in phosphatidylcholine biosynthesis choline kinase C28D4.3 C28D4.3 Protein with high similarity to glutamine synthase (rat Glul), which catalyzes the condensation of glutamate and ammonia to form glutamine and may clear L-glutamate from neuronal synapses, contains one glutamine synthetase domain glutamine synthase C28D4.4 C28D4.4 Protein of unknown function, has high similarity to uncharacterized C. elegans C28D4.5 C28D4.5 C28D4.5 Protein of unknown function, has high similarity to uncharacterized C. elegans C28D4.4 C28D4.7 C28D4.7 Putative ortholog of C. elegans C28D4.4 gene product C28D4.8 C28D4.8 Putative ortholog of C. elegans C28D4.4 gene product C28D4.9 C28D4.9 Putative ortholog of C. elegans C28D4.1 gene product Ligand-binding domain of nuclear hormone receptors, Zinc finger, C4 type C28F5.1 C28F5.1 Protein of unknown function C28F5.2 C28F5.2 Protein with moderate similarity to C. elegans W01C9.5 gene product C28F5.3 C28F5.3 Protein of unknown function C28F5.4 C28F5.4 Member of the insulinase (peptidase M16) family, has low similarity to insulin-degrading enzyme (insulysin, rat Ide), which degrades insulin, amyloid beta (rat App), insulin-like growth factors, amylin (rat Iapp), and natriuretic peptides insulinase; This gene encodes a protein predicted by Eisenberg and coworkers, with 68% accuracy, to be mitochondrial. C28F5.5 C28F5.5 TcA transposase transposase C28G1.1 C28G1.1 Member of the ubiquitin-conjugating enzyme (E2) family, has a region of moderate similarity to a region of huntingtin interacting protein 2 (human HIP2), which is a ubiquitin-conjugating enzyme that interacts with huntingtin (human HD) ubiquitin-conjugating enzyme; ubc-23 encodes a predicted conjugating enzyme (UBCs/E2s) of the ubiquitin-conjugation system; expressed in larvae and adults in cells around the pharynx and in intestinal cells. C28G1.2 C28G1.2 Predicted member of the serpin superfamily and a member of the Heat Shock (HS47) family of serpins according to sequence similarity heat shock 47k protein C28G1.3 C28G1.3 Protein of unknown function GTP-binding protein and M protein C28G1.4 C28G1.4 Protein containing five C2H2 type zinc finger domains, which bind nucleic acids zinc finger C28G1.5 C28G1.5 Protein with strong similarity to C. elegans ZK1240.3 gene product C28H8.1 C28H8.1 Protein of unknown function C28H8.1 is orthologous to the human gene BCL7A (OMIM:601406), which when mutated leads to high-grade B-cell non-Hodgkin lymphoma. C28H8.11 C28H8.11 Putative tryptophan 2,3-dioxygenase tryptophan 2,3-dioxygenase C28H8.12 dnc-2;C28H8.12 Predicted component of dynactin complex; dynamitin dnc-2 encodes a member of the dynamitin family that affects spindle alignment in polarized cells in early embryos, nuclear movement, spindle morphology, chromosome segregation, and pronuclear migration. C28H8.2 C28H8.2 Protein of unknown function C28H8.3 C28H8.3 Member of the DEAD or DEAH box ATP-dependent RNA helicase family and contains a helicase conserved C-terminal domain, has a region of weak similarity to a region of human SKIV2L, which is an ATP-dependent RNA helicase C28H8.4 C28H8.4 Member of an uncharacterized protein family ER lumen protein retaining receptor C28H8.5 C28H8.5 Protein of unknown function, has high similarity to uncharacterized C. elegans C15F1.1 C28H8.6 C28H8.6 Protein with high similarity to transforming growth factor beta 1 induced transcript 1 (rat Tgfb1i1), which is a steroid receptor co-activator and focal adhesion protein that inhibits heat shock protein Hsp27, contains four LIM domains LIM domains C28H8.7 C28H8.7 Protein of unknown function, has weak similarity to C. elegans F20D6.2 C28H8.8 C28H8.8 Member of the domain of unknown function DUF13 family, has low similarity to uncharacterized C. elegans C33G8.13 C28H8.9 C28H8.9 Protein containing two PHD-fingers, which may be involved in chromatin-mediated transcriptional regulation, and a C2H2 type zinc finger domain, has a region of moderate similarity to a region of zinc finger protein 220 (human ZNF220) C29A12.1 C29A12.1 Protein of unknown function C29A12.2 C29A12.2 Putative ortholog of C. elegans T10C6.9 gene product C29A12.3 C29A12.3 Contains one ATP-dependent DNA ligase domain, has moderate similarity to S. pombe Cdc17p, which is a DNA ligase required for DNA replication and repair DNA ligase I; lig-1 is orthologous to the human gene LIM HOMEOBOX PROTEIN 3 ISOFORM B (LIG1; OMIM:600577), which when mutated leads to disease. C29A12.4 C29A12.4 Protein containing 4 extracellular laminin G domains and 2 epidermal growth factor (EGF)-like domains, has a region of weak similarity to neurexin 4 (contactin associated protein 1, human CNTNAP1), which is a neuronal paranodal transmembrane receptor neurexin I like C29A12.6 C29A12.6 Protein containing a von Willebrand factor (vWF) type A domain C29E4.1 C29E4.1 Protein containing two collagen triple helix repeats, which are found in some extracellular proteins, and a nematode cuticle collagen N-terminal domain, has low similarity to C. elegans SQT-1, which is a collagen Cuticle collagen C29E4.10 C29E4.10 Protein of unknown function C29E4.10 is orthologous to the human gene GALACTOCEREBROSIDASE (GALC; OMIM:606890), which when mutated leads to disease. C29E4.11 C29E4.11 Putative ortholog of C. elegans C29E4.9 gene product C29E4.2 C29E4.2 Protein of unknown function, has weak similarity to human pathogen Entamoeba histolytica myosin heavy chain C29E4.4 C29E4.4 Protein of unknown function C29E4.7 C29E4.7 Protein containing glutathione S-transferase N-terminal and C-terminal domains, has low similarity to glutathione-S-transferase like (human GSTTLp28), which has thiol transferase and dehydroascorbate reductase activities and modulates ryanodine receptors C29E4.8 C29E4.8 Member of the adenylate kinase protein family Adenylate kinase; This gene encodes a protein predicted by Eisenberg and coworkers, with 52% accuracy, to be mitochondrial. C29E4.9 C29E4.9 Putative ortholog of C. elegans C29E4.11 gene product C29E6.1 let-653;C29E6.1 Putative mucin-like protein required for development beyond the late L1 larval stage or early L2 larval stage LET-653 mucin like protein; let-653 encodes a mucin-like protein similar to the highly glycosylated mucins secreted by the apical surface of epithelia and believed to provide a protective barrier to exposed cellular surfaces; LET-653 is required for viability, locomotion, and for maintaining the tubular epithelial structure of the excretory cell canals. C29E6.2 C29E6.2 Member of the ion transport family, which include calcium, sodium, and potassium channels, contains 16 ankyrin (Ank) repeats, has a region of low similarity to a region of ankyrin 1 (human ANK1), which is a cytoskeletal anchor protein ankyrin repeats C29E6.3 C29E6.3 Member of the protein-tyrosine phosphatase family, which are involved in control of cell growth, proliferation, differentiation and transformation, has strong similarity to uncharacterized C. elegans ZK809.1 protein tyrosine phosphatase C29E6.4 C29E6.4 Member of a protein family C29E6.5 C29E6.5 Protein containing a nuclear hormone receptor C4-type zinc finger domain, which bind DNA and may be involved in regulation of transcription, has a region of low similarity to a region of retinoic acid receptor gamma (mouse Rarg) Zinc finger, C4 type (two domains) C29E6.6 C29E6.6 Member of the transposase family, which are required for excising and inserting mobile genetic elements, has very strong similarity to uncharacterized C. elegans C31A11.2 transposase C29F3.1 C29F3.1 Protein with high similarity to human HADHA, which is a mitochondrial long-chain enoyl-CoA hydratase and 3-hydroxyacyl-CoA dehydrogenase, contains 3-hydroxyacyl-CoA dehydrogenase C-terminal and NAD binding domains long-chain enoyl-CoA hydratase C29F3.2 wrt-8;C29F3.2 Has strong similarity to C. elegans WRT-4, a protein of unknown function Hint module C29F3.3 C29F3.3 Protein of unknown function, has high similarity to uncharacterized C. elegans ZK512.7 C29F3.4 C29F3.4 Member of the C-type lectin family Lectin C-type domain C29F3.5 C29F3.5 Member of the C-type lectin family Lectin C-type domain C29F3.6 C29F3.6 Member of the rhodopsin family of G protein-coupled receptors (GPCR), has moderate similarity to uncharacterized C. elegans K07C6.9 7 transmembrane receptor (rhodopsin family) C29F3.7 C29F3.7 Protein containing a DUF141 domain of unknown function, has moderate similarity to uncharacterized C. elegans ZK1037.6 C29F4.1 C29F4.1 Protein with high similarity to C. elegans DPY-16, contains two collagen triple helix repeats, which are found in some extracellular proteins, and a nematode cuticle collagen N-terminal domain collagen C29F4.2 C29F4.2 Member of the C. elegans putative membrane protein family 8, has a region of moderate similarity to a region of bestrophin (human VMD2), which plays a role in vision and causes Bests disease, adult vitelliform macular dystrophy, and bull's eye maculopathy Putative membrane protein C29F4.3 C29F4.3 Protein of unknown function C29F5.1 C29F5.1 Protein of unknown function C29F5.2 C29F5.2 Protein of unknown function, has low similarity to uncharacterized C. elegans F36H12.14 C29F5.3 C29F5.3 Protein of unknown function C29F5.4 C29F5.4 Protein of unknown function, has weak similarity to a member of the C. elegans EGF-like domain protein family (T13C2.4) C29F5.5 C29F5.5 Protein with strong similarity to C. elegans C29F5.2 gene product C29F5.6 C29F5.6 Member of the reverse transcriptase protein family, which are RNA-dependent DNA polymerases, has strong similarity to uncharacterized C. elegans F31A9.6 Reverse transcriptase C29F5.7 C29F5.7 Member of the globin family of oxygen transporters C29F7.1 C29F7.1 Protein containing a DUF227 domain of unknown function, has high similarity to uncharacterized C. elegans C29F7.2 C29F7.2 C29F7.2 Protein containing a DUF227 domain of unknown function, has high similarity to uncharacterized C. elegans C29F7.1 C29F7.3 C29F7.3 Protein with high similarity to UMP-CMP kinase (human UMP-CMPK), which phosphorylates nucleotide and deoxynucleotide phosphates and chemotherapeutic deoxycytidine analogs, member of the adenylate kinase family uridylate kinase; This gene encodes a protein predicted by Eisenberg and coworkers, with 52% accuracy, to be mitochondrial. C29F7.4 C29F7.4 Protein containing a fork head domain, which are found in transcription factors involved in cell fate determination, has a region of high similarity to a region of forkhead box C2 (mouse Foxc2), which is a transcriptional activator fork head domain protein C29F7.5 C29F7.5 Protein containing a fork head domain, which are found in transcription factors involved in cell fate determination, has a region of high similarity to a region of forkhead box C2 (mouse Foxc2), which is a transcriptional activator fork head domain protein; fkh-4 encodes a member of the forkhead domain transcription factor family. C29F7.6 C29F7.6 Protein containing a Jumonji (jmjC) domain, has low similarity to uncharacterized C. elegans F23D12.5 C29F7.7 C29F7.7 Protein of unknown function, has weak similarity to C. elegans F23D12.3 C29F9.1 C29F9.1 Protein of unknown function, has weak similarity to C. elegans Y119D3_456.C C29F9.10 C29F9.10 Protein containing two DUF38 domains of unknown function, has low similarity to uncharacterized C. elegans ZC47.6 C29F9.11 C29F9.11 Protein containing two F-box domains, which serve as a link between a target protein and a ubiquitin-conjugating enzyme, and a DUF38 domain of unknown function, has low similarity to C. elegans FOG-2, which is required for sexual identity of germ cells C29F9.12 C29F9.12 Protein of unknown function, has weak similarity to C. elegans F22D3.5 C29F9.13 C29F9.13 Protein containing a nuclear hormone receptor ligand-binding domain C29F9.14 C29F9.14 Protein with weak similarity to C. elegans C29F9.1 gene product C29F9.2 C29F9.2;3A339 Protein of unknown function, has weak similarity to C. elegans F17B5.1 C29F9.3 C29F9.3 Protein of unknown function, has weak similarity to uncharacterized C. elegans T17A3.2 C29F9.4 C29F9.4 Protein of unknown function C29F9.5 C29F9.5 Protein containing a transcriptional adaptor putative zinc finger (TAZ) domain, which may bind transcriptional activators and repressors, has low similarity to a region of C. elegans CBP-1, which is a transcriptional activator C29F9.6 C29F9.6 Protein containing a transcriptional adaptor putative zinc finger (TAZ) domain, which may bind transcriptional activators and repressors, has a region of high similarity to a region of E1A binding protein p300 (human EP300) C29F9.7 pat-4;ilk;C29F9.7 Strongly similar to human ILK; required for embryonic development and muscle structure integrin-linked kinase; The pat-4 gene encodes a serine/threonine kinase orthologous to human integrin-linked kinase (ILK, OMIM:602366) and is required for formation of integrin-mediated muscle cell attachments during embryogenesis; PAT-4 probably functions as an adaptor molecule and localizes to dense bodies and M lines; PAT-4 forms a ternary complex with PAT-6/actopaxin and UNC-112, and requires UNC-112, UNC-52/perlecan, PAT-2/alpha integrin, and PAT-3/beta integrin for proper localization to newly forming integrin adhesion complexes. C29F9.8 C29F9.8 Putative ortholog of C. elegans C29F9.9 gene product C29F9.9 C29F9.9 Putative ortholog of C. elegans C29F9.8 gene product C29G2.1 C29G2.1 Protein with moderate similarity to C. elegans R02D3.7 gene product C29G2.2 C29G2.2 Protein of unknown function C29G2.3 C29G2.3 Protein of unknown function C29G2.4 C29G2.4 Protein containing a DUF32 domain of unknown function, has high similarity to uncharacterized C. elegans Y45G12C.5 7TM chemoreceptor, srt family C29G2.5 C29G2.5 Protein containing a nuclear hormone receptor C4-type zinc finger domain, which bind DNA and may be involved in transcription regulation, has a region of moderate similarity to a region of C. elegans NHR-80, which acts in embryogenesis and morphogenesis 7TM chemoreceptor, srt family C29G2.6 C29G2.6 Protein with moderate similarity to C. elegans F07F6.5 gene product C29H12.1 C29H12.1 Member of the class I arginyl (R) tRNA synthetase family, has low similarity to S. cerevisiae Ydr341p, which is a cytoplasmic arginine-tRNA synthetase arginyl-tRNA synthetase C29H12.2 C29H12.2 Protein of unknown function, has high similarity to uncharacterized human FLJ20555 C29H12.3 rgs-3;C29H12.3 Protein containing two regulator of G protein signaling domains, has a region of moderate similarity to a region of regulator of G protein signaling 8 (rat Rgs8), which acts as a GTPase activating protein selective for Gi-Go alpha subunits 1R20 protein (Human); rgs-3 encodes a protein with two highly similar RGS domains with highest similarity to human RGS8. C29H12.5 C29H12.5 Protein containing a Chromo domain, which bind chromatin C29H12.6 C29H12.6 Protein of unknown function C30A5.1 C02F5.7;C30A5.1 Protein with high similarity to F box leucine rich repeat 3 (human FBXL2), which is a putative subunit of the SCF ubiquitin ligase involved in protein degradation, contains a leucine rich repeat and two F-box domains C30A5.10 C30A5.10 Protein of unknown function, putative paralog of C. elegans C30A5.6 C30A5.2 C30A5.2 Protein of unknown function, has weak similarity to human RAD51L3, a putative homolog of S. cerevisiae Rad51p rfs-1 encodes a RAD51-like protein, orthologous to mammalian RAD-51C, that is related to bacterial recA, a multifunctional enzyme involved in DNA repair, homologous recombination, and induction of the SOS response; RFS-1 has no obvious function in mass RNAi assays; however, RFS-1 can interact with RAD-51, a C. elegans RAD51 homolog involved in meiosis and DNA repair, suggesting that RFS-1 may also play a role in these processes. C30A5.3 C30A5.3 Protein of unknown function, has high similarity to uncharacterized mouse Prei3 C30A5.4 C30A5.4 Member of the protein phosphatase protein family C30A5.5 C30A5.5 Member of the synaptobrevin family, which are intrinsic membrane proteins found in small synaptic vesicles, has strong similarity to uncharacterized C. elegans T14D7.3 snb-5 encodes a predicted synaptobrevin. C30A5.6 C30A5.6 Protein of unknown function C30A5.7 unc-86;C30A5.7 POU domain homeodomain transcription factor required for the production and differentiation of assorted neurons, has similarity over 160 amino acids to D. melanogaster VVL (ventral veins lacking) homeodomain transcription factor Pou homeodomain; unc-86 encodes a transcription factor with a POU-type homeodomain that is required for correct fate determination and differentiaion in diverse neuronal lineages, including those of egg-laying neurons, mechanosensory neurons, and chemosensory interneurons; UNC-86 is orthologous to human BRN-3; UNC-86 is required for tph-1 and cat-1 expression in specific serotonergic neurons, as well as for neurite outgrowth. C30A5.9 C30A5.9 Protein with strong similarity to C. elegans Y61A9LA.N gene product transposase C30B5.1 C30B5.1 Protein with moderate similarity to C. elegans ZK154.5 gene product C30B5.2 C30B5.2 Protein of unknown function C30B5.3 cpb-2;C30B5.3 Protein with low similarity to C. elegans CPB-1, which is involved in spermatogenesis and male meiosis C. elegans protein C40H1.1; The cbp-2 gene encodes a cytoplasmic polyadenylation element binding (CPEB) protein homolog, expressed specifically in the spermatogenic germ line. C30B5.4 C30B5.4 Protein containing an RNA recognition motif (RRM, RBD, or RNP), has a region of high similarity to S. cerevisiae Ist3p, which is involved in splicing, spliceosome assembly, and possibly sodium tolerance Probable RNA binding protein C30B5.5 C30B5.5 Protein with moderate similarity to C. elegans F57A8.4 gene product C30B5.6 C30B5.6 Protein of unknown function C30B5.7 C30B5.7 Protein with strong similarity to C. elegans F09C12.6 gene product C30C11.1 C30C11.1 Protein of unknown function C30C11.2 rpn-3;C30C11.2 Protein containing a PCI (proteasome, COP9-complex and eIF3 ) or PINT (Proteasome, Int-6, Nip-1 and TRIP-15) domain, which are found in multi-protein complexes, has low similarity to S. cerevisiae Rpn33p, which is a component of the 26S proteasome complex Diphenol oxidase A2 C30C11.4 C30C11.4 Member of the Hsp70 family, which are stress-induced protein chaperones, has moderate similarity to 105 kDa heat shock protein (human HSP105B), which has expression induced by heat shock and increased in cancer cells Msi3p C30D11.1 unc-103;nerg;C30D11.1 Putative eag-like potassium channel potassium channel protein; unc-103 encodes an ERG-like K+ channel homolog, orthologous to human KCNH6 (OMIM:608168); UNC-103 regulates muscle activation in motility, egg-laying and male spicule protraction; UNC-103 is expressed highly in many neurons; gain-of-function alleles can be uncoordinated, while loss-of-function alleles have a more subtle defect in copulatory spicule protraction. C30D11.2 C30D11.2 Protein of unknown function C30E1.2 C30E1.2 Protein of unknown function, has high similarity to uncharacterized C. elegans C08A9.3 C30E1.3 C30E1.3 Protein of unknown function, has high similarity to uncharacterized C. elegans C08A9.4 C30E1.4 C30E1.4 Protein of unknown function, has moderate similarity to uncharacterized C. elegans C08A9.5 C30E1.5 C30E1.5 Protein with moderate similarity to C. elegans F30B5.5 gene product C30E1.6 C30E1.6 Protein of unknown function, has moderate similarity to uncharacterized C. elegans C08A9.3 C30E1.7 C30E1.7 Protein with strong similarity to C. elegans Y37H2C.1 gene product C30E1.8 C30E1.8 Protein of unknown function, has moderate similarity to uncharacterized C. elegans F11D11.3 C30F12.1 C30F12.1 Protein of unknown function C30F12.2 C30F12.2 Putative ortholog of S. cerevisiae Afg1p, a protein of unknown function C30F12.3 C30F12.3 Protein of unknown function C30F12.4 C30F12.4 Protein of unknown function C30F12.5 C30F12.5 Protein of unknown function C30F12.6 C30F12.6 Member of the rhodopsin family of G protein-coupled receptors (GPCR), has moderate similarity to thyrotropin-releasing hormone receptor (human TRHR), which mediates the release of thyroid stimulating hormone and prolactin (human PRL) seven trans-membrane receptor C30F12.7 C30F12.7 Protein with high similarity to C. elegans F35G12.2, which is involved in gametogenesis, larval development, and embryogenesis or morphogenesis, member of the isocitrate and isopropylmalate dehydrogenase family isocitrate dehydrogenase C30F2.1 C30F2.1 Protein containing two collagen triple helix repeats, which are found in some extracellular proteins, and a nematode cuticle collagen N-terminal domain, has a region of moderate similarity to a region of C. elegans BLI-1 collagen C30F2.2 C30F2.2 Protein of unknown function, has weak similarity to C. elegans C53A5.6 Zinc finger, C3HC4 type (RING finger) C30F2.3 C30F2.3 Protein of unknown function C30F8.2 C30F8.2 Protein of unknown function vaculolar ATPase C30F8.3 C30F8.3 Protein of unknown function C30F8.4 C30F8.4 Protein with strong similarity to C. elegans abl-1 gene product protein kinase; kin-32 encodes an ortholog of human focal adhesion kinase (FAK1; Q05397; OMIM:600758), also known as cytoplasmic protein-tyrosine kinase (PTK2). C30G12.1 C30G12.1 Protein of unknown function, has weak similarity to C. elegans R01E6.2 C30G12.2 C30G12.2 Member of the short-chain dehydrogenase-reductase family, which are NAD- or NADP-dependent oxidoreductases, has low similarity to rat Cbr, which is a broad-specificity NADPH-dependent oxidoreductase Alcohol dehydrogenase C30G12.3 C30G12.3 Protein of unknown function C30G12.4 C30G12.4 Protein containing one DUF225 domain of unknown function C30G12.5 C30G12.5 Protein of unknown function C30G12.6 C30G12.6 Protein of unknown function C30G12.7 puf-8;C30G12.7 Protein containing eight Pumilio-family (Puf) RNA binding domains, has moderate similarity to a region of S. cerevisiae Puf3p, which is involved in metabolism of S. cerevisiae COX17 mRNA C30G4.1 C30G4.1 Member of the transposase family, which are required for excising and inserting mobile genetic elements, has very strong similarity to uncharacterized C. elegans F27B3.4 transposase C30G4.2 C30G4.2 Protein of unknown function C30G4.3 gcy-11;C30G4.3 Putative guanylyl cyclase guanylate cyclase receptor C30G4.4 C30G4.4 Protein of unknown function C30G4.5 C30G4.5 Protein of unknown function C30G4.6 C30G4.6 Protein containing a DUF41 domain of unknown function C30G4.7 C30G4.7 Protein with weak similarity to C. elegans Y48C3A.12 gene product C30G7.1 C30G7.1 Member of the histone H1 and H5 family of linker histones, has low similarity to the 21.5 kDa form of histone H1 (C. elegans HIS-24), which plays a role in gonad and germ cell development and in chromatin silencing histone H1 like C30H6.1 C30H6.1 Protein with strong similarity to C. elegans C49C3.13, a member of the C-type lectin family Lectin C-type domain short and long forms C30H6.2 C30H6.2 Member of the ZIP zinc transporter family, which may be metal transporters tag-141/C30H6.2 encodes a putative zinc transporter orthologous to human SLC39A4 (OMIM:607059, mutated in acrodermatitis enteropathica). C30H6.3 C30H6.3 Protein containing a C-type lectin domain, which mediate calcium-dependent carbohydrate recognition C30H6.4 C30H6.4 Member of the C-type lectin family, has similarity to human fibroblast chondroitin sulfate proteoglycan core protein, which has lectin-like properties Lectin C-type domain short and long forms C30H6.5 C30H6.5 Protein of unknown function C30H6.6 C30H6.6 Member of the ABC transporter family, which are involved in translocation across biological membranes, contains an ABC transporter transmembrane domain, has moderate similarity to S. cerevisiae Mdl1p, which is involved in mitochondrial peptide release multidrug resistance protein (p-glycoprotein); haf-1 encodes a predicted transmembrane protein of the ATP-binding cassette (ABC) transporter superfamily; by homology, HAF-1 is proposed to function in ATP-dependent transport of molecules across plasma and intracellular membranes; however, as loss of HAF-1 function via RNA-mediated interference (RNAi) does not result in any abnormalities, the precise role of HAF-1 in C. elegans development and/or behavior is not yet known. C30H6.7 C30H6.7 Protein containing a 2-oxo acid dehydrogenases acyltransferase catalytic domain and an E3 binding domain, has moderate similarity to a region of dihydrolipoamide dehydrogenase-binding protein (protein X, human PDX1) 2-oxo acid dehydrogenases acyltransferase (catalytic domain); This gene encodes a protein predicted by Eisenberg and coworkers, with 68% accuracy, to be mitochondrial. C30H6.8 C30H6.8 Member of the thioredoxin family, has moderate similarity to C. elegans R05H5.3, which is involved in embryogenesis or morphogenesis Thioredoxins C30H6.9 C30H6.9 Protein of unknown function C30H7.2 C30H7.2 Member of the thioredoxin family, has low similarity to glucose regulated 58kDa protein human (GRP58), which acts as a protein disulfide isomerase involved in folding and maturation of N-linked glycoproteins and MHC class I antigen processing C31A11.1 C31A11.1 Member of the uncharacterized protein family UPF0063, has high similarity to uncharacterized C. elegans C31A11.5 C31A11.2 C31A11.2 Member of the transposase family, which are required for excising and inserting mobile genetic elements, has very strong similarity to uncharacterized C. elegans F47G9.5 Transposase C31A11.3 C31A11.3 Protein containing two DUF40 domains of unknown function, which contain four conserved cysteines, has low similarity to uncharacterized C. elegans C02A12.5 7TM receptor, srbc family C31A11.4 C31A11.4 Protein containing a DUF40 domain of unknown function, which contain four conserved cysteines, has high similarity to uncharacterized C. elegans M01B2.3 7TM receptor, srbc family C31A11.5 C31A11.5 Member of the uncharacterized protein family UPF0063, has high similarity to uncharacterized C. elegans C31A11.1 C31A11.6 C31A11.6 Protein of unknown function, has high similarity to uncharacterized C. elegans W07A8.5 C31A11.7 C31A11.7 Member of the uncharacterized protein family UPF0063, has high similarity to uncharacterized C. elegans C31A11.5 C31A11.8 C31A11.8 TcA transposase Tc1 transposase C31A11.9 C31A11.9 Member of the 7-transmembrane chemoreceptor family of G protein-coupled receptors (GPCR), has low similarity to C. elegans ODR-10, which is involved in odorant response C31B8.1 C31B8.1 Protein with moderate similarity to C. elegans F59B1.6 gene product C31B8.11 C31B8.11 Protein of unknown function, has strong similarity to uncharacterized C. elegans SRH-37 7TM chemoreceptor, srh family C31B8.12 C31B8.12 Member of the domain of unknown function DUF13 family, has high similarity to uncharacterized C. elegans Y82E9BL.12 C31B8.13 C31B8.13 Member of the 7-transmembrane chemoreceptor family of G protein-coupled receptors (GPCR), has high similarity to uncharacterized C. elegans H05B21.2 7TM chemoreceptor, srh family C31B8.2 C31B8.2 Protein with moderate similarity to C. elegans F47G4.1 gene product C31B8.4 C31B8.4 Protein of unknown function, has weak similarity to uncharacterized C. elegans C17H1.3 C31B8.6 C31B8.6 Member of the 7-transmembrane chemoreceptor family of G protein-coupled receptors (GPCR), has low similarity to C. elegans ODR-10, which is involved in odorant response 7TM chemoreceptor, str family C31B8.7 C31B8.7 Protein containing a DUF138 domain of unknown function, has high similarity to uncharacterized C. elegans T06A1.5 C31B8.8 C31B8.8 Putative matrix metalloprotease C31B8.9 C31B8.9 Protein of unknown function, has high similarity to uncharacterized C. elegans K06H6.5 C31C9.1 C31C9.1 Protein of unknown function apical gut membrane protein C31C9.2 C31C9.2 Protein containing a D-isomer specific 2-hydroxyacid dehydrogenase catalytic domain and a D-isomer specific 2-hydroxyacid dehydrogenase NAD binding domain, has low similarity to human GRHPR, which is a glyoxylate reductase-hydroxypyruvate reductase D-3-Phosphoglycerate dehydrogenase; C31C9.2 is orthologous to the human gene PHOSPHOGLYCERATE DEHYDROGENASE (PHGDH; OMIM:606879), which when mutated leads to phosphoglycerate dehydrogenase deficiency. C31C9.3 C31C9.3 Protein containing a DUF38 domain of unknown function and an F-box domain, which serve as a link between a target protein and a ubiquitin-conjugating enzyme, has low similarity to C. elegans T07D3.1, which may act in germ-line stem cell differentiation This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins; this gene's encoded protein also contains an FTH/DUF38 motif, which may also mediate protein-protein interaction. C31C9.4 C31C9.4 Protein containing two DUF38 domains of unknown function and two F-box domains, which serve as a link between a target protein and a ubiquitin-conjugating enzyme This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins; this gene's encoded protein also contains an FTH/DUF38 motif, which may also mediate protein-protein interaction. C31C9.5 C31C9.5 Member of the reverse transcriptase protein family, which are RNA-dependent DNA polymerases, has high similarity to uncharacterized C. elegans ZK1320.8 reverse transcriptase; This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins. C31E10.1 C31E10.1 Member of the 7-transmembrane chemoreceptor family of G protein-coupled receptors (GPCR), has moderate similarity to uncharacterized C. elegans R08C7.7 C31E10.2 C31E10.2 Putative ortholog of C. elegans K02A2.6 gene product reverse transcriptase C31E10.3 C31E10.3 Protein containing a DUF41 domain of unknown function, has low similarity to uncharacterized C. elegans Y46H3D.4 C31E10.4 C31E10.4 Protein of unknown function, has weak similarity to C. elegans Y18D10A.R C31E10.5 C31E10.5 Protein of unknown function, has weak similarity to uncharacterized C. elegans C16A11.2 C31E10.6 C31E10.6 Protein of unknown function, has weak similarity to uncharacterized C. elegans C16A11.2 C31E10.7 C31E10.7 Protein containing a heme-binding domain, has moderate similarity to cytochrome b5 (S. cerevisiae Cyb5p), which is likely to play a role in sterol metabolism cytochrome b5; C31E10.7 is orthologous to the human gene UNKNOWN (PROTEIN FOR MGC:10230) (CYB5; OMIM:250790), which when mutated leads to disease. C31E10.8 C31E10.8 Protein containing a TBC domain, which may be GTPase activators of Rab-like small GTPases, has a region of low similarity to a region of mouse Vrp S.pombe protein C4G8.04 like C31G12.1 C31G12.1 Protein of unknown function, has strong similarity to uncharacterized C. elegans W04E12.2 C31G12.2 C31G12.2 Member of the C-type lectin family Lectin C-type domain short and long forms C31G12.3 C31G12.3 Protein of unknown function C31G12.4 C31G12.4 Protein containing an F-box domain, which serve as a link between a target protein and a ubiquitin-conjugating enzyme C31H1.1 C31H1.1 Protein of unknown function, has moderate similarity to uncharacterized C. elegans T25B9.6 C31H1.2 C31H1.2 Protein of unknown function C31H1.3 C31H1.3 Putative ortholog of C. elegans F14F9.6 gene product C31H1.5 C31H1.5 Protein with moderate similarity to C. elegans F35C11.5 gene product C31H1.6 C31H1.6 Protein of unknown function, has low similarity to uncharacterized C. elegans B0001.1 C31H1.7 C31H1.7 Protein of unknown function C31H1.8 C31H1.8 Protein of unknown function C31H2.1 C31H2.1 Protein containing a TBC domain, which may be GTPase activators of Rab-like small GTPases C31H2.2 C31H2.2 Protein containing a collagen triple helix repeats, which are found in some extracellular proteins, and a nematode cuticle collagen N-terminal domain, has a region of moderate similarity to C. elegans DPY-7, which is a cuticle collagen collagen alpha (weak); dpy-8 encodes a collagen with a nematode-specific N-terminal domain that is required for normal body morphology and (perhaps) for a normal embryonic cell division rate; dpy-8 interacts genetically with emb-5 and glp-1. C31H2.3 C31H2.3 Protein of unknown function 4-hydroxyphenylpyruvate dioxygenase (4HPPD) C31H2.4 C31H2.4 Protein with moderate similarity to 4-hydroxyphenylpyruvate dioxygenase (rat Hpd), which is an enzyme of tyrosine catabolism C31H2.4 is orthologous to human 4-HYDROXYPHENYLPYRUVATE DIOXYGENASE (HPD; OMIM:276710), which when mutated leads to tyrosinemia type III; C31H2.4 is somewhat less similar to human HPD than C. elegans HPD-1 (to which C31H2.4 is paralogous). C31H5.1 C31H5.1 Protein of unknown function, has high similarity to uncharacterized C. elegans F35H12.5 C31H5.3 acr-19;C31H5.3 Protein containing neurotransmitter-gated ion-channel ligand binding and transmembrane domains, has moderate similarity to alpha 7 subunit of the neuronal nicotinic acetylcholine receptor (rat Chrna7), which plays a role in neurotransmission nicotinic acetylcholine receptor; acr-19 encodes a predicted member of the alpha subunit family of nicotinic acetylcholine receptors. C31H5.4 C31H5.4 Protein of unknown function C31H5.5 C31H5.5 Protein of unknown function C31H5.6 C31H5.6 Putative acyl-CoA thioesterase C32A3.1 sel-8;lag-3;C32A3.1 Glutamine rich protein that is a probably a transcription factor required for the normal function of the C. elegans glp-1 and lin-12 signaling pathways sel-8 encodes a nuclear protein required for LIN-12 and GLP-1 signalling; SEL-8 contains a novel motif shared with W09C5.1 and orthologs of W09C5.1 in S. cerevisiae (YER126c), Drosophila (DMIP259), and also has two prominent glutamine-rich domains. C32A3.2 C32A3.2 Protein of unknown function C32A3.3 C32A3.3 Protein with coiled coil domains, has similarity to D. melanogaster EG:132E8.4 protein coiled coil domains C32A9.1 C32A9.1 Protein of unknown function C32B5.1 C32B5.1 Putative ortholog of C. elegans F45D11_39.B gene product C32B5.10 C32B5.10 Protein containing an F-box domain, which serve as a link between a target protein and a ubiquitin-conjugating enzyme, has high similarity to uncharacterized C. elegans R07C3.8 C32B5.11 C32B5.11 Protein with moderate similarity to C. elegans C32B5.12 gene product C32B5.12 C32B5.12 Protein of unknown function, has low similarity to uncharacterized C. elegans F58H7.8 C32B5.13 C32B5.13 Member of the papain family of cysteine proteases, has low similarity to a region of cathepsin H (rat Ctsh), which is a cysteine (thiol) protease that is involved in a variety of proteolytic processes and is inhibited by stefins A and B C32B5.14 C32B5.14 Protein of unknown function, has low similarity to uncharacterized C. elegans C32B5.16 C32B5.15 C32B5.15 Protein containing an F-box domain, which serve as a link between a target protein and a ubiquitin-conjugating enzyme, has low similarity to uncharacterized C. elegans C39B5.2 This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins. C32B5.16 C32B5.16 Protein of unknown function, has low similarity to uncharacterized C. elegans C32B5.14 C32B5.2 C32B5.2 Member of the 7-transmembrane chemoreceptor family of G protein-coupled receptors (GPCR), has high similarity to uncharacterized C. elegans C03G6.7 7TM chemoreceptor, srh family C32B5.3 C32B5.3 Protein with strong similarity to C. elegans C32B5.16 gene product C32B5.4 C32B5.4 Protein of unknown function, has moderate similarity to uncharacterized C. elegans C32B5.16 C32B5.5 C32B5.5 Protein of unknown function, has low similarity to uncharacterized C. elegans C32B5.16 C32B5.6 C32B5.6 Protein of unknown function C32B5.7 C32B5.7 Member of the papain family of cysteine proteases, has moderate similarity to a region of cathepsin H (rat Ctsh), which is a cysteine (thiol) protease involved in a variety of proteolytic processes and is inhibited by stefins A and B cathepsin-like peptidase C32B5.8 C32B5.8 Protein of unknown function, has low similarity to uncharacterized C. elegans C32B5.16 C32B5.9 C32B5.9 Protein of unknown function, has low similarity to uncharacterized C. elegans C44C8.3 C32C4.1 nShab4;C32C4.1 Putative voltage-gated potassium channel potassium channel; This gene encodes a protein predicted by Eisenberg and coworkers, with 52% accuracy, to be mitochondrial. C32C4.2 C32C4.2 Protein with high similarity to C. elegans AQP-CE2, which is a mercury-sensitive water channel protein, member of the major intrinsic protein (MIP) family, which are transmembrane channels MIP protein C32C4.3 C32C4.3 Protein of unknown function C32D5.1 C32D5.1 Protein of unknown function, has weak similarity to C. elegans Y55F3A_747.J C32D5.10 C32D5.10 Protein containing a C3HC4 type (RING) zinc finger, which may mediate protein-protein interactions C32D5.11 C32D5.11 Protein containing a C3HC4 type (RING) zinc finger, which may mediate protein-protein interactions C32D5.12 C32D5.12 Protein containing an NAD-dependent epimerase/dehydratase domain and a 3-beta hydroxysteroid dehydrogenase/isomerase domain, has weak similarity to S. cerevisiae C-3 sterol dehydrogenase (Ygl001p) C32D5.2 sma-6;C32D5.2 Receptor serine/threonine protein kinase with similarity to human TGF-beta receptor and bone morphogenetic protein receptor, involved in body size regulation and male tail development Activin receptor C32D5.3 C32D5.3 Putative ortholog of human Hs.84087 gene product, protein KIAA0143 isolated from human cell line KG-1 cDNA library C32D5.4 C32D5.4 Protein of unknown function C32D5.5 C32D5.5 Protein of unknown function, has moderate similarity to uncharacterized human CGI-85 C32D5.6 C32D5.6 Protein containing a TPR (tetratrico peptide repeat) domain, which may mediateprotein-protein interactions, has moderate similarity to uncharacterized human DEME-6 C32D5.7 C32D5.7 Protein of unknown function C32D5.8 C32D5.8 Protein with high similarity to C. elegans RO5H5.3, which is involved in embryogenesis or morphogenesis, member of the thioredoxin family, which are small enzymes involved in redox reactions Thioredoxin C32D5.9 C32D5.9 Protein with high similarity to S. cerevisiae Aut7p, which is required for delivery of autophagic vesicles to the vacuole and for Cvt vesicle formation, member of the microtubule associated protein 1A or 1B light chain 3 family C32E12.1 C32E12.1 Putative coiled-coil protein, has weak similarity over the N-terminus to S. cerevisiae mRNA cap-binding protein Tif4632p C32E12.2 C32E12.2 Member of the 3',5'-cyclic nucleotide phosphodiesterase family, has moderate similarity to phosphodiesterase 11A (human PDE11A), which is a dual-substrate phosphodiesterase that hydrolyzes both cGMP and cAMP cyclic nucleotide phosphodiesterase C32E12.3 C32E12.3 Protein containing a high mobility group box (HMG1 or 2) family domain, has a region of high similarity to a region of SRY box 11 (human SOX11), which is a transcriptional activator that may serve in neural differentiation and retrotransposon regulation C32E12.4 C32E12.4 Protein with weak similarity to C. elegans nmy-2, which is a nonmuscle myosin II heavy chain-related protein required for cytokinesis and establishment of early embryonic polarity C32E8.1 C32E8.1 Protein containing a C3HC4 type (RING) zinc finger, which may mediate protein-protein interactions, has a region of moderate similarity to a region of ADP-ribosylation factor domain protein 1 (rat Arfd1), which is a GTPase C32E8.10 C32E8.10 Putative ortholog of C. elegans C32E8.10A gene product unc-11 encodes multiple isoforms of a clathrin-adaptor protein AP180 (OMIM:603025) that functions in clathrin-mediated endocytosis; UNC-11 is essential for embryogenesis, locomotion, and pharyngeal pumping, and regulates neurotransmitter release by controlling vesicle trafficking and fusion; UNC-11 is also required for localization of SNB-1/synaptobrevin to synaptic vesicles, thus acting as a sorting protein as well as a clathrin-adaptor protein; UNC-11 is expressed at high levels in nearly all neurons, where it is enriched at presynaptic terminals, and is also expressed in coelomocytes, the uv1 secretory cells of the vulva, and the intestine. C32E8.11 C32E8.11 Protein containing a putative zinc finger in N-recognin domain, has a region of weak similarity to a region of ubiquitin-protein ligase (N-recognin or E3 enzyme, S. cerevisiae Ubr1p), which is involved in selection of substrates for the N-end rule pathway C32E8.2 C32E8.2 Protein with high similarity to ribosomal protein L13 (S. cerevisiae Rpl13bp), which is a structural ribosomal protein, member of the ribosomal L13e family, which are part of the large ribosomal subunit ribosomal protein L13; rpl-13 encodes a large ribosomal subunit L13 protein. C32E8.3 C32E8.3 Protein of unknown function, has moderate similarity to uncharacterized human LOC51673 C32E8.4 C32E8.4 Protein with moderate similarity to C. elegans F13E9.8 gene product C32E8.5 C32E8.5 Protein containing a forkhead associated (FHA) domain, which bind phosphopeptides, has high similarity to uncharacterized human FLJ12553 C32E8.6 C32E8.6 Member of the AMP-binding enzyme family, has low similarity to uncharacterized C. elegans C50H11.1 This gene encodes a protein predicted by Eisenberg and coworkers, with 52% accuracy, to be mitochondrial. C32E8.7 ric-19;C32E8.7 Protein with similarity to H. sapiens islet cell autoantigen 1 ), a common target of diabetic autoimmunity in humans and diabetes-prone rodents The ric-19 gene encodes an evolutionarily conserved cytosolic protein involved in neuroendocrine secretion via association with secretory vesicles. C32E8.8 ptr-2;C32E8.8 Member of the patched family, which are transmembrane receptors, has weak similarity to Niemann-Pick disease type C1 (human NPC1), which is a lysosomal protein that plays a role cholesterol transport C32E8.9 C32E8.9 Member of the enoyl-CoA hydratase or isomerase family, has low similarity to a region of short chain enoyl-Coenzyme A hydratase 1 (rat Echs1), which catalyzes the hydration of trans-2-enoyl-CoA forming 3-hydroxyacyl-CoA in fatty acid beta-oxidation C32F10.1 C32F10.1 Member of the oxysterol-binding protein (OSBP) family, which are involved in sterol biosynthesis, contains a pleckstrin homology (PH) domain, which mediate protein-protein and protein-lipid interactions, has region of low similarity to S. cerevisiae Osh7p oxysterol-binding protein C32F10.2 lin-35;C32F10.2 Similar to the Rb tumor suppressor; negative regulator of the cell cycle, and part of the class B pathway that antagonizes vulval induction lin-35 encodes the C. elegans retinoblastoma protein (Rb) ortholog; lin-35 was first identified in screens for synthetic multivulva (synMuv) genes and as a class B synMuv gene, functions redundantly with class A genes to antagonize Ras signaling and negatively regulate vulval development; in addition, LIN-35 activity is required redundantly with PHA-1 and UBC-18 for early steps in pharyngeal morphogenesis, with FZR-1 for normal postembryonic development, and with XNP-1 for somatic gonad development; on its own, LIN-35 is also required for wild-type fertility; LIN-35 is expressed broadly in embryos and L1 larvae, and is then detected in vulval precursor cells and their descendants as well as a subset of head and tail cells in later larvae and adults. C32F10.4 C32F10.4 Protein of unknown function C32F10.5 C32F10.5 Member of the DNA replication related (tentative) protein family single-strand recognition protein C32F10.6 nhr-2;crf-2;C32F10.6 Putative nuclear hormone receptor required for embryogenesis nuclear homone receptor; nhr-2 encodes a member of the nuclear hormone receptor family that is required for embryonic viability and morphogenesis; expressed during embryogenesis. C32F10.7 C32F10.7 Protein of unknown function C32F10.8 C32F10.8 Protein with high similarity to glutamic-pyruvate transaminase (alanine aminotransferase 1, human GPT), which catalyzes the conversion of alanine to pyruvate and alpha-ketoglutarate to glutamate in gluconeogenesis and amino acid metabolism alanine aminotransferase C32H11.1 C32H11.1 Protein containing a DUF141 domain of unknown function, has high similarity to uncharacterized C. elegans K08D8.4 C32H11.10 C32H11.10 Protein containing a DUF141 domain of unknown function, has very strong similarity to uncharacterized C. elegans C32H11.9 C32H11.11 C32H11.11 Protein containing a DUF148 domain of unknown function, has strong similarity to uncharacterized C. elegans C32H11.6 C32H11.12 C32H11.12 Protein containing a DUF141 domain of unknown function, has high similarity to uncharacterized C. elegans C32H11.9 C32H11.13 C32H11.13 Protein containing a DUF141 domain of unknown function, has high similarity to uncharacterized C. elegans F55G11.4 C32H11.2 C32H11.2 Protein containing a DUF216 domain of unknown function, has low similarity to uncharacterized C. elegans F58E2.9 C32H11.3 C32H11.3 Protein containing a DUF141 domain of unknown function, has high similarity to uncharacterized C. elegans C32H11.4 C32H11.4 C32H11.4 Protein containing a DUF141 domain of unknown function, has high similarity to uncharacterized C. elegans C32H11.3 C32H11.5 C32H11.5 Protein containing a DUF148 domain of unknown function, has high similarity to uncharacterized C. elegans C32H11.6 C32H11.6 C32H11.6 Protein containing a DUF148 domain of unknown function, has strong similarity to uncharacterized C. elegans C32H11.11 C32H11.7 C32H11.7 Protein with strong similarity to C. elegans Y38F2AL.6 gene product C32H11.8 C32H11.8 Protein containing a DUF148 domain of unknown function, has very strong similarity to uncharacterized C. elegans C32H11.11 C32H11.9 C32H11.9 Protein containing a DUF141 domain of unknown function, has very strong similarity to uncharacterized C. elegans C32H11.10 C33A11.1 C33A11.1 Protein with four ankyrin repeats, which may mediate protein interactions, has a region of low similarity to human NFKBIA, which is involved in transcription regulation and is associated with Hodgkin lymphoma upon gene mutation Ank repeat C33A11.2 C33A11.2 Protein of unknown function C33A11.4 C33A11.4 Protein containing a sterile alpha motif (SAM) or pointed domain, which are a subgroup of the SAM domains found in nuclear and signalling proteins, and an ETS domain, has a region of high similarity to a region of ETS homologous factor (human EHF) Ets-domain C33A12.1 C33A12.1 Protein of unknown function, has high similarity to NADH-ubiquinone oxidoreductase subunit CI-B13 (human NDUFA5), which is a subunit of the NADH-ubiquinone oxidoreductase (complex I) multiprotein complex that transports during oxidative phosphorylation NADH-ubiquinone oxidoreductase 13 KD-B subunit C33A12.10 C33A12.10 Protein containing a DUF215 domain of unknown function, has high similarity to uncharacterized C. elegans C33A12.11 7TM receptor C33A12.11 C33A12.11 Protein containing a DUF215 domain of unknown function, has high similarity to uncharacterized C. elegans C33A12.10 7TM receptor C33A12.12 C33A12.12 Protein with weak similarity to C. elegans ZYG-11, which is required for zygote formation Leucine Rich Repeat (2 copies) (2 domains) C33A12.13 C33A12.13 Protein containing a DUF215 domain of unknown function, has high similarity to uncharacterized C. elegans C33A12.14 C33A12.14 C33A12.14 Protein containing a DUF215 domain of unknown function, has high similarity to uncharacterized C. elegans C33A12.13 C33A12.15 C33A12.15 Member of the transthyretin-like family Transthyretin-like family C33A12.16 C33A12.16 Protein of unknown function, has low similarity to uncharacterized C. elegans Y77E11A.8 C33A12.2 C33A12.2 Protein of unknown function C33A12.3 C33A12.3 Protein of unknown function C33A12.4 C33A12.4 Protein of unknown function C33A12.5 C33A12.5 Member of the transposase family, which are required for excising and inserting mobile genetic elements, has very strong similarity to uncharacterized C. elegans F44F4.8 transposase C33A12.6 C33A12.6 Protein containing a UDP-glucoronosyl and UDP-glucosyl transferase domain, which transfer glycosyl groups to small hydrophobic molecules, has low similarity to olfactory UDP-glucuronosyltransferase (human UGT2A1), which catalyzes glucuronidation UDP-glucuronysltransferase C33A12.7 C33A12.7 Member of the metallo-beta-lactamase family, has high similarity to uncharacterized human YF13H12 C33A12.8 C33A12.8 Protein containing a DUF215 domain of unknown function, has high similarity to uncharacterized C. elegans C33A12.10 7TM receptor C33B4.1 clc-2;clh-2;B0491.8;C33B4.1 Chloride channel protein C33B4.2 C33B4.2 Protein of unknown function, has high similarity to uncharacterized C. elegans T23F6.2 C33B4.3 C33B4.3 Protein containing six ankyrin (Ank) repeats and a SAM (sterile alpha motif) domain, which may mediate protein-protein interactions, and a PDZ, DHR, or GLGF domain, has low similarity to a region of proline-rich synapse-associated protein 2 (rat Shank3) ankyrin and proline rich domains C33C12.1 C33C12.1 Protein of unknown function C33C12.2 C33C12.2 Protein of unknown function C33C12.3 C33C12.3 Member of the glycosyl hydrolase family 30, which are glucosyl-ceramidases, has moderate similarity to acid beta glucosidase (mouse Gba), which hydrolyzes glucosylceramide and plays a role in the function of the epithelial permeability barrier glucosylceramidase C33C12.4 C33C12.4 Protein of unknown function, has high similarity to uncharacterized C. elegans Y54G2A.15, which may be anchored to the membrane of a secretory vesicle or the Golgi apparatus C33C12.5 C33C12.5 Protein containing an F-box domain, which serve as a link between a target protein and a ubiquitin-conjugating enzyme This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins; its encoded protein also contains a Pfam-B45 motif of presently unknown function. C33C12.6 C33C12.6 Member of the C. elegans Srb family of receptor-like integral membrane proteins, has high similarity to uncharacterized C. elegans SRB-3 C33C12.7 C33C12.7 Protein of unknown function, predicted to contain a glycosylphosphatidylinositol (GPI) lipid anchor C33C12.8 C33C12.8 Member of the glycosyl hydrolase family 30, which are glucosyl-ceramidases, has moderate similarity to acid beta glucosidase (mouse Gba), which hydrolyzes glucosylceramide and plays a role in the function of the epithelial permeability barrier glucosylceramidase C33C12.9 C33C12.9 Protein of unknown function, has high similarity to uncharacterized human N6AMT1 C33D12.1 ceh-31;C33D12.1 Protein containing a homeobox domain (homeodomain), which are found in transcription factors homeobox protein; ceh-31 encodes a protein containing a homeobox domain. C33D12.2 C33D12.2 Protein containing a DUF21 domain of unknown function, has low similarity to a region of S. cerevisiae Ami3p, which is required for normal mitochondrial structure C33D12.2 encodes a homolog of human ACDP1-ACDP4 and a paralog of C01H6.6, C52D10.12, M02F4.3, R04E5.2, and R13G10.4; both C33D12.2 and ACDP1-ACDP4 belong to a family of proteins (defined by NCBI as KOG2118) that are predicted to be membrane-spanning and that share a motif (the 'ACD domain') with proteins from bacteria, yeast, plants, and metazoa; murine Acdp1 is a plasma membrane protein bacterial proteins containing the ACD domain include CorC from Salmonella typhimurium, which is involved in magnesium and cobalt efflux; C33D12.2 has no obvious function in RNAi assays. C33D12.3 twk-3;C33D12.3;M02F4 Member of the 4 TM potassium channel protein family C33D12.6 C33D12.6 Member of the Ras superfamily of GTP-binding proteins, contains two EF hand domains, which are found in signaling, buffering or transport proteins, has a region of moderate similarity to RAB GTPase 1B (human RAB1B), which is involved in protein transport calcium-binding protein C33D12.7 ceh-30;C33D12.7 Protein containing a homeobox domain (homeodomain), which are found in transcription factors, has a region of moderate similarity to a region of bar H like homeobox 2 (mouse Barx2), which is a transcription factor that acts as an activator or repressor homeobox protien; ceh-30 encodes a homeodomain protein most similar to Drosophila and mammalian BarH1 (OMIM:605211) which function in neuronal cell fate determination; the precise biological role of CEH-30 in C. elegans development and/or behavior is not yet known. C33D3.1 elt-2;C33D3.1 Zinc-finger DNA binding factor involved in development of the gut zinc finger protein (GATA type); elt-2 encodes a GATA-type transcription factor most similar to the vertebrate GATA4-6 transcription factors required for cardiac and endoderm development (OMIM:601656, 600576); in C. elegans, ELT-2 is required redundantly with ELT-7 for initiating and maintaining terminal differentiation of the intestine; ELT-2 is expressed solely in the intestine, beginning embryonically at the 2E-cell stage and continuing in all intestinal cells throughout the life of the animal; in the regulatory hierarchy controlling endoderm development, ELT-2 lies downstream of the maternal regulators SKN-1 and POP-1 and the embryonic GATA factors MED-1/-2, and END-1/-3; in turn, ELT-2, along with ELT-7, likely regulates transcription of a number of intestine-specific terminal differentiation genes such as ges-1, ifb-2, pha-4, and the stress-induced mtl-2; ELT-2 also positively autoregulates, presumably to ensure maintenance of intestinal differentiation. C33D3.3 C33D3.3 Protein of unknown function C33D3.4 C33D3.4 Protein of unknown function, has weak similarity to C. elegans Y39A1A.17 C33D9.1 exc-5;fgd-1;C33D9.1 Putative RhoGEF domain protein; putative ortholog of H. sapiens FGD1 gene product, the mutation of which leads to faciogenital dysplasia (Aarskog-Scott syndrome) PH (pleckstrin homology) domain; The exc-5 gene encodes a homolog of human FGD1, which when mutated leads to Aarskog-Scott syndrome (OMIM:305400). C33D9.2 C33D9.2 Member of the C-type lectin family C-lectin binding domain C33D9.3 C33D9.3 Protein of unknown function C33D9.4 C33D9.4 Protein containing a DUF215 domain of unknown function, has high similarity to uncharacterized C. elegans R07B5.6 C33D9.5 C33D9.5 Putative coiled-coil protein, has similarity to human CENPE protein, centromere protein E Yeast RAD50 like protein C33D9.6 C33D9.6 Putative ortholog of C. elegans C33D9.9 gene product C33D9.8 C33D9.8 Putative coiled-coil protein, has weak similarity to myosin heavy chains C33D9.9 C33D9.9 Putative ortholog of C. elegans C33D9.6 gene product C33E10.1 C33E10.1 Protein containing an F-box domain, which serve as a link between a target protein and a ubiquitin-conjugating enzyme, has high similarity to uncharacterized C. elegans F40F4.1 This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins; its encoded protein also contains a Pfam-B45 motif of presently unknown function. C33E10.10 C33E10.10 Putative ortholog of C. elegans T25G12.2 gene product C33E10.2 C33E10.2 Protein containing a DUF38 domain of unknown function and an F-box domain, which serve as a link between a target protein and a ubiquitin-conjugating enzyme, has moderate similarity to C. elegans FOG-2 This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins; this gene's encoded protein also contains an FTH/DUF38 motif, which may also mediate protein-protein interaction. C33E10.5 C33E10.5 Protein of unknown function C33E10.6 C33E10.6 Putative ortholog of C. elegans ZC53.4 gene product C33E10.8 C33E10.8 Protein of unknown function, has weak similarity to C. elegans C52E2.I This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins. C33F10.1 C33F10.1 Protein of unknown function, has strong similarity to uncharacterized C. elegans C33F10.11 C33F10.10 C33F10.10 Protein with moderate similarity to C. elegans F11G11.9 gene product C33F10.11 C33F10.11 Protein of unknown function, has strong similarity to uncharacterized C. elegans C33F10.1 C33F10.12 C33F10.12 Member of the mitochondrial carrier protein family of membrane transporters, has moderate similarity to S. cerevisiae Mir1p, which is a phosphate transporter mitochondrial phosphate carrier protei C33F10.13 C33F10.13 Protein with strong similarity to C. elegans T27E9.8 gene product C33F10.2 C33F10.2 Protein containing two protein kinase domains and a TBC domain, has low similarity to uncharacterized human MGC16169 Cell division control protein C33F10.4 C33F10.4 Putative ortholog of C. elegans C33F10.3 gene product C33F10.5 C33F10.5 Protein with similarity to neural cell adhesion molecules involved in axon guidance; putative member of Ig superfamily fibronectin, IG-like domains of NCAM C33F10.7 C33F10.7 Protein of unknown function, has moderate similarity to uncharacterized C. elegans ZK945.1 esterase and beta-lactamase C33F10.8 C33F10.8 Member of the protein-tyrosine phosphatase family, which are involved in control of cell growth, proliferation, differentiation, has a region of low similarity to a region of human PTPN7, which is a non-receptor protein tyrosine phosphatase protein tyrosine phosphatase; This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins; its encoded protein also contains a Pfam-B45 motif of presently unknown function. C33F10.9 msp-40;C33F10.9 Member of the major sperm protein family major sperm protein; msp-40 encodes a protein that belongs to a family of proteins called the Major Sperm Proteins (MSPs) that is conserved in nematodes; this family consists of closely related, small, basic proteins that make up 15% of sperm protein; this multigene family consists of over fifty genes, including many pseudogenes; MSPs are involved in both extracellular signaling and cytoskeletal functions during reproduction-MSP antagonizes Eph/ephrin signaling, in part, by binding VAB-1 Eph receptor tyrosine kinase on oocytes and sheath cells to promote oocyte maturation and MAPK activation; MSPs assemble into fibrous networks that drive movement of the C. elegans sperm; msp genes are expressed only in late primary spermatocytes. C33G3.1 dyc-1;C33G3.1 Protein containing a phosphotyrosine interaction domain (PTB or PID), which bind various activated tyrosine-phosphorylated receptors dyc-1 encodes a homolog of murine CAPON, a protein associated with neuronal nitric oxide synthase that regulates its interactions with PSD95; DYC-1 is expressed in muscle, and is required for a dystrophin-related function in muscle. C33G3.3 C33G3.3 Protein containing a neurotransmitter-gated ion-channel ligand binding domain, has low similarity to uncharacterized C. elegans Y74E4A.1 C33G3.4 C33G3.4 Protein containing a glycosyl hydrolases family 2 sugar binding domain, has low similarity to mannosidase beta A lysosomal (beta mannosidase, human MANBA), which catalyzes the removal of N-linked mannose residues and is associated with beta-mannosidosis beta-mannosidase; C33G3.4 is orthologous to the human gene BETA-MANNOSIDASE (MANBA; OMIM:248510), which when mutated leads to disease. C33G3.5 C33G3.5 Protein of unknown function, has low similarity to uncharacterized C. elegans F18E9.7 C33G3.6 C33G3.6 Protein of unknown function, has weak similarity to a number of S. cerevisiae proteins, contains a possible coiled-coil domain C33G8.1 C33G8.1 Protein of unknown function, has moderate similarity to uncharacterized C. elegans C44C3.2 7TM chemoreceptor, srw family C33G8.10 C33G8.10 Protein containing a nuclear hormone receptor ligand-binding domain, has high similarity to uncharacterized C. elegans C33G8.9 zinc finger portein C33G8.11 C33G8.11 Protein containing a nuclear hormone receptor C4-type zinc finger domain, which bind DNA, and a nuclear hormone receptor ligand-binding domain, has a region of low similarity to a region of retinoic acid receptor gamma (mouse Rarg) nuclear hormone receptor; nhr-107 encodes a member of the nuclear hormone receptor family. C33G8.12 C33G8.12 Protein containing a nuclear hormone receptor ligand-binding domain, has high similarity to uncharacterized C. elegans C33G8.8 nuclear hormone receptor C33G8.13 C33G8.13 Putative ortholog of C. elegans C13A2.9 gene product C33G8.2 C33G8.2 Protein with moderate similarity to C. elegans Y76G2B.C gene product C33G8.3 C33G8.3 Protein of unknown function, has weak similarity to S. cerevisiae Slz1p, a sporulation-specific protein C33G8.4 C33G8.4 Protein of unknown function, has high similarity to uncharacterized C. elegans F20A1.1 C33G8.5 C33G8.5 Protein of unknown function, has moderate similarity to an uncharacterized G protein-coupled receptor (C. elegans F59A7.3) 7TM chemoreceptor, srab family C33G8.6 nhr-42;C33G8.6 Member of the nuclear hormone receptor/Zinc finger protein family zinc finger protein C33G8.7 C33G8.7 Protein containing a nuclear hormone receptor ligand-binding domain and a nuclear hormone receptor C-4 type zinc finger domain, has weak similarity to a region of hepatocyte nuclear factor 4 alpha (rat Hnf4a), which is a transcription factor zinc finger protein C33G8.8 C33G8.8 Protein containing a nuclear hormone receptor ligand-binding domain, has high similarity to uncharacterized C. elegans C33G8.10 zinc finger protein C33G8.9 C33G8.9 Protein containing a nuclear hormone receptor C4-type zinc finger domain, which bind DNA and may be involved in regulation of transcription, and a nuclear hormone receptor ligand-binding domain, has high similarity to uncharacterized C. elegans C33G8.10 zinc finger protein C33H5.1 C33H5.1 Member of the domain of unknown function DUF13 family, has high similarity to uncharacterized C. elegans K01D12.1 C33H5.10 C33H5.10 Protein of unknown function C33H5.11 C33H5.11 Protein with weak similarity to C. elegans T05E11.5 gene product C33H5.12 rsp-6;srp-1;CeSRp20;C33H5.12 SR protein involved in mRNA splicing RNA binding protein C33H5.13 C33H5.13 Protein of unknown function C33H5.14 C33H5.14 Putative uridine diphosphatase, member of the GDA1/CD39 (nucleoside phosphatase) protein family C33H5.15 C33H5.15 Protein of unknown function C33H5.16 C33H5.16 Protein with high similarity to C. elegans F10G8.1, which is involved in embryogenesis or morphogenesis, member of the protein-tyrosine phosphatase family, which are involved in control of cell growth, proliferation, differentiation and transformation protein-tyrosine phophatase C33H5.17 C33H5.17 Protein containing a CCCH-type zinc finger domain, which bind DNA or RNA, and a G-patch domain, which are found in RNA processing proteins, has weak similarity to uncharacterized human KIAA1847 C33H5.18 C33H5.18 Putative ortholog of C. elegans C33H5.18A gene product CDP-diacylglycerol synthase; C33H5.18 encodes a CDP-diglyceride synthetase ortholog required for locomotion and osmoregulation; given its biochemical function in other organisms, C33H5.18 is expected to catalyse synthesis of cytidine diphosphate-diacylglycerol (CDP-DAG), an activated precursor for anionic and zwitterionic phospholipids, and is likely to regulate phosphatidylinositol lipid signalling; one might expect loss of C33H5.18 function to be lethal, but its deficiency may be supplemented by lipids in food. C33H5.19 C33H5.19 Protein of unknown function C33H5.2 C33H5.2 Protein containing a DUF23 domain of unknown function, has high similarity to uncharacterized C. elegans F49C12.5 C33H5.3 C33H5.3 Protein with moderate similarity to C. elegans klp-18 gene product C33H5.4 klp-10;C33H5.4 Protein containing a kinesin domain, which binds ATP and microtubules, has low similarity to kinesin family member 3a (mouse Kif3a), which is a motor protein that acts in intracellular organelle transport and determination of embryonic body patterning klp-10 encodes a kinesin-like motor protein that displays similarity to diverse types of kinesin motor domains such as those found in C. elegans OSM-3, the vertebrate CHO1/MKLP proteins, and Saccharomyces cerevisiae Kip3; KLP-10 is required for embryogensis, may play a role in meiosis, and has been implicated in chromosome segregation and cell cycle progression. C33H5.6 C33H5.6 Protein containing four WD domains (WD-40 repeats), which may mediate protein-protein interactions, has moderate similarity to uncharacterized C. elegans C33H5.7 C33H5.7 C33H5.7 Protein containing four WD domains (WD-40 repeats), which may mediate protein-protein interactions, has low similarity to uncharacterized C. albicans Orf6.3607p C33H5.8 C33H5.8 Protein containing two TPR (tetratrico peptide repeat) domains, which may mediate protein-protein interactions, has low similarity to uncharacterized C. albicans Orf6.8272p C33H5.9 C33H5.9 Putative ortholog of human brain secretory protein hSec10p (HSEC10, Hs.29494) C34B2.1 C34B2.1 Protein of unknown function C34B2.10 C34B2.10 Protein of unknown function C34B2.11 C34B2.11 Protein of unknown function C34B2.2 C34B2.2 Protein of unknown function, has similarity to S. cerevisiae Ylr254p, has similarity to a region of S. cerevisiae Zip1p (component of the synaptonemal complex) C34B2.3 C34B2.3 Protein with low similarity to C. elegans Y106G6E.6, which is a serine-threonine protein kinase protein kinase C34B2.4 C34B2.4 Protein containing two LIM domains, which may mediate protein-protein interactions, has moderate similarity to a region of z-band alternatively spliced PDZ-motif protein (human LDB3), which is a Z-band component that interacts with alpha-actinin-2 C34B2.5 C34B2.5 Protein of unknown function, has moderate similarity to a region of tetratricopeptide repeat domain 1 (human TTC1), which interacts with the GAP-related domain of neurofibromin (NF1) and may be involved in protein folding C34B2.6 C34B2.6 Protein with high similarity to protease serine 15 (human PRSS15), which is a mitochondrial peptidase that binds single-stranded DNA, member of the ATPase family associated with various cellular activities, contains an ATP-dependent serine protease domain protease; This gene encodes a protein predicted by Eisenberg and coworkers, with 52% accuracy, to be mitochondrial. C34B2.7 C34B2.7 Protein with high similarity to succinate dehydrogenase complex subunit A (human SDHA), which is an electron transporter associated with Leigh syndrome, contains fumarate reductase or succinate dehydrogenase flavoprotein C-terminal and FAD binding domains flavoprotein; This gene encodes a protein predicted by Eisenberg and coworkers, with 52% accuracy, to be mitochondrial. C34B2.8 C34B2.8 Protein of unknown function C34B2.9 C34B2.9 Protein of unknown function C34B4.1 C34B4.1 Protein with weak similarity to H. sapiens MYO7A (myosin VIIA (Usher syndrome 1B (autosomal recessive, severe))) PH (pleckstrin homology) domain C34B4.2 C34B4.2 Protein containing an activin type I or II receptor domain, which are found in the extracellular region of some growth factor receptors Activin types I and II receptor domain C34B7.1 C34B7.1 Putative ortholog of S. cerevisiae Esa1p, a histone acetyltransferase and member of the MYST family The C34B7.1 gene encodes a divergent MYST acetyltransferase that is (apparently) unique to Caenorhabditis; it has no well-characterized orthologs in the complete Drosophila or S. cerevisiae genomes, and no obvious orthologs in the draft human genome sequence either. C34B7.2 C34B7.2 Protein containing a SacI homology domain, has a region of low similarity to suppressor of actin 1 (rat Sacm1l), which is an integral membrane lipid phosphatase that acts on PI 3 phosphate, PI 4 phosphate, and PI 3,5 bisphosphate Yeast hypothetical protein YNOD like C34B7.3 C34B7.3 Member of the cytochrome P450 family, has low similarity to cytochrome P450 2c29 (mouse Cyp2c29), which is a major cannabinoid metabolizing enzyme in liver microsomes and is involved in detoxification of other xenobiotics and drugs cytochrome P450 C34B7.4 C34B7.4 Putative ortholog of C. elegans VC5.4 gene product C34C12.1 C34C12.1 Putative ortholog of C. elegans Y47H9C.9 gene product C34C12.2 C34C12.2 Protein containing two coiled-coil domains, has weak similarity to S. cerevisiae Abp1p and Net1p C34C12.3 C34C12.3 PP2A-type serine/threonine protein phosphatase PROTEIN PHOSPHATASE C34C12.4 C34C12.4 Protein of unknown function C34C12.5 C34C12.5 Protein with high similarity to ras suppressor 1 (human RSU1), which may suppress v-Ras transformation and may be involved in Ras signal transduction, contains seven leucine rich repeats, which mediate protein-protein interactions RSP1 protein C34C12.6 C34C12.6 Protein containing a CRAL-TRIO domain, has weak similarity to uncharacterized C. elegans T03F7.7 C34C12.7 C34C12.7 Protein of unknown function that may be anchored to the membrane of a secretory vesicle or the Golgi apparatus C34C12.8 C34C12.8 Protein with high similarity to stress-inducible chaperone mt-GrpE#1 (rat GrpE#1), which is a mitochondrion-specific nucleotide-exchange factor chaperone that stimulates the ATPase activity of mitochondrial rat Hsp70, member of the GrpE family GRPE protein; This gene encodes a protein predicted by Eisenberg and coworkers, with 52% accuracy, to be mitochondrial. C34C6.1 C34C6.1 Member of the C. elegans Srg family of integral membrane proteins, which may be involved in chemosensation, has high similarity to uncharacterized C. elegans F15A4.4 G-protein coupled receptor, srg family C34C6.2 C34C6.2 Protein of unknown function C34C6.3 C34C6.3 Protein with strong similarity to C. elegans C09F9.2 gene product EGF receptor/notch-like protein C34C6.4 C34C6.4 Member of the GMC oxidoreductase family of FAD-containing proteins, has low similarity to glucose oxidase (A. niger Ggox), which is induced by calcium carbonate choline dehydrogenase C34C6.5 C34C6.5 Putative sphingosine kinase Diacylglycerol kinase catalytic domain (presumed) C34C6.6 pex-5;C34C6.6 Strongly similar to human peroxisome receptors and S. cerevisiae Pex5p, a receptor for the peroxisomal target signal type I, PTS1 peroxisomal-like protein; prx-5 encodes an ortholog of the human receptor for type I peroxisomal targeting signal protein, PXR1 (or PEX5; OMIM:600414), which when mutated leads to neonatal adrenoleukodystrophy or Zellweger syndrome; PXR1 protein is a component of the peroxisomal import machinery known to exist in organisms like yeast, plants and mammals. C34C6.7 C34C6.7 Protein of unknown function C34C6.8 ceh-7;C34C6.8 Homeodomain transcription factor, has similarity over the homeodomain to many human and D. melanogaster homeodomain transcription factors Homeobox domain; ceh-7 encodes a homeodomain transcription factor; expressed in cells around the rectum of the male tail. C34D1.1 C34D1.1 Protein containing one DM (dsx and mab-3) DNA binding domain DM DNA binding domain C34D1.2 C34D1.2 Protein containing one DM (dsx and mab-3) DNA binding domain, has a region of moderate similarity to a region of C. elegans MAB-3, which is required for sex-specific production of yolk proteins and male tail development DM DNA binding domain C34D1.3 odr-3;C34D1.3 G-protein alpha subunit protein required for signal transduction from ODR-10 diacetyl receptor in sensory neurons guanine nucleotide-binding protein C34D1.4 C34D1.4 Protein of unknown function C34D1.5 C34D1.5 Protein containing a bZIP (basic-leucine zipper) transcription factor domain Basic region plus leucine zipper transcription factors C34D10.1 C34D10.1 Protein containing a major sperm protein (MSP) domain, which are involved in sperm motility, has moderate similarity to uncharacterized human DJ473B4 C34D10.2 C34D10.2 Protein containing three CCCH-type zinc finger domains, which bind DNA or RNA Cys(3)His finger protein (D. melanogaster) C34D4.1 C34D4.1 Putative ortholog of C. elegans C42D4.7 gene product C34D4.10 C34D4.10 Protein of unknown function C34D4.11 C34D4.11 Protein of unknown function C34D4.12 C34D4.12 Protein with high similarity to C. elegans CYP-10, which is a cyclophilin-related peptidylprolyl cis-trans-isomerase, member of the cyclophilin type peptidyl-prolyl cis-trans isomerase family cyp-12 encodes a member of the cyclophilin family. C34D4.13 C34D4.13 Protein of unknown function C34D4.14 C34D4.14 Protein containing two ankyrin repeats, which may mediate protein-protein interactions, and a HECT domain, which may confer ubiquitin-protein ligase activity, has a region of low similarity to a region of S. cerevisiae Ufd4p C34D4.15 C34D4.15 Protein containing two collagen triple helix repeats, which are found in some extracellular proteins, and a nematode cuticle collagen N-terminal domain, has low similarity to C. elegans SQT-1, which is a collagen C34D4.2 C34D4.2 PP1-type serine/threonine protein phosphatase C34D4.3 C34D4.3 Protein containing a major sperm protein (MSP) domain, which are involved in sperm motility, has high similarity to uncharacterized C. elegans ZK1307.3 C34D4.4 C34D4.4 Protein of unknown function, has low similarity to uncharacterized C. albicans Orf6.7349p C34D4.5 C34D4.5 Member of the reverse transcriptase protein family, which are RNA-dependent DNA polymerases, has high similarity to uncharacterized C. elegans F56C9.2 C34D4.8 C34D4.8 Member of the 7-transmembrane chemoreceptor family of G protein-coupled receptors (GPCR), has low similarity to C. elegans ODR-10, which is a G protein-coupled receptor involved in odorant response 7TM chemoreceptor, str family C34D4.9 C34D4.9 Member of the astacin (M12A) family of metalloproteases, has a region of moderate similarity to a region of the beta subunit of meprin A (rat Mep1b), which is an integral membrane protein that may play a role in embryogenesis C34E10.1 gop-3;C34E10.1 Protein of unknown function, has low similarity to uncharacterized human CGI-51 gop-3 encodes an ortholog of the mammalian CGI-51 (comparative gene identification-51) proteins that display a high degree of similarity to the Haemophilus influenza D15 protective surface antigen; loss of gop-3 activity via large-scale RNAi screens indicates that GOP-3 is required for embryonic and larval development, as well as for normal postembryonic growth rates. C34E10.10 C34E10.10 Protein with moderate similarity to C. elegans F30A10.9 gene product C34E10.11 C34E10.11 Protein of unknown function C34E10.2 gop-2;C34E10.2 Member of the Ylr243p/Yor262p-like protein family gop-2 encodes a member of the conserved hypothetical ATP binding protein family that affects embryonic viability, growth, and fertility. C34E10.3 gop-1;C34E10.3 Protein of unknown function, has low similarity to uncharacterized human KIAA0350 C34E10.4 C34E10.4 Member of the class I tryptophanyl and tyrosyl (W and Y) tRNA synthetase family, contains a C3HC4 type (RING) zinc finger, which may mediate protein-protein interactions, has a region of moderate similarity to tryptophanyl tRNA synthetase 2 (human WARS2) wrs-2 encodes a tryptophanyl (W) tRNA synthetase predicted to be mitochondrial. C34E10.5 C34E10.5 Protein with low similarity to protein arginine methyltransferase 5 (human PMRT5), which methylates target proteins on arginine residues and may inhibit mitosis C34E10.6 atp-2;C34E10.6 Protein with strong similarity to beta subunit of mitochondrial F1 ATP synthase (human ATP5B), contains two ATP synthase alpha or beta family nucleotide-binding and C-terminal domains and two beta-barrel domains ATP synthase beta chain; atp-2 encodes the ATP synthase beta (active site) subunit of mitochondrial respiratory chain (MRC) complex V; ATP-2 is required for normal mobility, pharyngeal pumping, defecation, growth, and lifespan, and is also required for development past the third larval stage. C34E10.7 cnd-1;C34E10.7 Protein containing one helix-loop-helix DNA-binding domain, which mediate protein dimerization, has moderate similarity to a region of neurogenic differentiation protein 1 (rat Neurod1), which is a transcription factor regulating neuronal differentiation cnd-1 is orthologous to the human gene NEUROGENIC DIFFERENTIATION 1 (NEUROD1; OMIM:601724), which when mutated leads to disease. C34E10.8 C34E10.8 Protein of unknown function C34E10.9 C34E10.9 Protein of unknown function C34E11.1 C34E11.1 Protein containing an epsin N-terminal homology (ENTH) domain, has low similarity to epsin 1 (human EPSIN), which is a component of a multi-protein complex that plays a role in clathrin-mediated endocytosis yeast hypothetical L8167.6 like C34E11.2 C34E11.2 Protein of unknown function C34E11.3 C34E11.3 Putative coiled-coil protein, has similarity to S. cerevisiae Msp1p, a myosin-like protein C34E7.1 C34E7.1 Protein of unknown function, has weak similarity to human KIAA0181, a CAG repeat-containing protein (Hs.159613) The protein product of this gene is predicted to contain a glutamine/asparagine (Q/N)-rich ('prion') domain, by the algorithm of Michelitsch and Weissman (as of the WS77 release of WormBase, i.e., in wormpep77). C34E7.2 C34E7.2 Protein of unknown function C34E7.3 C34E7.3 Protein of unknown function C34E7.4 C34E7.4 Protein with moderate similarity to C. elegans C05E7.2 gene product C34F11.1 C34F11.1 Protein with moderate similarity to C. elegans T24D1.3 gene product C34F11.2 C34F11.2 Protein of unknown function, has high similarity to uncharacterized C. elegans Y73F8A.14 C34F11.3 C34F11.3 Protein with high similarity to adenosine monophosphate deaminase 2 (isoform L) (human AMPD2), which catalyzes the deamination of adenosine monophosphate in purine nucleotide metabolism, member of the adenosine and AMP deaminase family AMP deaminase C34F11.4 msp-50;C34F11.4 Member of the major sperm protein family major sperm protein; msp-50 encodes a protein that belongs to a family of proteins called the Major Sperm Proteins (MSPs) that is conserved in nematodes; this family consists of closely related, small, basic proteins that make up 15% of sperm protein; this multigene family consists of over fifty genes, including many pseudogenes; MSPs are involved in both extracellular signaling and cytoskeletal functions during reproduction-MSP antagonizes Eph/ephrin signaling, in part, by binding VAB-1 Eph receptor tyrosine kinase on oocytes and sheath cells to promote oocyte maturation and MAPK activation; MSPs assemble into fibrous networks that drive movement of the C. elegans sperm; msp genes are expressed only in late primary spermatocytes. C34F11.5 C34F11.5 Protein containing a Src homology 2 (SH2) domain and a protein kinase domain, has weak similarity to thousand and one amino acid protein kinase (rat Tao1), which is involved in regulating the p38-containing stress responsive MAP kinase pathway tyrosine-protein kinase C34F11.6 msp-49;C34F11.6 Member of the major sperm-specific protein (MSP) family major sperm protein; msp-49 encodes a protein that belongs to a family of proteins called the Major Sperm Proteins (MSPs) that is conserved in nematodes; this family consists of closely related, small, basic proteins that make up 15% of sperm protein; this multigene family consists of over fifty genes, including many pseudogenes; MSPs are involved in both extracellular signaling and cytoskeletal functions during reproduction-MSP antagonizes Eph/ephrin signaling, in part, by binding VAB-1 Eph receptor tyrosine kinase on oocytes and sheath cells to promote oocyte maturation and MAPK activation; MSPs assemble into fibrous networks that drive movement of the C. elegans sperm; msp genes are expressed only in late primary spermatocytes. C34F11.8 C34F11.8 Protein of unknown function C34F11.9 C34F11.9 Protein containing 3 PDZ, DHR, or GLGF domains, 3 dishevelled specific domains, 2 DIX or DAX (dishevelled and axin) domains, and 3 domains of unknown function, has moderate similarity to dishevelled 1 (human DVL1), which is in the Wnt and Notch pathways dishevelled-like protein; dsh-1 encodes a homolog of Drosophila DISHEVELED and a paralog of MIG-5 (and DSH-2); DSH-1 appears to be required for Wnt-induced endoderm specification in the EMS blastomere, and may influence HSN migration as well. C34F6.1 C34F6.1 Protein containing eight kunitz or bovine pancreatic trypsin inhibitor domains, has a region of low similarity to tissue factor pathway inhibitor (human TFPI), which inhibits factor Xa and factor VIIa-tissue factor complex to prevent fibrin clot formation Kunitz/Bovine pancreatic trypsin inhibitor domain (8 domains) C34F6.10 C34F6.10 Protein containing four fibronectin type III domains, which are involved in cell surface binding Fibronectin type III domain (4 domains) C34F6.2 C34F6.2 Protein containing two collagen triple helix repeats, which are found in some extracellular proteins, and a nematode cuticle collagen N-terminal domain, has a region of high similarity to a region of human COL6A1, which is associated with Bethlem myopathy collagen C34F6.3 C34F6.3 Protein containing two collagen triple helix repeats, which are found in some extracellular proteins, has a region of high similarity to a region of collagen type VI, alpha 1 (human COL6A1), which is associated with Bethlem myopathy upon gene mutation collagen C34F6.4 C34F6.4 Protein of unknown function, has a region of high similarity to heparan sulfate 2-O-sulfotransferase 1 (mouse Hs2st1), which is a sulfotransferase enzyme that plays a role in heparan sulfate proteoglycan biosynthesis and kidney development C34F6.5 C34F6.5 Protein of unknown function C34F6.6 C34F6.6 Protein of unknown function C34F6.7 C34F6.7 Protein of unknown function C34F6.8 C34F6.8 Protein with high similarity to mouse Idh2, which is a mitochondrial isocitrate dehydrogenase, member of the isocitrate and isopropylmalate dehydrogenase family, which are oxidoreductases involved in metabolism Isocitrate and isopropylmalate dehydrogenases C34F6.9 C34F6.9 Protein with weak similarity to C. elegans T22F3.2 gene product Ubiquitin carboxyl-terminal hydrolases family 2 C34G6.1 C34G6.1 Protein with moderate similarity to D. melanogaster c11.1 (Protein of unknown function) C34G6.2 C34G6.2 Protein containing two tyrosinase central domains, which are copper-binding domains, has a region of low similarity to a region of tyrosinase (human TYR), which is required for melanin synthesis and is associated with type I oculocutaneous albinism C34G6.3 C34G6.3 Protein of unknown function, has strong similarity to uncharacterized C. elegans Y67A6A.1 C34G6.4 pgp-2;C34G6.4 P-glycoprotein, multidrug resistance protein of the ATP-binding cassette (ABC) superfamily, has strong similarity to human, Drosophila, and S. cerevisiae multidrug resistance proteins abc transporter; pgp-2 encodes a member of the ABC transporter family with highest similarity to the vertebrate MDR (multidrug resistance) family, and is orthologous to human MDR1 (ABCB1; OMIM:171050, mutated in Crohn disease); PGP-2 is expressed at lower levels during the embryonic stages with higher expression later in development. C34G6.5 C34G6.5 Protein containing a protein kinase domain, has low similarity to S. cerevisiae Cdc7p, which is a protein kinase that interacts with S. cerevisiae Dbf4p to affect DNA synthesis initiation, commitment to sporulation, DNA repair, and meiotic recombination ser/thr-protein kinase C34G6.6 C34G6.6 Member of an uncharacterized protein family C34G6.7 C34G6.7 Protein containing a Src homology 3 (SH3) domain, a ubiquitin interaction motif, and a VHS domain of unknown function, has low similarity to signal transducing adaptor molecule 1 (human STAM), which is involved in signal transduction The protein product of this gene is predicted to contain a glutamine/asparagine (Q/N)-rich ('prion') domain, by the algorithm of Michelitsch and Weissman (as of the WS77 release of WormBase, i.e., in wormpep77). C34H3.1 C34H3.1;mig-17 Protein with moderate similarity to C. elegans F27D9.7 C34H3.2 C34H3.2 Protein with strong similarity to D. melanogaster odd (odd skipped) C2H2-type zinc finger protein; odd-2 encodes a protein with homology to the Drosophila ODD-SKIPPED family members and affects larval viability; expressed in the intestine. C34H4.1 C34H4.1 Protein predicted to contain a glycosylphosphatidylinositol (GPI) lipid anchor C34H4.2 C34H4.2 Protein of unknown function, has moderate similarity to uncharacterized C. elegans K11H12.4 C34H4.3 C34H4.3 Protein of unknown function, has low similarity to uncharacterized C. elegans K11H12.4 C34H4.4 C34H4.4 Protein containing a collagen triple helix repeat, which are found in some extracellular proteins, and a nematode cuticle collagen N-terminal domain, has a region of moderate similarity to a region of C. elegans BLI-1 cuticular collagen C35A11.1 C35A11.1 Member of the rhodopsin family of G protein-coupled receptors (GPCR), has moderate similarity to uncharacterized C. elegans D1069.4 C35A11.2 C35A11.2 Protein of unknown function C35A11.3 C35A11.3 Protein of unknown function, has high similarity to uncharacterized C. elegans F49C5.7 C35A11.4 C35A11.4 Member of the hexose transporter family of the major facilitator superfamily [MFS] sugar transporter C35A5.1 C35A5.1 Member of the major intrinsic protein (MIP) family, which are transmembrane channels, has moderate similarity to C. elegans AQP-CE2, which is a mercury-sensitive water channel protein tonoplast channel protein C35A5.2 C35A5.2 Protein containing a UDP-glucoronosyl and UDP-glucosyl transferase domain, which transfer glycosyl groups to small hydrophobic molecules, has low similarity to UDP glycosyltransferase 1 family polypeptide A1 (human UGT1A) UDP-glucuronosyltransferase C35A5.3 C35A5.3 Protein with similarity to human and D. melanogaster sodium-dependent inorganic phosphate cotransporters, member of the major facilitator superfamily sodium/phosphate transport protein C35A5.4 C35A5.4 Protein containing a major sperm protein (MSP) domain, which are involved in sperm motility C35A5.5 C35A5.5 Protein containing a DUF23 domain of unknown function C35A5.6 C35A5.6 Protein of unknown function C35A5.7 C35A5.7 Protein of unknown function, has low similarity to uncharacterized C. elegans F57B7.1 transmembranous domains C35A5.8 C35A5.8 Protein with moderate similarity to ran-binding protein 16 (human RANBP16), which binds to Ran-GTP and may regulate Ran function and act as a nuclear transport protein C35A5.9 C35A5.9 Member of the histone deacetylase family, which catalyze removal of acetyl groups from histones C35B1.1 ubc-1;C35B1.1 Type II ubiquitin-conjugating enzyme ubiquitin conjugating-protein; ubc-1 encodes an E2 ubiquitin-conjugating enzyme that contains a novel 40 amino acid C-terminal tail, and is homologous to Saccharomyces cerevisiae RAD6/UBC2 which is involved in DNA repair; although loss of UBC-1 activity via RNA-mediated interference (RNAi) does not result in any abnormalities, UBC-1 is able to complement the DNA repair defects of a Saccharomyces cerevisiae rad6 null mutant, suggesting that UBC-1 can function in the DNA repair pathway; ubc-1 mRNA is detectable in embryos. C35B1.2 C35B1.2 Protein with moderate similarity to C. elegans Y39B6A.B gene product C35B1.3 C35B1.3 Protein of unknown function C35B1.4 C35B1.4 Protein of unknown function C35B1.5 C35B1.5 Protein with high similarity to C. elegans R05H5.3, which is a putative nuclear thioredoxin involved in embryogenesis and morphogenesis C35B1.6 C35B1.6 Protein of unknown function C35B1.7 C35B1.7 Protein of unknown function C35B8.1 C35B8.1 Protein containing two collagen triple helix repeats, which are found in some extracellular proteins, and a nematode cuticle collagen N-terminal domain, has moderate similarity to a region of C. elegans BLI-1 Cuticle collagen C35B8.2 C35B8.2 Protein with strong similarity to human VAV1, VAV2, and VAV-3 (Hs.37331) proto-oncogene products vav proto-oncogene; vav-1 encodes an ortholog of the Vav proto-oncogene, a complex protein with several domains, from N- to C-terminus: a calponin-like actin-binding domain; a RhoGEF/DH domain; a pleckstrin-like domain; a SH2 motif domain; and an SH3 domain. C35B8.3 C35B8.3 Protein of unknown function C35C5.1 sdc-2;C35C5.1 Hermaphrodite specific protein involved in sex determination; directs the dosage compensation complex to X chromosome in hermaphrodites; has weak similarity to S. cerevisiae USO1 gene product The sdc-2 gene encodes a protein that represses transcription of X chromosomes to achieve dosage compensation, and that also represses the male sex-determination gene her-1 to elicit hermaphrodite differentiation. C35C5.2 C35C5.2 Putative transferrin receptor C35C5.3 C35C5.3 Protein of unknown function, has moderate similarity to uncharacterized C. elegans F28H7.4 C35C5.4 mig-2;C35C5.4 GTP-binding protein of the rho family (ras superfamily), required for normal migration of axons, neurons, and mesodermal cells during embryogenesis RAS-related protein; mig-2 encodes a member of the Rho family of GTP-binding proteins that affects the migration of Q neuroblasts, HSN cells, and CAN cells as well as axon outgrowth and guidance; it is expressed in early embryos and expressed in adults in the vulva, distal tip cells of the gonad, and the sex myoblasts and their descendants. C35C5.5 acr-13;C35C5.5 Protein containing neurotransmitter-gated ion-channel ligand binding and transmembrane domains, has low similarity to C. elegans UNC-38, which is a nicotinic acetylcholine receptor alpha subunit acetylcholine receptor C35C5.6 C35C5.6 Protein of unknown function C35C5.8 C35C5.8 Protein of unknown function, has low similarity to uncharacterized C. elegans F16C3.2 C35C5.9 C35C5.9 Protein of unknown function C35D10.1 C35D10.1 Protein that has strong similariy to a subunit of the ARP2/3 actin-organizing complex in its N-terminus C35D10.10 C35D10.10 Protein of unknown function, has moderate similarity to uncharacterized human LOC51075 C35D10.11 C35D10.11 Member of an uncharacterized protein family C35D10.12 C35D10.12 Protein of unknown function, has low similarity to uncharacterized human KIAA1456 C35D10.13 C35D10.13 Protein of unknown function C35D10.14 C35D10.14 Member of the C-type lectin family, has similarity to human C-type mannose receptor MRC1, has similarity to D. melanogaster TOLLOID and TOLKIN proteins C-type lectin domain C35D10.15 C35D10.15 Putative ortholog of C. elegans C35D10.14 gene product C35D10.16 C35D10.16 Protein of unknown function C35D10.2 C35D10.2 Putative paralog of C. elegans F44D12.4 gene product C35D10.3 C35D10.3 Protein of unknown function C35D10.4 C35D10.4 Member of the ABC1 family, has a region of moderate similarity to S. cerevisiae Abc1p, which is required for coenzyme Q biosynthesis and the activity of cytochrome bc1 complex coq-8 encodes a protein orthologous to COQ8 from S. cerevisiae and homologous to ABC1 from S. cerevisiae and AarF from E. coli; COQ-8 is required for ubiquinone biosynthesis and for normally short lifespan; the biochemical function of COQ-8 is unknown, but it may be a chaperonin; coq-8(RNAi) animals have reduced levels of coenzyme Q8, coenzyme Q9, and superoxide, and have abnormally long lifespans. C35D10.5 C35D10.5 Protein of unknown function, has low similarity to uncharacterized mouse Bfzb C35D10.6 C35D10.6 Member of the aldo-keto reductase family, which include some related monomeric NADPH-dependent oxidoreductases, has low similarity to aldose reductase (human AKR1B1), which catalyzes glucose to sorbitol reduction and contributes to diabetes complications Aldose reductase C35D10.7 C35D10.7;C35D10.7 Protein of unknown function C35D10.8 C35D10.8 Protein with moderate similarity to C. elegans Y37E11AL.2 gene product C35D10.9 ced-4;C35D10.9 Caspase-binding adapter protein required for programmed cell death The ced-4 gene encodes a protein required for apoptosis. C35D6.1 C35D6.1 Member of the 7-transmembrane chemoreceptor family of G protein-coupled receptors (GPCR), has very strong similarity to uncharacterized C. elegans C35D6.2 C35D6.2 C35D6.2 Member of the 7-transmembrane chemoreceptor family of G-protein coupled receptors (GPCR), has very strong similarity to uncharacterized C. elegans C35D6.1 C35D6.3 C35D6.3 Protein with strong similarity to C. elegans Y71A12B.3 gene product C35D6.4 C35D6.4 Protein containing two CCCH-type zinc finger domains, which bind DNA or RNA, has moderate similarity to C. elegans POS-1, which is a cytoplasmic zinc-finger protein involved in regulation of early morphogenesis Zinc finger C-x8-C-x5-C-x3-H type (and similar). (2 domains) C35D6.5 C35D6.5 Putative ortholog of C. elegans K06H6.2 gene product C35E7.1 C35E7.1 Protein with moderate similarity to C. elegans F44F1.6 gene product C35E7.10 C35E7.10 Protein containing protein kinase and Src homology 2 (SH2) domains, has moderate similarity to a region of fer (fps/fes related) tyrosine kinase (human FER), which may mediate cell-cell signaling, cytoskeletal reorganization, cell growth and cell adhesion protein kinase C35E7.11 C35E7.11 Protein of unknown function C35E7.2 C35E7.2 Protein with moderate similarity to C. elegans C35E7.3 gene product C35E7.3 C35E7.3 Protein with strong similarity to C. elegans F42G2.6 gene product C35E7.4 C35E7.4 Protein with strong similarity to C. elegans C35E7.5 gene product C35E7.5 C35E7.5 Protein with strong similarity to C. elegans C35E7.4 gene product C35E7.6 C35E7.6 Protein of unknown function, has weak similarity to C. elegans T04D3.1 C35E7.7 C35E7.7 Protein of unknown function, has weak similarity to C. elegans F56H1.2 C35E7.8 C35E7.8 Putative ortholog of C. elegans F36H12.2 gene product C35E7.9 C35E7.9 Protein containing a major sperm protein (MSP) domain, which are involved in sperm motility, has high similarity to uncharacterized C. elegans F36H12.3 C36A4.1 C36A4.1 Member of the cytochrome P450 family, has low similarity to cytochrome P450 subfamily 3A polypeptide 4 (human CYP3A4), which is a major drug metabolizing enzyme that oxidizes the calcium channel blocking drug nifedipine as well as other dihydropyridines cytochrome P450 C36A4.10 C36A4.10 Protein of unknown function C36A4.2 C36A4.2 Member of the cytochrome P450 family, has low similarity to cytochrome P450 subfamily 3A polypeptide 9 (rat Rn.10489), which demethylates erythromycin and benzphetamine and is expressed in a sexually dimorphic female specific pattern upon puberty onset cytochrome P450 C36A4.4 C36A4.4 Member of the UTP-glucose-1-phosphate uridylyltransferase family, which catalyze formation of UDP-glucose, has moderate similarity to UDP-N-acetylglucosamine pyrophosphorylase 1 (sperm associated antigen 2, human UAP1) C36A4.5 C36A4.5 Protein of unknown function, has strong similarity to uncharacterized C. elegans F25D7.4 claustrin like C36A4.6 C36A4.6 Member of the cytochrome P450 family, has low similarity to steroid inducible cytochrome P450 3a11 (mouse Cyp3a11), which is a microsomal enzyme that catalyzes oxidation of tetrahydrocannabinol compounds and may be involved in xenobiotic responses cytochrome P450 C36A4.7 C36A4.7 Member of the transposase family, which are required for excising and inserting mobile genetic elements, has very strong similarity to uncharacterized C. elegans C10H11.2 transposase C36A4.8 C36A4.8 Protein containing a C3HC4 type (RING) zinc finger, which may mediate protein-protein interactions, and a BRCA1 (breast cancer type 1) C terminus (BRCT) domain, which are found in some cell cycle checkpoint proteins Zinc finger, C3HC4 type (RING finger); The brc-1 gene encodes a homolog of human BRCA1, which when mutated leads to early onset breast and ovarian cancer (OMIM:113705). C36A4.9 C36A4.9 Protein with high similarity to acetyl-Coenzyme A synthetase 2 (acetyl-CoA synthetase, human ACAS2), which catalyzes the ATP-dependent condensation of acetate and coenzyme A to form acetyl-CoA, member of the AMP-binding enzyme family acetyl-coenzyme A synthetase C36B1.10 C36B1.10 Protein containing a protein kinase domain, has low similarity to S. pombe Skp1p, which is a serine/threonine kinase involved in cytokinesis serine/threonine kinase C36B1.11 C36B1.11 Protein of unknown function, has moderate similarity to uncharacterized C. elegans Y48G10A.2 C36B1.12 C36B1.12 Protein of unknown function, has a region of low similarity to histocompatibility 13 (mouse H13), which is a minor antigen and source of the Db MHC class I molecule presented nonapeptide that induces a cellular immune response resulting in graft rejection C36B1.3 C36B1.3 Protein with moderate similarity to S. cerevisiae Rpb3p, which is the third-largest subunit of RNA polymerase II DNA directed RNA polymerase II C36B1.4 pas-4;C36B1.4 Putative alpha-type subunit of 20S proteasome particle proteasome A-type submit C36B1.5 C36B1.5 Protein with high similarity to PRP4-STK-WD splicing factor (human HPRP4P), which is a protein kinase that associates with U4/U6 snRNP and is involved in transcriptional regulation, contains seven WD domains (WD-40 repeats) U4/U6 small nuclear ribonucleoprotein C36B1.6 C36B1.6 Protein of unknown function C36B1.7 C36B1.7 Member of the dihydrofolate reductase family, which catalyze the NADPH-dependent reduction of dihydrofolate to tetrahydrofolate, has moderate similarity to dihydrofolate reductase (human DHFR), which is associated with methotrexate resistance di-hydrofolate reductase C36B1.8 C36B1.8 Protein of unknown function C36B1.9 C36B1.9 Protein containing a C3HC4 type (RING) zinc finger, which may mediate protein-protein interactions Zinc finger, C3HC4 type (RING finger) C36B7.1 C36B7.1 Protein containing a protein kinase domain, has low similarity to P. carinii Cdc2_carinii, which is a cyclin-dependent kinase with a potential role in the cell cycle CDC2/CDC28 subfamily of ser/thr protein kinases C36B7.2 C36B7.2 Protein containing two protein kinase domains, has low similarity to a region of dual-specificity tyrosine phosphorylated and regulated kinase 3 (human DYRK3), which phosphorylates histone H2B and H3 and may function in spermatogenesis CDC2/CDC28 subfamily of ser/thr protein kinases C36B7.3 C36B7.3 Protein of unknown function C36B7.4 C36B7.4 Protein of unknown function C36B7.5 C36B7.5 Protein containing 18 type 1 thrombospondin domains and two PAN domains, has a region of low similarity to properdin P factor (human PFC), which plays a role complement-mediated clearance and natural and acquired resistance to infection type-I thrombospondin TSR repeats C36B7.6 C36B7.6 Protein of unknown function, has a region of high similarity to cleft lip and palate associated transmembrane protein 1 (mouse Clptm1), which is an antigen found on the surface of thymic epithelial cells that plays a role in T cell development C36B7.7 C36B7.7 Protein of unknown function hen-1 encodes a secretory protein that contains a low-density lipoprotein receptor class A domain and affects integration of sensory stimuli and behavioral plasticity; expressed in pharyngeal muscles, the vulva, and is weakly expressed in a subset of neurons. C36C5.1 C36C5.1 Protein of unknown function, has high similarity to uncharacterized C. elegans C36C5.2 C36C5.10 C36C5.10 Protein of unknown function, has high similarity to uncharacterized C. elegans C36C5.6 7TM chemoreceptor, srab family C36C5.11 C36C5.11 Protein of unknown function, has high similarity to uncharacterized C. elegans C36C5.6 7TM chemoreceptor, srab family C36C5.12 C36C5.12 Protein containing a DUF19 domain of unknown function, which contain twelve conserved cysteines, has high similarity to uncharacterized C. elegans T28A11.3 C36C5.13 C36C5.13 Member of the reverse trancriptase family, which are RNA-dependent DNA polymerases, contains a PHD-finger, which may be involved in chromatin-mediated transcriptional regulation C36C5.14 C36C5.14 Protein containing a DUF19 domain of unknown function, which contain twelve conserved cysteines, has high similarity to uncharacterized C. elegans C36C5.15 C36C5.15 C36C5.15 Protein containing a DUF19 domain of unknown function, which contain twelve conserved cysteines, has high similarity to uncharacterized C. elegans C36C5.14 C36C5.2 C36C5.2 Protein of unknown function, has high similarity to uncharacterized C. elegans C36C5.1 7TM chemoreceptor, srab family C36C5.3 C36C5.3 Protein containing two DUF40 domains of unknown function, which contain four conserved cysteines, has high similarity to uncharacterized C. elegans F35F10.9 C36C5.4 C36C5.4 Protein containing a DUF19 domain of unknown function, which contain twelve conserved cysteines, has high similarity to uncharacterized C. elegans T28A11.16 C36C5.5 C36C5.5 Protein containing a DUF19 domain of unknown function, which contain twelve conserved cysteines, has high similarity to uncharacterized C. elegans F10G2.1 C36C5.6 C36C5.6 Protein of unknown function, has high similarity to uncharacterized C. elegans C36C5.11 7TM chemoreceptor, srab family C36C5.7 C36C5.7 Protein of unknown function, has high similarity to uncharacterized C. elegans C36C5.6 7TM chemoreceptor, srab family C36C5.8 C36C5.8 Protein of unknown function, has high similarity to uncharacterized C. elegans C36C5.6 7TM chemoreceptor, srab family C36C5.9 C36C5.9 Protein containing a DUF32 domain of unknown function, has low similarity to uncharacterized C. elegans Y5H2B.7 7TM chemoreceptor, srt family C36C9.1 C36C9.1 Protein of unknown function, has high similarity to uncharacterized C. elegans F52D2.4 C36C9.2 C36C9.2 Protein containing a T-box domain, which bind DNA C36C9.3 C36C9.3 Protein with high similarity to C. elegans T07D3.1, which may function in germ-line stem cell differentiation, contains a DUF38 domain of unknown function and an F-box domain, which links a target protein and a ubiquitin-conjugating enzyme This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins; this gene's encoded protein also contains an FTH/DUF38 motif, which may also mediate protein-protein interaction. C36C9.4 C36C9.4 Putative ortholog of C. elegans T25D1.2 gene product C36C9.5 C36C9.5 Protein with moderate similarity to C. elegans T24E12.9 gene product C36E6.1 C36E6.1 Putative ortholog of C. elegans M01A10.1 gene product C36E6.1 encodes two proteins by alternative splicing, belonging to an ancient family of single-stranded nucleic acid-binding proteins, that are predicted to regulate gene expression through binding either mRNA or (locally) single-stranded DNA; they are most likely to specifically bind one or more discrete mRNAs and regulate their spatial localization or alternative splicing. C36E6.2 C36E6.2 Protein of unknown function C36E6.B mlc-2;C36E6.5;C36E6.B Regulatory myosin light chain, essentially identical to mlc-1 C36E6.F mlc-1;C36E6.3;C36E6.F Regulatory myosin light chain, essentially identical to MLC-2 C36E8.1 C36E8.1 Protein with low similarity to human RRN3, which is an RNA polymerase I transcription factor C36E8.2 C36E8.2 Protein with moderate similarity to C. elegans R01E6.6 gene product C36E8.3 C36E8.3 Protein of unknown function C36E8.4 C36E8.4 Protein containing two coiled-coil domains and an FCH (Fes/CIP4 homology) domain C36E8.5 C36E8.5 Protein with strong similarity to beta tubulin (C. elegans BEN-1), member of the tubulin-FtzA family, which are involved in polymer formation beta tubulin; tbb-2 encodes a homolog of mammalian beta-tubulin (TUBB) that is expressed at high levels in the germline; TBB-2 is redundant for embryonic viability, due to its paralog TBB-1; however, unlike its paralog TBB-1 it is required for normal microtubule severing by the katanin complex MEI-1/MEI-2; TBB-2 is required together with TBB-1, TBA-1, and tba-2 to make spindle structures in embryos and TBB-2 also affects the stability of the PO spindle; first divisions are normal in null mutants, but putative gain-of-function mutations affect centrosome rotations in the P0, P1, and EMS blastomeres of the early embryo, and affect pronuclear migration and meiosis. C36F7.1 C36F7.1 Protein containing a homeobox domain (homeodomain), which are found in transcription factors, has a region of moderate similarity to a region of iroquois related homeobox 1 (mouse Irx1), which is a transcription factor that may serve in heart development Homeobox domain C36F7.2 C36F7.2 Protein containing two ankyrin repeats, which may mediate protein-protein interactions C36F7.4 zig-8;C36F7.3;C36F7.4 Protein containing four immunoglobulin (Ig) domains, has a region of low similarity to a region of limbic system-associated membrane protein (rat Lsamp), which plays a role in the selective outgrowth of neurons and the targeting of axons Drosophila amalgam protein like C36F7.5 C36F7.5 Protein containing a DUF236 domain of unknown function, has strong similarity to uncharacterized C. elegans F42H11.1 C36H8.1 C36H8.1 Protein containing a major sperm protein (MSP) domain, which are involved in sperm motility, has a region of moderate similarity to C. elegans MSP-77, which is involved in oocyte maturation major sperm protein like C36H8.2 opu-6;inx-6;C36H8.2 Member of the integral membrane innexin family, which are involved in the formation of gap junctions, has low similarity to C. elegans INX-3, which is an innexin that forms connexin-like intercellular channels UNC-7 like; inx-6 encodes an innexin, an integral transmembrane channel protein that is a structural component of invertebrate gap junctions; INX-6 is required for formation of pharyngeal gap junctions and thus for the electrical coupling and synchronous muscle contractions necessary for normal feeding behavior and postembryonic development; INX-6 may function redundantly with EAT-5, another C. elegans innexin; INX-6 expression is first detected in embryonic pharyngeal precursors and during later larval and adult stages, in pharyngeal corpus muscles and isthmus marginal cells, where INX-6 localizes to plaque-like structures in the plasma membrane. C36H8.3 flp-9;C36H8.3 KPSFVRF-amide neurotransmitter flp-9 encodes a predicted FMRFamide-like peptide neurotransmitter that inhibits action potentials in the pharyngeal muscle when applied to the pharynx of dissected worms and inhibits movement when injected into A. suum; expressed at highest levels prior to adulthood. C37A2.1 C37A2.1 Protein containing a KH domain, which may bind RNA, has low similarity to etoile (mouse Etle), which is an RNA-binding protein that interacts with the RNA binding protein RBM (mouse RbmY1a1) C37A2.2 C37A2.2 Protein of unknown function, has weak similarity over central region to human NAF1 (Nef-associated factor 1) The protein product of this gene is predicted to contain a glutamine/asparagine (Q/N)-rich ('prion') domain, by the algorithm of Michelitsch and Weissman (as of the WS77 release of WormBase, i.e., in wormpep77). C37A2.3 C37A2.3 Member of the acyl-CoA dehydgrogenase protein family acyl-CoA dehydrogenase C37A2.4 cye-1;evl-10;C37A2.4 Putative cyclin E2, has strong similarity to human and D. melanogaster cyclin E proteins, has similarity to S. cerevisiae Clb proteins cyclin; cye-1 encodes a homolog of the G1 cell cycle regulator cyclin E; CYE-1 is required for progression through the G1 phase of the cell cycle and for endoreduplication in intestinal cells, and is required maternally both for embryonic development and for the proper execution of several post-embryonic lineages (e.g. vulval development); CYE-1 is provided maternally and expressed ubiquitously in nuclei during embryonic development; postembryonic expression is restricted to actively proliferating blast cells, including the germline. C37A2.5 C37A2.5 Protein containing a C2H2 type zinc finger domain, which bind nucleic acids The protein product of this gene is predicted to contain a glutamine/asparagine (Q/N)-rich ('prion') domain, by the algorithm of Michelitsch and Weissman (as of the WS77 release of WormBase, i.e., in wormpep77). C37A2.6 C37A2.6 Protein of unknown function C37A2.7 C37A2.7 Protein of the large 60S ribosomal subunit, has moderate similarity to ribosomal protein large P2 (human RPLP2), which is an acidic ribosomal protein that contains an antigen which generates autoantibodies in individuals with systemic lupus erythematosus ribosomal protein C37A2.8 C37A2.8 Protein of unknown function C37A5.1 C37A5.1 Member of the C. elegans putative membrane protein family 8, has a region of moderate similarity to a region of bestrophin (human VMD2), which plays a role in vision and causes Bests disease, adult vitelliform macular dystrophy, and bull's eye maculopathy Putative membrane protein C37A5.2 C37A5.2 Protein of unknown function, has very strong similarity to uncharacterized C. elegans C37A5.4 C37A5.4 C37A5.4 Protein of unknown function, has very strong similarity to uncharacterized C. elegans C37A5.2 C37A5.7 C37A5.7 Protein of unknown function, has weak similarity to C. elegans F46F11.8 C37A5.8 C37A5.8 Protein of unknown function, has weak similarity to C. elegans C37A5.2 C37A5.9 C37A5.9 Putative ortholog of C. elegans pry-1 gene product C37C3.1 C37C3.1 Protein with strong similarity to C. elegans T24A6.7 gene product C37C3.10 C37C3.10 Protein with moderate similarity to C. elegans F13B6.1 gene product C37C3.11 C37C3.11 Protein of unknown function C37C3.2 C37C3.2 Putative translation initiation factor 5, predicted ortholog S. cerevisiae Tif5p catalyzes hydrolysis of GTP on the 40S ribosomal subunit-initiation complex followed by joining to 60S ribosomal subunit C37C3.3 C37C3.3 Protein of unknown function, has high similarity to uncharacterized C. elegans C56C10.3 C37C3.4 grd-8;C37C3.4 Protein of unknown function, has moderate similarity to C. elegans GRD-6 grd-8 encodes a protein that contains a novel Ground domain. C37C3.6 C37C3.6 Protein containing an immunoglobulin (Ig) domain, 12 type 1 thrombospondin domains and 17 kunitz or bovine pancreatic trypsin inhibitor domains, has a region of low similarity to a region of C. elegans GON-1, which is a metalloprotease protease inhibitor; C37C3.6 encodes three isoforms of a large, novel multidomain glycoprotein orthologous to thrombospondin from Haemonchus contortus, papilin from D. melanogaster, and lacunin from Manduca sexta; the N-terminal region of C37C3.6 proteins have a domain set also found in the C-terminal region of ADAMTS matrix-associated metalloproteinases; C37C3.6 is generally required for normal cell arrangements, being required in embryos for viability and normal hypodermal enclosure, and in L1 larvae for normal excretory canal function. C37C3.7 C37C3.7 Member of the transthyretin-like family, has a region of low similarity to a region of tenascin C (hexabrachion, human TNC), which is a multidomain extracellular matrix glycoprotein that may be involved in cell adhesion and neurite outgrowth C37C3.8 C37C3.8 Protein containing a UPF0103 domain of unknown function, has high similarity to uncharacterized human LOC51072 C37C3.9 C37C3.9 Protein containing a BTB (BR-C, ttk and babor) or POZ (Pox virus and zinc finger) domain, which are found in some DNA and actin binding proteins and may mediate protein-protein interactions C37E2.1 C37E2.1 Member of the isocitrate dehydrogenase (NAD+) protein family isocitrate dehydrogenase; This gene encodes a protein predicted by Eisenberg and coworkers, with 52% accuracy, to be mitochondrial. C37E2.2 C37E2.2 Protein of unknown function, has high similarity to uncharacterized C. elegans C37E2.3 androgen-dependent expressed protein like C37E2.3 C37E2.3 Protein of unknown function, has high similarity to uncharacterized C. elegans C37E2.2 androgen-dependent expressed protein like C37E2.4 ceh-36;C37E2.4 Protein containing a homeobox domain (homeodomain), which are found in transcription factors, has moderate similarity to a region of cone-rod homeobox protein (rat Crx), which is a transcription factor that regulates pineal gland gene expression Homeobox domain; ceh-36 encodes a paired-like homeodomain transcription factor that is one of three orthodenticle (OTD)-like homeodomain proteins in C. elegans (the others being ttx-1 and ceh-37); CEH-36 is required broadly for specification of the AWC olfactory neuron and also for establishing the left-right asymmetry of the ASEL and ASER gustatory neurons; in addition, CEH-36 is sufficient to specify the AFD thermosensory neuron fate in some cell types; CEH-36 is expressed in the AWC and ASE chemosensory neurons. C37E2.5 ceh-37;C37E2.5 Homeodomain transcription factor, has similarity over the homeodomain to many human and D. melanogaster homeodomain transcription factors Homeobox domain; ceh-37 encodes one of three C. elegans proteins with an OTX-like homeodomain; however, CEH-37 lacks other domains found in OTX proteins, and the CEH-37 homeodomain is predicted to resemble the Myb domain of telomere-binding proteins; CEH-37 binds the telomeric sequence 'TTAGGC' if it is repeated at least 1.5 times, and is mainly localized to the telomere in vivo; ceh-37 mutants have a weak increase in chromosomal nondisjunction; CEH-37 is involved in specifying some aspects of the AWB olfactory neuron fate, such as expression of an AWB-specific odorant receptor and a LIM-class homeodomain protein, LIM-4; CEH-37 is expressed broadly in the early embryo, while in larvae and adults it is expressed solely in the excretory cell. C37F5.1 lin-1;C37F5.1 Putative transcription factor with an ETS-domain; involved in cell fate decisions in vulval development and elsewhere lin-1 encodes an Ets-domain-containing transcription factor that is a member of the ETS gene family that includes human ELK1, 3, and 4 (OMIM:600247); LIN-1 functions as a general effector of MAP kinase-mediated signaling; when MAP kinase is inactive, LIN-1 forms a complex with LIN-31/WH that inhibits vulval cell fate specification; upon MAP kinase activation (vulval induction), LIN-1 is phosphorylated, dissociates from LIN-31, and becomes inactive, thus allowing for vulval development. C37H5.1 C37H5.1 Member of the annexin protein family, which exhibit calcium-dependent phospholipid binding, has low similarity to annexin V (human ANXA5), which may be associated with antiphospholipid syndrome, preeclampsia, and systemic lupus erythematosus annexin; nex-4 encodes a predicted annexin. C37H5.10 C37H5.10 Protein of unknown function, has strong similarity to uncharacterized C. elegans C37H5.11 cwp-1 encodes a nematode-specific protein that is coexpressed with lov-1 and pkd-2. C37H5.11 C37H5.11 Protein of unknown function, has strong similarity to uncharacterized C. elegans C37H5.10 cwp-2 encodes a nematode-specific protein that is coexpressed with lov-1 and pkd-2. C37H5.12 C37H5.12 Protein of unknown function C37H5.13 C37H5.13 Member of the Acyl-CoA thioesterase family, which hydrolyze a range of acyl-CoA thioesters, has moderate similarity to peroxisomal acyl-CoA thioesterase 1 (human PTE1), which cleaves thioester bonds on medium chain acyl CoAs and binds HIV Nef protein C37H5.2 C37H5.2 Member of the alpha or beta hydrolase fold family, has weak similarity to S. cerevisiae Ict1p, which is required for normal sensitivity to copper C37H5.3 C37H5.3 Member of the alpha or beta hydrolase fold family, has weak similarity to S. cerevisiae Ecm18p, which may be involved in cell wall structure or biosynthesis C37H5.4 C37H5.4 Protein of unknown function cwp-3 encodes an unfamiliar protein predicted to be secreted and alleged to be coexpressed with polycystins; CWP-3 is dispensable for viability and gross morphology in mass RNAi screens. C37H5.5 C37H5.5 Protein of unknown function, has low similarity to uncharacterized S. pombe Spbc887.03cp C37H5.6 C37H5.6 Protein with high similarity to adenylosuccinate synthetase (human ADSS), which catalyzes the first committed step in the conversion of IMP to AMP in the purine biosynthesis pathway, member of the adenylosuccinate synthetase family adenylosuccinate synthetase C37H5.8 hsp-6;C37H5.8 Member of the heat shock HSP70 protein family heat shock 70 protein; hsp-6 encodes a mitochondrial-specific chaperone that is a member of the DnaK/Hsp70 superfamily of molecular chaperones; hsp-6 is believed to be involved in the mitochondrial unfolded protein response, as hsp-6 expression, normally broadly detected from the L1 larval through adult stages of development, is greatly increased in response to treatments that disrupt mitochondrial protein handling; loss of hsp-6 activity via RNAi results in severe growth defects with arrest at embryonic and early larval stages of development. C37H5.9 C37H5.9 Member of the astacin (M12A) family of metalloproteases, has a region of low similarity to a region of tolloid-like (mouse Tll), which processes probiglycan and appears to facilitate collagen-elastin crosslinking during extracellular matrix biogenesis C38C10.1 tkr-1;C38C10.1 Protein kinase of the TachyKinin Receptor family G protein coupled receptor; tkr-1 encodes a G protein-coupled receptor that is the C. elegans tachykinin-like neuropeptide receptor homolog; by homology, TKR-1 is predicted to function in modulation of excitatory neurotransmission; as loss of tkr-1 activity via RNAi results in moderate reduction of fat content, TKR-1 may play a specific role in regulating lipid metabolism; a tkr-1 reporter gene fusion is reportedly expressed in the socket cells of the deirid and post-deirid sensilla from the L2 larval stage through adulthood. C38C10.2 C38C10.2 Protein with similarity to human and D. melanogaster sodium-dependent inorganic phosphate cotransporters, member of the major facilitator superfamily Sodium/phosphate transporter; C38C10.2 is orthologous to the human gene SOLUTE CARRIER FAMILY 17 (ANION/SUGAR TRANSPORTER), MEMBER 5 (SLC17A5; OMIM:604322), which when mutated leads to disease. C38C10.3 C38C10.3 Protein with strong similarity to C. elegans ZC84.5 gene product C38C10.4 C38C10.4 Protein of unknown function, putative paralog of C. elegans F22B7.5 gpr-2 encodes a protein containing a GPR (G Protein Regulator)/GoLoco motif characteristic of guanine nucleotide exchange factors specific for G-alpha GTPases; GPR-2 appears to function redundantly during early embryogenesis and germ-line development to regulate chromosome and spindle movements during cell division; GPR-2 likely acts as a positive regulator of G protein signaling and specifically, may regulate GOA-1 signaling in the embryo; GPR-2 forms a protein complex with the nearly identical GPR-1 and with LIN-5, a coiled-coil protein that is required for proper localization of GPR-2 to the cell cortex and spindle asters of the early embryo; in addition, proper GPR-2/GPR-1/LIN-5 localization between the P2 and EMS blastomeres at the four-cell stage, which may contribute to spindle positioning in EMS, requires the MES-1/SRC-1 tyrosine kinase signaling pathway; GPR-2 is believed to act downstream of, or in parallel to, PAR-3, a PDZ domain-containing protein, in mitotic spindle positioning in the early embryo. C38C10.5 C38C10.5 Component of the Mediator complex required for transcriptional regulation of certain genes RGR1 (yeast) C38C3.1 C38C3.1 Protein containing a DUF215 domain of unknown function, has high similarity to uncharacterized C. elegans C38C3.2 7TM chemoreceptor, sru family C38C3.2 C38C3.2 Protein containing a DUF215 domain of unknown function, has high similarity to uncharacterized C. elegans C38C3.1 7TM chemoreceptor, sru family C38C3.3 C38C3.3 Protein of unknown function C38C3.4 C38C3.4 Protein containing three protein kinase domains protein kinase C38C3.5 unc-60;let-328;unc-60B;unc-66;C38C3.5 Actin binding protein that regulates the polymerization of actin; similar to mammalian cofilin and destrin actin depolymerizing factor; unc-60 encodes orthologs of actin depolymerizing factor/cofilin, actin-binding proteins that regulate actin filament dynamics; one UNC-60 isoform, UNC-60A, primarily binds G-actin, depolymerizes actin filaments, and inhibits actin polymerization; UNC-60A is essential during early embryonic development for polar body extrusion, cytokinesis, and embryonic patterning; UNC-60B, which does not inhibit actin polymerization, binds F- and G-actin and influences the rate of actin polymerization by the UNC-60B:actin ratio; UNC-60B is required for actin filament organization in body wall muscle, locomotion, and for efficient actin filament disassembly by UNC-78, an actin interactin protein 1 (AIP1) ortholog; UNC-60A and UNC-60B are differentially expressed: UNC-60A is found in oocytes, embryos, and the adult gonad and intestine, while UNC-60B is found in body wall muscle, the vulva, and spermatheca. C38C3.6 C38C3.6 Protein of unknown function C38C3.7 C38C3.7 Member of an uncharacterized protein family C38C3.8 C38C3.8 Putative ortholog of C. elegans Y69E1A.B gene product C38C3.9 C38C3.9 Protein containing nuclear hormone receptor C4-type zinc finger and ligand-binding domains, has low similarity to hepatocyte nuclear factor 4 gamma (mouse Hnf4g), which is involved in differential transcriptional regulation of HNF4-dependent genes zinc finger protein C38C5.1 C38C5.1 Protein of unknown function C38C6.2 C38C6.2 Protein containing one alpha amylase N-terminal catalytic domain, which degrade branched and unbranched starches, has weak similarity to neutral and basic amino acid transporter (mouse Slc3a1), which is a cystine and dibasic amino acid transporter Alpha amylase; atg-2 is orthologous to human SLC3A1 (OMIM:104614, mutated in cystinuria). C38C6.3 C38C6.3 Protein with moderate similarity to C. elegans B0457.2 gene product C38C6.4 C38C6.4 Member of the C. elegans Sre G protein-coupled chemoreceptor family, which are putative chemosensory receptors, has low similarity to uncharacterized C. elegans C42C1.1 7TM receptor, sre family C38C6.5 C38C6.5 Putative ortholog of C. elegans T08B6.5 gene product C38C6.6 C38C6.6 Protein of unknown function C38D4.2 C38D4.1;C38D4.2 Protein of unknown function, has very strong similarity to uncharacterized C. elegans W03G9.3 C38D4.3 C38D4.3 Protein containing an AT-hook motif, which bind DNA with a preference for A-T rich regions C38D4.4 C38D4.4 Putative ortholog of C. elegans F58G11.3 gene product C38D4.5 C38D4.5 Protein containing a WW domain, which bind proline-rich peptide epitopes, a pleckstrin homology (PH) domain, and a RhoGAP (GTPase activator protein) domain, has a region of low similarity to a region of breakpoint cluster region (human BCR) chimaerin C38D4.6 pal-1;ceh-3;nob-2;C38D4.6 Homeodomain transcription factor required for execution of various cell fates, has similarity to human and D. melanogaster caudal-type homeodomain transcription factors homeobox protein (cad subfamily); pal-1 encodes a homeodomain protein that is the C. elegans Caudal ortholog; PAL-1 is required maternally and embryonically for cell fate specification and posterior patterning during embryogenesis; PAL-1 is also required postembryonically for fate specification of the posterior V6 neuroectoblast during male tail development; PAL-1 is expressed in posterior blastomeres beginning at the four-cell stage of embryogenesis and its expression continues during embryogenesis in posterior-derived tissues and cells undergoing movement or forming midline structures; pal-1 is subject to both transcriptional and translational regulation. C38D4.7 C38D4.7 Protein of unknown function C38D4.8 arl-1;C38D4.8 Member of the ADP-ribosylation factor (ARF) family, which are GTP-binding proteins involved in protein trafficking, has moderate similarity to C. albicans Arf1p, which is an ADP-ribosylation factor ADP-ribosylation factor C38D4.9 C38D4.9 Protein with weak similarity to S. cerevisiae YIL064W methylase C38D9.1 C38D9.1 Protein containing a DUF38 domain of unknown function and an F-box domain, which serve as a link between a target protein and a ubiquitin-conjugating enzyme, has a region of low similarity to C. elegans FOG-2 This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins; this gene's encoded protein also contains an FTH/DUF38 motif, which may also mediate protein-protein interaction. C38D9.2 C38D9.2 Protein of unknown function, has high similarity to uncharacterized C. elegans F15D4.5 C38D9.3 C38D9.3 Protein of unknown function, has moderate similarity to uncharacterized C. elegans R09H3.1 C38D9.4 C38D9.4 Has strong similarity to several C. elegans proteins of unknown function C38D9.5 C38D9.5 Protein containing a WSN domain and an ankyrin repeat, which may mediate protein-protein interactions, has low similarity to C. elegans Y67A10A.3 C38D9.6 C38D9.6 Protein of unknown function, putative paralog of C. elegans F47H4.C This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins; this gene's encoded protein also contains an FTH/DUF38 motif, which may also mediate protein-protein interaction. C38D9.7 C38D9.7 Protein of unknown function, putative paralog of C. elegans C38D9.1 This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins; this gene's encoded protein also contains an FTH/DUF38 motif, which may also mediate protein-protein interaction. C38D9.8 C38D9.8 Protein of unknown function, putative paralog of C. elegans F31E9.4 This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins. C38D9.9 C38D9.9 Protein of unknown function, putative paralog of C. elegans F31E9.3 This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins; this gene's encoded protein also contains an FTH/DUF38 motif, which may also mediate protein-protein interaction. C38H2.1 C38H2.1 Protein containing TBC and RUN domains, which are regulators of small GTPases, has a region of low similarity to a region of S. cerevisiae Gyp7p, which is a GTPase-activating protein for Ypt7p Probable rabGAP domains C38H2.2 C38H2.2 Member of the Fringe-like family, which may be involved in controlling the response of the Notch receptor to specific ligands, has high similarity to uncharacterized human C1GALT1, which may be associated with Tn syndrome and IgA nephropathy C39B10.1 C39B10.1 Protein with weak similarity to C. elegans C26F1.6 G-protein coupled receptor C39B10.2 C39B10.2 Protein containing neurotransmitter-gated ion-channel ligand binding and transmembrane domains, has low similarity to rho 1 subunit of the gamma aminobutyric acid A (GABA) receptor (human GABRR1), which is involved in regulation of neuronal sensitivity gamma-aminobutyric-acid receptor C39B10.3 C39B10.3 Protein of unknown function, contains a coiled-coil region, has weak similarity to human p160ROCK (a Rho-associated, coiled-coil containing protein kinase 1) and human KIAA0373 protein C39B10.4 C39B10.4 Protein of unknown function C39B10.5 C39B10.5 Protein of unknown function C39B5.1 C39B5.1 Protein of unknown function, has strong similarity to C. elegans F56D6.5 7TM chemoreceptor, srz family C39B5.10 C39B5.10 Protein of unknown function C39B5.11 C39B5.11 Protein of unknown function, putative paralog of C. elegans Y39A3B.4 7TM chemoreceptor, srd family C39B5.12 C39B5.12 Protein of unknown function, putative paralog of C. elegans H04J21.2 7TM chemoreceptor, srd family C39B5.2 C39B5.2 Protein of unknown function, has moderate similarity to C. elegans C32B5.15 C39B5.3 C39B5.3 Protein of unknown function, has strong similarity to C. elegans T12B5.1 C39B5.4 C39B5.4 Protein of unknown function, has strong similarity to C. elegans ZC47.6 This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins; this gene's encoded protein also contains an FTH/DUF38 motif, which may also mediate protein-protein interaction. C39B5.5 C39B5.5 Protein of unknown function, putative paralog of C. elegans Y51H4A.D C39B5.6 C39B5.6 Protein with moderate similarity to D. melanogaster CG5463 (CG5463 gene product) amidotransferase C39B5.7 C39B5.7 Protein of unknown function, has strong similarity to C. elegans ZC47.4 This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins; this gene's encoded protein also contains an FTH/DUF38 motif, which may also mediate protein-protein interaction. C39B5.8 C39B5.8 Protein of unknown function, has strong similarity to C. elegans C17B7.11 This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins; this gene's encoded protein also contains an FTH/DUF38 motif, which may also mediate protein-protein interaction. C39B5.9 C39B5.9 Protein of unknown function, putative paralog of C. elegans F52D2.8 This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins; this gene's encoded protein also contains an FTH/DUF38 motif, which may also mediate protein-protein interaction. C39D10.1 C39D10.1 Protein of unknown function C39D10.2 C39D10.2 Protein of unknown function C39D10.3 C39D10.3 Protein with similarity to human PCYT2, phosphoethanolamine cytidylyltransferase B. subtilis glycerol-3-phosphate cytidylyltransferase C39D10.5 C39D10.5 Protein of unknown function C39D10.6 C39D10.6 Protein of unknown function, has weak similarity to C. elegans F17H10.2 C39D10.7 C39D10.7 Protein containing 20 chitin binding peritrophin-A domains, has a region of low similarity to C. elegans CEJ-1, which is involved in embryogenesis and morphogenesis similar to C. elegans proteins B0280.5, R02F2.4 and C07G2.1 C39D10.8 C39D10.8 Protein with weak similarity to C. elegans Y105C5B.5 gene product C39E6.1 lon-2;C39E6.1 Protein required for embryonic viability C39E6.2 C39E6.2 Protein of unknown function C39E6.3 C39E6.3 Protein containing a homeobox domain (homeodomain), which are found in transcription factors, has a region of high similarity to a region of H6 homeo box 3 (mouse Hmx3), which is a DNA binding protein required for inner ear vestibular system formation C39E6.4 C39E6.4 Protein of unknown function C39E6.6 npr-1;C39E6.6 G protein-coupled receptor with similarity to H. sapiens and D. melanogaster neuropeptide Y receptors G-protein coupled receptor; npr-1 encodes a predicted G protein-coupled neuropeptide receptor that is homologous to the mammalian neuropeptide Y (NPY) receptor (OMIM:162641) required for regulating anxiety, food consumption, and pain sensation; in C. elegans, NPR-1 is involved in ethological variations of social behavior such as social versus solitary feeding; NPR-1 also affects some aspect of UNC-6/netrin-mediated branching of motor neurons, as strong npr-1 mutations can suppress abnormal migration of ventral nerve cord neurons induced by overexpression of UNC-6 lacking domain C; NPR-1 is expressed predominantly in the nervous system, and particularly in the AQR, PQR, and URX neurons that are exposed to the body fluid. C39E9.1 C39E9.1 Protein of unknown function, has high similarity to uncharacterized C. elegans F49E11.11 testis-specific protein TPX-1 like C39E9.10 C39E9.10 Member of the sugar (and other) transporter family, has high similarity to uncharacterized C. elegans F09A5.1 tetracycline resistance protein like C39E9.11 C39E9.11 Protein containing an N-terminal coiled-coil region, has similarity over C-terminal half to human TPRC (protein involved in a papillary renal cell carcinoma associated translocation) C39E9.11 is orthologous to the human gene PAPILLARY RENAL CELL CARCINOMA (TRANSLOCATION-ASSOCIATED) (PRCC; OMIM:179755), which when mutated leads to disease. C39E9.12 C39E9.12 Protein containing a SAP domain, which may bind DNA C39E9.13 C39E9.13 Putative subunit of replication factor C Human activator 1 38 KD subunit like C39E9.14 dli-1;C39E9.14 Protein of unknown function, has low similarity to a region of cytoplasmic dynein light intermediate chain 1 (rat Lic1), which mediates interaction of pericentrin (mouse Pcnt) with dynein and may act in dynein-mediated intracellular transport and mitosis C39E9.2 C39E9.2 Member of the SCP-like extracellular protein family, has low similarity to a region of acidic epididymal glycoprotein (rat Aeg), which plays a role in sperm-egg fusion and may play a role in sperm development testis-specific protein TPX-1 like C39E9.3 C39E9.3 Protein containing two collagen triple helix repeats, which are found in some extracellular proteins, and a nematode cuticle collagen N-terminal domain, has a region of high similarity to a region of C. elegans SQT-1 collagen C39E9.4 C39E9.4 Member of the SCP-like extracellular protein family, has high similarity to uncharacterized C. elegans F49E11.11 testis-specific protein TPX-1 like C39E9.5 C39E9.5 Member of the SCP-like extracellular protein family, has low similarity to a region of acidic epididymal glycoprotein (rat Aeg), which plays a role in sperm-egg fusion and may play a role in sperm development testis-specific protein TPX-1 like C39E9.6 C39E9.6 Member of the SCP-like extracellular protein family, has high similarity to uncharacterized C. elegans C39E9.5 testis-specific protein TPX-1 like C39E9.7 C39E9.7 Protein of unknown function, has weak similarity to uncharacterized C. elegans C18D1.2 sodium/phosphate transporter C39E9.8 C39E9.8 Protein of unknown function, has low similarity to uncharacterized C. elegans Y105C5.G C39E9.9 C39E9.9 Protein containing two collagen triple helix repeats, which are found in some extracellular proteins, and a nematode cuticle collagen N-terminal domain, has moderate similarity to a region of C. elegans BLI-1 collagen C39F7.1 C39F7.1 Protein of unknown function C39F7.4 C39F7.4 Protein with strong similarity to human RAB1, which is a Ras-related GTP-binding protein involved in vesicle transport, member of the Ras superfamily of GTP binding proteins RAS-related protein; rab-1 encodes an ortholog of the small Ras-like GTPase Rab1; by homology, RAB-1 is predicted to play a role in intracellular vesicle trafficking, and consistent with this broad role, large-scale RNAi screens indicate that rab-1 activity is required for fertility, movement, and survival; in yeast two-hybrid assays, RAB-1 interacts with TIR-1, a C. elegans SARM ortholog that is required for innate immunity; RNAi studies suggest that RAB-1 and TIR-1 likely function in a pathway that controls expression of antimicrobial peptides such as NLP-29 and NLP-31; rab-1 also appears to play a role in regulating polyglutamine protein aggregation, as rab-1(RNAi) animals show premature accumulation of protein aggregates; in situ hybridization studies indicate that rab-1 is broadly expressed, with elevated levels apparent in the germline. C39F7.5 C39F7.5 Protein of unknown function, has a region of weak similarity to human FLJ10648, which is a nuclear protein that stimulates cell proliferation C39H7.1 C39H7.1 Protein containing a protein kinase domain, has low similarity to S. pombe Hhp1p, which is a putative casein kinase I (CKI) required for DNA repair casein kinase C39H7.4 C39H7.4 Protein of unknown function C39H7.5 C39H7.5 Protein of unknown function, has low similarity to uncharacterized C. elegans F40D4.5 7TM chemoreceptor, srsx family C39H7.6 C39H7.6 Protein of unknown function, has high similarity to uncharacterized C. elegans C39H7.7 7TM chemoreceptor, srd family C39H7.7 C39H7.7 Putative ortholog of C. elegans B0547.3 gene product 7TM chemoreceptor, srd family C40A11.1 C40A11.1 Protein containing three meprin and TRAF homology (MATH) domains, has high similarity to uncharacterized C. elegans C46F9.3 C40A11.10 C40A11.10 Protein of unknown function C40A11.2 C40A11.2 Protein containing a K+ channel tetramerization domain, which facilitate assembly of alpha-subunits into functional tetrameric channels, has moderate similarity to uncharacterized C. elegans F22E5.6 C40A11.3 C40A11.3 Protein containing a K+ channel tetramerization domain, which facilitate assembly of alpha-subunits into functional tetrameric channels, has a region of high similarity to a region of NY-REN-45 tumor antigen (human LOC51133) C40A11.4 C40A11.4 Protein containing a K+ channel tetramerization domain, which facilitate assembly of alpha-subunits into functional tetrameric channels, has moderate similarity to uncharacterized C. elegans C40A11.2 C40A11.5 C40A11.5 Member of the protein-tyrosine phosphatase family, which are involved in control of cell growth, proliferation, differentiation and transformation, has weak similarity to a region of mouse Ptpn1, which is a non-receptor type protein tyrosine phosphatase protein-tyrosine phosphatase C40A11.6 C40A11.6 Protein containing a K+ channel tetramerization domain, which facilitate assembly of alpha-subunits into functional tetrameric channels, has high similarity to uncharacterized C. elegans C40A11.7 C40A11.7 C40A11.7 Protein containing a K+ channel tetramerization domain, which facilitate assembly of alpha-subunits into functional tetrameric channels, has high similarity to uncharacterized C. elegans C40A11.6 C40A11.8 C40A11.8 Protein with strong similarity to C. elegans F36H5.4 gene product C40A11.9 C40A11.9 Putative ortholog of C. elegans Y43F4A.2 gene product C40C9.1 twk-4;C40C9.1 Member of the 4 TM potassium channel protein family potassium channel protein C40C9.2 acr-9;C40C9.2 Protein with high similarity to C. elegans ACR-16, which is a nicotinic acetylcholine receptor alpha-1 subunit, contains neurotransmitter-gated ion-channel ligand binding and transmembrane domains acetylcholine receptor; acr-9 encodes a predicted member of the alpha subunit family of nicotinic acetylcholine receptors. C40C9.3 C40C9.3 Protein of unknown function, has low similarity to uncharacterized C. elegans Y57G11B.5 C40C9.4 C40C9.4 Protein of unknown function C40C9.5 C40C9.5 Member of the carboxylesterase type B family, has low similarity to neuroligin I (rat Nlgn1), which is a neuronal cell surface protein and a calcium-dependent cell adhesion molecule that acts as a ligand for the cell surface receptor beta-neurexin Carboxylesterases (2 domains) C40D2.1 C40D2.1 Protein containing two meprin and TRAF homology (MATH) domains, has high similarity to uncharacterized C. elegans C46F9.1 C40D2.2 C40D2.2 Protein containing three meprin and TRAF homology (MATH) domains, has strong similarity to uncharacterized C. elegans ZK250.8 possible trans-splice site at 5004; The C40D2.2 gene encodes a protein closely similar to C46F9.3, which has a meprin-associated Traf homology (MATH) domain and may be involved in apoptosis. C40D2.3 C40D2.3 Protein containing three meprin and TRAF homology (MATH) domains, has high similarity to uncharacterized C. elegans C46F9.3 C40D2.4 C40D2.4 Protein containing a HOX homeodomain, has similarity over homeodomains to D. melanogaster transcription factor EYG (eyegone) C40H1.1 cpb-1;C40H1.1 Member of the RNA recognition motif protein family, required for spermatogenesis Ovarian protein (fly); The cbp-1 gene encodes a cytoplasmic polyadenylation element binding (CPEB) protein homolog involved in two steps of spermatogenesis. C40H1.2 C40H1.2 Member of the lipase class 3 family, which are a subset of lipolytic enzymes that hydrolyze ester linkages of triglycerides, has low similarity to uncharacterized C. elegans Y49E10.R C40H1.3 C40H1.3 Protein of unknown function, has weak similarity to C. elegans F28C6.9 C40H1.4 C40H1.4 Member of the GNS1 or SUR4 family of integral membrane proteins, has low similarity to polyunsaturated fatty acid (PUFA) elongase (C. elegans CEEl01), which contains the condensation activity required for fatty acid elongation Yeast hypothetical YCR34W; The elo-4 gene encodes a paralog of elo-1 and elo-2, each of which encodes a polyunsaturated fatty acid (PUFA) elongase; its function in vivo is unknown. C40H1.5 C40H1.5 Member of the transthyretin-like family, has high similarity to uncharacterized C. elegans T28B4.3 Transthyretin-like family C40H1.6 C40H1.6 Protein of unknown function, has high similarity to uncharacterized human HSPC155 C40H1.7 C40H1.7 Putative ortholog of C. elegans Y49E10.P gene product C40H5.1 C40H5.1 Protein of unknown function, has strong similarity to uncharacterized C. elegans ZC412.7 C40H5.2 C40H5.2 Protein of unknown function C40H5.3 C40H5.3 Putative ortholog of C. elegans D1053.4 gene product C40H5.4 C40H5.4 Protein of unknown function, has low similarity to uncharacterized C. elegans Y45F10D.11 B.subtilis penicillin-binding protein like C40H5.5 ttx-3;C40H5.5 LIM homeodomain transcription factor required late in the differentiation of the AIY interneuron so the interneuron can function in thermosensation; has similarity to LIM homeodomain transcription factors of human and D. melanogaster LIM domain containing proteins (2 domains), homeobox protein (lim subfamily); The ttx-3 gene encodes a LIM homeodomain protein required for function of the thermosensory interneuron AIY. C40H5.6 C40H5.6 Protein of unknown function, has a region of high similarity to C. elegans C18E3.2, which is involved in histogenesis and organogenesis C40H5.7 C40H5.7 Protein with weak similarity to C. elegans mec-9 (protein with EGF-like repeats that is required for touch sensation) EGF-domain protein C41A3.1 C41A3.1 Member of the beta-keto-acyl-ACP synthase (tentative) protein family polyketide synthase; This gene encodes a protein predicted by Eisenberg and coworkers, with 68% accuracy, to be mitochondrial. C41A3.2 C41A3.2 Protein of unknown function C41C4.1 C41C4.1 Protein of unknown function, has low similarity to uncharacterized C. elegans F36D1.8 C41C4.2 sre-2;C41C4.2 Putative G protein-coupled receptor, member of the SRE subfamily of receptors which are expressed in chemosensory neurons, has similarity in the N-terminus to rat and S. cerevisiae tricarboxylate carriers 7TM receptor, sre family C41C4.3 C41C4.3 Protein containing three leucine rich repeats, which mediate protein-protein interactions Leucine Rich Repeat (2 copies) (2 domains) C41C4.4 ire-1;ire1;C41C4.4 Serine/threonine protein kinase and endoribonuclease; putative ortholog of the H. sapiens ERN1/IRE1 and S. cerevisiae Ire1p proteins, which are involved in signaling the unfolded protein response from the endoplasmic reticulum to the nucleus serine/threonine kinase; ire-1 encodes a transmembrane serine/threonine protein kinase and site-specific endoribonuclease orthologous to Saccharomyces cerevisiae inositol-requiring 1 protein kinase (Ire1) and human endoplasmic reticulum-to-nucleus signaling 1 (ERN1, OMIM:604033); IRE-1 is required for the unfolded protein response (UPR) that counteracts cellular stress induced by accumulation of unfolded proteins in the endoplasmic reticulum (ER); in response to ER stress, IRE-1 cleaves xbp-1 mRNA to produce transcriptionally active XBP-1 that positively regulates UPR gene expression in order to maintain ER homeostasis. C41C4.5 unc-105;C41C4.5 Member of the amiloride-sensitive sodium channel family, the degenerin family and DEG/ENaC superfamily of proteins Amiloride-sensitive sodium channel; unc-105 encodes a muscle degenerin, a mechanosensory membrane channel that is a member of the degenerin ion channel superfamily and similar to subunits of the mammalian amiloride-sensitive epithelial sodium channel (ENaC, OMIM:600761); UNC-105 is required for normal growth and for normal contraction and organization of muscle, where it is expressed; UNC-105 interacts with LET-2, an alpha2 chain of type IV collagen that is also expressed by muscle and localized to the basement membrane between muscle and hypodermis. C41C4.6 C41C4.6 Protein containing a ubiquitin-like protein-specific protease (Ulp1) family C-terminal catalytic domain, which may bind other protein domains C41C4.7 C41C4.7 Protein of unknown function, has a region of high similarity to a region of cystinosin (human CTNS), which is a lysosomal membrane protein that may be involved in the lysosomal transport of cystine C41C4.7 encodes an ortholog of the human cystinosin gene (CTNS; OMIM:606272, which when mutated leads to nephropathic cystinosis (OMIM:219800); sequence analysis suggests that cystinosin is an integral lysosomal membrane protein. C41C4.8 C41C4.8 Member of the ATPases associated with various cellular activities (AAA) family P97 protein C41D11.1 C41D11.1 Protein of unknown function C41D11.2 C41D11.2 Putative translation initiation factor, protein with strong similarity to human EIF3S3, translation initiation factor eIF3 p40 subunit C41D11.3 C41D11.3 Putative ortholog of C. elegans C41D11.4 gene product C41D11.4 C41D11.4 Putative ortholog of C. elegans C41D11.3 gene product C41D11.5 C41D11.5 Putative mitochondrial endonuclease, predicted S. cerevisiae ortholog Nuc1p has both DNAase and RNase activity C41D11.6 C41D11.6 Protein with strong similarity to C. elegans K08D10.5 gene product C41D11.7 C41D11.7 Member of the DEAD or DEAH box ATP-dependent RNA helicase family, has low similarity to S. cerevisiae Hcs1p, which is DNA helicase A and a Dom34p-interacting protein DNA-binding protein C41D11.8 cps-6;C41D11.8 Mitochondrial Endonuclease G involved in DNA degradation during apoptosis C41D11.9 C41D11.9 Protein with moderate similarity to C. elegans C02F5.3 gene product C41D7.1 C41D7.1 Protein of unknown function C41D7.2 ptr-3;C41D7.2 Member of an uncharacterized protein family ptr-3 encodes a member of the Patched superfamily. C41G11.1 C41G11.1 Protein of unknown function C41G11.2 C41G11.2 Protein of unknown function C41G11.3 rgs-6;C41G11.3 Protein containing a regulator of G protein signaling domain, has low similarity to a region of regulator of G protein signaling 12 (human RGS12), which binds to G protein alpha i subunits and stimulates their intrinsic GTPase activity rgs-6 encodes a regulator of G protein signaling; by homology, RGS-6 is predicted to function as a GTPase-activating protein that binds G protein alpha subunits and negatively regulates heterotrimeric G protein signaling; loss of rgs-6 activity via RNAi or a deletion mutation results in no obvious defects, and likewise, rgs-6 overexpression has no measurable effect on egg-laying behavior, locomotion, or viability; the rgs-6 expression pattern has not yet been reported. C41G11.4 C41G11.4 Protein with moderate similarity to C. elegans H22D07.1 gene product G-protein coupled receptor C41G6.1 C41G6.1 Member of the cytochrome P450 family, has low similarity to cytochrome P450 subfamily IIC (mephenytoin 4-hydroxylase) polypeptide 8 (human CYP2C8), which is a monooxygenase that metabolizes steroids, fatty acids, and xenobiotics cytochrome P450 C41G6.10 C41G6.10 Member of the 7-transmembrane chemoreceptor family of G protein-coupled receptors (GPCR), has high similarity to uncharacterized C. elegans C41G6.14 7TM chemoreceptor, sri family C41G6.11 C41G6.11 Member of the 7-transmembrane chemoreceptor family of G protein-coupled receptors (GPCR), has high similarity to uncharacterized C. elegans C41G6.10 7TM chemoreceptor, sri family C41G6.12 C41G6.12 Protein of unknown function, has very strong similarity to uncharacterized C. elegans Y75B12B.9 C41G6.13 C41G6.13 Protein of unknown function, has very strong similarity to uncharacterized C. elegans Y75B12B.8 C41G6.14 C41G6.14 Protein of unknown function, putative paralog of C. elegans C41G6.10 7TM chemoreceptor, sri family C41G6.15 C41G6.15 Protein of unknown function, putative paralog of C. elegans C41G6.3 7TM chemoreceptor, srw family C41G6.2 C41G6.2 Protein with strong similarity to C. elegans C41G6.3 gene product 7TM chemoreceptor, srw family C41G6.3 C41G6.3 Protein of unknown function, has high similarity to uncharacterized C. elegans C41G6.8 7TM chemoreceptor, srw family C41G6.5 C41G6.5 Protein containing a nuclear hormone receptor C4-type zinc finger domain, has a region of moderate similarity to a region of estrogen-related receptor gamma (mouse Esrrg), which binds to DNA at estrogen response elements and activates transcription Zinc finger, C4 type (two domains) C41G6.6 C41G6.6 Member of an uncharacterized protein family C41G6.7 C41G6.7 Protein of unknown function, has moderate similarity to uncharacterized C. elegans T10H4.6 7TM chemoreceptor, srw family C41G6.8 C41G6.8 Protein of unknown function, has high similarity to uncharacterized C. elegans C41G6.3 7TM chemoreceptor, srw family C41G6.9 C41G6.9 Member of the 7-transmembrane chemoreceptor family of G protein-coupled receptors (GPCR), has moderate similarity to uncharacterized C. elegans Y60A3A.3 C41G7.1 CeSMN;C41G7.1;SMN Ortholog of human SMN, survival motor neuron, a gene associated with spinal muscular atrophy in humans Human muscular atrophy protein like; smn-1 encodes a homolog of human SMN, which when mutated leads to spinal muscular atrophy (OMIM:253300). C41G7.2 klp-16;CeKLP-16;C41G7.2 C-terminal motor kinesin that is required for appropriate spindle assembly in the germ line and likely functions in chromosome movement during early development kinesin, kinesin-14 family; klp-16 encodes a C-terminal motor kinesin orthologous to the Drosophila melanogaster Ncd and Saccharomyces cerevisiae Kar3; however KLP-16 along with KLP-3, KLP-15 and KLP-17 form an unique subgroup based on amino acid sequence and secondary structure analysis; klp-16 is involved in development of the nervous system in embryos and in chromosome segregation; in situ RNA hybridization experiments indicate that klp-16 is localized in the anterior nervous system in the head region of late embryos. C41G7.3 C41G7.3 Member of the tryptophan-rich sensory protein (TspO) and mitochondrial peripheral benzodiazepine receptor (MBR) family, has a region of low similarity to peripheral-type benzodiazepine receptor (mouse Bzrp), which binds benzodiazepines and isoquinolines C41G7.4 C41G7.4 Protein containing a SET domain, which are involved in protein-protein interactions, has a region of low similarity to a region of S. pombe Clr4p, which is a protein required for mating-type locus and centromeric silencing Drosophila SU(VAR)3-9 protein like C41G7.5 ahr-1;C41G7.5 Putative aryl-hydrocarbon receptor; member of the basic helix-loop-helix DNA-binding domain family aryl hydrocarbon (AH) receptor; ahr-1 encodes an aryl hydrocarbon receptor (ligand-activated basic helix-loop-helix transcription factor) ortholog that biochemically resembles its vertebrate relatives (OMIM:600253) which mediate the carcinogenic and teratogenic effects of environmental toxins; AHR-1 binds HSP90 tightly, and forms a dimer with AHA-1 that binds DNA fragments containing the mammalian xenobiotic response element; AHR-1 is expressed in neurons, and may play a role in neuronal migration. C41G7.6 C41G7.6 Protein with weak similarity to C. elegans Y113G7B.12 gene product C41G7.7 C41G7.7 Protein of unknown function C41H7.1 C41H7.1 Protein of unknown function C41H7.2 C41H7.2 Protein containing an F-box domain, which serve as a link between a target protein and a ubiquitin-conjugating enzyme This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins; its encoded protein also contains a Pfam-B45 motif of presently unknown function. C41H7.3 C41H7.3 Protein of unknown function, has moderate similarity to uncharacterized C. elegans C41H7.6 C41H7.4 C41H7.4 Protein of unknown function, has high similarity to uncharacterized C. elegans C41H7.5 C41H7.5 C41H7.5 Protein of unknown function, has high similarity to uncharacterized C. elegans C41H7.6 C41H7.6 C41H7.6 Protein of unknown function, has high similarity to uncharacterized C. elegans C41H7.5 C41H7.7 C41H7.7 Member of the C-type lectin protein family C42C1.1 C42C1.1 Member of the C. elegans Sre G protein-coupled chemoreceptor family, which are putative chemosensory receptors, has low similarity to uncharacterized C. elegans Y39C12A.6 7TM chemoreceptor, sre family C42C1.10 C42C1.10 Member of the mitochondrial carrier protein family of membrane transporters, has moderate similarity to human SLC25A19, which is a nucleotide transporter mitochondrial carrier protein; This gene encodes a protein predicted by Eisenberg and coworkers, with 52% accuracy, to be mitochondrial. C42C1.11 AP-1;C42C1.11 Arginine aminopeptidase of the M1 family of metalloexopeptidases peptidase C42C1.12 C42C1.12 Protein of unknown function C42C1.13 C42C1.13 Protein of unknown function C42C1.14 C42C1.14 Protein of unknown function rpl-34 encodes a large ribosomal subunit L34 protein that affects growth and body coloration. C42C1.15 C42C1.15 Protein of unknown function C42C1.16 C42C1.16 Putative ortholog of C. elegans F47B8.10 gene product C42C1.2 C42C1.2 Member of the protein phosphatase 2C family, which are Mg2+ dependent protein serine and threonine phosphatases, has low similarity to uncharacterized human KIAA1157 protein phosphatase C42C1.3 C42C1.3 Protein of unknown function C42C1.4 C42C1.4 Protein of unknown function, has weak similarity to uncharacterized human KIAA0804 C42C1.5 C42C1.5 Protein with high similarity to mannose-1-phosphate guanylyltransferase (S. cerevisiae Psa1p), which is a GDP-mannose pyrophosphorylase, member of the nucleotidyl transferase family, contains four bacterial transferase hexapeptide (four repeats) domains guanyltransferase C42C1.6 C42C1.6 Protein of unknown function C42C1.7 C42C1.7 Putative G protein-coupled receptor, member of a subfamily with distant similarity to members of the SRG subfamily, no homolog found in human or D. melanogaster C42C1.8 C42C1.8 Putative paralog of C. elegans B0416.5 gene product C42C1.9 C42C1.9 Protein with strong N-terminal similarity to human Hs.125849 and Hs.196610 gene products C42D4.1 C42D4.1 Protein of unknown function, has weak similarity to C. elegans C32H11.6 C42D4.11 C42D4.11 Protein containing a C-type lectin domain, which mediate calcium-dependent carbohydrate recognition, has high similarity to uncharacterized C. elegans Y116A8A.8 C42D4.13 C42D4.13 Protein of unknown function C42D4.2 C42D4.2 Member of the carboxylesterase type B family, has a region of low similarity to esterase 2 (rat Es2), which catalyzes hydrolysis of a variety of carboxylic esters including the anti-cholesteraemic agent clofibrate and may have a role in lipid metabolism esterase C42D4.3 C42D4.3 Protein containing a DB module domain, has high similarity to uncharacterized C. elegans F35B3.4 C42D4.4 C42D4.4 Member of the 7-transmembrane chemoreceptor family of G protein-coupled receptors (GPCR), has weak similarity to C. elegans ODR-10, which is involved in odorant response 7TM chemoreceptor, str family C42D4.5 str-1;C42D4.5 Member of the 7-transmembrane chemoreceptor family of G protein-coupled receptors (GPCR), has low similarity to C. elegans ODR-10, which is involved in odorant response 7TM chemoreceptor, str family C42D4.6 C42D4.6 Member of the Skp1 family, which are needed for targeted protein degradation during the cell cycle, has a region of low similarity to a region of S. cerevisiae Skp1p, which is a component of Cbf3 kinetochore complex and SCF (Skp1p-cullin-F-box) complexes The skr-16 gene encodes a homolog of Skp1 in S. cerevisiae that has no known function in vivo, since skr-16(RNAi) animals are at least superficially normal. C42D4.8 rpc-1;C42D4.8 Member of the RNA polymerase protein family DNA-directed RNA polymerase II largest subunit C42D4.9 str-220;C42D4.9 Member of the 7-transmembrane chemoreceptor family of G protein-coupled receptors (GPCR), has moderate similarity to uncharacterized C. elegans C07G3.3 7TM chemoreceptor, str family C42D8.1 C42D8.1 Protein of unknown function C42D8.2 vit-2;yp170B;C42D8.2 170 kDa yolk protein vitellogenin; The vit-2 gene encodes the vitellogenin homolog YP170. C42D8.3 uvt-3;C42D8.3 Protein of unknown function, has a region of moderate similarity to a region of S. cerevisiae Ydr531p, which is a putative pantothenate kinase involved in coenzyme A biosynthesis C42D8.4 C42D8.4 Protein containing an ETS domain, which bind promoter DNA, has a region of strong similarity to a region of pet-1 transcription factor (rat Rn.9775), which may function in the differentiation and maintenance of serotonergic neurons DNA-binding protein C42D8.5 C42D8.5 Putative angiotensin converting enzyme, putative ortholog of H. sapiens DCP1 gene product [dipeptidyl carboxypeptidase 1 (angiotensin I converting enzyme) (GenBank)] peptidase; acn-1 encodes an ACE-like protein required for larval development and adult morphogenesis, and probably for cell fusion in larval seam cells; ACN-1 lacks not only the HExxH consensus metallopeptidase motif, but also other active site residues found in the sequence HEAI/VxD of mammalian and insect ACEs; acn-1 is expressed in hypodermal cells, vulval precursor cells, and ray papillae in the male tail; the hypodermal expression of acn-1 appears to be controlled by nhr-23 and nhr-25. C42D8.8 uvt-4;apl-1;C42D8.8 Protein containing an amyloid A4 extracellular domain, which is found in Alzheimer's disease-associated APP protein, has low similarity to amyloid beta precursor protein (mouse App), which is a cell surface protease inhibitor that reduces copper apl-1 is orthologous to human AMYLOID BETA A4 PRECURSOR PROTEIN (APP; OMIM:104760), which when mutated leads to familial Alzheimer disease or cerebroarterial amyloidosis; APL-1 contains a copper-binding domain and is required for progession past the L1 larval stage, presumably because it is also required for pharyngeal pumping; apl-1 genetically interacts with feh-1 to affect pharyngeal pumping, and interacts with the PTB2 domain of FEH-1 in vitro. C43C3.1 C43C3.1;ife-1 Protein containing an intermediate filament tail domain intermediate filament protein; ifp-1 encodes a nonessential intermediate filament protein; IFP-1 is predicted to function as a structural component of the cytoskeleton; IFP-1 has no obvious function in RNAi assays. C43C3.2 C43C3.2 Member of the rhodopsin family of G protein-coupled receptors (GPCR), has low similarity to somatostatin receptor 5 (rat Sstr5), which inhibits adenylyl cyclase and mediates inhibitory effects of somatostatin (rat Sst) on cell proliferation and secretion G protein coupled receptor C43C3.3 C43C3.3 Protein containing a zona pellucida domain, which may be a receptor-like glycoprotein dyf-8 encodes a protein predicted to form a cell-surface ligand with a zona pellucida domain; DYF-8 is required for permeability of amphid and phasmid neurons to external dyes, chemotaxis to ammonium chloride, avoidance of high osmotic stimuli, male mating, and dauer formation. C43D7.2 C43D7.2 Protein containing an F-box domain, which serve as a link between a target protein and a ubiquitin-conjugating enzyme, has high similarity to uncharacterized C. elegans F55C9.9 This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins. C43D7.4 C43D7.4 Protein of unknown function, has high similarity to uncharacterized C. elegans C43D7.5 C43D7.5 C43D7.5 Protein of unknown function, has high similarity to uncharacterized C. elegans C43D7.4 C43D7.6 C43D7.6 Protein of unknown function, putative paralog of C. elegans Y116F11.J This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins. C43D7.7 C43D7.7 Protein of unknown function C43D7.8 C43D7.8 Protein of unknown function, has strong similarity to C. elegans Y116F11.I This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins. C43E11.1 C43E11.1 Protein containing a SAP domain, which may bind DNA, and an RNA recognition motif (RRM, RBD, or RNP), has low similarity to a region of apoptotic chromatin condensation inducer in nucleus (mouse Acinus), which induces apoptotic chromatin condensation C43E11.10 C43E11.10 Protein containing an AT-hook motif, which bind DNA with a preference for A-T rich regions, has low similarity to cell division cycle 6 (human CDC6), which is involved in DNA replication initiation cdc-6 encodes a homolog of an origin complex component (CDC6) which in yeast controls the start of DNA replication, and also has a distant paralog (Y39A1A.12) within the C. elegans genome; CDC-6 is superficially dispensable for embryonic viability, perhaps because of redundancy with Y39A1A.12. C43E11.11 C43E11.11 Protein with weak similarity to Golgi transport complex 90 kDa (human GOLTC1), which is a subunit of the Golgi transport complex that is associated with the Golgi and stimulates intra-Golgi transport C43E11.2 C43E11.2 Protein containing an ERCC4 domain, which may modify DNA, has a region of low similarity to a region of S. pombe Mus81p, which is a holliday junction resolvase subunit that associates with S. pombe Eme1p C43E11.3 C43E11.3 Protein containing a SET domain, which are involved in protein-protein interactions, and a WW domain, has a region of low similarity to a region of huntingtin interacting protein B (human HYPB), which binds normal and mutant Huntingtin protein C43E11.3 is orthologous to human NUCLEAR RECEPTOR-BINDING Su-var, ENHANCER OF ZESTE, AND TRITHORAX DOMAIN PROTEIN 1 (NSD1; OMIM:606681), which when mutated leads to sporadic Sotos syndrome (OMIM:117550). C43E11.4 C43E11.4 Protein containing an elongation factor Tu GTP binding domain, an elongation factor Tu domain 2, and an elongation factor Tu C-terminal domain, has moderate similarity to mitochondrial translation elongation factor Tu (S. cerevisiae Tuf1p) elongation factor Tu C43E11.5 C43E11.5 Member of the protein-tyrosine phosphatase family, which are involved in control of cell growth, proliferation, differentiation and transformation, has very strong similarity to uncharacterized C. elegans C50F2.5 C43E11.6 C43E11.6 Protein containing three PDZ, DHR, or GLGF domains and three SAM (sterile alpha motif) domains, has low similarity to a region of neural tissue-specific F-actin binding protein (neurabin, rat LOC84685), which cross-links actin filaments nab-1 encodes a PDZ and SAM domain-containing protein that is the sole C. elegans ortholog of the mammalian Neurabin/Spinophilin proteins; by homology, NAB-1 is predicted to interact with F-actin, ZYG-8/Doublecortin and the SAD-1 serine/threonine kinase to regulate interactions between the actin and microtubule networks during cell migration, growth cone guidance, and cell division; loss of nab-1 activity via RNAi has been reported to result in early embryonic lethality, dumpy and left-handed roller animals, as well as abnormalities in germ-line development and vulval morphogenesis; in large-scale screens, nab-1 RNAi did not result in any obvious abnormalities; NAB-1 translational reporter fusions show expression in hypodermal cells, neurons, and muscle. C43E11.7 C43E11.7 Protein containing a mutT domain ndx-7 encodes a NUDIX hydrolase; by sequence comparison, NDX-7 is predicted to function as a pyrophosphatase, and is most closely related to the mouse RP2 protein that has unknown substrate specificity but is regulated transcriptionally by the presence of androgens; in C. elegans, loss of ndx-7 activity via RNA-mediated interference (RNAi) does not result in any obvious abnormalities, consistent with the proposed nonessential roles for Nudix proteins in eliminating potentially toxic nucleotide metabolites from cells and modulating levels of metabolic intermediates by shuttling them into alternative biochemical pathways. C43E11.8 C43E11.8 Member of the Exo70 exocyst complex subunit family, has weak similarity to exocyst component protein 70 kDa homolog (rat Exo70), which is involved in exocytic vesicle targeting and neuronal differentiation and outgrowth C43E11.9 C43E11.9 Putative ortholog of S. cerevisiae Nip7p, a nucleolar protein required for efficient 60S ribosome subunit biogenesis C43F9.4 C43F9.4 Protein of unknown function C43F9.5 C43F9.5 Protein of unknown function, has low similarity to uncharacterized C. elegans F46E10.B C43F9.6 C43F9.6 Member of the Na+,K+ ATPase beta subunit family, which regulate the number of sodium pumps transported to the plasma membrane, has low similarity to C. elegans C17E4.9p Sodium and potassium ATPases C43F9.7 C43F9.7 Protein of unknown function C43G2.1 C43G2.1 Member of the uncharacterized protein family (Hly-III or UPF0073), which may be hemolysins C43G2.2 C43G2.2 Protein with strong similarity to human Bicaudal D homolog 1 (BICD1) and D. melanogaster (BicD) Bicaudal-D, a cytoskeleton-associated protein required for the correct sorting of mRNAs during oogenesis and embryogenesis cytoskeleton-like protein C43G2.3 C43G2.3 Protein of unknown function C43G2.4 C43G2.4 Member of the C. elegans putative membrane protein family 8, has moderate similarity to a region of bestrophin (human VMD2), which plays a role in vision and is associated with Bests disease, adult vitelliform macular dystrophy, and bull's eye maculopathy C43G2.5 C43G2.5 Protein with moderate similarity to human serine proteases; may be anchored to the membrane of a secretory vesicle or the Golgi apparatus peptidase C43H6.1 C43H6.1 Protein of unknown function C43H6.2 C43H6.2 Protein of unknown function C43H6.3 C43H6.3 Protein containing two ankyrin (Ank) repeats, which may mediate protein-protein interactions, has moderate similarity to granule cell differentiation protein (myotrophin, rat Gcdp), which binds to NF-kappa B in vitro and may be involved in transcription C43H6.4 C43H6.4 Protein of unknown function C43H6.5 C43H6.5 Protein containing a C-type lectin domain, which mediate calcium-dependent carbohydrate recognition C43H6.6 C43H6.6 Protein containing a CUB domain, which often occurs extracellularly in developmentally regulated proteins C43H6.7 C43H6.7 Protein containing a DHHC-type zinc finger (NEW1) domain, has a region of low similarity to a region of S. cerevisiae Erf2p, which is involved in palmitoylation and localization of S. cerevisiae Ras2p C43H6.8 C43H6.8 Protein containing one helix-loop-helix DNA-binding domain, which mediate protein dimerization C43H6.9 glr-7;C43H6.9 Protein containing a ligand-gated ion channel domain, which are found in ionotropic glutamate receptors and NMDA receptors, has low similarity to a region of kainate-selective ionotropic glutamate receptor (rat Grik1), which acts in neurotransmission glutamate receptor; glr-7 encodes a protein containing a ligand-gated ion channel domain and is a predicted non-NMDA type ionotropic glutamate receptor; expressed in the pharyngeal nervous system. C43H8.1 C43H8.1 Protein of unknown function C43H8.2 C43H8.2 Protein of unknown function, has low similarity to uncharacterized human MAF1 C43H8.3 C43H8.3 Protein containing an extracellular laminin G domain C44B11.1 C44B11.1;FAIM Protein with high similarity to fas apoptotic inhibitory molecule (mouse Faim), which inhibits Fas (mouse Tnfrsf6)-mediated poly-ADP ribose polymerase (mouse Adprt1) cleavage and apoptosis and that may play a role in lymphocyte homeostasis C44B11.3 mec-12;C44B11.3 Alpha tubulin required in mechanosensory neurons; putative ortholog of S. cerevisiae TUB3 gene product [Tubulin alpha-3 chain, non-essential] alpha tubulin; mec-12 encodes a novel C. elegans alpha-tubulin that is unique amongst C. elegans alpha tubulins in that it may be subject to post-translational acetylation; MEC-12 is required for normal mechanosensory response to gentle touch, and specifically for formation of the 15-protofilament microtubule bundle present in the touch receptor neurons; mec-12 interacts genetically with mec-5, which encodes a unique C. elegans collagen secreted by the hypodermis; MEC-12 is highly expressed in the touch neurons as well as in several other neurons that do not contains the microfilament bundle, such as the ventral cord motorneurons. C44B11.4 C44B11.4 Protein of unknown function C44B12.1 C44B12.1 Protein of unknown function C44B12.2 ost-1;SPARC;C44B12.2 Calcium binding protein that may be secreted osteonectin C44B12.3 C44B12.3 Protein of unknown function C44B12.4 C44B12.4 Putative ortholog of C. elegans Y55F3AM.2 gene product 7TM chemoreceptor, srx family C44B12.5 C44B12.5 Protein of unknown function C44B12.6 C44B12.6 Protein with strong similarity to C. elegans T22H6.1 gene product C44B12.7 C44B12.7;ost-1 Member of the reverse transcriptase protein family, which are RNA-dependent DNA polymerases, has strong similarity to uncharacterized C. elegans Y51H4A.14 reverse transcriptase C44B7.1 p27;C44B7.1 Putative non-ATPase subunit of 19S proteasome particle C44B7.10 C44B7.10 Member of the adenosine and AMP deaminase and cetyl-CoA hydrolases or transferase families, has a region of low similarity to a region of S. cerevisiae Ach1p, which is an acetyl-CoA hydrolase involved in acetate utilization and sporulation C44B7.11 C44B7.11 Member of the M20, M25, or M40 peptidase family of zinc metalloproteases, has low similarity to uncharacterized C. elegans B0495.7 C44B7.2 C44B7.2 Protein containing six RNA recognition motifs (RRM, RBD, or RNP), has moderate similarity to heterogeneous nuclear ribonucleoprotein L (human HNRPL), which binds RNA and may regulate the stability of human VEGF and the translation of hepatitis C virus RNA C44B7.3 C44B7.3 Protein of unknown function, has low similarity to uncharacterized C. elegans C26D10.5 C44B7.4 C44B7.4 Protein of unknown function C44B7.5 C44B7.5 Protein of unknown function C44B7.6 C44B7.6 Member of the transmembrane amino acid transporter (permease) family, has low similarity to lysosomal amino acid transporter 1 (rat Lyaat1), which transports small neutral amino acids and may export them from neuronal lysosomes C44B7.7 C44B7.7 Protein of unknown function, has similarity to human Hs.12770, PAC clone DJ0777023 C44B7.8 C44B7.8 Protein with high similarity to ATP-binding cassette subfamily D (ALD) member 3 (human ABCD3), which mediates peroxisomal import of fatty acids and fatty acyl-CoAs and is associated with Zellweger syndrome, member of the ATP-binding cassette superfamily ATP-binding protein C44B7.9 C44B7.9 Protein with high similarity to ATP-binding cassette subfamily D member 3 (human ABCD3), which mediates peroxisomal import of fatty acids and fatty acyl-CoAs and is associated with Zellweger syndrome, member of the ABC transporter family peroxisomal membrane protein (PMP70, an ATP-binding transport protein) C44B9.1 C44B9.1 Protein of unknown function C44B9.2 C44B9.2 Protein of unknown function C44B9.3 C44B9.3 Protein with moderate similarity to C. elegans C05B5.4 gene product C44B9.4 C44B9.4 Protein with putative PHD fingers S.pombe hypothetical protein C27F7.07C like C44B9.5 C44B9.5 Protein containing an F-box domain, which serve as a link between a target protein and a ubiquitin-conjugating enzyme This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins. C44C1.1 C44C1.1 Protein of unknown function C44C1.2 C44C1.2 Protein of unknown function, has low similarity to uncharacterized C. elegans R09B5.12 C44C1.3 ncs-1;Ce-ncs-1;C44C1.3 Involved in the sensory integration of food and temperature signals, inhibits rhodopsin phosphorylation in a calcium-dependent manner EF-hand calcium binding proteins; The ncs-1 gene encodes a neuronal calcium sensor protein that, along with calcium, is essential for thermotaxis along isothermal paths in thermal gradients. C44C1.4 C44C1.4 Protein with high similarity to vacuolar protein sorting 45 (mouse Vps45), which binds the SNARE syntaxin 6 (mouse Stx6) and may be involved in vesicle transport, member of the Sec 1 family, which may be involved in secretion yeast vacuolar protein sorting protein 33 (SLP1) C44C1.5 C44C1.5 Protein with weak similarity to alcohol acyl transferase (S. cerevisiae Eht1p), which produces ethylhexanate from ethanol and hexanoyl-CoA C44C10.1 C44C10.1 Protein containing two collagen triple helix repeats, which are found in some extracellular proteins, and a nematode cuticle collagen N-terminal domain, has moderate similarity to C. elegans DPY-7, which is a cuticle collagen collagen C44C10.10 C44C10.10 Protein with weak similarity to C. elegans C44C10.4 DNA repair protein RECN like C44C10.2 C44C10.2 Member of the cytochrome P450 family, has a region of low similarity to cytochrome P450 4B1 (mouse Cyp4b1), which is a cytochrome that converts several compounds to active carcinogens and may function in chemical carcinogenesis in extrahepatic tissues C44C10.3 C44C10.3 Member of the sugar (and other) transporter family, has low similarity to a region of solute carrier family 22 member 3 (mouse Slc22a3), which regulates monoamine transport in the heart and placenta Sugar (and other) transporters C44C10.4 C44C10.4 Putative coiled-coil protein, has similarity to S. cerevisiae Smc1p, a protein involved in chromosome condensation and segregation chromosome segregation protein like C44C10.5 C44C10.5 Protein of unknown function, has similarity to C. elegans C44C10.4 chromosome segregation protein like C44C10.6 C44C10.6 Protein of unknown function C44C10.7 C44C10.7 Protein containing a protein kinase domain, has moderate similarity to uncharacterized C. elegans K08H2.5 serine/threonine kinase C44C10.8 C44C10.8 Protein containing one helix-loop-helix DNA-binding domain, which mediates protein dimerization Helix-loop-helix DNA-binding domain; hnd-1 encodes a Hand bHLH transcription factor required for normal viability, gonadogenesis, and posterior body morphology; HND-1 is required for the formation of both somatic gonadal precursors and primordial germ cells, but not for later gonadogenesis; HND-1 is expressed embryogenesis in embryonic mesodermal precursor cells generating (mostly) body wall muscle, in somatic gonad precursor cells, and in some unidentified head cells; the primary defect in hnd-1 mutants may be, nonautonomously, in mesodermal precursor cells; somatic gonad precursor cells are normally generated in hnd-1 mutants, but not maintained. C44C10.9 C44C10.9 Protein of unknown function C44C11.1 ras-1;ras1;C44C11.1 Protein with high similarity to human RRAS2, which is a small GTP-binding RAS-related GTPase that can trigger malignant transformation of breast epithelial cells upon overexpression, member of the Ras superfamily of GTP binding proteins RAS-related protein; ras-1 is orthologous to the human gene UNKNOWN (PROTEIN FOR MGC:21928) (RRAS2; OMIM:600098), which when mutated leads to disease. C44C11.2 C44C11.2 Protein with weak similarity to C. elegans K04C1.2 gene product C44C3.1 C44C3.1 Protein of unknown function, has high similarity to uncharacterized C. elegans C44C3.5 7TM chemoreceptor, srw family C44C3.10 C44C3.10 Putative ortholog of C. elegans C44C3.6 gene product C44C3.2 C44C3.2 Protein of unknown function, has strong similarity to uncharacterized C. elegans H27D07.1, which is predicted to be a G protein-coupled receptor 7TM chemoreceptor, srw family C44C3.3 C44C3.3 Protein of unknown function, has strong similarity to uncharacterized C. elegans H27D07.4 7TM chemoreceptor, srw family C44C3.5 C44C3.5 Protein of unknown function, has high similarity to uncharacterized C. elegans C44C3.6 7TM chemoreceptor, srw family C44C3.6 C44C3.6 Protein of unknown function, has high similarity to uncharacterized C. elegans K12D9.5, which is predicted to be a G protein-coupled receptor 7TM chemoreceptor, srw family C44C3.7 C44C3.7 Protein of unknown function, has high similarity to uncharacterized C. elegans C03A7.3 7TM chemoreceptor, srw family C44C3.9 C44C3.9 Protein of unknown function, putative paralog of C. elegans H27D07.6 7TM chemoreceptor, srh family C44C8.1 C44C8.1 Protein containing two F-box domains, which serve as a link between a target protein and a ubiquitin-conjugating enzyme, has high similarity to uncharacterized C. elegans C44C8.4 This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins. C44C8.2 C44C8.2 Protein containing two F-box domains, which serve as a link between a target protein and a ubiquitin-conjugating enzyme, has very strong similarity to uncharacterized C. elegans C44C8.3 C44C8.3 C44C8.3 Protein containing two F-box domains, which serve as a link between a target protein and a ubiquitin-conjugating enzyme, has very strong similarity to uncharacterized C. elegans C44C8.2 This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins. C44C8.4 C44C8.4 Protein containing two F-box domains, which serve as a link between a target protein and a ubiquitin-conjugating enzyme, has very strong similarity to uncharacterized C. elegans C44C8.2 This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins. C44C8.6 C44C8.6 Protein with high similarity to MAP kinase-activated protein kinase (human MAPKAPK3), which is phosphorylated by CSBP1, CSBP2, ERK2(MAPK1), and SAPK (MAPK8) MAP kinases, contains two protein kinase domains protein kinase C44E12.1 C44E12.1 Member of the M20, M25, or M40 peptidase family of zinc metalloproteases, has moderate similarity to uncharacterized S. pombe Spcc757.05cp C44E12.3 n2P17;n2P17m2-1;n2P17m3;C44E12.3 Protein of unknown function, has a region of low similarity to a region of potassium channel subfamily K member 9 (TASK-3, human KCNK9), which mediates a K+-selective conductance that is inhibited by acidic extracellular pH and modulated by anesthetics C44E4.1 C44E4.1 Protein containing a DNA polymerase processivity factor domain C44E4.2 C44E4.2 Protein of unknown function C44E4.3 C44E4.3 Protein with high similarity to mitochondrial aspartate aminotransferase (human GOT2), which transfers aspartate amino groups to 2-oxoglutarate forming oxaloacetate and glutamate, contains an aminotransferase class I and II domain aminotransferase C44E4.4 C44E4.4 Protein containing an RNA recognition motif (RRM, RBD, or RNP), has low similarity to Sjogren syndrome antigen B (human SSB), which is an RNA-binding protein that is associated with Sjogren syndrome and systemic lupus erythematosus RNA-binding protein C44E4.5 C44E4.5 Protein with weak similarity to C. elegans T05C3.3 gene product C44E4.6 C44E4.6 Protein with high similarity to acyl-coenzyme-A binding protein (S. cerevisiae Acb1p), which is involved in sphingolipid synthesis, contains an acyl CoA binding domain acyl-CoA-binding protein C44E4.7 C44E4.7 Putative paralog of C. elegans C44E4.1 C44F1.1 C44F1.1 Protein of unknown function C44F1.2 C44F1.2 Protein containing a SAND (Sp100, AIRE-1, NucP41/75 and DEAF-1/suppressin) domain, which may bind DNA, has weak similarity to a region of glucocorticoid modulatory element binding protein 1 (mouse Gmeb1), which may form a complex to regulate transcription SAND domain C44F1.3 lec-4;C44F1.3 Member of the galectin family, which are lectins that bind beta galactosides, has moderate similarity to galectin (C. elegans LEC-1), which is a galactoside-binding lectin galactoside binding lectin; lec-4 encodes a predicted galectin that exhibits sugar binding properties in vitro. C44F1.4 C44F1.4 Protein of unknown function C44F1.5 C44F1.5 Protein containing an adenylate and guanylate cyclase catalytic domain, has weak similarity to adenylate cyclase type 1 (mouse Adcy1), which is a neurospecific, calcium-calmodulin stimulated adenylyl cyclase that converts ATP to cAMP adenylyl cyclase; acy-3 encodes a predicted member of the adenylyl cyclase family with highest similarity to human adenylate cyclase type 5; expressed in the support cells of ciliated neurons, in the head and tail ganglia, in two pairs of neurons in the retrovesicular ganglia, and in the spermatheca. C44H4.1 C44H4.1 Protein containing twelve leucine rich repeats, which mediate protein-protein interactions, has low similarity to a region of C. elegans SYM-1, which is required for attachment of body muscle to cuticle in the absence of MEC-8 Leucine Rich Repeat (2 copies) (6 domains) C44H4.2 sym-5;C44H4.2 Protein containing thirteen leucine rich repeats, which mediate protein-protein interactions, has low similarity to C. elegans SYM-1, which is required for attachment of body muscle to cuticle in absence of MEC-8 Drosophila chaoptin protein like; sym-5 encodes a predicted transmembrane protein that contains 13 contiguous leucine-rich repeats (LRRs) and that is similar to SYM-1, a secreted protein involved in muscle attachment; sym-5 activity appears to be required for embryogenesis and functionally overlaps with that of sym-1 and mec-8 in affecting muscle attachment; in addition, loss of sym-5 activity via RNA-mediated interference (RNAi) in a hypersensitized strain indicates that SYM-5 may also be required for locomotion, body morphology, and normal rates of postembryonic growth. C44H4.3 sym-1;C44H4.3 Protein required for attachment of body muscle to cuticle in absence of MEC-8, member of the leucine rich repeat (LRR) protein family Drosophila chaoptin protein like C44H4.4 C44H4.4 Protein of unknown function C44H4.5 tap-1;C44H4.5 Activator of the MOM-4 protein kinase Protein phosphatase 2C C44H4.6 C44H4.6 Protein containing a protein kinase domain, has moderate similarity to glycogen synthase kinase-3 beta (mouse Gsk3b), which is a serine-threonine protein kinase involved in embryonic development glycogen synthase kinase (CDC2/CDKX subfamily) C44H4.7 C44H4.7 Protein of unknown function, has similarity over a region of the N-terminus to a region of S. cerevisiae mucin Muc1p eor-2 encodes an unfamiliar protein, similar to CG17233 in Drosophila and KIAA1205 in H. sapiens, required for signal transduction by both RAS and Wnt pathways in both excretory system development and P12 fate specification. C44H9.1 C44H9.1 Protein containing a UDP-glucoronosyl and UDP-glucosyl transferase domain, which transfer glycosyl groups to small hydrophobic molecules, has low similarity to UDP glycosyltransferase 2 family polypeptide B7 (human UGT2B7), which glucuronidates lipids UDP-glucuronosyltransferase C44H9.2 C44H9.2 Putative ortholog of C. elegans C44H9.4 gene product NAM7 like protein C44H9.4 C44H9.4 Protein of unknown function, has a region of weak similarity to a region of C. elegans SMG-2, which is involved in nonsense-mediated mRNA decay, mRNA surveillance and RNAi-mediated gene suppression NAM7 like protein C44H9.5 C44H9.5 Protein of unknown function C44H9.6 C44H9.6 Protein with strong similarity to C. elegans C08B6.2 gene product C44H9.7 C44H9.7 Protein of unknown function C44H9.8 C44H9.8 Protein of unknown function C45B11.1 C45B11.1 Protein containing two P21-Rho-binding domains, also known as a Cdc42 Rac interactive binding (CRIB) domains and two protein kinase domains, has moderate similarity to p21(CDKN1A)-activated kinase 4 (human PAK4) serine/threonine kinase (PAK/STE20 subfamily) C45B11.2 C45B11.2 Protein of unknown function, has a region of low similarity to microsomal epoxide hydrolase (human EPHX1), which hydrates reactive epoxides to form dihydrodiols and detoxifies cytochrome p450-generated epoxides from the metabolism of xenobiotics epoxide hydrolase like C45B11.3 C45B11.3 Member of the short-chain dehydrogenase-reductase family, which are NAD- or NADP-dependent oxidoreductases, has high similarity to a region of C. elegans C17G10.8, which is involved in lipid metabolism alcohol dehydrogenase C45B11.4 C45B11.4 Member of the 7-transmembrane chemoreceptor family of G protein-coupled receptors (GPCR), has high similarity to uncharacterized C. elegans T04C12.2 C45B2.1 C45B2.1 Protein of unknown function, has high similarity to uncharacterized C. elegans C45B2.2 C45B2.2 C45B2.2 Protein of unknown function, has high similarity to uncharacterized C. elegans C45B2.1 C45B2.3 C45B2.3 Protein of unknown function, has high similarity to uncharacterized C. elegans C45B2.1 C45B2.4 gbr-5;C45B2.4 Protein containing neurotransmitter-gated ion-channel ligand binding and transmembrane domains, has low similarity to glycine receptor alpha 2 subunit (rat Glra2), which plays an important role in inhibiting neurotransmitter release Glycine receptor; ggr-2 encodes a predicted member of the GABA/ glycine receptor family of ligand-gated chloride channels that affects thermotaxis; expressed in neurons that include SMDV, SMDD, SIAV, CAN, HSN, DD, and is weakly expressed in the egg-laying muscles. C45B2.5 C45B2.5 Protein with high similarity to glutamine synthase (rat Glul), which catalyzes the condensation of glutamate and ammonia to form glutamine and may clear L-glutamate from neuronal synapses, contains one glutamine synthetase domain Glutamine synthetase C45B2.6 C45B2.6 Member of the palatin family, which are storage proteins that may also catalyze the cleavage of fatty acids from membrane lipids, contains three ankyrin (Ank) repeats, has a region of low similarity to a region of group VI phospholipase A2 (human PLA2G6) C45B2.7 ptr-4;C45B2.7 Has similarity to several C. elegans proteins of unknown function that may be related to H. sapiens NPC1 (involved in Niemann-Pick disease) C45B2.8 C45B2.8 Protein of unknown function C45E1.1 nhr-64;C45E1.1 Member of the nuclear hormone receptor/Zinc finger protein family hormone receptor/zinc finger protein; nhr-64 encodes a conserved nuclear receptor that is a member of the NR2 subfamily of nuclear receptors that contains Drosophila and human HNF4 (OMIM:600281, mutations in human HNF4A are associated with Type I MODY (maturity-onset diabetes of the young)); by homology, NHR-64 is predicted to function as a transcription factor that may activate or repress transcription in response to a hormonal signal; however, as loss of nhr-64 activity via RNAi does not result in any obvious abnormalities, the precise role of NHR-64 in C. elegans development and/or behavior is not yet known; nhr-64 is broadly expressed and detected in anterior and posterior neurons, the ventral nerve cord, the pharynx, gut, and hypodermis. C45E1.4 C45E1.4 Putative ortholog of C. elegans C45E1.3 gene product C45E5.1 C45E5.1 Member of the haloacid dehalogenase or epoxide hydrolase family, has low similarity to S. cerevisiae Pho13p, which is a 4-Nitrophenylphosphatase C45E5.2 C45E5.2 Member of the glycosyl hydrolase 18 family, has a region of low similarity to chitinase 3-like 1 (cartilage glycoprotein-39, human CHI3L1), which binds chitin but lacks chitinase activity and is expressed in rheumatoid arthritis cartilage C45E5.3 C45E5.3 Member of the glycosyl hydrolase 18 family, has low similarity to chitinase 3-like 1 (cartilage glycoprotein-39, human CHI3L1), which binds chitin but does not have chitinase activity and is expressed in rheumatoid arthritis cartilage and synovial cells C45E5.4 C45E5.4 Protein of unknown function C45E5.5 H35B03.2;C45E5.5 Protein of unknown function, has a region of low similarity to subunit p30 of ribonuclease P (human RPP30), which processes 5' ends of precursor tRNAs and is associated with systemic sclerosis C45E5.6 nhr-46;C45E5.6 Member of the nuclear hormone receptor, C4-type zinc finger protein family nuclear hormone receptor C45G3.1 C45G3.1 Protein containing two IQ calmodulin-binding domains Actinin-type actin-binding domain containing proteins; The C45G3.1 gene encodes a protein, with one N-terminal calponin-like actin-binding domain and two IQ calmodulin-binding domains, that is likely to be required for spindle structure and function, and (indirectly) for neural function, based on its orthology to Drosophila ABNORMAL SPINDLE and on its joint sterile and uncoordinated RNAi phenotypes; C45G3.1 is also orthologous to human ASPM (OMIM:605481), which when mutated leads to primary microcephaly; C45G3.1 is required for embryonic and larval viability, germline maintenance, vulval morphogenesis, meiosis, and locomotion. C45G3.2 C45G3.2 Protein with weak similarity to H. sapiens Hs.129917 (Homo sapiens mRNA for triple LIM domain protein) C45G3.3 C45G3.3 Member of the biotin or lipoate A-B protein ligase family, which catalyze biotin or lipoic acid attachment to enzymes gip-2 encodes a member of the Biotin/lipoate A/B protein ligase family. C45G3.4 C45G3.4 Protein of unknown function C45G7.1 C45G7.1 Protein with moderate similarity to C. elegans F22A3.6, which is a possible lysozyme C45G7.2 C45G7.2 Protein with strong similarity to C. elegans F22A3.6, which is a possible lysozyme C45G7.4 C45G7.4 Protein containing a C3HC4 type (RING) zinc finger, which may mediate protein-protein interactions zinc finger protein C45G7.6 cdh-10;C45G7.5;C45G7.6 Protein containing three cadherin domains, which are found in the extracellular domain of receptors and cell adhesion proteins, has a region of weak similarity to a region of cadherin 23 (otocadherin, mouse Cdh23), which is involved in vestibular function C45G9.1 C45G9.1 Protein containing a protein kinase domain, has low similarity to a region of S. cerevisiae Hrr25p, which is a casein kinase I (serine/threonine/tyrosine protein kinase) involved in DNA repair and meiosis Protein kinase C45G9.10 C45G9.10 Protein of unknown function C45G9.11 C45G9.11 Protein of unknown function C45G9.12 C45G9.12 Protein of unknown function C45G9.2 C45G9.2 Member of the uncharacterized protein family UPF0034, has high similarity to uncharacterized human PP35 This gene encodes a protein predicted by Eisenberg and coworkers, with 52% accuracy, to be mitochondrial. C45G9.4 C45G9.4 Protein of unknown function, has very strong similarity to uncharacterized C. elegans C45G9.9 C45G9.5 C45G9.5 Protein of unknown function C45G9.6 C45G9.6 Protein of unknown function C45G9.7 C45G9.7 Member of the PDZ domain (also known as DHR Or GLGF) protein family C45G9.8 C45G9.8 Protein of unknown function, has moderate similarity to uncharacterized C. elegans Y75B7B.1 C45G9.9 C45G9.9 Protein of unknown function, has very strong similarity to uncharacterized C. elegans C45G9.4 C45H4.1 C45H4.1 G protein-coupled receptor of an unnamed subfamily, no homolog found in human or D. melanogaster C45H4.10 C45H4.10 Protein containing a DUF40 domain of unknown function, which contain four conserved cysteines, has moderate similarity to uncharacterized C. elegans F40D4.6 C45H4.11 C45H4.11 Protein containing a DUF40 domain of unknown function, which contain four conserved cysteines C45H4.12 C45H4.12 Member of the 7-transmembrane chemoreceptor family of G protein-coupled receptors (GPCR), has high similarity to uncharacterized C. elegans T23F1.4 7TM chemoreceptor, str family C45H4.13 C45H4.13 Protein of unknown function C45H4.14 C45H4.14 Protein of unknown function, has high similarity to uncharacterized C. elegans Y5H2B.3 C45H4.15 C45H4.15 Member of the 7-transmembrane chemoreceptor family of G protein-coupled receptors (GPCR), has low similarity to C. elegans ODR-10, which is a G protein-coupled receptor involved in odorant response 7TM chemoreceptor, str family C45H4.16 C45H4.16 Protein containing a DUF40 domain of unknown function, which contain four conserved cysteines, has high similarity to uncharacterized C. elegans K09C6.5 C45H4.17 C45H4.17 Member of the cytochrome P450 family, has low similarity to cytochrome P450 subfamily 2J polypeptide 4 (rat Cyp2j4), which is a monooxygenase that converts arachidonic acid to hydroxyeicosatetraenoic and epoxyeicosatrienoic acids cytochrome P450 C45H4.2 C45H4.2 Member of the cytochrome P450 family, has low similarity to cytochrome P450 subfamily IIE 1 (human CYP2E), which is a monooxygenase involved in xenobiotic, ethanol, and fatty acid metabolism, apoptosis, and oxidative stress cytochrome P450 C45H4.3 C45H4.3 G protein-coupled receptor, member of unnamed subfamily with distant homology to SRG subfamily, no homolog found in human or D. melanogaster C45H4.5 C45H4.5 Member of the transposase family, which are required for excising and inserting mobile genetic elements, has high similarity to uncharacterized C. elegans Y51H4A.H C45H4.6 C45H4.6 Protein containing a DUF40 domain of unknown function, which contain four conserved cysteines C45H4.7 C45H4.7 Protein containing a DUF40 domain of unknown function, which contain four conserved cysteines, has high similarity to uncharacterized C. elegans C45H4.8 C45H4.8 C45H4.8 Protein containing a DUF40 domain of unknown function, which contain four conserved cysteines, has high similarity to uncharacterized C. elegans C45H4.7 C45H4.9 C45H4.9 Protein containing a DUF40 domain of unknown function, which contain four conserved cysteines, has moderate similarity to uncharacterized C. elegans C45H4.8 C46A5.1 C46A5.1 Member of the protein-tyrosine phosphatase family, which are involved in control of cell growth, proliferation, and differentiation, has a region of low similarity to a region of human PTPN2, which is a non-receptor protein tyrosine phosphatase protein-tyrosine phosphatase C46A5.2 C46A5.2 Member of the amiloride-sensitive sodium channel family, which are involved in sodium reabsorption C46A5.3 col-14;col14;C46A5.3 Collagen cuticular collagen; col-14 encodes a collagen protein that affects vulval morphology in a large-scale RNAi screen; mRNA expressed in embryos and transcript levels peak during each larval stage. C46A5.4 C46A5.4 Member of the animal heme peroxidase family, has a region of moderate similarity to a region of melanoma associated gene (human D2S448), which is a tumor antigen and possible peroxidase that may play a role in apoptosis and immune responses peroxidase C46A5.5 C46A5.5 Protein of unknown function C46A5.6 C46A5.6 Protein of unknown function C46A5.8 C46A5.8 Protein of unknown function C46A5.9 hcf-1;C46A5.9 Protein containing three Kelch motif domains, has moderate similarity to host cell factor 2 (human HCF-2), which is a transcriptional co-activator that is involved in promoting Herpes simplex viral (HSV) transcription factor VP16-induced complex formation C46C11.1 C46C11.1 Protein with low similarity to hormone-sensitive lipase (human LIPE), which is a triacylglycerol lipase involved in fatty acid mobilization, energy homeostasis and steroidogenesis hormone sensitive lipase C46C11.2 C46C11.2 Protein of unknown function, has weak similarity to C. elegans F40F9.5 C46C11.3 C46C11.3 Protein of unknown function C46C2.1 C46C2.1 Protein containing a protein kinase domain, has low similarity to protein kinase with no lysine 1 (rat Prkwnk1), which is a serine/threonine kinase whose catalytic lysine is located in subdomain I, not in subdomain II serine/threonine kinase; wnk-1 is orthologous to the human gene PROTEIN KINASE, LYSINE-DEFICIENT 1 (PRKWNK1; OMIM:605232), which when mutated leads to pseudohypoaldosteronism type II. C46C2.2 C46C2.2 Member of the sugar (and other) transporter family, has low similarity to C. elegans OCT-1, which is an organic cation membrane transporter with broad substrate specificity transport protein C46C2.3 C46C2.3 Protein with moderate similarity to C. elegans T24H10.5 gene product C46C2.4 C46C2.4 Member of the alpha or beta hydrolase fold family, has a region of low similarity to dipeptidyl peptidase II (quiescent cell proline dipeptidase, rat Dpp7), which is a serine protease that may be involved in the response to wounding alpha/beta hydrolase fold C46C2.5 C46C2.5 Protein of unknown function, has weak similarity to C. elegans F53H4.2 C46E1.1 C46E1.1 Protein of unknown function C46E1.2 gcy-36;C46E1.2 Protein containing an adenylate and guanylate cyclase catalytic domain, has moderate similarity to rat Gucy1b2, which is the beta 2 subunit of the enzyme guanylate cyclase that converts GTP to cGMP GUANYLATE CYCLASE SOLUBLE, BETA-2 CHAIN (EC 4.6.1.2) (76 KD CHAIN); gcy-36 encodes a predicted soluble guanylate cyclase that genetically interacts with npr-1 with respect to feeding behavior; expressed in AQR, PQR, and URX3. C46E10.1 C46E10.1 Protein of unknown function, has similarity to C. elegans Y71F9A_291.A C46E10.10 C46E10.10 Protein with similarity to G protein-coupled receptors 7TM chemoreceptor, srh family C46E10.2 C46E10.2 Protein with strong similarity to C. elegans E04F6.14 gene product C46E10.3 C46E10.3 Protein containing a coiled-coil region overlapping a bZIP domain, has weak similarity to a region of human TPR (translocated promoter region, a nuclear pore complex-associated protein involved in activation of oncogenic kinases) C46E10.4 C46E10.4 Protein of unknown function, has low similarity to uncharacterized C. elegans C46E10.5 C46E10.5 C46E10.5 Protein of unknown function, has low similarity to uncharacterized C. elegans C46E10.4 C46E10.6 C46E10.6 Protein of unknown function, has high similarity to uncharacterized C. elegans F40H7.2 7TM chemoreceptor, srx family C46E10.7 C46E10.7 Member of the 7-transmembrane chemoreceptor family of G protein-coupled receptors (GPCR), has strong similarity to uncharacterized C. elegans C46E10.10 7TM chemoreceptor, srh family C46E10.8 C46E10.8 Protein containing two C2H2 type zinc finger domains, which bind nucleic acids zinc finger protein C46E10.9 C46E10.9 Protein containing six C2H2 type zinc finger domains, has a region of low similarity to human ZNF146, which is a zinc finger that may be involved in the development or progression of pancreatic carcinomas zinc finger protein C46F11.1 unc-93;C46F11.1 Putative membrane protein involved in muscle action UNC-93 protein; A novel putative transmembrane protein that affects muscle contraction and egg-laying; it is predicted to be a component of a two-pore potassium channel complex together with SUP-9 and SUP-10; it is expressed in head neurons including the four SIA neurons. C46F11.2 C46F11.2 Protein with high similarity to glutathione reductase (human GSR), which protects against oxidative injury, member of the pyridine nucleotide-disulphide oxidoreductase family, contains one pyridine nucleotide-disulphide oxidoreductase dimerization domain pyridine nucleotide-disulphide oxidoreductases class-I; C46F11.2 is orthologous to human MITOCHONDRIAL GLUTATHIONE REDUCTASE (GSR; OMIM:138300); GSR deficiency has been associated with hemolytic anemia. C46F11.3 C46F11.3 Protein of unknown function C46F11.4 C46F11.4 Member of the DEAD or DEAH box ATP-dependent RNA helicase family and contains a helicase conserved C-terminal domain, has low similarity to S. cerevisiae Prp5p, which is a pre-mRNA processing RNA helicase and snRNA-associated spliceosomal protein ATP-dependent RNA helicase C46F11.5 C46F11.5 Protein of unknown function C46F2.1 C46F2.1 Protein of unknown function C46F4.1 C46F4.1 Member of the rhodopsin family of G protein-coupled receptors (GPCR), has weak similarity to uncharacterized C. elegans F57B7.1 C46F4.2 C46F4.2 Protein with high similarity to long-chain fatty acid-Coenzyme A ligase 4 (human FACL4), which functions in lipid metabolism, anti-apoptosis, possibly in learning, and may be associated with Alport syndrome, member of the AMP-binding enzyme family long-chain-fatty-acid coA ligase C46F9.1 C46F9.1 Protein containing four meprin and TRAF homology (MATH) domains, has high similarity to uncharacterized C. elegans C46F9.3 C46F9.2 C46F9.2 Protein containing three meprin and TRAF homology (MATH) domains, has high similarity to uncharacterized C. elegans C46F9.3 The C46F9.2 gene encodes a protein closely similar to C46F9.3, which has a meprin-associated Traf homology (MATH) domain and may be involved in apoptosis. C46F9.3 C46F9.3 Protein containing three meprin and TRAF homology (MATH) domains, has high similarity to uncharacterized C. elegans C46F9.2 The C46F9.3 gene encodes a protein with a meprin-associated Traf homology (MATH) domain that may be involved in apoptosis. C46F9.4 C46F9.4 Protein containing three meprin and TRAF homology (MATH) domains, has high similarity to uncharacterized C. elegans C46F9.2 C46G7.1 C46G7.1 Protein of unknown function C46G7.2 C46G7.2 Alpha-filagenin, component of core of myosin thick filaments in body wall muscle C46G7.3 C46G7.3 Protein with strong similarity to C. elegans F07B7.6 gene product C46G7.4 C46G7.4 Protein of unknown function The protein product of this gene is predicted to contain a glutamine/asparagine (Q/N)-rich ('prion') domain, by the algorithm of Michelitsch and Weissman (as of the WS77 release of WormBase, i.e., in wormpep77). C46H11.1 C46H11.1 Protein of unknown function C46H11.10 C46H11.10 Protein of unknown function C46H11.11 C46H11.11 Protein containing two formin homology 2 domains, which are found in proteins that control rearrangements of the actin cytoskeleton, has low similarity to formin homology 2 domain containing 1 (human FHOD1), which interacts with human RAC1 GTPase C46H11.2 C46H11.2 Member of the flavin-binding monooxygenase family, which are xenobiotic-metabolising enzymes, has low similarity to flavin containing monooxygenase 3 (mouse Fmo3), which is a dimethylaniline monooxygenase associated with trimethylaminuria upon mutation This gene encodes a protein predicted by Eisenberg and coworkers, with 52% accuracy, to be mitochondrial. C46H11.3 AR16;C46H11.3 Protein of unknown function, has high similarity to uncharacterized C. elegans M01B12.3 C46H11.4 lfe-2;C46H11.5;C46H11.4 Inositol (1,4,5) triphosphate kinase C46H11.6 C46H11.6 Putative paralog of C. elegans F28E10.4 gene product C46H11.7 C46H11.7 Protein containing a DUF18 domain of unknown function, has high similarity to uncharacterized C. elegans C46H11.9 C46H11.8 C46H11.8 Protein containing a DUF18 domain of unknown function C46H11.9 C46H11.9 Protein containing a DUF18 domain of unknown function, has high similarity to uncharacterized C. elegans C46H11.7 C46H3.1 C46H3.1 Protein of unknown function C46H3.2 C46H3.2 Protein containing a Src homology 3 (SH3) domain, which bind proline-rich peptides and two SAM (sterile alpha motif) domains, which may mediate protein-protein interactions tyrosine-protein kinase C46H3.3 C46H3.3 Protein containing ankyrin (Ank) repeats, which may mediate protein-protein interactions, has low similarity to a region of ankyrin (rat Ank3), which is an anchoring protein that links integral membrane proteins to the cytoskeleton ankyrin C47A10.1 C47A10.1 Probable membrane transporter of the ATP-binding cassette (ABC) superfamily, has strong similarity to human multidrug resistance proteins PGY1 and PGY3, has strong similarity to D. melanogaster multidrug resistance proteins MDR49 and MDR65 multidrug resistance protein (p-glycoprotein) (2 domains) C47A10.2 C47A10.2 Member of the 7-transmembrane chemoreceptor family of G protein-coupled receptors (GPCR), has high similarity to uncharacterized C. elegans C47A10.3 C47A10.3 C47A10.3 Member of the 7-transmembrane chemoreceptor family of G protein-coupled receptors (GPCR), has high similarity to uncharacterized C. elegans C47A10.2 C47A10.4 C47A10.4 Member of the C. elegans Sre G protein-coupled chemoreceptor family, which are putative chemosensory receptors 7TM receptor, sre family; C47A10.4 is orthologous to the human gene ALBINISM, OCULAR, TYPE I (OA1; OMIM:300500), which when mutated leads to Nettleship-Falls type ocular albinism. C47A10.5 C47A10.5 Member of the FAD dependent oxidoreductase family, has low similarity to D-amino-acid oxidase (mouse Dao1), which catalyzes the oxidation of neutral and basic D-amino acids into the corresponding keto acids and may affect the activity of NMDA receptors D-amino acid oxidase C47A10.6 C47A10.6 Member of C. elegans Sra integral membrane protein family, which contain 6-7 hydrophobic, putative transmembrane, regions, has low similarity to uncharacterized C. elegans R13D11.6 C47A10.8 C47A10.8 Protein of unknown function, has high similarity to uncharacterized C. elegans F55B12.8 7TM receptor, srx family C47A4.1 C47A4.1 Putative ortholog of C. elegans B0035.2 gene product C47A4.2 C47A4.2 Member of the nucleoside transporter family, which transport nucleosides across the plasma, and possibly nuclear, membrane, has weak similarity to solute carrier family 29 member 1 (rat Slc29a1), which transports nucleosides and nucleoside analog drugs C47A4.3 C47A4.3 Protein with high similarity to rat Ppp1cb, which is the catalytic subunit of a serine-threonine phosphatase that regulates many metabolic processes, member of the serine or threonine protein phosphatase family Ser/Thr protein phosphatase C47A4.5 C47A4.5 Protein of unknown function, has very strong similarity to uncharacterized C. elegans Y45F10B.3 C47B2.1 C47B2.1 Protein of unknown function, has weak similarity to C. elegans F36G9.14 This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins; this gene's encoded protein also contains an FTH/DUF38 motif, which may also mediate protein-protein interaction. C47B2.2 C47B2.2 Protein of unknown function, has a region of moderate similarity to a region of uracil phosphoribosyltransferase (S. cerevisiae Fur1p), which is part of the pyrimidine salvage pathway C47B2.3 tba-2;alpha-2;C47B2.3 Alpha tubulin Tubulin; tba-2 encodes a tubulin with similarity to the murine alpha-2 chain; in small scale assays tba-1(RNAi) has no phenotype and was found to function redundantly with its isotype tba-1 to form spindle structures in embryos with the tbb-1 and tbb-2 beta-isotypes. C47B2.4 pbs-2;C47B2.4 Putative beta-type subunit of 20S proteasome particle Proteasome A-type and B-type C47B2.5 C47B2.5 Protein with high similarity to integrin beta 4 binding protein (translation initiation factor eIF6, human ITGB4BP), which prevents formation of the 80S ribosome, member of the eukaryotic translation initation factor 6 (eIF-6) family EUKARYOTIC TRANSLATION INITIATION FACTOR 6 (EIF-6) C47B2.6 C47B2.6 Protein with high similarity to UDP-galactose-4-epimerase (human GALE), which catalyzes the interconversion of UDP galactose and UDP glucose in the galactose metabolic pathway, member of the NAD-dependent epimerase or dehydratase family NAD dependant epimerase/dehydratase family; The C47B2.6 gene encodes an ortholog of the human gene UDP-GALACTOSE-4-EPIMERASE (GALE; OMIM:606953), which when mutated leads to galactose epimerase deficiency (OMIM:230350). C47B2.7 C47B2.7 Protein containing three elongation factor Tu GTP binding domains and an elongation factor Tu domain 2, which are involved in binding charged tRNA, has low similarity to selenocysteine-tRNA-specific eukaryotic elongation factor (mouse Eefsec) Elongation factor Tu family (contains ATP/GTP binding P-loop); C47B2.7 encodes an ortholog of the mammalian selenocysteine-specific elongation factor SelB (e.g., murine mSelB); mSelB binds GTP, recognizes the Sec-tRNA(Sec) in vitro and in vivo, and is required for efficient selenoprotein translation in vivo, but is unable to bind specifically the eukaryotic SECIS RNA hairpin (apparently requiring at least one other specialized protein). C47B2.8 C47B2.8 Protein of unknown function C47B2.9 C47B2.9 Protein of unknown function C47C12.1 deg-1;C47C12.6;C47C12.1 Member of the amiloride-sensitive sodium channel family, has similarity to human and D. melanogaster amiloride-sensitive cation channels C47C12.2 C47C12.2 Protein of unknown function C47C12.3 C47C12.3 Protein containing four C2H2 type zinc finger domains, has a region of high similarity to a region of zinc finger protein of the cerebellum 1 (mouse Zic1), which functions in cerebellar granule cell proliferation and possibly in cerebellar differentiation zinc finger protein; ref-2 is orthologous to the human gene ZINC FINGER PROTEIN OF CEREBELLUM ZIC2 (ZIC2; OMIM:603073), which when mutated leads to disease. C47C12.4 C47C12.4 Protein containing an EF hand domain, which are found in signaling, buffering or transport proteins, has high similarity to uncharacterized C. elegans K08F11.5 ATP/GTP-binding protein C47C12.5 C47C12.5 Protein of unknown function C47D12.1 C47D12.1;kel-1 Protein containing a FATC (FRAP, ATM, TRRAP C-terminal) domain, a FAT (FRAP, ATM and TRRAP) domain, and a phosphatidylinositol 3- and 4-kinase domain, has weak similarity to transformation transcription domain-associated protein (human TRRAP) Yeast YHP9 like C47D12.2 C47D12.2 Protein of unknown function C47D12.3 C47D12.3 Member of the mitochondrial tricarboxylate carrier (MTC) protein family C47D12.4 C47D12.4 Protein of unknown function, has strong similarity to C. elegans F15A4.2 This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins. C47D12.5 C47D12.5 Protein with strong similarity to C. elegans C17G1.2 gene product C47D12.6 C47D12.6 Protein with high similarity to threonyl-tRNA synthetase (human TARS), which is a class II aminoacyl tRNA synthetase, contains anticodon binding, tRNA synthetase class II core and TGS (ThrRS, GTPase and SpoT) domains threonyl-tRNA synthetase (cytoplasmic); This gene encodes a protein predicted by Eisenberg and coworkers, with 52% accuracy, to be mitochondrial. C47D12.7 kel-1;C47D12.7 Putative KELCH protein, has strong similarity to D. melanogaster KEL and human human KIAA0132 (Kelch-like ECH-associated protein 1), contains an N-terminal BTB/POZ domain and six C-terminal kelch motifs ring canal protein like; kel-1 encodes a BTB/POZ- and Kelch motif-containing protein orthologous to Drosophila Kelch, which is essential for actin organization in ovarian ring canals; in C. elegans, kel-1 is required for regulating feeding during larval development and more specifically, for pharyngeal isthmus peristalsis and efficient trapping of food in the pharynx; KEL-1 is first expressed at the 1.5-fold stage of embryogenesis in the pharyngeal lumen and the nerve ring; later adult and larval expression is confined to the pharyngeal gland cells in which KEL-1 may be required for maintenance of gland cell-specific structures. C47D12.8 C47D12.8 Protein containing an ERCC4 domain, which may modify DNA, has low similarity to excision repair cross complementing 4 (human ERCC4), which is an endonuclease participating in nucleotide excision repair that is associated with xeroderma pigmentosum group F DNA repair protein RAD16 like; C47D12.8 is orthologous to the human gene DNA REPAIR PROTEIN (ERCC4; OMIM:133520), which when mutated leads to disease. C47D2.1 C47D2.1 Protein of unknown function C47D2.2 C47D2.2 Protein containing a cytidine deaminase zinc-binding domain, has moderate similarity to cytidine deaminase (human CDA), which deaminates cytidine and deoxycytidine to uridine and deoxyuridine cytidine deaminase; cdd-1 encodes a cytidine deaminase that contains a zinc-binding region; expressed in the intestine. C47E12.1 C47E12.1 Protein with high similarity to seryl-tRNA synthetase (human SARS), which aminoacylates seryl-tRNA with serine for protein biosynthesis, contains a seryl-tRNA synthetase N-terminal domain and a tRNA synthetase class II core domain (G, H, P, S and T) seryl-tRNA synthetase; srs-2 encodes a predicted cytoplasmic seryl-tRNA synthetase (SerRS), a class II aminoacyl-tRNA synthetase that catalyzes the attachment of serine to its cognate tRNA and is thus required for protein biosynthesis; in C. elegans, SRS-2 activity is required for embryonic and germline development and normal postembryonic growth rates. C47E12.10 C47E12.10 Protein containing a DUF236 domain of unknown function, has high similarity to uncharacterized C. elegans R08A2.1 C47E12.11 C47E12.11 Protein of unknown function, has moderate similarity to uncharacterized C. elegans F02E9.3 C47E12.2 C47E12.2 Protein with high similarity to solute carrier family 25 member 4 (mouse Slc25a4), which is an adenine nucleotide translocator required for metabolism that can induce apoptosis, member of the mitochondrial carrier protein family of membrane transporters ADP/ATP carrier protein C47E12.3 C47E12.3 Member of the glycosyl hydrolase 47 family of alpha-mannosidases, which hydrolyze terminal mannose residues, has moderate similarity to a region of S. cerevisiae Mnl1p, which is involved in endoplasmic reticulum-associated degradation of glycoproteins alpha-mannosidase C47E12.4 C47E12.4 Protein with high similarity to S. cerevisiae Ipp1p, which is a cytoplasmic inorganic pyrophosphatase, member of the inorganic pyrophosphatase family, which catalyze hydrolysis of pyrophosphate formed as product of biosynthetic reactions utilizing ATP inorganic pyrophosphatase C47E12.5 C47E12.5 Protein with high similarity to ubiquitin-activating enzyme E1 (mouse Ube1x), which activates ubiquitin to mark proteins for proteasomal degradation, member of the UBA-THIF-type NAD-FAD binding fold family that also contains a UBACT repeat ubiquitin-activating enzyme; uba-1 encodes a ubiquitin-activating enzyme orthologous to Saccharomyces cerevisiae UBA1 and human UBE1; UBA-1 is essential for embryogenesis and is required for germline development; by homology, UBA-1 is predicted to function in an ATP-dependent reaction that activates ubiquitin prior to its conjugation to proteins that will subsequently be degraded by the 26S proteasome. | uba-1 encodes a ubiquitin-activating enzyme orthologous to Saccharomyces cerevisiae UBA1 and human UBE1; UBA-1 is essential for embryogenesis and is required for germline development; by homology, UBA-1 is predicted to function in an ATP-dependent reaction that activates ubiquitin prior to its conjugation to proteins that will subsequently be degraded by the 26S proteasome; a uba-1 transcriptional reporter fusion is expressed in the larval intestine. C47E12.6 C47E12.6 Protein with strong similarity to C. elegans K09B11.10 gene product C47E12.7 C47E12.7 Protein with similarity to human NNP-1/NOP52, novel nucleolar protein Yeast YD78 like C47E12.8 dhp-2;CeCRMP;UlipA;C47E12.8 Putative dihydropyrimidinase, has strong similarity to C. elegans R06C7.3 and several human dihydropyrimidinases Ulip like protein; The dhp-2 gene encodes an ortholog of the human gene DIHYDROPYRIMIDINASE (DPYS), which when mutated leads to dihydropyrimidinuria (OMIM:222748). C47E12.9 C47E12.9 Protein of unknown function C47E8.1 C47E8.1 Protein of unknown function C47E8.2 C47E8.2 Member of the 7-transmembrane chemoreceptor family of G protein-coupled receptors (GPCR) G-protein coupled receptor, srh family C47E8.3 C47E8.3 Protein of unknown function, has weak similarity to uncharacterized C. elegans E04D5.2 C47E8.4 C47E8.4 Protein of unknown function, has moderate similarity to uncharacterized human DXS9928E C47E8.5 daf-21;HSP90;C47E8.5 Heat shock protein 90, and apparently the only C. elegans ortholog of human Hsp90; involved in dauer larva formation heat shock protein (HSP90); daf-21 encodes a member of the Hsp90 family of molecular chaperones; DAF-21 activity is required for larval development, negative regulation of dauer larva formation, and a number of specific chemosensory behaviors, such as the response to chemicals and odorants detected by the ASE and AWC sensory neurons; a daf-21 sensory defect can be rescued by a cyclic GMP analogue, suggesting that, in regulating chemosensory behaviors, DAF-21 acts at a similar point as the DAF-11 guanylyl cyclase; down-regulation of daf-21 via RNAi results in a small but reproducible reduction in age-1 life span, suggesting that daf-21 is part of a chaperone network required for the extended life span seen in age-1 mutant animals. C47E8.6 C47E8.6 Putative coiled-coil protein, has weak similarity to S. cerevisiae Uso1p C47E8.7 unc-112;C47E8.7 Muscle protein; functions in the attachment of the myofilament lattice to basal cell membranes mitogen inducible MIG-2 protein like; The unc-112 gene encodes a pleckstrin homology domain-containing protein, orthologous to human Mitogen inducible gene-2, that is required for assembly of muscle dense bodies and M lines during embryogenesis; UNC-112 is a dense body/M-line component and requires PAT-3/beta-integrin, UNC-52/perlecan, and PAT-4/integrin-linked kinase for proper localization; UNC-112 binds PAT-4 directly, forms a ternary complex with PAT-4 and PAT-6/actopaxin, and is required for recruitment of PAT-3 and PAT-4 to muscle cell attachment sites; viable unc-112 mutations are suppressed by mutation of dim-1. C47E8.8 C47E8.8 Protein containing a SET domain, which are involved in protein-protein interactions, has a region of weak similarity to a region of cell surface flocculin (S. cerevisiae Muc1p), which is required for invasive and pseudohyphal growth SET domain C47F8.1 C47F8.1 Protein of unknown function, has weak similarity to C. elegans F35E2.8 This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins. C47F8.2 C47F8.2 Protein containing a nuclear hormone receptor C4-type zinc finger domain, has a region of moderate similarity to a region of estrogen related receptor gamma (mouse Esrrg), which binds to DNA at estrogen response elements and activates transcription Zinc finger, C4 type (two domains) C47F8.3 C47F8.3 Member of the galactosyltransferase family, which transfer galactose to GlcNAc termini of growing oligosaccharide chains, has low similarity to UDP-galactose:beta-N-acetylglucosamine beta 1,3-galactosyltransferase (mouse B3galt1) C47F8.4 C47F8.4 Protein with moderate similarity to beta-1,3-glucuronyltransferase 3 (glucuronosyltransferase I, human B3GAT3), which is a type II transmembrane protein that catalyzes the transfer of a glucuronic acid to a specific trisaccharide primer C47F8.5 C47F8.5 Member of the galactosyltransferase family, which transfer galactose to GlcNAc termini of growing oligosaccharide chains, has a region of low similarity to a region of UDP-GlcNAc:betaGal beta-1-3-N-acetylglucosaminyltransferase 5 (human B3GNT5) C47F8.6 C47F8.6 Member of the galactosyltransferase family, which transfer galactose to GlcNAc termini of growing oligosaccharide chains, has a region of low similarity to UDP-galactose:beta-N-acetylglucosamine beta 1,3-galactosyltransferase (mouse B3galt1) C47F8.7 C47F8.7 Protein of unknown function, has weak similarity to C. elegans T02H6.C C47F8.8 nhr-81;C47F8.8 Member of the zinc finger protein family with similarity to nuclear hormone receptors Zinc finger, C4 type (two domains) C47G2.1 cut-1;vmp-1;C47G2.1 Cuticulin component cuticulin; cut-1 encodes a component of cuticlin, an insoluble residue of the nematode cuticle required for alae formation and radial shrinking during dauer differentiation; expressed specifically in the cuticle of dauer larvae and is secreted by the seam cells. C47G2.2 unc-130;C47G2.2 Transcription factor that contains a forkhead (FH) domain fork head domain protein; A member of the forkhead domain family of transcription factors that affects the generation of the AWA and ASG chemosensory neurons and is partially required for male tail morphogenesis and embryogenesis; it is expressed in the AWA and ASG precursors; it is required for the graded spatial expression of the UNC-129 TGF-beta guidance factor. C47G2.3 C47G2.3 Protein of unknown function C47G2.4 C47G2.4 Protein of unknown function, has weak similarity to S. pombe Spcc622.11p C47G2.5 C47G2.5 Protein of unknown function, has a region of moderate similarity to H. sapiens Hs.153121 gene product C48A7.1 egl-19;eat-12;pat-5;C48A7.1 Putative alpha1 subunit of the voltage-dependent calcium channel required for muscle depolarization calcium channel alpha subunit; egl-19 encodes an ortholog of the alpha subunit of mammalian L-type calcium ion channels that affects muscle contraction in late embryonic morphogenesis, movement, egg-laying, mating and feeding; egl-19 is expressed in muscle cells and some neurons. C48A7.2 C48A7.2 Member of the phosphate transporter family, has low similarity to solute carrier family 20 member 1 (human SLC20A1), which is a high-affinity sodium-inorganic phosphate cotransporter that plays a role in phosphate transport and metabolism phosphate permease C48B4.1 C48B4.1 Member of the acyl-CoA oxidase family, which convert acyl-CoA into trans-2-enoyl-CoA, has moderate similarity to peroxisomal acyl-coenzyme A oxidase (human ACOX1), which catalyzes the first step in very long chain fatty acid beta-oxidation Acyl-CoA oxidase I C48B4.10 C48B4.10 Protein of unknown function, has weak similarity to C. elegans C48B4.6 C48B4.11 C48B4.11 Protein of unknown function C48B4.12 C48B4.12 Protein of unknown function, has strong similarity to C. elegans F58A4.1 protein C48B4.2 C48B4.2 Member of the rhomboid family of integral membrane proteins Rhomboid C48B4.3 C48B4.3 Protein of unknown function C48B4.4 C48B4.4 Putative ortholog of C. elegans Y39D8C.1 gene product ATP-binding transport protein; The mutant phenotype of ced-7 is enhanced by mutation of ced-12. C48B4.6 C48B4.6 Protein of unknown function, has weak similarity to C. elegans C48B4.10 C48B4.7 C48B4.7 Protein of unknown function, has weak similarity to C. elegans C48B4.10 C48B4.8 C48B4.8 Protein of unknown function C48B4.9 C48B4.9 Protein of unknown function C48B6.10 C48B6.10 Protein of unknown function C48B6.2 C48B6.2 Protein with strong similarity to S. cerevisiae Imp3p, a component of U3 snoRNP that is required for pre-18S rRNA processing ribosomal protein C48B6.3 C48B6.3 Protein of unknown function C48B6.4 C48B6.4 Protein of unknown function C48B6.5 C48B6.5 Member of the C. elegans Srb family of receptor-like integral membrane proteins, has moderate similarity to uncharacterized C. elegans SRB-7 7TM chemoreceptor, srb family C48B6.6 smg-1;mab-1;C48B6.6 PI-3-related kinase involved in nonsense-mediated mRNA decay, mRNA surveillance kinase C48B6.8 C48B6.8 Protein of unknown function, has weak similarity to uncharacterized PTH-responsive osteosarcoma B1 (human B1) C48B6.9 C48B6.9 Protein of unknown function C48C5.1 C48C5.1 Member of the rhodopsin family of G protein-coupled receptors (GPCR), has low similarity to neuromedin U receptor 2 (human NMU2R), which is a G protein-coupled receptor that modulates intracellular calcium levels family 1 of G-protein coupled receptors C48C5.2 C48C5.2 Protein of unknown function C48C5.3 C48C5.3 Protein of unknown function, has low similarity to uncharacterized C. elegans C25B8.5 C48D1.1 C48D1.1 Protein with weak similarity to C. elegans ZYG-11, which is required for zygote formation C.elegans ZYG-11 like protein C48D1.2 ced-3;C48D1.2 Aspartate-specific cysteine protease; involved in induction of apoptosis; similar to mammalian interleukin-1-beta-converting enzyme Caspase recruitment domain, ICE-like protease (caspase) p20 domain., ICE-like protease (caspase) p10 domain.; The ced-3 gene encodes a protease required for apoptosis. C48D1.3 cho-1;C48D1.3 May be a high-affinity sodium-dependent choline transporter, and has similarity within the central region to human solute carriers SLC5A1, SLC5A5, and SLC5A2 (Hs.1964 , Hs.103983 , Hs.196878 ) choline transporter; cho-1 encodes a high-affinity choline transporter orthologous to members of the sodium-dependent glucose transporter family; CHO-1 is expressed in cholinergic neurons. C48D5.1 nhr-6;cnr8;ceb-1;C48D5.1 Member of the retinoic acid receptor (RAR) subfamily of thyroid hormone receptors, expressed in L3 and L4 larvae and in adults Zinc finger, C4 type (two domains) ; Ligand-binding domain of nuclear hormone receptors; nhr-6 encodes a nuclear receptor of the NR4A4 subfamily that is orthologous to the mammalian NGFI-B receptors and the Drosophila HR38 nuclear receptor (DHR38) that has been implicated in molting and metamorphosis; by homology, NHR-6 likely functions as a transcription factor that, based upon RNAi experiments, is required for normal ovulation and/or spermathecal development or function; an nhr-6 reporter fusion is expressed primarily in the anterior and posterior spermatheca during L3 and L4 larval stages, with some weak and variable expression also observed in two chemosensory neurons; nhr-6 mRNA is expressed in an oscillating manner throughout larval development, in a pattern that is slightly irregular with respect to the timing of larval molts and that exhibits consistently lower expression at the times when these molts actually occur. C48D5.2 ptp-1;nemPTP;C48D5.2 Member of the protein-tyrosine phosphatase family, contains two PDZ, DHR, or GLGF domains and a FERM domain (Band 4.1 family), which link proteins to membranes, has moderate similarity to protein tyrosine phosphatase non-receptor type 4 (human PTPN4) protein tyrosine phosphatase (non receptor type) and band 4.1-like domain; ptp-1 encodes a non-receptor tyrosine phosphatase containing Band 4.1 and PDZ domains that may function in linking cytoplasmic proteins and signaling molecules to sites on the plasma membrane; by homology, PTP-1 is predicted to function in cell signaling, but as loss of PTP-1 function via RNA-mediated interference (RNAi) does not result in any abnormalities, the precise role of PTP-1 in C. elegans development and/or behavior is not yet known. C48E7.1 C48E7.1 Protein of unknown function C48E7.10 C48E7.10 Protein of unknown function C48E7.2 C48E7.2 Protein with weak similarity to RNA polymerase III 62kD (human RPC62), which is a subunit of the RNA polymerase III subcomplex that functions in specific transcription initiation C48E7.3 C48E7.3 Protein containing a bZIP (basic-leucine zipper) transcription factor domain lpd-2 encodes a predicted transcription factor with homology to transcription factors of the CCAAT/Enhancer Binding Protein family (C/EBPA and B, OMIM:116897, 189965, associated with the regulation of mammalian adipocyte differentiation); in C. elegans, LPD-2 activity is required for normal lipid metabolism and wild-type levels of lipogenic enzyme expression, as well as for larval development; in addition, LPD-2 may be part of a conserved pathway regulating lipogenesis, as LPD-2 appears to positively regulate expression of sbp-1, which encodes the C. elegans Sterol Regulatory Element Binding Protein (SREBP) homolog, a basic helix-loop-helix-type transcription factor also required for normal lipid metabolism and larval development. C48E7.4 C48E7.4 Protein containing an olfactomedin-like domain, has low similarity to a region of myocilin (human MYOC), which is a structural protein found in the microtubule cytoskeleton that is associated with juvenile and adult-onset primary open-angle glaucoma C48E7.5 C48E7.5 Protein with weak similarity to C. elegans C34D4.15 gene product C48E7.6 C48E7.6 Protein with weak similarity to membrane-spanning chondroitin sulfate proteoglycan NG2 (rat Cspg4), which functions in cytoskeleton organization, cell proliferation, adhesion, migration, and melanoma metastasis C48E7.7 C48E7.7 Protein of unknown function, has very strong similarity to uncharacterized C. elegans T08B2.12 C48E7.8 C48E7.8 Member of the uncharacterized protein family UPF0063, has weak similarity to uncharacterized C. elegans F52F10.4 C48E7.9 C48E7.9 Protein of unknown function, has a region of low similarity to a region of potassium channel subfamily K member 3 (TASK-1, mouse Kcnk3), which forms an openly rectifying weakly voltage-sensitive channel that acts as a background cardiac K+ conductance C48G7.1 C48G7.1 Protein of unknown function C48G7.2 C48G7.2 Protein containing two Src homology 2 (SH2) domains, which are regulatory modules of intracellular signaling Src homology domain 2 C48G7.3 C48G7.3 Putative paralog of C. elegans Y50E8A.S C49A1.1 C49A1.1 Protein of unknown function, has weak similarity to C. elegans F33E2.5 C49A1.10 C49A1.10 Protein of unknown function C49A1.2 C49A1.2 Member of the C. elegans putative membrane protein family 8, has low similarity to a region of bestrophin (human VMD2), which plays a role in vision and is associated with Bests disease, adult vitelliform macular dystrophy, and bull's eye maculopathy Putative membrane protein C49A1.3 C49A1.3 Member of the C. elegans putative membrane protein family 8, has low similarity to a region of bestrophin (human VMD2), which plays a role in vision and is associated with Bests disease, adult vitelliform macular dystrophy, and bull's eye maculopathy Putative membrane protein C49A1.4 C49A1.4 Protein with strong similarity to human EYA2, Drosophila eyes absent homolog containing a phosphopantetheine attachment site Drosophila clift protein like; eya-1 encodes a protein orthologous to Drosophila EYES ABSENT (EYA), human EYA1, and human EYA4; the human genes EYA1 and EYA4, when mutated, lead to branchiootorenal dysplasia syndrome (BOR; OMIM:113650) and autosomal dominant nonsyndromic sensorineural (late-onset) deafness (DFNA10; OMIM:601316). C49A1.5 C49A1.5 Protein containing a DUF23 domain of unknown function, has strong similarity to uncharacterized C. elegans ZK381.2 C49A1.6 C49A1.6 Protein of unknown function, has moderate similarity to uncharacterized C. elegans K04H8.1 C49A1.8 C49A1.8 Member of the reverse transcriptase protein family, which are RNA-dependent DNA polymerases, has very strong similarity to uncharacterized C. elegans F22B3.3 reverse transcriptase C49A1.9 C49A1.9 Protein with strong similarity to C. elegans Y71A12D.f gene product C49A9.1 C49A9.1 Protein of unknown function, has low similarity to uncharacterized C. elegans C49A9.4 C49A9.2 C49A9.2 Protein of unknown function, has moderate similarity to uncharacterized C. elegans C49A9.3 C49A9.3 C49A9.3 Protein of unknown function, has moderate similarity to uncharacterized C. elegans C49A9.2 C49A9.4 C49A9.4 Protein of unknown function, has low similarity to uncharacterized C. elegans C49A9.1 C49A9.4 is orthologous to the human gene CYSTATIN B (STEFIN B) (CSTB; OMIM:601145), which when mutated leads to disease. C49A9.5 C49A9.5 Protein of unknown function, has high similarity to uncharacterized C. elegans C49A9.9 C49A9.6 C49A9.6 Protein of unknown function, has moderate similarity to uncharacterized C. elegans C49A9.9 C49A9.7 C49A9.7 Member of the rhodopsin family of G protein-coupled receptors (GPCR), has moderate similarity to tachykinin receptor 3 (rat Tacr3), which is a G protein-coupled receptor that may modulate behavior and sensory perception seven trans-smembrane receptor C49A9.8 C49A9.8 Protein containing a UDP-glucoronosyl and UDP-glucosyl transferase domain, which transfer glycosyl groups to small hydrophobic molecules, has weak similarity to UDP-glycosyltransferase 1 A9 (human UGT1A9), which alters xenobiotics to hydrophilic compounds UDP-glucuronosyltransferase C49A9.9 C49A9.9 Putative ortholog of C. elegans E02H9.3 gene product C49C3.1 C49C3.1 Member of the sodium:neurotransmitter symporter family, has low similarity to solute carrier family 6 member 9 (glycine transporter 1, human SLC6A9), which is a sodium and chloride-dependent glycine transporter Sodium:neurotransmitter symporter family (2 domains) C49C3.10 C49C3.10 Protein containing three protein kinase domains, has low similarity to jun N-terminal kinase 2 (human MAPK9), which regulates c-Jun (JUN) in response to proinflammatory cytokines or cellular stress and also triggers apoptosis serine/threonine kinase (2 domains) C49C3.11 C49C3.11 Protein with strong similarity to C. elegans C49C3.12 gene product C49C3.12 C49C3.12 Protein containing a C-type lectin domain, which mediate calcium-dependent carbohydrate recognition, has low similarity to uncharacterized C. elegans ZK39.3 Lectin C-type domain C49C3.13 C49C3.13 Protein containing a C-type lectin domain, which mediate calcium-dependent carbohydrate recognition, has moderate similarity to uncharacterized C. elegans C30H6.4 Lectin C-type domain C49C3.14 C49C3.14 Protein of unknown function, has weak similarity to C. elegans C30H6.3 C49C3.15 C49C3.15 Protein of unknown function C49C3.2 C49C3.2 Protein containing two protein kinase domains, has low similarity to a region of casein kinase 1 epsilon (mouse Csnk1e), which is a putative serine/threonine protein kinase with broad substrate specificity that may function in DNA repair serine/threonine kinase (2 domains) C49C3.3 C49C3.3 Protein of unknown function Ubiquitin family C49C3.4 C49C3.4 Putative ortholog of C. elegans T28F3.8 gene product EGF-like domain C49C3.5 C49C3.5 Protein containing a homeobox domain (homeodomain), which are found in transcription factors Homeobox domain C49C3.6 C49C3.6 Protein of unknown function, has high similarity to uncharacterized C. elegans C49C3.7 C49C3.7 C49C3.7 Protein of unknown function, has high similarity to uncharacterized C. elegans C49C3.6 C49C3.8 C49C3.8 Protein of unknown function C49C3.9 C49C3.9 Protein of unknown function C49C8.1 C49C8.1 Protein containing a protein kinase domain, has high similarity to uncharacterized C. elegans Y71F9AL.2 serine/threonine-protein kinase C49C8.2 C49C8.2 Protein of unknown function C49C8.3 C49C8.3 Protein of unknown function, has weak similarity to C. elegans T07G12.7 C49C8.4 C49C8.4 Member of the cytochrome P450 family, has low similarity to cytochrome P450 subfamily 2C polypeptide 8 (mephenytoin 4-hydroxylase, human CYP2C8), which is a heme-binding monooxygenase that metabolizes steroids, fatty acids, and xenobiotics cytochrome P450 C49C8.5 C49C8.5 Protein containing a beta or gamma fibrinogen C-terminal globular domain, has a region of low similarity to ficolin-2 (hucolin) (human FCN2), which is a predominantly liver calcium-dependent GlcNAc-binding collectin-like lectin C49C8.6 C49C8.6 Protein of unknown function C49D10.1 C49D10.1 Member of the reverse transcriptase family, which are RNA-dependent DNA polymerases, has strong similarity to uncharacterized C. elegans M01A10.4 reverse transcriptase C49D10.10 C49D10.10 Member of the protease protein family protease; C49D10.10 encodes a neprilysin; neprilysins are thermolysin-like zinc metallopeptidases, found on the outer surface of animal cells, that negatively regulate small signalling peptides (e.g., enkephalin, tachykinin, insulin, and natriuretic peptides) by cleaving them; C49D10.10 has no clear orthologs in other organisms. C49D10.11 C49D10.11 Protein with weak similarity to C. elegans W06D11.2 gene product C49D10.2 C49D10.2 Protein containing nuclear hormone receptor C4-type zinc finger and ligand-binding domains, has low similarity to C. elegans NHR-51, which is a putative transcriptional activator involved in developmental processses zinc finger protein C49D10.3 C49D10.3 Member of the 7-transmembrane chemoreceptor family of G protein-coupled receptors (GPCR), has high similarity to uncharacterized C. elegans T19C9.3 7TM chemoreceptor, srh family C49D10.4 C49D10.4 Protein with moderate similarity to C. elegans F41D3.4 gene product C49D10.5 C49D10.5 Protein containing two DUF33 domains of unknown function C49D10.6 nhr-75;C49D10.6 Member of the zinc finger protein family with similarity to nuclear hormone receptors zinc finger protein C49D10.7 C49D10.7 Protein containing three DUF33 domains of unknown function C49D10.8 C49D10.8 Protein containing a DUF33 domain of unknown function, has high similarity to uncharacterized C. elegans F37C4.3 C49D10.9 C49D10.9 Protein containing a nuclear hormone receptor C4-type zinc finger domain, which bind DNA and may be involved in regulation of transcription, has strong similarity to uncharacterized C. elegans C17A2.1 zinc finger protein C49F5.1 C49F5.1 Member of the s-adenosylmethionine synthetase protein family s-adenosylmethionine synthetase C49F5.2 C49F5.2 Protein containing a SET domain, which are involved in protein-protein interactions, has a region of weak similarity to a region of suppressor of variegation 3-9 homolog 2 (mouse Suv39h2), which is a histone methyltransferase modulating chromatin dynamics SET domain C49F5.3 C49F5.3 Protein of unknown function, has moderate similarity to uncharacterized C. elegans F02D10.6 C49F5.4 C49F5.4 Protein containing a nuclear hormone receptor ligand-binding domain, has low similarity to C. elegans NHR-51, which is involved in developmental processes Ligand-binding domain of nuclear hormone receptors, Zinc finger, C4 type (two domains) C49F5.5 C49F5.5 Protein containing a transcriptional adaptor putative zinc finger (TAZ) domain, which may bind transcriptional activators and repressors, has a region of moderate similarity to a region of C. elegans CBP-1, which is a transcriptional activator C49F5.6 C49F5.6 Protein with strong similarity to C. elegans F23D12.2 gene product C49F5.7 C49F5.7 Protein of unknown function, has weak similarity to C. elegans F23D12.1 C49F8.1 C49F8.1 Protein of unknown function C49F8.2 C49F8.2 Protein with moderate similarity to monocarboxylate transporters, has strong similarity to C. elegans T02G5.12, member of the major facilitator superfamily (MFS) monocarboxylate transporter like C49F8.3 C49F8.3 Protein containing a DB module domain C49G7.1 C49G7.1 Protein containing two ankyrin (Ank) repeats, which may mediate protein-protein interactions, and a BRCA1 (breast cancer type 1) C terminus (BRCT) domain, has high similarity to uncharacterized C. elegans K09D9.11 C49G7.10 C49G7.10 Protein of unknown function, has high similarity to uncharacterized C. elegans C49G7.7 C49G7.11 C49G7.11 Member of the ThiJ-PfpI family, has moderate similarity to RNA-binding protein regulatory subunit (human DJ-1), which is a putative oncogene that may regulate the androgen receptor and play a role in RAS protein signal transduction C49G7.2 C49G7.2 Member of the 7-transmembrane chemoreceptor family of G protein-coupled receptors (GPCR), has high similarity to uncharacterized C. elegans Y60A3A.6 7TM chemoreceptor, srh family C49G7.3 C49G7.3 Protein containing a DUF18 domain of unknown function, has very strong similarity to uncharacterized C. elegans C49G7.4 C49G7.4 C49G7.4 Protein containing a DUF18 domain of unknown function, has very strong similarity to uncharacterized C. elegans C49G7.3 C49G7.5 C49G7.5 Protein of unknown function, has high similarity to uncharacterized C. elegans C49G7.10 C49G7.6 C49G7.6 Protein of unknown function C49G7.7 C49G7.7 Protein containing a DUF141 domain of unknown function C49G7.8 C49G7.8 Member of the cytochrome P450 family, has low similarity to cytochrome P450 subfamily 2C polypeptide 8 (mephenytoin 4-hydroxylase, human CYP2C8), which is a heme-binding monooxygenase that metabolizes steroids, fatty acids, and xenobiotics cytochrome P450 C49G7.9 C49G7.9 Putative ortholog of C. elegans F52F10.1 gene product C49G9.1 C49G9.1 Protein of unknown function C49H3.1 gcy-8;C49H3.1 Protein containing an adenylate and guanylate cyclase catalytic domain, two receptor family ligand binding domains and two protein kinase domains, has low similarity to natriuretic peptide receptor B-guanylate cyclase B (human NPR2) receptor-type guanylyl cyclase; gcy-8 encodes a predicted transmembrane guanylyl cyclase that is expressed exclusively in the AFD thermosensory neurons; as loss of gcy-8 activity via RNA-mediated interference does not result in any abnormalities, the precise role of gcy-8 in C. elegans development and/or behavior is not yet known, however, expression in the AFD neurons suggests a possible role in thermotaxis; GCY-8 expression in the AFD neurons appears to be under the control of the paired-like homeodomain protein TTX-1 and the activity of the cyclic nucleotide gated channels TAX-2 and TAX-4. C49H3.10 C49H3.10 Protein with low similarity to exportin T (human XPOT), which is a transport receptor protein that interacts with and exports mature tRNAs from the nucleus in a RanGTP-dependent manner importin beta, nuclear transport factor; imb-6 encodes an importin-beta-like protein orthologous to vertebrate Exportin-t, a specific mediator of tRNA export from the nucleus; IMB-6 is predicted to function by binding tRNAs directly in the presence of the RAN-1 GTPase and facilitating their nucleocytoplasmic transport; in C. elegans, loss of imb-6 function via RNA-mediated interference (RNAi) does not result in any obvious abnormalities. C49H3.11 C49H3.11 Protein with high similarity to ribosomal protein S2 (S. cerevisiae Rps2p), which is a structural ribosomal protein, member of the ribosomal S5 family, which are part of the small ribosomal subunit rps-2 encodes a small ribosomal subunit S2 protein. C49H3.12 C49H3.12 Protein of unknown function C49H3.3 C49H3.3 Protein of unknown function C49H3.4 C49H3.4 Member of the Sm family, which are core constituents of snRNP complexes C49H3.5 C49H3.5 Protein containing an RNA recognition motif (RRM, RBD, or RNP), has a region of moderate similarity to a region of CCR4-NOT transcription complex subunit 4 (human CNOT4), which binds zinc and is likely to function in transcriptional repression zinc-finger transcription regulator; ntl-4 encodes two proteins by alternative splicing, one of which (NTL-4A) has an N-terminal RING finger and a RNA recognition motif ('RRM', 'RBD', or 'RNP'), and both of which have glutamine/asparagine-rich domains. C49H3.6 C49H3.6 Protein with weak similarity to C. elegans myo-3 gene product [A/Band-1/myosin/K12F2.1 Sarcomeric myosin heavy chain, minor component required for thick filaments in body-wall muscle] C49H3.8 C49H3.8 Member of the actin family, which are major cytoskeletal proteins actin-like protein C49H3.9 C49H3.9 Protein of unknown function C50A2.1 C50A2.1 Protein of unknown function C50A2.2 C50A2.2 Protein of unknown function, has weak similarity to C. elegans K06A5.1 C50A2.3 C50A2.3 Protein of unknown function C50A2.4 C50A2.4 Protein containing an ETS domain, which bind promoter DNA, has a region of moderate similarity to a region of mouse Elk1, which is a transcription factor and component of the Ternary Complex Factor (TCF) that binds to the Serum Response Element (SRE) C50B6.1 C50B6.1 Protein of unknown function C50B6.10 C50B6.10 Member of the 7-transmembrane chemoreceptor family of G protein-coupled receptors (GPCR), has low similarity to C. elegans ODR-10, which is involved in odorant response 7TM receptor C50B6.11 C50B6.11 Protein containing neurotransmitter-gated ion-channel ligand binding and transmembrane domains, has low similarity to alpha 3 subunit of the inhibitory glycine receptor (rat Glra3), which may play a role in neuronal differentiation and excitability neurotransmitter-gated ion channel C50B6.12 C50B6.12 Member of the 7-transmembrane chemoreceptor family of G protein-coupled receptors (GPCR), has low similarity to C. elegans ODR-10, which is involved in odorant response C50B6.2 C50B6.2 Protein with weak similarity to nuclear autoantigenic sperm protein (mouse Nasp), which is a histone binding and putative histone storage or transport protein that may play roles in the cell cycle and spermatogenesis histone binding protein C50B6.3 C50B6.3 Protein of unknown function C50B6.4 C50B6.4 Protein containing two collagen triple helix repeats, which are found in some extracellular proteins, and a nematode cuticle collagen N-terminal domain, has moderate similarity to a region of C. elegans BLI-1 collagen C50B6.5 C50B6.5 Protein of unknown function, has moderate similarity to uncharacterized C. elegans C02E7.2 C50B6.6 C50B6.6 Member of the 7-transmembrane chemoreceptor family of G protein-coupled receptors (GPCR), has low similarity to uncharacterized C. elegans R09F10.6 G-protein coupled receptor, srh family C50B6.7 C50B6.7 Protein with high similarity to alpha amylase (human AMY1A), which is a 1,4-alpha-D-glucan glucanohydrolase that degrades starch to glucose monomers, contains one alpha amylase C-terminal all-beta and one alpha amylase N-terminal catalytic domain amylase C50B6.8 C50B6.8 Protein containing three of both nuclear hormone receptor C4-type zinc finger and ligand-binding domains, has a region of weak similarity to pregnane X receptor (human NR1I2), which is a steroid activated nuclear hormone receptor Ligand-binding domain of nuclear hormone receptors, Zinc finger, C4 type (two domains) (2 domains) C50B6.9 C50B6.9 Protein of unknown function C50B8.1 C50B8.1 Protein containing an RNA recognition motif (RRM, RBD, or RNP), has low similarity to uncharacterized human DC50 RNA binding protein C50B8.2 bir-2;C50B8.2 Protein containing two baculoviral inhibitor of apoptosis protein repeat (BIR) domain, which are found in IAP (inhibitor of apoptosis) proteins, has a region of moderate similarity to C. elegans BIR-1, which is required for chromosome movement Inhibitor of Apoptosis domain.; The bir-2 gene encodes a protein with two BIR domains that may be involved in apoptosis. C50B8.3 C50B8.3 Protein of unknown function C50B8.4 C50B8.4 Protein of unknown function C50B8.5 C50B8.5 Protein of unknown function C50C10.1 C50C10.1 Protein containing a DUF215 domain of unknown function, has high similarity to uncharacterized C. elegans F46B6.11 C50C10.2 C50C10.2 Protein containing a DUF215 domain of unknown function, has high similarity to uncharacterized C. elegans C50C10.4 C50C10.3 C50C10.3 Protein containing a DUF215 domain of unknown function, has high similarity to uncharacterized C. elegans C50C10.2 C50C10.4 C50C10.4 Protein containing a DUF215 domain of unknown function, has high similarity to uncharacterized C. elegans C50C10.2 C50C10.5 C50C10.5 Protein containing a DUF215 domain of unknown function C50C10.6 C50C10.6 Member of the 7-transmembrane chemoreceptor family of G protein-coupled receptors (GPCR), has high similarity to uncharacterized C. elegans STR-2 C50C10.7 str-2;C50C10.7 Protein with predicted seven-transmembrane domain that has sequence similarity to diacetyl receptor ODR-10, expressed in either the left or right AWC odorant neurons as a result of a stochastic process C50C3.1 C50C3.1 Protein containing a CCCH-type zinc finger domain, which bind DNA or RNA C50C3.4 C50C3.2;C50C3.3;C50C3.4 Protein containing twelve spectrin repeats, which are involved in cytoskeletal structure, and two EF hand domains, which are found in signaling, buffering or transport proteins, has a region of weak similarity to a region of alpha actinin 2 (human ACTN2) C50C3.5 C50C3.5 Protein containing two EF hand domains, which are found in signaling, buffering or transport proteins Calmodulin C50C3.6 C50C3.6 Putative U5 snRNA-associated splicing factor PRP8, predicted to be involved in association of U5 snRNP with U4/U6 snRNP and to promote both catalytic steps of splicing prp-8 is orthologous to the human gene SIMILAR TO U5 SNRNP-SPECIFIC PROTEIN (220 KD), ORTHOLOG OF S. C50C3.7 C50C3.7 Protein containing an inositol polyphosphate phosphatase catalytic domain, which are (Mg2+)-dependent and (Li+)-sensitive, has weak similarity to human SKIP, which is an inositol polyphosphate 5-phosphatase Inositol polyphosphate-5-phosphatase C50C3.8 C50C3.8 Protein containing a meprin and TRAF homology (MATH) domain and a BTB (BR-C, ttk and babor) or POZ (Pox virus and zinc finger) domain, has weak similarity to C. elegans MEL-26, which is a negative regulator of the meiotic-spindle protein MEI-1 The C50C3.8 gene encodes a protein with a meprin-associated Traf homology (MATH) domain that may be involved in apoptosis. C50C3.9 unc-36;unc-72;C50C3.11;C50C3.9 Protein containing a von Willebrand factor (vWF) type A domain and a cache domain, which exist in animal channel subunits and bacterial chemotaxis receptors, has weak similarity to voltage-dependent calcium channel alpha 2/delta subunit 1 (human CACNA2D1) C50D2.1 C50D2.1 Putative ortholog of C. elegans E04F6.6 gene product C50D2.2 C50D2.2 Member of the amino acid permease family of membrane transporters, has moderate similarity to solute carrier family 7 member 4 (human SLC7A4), which mediates the uptake of cationic amino acids such as arginine amino acid permease C50D2.3 C50D2.3 Protein of unknown function, has weak similarity to C. elegans F40F9.3 C50D2.4 C50D2.4 Protein containing two collagen triple helix repeats, which are found in some extracellular proteins, and a nematode cuticle collagen N-terminal domain, has moderate similarity to a region of collagen type V alpha 2 subunit (human COL5A2) cuticular collagen C50D2.5 C50D2.5 Protein containing an RNA recognition motif (RRM, RBD, or RNP) C50D2.6 C50D2.6 Protein of unknown function, has weak similarity to C. elegans C50F4.8 C50D2.7 C50D2.7 Protein containing an acyl transferase domain This gene encodes a protein predicted by Eisenberg and coworkers, with 68% accuracy, to be mitochondrial. C50D2.8 C50D2.8 Protein with strong similarity to C. elegans Y119D3B.O gene product C50E10.1 C50E10.1 Protein with strong similarity to C. elegans Y57A10A.33 gene product C50E10.10 C50E10.10 Member of the C. elegans Sre G protein-coupled chemoreceptor family, which are putative chemosensory receptors, has moderate similarity to uncharacterized C. elegans F15A4.1 7TM chemoreceptor, sre family C50E10.11 C50E10.11 Member of the C. elegans Sre G protein-coupled chemoreceptor family, which are putative chemosensory receptors, has high similarity to uncharacterized C. elegans C50E10.8 7TM chemoreceptor, sre family C50E10.2 C50E10.2 Putative ortholog of C. elegans C25G4.8 gene product C50E10.3 C50E10.3 Member of the C. elegans Sre G protein-coupled chemoreceptor family, which are putative chemosensory receptors, has high similarity to uncharacterized C. elegans C50E10.7 7TM chemoreceptor, sre family C50E10.4 C50E10.4 Protein of unknown function, has weak similarity to human TGN51 and C. elegans K04C1.2 C50E10.5 C50E10.5 Member of the C. elegans Sre G protein-coupled chemoreceptor family, which are putative chemosensory receptors, has moderate similarity to uncharacterized C. elegans C50E10.8 7TM chemoreceptor, sre family C50E10.6 C50E10.6 Member of the C. elegans Sre G protein-coupled chemoreceptor family, which are putative chemosensory receptors, has high similarity to uncharacterized C. elegans C50E10.8 7TM chemoreceptor, sre family C50E10.7 C50E10.7 Member of the C. elegans Sre G protein-coupled chemoreceptor family, which are putative chemosensory receptors, has high similarity to uncharacterized C. elegans C50E10.8 7TM chemoreceptor, sre family C50E10.8 C50E10.8 Member of the C. elegans Sre G protein-coupled chemoreceptor family, which are putative chemosensory receptors, has high similarity to uncharacterized C. elegans C50E10.7 7TM chemoreceptor, sre family C50E10.9 C50E10.9 Member of the C. elegans Sre G protein-coupled chemoreceptor family, which are putative chemosensory receptors, has weak similarity to uncharacterized C. elegans Y57A10B.5 7TM chemoreceptor, sre family C50E3.1 C50E3.1 Protein of unknown function, has moderate similarity to uncharacterized C. elegans C50E3.3 C50E3.10 C50E3.10 Protein of unknown function, has high similarity to uncharacterized C. elegans T19C9.5 C50E3.11 C50E3.11 Member of the reduced folate carrier family, which transport reduced folate into cells, has low similarity to solute carrier family 19 member 1 (human SLC19A1), which is a reduced folate and thiamine transporter that also transports methotrexate folate transporter C50E3.12 C50E3.12 Protein of unknown function, has weak similarity to C. elegans C50E3.13, S. cerevisiae Ykl054p, and human KIAA0661 C50E3.13 C50E3.13 Protein of unknown function, has similarity to C. elegans C50E3.12 C50E3.2 C50E3.2 Protein with moderate similarity to C. elegans F08D12.4 gene product C50E3.3 C50E3.3 Protein of unknown function, has moderate similarity to uncharacterized C. elegans C50E3.1 C50E3.4 C50E3.4 Protein of unknown function C50E3.5 C50E3.5 Protein of unknown function C50E3.6 C50E3.6 Protein of unknown function C50E3.7 C50E3.7 Protein of unknown function, has high similarity to uncharacterized C. elegans Y75B8A.34 C50E3.8 C50E3.8 Protein with moderate similarity to C. elegans C50E3.7 gene product C50E3.9 C50E3.9 Protein of unknown function, has low similarity to uncharacterized C. elegans C50E3.7 C50F2.1 C50F2.1 Protein of unknown function, has a region of low similarity to a region of C. elegans ZYG-11, which is required for zygote formation C50F2.10 C50F2.10 Protein with strong similarity to C. elegans abf-2 gene product The abf-2 gene encodes an antimicrobial peptide that is homologous to antibacterial factor ASABF from Ascaris suum and closely related to ABF-1. C50F2.2 C50F2.2 Protein of unknown function, has a region of weak similarity to a region of heavy polypeptide of neurofilament (human NEFH), which is a structural protein of the cytoskeleton that likely regulates axonal caliber and synaptic transmission C50F2.3 C50F2.3 Putative pre-mRNA splicing factor, putative ortholog of S. cerevisiae Syf1p C50F2.4 C50F2.4 Protein of unknown function C50F2.5 C50F2.5 Member of the protein-tyrosine phosphatase family, which are involved in control of cell growth, proliferation, differentiation and transformation, has very strong similarity to uncharacterized C. elegans C43E11.5 C50F2.6 dao-8;C50F2.6 Member of the FK506-binding protein protein family peptidyl prolyl cis-trans isomerase; fkb-5 encodes a homolog of human FK506 binding protein 9. C50F2.7 C50F2.7 Protein of unknown function C50F2.8 C50F2.8 Protein containing a Src homology 3 (SH3) domain and a guanylate kinase domain, has a region of weak similarity to a region of C. elegans LIN-2, which is a component of the LIN-2, LIN-7, and LIN-10 cell junction complex involved in vulval development C50F2.9 C50F2.9 Protein with strong similarity to C. elegans abf-1 gene product The abf-1 gene encodes a homolog of the antibacterial factor ASABF from Ascaris suum; it is closely related to abf-2. C50F4.1 C50F4.1 Protein containing a DUF227 domain of unknown function C50F4.10 C50F4.10 Protein containing a protein kinase domain, has moderate similarity to uncharacterized C. elegans R13H9.5, which is a serine/threonine protein kinase serine/threonine kinase C50F4.11 mdf-1;C50F4.11 Coiled-coil protein with weak similarity to a family of D. melanogaster myosin heavy chains (see BLAST, see SMART), interacts with mdf-2 and is involved mitotic genome stability mdf-1 encodes a coiled-coil domain-containing protein that is orthologous to the Saccharomyces cerevisiae mitotic spindle checkpoint protein Mad1p; consistent with a role as a checkpoint protein, MDF-1 is required in C. elegans for mitotic genome stability and hence, long-term survival and fertility; in vitro, MDF-1 interacts with MDF-2, the C. elegans Mad2p ortholog, and with IFY-1, a Securin homolog; the maternal effect lethality produced by an mdf-1 mutation can be suppressed by a mutation in fzy-1, which encodes the C. elegans Cdc20 homolog. C50F4.12 C50F4.12 Protein of unknown function C50F4.13 his-35;C50F4.13 Protein with strong similarity to H2A histone family member X (human H2AFX), which is phosphorylated in response to DNA double-strand breaks in recombination, member of the histone family of nucleosomal core proteins histone H2A; his-35 encodes an H2A histone. C50F4.14 C50F4.14 Protein containing one uncharacterized domain DUF6, has weak similarity to C. elegans SQV-7, which is a multisubstrate nucleotide sugar transporter that affects chondroitin and heparan sulfate biosynthesis and has an important role in vulval invagination GDP-fucose transporter; The C50F4.14 gene encodes a putative GDP-fucose transporter orthologous to the human GDP-FUCOSE TRANSPORTER 1 gene (LAD II; OMIM:605881), which when mutated leads to congenital disorder of glycosylation, type IIc. C50F4.16 C50F4.16 Protein of unknown function The C50F4.16 gene encodes a NUDIX hydrolase. C50F4.2 C50F4.2 Member of the phosphofructokinase protein family 6-phosphofructokinase C50F4.3 C50F4.3 Member of the papain family of cysteine proteases, has low similarity to cathepsin H (rat Ctsh), which is a cysteine (thiol) protease that is involved in a variety of proteolytic processes and is inhibited by stefins A and B thiol protease C50F4.4 C50F4.4 Protein of unknown function C50F4.5 C50F4.5 Member of the histone H2B protein family histone H2B; his-41 encodes an H2B histone. C50F4.6 his-36;C50F4.6 Protein of unknown function his-36 encodes an UNSPECIFIED histone. C50F4.7 his-37;C50F4.7 Protein with very strong similarity to H4 histone family member E (human H4FE), which is a chromatin assembly complex component that may be involved in condensation of DNA into nucleosomes, member of the histone family of nucleosomal core proteins histone H4; his-37 encodes an H4 histone. C50F4.8 C50F4.8 Protein of unknown function, has weak similarity to C. elegans C50D2.6 C50F4.9 C50F4.9 Protein of unknown function C50F7.1 C50F7.1 Member of the rhodopsin family of G protein-coupled receptors (GPCR), has low similarity to tachykinin receptor 1 (substance P receptor, mouse Tacr1), which acts in pain transmission, inflammation, cell proliferation, and anxious and aggressive behavior G-protein coupled receptor C50F7.10 C50F7.10 Member of the glycosyl hydrolases family 1, which may be involved in carbohydrate metabolism, has low similarity to a region of lactase-phlorizin hydrolase (human LCT), which is a lactase and phloridzin hydrolase associated with adult type hypolactasia glycosyl hydrolase C50F7.2 C50F7.2 Protein of unknown function, has low similarity to a region of aggrecan 1 (large aggregating chondroitin sulfate proteoglycan, human AGC1), which is a component of cartilage clx-1 encodes a protein that contains 23 copies of a 15 amino acid repeat, possibly derived from a collagen triplet; there is no transcript evidence for this locus. C50F7.3 C50F7.3 Protein of unknown function, has low similarity to uncharacterized C. elegans H06H21.9 C50F7.4 scb2;C50F7.4 Member of the succinyl-CoA ligase, beta subunit protein family succinyl-CoA synthetase beta chain; This gene encodes a protein predicted by Eisenberg and coworkers, with 68% accuracy, to be mitochondrial. C50F7.5 C50F7.5 Protein of unknown function, has low similarity to a region of heavy polypeptide of neurofilament (mouse Nfh), which is a structural protein of the cytoskeleton that may regulates axonal caliber, synaptic transmission, and intermediate filament assembly C50F7.6 C50F7.6 Protein of unknown function C50F7.9 C50F7.9 Protein of unknown function, has weak similarity to C. elegans R09H10.2 C50H11.1 C50H11.1 Member of the AMP-binding enzyme family, has low similarity to S. cerevisiae Fat2p, which is a peroxisomal AMP-binding protein ATP-dependent AMP-binding protein C50H11.10 C50H11.10 Protein containing a DUF32 domain of unknown function, has high similarity to uncharacterized C. elegans R03H4.4 7TM chemoreceptor, srt family C50H11.11 C50H11.11 Protein containing a DUF32 domain of unknown function, has high similarity to uncharacterized C. elegans F48G7.6 7TM chemoreceptor, srt family C50H11.12 C50H11.12 Member of the 7-transmembrane chemoreceptor family of G protein-coupled receptors (GPCR), has weak similarity to C. elegans ODR-10, which is a G protein-coupled receptor involved in odorant response 7TM chemoreceptor, str family C50H11.13 C50H11.13 Protein of unknown function, has high similarity to uncharacterized C. elegans C54E10.3 C50H11.14 C50H11.14 Protein containing a DUF32 domain of unknown function, has high similarity to uncharacterized C. elegans C29G2.4 7TM chemoreceptor, srt family C50H11.15 C50H11.15 Member of the cytochrome P450 family, has moderate similarity to cytochrome P450 subfamily 2a polypeptide 4 (steroid 15-alpha-hydroxylase, mouse Cyp2a4), which is a liver enzyme that catalyzes the hydroxylation of testosterone and estradiol cytochrome P450 C50H11.17 C50H11.17 Protein of unknown function, has high similarity to uncharacterized C. elegans Y73C8C.4 C50H11.2 C50H11.2 Protein containing a DUF32 domain of unknown function, has high similarity to uncharacterized C. elegans C50H11.4 7TM chemoreceptor, srt family C50H11.3 C50H11.3 Protein containing a DUF32 domain of unknown function, has moderate similarity to uncharacterized C. elegans C50H11.4 7TM chemoreceptor, srt family C50H11.4 C50H11.4 Protein containing a DUF32 domain of unknown function, has high similarity to uncharacterized C. elegans R13D7.10 7TM chemoreceptor, srt family C50H11.5 C50H11.5 Protein containing a DUF32 domain of unknown function, has high similarity to uncharacterized C. elegans C50H11.4 7TM chemoreceptor, srt family C50H11.6 C50H11.6 Protein containing a DUF32 domain of unknown function, has high similarity to uncharacterized C. elegans C50H11.5 C50H11.7 C50H11.7 Member of the 7-transmembrane chemoreceptor family of G protein-coupled receptors (GPCR), has low similarity to uncharacterized C. elegans R03H4.9 7TM chemoreceptor, srh family C50H11.8 C50H11.8 Protein of unknown function, has weak similarity to C. elegans H35N09.1 C50H11.9 str-244;C50H11.9 Member of the 7-transmembrane chemoreceptor family of G protein-coupled receptors (GPCR), has high similarity to uncharacterized C. elegans K02H11.7 7TM chemoreceptor, str family C50H2.1 C50H2.1;CeLGR;LGR Member of the leucine-rich repeat-containing, G protein-coupled receptors, LGR, protein family steroid hormone receptor; C50H2.1 is orthologous to the human gene FORKHEAD BOX O1A (RHABDOMYOSARCOMA) (FSHR; OMIM:136533), which when mutated leads to disease. C50H2.10 C50H2.10 Protein of unknown function C50H2.11 C50H2.11 Protein of unknown function C50H2.2 C50H2.2 Protein of unknown function The egl-47 gene encodes a G protein-coupled receptor required for proper function, but not morphology or structure, of the hermaphrodite-specific motor neurons (HSNs) that control egg laying; EGL-47 is expressed in the HSNs and appears to localize at synapses made in the egg-laying system; EGL-47 may interact with GOA-1, a G protein that blocks egg laying. C50H2.3 mec-9;C50H2.3 Protein with EGF-like repeats that is required for touch sensation mechanosensory protein (mec-9); mec-9 encodes a predicted extracellular protein containing six EGF-like repeats,five Kunitz-type protease inhibitor domains, and a glutamic acid-rich region possibly involved in protein-protein interactions; mec-9 encodes two proteins, only one of which, MEC-9L, appears to be required for normal mechanosensory response to gentle touch and proper functioning of the touch receptor neurons; mec-9 interacts genetically with mec-5, which encodes a unique C. elegans collagen secreted by the hypodermis; MEC-9L is expressed and secreted by the touch receptor neurons. C50H2.4 C50H2.4 Protein of unknown function, has moderate similarity to uncharacterized C. elegans C50H2.5 C50H2.5 C50H2.5 Protein of unknown function, has moderate similarity to uncharacterized C. elegans C50H2.4 C50H2.6 C50H2.6 Protein of unknown function C50H2.7 C50H2.7 Protein of unknown function, has low similarity to uncharacterized C. elegans C26E6.1 C51E3.1 C51E3.1 Protein of unknown function, has high similarity to uncharacterized C. elegans C51E3.2, which is a G protein-coupled receptor olfactory receptor C51E3.2 C51E3.2 Member of the rhodopsin family of G protein-coupled receptors (GPCR), has high similarity to uncharacterized C. elegans C51E3.3 opoid receptor C51E3.3 C51E3.3 Protein of unknown function, has high similarity to uncharacterized C. elegans C51E3.2, which is a putative G protein-coupled receptor (GPCR) somatostatin receptor C51E3.4 C51E3.4 Member of the rhodopsin family of G protein-coupled receptors (GPCR), has high similarity to uncharacterized C. elegans C51E3.3 7TM receptor C51E3.5 C51E3.5 Protein with moderate similarity to C. elegans C51E3.4 gene product olfactory receptor C51E3.6 C51E3.6 Member of the nucleobase transporter protein family Mouse YSPL-1 protein like C51E3.7 egl-3;Cepc2;kpc-2;C51E3.7 Proprotein convertase; processes prohormones and proneuropeptides by endoproteolytic cleavage; similar to Kex2-like serine endoproteases prohormone convertase 2; The egl-3 gene encodes a homolog of a mammalian proprotein convertase that participates in peptide secretion. C51E3.8 C51E3.8 Putative ortholog of C. elegans C08B6.4 gene product chitinase C51F7.1 C51F7.1 Protein of unknown function, has a region of weak similarity to a region of protein tyrosine phosphatase non-receptor type 13 (mouse Ptpn13), which may have a role in differentiation processes and in cytoskeletal regulation of the developing nervous sytem C51F7.2 C51F7.2 Protein of unknown function, has high similarity to uncharacterized C. elegans F31E9.2 C51G7.J Y56A3A.33;C51G7.J Member of the exonuclease family, has a region of low similarity to a region of ribonuclease H (70 kDa) (S. cerevisiae Rnh70p), which is an endonuclease that degrades RNA in RNA-DNA hybrids C52A10.1 C52A10.1 Member of the carboxylesterase protein family carboxylesterase C52A10.2 C52A10.2 Member of the carboxylesterase protein family carboxylesterase C52A10.3 C52A10.3 Protein containing an F-box domain, which serve as a link between a target protein and a ubiquitin-conjugating enzyme, has low similarity to uncharacterized C. elegans Y39A1A.16 C52A11.2 C52A11.2 Protein of unknown function Globin C52A11.3 C52A11.3 Member of the PDZ domain (also known as DHR Or GLGF) protein family PDZ domain (Also known as DHR or GLGF). C52A11.4 C52A11.4 Protein with strong similarity to Drosophila Discs lost and human multiple PDZ domain protein (MPDZ); contains 8 lethal[1] discs large-1 tumor suppressor protein-like repeats lethal(1) discs large-1 tumor suppressor protein-like repeats C52B11.2 C52B11.2 Protein containing a K+ channel tetramerization domain, which facilitate assembly of alpha-subunits into functional tetrameric channels, has high similarity to uncharacterized human FLJ20040 potassium channel protein C52B11.3 C52B11.3 Member of the rhodopsin family of G protein-coupled receptors (GPCR), has low similarity to adrenergic receptor alpha 2b (mouse Adra2b), which binds epinephrine and norepinephrine and signals through adenylyl cyclase G-protein coupled receptor C52B11.4 C52B11.4 Protein with weak similarity to C. elegans Y40H7A.7 gene product C52B11.5 C52B11.5 Protein of unknown function, has a region of low similarity to Ras-related GTP-binding protein 5 (rat Rab5a), which regulates endocytic transport RAS-related proteins (weak) C52B9.1 C52B9.1 Member of the choline or ethanolamine kinase family, which catalyze the formation of phosphatidylcholine by the CDP-choline pathway, has moderate similarity to choline-ethanolamine kinase (rat Chkl), which is involved in phosphatidylcholine biosynthesis choline kinase C52B9.10 C52B9.10 Protein of unknown function C52B9.2 C52B9.2 Protein containing three ETS domains, which bind promoter DNA C52B9.3 C52B9.3 Protein with weak similarity to C. elegans K07H8.1 gene product C52B9.4 C52B9.4 Protein of unknown function C52B9.5 C52B9.5 Putative ortholog of C. elegans F48D6.2 gene product 7TM chemoreceptor, srv family C52B9.6 C52B9.6 Member of the ion transport family, which include calcium, sodium, and potassium channels, has a region of low similarity to a region of potassium channel subfamily K member 3 (TASK-1, human KCNK3) C52B9.7 paf-2;C52B9.7 Putative acetylhydrolase, has similarity to human platelet-activating factor acetylhydrolases PAFAH and PAFAH2 paf-2 encodes a homolog of vertebrate Type II Platelet-activating factor-acetylhydrolase (PAF-AH) that is 70% identical to PAF-2 that is required for embryogenesis and affects organization of the hypodermis. C52B9.8 C52B9.8 Protein with high similarity to C. elegans PSA-4, which is a putative component of a SWI/SNF chromatin remodeling complex and is active in the control of mitosis, contains a helicase conserved C-terminal domain and an SNF2 related N-terminal domain helicase C52B9.9 mec-18;C52B9.9 Member of the AMP-binding enzyme family, has weak similarity to S. cerevisiae Acs1p, which is acetyl-CoA synthetase (acetate-CoA ligase) AMP-binding protein; mec-18 encodes a protein similar to firefly luciferase and plant protein 4-coumarate coA ligase; mec-18 is involved in sensory mechanotransduction; genetic interactions with other mec genes suggest that mec-18 maybe involved in negative regulation of the degenerin channel in the touch receptor neurons; mec-18 is expressed exclusively in the touch cells. C52D10.1 C52D10.1 Protein with strong similarity to C. elegans ZK1055.7 gene product C52D10.11 C52D10.11 Putative FMRF-amide neurotransmitter, has similarity to C. elegans FLP-8 C52D10.12 C52D10.12 Protein containing a DUF21 domain of unknown function, has a region of low similarity to a region of S. cerevisiae Ami3p, which is required for normal mitochondrial structure C52D10.12 encodes a homolog of human ACDP1-ACDP4 and a paralog of C01H6.6, C33D12.2, M02F4.3, R04E5.2, and R13G10.4; both C52D10.12 and ACDP1-ACDP4 belong to a family of proteins (defined by NCBI as KOG2118) that are predicted to be membrane-spanning and that share a motif (the 'ACD domain') with proteins from bacteria, yeast, plants, and metazoa; murine Acdp1 is a plasma membrane protein bacterial proteins containing the ACD domain include CorC from Salmonella typhimurium, which is involved in magnesium and cobalt efflux; C52D10.12 has no obvious function in RNAi assays. C52D10.13 C52D10.13 Protein containing two collagen triple helix repeats, which are found in some extracellular proteins, and a nematode cuticle collagen N-terminal domain, has a region of moderate similarity to a region of collagen type V alpha 3 subunit (human COL5A3) cuticular collagen C52D10.2 C52D10.2 Protein with moderate similarity to C. elegans ZK1055.6 gene product C52D10.3 C52D10.3 Protein of unknown function C52D10.5 C52D10.5 Member of the transposase protein family C52D10.6 skr-12;C52D10.6 Member of the Skp1 family, which are required for targeted protein degradation during the cell cycle, has a region of moderate similarity to a region of S. cerevisiae Skp1p, which is a component of Cbf3 kinetochore and SCF (Skp1p-cullin-F-box) complexes cyclin A-associated protein; skr-12 encodes a homolog of Skp1 in S. cerevisiae, a core component of the SCF (Skp1p, Cullin, F-box) ubiquitin-ligase complex that facilitates ubiquitin-mediated protein degradation; SKR-12 has no known function in vivo, since skr-12(RNAi) animals are at least superficially normal. C52D10.7 skr-9;C52D10.7 Member of the Skp1 family, which are required for targeted protein degradation during the cell cycle, has a region of moderate similarity to a region of S. cerevisiae Skp1p, which is a component of Cbf3 kinetochore and SCF (Skp1p-cullin-F-box) complexes cyclin A-associated protein; skr-9 encodes a homolog of Skp1 in S. cerevisiae, a component of the SCF (Skp1, Cullin, F-box) ubiquitin-ligase complex that regulates ubiquitin-mediated protein degradation; SKR-9 is required for posterior body morphogenesis, embryonic and larval development, and postembryonic cell proliferation. C52D10.8 skr-13;C52D10.8 Member of the Skp1 family, which are required for targeted protein degradation during the cell cycle, has a region of moderate similarity to a region of S. cerevisiae Skp1p, which is a component of Cbf3 kinetochore and SCF (Skp1p-cullin-F-box) complexes cyclin A-associated protein; The skr-13 gene encodes a homolog of Skp1 in S. cerevisiae that has no known function in vivo, since skr-13(RNAi) animals are at least superficially normal. C52D10.9 skr-8;C52D10.9 Member of the Skp1 family, which are required for targeted protein degradation during the cell cycle, has a region of moderate similarity to a region of S. cerevisiae Skp1p, which is a component of Cbf3 kinetochore and SCF (Skp1p-cullin-F-box) complexes cyclin A-associated protein; skr-8 encodes a homolog of Skp1 in S. cerevisiae, a component of the SCF (Skp1, Cullin, F-box) ubiquitin-ligase complex that regulates ubiquitin-mediated protein degradation; SKR-8 is required for is required for posterior body morphogenesis, embryonic and larval development, and cell proliferation; SKR-8 can interact with CUL-1, a C. elegans cullin homolog. C52E12.1 C52E12.1 Protein containing nine C2H2 type zinc finger domains, which bind nucleic acids, has a region of low similarity to a region of KRAB zinc finger protein (mouse Mzf22), which functions as a transcriptional repressor via interactions with mouse Trim28 zinc-finger containing protein C52E12.2 unc-104;klp-1;C52E12.2 Plus-end directed motor kinesin required for axonal transport of synaptic vesicles to synaptic regions kinesin-like protein; The unc-104 gene encodes a kinesin-like motor protein homologous to human axonal transporter of synaptic vesicles (ATSV, OMIM: 601255), and is required for anterograde axonal transport of synaptic vesicles as well as differentiation of pre- and postsynaptic domains at inhibitory neuromuscular junctions; UNC-104 is expressed solely in neurons. C52E12.3 sqv-7;C52E12.3 Multisubstrate nucleotide sugar transporter, with effects on chondroitin and heparan sulfate biosynthesis; has important roles in vulval invagination The sqv-7 gene encodes a nucleotide-sugar transporter of the Golgi membrane, that is required for cytokinesis of one-cell embryos and for vulval morphogenesis; SQV-7 promotes glycosaminoglycan biosynthesis by translocating UDP-glucuronic acid, UDP-N-acetylgalactosamine, and UDP-galactose into the lumen of the Golgi apparatus; SQV-7 is biochemically active when transgenically expressed in yeast or mammalian Golgi membranes; the common requirement for SQV-7 in both cytokinesis and morphogenesis may be to promote filling an extracellular space with hygroscopic proteoglycans (either in the eggshell, or underneath the L4 cuticle), which in turn may cause the space to fill with fluid. C52E12.4 C52E12.4 Protein containing two RUN domains, two DENN (AEX-3) domains, and two PLAT (Polycystin-1, Lipoxygenase, Alpha-Toxin) or LH2 (Lipoxygenase homology) domains, has low similarity to rab6 interacting protein 1 (mouse Rab6ip1) C52E2.1 C52E2.1 Putative ortholog of C. elegans C52E2.I gene product This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins; this gene's encoded protein also contains an FTH/DUF38 motif, which may also mediate protein-protein interaction. C52E2.2 C52E2.2 Protein with moderate similarity to C. elegans C52E2.H gene product C52E2.3 C52E2.3 Putative ortholog of C. elegans ZK250.2 gene product C52E2.4 C52E2.4 Putative ortholog of C. elegans C52E2.E gene product C52E2.5 C52E2.5 Putative ortholog of C. elegans ZK250.5 gene product C52E2.6 C52E2.6 Putative ortholog of C. elegans C52E2.B gene product C52E2.7 C52E2.7 Putative ortholog of C. elegans C52E2.B gene product C52E2.8 C52E2.8 Putative ortholog of C. elegans C52E2.A gene product C52E4.1 gcp-1;cpr-1;C52E4.1 Cysteine protease expressed in the intestine cathepsin-like cysteine protease; cpr-1 encodes a cysteine protease of the cathepsin B-like cysteine protease family; cpr-1 appears to be required for embryogenesis; cpr-1 is specifically expressed in the gut of all stages except the embryo and around developing embryos in the gonad; expression of cpr-1 is regulated by three promoter GATA motifs. C52E4.2 mif-2;C52E4.2 Member of the macrophage migration inhibitory factor family, has moderate similarity to D-dopachrome tautomerase (human DDT), which is a melanoma tumor antigen and zinc metalloenzyme that catalyzes conversion of D-dopachrome to 5,6-dihydroxyindole macrophage migration inhibitory factor like protein C52E4.3 C52E4.3 Protein with strong similarity to small nuclear ribonucleoprotein D2 polypeptide (human SNRPD2), which is involved in snRNP biogenesis and pre-mRNA splicing, member of the Sm family, which are core constituents of snRNP complexes small nuclear ribonucleoprotein D2 like C52E4.4 rpt-1;C52E4.4 Putative ATPase subunit of 19S proteasome particle 26S protease regulatory subunit 7; rpt-1 encodes a predicted ATPase subunit of the 19S regulatory complex of the proteasome that affects fertility and embryonic viability. C52E4.5 C52E4.5 Protein with high similarity to mannosidase 1 alpha (mouse Man1a), which trims mannose residues and plays a role in misfolded protein degradation, member of the glycosyl hydrolase 47 family of alpha-mannosidases, which hydrolyze terminal mannose residues alpha 1,2, mannosidase C52E4.6 C52E4.6 Protein containing two cyclin N-terminal domains, has a region of low similarity to S. pombe Pch1p, which is protein kinase likely to be involved in cell cycle progression C52E4.7 C52E4.7 Protein with moderate similarity to C. elegans F53B6.7 gene product C52G5.1 C52G5.1 Protein of unknown function C52G5.2 C52G5.2 Protein of unknown function, has low similarity to uncharacterized human LOC51078 C53A3.1 C53A3.1 Protein containing an F-box domain, which serve as a link between a target protein and a ubiquitin-conjugating enzyme, has low similarity to uncharacterized C. elegans Y39A1A.16 This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins. C53A3.2 C53A3.2 Member of the haloacid dehalogenase or epoxide hydrolase family, has low similarity to S. pombe Pho2p, which is a specific p-nitrophenylphosphatase C53A5.1 C53A5.1 Protein of unknown function C53A5.10 C53A5.10 Protein containing a DUF32 domain of unknown function, has high similarity to uncharacterized C. elegans F54E2.6 C53A5.11 C53A5.11 Protein containing four Kelch motif domains, has a region of low similarity to a region of intracisternal A particle-promoted protein (human IPP), which is an actin-binding protein that plays a role in cell shape and cell size ring canal protein like C53A5.12 gar-3;C53A5.12 Muscarinic acetylcholine receptor, member of the G protein-coupled receptor protein family C53A5.13 C53A5.13 Protein containing a fibronectin type III domain, which are involved in cell surface binding, has low similarity to a region of C. elegans LET-805, which is a putative cell adhesion protein required for movement and elongation during embryogenesis C53A5.2 C53A5.2 Member of the Met-10+-like protein family, which may be involved in methionine biosynthesis, transport or utilization Neurospora met-10 protein like C53A5.3 hda-1;C53A5.3 Histone deacetylase Yeast RPD3 protein like; The hda-1 gene encodes a histone deacetylase 1, similar to histone deacetylases RPD3 from yeast and fly; maternal and zygotic expression of hda-1 is required for embryonic viability, and zygotic expression of hda-1 is also required for gonadogenesis and vulval development. C53A5.4 C53A5.4 Protein containing a protein kinase domain, has low similarity to casein kinase 1 gamma 1 (rat Csnk1g1), which is a serine/threonine protein kinase that may play roles in cell growth and in morphogenesis serine/threonine kinase C53A5.5 C53A5.5 Protein containing a calmodulin binding domain, which form an elongated dimer with calmodulin bound at each end, has low similarity to small conductance calcium-activated potassium channel 1 (rat Kcnn1), which may regulate neuronal membrane excitability calcium-activated potassium channel C53A5.6 C53A5.6 Protein containing a C3HC4 type (RING) zinc finger domain and five Kelch motif domains, has a region of low similarity to a region of intracisternal A particle-promoted protein (human IPP), which plays a role in determining cell size and shape Zinc finger, C3HC4 type (RING finger) C53A5.8 C53A5.8 Protein of unknown function, has low similarity to uncharacterized C. elegans R05D8.6 G-protein coupled receptor, srg family C53A5.9 C53A5.9 Protein containing five Kelch motif domains and a cyclin C-terminal domain, which often form complexes with protein kinases and cyclin dependent protein kinases, has low similarity to intracisternal A particle-promoted protein (human IPP) ring canal protein like C53B4.1 C53B4.1 Member of the sugar (and other) transporter family, has weak similarity to human SLC22A1, which is an organic cation transporter that mediates the elimination of diverse endogenous amines and xenobiotics transport protein C53B4.2 C53B4.2 Protein of unknown function, has low similarity to uncharacterized C. elegans C45G9.8 C53B4.3 C53B4.3 Member of the sugar (and other) transporter family, has low similarity to uncharacterized solute carrier family 22 member 1-like (mouse Slc22a1l), which is a putative transporter that is highly expressed in intestine, kidney, liver and placenta C53B4.3 is orthologous to the human gene UNKNOWN (PROTEIN FOR MGC:23098) (SLC22A1L; OMIM:602631), which when mutated leads to disease. C53B4.4 C53B4.4 Protein containing three phorbol esters or diacylglycerol binding domains (C1 domain), which bind two zinc ions, and three PDZ, DHR, or GLGF domains, which are found in signaling proteins PDZ domain (Also known as DHR or GLGF). ; Phorbol esters/diacylglycerol binding domain (C1 domain) C53B4.5 C53B4.5 Protein with high similarity to C. elegans SQT-3, contains two collagen triple helix repeats, which are found in some extracellular proteins, and a nematode cuticle collagen N-terminal domain collagen C53B4.6 C53B4.6 Member of the YEA4-like protein family, has similarity to the Golgi membrane UDP-GlcNAc transporter of K. lactis Yeast YEA4 like protein C53B4.7 C53B4.7 Protein with high similarity to GDP-mannose-4,6-dehydratase (human GMDS), which is an epimerase that converts GDP-mannose to GDP-mannose-4-keto-6-D-deoxymannose and plays a role in the synthesis of fucosylated oligosaccharides C53B7.1 C53B7.1 Putative member of Immunoglobulin superfamily C53B7.2 C53B7.2 Protein containing a trypsin inhibitor-like cysteine rich domain C53B7.3 C53B7.3 Protein with moderate similarity to C. elegans D1044.7 gene product C53B7.4 C53B7.4 Protein of unknown function, has high similarity to uncharacterized C. elegans K07A12.3 ATP synthase; asg-1 encodes a homolog of ATP synthase G required both for growth at a normally high rate and for normal osmoregulation. C53B7.5 odr-10;C53B7.5 G protein-coupled receptor involved in odorant response, member of large family of putative odorant response proteins, no homolog found in human or D. melanogaster chemoreceptor; The odr-10 gene encodes a member of the 7-transmembrane family of odorant receptors which affects chemotaxis to the volatile odorant diacetyl; it is expressed in two AWA neurons and, at low levels, in the CEP neurons. C53B7.6 C53B7.6 Protein of unknown function, has strong similarity to uncharacterized C. elegans T11F9.14 C53B7.7 C53B7.7 Protein of unknown function, has similarity to C. elegans F40B5.1 C53B7.7 encodes a neprilysin; neprilysins are thermolysin-like zinc metallopeptidases, found on the outer surface of animal cells, that negatively regulate small signalling peptides (e.g., enkephalin, tachykinin, insulin, and natriuretic peptides) by cleaving them; C53B7.7 has no clear orthologs in other organisms. C53C11.1 C53C11.1 Protein of unknown function C53C11.2 C53C11.2 Protein of unknown function C53C11.3 ptr-5;C53C11.3 Putative paralog of C. elegans C41D7.2, has strong similarity to a number of C. elegans proteins and may be related to H. sapiens NPC1, which is involved in Niemann-Pick disease, type C1 C53C11.4 C53C11.4 Protein of unknown function, has high similarity to uncharacterized C. elegans Y54B9A.1 S. muris microneme antigen C53C7.1 C53C7.1 Member of the rhodopsin family of G protein-coupled receptors (GPCR), has low similarity to G protein-coupled receptor 10 (human GPR10), which binds a peptide which stimulates prolactin (human PRL) secretion 7 transmembrane receptor (rhodopsin family) C53C7.2 C53C7.2 Protein of unknown function C53C7.3 C53C7.3 Protein of unknown function C53C9.1 nShab1;C53C9.1 Member of the voltage-gated potassium channel protein family potassium channel protein C53C9.2 C53C9.2 Protein containing six calponin family repeats, which consist of a well conserved 26 amino acid domain, has a region of moderate similarity to a region of C. elegans UNC-87, which is an actin-bundling protein associated with muscle thin filaments C53C9.3 C53C9.3 Protein with high similarity to C. elegans EXP-2, which is an inward rectifying pharyngeal K-type (voltage activated) potassium channel, member of the ion transport family, contains a K+ channel tetramerization domain C53D5.1 C53D5.1 Protein of unknown function, putative paralog of C. elegans C53D5_1638.H C53D5.2 C53D5.2 Protein of unknown function, has strong similarity to C. elegans C53D5_1638.G C53D5.3 C53D5_1638.F;C53D5.F;C53D5.3 Protein of unknown function C53D5.4 C53D5.4 Putative paralog of C. elegans C53D5_1638.D zinc finger protein C53D5.5 C53D5.5 Putative paralog of C. elegans H14N18.4 (Member of the gamma-glutamyltransferase (tentative) protein family) gamma-glutamyltranspeptidase; The C53D5.5 gene encodes an ortholog of the human gene GAMMA-GLUTAMYLTRANSFERASE 1 (GGT1), which when mutated leads to glutathionuria (OMIM:231950). C53D5.6 C53D5_1638.A;C53D5.A;C53D5.6 Protein with moderate similarity to karyopherin beta 3 (human KPNB3), which is a subunit of the nuclear localization signal receptor complex and plays a role in nuclear import of ribosomal proteins importin beta, nuclear transport factor; imb-3 encodes an importin-beta-like protein orthologous to Drosophila, vertebrate, and yeast importin/karyopherin-beta3; IMB-3 is predicted to function as a nuclear transport factor that, with the RAN-1 GTPase, regulates nuclear import of ribosomal proteins; in C. elegans, IMB-3 is essential for embryogenesis and germline development, and may also be required for normal postembryonic growth rates. C53D6.1 C53B4.8;C53D6.1 Protein of unknown function, has low similarity to uncharacterized C. elegans F19H8.4 C53D6.2 unc-129;C53D6.2 Member of the transforming growth factor-beta (TGF-beta) superfamily of secreted signaling molecules; involved in axon guidance bone morphogenetic protein like; The unc-129 gene encodes a member of the TGF-beta family of secreted growth factor signaling molecules; UNC-129 is required for proper axonal guidance of commissural motorneurons and for proper migration of the distal tip cells of the somatic gonad; UNC-129 is expressed in dorsal body wall muscle and at present does not appear to act through the known TGF-beta type I and II receptors. C53D6.3 C53D6.3 Protein containing neurotransmitter-gated ion-channel ligand binding and transmembrane domains, has moderate similarity to C. elegans MOD-1, which is a serotonin-gated chloride channel ligand-gated ion channel C53D6.4 C53D6.4 Member of the rhodopsin family of G protein-coupled receptors (GPCR) angiotensin receptor like C53D6.5 C53D6.5 Protein of unknown function C53D6.6 C53D6.6 Protein of unknown function, has weak similarity to uncharacterized C. elegans K09A11.1 C53D6.7 C53D6.7 Member of the galectin family, has a region of low similarity to galectin (C. elegans LEC-1), which is a galactoside-binding lectin galactoside-binding lectin like C53H9.2 C53H9.2 Member of an uncharacterized GTPase family, has moderate similarity to S. cerevisiae Lsg1p, which is a protein required for normal growth, morphology,mating, and sporulation C53H9.2 encodes at least three protein isoforms orthologous to the GTP-binding proteins human GNL1 (HSR1; OMIM:143024) and murine MMR1, as well as LSG1 in S. cerevisiae and many other eukaryotic and bacterial proteins; one alternative transcription unit of the C53H9.2 locus, C53H9.2a, has a natural nonsense transcript that is up-regulated in vivo by smg[-] mutations, indicating that C53H9.2 is a natural substrate for SMG-mediated nonsense suppresssion; C53H9.2 is required in mass RNAi assays for embryonic viability, normally rapid growth, and early embryonic nuclear positioning; since several other natural mRNA substrates of SMG suppression (e.g., rpl-3, rpl-8, rpl-10a, rpl-12) have protein products that are involved in translation, C53H9.2's protein products may function in translation as well, an inference supported by the observed role of LSG1 in cytoplasmic 60S ribosomal subunit biogenesis. C54A12.1 ptr-6;C54A12.1 Has strong similarity to several C. elegans proteins that may be related to H. sapiens NPC1 (involved in Niemann-Pick disease) C54A12.2 C54A12.2 Member of the rhodopsin family of G protein-coupled receptors (GPCR), has high similarity to uncharacterized C. elegans R12C12.3 C54A12.3 C54A12.3 Protein of unknown function C54A12.4 C54A12.4 Member of the Ras superfamily of GTP-binding proteins, has moderate similarity to ras homolog gene family member I (aplysia ras homolog I) (human ARHI), which negatively regulates cell growth and likely acts as a tumor suppressor RAS-related protein C54C6.1 rpl-37;C54C6.1 Member of the ribosomal protein L37 protein family 60S ribosomal protein L37; rpl-37 encodes a large ribosomal subunit L37 protein. C54C6.2 ben-1;C54C6.2 Beta tubulin tubulin; A beta-tubulin that confers benzimidazole sensitivity. C54C6.4 C54C6.4 Protein of unknown function C54C6.5 C54C6.5 Protein of unknown function C54C8.1 C54C8.1 Protein containing nuclear hormone receptor ligand-binding and C4-type zinc finger domains, has weak similarity to a region of the glucocorticoid receptor (mouse Nr3c1), which is a transcription factor that inhibits inflammation and regulates apoptosis Zinc finger, C4 type (two domains) C54C8.11 gly-15;C54C8.11 Member of the core-2 or I-branching enzyme family, which form blood group I-antigens or side-chains of O-glycans, has low similarity to core 2 beta-1,6-N-acetylglucosaminyltransferase (rat Gcnt1), which forms O-glycan branched structures beta-1,6-N-acetylglucosaminyltransferase like; gly-15 encodes a protein similar to 2/I N-acetylglucosaminyltransferase; gly-15 expressed only in cellular processes that are probably part of the secretory network of the G2 gland cells. C54C8.2 C54C8.2 Protein of unknown function, has high similarity to uncharacterized C. elegans F56H6.6 C54C8.3 C54C8.3 Member of the galactosyltransferase family, which transfer galactose to GlcNAc termini of growing oligosaccharides chains, has low similarity to UDP-Gal:betaGlcNAc beta 1 3-galactosyltransferase polypeptide 5 (beta 3 galactosyltransferase, human B3GALT5) C54C8.4 C54C8.4 Protein of unknown function, has moderate similarity to uncharacterized C. elegans F46F5.14 glycosyltransferase C54C8.5 C54C8.5 Protein with moderate similarity to beta-1,3-glucuronyltransferase 3 (glucuronosyltransferase I, human B3GAT3), which is a type II transmembrane protein that catalyzes the transfer of a glucuronic acid to a specific trisaccharide primer C54C8.6 C54C8.6 Protein with moderate similarity to C. elegans C17G10.5 gene product C54C8.7 C54C8.7 Member of the C-type lectin family, has similarity to human C-type mannose receptor MRC1, has similarity to D. melanogaster TOLLOID and TOLKIN proteins C-type lectin domain C54C8.9 C54C8.9 Protein of unknown function C54D1.1 C54D1.1 Member of the ABC transporter family, contains an ABC transporter transmembrane domain, has low similarity to P-glycoprotein (ATP-binding cassette subfamily B member 1) (mouse Abcb1b), which is a multidrug efflux pump multidrug-resistance protein; This gene encodes a protein predicted by Eisenberg and coworkers, with 52% accuracy, to be mitochondrial. C54D1.2 C54D1.2 Member of the C-type lectin family, has similarity to human secretory pancreatic stone protein PSP-S C-type lectin C54D1.3 ist-1;C54D1.3 Protein of unknown function ist-1 encodes a pleckstrin homology (PH) and phosphotyrosine binding (PTB) domain-containing insulin receptor substrate (IRS) homolog that negatively regulates lifespan and dauer development; IST-1 potentiates insulin-like signaling, although it is not absolutely required for such signaling under most conditions; in addition to acting through the AGE-1/PI3K branch of the insulin-like signaling pathway, IST-1 may also function in a parallel pathway to activate downstream protein-kinase Bs encoded by akt-1 and akt-2. C54D1.4 C54D1.4 Protein with high similarity to human ALDH8A1, which is an aldehyde dehyrdogenase that metabolizes a variety of aldehydes, including 9-cis-retinal, member of the aldehyde dehydrogenase family, which use NADP as a cofactor aldehyde dehydrogenase C54D1.5 C54D1.5 Member of the laminin protein family C54D1.6 bar-1;C54D1.6 Beta-catenin; strongly similar to human CTNNB1 protein, beta-1 catenin; binds POP-1 and activates Wnt target genes beta-catenin; a beta-catenin/armadillo homolog that affects vulva cell specification and cell migration; genetically interacts with wnt and let-60 ras signalling pathways, is expressed in P3. | a beta-catenin/armadillo homolog that affects vulva cell specification and cell migration; genetically interacts with wnt and let-60 ras signalling pathways, is expressed in P3.p through P8.p in the late L1/early L2 stage, and in the seam cells, cells in the somatic gonad and P12. C54D10.1 C54D10.1 Protein containing a glutathione S-transferase C-terminal domain, which may be involved in conjugation of reduced glutathione to various targets, has high similarity to uncharacterized C. elegans C54D10.2 glutathione S-transferase C54D10.10 C54D10.10 Protein containing two kunitz or bovine pancreatic trypsin inhibitor domains, has low similarity to uncharacterized C. elegans F35B12.6 serine protease inhibitor C54D10.2 C54D10.2 Protein containing a glutathione S-transferase C-terminal domain, which may be involved in conjugation of reduced glutathione to various targets, has high similarity to uncharacterized C. elegans C54D10.1 glutathione S-transferase C54D10.3 C54D10.3 Protein of unknown function, has moderate similarity to uncharacterized C. elegans C46H11.7 C54D10.4 C54D10.4 Protein of unknown function C54D10.5 C54D10.5 Protein of unknown function, has moderate similarity to uncharacterized C. elegans F20A1.2 C54D10.6 C54D10.6 Member of the 7-transmembrane chemoreceptor family of G protein-coupled receptors (GPCR), has low similarity to C. elegans H27D07.6 G-protein coupled receptor, srh family C54D10.7 C54D10.7 Putative coiled-coil protein C54D10.8 C54D10.8 Coiled-coil protein C54D10.9 C54D10.9 Protein of unknown function C54D2.1 C54D2.1 Protein containing an EB module domain C54D2.2 C54D2.2 Protein of unknown function C54D2.4 C54D2.4 Member of the sulfatase family, which hydrolyze sulfate esters, has low similarity to a region of arylsulfatase B (N-acetylgalactosamine 4-sulfatase, rat Arsb), which hydrolyzes sulfate ester groups from N-acetylgalactosamine 4-sulfate of dermatan sulfate sul-3 is orthologous to the human gene ARYLSULFATASE B (ARSB; OMIM:253200), which when mutated leads to mucopolysaccharidosis type VI. C54D2.5 cca-1;C54D2.5 Protein with high similarity to calcium channel voltage-dependent alpha 1H subunit (human CACNA1H), which is a pore-forming subunit of the low voltage-gated T-type calcium channel, member of the ion transport family Skeletal muscle calcium channel alpha-1 subunit; cca-1 encodes a low-voltage-activated (T-type) calcium channel; CCA-1 is required for normal pharyngeal pumping, and in conjunction with UNC-2, a high-threshold calcium channel (N- and P/Q-type), may also play a role in defecation and egg-laying; CCA-1 is expressed in the pharyngeal MC motor neuron, head neurons, the ventral nerve cord, the anterior-most body-wall muscles, and cells in the tail region. C54E10.1 C54E10.1 Protein of unknown function, has low similarity to uncharacterized C. elegans K06B9.4 C54E10.2 C54E10.2 Protein containing a putative EF-hand domain, has a region of low similarity to a region of kv4 channel-interacting protein 2 (rat Kcnip2), which may regulate Kv4 potassium channels via interaction with alpha subunits EF hand C54E10.3 C54E10.3 Putative ortholog of C. elegans C50H11.13 gene product C54E10.4 C54E10.4 Member of the 7-transmembrane chemoreceptor family of G protein-coupled receptors (GPCR), has high similarity to uncharacterized C. elegans T22H2.1 7TM chemoreceptor, sri family C54E10.5 C54E10.5 Protein containing two nuclear hormone receptor C4-type zinc finger domains, has low similarity to C. elegans NHR-58, which is involved in embryogenesis and morphogenesis Zinc finger, C4 type (two domains) C54E10.6 C54E10.6 Small protein containing a CHROMO (CHRromatin Organization MOdifier) domain and a coiled-coil region, has similarity to C. elegans CEC-1 C54E4.1 C54E4.1 Protein of unknown function C54E4.2 C54E4.2 Protein containing a thyroglobulin type-1 repeat, which may be involved in the control of proteolytic degradation C54E4.3 gcy-37;C54E4.3 Protein containing an adenylate and guanylate cyclase catalytic domain, has low similarity to rat Gucy1b2, which is the beta 2 subunit of the enzyme guanylate cyclase that converts GTP to cGMP guanylate cyclase; gcy-37 encodes a predicted soluble guanylyl cyclase that is expressed in four candidate sensory neurons connected to the pseudocoelom, URXL, URXR, AQR, and PQR; as loss of gcy-37 activity via RNA-mediated interference does not result in any abnormalities, the precise role of GCY-37 in C. elegans development and/or behavior is not yet known; GCY-37 expression in neurons connected to the pseudocoelom suggests, however, that GCY-37 may play a role in fluid homeostasis. C54E4.4 C54E4.4 Protein of unknown function C54E4.5 C54E4.5 Protein of unknown function, has a region of high similarity to a region of mouse Aldrl6, which is a cytoplasmic oxidoreductase C54F6.1 C54F6.1 Member of the 7-transmembrane chemoreceptor family of G protein-coupled receptors (GPCR), has moderate similarity to uncharacterized C. elegans F31F4.6 7TM chemoreceptor, srh family C54F6.10 C54F6.10 Member of the 7-transmembrane chemoreceptor family of G protein-coupled receptors (GPCR), has high similarity to uncharacterized C. elegans T27C4.3 7TM chemoreceptor, str family C54F6.11 C54F6.11 Protein with strong similarity to C. elegans C54F6.6 gene product 7TM chemoreceptor, srb family C54F6.12 C54F6.12 Protein of unknown function, has weak similarity to uncharacterized C. elegans F59E11.7 C54F6.13 C54F6.13 Member of the sodium or hydrogen exchanger family, which maintain the pH of actively metabolizing cells, has moderate similarity to solute carrier family 9 isoform 5 (sodium-hydrogen exchanger 5, human SLC9A5), which is a sodium-hydrogen antiporter nhx-3 encodes a sodium/proton exchanger expressed intracellularly (in elliptical, randomly distributed dots that might be multivesicular or Ward bodies) within hypodermal cells of the main body syncytium, socket cells, and the excretory pore cell, as well as (in adults) within uterine cells (probably ut1) in the region closest to the vulva, in spermathecal junction cells; nhx-3 has no obvious phenotype in mass RNAi screens; NHX-3 is thought to prevent intracellular acidification by catalysing the electroneutral exchange of vesicular sodium for an intracellular proton; speculatively, NHX-3 might enable hypodermis-specific secretion of cuticle or phagocytosis. C54F6.14 C54F6.14 Protein with high similarity to ferritin heavy chain (mouse Fth), which is an iron-storage protein that has roles in iron homeostasis and metabolism, member of the ferritin family of non-heme iron storage proteins ferritin heavy chain; ftn-1 encodes a protein with homology to human ferritin heavy chain (feriitin H subunit). C54F6.3 C54F6.3 Protein of unknown function, has high similarity to uncharacterized C. elegans F49D11.3 C54F6.4 C54F6.4 Member of the MtN3-saliva family, which contain a region of two transmembrane helices, has moderate similarity to uncharacterized C. elegans K02D7.5 C54F6.5 C54F6.5 Protein of unknown function, has weak similarity to C. elegans C54F6.6 C54F6.6 C54F6.6 Protein with strong similarity to C. elegans C54F6.11 gene product C54F6.7 C54F6.7 Protein with strong similarity to C. elegans C54F6.11 gene product 7TM chemoreceptor, srb family C54F6.8 C54F6.8 Protein containing nuclear hormone receptor C4-type zinc finger and ligand-binding domains, has moderate similarity to C. elegans NHR-51, which is involved in developmental processes nuclear hormone receptor C54F6.9 C54F6.9 Protein containing a nuclear hormone receptor ligand-binding domain, has moderate similarity to C. elegans NHR-51, which is involved in developmental processes C54G10.1 C54G10.1 Protein of unknown function C54G10.2 C54G10.2 Member of the ATPase family associated with various cellular activities, has low similarity to replication factor C (activator 1, human RFC1), which is the large subunit of the DNA replication factor C complex replication factor C 140 KD subunit like C54G10.3 C54G10.3 Member of the ABC transporter family, has low similarity to ATP-binding cassette subfamily D (ALD) member 3 (human ABCD3), which is involved in the peroxisomal import of fatty acids and fatty acyl-CoAs and plays a role in peroxisome biogenesis peroxisomal membrane protein (PMP70) C54G10.4 C54G10.4 Member of the mitochondrial carrier protein family of membrane transporters, has moderate similarity to solute carrier family 25 member 20 (human SLC25A20), which functions in fatty acid oxidation and is associated with hypoglycemia and cardiac problems mitochrondrial carrier protein C54G4.1 C54G4.1 Protein with high similarity to ribosomal protein S6 kinase A5 (human RPS6KA5), contains two protein kinase C-terminal domains and a protein kinase domain Protein kinase C terminal domain C54G4.2 C54G4.2 Protein of unknown function, has moderate similarity to uncharacterized C. elegans C09G5.7 C54G4.3 C54G4.3 Protein of unknown function, has strong similarity to uncharacterized C. elegans F58D5.7 C54G4.4 C54G4.4 Protein with similarity to selectins of D. melanogaster (FW, furrowed) and human (SELE), member of the C-type lectin family sushi repeats C54G4.5 C54G4.5 Protein of unknown function C54G4.6 C54G4.6 Member of the Maf-like protein family, which may be inhibitors of septum formation, has low similarity to uncharacterized S. pombe Spac3G6.03cp MAF protein; This gene encodes a protein predicted by Eisenberg and coworkers, with 68% accuracy, to be mitochondrial. C54G4.7 C54G4.7 Protein of unknown function C54G4.8 C54G4.8 Putative cytochrome c1, predicted member of the cytochrome bc1 complex cytochrome C1, heme protein C54G4.9 C54G4.9 Protein of unknown function C54G6.1 C54G6.1 Protein of unknown function C54G6.2 C54G6.2 Protein of unknown function, has weak similarity in the C-terminus to human XRP2 (Hs.44766) The C54G6.2 gene encodes a homolog of human RP2, which when mutated leads to X-linked retinitis pigmentosa 2 (OMIM:312600). C54G6.3 C54G6.3 Protein with moderate similarity to C. elegans F49E12.7 gene product C54G6.5 C54G6.5 Protein with strong similarity to C. elegans Y34D9A.G gene product C54G7.1 C54G7.1 Protein with moderate similarity to C. elegans C09G5.8 gene product C54G7.2 C54G7.2 Member of the membrane bound O-acyl transferase (MBOAT) family, which are found in acyltransferase enzymes, has moderate similarity to uncharacterized C. elegans C08F8.4 C54G7.3 lgx-1;C54G7.3 Protein containing 13 EB module domains, has weak similarity to uncharacterized C. elegans F46C8.4 lgx-1 encodes a protein with eight EB modules (worm-specific domains, containing eight conserved cysteines that probably form four disulphide bridges, that are of unknown function) and a glutamine/asparagine (Q/N)-rich domain. C54G7.4 C54G7.4 Protein containing three WD domains (WD-40 repeat), which may mediate protein-protein interactions C54H2.1 C54H2.1 Protein of unknown function sym-3 encodes a novel protein that has no recognizably conserved domains, but does have homologs in Drosophila, mouse, and human; mutations in sym-3, while producing no phenotype on their own, are synthetically lethal with loss-of-function mutations in mec-8, which encodes a regulator of alternative RNA splicing; although the precise function of sym-3 is not yet known, sym-3 activity appears to be required for some aspects of pharyngeal differentiation, as mec-8; sym-3 double mutants arrest as late-stage embryos or L1 larvae with pharynges that, despite normal morphology, do not attach to the outer cuticle to allow for feeding. C54H2.2 C54H2.2 Member of the transposase family, which are required for excising and inserting mobile genetic elements, has very strong similarity to uncharacterized C. elegans C06B8.5 transposase C54H2.3 C54H2.3 Member of the zinc finger in Ran binding proteins family, which may be involved in nuclear transport C54H2.4 C54H2.4 Protein of unknown function C54H2.5 sft-4;SURF-4;C54H2.5 Protein with high similarity to surfeit gene 4 (mouse Surf4), which is an integral membrane protein predicted to have housekeeping roles, member of the SURF4 (surfeit locus) family sft-4 encodes a member of the SURF family highly conserved with the mouse Surf-4 gene, and conservation includes an encoded dilysine motif that is implicated in endoplasmic reticulum localization of the mouse protein. C55A1.1 C55A1.1 Member of the 7-transmembrane chemoreceptor family of G protein-coupled receptors (GPCR), has high similarity to uncharacterized C. elegans Y102A5C.28 C55A1.10 C55A1.10 Member of the 7-transmembrane chemoreceptor family of G protein-coupled receptors (GPCR), has moderate similarity to uncharacterized C. elegans F57G8.1 C55A1.11 F53E4.1;C55A1.11 Protein containing six Kelch motif domains, has low similarity to a region of S. pombe Tea1p, which is required for the initiation of bipolar growth and for the correct localization of growing tips C55A1.2 C55A1.2 Protein with strong similarity to C. elegans K04C1.6 gene product C55A1.3 C55A1.3 Member of the 7-transmembrane chemoreceptor family of G protein-coupled receptors (GPCR), has low similarity to C. elegans ODR-10, which is a G protein-coupled receptor involved in odorant response C55A1.4 C55A1.4 Protein of unknown function, has very strong similarity to uncharacterized C. elegans C55A1.7 C55A1.5 C55A1.5 Member of the 7-transmembrane chemoreceptor family of G protein-coupled receptors (GPCR), has low similarity to C. elegans ODR-10, which is involved in odorant response C55A1.6 C55A1.6 Protein of unknown function, has high similarity to uncharacterized C. elegans F14D7.7 C55A1.7 C55A1.7 Protein of unknown function, has very strong similarity to uncharacterized C. elegans C55A1.4 C55A1.8 C55A1.8 Protein containing a DUF215 domain of unknown function, has moderate similarity to uncharacterized C. elegans R07B5.4 C55A1.9 C55A1.9 Protein of unknown function, has high similarity to uncharacterized C. elegans ZK380.4 C55A6.1 C55A6.1 Protein with weak similarity to C. elegans C26B9.6 Zinc finger, C3HC4 type (RING finger) C55A6.10 C55A6.10 Protein of unknown function C55A6.2 C55A6.2 Member of the tubulin-tyrosine ligase family Human KIAA0173 protein like C55A6.3 C55A6.3 Member of the alcohol dehydrogenase protein family dehydrogenase C55A6.4 C55A6.4 Member of the alcohol dehydrogenase protein family alcohol dehydrogenase C55A6.5 C55A6.5 Member of the alcohol/ribitol dehydrogenase-like protein family alcohol dehydrogenase C55A6.6 C55A6.6 Member of the alcohol/ribitol dehydrogenase-like protein family alcohol dehydrogenase C55A6.7 C55A6.7 Member of the alcohol/ribitol dehydrogenase-like protein family alcohol dehydrogenase C55A6.8 C55A6.8 Protein of unknown function, has high similarity to uncharacterized C. elegans C55A6.6 dehydrogenase C55A6.9 C55A6.9 Protein with weak similarity to S. cerevisiae Paf1p (protein associated with RNA polymerase II), has similarity to human HS.152894 C55B6.1 C55B6.1 Protein containing an FGGY family of carbohydrate kinases C-terminal domain and an N-terminal domain, has weak similarity to glycerol kinase (mouse Gk), which catalyzes the phosphorylation of glycerol to glycerol 3-phosphate glycerol kinase C55B6.2 C55B6.2 Protein with high similarity to protein kinase inhibitor p58 (human DNAJC3), which may act as a cochaperone that inhibits double-stranded RNA-dependent protein kinase (human PRKR), contains a DnaJ and six TPR (tetratrico peptide repeat) domains This gene encodes a protein containing a DnaJ ('J') domain that is predicted to be mitochondrial. C55B6.3 C55B6.3 Protein of unknown function C55B6.4 C55B6.4 Protein of unknown function C55B6.5 C55B6.5 Protein containing a protein kinase domain C55B7.1 glh-2;C55B7.1 Putative RNA helicase in the germ line and localized to P granules; putative ortholog of S. cerevisiae DBP1 gene product [ATP-dependent RNA helicase of the DEAD box family] RNA helicase; glh-2 encodes a putative DEAD-box RNA helicase that contains six CCHC zinc fingers and is homologous to Drosophila VASA, a germ-line-specific, ATP-dependent, RNA helicase; at non-permissive temperatures, GLH-2 plays a role in germ-line development and fertility, specifically in regulating the normal extent of germ-line proliferation, oogenesis, and the production of functional sperm; GLH-2 activity may also be required for the wild-type morphology of P granules and for localization of several protein components, but not accumulation of P granule mRNA components; GLH-2 interacts in vitro with itself and with KGB-1, a JNK-like MAP kinase; GLH-2 is a constitutive P granule component and thus, with the exception of mature sperm, is expressed in germ cells at all stages of development; GLH-2 is cytoplasmic in oocytes and the early embryo, while perinuclear in all later developmental stages as well as in the distal and medial regions of the hermaphrodite gonad; GLH-2 is expressed at barely detectable levels in males. C55B7.10 C55B7.10 Protein containing two protein kinase domains, has low similarity to casein kinase 1 alpha 1 (rat Csnk1a1), which is a serine-threonine protein kinase that may play a role in signal transduction casein kinase C55B7.11 C55B7.11 Protein with moderate similarity to C. elegans F27C8.5 gene product C55B7.12 C55B7.12 Protein containing four C2H2 type zinc finger domains, has a region of high similarity to a region of zinc-finger protein 91 (human ZNF91), which functions as a transcriptional repressor and may play a role in formation of seminomas zinc finger prtoein; che-1 encodes a C2H2-type zinc finger-containing transcription factor orthologous to Drosophila GLASS, which is required for photoreceptor cell differentiation; CHE-1 is required for determining the identity and function of the amphid ASE neurons, the major neurons that mediate chemotaxis to water-soluble attractants; CHE-1 is expressed predominantly in the ASE neurons and regulates, either directly or indirectly, the expression of a number of ASE-specific genes. C55B7.2 gly-2;C55B7.2 Protein with moderate similarity to n-acetylglucosaminyltransferase V (human MGAT5), which catalyzes beta-1 6 branching on N-linked carbohydrates and may play a role in tumor invasiveness alpha-1,3(6)-mannosylglycoprotein beta-1,6-N-acetyl-glucosaminyltransferase; gly-2 encodes a functional homolog of mammalian UDP-N-acetylglucosamine alpha-6-d-mannoside beta-1,6-N-acetylglucosaminyltransferase V (GlcNAc-TV) which regulates polylactosamine-containing N-glycans; gly-2 is functionally interchangeable with the mammalian gene; GLY-2 is expressed in late embryos and in a subset of neurons in larvae, spermathecal and pharyngeal-intestinal valves and in specific vulval cells of adults. C55B7.3 F10G8.1;C55B7.3 Putative tyrosine protein phosphatase protein-tyrosine phosphatase C55B7.4 C55B7.4 Member of the acyl-CoA dehydrogenase protein family acyl-CoA dehydrogenase C55B7.5 C55B7.5 Protein of unknown function C55B7.6 C55B7.6 Protein with moderate similarity to sulfate transporters C55B7.7 C55B7.7 Protein with similarity to human Hs.3830 gene product, protein KIAA0893 isolated from a brain cDNA library C55B7.8 dbr-1;Ce-dbr1;C55B7.8 Functional ortholog of S. cerevisiae Dbr1p, lariat RNA debranching enzyme lariat debranching enzyme; dbr-1 encodes a homolog of the RNA lariat-debranching enzyme; DBR-1 is predicted to function in RNA processing by hydrolyzing the 2'-5' phosphodiester bond at the branchpoint of excised lariat intron RNA, thus converting the introns into linear molecules that can subsequently be degraded by exonucleases; in C. elegans, DBR-1 activity is required for embryonic and germline development, as well as for normal rates of postembryonic growth; overexpression of C. elegans DBR-1 in Saccharomyces cerevisiae can complement the RNA processing defects of a dbr1 null mutant strain, restoring debranching activity and intron degradation to near wild-type levels. C55B7.9 C55B7.9 Protein of unknown function, has low similarity to uncharacterized human FLJ20045 C55C2.1 C55C2.1 Protein containing three C2H2 type zinc finger domains, has a region of high similarity to a region of zinc finger protein 293 (mouse Zfp293), which is a Snail-related transcriptional repressor that regulates basic helix-loop-helix transcription factors zinc-finger transcription factor C55C2.2 C55C2.2 Protein containing a major sperm protein (MSP) domain, which are involved in sperm motility, has strong similarity to uncharacterized C. elegans K07F5.9 C55C2.3 C55C2.3 Protein of unknown function, has low similarity to uncharacterized C. elegans C55C2.4 C55C2.4 C55C2.4 Protein of unknown function, has low similarity to uncharacterized C. elegans C55C2.3 C55C2.5 C55C2.5 Member of the amino acid permease family of membrane transporters, has low similarity to solute carrier family 7 member 11 (human SLC7A11), which is a high affinity cystine and glutamate transporter amino acid permease C55C3.1 C55C3.1 Protein containing lipopolysaccharide-binding protein, bactericidal permeability-increasing protein, or cholesteryl ester transfer protein N-terminal and C-terminal domains, has weak similarity to uncharacterized C. elegans F01G10.1 C55C3.2 C55C3.2 Protein of unknown function, has weak similarity to C. elegans C27A2.1 C55C3.3 C55C3.3 Protein of unknown function, has strong similarity over N-terminal 252 amino acids to C. elegans F23B2.7 C55C3.4 C55C3.4 Protein containing a protein kinase domain and a Src homology 2 (SH2) domain, has moderate similarity to fer (fps/fes related) tyrosine kinase (mouse Fert2), which may mediate cell-cell signaling and cell size-dependent cytoskeletal reorganization tyrosine-protein kinase C55C3.5 C55C3.5 Protein of unknown function C55C3.6 C55C3.6 Putative ortholog of C. elegans F23B2.7 gene product C55F2.1 C55F2.1 Protein with high similarity to 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase and IMP cyclohydrolase (human ATIC), member of the AICARFT or IMPCHase bifunctional enzyme family, contains two methylglyoxal synthase (MGS)-like domains transferase C55F2.2 C55F2.2 Protein of unknown function, has a region of moderate similarity to a region of C. elegans F22A3.6, which is a putative lysozyme involved in embryogenesis and morphogenesis C55H1.1 C55H1.1 Putative ortholog of C. elegans C10H11.3 gene product C55H1.2 gpa-10;C55H1.2 Member of the G protein alpha subunit family guanine nucleotide-binding protein; gpa-10 encodes a member of the G protein alpha subunit family of heterotrimeric GTPases; it is expressed in ADF, ASI, ASJ, ALN, CAN, LUA, and the spermatheca. C56A3.1 C56A3.1 Protein of unknown function containing a Ground-like domain, has weak similarity to C. elegans Y47D7A_146.B C56A3.2 C56A3.2 Member of the transthyretin-like family, has high similarity to uncharacterized C. elegans T07C12.7 Transthyretin-like family C56A3.3 C56A3.3 Protein of unknown function, has low similarity to uncharacterized C. elegans T14C1.1 7tm receptor; C56A3.3 encodes a homolog of the functionally active Fmrf Receptor (FR; CG2114) of D. melanogaster; it is thus possible that C56A3.3 is a receptor for one of the FMRF-like neurotransmitters in C. elegans (e.g., FLP-1 through FLP-12). C56A3.4 C56A3.4 Protein with weak similarity to H. sapiens Hs.32316 (Homo sapiens mRNA for KIAA0544 protein, partial cds) Zinc finger, C3HC4 type (RING finger) C56A3.5 C56A3.5 Protein of unknown function C56A3.6 C56A3.6 Protein containing four EF hand domains, has low similarity to a region of calcium binding atopy-related autoantigen 1 (human CBARA1), which is an intracellular protein that acts as an IgE-binding antigen and is involved in the immune response EF hand (2 domains) C56A3.7 cav-2;C56A3.7 Member of the caveolin family, which are major membrane components of cavoleae, has a region of low similarity to caveolin 1 (mouse Cav), which is a tumor suppressor and structural component of caveolar membranes that is involved in signal transduction Caveolin; cav-2 encodes one of two C. elegans proteins related to caveolins, integral transmembrane proteins that are believed to function in regulation of signal transduction and that are the major component of caveolae, specialized lipid rafts found in the plasma membrane of most cell types; as loss of cav-2 function via large-scale RNA-mediated interference (RNAi) screens does not result in any obvious abnormalities, the role of cav-2 in C. elegans development and/or behavior is not yet known; cav-2 mRNA is expressed in eggs and mixed stage populations. C56A3.8 C56A3.8 Protein with moderate similarity to phosphatidylinositol 4-kinase type II (rat Pi4kii), which is a membrane-bound phosphatidylinositol kinase that may be involved in glucose transport and T cell activation C56C10.1 C56C10.1 Member of the Sec 1 family, which may be involved in secretion, has weak similarity to vacuolar sorting protein 33a (rat Vps33a), which may be involved in vesicular transport from endosomes to lysosomes C56C10.10 C56C10.10 Protein containing two TPR (tetratrico peptide repeat) domains, which may mediate protein-protein interactions, has low similarity to aryl hydrocarbon receptor interacting protein (human AIP), which binds unliganded Ah receptor (human AHR) and HSP90 TPR domain C56C10.11 C56C10.11 Large protein of unknown function, contains a DnaJ domain DNAJ protein C56C10.12 C56C10.12 Protein of unknown function, has weak similarity to uncharacterized human KIAA1632 C56C10.13 C56C10.13 Protein with moderate similarity to C. elegans Y47H9C.5 gene product This gene encodes a protein containing a DnaJ ('J') domain. C56C10.3 C56C10.3 Protein of unknown function, has high similarity to C. elegans C37C3.3 C56C10.4 C56C10.4 Protein containing a DB module domain, has high similarity to uncharacterized C. elegans C42D4.3 C56C10.5 C56C10.5 Protein of unknown function, has high similarity to uncharacterized C. elegans F18C5.8 7TM chemoreceptor, sra family C56C10.6 C56C10.6 Protein containing a protein kinase domain, has low similarity to casein kinase 1 gamma 3 (rat Csnk1g3), which is a serine-threonine protein kinase that may play roles in cell growth and in morphogenesis Casein kinase C56C10.7 C56C10.7 Protein of unknown function C56C10.8 C56C10.8 Protein with high similarity to basic transcription factor 3 (human BTF3), which complexes with RNA polymerase II and that is required for transcriptional initiation, contains a nascent polypeptide-associated complex (NAC) alpha protein domain Transcription factor BTF3 (human) C56C10.9 C56C10.9 Protein containing six EF hand domains, has low similarity to reticulocalbin 2 (human RCN2), which is an endoplasmic reticulum calcium-binding protein that interacts with the papillomavirus E6 oncoprotein C56E10.1 C56E10.1 Protein containing a nuclear hormone receptor C4-type zinc finger domain, which bind DNA and may be involved in regulation of transcription, and a nuclear hormone receptor ligand-binding domain, has low similarity to uncharacterized C. elegans NHR-60 steroid zinc finger C56E10.2 C56E10.2 Protein of unknown function C56E10.3 C56E10.3 Coiled-coil protein, has weak similarity to myosin heavy chains C56E10.4 C56E10.4 Protein containing a nuclear hormone receptor ligand-binding domain and a nuclear hormone receptor C4-type zinc finger domain, which bind DNA and may be involved in regulation of transcription C56E6.1 C56E6.1 Protein of unknown function, has a region of low similarity to a region of sterolin 1 (human ABCG5), which may be an ATP-binding cassette (ABC) transporter and is associated with sitosterolemia, hypercholesterolemia, and premature coronary atherosclerosis C56E6.2 C56E6.2 Member of the Ras superfamily of GTP-binding proteins, has a region of moderate similarity to S. cerevisiae Ypt6p, which is a GTP-binding protein involved in the secretory pathway GTP-binding C56E6.3 C56E6.3 Protein with moderate similarity to C. elegans C02E7.10 gene product C56E6.4 C56E6.4 Protein of unknown function C56E6.5 C56E6.5 Member of the ABC transporter family, has weak similarity to ATP-binding cassette subfamily G member 2 (breast cancer resistance protein) (human ABCG2), which is a phospholipid and cholesterol transporter involved in developing multidrug resistance ATP-binding C56E6.6 C56E6.6 Protein containing leucine rich repeats, which mediate protein-protein interactions, has a region of low similarity to a region of toll-like receptor 3 (mouse Tlr3), which is involved in inflammatory response, response to viruses, and cell proliferation leucine-rich repeats C56G2.1 C56G2.1 Protein containing a KH domain and a tudor domain, has a region of low similarity to a region of a kinase anchor protein (mouse Akap), which anchors protein kinase A to subcellular locations C56G2.15 C56G2.15 Protein containing an acetyltransferase (GNAT) domain, has low similarity to a region of human FUS2, which has N-acetyltransferase activity and is a putative tumor suppressor C56G2.3 C56G2.3 Protein of unknown function, has low similarity to uncharacterized C. elegans F46F11.10 C56G2.4 C56G2.4 Member of the phosphatidylethanolamine-binding protein family, which may be involved in membrane remodeling during growth and maturation C56G2.5 C56G2.5 Protein containing a putative protein kinase domain, has similarity across the middle region to human protein kinase C-like proteins PRKCL1 and PRKCL2 and to C. elegans serine/threonine protein kinase F46F6.2 Protein kinase C56G2.6 C56G2.6 Possible estradiol 17 beta-dehydrogenase, member of a protein family let-767 encodes a short-chain dehydrogenase, reported to be required for efficient cholesterol metabolism; LET-767 is predicted to be required for the metabolism of a sterol and to be mitochondrial. C56G2.7 C56G2.7 Protein of unknown function, has a region of low similarity to integral plasma membrane glycoprotein (rat Gp110), which is a type I transmembrane glycoprotein that mediates Ca2+ -independent cell-cell adhesion C56G2.8 C56G2.8 Protein of unknown function C56G3.1 C56G3.1 Member of the rhodopsin family of G protein-coupled receptors (GPCR), has weak similarity to neuropeptide Y-Y2 receptor (human NPY2R), which signals through intracellular cAMP levels and calcium flux G-protein coupled receptors (family 1) C56G3.2 C56G3.2 Member of the aldo-keto reductase family, which include some related monomeric NADPH-dependent oxidoreductases, has high similarity to uncharacterized C. elegans C07D8.6 aldo/keto reductase family C56G7.1 mlc-4;C56G7.1 Putative non-muscle myosin light chain myosin regulatory light chain 2 C56G7.2 C56G7.2 Protein of unknown function, has weak similarity to C. elegans T22G5.3 This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins. C56G7.3 C56G7.3 Protein of unknown function CAT2 ctl-1;cat2 Cytosolic catalase CC4.2 nlp-15;CC4.2 Protein with moderate similarity to C. elegans D1009.4 gene product CC4.3 smu-1;CC4.3 Protein that may be involved in splice site selection in alternative mRNA splicing WD domain, G-beta repeats (2 domains) CC8.1 CC8.1 Protein of unknown function CC8.2 CC8.2 Putative paralog of C. elegans F15G10.1 CD4.1 CD4.1 Protein of unknown function CD4.2 CD4.2 Member of the TatD-related DNase family, has low similarity to uncharacterized human CDA11 crn-2 encodes a cell death-related nuclease, homologous to the magnesium-dependant TatD nuclease of E. coli; CRN-2 is required for normal levels of DNA degradation during apoptosis; crn-2(RNAi) 1.5-fold stage embryos display TUNEL labelling of nuclei that is five-fold higher than that seen in untreated N2 animals; CRN-2 promotes both DNA degradation and cell corpse engulfment, in a partially redundant pathway that includes CRN-3 but is parallel to CPS-6; CRN-2 is predicted to be mitochondrial. CD4.3 CD4.3 Possible large ribosomal subunit protein CD4.4 CD4.4 Protein of unknown function, has weak similarity to D. melanogaster EG:115C2.5 CD4.5 CD4.5 Protein with strong similarity to C. elegans T19B10.9 gene product CD4.6 pas-6;CD4.6 Putative alpha-type subunit of 20S proteasome particle protease; pas-6 encodes a type 1 alpha subunit of the 26S proteasome's 20S protease core particle (CP); PAS-6 is required for embryonic, larval, and germline development and by homology, is predicted to comprise the outer rings of the proteasome and to play a role in selective degradation of ubiquitinated proteins during development; in vitro, PAS-6 interacts with BRP-1, a glutamine/asparagine (Q/N)-rich domain-containing protein conserved amongst nematodes, and with other members of the proteasome. CD4.7 CD4.7 Protein of unknown function CD4.8 CD4.8 Protein of unknown function, has high similarity to uncharacterized C. elegans T28A8.6 CD4.9 CD4.9 Protein containing a low-density lipoprotein (LDL) receptor class A domain CDK-7 cdk-7 Protein with high similarity to cyclin-dependent protein kinase 7 (human CDK7), which is a component of CDK-activating kinase (CAK) that is a subunit of polymerase II transcription initiator TFIIIH, contains a protein kinase domain CE-FKH-1 pha-4;fkh-1;Ce-fkh-1 Specifies the pharyngeal cell fate CE-SEMA-2A mab-20;Ce-Sema-2a Putative member of Ig superfamily that is required for cell guidance and migration CED6.1 C17G10.8;fat-3;Ced6.1 Member of the alcohol/ribitol dehydrogenase-like protein family CEHD-28 Cehd-28 Putative tyrosine protein kinase CEHD-39 Cehd-39 Putative tyrosine protein kinase CEKRP85 krp85;CeKRP85 Motor subunit of the heterotrimeric CeKinesin-II motor complex CHP-1 chp-1 CHORD domain containing protein that appears to be required for early embryonic development as well as later development of the hermaphrodite vulva and germ cells CLH-3 clh-3 Chloride channel protein, clc-5 paralogue COI COX1;coi Protein with high similarity to mitochondrial cytochrome c oxidase subunit I (human MTCO1), which is a respiratory chain complex IV subunit associated with mitochondrial disease and anemia, member of the cytochrome C oxidase polypeptide I family COII COX2;coii Protein containing cytochrome C oxidase subunit II periplasmic and transmembrane domains, has moderate similarity to mitochondrial cytochrome c oxidase II (human MTCO2), which is associated with myopathy, lactic acidosis, epilepsy, and Alzheimer's disease COIII COX3;coiii Member of the cytochrome C oxidase subunit III family, has moderate similarity to human MTCO3, which regulates assembly and maintenance of the oxidase complex and is associated with Leigh-like syndrome and Leber's hereditary optic neuropathy COL-40 col-40 Collagen of the COL-6 family of collagens CSP-3 csp-3 Protein containing an interleukin-1 beta converting enzyme (ICE)-like protease (caspase) p10 domain, has low similarity to a region of C. elegans CED-3, which is an aspartate-specific cysteine protease that is involved in the induction of apoptosis CTEL54X.1 CTEL54X.A;CTEL54X.1 Protein containing a DUF38 domain of unknown function and an F-box domain, which serve as a link between a target protein and a ubiquitin-conjugating enzyme, has weak similarity to C. elegans FOG-2, which is required for the sexual identity of germ cells This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins; this gene's encoded protein also contains an FTH/DUF38 motif, which may also mediate protein-protein interaction. CTEL7X.A CTEL7X.1;CTEL7X.A Protein with moderate similarity to C. elegans F52C9.8 gene product CUC-1 cuc-1 Copper chaperone co-expressed with CUA-1 copper-transporting ATPase CYK-3 cyk-3 Mutations in this protein prevent completion of mitosis CYTB CYB;Cytb Protein containing a cytochrome b N-terminal domain and a cytochrome b C-terminal domain, has moderate similarity to mitochondrial cytochrome b (rat mt-Cytb), which is a subunit of mitochondrial complex III involved in cation transport D1005.1 D1005.1 Protein with high similarity to ATP citrate lyase (human ACLY), which is involved in cholesterol and fatty acid synthesis, member of the ATP-citrate lyase or succinyl-CoA ligase family, contains one CoA binding domain, which have a Rossmann fold ATP citrate lyase; This gene encodes a protein predicted by Eisenberg and coworkers, with 52% accuracy, to be mitochondrial. D1005.2 D1005.2 Member of the UTP-glucose-1-phosphate uridylyltransferase family, which catalyze formation of UDP-glucose, has moderate similarity to UDP-glucose pyrophosphorylase 2 (human UGP2), which forms UDP-glucose from glucose-1-phosphate and MgUTP D1005.3 D1005.3 Protein of unknown function, has high similarity to uncharacterized C. elegans Y44E3B.1 D1005.4 D1005.4 Protein of unknown function D1005.5 D1005.5 Protein of unknown function, has low similarity to uncharacterized C. elegans F15H10.6 D1005.6 D1005.6 Protein of unknown function D1007.1 ceh-17;ceh-42;CePhox2;D1007.1 Homeodomain transcription factor that promotes longitudinal growth of axons in certain neurons (609717) :715448 homeobox protein; ceh-17 encodes a phox-2-like homeodomain protein that is a member of the Q50 paired-like class of homeobox proteins and the vertebrate orthologue of Phox2a and Phox2b; that affects ALA and SIA axonal development; ceh-17 affects ALA and SIA antero-posterior axonal growth and navigation, and is expressed in five neurons of the ring ganglia (ALA and the 4 SIAs) with strongest expression in embryos and in L1 stage larvae. D1007.10 D1007.10 Protein of unknown function D1007.11 D1007.11 Protein of unknown function D1007.12 rpl-24;D1007.12 Member of the ribosomal L24e family, which are part of the large ribosomal subunit, has moderate similarity to ribosomal protein L24A (S. cerevisiae Rpl24ap), which is a structural ribosomal protein 60S ribosomal protein L24; rpl-24.1 encodes a large ribosomal subunit L24 protein. D1007.13 D1007.13 Protein of unknown function D1007.14 D1007.14 Protein of unknown function The protein product of this gene is predicted to contain a glutamine/asparagine (Q/N)-rich ('prion') domain, by the algorithm of Michelitsch and Weissman (as of the WS77 release of WormBase, i.e., in wormpep77). D1007.15 D1007.15 Protein of unknown function, has low similarity to uncharacterized human KIAA0195 D1007.16 D1007.16 Protein of unknown function, has weak similarity to C. elegans W09G12.7 D1007.2 D1007.2 Protein containing two collagen triple helix repeats, which are found in some extracellular proteins, has a region of moderate similarity to a region of C. elegans BLI-1 D1007.3 D1007.3 Protein of unknown function D1007.4 D1007.4 Protein of unknown function D1007.5 D1007.5 Protein of unknown function, has low similarity to uncharacterized human FLJ10902 D1007.6 rps-10;D1007.6 Protein with high similarity to ribosomal protein S10 (human RPS10), which is a component of the small 40S ribosomal subunit that is likely to play a role in translation initiation and may be associated with colorectal carcinogenesis 40S ribosomal protein S10; rps-10 encodes a small ribosomal subunit S10 protein. D1007.7 D1007.7 Protein containing an RNA recognition motif (RRM, RBD, or RNP), has low similarity to a region of human KIAA1116, which is a CTD-binding SR-like protein that functions in RNA processing RNA-binding protein D1007.8 D1007.8 Protein of unknown function D1007.9 D1007.9 Protein of unknown function D1009.1 D1009.1 Protein with high similarity to C. elegans ceFATPa, which is a fatty acid transport protein, member of the AMP-binding enzyme family fatty acid transporter protein D1009.2 cyp-8;D1009.2 Cyclophilin-related peptidylprolyl cis-trans-isomerase cyp-8 encodes a peptidyl-propyl cis-trans isomerase of the cyclophilin family; cyclophilins are implicated in protein folding, however the precise role of cyp-8 is not known; a CYP-8-fusion protein localises specifically to gut cell nuclei. D1009.3 D1009.3 Protein containing a beta or gamma fibrinogen C-terminal globular domain, has a region of low similarity to a region of angiopoietin 4 (mouse Agpt4), which is specific to the vascular endothelium and functions as a mouse Tek antagonist D1009.4 D1009.4 Protein with moderate similarity to C. elegans nlp-15 gene product D1009.5 D1009.5 Small protein with strong similarity over the C-terminus to human and D. melanogaster t-complex-associated-testis-expressed (TCTE1L and TCTEX) proteins D1014.1 D1014.1 Member of the sulfatase family, which hydrolyze sulfate esters, has low similarity to arylsulfatase F (human ARSF) arylsulfatase; sul-2 is orthologous to the human gene ARYLSULFATASE A (ARSA; OMIM:250100), which when mutated leads to metachromatic leukodystrophy. D1014.2 srq-5;D1014.2 Member of the rhodopsin family of G protein-coupled receptors (GPCR) D1014.3 D1014.3 Protein with high similarity to N-ethylmaleimide-sensitive factor (NSF) attachment protein alpha (human NAPA), which is involved in (Ca2+)-regulated membrane fusion and intra-Golgi transport, contains four aromatic-di-alanine (AdAR) repeat domains alpha-SNAP protein D1014.4 D1014.4 Protein of unknown function D1014.5 D1014.5 Protein containing a DUF138 domain of unknown function D1014.6 D1014.6 Protein containing a DUF138 domain of unknown function, has high similarity to uncharacterized C. elegans D1014.7 D1014.7 D1014.7 Protein containing a DUF138 domain of unknown function, has high similarity to uncharacterized C. elegans D1014.6 D1014.8 D1014.8 Protein containing two Myb-like DNA-binding domains and one Egl-27 and MTA1 homology 2 (ELM2) domain, which may be involved in DNA or protein-protein binding, has weak similarity to corepressor of REST (human RCOR) D1022.1 D1022.1 Member of the ubiquitin-conjugating enzyme (E2) family, has a region of moderate similarity to a region of ubiquitin-conjugating enzyme (S. cerevisiae Ubc6p), which is anchored in the ER membrane with the catalytically active domain in the cytoplasm Ubiquitin-conjugating enzyme D1022.2 D1022.2 Protein of unknown function D1022.3 D1022.3 Member of the dienelactone hydrolase family, has high similarity to uncharacterized C. elegans D1022.4 D1022.4 D1022.4 Member of the dienelactone hydrolase family, has high similarity to uncharacterized C. elegans D1022.5 D1022.5 D1022.5 Member of the dienelactone hydrolase family, has high similarity to uncharacterized C. elegans D1022.4 D1022.6 sro-1;D1022.6 Putative seven membrane receptor of the G protein-coupled receptor superfamily; possibly involved in chemosensation by sensory neurons G-protein coupled receptor D1022.7 AKAP;kap-1;D1022.7 Protein containing a FYVE zinc finger domain, which bind phosphatidylinositol 3-phosphate, has a region of weak similarity to a region of smad anchor for receptor activation (human MADHIP), which is involved in receptor-mediated activation of Smad aka-1 encodes an A kinase anchor protein that has mutiple isoforms, all of which have a zinc-finger domain of the FYVE type; interacts with KIN-2 in vitro. D1022.8 D1022.8 Protein containing two eukaryotic-type carbonic anhydrase domains, which catalyze reversible hydration of carbon dioxide, has low similarity to mitochondrial carbonic anhydrase VB (human CA5B), which may have a role in gluconeogenesis and ureagenesis Carbonic anhydrase; cah-2 encodes a predicted carbonic anhydrase. D1025.1 D1025.1 Protein of unknown function D1025.2 D1025.2 Protein with high similarity to glycine cleavage system protein H (human GCSH), which is the H-protein component of the glycine cleavage system that is associated with atypical nonketotic hyperglycinemia, member of the glycine cleavage H-protein family This gene encodes a protein predicted by Eisenberg and coworkers, with 52% accuracy, to be mitochondrial. D1025.3 D1025.3 Protein containing an F-box domain, which serve as a link between a target protein and a ubiquitin-conjugating enzyme, and a DUF38 domain of unknown function This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins; this gene's encoded protein also contains an FTH/DUF38 motif, which may also mediate protein-protein interaction. D1025.4 D1025.4 Protein of unknown function, has very strong similarity to uncharacterized C. elegans D1025.6 D1025.6 D1025.6 Putative ortholog of C. elegans D1025.4 gene product D1037.1 D1037.1 Protein with similarity to human SON DNA binding protein D1037.2 D1037.2;Ce-Sema-1b Protein with similarity to human putative DNA binding protein SON3, has similarity to two C. elegans putative semaphorins D1037.3 D1037.3 Putative ferritin, has strong similarity to human and D. melanogaster light-chain ferritins, probable paralog of C. elegans C54F6.14 ferritin; ftn-2 is orthologous to the human gene FERRITIN, HEAVY POLYPEPTIDE 1 (FTH1; OMIM:134770), which when mutated leads to disease. D1037.4 rab-8;D1037.4 GTP-binding protein of the rab family (ras superfamily); putative ortholog of human and D. melanogaster RAB8; has strong similarity to S. cerevisiae Ypt proteins of the rab family, involved in trans-golgi vesicular transport RAS-related protein; rab-8 encodes a rab related protein of the Ras GTPase superfamily that affects ovarian morphology and function, thereby affecting fertility; acts downstream of let-60 with respect to vulval development based on genetic analysis. D1037.5 D1037.5 Putative ortholog of C. elegans H23L24.2 gene product phospholipase D1043.1 D1043.1 Protein of unknown function D1044.1 D1044.1 Protein containing a DUF227 domain of unknown function, has low similarity to uncharacterized C. elegans H06H21.8 D1044.2 D1044.2 Protein of unknown function, has a region of low similarity to a region of alpha-tectorin (human TECTA), which is a major non-collagenous component of the tectorial membrane that may be involved in tectorial membrane matrix assembly D1044.3 D1044.3 Protein containing 16 EB module domains and a protein kinase domain, has a region of low similarity to NIMA (never in mitosis gene a)-related expressed kinase 6 (human NEK6), which activates the S6 ribosomal protein kinase p70S6K (RPS6KB1) The protein product of this gene is predicted to contain a glutamine/asparagine (Q/N)-rich ('prion') domain, by the algorithm of Michelitsch and Weissman (as of the WS77 release of WormBase, i.e., in wormpep77). D1044.4 D1044.4 Protein of unknown function D1044.5 D1044.5 Protein of unknown function D1044.6 D1044.6 Protein of unknown function, has moderate similarity to C. elegans C09G1.2 D1044.7 D1044.7 Putative ortholog of C. elegans D1044.3 gene product D1046.1 D1046.1 Protein with low similarity to cleavage and polyadenylation specific factor 6 (human CPSF6), which is a putative mRNA-binding protein that is the 68 kDa subunit of the mRNA cleavage factor Im (CF Im) complex and plays a role in pre-mRNA 3' end processing glycine-rich RNA-binding protein D1046.2 D1046.2 Protein containing a zinc finger domain of the C2H2 type Zinc finger, C2H2 type D1046.3 D1046.3 Member of the mitochondrial carrier protein family of membrane transporters, has low similarity to mitochondrial RNA splicing protein 4 (S. cerevisiae Mrs4p) mitochondrial carrier protein D1046.4 D1046.4 Protein with weak similarity to human sodium-dependent inorganic phosphate cotransporters, member of the major facilitator superfamily sodium/phosphate transporter D1046.5 D1046.5 Protein with strong similarity to C. elegans Y50C1A.2 gene product D1053.1 D1053.1 Protein with high similarity to glutathione transferase zeta 1 (human GSTZ1), which is a maleylacetoacetate isomerase and glutathione peroxidase associated with tyrosinemia, contains glutathione S-transferase N-terminal and C-terminal domains glutathione S-transferase; gst-42 is orthologous to the human gene GLUTATHIONE TRANSFERASE ZETA-1 (also known as MALEYLACETOACETATE ISOMERASE; GSTZ1; OMIM:603758), which when mutated is thought to lead to a variety of type I tyrosinemia. D1053.2 D1053.2 Putative ortholog of C. elegans F54F7.7 gene product D1053.3 D1053.3 Protein of unknown function D1054.1 D1054.1 Protein of unknown function, has moderate similarity to uncharacterized C. elegans B0524.E Human GS2 protein like D1054.10 D1054.10 Protein of unknown function D1054.11 D1054.11 Protein of unknown function D1054.12 D1054.12 Member of the 7-transmembrane chemoreceptor family of G protein-coupled receptors (GPCR), has moderate similarity to uncharacterized C. elegans K08G2.5 D1054.13 D1054.13 Protein of unknown function, has moderate similarity to uncharacterized soluble liver antigen/liver pancreas antigen (human LOC51091) D1054.14 D1054.14 Protein of unknown function, has moderate similarity to uncharacterized human FLJ14936 D1054.15 D1054.15 Protein with high similarity to human PLRG1, which interacts with a nuclear protein kinase C-beta II isoenzyme that is involved in insulin signaling, contains seven WD domain (WD-40 repeat), which may mediate protein-protein interactions beta transducin like protein D1054.2 pas-2;D1054.2 Putative alpha-type subunit of 20S proteasome particle proteasome component C3; pas-2 encodes a proteasome subunit with highest similarity to vertebrate proteasome alpha 2 subunits. D1054.3 D1054.3 Protein of unknown function, has low similarity to a region of S. pombe Git7p, which is involved in glucose-induced cAMP signaling D1054.5 D1054.5 Protein of unknown function D1054.6 D1054.6 Protein with strong similarity to C. elegans F16H6.2 gene product D1054.7 D1054.7 Member of the C-type lectin family, has weak similarity to human C-type mannose receptor MRC1 mannose receptor protein like D1054.8 D1054.8 Member of the short-chain dehydrogenase-reductase family, which are NAD- or NADP-dependent oxidoreductases, has low similarity to mouse H2-Ke6, which is a 17-beta dehydroxysteroid dehydrogenase that is involved in androgen and estrogen metabolism dehydrogenase; This gene encodes a protein predicted by Eisenberg and coworkers, with 68% accuracy, to be mitochondrial. D1054.9 D1054.9 Protein of unknown function D1065.1 D1065.1 Protein of unknown function, has high similarity to uncharacterized C. elegans F45F2.5 D1065.3 D1065.3 Protein containing a WSN domain of unknown function D1065.4 D1065.4 Member of the 7-transmembrane chemoreceptor family of G protein-coupled receptors (GPCR), has high similarity to uncharacterized C. elegans D1065.5 7TM chemoreceptor, srh family D1065.5 D1065.5 Member of the 7-transmembrane chemoreceptor family of G protein-coupled receptors (GPCR), has high similarity to uncharacterized C. elegans D1065.4 7TM chemoreceptor, srh family D1069.1 D1069.1 Protein of unknown function D1069.2 D1069.2 Protein containing a calponin homology (CH) domain, which bind actin, and a calponin family repeat, which consist of a well conserved 26 amino acid domain, has moderate similarity to a region of acidic calponin (rat Cnn3), which binds actin calponin; cpn-2 encodes a calponin homolog, more similar to the calponin paralogs transgelin (SM22 alpha) or neuronal protein NP25 than to calponin per se. D1069.3 D1069.3 Protein of unknown function D1069.4 D1069.4 Protein of unknown function, has moderate similarity to uncharacterized C. elegans Y48A6B.1 D1073.1 D1073.1 Protein containing two protein kinase domains, has a region of low similarity to a region of rat Ntrk3, which is a type 3 neurotrophic receptor protein tyrosine kinase (TrkC) that binds neurotrophin-3 (Ntf3) and may be involved in neuronal apoptosis tyrosine-protein kinase D1079.1 D1079.1 G protein-coupled receptor of unknown function, no homolog found in human or D. melanogaster D1081.2 D1081.2 Protein containing one SRF-type transcription factor (DNA-binding and dimerisation domain) domain, which are involved in transcriptional regulation, has a region of high similarity to a region of serum response factor (human SRF) MADS domain; unc-120 encodes a member of the MADS-box family of transcription factors that contains human and Drosophila serum response factor (SRF) and Saccharomyces cerevisiae MCM1 and ARG80; UNC-120 is required for locomotion and muscle development and for formation of the normal number of muscle A and I bands; UNC-120 is also required for maintaining wild-type expression levels of the muscle components actin and myosin; UNC-120 is first expressed in the early embryo in body wall muscle precursors and later is expressed in both body wall and vulval muscles. D1081.3 D1081.3 Protein with moderate similarity to C. elegans F15H9.1 gene product D1081.4 D1081.4 Protein of unknown function, has a region of moderate similarity to a region of C. albicans Rsr1p, which is a ras-related protein that is required for virulence and for morphogenesis of both yeast-form cells and hyphae guanine nucleotide binding domains D1081.5 D1081.5 Putative ortholog of C. elegans F54H5.5 gene product ankyrin motif D1081.6 D1081.6 Protein of unknown function D1081.7 D1081.7 Protein of unknown function D1081.8 D1081.8;Cdc5Ce Protein with high similarity to CDC5 (cell division cycle 5 S. pombe homolog)-like (human CDC5L), which is a transcriptional activator and non-snRNA spliceosome subunit involved in pre-mRNA splicing, contains two Myb-like DNA-binding domains MYB transforming protein D1081.9 D1081.9 Protein with weak similarity to C. elegans Y39B6.B D1086.1 D1086.1 Protein containing a DUF19 domain of unknown function, which contain twelve conserved cysteines D1086.2 D1086.2 Protein of unknown function D1086.3 D1086.3 Protein containing a DUF19 domain of unknown function, which contain twelve conserved cysteines D1086.4 D1086.4 Protein of unknown function D1086.5 D1086.5 Protein of unknown function, has weak similarity to C. elegans D1086.1 D1086.6 D1086.6 Protein of unknown function, has weak similarity to C. elegans D1086.7 D1086.7 D1086.7 Protein of unknown function, has weak similarity to C. elegans D1086.6 D2005.1 D2005.1 Protein containing one adenosine-deaminase (editase) domain, which deaminate adenosine residues on mRNA, has low similarity to a region of double-stranded RNA adenosine deaminase (rat Adarb1), which is involved in mRNA editing of the glutamate receptor RNA adenosine deaminase like D2005.2 D2005.2 GFxGF neurotransmitter D2005.3 D2005.3 Member of the DUF122 family of unknown function, has high similarity to uncharacterized mouse Pdcd5 D2005.4 D2005.4 Large protein of unknown function, has weak similarity over the C-terminus to a number of S. cerevisiae and C. elegans proteins, has weak similarity to several proteins of the human pathogen Plasmodium falciparum D2005.5 D2005.5 Member of the DEAD or DEAH box ATP-dependent RNA helicase family and contains a helicase conserved C-terminal domain, has a region of weak similarity to a region of C. elegans DCR-1, which is a helicase and RNase RNA helicase like D2005.6 D2005.6 Protein of unknown function D2007.1 D2007.1 Protein of unknown function D2007.2 D2007.2 Protein containing a major sperm protein (MSP) domain, which are involved in sperm motility D2007.2 is orthologous to the human gene TRANSKETOLASE (WERNICKE-KORSAKOFF SYNDROME) (TNF; OMIM:606781), which when mutated leads to disease. D2007.3 D2007.3 Protein of unknown function D2007.4 D2007.4 Possible large ribsomal subunit protein D2007.5 D2007.5 Protein of unknown function, has moderate similarity to H. sapiens Hs.79672 gene product D2013.1 D2013.1 Protein with high similarity to ras-related GTP-binding protein 2 (human RAB2), which is a GTPase that plays a role in vesicle transport from the ER to the Golgi and is associated with Searzy syndrome, member of the Ras superfamily of GTP-binding proteins GTP binding protein (YPT1 subfamily); rab-39 encodes a small, monomeric Rab GTPase that is most closely related to the human and Drosophila Rab39 GTPases; by homology, RAB-39 is predicted to function as a membrane-associated GTPase required for intracellular vesicular trafficking and for regulation of endo- and exocytosis; however, as loss of rab-39 function via RNA-mediated interference (RNAi) does not result in any obvious abnormalities, the precise role of RAB-39 in C. elegans development and/or behavior is not yet known. D2013.10 D2013.10 Protein of unknown function, has low similarity to uncharacterized human MGC15397 D2013.2 D2013.2 Protein containing five WD domains (WD-40 repeat), which may mediate protein-protein interactions, and a FYVE zinc finger domain, which bind phosphatidylinositol 3-phosphate, has moderate similarity to uncharacterized human WDF2 beta-transducin D2013.3 D2013.3 Protein containing three WD domains (WD-40 repeat), which may mediate protein-protein interactions D2013.4 cam-1;kin-8;Cehd-17;C01G6.8;D2013.4 Putative receptor tyrosine protein kinase, member of the ROR family of tyrosine receptor kinases of unknown function D2013.5 D2013.5 Protein containing an N-terminal dynamin family domain, which bind GTP, has a region of low similarity to a region of S. cerevisiae Mgm1p, which is a peripheral membrane protein that mediates mitochondrial inheritance GTP-binding protein; The eat-3 gene encodes a mitochondrial dynamin-related protein, closely related to bacterial dynamin-like proteins, that is orthologous to human OPA1 (OMIM:203740, mutated in autosomal dominant optic atrophy); EAT-3 is localized to the mitochondrial matrix and may play a role in regulating inner mitochondrial membrane morphology; EAT-3 is expressed in body wall muscle, intestine, and neurons, all tissues with high metabolic rates. D2013.6 D2013.6 Protein containing a GRAM domain, which are found in glucosyltransferases, myotubularins and other putative membrane-associated proteins, has low similarity to WW domain binding protein 2 (mouse Wbp2), which is a ligand involved in protein binding D2013.7 D2013.7 Protein with strong similarity to human eukaryotic translation initiation factor 3, subunit 5 (EIF3S5) M0V-34 protein D2013.8 scp-1;D2013.8 Protein containing four WD domains (WD-40 repeat), which may mediate protein-protein interactions, has low similarity to a region of SREBP cleavage-activating protein (human SCAP), which regulates cholesterol metabolism scp-1 encodes PTC-related protein that contains a sterol-sensing domain related to human Sterol regulatory element binding protein (SREBP) cleavage activating protein. D2013.9 D2013.9 Member of the tubulin-tyrosine ligase family, has low similarity to uncharacterized human KIAA0153 D2021.1 D2021.1 Protein containing five TPR (tetratrico peptide repeat) domains, which may mediate protein-protein interactions, and a Jumonji (jmjC) domain, has a region of weak similarity to ubiquitous tetratricopeptide repeat protein on the Y chromosome (human UTY) glucose repression mediator protein D2021.2 D2021.2 Protein containing a DHHC-type zinc finger (NEW1) domain, has a region of low similarity to a region of huntingtin interacting protein H (human HYPH), which interacts with human HD and this interaction may be altered in Huntington's disease D2021.4 D2021.4 Protein of unknown function D2021.8 D2021.8 Protein containing five ankyrin (Ank) repeats, which may mediate protein-protein interactions, has low similarity to prosome (human PSMD10, macropain), which is a non-ATPase subunit of the 26S proteasome ankyrin D2023.1 D2023.1 Protein containing one heme-binding domain, has a region of moderate similarity to a region of mitochondrial outer membrane ferrocytochrome b5 (rat Omb5), which is a heme binding protein that carrys out electron transfer reactions D2023.2 pyc-1;D2023.2 Protein with high similarity to pyruvate carboxylase 1 (S. cerevisiae Pyc1p), contains biotin or lipoyl attachment and biotin carboxylase C-terminal domains, carbamoyl-phosphate synthase L chain ATP binding and N-terminal domains, and an HMGL-like domain pyruvate carboxylase; pyc-1 encodes the C. elegans pyruvate carboxylase ortholog (OMIM:266150, deficiencies in humans are associated with lactic acidemia, neurological abnormalities, and early death); by homology, PYC-1 is predicted to function as a key regulatory enzyme of gluconeogenesis, lipogenesis, and anaplerosis, localizing to the mitochondrial matrix and catalyzing the formation of oxaloacetate from pyruvate and carbonate; however, loss of pyc-1 activity via large-scale RNAi screens does not result in any obvious abnormalities; pyc-1 expression is induced upon exposure of C. elegans to cadmium. D2023.3 D2023.3 Putative calcium-binding protein, has weak similarity to human SYT7 (rat synaptotagmin VII homolog) D2023.4 D2023.4 Protein containing an acetyltransferase (GNAT) domain, has low similarity to spermidine-spermine N1-acetyltransferase (mouse Sat), which catalyzes the rate limiting step of polyamine catabolism and promotes polyamine homeostasis diamine acetyltransferase D2023.5 D2023.5 Protein with low similarity to thiosulfate sulfotransferase (rhodanese, human TST), which is a thiosulfate sulfotransferase enzyme that functions in detoxification of cyanide thiosulphate sulphurtransferase D2023.6 D2023.6 Protein with moderate similarity to S. cerevisiae Abc1p, a possible chaperonin for the assembly of cytochrome bc1 complex Yeast ABC1 protein like; This gene encodes a protein predicted by Eisenberg and coworkers, with 52% accuracy, to be mitochondrial. D2023.7 D2023.7 Protein with high similarity to C. elegans ROL-6, which is involved in cuticle synthesis, contains two collagen triple helix repeats, which are found in some extracellular proteins, and a nematode cuticle collagen N-terminal domain collagen D2024.1 D2024.1 Protein containing a protein kinase domain, has low similarity to casein kinase 1 epsilon (human CSNK1E), which is a serine/threonine protein kinase that may function in DNA repair and is associated with familial advanced sleep phase syndrome D2024.2 D2024.2 Protein of unknown function, has moderate similarity to uncharacterized C. elegans Y45F10A.3 D2024.3 D2024.3 Member of the GNS1 or SUR4 family of integral membrane proteins, has a region of moderate similarity to polyunsaturated fatty acid (PUFA) elongase (C. elegans CEEl01), which contains the condensation activity required for fatty acid elongation The elo-3 gene encodes a paralog of elo-1 and elo-2, each of which encodes a polyunsaturated fatty acid (PUFA) elongase; ELO-3 may be required for normally rapid growth. D2024.4 D2024.4 Protein of unknown function D2024.5 D2024.5 Protein of unknown function D2024.6 cap-1;D2024.6 Protein with high similarity to capping protein muscle Z-line alpha 1 (human CAPZA1), which regulates actin polymerization and may contribute to barbed-end actin capping and cell motility, member of the F-actin capping protein alpha subunit family cap-1 encodes an F-actin capping protein alpha subunit that affects fertility; likely expressed in touch receptor neurons. D2024.7 D2024.7 Member of the 2-hydroxychromene-2-carboxylate isomerase protein family, which are involved in prokaryotic polyaromatic hydrocarbon (PAH) catabolism, has low similarity to uncharacterized C. elegans ZK1320.1 D2024.8 D2024.8 Protein containing two collagen triple helix repeats, which are found in some extracellular proteins, and a nematode cuticle collagen N-terminal domain, has a region of moderate similarity to a region of collagen type IX alpha 3 (human COL9A3) cuticle collagen D2024.9 D2024.9 Protein with strong similarity to C. elegans F35E8.5 gene product D2030.1 D2030.1 Protein with high similarity to mannosidase 1 alpha (mouse Man1a), which trims mannose residues and plays a role in misfolded protein degradation, member of the glycosyl hydrolase 47 family of alpha-mannosidases, which hydrolyze terminal mannose residues alpha 1,2 mannosidase precursor D2030.10 aex-1;D2030.10 Protein of unknown function AEX-1 is a novel C2 domain protein; C2 is a proposed calcium binding domain; AEX-1 is weakly similar to the rat protein Munc13, which regulates vesicle exocytosis; AEX-1 regulates UNC-13 localization; mutation of dgk-1, or a gain-of-function mutation of egl-30, suppresses the aex-1 mutant phenotype. D2030.2 D2030.2 Member of the ATPase family associated with various cellular activities, has moderate similarity to caseinolytic protease X (human CLPX), which may be involved in mitochondrial protein homeostasis and function as a tissue-specific mitochondrial chaperone ATP-dependent CLP protease (CLPX) like; This gene encodes a protein predicted by Eisenberg and coworkers, with 52% accuracy, to be mitochondrial. D2030.3 D2030.3 Protein of unknown function D2030.4 D2030.4 Protein with high similarity to human NDUFB7, which is a subunit of the NADH-ubiquinone oxidoreductase complex I and may function as a cell adhesion molecule and metastasis NADH:CoQ oxidoreductase subunit B18 D2030.5 D2030.5 Member of the glyoxalase, bleomycin resistance or dioxygenase superfamily, which are involved in the glyoxal pathway, has high similarity to uncharacterized methylmalonyl CoA epimerase (human MCEE) B.subtilis YQJC protein like D2030.6 prg-1;D2030.6 PIWI-related protein required for wild-type levels of germ-line proliferation D2030.7 D2030.7 Protein of unknown function Zinc finger, C3HC4 type (RING finger) D2030.8 D2030.8 Protein of unknown function D2030.9 D2030.9 Protein containing twelve WD domains (WD-40 repeat), which may mediate protein-protein interactions, has a region of low similarity to a region of human HPRP8BP, which is a U5 snRNP-specific protein that may function in mRNA splicing Lithosperm lec14B protein like D2045.1 atx-2;D2045.1 Proline- and glutamine-rich protein; weakly similar to human proteins containing CAG repeats (glutamine-rich); required for embryogenesis in C. elegans atx-2 is required for early embryonic patterning; it encodes an ortholog of human ataxin-2, which when mutated leads to spinocerebellar ataxia 2 (SCA2; OMIM:183090). D2045.2 D2045.2 Member of the cell wall biogenesis Ecm29p-like protein family D2045.5 D2045.5 Protein containing a protein kinase domain, has low similarity to casein kinase 1 alpha 1 (human CSNK1A1), which is a serine-threonine protein kinase that may be associated with Alzheimer's disease serine/threonine kinase D2045.6 cul-1;lin-19;D2045.6 Cell cycle control protein, member of the cullin family of cell cycle control proteins Cuticlin family; cul-1 encodes a cullin, orthologous to Cdc53/Cul1 in S. cerevisiae and CUL-1 in humans (OMIM:603134), that is required both maternally and zygotically for developmentally programmed transitions from the G1 phase of the cell cycle to the GO phase or the apoptotic pathway, and that is probably also required for normally slow G1-to-S phase progression; CUL-1 physically interacts with eight Skp1-related proteins (SKR-1, -2, -3, -4, -7, -8, -9, and -10). D2045.7 D2045.7 Serine/threonine protein kinase with similarity to human myristoylated and palmitoylated protein kinase MPSK1, has similarity to D. melanogaster cAMP-dependent protein kinase serine/threonine kinase D2045.8 D2045.8 Protein containing a K+ channel tetramerization domain, which facilitate assembly of alpha-subunits into functional tetrameric channels, has moderate similarity to uncharacterized C. elegans C40A11.6 TNF-alpha induced Protein B12 D2045.9 D2045.9 Member of the glycosyltransferase family 25 or LPS biosynthesis protein family, which are involved in lipopolysaccharide biosynthesis, has a region of moderate similarity to a region of cerebral cell adhesion molecule (human LOC51148) D2062.1 D2062.1 Protein of unknown function, has low similarity to a region of C. albicans Rbt4p, which is required for full virulence, is expressed specifically during hyphal growth, and is transcriptionally regulated by C. albicans Tup1p and C. albicans Efg1p D2062.2 D2062.2 Member of the 7-transmembrane chemoreceptor family of G protein-coupled receptors (GPCR), has moderate similarity to uncharacterized C. elegans Y27F2A.3 7TM chemoreceptor, sri family D2062.3 D2062.3 Member of the 7-transmembrane chemoreceptor family of G protein-coupled receptors (GPCR), has high similarity to uncharacterized C. elegans C14C6.10 7TM chemoreceptor, sri family D2062.4 D2062.4 Protein of unknown function, has high similarity to uncharacterized C. elegans D2062.5 D2062.5 D2062.5 Protein of unknown function, has high similarity to uncharacterized C. elegans D2062.4 D2062.6 D2062.6 Protein of unknown function, has high similarity to uncharacterized C. elegans F46F5.6 D2062.7 D2062.7 Protein of unknown function, has moderate similarity to C. elegans D2062.6 D2062.8 D2062.8 Member of the 7-transmembrane chemoreceptor family of G protein-coupled receptors (GPCR), has very strong similarity to uncharacterized C. elegans SRI-39 7TM chemoreceptor, sri family D2062.9 D2062.9 Member of the 7-transmembrane chemoreceptor family of G protein-coupled receptors (GPCR), has high similarity to uncharacterized C. elegans SRI-74 7TM chemoreceptor, sri family D2063.A D2063.3;D2063.A Protein of unknown function, has a region of moderate similarity to glutaredoxin (S. cerevisiae Grx4p), which is involved in the oxidative stress response D2063.B D2063.2;D2063.B Protein containing a DUF33 domain of unknown function, has high similarity to uncharacterized C. elegans K09E10.2 D2063.E D2063.1;D2063.E Member of the zinc-containing alcohol dehydrogenase family, which catalyze reversible oxidation of ethanol to acetaldehyde, has moderate similarity to alcohol dehydrogenase I (C. albicans Adh1p), which may function as an extracellular matrix adhesin D2085.1 D2085.1 Protein with high similarity to carbamoylphosphate synthetase 2-aspartate transcarbamylase-dihydroorotase (human CAD), which is involved in pyrimidine biosynthesis, member of the dihydroorotase-like and glutamine amidotransferase class I families glutamine-dependent carbamoyl-phosphate synthase, aspartate carbamoyltransferase, dihydroorotase; pyr-1 is orthologous to the human gene CARBAMYL PHOSPHATE SYNTHETASE I (CPS1, which when mutated leads to hyperammonemia (OMIM:237300); PYR-1 protein is predicted to be mitochondrial with 68% accuracy. D2085.2 D2085.2 Protein of unknown function, has weak similarity to C. elegans D2085.7 D2085.3 D2085.3 Protein containing 2 bacterial transferase hexapeptide domains and a eukaryotic translation initation factor W2 domain, has low similarity to translation initiation factor 2B subunit 5 (epsilon) (rat eIF-2Be), which is a guanyl-nucleotide exchange factor translation initiation factor (EIF); D2085.3 is orthologous to the human gene UNKNOWN (PROTEIN FOR MGC:9947) (EIF2B5; OMIM:603945), which when mutated leads to disease. D2085.4 D2085.4 Protein containing a HECT domain, which may confer ubiquitin-protein ligase activity, and an IQ calmodulin-binding domain, has a region of low similarity to a region of S. pombe Pub1p, which is a ubiquitin ligase similarity with a human hypothetical protein (PIR Acc. No. A38919) D2085.5 D2085.5 Protein of unknown function D2085.6 D2085.6 Protein with high similarity to GPI GlcNAc transferase a (mouse Piga), which is a subunit of the alpha 1 6 N acetylglucosaminyltransferase complex and acts in the biosynthesis of GPI anchors, member of the glycosyl transferases group 1 family phosphatidylinositol biosynthetic protein; D2085.6 is orthologous to the human gene CLASS A GLCNAC-INOSITOL PHOSPHOLIPID ASSEMBLY PROTEIN (PIGA; OMIM:311770), which when mutated leads to paroxysmal nocturnal hemoglobinuria. D2085.7 D2085.7 Protein of unknown function, has weak similarity to C. elegans D2085.2 D2089.1 D2089.1;Cep54;rsp-7 An SR protein, thought to be involved in mRNA splicing RNA binding protein D2089.2 D2089.2 Protein of unknown function, contains a short region with similarity to S. cerevisiae Ssm4p (involved in mRNA turnover) D2089.3 D2089.3 Protein of unknown function D2089.4 D2089.4;CePTB;ptb-1 Putative heterogeneous nuclear ribonucleoprotein (hnRNP), has strong similarity to human polypyrimidine tract binding protein (heterogeneous nuclear ribonucleoprotein I, PTB) and Drosophila SMOOTH (sm) (see BLAST); an SR-like protein polypyrimidine tract binding protein D2089.5 D2089.5 Protein with moderate similarity to gamma-butyrobetaine hydroxylase (rat Bbox), which catalyzes the conversion of gamma butyrobetaine to carnitine gamma-butyrobetaine,2-oxoglutarate dioxygenase; gbh-1 encodes a predicted ortholog of human hBBOX1; expressed in the intestine and in head and body muscles. D2092.1 D2092.1 Protein containing six C2 domains, which may be involved in calcium-dependent phospholipid binding C2 domain-containing protein D2092.2 D2092.2 Protein of unknown function D2092.3 acr-11;D2092.3 Protein with high similarity to C. elegans ACR-16, which is a nicotinic acetylcholine receptor alpha-1 subunit, contains neurotransmitter-gated ion-channel ligand binding and transmembrane domains ligand-gated ionic channel protein; A homolog of an alpha type nicotinic acetylcholine receptor subunit involved in the mediation of fast synaptic transmission at neuromuscular junctions. D2092.4 D2092.4 Protein of unknown function, has weak similarity to human PDIR, protein disulfide isomerase-related protein D2092.5 D2092.5 Protein of unknown function, has weak similarity to uncharacterized human FLJ10747 D2092.6 D2092.6 Protein of unknown function D2092.7 D2092.7 Member of the tetraspanin family, which contain an N-terminal transmembrane domain that is a signal sequence and membrane anchor transpanin D2092.8 D2092.8 Protein of unknown function D2096.1 D2096.1 Member of the mitochondrial import inner membrane translocase subunit Tim17, has a region of high similarity to a region of mitochondrial inner membrane translocase subunit 17b (human TIMM17B), which is involved in mitochondrial translocation D2096.10 D2096.10 Protein of unknown function, has moderate similarity to uncharacterized C. elegans F17E9.4 D2096.2 D2096.2 Protein with moderate similarity to glutamate transporter EAAC1-interacting protein (rat Gtrap3-18), which binds to the intracellular region of the excitatory glutamate carrier EAAC1 (Slc1a1) thus reducing the affinity for and transport of glutamate D2096.3 D2096.3 Member of the glycosyl hydrolases family 31, which are involved in carbohydrate metabolism, contains a P-type trefoil domain, has a region of moderate similarity to a region of maltase-glucoamylase (mucosal glucoamylase, human MGAM), which digests starch D2096.4 D2096.4 Member of the NAD-dependent epimerase or dehydratase family, which catalyze reactions involving nucleotide sugar substrates, has a region of high similarity to UDP-glucuronate decarboxylase (C. neoformans Uxs1_D) sqv-1 encodes a UDP-glucuronic acid decarboxylase, biochemically active in vitro, that is required for cytokinesis of one-cell embryos and for vulval morphogenesis; SQV-1 is coexpressed with the nucleotide-sugar transporter homolog SQV-7 in in the vulva and in oocytes; SQV-1 colocalizes with SQV-5 and SQV-7 to punctate foci (probably the Golgi apparatus) in the cytoplasm of the vulva, the uterus and oocytes, within which SQV-1 may act to promote the biosynthesis of chondroitin glycosaminoglycans; the common requirement for SQV-1 in both cytokinesis and morphogenesis may be to promote filling an extracellular space with hygroscopic proteoglycans (either in the eggshell, or underneath the L4 cuticle), which in turn may cause the space to fill with fluid. D2096.5 D2096.5 Protein of unknown function, has weak similarity to C. elegans T26A8.3 D2096.6 myo2-D;D2096.6 Protein of unknown function, has high similarity to uncharacterized C. elegans T25E4.1 D2096.7 D2096.7 Protein of unknown function D2096.8 D2096.8 Member of the nucleosome assembly protein (NAP) family, has moderate similarity to nucleosome assembly protein 1-like 4 (human NAP1L4), which is a histone chaperone that acts in the transfer of core and linker histones to DNA and in nucleosome assembly D2096.9 D2096.9 Protein with moderate similarity to C. elegans K09C6.3 gene product DC2.1 DC2.1 Protein of unknown function, putative paralog of C. elegans W03F9.6, C04F2.1, and F09G2.7 7TM chemoreceptor, srh family DC2.2 DC2.2 Protein of unknown function, putative paralog of C. elegans C04F2.1 and W03F9.6 7TM chemoreceptor, srh family DC2.3 DC2.3 DC2.3 Protein with similarity over the C-terminus to human and C. elegans galactoside-binding lectins galactoside-binding lectin DC2.4 DC2.4 Protein of unknown function DC2.5 DC2.5 Protein with similarity to alcohol and other short chain dehydrogenases, putative paralog of C. elegans E04F6.7 dehydrogenase; This gene encodes a protein predicted by Eisenberg and coworkers, with 52% accuracy, to be mitochondrial. DC2.6 DC2.6 Protein of unknown function, putative paralog of C. elegans C04F2.1 and W03F9.6 7TM chemoreceptor, srh family DC2.7 DC2.7 Protein containing a putative eukaryotic protein kinase domain protein kinase DH11.1 DH11.1 Member of the ank repeat protein family glutaminase DH11.2 DH11.2 Protein of unknown function DH11.3 DH11.3 Member of the ABC transporter family, contains two ABC transporter transmembrane domains, has low similarity to C. elegans PGP-3, which is a P-glycoprotein of intestinal cells that acts as a multidrug resistance protein multidrug resistance protein; pgp-11 encodes a transmembrane protein that is a member of the P-glycoprotein subclass of the ATP-binding cassette (ABC) transporter superfamily; by homology, PGP-11 is predicted to function as an ATP-dependent efflux pump that protects C. elegans by exporting exogenous toxins; however, as loss of pgp-11 activity via large-scale RNAi screens does not result in any obvious abnormalities, the precise role of PGP-11 in C. elegans development and/or behavior is not yet known. DH11.4 DH11.4 Protein with weak similarity to C. elegans C08G5.4 gene product synaptotagamin carboxyl terminus DH11.5 DH11.5 Protein of unknown function DUR91 dur91 Dauer-upregulated protein 191 DY3.1 DY3.1 Protein containing a Tim10 or DDP family zinc finger domain, has a region of high similarity to translocase of the mitochondrial inner membrane 13 (human TIMM13A), which is a mitochondrial translocase subunit DY3.2 lmn-1;lam-1;DY3.2 Nuclear type-B lamin ortholog; required for normal cell cycle progression and chromatin organization Intermediate filament proteins (2 domains); The lmn-1 gene encodes a nuclear lamin; LMN-1 protein is essential for the nuclear envelope localization of emerin (EMR-1) protein during during early development. DY3.3 DY3.3 Protein containing one helix-loop-helix DNA-binding domain, which mediate protein dimerization Helix-loop-helix DNA-binding domain DY3.4 CeTERT;DY3.4 Member of the reverse transcriptase family, which are RNA-dependent DNA polymerases Reverse transcriptase (RNA-dependent DNA polymerase); trt-1 encodes C. elegans telomerase reverse transcriptase that affects fertility, maintenance of telomere length, and chromosome nondisjunction. DY3.5 DY3.5 Protein of unknown function, contains a coiled-coil region, has weak similarity to C. elegans ZC334.5, has weak similarity over the C-terminus to human REST (RE1-silencing transcription factor) The protein product of this gene is predicted to contain a glutamine/asparagine (Q/N)-rich ('prion') domain, by the algorithm of Michelitsch and Weissman (as of the WS77 release of WormBase, i.e., in wormpep77). DY3.6 DY3.6 Protein containing an F-box domain, which serve as a link between a target protein and a ubiquitin-conjugating enzyme, has low similarity to uncharacterized f-box only protein 32 (human FBXO32) This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins. DY3.7 sup-17;DY3.7 Transmembrane disintegrin/metalloprotease of the ADAM family Zinc-binding metalloprotease domain; sup-17 encodes an ADAM protein, an integral membrane disintegrin and zinc-activated metalloproteinase, orthologous to Drosophila and mouse KUZBANIAN and the vertebrate ADAM10 proteins; SUP-17 is required maternally for embryonic development and plays a role in LIN-12/Notch-mediated cell signaling required for several cell fate decisions during vulval development; SUP-17 is also required for normal body morphology and male tail development; SUP-17 functions cell autonomously to facilitate LIN-12 signaling and requires the LIN-12 extracellular domain to do so. E01A2.1 E01A2.1 Protein with moderate similarity to H. sapiens GLCLR (glutamate-cysteine ligase (gamma-glutamylcysteine synthetase), regulatory (30.8kD)) E01A2.2 E01A2.2 Putative ortholog of D. melanogaster CG7843 (CG7843 gene product) E01A2.4 E01A2.4 Protein with moderate similarity to D. melanogaster CG6066 (CG6066 gene product) E01A2.5 E01A2.5 Protein with strong similarity to D. melanogaster CG1578 (CG1578 gene product) E01A2.6 E01A2.6 Protein with weak similarity to D. melanogaster CG8580 (CG8580 gene product) E01A2.7 E01A2.7 Putative paralog of C. elegans E01A2.8 The E01A2.7 gene encodes one of five paraoxonase-like proteins; it is homologous to the human genes PARAOXONASE 1 gene (PON1, OMIM:168820) and PARAOXONASE 2 (OMIM:602447), which in some allelic forms are associated with susceptibility to coronary artery disease or to variations in fasting plasma glucose. E01A2.8 E01A2.8 Putative paralog of C. elegans E01A2.7 The E01A2.8 gene encodes one of five paraoxonase-like proteins; it is homologous to the human PARAOXONASE 1 gene (PON1, OMIM:168820), which in some allelic forms is associated with susceptibility to coronary artery disease. E01A2.G lin-44;E01A2.3;E01A2.G Protein with strong similarity to H. sapiens WNT2 gene product E01B7.1 E01B7.1 Protein of unknown function, has low similarity to a region of ubiquitin specific protease 8 (human USP8), which is a deubiquitinating enzyme that plays a role in proliferation and cell cycle control E01B7.2 E01B7.2 Protein of unknown function, putative paralog of C. elegans C06H5.4 E01F3.1 E01F3.1 Member of the 3',5'-cyclic nucleotide phosphodiesterase family, has moderate similarity to a region of cGMP inhibited phosphodiesterase 3A (human PDE3A), which hydrolyzes cAMP to AMP and may be associated with obesity and diabetes mellitus type II 3'5'-cyclic nucleotide phosphodiesterases E01G4.1 E01G4.1 Protein with weak similarity over C-terminal half to S. cerevisiae GTPase-activating protein, GYP7; contains a coiled-coil region E01G4.2 E01G4.2 Protein containing a MIF4G (middle domain of eukaryotic initiation factor 4G) domain E01G4.3 E01G4.3 Protein of unknown function E01G4.4 E01G4.4 Protein of unknown function The protein product of this gene is predicted to contain a glutamine/asparagine (Q/N)-rich ('prion') domain, by the algorithm of Michelitsch and Weissman (as of the WS77 release of WormBase, i.e., in wormpep77). E01G4.5 E01G4.5 Putative ortholog of C. elegans Y116F11.Y gene product E01G4.6 E01G4.6 Putative coiled-coil protein, has weak similarity to myosin heavy chains E01G6.1 E01G6.1 Protein containing three kunitz or bovine pancreatic trypsin inhibitor domains and an EB module domain, has a region of low similarity to tissue factor pathway inhibitor (human TFPI), which is a protease inhibitor that prevents fibrin clot formation pancreatic trypsin inhibitor (kunitz) protein E01G6.2 E01G6.2 Protein of unknown function E01G6.3 E01G6.3 Protein with strong similarity to esterases, putative paralog of C. elegans C23H4.2 serine esterase E01H11.1 kin-11;pkc-2;PKC2;E01H11.1 Serine/threonine protein kinase with strong similarity to human, D. melanogaster, and S. cerevisiae protein kinase C isoforms Protein kinase C; pkc-2 is orthologous to the human gene PROTEIN KINASE C ALPHA (AA 1-672) (PRKCA; OMIM:176960), which when mutated leads to disease. E01H11.2 E01H11.2 Protein of unknown function E01H11.3 E01H11.3 Protein of unknown function flp-20 encodes two copies of a single FMRFamide-related short peptide neurotransmitter; the precise role of this peptide in C. elegans neurotransmission is not yet known. E02A10.1 E02A10.1 Member of the ribosomal S5 protein family mitochondrial 40S ribosomal protein S5; This gene encodes a protein predicted by Eisenberg and coworkers, with 68% accuracy, to be mitochondrial. E02A10.2 E02A10.2 Putative coiled-coil protein, has similarity in the C-terminus to the coiled-coil domain of human GOLGA4 (golgi autoantigen, golgin subfamily) E02A10.3 E02A10.3 Protein containing four EF hand domains, has moderate similarity to calmodulin 1 (phosphorylase kinase, delta, rat Calm1), which is a neuronal cell protein that binds calcium calmodulin-like protein E02C12.10 E02C12.10 Protein containing a DUF227 domain of unknown function E02C12.11 E02C12.11 Protein with strong similarity to C. elegans E02C12.10 gene product E02C12.12 E02C12.12 Putative ortholog of C. elegans E02C12.10 gene product E02C12.2 E02C12.2 Protein of unknown function, has high similarity to uncharacterized C. elegans E02C12.3, which is predicted to be a G protein-coupled receptor 7TM chemoreceptor, srx family E02C12.3 E02C12.3 Protein of unknown function, has high similarity to uncharacterized C. elegans E02C12.2, which is predicted to be a G protein-coupled receptor 7TM chemoreceptor, srx family E02C12.4 E02C12.4 Member of the transthyretin-like family, has low similarity to uncharacterized C. elegans F22A3.2 E02C12.5 gpa-3;gba-3;E02C12.5 Member of the G protein alpha subunit family guanine nucleotide-binding protein; gpa-3 encodes a member of the G protein alpha subunit family of heterotrimeric GTPases that affects dauer formation, water-soluble chemoattraction and chemoaversion, and volatile chemoattraction; it is expressed in amphid and phasmid neurons and some interneurons. E02C12.6 E02C12.6 Protein containing a DUF227 domain of unknown function, has high similarity to uncharacterized C. elegans Y45G12C.4 E02C12.7 E02C12.7 Protein containing a DUF227 domain of unknown function, has high similarity to uncharacterized C. elegans E02C12.9 E02C12.8 E02C12.8 Protein of unknown function, has strong similarity to C. elegans E02C12.10 E02C12.9 E02C12.9 Protein containing a DUF227 domain of unknown function, has high similarity to uncharacterized C. elegans E02C12.7 E02D9.1 E02D9.1 Protein containing two protein kinase domains, has a region of low similarity to a region of MAP kinase kinase 5 (mouse Map2k5), which may participate in mitogenic signaling pathways and is a positive modulator of cell proliferation protein kinase E02D9.2 E02D9.2 Protein of unknown function E02H1.1 E02H1.1 Protein with high similarity to dimethyladenosine transferase (rRNA (adenine-N6,N6-)-dimethyltransferase, S. cerevisiae Dim1p), which is responsible for dimethylation of 18S rRNA 3'-terminal loop, member of the ribosomal RNA adenine dimethylases family rRNA methyltransferase E02H1.2 E02H1.2 Protein of unknown function, has low similarity to uncharacterized Era-like 1 (mouse Eral1), which is a putative GTPase with possible roles in cell cycle control GTP binding protein; This gene encodes a protein predicted by Eisenberg and coworkers, with 68% accuracy, to be mitochondrial. E02H1.3 E02H1.3 Member of the tRNA pseudouridine synthase family, has low similarity to S. cerevisiae Deg1p, which is a pseudouridine synthase that catalyzes the formation of pseudouridine-38 and -39 in cytoplasmic and mitochondrial tRNAs Yeast DEG-1 protein homolog; This gene encodes a protein predicted by Eisenberg and coworkers, with 68% accuracy, to be mitochondrial. E02H1.4 E02H1.4 Protein containing a poly(ADP-ribose) polymerase catalytic domain and a poly(ADP-ribose) polymerase regulatory domain, has low similarity to poly (ADP ribose) polymerase 2 (mouse Adprt2), which binds to damaged DNA and is involved in genome protection ADP-Ribosyltransferase E02H1.5 E02H1.5 Protein of unknown function, has low similarity to uncharacterized human LOC51637 E02H1.6 E02H1.6 Protein with high similarity to S. cerevisiae Fap7p, which is an essential protein important for Skn7p-dependent transcription of target genes during oxidative stress ATP binding protein E02H1.7 nhr-19;E02H1.7 Protein containing two nuclear hormone receptor C4-type zinc finger domains and two nuclear hormone receptor ligand-binding domains, has low similarity to hepatocyte nuclear factor 4 gamma (human HNF4G), which is involved in transcriptional regulation Zinc finger, C4 type (two domains) E02H4.1 del-1;E02H4.1 Member of the amiloride-sensitive sodium channel family, has similarity to H. sapiens and D. melanogaster amiloride-sensitive cation channels mechanosensory protein; del-1 encodes an ion channel protein of the DEG/ENaC (degenerin/epithelial Na+ channel) family; like other members of the degenerin family, DEL-1 is predicted to function as a sensory mechanotransduction channel, however detailed analysis of the DEL-1 mutant phenotype has not yet been reported; DEL-1 is expressed postembryonically in the VA and VB motor neurons and in the FLP sensory neurons; the DEL-1 expression pattern overlaps that of UNC-8, an additional C. elegans degenerin involved in movement control, with which DEL-1 may coassemble to form mechanically activated cation channels. E02H4.2 E02H4.2 Protein of unknown function E02H4.3 E02H4.3 Protein containing a protein kinase domain, has a region of high similarity to CDC-like kinase 2 (human CLK2), which is a dual specificity protein kinase that associates with serine- and arginine-rich (SR) proteins and may thus regulate mRNA splicing serine/threonine kinase (CLK subfamily) E02H4.4 E02H4.4 Putative ortholog of C. elegans K06G5.1 gene product E02H4.5 E02H4.5 Protein of unknown function E02H4.6 E02H4.6 Protein containing a protein kinase domain, has high similarity to uncharacterized C. elegans K04C1.5 serine/threonine kinase E02H9.1 E02H9.1 Protein with moderate similarity to C. elegans E02H9.9 gene product E02H9.2 E02H9.2 Protein with strong similarity to C. elegans C49A9.4 gene product E02H9.3 E02H9.3 Putative ortholog of C. elegans C49A9.9 gene product E02H9.4 E02H9.4 Protein of unknown function, has moderate similarity to C. elegans C49A9.1 E02H9.5 E02H9.5 Member of the glycosyl hydrolases family 1, which may be involved in carbohydrate metabolism, has moderate similarity to a region of lactase-phlorizin hydrolase (human LCT), which is a lactase and phloridzin hydrolase associated with adult hypolactasia glycosyl hydrolase; E02H9.5 is orthologous to the human gene LPH PREPRO-POLYPEPTIDE (AA -19 TO 1908) (LCT; OMIM:603202), which when mutated leads to disease. E02H9.6 E02H9.6 Putative ortholog of C. elegans W04B5.6 gene product E02H9.7 E02H9.7 Protein of unknown function, has weak similarity to C. elegans E02H9.2 E02H9.8 E02H9.8 Protein containing nuclear hormone receptor C4-type zinc finger and ligand-binding domains, has low similarity to C. elegans NHR-80, which is involved in embryogenesis and morphogenesis E02H9.9 E02H9.9 Protein with moderate similarity to C. elegans E02H9.1 gene product E03A3.2 E03A3.2 Member of the RECQ family of helicases DNA helicase E03A3.3 E03A3.3 Protein with strong similarity to H3 histone family 3A (mouse H3f3a), which is expressed independently of DNA replication and is required for normal growth rates and male fertility, member of the histone family of nucleosomal core proteins histone H3; his-69 encodes a truncated H3 histone. E03A3.4 E03A3.4 Protein with high similarity to H3 histone family 3A (mouse H3f3a), which is expressed independently of DNA replication and is required for normal growth rates and male fertility, member of the histone family of nucleosomal core proteins histone H3; his-70 encodes an H3 histone. E03A3.5 E03A3.5 Protein containing two CUB domains, has a region of low similarity to a region of cubilin (intrinsic factor-cobalamin receptor, rat Cubn), which is a receptor for vitamin B12 and intrinsic factor and plays a role in receptor mediated endocytosis disulphide bond domain E03A3.6 E03A3.6 Protein of unknown function A novel protein involved in responsiveness to volatile anesthetics; it is expressed primarily in the nervous system. E03A3.7 E03A3.7 Protein of unknown function E03A3.8 C03C10.7;E03A3.8 Protein of unknown function E03D2.1 E03D2.1 MSFamide neurotransmitter neuropeptide; nlp-13 encodes a predicted neuropeptide of the MSFamide family; expressed primarily in neurons or in the endocrine/secretory cells, and expression includes pharyngeal neurons that modulate pharyngeal pumping of food. E03D2.2 E03D2.2 GGARAF neurotrasmitter E03D2.3 E03D2.3 Member of the 7-transmembrane chemoreceptor family of G protein-coupled receptors (GPCR), has high similarity to uncharacterized C. elegans Y68A4A.1 7TM chemoreceptor, srh family E03D2.4 E03D2.4 Protein containing a DUF32 domain of unknown function, has high similarity to uncharacterized C. elegans ZC142.1 7TM chemoreceptor, srt family E03E2.1 E03E2.1 Member of the cytochrome P450 family, has low similarity to cytochrome P450 subfamily 3A polypeptide 43 (human CYP3A43), which has low testosterone hydroxylase activity cytochrome P450 E03G2.1 E03G2.1 Protein with moderate similarity to C. elegans F31B9.3 gene product E03G2.2 E03G2.2 Member of the ABC transporter family, contains two ABC transporter transmembrane domains, has moderate similarity to ATP-binding cassette subfamily C member 1a (mouse Abcc1a), which is an ATP-binding cassette transporter multidrug resistance-associated protein E03G2.3 mec-5;E03G2.3 Collagen of the collagen triple helix repeat (20 Copies) protein family collagen-like repeats; mec-5 encodes a collagen unique in the number of Gly-X-Y repeats and in the composition of amino acids surrounding these repeats; MEC-5 is required for normal mechanosensory response to gentle touch and for the proper functioning of the touch receptor neurons; mec-5 interacts genetically with mec-4 and mec-10 which encode degenerins (ion channels) expressed in the touch neurons, mec-9, which encodes a protein containing EGF-like and Kunitz/protease inhibitor domains secreted by the touch neurons, and mec-12, which encodes an alpha-tubulin expressed in the touch neurons; these genetic interactions suggest that MEC-5 may play a role in anchoring the degenerin complex to the extracellular matrix; MEC-5 is produced and secreted by hypodermal cells. E03G2.4 E03G2.4 Protein containing two collagen triple helix repeats, which are found in some extracellular proteins, and a nematode cuticle collagen N-terminal domain, has a region of high similarity to a region of C. elegans LET-2, which is a type IV collagen cuticle collagen E03H12.1 E03H12.1 Member of the 7-transmembrane chemoreceptor family of G protein-coupled receptors (GPCR), has low similarity to C. elegans ODR-10, which is involved in odorant response 7TM chemoreceptor, str family E03H12.10 ssp-9;E03H12.10 Protein containing a major sperm protein (MSP) domain, which are involved in sperm motility, has strong similarity to uncharacterized C. elegans SSP-11 E03H12.2 E03H12.2 Protein with similarity to members of the C-type lectin family E03H12.3 E03H12.3 Protein of unknown function, has high similarity to uncharacterized C. elegans E03H12.2 E03H12.4 E03H12.4 Putative ortholog of C. elegans E03H12.3 gene product E03H12.5 E03H12.5 Protein with weak similarity to C. elegans Y113G7B.12 gene product E03H12.6 E03H12.6 Protein containing a DUF216 domain of unknown function, has moderate similarity to uncharacterized C. elegans C08F11.9 7TM chemoreceptor, srz family E03H12.7 E03H12.7 Protein of unknown function, has strong similarity to C. elegans T08H10.3 E03H12.9 E03H12.9 Protein of unknown function, has moderate similarity to C. elegans E03H12.2 E03H4.1 E03H4.1 Member of the transposase family, which are required for excising and inserting mobile genetic elements, has very strong similarity to uncharacterized C. elegans C10H11.2 transposase E03H4.10 E03H4.10 Member of the C-type lectin family, has similarity to human C-type mannose receptor MRC1, has similarity to D. melanogaster TOLLOID and TOLKIN proteins C-type lectin domain E03H4.11 E03H4.11 Member of the galactosyltransferase family, has a region of low similarity to UDP-galactose:beta-N-acetylglucosamine beta-1,3-galactosyltransferase (human B3GALT1), which requires beta-linked GlcNAc acceptors and is decreased in some colon adenocarcinomas E03H4.12 E03H4.12 Protein of unknown function, has moderate similarity to a region of glucuronyl transferase-I (GlcAT-I) (C. elegans SQV-8), which is involved in proteoglycan biosynthesis and is important for vulval invagination E03H4.13 nhr-89;E03H4.13 Member of the zinc finger protein family with similarity to nuclear hormone receptors, may be involved in epidermal fate specification Zinc finger, C4 type (two domains) E03H4.2 E03H4.2 Member of the domain of unknown function DUF13 family, has high similarity to uncharacterized C. elegans ZK1025.3 E03H4.3 E03H4.3 Member of the galactosyltransferase family, which transfer galactose to GlcNAc termini of growing oligosaccharide chains, has high similarity to uncharacterized C. elegans F56H6.1 E03H4.4 E03H4.4 Member of an uncharacterized protein family E03H4.5 E03H4.5 Protein of unknown function, has strong similarity to uncharacterized C. elegans T15D6.12 E03H4.6 nhr-B;E03H4.6 Protein containing nuclear hormone receptor C4-type and ligand-binding zinc finger domains, has a region of low similarity to a region of the glucocorticoid receptor (mouse Nr3c1), which is a transcription factor that functions in inflammation Zinc finger, C4 type (two domains) E03H4.7 E03H4.7 Protein containing a DUF33 domain of unknown function, has high similarity to uncharacterized C. elegans F14B6.5 E03H4.8 E03H4.8 Protein of unknown function, has high similarity to a region of coatomer protein (COP) complex subunit beta 2 (COP beta prime, mouse Copb2), which is part of a Golgi coatomer complex that comprises the coat of non-clathrin coated vesicles beta' coatomer protein like E04A4.1 E04A4.1 Protein containing an F-box domain, which serve as a link between a target protein and a ubiquitin-conjugating enzyme, has moderate similarity to uncharacterized C. elegans Y17G9B.7 This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins; its encoded protein also contains a Pfam-B45 motif of presently unknown function. E04A4.2 E04A4.2 Protein of unknown function, has moderate similarity to C. elegans M116.4 E04A4.3 E04A4.3 Protein of unknown function, has moderate similarity to uncharacterized C. elegans F25G6.1 E04A4.4 E04A4.4 Member of the metallo-beta-lactamase family, has low similarity to uncharacterized human ELAC2 hoe-1 is orthologous to human ELAC2 (OMIM:605367, associated with susceptibility to prostate cancer); hoe-1 is required for normally rapid growth and normally short body length in mass RNAi assays. E04A4.5 E04A4.5 Protein with high similarity to mitochondrial inner membrane translocase subunit 17b (human TIMM17B), which is involved in mitochondrial translocation, member of the mitochondrial import inner membrane translocase subunit Tim17 family E04A4.6 E04A4.6 Protein of unknown function E04A4.7 E04A4.7 Protein with high similarity to somatic cytochrome c (mouse Cycs), which is involved in mitochondrial respiration, contains a cytochrome c family heme-binding site domain cytochrome C; This gene encodes a protein predicted by Eisenberg and coworkers, with 52% accuracy, to be mitochondrial. E04A4.8 E04A4.8 Protein with high similarity to ribosomal protein L20 (S. cerevisiae Rpl20ap), which is a structural ribosomal protein, member of the ribosomal L18ae family, which form part of the large ribosomal subunit ribosomal protein; rpl-20 encodes a large ribosomal subunit L18a protein. E04D5.1 E04D5.1 Putative ortholog of S. cerevisiae Ygr054p, a protein of unknown function E04D5.2 E04D5.2 Protein of unknown function, has low similarity to uncharacterized C. elegans C54D10.5 E04D5.3 E04D5.3 Protein with strong similarity to C. elegans cut-1 (Cuticulin component) cuticlin like protein E04D5.4 E04D5.4 Protein of unknown function, has high similarity to uncharacterized C. elegans ZK673.1 E04F6.1 E04F6.1 Protein of unknown function, has strong similarity to uncharacterized C. elegans E04F6.13 7TM chemoreceptor, srd family E04F6.10 E04F6.10 Protein of unknown function E04F6.11 clc-3;clh-3;E04F6.11 Chloride channel protein, putative ortholog of H. sapiens CLCN1 gene product (chloride channel 1) Chloride channel protein; The clh-3 gene encodes a chloride channel homologous to the mammalian channel ClC-2. E04F6.12 E04F6.12 Protein of unknown function E04F6.13 E04F6.13 Protein with similarity to the C. elegans srd family of 7TM receptors 7TM chemoreceptor, srd family E04F6.14 E04F6.14 Protein with similarity to the C. elegans srd family of 7TM receptors 7TM chemoreceptor, srd family E04F6.15 E04F6.15 Putative ortholog of C. elegans DC2.5 gene product E04F6.2 E04F6.2 Protein of unknown function E04F6.3 E04F6.3 Protein containing a MaoC-like dehydratase domain, has high similarity to a region of type IV 17 beta-hydroxysteroid dehydrogenase (mouse Hsd17b4), which is a peroxisomal multifunctional enzyme with dehydrogenase and dehydratase activities Hydratase-dehydrogenase-epimerase; E04F6.3 encodes a protein that is orthologous (with 52% identity over 93% of its length) to residues 334-609 of human 17-BETA-HYDROXYSTEROID DEHYDROGENASE IV (HSD17B4; OMIM:601860, mutated in D-bifunctional protein deficiency), a protein of 736 residues whose N- and C-terminal domains are orthologous to DHS-28; E04F6.3 contains a MaoC-like domain, found in diverse enzymes (HSD17B4, peroxisomal hydratase-dehydrogenase-epimerase, and the fatty acid synthase beta subunit); E04F6.3 has no obvious function in mass RNAi assays. E04F6.4 E04F6.4 Protein containing two phospholipase D active site motifs V. virus protein K4 E04F6.5 E04F6.5 Protein with high similarity to rat Acadvl, which is a very-long-chain acyl-coenzyme A dehydrogenase, contains an acyl-CoA dehydrogenase N-terminal domain, an acyl-CoA dehydrogenase middle domain, and an acyl-CoA dehydrogenase C-terminal domain Isovaleryl-CoA dehydrogenase; E04F6.5 is orthologous to the human gene ACYL-CoA DEHYDROGENASE, VERY LONG-CHAIN (OMIM:201475), which when mutated leads to VLCAD deficiency, an inborn error of mitochondrial beta-oxidation. E04F6.6 E04F6.6 Protein of unknown function, has strong similarity to C. elegans C50D2.1 E04F6.7 E04F6.7 Member of the short-chain dehydrogenase-reductase family, which are NAD- or NADP-dependent oxidoreductases, has moderate similarity to WW domain-containing oxidoreductase (mouse Wwox), which is an apoptosis activator induced by hyaluronidase Ribitol dehydrogenase; dhs-7 encodes a short-chain dehydrogenase predicted to be mitochondrial. E04F6.8 E04F6.8 Protein of unknown function, has high similarity to uncharacterized C. elegans E04F6.9 E04F6.9 E04F6.9 Protein of unknown function, has moderate similarity to C. elegans E04F6.8 EEED8.1 EEED8.1;2F713 Protein containing two tudor domains, which are found in proteins involved in RNA localization EEED8.10 EEED8.10 Protein containing an RNA recognition motif (RRM, RBD, or RNP), has a region of weak similarity to F box leucine rich repeat 3 (human FBXL2), which is a putative subunit of the SCF ubiquitin ligase involved in protein degradation Probable RNA binding protein.; This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins. EEED8.11 EEED8.11 Protein of unknown function, has moderate similarity to uncharacterized C. elegans C04H5.2 EEED8.12 EEED8.12 Protein containing an RNA recognition motif (RRM, RBD, or RNP), has a region of moderate similarity to a region of poly(A)-binding protein (nuclear 1, human PABPN1), which stimulates long poly(A) tail synthesis and may play a role in nuclear mRNA export Probable RNA binding protein EEED8.13 EEED8.13 Protein of unknown function EEED8.14 EEED8.14 Putative coiled-coil protein EEED8.15 EEED8.15 Protein of unknown function EEED8.16 EEED8.16 Protein with weak similarity to C. elegans Y4C6B.A gene product EEED8.2 EEED8.2 Protein of unknown function EEED8.3 EEED8.3 Protein of unknown function EEED8.4 EEED8.4 Protein containing an RNA recognition motif (RRM, RBD, or RNP), has a region of moderate similarity to a region of poly(A)-binding protein (nuclear 1, human PABPN1), which stimulates long poly(A) tail synthesis and may play a role in nuclear mRNA export Probable RNA binding protein EEED8.5 mog-5;EEED8.5;CeHRH1 Member of the RNA helicase, DEAH-box protein family; an SR-like protein RNA helicase; The mog-5 gene encodes a DEAH helicase orthologous to the Drosophila CG8241, the human HRH1, and the S. cerevisiae PRP22 proteins. EEED8.6 EEED8.6 Protein with strong similarity to C. elegans F56H1.5 gene product EEED8.7 rsp-4;srp-2;CeSC35;EEED8.7 SR protein involved in mRNA splicing splicing factor SC35 EEED8.8 EEED8.8 Member of the bacterial mutT protein family The ndx-6 gene encodes a NUDIX hydrolase. EEED8.9 EEED8.9 Protein containing two protein kinase domains, has a region of low similarity to a region of S. cerevisiae Rad53p, which is a serine-threonine-tyrosine protein kinase with a checkpoint function in the S and G2 phases of the cell cycle EGAP1.1 EGAP1.1 Protein of unknown function EGAP2.1 EGAP2.1 Protein of unknown function EGAP2.2 EGAP2.2 Protein of unknown function EGAP2.3 EGAP2.3 Member of the histidine acid phosphatase family, which hydrolyze phosphate esters at low pH, has low similarity to human ACPP, which is a prostatic acid phosphatase that dephosphorylates the oncoprotein human ERBB2 and negatively regulates cell growth pho-1 encodes the major C. elegans intestinal acid phosphatase; as loss of PHO-1 function via RNA-mediated interference (RNAi) does not result in any abnormalities, PHO-1 may function redundantly with other acid phosphatases; PHO-1 intestinal expression appears to be positively regulated by CKI-1, a cyclin-dependent kinase inhibitor, and negatively regulated by POP-1, a TCF/LEF transcription factor; PHO-1 is expressed along the intestinal brush border in all gut cells except the most anterior int-1 and int-2 cells, beginning at the three-fold stage of embryogenesis. EGAP4.1 EGAP4.1 Protein of unknown function, has weak similarity to C. elegans F59D6.1 transposase EGAP5.1 EGAP5.1 Protein with strong similarity to C. elegans EGSP.1 gene product EGAP7.1 EGAP7.1 Protein containing two collagen triple helix repeats, which are found in some extracellular proteins, and a nematode cuticle collagen N-terminal domain, has a region of high similarity to a region of collagen type IX alpha 3 (human COL9A3) cuticular collagen EGAP798.A EGAP798.1;EGAP798.A Putative ortholog of C. elegans W09B7.D gene product EGAP9.2 EGAP9.2 Member of the glycosyl transferase family 11, which hydrolyze the glycosidic bond between two or more carbohydrates, has high similarity to uncharacterized C. elegans EGAP9.3 EGAP9.3 EGAP9.3 Member of the glycosyl transferase family 11, which hydrolyze the glycosidic bond between two or more carbohydrates, has high similarity to uncharacterized C. elegans EGAP9.2 F01D4.1 F01D4.1 Protein containing a UDP-glucoronosyl and UDP-glucosyl transferase domain, has low similarity to olfactory UDP-glucuronosyltransferase (human UGT2A1), which catalyzes the glucuronidation of substrates such as odorants, steroids, drugs, and carcinogens UDP-glucoronosyltransferase F01D4.2 F01D4.2 Protein containing two UDP-glucoronosyl and UDP-glucosyl transferase domains, has low similarity to UDP-glucuronosyltransferase 8 (UDP-galactose ceramide galactosyltransferase, rat Ugt8), which acts in the biosynthesis of galactosylceramide UDP-glucoronosyltransferase F01D4.3 F01D4.3 Protein containing a protein kinase domain and a Src homology 2 (SH2) domain, has moderate similarity to fer (fps/fes related) tyrosine kinase (mouse Fert2), which may mediate cell-cell signaling and cell size-dependent cytoskeletal reorganization tyrosine-protein kinase (FES/FPS subfamily) F01D4.4 F01D4.4 Member of the carboxypeptidase A metalloprotease (M14) family of zinc carboxypeptidases, has moderate similarity to carboxypeptidase E (human CPE), which is a metalloprotease involved in the processing of peptide hormones and neurotransmitters zinc carboxypeptidase; Uncloned locus that affects egg laying. F01D4.5 F01D4.5 Protein of unknown function F01D4.6 mec-3;F01D4.6 LIM homeodomain transcription factor required for expression of mec-4 and mec-7 and required for touch receptor cell differentiation, has similarity to human LIM-1 and D. melanogaster LIM3 LIM homeodomain transcription factors LIM domain containing proteins (2 domains), homeobox protein (lim subfamily) F01D4.7 F01D4.7 G protein-coupled receptor; member of a subfamily with SRB proteins, which are expressed in chemosensory neurons; no homolog found in human or D. melanogaster 7TM receptor, srb family F01D4.8 F01D4.8 Member of the pyridoxal phosphate dependent enzyme beta family, has high similarity to uncharacterized C. elegans F13B12.4 cysteine synthase like F01D5.1 F01D5.1 Protein containing a DUF18 domain of unknown function, has high similarity to uncharacterized C. elegans Y39G8B.7 F01D5.10 F01D5.10 Protein of unknown function, has high similarity to uncharacterized C. elegans F25E5.2 F01D5.11 F01D5.11 Protein containing a DUF38 domain of unknown function F01D5.2 F01D5.2 Protein of unknown function, has high similarity to uncharacterized C. elegans F01D5.3 F01D5.3 F01D5.3 Protein of unknown function, has high similarity to uncharacterized C. elegans F01D5.2 F01D5.5 F01D5.5 Protein of unknown function, has strong similarity to C. elegans F01D5.1 F01D5.6 F01D5.6 Protein of unknown function, has weak similarity to C. elegans Y12A6A.1 F01D5.7 F01D5.7 Protein of unknown function, has high similarity to uncharacterized C. elegans F01D5.8 F01D5.8 F01D5.8 Member of the phospholipase and carboxylesterase family, which have broad substrate specificity, has moderate similarity to uncharacterized human LOC51104 F01D5.9 F01D5.9 Member of the cytochrome P450 family, has moderate similarity to cytochrome P450 subfamily 4F polypeptide 2 (human CYP4F2), which is an arachidonic acid- and leukotriene B4 omega-hydroxylase that regulates salt and water homeostasis in liver and kidney Cytochrome P450 F01E11.1 F01E11.1 Protein containing a UDP-glucoronosyl and UDP-glucosyl transferase domain, has low similarity to UDP-glucuronosyltransferase 8 (UDP-galactose ceramide galactosyltransferase, mouse Ugt8), which acts in the biosynthesis of galactosylceramide UDP-glucuronosyltransferase F01E11.2 F01E11.2 Protein of unknown function F01E11.3 F01E11.3 Protein of unknown function F01E11.4 F01E11.4 Member of the tetraspanin family, which contain an N-terminal transmembrane domain that is a signal sequence and membrane anchor transpanin F01E11.5 F01E11.5 Member of the rhodopsin family of G protein-coupled receptors (GPCR), has low similarity to 5-hydroxytryptamine (serotonin) 1A receptor (rat Htr1a), which acts via Gi-Go to inhibit adenylyl cyclase and plays a role in anxiety, pain, sleep and feeding G-protein coupled receptor F01F1.1 F01F1.1 Protein of unknown function, has a region of low similarity to a region of minichromosome maintenance deficient 3 associated protein (mouse Mcm3ap), which is a DNA primase that binds mouse Mcmd and may regulate development of antigen-driven B-cells F01F1.10 F01F1.10 Protein with similarity to an Arthrobacter protophormiae glucosaminidase over the amino terminus F01F1.10 encodes two isoforms of an endo-beta-N-acetylglucosaminidase (ENGase, or Endo-M); recombinant F01F1.10 has ENGase activity when expressed in E. coli, with specificity mainly for high-mannose type oligosaccharides, and optimal activity on Man8GlcNAc2; F01F1.10 has no obvious phenotype in mass RNAi screens; F01F1.10 is predicted to catabolize free oligosaccharides in the cytosol. F01F1.11 F01F1.11 Protein with strong similarity to C. elegans Y47H9C.8 gene product F01F1.12 F01F1.12 Member of the fructose-bisphosphate aldolase class-I protein family Fructose-biphosphate aldolase; The F01F1.12 gene encodes a homolog of the human gene ADHUB, which when mutated leads to fructosemia (OMIM:229600). F01F1.13 F01F1.13 Protein containing two type 1 thrombospondin domains, has a region of low similarity to a region of semaphorin 5B (semaphorin G, mouse Sema5b), which is involved in embryogenesis F01F1.14 F01F1.14 Protein of unknown function F01F1.15 F01F1.15 Protein of unknown function F01F1.2 F01F1.2 Protein of unknown function F01F1.3 F01F1.3 Protein of unknown function F01F1.4 F01F1.4 Protein containing a FYVE zinc finger domain, which bind phosphatidylinositol 3-phosphate F01F1.5 F01F1.5 Member of the prolyl oligopeptidase family and the dienelactone hydrolase family, has a region of low similarity to a region of N-acylaminoacyl-peptide hydrolase (rat Apeh), which catalyzes the release an N-acetylamino acid from an N-acetylated peptide F01F1.6 F01F1.6 Member of the aldehyde dehydrogenase family, which use NADP as a cofactor, has low similarity to mouse Aldh1a3, which is an aldehyde dehydrogenase that catalyzes the conversion of all-trans-retinaldehyde to retinoic acid Aldehyde dehydrogenase F01F1.7 F01F1.7 Member of the DEAD or DEAH box ATP-dependent RNA helicase family and contains two helicase conserved C-terminal domains, has low similarity to S. cerevisiae Prp28p, which is a pre-mRNA splicing factor required for the first covalent step of splicing RNA helicase F01F1.8 cct-6;F01F1.8 Member of the chaperonin complex family eukaryotic cytosolic chaperonin; affects viability and fertility, and is expressed in various muscle and neuronal cells: near the pharynx, near the anal sphincter, in the ventral nerve cord and the nerve ring; occasionally the expression is visible in hypodermal cells and in some vulval cells. F01F1.9 F01F1.9 Member of the peptidase Lap4p-like protein family F01G10.1 F01G10.1 Protein with high similarity to transketolase (mouse Tkt), which may transfer a two-carbon ketol from a ketose to an aldose, contains a transketolase thiamine diphosphate binding domain, C-terminal domain and pyridine binding domain transketolase; The F01G10.1 gene encodes an ortholog of the human gene TRANSKETOLASE (TKT; OMIM:606781), which when mutated leads to Wernicke-Korsakoff syndrome (OMIM:277730). F01G10.10 F01G10.10 Protein containing lipopolysaccharide-binding protein, bactericidal permeability-increasing protein, or cholesteryl ester transfer protein N-terminal and C-terminal domains, has weak similarity to uncharacterized C. elegans C55C3.1 lipopolysaccharide-binding protein like F01G10.2 F01G10.2 Protein containing 3-hydroxyacyl-CoA dehydrogenase NAD binding and C-terminal domains, which are involved in fatty acid metabolism, has low similarity to a region of rat Ehhadh, which is a hydratase and 3-hydroxyacyl coenzyme A dehydrogenase enoyl-CoA hydratase F01G10.3 F01G10.3 Protein containing a 3-hydroxyacyl-CoA dehydrogenase NAD binding domain and a 3-hydroxyacyl-CoA dehydrogenase C-terminal domain, has low similarity to a region of rat Ehhadh, which is a bifunctional hydratase and 3-hydroxyacyl coenzyme A dehydrogenase enoyl-CoA hydratase F01G10.4 F01G10.4 Protein with weak similarity to H. sapiens CENPE (centromere protein E (312kD)) F01G10.5 F01G10.5 Putative coiled-coil protein, has similarity to human MYH9, a myosin heavy polypeptide F01G10.6 F01G10.6 Protein of unknown function, predicted to contain a glycosylphosphatidylinositol (GPI) lipid anchor F01G10.7 F01G10.7 Member of the alpha or beta hydrolase fold family, has moderate similarity to lysosomal acid lipase A (human LIPA), which deacylates cholesteryl and triacylglyceryl ester lipids and is associated with Wolman disease and cholesteryl ester storage disease triacylglycerol lipase F01G10.8 daf-14;F01G10.8 A divergent member of the Smad family of small signaling molecules involved in dauer larva regulation and several additional processes Mouse MSMAD protein like; daf-14 encodes a Smad-related protein that is unusual in that while its C-terminus is well-conserved with Smad proteins, it lacks the N-terminal DNA binding domain found in all other known Smads; DAF-14 is predicted to function as a transducer of the DAF-7/TGF-beta-mediated signal that promotes reproductive growth and negatively regulates dauer formation; as reduction of daf-14 function enhances the dauer constitutive phenotype of daf-8 mutants, and overexpression of daf-14 can rescue daf-8 mutant animals, it is likely that the DAF-14 and DAF-8 Smad proteins function in parallel to control dauer formation; further genetic analyses suggest that DAF-14 and DAF-8 function to antagonize the activities of the DAF-3 Smad and DAF-5 Sno/Ski oncoprotein, which are required for dauer formation; a DAF-14::GFP reporter is expressed in a dynamic pattern in tissues, such as the hypodermis, intestine, and pharynx, that are remodeled during dauer development. F01G10.9 F01G10.9 Protein of unknown function F01G12.1 F01G12.1 Protein of unknown function, has weak similarity to C. elegans F27C1.2 F01G12.2 F01G12.2 Protein of unknown function F01G12.3 F01G12.3 Protein of unknown function F01G12.5 let-2;clb-1;sup-20;let-8;F01G12.5 Type IV collagen of basement membrane, putative ortholog of mammalian alpha2 collagen alpha-2 type IV collagen; let-2 encodes an alpha-2 type IV collagen, probably most closely equivalent to the human gene COL4A2 (OMIM:120090) on the basis of biological function; LET-2 is required for embryonic development and is a component of the basement membrane between muscle and hypodermis; LET-2 interacts with UNC-105, a mechanosensory ion channel of the degenerin ion channel superfamily that is expressed in muscle and required for normal growth, muscle contraction, and muscle organization. F01G12.6 F01G12.6 Protein with strong similarity to human Hs.179747 protein, a EVI5 homolog, a cell cycle regulator F01G4.1 psa-4;F01G4.1 Putative component of a SWI/SNF chromatin remodeling complex, active in the control of mitosis SNF2alpha like; The psa-4 (phasmid socket absent) gene encodes an ortholog of SWI2/SNF2, a component of the SWI/SNF complex that is conserved from yeast to mammals and that is involved in chromatin remodeling; psa-4 is probably required during mitosis of the T cells for asymmetric cell division. F01G4.2 F01G4.2;sad-1 Protein with high similarity to human HADH2, which is a type II hydroxyacyl-Coenzyme A dehydrogenase that binds beta-amyloid and may be associated with Alzheimer's disease, member of the short-chain dehydrogenase-reductase family short-chain alcohol dehydrogenase; ard-1 encodes a homolog of mammalian 3-hydroxyacyl-CoA dehydrogenase (HADH II)/amyloid-beta binding alcohol dehydrogenase (ABAD) that is predicted to be mitochondrial. F01G4.3 F01G4.3 Member of the DEAD or DEAH box ATP-dependent RNA helicase family and contains a helicase conserved C-terminal domain, has moderate similarity to human SKIV2L, which is an ATP-dependent RNA helicase localized in the small subunit of the ribosome antiviral protein SKI2 like F01G4.4 F01G4.4 Protein with weak similarity to C. elegans Y25C1A.L gene product F01G4.5 F01G4.5 Protein of unknown function, has low similarity to a region of phosphatidylinositol glycan class Q (human PIGQ), which is a part of the GPI-N-acetylglucosaminyl transferase enzyme complex that transfers N-acetylglucosamine from UDP to phosphatidylinositol F01G4.6 F01G4.6 Member of the mitochondrial carrier protein family of membrane transporters, has moderate similarity to mitochondrial import receptor 1 (S. cerevisiae Mir1p), which is a mitochondrial carrier phosphate transporter phosphate carrier protein precursor F02A9.1 F02A9.1 Protein of unknown function F02A9.2 F02A9.2 Protein of unknown function, has high similarity to uncharacterized C. elegans F02A9.3 O. volvulus 20Kd antigenic peptide; far-1 encodes a fatty acid/retinol binding protein; expressed throughout development with highest expression levels in L3 stage larvae and in adult males. F02A9.3 F02A9.3 Protein of unknown function, has high similarity to uncharacterized C. elegans F02A9.2 far-2 encodes a protein similar to a class of secreted fatty acid and retinol-binding proteins expressed in parasitic nematodes and secreted in the surrounding tissues of the host; expressed in body wall muscle and vulval cells of adult hermaphrodites, and transcript levels progressively increase during development. F02A9.5 F02A9.4;F02A9.5 Protein containing a carboxyl transferase domain, has low similarity to propionyl Coenzyme A carboxylase (propanoyl-CoA:carbon-dioxide ligase) beta polypeptide (human PCCB), which degrades branched-chain amino acids and has a role in propionic acidemia F02A9.6 glp-1;emb-33;F02A9.6 Notch-related receptor involved in establishment of early embryonic polarity and germ line proliferation GLP-1 protein; glp-1 encodes an N-glycosylated transmembrane protein that, along with LIN-12, comprises one of two C. elegans members of the LIN-12/Notch family of receptors; from the N- to the C-terminus, GLP-1 is characterized by ten extracellular EGF-like repeats, three LIN-12/Notch repeats, a CC-linker, a transmembrane domain, a RAM domain, six intracellular ankyrin repeats, and a PEST sequence; in C. elegans, GLP-1 activity is required for cell fate specification in germline and somatic tissues; in the germline, GLP-1, acting as a receptor for the DSL family ligand LAG-2, is essential for mitotic proliferation of germ cells and maintenance of germline stem cells; in somatic tissues, maternally provided GLP-1, acting as a receptor for the DSL family ligand APX-1, is required for inductive interactions that specify the fates of certain embryonic blastomeres; GLP-1 is also required for some later embryonic cell fate decisions, and in these decisions its activity is functionally redundant with that of LIN-12; GLP-1 expression is regulated temporally and spatially via translational control, as GLP-1 mRNA, present ubiquitously in the germline and embryo, yields detectable protein solely in lateral, interior, and endomembranes of distal, mitotic germ cells, and then predominantly in the AB blastomere and its descendants in the early embryo; proper spatial translation of glp-1 mRNA in the embryo is dependent upon genes such as the par genes, that are required for normal anterior-posterior asymmetry in the early embryo; signaling through GLP-1 controls the activity of the downstream Notch pathway components LAG-3 and LAG-1, the latter being predicted to function as part of a transcriptional feedback mechanism that positively regulates GLP-1 expression; signaling through the DNA-binding protein LAG-1 is believed to involve a direct interaction between LAG-1 and the GLP-1 RAM and ankyrin domains. F02C12.1 F02C12.1 Protein of unknown function F02C12.2 F02C12.2 Member of the short-chain dehydrogenase-reductase family, which are NAD- or NADP-dependent oxidoreductases, has low similarity to human HSA250303, which is a peroxisomal trans 2-enoyl CoA reductase glucose 1-dehydrogenase; This gene encodes a protein predicted by Eisenberg and coworkers, with 68% accuracy, to be mitochondrial. F02C12.3 F02C12.3 Protein of unknown function F02C12.4 F02C12.4 Protein containing one DUF41 domain of unknown function F02C12.5 F02C12.5 Member of the cytochrome P450 family, has low similarity to cytochrome P450 subfamily 3a polypeptide 9 (rat Cyp3a9), which is a sexually dimorphically expressed enzyme that demethylates erythromycin and benzphetamine cytochrome P450 F02C9.1 F02C9.1 Protein of unknown function F02C9.2 F02C9.2 Protein of unknown function, has high similarity to uncharacterized C. elegans F56A4.6 F02C9.3 F02C9.3 Member of the P-type ATPase, Drs2p subfamily protein family ATPase F02C9.4 F02C9.4 Protein of unknown function, has weak similarity to C. elegans F45C12.1 F02D10.1 F02D10.1 Protein with high similarity to C. elegans DPY-16, which is a collagen, contains a nematode cuticle collagen N-terminal domain cuticle collagen F02D10.2 F02D10.2 Protein of unknown function F02D10.3 F02D10.3 Protein of unknown function F02D10.4 F02D10.4 Protein of unknown function F02D10.5 F02D10.5 Protein with very strong similarity to C. elegans FLR-1, which is a membrane protein that confers wild-type sensitivity to fluoride, member of the amiloride-sensitive sodium channel family, which are involved in sodium reabsorption sodium channel like F02D10.6 F02D10.6 Protein of unknown function, has moderate similarity to uncharacterized C. elegans C49F5.3 F02D10.7 F02D10.7 Protein containing a SET domain, which are involved in protein-protein interactions, has weak similarity to a region of C. elegans MES-4, which is a putative G protein-coupled receptor expressed in chemosensory neurons trithorax like protein F02D8.1 F02D8.1 Protein of unknown function F02D8.2 F02D8.2 Protein of unknown function containing a Ground-like domain, has weak similarity to C. elegans grd-9 F02D8.3 F02D8.3 Protein of unknown function, has low similarity to uncharacterized CGI-60 (human LOC51626) F02D8.4 F02D8.4 Member of the carboxypeptidase A metalloprotease (M14) family of zinc carboxypeptidases, has moderate similarity to a region of carboxypeptidase B1 (rat Cpb1), which is a primary manganese-binding protein in the pancreas carboxypeptidase F02E11.1 F02E11.1 Member of the ABC transporter family, has low similarity to ATP-binding cassette subfamily G member 1 (mouse Abcg1), which is an ABC transporter involved in cellular sterol homeostasis ABC transpoter F02E11.2 F02E11.2 Protein of unknown function F02E11.3 F02E11.3 Protein of unknown function F02E11.4 F02E11.4 Protein of unknown function, has high similarity to uncharacterized C. elegans Y110A2AL.1 F02E11.5 F02E11.5 Member of the SCP-like extracellular protein family, has low similarity to a region of specific granule protein 28kDa (human SGP28), which is a widely expressed and localizes to specific granules in neutrophils F02E8.1 F02E8.1 Protein of unknown function, has high similarity to uncharacterized C. elegans F35G12.10 ATP synthase B chain; asb-2 encodes a ATP synthase B homolog. F02E8.2 F02E8.2 Member of the rhodopsin family of G protein-coupled receptors (GPCR), has low similarity to G protein-coupled receptor FM-3 (rat Gpr66), which is predicted to bind neuromedin U (rat Nmu) G-protein coupled receptor F02E8.3 aps-2;F02E8.3 Member of the clathrin-associated protein family with 92% identity to mammalian Ap-17 Clathrin coat assembly protein; The aps-2 gene encodes an adaptin: specifically, it encodes an ortholog of the sigma2 subunit of adaptor protein complex 2 (AP-2), which mediates endocytosis from the plasma membrane; APS-2 appears to be required for embryonic and larval development and for normal body morphology, but is not required for endocytosis of yolk protein in developing oocytes; APS-2 is expressed in nearly all cells during embryogenesis, but during larval and adult stages, expression is confined to neurons and some hypodermal cells, including vulval hypodermal cells during the fourth larval stage. F02E8.4 F02E8.4 Protein of unknown function, has low similarity to uncharacterized C. elegans R09A8.2 F02E8.5 F02E8.5 Protein containing seven WD domains (WD-40 repeat), which may mediate protein-protein interactions, has weak similarity to S. cerevisiae Mdv1p, which is a protein involved in mitochondrial division F02E8.6 npc-1;F02E8.6 Functions in cholesterol metabolism and possibly general vesicular trafficking and has strong similarity to human NPC1, which is associated with the lysosomal storage disease Niemann-Pick type C ncr-1 encodes a large transmembrane glycoprotein with a patched-like domain that is orthologous to human NPC1 (OMIM:257220, mutated in Niemann-Pick type C disease); NCR-1 and NPC1 are eukaryotic members of the resistance-nodulation-division (RND) family of membrane permeases, and have a putative sterol-sensing domain; by homology, NCR-1 is predicted to function in intracellular cholesterol and glycolipid trafficking; in C. elegans, NCR-1 is required for growth and survival in the absence of cholesterol, newly hatched ncr-1 mutant larvae grow poorly on cholesterol-free medium and die at the L1 or L2 stage; NCR-1 is also involved in negative regulation of dauer formation, being required redundantly with NCR-2, a second C. elegans NPC1-like protein, for preventing constitutive dauer formation; dauer formation in ncr-1; ncr-2 double mutants is suppressed by mutations in daf-12, which encodes a steroid hormone receptor, and by overexpression of daf-9, which encodes a cytochrome P450, suggesting that NCR-1 and NCR-2 may function to transport a sterol precursor that is metabolized by DAF-9 to then serve as the DAF-12 ligand. F02E9.1 F02E9.1 Protein of unknown function F02E9.10 F02E9.10 Protein with weak similarity to C. elegans R06A4.9 gene product F02E9.2 lin-28;F02E9.2 Protein required for developmental timing of the ectoderm and cuticle; has weak similarity to H. sapiens YB1 gene product cold shock domain; lin-28 encodes a cytoplasmic protein with a cold shock domain and retroviral-type (CCHC) zinc finger motifs; LIN-28 is required for events specific to the second larval stage, which in lin-28 mutants are skipped, and is itself subject both to negative regulation (by binding of the lin-4 stRNA to an element in the lin-28 3' UTR) and to positive regulation (by LIN-14, which negatively regulates lin-4-independent inhibition also acting on the lin-28 3' UTR). F02E9.3 F02E9.3 Protein of unknown function, has moderate similarity to uncharacterized C. elegans C47E12.11 ubiquitin carboxyl-terminal hydrolase F02E9.4 F02E9.4 Protein containing a paired amphipathic helix repeat, which may mediate protein-protein interactions, has weak similarity to transcriptional regulator SIN3 yeast homolog B (mouse Sin3b), which functions as a transcriptional co-repressor pqn-28 encodes an ortholog of the SIN3 family of histone deacetylase subunits, which also has a glutamine/asparagine-rich domain, possibly involved in epigenetic regulation; pqn-28 has no obvious phenotype in mass RNAi screens; on the basis of its homology, PQN-28, when activated by promoter-specific transcription factors, is expected to work in conjunction with other histone deacetylase components to induce chromatin silencing; PQN-28 may also silence genes by colocating to them with the O-GlcNAc transferase homolog OGT-1. F02E9.5 F02E9.5 Protein of unknown function F02E9.6 F02E9.6 Putative ortholog of S. cerevisiae Yol057p, a protein of unknown function F02E9.7 F02E9.7 Member of the purple acid phosphatase family, which catalyze hydrolysis of phosphate esters, has moderate similarity to human ACP5, which is a binuclear redox-sensitive iron-containing lysosomal phosphatase secreted into serum during bone resorption acid phosphatase F02E9.9 F02E9.9 Protein with moderate similarity to D. melanogaster CG7415 (CG7415 gene product) WD domain, G-beta repeat F02G3.1 F02G3.1 Protein containing ten immunoglobulin (Ig) domains, which may be involved in protein interactions, and four fibronectin type III domains, which are involved in cell surface binding, has weak similarity to neural cell adhesion molecule (rat Ncam1) neural cell adhesion molecule F02H6.1 F02H6.1 Protein with moderate similarity to C. elegans K01G12.3 gene product F02H6.2 F02H6.2 Putative ortholog of C. elegans K01G12.3 gene product F02H6.3 F02H6.3 Protein of unknown function F02H6.4 F02H6.4 Protein with strong similarity to C. elegans W06D11.5 gene product F02H6.5 F02H6.5 Protein with similarity to S. pombe HMT2 sulfide oxidation/cadmium resistance protein F02H6.6 F02H6.6 Protein of unknown function, has high similarity to uncharacterized C. elegans F02H6.7 F02H6.7 F02H6.7 Protein of unknown function, has high similarity to uncharacterized C. elegans F02H6.6 F07A11.1 F07A11.1 Protein with weak similarity to C. elegans D1044.6 F07A11.2 F07A11.2 Protein with high similarity to glutamine-fructose-6-phosphate transaminase 1 (mouse Gfpt1), which catalyzes the first step in glucosamine formation, contains four sugar isomerase (SIS) domains and two glutamine amidotransferases class II domains glucosamine-fructose-6-phosphate aminotransferase F07A11.3 F07A11.3 Protein of unknown function F07A11.4 F07A11.4 Member of the ubiquitin carboxyl-terminal hydrolase family 2, contains MYND finger and UCH-1 domains, has a region of low similarity to ubiquitin specific protease 11 (human USP11), which is involved in protein deubiquination ubiquitin carboxyl-terminal hydrolase F07A11.5 F07A11.5 Member of the PfkB family of carbohydrate kinases, has low similarity to ribokinase (S. cerevisiae Rbk1p), which is involved in temperature response ribokinase F07A11.6 F07A11.6 Protein of unknown function, has weak similarity to a region of SMRT and HDAC1 associated repressor protein (human SHARP), which is a transcriptional repressor that regulates liganded and nonliganded nuclear receptors RNA recognition motif. (aka RRM, RBD, or RNP domain) F07A5.1 opu-14;inx-14;F07A5.1 Member of the integral membrane innexin family, which are involved in the formation of gap junctions, has weak similarity to C. elegans INX-3, which is an innexin that forms connexin-like intercellular channels UNC-7 like; inx-14 encodes a predicted member of the innexin family that affects embryonic viability and fertility. F07A5.2 F07A5.2 Protein of unknown function F07A5.3 F07A5.3 Member of the CD36 family of putative scavenger receptors, has weak similarity to scavenger receptor BI (mouse Srb1), which mediates the selective uptake of cholesterol from high and low density lipoproteins and activates endothelial nitric oxide membrane glycoprotein F07A5.4 F07A5.4 Protein of unknown function F07A5.5 F07A5.5 Protein containing a C2 domain, which may be involved in calcium-dependent phospholipid binding C2 domain F07A5.6 F07A5.6 Protein of unknown function F07A5.7 unc-15;F07A5.7 Paramyosin, major component of muscle filaments, structural equivalent of the rod region of myosin heavy chains paramyosin; The unc-15 gene encodes a paramyosin ortholog; UNC-15 protein physically interacts with MHC A, one isoform of myosin heavy chain (MHC) in striated muscle; UNC-15 accumulation is decreased in the absence of UNC-54 (myosin B), implying that degradation of UNC-15 is inhibited by its binding myosin B; conversely, myosin B (but not MYO-3/myosin A) fails to accumulate in unc-15 mutants. F07B10.1 cln-3.1;F07B10.1 Member of the CLN3 protein family, has moderate similarity to ceroid-lipofuscinosis neuronal 3 (human CLN3), which plays a role in lysosomal pH homeostasis and is associated with juvenile Batten disease Human CLN3 protein like; cln-3.1 is orthologous to the human gene CEROID-LIPOFUSCINOSIS, NEURONAL 3, JUVENILE (BATTEN, SPIELMEYER-VOGT DISEASE) (CLN3; OMIM:607042), which when mutated leads to disease. F07B10.2 F07B10.2 Member of the 7-transmembrane chemoreceptor family of G protein-coupled receptors (GPCR), has low similarity to C. elegans ODR-10, which is involved in odorant response 7TM receptor F07B10.3 F07B10.3 Member of the 7-transmembrane chemoreceptor family of G protein-coupled receptors (GPCR), has low similarity to C. elegans ODR-10, which is involved in odorant response 7TM receptor F07B7.10 F07B7.10 Protein with strong similarity to C. elegans B0035.7 gene product his-51 encodes an H2A histone. F07B7.11 F07B7.11 Putative ortholog of C. elegans F07B7.4 gene product his-54 encodes an H2B histone; by homology, HIS-54 is predicted to function as a nucleosome component required for packaging of DNA into chromatin. F07B7.3 F07B7.3 Protein with strong similarity to C. elegans B0035.7 gene product his-53 encodes an H2A histone. F07B7.4 F07B7.4 Putative ortholog of C. elegans F07B7.11 gene product his-52 encodes an H2B histone. F07B7.6 F07B7.6 Putative ortholog of C. elegans C03A7.1 gene product F07B7.8 F07B7.8 Putative ortholog of C. elegans K06C4.1 gene product F07B7.A F07B7.14;F07B7.A Putative ortholog of C. elegans W09B7.A gene product F07B7.B F07B7.13;F07B7.B Putative ortholog of C. elegans C01B7.7 gene product F07B7.C F07B7.12;F07B7.C Putative ortholog of C. elegans rpm-1 gene product F07B7.E F07B7.9;F07B7.E Protein with strong similarity to C. elegans B0035.9 gene product F07B7.H F07B7.7;F07B7.H Putative ortholog of C. elegans ZC411.1 gene product F07B7.L F07B7.5;F07B7.L Putative ortholog of C. elegans B0035.10 gene product F07B7.N F07B7.2;F07B7.N Putative ortholog of C. elegans W09B7.B gene product F07B7.O F07B7.1;F07B7.O Putative ortholog of C. elegans W09B7.C gene product F07C3.1 ptd-2;F07C3.1 Protein with weak similarity to C. elegans CHE-14, which is required for normal chemotaxis towards water-soluble chemicals as well as secretory processes in the hypodermis and the amphid support cells F07C3.10 F07C3.10 Protein containing nuclear hormone receptor ligand-binding and C4-type zinc finger domains, which bind DNA and may be involved in regulation of transcription, has a region of low similarity to peroxisome proliferator activated receptor delta (mouse Ppard) zinc finger protein F07C3.2 F07C3.2 Protein of unknown function F07C3.3 F07C3.3 Member of uncharacterized DUF229 family, has low similarity to uncharacterized C. elegans M03F8.5 F07C3.4 F07C3.4 Protein containing five regulator of chromosome condensation (RCC1) repeat domains, has a region of low similarity to a region of HECT (homologous to E6-AP (UBE3A) carboxy terminus) domain and RCC1 (CHC1)-like domain (RLD) 1 (human HERC1) guanine-nucleotide releasing factor; The F07C3.4 gene encodes a guanine-nucleotide releasing factor homolog that is homologous to human RP3. F07C3.5 F07C3.5 Protein of unknown function F07C3.7 F07C3.7 Member of the amino acid permease family, putative ortholog of human cationic amino acid transporters SLC7A6, SLC7A7, and y+LAT1 amino acid permease F07C3.8 str-94;F07C3.8 Member of the 7-transmembrane chemoreceptor family of G protein-coupled receptors (GPCR), has low similarity to C. elegans ODR-10, which is involved in odorant response 7TM chemoreceptor, str family F07C3.9 F07C3.9 Protein of unknown function F07C4.1 F07C4.1 Member of the 7-transmembrane chemoreceptor family of G protein-coupled receptors (GPCR), has weak similarity to C. elegans ODR-10, which is involved in odorant response 7TM chemoreceptor, str family F07C4.10 F07C4.10 Protein containing one DUF18 domain of unknown function, has high similarity to uncharacterized C. elegans T05B4.12 F07C4.11 F07C4.11 Protein containing one DUF18 domain of unknown function F07C4.12 F07C4.12 Member of the carboxylesterase protein family carboxylesterase F07C4.13 F07C4.13 Member of the 7-transmembrane chemoreceptor family of G protein-coupled receptors (GPCR), has high similarity to uncharacterized C. elegans R03H4.9 7TM chemoreceptor, srh family F07C4.14 F07C4.14 Putative ortholog of C. elegans F08E10.1 gene product 7TM chemoreceptor, srh family F07C4.2 EF07C4.2;F07C4.2 Member of the C-type lectin family, has weak similarity to human C-type mannose receptor MRC1 F07C4.3 F07C4.3 G protein-coupled receptor, member of a subfamily with SRD proteins which are expressed in chemosensory neurons, no homolog found in human or D. melanogaster 7TM chemoreceptor, srd family F07C4.4 F07C4.4 Protein of unknown function, has high similarity to uncharacterized C. elegans F07C4.5 7TM chemoreceptor, srd family F07C4.5 F07C4.5 Protein of unknown function, has high similarity to uncharacterized C. elegans F07C4.8 7TM chemoreceptor, srd family F07C4.6 F07C4.6 Protein containing one DUF18 domain of unknown function, has high similarity to uncharacterized C. elegans F35E8.9 F07C4.7 F07C4.7 Protein of unknown function F07C4.8 F07C4.8 Protein of unknown function, has high similarity to uncharacterized C. elegans F07C4.5 7TM chemoreceptor, srd family F07C4.9 F07C4.9 Member of the C-type lectin family F07C6.1 pin-2;F07C6.1 LIM-only protein of the PINCH family of LIM-only proteins, putative paralog of C. elegans UNC-97, putative ortholog of human LIMS1 LIM domains F07C6.2 F07C6.2 Protein of unknown function F07C6.3 F07C6.3 Protein of unknown function, has high similarity to uncharacterized C. elegans C08F11.1 F07C6.4 F07C6.4 Protein of unknown function F07C7.1 F07C7.1 Member of the reverse transcriptase family, which are RNA-dependent DNA polymerases, contains a retroviral integrase core domain, which are central catalytic domains that can act as endonucleases, has high similarity to uncharacterized C. elegans T23B12.9 F07D10.1 F07D10.1 Protein with strong similarity to ribosomal protein L11 (human RPL11), which interacts with the cysteine proteinase bleomycin hydrolase (human BLML), member of the ribosomal L5 family, contains a ribosomal L5P C-terminal domain ribosomal protein; rpl-11.2 encodes a large ribosomal subunit L11 protein; by homology, RPL-11.2 is predicted to function in protein biosynthesis. F07D3.1 F07D3.1 Putative ortholog of C. elegans H24G06.1 gene product F07D3.2 flp-6;F07D3.2 KSAYMRF-amide neurotransmitter FMRFAMIDE-related peptide F07D3.3 F07D3.3 Protein with weak similarity to C. elegans T07F10.3 gene product F07E5.1 F07E5.1 Protein containing an F-box domain, which serve as a link between a target protein and a ubiquitin-conjugating enzyme This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins. F07E5.2 F07E5.2 Member of an uncharacterized protein family This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins; its encoded protein also contains a Pfam-B45 motif of presently unknown function. F07E5.4 F07E5.4 Protein with strong similarity to C. elegans T27E7.1 gene product F07E5.5 F07E5.5 Protein containing four zinc knuckle domains, which can bind eukaryotic RNA or DNA, has a region of low similarity to a region of S. pombe Byr3p, which is a DNA binding protein involved in conjugation and sporulation zinc-finger protein F07E5.6 F07E5.6 Putative ortholog of C. elegans F07E5.2 gene product F07E5.7 F07E5.7 Protein containing a DUF130 domain of unknown function, has high similarity to uncharacterized C. elegans R52.5 F07E5.8 F07E5.8 Protein containing one WSN domain of unknown function, has high similarity to uncharacterized C. elegans T16A1.2 F07E5.9 F07E5.9 Protein of unknown function F07F6.1 F07F6.1 Protein of unknown function F07F6.2 F07F6.2 Protein of unknown function F07F6.4 F07F6.4 Protein containing two putative arf GTPase activation (GAP) domains, which have C-4 class zinc fingers, has moderate similarity to ADP-ribosylation factor GTPase-activating protein 1 (human ARFGAP1), which is involved in the protein secretory pathway Zinc finger protein F07F6.5 F07F6.5 Protein with moderate similarity to C. elegans C29G2.6 gene product F07F6.6 nmr-1;F07F6.6 NMDA-type glutamate receptor, involved in locomotion behavior Glutamate receptor; nmr-1 encodes an NMDA-type ionotropic glutamate receptor subunit that affects the duration of forward movement which is important during foraging behavior, and also affects osmotic avoidance; the slow kinetics typical of NMDA-dependent currents are likely important for its effect on forward movement. F07F6.7 F07F6.7 Putative ortholog of C. elegans F07F6.8 gene product F07F6.8 F07F6.8 Putative ortholog of C. elegans F07F6.7 gene product F07F6.9 F07F6.9 Putative ortholog of C. elegans C14C11.5 gene product 7TM chemoreceptor, srx family F07G11.1 F07G11.1 Member of the domain of unknown function DUF13 family, has strong similarity to uncharacterized C. elegans C13A2.9 F07G11.2 F07G11.2 Member of the domain of unknown function DUF13 family, has strong similarity to uncharacterized C. elegans C13A2.10 F07G11.3 F07G11.3 Protein containing one DUF23 domain of unknown function, has high similarity to uncharacterized C. elegans F07G11.4 F07G11.4 F07G11.4 Protein containing one DUF23 domain of unknown function, has high similarity to uncharacterized C. elegans F07G11.3 F07G11.5 srj-32;F07G11.5 Member of the 7-transmembrane chemoreceptor family of G protein-coupled receptors (GPCR), has a region of weak similarity to C. elegans ODR-10, which is a G protein-coupled receptor involved in odorant response 7TM chemoreceptor, srj family F07G11.7 F07G11.7 Member of the domain of unknown function DUF13 family F07G11.8 F07G11.8 Protein of unknown function, has high similarity to uncharacterized C. elegans Y49C4A.4 7TM chemoreceptor, srx family F07G11.9 F07G11.9 Member of the glycosyl hydrolase 18 family, contains twelve LysM domains, which may bind peptidoglycans, has a region of low similarity to chitinase 1 (chitotriosidase, human CHIT1), which hydrolyzes chitin and is implicated in chitotriosidase deficiency F07G6.1 F07G6.1 Protein with moderate similarity to C. elegans F56C3.6 gene product F07G6.2 F07G6.2 Protein of unknown function F07G6.3 F07G6.3 Protein of unknown function, has high similarity to uncharacterized C. elegans Y67D8C.2 F07G6.5 F07G6.5 Protein of unknown function F07G6.6 F07G6.6 Protein containing one DUF38 domain of unknown function, has high similarity to uncharacterized C. elegans T12B5.10 F07G6.7 F07G6.7 Protein containing one DUF38 domain of unknown function F07G6.8 F07G6.8 Protein of unknown function F07H5.10 F07H5.10 Protein with weak similarity to C. elegans dom-3 gene product F07H5.12 F07H5.12 Protein of unknown function F07H5.13 F07H5.13 Protein of unknown function F07H5.2 F07H5.2 Protein with moderate similarity to delta sarcoglycan (mouse Sgcd), which is a component of the dystrophin-glycoprotein complex gamma-sarcoglycan F07H5.3 F07H5.3 Protein of unknown function F07H5.4 F07H5.4 Protein of unknown function F07H5.6 F07H5.6 Protein of unknown function F07H5.7 F07H5.7 Protein of unknown function F07H5.8 F07H5.8 Protein containing 22 uncharacterized DUF139 cysteine repeat domains, has low similarity to uncharacterized C. elegans C14C11.8 keratin like F07H5.9 F07H5.9 Member of the histidine acid phosphatase family, which hydrolyze phosphate esters at low pH, has low similarity to human ACP2, which is a tartrate-inhibitable lysosomal acid phosphatase acid phosphatase F08A10.1 F08A10.1 Protein containing a calmodulin binding domain, has a region of high similarity to Ca2+-activated small-intermediate conductance potassium channel 2 (human KCNN2), which is a voltage-independent K+ channel F08A8.1 F08A8.1 Member of the acyl-CoA oxidase family, which convert acyl-CoA into trans-2-enoyl-CoA, has moderate similarity to peroxisomal acyl-coenzyme A oxidase (rat RATACOA1), which catalyzes the first step in very long chain fatty acid beta-oxidation ACYL-COENZYME A OXIDASE, PEROXISOMAL (EC 1.3.3.6) (PALMITOYL-COA OXIDASE) (AOX); F08A8.1 is orthologous to the human gene ACYL-CoA OXIDASE 1, PALMITOYL (ACOX1; OMIM:264470), which when mutated leads to pseudoneonatal adrenoleukodystrophy. F08A8.2 F08A8.2 Member of the acyl-CoA oxidase family, which convert acyl-CoA into trans-2-enoyl-CoA, has moderate similarity to peroxisomal acyl-coenzyme A oxidase (rat RATACOA1), which catalyzes the first step in very long chain fatty acid beta-oxidation ACYL-COENZYME A OXIDASE, PEROXISOMAL (EC 1.3.3.6) (PALMITOYL-COA OXIDASE) (AOX) F08A8.3 F08A8.3 Member of the acyl-CoA oxidase family, which convert acyl-CoA into trans-2-enoyl-CoA, has moderate similarity to peroxisomal acyl-coenzyme A oxidase (rat RATACOA1), which catalyzes the first step in very long chain fatty acid beta-oxidation ACYL-COENZYME A OXIDASE, PEROXISOMAL (EC 1.3.3.6) (PALMITOYL-COA OXIDASE) (AOX) F08A8.4 F08A8.4 Member of the acyl-CoA oxidase family, which convert acyl-CoA into trans-2-enoyl-CoA, has moderate similarity to peroxisomal acyl-coenzyme A oxidase (rat RATACOA1), which catalyzes first step in very long chain fatty acid beta-oxidation ACYL-COENZYME A OXIDASE, PEROXISOMAL (EC 1.3.3.6) (PALMITOYL-COA OXIDASE) (AOX) F08A8.5 F08A8.5 Member of an uncharacterized protein family F08A8.6 F08A8.6 Protein containing an epsin N-terminal homology (ENTH) domain, has low similarity to a region of huntingtin interacting protein 1 related protein (mouse Hip1r), which binds F-actin, clathrin, and possibly phosphatidylinositol 4,5 bisphosphate F08A8.7 F08A8.7 Protein of unknown function, putative paralog of C. elegans C47B2.1 F08B1.1 vhp-1;F08B1.1 Protein containing two dual specificity phosphatase catalytic domains, has low similarity to human DUSP8, which is a dual specificity protein phosphatase that dephosphorylates and inactivates mitogen-activated protein kinase in vitro protein tyrosine phosphatase F08B1.2 gcy-12;F08B1.2 Guanylyl cyclase expressed in the PHA sensory neurons guanylate cyclase; gcy-12 encodes a predicted guanylate cyclase that affects chemotaxis to isoamyl alcohol; expressed in PHA neurons and in AFD neurons. F08B1.3 F08B1.3 Protein of unknown function F08B12.1 F08B12.1 Protein with weak similarity to prominin (mouse Prom), which is a cell surface antigen that may play roles in the establishment and maintenance of cell polarity and photoreceptor disk morphogenesis F08B12.1 is orthologous to the human gene AC133-2 ANTIGEN (PROML1; OMIM:604365), which when mutated leads to disease. F08B12.2 F08B12.2 Protein with moderate similarity to peroxisomal biogenesis factor 12 (human PEX12), which is a peroxisomal integral membrane protein that interacts with PXR1 and PEX10 and is involved in peroxisomal matrix protein import Zinc finger, C3HC4 type (RING finger) F08B12.3 slo-2;nSlo2;F08B12.3 Expressed in neurons and is a member of the calcium-activated Slo potassium channel family F08B12.4 F08B12.4;XM26 Protein of unknown function F08B4.1 F08B4.1 Protein of unknown function, has low similarity to uncharacterized deleted in cancer 1 (human DDX26), which is a candidate tumor suppressor that is downregulated in non-small cell lung carcinomas dic-1 encodes an ortholog of Drosophila CG3125 and human DEAD/H BOX 26 (DDX26, DICE-1; OMIM:604331; nuclear protein, lost or downregulated in nonsmall cell lung carcinomas); DIC-1 and its orthologs have an N-terminal von Willebrand factor (vWF) type A domain; DIC-1 is required for embryonic development and normal locomotion. F08B4.2 cdh-5;F08B4.2 Protein containing fourteen cadherin domains, which are found in the extracellular domain of some receptors and cell adhesion proteins, has weak similarity to a region of cadherin 23 (otocadherin, mouse Cdh23), which is involved in sensorineural hearing cadherin repeat-containing protein; a homolog of cadherin. F08B4.3 F08B4.3 Protein with moderate similarity to C. elegans wee-1.3 gene product F08B4.4 F08B4.4 Protein of unknown function F08B4.5 F08B4.5 Protein with low similarity to polymerase epsilon 2 (human POLE2), which is an accessory subunit of DNA polymerase epsilon that binds the catalytic subunit and stabilizes the polymerase complex F08B4.6 ndst;F08B4.6 Member of the sulfotransferase family, has moderate similarity to N-deacetylase N-sulfotransferase 1 (rat Ndst1), which is an enzyme that catalyzes N-deacetylation and N-sulfation of N-acetylglucosamine in heparan sulfate and heparin biosynthesis N-heparan sulfate sulfotransferase F08B4.7 F08B4.7 Protein with high similarity to small nuclear ribonucleoprotein polypeptide C (human SNRPC), which binds U1 snRNP particle and promotes the formation of the early spliceosomal complexes and is involved in transcriptional regulation U1 small nuclear ribonucleoprotein C F08B6.1 F08B6.F;F08B6.1 Protein of unknown function F08B6.2 gpc-2;F08B6.E;F08B6.2 Weakly similar to H. sapiens GNG11, guanine nucleotide binding protein 11; required to control mitotic spindle orientation gpc-2 encodes one of two C. elegans heterotrimeric G protein gamma subunits; gpc-2 is required, along with its partner GPB-1, a G protein beta subunit, for proper mitotic spindle positioning and orientation during early embryonic cell divisions; to date, GPC-2 expression has been reported in electrically excitable cells (all neurons and muscles). F08B6.3 F08B6.C;F08B6.3 Protein containing five EF hand domains, which are found in signaling, buffering or transport proteins, has low similarity to reticulocalbin 2 (rat Rcn2), which is an endoplasmic reticulum calcium-binding protein that binds the snake venom toxin taipoxin EF hand protein F08B6.4 unc-87;F08B6.B;F08B6.4 Actin-bundling protein; associated with muscle thin filaments calponin; unc-87 encodes, through alternative splicing, two proteins that are required to maintain the structure of myofilaments in body wall muscle cells; UNC-87 proteins resemble the C-terminal repeat region of calponin but have no obvious orthologs outside of nematodes; in vitro, UNC-87 proteins exist as monomers in solution, associate with thin (F-actin) filaments but not with monomeric G-actin, and bundle F-actin filaments; in vivo, UNC-87 proteins reside in the I-band of bodywall muscle, and GFP-tagged UNC-87 associates with actin stress fibers; unc-87 mutants show degeneration of myofilaments, are profoundly immobile, and have noticeable defects in egg-laying; the unc-87 mutant phenotype is partially suppressed by the unc-54(s95) mutation, which lowers myosin activity but leaves myofilaments intact, indicating that UNC-87 prevents damage by mechanical stress on myofilaments. F08C6.2 CCt;F08C6.2 CTP:phosphocholine cytidyltransferase cholinephosphate cytidylyltransferase; F08C6.2 encodes a lipid-activated CTP:phosphocholine cytidylyltransferase (CCT), with CCT activity in vitro; recombinant F08C6.2 enzyme is most activated by a 1:1 mixture of phosphatidylcholine:oleate vesicles; a inhibitory 21-residue segment (residues 246-266) is critical for specific activation of F08C6.2 by lipids, since deletion or mutation of this segment causes F08C6.2 to be constitutively active without its normal lipid substrate; F08C6.2 has no obvious function in mass RNAi assays. F08C6.3 F08C6.3 Protein of unknown function, has low similarity to uncharacterized suppressor of actin mutation 2-like (human SACM2L) F08C6.4 sto-1;F08C6.4 Protein with high similarity to erythrocyte membrane protein band 7.2 (stomatin, human EPB72), which may participate in ion channel permeability and mechanoreception and may be associated with stomatocytosis, member of the SPFH domain or Band 7 family Erythrocyte band 7 integral membrane protein (human) F08C6.5 F08C6.5 Protein of unknown function F08C6.6 F08C6.6 Protein with weak similarity to C. elegans Y39F10A.2 gene product F08C6.7 F08C6.7 Protein containing three C2H2 type zinc finger domains, which bind nucleic acids, has a region of low similarity to a region of zinc-finger protein 91 (human ZNF91), which functions as a transcriptional repressor Zinc finger; unc-98 encodes a protein with four C2H2 zinc fingers and several possible nuclear localization and export sequences; UNC-98 is required for normal mobility, M-line structures, and dense body (Z-line analog) structures; UNC-98 binds UNC-97/PINCH, HUM-6, and MEP-1; UNC-98 is located in M-lines, muscle cell nuclei, and perhaps dense bodies. F08D12.1 F08D12.1 Protein containing three TPR (tetratrico peptide repeat) domains, which may mediate protein-protein interactions, has low similarity to uncharacterized signal recognition particle 72 (human SRP72) signal recognition particle protein F08D12.10 F08D12.10 Protein containing an F-box domain, which serve as a link between a target protein and a ubiquitin-conjugating enzyme, has high similarity to uncharacterized C. elegans F08D12.9 This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins; its encoded protein also contains a Pfam-B45 motif of presently unknown function. F08D12.11 F08D12.11 Protein containing an F-box domain, which serve as a link between a target protein and a ubiquitin-conjugating enzyme, has moderate similarity to uncharacterized C. elegans F08D12.9 This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins; its encoded protein also contains a Pfam-B45 motif of presently unknown function. F08D12.12 F08D12.12 Protein of unknown function F08D12.13 F08D12.13 Protein of unknown function F08D12.2 F08D12.2 Protein of unknown function, has moderate similarity to uncharacterized C. elegans F08D12.3 F08D12.3 F08D12.3 Protein of unknown function, has moderate similarity to uncharacterized C. elegans F08D12.2 F08D12.4 F08D12.4 Putative ortholog of C. elegans F08D12.5 gene product F08D12.5 F08D12.5 Protein of unknown function, has strong similarity to C. elegans F08D12.4 F08D12.6 F08D12.6 Protein containing an F-box domain, which serve as a link between a target protein and a ubiquitin-conjugating enzyme This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins; its encoded protein also contains a Pfam-B45 motif of presently unknown function. F08D12.7 F08D12.7 Protein of unknown function, has low similarity to uncharacterized C. elegans F40G12.5 F08D12.8 F08D12.8 Protein containing an F-box domain, which serve as a link between a target protein and a ubiquitin-conjugating enzyme, has moderate similarity to uncharacterized C. elegans F29A7.1 This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins; its encoded protein also contains a Pfam-B45 motif of presently unknown function. F08D12.9 F08D12.9 Protein containing an F-box domain, which serve as a link between a target protein and a ubiquitin-conjugating enzyme, has high similarity to uncharacterized C. elegans F08D12.10 This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins; its encoded protein also contains a Pfam-B45 motif of presently unknown function. F08E10.1 F08E10.1 Member of the 7-transmembrane chemoreceptor family of G protein-coupled receptors (GPCR), has strong similarity to uncharacterized C. elegans T26H5.3 F08E10.2 F08E10.2 Protein containing one DUF40 domain of unknown function, which contain four conserved cysteines, has strong similarity to uncharacterized C. elegans T19C9.1 7TM receptor, srbc family F08E10.3 F08E10.3 Member of the 7-transmembrane chemoreceptor family of G protein-coupled receptors (GPCR), has high similarity to uncharacterized C. elegans Y102A5C.21 F08E10.4 F08E10.4 Member of the 7-transmembrane chemoreceptor family of G protein-coupled receptors (GPCR), has high similarity to uncharacterized C. elegans T19C9.4 F08E10.5 F08E10.5 Member of the 7-transmembrane chemoreceptor family of G protein-coupled receptors (GPCR), has strong similarity to uncharacterized C. elegans T19C9.3 F08E10.6 F08E10.6 Member of the 7-transmembrane chemoreceptor family of G protein-coupled receptors (GPCR), has strong similarity to uncharacterized C. elegans T19C9.2 F08E10.7 F08E10.7 Member of an uncharacterized protein family F08F1.1 kin-9;F08F1.1 Protein containing two protein kinase domains, has a region of moderate similarity to a region of fibroblast growth factor receptor 4 (human FGFR4), which is a receptor protein tyrosine kinase that binds acidic FGF and functions in cell differentiation protein-tyosine kinase; kin-9 encodes a predicted protein tyrosine kinase. F08F1.3 F08F1.3 Protein of unknown function F08F1.4 F08F1.4 Protein of unknown function F08F1.5 ced-8;F08F1.5 Appears to have a role in the modulation of the kinetics of cell corpse engulfment during development The ced-8 gene encodes a homolog of the human putative membrane transporter XK; ced-8 is required for apoptosis to occur with normal speed during embryonic development. F08F1.6 F08F1.6 Protein of unknown function F08F1.7 F08F1.7;Emp70 Member of the COPII coat protein, Emp70p-like protein family F08F1.8 F08F1.8 Protein with weak similarity to D. melanogaster EG:EG0007.11 F08F1.9 F08F1.9 Protein containing a cyclin N-terminal domain, has a region of high similarity to a region of cyclin A2 (human CCNA2), which is a CDK regulatory subunit that binds human CDK2 and human CDC2 to promote cell cycle G1/S and G2/M phase transition F08F3.1 F08F3.1 Protein of unknown function F08F3.2 F08F3.2 Member of the phospholipid and glycerol acyltransferase family, has low similarity to mitochondrial glycerol-3-phosphate acyltransferase (mouse Gpam), which catalyzes the first step in triacylglycerol and phospholipid biosynthesis glycerol-3-phosphate acyltransferase F08F3.3 rhr-1;F08F3.3 Member of the ammonium transporter family, has moderate similarity to rhesus blood group-associated glycoprotein (human RHAG), which is a component of the Rh antigen that plays a role in the antigen transport to the cell surface blood group RH(D) polypeptide; rhr-1 encodes an ortholog of human Rhesus blood-group associated glycoprotein (RHAG; OMIM:180297, mutated in chronic hemolytic anemia), a member of the ammonium transporter family, and affects general levels of mRNA transcripts, and embryonic viability in a large-scale RNAi screen. F08F3.4 F08F3.4 Protein of unknown function F08F3.6 F08F3.6 Protein containing an F-box domain, which serve as a link between a target protein and a ubiquitin-conjugating enzyme, has moderate similarity to uncharacterized C. elegans T10C6.10 This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins. F08F3.7 F08F3.7 Member of the cytochrome P450 family, has low similarity to cytochrome P450 subfamily 2J polypeptide 2 (human CYP2J2), which is an arachidonic acid epoxygenase cytochrome P450; ccp-14A5 encodes a member of the cytochrome P450 family. F08F3.8 F08F3.8 Protein with moderate similarity to C. elegans T20H9.6 gene product F08F3.9 F08F3.9 Protein of unknown function, putative paralog of C. elegans Y39E4B.K and C. elegans R05F9.11 F08F8.1 F08F8.1 Putative ortholog of C. elegans F08F8.5 gene product F08F8.10 F08F8.10 Protein with moderate similarity to C. elegans F08F8.9 gene product F08F8.2 F08F8.2 Member of the hydroxymethylglutaryl-coenzyme A reductase family, which catalyze NADP-dependent synthesis of mevalonate, has high similarity to a region of 3-hydroxy-3-methylglutaryl-Coenzyme A reductase (human HMGCR) Hydroxymethylglutaryl-coA reductase F08F8.3 kap-1;F08F8.3 Likely a kinesin associated protein that contains an armadillo consensus motif, forms a complex with KLP-11 and OSM-3, and may have a role in signal transduction F08F8.4 eco-1;F08F8.4 Protein with weak similarity to S. cerevisiae Yfr027p, which is required to establish cohesion between sister chromatids during DNA replication F08F8.5 F08F8.5 Putative ortholog of C. elegans F08F8.1 gene product F08F8.6 F08F8.6 Protein with weak similarity to C. elegans T23E7.2 gene product F08F8.7 F08F8.7 Protein of unknown function F08F8.8 F08F8.8 Protein of unknown function F08F8.9 F08F8.9 Protein with moderate similarity to C. elegans F08F8.10 gene product F08G12.1 F08G12.1 Protein with weak similarity to C. elegans W03C9.3 (GTP-binding protein of the rab family (ras superfamily)) ras-related like protein F08G12.10 inx-2;innexin;F08G12.10;XL914 Member of the OPUS/Innexin, gap junction, protein family; strongly similar to C. elegans INX-3 innexin F08G12.2 opu-2;inx-2;F08G12.2 Protein with high similarity to human HPRP8BP, which is a U5 snRNP-specific 40 kD protein and a component of the U5 small nuclear ribonucleoprotein particle that binds to the 220 kDa component human PRPF8, contains seven WD domains (WD-40 repeat) WD domain, G-beta repeat (6 domains) F08G12.3 F08G12.3 Protein of unknown function F08G12.4 F08G12.4 Protein of unknown function vhl-1 is orthologous to the mammalian tumor suppressor gene Von Hippel-Landau syndrome (VHL; OMIM:193300), which is part of a ubiquitylation complex targetting proteins for proteasomal degradation. F08G12.5 F08G12.5 Protein containing a C3HC4 type (RING) zinc finger, which may mediate protein-protein interactions Zinc finger, C3HC4 type (RING finger) F08G12.6 F08G12.6 TcA transposase Tc1 transposase F08G12.8 F08G12.8 Protein of unknown function F08G2.1 F08G2.1 Member of the histone H2B protein family Core histones H2A, H2B, H3 and H4; his-44 encodes an H2B histone. F08G2.2 F08G2.2 Protein with very strong similarity to C. elegans HIS-16, which is involved in cell migration, DNA packaging, and the regulation of body size, member of the histone family of nucleosomal core proteins Core histones H2A, H2B, H3 and H4; his-43 encodes an H2A histone. F08G2.3 F08G2.3 Member of the histone H3 protein family Core histones H2A, H2B, H3 and H4; his-42 encodes an H3 histone. F08G2.4 F08G2.4;2O123 Protein of unknown function F08G2.5 F08G2.5 Protein of unknown function F08G2.6 F08G2.6 Protein of unknown function F08G2.7 F08G2.7 Protein of unknown function, has moderate similarity to C. elegans C17E7.4 F08G2.8 F08G2.8 Protein of unknown function F08G5.1 F08G5.1 Protein of unknown function F08G5.2 F08G5.2 Protein of unknown function, has moderate similarity to uncharacterized C. elegans C01C10.3 F08G5.3 F08G5.3 Protein of unknown function F08G5.4 F08G5.4 Protein containing two collagen triple helix repeats, which are found in some extracellular proteins, and a nematode cuticle collagen N-terminal domain, has a region of high similarity to a region of C. elegans BLI-1 collagen F08G5.5 F08G5.5 Protein that shares a region of strong similarity with UDP glycosyltransferases, member of the C-type lectin family UDP-glucuronyltransferase like F08G5.6 F08G5.6 Member of an uncharacterized protein family F08H9.1 coh-3;F08H9.1 Protein of uknown function, has strong similarity to uncharacterized C. elegans Y45G5AM.8 coh-3 encodes a member of the Rad21/Rec8-like family of cohesion proteins that is expressed in the germline; an effect on embryonic viability has been reported based on some RNAi screens, but has not been demonstrated in others. F08H9.2 F08H9.2 Protein of unknown function F08H9.3 F08H9.3 Protein with high similarity to C. elegans F08H9.4, which is involved in the heat shock response, member of the Hsp20 or alpha crystallin family heat shock protein; F08H9.3 encodes a heat shock protein (HSP) of the HSP16 class; unlike most HSP16s in C. elegans, it is specifically expressed in a particular tissue (the larval pharynx and the anterior adult pharynx), and its expression is not strongly induced by heat shock; however, F08H9.3 expression is increased by heat shock (with adult expression in the full pharynx) and probably aids heat shock resistance, since F08H9.3(RNAi) animals have sensitivity to heat shock that is sporadically higher than normal; in general, HSP16 proteins are thought to act as passive ligands for unfolded proteins that keep them safe from aggregation until the proteins can be refolded by a large (ATP-consuming) HSP. F08H9.4 F08H9.4 Protein with high similarity to C. elegans HSP-16, which is involved in the heat shock response, member of the Hsp20 or alpha crystallin family heat shock protein; F08H9.4 encodes a heat shock protein (HSP) of the HSP16 class; unlike most HSP16s in C. elegans, it is specifically expressed in a particular tissue (the excretory canal and ventral nerve-cord neurons), and its expression is only mildly induced by heat shock; however, F08H9.4 expression is increased by heat shock, is induced in a new tissue type (intestine) by heat shock, and probably aids heat shock resistance, since F08H9.4(RNAi) animals die as embryos in heat shock at a higher rate than normal; in general, HSP16 proteins are thought to act as passive ligands for unfolded proteins that keep them safe from aggregation until the proteins can be refolded by a large (ATP-consuming) HSP. F08H9.5 F08H9.5 Member of the C-type lectin domain protein family C-type lectin domain F08H9.6 F08H9.6 Member of the C-type lectin domain protein family C-type lectin domain F08H9.7 F08H9.7 Member of the C-type lectin domain protein family C-type lectin domain F08H9.8 F08H9.8 Member of the C-type lectin domain protein family C-type lectin domain F08H9.9 F08H9.9 Protein containing two CUB domains and a C-type lectin domain, has a region of low similarity to a region of cubilin (intrinsic factor-cobalamin receptor, human CUBN), which mediates HDL endocytosis and is associated with hereditary megaloblastic anemia 1 F09A5.1 F09A5.1 Member of the major facilitator superfamily (MFS) protein family tetracycline resistance like protein F09A5.2 F09A5.2 Protein containing three protein kinase domains, has a region of low similarity to a region of a tyrosine protein kinase (C. elegans EGL-15) tyrosine-protein kinase F09A5.3 F09A5.3 Protein of unknown function F09A5.4 F09A5.4 Protein of unknown function, has a region of low similarity to S. pombe Mob1p, which is an essential protein involved in cytokinesis and septum formation F09B12.1 F09B12.1 Protein with moderate similarity to C. elegans Y43D4A.F gene product F09B12.2 F09B12.2 Protein containing a DHHC-type zinc finger (NEW1) domain F09B12.3 F09B12.3 Protein of unknown function, has moderate similarity to uncharacterized C. elegans Y37D8A.2 F09B12.4 F09B12.4 Protein of unknown function F09B12.5 F09B12.5 Protein containing three low-density lipoprotein (LDL) receptor class A domains, has a region of low similarity to a region of very low density lipoprotein receptor (human VLDLR), which acts in metabolism of liproteins and is linked to Alzheimer disease Low-density lipoprotein receptor domain class A (2 domains) F09B9.1 F09B9.1 Member of the uncharacterized protein family UPF0063, has high similarity to uncharacterized C. elegans F52F10.4 F09B9.2 unc-115;F09B9.2 Putative actin-binding protein required for proper axon guidance LIM domains; unc-115 encodes a protein that binds actin filaments and that is required for RAS signalling and UNC-40/netrin activity during axon pathfinding. F09B9.3 ERD2;F09B9.3 Protein with high similarity to KDEL endoplasmic reticulum protein retention receptor 1 (human KDELR1), which is involved in retention of proteins in the endoplasmic reticulum, member of the endoplasmic reticulum lumen protein retaining receptor family ER lumen protein retaining receptor; erd-2 encodes a protein with homology to human ER lumen protein retaining receptor 1. F09B9.4 F09B9.4 Protein with weak similarity to S. cerevisiae YDL099W F09C11.1 F09C11.1 Protein of unknown function F09C12.1 gbr-6;F09C12.1 Protein containing neurotransmitter-gated ion-channel ligand binding and transmembrane domains, has low similarity to alpha 3 subunit of the inhibitory glycine receptor (rat Glra3), which may play a role in neuronal differentiation and excitability Glycine receptor alpha chain; ggr-3 encodes a predicted member of the GABA/ glycine receptor family of ligand-gated chloride channels; expressed in the AVA, AVB, SMDD, DVA, SIAD, and in some other neurons of the nerve ring. F09C12.2 F09C12.2 Protein containing a protein kinase domain, has a region of high similarity to S. pombe Spk1p, which is a mitogen-activated protein kinase acting in the mating and sporulation pathways Ser/Thr protein kinase F09C12.6 F09C12.6 Protein of unknown function, has moderate similarity to C. elegans C30B5.7 F09C12.7 F09C12.7 Protein of unknown function, has very strong similarity to a region of C. elegans MSP-10 msp-74 encodes a protein that belongs to a family of proteins called the Major Sperm Proteins (MSPs) that is conserved in nematodes; this family consists of closely related, small, basic proteins that make up 15% of sperm protein; this multigene family consists of over fifty genes, including many pseudogenes; MSPs are involved in both extracellular signaling and cytoskeletal functions during reproduction-MSP antagonizes Eph/ephrin signaling, in part, by binding VAB-1 Eph receptor tyrosine kinase on oocytes and sheath cells to promote oocyte maturation and MAPK activation; MSPs assemble into fibrous networks that drive movement of the C. elegans sperm; msp genes are expressed only in late primary spermatocytes. F09C3.1 F09C3.1 Protein containing two IQ calmodulin-binding domains, has weak similarity to IQ motif containing GTPase activating protein 2 (human IQGAP2), which inhibits GTPase activity of human CDC42 and RAC1 and may bind actin and help regulate cell shape ras GTPase-activating protein like; pes-7 encodes an ortholog of the vertebrate IQGAP proteins, actin- and CLIP-170-binding proteins that serve as effectors for the Rho family GTPases Rac1 and Cdc42; IQGAP's alpha-actinin domain is related distantly to alpha-actinin domains in calponin, transgelin (SM22 alpha), and the proto-oncogene Vav; pes-7 was identified in promoter-trapping screens and by homology, is predicted to function as a key regulator of cytoskeletal organization in migrating cells and as a regulator of cadherin-mediated cell-cell adhesion; however, PES-7 has no obvious function in mass RNAi assays; a pes-7 reporter is first expressed in the ventral nerve cord of the elongating embryo and in later stages of development is also expressed in all major ganglia, the vulva, and in the spermathecal valves; in the ventral nerve cord, pes-7 expression is detected in nuclei as well as in cell bodies and neural processes. F09C3.2 F09C3.2 Member of the haloacid dehalogenase or epoxide hydrolase family haloacid dehalogenase-like hydrolase; This gene encodes a protein predicted by Eisenberg and coworkers, with 52% accuracy, to be mitochondrial. F09C3.3 F09C3.3 Protein containing an F-box domain, which serve as a link between a target protein and a ubiquitin-conjugating enzyme, has high similarity to uncharacterized C. elegans F09C3.5 This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins; its encoded protein also contains a Pfam-B45 motif of presently unknown function. F09C3.4 F09C3.4 Protein containing a DUF38 domain of unknown function and an F-box domain, which serve as a link between a target protein and a ubiquitin-conjugating enzyme, has high similarity to uncharacterized C. elegans T06E6.13 This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins; this gene's encoded protein also contains an FTH/DUF38 motif, which may also mediate protein-protein interaction. F09C3.5 F09C3.5 Protein of unknown function, putative paralog of C. elegans F09C3.3 F09C3.6 F09C3.6 Putative paralog of C. elegans Y58G8A.2 reverse transcriptase F09C6.1 F09C6.1 Protein of unknown function, has strong similarity to C. elegans F40H7.4 F09C6.10 F09C6.10 Protein with strong similarity to C. elegans D1086.6 gene product F09C6.2 F09C6.2 Protein containing a DUF38 domain of unknown function and an F-box domain, which serve as a link between a target protein and a ubiquitin-conjugating enzyme, has high similarity to uncharacterized C. elegans F09C6.6 This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins; this gene's encoded protein also contains an FTH/DUF38 motif, which may also mediate protein-protein interaction. F09C6.3 F09C6.3 Protein of unknown function F09C6.4 F09C6.4 Member of the serpin family of serine protease inhibitors, has low similarity to human SERPINB8, which is an inhibitor of furin (human PACE), thrombin (human F2), factor Xa (human F10) and other trypsin-like and chymotrypsin-like proteinases Serpins (serine protease inhibitors) (2 domains) F09C6.5 F09C6.5 Member of the serpin family of serine protease inhibitors, has low similarity to human SERPINB8, which is an inhibitor of furin (human PACE), thrombin (human F2), factor Xa (human F10) and other trypsin-like and chymotrypsin-like proteinases Serpins (serine protease inhibitors) (2 domains) F09C6.6 F09C6.6 Protein containing a DUF38 domain of unknown function and an F-box domain, which serve as a link between a target protein and a ubiquitin-conjugating enzyme, has high similarity to uncharacterized C. elegans F09C6.2 This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins; this gene's encoded protein also contains an FTH/DUF38 motif, which may also mediate protein-protein interaction. F09C6.7 F09C6.7 G protein-coupled receptor, member of a subfamily with SRD proteins which are expressed in chemosensory neurons, no homolog found in human or D. melanogaster F09C6.8 F09C6.8 Protein containing a nuclear hormone receptor ligand-binding domain and C4-type zinc finger domain, which bind DNA and may be involved in regulation of transcription, has low similarity to hepatocyte nuclear factor 4 alpha (human HNF4A) Zinc finger, C4 type (two domains) F09C6.9 F09C6.9 Protein containing a nuclear hormone receptor C4-type zinc finger domain, which may be involved in regulation of transcription, and a nuclear hormone receptor ligand-binding domain, has low similarity to retinoic acid receptor gamma (mouse Rarg) nuclear hormone receptor F09C8.1 F09C8.1 Member of the lipase or acylhydrolase family, has moderate similarity to a region of intestinal phospholipase B-lipase (rat PLB-LIP), which has phospholipase A2, lysophospholipase, and triacylglycerol lipase activity phospholipase precursor F09C8.2 F09C8.2 Protein of unknown function F09D1.1 F09D1.1 Protein containing a ubiquitin carboxyl-terminal hydrolases family 2 domain and a Zn-finger in ubiquitin-hydrolases and other proteins domain, has low similarity to S. cerevisiae Sad1p, which is required for pre-mRNA splicing and for snRNP assembly ubiquitin protease F09D12.1 grd-10;F09D12.1 Protein of unknown function, has strong similarity to C. elegans GRD-5 grd-10 encodes a protein that contains a novel Ground domain that is closely related to GRD-5. F09D12.2 F09D12.2 Member of the M13 peptidase family of zinc metalloproteases, has high similarity to uncharacterized C. elegans Y19D10B.6 F09D12.2 encodes a neprilysin; neprilysins are thermolysin-like zinc metallopeptidases, found on the outer surface of animal cells, that negatively regulate small signalling peptides (e.g., enkephalin, tachykinin, insulin, and natriuretic peptides) by cleaving them; F09D12.2 has no clear orthologs in other organisms. F09E10.1 F09E10.1 Protein of unknown function F09E10.3 F09E10.3 Protein with high similarity to mouse H2-Ke6, which is a 17-beta dehydroxysteroid dehydrogenase that is involved in androgen or estrogen metabolism, member of the short-chain dehydrogenase-reductase family, which are NAD- or NADP-dependent oxidoreductases short-chain alcohol dehydrogenase; dhs-25 encodes a short-chain dehydrogenase predicted to be mitochondrial. F09E10.5 F09E10.5 Protein of unknown function F09E10.6 F09E10.6 Protein with weak similarity to C. elegans F55C12.7 gene product F09E10.7 F09E10.7 Protein of unknown function, has weak similarity to C. elegans R102.1 F09E10.8 F09E10.8 Putative paralog of C. elegans K08E3.3, has similarity to human Hs.73999, CDC42-interacting protein 4 F09E5.1 pkc-3;F09E5.1 Serine/threonine protein kinase; has strong similarity to human, D. melanogaster, and S. cerevisiae atypical protein kinase C isoforms; important for establishment of embryonic polarity Protein kinase C F09E5.10 F09E5.10 Protein of unknown function, has very strong similarity to uncharacterized C. elegans Y43F4B.2, which is predicted to be a ubiquitin carboxyl-terminal hydrolase F09E5.11 F09E5.11 Protein of unknown function F09E5.12 F09E5.12 Protein of unknown function F09E5.13 agt-2;F09E5.13 O6-alkylguanine DNA-alkyltransferase, implicated in alkyl transfer-mediated DNA repair agt-2 encodes a paralog of the DNA repair enzyme O6-Alkylguanine DNA-alkyltransferase (AGT); AGT-2 has AGT biochemical activity and is expressed at all developmental stages. F09E5.2 F09E5.2 Putative member of the thioredoxin peroxidase/thiol-specific antioxidant AHPC/TSA protein F09E5.3 F09E5.3 Member of deoxyribose-phosphate aldolase, which may be involved in nucleotide metabolism, has high similarity to uncharacterized human LOC51071 Deoxyribose-phosphate aldolase F09E5.4 F09E5.4 Protein with weak similarity to C. elegans T09D3.5 gene product 7TM chemoreceptor, srg family F09E5.5 F09E5.5 Protein with weak similarity to tumor necrosis factor alpha-induced protein 2 (human TNFAIP2), which plays a role in myeloid development and is a target gene of promyelocytic leukemia retinoic acid receptor in acute promyelocytic leukemia F09E5.7 F09E5.7 Protein of unknown function F09E5.8 F09E5.8 Member of the uncharacterized protein family UPF0001, has high similarity to uncharacterized proline synthetase co-transcribed (mouse Prosc) F09E5.9 F09E5.9 Protein of unknown function, putative paralog of C. elegans F09E5.10 F09E8.1 F09E8.1 Protein containing a DX module domain F09E8.2 F09E8.2;msh-5 Protein of unknown function, has a region of low similarity to a region of very low density lipoprotein receptor (human VLDLR), which mediates transport and metabolism of liproteins F09E8.3 msh-5;F09E8.3 Protein required for meiotic recombination and chiasma formation, member of the MutS family of proteins Yeast DNA mismatch repair protein MSH5 like; msh-5 encodes a germline-specific homolog of the yeast and mammalian DNA mismatch repair protein MSH5 (MutS-family) that is required for crossing over and chiasma formation during Caenorhabditis elegans meiosis; inactivation of both rad-51 and msh-5 induces chromosome fragmentation, not seen with inactivation of either gene alone. F09E8.5 F09E8.5 Member of the SCP-like extracellular protein family, has low similarity to specific granule protein 28kDa (human SGP28), which is a glycoprotein that is widely expressed and localizes to specific granules in neutrophils testis-specific protein TPX-1 like F09E8.6 F09E8.6 Member of the astacin (M12A) family of metalloproteases, has a region of moderate similarity to a region of bone morphogenetic protein 1 (human BMP1), which is a metalloprotease that cleavages C-propeptides of procollagens I, II, and III zinc metalloprotease F09E8.7 lev-1;acr-1;F09E8.7 Putative "non-alpha" subunit of a nicotine acetylcholine receptor acetylcholine receptor; lev-1 encodes an alpha subunit of nicotinic acetylcholine receptor (nAChR) which, when mutated, confers resistance to levamisole; LEV-1 is required for completely normal locomotion, and forms a cation channel when coexpressed with UNC-38 or UNC-63 and UNC-29; LEV-1 falls into the 'UNC-29' class of nAChR subunits, which includes UNC-29, ACR-2, and ACR-3. F09F3.1 F09F3.1 Member of the G protein-coupled receptor protein family G-protein coupled receptor F09F3.10 F09F3.10 Protein containing a nuclear hormone receptor C4-type zinc finger domain, which bind DNA, and a nuclear hormone receptor ligand-binding domain, has low similarity to nuclear receptor subfamily 2 group F member 6 (rat Rn.25840) Ligand-binding domain of nuclear hormone receptors, Zinc finger, C4 type (two domains) F09F3.11 F09F3.11 Protein of unknown function, has moderate similarity to uncharacterized C. elegans F09F3.13 7TM receptor, srx family F09F3.12 F09F3.12 Member of the G protein-coupled receptor protein family 7TM receptor, srx family F09F3.13 F09F3.13 Protein of unknown function, has moderate similarity to uncharacterized C. elegans F09F3.12 7TM receptor, srx family F09F3.2 F09F3.2 Member of the G protein-coupled receptor protein family 7TM receptor, srx family F09F3.3 F09F3.3 Protein of unknown function, has high similarity to uncharacterized C. elegans F09F3.2 F09F3.4 F09F3.4 Member of the G protein-coupled receptor protein family 7TM receptor, srx family F09F3.5 F09F3.5 Member of the animal heme peroxidase family, has low similarity to myeloperoxidase (mouse Mpo), which mediates neutrophil and monocyte microbicidal activity and may have a role in atherosclerosis peroxidase like F09F3.6 F09F3.6 Member of the transthyretin-like family, has high similarity to uncharacterized C. elegans T04H1.3 Transthyretin-like family F09F3.7 F09F3.7 Protein of unknown function, has low similarity to uncharacterized C. elegans F09F3.12 7TM receptor, srx family F09F3.9 F09F3.9 Member of the choline or carnitine o-acyltransferase family, has low similarity to liver carnitine palmitoyltransferase I (rat Cpt1a), which acts in long-chain fatty acid beta-oxidation and influences energy production, cell signaling and apoptosis carnitine palmitoyltransferase like F09F7.1 F09F7.1 Protein of unknown function F09F7.2 mlc-3;F09F7.2 Protein with high similarity to myosin light chain 1 (alkali, human MLC1), which is a structural protein of myosin that may regulate the molecular motor activity for muscle contraction by modulating actin binding, contains two EF hand domains F09F7.3 F09F7.3 Protein with high similarity to the RNA polymerase III second-largest subunit (C128, S. cerevisiae Ret1p), member of the RNA polymerases beta subunit family, which are shared among all three types of eukaryotic RNA polymerases F09F7.4 F09F7.4 Protein with high similarity to beta-hydroxyisobutyryl-coenzyme A hydrolase (human HIBCH), which acts in valine catabolism by hydrolyzing 3-hydroxyisobutyryl CoA, member of the enoyl-CoA hydratase or isomerase family Enoyl-CoA hydratase F09F7.5 F09F7.5 Protein of unknown function F09F7.6 F09F7.6 Protein of unknown function F09F7.7 F09F7.7 Protein of unknown function, has low similarity to uncharacterized human FLJ20013 F09F7.8 F09F7.8 Protein of unknown function, has weak similarity to C. elegans F35C5.10 F09F9.1 F09F9.1 Protein of unknown function F09F9.2 F09F9.2 Protein of unknown function, has weak similarity to C. elegans F16F9.2 F09F9.3 F09F9.3 Protein of unknown function F09F9.4 F09F9.4 Protein containing a type 1 thrombospondin domain, has a region of high similarity to a region of thrombospondin 2 (human THBS2), which is an adhesive molecule that binds heparin and plays roles in cell adhesion and inhibition of angiogenesis Type I thrombospondin (TSP) repeats F09G2.1 F09G2.1 Protein containing a protein kinase domain, has a region of low similarity to a region of a tyrosine protein kinase (C. elegans EGL-15) tyrosine protein kinase F09G2.2 F09G2.2 Protein of unknown function F09G2.3 F09G2.3 Member of the phosphate transporter family, has low similarity to solute carrier family 20 member 1 (human SLC20A1), which is a high-affinity sodium-inorganic phosphate cotransporter that plays a role in phosphate transport and metabolism permease F09G2.4 F09G2.4 Protein with moderate similarity to cleavage and polyadenylation specificity factor 2 (mouse Cpsf2), which is a subunit of the general polyadenylation factor and a poly(A)-binding protein that is likely to play a role in mRNA polyadenylation F09G2.5 F09G2.5 Protein containing neurotransmitter-gated ion-channel ligand binding and transmembrane domains, has low similarity to alpha 3 subunit of the inhibitory glycine receptor (rat Glra3), which may play a role in neuronal differentiation and excitability ion channel protein F09G2.6 F09G2.6 Protein containing two UDP-glucoronosyl and UDP-glucosyl transferase domains, has low similarity to UDP glycosyltransferase 1 family polypeptide A1 (human UGT1A), which acts in bilirubin conjugation and has a role in Gilbert and Crigler-Najjar syndromes F09G2.7 F09G2.7 Member of the 7-transmembrane chemoreceptor family of G protein-coupled receptors (GPCR), has high similarity to uncharacterized C. elegans C44C3.9 7TM chemoreceptor, srh family F09G2.8 F09G2.8 Protein containing two phospholipase D active site motifs, has moderate similarity to uncharacterized phospholipase D3 (mouse Pld3), which may play a role in signal transduction and neurogenesis F09G2.9 F09G2.9 Protein of unknown function, has weak similarity to human nuclear autoantigenic sperm protein NASP, has weak similarity to S. cerevisiae Chs5p (required for chitin synthase III activity) F09G8.1 F09G8.1 Protein of unknown function F09G8.2 YLS2;F09G8.2 Protein with strong similarity to H. sapiens DNase II, a lysosomal deoxyribonuclease II F09G8.3 F09G8.3 Protein with moderate similarity to the amino terminus of H. sapiens NPC1, a protein involved in Niemann-Pick disease F09G8.4 npc-2;F09G8.4 Member of the patched family, which are transmembrane receptors, has low similarity to C. elegans NPC-1, which functions in cholesterol metabolism and possibly general vesicular trafficking ncr-2 encodes a homolog of human NPC1, which when mutated leads to Niemann-Pick disease, type C (OMIM:257220). F09G8.5 F09G8.5 Protein containing leucine rich repeats, which mediate protein-protein interactions F09G8.6 F09G8.6 Protein containing two collagen triple helix repeats, which are found in some extracellular proteins and nematode cuticle collagen N-terminal domain, has high similarity to a region of C. elegans BLI-1 Cuticle collagen F09G8.7 F09G8.7 Protein of unknown function F09G8.8 F09G8.8 Member of the lectin C-type domain containing protein family F09G8.9 F09G8.9 Protein of unknown function, has moderate similarity to C. elegans F09G8.8 F10A3.1 F10A3.1 Protein of unknown function, has high similarity to uncharacterized C. elegans F44G3.10 F10A3.1 encodes a claudin homolog that may be required for normal cohesion of apical junctions in epithelia; F10A3.1 is worm-specific, with obvious homologs only in C. elegans; F10A3.1 has no obvious function in mass RNAi assays; claudins are integral membrane proteins with four transmembrane sequences that are found in mammalian tight junctions (TJs), induce TJs when transgenically expressed in cells normally lacking them, and can mediate the specific conductance of of specific ions (e.g., magnesium or calcium) through TJs while blocking the flow of water. F10A3.11 F10A3.11 Protein of unknown function, has low similarity to uncharacterized C. elegans T07D3.2 F10A3.12 F10A3.12 Member of the 7-transmembrane chemoreceptor family of G protein-coupled receptors (GPCR), has low similarity to C. elegans ODR-10, which is a G protein-coupled receptor involved in odorant response F10A3.13 F10A3.13 Member of the 7-transmembrane chemoreceptor family of G protein-coupled receptors (GPCR), has low similarity to C. elegans ODR-10, which is a G protein-coupled receptor involved in odorant response F10A3.15 F10A3.15 Member of the 7-transmembrane chemoreceptor family of G protein-coupled receptors (GPCR), has weak similarity to C. elegans ODR-10, which is a G protein-coupled receptor involved in odorant response F10A3.2 F10A3.2 Protein containing a DUF38 domain of unknown function and an F-box domain, which serve as a link between a target protein and a ubiquitin-conjugating enzyme, has low similarity to C. elegans FOG-2 This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins; this gene's encoded protein also contains an FTH/DUF38 motif, which may also mediate protein-protein interaction. F10A3.3 F10A3.3 Protein containing an F-box domain, which serve as a link between a target protein and a ubiquitin-conjugating enzyme This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins. F10A3.5 F10A3.5 Member of the 7-transmembrane chemoreceptor family of G protein-coupled receptors (GPCR), has low similarity to C. elegans ODR-10, which is a G protein-coupled receptor involved in odorant response F10A3.6 F10A3.6 Member of the 7-transmembrane chemoreceptor family of G protein-coupled receptors (GPCR), has low similarity to C. elegans ODR-10, which is a G protein-coupled receptor involved in odorant response F10A3.7 F10A3.7 Member of the 7-transmembrane chemoreceptor family of G protein-coupled receptors (GPCR), has low similarity to a region of C. elegans ODR-10, which is a G protein-coupled receptor involved in odorant response F10A3.8 F10A3.8 Member of the 7-transmembrane chemoreceptor family of G protein-coupled receptors (GPCR), has low similarity to C. elegans ODR-10, which is a G protein-coupled receptor involved in odorant response F10A3.9 F10A3.9 Member of the 7-transmembrane chemoreceptor family of G protein-coupled receptors (GPCR), has high similarity to uncharacterized C. elegans C05E4.13 F10B5.1 F10B5.1 Protein with high similarity to human RPL10, which is a structural ribosomal protein, member of the ribosomal L10e family, which are part of the large ribosomal subunit ribosomal protein L10 (QM protein); rpl-10 encodes a large ribosomal subunit L10 protein required in mass RNAi assays for embryonic viability, fertility, normally rapid growth, and normal body coloration; the rpl-10 transcription unit has a nonsense transcript that is up-regulated in vivo by smg[-] mutations, indicating that rpl-10 is a natural substrate for SMG-mediated nonsense suppresssion; several other natural mRNA substrates of SMG suppression (e.g., rpl-3, rpl-7, rpl-12) have protein products that are involved in translation. F10B5.2 F10B5.2 Protein of unknown function F10B5.3 F10B5.3 Protein containing three C2H2 type zinc finger domains, which bind nucleic acids Zinc finger, C2H2 type F10B5.4 tub-1;F10B5.4 Member of the Tub family, has moderate similarity to tubby (mouse Tub), which is a transcription factor that is associated with obesity and sensory deficits and may play roles in the insulin receptor signaling and G protein signaling pathways Tub family protein tub-1; tub-1 encodes a tubby homolog that affects fat storage in C. elegans and may function in a parallel pathway with kat-1 to affect lipid accumulation based on genetic analysis; expressed primarily in sensory neurons. F10B5.5 F10B5.5 Member of the ATPase family associated with various cellular activities, has moderate similarity to thyroid hormone receptor-interacting protein 13 (human TRIP13), which is a transcription cofactor that binds the thyroid hormone receptor ATP binding protein F10B5.6 emb-27;cdc16;APC6;F10B5.6 Predicted component of the anaphase-promoting complex or cyclosome (APC/C), required for separation of homologous chromosomes during meiosis I cell division control protein; emb-27 encodes a tetratricopeptide repeat (TPR)-containing protein that is the C. elegans ortholog of the anaphase-promoting complex (APC) subunit APC-6 (CDC16); required maternally and paternally, EMB-27 activity is essential for proper execution of the metaphase-to-anaphase transition during meiosis (both oogenesis and spermatogenesis) and mitosis (during germline proliferation); EMB-27 activity is also critical for embryonic anterior-posterior (A-P) axis formation, production of the secreted eggshell, and normal vulval development; in establishing the embryonic A-P axis, EMB-27 likely acts upstream of the separin protease to ensure proper localization of PAR-3 and PAR-2 to the anterior and posterior cortices, respectively. F10B5.7 rrf-3;F10B5.7 Protein of unknown function, has a region of low similarity to C. elegans EGO-1, which is necessary for germ-line development rrf-3 encodes an RNA-directed RNA polymerase (RdRP) homolog that inhibits somatic RNAi, and thus promotes activity of repeated genes (e.g., multicopy transgenic arrays); the effect of RRF-3 on RNAi is opposite to that of RRF-1 (which stimulates somatic RNAi), which might arise from competition by RRF-3 with RRF-1 or EGO-1 in RNAi formation; rrf-3(allele) or rrf-3(allele2) mutants are hypersensitive to somatic RNAi, and conversely suppress the activity of an integrated rol6 (su1006) transgene. F10B5.8 F10B5.8 Putative ortholog of D. melanogaster CG1972 (CG1972 gene product) F10C1.1 F10C1.1 Protein of unknown function F10C1.2 ifb-1;F10C1.2 Member of the intermediate filament family, which are components of the cytoskeleton and nuclear envelope, contains an intermediate filament tail domain, has low similarity to lamin A (human LMNA), which is associated with muscular and lipodystrophies Intermediate filament protein; ifb-1 (also known as vab-21) encodes two isoforms of an essential intermediate filament protein that is coexpressed with the essential IF proteins IFA-1, IFA-2, and IFA-3, along with IFA-4; IFB-1 is required for embryonic development and epidermal morphogenesis; IFB-1 forms heteropolymeric intermediate filaments in vitro with an equimolar mixture of IFA-1, IFA-2, or IFA-3, and binds IFA-4 in blot overlay assays; IFB-1 resides in attachment structures of epidermal cells, found in sites undergoing mechanical stress; the two isoforms are expressed in different tissues and have distinct functions, since ifb-1A(RNAi) larvae have detached muscle cells, while ifb-1B(RNAi) larvae have detached cuticle. F10C1.3 F10C1.3 Protein of unknown function F10C1.5 F10C1.5 Protein containing two DM (dsx and mab-3) DNA binding domains, has a region of high similarity to a region of C. elegans MAB-3, which is required for sex-specific production of yolk proteins and male tail development D. melanogaster doublesex protein F10C1.7 ifb-2;F10C1.7 Member of the intermediate filament family, which are components of the cytoskeleton and nuclear envelope, contains three intermediate filament tail domains, has high similarity to uncharacterized C. elegans CEL-IF-B1 Intermediate filament protein; ifb-2 encodes a nonessential intermediate filament protein; IFB-2 is predicted to function as a structural component of the cytoskeleton; IFB-2 has no obvious function in RNAi assays. F10C2.2 kup-1;kup1;F10C2.2 Protein of unknown function KUP-1 protein; kup-1 encodes a novel protein that is conserved in C. briggsae, but contains no other known homologs; kup-1 is the upstream gene in an operon with pkc-1, which encodes two protein kinase C isoforms of the nPKC isotype; the polycistronic kup-1/pkc-1 mRNA is detected at low levels in embryos and larvae, but its expression greatly increases in adults; as loss of kup-1 activity via large-scale RNAi screens does not result in any obvious abnormalities, the precise role of kup-1 in C. elegans development and/or behavior is not yet known. F10C2.3 F10C2.3 Member of uncharacterized DUF229 family, has low similarity to uncharacterized C. elegans F15H10.7 F10C2.4 F10C2.4 Protein with high similarity to rat Pold1, which is the catalytic subunit of DNA polymerase delta 1 and has an essential role in DNA replication, member of the DNA-directed DNA polymerase B family, contains a DNA polymerase B exonuclease domain DNA polymerase family B; F10C2.4 encodes a homolog of the DNA polymerase delta complex subunit A that is required in embryos for the normal timing of embryonic cell divisions (much as DIV-1 is) and, also, for normal chromosome segregation (probably because of defective DNA replication). F10C2.5 F10C2.5 Member of the glycosyl hydrolase 47 family of alpha-mannosidases, which hydrolyze terminal mannose residues, has a region of low similarity to a region of S. cerevisiae Mnl1p, which is involved in endoplasmic reticulum-associated glycoprotein degradation mannosyl-oligosaccharide alpha-1,2-mannosidase F10C2.6 F10C2.6 Protein containing two class II asparagine, aspartic acid and lysine tRNA synthetase (D, K and N) domains, has a region of low similarity to a region of aspartyl-tRNA synthetase (human DARS), which aminoacylates tRNA with aspartate for protein synthesis aspartyl-tRNA synthetase; drs-2 encodes a putative aspartyl-tRNA synthetase. F10C2.7 F10C2.7 Protein with similarity to human and D. melanogaster sodium-dependent inorganic phosphate cotransporters F10C5.1 mat-3;apc-8;cdc-23;F10C5.1 Predicted component of the anaphase-promoting complex or cyclosome (APC/C), required for separation of homologous chromosomes during meiosis I (610391) x F10C5.2 F10C5.2 Protein of unknown function F10D11.1 sod-2;F10D11.1 Manganese superoxide dismutase superoxide dismutase; sod-2 encodes a iron/manganese superoxide dismutase, predicted to be mitochondrial, that might defend against oxidative stress and promote normal lifespan; sod-2 mRNA levels are diminished by mutation of daf-16, and heterologously expressed SOD-2 in E. coli protects against methyl viologen-induced oxidative stress. F10D11.2 F10D11.2 Protein of unknown function F10D11.3 F10D11.3 Protein of unknown function F10D11.4 F10D11.4 Protein of unknown function, has high similarity to uncharacterized C. elegans T15H9.5 F10D11.5 F10D11.5 Protein of unknown function, has moderate similarity to uncharacterized C. elegans T15H9.4 F10D11.6 F10D11.6 Protein containing lipopolysaccharide-binding protein, bactericidal permeability-increasing protein, or cholesteryl ester transfer protein N-terminal and C-terminal domains, has weak similarity to uncharacterized C. elegans F44A2.3 F10D2.1 F10D2.1 Member of the 7-transmembrane chemoreceptor family of G protein-coupled receptors (GPCR), has low similarity to C. elegans ODR-10, which is a G protein-coupled receptor involved in odorant response 7TM chemoreceptor, str family F10D2.10 F10D2.10 Protein of unknown function, has high similarity to uncharacterized C. elegans Y73C8B.3 F10D2.11 F10D2.11 Protein containing two UDP-glucoronosyl and UDP-glucosyl transferase domains, has low similarity to UDP-glucuronosyltransferase 1 A7 (rat Ugt1a7), which converts hydrophobic xenobiotic and endobiotic compounds to hydrophilic compounds glucuronosyltransferase F10D2.2 F10D2.2 Protein containing a UDP-glucoronosyl and UDP-glucosyl transferase domain, has low similarity to UDP glycosyltransferase 2 polypeptide B10 (human UGT2B10), which is a UDP-glucuronosyltransferase for which no substrate has been found glucuronosyltransferase F10D2.3 F10D2.3 Member of the C. elegans Sre G protein-coupled chemoreceptor family, which are putative chemosensory receptors, has moderate similarity to uncharacterized C. elegans T07H8.7 F10D2.4 F10D2.4 Protein with high similarity to C. elegans ODR-10, which is a G protein-coupled receptor involved in odorant response, member of the 7-transmembrane chemoreceptor family of G protein-coupled receptors (GPCR) 7TM chemoreceptor, str family F10D2.5 F10D2.5 Protein containing two UDP-glucoronosyl and UDP-glucosyl transferase domains, has low similarity to UDP-glucuronosyltransferase 8 (UDP-galactose ceramide galactosyltransferase, rat Ugt8), which acts in the formation of galactosylceramide glucuronosyltransferase F10D2.6 F10D2.6 Protein containing two UDP-glucoronosyl and UDP-glucosyl transferase domains, has weak similarity to UDP glycosyltransferase 1 family polypeptide A6 (mouse Ugt1a6), which catalyzes the glucoronidation of small planar phenolic molecules glucuronosyltransferase F10D2.7 F10D2.7 Protein containing a UDP-glucoronosyl and UDP-glucosyl transferase domain, has low similarity to UDP-glucuronosyltransferase 2B family member 5 (mouse Ugt2b5), which conjugates lipophilic aglycon substrates with glucuronic acid glucuronosyltransferase F10D2.8 F10D2.8 Protein containing a UDP-glucoronosyl and UDP-glucosyl transferase domain, has low similarity to UDP glycosyltransferase 1 family polypeptide A1 (human UGT1A), which acts in bilirubin conjugation and plays a role in Gilbert and Crigler-Najjar syndromes F10D2.9 fat-7;F10D2.9 Likely a stearoyl-CoA delta-9 fatty acid desaturase, specific for long chain (16:0 - 18:0) fatty acids stearoyl-CoA desaturase; fat-7 encodes an essential delta-9 fatty acid desaturase that is required for the synthesis of monounsaturated fatty acids; fat-7 can substitute for the functions of the other two fatty acid desaturases, fat-5 and fat-6; RNA interference has shown that fat-7 is required for viability and normal growth. F10D7.1 F10D7.1 G protein-coupled receptor with similarity to human bombesin-like receptor F10D7.2 F10D7.2 Member of the sugar (and other) transporter family, has moderate similarity to uncharacterized tetracycline transporter-like protein (human TETRAN), which may be involved in tetracycline transport calcium alpha subunit; tetracycline resistance; This gene encodes a protein predicted by Eisenberg and coworkers, with 52% accuracy, to be mitochondrial. F10D7.3 F10D7.3 Protein containing a glutaredoxin domain, has a region of low similarity to a region of glutaredoxin 2 (human GLRX2), which is a glutaredoxin that reduces GSH based mixed disulfides and acts as an electron carrier glutaredoxin; This gene encodes a protein predicted by Eisenberg and coworkers, with 68% accuracy, to be mitochondrial. F10D7.4 F10D7.4 Protein of unknown function F10D7.5 F10D7.5 Protein containing three C3HC4 type (RING) zinc fingers, which may mediate protein-protein interactions, has low similarity to neuralized like (mouse Neurl), which is required for olfactory stimuli discrimination, locomotion and spermatid maturation D. melanogaster finger protein neuralized F10E7.1 F10E7.1 Protein of unknown function, has a region of low similarity to a region of C. elegans PHA-1, which is involved in pharyngeal development F10E7.10 F10E7.10 Protein of unknown function, has a region of low similarity to a region of C. elegans CUT-1, which is a cuticulin component F10E7.11 F10E7.11 Protein containing one Myb-like DNA-binding domain and one Egl-27 and MTA1 homology 2 (ELM2) domain, which may be involved in DNA or protein-protein binding, has high similarity to uncharacterized C. elegans T07F8.4 F10E7.2 F10E7.2 Protein of unknown function F10E7.3 F10E7.3 Protein with strong similarity to C. elegans C27H5.4 gene product F10E7.4 F10E7.4 Protein containing five type 1 thrombospondin domains, a kunitz or bovine pancreatic trypsin inhibitor domain and a reeler domain, has low similarity to F-spondin (rat Sponf), which is a cell adhesion molecules that promotes neurite extension F-spondin F10E7.5 F10E7.5 Protein with high similarity to 60S acidic ribosomal protein PO (human RPLP0L), which is a protein of the 60S large ribosomal subunit that may be involved in protein biosynthesis, apoptosis, and neuron differentiation, member of the ribosomal L10 family F10E7.6 F10E7.6 Protein of unknown function F10E7.7 F10E7.7 Protein with high similarity to ribosomal protein L35a (rat Rpl35a), which is a component of the 60S ribosomal subunit that binds RNA, member of the ribosomal L35Ae family 60s ribosomal protein L35A; rpl-33 encodes a large ribosomal subunit L35a protein. F10E7.8 F10E7.8 Protein of unknown function, has moderate similarity to uncharacterized human KIAA1170 F10E7.9 F10E7.9 Protein with strong similarity to a region of human and C. elegans sodium/potassium/chloride transporters bumetanide-sensitive Na-K-Cl cotransporter F10E9.1 F10E9.1 Protein of unknown function F10E9.10 F10E9.10 Protein of unknown function F10E9.11 F10E9.11 Protein of unknown function F10E9.12 F10E9.12 Protein of unknown function F10E9.2 F10E9.2 Protein of unknown function, has similarity to C. elegans Y38H8A.2 F10E9.3 F10E9.3 Protein of unknown function F10E9.4 F10E9.4 Protein of unknown function F10E9.5 F10E9.5 Protein of unknown function F10E9.6 mig-10;F10E9.6 Protein containing two pleckstrin homology (PH) domains, which mediate protein-protein and protein-lipid interactions, has low similarity to mouse Apbb1ip, which is a proline-rich protein that interacts with the neural-specific protein mouse FE65 mig-10 encodes a protein containing a pleckstrin homology domain and a proline-rich region, and is similar to the SH2-domain containing adapter proteins Grb7 and Grb10 which are involved in receptor tyrosine kinase-mediated signal transduction; MIG-10 is likely required for signal transduction during cell migration, as it is required non-cell autonomously for excretory canal development and anterior-posterior migrations of the embryonic neurons ALM, CAN, and HSN; mig-10 mutations appear to interact genetically with mutations in all three C. elegans rac genes, ced-10, mig-2, and rac-2, suggesting partial redundancy during neuronal migration and excretory canal outgrowth; MIG-10 is expressed in many embryonic cells and in four cells in the adult head. F10E9.7 F10E9.7 Protein containing a cytidine deaminase zinc-binding domain F10E9.8 F10E9.8 Putative coiled-coil protein, has weak similarity across the C-terminus to human CENPF ( centromere protein F) sas-4 encodes a predicted coiled-coil protein and centriole component recruited to the centrosome once per cell cycle at the time of organelle duplication and is required for centriole duplication and spindle assembly, levels dictate centrosome size, and also affects germ cell proliferation and locomotion; colocalizes with gamma-tubulin to centrosomes both in sperm and in the syncitial part of the gonad. F10F2.1 F10F2.1 Protein containing five WD domains (WD-40 repeat), which may mediate protein-protein interactions, and a beige or BEACH domain, has moderate similarity to neurobeachin (mouse Nbea), which binds to and recruits protein kinase A (PKA) to membranes WD domain, G-beta repeat (2 domains) F10F2.2 F10F2.2 Protein with high similarity to phosphoribosylformylglycinamide amidotransferase (human PFAS), which catalyzes the fourth reaction in de novo purine synthesis, contains two AIR synthase-related protein C-terminal and one AIR synthase N-terminal domains Phosphoribosylformylglycinamidine synthase F10F2.3 F10F2.3 Member of the class 2 lipase family, has moderate similarity to uncharacterized C. elegans T01C3.4 lipase (Bacillus subtilis) F10F2.4 F10F2.4 Protein containing nine leucine rich repeats, which mediate protein-protein interactions, and a leucine rich repeat C-terminal cysteine rich domain, has low similarity to uncharacterized glycoprotein A repetitions predominant (human GARP) 2 leucine rich domains F10F2.5 F10F2.5 Member of the C-type lectin family, has weak similarity to human versican chondroitin sulfate proteoglycan C-lectin binding domain F10F2.6 F10F2.6 Member of the C-type lectin family, has weak similarity to human versican chondroitin sulfate proteoglycan and human lymphocyte antigen LY75 C-lectin binding domain F10F2.7 F10F2.7 Member of the C-type lectin family, has weak similarity to human lymphocyte antigen 75 (LY75), has weak similarity to versican, aggrecan, and neurocan chondroitin sulfate proteoglycans C-lectin binding domain F10F2.8 F10F2.8 Member of the C-type lectin family, has weak similarity to human versican and aggrecan chondroitin sulfate proteoglycans C-lectin binding domain F10F2.9 F10F2.9 Protein with weak similarity to C. elegans Y113G7B.12 gene product The protein product of this gene is predicted to contain a glutamine/asparagine (Q/N)-rich ('prion') domain, by the algorithm of Michelitsch and Weissman (as of the WS77 release of WormBase, i.e., in wormpep77). F10G2.1 F10G2.1 Protein containing one DUF19 domain of unknown function, which contain twelve conserved cysteines, has high similarity to uncharacterized C. elegans F07B7.13 F10G2.2 F10G2.2 Protein of unknown function, has similarity to an uncharacterized C. elegans protein family including F58E6.4 F10G2.3 F10G2.3 Member of the C-type lectin protein family F10G2.4 F10G2.4 Protein of unknown function F10G2.6 F10G2.6 Protein of unknown function, has high similarity to uncharacterized C. elegans H12C20.5 7TM chemoreceptor, srx family F10G2.7 F10G2.7 Protein of unknown function, has moderate similarity to uncharacterized C. elegans F36D3.8 F10G2.8 F10G2.8 Member of the 7-transmembrane chemoreceptor family of G protein-coupled receptors (GPCR), has high similarity to uncharacterized C. elegans C03G6.20 7TM chemoreceptor, srh family F10G2.9 F10G2.9 Protein containing a nuclear hormone receptor ligand-binding domain and a nuclear hormone receptor C4-type zinc finger domain, which bind DNA and may be involved in regulation of transcription zinc finger protein F10G7.1 F10G7.1 Putative ortholog of S. cerevisiae Ydl060p, a protein of unknown function F10G7.10 F10G7.10 Member of the transthyretin-like family, contains a putative zinc finger in N-recognin domain F10G7.2 F10G7.2 Protein with high similarity to EBNA-2 co-activator (human p100), which is a gene expression coactivator that may bind single-stranded DNA and is required for normal cell growth, member of the staphylococcal nuclease family, contains a tudor domain human 100 kDa activator protein F10G7.3 F10G7.3 Protein with moderate similarity to S. cerevisiae Asf1p, which is a component of replication-coupling chromatin assembly factor (RCAF) and a target of the Rad53p-dependent DNA damage response F10G7.4 coh-2;F10G7.4 Sister chromatid cohesion protein, believed to function in a double strand break DNA repair pathway DNA double-strand break repair; scc-1 encodes a member of the Rad21/Rec8-like family of cohesion proteins that affects embryonic viability, fertility, the rate of embryonic cell divisions and the incidence of male progeny; interacts with ATL-1, F56D12.5, and F11E6.1 based on yeast two-hybrid assays, and is expressed in nondividing embryonic and germline nuclei. F10G7.5 F10G7.5 Protein of unknown function, has low similarity to uncharacterized C. elegans Y59A8B.21 F10G7.6 F10G7.6 Putative ortholog of C. elegans W03B1.5 gene product F10G7.7 F10G7.7 Member of the C. elegans Sre G protein-coupled chemoreceptor family, which are putative chemosensory receptors F10G7.8 rpn-5;F10G7.8 Putative non-ATPase subunit of 19S particle of the 26S proteasome complex F10G7.9 F10G7.9 Protein with moderate similarity to C. elegans C01G5.3 gene product F10G8.2 F10G8.2 Protein with moderate similarity to C. elegans T09B4.7 gene product Eukaryotic protein kinase domain F10G8.3 F10G8.3 Protein with high similarity to RNA export 1 homolog (human RAE1), which is an RNA-binding protein that may function in the nuclear export of mRNA, contains five WD domains (WD-40 repeat), which may mediate protein-protein interactions polyA RNA export protein F10G8.4 F10G8.4 Member of the protein-tyrosine phosphatase family, which are involved in control of cell growth, proliferation, differentiation and transformation, has low similarity to a region of protein tyrosine phosphatase (receptor-type, kappa) (human PTPRK) protein-tyrosine phosphatase F10G8.5 ncs-2;Ce-ncs-2;F10G8.5 Protein that inhibits rhodopsin phosphorylation in a calcium-dependent manner NCS-2 neuronal calcium sensor protein F10G8.6 F10G8.6 Member of the nucleotide binding protein family nucleotide binding protein; This gene encodes a protein predicted by Eisenberg and coworkers, with 52% accuracy, to be mitochondrial. F10G8.7 F10G8.7 Protein with low similarity to excision repair cross complementing 1 (mouse Ercc1), which is an endonuclease which forms a complex with XPF (ERCC4) to function in nucleotide excision and DNA crosslink repair and is essential for viability DNA excision repair protein F10G8.8 F10G8.8 Coiled-coil protein containing two PH (pleckstrin homology) domains (commonly found in signaling proteins) PH (pleckstrin homology) domain (2 domains) F10G8.9 F10G8.9 Protein containing one beta-ketoacyl synthase N-terminal domain, which are involved in dimer formation and one beta-ketoacyl synthase C-terminal domain, has moderate similarity to S. cerevisiae Cem1p, which is a mitochondrial beta-ketoacyl-ACP synthase beta-ketoacyl synthase; This gene encodes a protein predicted by Eisenberg and coworkers, with 68% accuracy, to be mitochondrial. F11A1.2 F11A1.2 Protein of unknown function F11A1.3 daf-12;daf-20;mig-7;F11A1.3 Protein similar to nuclear hormone receptors; required for progression from the L2d pre-dauer larval stage to the normal dauer larval stage; involved in heterochronic life stage transitions daf-12 encodes a member of the steroid hormone receptor superfamily that affects dauer formation downstream of the TGF- and insulin signaling pathways, and affects gonad-dependent adult longevity together with DAF-16, chemosensory signal transduction, and distal tip cell migration and hypodermal and intestinal cell lineages during the L3 larval stage; expressed in the nucleus and in most cells; DAF-12 is homologous to human VITAMIN D RECEPTOR (VDR; OMIM:601769, mutated in vitamin D-resistant rickets. F11A10.1 F11A10.1 Putative ATPase of the AAA family of ATPases TAT-binding homolog like F11A10.2 F11A10.2 Protein with low similarity to S. cerevisiae Prp11p, which is a pre-mRNA splicing factor that is associated with U2, U4, U5, and U6 snRNPs F11A10.3 F11A10.3 Protein containing five CCCH-type zinc finger domains, a zinc knuckle domain, and a C3HC4 type (RING) zinc finger, has a region of high similarity to a region of cleavage and polyadenylation specific factor 4 30 kDa subunit (human CPSF4) Zinc finger, C3HC4 type (RING finger) F11A10.4 F11A10.4 Protein of unknown function F11A10.5 F11A10.5 Protein of unknown function, has high similarity to uncharacterized human ST7 F11A10.6 F11A10.6 Protein with moderate similarity to D. melanogaster CG9536 (CG9536 gene product) F11A10.7 F11A10.7 Protein with weak similarity to C. elegans sap-49 gene product F11A3.1 F11A3.1 Member of the AMP-binding enzyme family, has weak similarity to C. albicans Acs1p, which is an acetyl-coenzyme A synthetase (acetate-coA ligase) 4-coumarate-CoA ligase F11A3.2 F11A3.2 Member of the initiation factor 2 subunit family, has weak similarity to eukaryotic translation initiation factor 2B delta subunit (rat Eif2b), which is a component of the guanine nucleotide-exchange factor for eukaryotic initiation factor eIF-2B guanine nucleotide exchange factor F11A5.1 F11A5.1 Member of the 7-transmembrane chemoreceptor family of G protein-coupled receptors (GPCR), has high similarity to uncharacterized C. elegans F11A5.2 F11A5.10 glc-1;F11A5.10 Avermectin-sensitive glutamate-gated chloride channel GluCl-alpha subunit ligand-gated ion channel; glc-1 encodes the alpha subunit of a glutamate-gated chloride channel and forms a functional channel in Xenopus oocytes; mutations genetically interact with avr-14 and avr-15 mutations such that triple mutants exhibit high level resistance to ivermectin. F11A5.11 F11A5.11 Member of the 7-transmembrane chemoreceptor family of G protein-coupled receptors (GPCR), has moderate similarity to uncharacterized C. elegans SRI-36 F11A5.12 F11A5.12 Member of the short-chain dehydrogenase-reductase family, which are NAD- or NADP-dependent oxidoreductases, has moderate similarity to rat Hsd17b3, which is a type III hydroxysteroid 17-beta dehydrogenase that converts androstenedione to testosterone Estradiol 17-beta-dehydrogenase; This gene encodes a protein predicted by Eisenberg and coworkers, with 68% accuracy, to be mitochondrial. F11A5.13 F11A5.13 Protein of unknown function F11A5.2 F11A5.2 Member of the 7-transmembrane chemoreceptor family of G protein-coupled receptors (GPCR), has high similarity to uncharacterized C. elegans F11A5.1 F11A5.3 F11A5.3 Protein with high similarity to ras-related GTP-binding protein 2 (human RAB2), which is a GTPase that plays a role in vesicle transport from the ER to the Golgi and is associated with Searzy syndrome, member of the Ras superfamily of GTP-binding proteins RAS related protein F11A5.4 F11A5.4 Protein with high similarity to ras-related GTP-binding protein 2 (human RAB2), which is a GTPase that plays a role in vesicle transport from the ER to the Golgi and is associated with Searzy syndrome, member of the Ras superfamily of GTP-binding proteins RAS related protein F11A5.5 F11A5.5 Member of the glycosyl transferase family 11, which hydrolyze the glycosidic bond between two or more carbohydrates, has high similarity to uncharacterized C. elegans K06H6.6 F11A5.6 F11A5.6 Protein with moderate similarity to C. elegans C18A11.6 gene product F11A5.7 F11A5.7 Protein containing one DUF41 domain of unknown function, has high similarity to uncharacterized C. elegans Y73F8A.18 F11A5.8 F11A5.8 Protein containing one DUF33 domain of unknown function, has high similarity to uncharacterized C. elegans B0399.2 F11A5.9 F11A5.9 Member of the sugar (and other) transporter family, has weak similarity to brain-specific Na+-dependent inorganic phosphate cotransporter (rat BNPI), which is a vesicular glutamate transporter that has a presynaptic role in glutamatergic neurotransmission sodium/phosphate transporter F11A6.1 kpc-1;CelfurPC;F11A6.1 Putative furin endoprotease, predicted to cleave preproteins near pairs of basic residues Furin like serine protease; kpc-1 encodes two isoforms of a Kex2/subtilisin-like proprotein convertase that is a member of the subtilase family of calcium-dependent serine endoproteinases that includes mammalian furin (OMIM:136950) and Saccharomyces cerevisiae Kex2p; KPC-1 is required for normal growth and locomotion and is likely responsible for the processing of transforming growth factor (TGF) beta proproteins encoded by daf-7, dbl-1, and unc-129. F11A6.2 F11A6.2 Protein with low similarity to plasma membrane phospholipid scramblase 1 (human PLSCR1), which mediates Ca2+-dependent movement of membrane phospholipids in activated, injured, or apoptotic cells and is a substrate of tyrosine kinase c-Abl F11A6.2 encodes a homolog of human scramblase (PLSCR1; OMIM:604170), which is activated by a rise of intracellular calcium, and which promotes the exposure of phosphatidylserine on the surface of cells undergoing activation, injury, or apoptosis; paralogs of F11A6.2 include C04E12.7, T22H2.5, ZK1053.5. F11C1.1 F11C1.1 Protein of unknown function, has high similarity to uncharacterized C. elegans F42H10.2 F11C1.2 F11C1.2 Protein of unknown function, has similarity to C. elegans F55F8.6 F11C1.3 F11C1.3 Member of the CD36 family of putative scavenger receptors, has low similarity to scavenger receptor BI (mouse Srb1), which mediates the selective uptake of cholesterol from high and low density lipoproteins and activates endothelial nitric oxide membrane glycoprotein F11C1.4 F11C1.4 Protein with strong similarity to C. elegans F26A3.1 gene product F11C1.5 F11C1.5 Protein of unknown function, has moderate similarity to uncharacterized human KIAA0564 nir like gene involved in denitrification F11C1.6 nhr-25;F11C1.6 Member of FTZ-F1 family of nuclear receptors and essential for embryogenesis nuclear hormone receptor; nhr-25 encodes a nuclear hormone receptor orthologous to Drosophila Ftz-F1; NHR-25 is required for embryogenesis, molting, vulval and gonadal development, and hypodermal expression of acn-1; nhr-25 is expressed in gonads and loaded into embryos as a maternal transcript; nhr-25 is zygotically expressed in progeny of the E cell, and then in hypodermis and gut; the role of NHR-25 in molting may be evolutionarily conserved between nematodes and arthopods. F11C3.1 F11C3.1 Protein with strong similarity to C. elegans F59H6.5 gene product F11C3.2 unc-122;F11C3.2 Olfactomedin homolog involved in the sprouting of the C. elegans DVB neuron; mutations lead to a defect in cholinergic synaptic transmission unc-122 encodes a predicted type II transmembrane protein with extracellular collagen-like domains and a highly conserved olfactomedin (OLF) domain that is found in a family of secreted proteins involved in formation and function of nervous systems; UNC-122 is required for proper locomotion and for normal morphology of the DVB motorneuron, and may regulate neuromuscular function by acting in an aminergic/peptidergic pathway parallel to cholinergic neurotransmission; although mosaic analysis indicates that UNC-122 activity is required in muscle cells, the precise expression and localization patterns of UNC-122 are not yet known. F11C3.3 unc-54;mhc-b;myo-b;myo-4;Myosin-B;Band-2-myosin;F11C3.3 Sarcomeric Myosin Heavy Chain, major component of thick filaments in body-wall muscle myosin heavy chain; unc-54 encodes a muscle myosin class II heavy chain (MHC B); UNC-54 is the major myosin heavy chain expressed in C. elegans and is required for locomotion and egg-laying; in vivo and in vitro, UNC-54 interacts with ITR-1, an IP3 receptor, and this interaction may provide a link between calcium signaling and the muscle cytoskeleton; UNC-54 is a thick filament component that is expressed in multiple muscle cell classes including body wall, intestinal, anal depressor, and sphincter muscles as well as sex-specific muscles that develop postembryonically. F11C7.1 F11C7.1 Protein containing a neurotransmitter-gated ion-channel ligand binding domain, has low similarity to a region of C. elegans DEG-3, which is a subunit of the nicotinic acetylcholine receptor that is associated with neuronal degeneration ligand-gated ionic channel F11C7.2 F11C7.2 Protein containing a type 1 thrombospondin domain, has a region of low similarity to a region of semaphorin 5B (semaphorin G, mouse Sema5b), which is involved in embryogenesis and morphogenesis F11C7.3 vap-1;F11C7.3 Member of the SCP-like extracellular protein family, has a region of low similarity to a region of specific granule protein 28kDa (human SGP28), which is a glycoprotein that is widely expressed and localizes to specific granules in neutrophils F11C7.4 crb-1;F11C7.4 Notch family member; has strong similarity to D. melanogaster crb (crumbs) protein which is involved in cell polarity EGF-like repeats; crb-1 encodes a homolog of Drosophila CRUMBS that affects dauer formation and feeding behavior; CRB-1 can bind cyclic AMP-response element (CRE) sites and be phosphorylated by PKA in vitro, and is expressed immediately apical to the zonula adherens in embryos and then ubiquitously later during development and in adults; CRB-1 is homologous to human CRB1 (OMIM:604210, mutated in retinitis pigmentosa 12 or Leber congenital amaurosis). F11C7.5 F11C7.5 Protein of unknown function, has weak similarity to C. elegans T05D4.4 F11D11.1 F11D11.1 Protein containing a C-type lectin domain, which mediate calcium-dependent carbohydrate recognition, has moderate similarity to uncharacterized C. elegans Y17D7B.6 F11D11.10 F11D11.10 Protein with moderate similarity to C. elegans Y22D7AL.2 gene product F11D11.2 F11D11.2 Protein with strong similarity to C. elegans T20H12.2, which is a transposase, member of the transposase family, which are required for excising and inserting mobile genetic elements F11D11.3 F11D11.3 Protein of unknown function, has moderate similarity to uncharacterized C. elegans ZK6.10 F11D11.4 F11D11.4 Putative ortholog of C. elegans F11D11.3 gene product F11D11.5 F11D11.5 Protein containing a C-type lectin domain, which mediate calcium-dependent carbohydrate recognition, has high similarity to uncharacterized C. elegans F11D11.8 F11D11.6 F11D11.6 Protein containing a C-type lectin domain, which mediate calcium-dependent carbohydrate recognition, has low similarity to uncharacterized C. elegans Y17D7B.6 F11D11.7 F11D11.7 Protein of unknown function, has high similarity to uncharacterized C. elegans F11D11.5 F11D11.8 F11D11.8 Protein of unknown function, has high similarity to uncharacterized C. elegans F11D11.5 F11D11.9 F11D11.9 Member of the transposase family, which are required for excising and inserting mobile genetic elements, has very strong similarity to uncharacterized C. elegans Y95B8A.3 HYPOTHETICAL 29.3 KD PROTEIN B0280.6 IN CHROMOSOME III F11D5.1 F11D5.1 Putative ortholog of C. elegans ZK816.2 gene product F11D5.3 F11D5.3 Protein containing two F5 or 8 type C (discoidin) domains and two protein kinase domains, has low similarity to discoidin domain receptor 2 (human DDR2), which is a receptor protein tyrosine kinase that is activated by collagen tyrosine kinase; F11D5.3 encodes a putative tyrosine kinase homologous to human RS1 (OMIM:312700, mutated in juvenile X-linked retinoschisis). F11D5.4 F11D5.4 Protein of unknown function, has low similarity to uncharacterized C. elegans F11D5.5 F11D5.5 F11D5.5 Protein of unknown function, has high similarity to uncharacterized C. elegans K09C4.1 glucose transporter (weak) F11D5.6 F11D5.6 Protein of unknown function F11E6.1 F11E6.1 Putative ortholog of C. elegans F11E6.1 gene product glucosylceramidase (O-glycosyl hydrolase); F11E6.1 is homologous to to the human gene GLUCOCEREBROSIDASE (GBA; OMIM:606463), which when mutated leads to Gaucher disease. F11E6.2 F11E6.2 Protein of unknown function F11E6.3 F11E6.3 Protein of unknown function, has weak similarity to a region of heavy polypeptide of neurofilament (mouse Nfh), which is a cytoskeletal structural protein that may regulate axonal caliber, synaptic transmission, and type IV intermediate filament assembly F11E6.4 F11E6.4 Protein of unknown function F11E6.5 F11E6.5 Member of the GNS1 or SUR4 family of integral membrane proteins, has moderate similarity to polyunsaturated fatty acid (PUFA) elongase (C. elegans CEEl01), which contains the condensation activity required for fatty acid elongation GNS1/SUR4 family; The elo-2 gene encodes a palmitic acid elongase, homologous to polyunsaturated fatty acid (PUFA) elongases such as ELO-1, that is required for normally rapid growth, normally large body size, fertility, and for the quantitative regulation of the ultradian defecation rhythm; the joint action of ELO-2 with ELO-1 is strongly required for 20-carbon PUFA production and for general viability; elo-2 is most strongly expressed in intestinal cells, as well as other tissues such as the ventral nerve cord, pharyngeal muscles, uterus, and tail. F11E6.6 F11E6.6 Protein of unknown function F11E6.7 F11E6.7 Protein of unknown function, has high similarity to uncharacterized C. elegans F19H6.3 F11E6.8 F11E6.8 Protein containing a protein kinase domain, has low similarity to v-src avian sarcoma viral oncogene homolog (Schmidt-Ruppin A-2, human SRC), which is a tyrosine kinase involved in cell proliferation, cell adhesion, and cytoskeletal organization Eukaryotic protein kinase domain F11F1.1 F11F1.1 Member of the Hsp70 family, which are stress-induced protein chaperones, has moderate similarity to heat shock 70kD protein 8 (rat Hspa8), which is involved in protein folding, translocation, and assembly into complexes Heat shock hsp70 proteins F11F1.2 F11F1.2 Protein containing one DUF148 domain of unknown function, has strong similarity to uncharacterized C. elegans F11F1.5 F11F1.4 F11F1.4 Protein containing one DUF148 domain of unknown function, has strong similarity to uncharacterized C. elegans F11F1.2 F11F1.5 F11F1.5 Protein containing one DUF148 domain of unknown function, has strong similarity to uncharacterized C. elegans F11F1.2 F11F1.6 F11F1.6 Protein of unknown function F11F1.7 F11F1.7 Member of the transthyretin-like family Transthyretin-like family F11G11.1 F11G11.1 Protein containing glutathione S-transferase N-terminal and C-terminal domains, has low similarity to prostaglandin D2 synthase (human PGDS), which is a prostaglandin D synthase and glutathione S-transferase that regulates non-rapid eye movement sleep glutathione S-transferase; gst-8 encodes a predicted glutathione S-transferase. F11G11.10 col-17;F11G11.10 Protein of unknown function, has a region of low similarity to glutamine repeat protein 1 (mouse Glrp1), which is a putative transcription factor that may be involved in the immune response collagen; col-17 encodes a collagen which is expressed in all developmental stages except eggs, like col-15, col-16, and col-20; collagen genes with this expression pattern may be used for synthesis of cuticles after the L1 stage (e.g., the L4 cuticle). F11G11.11 col-20;F11G11.11 Putative collagen, has strong similarity to C. elegans COL-17 collagen collagen; col-20 encodes a collagen; its expression pattern and mutant phenotypes are unknown. F11G11.12 F11G11.12 Protein containing two collagen triple helix repeats, which are found in some extracellular proteins, and a nematode cuticle collagen N-terminal domain, has a region of moderate similarity to a region of type XI collagen alpha 2 subunit (human COL11A2) collagen F11G11.13 F11G11.13 Protein containing an ATP:guanido phosphotransferase C-terminal catalytic domain F11G11.2 F11G11.2 Protein containing glutathione S-transferase N-terminal and C-terminal domains, has low similarity to prostaglandin D2 synthase (human PGDS), which is a prostaglandin D synthase and glutathione S-transferase that regulates non-rapid eye movement sleep glutathione S-transferase; gst-7 encodes a predicted glutathione S-transferase. F11G11.3 F11G11.3 Protein containing glutathione S-transferase N-terminal and C-terminal domains, has low similarity to prostaglandin D2 synthase (human PGDS), which is a prostaglandin D synthase and glutathione S-transferase that regulates non-rapid eye movement sleep glutathione S-transferase; gst-6 encodes a predicted glutathione S-transferase. F11G11.4 F11G11.4 Protein of unknown function, has strong similarity to uncharacterized C. elegans C24D10.2 F11G11.5 F11G11.5 Protein of unknown function F11G11.6 F11G11.6 Protein of unknown function F11G11.7 F11G11.7 Protein containing one DnaJ domain, which are part of chaperone system that mediates interaction with heat shock proteins, has a region of high similarity to a region of dnaJ homolog subfamily B member 4 (human DNAJB4), which is a heat shock protein This gene encodes a protein containing a DnaJ ('J') domain. F11G11.8 F11G11.8 Protein of unknown function F11G11.9 F11G11.9 Protein containing a rhodanese-like domain, has weak similarity to thiosulfate sulfotransferase (rhodanese, human TST), which is a thiosulfate sulfotransferase enzyme that functions in the detoxification of cyanide F11H8.1 uba-3;F11H8.1 Protein with high similarity to ubiquitin-activating enzyme E1C (human UBE1C), which is a subunit of an E1-like complex, member of the UBA-THIF-type NAD-FAD binding fold family, contains a repeat in ubiquitin-activating (UBA) protein domain ubiquitin-activating enzyme; rfl-1 (also known as cyk-5) encodes an ortholog of UBA3, a Nedd8 activating enzyme for ubiquitin-like proteins, which is required for proper cytokinesis and spindle orientation; NED-8 is presumably activated by an ULA-1/RFL-1 heterodimer. F11H8.2 F11H8.2 Protein containing a neurotransmitter-gated ion-channel transmembrane and two ligand binding domains, has moderate similarity to C. elegans UNC-49 gamma-aminobutyric acid receptor F11H8.3 col-8;F11H8.3 Collagen of the collagen triple helix repeat (20 copies) family col-8 encodes a collagen, individually dispensable for viability and gross morphology, which is specifically expressed in dauers and adults but not in eggs or L4 larvae, like col-7, col-18, and col-19; the amino- and carboxyl-terminal cysteine-rich regions of COL-8 are most closely related to those of COL-19, COL-35, and COL-39. F11H8.4 cyk-1;F11H8.4 Formin homology (FH) family member required for completion of cytokinesis required for a late step in embryonic cytokinesis; The cyk-1 gene encodes a homolog of Drosophila diaphanous and human DIAPH1. F12A10.1 F12A10.1 Protein of unknown function F12A10.2 F12A10.2 Putative ortholog of C. elegans F59E12.6 gene product F12A10.3 F12A10.3 Protein containing three pyridoxal-dependent group II decarboxylase conserved domains, which bind pyridoxal-phosphate groups, has moderate similarity to dopa decarboxylase (aromatic L-amino acid decarboxylase, rat Ddc) aromatic-L-amino-acid decarboxylase F12A10.4 F12A10.4 Member of the M13 peptidase family of zinc metalloproteases, has weak similarity to mel transforming oncogene-like protein1 1 (mouse Mell1), which is a type II membrane bound metalloprotease that has a secreted alternative form Neprilysin; F12A10.4 encodes a neprilysin; neprilysins are thermolysin-like zinc metallopeptidases, found on the outer surface of animal cells, that negatively regulate small signalling peptides (e.g., enkephalin, tachykinin, insulin, and natriuretic peptides) by cleaving them; F12A10.4 has no clear orthologs in other organisms. F12A10.5 F12A10.5 Protein with high similarity to calmodulin 1 (human CALM1), which regulates the calcium-dependent activity of proteins and enzymes including ion channels, kinases, phosphatases, and phosphodiesterases, contains four EF hand domains Calmodulin F12A10.6 F12A10.6 Protein with moderate similarity to C. elegans ZK177.2 gene product F12A10.7 F12A10.7 Protein of unknown function F12A10.8 F12A10.8 Protein of unknown function F12B6.1 F12B6.1 Member of the ABC transporter family, has low similarity to ATP binding cassette subfamily A member 1 (human ABCA1), which mediates the transport of cholesterol, phospholipids and anions and plays a role in endocytosis abc transporter F12B6.2 F12B6.2 Member of the sugar (and other) transporter family, has weak similarity to C. elegans EAT-4, which is a putative Na+/Pi-cotransporter involved in muscle contraction, mechanosensory perception, synaptic transmission, and chemotaxis sodium dependent-phosphate transporter F12B6.3 F12B6.3 Protein containing two neurotransmitter-gated ion-channel ligand binding domains, has low similarity to the inhibitory glycine receptor alpha 3 subunit (rat Glra3), which may play a role in the modulation of neuronal differentiation and excitability ligand-gated ionic channel F12D9.1 F12D9.1 Protein of unknown function F12D9.2 F12D9.2 Protein of unknown function F12E12.1 F12E12.1 Putative ortholog of C. elegans F12E12.I gene product F12E12.3 F12E12.3 Putative ortholog of C. elegans F12E12.G gene product F12E12.4 F12E12.4 Putative ortholog of C. elegans F12E12.F gene product F12E12.7 F12E12.7 Putative ortholog of C. elegans F12E12.A gene product F12E12.D F12E12.6;F12E12.D Protein of unknown function F12E12.E F12E12.5;F12E12.E Protein with strong similarity to C. elegans C46E10.9 gene product F12E12.H F12E12.2;F12E12.H Protein of unknown function F12F3.1 exp-2;nShab3;F12F3.1 Inward rectifying pharyngeal K-type (voltage activated) potassium channel potassium channel protein F12F3.2 F12F3.2 Protein containing 4 fibronectin type III domains, 32 immunoglobulin (Ig) domains, and 2 protein kinase domains, has weak similarity to a region of titin (human TTN), which is a sarcomeric protein that maintains resting tension in muscle F12F3.3 F12F3.3 Putative member of the Immunoglobulin superfamily of muscle proteins F12F6.1 F12F6.1 Protein of unknown function F12F6.2 F12F6.2 Protein of unknown function F12F6.3 rib-1;F12F6.3 Protein of unknown function, has high similarity to a region of exostoses 1 (human EXT1), which forms a glycosyltransferase complex with EXT2 that catalyzes the polymerization of heparan sulfate glycosaminoglycans MULTIPLE EXOSTOSES HOMOLOG 1; The rib-1 gene encodes an ortholog of human EXT1, which when mutated leads to hereditary multiple exostoses, type I (OMIM:133700). F12F6.5 F12F6.5 Protein of unknown function, has similarity to human chimaerin chimaerin like F12F6.6 F12F6.6 Protein with moderate similarity to SEC24 (S. cerevisiae) related gene family member C (human SEC24C), which is a putative COPII vesicle coat protein that may function in cargo recruitment during ER-Golgi transport Yeast hypothetical YIK9 protein like; sec-24.1 encodes one of two C. elegans Sec24 homologs; in Saccharomyces cerevisiae, Sec24 is a member of the Sec24-Sec23 subunit of the COPII coat complex, assembly of which is essential for the first step of secretory protein transport from the endoplasmic reticulum (ER) to the Golgi; by homology with Sec24, SEC-24.1 is predicted to facilitate vesicle cargo selection, and likely contains multiple, independent sites for binding to secreted proteins; loss of sec-24.1 activity via RNAi indicates that SEC-24.1 is required for cuticle secretion and oogenesis. F12F6.7 F12F6.7 Protein with strong similarity to the small subunit of DNA polymerase delta Yeast HUS2 protein like F12F6.8 F12F6.8 Protein of unknown function, has weak similarity to zygote-defective 11 (C. elegans ZYG-11), which is required for zygote formation C.elegans ZYG-11 protein like F12F6.9 F12F6.9 Protein containing two collagen triple helix repeats and one nematode cuticle collagen N-terminal domain, has a region of moderate similarity to a region of the alpha 2 subunit of type XI collagen (human COL11A2), which is important in hearing collagen F13A2.1 F13A2.1 Protein of unknown function F13A2.2 F13A2.2 Protein of unknown function F13A2.3 F13A2.3 Protein of unknown function F13A2.4 F13A2.4 Protein of unknown function F13A2.5 F13A2.5 Protein of unknown function F13A2.6 F13A2.6 Protein with strong similarity to C. elegans Y73F8A.Y gene product F13A2.8 F13A2.8 Protein containing a nuclear hormone receptor ligand-binding domain and nuclear hormone receptor C4-type zinc finger domain, has low similarity to a region of retinoic acid receptor alpha (mouse Rara), which is a ligand activated transcriptional regulator zinc finger protein F13A7.1 F13A7.1 Protein containing a major sperm protein (MSP) domain, which are involved in sperm motility F13A7.10 F13A7.10 Protein containing glutathione S-transferase N-terminal and C-terminal domains, has moderate similarity to glutathione-S-transferase like (human GSTTLp28), which is a thiol transferase and a dehydroascorbate reductase that modulates ryanodine receptors glutathione S-transferase F13A7.11 F13A7.11 Protein of unknown function, has high similarity to uncharacterized C. elegans C06B3.6 F13A7.2 F13A7.2 Protein of unknown function, has high similarity to uncharacterized C. elegans H04J21.2 7TM receptor F13A7.3 F13A7.3 Protein with moderate similarity to C. elegans F13A7.4 gene product G-protein coupled receptor, srv family F13A7.4 F13A7.4 Protein with moderate similarity to C. elegans F13A7.3 gene product F13A7.6 F13A7.6 Member of the 7-transmembrane chemoreceptor family of G protein-coupled receptors (GPCR), has moderate similarity to uncharacterized C. elegans F13A7.8 F13A7.7 F13A7.7 Protein with strong similarity to C. elegans F22H10.4 gene product F13A7.8 F13A7.8 Member of the 7-transmembrane chemoreceptor family of G protein-coupled receptors (GPCR), has moderate similarity to uncharacterized C. elegans D2062.3 7TM chemoreceptor, sri family F13A7.9 F13A7.9 Member of the Skp1 family, which are required for targeted protein degradation during the cell cycle, has low similarity to S. cerevisiae Skp1p, which is a component of SCF complexes involved in protein degradation The skr-11 gene encodes a homolog of Skp1 in S. cerevisiae that has no known function in vivo, since skr-11(RNAi) animals are at least superficially normal. F13B10.1 CeSARM;F13B10.1 Protein containing two SAM (sterile alpha motif) domains, which may mediate protein-protein interactions, and two TIR (Toll-IL-1R) domains, which may mediate protein-protein interactions SAM domain (Sterile alpha motif); tir-1 encodes a protein that may be involved in apoptosis: from N- to C-terminus, it has three domains; the first two are sterile alpha motif (SAM) domains; the last is a Toll-interleukin 1 (IL1) receptor (TIR) domain. F13B10.2 rpl-3;F13B10.2 Member of the ribosomal L3 protein family 60S ribosomal protein L3; rpl-3 encodes a large ribosomal subunit L3 protein required in mass RNAi assays for embryonic and larval viability, fertility, and general health; the rpl-3 transcription unit has a nonsense transcript that is up-regulated in vivo by smg[-] mutations, indicating that rpl-3 is a natural substrate for SMG-mediated nonsense suppresssion; several other natural mRNA substrates of SMG suppression (e.g., rpl-7, rpl-10, rpl-12) have protein products that are involved in translation. F13B12.1 F13B12.1 Protein of unknown function, has low similarity to uncharacterized human FLJ10006 F13B12.2 F13B12.2 Member of the sugar (and other) transporter family, has low similarity to facilitative glucose transporter 2 (human SLC2A2), which is a low-affinity, high-capacity glucose transporter that is associated with Fanconi-Bickel syndrome glucose tranporter like F13B12.3 F13B12.3 Protein with moderate similarity to C. elegans W03B1.2 gene product F13B12.4 F13B12.4 Member of the pyridoxal phosphate dependent enzyme beta family, has high similarity to uncharacterized C. elegans F01D4.8 cysteine synthase like F13B12.5 ins-1;ILP1;F13B12.5 Member of the insulin, insulin-like growth factor (IGF) or relaxin family, which act as secreted regulatory peptide hormones ins-1 encodes an insulin-like peptide orthologous to human insulin (INS; OMIM:176730, mutated in hyperproinsulinemia and diabetes mellitus type II); INS-1 is one of 38 insulin-like peptides in C. elegans and when overexpressed can antagonize insulin-like signaling mediated by DAF-2/IR leading to arrest at the dauer larval stage; loss of INS-1, however, does not result in a dauer phenotype suggesting that INS-1 functions redundantly with other insulin-like peptides to regulate reproductive growth and lifespan; INS-1 is expressed in the amphid sensory neurons ASI and ASJ that regulate dauer arrest, the nerve ring, the intestine, vulval muscles, and other neurons. F13B12.6 F13B12.6 Protein of unknown function F13B6.1 F13B6.1 Protein with strong similarity to C. elegans F13B6.2 gene product F13B6.2 F13B6.2 Protein with strong similarity to C. elegans F13B6.1 gene product F13B6.3 F13B6.3 Protein with strong similarity to C. elegans nhr-1 gene product F13B9.1 F13B9.1 Putative ortholog of C. elegans ZK512.5 gene product F13B9.1 encodes two proteins by alternative splicing which contain both an immunoglobulin/MHC-like domain and a glutamine/asparagine-rich domain. F13B9.2 F13B9.2 Protein of unknown function, has weak similarity to C. elegans Y34B4A_3.C F13B9.5 ksr-1;sur-3;F13B9.4;F13B9.5 Raf-like serine/threonine protein kinase involved in larval and vulval development, has similarity to human and D. melanogaster KSR (kinase suppressor of ras) protein kinases F13B9.8 F13B9.8 Protein of unknown function, has moderate similarity to uncharacterized human LOC51024 F13C5.1 F13C5.1 Protein of unknown function F13C5.2 F13C5.2 Protein containing a bromodomain, which interact specifically with acetylated lysine, has a region of moderate similarity to a region of bromodomain-containing 2 (human BRD2), which is a protein kinase that may be associated with leukemias bromodomain-containing protein F13C5.3 F13C5.3 Protein of unknown function F13C5.4 F13C5.4 Protein of unknown function F13C5.5 F13C5.5 Protein of unknown function F13C5.6 F13C5.6 Putative ortholog of C. elegans F13C5.7 gene product gei-10 encodes a novel protein conserved with C. briggsae BP:CBP01944 that interacts with GEX-3 in yeast two-hybrid assays. F13D11.1 F13D11.1 Member of the histidine acid phosphatase family, which hydrolyze phosphate esters at low pH, has low similarity to rat Acp2, which is a tartrate-inhibitable lysosomal acid phosphatase histidine acid phosphatase family (weak) F13D11.2 hbl-1;F13D11.2 Protein involved in differentiation of several tissues including the hypodermis; has strong similarity to D. melanogaster hb gene product C2H2-type zinc finger; hbl-1 encodes a protein that contains nine putative zinc finger domains of the C2H2 type and affects embryonic viability, locomotion, egg laying, body morphology, and hypodermal differentiation; expressed in hypodermal precursor cells, neuronal precursor cells, and pharyngeal cells during embryogenesis and is primarily expressed in neurons during larval development. F13D11.3 F13D11.3 Protein containing a dual specificity phosphatase catalytic domain, has moderate similarity to human DUSP13, which is a dual specificity phosphatase that may play a role in regulation of meiosis and differentiation of testicular germ cells protein tyrosine-phosphatase family F13D11.4 F13D11.4 Protein with low similarity to S. cerevisiae Gre2p, which is involved in diamide tolerance and is induced by osmotic stress dihydroflavonol-4-reductase (maize, petunia, tomato) F13D12.2 ldh-1;LDH;ldh;F13D12.2 Lactate dehydrogenase L-lactate dehydrogenase; ldh-1 is orthologous to the human gene LACTATE DEHYDROGENASE B (LDHB; OMIM:150100), which when mutated leads to lactate dehydrogenase-B deficiency. F13D12.3 F13D12.3 Protein of unknown function F13D12.4 F13D12.4 Protein with high similarity to methylmalonate-semialdehyde dehydrogenase (rat Mmsdh), which is involved in valine and pyrimide catabolism, member of the aldehyde dehydrogenase family, which use NADP as a cofactor methylmalonate-semialdehyde dehydrogenase; alh-8 is orthologous to the human gene METHYLMALONATE-SEMIALDEHYDE DEHYDROGENASE (ALDH6A1; OMIM:603178), which when mutated leads to MMSDH deficiency. F13D12.5 F13D12.5 Protein of unknown function, has moderate similarity to uncharacterized C. elegans T21B10.4 F13D12.6 F13D12.6 Member of the serine carboxypeptidase family, has moderate similarity to cathepsin A (protective protein for beta-galactosidase, human PPGB), which has carboxypeptidase activity and binds human GLB1 and human NEU1 and is associated with galactosialidosis serine carboxypeptidase; F13D12.6 is orthologous to the human gene SIMILAR TO PROTECTIVE PROTEIN FOR BETA-GALACTOSIDASE (GALACTOSIALIDOSIS) (PPGB; OMIM:256540), which when mutated leads to disease. F13D12.7 gpb-1;F13D12.7 Trimeric G protein beta-subunit that appears to act in the regulation of egg-laying and motility, member of the WD repeat family guanine nucleotide-binding protein beta subunit; gpb-1 encodes a heterotrimeric G protein beta subunit that is required during embryonic development for the proper orientation of the mitotic spindle during early cell divisions and thus affects the orientation of early cell division axes, and is also required for larval viability, negatively regulates locomotion and egg-laying, and may affect germline development and osmotic balance; expressed in early embryos with highest expression at cell membranes and colocalizes with asters just before and during early cell divisions (this localization is dependent upon G alpha subunits); adults display high levels of expression in neurons with lower expression in the somatic gonad, vulva, and hypodermal seam cells and expression is also detected in the intestine, pharynx, body wall muscles and in the germline. F13D12.8 F13D12.8 Protein of unknown function F13D2.1 F13D2.1 Protein containing an alpha-2-macroglobulin C-terminal domain, which are found in protease inhibitors alpha-1-macroglobulin-like domain F13D2.2 F13D2.2 Member of the rhodopsin family of G protein-coupled receptors (GPCR), has a region of low similarity to a region of oxytocin receptor (rat Oxtr), which is induced in the uterus prior to labor G-protein coupled receptor F13D2.3 F13D2.3 Member of the rhodopsin family of G protein-coupled receptors (GPCR), has low similarity to uncharacterized C. elegans Y105C5A.23 G-protein coupled receptor F13D2.4 F13D2.4 Protein of unknown function F13E6.1 F13E6.1 Protein of unknown function with moderate similarity to H. sapiens TPD52L2 and H. sapiens TPD52 gene products, which are D52 tumor proteins D52 protein F13E6.2 F13E6.2 Protein of unknown function, has a region of low similarity to cytosolic adenylate kinase 1 (mouse Ak1), which acts in adenine nucleotide homeostasis, energetic homeostasis, and neuronal function adenylate kinase like F13E6.3 F13E6.3 Protein of unknown function, has weak similarity to C. elegans F21G4.4 F13E6.4 F13E6.4 Protein containing a WW domain, which bind proline-rich peptide epitopes RSP5 like protein F13E6.5 F13E6.5 Member of the phosphatidic acid phosphatase-related (PAP2) phosphoesterase family, has low similarity to phosphatidic acid phosphatase type 2a (rat Ppap2a), which catalyzes the dephosphorylation of various lipid phosphates F13E6.6 F13E6.6 Protein containing a phorbol esters or diacylglycerol binding domain (C1 domain), which bind two zinc ions, and a RhoGEF (GTPase exchange factor) domain, has low similarity to a region of rho (ARHA) guanine nucleotide exchange factor 12 (human ARHGEF12) Tiam-1 like protein; tag-118/F13E6.6 is orthologous to the human gene RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR 12 (ARHGEF12; OMIM:604763), which, when fused to the MLL gene (OMIM:159555), leads to primary acute myeloid leukemia. F13E9.1 F13E9.1 Protein containing leucine rich repeats, which mediate protein-protein interactions, has high similarity to a region of nischarin (mouse Nisch), which associates with integrin alpha5-beta1 and inhibits integrin-mediated cell migration SD22 like protein F13E9.10 F13E9.10 Protein of unknown function, has weak similarity to C. elegans ZK596.1 F13E9.11 F13E9.11 Protein of unknown function F13E9.2 F13E9.2 Protein of unknown function, has weak similarity to C. elegans F13E9.3 F13E9.3 F13E9.3 Protein of unknown function, has similarity to Synechocystis 6803 BtpA (biogenesis of thylakoid protein A) F13E9.4 F13E9.4 Protein containing one DUF148 domain of unknown function F13E9.5 F13E9.5 Protein of unknown function F13E9.6 F13E9.6 Protein of unknown function F13E9.7 F13E9.7 Protein of unknown function, has moderate similarity to C. elegans C17B7.6 reverse transcriptase F13E9.8 F13E9.8 Protein containing two DUF148 domains of unknown function F13E9.9 F13E9.9 Protein of unknown function F13G11.1 F13G11.1 Protein containing two DM (dsx and mab-3) DNA binding domains F13G11.2 F13G11.2 Protein of unknown function F13G3.1 F13G3.1 Protein containing three C2H2 type zinc finger domains, which bind nucleic acids Zinc finger, C2H2 type F13G3.10 F13G3.10 Protein of unknown function F13G3.11 F13G3.11 Protein of unknown function F13G3.2 F13G3.2 Protein of unknown function, has high similarity to uncharacterized C. elegans K02A2.2, which is predicted to be a G protein-coupled receptor F13G3.3 F13G3.3 Protein containing a DUF23 domain of unknown function, has low similarity to uncharacterized C. elegans F49C12.5 F13G3.4 F13G3.4 Protein with moderate similarity to T-complex testis expressed 1 (rat Tctex1), which is a cytoplasmic dynein light chain that may play a role in vesicle targeting, spermatogenesis, and protein recruitment during cytokinesis F13G3.5 F13G3.5 Member of the inositol monophosphatase family, which participate in the inositol phosphate second messenger signaling pathway, has moderate similarity to a region of rat Impa1, which is an inositol(myo)-1(or 4)-monophosphatase myo-inositol-1-monophosphatase; This gene encodes a protein predicted by Eisenberg and coworkers, with 52% accuracy, to be mitochondrial. F13G3.6 F13G3.6 Member of the glycosyl transferase family 2 B.subtilis teichoic acids biosynthesis protein GGAB like; This gene encodes a protein predicted by Eisenberg and coworkers, with 68% accuracy, to be mitochondrial. F13G3.7 F13G3.7 Member of the mitochondrial carrier protein family of membrane transporters, has moderate similarity to uncharacterized C. elegans Y43C5B.3 Yeast mitochondrial carrier protein like F13G3.8 eat-5;F13G3.8 Member of the integral membrane innexin family, which are involved in the formation of gap junctions, has moderate similarity to C. elegans UNC-7, which is required in motor neurons for coordinated locomotion UNC-7 protein like; eat-5 encodes an innexin, expressed in pharyngeal muscle cell groups pm4 and pm5, that is required for synchronized pharyngeal muscle contractions, and for normal electrical connections between pharyngeal muscle cells; EAT-5 forms electrically permeable intercellular channels (gap junctions), with a predicted membrane topology analogous to that of connexins, which affects electrical coupling between different parts of the pharynx and thus affects feeding. F13G3.9 mif-3;F13G3.9 Protein with moderate similarity to members of the macrophage migration inhibitory factor (MIF) family, has moderate similarity to C. elegans C52E4.2 macrophage migratory inhibitory factor MIF like F13H10.1 F13H10.1 Protein of unknown function F13H10.2 F13H10.2 NADH pyrophosphatase NADH pyrophosphatase; The ndx-9 gene encodes a member of the NADH pyrophosphatase subfamily of the NUDIX hydrolases. F13H10.3 F13H10.3 Protein with weak similarity to S. cerevisiae YJR001W Yeast YEH4 like protein F13H10.4 F13H10.4 Putative glucosidase I (mannosyl-oligosaccharide glucosidase) with a predicted role in the processing of N-linked oligosaccharides F13H10.4 is orthologous to the human gene A-GLUCOSIDASE I (GCS1; OMIM:601336), which when mutated leads to disease. F13H10.5 F13H10.5 Protein containing a type I phosphodiesterase or nucleotide pyrophosphatase domain, has weak similarity to a region of rat Enpp1, which is an ectonucleotide pyrophosphatase-phosphodiesterase and a cell surface tumor and neural differentiation antigen F13H6.1 F13H6.1 Protein containing four C2H2 type zinc finger domains, which bind nucleic acids, has weak similarity to a region of B-cell CLL-lymphoma 11A (mouse Bcl11a), which is involved in the repression of transcription zinc-finger protein F13H6.2 F13H6.2 Protein of unknown function F13H6.3 F13H6.3 Member of the carboxylesterase protein family carboxylesterase F13H6.4 F13H6.4 Member of the carboxylesterase protein family carboxylesterase F13H6.5 F13H6.5 Member of the rhodopsin family of G protein-coupled receptors (GPCR) F13H8.1 F13H8.1 Protein of unknown function F13H8.10 F13H8.10 Protein of unknown function bpl-1 encodes an ortholog of biotin ligase/holocarboxylase synthetase (called biotin ligase in bacteria, and holocarboxylase synthetase in mammalian or animal systems); it is orthologous to human HOLOCARBOXYLASE SYNTHETASE (HLCS; OMIM:253270), which when mutated leads to HLCS deficiency. F13H8.11 F13H8.11 Protein with strong similarity to C. elegans W02B12.1 gene product F13H8.2 F13H8.2 Member of the WD repeat protein family beta transducin Trp-Asp domains; This gene encodes a protein predicted by Eisenberg and coworkers, with 68% accuracy, to be mitochondrial. F13H8.3 F13H8.3 Member of the inosine-uridine preferring nucleoside hydrolase family, contains a major sperm protein (MSP) domain, which are involved in sperm motility, has moderate similarity to uncharacterized C. elegans Y43F8C.13 F13H8.4 F13H8.4 Protein of unknown function F13H8.5 F13H8.5 Protein containing a DB module domain Phospholipase ADRAB-B (Rabbit); F13H8.5 encodes a protein with a domain of unknown function (DB; IPR002602) that is found in several worm proteins, and a glutamine/asparagine-rich domain. F13H8.6 F13H8.6 Protein of unknown function F13H8.7 F13H8.7 Putative beta-ureidopropionase (beta-alanine synthase), member of the beta-ureidopropionase branch of the nitrilase superfamily, which also includes Human LOC51733 and Rat Rn11110 that are involved in pyrimidine base catabolism and beta-alanine production beta-ureidopropionase (rat) F13H8.8 F13H8.8 Protein of unknown function, has low similarity to uncharacterized C. elegans M117.4 F13H8.9 F13H8.9 Member of the aminotransferases class-V family of pyridoxal-phosphate-dependent enzymes, has moderate similarity to selenocysteine lyase (mouse Scly), which catalyzes the degradation of L-selenocysteine to L-alanine and elemental selenium Nitrogen fixation (NIFS) F14A5.1 F14A5.1 Protein containing a nuclear hormone receptor C4-type zinc finger domain, which bind DNA and may be involved in regulation of transcription, has a region of low similarity to a region of peroxisome proliferator activated receptor delta (rat Ppard) Zinc finger, C4 type (two domains) F14B4.1 F14B4.1 Protein containing two epidermal growth factor-like domains, two low-density lipoprotein (LDL) receptor class A domains and four class B LDL receptor repeats, has low similarity to a region of C. elegans LRP-1, which is an LDL receptor-related protein LDL receptor-related protein F14B4.2 F14B4.2 Protein with high similarity to glucokinase (human GCK), which converts glucose to glucose-6-phosphate in the first step of glucose metabolism, member of the hexokinase family, which convert aldo- and keto-hexose sugars to hexose-6-phosphate hexokinase F14B4.3 F14B4.3 Member of the RNA polymerases beta subunit family, which are shared among all three types of eukaryotic RNA polymerases, has moderate similarity to the RNA polymerase I 127 kDa subunit (rat Rpo1-2), which is the second largest subunit of RNA polymerase I DNA-directed RNA polymerase I F14B6.1 F14B6.1 Protein with moderate similarity to C. elegans F14B6.3 gene product F14B6.2 F14B6.2 Protein with strong similarity to C. elegans F14B6.7 gene product F14B6.3 F14B6.3 Protein with moderate similarity to C. elegans F14B6.1 gene product F14B6.4 F14B6.4 Member of the galactosyltransferase family, has a region of low similarity to a region of UDP-galactose:beta-N-acetylglucosamine beta-1,3-galactosyltransferase (human B3GALT1), which is downregulated in colon adenocarcinomas F14B6.5 F14B6.5 Protein containing a DUF33 domain of unknown function, has high similarity to uncharacterized C. elegans F41D3.5 F14B6.6 F14B6.6 Member of the galactosyltransferase family, which transfer galactose to GlcNAc termini of growing oligosaccharide chains, has high similarity to uncharacterized C. elegans T09F5.1 F14B8.1 F14B8.1 Member of the sodium or hydrogen exchanger family, which maintain the pH of actively metabolizing cells, has low similarity to sodium-hydrogen exchanger 1 (human SLC9A1), which is an antiporter that plays a role in pH regulation and cell volume regulation NA(+)/H(+) antiporter; nhx-4 encodes two isoforms of a sodium/proton exchanger expressed in the plasma membrane of nearly all cells and cell types; in polarized epithelial cells, NHX-4::GFP appears specifically located in the basolateral membrane, like human SLC9A1 ('NHE1'; OMIM:107310); nhx-4 has no reported mutant or RNAi phenotype, but, given its ubiquitous expression, may represent a housekeeping exchanger generally required for cellular viability; transgenic NHX-4A, when expressed in cell culture, mediates Na[+]-dependent pH recovery after intracellular acidification, independently of extracellular Cl[-]. F14B8.2 F14B8.2 Protein of unknown function F14B8.3 F14B8.3 Member of the sugar (and other) transporter family, has weak similarity to a region of organic cationic transporter-like 1 (rat Orctl1), which mediates the exchange of organic anions, dicarboxylate, and para-aminohippurate F14B8.4 F14B8.4 Protein of unknown function F14B8.5 F14B8.5 Protein of unknown function, has strong similarity to C. elegans B0212.1 F14B8.6 F14B8.6 Protein of unknown function F14B8.7 F14B8.7 Putative ortholog of C. elegans B0212.1 gene product F14D12.1 F14D12.1 Protein with weak similarity to S. cerevisiae MUC1 (Cell surface flocculin, required for invasive and pseudohyphal growth) F14D12.2 unc-97;F14D12.2 Member of the PINCH family of LIM-only proteins; component of the integrin complex at hypodermal-muscle attachment sites LIM domain containing protein; The unc-97 gene encodes a LIM domain-containing protein of the PINCH family that is highly similar to human LIMS1 (OMIM:602567) and LIMS2; UNC-97 func