Gene_cosmid_name All names Proteome description WormBase description ------------------------------------------------------------------------------ 116A8A.E Y116A8C.21;116A8A.E Protein of unknown function, has low similarity to uncharacterized C. elegans Y116F11A.4 1G758 1G758 Protein that interacts with the Hsp70 chaperone 2L52.A 2L52.1;2L52.A Protein containing two C2H2 type zinc finger domains, which bind nucleic acids 2L737 2L737 Putative ortholog of C. elegans VW02B12L.4 gene product 2O676 2O676 Protein with moderate similarity to C. elegans F26H11.1 gene product 3I332 3I332 Proteasome component C5 3I940 3I940 Putative ortholog of C. elegans F44E2.9 gene product 3R5.1 3R5.1 Protein of unknown function, has high similarity to uncharacterized C. elegans F57C2.3 3R5.2 3R5.2 Putative ortholog of C. elegans K08E3.8 gene product 4D561 4D561 Putative ortholog of C. elegans Y94H6A_1.A gene product 4F223 4F223 Putative ortholog of C. elegans R08C7.12 gene product 4R79.1 4R79.1 Member of the astacin (M12A) family of metalloproteases, has a region of moderate similarity to a region of the beta subunit of meprin A (rat Mep1b), which is an integral membrane protein that may play a role in embryogenesis Zinc-binding metalloprotease domain 4R79.2 4R79.2 Member of the Ras superfamily of GTP-binding proteins, has a region of moderate similarity to S. cerevisiae Sec4p, which is a GTP-binding protein involved in vesicular transport between the Golgi and plasma membrane Ras family 4R79.3 F11E6.1;4R79.3 Member of the glycosyl hydrolase family 30, which are glucosyl-ceramidases, has moderate similarity to acid beta glucosidase (beta-glucocerebrosidase, mouse Gba), which is a lysosomal membrane protein that hydrolyzes glucosylceramide 5C820 5C820 Putative ortholog of C. elegans F15E11.12 gene product 5HT3-CE 5HT3-Ce Member of the rhodopsin family of G protein-coupled receptors (GPCR), has moderate similarity to 5-hydroxytryptamine (serotonin) 1A receptor (mouse Htr1a), which is a G protein-coupled receptor that acts via Gi-Go to inhibit adenylyl cyclase 5N224 5N224 Protein with strong similarity to C. elegans C15C8.7 gene product 6R55.1 6R55.1 Putative ortholog of C. elegans 6R55.1 gene product 6R55.2 6R55.2 Protein of unknown function 9F54G8.5 ptr;9F54G8.5 Member of the patched family, which are transmembrane receptors, has weak similarity to a region of Niemann-Pick disease type C1 (human NPC1), which is a lysosomal protein that plays a role cholesterol transport AC3.1 AC3.1 Member of the 7-transmembrane chemoreceptor family of G protein-coupled receptors (GPCR), has low similarity to uncharacterized C. elegans F34D6.6 7TM chemoreceptor, sri family AC3.2 AC3.2 Protein containing four UDP-glucoronosyl and UDP-glucosyl transferase domains, which transfer glycosyl groups to small hydrophobic molecules, has a region of low similarity to UDP glycosyltransferase 1 A3 (human UGT1A3) UDP-glucuronosyltransferase AC3.3 AC3.3 Protein containing eleven uncharacterized cysteine repeat domains, has strong similarity to uncharacterized C. elegans Y73F8A.9 abu-1 encodes a transmembrane protein with a predicted signal sequence, a glutamine/asparagine-rich domain and multiple cysteine-rich repeats (DUF139); abu-1 expression is induced by blockage of the unfolded-protein response in the endoplasmic reticulum, and ABU-1 may help protect the organism from damage by improperly folded nascent protein. AC3.4 AC3.4 Protein containing a DHHC-type zinc finger NEW1 domain, has a region of low similarity to a region of Huntingtin interacting protein H (human HYPH), which interacts with huntingtin (human HD) and may play a role in Huntington disease The protein product of this gene is predicted to contain a glutamine/asparagine (Q/N)-rich ('prion') domain, by the algorithm of Michelitsch and Weissman (as of the WS77 release of WormBase, i.e., in wormpep77). AC3.5 AC3.5 Member of the M1 peptidase family of aminopeptidases, has weak similarity to leucine aminopeptidase (oxytocinase, human LNPEP), which is an insulin-regulated zinc aminopeptidase that degrades oxytocin and vasopressin glutamyl aminopeptidase AC3.6 AC3.6 Protein containing two collagen triple helix repeats, which are found in some extracellular proteins, and a nematode cuticle collagen N-terminal domain, has a region of moderate similarity to a region of C. elegans BLI-1 collagen AC3.7 AC3.7 Protein containing a UDP-glucoronosyl and UDP-glucosyl transferase domain, which transfer glycosyl groups to small hydrophobic molecules, has weak similarity to UDP-glycosyltransferase 1 A9 (human UGT1A9), which plays a role in drug metabolism UDP-glucuronosyltransferase AC3.8 AC3.8 Protein containing a UDP-glucoronosyl and UDP-glucosyl transferase domain, which transfer glycosyl groups to small hydrophobic molecules, has weak similarity to UDP glycosyltransferase 1 family polypeptide A6 (mouse Ugt1a6) UDP-glucuronosyltransferase AC7.1 AC7.1 Member of the rhodopsin family of G protein-coupled receptors (GPCR), has low similarity to tachykinin receptor 1 (substance P receptor, rat TACR1), is involved in pain transmission, inflammation, perception of noxious stimuli, and behavior G-protein coupled receptor AC7.2 soc-2;sur-8;AC7.2 Positive regulator of the let-60 ras pathway and vulval induction AC7.3 AC7.3 Protein of unknown function AC8.6 AC8.6 Protein of unknown function, has strong similarity to C. elegans AC8.J AC8.B AC8.2;AC8.B Putative ortholog of C. elegans Y71F9AL.2 gene product AC8.D AC8.1;AC8.A;AC8.D Protein containing a poly(ADP-ribose) polymerase regulatory domain, a Poly(ADP-ribose) polymerase zinc finger domain, and a Poly(ADP-ribose) polymerase catalytic domain, has low similarity to mouse Adprt1, which plays a role in DNA damage response AC8.E AC8.7;AC8.E Protein of unknown function, has weak similarity to C. elegans F25G6.1 AC8.F AC8.3;AC8.F Protein of unknown function, has low similarity to uncharacterized C. elegans F25G6.1 AC8.G AC8.4;AC8.G Protein of unknown function, has weak similarity to C. elegans H12D21.8 AC8.I AC8.5;AC8.I Protein of unknown function, has high similarity to uncharacterized C. elegans Y48E1B.7 ADS-1 ads-1 Alkyl-dihydroxyacetonephosphate synthase AH10.1 AH10.1 Member of the AMP-binding enzyme family, has low similarity to C. albicans Acs1p, which is an acetyl-coenzyme A synthetase (acetate-coA ligase) 4-coumarate:coenzyme A ligase AH10.2 AH10.2 Protein of unknown function, has high similarity to uncharacterized C. elegans Y75B12A.2 AH10.3 AH10.3 Protein of unknown function AH10.4 AH10.4 Protein of unknown function, has strong similarity to uncharacterized C. elegans ZK84.4 AH10.5 AH10.5 Small protein of unknown function, identical to a region in the N-terminus of C. elegans PAR-1 AH6.1 gcy-1;AH6.1 Putative guanylyl cyclase guanylate cyclase; gcy-1 is predicted to encode a guanylate cyclase; however, transcriptional fusions of the putative upstream regulatory region with a GFP reporter did not confirm its expression. AH6.10 sra-6;AH6.10 G protein-coupled receptor, expressed in chemosensory neurons, no homolog found in human or D. melanogaster 7TM chemoreceptor, sra family AH6.11 sra-7;AH6.11 G protein-coupled receptor, expressed in chemosensory neurons, no homolog found in human or D. melanogaster 7TM chemoreceptor, sra family AH6.12 sra-8;AH6.12 G protein-coupled receptor; member of a subfamily with SRA proteins, which are expressed in chemosensory neurons; no homolog found in human or D. melanogaster 7TM chemoreceptor, sra family AH6.13 AH6.13 Member of C. elegans Sra integral membrane protein family, which contain 6-7 hydrophobic, putative transmembrane, regions, has moderate similarity to uncharacterized C. elegans SRA-2 AH6.14 sra-9;AH6.14 G protein-coupled receptor, expressed in chemosensory neurons, no homolog found in human or D. melanogaster 7TM chemoreceptor, sra family AH6.2 AH6.2 Member of the mitochondrial tricarboxylate carrier (MTC) protein family AH6.3 AH6.3 Protein of unknown function, has weak similarity to the DNA-binding domain of the human nucleoplasmic protein NP220(Hs.169984) AH6.4 sra-1;AH6.4 G protein-coupled receptor, expressed in chemosensory neurons, no homolog found in human or D. melanogaster 7TM chemoreceptor, sra family; sra-1 encodes a predicted seven transmembrane receptor; expressed in the male SPD and SPV neurons. AH6.5 mex-6;AH6.5 Non-essential protein that appears to have partially overlapping function with MEX-5 in repression of germline-specific proteins in the anterior of embryos zinc finger protein; mex-6 encodes a CCCH zinc-finger protein highly similar to MEX-5 that functions with MEX-5 to affect embryonic viability, establish soma germline asymmetry in embryos and establish PIE-1, MEX-1, and POS-1 asymmetry in embryos, and also affects formation of intestinal cells; MEX-6 and MEX-5 may act downstream of the PAR proteins. AH6.6 sra-2;AH6.6 Member of the 7TM receptor protein family 7TM chemoreceptor, sra family AH6.7 sra-3;AH6.7 G protein-coupled receptor; member of a subfamily with SRA proteins, which are expressed in chemosensory neurons; no homolog found in human or D. melanogaster 7TM chemoreceptor, sra family AH6.8 sra-4;AH6.8 G protein-coupled receptor; member of a subfamily with SRA proteins, which are expressed in chemosensory neurons; no homolog found in human or D. melanogaster 7TM chemoreceptor, sra family AH6.9 sra-5;AH6.9 G protein-coupled receptor; member of a subfamily with SRA proteins, which are expressed in chemosensory neurons; no homolog found in human or D. melanogaster AH9.1 AH9.1 Member of the rhodopsin family of G protein-coupled receptors (GPCR), has low similarity to uncharacterized C. elegans B0563.6 transmembrane domain of family 1 of G-protein coupled receptors AH9.2 AH9.2 Member of the exonuclease family AH9.3 AH9.3 Protein of unknown function AH9.4 AH9.4 Protein of unknown function ASC-1 asc-1 Protein with similarity to human TRIP4, which interacts with the ligand binding domain of the thyroid hormone receptor to activate transcription ATPASE6 ATP6;ATPase6 Member of the ATP synthase A chain family B0001.1 B0001.1 Protein of unknown function, has low similarity to uncharacterized C. elegans C31H1.6 B0001.2 B0001.2 Protein with moderate similarity to C. elegans C49A9.1 gene product B0001.3 B0001.3 Protein with moderate similarity to C. elegans B0001.5 gene product B0001.4 B0001.4 Protein with high similarity to uridine monophosphate kinase (human UMPK), which phosphorylates uridine, cytidine, and their analogs and functions in pyrimidine nucleoside and drug metabolism, member of the phosphoribulokinase and uridine kinase family uridine kinase like B0001.5 B0001.5 Protein of unknown function, has low similarity to uncharacterized C. elegans B0001.8 B0001.6 B0001.6 Coiled-coil protein of unknown function, has similarity over coiled-coil regions to S. cerevisiae Mlp1p and Num1p B0001.7 B0001.7 Protein of unknown function B0001.8 B0001.8 Protein with strong similarity to C. elegans B0001.5 gene product B0019.1 B0019.1 Protein with similarity over N-terminal half to human monoamine oxidases MAOA and MAOB B0019.2 B0019.2 Protein with strong similarity to C. elegans F28H6.5 gene product B0019.3 B0019.3 Protein with strong similarity to the C. elegans Y18D10A.A gene product B0024.1 B0024.1 Protein containing two collagen triple helix repeats, which are found in some extracellular proteins, and a nematode cuticle collagen N-terminal domain, has moderate similarity to a region of C. elegans BLI-1 collagen B0024.10 B0024.10 Protein of unknown function, has weak similarity to human myosin MYH9 and laminin LAMB1 B0024.11 B0024.11 Member of the uncharacterized protein family UPF0024, has low similarity to uncharacterized S. pombe Spbc1a4.09p Uncharacterized protein family UPF0024 B0024.12 gna-1;CeGNA1;B0024.12 Protein containing an acetyltransferase (GNAT) domain, has moderate similarity to glucosamine-phosphate N-acetyltransferase 1 (mouse Gpnat1), which is an apoptosis regulator acting in O-glycosylation, N-acetylglucosamine synthesis and actin polymerization Acetyltransferase (GNAT) family; gna-1 encodes one of two C. elegans glucosamine 6-phosphate N-acetyltransferases (GNAs); by homology, GNA-1 is predicted to be required for the formation of UDP-N-acetylglucosamine, a substrate in chitin synthesis, Golgi and cytoplasmic glycosylation, and GPI anchoring; as loss of gna-1 activity via large-scale RNAi screens does not result in any obvious abnormalities, the precise role of GNA-1 in C. elegans development and/or behavior is not yet known. B0024.13 B0024.13 Member of the 3-oxo-5-alpha-steroid 4-dehydrogenase family, which are involved in dihydrotestosterone biosynthesis, has low similarity to S. cerevisiae Dfg10p, which is involved in filamentous growth, cell polarity, and cellular elongation B0024.14 B0024.14 Member of the antistasin family, which are inhibitors of trypsin family proteases, contains four von Willebrand factor (vWF) type C domains, has a region of weak similarity to a region of nel-related protein 2 (rat Nell2), which binds heparin pro-collagen domains B0024.2 B0024.2 Protein containing two collagen triple helix repeats, which are found in some extracellular proteins, and a nematode cuticle collagen N-terminal domain, has low similarity to C. elegans ROL-6 collagen B0024.3 B0024.3 Member of the galactosyltransferase family, which transfer galactose to GlcNAc termini of growing oligosaccharide chains, has a region of low similarity to UDP-galactose:beta-N-acetylglucosamine beta-1,3-galactosyltransferase (human B3GALT1) B0024.4 B0024.4 Protein of unknown function, has moderate similarity to uncharacterized C. elegans ZK6.10 B0024.6 gcy-6;B0024.6 Putative guanylyl cyclase expressed in the ASEL neuron guanylate cyclase (2 domains); gcy-6 encodes a predicted guanylate cyclase; expressed in the ASEL neurons. B0024.8 B0024.8 Putative ortholog of C. elegans B0024.5 gene product B0024.9 B0024.9 Member of the thioredoxin protein family, which are small enzymes involved in redox reactions, has low similarity to thioredoxin I (S. cerevisiae Trx1p) thioredoxin; This gene encodes a protein predicted by Eisenberg and coworkers, with 52% accuracy, to be mitochondrial. B0025.1 let-512;vps-34;B0025.1 Protein containing two PIK domains (phosphoinositide 3-kinase accessory domains), a phosphoinositide 3-kinase C2 domain, and two phosphatidylinositol 3- and 4-kinase domains, has moderate similarity to phosphatidylinositol 3-kinase class 3 (rat Pik3c3) phosphatidylinositol 3-kinase; The vps-34 gene encodes an ortholog of the phosphoinositide 3-kinase VPS34 in S. cerevisiae, a protein that regulates multiple steps in endocytosis, and that is required for growth at normal rates during development. B0025.2 B0025.2 Protein with high similarity to thyroid receptor interacting protein 15 (human TRIP15), which is a nuclear hormone transcription corepressor, contains a PCI (proteasome, COP9-complex and eIF3 ) or PINT (Proteasome, Int-6, Nip-1 and TRIP-15) domain csn-2 encodes a homolog of COP9 signalosome complex subunit 2 that affects embryonic viability and growth rate. B0025.4 B0025.4 Protein of unknown function B0034.1 B0034.1 Protein of unknown function B0034.2 B0034.2 Protein of unknown function B0034.3 cdh-11;B0034.3 Protein containing a cadherin domain, which are found in the extracellular domain of some receptors and cell adhesion proteins, has low similarity to uncharacterized human KIAA0911 A homolog of a member of the cadherin superfamily which is involved in cell-cell adhesion. B0034.4 B0034.4 Protein of unknown function B0034.5 B0034.5 Protein with strong similarity to C. elegans R11F4.2 gene product B0035.1 B0035.1 Protein of unknown function, has moderate similarity to uncharacterized zinc finger protein 207 (human ZNF207) Zinc finger, C2H2 type B0035.10 B0035.10 Member of the histone H3 protein family histone H3; his-45 encodes an H3 histone. B0035.11 B0035.11 Protein of unknown function, has low similarity to uncharacterized S. cerevisiae Leo1p Yeast LEO1 protein like B0035.12 B0035.12 Protein related to human nuclear RNA binding protein p110nrb polyadenylate-binding protein like B0035.13 B0035.13 Member of the lipase class 3 family, which are a subset of lipolytic enzymes that hydrolyze ester linkages of triglycerides, has high similarity to uncharacterized C. elegans F28H7.3 lipase B0035.14 B0035.14 Protein containing a DnaJ domain, which are part of chaperone system that mediates interaction with heat shock proteins, has a region of moderate similarity to a region of dnaJ homolog subfamily B member 4 (human DNAJB4), which is a heat shock protein DNAJ protein like; This gene encodes a protein containing a DnaJ ('J') domain. B0035.15 B0035.15 Protein of unknown function B0035.16 B0035.16 Member of the tRNA methyl transferase family, which are involved in nucleoside 5-methylaminomethyl-2-thiouridine biosynthesis, has low similarity to uncharacterized S. pombe SPAC23H4.04 Haemophilus hypothetical protein HI1074 like; This gene encodes a protein predicted by Eisenberg and coworkers, with 68% accuracy, to be mitochondrial. B0035.2 B0035.2 Protein containing a DnaJ domain, which are part of the chaperone (protein folding) system that mediates interaction with heat shock proteins DNAJ protein like; This gene encodes a protein containing a DnaJ ('J') domain. B0035.3 B0035.3 Member of the Appr-1 double prime-p processing enzyme family viral non-structural protein like B0035.4 B0035.4;4M79 Protein of unknown function; has moderate similarity to H. sapiens PFDN4 (prefoldin 4), which may have a role in cell cycle paramyosin like B0035.5 B0035.5 Protein with high similarity to glucose-6-phosphate dehydrogenase (human G6PD), which is involved in the pentose phosphate pathway and is associated with hemolytic anemia, contains glucose-6-phosphate dehydrogenase C-terminal and NAD binding domains glucose-6-phosphate-1-dehydrogenase; B0035.5 is orthologous to the human gene GLUCOSE-6-PHOSPHATE DEHYDROGENASE (G6PD; OMIM:305900), which when mutated leads to disease. B0035.6 B0035.6 Protein of unknown function, has high similarity to uncharacterized C. elegans Y111B2A.3 B0035.7 B0035.7 Protein with strong similarity to H2A histone family member X (mouse H2afx), which binds DNA during nucleosome formation and is phosphorylated following DNA double-strand breaks in recombination, member of the histone family of nucleosomal core proteins histone H2A; his-47 encodes an H2A histone; by homology, HIS-47 is predicted to function as a nucleosome component required for packaging of DNA into chromatin; his-47 is a replication-dependent histone locus that resides in a histone gene-rich region on chromosome IV. B0035.8 B0035.8 Protein with high similarity to histone H2B (S. cerevisiae Htb1p), which binds chromatin, member of the histone family of nucleosomal core proteins histone H2B; his-48 encodes an H2B histone; by homology, HIS-48 is predicted to function as a nucleosome component required for packaging of DNA into chromatin; his-48 is a replication-dependent histone locus that resides in a histone gene-rich region on chromosome IV. B0035.9 B0035.9 Protein with very strong similarity to H4 histone family member E (human H4FE), which is a chromatin assembly complex component involved in the condensation of DNA into nucleosomes, member of the histone family of nucleosomal core proteins histone H4; his-46 encodes an H4 histone. B0041.1 B0041.1 Protein of unknown function B0041.2 B0041.2 Protein of unknown function, has low similarity to uncharacterized C. elegans C06G1.4 B0041.3 B0041.3 Protein containing a LysM domain, which may bind peptidoglycans B0041.4 rpl-1;B0041.4 Protein with high similarity to ribosomal protein L4 (rat Rpl4), which is a large 60S ribosomal subunit protein that binds 5S RNA and is involved in apoptosis, member of the ribosomal L4 or L1 family ribosomal protein L1; rpl-4 encodes a large ribosomal subunit L4 protein. B0041.5 B0041.5 Protein of unknown function, has weak similarity to uncharacterized S. pombe Spbc405.03cp B0041.6 B0041.6 Protein with high similarity to 6-pyruvoyltetrahydropterin synthase (mouse Pts), which catalyzes the second step in the biosynthesis of tetrahydrobiopterin, member of the 6-pyruvoyl tetrahydropterin synthase family 6-pyruvoyl tetrahydrobioterin synthase; B0041.6 is orthologous to the human gene 6-PYRUVOYLTETRAHYDROPTERIN SYNTHASE (PTS; OMIM:261640), which when mutated leads to disease. B0041.7 xnp-1;B0041.7 Protein containing a helicase conserved C-terminal domain and an SNF2 related N-terminal domain, has moderate similarity to a region of mouse Xnp, which may be a transcriptional regulator in DNA repair, DNA recombination, and neuronal differentiation helicase; xnp-1 is orthologous to the human gene ATR-X (OMIM:300032), which when mutated leads to ATR-X syndrome (OMIM:301040); xnp-1 is also homologous to human nibrin, which when mutated leads to Nigmegen breakage syndrome (OMIM:251260). B0041.8 B0041.8 Protein of unknown function B0047.1 B0047.1 Protein containing a meprin and TRAF homology (MATH) domain and a BTB (BR-C, ttk and babor) or POZ (Pox virus and zinc finger) domain, which may mediate protein-protein interactions, has moderate similarity to uncharacterized C. elegans R52.1 B0047.2 B0047.2 Protein containing a BTB (BR-C, ttk and babor) or POZ (Pox virus and zinc finger) domain, which are found in some DNA and actin binding proteins and may mediate protein-protein interactions, has high similarity to uncharacterized C. elegans F47C10.2 B0047.3 B0047.3 Protein containing a meprin and TRAF homology (MATH) domain and a BTB (BR-C, ttkand babor) or POZ (Pox virus and zinc finger) domain, which are found in some DNA and actin binding proteins, has high similarity to uncharacterized C. elegans F52C6.11 B0047.4 B0047.4 Protein containing a meprin and TRAF homology (MATH) domain B0047.5 B0047.5 Protein containing a meprin and TRAF homology (MATH) domain and a BTB (BR-C, ttk and babor) or POZ (Pox virus and zinc finger) domain, has high similarity to uncharacterized C. elegans F52C6.8 B0198.1 B0198.1 Member of the tetraspanin family, which contain an N-terminal transmembrane domain that is a signal sequence and membrane anchor, has low similarity to platelet endothelial tetraspan antigen 3 (human CD151), which mediates cell adhesion and cell migration tetraspanin B0198.2 B0198.2 Protein of unknown function B0198.3 B0198.3 Protein with high similarity to C. elegans MES-1, which is required for asymmetric divisions of the germline in early C. elegans embryos, contains two protein kinase domains protein kinase B0205.1 B0205.1 Protein of unknown function, has moderate similarity to uncharacterized C. elegans B0212.3 B0205.10 B0205.10 Protein of unknown function, has high similarity to uncharacterized C. elegans B0379.7 B0205.11 B0205.11 Protein of unknown function B0205.2 B0205.2 Member of an uncharacterized protein family 7TM chemoreceptor, srz family B0205.3 rpn-10;B0205.3 Protein with high similarity to proteasome 26S subunit non ATPase 4 (human PSMD4), which is an antisecretory factor that is a subunit of the 26S proteasome and may bind to multiubiquitinated proteins, contains two ubiquitin interaction motifs rpn-10 encodes a protein that contains two ubiquitin interaction motifs and is a member of the von Willebrand factor, type A superfamily similar to the mouse 26S proteasome non-ATP regulatory subunit 4. B0205.4 B0205.4 Member of the glycosyl transferase family 11, which hydrolyze the glycosidic bond between two or more carbohydrates, has a region of low similarity to a region of fucosyltransferase 2 (rat Fut2), which controls soluble blood group antigen synthesis The B0205.4 gene encodes a homolog of the human gene FUT1, which when mutated leads to leukocyte adhesion deficiency, type II (OMIM:266265). B0205.5 B0205.5 Protein of unknown function, has weak similarity to C. elegans Y18D10A.A B0205.6 B0205.6 Member of the cysteine desulfurase protein family aminotransferase B0205.7 B0205.7;CKIIalpha Casein kinase II, alpha subunit casein kinase; kin-3 encodes an ortholog of the catalytic subunit of casein kinase II alpha, which in Drosophila and mammals is required for normal circadian rhythms, and which directly phosphorylates the Drosophila PERIOD protein (which itself regulates circadian rhythms); by analogy, KIN-3 might be expected to help regulate heterochronic functions dependent on such proteins as LIN-42. B0205.8 B0205.8 Protein of unknown function B0205.9 B0205.9 Protein of unknown function, has high similarity to uncharacterized C. elegans B0212.3 B0207.1 B0207.1 Member of the protein-tyrosine phosphatase family, which are involved in cell growth control, proliferation, differentiation and transformation, has a region of low similarity to C. elegans F10G8.1, which is involved in embryogenesis or morphogenesis protein-tyrosine phophatase B0207.10 B0207.10 Protein of unknown function B0207.11 B0207.11 Protein of unknown function, has high similarity to uncharacterized C. elegans T08G11.2 B0207.12 avr-14;gbr-2;GluClX;B0207.12 Protein with high similarity to C. elegans GLC-1, which is an avermectin-sensitive glutamate-gated chloride channel GluCl-alpha subunit, contains five neurotransmitter-gated ion-channel ligand binding and six transmembrane domains avr-14 encodes an alpha-type subunit of a glutamate-gated chloride channel homologous to human GLRA2, which when mutated leads to hyperekplexia (OMIM:149400); AVR-14 affects sensitivity to the antiparisitic drug, ivermectin, in parallel with avr-15 and glc-1 and in a genetic pathway with unc-9; it functions in the extrapharyngeal nervous system, and is expressed in a subset of neurons in the ring ganglia, ventral cord, and some mechanosensory neurons. B0207.2 B0207.2 Protein of unknown function B0207.3 gpa-14;B0207.3 Member of the G protein alpha subunit family guanine nucleotide-binding protein, alpha subunit; gpa-14 encodes a member of the G protein alpha subunit family of heterotrimeric GTPases; gpa-14 is expressed in ASI, ASJ, ASH, ASK, ADE, PHA, PHB ALA, AVA, CAN, DVA, PVQ, RIA, and in vulval muscle, and also exhibits faint expression in the vulval hypodermis. B0207.4 air-2;let-603;B0207.4 Member of the aurora subfamily of serine/threonine protein kinases; associated with mitotic chromosomes; probably required for chromosome segregation, cytokinesis and polar body extrusion protein kinase; air-2 encodes an aurora/Ip11-related serine/threonine protein kinase that affects embryonic viability and chromosome segregation during meiosis and mitosis and is required for cytokinesis; AIR-2 has two functions during mitosis, one in chromosome segregation, and a second, independent function in cytokinesis through ZEN-4; AIR-2 and ZEN-4 may act in parallel to a second pathway that includes CYK-1; AIR-2 phosphorylates two adjacent, evolutionarily conserved C-terminal serines of the inner centromere protein ICP-1; AIR-2 forms a robust complex with CSC-1, BIR-1, and ICP-1; air-2 is expressed highly in embryos, in the mature oocytes, spermatocytes, and extruded polar bodies. B0207.5 B0207.5 Putative ortholog of C. elegans Y76G2B.C gene product B0207.6 B0207.6 Member of the conserved hypothetical ATP binding protein family, has low similarity to a region of XPA binding protein 1 (human NTPBP), which is a cytoplasmic GTPase that binds xeroderma pigmentosum group A protein (XPA) B0207.7 B0207.7 Protein containing a protein kinase domain, has low similarity to casein kinase 1 alpha 1 (human CSNK1A1), which is a serine-threonine protein kinase that may play a role in Alzheimer's disease serine/threonine-protein kinase B0207.8 B0207.8 Protein of unknown function B0207.9 B0207.9 Protein of unknown function B0212.1 B0212.1 Protein of unknown function, has moderate similarity to uncharacterized C. elegans F14B8.7 B0212.2 B0212.2 Member of the C. elegans Sre G protein-coupled chemoreceptor family, which are putative chemosensory receptors 7TM chemoreceptor, sre family B0212.3 B0212.3 Protein of unknown function, has high similarity to uncharacterized C. elegans M57.1 B0212.4 B0212.4 Protein containing two uncharacterized domains DUF6, has low similarity to solute carrier family 35 (UDP-N-acetylglucosamine(UDP-GlcNAc) transporter) member 3 (human SLC35A3), which transports nucleotide sugars B0212.5 osm-9;B0212.5 Predicted six transmembrane domain channel protein required for mechanosensation, AWA-mediated olfactory responses, AWC-mediated olfactory adaptation, and ASH-mediated avoidance responses olfacory channel; The osm-9 gene encodes a capsaicin receptor homolog involved in sensory responses to a subset of chemical stimuli and to ASH neuron-mediated osmotic and mechanical stimuli; OSM-9 is also involved in adaptation to volatile odorants and salts. B0213.1 B0213.1 TcA transposase B0213.10 B0213.10 Member of the cytochrome P450 family, has low similarity to cytochrome P450 2C18 (human CYP2C18), which non-stereospecifically catalyzes 4'-hydroxylation of (S)-mephenytoin and retinoic acid and metabolizes a variety of unrelated compounds and drugs cytochrome P450 B0213.11 B0213.11 Member of the cytochrome P450 family, has low similarity to nicotine C-oxidase (cytochrome P450 2A6) (human CYP2A6), which functions in oxidizing precarcinogens and drugs cytochrome P-450 B0213.12 B0213.12 Member of the cytochrome P450 family, has low similarity to cytochrome P450 2C18 (human CYP2C18), which catalyzes 4'-hydroxylation of (S)-mephenytoin and retinoic acid and metabolizes various compounds and drugs including anti-inflammatory agents cytochrome P450 B0213.14 B0213.14 Member of the cytochrome P450 family, has low similarity to cytochrome P450 2c29 (mouse Cyp2c29), which is a major cannabinoid metabolizing enzyme in liver microsomes and involved in detoxification of xenobiotics and drugs cytochrome P450 B0213.15 B0213.15 Member of the cytochrome P450 family, has low similarity to cytochrome P450 subfamily IIJ5 (mouse Cyp2j5), which is a heme-thiolate protein involved in the catalysis of NADPH-dependent oxidation of arachidonic acid to eicosanoids cytochrome P450 B0213.16 B0213.16 Member of the cytochrome P450 family, has low similarity to cytochrome P450 2c29 (mouse Cyp2c29), which is a major cannabinoid metabolizing enzyme in liver microsomes and involved in detoxification of xenobiotics and drugs cytochrome P-450 B0213.2 nlp-27;B0213.2 YGGWamide neurotransmitter nlp-27 encodes a predicted neuropeptide with homology to C. elegans nlp-28 through nlp-31. B0213.3 nlp-28;B0213.3 YGGWamide neurotransmitter B0213.4 nlp-29;B0213.4 YGGWamide neurotransmitter B0213.5 B0213.5 YGGWamide neurotransmitter nlp-30 encodes five predicted neuropeptide-like proteins; in C. elegans, nlp-30 is part of the YGGWamide neuropeptide family that also contains nlp-24, nlp-25, and nlp-27-32; nlp-30 is expressed in the hypodermis, suggesting that the peptides it encodes may have a non-neuronal function; as loss of nlp-30 activity via large-scale RNAi screens does not result in any obvious abnormalities, the precise role of the nlp-30-encoded peptides in development and/or behavior is not yet known. B0213.6 B0213.6 YGGWamide neurotransmitter nlp-31 encodes five predicted neuropeptide-like proteins; in C. elegans, nlp-31 is part of the YGGWamide neuropeptide family that also contains nlp-24, nlp-25, and nlp-27-32; nlp-31 is expressed in the hypodermis, suggesting that the peptides it encodes may have a non-neuronal function; nlp-31 expression is also detected in precomma-stage embryos; as loss of nlp-31 activity via large-scale RNAi screens does not result in any obvious abnormalities, the precise role of the nlp-31-encoded peptides in development and/or behavior is not yet known. B0213.7 B0213.7 Member of the 7-transmembrane chemoreceptor family of G protein-coupled receptors (GPCR), has weak similarity to C. elegans ODR-10, which is a G protein-coupled receptor involved in odorant response 7TM chemoreceptor, str family B0213.8 B0213.8 Member of the 7-transmembrane chemoreceptor family of G protein-coupled receptors (GPCR), has weak similarity to C. elegans ODR-10, which is a G protein-coupled receptor involved in odorant response 7TM chemoreceptor, str family B0213.9 B0213.9 Member of the 7-transmembrane chemoreceptor family of G protein-coupled receptors (GPCR), has low similarity to C. elegans ODR-10, which is a G protein-coupled receptor involved in odorant response 7TM chemoreceptor, str family B0218.1 B0218.1 Member of the amidase family, which catalyze hydrolysis of amides, has moderate similarity to fatty acid amide hydrolase (rat Faah), which is a serine hydrolase that degrades neuromodulatory fatty acid amides thereby terminating their signaling function amidase B0218.2 B0218.2 Member of the amidase family, which catalyze hydrolysis of amides, has moderate similarity to fatty acid amide hydrolase (rat Faah), which is a serine hydrolase that degrades neuromodulatory fatty acid amides thereby terminating their signaling function amidase B0218.3 pmk-1;B0218.3 Serine/threonine protein kinase of the MAP kinase subfamily ser/thr kinases; pmk-1 encodes a mitogen-activated protein kinase (MAPK), orthologous to human p38 MAPK (OMIM:600289), that is required for eliciting gonadal programmed cell death in response to Salmonella enterica infection; PMK-1 lies upstream of CED-9, a negative regulator of apoptosis, in the programmed cell death pathway. B0218.5 B0218.5 Protein containing two protein kinase domains, has low similarity to C. elegans KIN-19, which is a putative casein kinase 1 that regulates polarity of the EMS blastomere ser/thr kinase B0218.6 B0218.6 Member of the C-type lectin family, has similarity to human C-type mannose receptor MRC1, has similarity to D. melanogaster FW (furrowed) B0218.7 B0218.7 Protein of unknown function B0218.8 B0218.8 Member of the C-type lectin family, has similarity to human C-type mannose receptor MRC1 B0222.1 B0222.1 Protein containing a CX module domain, has high similarity to uncharacterized C. elegans F53C3.6 B0222.10 B0222.10 Protein of unknown function B0222.2 B0222.2 Member of the phosphate transporter family, has low similarity to amphotropic murine retrovirus receptor (solute carrier family 20 member 2, human SLC20A2), which is a sodium-dependent phosphate cotransporter that mediates inorganic phosphate transport phosphate permease B0222.3 B0222.3 Member of the phosphate transporter family, has moderate similarity to sodium inorganic phosphate cotransporter (solute carrier family 20 member 1, rat Slc20a1), which is a high-affinity sodium-inorganic phosphate cotransporter phosphate permease B0222.4 B0222.4 Protein containing two pyridoxal-dependent group II decarboxylase conserved domains, which bind pyridoxal-phosphate groups, has moderate similarity to sphingosine phosphate lyase 1 (mouse Sgpl1), which cleaves the C2-3 carbon of sphingosine phosphate glutamate decarboxylase B0222.5 B0222.5 Protein containing a thyroglobulin type-1 repeat, which may be involved in the control of proteolytic degradation, and a kunitz or bovine pancreatic trypsin inhibitor domain B0222.6 B0222.6 Protein containing two collagen triple helix repeats, which are found in some extracellular proteins, and a nematode cuticle collagen N-terminal domain, has moderate similarity to a region of C. elegans BLI-1 B0222.7 B0222.7 Protein containing two collagen triple helix repeats, which are found in some extracellular proteins, and a nematode cuticle collagen N-terminal domain, has high similarity to a region of C. elegans BLI-1 B0222.8 col-10;B0222.8 Putative collagen B0222.9 B0222.9 Protein containing one molybdopterin binding, one [2Fe-2S] binding, one a-b hammerhead, and one 2Fe-2S iron-sulfur cluster binding domain, has low similarity to xanthine dehydrogenase (rat Xdh), which converts xanthine to uric acid in purine catabolism xanthine dehydrogenase B0228.1 B0228.1 Protein of unknown function B0228.2 B0228.2 Protein of unknown function, has a region of low similarity to a region of copine III (human CPNE3), which has protein kinase activity and may play a role in membrane trafficking B0228.3 B0228.3 Putative coiled-coil protein, has weak similarity to C. elegans T06D8.1 protein B0228.4 B0228.4 Putative coiled-coil protein, has weak similarity to human EEA1 (early endosome-associated), has weak similarity to C. elegans F12F3.3, has weak similarity to C. albicans Met3p, ATP sulfurylase B0228.5 B0228.5 Member of the thioredoxin family, which are small enzymes involved in redox reactions, has moderate similarity to thioredoxin (human TXN), which has dithiol-disulfide oxidoreductase activity and promotes neutrophil migration Thioredoxin I; This gene encodes a protein predicted by Eisenberg and coworkers, with 52% accuracy, to be mitochondrial. B0228.6 B0228.6 Protein of unknown function B0228.7 B0228.7 Protein with high similarity to methylthioadenosine phosphorylase (human MTAP), which catalyzes phosphorolytic cleavage of 5'-methylthioadenosine in purine and methionine salvage pathways, member of the purine phosphorylases family 2 B0228.8 B0228.8 Protein of unknown function, has weak similarity to C. elegans B0228.9 B0228.9 B0228.9 Protein of unknown function, has weak similarity to C. elegans B0228.8 B0238.1 B0238.1 Member of the carboxylesterase type B family, has low similarity to carboxylesterase 1 (monocyte-macrophage serine esterase 1, rat Ces1), which is a liver esterase carboxylesterase B0238.10 B0238.10 Protein with strong similarity to S. cerevisiae Mak3p, a protein N-acetyltransferase that acetylates the N-terminus of L-A virus GAG protein acyltransfersase B0238.11 B0238.11 Protein of unknown function B0238.12 B0238.12 Protein containing two trypsin inhibitor-like cysteine rich domains, has moderate similarity to uncharacterized C. elegans C25E10.9 B0238.13 B0238.13 Member of the carboxylesterase type B family, has a region of low similarity to carboxylesterase 1 (monocyte-macrophage serine esterase 1, rat Ces1), which is a liver esterase carboxylesterase B0238.3 B0238.3 Protein of unknown function, has high similarity to uncharacterized C. elegans B0238.4 7TM chemoreceptor, srt family B0238.4 B0238.4 Protein of unknown function, has high similarity to uncharacterized C. elegans B0238.3 B0238.5 B0238.5 Protein of unknown function, has high similarity to uncharacterized C. elegans B0238.3 7TM chemoreceptor, srt family B0238.6 B0238.6 Protein of unknown function, has high similarity to uncharacterized C. elegans B0238.8 7TM chemoreceptor, srt family B0238.7 B0238.7 Member of the carboxylesterase type B family, has low similarity to butyrylcholinesterase (mouse Bche) carboxylesterase B0238.8 B0238.8 Protein of unknown function, has high similarity to uncharacterized C. elegans B0238.6 7TM chemoreceptor, srt family B0238.9 B0238.9 Protein of unknown function B0240.1 rhr-2;B0240.1 Member of the ammonium transporter family of membrane transporters, has moderate similarity to rhesus glycoprotein type C (human RHCG), which is an ammonium transporter that is expressed in nonerythroid tissues erythrocyte plasma membrane glycoprotein like; rhr-2 encodes a predicted transmembrane protein with similarity to human Rh blood group antigens proposed to function in inorganic ion transport and metabolism; the role of RHR-2 in C. elegans development or behavior remains unclear, as loss of RHR-2 function via RNA-mediated interference does not result in any abnormalities. B0240.2 B0240.2 Protein of unknown function B0240.3 daf-11;B0240.3 A guanylate cyclase that is involved in chemosensation and dauer formation guanylate cyclase; The daf-11 gene encodes a guanylate cyclase that affects dauer formation, chemotaxis, and axon formation; it is genetically upstream of daf-12 with respect to dauer larvae formation and is expressed in a subset of amphid neurons. B0244.10 B0244.10 Putative ortholog of C. elegans B0244.6 gene product B0244.11 B0244.11 Protein of unknown function B0244.2 ida-1;ia2;B0244.2 Putative receptor-type tyrosine protein phosphatase-like protein, component of neurosecretory cell dense core vesicles, ortholog of human PTPRN and PTPRN2 protein tyrosine phosphatase; ida-1 encodes a protein tyrosine phosphatase-like receptor, orthologous to the mammalian type I diabetes autoantigens IA-2 and phogrin that are expressed in dense core vesicles of neuroendocrine tissue and involved in regulated protein secretion; in C. elegans, IDA-1 appears to be required for regulating presynaptic neurotransmission and in particular, for the neuropeptidergic control of egg-laying; ida-1 interacts genetically with unc-31 and unc-64, which encode proteins required for dense core vesicle fusion and exocytosis; ida-1 expression is detected in a subset of neurons in the anterior nerve ring, the ventral nerve cord, the tail, and the vulva, including the VC vulval motoneurons and the HSN egg-laying neurons; ida-1 is also detected in the vulval uv1 cells, non-neuronal cells that contain neurosecretory-like vesicles. B0244.3 B0244.3 Protein of unknown function B0244.4 B0244.4 Protein with strong similarity to C. elegans B0244.5 gene product B0244.5 B0244.5 Protein with strong similarity to C. elegans B0244.4 gene product B0244.6 B0244.6 Member of the rhodopsin family of G protein-coupled receptors (GPCR) B0244.7 B0244.7 Member of the rhodopsin family of G protein-coupled receptors (GPCR), has weak similarity to uncharacterized C. elegans ZK418.7 B0244.8 B0244.8 Protein containing seven low-density lipoprotein receptor class A domains, has low similarity to a region of low density lipoprotein receptor-related protein 1B (human LRP1B), which is involved in endocytosis and associated with lung cancer LDL receptor B0244.9 B0244.9 Protein of unknown function B0250.1 B0250.1 Protein with high similarity to ribosomal protein L2 (S. cerevisiae Rpl2Bp), which is part of the large ribosomal subunit, member of the ribosomal L2 family Ribosomal Proteins L2; rpl-2 encodes a large ribosomal subunit L8 protein. B0250.2 B0250.2 Protein of unknown function B0250.4 B0250.4 Protein with moderate similarity to C. elegans R07E5.5 gene product B0250.5 B0250.5 Protein with high similarity to 3-hydroxyisobutyrate dehydrogenase (rat HIBADH), which catalyzes the NAD-dependent oxidation of 3-hydroxbutyrate to methylmalonate in valine catabolism 3-HYDROXYISOBUTYRATE DEHYDROGENASE PRECURSOR (EC 1.1.1.31) (HIBADH) (FRAGMENT); This gene encodes a protein predicted by Eisenberg and coworkers, with 52% accuracy, to be mitochondrial. B0250.6 B0250.6 Protein containing a DUF40 domain of unknown function, which contain four conserved cysteines, has high similarity to uncharacterized C. elegans M01B2.3 7TM receptor, srbc family B0250.7 B0250.7 Member of the ribosomal L2 family, which are part of the large ribosomal subunit, has a region of strong similarity to a region of C. elegans B0250.1, which is a protein involved in embryogenesis and morphogenesis Ribosomal Proteins L2 B0250.8 B0250.8 Protein with moderate similarity to C. elegans K09H9.6 gene product B0250.9 B0250.9 Member of the ergosterol biosynthesis family, which includes reductases and anchor proteins, contains a DUF40 domain, which contain four conserved cysteines, has a region of low similarity to 7-dehydrocholesterol reductase (human DHCR7) sterol reductase; B0250.9 is orthologous to the human gene 7-DEHYDROCHOLESTEROL REDUCTASE (DHCR7; OMIM:602858), which when mutated leads to disease. B0252.1 B0252.1 Protein containing a protein kinase domain, has a region of low similarity to a region of C. elegans DAF-2, which is a transcription factor involved in fertilization, gametogenesis, and response to UV Tyrosine-protein kinase B0252.2 asm-1;B0252.2 Acid sphingomyelinase Spingomyelin phosphodiesterase B0252.3 B0252.3 Member of the sugar (and other) transporter family, has low similarity to solute carrier family 22 (organic cation transporter) member 2 (human SLC22A2) B0252.4 cyp-10;B0252.4 Cyclophilin-related peptidylprolyl cis-trans-isomerase Cyclophilin; cyp-10 encodes a divergent cyclophilin isoform that is functional when expressed in E. coli. B0252.5 B0252.5 Protein of unknown function B0252.6 B0252.6 Protein of unknown function, has weak similarity to C. elegans T22B11.1 B0261.1 B0261.1 Protein containing one Myb-like DNA-binding domain B0261.2 Ce-tor;B0261.2 Protein containing two phosphatidylinositol 3- and 4-kinase domains, two FATC (FRAP, ATM, TRRAP C-terminal) domains, and a FAT (FRAP, ATM and TRRAP) domain, has moderate similarity to FK506 binding protein 12-rapamycin associated protein 1 (human FRAP1) kinase; let-363 encodes, by alternative splicing, two large (>2600-residue) proteins with C-terminal similarity to phosphatidylinositol kinase (PIK); LET-363 proteins are orthologous to S. cerevisiae Tor1p and Tor2p and human FRAP1 (OMIM:601231, mammalian target of FKBP12-rapamycin); LET-363 proteins are required for progression through the L3 stage of larval development and are thought to generally stimulate translation of most or all mRNAs ('global translation'); LET-363 activity is also necessary for normal development and physiology of the intestine; LET-363 proteins are expressed ubiquitously, including a maternal contribution to the early embryo. B0261.4 B0261.4 Possible large ribosomal subunit protein B0261.5 B0261.5 Protein of unknown function B0261.6 B0261.6 Protein of unknown function, has similarity to C. elegans TLF B0261.7 B0261.7 Protein of unknown function, has low similarity to uncharacterized C. elegans C36B1.11 B0272.1 B0272.1 Protein with strong similarity to C. elegans MEC-7, which is a beta tubulin expressed specifically in touch receptor neurons, member of the tubulin-FtzA family, which are involved in polymer formation tubulin beta chain B0272.2 B0272.2 Protein with low similarity to membrin (rat Gosr2), which regulates vesicle transport, docking, and fusion, and functions in intracellular transport of proteins between the ER and Golgi B0272.3 B0272.3 Protein with high similarity to short chain L-3-hydroxyacyl-coenzyme A (human HADHSC), which catalyzes the penultimate step in fatty acid beta oxidation, contains 3-hydroxyacyl-CoA dehydrogenase NAD binding domain and C-terminal domains 3-hydroxyacyl-CoA dehydrogenase B0272.4 B0272.4 Member of the enoyl-coA hydratase or isomerase protein family, has moderate similarity to peroxisomal D3,D2-enoyl-CoA isomerase (human PECI), which catalyzes an isomerization step in the beta oxidation of fatty acids enoyl-CoA hydratase/isomerase B0272.5 B0272.5 Protein containing several filamin (ABP120) or Dictyostelium gelation factor (ABP280) repeat domains, which are found in actin-binding proteins, has weak similarity to a region of filamin A (filamin alpha, human FLNA), which mediates actin crosslinking B0273.1 B0273.1 Protein of unknown function, has high similarity to uncharacterized C. elegans B0334.10 B0273.2 puf-7;B0273.2 Protein containing six Pumilio-family (Puf) RNA binding domains, has moderate similarity to a region of C. elegans FBF-2, which is an RNA-binding protein involved in sex determination puf-7 encodes a protein 97% identical to PUF-6 and functions redundantly with the other PUF genes, fbf-1, fbf-2, puf-6, and puf-8, during primordial germ cell development, based on combinatorial RNAi; interacts with NOS-2 in yeast two-hybrid screens. B0273.3 B0273.3 Protein of unknown function, has a region of low similarity to a region of small nuclear RNA activating complex polypeptide 3 50kD (human SNAPC3), which is a DNA binding subunit of SNAPc complex B0273.4 unc-5;B0273.4 Type 1 transmembrane receptor expressed on the surface of axon growth cones and motile mesodermal cells to guide dorsal-specific movement, member of the immunoglobulin superfamily axon guidance protein; The unc-5 gene encodes a netrin receptor required to guide cellular and axonal migrations along the body wall. B0280.1 B0280.1 Protein with high similarity to rat Rabggtb, which is the beta subunit of the geranylgeranyl transferase that transfers geranylgeranyl groups to C-terminal cysteines on Rab proteins, contains fifteen prenyltransferase and squalene oxidase repeat domains prenyltransferase BET2 B0280.10 B0280.10 Protein of unknown function B0280.11 B0280.11 Protein containing a C-terminal KH domain involved in RNA binding, has weak similarity to tyrosine protein phosphatases Tyrosine-phosphatase B0280.12 glr-2;B0280.12 Member of the ligand-gated ion channel protein family Glutamate receptor; glr-2 encodes an AMPA (non-NMDA)-type ionotropic glutamate receptor subunit; GLR-2 activity is required for mediating the behavioral response to light nose touch and for regulating the frequency with which animals change locomotory direction in response to sensory cues such as food; GLR-2 and GLR-1, a second AMPA-type ionotropic glutamate receptor, can interact to form functional heteromeric channels; GLR-2 is expressed in many neurons, including four of the five pairs of command interneurons that are required for locomotory control. B0280.2 B0280.2 Protein containing two wasp homology 1 (WH1) domains B0280.3 B0280.3;nhr-10 Protein with high similarity to ribose 5-phosphate isomerase A (mouse Rpia), which converts ribose 5-phosphate to ribulose 5-phosphate and acts in the pentose phosphate cycle B0280.4 B0280.4 Protein containing three C2H2 type zinc finger domains, which bind nucleic acids, has a region of moderate similarity to a region of zinc finger protein 234 (human ZNF234), which is a Kruppel-related zinc-finger transcriptional corepressor odd-1 encodes a C2H2-type zinc finger-containing transcription factor similar to Drosophila odd skipped which is required for embryonic patterning; ODD-1 is expressed in the gut during embryogenesis and appears to be essential for larval development. B0280.5 B0280.5 Protein containing six chitin binding peritrophin-A domains, has a region of low similarity to a region of C. elegans CEJ-1, which is a possible cell junction protein B0280.5 encodes a protein with a chitin binding peritrophin-A domain that is required, in conjunction with CEJ-1, for early embryonic development; B0280.5 mRNA is expressed specifically in the adult hermaphrodite germ line, is a direct target of GLD-1, and has an RNAi phenotype consistent with the hypothesis that B0280.5 is an effector of GLD-1 in the germline. B0280.7 B0280.7 Protein with moderate similarity to C. elegans F25E2.2 gene product B0280.8 nhr-10;B0280.8 Protein containing a nuclear hormone receptor ligand-binding domain and a C4-type zinc finger domain, which bind DNA and may be involved in transcription regulation, has low similarity to hepatic nuclear factor 4 (mouse Hnf4) retinoic acid; nhr-10 encodes a predicted nuclear hormone receptor diverged from nuclear hormone receptors in other phyla; its mRNA is expressed throughout development with possibly lower expression from the L4 larval to adult stages, and the protein is expressed in neuronal processes. B0280.9 B0280.9 Protein containing three WD domains (WD-40 repeat), which may mediate protein-protein interactions, has low similarity to uncharacterized CGI-48 protein (human LOC51096) B0281.1 B0281.1 Protein with moderate similarity to C. elegans B0281.8 gene product B0281.2 B0281.2 Member of the reverse transcriptase protein family, which are RNA-dependent DNA polymerases, has high similarity to uncharacterized C. elegans B0302.6 B0281.3 B0281.3 Protein of unknown function, has high similarity to uncharacterized C. elegans K09F6.7 B0281.4 B0281.4 Protein containing a K+ channel tetramerization domain, which facilitate assembly of alpha-subunits into functional tetrameric channels, has high similarity to uncharacterized C. elegans B0281.5 B0281.5 B0281.5 Protein containing a K+ channel tetramerization domain, which facilitate assembly of alpha-subunits into functional tetrameric channels, has high similarity to uncharacterized C. elegans C40A11.6 B0281.6 B0281.6 Protein containing a K+ channel tetramerization domain, which facilitate assembly of alpha-subunits into functional tetrameric channels, has high similarity to uncharacterized C. elegans C40A11.7 B0281.8 B0281.8 Protein containing a C3HC4 type Ring zinc finger, which may mediate protein-protein interactions, has high similarity to uncharacterized C. elegans ZK1240.5 B0284.1 B0284.1 Protein of unknown function, has moderate similarity to uncharacterized C. elegans B0284.2 B0284.2 B0284.2 Protein of unknown function, has moderate similarity to uncharacterized C. elegans B0284.4 B0284.3 B0284.3 Protein of unknown function B0284.4 B0284.4 Protein of unknown function, has moderate similarity to uncharacterized C. elegans B0284.2 B0285.1 B0285.1 Protein containing a protein kinase domain, has a region of moderate similarity to cyclin-dependent kinase 9 (CDC2-related kinase, mouse Cdk9), which is a serine-threonine kinase expressed maximally during muscle and neural cell terminal differentiation serine/threonine kinase (CDC2/CDKX subfamily) B0285.10 B0285.10 Member of the choline or ethanolamine kinase family, which catalyze formation of phosphatidylcholine by the CDP-choline pathway, has low similarity to a region of choline-ethanolamine kinase (rat Chkl), which is involved in phosphatidylcholine synthesis choline kinase B0285.3 B0285.3 Protein of unknown function B0285.4 B0285.4 Putative leucine carboxyl methyltransferase, has similarity to human LCMT B0285.5 B0285.5 Protein of unknown function hse-5 encodes a D-glucuronyl C5-epimerase. B0285.6 B0285.6 Member of the Sodium:sulfate symporter family of membrane transporters, has moderate similarity to solute carrier family 13 (sodium-dependent dicarboxylate transporter) member 3 (rat Nadc3), which acts in di- and tri-carboxylic acid transport Yeast ORF YCS7_YEAST B0285.7 B0285.7 Member of the M1 peptidase family of aminopeptidases Aminopeptidase B0285.8 B0285.8 Member of the choline or ethanolamine kinase family, which catalyze the formation of phosphatidylcholine by the CDP-choline pathway, has low similarity to a region of choline kinase (human CHK), which catalyzes the first step in the CDP-choline pathway choline kinase B0285.9 B0285.9 Member of the choline or ethanolamine kinase family, which catalyze the formation of phosphatidylcholine by the CDP-choline pathway, has low similarity to choline-ethanolamine kinase (rat Chkl), which is involved in phosphatidylcholine biosynthesis choline kinase B0286.1 B0286.1 Protein of unknown function B0286.2 B0286.2 Protein with similarity to a human leukocyte transmembrane protein, CD97beta, member of the C-type lectin family lat-2 encodes a predicted transmembrane protein that is homologous to vertebrate latrophilins, alpha-latrotoxin binding proteins that are members of the Class B/secretin family of G protein-coupled receptors; by homology, LAT-2 is predicted to function as a peptide hormone receptor that couples ligand binding to heterotrimeric G protein-mediated stimulation of secretion; lat-2 is expressed in the g1 gland cells and in the arcade cells in the head, and its expression has been reported to cycle with larval molts; as loss of lat-2 activity via large-scale RNAi screens does not result in any obvious abnormalities, the precise role of LAT-2 in C. elegans development and/or behavior is not yet known. B0286.3 B0286.3 Member of 1-(5-phosphoribosyl)-5-amino-4-imidazole-carboxylate (AIR) carboxylase and SAICAR (phosphoribosylaminoimidazole-succinocarboxamide) synthetase families, has high similarity to uncharacterized SAICAR synthetase and AIR carboxylase (rat Ade2h1) saicar synthetase/air carboxlyase; This gene encodes a protein predicted by Eisenberg and coworkers, with 52% accuracy, to be mitochondrial. B0286.4 B0286.4 Protein of unknown function, has moderate similarity to a region of carbon catabolite repressor negative regulator of transcription complex subunit 2 (human CNOT2), which is a component of the CCR4-NOT global transcriptional regulator complex B0286.5 B0286.5 Protein containing a fork head domain, which are found in transcription factors involved in cell fate determination, has a region of moderate similarity to a region of forkhead box I1 (human FOXI1), which is a transcriptional activator fork head DNA-binding protein; fkh-6 encodes a protein which belongs to the forkhead family of transcription factors; fkh-6 is required for several aspects of male gonadogenesis including asymmetric cell division, cell migration and sex determination and appears to act downstream of tra-1; FKH-6 is specifically expressed in the gonad. B0294.1 B0294.1 Protein of unknown function, has high similarity to uncharacterized C. elegans C12D5.3 B0294.2 B0294.2 Protein with strong similarity to C. elegans B0294.1 gene product B0294.3 B0294.3 Protein of unknown function, has moderate similarity to C. elegans T28A11.21 This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins. B0302.1 kin-25;Cehd-20;B0302.1 Putative tyrosine protein kinase, has similarity to human p21cdc42 protein kinase that inhibits p21cdc42, has similarity to D. melanogaster SRC-related proteins protein tyrosine kinase; Expression experimentally verified by RT-PCR. B0302.2 B0302.2 Protein of unknown function B0302.3 B0302.3 Member of the reverse transcriptase protein family, which are RNA-dependent DNA polymerases, has very strong similarity to uncharacterized C. elegans T06C10.5 reverse transcriptase B0302.4 B0302.4 Protein of unknown function B0302.5 B0302.5 Protein of unknown function tyrosine-protein kinase B0302.6 B0302.6 Member of the reverse transcriptase protein family, which are RNA-dependent DNA polymerases, has high similarity to uncharacterized C. elegans F22B3.3 reverse transcriptase B0303.11 B0303.11 Protein with moderate similarity to human sodium/potassium/chloride transporters B0303.14 B0303.14 Protein of unknown function Giant secretory protein I-C B0303.15 B0303.15 Protein containing a ribosomal L11 domain, which are present in the large ribosomal subunit, has low similarity to S. cerevisiae Mrpl19p, which is a mitochondrial ribosomal protein of the large subunit Ribosomal protein L11; This gene encodes a protein predicted by Eisenberg and coworkers, with 52% accuracy, to be mitochondrial. B0303.2 B0303.2 Member of the NNMT, PNMT or TEMT family of methyltransferases, has low similarity to nicotinamide N-methyltransferase (human NNMT), which transfers S-adenosyl L-methionine methyl groups to nicotinamide, pyridines, structurally-related drugs, xenobiotics B0303.3 B0303.3 Protein with high similarity to 3-hydroxyacyl-CoA dehydrogenase (human HADHB), which is the 3-ketoacyl-CoA thiolase trifunctional protein beta subunit that is involved in fatty acid beta-oxidation, contains thiolase N-terminal and C-terminal domains Acetyl-coa acetyltransferase; B0303.3 is orthologous to the human gene 3-KETOACYL-COA THIOLASE BETA-SUBUNIT OF TRIFUNCTIONAL PROTEIN (HADHB; OMIM:143450), which when mutated leads to disease. B0303.4 B0303.4 Member of the ubiquitin family B0303.5 B0303.5 Member of the Tc3 Transposase protein family transposase B0303.7 B0303.7 Protein containing three Src homology 3 (SH3) domains, which bind proline-rich peptides, has a region of low similarity to a region of arg binding protein 2 (human ARGBP2), which may act as a cytoskeletal adaptor protein Neutrophil oxidase factor B0303.8 B0303.8 Protein of unknown function, has weak similarity to C. elegans T11A5.5 B0303.9 slp-1;B0303.9 Member of the Sec1 family, which may be involved in secretion, has low similarity to vacuolar sorting protein 33a (rat Vps33a) SLP-1 B0304.1 hlh-1;CeMyoD;B0304.1 Protein involved in specification of muscle cell fates; member of the Helix-loop-helix DNA-binding Domain protein family helix-loop-helix transcription factor; hlh-1 is orthologous to the human gene MYOGENIC FACTOR 6 (HERCULIN) (MYF6; OMIM:159991), which when mutated leads to disease. B0304.2 B0304.2 Protein of unknown function B0304.3 B0304.3 Member of the cytochrome P450 family, has low similarity to cytochrome P450 subfamily IIJ5 (mouse Cyp2j5), which is a heme-thiolate protein involved in the catalysis of NADPH-dependent oxidation of arachidonic acid to eicosanoids Cytochrome P450; The B0304.3 gene encodes a homolog of the human gene CYP7B1, which when mutated leads to giant cell hepatitis (OMIM:231100). B0304.4 B0304.4 Protein of unknown function B0304.5 B0304.5 Member of C. elegans Sra integral membrane protein family, which contain 6-7 hydrophobic, putative transmembrane, regions 7TM chemoreceptor, sra family B0304.6 B0304.6 Member of C. elegans Sra integral membrane protein family, which contain 6-7 hydrophobic, putative transmembrane, regions, has low similarity to uncharacterized C. elegans SRA-10 7TM chemoreceptor, sra family B0304.7 B0304.7 Member of C. elegans Sra integral membrane protein family, which contain 6-7 hydrophobic, putative transmembrane, regions 7TM chemoreceptor, sra family B0310.1 B0310.1 Protein with weak similarity to calcium channel proteins, has weak similarity to human KCNK1 and KCNK5, has weak similarity to C. elegans TWK-3 B0310.2 B0310.2 Protein containing two C2H2 type zinc finger domains, which bind nucleic acids, has a region of moderate similarity to a region of KRAB zinc finger suppressor protein 1 (rat Rn.11374), which acts as a transcriptional repressor C2H2-type zinc fingers B0310.3 B0310.3 Protein of unknown function B0310.4 B0310.4 Protein of unknown function, has high similarity to uncharacterized C. elegans Y54B9A.1 repetitive proline-rich cell wall protein B0310.5 B0310.5 Protein containing two UDP-glucoronosyl and UDP-glucosyl transferase domains, which transfer glycosyl groups to small hydrophobic molecules, has weak similarity to UDP glycosyltransferase 1 A3 (human UGT1A3), which plays a role in drug metabolism UDP galactosyltransferase B0310.6 B0310.6 Protein of unknown function B0331.1 B0331.1 Member of the cytochrome P450 family, has low similarity to cytochrome P450 subfamily 4A polypeptide 11 fatty acid omega-hydroxylase (rat Cyp4a11), which hydroxylates steroids, fatty acids, and xenobiotics and is involved in blood pressure regulation cytochrome P450 B0331.2 B0331.2 Member of the phosphate transporter family, has weak similarity to sodium inorganic phosphate cotransporter (solute carrier family 20 member 1, rat Slc20a1), which is a high-affinity sodium-inorganic phosphate cotransporter phosphate permease like B0334.1 B0334.1 Member of the transthyretin-like family, has high similarity to uncharacterized C. elegans R90.2 Transthyretin-like family B0334.10 B0334.10 Protein of unknown function, has high similarity to uncharacterized C. elegans B0273.1 B0334.11 ooc-3;B0334.11 Protein involved in the establishment of cell and embryonic polarity and morphogenesis ooc-3 encodes a nematode-specific protein with a predicted signal sequence, four predicted transmembrane domains, and two putative PEST sequences; OOC-3 is probably localized to the endoplasmic reticulum (ER), and is maternally required for correct localization of PAR-2 and PAR-3 in the P1 blastomere of the two-cell stage embryo; specifically, OOC-3 is required for restricting PAR-3 to the anterior cortex of the P1 blastomere to assure PAR-2 localization at the posterior cortex; more generally, OOC-3 is required to establish asymmetrical anterior-posterior cortical domains and spindle orientation in P1. B0334.2 twk-1;B0334.2 Member of the 4 TM potassium channel protein family potassium channel protein; twk-5 encodes one of 44 C. elegans TWK (two-P domain K+) potassium channel subunits that contain two pore-forming domains and four transmembrane domains; as loss of TWK-5 function via RNA-mediated interference (RNAi) does not result in any abnormalities, the precise role of TWK-5 in C. elegans development and/or behavior is not yet known; TWK-5 may, however, function redundantly with other TWK channels; the TWK-5 expression pattern is not yet known. B0334.3 B0334.3;B0334.3 Member of the decarboxylase (tentative) protein family Thiamine pyrophosphate enzymes B0334.4 B0334.4 Protein of unknown function, has low similarity to uncharacterized PX19-like protein (human PX19), which may have a role in B lymphocyte development and is predominantly expressed in germinal centers Yeast hypothetical protein L8167.12 like B0334.5 B0334.5 Protein of unknown function phytoene synthase precursor B0334.6 B0334.6 Member of the rhodopsin family of G protein-coupled receptors (GPCR) Gonadotropin-releasing hormone receptor like protein B0334.7 B0334.7 Member of the 7-transmembrane chemoreceptor family of G protein-coupled receptors (GPCR), has low similarity to uncharacterized C. elegans W02H5.6 B0334.8 age-1;daf-23;B0334.8 Signal transduction protein of the phosphatidylinositol-3-OH kinase (PI(3)K) family; involved in control of multiple processes including dauer larva formation, longevity, fertility, thermotolerance, and adult motility phosphatidylinositol 3-kinase; age-1 encodes the C. elegans ortholog of the phosphatidylinositol-3-kinase p110 catalytic subunit; AGE-1, supplied maternally and embryonically, is a central component of the C. elegans insulin-like signaling pathway, lying downstream of the DAF-2/insulin receptor and upstream of both the PDK-1 and AKT-1/AKT-2 kinases and the DAF-16 forkhead type transcription factor, whose negative regulation is the key output of the insulin signaling pathway; in accordance with its role in insulin signaling, AGE-1 activity is required for regulation of metabolism, life span, dauer formation, stress resistance, fertility, and embryonic development; although the age-1 expression pattern has not yet been reported, ectopic expression studies indicate that pan-neuronal age-1 expression is sufficient to rescue life-span defects, while neuronal, intestinal, or muscle expression can partially rescue dauer formation, and neuronal or muscle expression can rescue metabolic defects. B0334.9 B0334.9 Protein with strong similarity to C. elegans F16B12.6 gene product B0336.1 wrm-1;B0336.1 Beta-catenin-related protein required for establishment of embryonic polarity; member of a divergent Wnt signaling pathway B0336.10 B0336.10 Protein with high similarity to ribosomal protein L23 (S. cerevisiae Rpl23bp), which is a structural ribosomal protein, member of the ribosomal L14p or L23e family, which are part of the large ribosomal subunit and may bind rRNA rpl-23 encodes a large ribosomal subunit L23 protein. B0336.11 B0336.11 Protein containing a major sperm protein (MSP) domain, which are involved in sperm motility B0336.12 B0336.12 Protein of unknown function B0336.13 B0336.13 Protein with strong similarity to C. elegans Y111B2A.13 gene product B0336.2 arf-1;B0336.2 Protein with strong similarity to ADP-ribosylation factor 1 (human ARF1), which is a small guanine nucleotide-binding protein that plays a role in vesicular transport, member of the ADP-ribosylation factor (ARF) family ARF; arf-1 encodes an ADP-ribosylation factor homolog required in vivo for embryonic development, fertility, locomotion, vulval development, and cuticular synthesis; ARF proteins are N-myristoylated GTPases that regulate membrane traffic and the actin cytoskeleton, and that activate both phospholipase D1 (PLD1) and phosphatidylinositol 4-phosphate 5-kinase. B0336.3 B0336.3 Protein containing a CCCH-type zinc finger domain, which bind DNA or RNA B0336.4 rgs-5;B0336.4 Protein of unknown function, has a region of low similarity to a kinase anchor protein 10 (mouse Akap10), which interacts with type I and type II regulatory subunits of cAMP-dependent protein kinase and anchors the kinase near its physiological substrates rgs-5 encodes a regulator of G protein signaling; by homology, RGS-5 is predicted to function as a GTPase-activating protein that binds G protein alpha subunits and negatively regulates heterotrimeric G protein signaling; loss of rgs-5 activity via RNAi or a deletion mutation results in no obvious defects, and likewise, rgs-5 overexpression has no measurable effect on egg-laying behavior, locomotion, or viability; an rgs-5 transcriptional reporter is expressed in head neurons in larvae and adults. B0336.5 B0336.5 Member of the TFIIA small subunit protein family B0336.6 B0336.6 Protein containing a Src homology 3 (SH3) domain, has moderate similarity to spectrin SH3 domain binding protein 1 (human SSH3BP1), which interacts with the SH3 domains of human EPS8, human ABL1, and spectrin (human SPTA1) and is involved in endocytosis B0336.6 encodes an Abl interactor ortholog, with an SH3 domain, required for embryonic development; mammalian Abl interactors are associated with synaptosomes, growth cone particles, and macropinocytic vesicles, and may regulate Rac-dependent cytoskeletal reorganization and Abl kinase activity; B0336.6's orthologs include human SSH3BP1 (ABI1; OMIM:603050, mutated in acute myeloid leukemia), ABI-2 (OMIM:606442), and NESH (OMIM:606363); B0336.6 binds UNC-53 in two-hybrid screens. B0336.7 B0336.7 Protein of unknown function B0336.8 B0336.8 Protein of unknown function, has low similarity to uncharacterized autophagy 12-like (human APG12L) lgg-3 encodes a hydrophilic protein that is orthologous to Saccharomyces cerevisiae autophagy protein Apg12p; by homology, LGG-3 is predicted to function as a modifier protein required for a protein conjugation system essential for autophagy; in the context of this conjugation system, LGG-3 is predicted to interact with Apg7p and Apg5p homologs (encoded by M7.5 and Y71G12B.12a, respectively) to effect bulk degradation of cytoplasmic components under conditions of starvation or cellular remodeling; free LGG-3 is predicted to localize to the cytoplasm, while LGG-3 conjugated to the Apg5p homolog is predicted to associate with membrane compartments; loss of lgg-3 activity via large-scale RNAi screens results in no obvious developmental or behavioral abnormalities. B0336.9 swp-1;CeSWAP;B0336.9 Putative splicing regulator and member of the SWAP protein family swp-1 encodes a protein containing two SWAP (Suppressor-of-White-APricot splicing regulator) domains that have been implicated in RNA binding; orthologous to C. briggsae CBG09000. B0344.2 B0344.2 Protein with strong similarity to C. elegans wrt-1 gene product B0348.1 B0348.1 Protein of unknown function, has moderate similarity to uncharacterized C. elegans Y37D8A.8 B0348.2 B0348.2 Protein with strong similarity to C. elegans B0348.1 gene product B0348.3 egl-8;pbo-2;B0348.4;B0348.3 Putative phosphatidylinositol phospholipase C B0348.5 B0348.5 Putative ortholog of C. elegans Y108G3B.A gene product B0348.6 ife-3;B0348.6 Translation initiation factor eIF4E, binds to mRNA cap structure translation initiation factor; ife-3 encodes one of five C. elegans homologs of the mRNA cap-binding protein eIF4E; by homology, IFE-3 is predicted to bind capped mRNA and mediate its recruitment to ribosomes during translation initiation; in vitro, IFE-3 binds a monomethylated guanosine cap structure but does not bind a trimethylated guanosine cap, which suggests that IFE-3 likely mediates translation of those mRNAs that do not contain a spliced-leader sequence; of the C. elegans eIF4E isoforms, IFE-3 is the most similar to human eIF4E and is the only isoform required for viability (homozygous ife-3 mutant embryos arrest in the early division stages of embryogenesis); IFE-3 is enriched in the adult gonad. B0350.1 B0350.1 Protein of unknown function, has weak similarity to uncharacterized C. elegans Y2C2A.1 B0350.2 unc-44;A013;B0350.2 Set of ankyrin-related proteins generated by alternate splicing, required for axonal guidance and proper axon fasciculation AO49 ankyrin; The unc-44 gene encodes an ankyrin-like protein required for proper sex myoblast and axonal guidance during development. B0350.3 B0350.3 Protein of unknown function B0353.1 B0353.1 Protein of unknown function B0361.10 B0361.8;B0361.10 Member of the glycosyl transferase group 1 protein family synaptobrevin B0361.2 B0361.2 Putative ortholog of C. elegans B0361.1 gene product B0361.3 B0361.3 Member of the sugar (and other) transporter family, has a region of weak similarity to solute carrier family 22 (organic cation transporter) member 2 (rat Slc22a2) B0361.4 B0361.4 Protein of unknown function B0361.5 B0361.5 Member of the phosphatidylserine decarboxylase family, which are involved in aminophospholipid biosynthesis, has low similarity to phosphatidylserine decarboxylase (S. cerevisiae Psd1p), which converts phosphatidyl-L-serine to phosphatidylethanolamine Phosphatidylserine decarboxylase B0361.6 B0361.6 Protein containing one uncharacterized ACR domain, has low similarity to uncharacterized human HSPC109 B0361.7 B0361.7 Member of the histidine acid phosphatase protein family, which hydrolyze phosphate esters at low pH, has low similarity to lysosomal acid phosphatase (rat Acp2), which is a tartrate-inhibitable lysosomal enzyme Acid phosphatase B0361.9 B0361.9 Protein containing a PAN domain, which may mediate protein-protein or protein-carbohydrate interactions B0365.1 B0365.1 Protein with high similarity to ATP citrate lyase (human ACLY), which catalyzes formation of acetyl-CoA and oxaloacetate in cholesterol and fatty acid synthesis, member of the ATP-citrate lyase or succinyl-CoA ligase family, contains a CoA binding domain ATP citrate lyase; This gene encodes a protein predicted by Eisenberg and coworkers, with 52% accuracy, to be mitochondrial. B0365.2 B0365.2 Member of the 7-transmembrane chemoreceptor family of G protein-coupled receptors (GPCR), has low similarity to C. elegans ODR-10, which is a G protein-coupled receptor involved in odorant response B0365.3 eat-6;spa-1;B0365.3 Sodium, potassium ATPase, alpha subunit; a P-type ATPase Na(+)/K(+) ATPase alpha subunit; eat-6 encodes an ortholog of the alpha subunit of a sodium/potassium ATPase, which in turn affects Na+,K(+)-ATPase activity of membranes by affecting the level of the phosphorylated intermediate of the Na+,K(+)-ATPase; EAT-6 affects relaxation of the pharyngeal muscles, fertility (and thus affects feeding); EAT-6 also affects body length, life span, and ASE, ASI and ASJ axonal outgrowth. B0365.5 B0365.5 Member of the C-type lectin family C-type lectin domain B0365.6 B0365.6 Member of the C-type lectin protein family C-type lectin domain B0365.7 B0365.7 Protein of unknown function, has weak similarity to uncharacterized dynein axonemal heavy chain 7 (human DNAH7) dynein B0379.1 B0379.1 Protein of unknown function B0379.2 B0379.2 Protein of unknown function, has very strong similarity to uncharacterized C. elegans Y106G6E.3 B0379.3 B0379.3 Protein of unknown function, has similarity over a small region of the C-terminus to S. cerevisiae Pan1p and to several uncharacterized C. elegans proteins mut-16 encodes a glutamine/asparagine (Q/N)-rich domain-containing protein that lacks obvious homologs outside of other nematode species; MUT-16 activity is required for RNA-mediated interference (RNAi), transgene silencing in germ-line and somatic tissues, and for maintaining low levels of transposon mobilization; MUT-16 is thus predicted to play a role in chromatin organizataion and/or regulation of gene expression. B0379.4 B0379.4 Member of the NLI interacting factor family, has high similarity to a region of S. cerevisiae Psr2p, which is a plasma membrane phosphatase required for sodium stress response B0379.5 B0379.5 Protein of unknown function B0379.6 B0379.6 Protein of unknown function B0379.7 B0379.7 Protein of unknown function, has high similarity to uncharacterized C. elegans B0205.10 B0391.1 B0391.1 Member of the 7-transmembrane chemoreceptor family of G protein-coupled receptors (GPCR), has high similarity to uncharacterized C. elegans Y102A5C.28 B0391.10 B0391.10 Protein with strong similarity to C. elegans Y73B3A.V gene product B0391.11 B0391.11 Protein of unknown function, putative paralog of C. elegans B0391.6 F-box protein B0391.3 B0391.3 Member of the 7-transmembrane chemoreceptor family of G protein-coupled receptors (GPCR), has high similarity to uncharacterized C. elegans F20E11.4 B0391.4 B0391.4 Member of the 7-transmembrane chemoreceptor family of G protein-coupled receptors (GPCR) B0391.5 B0391.5 Protein containing an F-box domain, which serve as a link between a target protein and a ubiquitin-conjugating enzyme, and a DUF38 domain of unknown function, has low similarity to C. elegans FOG-2, which is required for the sexual identity of germ cells F-box protein B0391.6 B0391.6 Protein containing four F-box domains, which serve as a link between a target protein and a ubiquitin-conjugating enzyme, and five DUF38 domains of unknown function, has a region of low similarity to C. elegans FOG-2 F-box protein; This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins; this gene's encoded protein also contains an FTH/DUF38 motif, which may also mediate protein-protein interaction. B0391.7 B0391.7 Protein of unknown function B0391.9 B0391.9 Protein containing a DUF38 domain of unknown function B0393.1 B0393.1 Member of the ribosomal protein S0 protein family 40S ribosomal protein; rps-0 encodes a small ribosomal subunit SA protein that appears to function as both a ribosomal component and a laminin receptor; by homology, RPS-0 is predicted to play roles in protein biosynthesis and cell adhesion; in C. elegans, RPS-0 activity is required for embryonic and germline development, vulval morphogenesis, and the overall health of the animal. B0393.2 B0393.2 Protein containing a TBC domain, which may be GTPase activators of Rab-like small GTPases, has low similarity to uncharacterized human KIAA0210 Probable rabGAP domains B0393.3 B0393.3 Contains an F-box domain, which serve as a link between a target protein and a ubiquitin-conjugating enzyme Leucine Rich Repeat (2 copies) (2 domains) B0393.4 B0393.4 Protein of unknown function B0393.5 B0393.5 Protein containing five epidermal growth factor (EGF)-like domains, has weak similarity to a region of fibrillin-1 (human FBN1), which is an extracellular matrix protein associated with Marfan Syndrome, Shprintzen-Goldberg syndrome, and ectopia lentis EGF-like aspartic acid and asparagine hydroxylation sites B0393.6 B0393.6 Protein with weak similarity to C. elegans T20F5.6 gene product Zinc finger, C3HC4 type (RING finger) B0393.7 B0393.7 Protein containing three low-density lipoprotein receptor class A domains, has a region of low similarity to a region of low density lipoprotein receptor-related protein 2 (glycoprotein 330, human LRP2) LDL receptor ligand-binding repeat bearing protein B0393.8 B0393.8 Protein of unknown function, putative paralog of C. elegans F22D6.14 B0395.1 B0395.1 Member of the sodium or hydrogen exchanger family, which control pH in actively metabolizing cells, has moderate similarity to a region of sodium-hydrogen exchanger 1 (rat Slc9a1), which is an antiporter involved in pH, cell volume, and cell shape control Sodium/Proton antiporter; nhx-1 encodes a sodium/proton exchanger expressed intracellularly within hypodermal and muscle cells; NHX-1 is required for embryonic viability, and is thought to prevent intracellular acidification by catalysing the electroneutral exchange of vesicular sodium for an intracellular proton. B0395.2 B0395.2;ACAT Member of the sterol O-acyltransferase family, which are involved in cholesterol esterification, has moderate similarity to acyl-Coenzyme A:cholesterol acyltransferase (mouse Soat1), which acts in lipoprotein metabolism and cholesterol homeostasis Sterol O-acyltransferase B0395.3 B0395.3 Member of the choline or carnitine O-acyltransferase family, has low similarity to choline acetyltransferase (human CHAT), which synthesizes acetylcholine in neurons and shows decreased activity in Alzheimer's Disease choline O-acetyltransferase; B0395.3 is orthologous to the human gene CHOLINE ACETYLTRANSFERASE ISOFORM R (CHAT; OMIM:118490), which when mutated leads to disease. B0399.A B0399.1;B0399.A Protein containing a calmodulin binding domain, has a region of moderate similarity to Ca2+-activated small-intermediate conductance K+ channel 3 (rat Kcnn3), which is a voltage-independent, apamin-sensitive K+ channel B0403.1 B0403.1 Protein of unknown function, has a region of strong similarity to a region of C. elegans ASP-2, which is an aspartyl protease B0403.2 B0403.2 Member of the ubiquitin-conjugating enzyme (E2) family, which catalyze the covalent attachment of ubiquitin to target proteins, has a region of low similarity to a region of baculoviral IAP repeat-containing 6 (human BIRC6) ubiquitin-conjugating enzyme B0403.3 B0403.3 Putative ortholog of C. elegans B0404.3 gene product B0403.4 B0403.4 Protein with high similarity to protein disulfide isomerase-related protein (rat Rn.2685), which catalyzes disulfide isomerization and the formation of disulfide bonds during protein folding, member of the thioredoxin family protein disulfide-isomerase; This gene encodes a protein predicted by Eisenberg and coworkers, with 52% accuracy, to be mitochondrial. B0410.1 B0410.1 Protein of unknown function B0410.2 B0410.2 Protein of unknown function, has low similarity to uncharacterized mouse Ltap B0410.3 B0410.3 Protein of unknown function B0412.1 B0412.1 Member of the SKI, SNO or DAC family, which are involved in proliferation or development, has a region of moderate similarity to a region of dachshund 1 (Drosophila) homolog (mouse Dach1), which may play a role in neurogenesis and cell-fate determination yeast NUD1 protein B0412.2 daf-7;B0412.2 Ligand that negatively regulates dauer larva development by transduction of chemosensory signals from amphidial neurons ASI, ADF and ASG, member of the TGF-beta superfamily transforming growth factor beta proteins; daf-7 encodes a member of the transforming growth factor beta superfamily that affects dauer larvae formation in a TGF-beta-mediated pathway and also affects egg laying; expressed in the ASI neurons. B0412.3 B0412.3 Protein of unknown function B0412.4 B0412.4 Member of the ribosomal protein S29 protein family 40S ribosomal protein S29; rps-29 encodes a small ribosomal subunit S29 protein; by homology, RPS-29 is predicted to function in protein biosynthesis; in C. elegans, RPS-29 activity is broadly required for embryonic and germline development, normal body coloration and morphology, normal postembryonic growth rates, and the overall health of the animal. B0412.5 B0412.5 Protein of unknown function B0414.1 B0414.1 Protein containing a DUF216 domain of unknown function, has low similarity to uncharacterized C. elegans C08F11.9 7TM chemoreceptor, srz family B0414.2 rnt-1;run;B0414.2 Putative member of PEBP2/CBF family of DNA binding transcription factors rnt-1 is homologous to RUNT and LOZENGE in Drosophila melanogaster, and to human RUNX1 (AML1, OMIM:151385, mutated in familial platelet disorder and acute myeloid leukemia), RUNX2 (OMIM:600211, mutated in cleidocranial dysplasia), and RUNX3 (OMIM:600210). B0414.3 B0414.3 Protein with high similarity to histone H1 (C. elegans H1.4), which is involved in gametogenesis, member of the histone H1 and H5 family of linker histones histone H1 B0414.4 B0414.4 Protein containing a leucine rich repeat C-terminal cysteine rich domain B0414.5 cpb-3;B0414.5 Protein of unknown function, has a region of moderate similarity to a region of cytoplasmic polyadenylation element binding protein (mouse Cpeb), which is a sequence-specific RNA binding protein that regulates cytoplasmic polyadenylation RNA binding protein; The cbp-3 gene encodes a cytoplasmic polyadenylation element binding (CPEB) protein homolog. B0414.6 glh-3;B0414.6 RNA helicase in the germ line and a component of P granules; putative ortholog of S. cerevisiae DBP1 gene product, an ATP-dependent RNA helicase of the DEAD box family RNA helicase; glh-3 encodes a predicted DEAD-like RNA helicase; GLH-3 interacts with itself and with CSN-5, KGB-1, ZYX-1, and GLH-1 in vitro, and is expressed in association with P granules throughout development. B0414.7 B0414.7 Serine/threonine protein kinase of the MAP kinase kinase (MEK kinase) subfamily, has similarity to S. cerevisiae Ssk2p and Ssk22p protein kinase B0414.8 B0414.8 Protein of unknown function B0416.1 B0416.1 Protein of unknown function, has moderate similarity to uncharacterized C. elegans T13G4.3 B0416.2 B0416.2 Protein of unknown function, has high similarity to uncharacterized C. elegans ZK856.6 B0416.3 B0416.3 Protein of unknown function B0416.4 B0416.4 Protein containing a C3HC4 type RING zinc finger, which may mediate protein-protein interactions, has low similarity to uncharacterized C. elegans F53F8.3 B0416.5 B0416.5 Member of an uncharacterized protein family B0416.6 gly-13;B0416.6 N-acetylglucosaminyltransferase I alpha-1,3-mannosyl-glycoprotein beta-1,2-n-acetyglucosaminyltransferase B0416.7 B0416.7 Protein of unknown function, has weak similarity to C. elegans K04F1.8 B0432.1 B0432.1 Protein of unknown function B0432.10 B0432.10 Protein of unknown function B0432.11 B0432.11 Protein of unknown function, has high similarity to uncharacterized C. elegans K07H8.7 B0432.12 B0432.12 Member of the C-type lectin family, has weak similarity to human receptor for C1q/MBL/SPA C-type lectins B0432.13 B0432.13 Protein with weak similarity to C. elegans H10E21.5 gene product B0432.2 B0432.2 Protein with high similarity to RNA-binding protein regulatory subunit (rat Dj1),which may regulate RNA-protein interactions and play a role in fertilization, member of the ThiJ-PfpI family B0432.3 B0432.3 Protein of unknown function B0432.4 B0432.4 Member of the mitochondrial carrier protein family of membrane transporters, has moderate similarity to dicarboxylate carrier protein (C. elegans K11G12.5) mitochrondrial 2-oxoglutarate/malate carrier protein B0432.5 cat-2;B0432.5 Putative tyrosine hydroxylase aromatic amino acid hydroxlase; cat-2 encodes a putative tyrosine hydroxylase that affects dopamine levels that in turn affect locomotory slowing in response to food; expressed in dopamanergic as well as other neurons, male spicules, and male ray neurons. B0432.6 B0432.6 Putative coiled-coil protein, has weak similarity to human myosin heavy chains B0432.7 B0432.7 Protein of unknown function B0432.8 B0432.8 Member of the TatD-related DNase family This gene encodes a protein predicted by Eisenberg and coworkers, with 52% accuracy, to be mitochondrial. B0432.9 B0432.9 Protein containing a C3HC4 type RING zinc finger, which may mediate protein-protein interactions zinc finger protein B0454.1 B0454.1 Protein of unknown function, has moderate similarity to uncharacterized C. elegans B0454.9 B0454.10 B0454.10 Putative ortholog of C. elegans B0454.2 gene product 7TM chemoreceptor, sri family B0454.2 B0454.2 Member of the 7-transmembrane chemoreceptor family of G protein-coupled receptors (GPCR), has high similarity to uncharacterized C. elegans B0454.10 7TM chemoreceptor, sri family B0454.3 B0454.3 Member of the 7-transmembrane chemoreceptor family of G protein-coupled receptors (GPCR), has high similarity to uncharacterized C. elegans B0454.4 7TM chemoreceptor, sri family B0454.4 B0454.4 Member of the 7-transmembrane chemoreceptor family of G protein-coupled receptors (GPCR), has high similarity to uncharacterized C. elegans B0454.10 7TM chemoreceptor, sri family B0454.5 B0454.5 Protein of unknown function B0454.6 B0454.6 Member of the amino acid permease family of membrane transporters, has moderate similarity to solute carrier family 7 member 4 (human SLC7A4), which mediates the uptake of cationic amino acids such as arginine amino acid permease B0454.7 B0454.7 Member of the C-type lectin protein family B0454.8 B0454.8 Protein containing five DUF225 domains of unknown function, has high similarity to uncharacterized C. elegans B0554.2 B0454.9 B0454.9 Protein of unknown function, has moderate similarity to uncharacterized C. elegans B0454.1 B0457.1 B0457.1 Protein with similarity to a human leukocyte transmembrane protein, CD97beta G-protein coupled receptor protein; lat-1 encodes a predicted latrophilin that affects embryonic elongation, pharyngeal development, and reproductive organ formation; apically localized in developing epithelia and localized to presynaptic surfaces in neurons. B0457.2 B0457.2 Protein with moderate similarity to C. elegans C38C6.3 gene product elastin precusor B0457.3 B0457.3 Protein of unknown function, has high similarity to uncharacterized C. elegans B0457.4 B0457.4 B0457.4 Protein of unknown function, has high similarity to uncharacterized C. elegans B0457.3 B0462.1 B0462.1 Protein of unknown function, has weak similarity to uncharacterized C. elegans Y102A5C.4 B0462.2 B0462.2 Member of the 7-transmembrane chemoreceptor family of G protein-coupled receptors (GPCR) B0462.3 B0462.3 Protein of unknown function, has low similarity to uncharacterized C. elegans F55C9.1 B0464.1 B0464.1 Protein with high similarity to aspartyl-tRNA synthetase (human DARS), which associates with a multisynthetase complex, contains an OB-fold nucleic acid binding domain and a class II asparagine, aspartic acid and lysine tRNA synthetase (D, K and N) domain Aspartyl-tRNA synthetase B0464.2 B0464.2 Protein containing eight TPR (tetratrico peptide repeat) domains, which may mediate protein-protein interactions, has moderate similarity to TPR-containing SH2-binding phosphoprotein (mouse Tsbp) TPR Domain B0464.3 B0464.3 Protein of unknown function, has weak similarity to C. elegans C24A3.2 B0464.4 B0464.4 Putative ortholog of D. melanogaster EGH (egghead) protein zw4; bre-3 encodes a protein similar to beta-glycosyltransferases from bacteria that is required for the toxicity of Bacillus thuringiensis Cry5B; BRE-3 may act in a pathway with bre-5 and is expressed and functions in the gut epithelium. B0464.5 spk-1;rsk-1;CeSRPK;B0464.5 Serine/threonine kinase; phosphorylates the RS domain of putative splicing factor SF2 Eukaryotic protein kinase domain; spk-1 encodes a serine/threonine kinase orthologous to the highly conserved serine/arginine-rich protein kinases (SRPKs) that phosphorylate SR proteins, essential components of the pre-mRNA splicing machinery; SPK-1, required for embryogenesis and germline development, can directly bind and phosphorylate RSP-3 (CeSF2/ASF), an SR splicing factor homolog; SPK-1 is expressed predominantly in the adult germline; SPK-1 is homologous to human RSK2, which when mutated leads to Coffin-Lowry syndrome (OMIM:303600). B0464.6 B0464.6 Protein of unknown function B0464.7 pme-1;3J557;B0464.7 Protein with high similarity to breakpoint cluster region protein 1 (barrier autointegration factor, human BCRP1), which is a host cell protein with DNA binding activity, member of the barrier to autointegration factor family barrier-to-autointegration factor; baf-1 encodes a small, novel protein that is highly conserved amongst metazoa; BAF-1 binds double-stranded DNA nonspecifically in vitro and is essential for proper chromosome segregation, embryogenesis, and gonad development in vivo; biochemical and phenotypic analyses suggest that BAF-1 functions as an intramolecular bridge that mediates nuclear assembly and chromatin capture by the reforming nuclear envelope; by homology with mammalian BAF proteins, BAF-1 is also predicted to play a role in regulating gene expression and higher-order chromatin structure; during interphase, BAF-1 colocalizes with LMN-1/lamin to the nuclear envelope and nuclear interior; during mitosis, BAF-1 is present in a more punctate pattern, localizing near condensing chromatin and maintaining this localization through telophase; BAF-1 localization during nuclear assembly requires the activity of LMN-1/lamin, EMR-1/emerin, and LEM-2/MAN1. B0464.8 B0464.8 Protein of unknown function B0464.9 B0464.9 Protein of unknown function B0478.1 jnk-1;B0478.1 Neuronally expressed serine/threonine protein kinase of the MAP kinase subfamily MAP kinase B0478.2 B0478.2 Member of the reverse transcriptase protein family, which are RNA-dependent DNA polymerases, has high similarity to uncharacterized C. elegans H02F09.4 B0478.3 B0478.3 Protein with moderate similarity to C. elegans Y52B11A.8 gene product B0491.1 B0491.1 Protein with moderate similarity to mannosyltransferase I (glycosylphosphatidylinositol mannosyltransferase I, rat Pigm), which transfers the first mannose to glycosylphosphatidylinositol in the endoplasmic reticulum biosynthesis of GPI membrane anchors B0491.2 sqt-1;rol-5;B0491.2 Collagen; member of the Collagen Triple Helix Repeat (20 Copies) protein family cuticle collagen SQT-1 B0491.3 B0491.3 Protein with moderate similarity to C. elegans T05G5.7, which is involved in embryogenesis and morphogenesis B0491.4 B0491.4 Protein containing a neurotransmitter-gated ion-channel ligand binding domain, has low similarity to uncharacterized C. elegans Y74E4A.1 B0491.5 B0491.5 Protein of unknown function B0491.6 B0491.6 Protein of unknown function B0491.7 B0491.7 Protein with high similarity to diphthamide methyltransferase (S. cerevisiae Dph5p), which is required for diphthamide biosynthesis, member of the tetrapyrrole (corrin or porphyrin) methylases family, which use S-AdoMet in substrate methylation diphthine synthase; B0491.7 encodes a putative diphthine synthase orthologous to S. cerevisiae DPH5; DPH5 is an S-adenosylmethionine:EF-2 methyltransferase required for the enzymatic conversion of 3-amino-3-carboxypropyl-histidine to diphthine; DPH5 adds at least the last two of the three methyl groups present in diphthine, and is homologous to bacterial AdoMet:uroporphyrinogen III methyltransferases. B0495.1 sre-1;B0495.1 G protein-coupled receptor, expressed in chemosensory neurons, no homolog found in human or D. melanogaster 7TM chemoreceptor, sre family B0495.10 B0495.10 Protein of unknown function, has a region of low similarity to copine 6 (mouse Cpne6), which is a calcium-dependent phospholipid binding protein that may play roles in Ca2+ sensing and neuronal plasticity B0495.2 B0495.2 Serine/threonine protein kinase of the cyclin-dependent kinase subfamily, has strong similarity to human and D. melanogaster CDC2-like protein kinases (PITSLRE proteins) CDC2 B0495.4 B0495.4 Member of the sodium or hydrogen exchanger family, which control pH in actively metabolizing cells, has moderate similarity to a region of sodium-hydrogen exchanger type 3 (human SLC9A3), which plays roles in sodium absorption and bicarbonate transport NA(+)/H(+) exchanger; nhx-2 encodes a sodium/proton exchanger expressed in the apical membranes of intestinal cells; NHX-2 is required for normally high growth rates, and for propagation or maintenance of the germline, NHX-2 is thought to prevent intracellular acidification by catalysing the electroneutral exchange of extracellular sodium for an intracellular proton. B0495.5 B0495.5 Protein of unknown function B0495.6 B0495.6 Protein of unknown function B0495.7 B0495.7 Protein of unknown function, has low similarity to uncharacterized C. elegans C44B7.11 B0495.8 B0495.8 Member of an uncharacterized protein family B0495.9 B0495.9 Protein of unknown function B0496.1 B0496.1 Protein containing a BTB (BR-C, ttk and babor) or POZ (Pox virus and zinc finger) domain, which are found in some DNA and actin binding proteins and may mediate protein-protein interactions, has high similarity to uncharacterized C. elegans B0496.2 B0496.2 B0496.2 Protein containing a BTB (BR-C, ttk and babor) or POZ (Pox virus and zinc finger) domain, which are found in some DNA and actin binding proteins and may mediate protein-protein interactions, has high similarity to uncharacterized C. elegans R13A1.3 B0496.3 B0496.3 Protein containing two protein kinase domains, has a region of low similarity to rat LOC60328, which is a microtubule/MAP-affinity regulating kinase that participates in microtubule stability and control of cell polarity ser/thr protein kinase B0496.4 B0496.4 Protein of unknown function B0496.5 B0496.5 Protein of unknown function B0496.6 B0496.6 Protein with strong similarity to C. elegans C36H8.1 gene product B0496.7 B0496.7 Protein with high similarity to cysteine-rich intestinal protein (human CRIP1), which binds zinc and may function as a zinc carrier protein, contains LIM domains, which may mediate protein-protein interactions B0496.8 B0496.8 Protein containing three LIM domains, which may mediate protein-protein interactions, has a region of low similarity to a region of four and a half LIM domains 1 (human FHL1) LIM-domain protein B0507.1 B0507.1 Protein with moderate similarity to C. elegans M03F4.6 gene product B0507.10 B0507.10 Protein with strong similarity to C. elegans B0507.7 gene product B0507.2 B0507.2 Protein of unknown function, has weak similarity to S. cerevisiae Yor275p B0507.3 B0507.3 Protein of unknown function B0507.4 B0507.4 Protein with strong similarity to C. elegans ZC196.3 gene product B0507.5 B0507.5 Protein of unknown function B0507.6 B0507.6 Protein of unknown function, has weak similarity to uncharacterized C. elegans F53H2.1 B0507.7 B0507.7 Protein of unknown function, has low similarity to uncharacterized C. elegans B0507.10 B0507.8 B0507.8 Protein of unknown function, has low similarity to uncharacterized C. elegans B0507.9 B0507.9 B0507.9 Protein of unknown function, has low similarity to uncharacterized C. elegans B0507.8 B0511.1 B0511.1 Member of the FKBP-type peptidyl-prolyl cis-trans isomerase family, has weak similarity to a region of FK506 binding protein 10 65 kDa (mouse Fkbp10), which is an immunophilin that interacts with serine/threonine kinase Raf1 and with tropoelastin fkb-7 encodes a peptidylprolyl cis/trans isomerase homologous to mammalian FK506-binding proteins; by homology, FKB-7 could function in a number of different processes including protein folding, signal transduction, and regulation of muscle contraction; however, as loss of fkb-7 function via RNA-mediated interference (RNAi) does not result in any obvious abnormalities, the precise role of FKB-7 in C. elegans development and/or behavior is not yet known. B0511.10 B0511.10 Protein with high similarity to eukaryotic translation initiation factor 3 subunit 6 (human EIF3S6), contains a PCI (proteasome, COP9-complex and eIF3) or PINT (Proteasome, Int-6, Nip-1 and TRIP-15) domain eif-3. B0511.11 B0511.11 Protein of unknown function, has strong similarity to C. elegans K05F6.10 over 61 amino acids of the C-terminus B0511.12 B0511.12 Protein of unknown function, has moderate similarity to uncharacterized mouse Pcnx B0511.13 B0511.13 Protein of unknown function B0511.14 B0511.14 Protein of unknown function B0511.2 B0511.2 Protein with strong similarity to C. elegans Y23H5A.7 gene product B0511.3 B0511.3 Protein containing an F-box domain, which serve as a link between a target protein and a ubiquitin-conjugating enzyme, and a DUF38 domain of unknown function, has low similarity to C. elegans FOG-2, which is required for the sexual identity of germ cells This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins; this gene's encoded protein also contains an FTH/DUF38 motif, which may also mediate protein-protein interaction. B0511.4 B0511.4 Protein containing a protein kinase domain, has low similarity to camKI-like protein kinase (human LOC57118), which is a granulocyte-specific protein kinase that activates ERK/MAP kinase activity protein kinase B0511.5 B0511.5 Protein of unknown function, has low similarity to a region of cuticulin component (C. elegans CUT-1) B0511.6 B0511.6 Member of the DEAD or DEAH box ATP-dependent RNA helicase family, contains a helicase conserved C-terminal domain, has low similarity to S. cerevisiae Rrp3p, which is a helicase required for maturation of pre-rRNA helicase B0511.7 B0511.7 Protein containing a forkhead associated (FHA) domain, which bind phosphopeptides, has moderate similarity to protein phosphatase-1 regulatory 8 (human PPP1R8), which is a site-specific magnesium-dependent endoribonuclease B0511.8 B0511.8 Protein with weak similarity to S. cerevisiae Cdc1p, a protein involved in ion homeostasis, intrachromosomal recombination, and nuclear division B0511.9 B0511.9 Protein of unknown function B0513.1 B0513.1 Protein of unknown function, has low similarity to uncharacterized C. elegans C04B4.4 gei-5 encodes a novel protein that was identified in screens for molecules that interact with GEX-3, a homolog of mammalian protein ligands of the small GTPase Rac1, that is essential for ventral enclosure during embryonic development; as loss of gei-5 function via RNA-mediated interference (RNAi) does not result in any abnormalities, the precise role of GEI-5 in C. elegans development and/or behavior is not yet known; GEI-5 is expressed in body wall and vulval muscles, and is also detected in the intestine, neurons, and probably the hypodermis. B0513.2 B0513.2 Protein of unknown function B0513.3 B0513.3 Protein with high similarity to 60S ribosomal protein L29 (S. pombe Rpl29p), which binds RNA, member of the ribosomal L29e family, which are part of the large ribosomal subunit 60S ribosomal protein L29; rpl-29 encodes a large ribosomal subunit L29 protein; by homology, RPL-29 is predicted to function in protein biosynthesis; in C. elegans, loss of rpl-29 function via RNA-mediated interference (RNAi) does not result in any obvious abnormalities. B0513.4 B0513.4 Protein of unknown function B0513.5 B0513.5 Protein with high similarity to proline oxidase (proline dehydrogenase, human PRODH), which catalyzes conversion of proline to glutamate and is associated with type-I hyperprolinemia and behavioral disorders, member of the proline dehydrogenase family B0513.6 B0513.6 Protein of unknown function, has very strong similarity to uncharacterized C. elegans Y45F10C.1 B0513.7 B0513.7 Member of the transposase family, which are required for excising and inserting mobile genetic elements, has high similarity to uncharacterized C. elegans Y54G11A.8 B0513.9 B0513.9 Member of the synaptobrevin family, which are intrinsic membrane proteins found in small synaptic vesicles B0523.1 Cehd-9;B0523.1 Putative tyrosine protein kinase, has similarity to human and D. melanogaster FER (fps/fes-related) protein kinases Tyrosine kinase; kin-31 encodes a predicted tyrosine protein kinase expressed in the nucleus and cytoplasm of body-wall muscle cells; the expression of kin-31 was experimentally verified by RT-PCR. B0523.3 B0523.3 Putative ortholog of C. elegans B0523.4 gene product B0523.5 Ce-FLI-1;B0523.5 Protein with high similarity to flightless I homolog (human FLII), which is an actin binding protein, contains twelve leucine rich repeats, member of the gelsolin family, which act as actin-modulating proteins that end-block or cap actin filaments fli-1 encodes a homolog of Drosophila flightless-I; can interact with human Ha-Ras and human actin in vitro; mRNA levels are highest in embryos. B0524.2 B0524.E;B0524.2 Protein of unknown function, has moderate similarity to uncharacterized C. elegans D1054.1 B0524.3 B0524.D;B0524.3 Protein with moderate similarity to C. elegans B0524.4 gene product B0524.5 B0524.5 Protein of unknown function, contains similarity to mouse transcription regulator (GB:L35307) B0524.6 B0524.A;B0524.6 Protein of unknown function B0524.B B0524.4;B0524.B Protein containing a WSN domain of unknown function, has low similarity to uncharacterized C. elegans R06B10.2 B0524.F B0524.1;B0524.F Protein of unknown function B0545.1 B0545.1 Putative ortholog of C. elegans tpa-1 gene product protein kinase C B0545.3 B0545.3 Member of the SCP-like extracellular protein family, has moderate similarity to uncharacterized C. elegans F49E11.5 extracellular protein B0545.4 B0545.4 Protein with strong similarity to C. elegans K09A11.1 gene product transposase B0546.1 B0546.1 Protein of unknown function, has weak similarity to C. elegans mai-1 ATPase inhibitor B0546.2 B0546.2 Member of the ovarian tumor (OTU)-like cysteine protease family B0546.3 B0546.3 Protein of unknown function B0546.4 B0546.4 Protein with moderate similarity to C. elegans F37A8.5 gene product B0546.5 B0546.5 Protein of unknown function, has strong similarity to uncharacterized C. elegans F16D3.6 B0547.1 B0547.1 Protein with high similarity to constitutive photomorphogenic subunit 5 (human COPS5), which is a subunit of the signalosome complex that phosphorylates regulators involved in signal transduction, member of the Mov34, MPN or PAD-1 family csn-5 encodes an ortholog of subunit 5 of the COP9 signalosome complex (CSN5), which in turn is a pan-eukaryotic multiprotein complex that positively regulates E3 ubiquitin ligases, physically interacts with SCF-type E3 ubiquitin ligases, and probably regulates protein degradation; CSN-5 (along with KGB-1 and ZYX-1) physically binds germline RNA helicases (GLH proteins), and csn-5(RNAi) results in sterile worms with small gonads and no oocytes, causing oogenesis to cease, but not affecting the initial assembly of P granules -- a defect essentially identical to that produced by RNAi with a combination of glh-1 and glh-4. B0547.2 B0547.2 Protein of unknown function B0547.4 B0547.4 Protein of unknown function, has high similarity to uncharacterized C. elegans C06G8.4 7TM chemoreceptor, srd family B0554.1 B0554.1 Protein of unknown function B0554.2 B0554.2 Protein containing five DUF225 domains of unknown function, has high similarity to uncharacterized C. elegans B0554.4 B0554.3 B0554.3 Protein of unknown function B0554.4 B0554.4 Protein containing one DUF225 domain of unknown function, has high similarity to uncharacterized C. elegans B0554.2 B0554.5 B0554.5 Protein of unknown function, has strong similarity to uncharacterized C. elegans Y39D8A.1 B0554.6 B0554.6 Protein of unknown function, has high similarity to uncharacterized C. elegans ZK6.11 B0554.7 B0554.7 Protein of unknown function, has high similarity to uncharacterized C. elegans Y39D8A.1 B0563.1 B0563.1 Protein of unknown function B0563.2 B0563.2 Member of the tetraspanin family, which contain an N-terminal transmembrane domain that is a signal sequence and membrane anchor, has low similarity to CD53 antigen (human CD53), which is a pan-leukocyte cell surface antigen transpanin B0563.3 B0563.3 Protein containing one uncharacterized domain UPF0005 B0563.4 B0563.4 Protein of unknown function B0563.5 B0563.5 Protein of unknown function B0563.6 B0563.6 Member of the rhodopsin family of G protein-coupled receptors (GPCR), has weak similarity to somatostatin receptor 5 (rat Sstr5), which inhibits adenylyl cyclase activity and mediates inhibitory effects of somatostatin on cell proliferation and secretion B0563.7 B0563.7 Protein containing four EF hand domains, which are found in signaling, buffering or transport proteins, has weak similarity to myosin regulatory light chain (human MLCB), which is involved in RHO protein and G protein-coupled receptor signal transduction Calmodulin B0563.8 B0563.8 Protein of unknown function B0564.1 B0564.1 Member of the RNase PH family of 3' exoribonucleases, which are involved in RNA processing, has low similarity to S. cerevisiae Ski6p, which is a component of the exosome 3'-5' exoribonuclease complex involved in 3' processing and degradation of RNA B0564.10 unc-30;B0564.10 Homeodomain transcription factor specifically expressed in GABAergic neurons, is required for axonal pathfinding; has similarity over 293 amino acids to human PITX2 paired-like homeodomain transcription factor homeobox protein (otd subfamily); unc-30 encodes a paired-like homeodomain transcription factor orthologous to vertebrate Pitx homeodomain proteins, such as mouse Pitx2; UNC-30 controls the terminal differentiation of all 19 type D GABA-ergic motor neurons by directly regulating the expression of UNC-25/GAD and UNC-47/VGAT, which are responsible for GABA formation and secretion, respectively; UNC-30 is expressed most strongly in type D motor neurons during early L1 and L2 larval stages. B0564.2 B0564.2 Protein of unknown function B0564.3 B0564.3 Member of the C. elegans putative membrane protein family 8, has low similarity to a region of bestrophin (human VMD2), which plays a role in vision and is associated with Bests disease, adult vitelliform macular dystrophy, and bull's eye maculopathy Putative membrane protein B0564.4 B0564.4 Member of the C. elegans putative membrane protein family 8, has moderate similarity to a region of bestrophin (human VMD2), which plays a role in vision and is associated with Bests disease, adult vitelliform macular dystrophy, and bull's eye maculopathy Putative membrane protein B0564.5 B0564.5 Member of the transposase family, which are required for excising and inserting mobile genetic elements, has very strong similarity to uncharacterized C. elegans F44F4.8 transposase B0564.6 B0564.6 Protein containing leucine rich repeats, which mediate protein-protein interactions, has very strong similarity to uncharacterized C. elegans B0564.9 Leucine Rich Repeat (2 copies) (2 domains) B0564.7 B0564.7 Protein containing a C3HC4 type RING zinc finger, which may mediate protein-protein interactions Zinc finger, C3HC4 type (RING finger) B0564.9 B0564.9 Protein containing leucine rich repeats, which mediate protein-protein interactions, has very strong similarity to uncharacterized C. elegans B0564.6 Leucine Rich Repeat (2 copies) (2 domains) BC1 bc1 Putative ortholog of C. elegans Y73E7A.6 gene product BE0003N10.1 BE0003N10.1 Protein with weak similarity to C. elegans B0564.1 gene product BE0003N10.2 BE0003N10.2 Protein of unknown function BE0003N10.3 BE0003N10.3 Putative ortholog of C. elegans F46E10.A gene product BE10.1 BE10.1 Protein of unknown function, has low similarity to uncharacterized C. elegans T28C6.5 BE10.2 BE10.2 Protein of unknown function BE10.3 BE10.3 Protein of unknown function, has a region of low similarity to C. elegans PHA-1, which is involved in pharyngeal development BE10.4 BE10.4 Protein of unknown function BRE-5 bre-5 Putative beta-1,3-galactosyltransferase, mutations in which lead to resistance to several B. thuringiensis toxins C01A2.1 C01A2.1 Protein with moderate similarity to C. elegans ZK402.1 gene product C01A2.2 C01A2.2 Protein of unknown function C01A2.3 C01A2.3 Member of the 60Kd inner membrane protein family, has low similarity to S. cerevisiae Oxa1p, which is required for assembly of F1F0-ATP synthase and cytochrome oxidase and for export of Cox2p termini through the inner mitochondrial membrane cytochrome oxidase biogenesis protein like C01A2.4 C01A2.4 Protein of unknown function, has low similarity to uncharacterized human BC-2 C01A2.5 C01A2.5 Protein of unknown function, has moderate similarity to uncharacterized human C20orf43 S.pombe hypothetical protein C1D4.09C like C01A2.6 C01A2.6 Protein of unknown function C01A2.7 C01A2.7 Protein of unknown function C01B10.1 C01B10.1 Member of the DEAD or DEAH box ATP-dependent RNA helicase family and contains a helicase conserved C-terminal domain, has high similarity to uncharacterized C. elegans F15B10.2 C01B10.10 C01B10.10 Member of the carboxylesterase type B family, has low similarity to esterase 2 (rat Es2), which catalyzes hydrolysis of a variety of carboxylic esters including the anti-cholesteraemic agent clofibrate and may have a role in lipid metabolism C01B10.3 C01B10.3 Protein of unknown function, has a region of weak similarity to inositol polyphosphate-5-phosphatase II (5 phosphatase II, human INPP5A), which hydrolyzes various signaling molecules including inositol 1,4,5 trisphosphate C01B10.4 C01B10.4 Member of the carboxylesterase type B family, has low similarity to C. elegans GES-1, which is a carboxylesterase expressed in gut cells C01B10.5 H1.Q;C01B10.5 Histone H1 hil-7 encodes a histone H1.1 isoform that is required in the germline for chromatin silencing (assayed by silencing of transgenic DNA), for proliferation and differentiation, and for fertility; hil-7(RNAi) phenotypes resemble the Mes phenotype resulting from the desilencing of genes required for somatic differentiation in the germline; HIL-7 is required in both the hermaphrodite and the male germlines, and is ubiquitously expressed in all nuclei (somatic and germline). C01B10.6 C01B10.6 Protein of unknown function C01B10.7 C01B10.7 Protein with moderate similarity to C. elegans K02E11.6 gene product C01B10.8 C01B10.8 Member of the spermine and spermidine synthesis family, which are involved in spermidine biosynthesis, has low similarity to uncharacterized human CGI-01 C01B10.9 C01B10.9 Protein containing a type I phosphodiesterase or nucleotide pyrophosphatase domain, has weak similarity to a region of ectonucleotide phosphodiesterase 3 (rat LOC54410), which releases nucleoside 5' monophosphates C01B12.1 C01B12.1 Protein with high similarity to C. elegans ROL-8, which is structurally similar to vertebrate type IX collagens, contains two collagen triple helix repeats, which are found in some extracellular proteins, and a nematode cuticle collagen N-terminal domain cuticular collagen; Uncloned locus that affects alae formation and body morphology such that mutants exhibit a slightly dumpy phenotype and the bodies of mutants are helically twisted. C01B12.2 C01B12.2 Protein containing a SAND (Sp100,AIRE-1, NucP41/75 and DEAF-1/suppressin) domain, which may bind DNA, has a region of low similarity to a region of glucocorticoid modulatory element binding protein 1 (human GMEB1) C01B12.3 C01B12.3 Member of the C. elegans putative membrane protein family 8, has a region of moderate similarity to a region of bestrophin (human VMD2), which plays a role in vision and causes Bests disease, adult vitelliform macular dystrophy, and bull's eye maculopathy C01B12.3 is orthologous to the human gene VITELLIFORM MACULAR DYSTROPHY PROTEIN (VMD2; OMIM:153700), which when mutated leads to disease. C01B12.4 C01B12.4 Protein of unknown function, has low similarity to uncharacterized C. elegans W01D2.5 C01B12.5 C01B12.5 Member of the C. elegans putative membrane protein family 8, has a region of moderate similarity to a region of bestrophin (human VMD2), which plays a role in vision and causes Bests disease, adult vitelliform macular dystrophy, and bull's eye maculopathy C01B12.6 C01B12.6 Member of the Tc3 Transposase protein family transposase C01B12.7 C01B12.7 Protein of unknown function C01B12.8 C01B12.8 Protein of unknown function C01B4.2 C01B4.2 Protein with strong similarity to C. elegans Y19D10A.3 gene product C01B4.3 C01B4.3 Protein of unknown function, has similarity to C. elegans olfactory receptor ODR-10 7TM chemoreceptor, str family C01B4.5 C01B4.5 Protein of unknown function, has similarity to C. elegans SRD-1 7TM chemoreceptor, srd family C01B4.7 C01B4.7 Protein with similarity to human and D. melanogaster sodium-dependent inorganic phosphate cotransporters C01B4.B C01B4.10;C01B4.B Member of the 7-transmembrane chemoreceptor family of G protein-coupled receptors (GPCR), has weak similarity to C. elegans ODR-10, which is a G protein-coupled receptor involved in odorant response C01B4.E C01B4.9;C01B4.E Protein with weak similarity to solute carrier family 16 member 7 (monocarboxylate cotransporter 2, rat Slc16a7), which mediates the transport of lactate and pyruvate across plasma membranes C01B4.G C01B4.8;C01B4.G Member of the sugar (and other) transporter family, has low similarity to solute carrier family 17 member 1 (mouse Slc17a1), which is involved in sodium-dependent phosphate transport and hepatic and renal anion drug transport C01B4.H C01B4.6;C01B4.H Member of the aldose 1-epimerase family, which interconvert aldoses between their alpha- and beta-forms, has low similarity to a region of S. cerevisiae Gal10p, which an UDP-glucose 4-epimerase that catalyzes a step in galactose metabolism C01B4.J C01B4.1;C01B4.J Member of the 7-transmembrane chemoreceptor family of G-protein coupled receptors (GPCR), has low similarity to C. elegans ODR-10, which is a G protein-coupled receptor involved in odorant response C01B7.1 C01B7.1 Protein containing four C2H2 type zinc finger domains, which bind nucleic acids zinc finger protein C01B7.3 C01B7.3 Protein of unknown function C01B7.4 C01B7.4 Protein containing a Src homology 3 (SH3) domain, guanylate kinase domain, and a PDZ, DHR or GLGF domain, has weak similarity to postsynaptic density-95 (mouse Dlgh4), which is a scaffolding protein that recruits neurotransmitter receptors and channels guanylate kinase; This gene encodes a protein predicted by Eisenberg and coworkers, with 68% accuracy, to be mitochondrial. C01B7.5 C01B7.5 Protein containing a PDZ, DHR, or GLGF domain, which are found in signaling proteins C01B7.6 rpm-1;sad-3;syd-3;C01B7.6 Protein involved in pre- and post-synaptic terminal development in motor neurons C01B7.7 C01B7.7 Protein containing a DUF19 domain of unknown function, which contain twelve conserved cysteines, has very strong similarity to uncharacterized C. elegans F07B7.13 C01B9.1 C01B9.1 Protein containing an F-box domain, which serve as a link between a target protein and a ubiquitin-conjugating enzyme, and three DUF38 domains of unknown function, has high similarity to uncharacteriized C. elegans R10E8.6 C01B9.2 C01B9.2 Protein of unknown function that may be anchored to the membrane of a secretory vesicle or the Golgi apparatus C01C10.1 C01C10.1 Putative tetraspan transmembrane protein in an operon with C01C10.1a; similar to human Gas3/PMP22, a member of the growth arrest specific, peripheral myelinating protein family clc-2 encodes a claudin homolog, closely similar to CLC-1, that is required for normal cohesion of apical junctions in epithelia; claudins are integral membrane proteins with four transmembrane sequences that are found in mammalian tight junctions (TJs), induce TJs when transgenically expressed in cells normally lacking them, and can mediate the specific conductance of of specific ions (e.g., magnesium or calcium) through TJs while blocking the flow of water; CLC-2 maintains the impermeability ('barrier function') of epithelia, since clc-1(RNAi) animals have abnormal permeability of the hypodermis to dyes; clc-2 is expressed in hypodermal seam cells, with two diffuse lines of CLC-2 protein. C01C10.2 C01C10.2 Protein of unknown function C01C10.3 C01C10.3 Protein of unknown function, has moderate similarity to uncharacterized C. elegans F08G5.2 C01C10.4 C01C10.4 Putative ortholog of C. elegans C01C10.1b gene product clc-5 encodes a claudin homolog that may be required for normal cohesion of apical junctions in epithelia; CLC-5 is worm-specific, with obvious homologs only in C. elegans; CLC-5 has no obvious function in mass RNAi assays; claudins are integral membrane proteins with four transmembrane sequences that are found in mammalian tight junctions (TJs), induce TJs when transgenically expressed in cells normally lacking them, and can mediate the specific conductance of of specific ions (e.g., magnesium or calcium) through TJs while blocking the flow of water. C01C4.1 C01C4.1 MSFamide neurotransmitter A. californica buccalin precursor (weak); nlp-1 encodes a predicted neuropeptide-like protein of the MSFamide family with similarity to Aplysia californica (sea hare) buccalin, a neuropeptide that regulates acetylcholine-induced muscle contraction; NLP-1 is expressed in the phasmid PHB tail sensory neuron, lateral neurons, head neurons, and the intestine; the precise role of NLP-1 in nervous system function and development is not yet known. C01C4.2 C01C4.2 Protein of unknown function C01C4.3 C01C4.3 Protein containing a protein kinase domain, has low similarity to a region of checkpoint kinase 2 (mouse Rad53), which is a protein kinase that may transmit signals from ataxia telangiectasia mutated kinase (Atm) that are generated after DNA damage serine/threonine protein kinase C01C7.1 ark-1;C01C7.1 Putative tyrosine protein kinase, has similarity to H. sapiens p21cdc42 protein kinase that inhibits p21cdc42, has similarity to D. melanogaster PR2 protein Src homology domain 3, tyrosine-protein kinase (ACK subfamily); ark-1 encodes a homolog of the nonreceptor tyrosine kinase ACK which inhibits signalling through the EGF receptor homolog LET-23, both in (RAS-dependent) vulval development and in (RAS-independent) ovulation. C01F1.1 C01F1.1 Protein with low similarity to general transcription factor IIF polypeptide 1 (human GTF2F1), which is required for transcriptional initiation by RNA polymerase II and stimulates mRNA transcription elongation dna binding protein C01F1.2 C01F1.2 Member of the SCO1-SenC family, which are involved in biogenesis of respiratory and photosynthetic systems, has a region of high similarity to a region of cytochrome oxidase deficient 1 (human SCO1) C01F1.2 is orthologous to the human gene SCO (CYTOCHROME OXIDASE DEFICIENT, YEAST) HOMOLOG 1 (SCO1; OMIM:603644), which when mutated leads to early-onset hepatic failure; the C01F1.2 protein is predicted to be mitochondrial with 68% accuracy. C01F1.3 C01F1.3 Member of the NAD-dependent epimerase or dehydratase family, which catalyze reactions involving nucleotide sugar substrates, has a region of weak similarity to UDP-glucuronate decarboxylase (C. neoformans Uxs1_D) C01F1.4 C01F1.4 Protein of unknown function, has low similarity to uncharacterized C. elegans H02I12.3 C01F1.5 C01F1.5 Protein of unknown function C01F1.6 C01F1.6 Protein containing three ankyrin (Ank) repeats, which may mediate protein-protein interactions, has moderate similarity to uncharacterized human DKFZP566D1346 C01F4.1 C01F4.1 Protein of unknown function C01F4.2 C01F4.2 Protein containing a RhoGAP (GTPase activator protein) domain, has a region of low similarity to a region of rho GTPase activating protein 6 (mouse Arhgap6), which is a multiple splice form GTPase activating protein (GAP) for mouse Arha2 C01F4.3 C01F4.3 Protein of unknown function C01F6.1 C01F6.1 Protein with low similarity to copine 6 (mouse Cpne6), which is a calcium-dependent phospholipid binding protein and may play roles in Ca2+ sensing and neuronal plasticity C01F6.2 C01F6.2 Protein of unknown function C01F6.3 C01F6.3 Member of the cytochrome P450 family, has low similarity to cytochrome P450 4B1 (mouse Cyp4b1), which converts several compounds to active carcinogens and may function in chemical carcinogenesis in extrahepatic tissues C01F6.4 fem-3;isx-3;C01F6.4 Protein involved in somatic sex determination and in spermatogenesis sex-determining protein (FEM-3); fem-3 encodes a novel protein that promotes male development in all tissues. C01F6.5 C01F6.5 Protein with low similarity to S. cerevisiae Yra1p, which has RNA:RNA annealing activity and is involved in mRNA packaging for export from the nucleus RNA recognition motif. (aka RRM, RBD, or RNP domain) C01F6.6 C01F6.6 Protein containing two PDZ, DHR, or GLGF domains, has weak similarity to solute carrier family 9 isoform 3 regulatory factor 1 (sodium-hydrogen exchanger-regulatory factor, human LOC59114), which is a cytoskeleton-linking protein PDZ domain (Also known as DHR or GLGF). C01F6.8 ICln;C01F6.8 Protein with low similarity to swelling-induced chloride conductance regulatory protein (rat Clns1a), which may be a chloride channel regulator that may participate in regulation of chloride transport and cell volume nucleotide-sensitive chloride ion channel; The icl-1 gene encodes, through alternative splicing, two alternative forms (ICL-1A, or 'IClnN1', and ICL-1B, or 'IClnN2'), with distinct electrophysiological properties, of an anion channel homolog. C01F6.9 Nx;C01F6.9 Protein of unknown function, has weak similarity to C. elegans K10B3.1 The C01F6.9 gene resides in an operon that also contains the genes icl-1 and lpl-1. C01G10.1 C01G10.1 Protein containing an ankyrin (Ank) repeat, which may mediate protein-protein interactions, a BRCA1 (breast cancer type 1) C terminus (BRCT) domain, and a WSN domain, has high similarity to uncharacterized C. elegans F26D2.10 ankyrin repeat C01G10.10 C01G10.10 Member of the M22 glycoprotease family, has low similarity to uncharacterized human LOC64172 O-sialoglycoprotein endopeptidase C01G10.11 unc-76;C01G10.11 Protein of the FEZ (Fasciculation and Elongations proteins; Zygin/Zeta-1) family, involved in controlling axon-axon interactions within a fascicle UNC-76 protein C01G10.12 C01G10.12 Protein containing one DnaJ domain, which are part of chaperone (protein folding) system that mediates interaction with heat shock proteins, has a region of moderate similarity to a region of S. cerevisiae Jem1p, which is required for nuclear fusion DNAJ protein; This gene encodes a protein containing a DnaJ ('J') domain. C01G10.13 C01G10.13 Protein with strong similarity to C. elegans T05H4.8 gene product C01G10.14 C01G10.14 Protein containing a major sperm protein (MSP) domain, which are involved in sperm motility C01G10.2 C01G10.2 Protein of unknown function, has high similarity to uncharacterized C. elegans C01G10.3 C01G10.3 C01G10.3 Protein of unknown function, has high similarity to uncharacterized C. elegans C01G10.2 7TM receptor, srx family C01G10.4 C01G10.4 Protein of unknown function C01G10.5 C01G10.5 Protein of unknown function C01G10.6 C01G10.6 Protein of unknown function C01G10.7 C01G10.7 Protein of unknown function citrate lyase beta chain C01G10.8 C01G10.8 Protein of unknown function, has moderate similarity to uncharacterized human C14ORF3 C01G10.9 C01G10.9 Putative ortholog of S. cerevisiae Ypr118p, a protein of unknown function Initiation factor 2 subunit C01G12.1 C01G12.1 Protein of unknown function, has similarity over N-terminal 100 amino acids to D. melanogaster ADF1 (Adh transcription factor 1) C01G12.2 C01G12.2 Protein with moderate similarity to C. elegans C01G12.6 gene product C01G12.3 C01G12.3 Protein of unknown function, has high similarity to uncharacterized C. elegans F44G4.5 C01G12.5 C01G12.5 Member of the short-chain dehydrogenase-reductase family, which are NAD- or NADP-dependent oxidoreductases, has low similarity to hydroxyprostaglandin dehydrogenase 15-NAD (human HPGD), which inactivates prostaglandins by oxidation Alcohol/other dehydrogenases, short chain type; This gene encodes a protein predicted by Eisenberg and coworkers, with 68% accuracy, to be mitochondrial. C01G12.6 C01G12.6 Protein of unknown function, has high similarity to uncharacterized C. elegans F35C5.10 C01G12.7 C01G12.7 Protein of unknown function C01G12.8 C01G12.8 Protein with high similarity to sodium-potassium ATPase alpha subunit (C. elegans EAT-6), member of the haloacid dehalogenase or epoxide hydrolase and the E1-E2 ATPase families, contains cation transporting ATPase N-terminal and C-terminal domains sodium/potasssium transporting ATPase C01G5.2 prg-2;C01G5.2 Protein containing a piwi domain and a PAZ (Piwi, Argonaut and Zwille) domain, which may mediate protein-protein interactions, has low similarity to piwi (Drosophila)-like 1 (human PIWIL1), which functions in control of cell proliferation and apoptosis C01G5.3 C01G5.3 Putative ortholog of C. elegans Y75B7B.1 gene product C01G5.4 C01G5.4 Protein containing a WSN domain of unknown function, has moderate similarity to uncharacterized C. elegans C09B9.7 C01G5.5 C01G5.5 Member of the aldo-keto reductase family, which include some related monomeric NADPH-dependent oxidoreductases, has low similarity to aldose reductase (rat Akr1b1), which reduces glucose and other carbonyl-containing substrates aldehyde reductase C01G5.6 C01G5.6 Member of the retroviral aspartyl protease family, has a region of moderate similarity to a region of S. cerevisiae Ddi1p, which binds to t- and v-SNARE complexes and also interacts with S. cerevisiae Rad23p C01G5.7 C01G5.7 Protein of unknown function C01G5.8 C01G5.8 Protein of unknown function, has low similarity to uncharacterized human KIAA1018 C01G5.9 C01G5.9 Protein with strong similarity to C. elegans C08B6.3 gene product C01G6.1 AQP;C01G6.1;aqp-ce1 Protein with strong similarity to H. sapiens AQP3 (aquaporin 3) glycerol uptake facilitator protein C01G6.2 C01G6.2 Protein with strong similarity to C. elegans Y11D7A.15 gene product C01G6.3 C01G6.3 Protein of unknown function C01G6.4 C01G6.4 Protein containing a C3HC4 type RING zinc finger, which may mediate protein-protein interactions, has moderate similarity to uncharacterized human RNF11 Zinc finger, C3HC4 type (RING finger) C01G6.5 C01G6.5 Protein containing a forkhead associated (FHA) domain, which bind phosphopeptides Forkhead-associated (FHA) domain C01G6.6 C01G6.6 Member of the NADP-cytochrome P450 reductase (tentative) protein family NADPH-ferrihemoprotein reductase C01G6.7 C01G6.7 Member of the AMP-binding enzyme family, has low similarity to S. cerevisiae Fat2p, which is a peroxisomal AMP-binding protein 4-coumarate-coA ligase C01G6.9 C01G6.9 Protein of unknown function C01G8.1 C01G8.1 Protein of unknown function C01G8.2 cln-3.2;C01G8.2 Member of the CLN3 protein family, which are involved in Batten disease, has moderate similarity to ceroid-lipofuscinosis neuronal 3 (human CLN3), which plays a role in lysosomal pH homeostasis cln-3.2 encodes a predicted transmembrane protein that comprises one of three C. elegans homologs of human CLN3 (OMIM:607042, mutations are associated with Batten disease (also known as juvenile neuronal ceroid lipofuscinosis), a recessively inherited childhood neurodegenerative disorder characterized by progressive loss of vision, seizures, and psychomotor abnormalities); by homology, CLN-3.2 is predicted to localize to Golgi and lysosomal membranes, where its proposed functions include that of a chaperone and/or a regulator of intracellular trafficking; in C. elegans, loss of cln-3.2 activity via mutation or RNA-mediated interference (RNAi) does not result in any obvious abnormalities (nor does loss of all three CLN3 homologs, cln-3.1, cln-3.2, and cln-3.3), suggesting that these genes do not play an essential role in development and/or behavior. C01G8.3 C01G8.3 Member of the short-chain dehydrogenase-reductase family, which are NAD- or NADP-dependent oxidoreductases, has low similarity to a region of WW domain-containing oxidoreductase (mouse Wwox), which is an apoptosis activator induced by hyaluronidase oxidoreductase C01G8.4 C01G8.4 Protein containing a DnaJ domain, which are part of the chaperone (protein folding) system that mediates interaction with heat shock proteins This gene encodes a protein containing a DnaJ ('J') domain. C01G8.5 C01G8.5 Protein with high similarity to moesin (human MSN), which is a putative receptor that may link the cytoskeleton and plasma membrane, member of the ezrin, radixin or moesin family, which link actin filaments to the plasma membrane, contains FERM domains membrane protein; The erm-1 gene encodes an ortholog of the ERM family of cytoskeletal linkers with approximately equal similarity to ezrin, radixin and moesin. C01G8.6 C01G8.6 Protein of unknown function, has weak similarity to human dentin phosphoryn and S. cerevisiae Aga1p (a-Agglutinin anchor subunit) C01G8.9 C01G8.9 Putative ortholog of C. elegans C01G8.7 gene product C01H6.1 C01H6.1 Protein containing two collagen triple helix repeats, which are found in some extracellular proteins, and a nematode cuticle collagen N-terminal domain, has a region of high similarity to a region of C. elegans BLI-1 collagen C01H6.2 C01H6.2 Protein containing seven ankyrin (Ank) repeats, which may mediate protein-protein interactions, has a region of low similarity to a region of ankyrin (rat Ank3), which is an anchoring protein that links integral membrane proteins to the cytoskeleton Ank repeat (2 domains); This gene encodes a protein predicted by Eisenberg and coworkers, with 52% accuracy, to be mitochondrial. C01H6.3 C01H6.3 Protein of unknown function C01H6.4 C01H6.4 Member of the flavin-binding monooxygenase family, which are xenobiotic-metabolising enzymes, has low similarity to flavin containing monooxygenase 5 (human FMO5) Flavin-binding monooxygenase-like C01H6.5 nhr-23;NR1F4;chr3;C01H6.5 Member of the retinoic acid receptor (RAR) subfamily of thyroid hormone receptors; involved in cuticle development and molting nuclear hormone receptor; The nhr-23 gene encodes a nuclear hormone receptor homolog that is required in all larval molts; NHR-23 is highly similar to Drosophila DHR3, an ecdysone-inducible gene product involved in metamorphosis; NHR-23 is required for hypodermal expression of acn-1 and, probably, of dpy-7. C01H6.6 C01H6.6 Protein containing a DUF21 domain of unknown function, has weak similarity to a region of S. cerevisiae AMI3, which is required for normal mitochondrial structure C01H6.6 encodes a homolog of human ACDP1-ACDP4 and a paralog of C33D12.2, C52D10.12, M02F4.3, R04E5.2, and R13G10.4; both C01H6.6 and ACDP1-ACDP4 belong to a family of proteins (defined by NCBI as KOG2118) that are predicted to be membrane-spanning and that share a motif (the 'ACD domain') with proteins from bacteria, yeast, plants, and metazoa; murine Acdp1 is a plasma membrane protein bacterial proteins containing the ACD domain include CorC from Salmonella typhimurium, which is involved in magnesium and cobalt efflux; C01H6.6 has no obvious function in RNAi assays. C01H6.7 C01H6.7 Protein containing a bromodomain, which interact specifically with acetylated lysine, has a region of low similarity to a region of C. elegans CBP-1, which is a transcriptional activator,involved in histogenesis and organogenesis Bromodomain C01H6.8 C01H6.8 Protein of unknown function C01H6.9 C01H6.9 Protein containing two protein kinase domains, has a region of low similarity to germ cell-specific gene 2 (haspin) (mouse Gsg2), which is a serine-threonine kinase that binds DNA and may be involved in cell cycle cessation Eukaryotic protein kinase domain; C01H6.9 encodes a homolog of haploid germ cell-specific nuclear protein kinase (haspin) that specifically binds GOA-1 in yeast two-hybrid assays; C01H6.9 is expressed in PHB sensory neurons and PVT interneurons in the tail, several unidentified neurons in the head (with projections to the nose and nerve ring), and intestinal cells, with mainly nuclear localization; C01H6.9 has no obvious function or phenotype in RNAi assays, either alone or with inactivation of a close paralog (F22H10.5). C02A12.1 C02A12.1 Protein containing a glutathione S-transferase N-terminal and C-terminal domains, has low similarity to prostaglandin D2 synthase 2 (rat Ptgds2), which acts as a glutathione S-transferase and a prostaglandin D synthase in prostaglandin D2 biosynthesis glutathione S-transferase C02A12.2 C02A12.2 Protein containing a DUF40 domain of unknown function, which contain four conserved cysteines, and a DUF33 domain of unknown function, has high similarity to uncharacterized C. elegans R03H4.1 C02A12.3 C02A12.3 Protein containing two DUF40 domains of unknown function, which contain four conserved cysteines, has moderate similarity to uncharacterized C. elegans C02A12.5 C02A12.4 C02A12.4 Member of an uncharacterized protein family with weak similarity to Entemeba histolytica N-acetylmuraminidase lys-7 encodes an enzyme homologous to an antimicrobial lysozyme encoded by the LYS4 gene of the protozoan parasite Entamoeba histolytica; by homology, LYS-7 is predicted to function as an antimicrobial enzyme that hydrolyzes the 1,4-beta-linkages between N-acetyl-D-glucosamine and N-acetylmuramic acid in peptidoglycan heteropolymers of prokaryotic cell walls; in C. elegans, lys-7 expression is significantly upregulated in response to infection with the Gram-negative bacterium Serratia marcescens, indicating that LYS-7 likely plays a role in the innate immune response; constitutive expression of lys-7 mRNA is detected in the intestine and the intestinal valve cells. C02A12.5 C02A12.5 Protein containing two DUF40 domains of unknown function, which contain four conserved cysteines, has moderate similarity to uncharacterized C. elegans C02A12.3 C02A12.6 C02A12.6 Protein containing a DUF40 domain of unknown function, which contain four conserved cysteines, has high similarity to uncharacterized C. elegans C07G3.7 C02A12.7 C02A12.7 Protein with strong similarity to C. elegans K07E8.10 gene product C02B10.1 IVD;C02B10.1 Mitochondrial isovaleryl-CoA reductase; functions in leucine metabolism acyl-CoA dehydrogenase; The C02B10.1 gene encodes an isovaleryl-CoA dehydrogenase; this function has been verified by both sequence homology and direct biochemical assay. C02B10.2 C02B10.2 Protein of unknown function C02B10.3 C02B10.3 Protein containing an epidermal growth factor (EGF)-like domain, has a region of low similarity to a region of jagged 1 (rat Jag1), which is a ligand for the Notch receptor that may control cell fate determination, proliferation, and differentiation C02B10.4 C02B10.4 Protein containing an RNA recognition motif (RRM, RBD, or RNP) C02B10.5 C02B10.5 Protein of unknown function, contains proline-rich domains, has weak similarity in the C-terminal portion to the human glutamine rich protein KIAA0181 (Hs.159613) C02B10.6 C02B10.6 Member of the protein-tyrosine phosphatase family, which are involved in cell growth control, proliferation, differentiation and transformation, has moderate similarity to C. elegans F10G8.1, which is involved in embryogenesis or morphogenesis C02B4.1 adt-1;C02B4.1 Member of the reprolysin (M12B) zinc metalloprotease family, contains twelve thrombospondin type 1 domains, involved in male tail morphogenesis TSP type-1 repeats (13); The adt-1 gene encodes a metalloproteinase with disintegrin-like and metalloproteinase with thrombospondin type I motifs (ADAMTS) that is required for male tail morphogenesis. C02B4.2 nhr-17;C02B4.2 Member of the nuclear hormone receptor/Zinc finger protein family nuclear hormone receptor C02B4.3 C02B4.3 Protein of unknown function C02B8.1 C02B8.1 Protein with strong similarity to C. elegans ZK507.6 gene product C02B8.2 C02B8.2 Putative ortholog of C. elegans F31A9.4 gene product C02B8.3 C02B8.3 Protein of unknown function, has high similarity to uncharacterized C. elegans F58E10.7 C02B8.4 hlh-8;bHLH-8;CeTwist;C02B8.4 Helix-loop-helix DNA-binding domain family member; involved in the development and differentiation of several different mesoderm-derived cells MYC family of helix-loop-helix transcription factors; The hlh-8 gene encodes a helix-loop-helix protein required for normal muscle development, and hence for normal defecation and egg-laying. C02B8.5 C02B8.5 Protein with strong similarity to C. elegans K07E8.5 gene product C02B8.5 encodes a homolog of the functionally active Fmrf Receptor (FR; CG2114) of D. melanogaster; it is thus possible that C02B8.5 is a receptor for one of the FMRF-like neurotransmitters in C. elegans (e.g., FLP-1 through FLP-12). C02B8.6 C02B8.6 Protein containing two C3HC4 type RING zinc fingers, which may mediate protein-protein interactions, and two WWE domains, which may mediate protein interactions in ubiquitin and ADP ribose conjugation systems DNA repair protein RAD16 (yeast, weak) C02B8.7 C02B8.7 Protein with moderate similarity to C. elegans C02B8.3 gene product C02C2.2 C02C2.1;C02C2.2 Protein containing a tyrosinase central domain, which are copper-binding domains, has high similarity to uncharacterized C. elegans K08E3.1 C02C2.3 C02C2.3 Protein containing a neurotransmitter-gated ion-channel ligand binding domain, has weak similarity to muscle cholinergic receptor nicotinic alpha subunit 1 (mouse Chrna1), which contains major binding sites for acetylcholine Acetylcholine receptor; The primary phenotype of cup-4 animals is an accumulation of secreted GFP in the pseudocoelom, suggesting a decrease in, or the absence of, endocytosis in coelomocytes. C02C2.4 C02C2.4 Protein with similarity to human and D. melanogaster sodium-dependent inorganic phosphate cotransporters, member of the major facilitator superfamily C02C2.5 C02C2.5 Member of the nitroreductase family, which utilize FMN as a cofactor C02C6.1 dyn-1;C02C6.1 Dynamin dynamin C02C6.2 C02C6.2 Protein of unknown function C02C6.3 C02C6.3 Protein containing four leucine rich repeats, which mediate protein-protein interactions, and a leucine rich repeat C-terminal cysteine rich domain, has weak similarity to trophoblast glycoprotein (human TPBG), which is a cells surface antigen Leucine Rich Repeat (2 copies) C02D4.1 C02D4.1 Protein of unknown function C02D4.2 C02D4.2 Member of the rhodopsin family of G protein-coupled receptors (GPCR), has low similarity to 5-hydroxytryptamine (serotonin) 1A receptor (rat Htr1a), which inhibits adenylyl cyclase and plays a role in anxiety, nociception, sleep and feeding behavior octopamine receptor; ser-2 encodes at least four tyramine 7-transmembrane domain receptors (GPCRs), by alternative splicing from three different promoters, that have distinct but partially overlapping expression patterns; ser-2 has at least three alternative promoters that drive SER-2 expression in a set of sensory, inter- and motor neurons (e.g., AIY, AIZ, and RIA) adding up to ~10% of all neurons in the nervous system, as well as pharyngeal cells and head muscles; the deletion ser-2(pk1397) has no obvious mutant phenotype; LIM-4 is required for SER-2 expression, and MAB-23 is required for SER-2 expression at normally high levels. C02D5.1 C02D5.1 Protein containing an acyl-CoA dehydrogenase N-terminal, middle, and C-terminal domains, has low similarity to long-chain acyl-Coenzyme A dehydrogenase (rat Acadl), which catalyzes the first step in mitochondrial fatty acid beta-oxidation Isovaleryl-CoA dehydrogenase C02D5.2 C02D5.2 Protein with strong similarity to C. elegans ZK669.2 gene product C02D5.3 C02D5.3 Protein containing glutathione S-transferase N-terminal and C-terminal domains, has a region of high similarity to a region of glutathione S-transferase omega 1 (mouse Gsto1), which binds glutathione and functions as a stress response protein C02E11.1 C02E11.1 Putative ortholog of human pM5 protein (Hs.75663), a putative member of the collagenase gene family C02E7.1 C02E7.1 Member of the E1-E2 (P-type) ATPase family and the haloacid dehalogenase or epoxide hydrolase family, contains cation transporting ATPase N-terminal and C-terminal domains, has moderate similarity to alpha subunit of non-gastric H,K ATPase (human ATP12A) sodium/potassium-transporting ATPase alpha-2 chain C02E7.10 C02E7.10 Protein with strong similarity to C. elegans C24B9.9 gene product C02E7.13 C02E7.13 Member of the 7-transmembrane chemoreceptor family of G protein-coupled receptors (GPCR), has low similarity to C. elegans ODR-10, which is involved in odorant response 7TM chemoreceptor, str family C02E7.14 C02E7.14 Protein of unknown function, has high similarity to uncharacterized C. elegans T05F1.12 C02E7.2 C02E7.2 Protein of unknown function, has high similarity to uncharacterized C. elegans C02E7.4 7TM chemoreceptor, srh family C02E7.3 C02E7.3 Protein of unknown function, has high similarity to uncharacterized C. elegans C02E7.4 7TM chemoreceptor, srh family C02E7.4 C02E7.4 Member of the 7-transmembrane chemoreceptor family of G protein-coupled receptors (GPCR), has high similarity to uncharacterized C. elegans C02E7.5 7TM chemoreceptor, srh family C02E7.5 C02E7.5 Protein of unknown function, has high similarity to uncharacterized C. elegans C02E7.4 7TM chemoreceptor, srh family C02E7.6 C02E7.6 Protein of unknown function, has weak similarity to C. elegans C02E7.7 C02E7.7 C02E7.7 Protein of unknown function, has weak similarity to C. elegans C02E7.6 C02E7.8 C02E7.8 Protein of unknown function C02E7.9 C02E7.9 Member of the 7-transmembrane chemoreceptor family of G protein-coupled receptors (GPCR), has low similarity to C. elegans ODR-10, which is involved in odorant response 7TM chemoreceptor, str family C02F12.1 C02F12.1 Member of the tetraspanin family, which contain an N-terminal transmembrane domain that is a signal sequence and membrane anchor, has weak similarity to uncharacterized melanoma 1 antigen (mouse Cd63) transpanin C02F12.3 C02F12.3 Protein of unknown function C02F12.4 C02F12.4 Protein containing a RhoGEF (GTPase exchange factor) domain, has a region of low similarity to a region of FGD1 related F actin binding protein (rat frabin), which is an actin crosslinking protein that activates Cdc42, Rac (Akt) and Jun kinase (Serk2) guanine-nucleotide releasing factor of the CDC24 family C02F12.5 C02F12.5 Homeodomain transcription factor, has similarity over the homeodomain to many human and D. melanogaster homeodomain transcription factors homeobox; tissue factor pathway inhibitor C02F12.7 C02F12.7 Putative coiled-coil protein, has similarity to human CENPE, centromere protein E C02F12.8 C02F12.8 Protein of unknown function breast cancer type 1 susceptibility protein (BRCA1) C02F12.9 C02F12.9 Protein of unknown function C02F4.1 ced-5;C02F4.1 Protein required for cell corpse engulfment and distal tip cell migration DOCK180 protein; The ced-5 gene a homolog of the human protein DOCK180 that is required for the cell engulfment stage of programmed cell death. C02F4.2 PP2B;C02F4.2 Protein with high similarity to calcineurin A alpha (rat Ppp3ca), which is the catalytic subunit of calcium/calmodulin regulated protein phosphatase that regulates the activity of transcription factors, member of the serine or threonine phosphatase family serine/threonine protein phosphatase; tax-6 encodes an ortholog of calcineurin A that is required for inhibition and adaptation of several sensory neurons and for the normal regulation of egg-laying by serotonin; TAX-6 stimulates transcription of rcn-1, and binds RCN-1 protein if free Ca[2+] is present; in general, calcineurin positively regulates calcium-dependent signaling. C02F4.3 C02F4.3 Protein of unknown function C02F4.4 C02F4.4 Protein of unknown function C02F4.5 C02F4.5 Protein of unknown function C02F5.1 C02F5.1 Putative coiled-coil protein, has weak similarity to human early endosome antigen EEA1 knl-1 encodes a novel acidic protein with a coiled-coil region at its C-terminus; KNL-1 is an essential kinetochore component that is required for proper spindle elongation and chromosome separation, and in the kinetochore assembly pathway, plays a key role in linking the initiation of kinetochore formation with the construction of a functional microtubule-binding interface; in the assembly pathway, KNL-1 functions downstream of the DNA-proximal kinetochore components CeCENP-A/HCP-3 and CeCENP-B/HCP-4 and upstream of the outer kinetochore components HIM-10/Nuf2p, NDC-80/HEC1, CeBUB-1, HCP-1, and CeCLASP2/CLS-2; in expression studies in the one-cell embryo, KNL-1 localizes to kinetochores throughout mitosis. C02F5.10 C02F5.10 Protein with moderate similarity to C. elegans C02F5.2 gene product C02F5.11 C02F5.11 Protein with strong similarity to C. elegans C02F5.8 gene product tetraspanin C02F5.12 C02F5.12 Protein with strong similarity to C. elegans T07G12.13 gene product C02F5.2 C02F5.2 Protein with moderate similarity to C. elegans C02F5.10 gene product C02F5.3 C02F5.3 Putative GTP-binding protein GTP-binding protein; This gene encodes a protein predicted by Eisenberg and coworkers, with 52% accuracy, to be mitochondrial. C02F5.4 C02F5.4 Protein of unknown function, has weak similarity to uncharacterized human FLJ10656 C02F5.5 C02F5.5 Protein of unknown function, has high similarity to uncharacterized C. elegans F17E9.5 C02F5.6 C02F5.6 Protein of unknown function C02F5.8 C02F5.8 Member of the tetraspanin family, which contain an N-terminal transmembrane domain that is a signal sequence and membrane anchor, has moderate similarity to uncharacterized C. elegans C02F5.11 tetraspanin C02F5.9 pbs-6;C02F5.9 Putative beta-type subunit of 20S proteasome particle Proteasome component C5; The pbs-6 gene encodes a homolog of mammalian PSMB1. C02G6.1 C02G6.1 Member of the insulinase (peptidase M16) family, has moderate similarity to insulin-degrading enzyme (insulysin, rat Ide), which is a metallopeptidase that degrades insulin, amyloid beta (rat App), insulin-like growth factors, and natriuretic peptides peptidase; This gene encodes a protein predicted by Eisenberg and coworkers, with 68% accuracy, to be mitochondrial. C02G6.2 C02G6.2 Member of the insulinase (peptidase M16) family, has moderate similarity to insulin-degrading enzyme (receptor accessory factor, insulinase, human IDE), which is a peptidase that may have a role in sex differentiation peptidase; This gene encodes a protein predicted by Eisenberg and coworkers, with 68% accuracy, to be mitochondrial. C02H6.1 C02H6.1 Member of the galactosyltransferase family, which transfer galactose to GlcNAc termini of growing oligosaccharide chains, has high similarity to uncharacterized C. elegans F56H6.1 C02H6.2 C02H6.2 Protein containing an F-box domain, which serve as a link between a target protein and a ubiquitin-conjugating enzyme, and a DUF38 domain of unknown function, has low similarity to C. elegans FOG-2, which is required for the sexual identity of germ cells This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins; this gene's encoded protein also contains an FTH/DUF38 motif, which may also mediate protein-protein interaction. C02H7.1 C02H7.1 Putative coiled-coil protein, has weak similarity to myosin heavy chains C02H7.2 C02H7.2 Member of the rhodopsin family of G protein-coupled receptors (GPCR), has weak similarity to a region of central cannabinoid receptor 1 (human CNR1), which signals through an inhibitory G protein C02H7.3 aex-3;C02H7.3 Regulator of presynaptic activity related to the defecation cycle; putative ortholog of human MAP-kinase activating death domain protein MADD The aex-3 gene encodes a guanine nucleotide exchange factor for the rab-3 GTPase that is orthologous to human MAP kinase activating protein containing death domain (MADD, OMIM:603584); AEX-3 is required for intracellular vesicle trafficking as well as synaptic vesicle release and interacts with CAB-1 and RAB-3 to regulate separate pathways for neural activities such as defecation and male mating, respectively; AEX-3 is also required for egg laying and locomotion; AEX-3 is expressed in nearly all neurons. C03A3.1 C03A3.1 Protein of unknown function C03A3.2 C03A3.2 Protein of unknown function C03A3.3 C03A3.3 Member of the metallo-beta-lactamase family C03A7.1 C03A7.1 Protein of unknown function, has high similarity to uncharacterized C. elegans ZK228.2 C03A7.10 C03A7.10 Putative ortholog of C. elegans C03A7.9 gene product 7TM chemoreceptor, srt family C03A7.11 C03A7.11 Protein containing a UDP-glucoronosyl and UDP-glucosyl transferase domain, has weak similarity to olfactory UDP-glucuronosyltransferase (human UGT2A1), which catalyzes the glucuronidation of substrates including odorants, steroids, drugs, and carcinogens C03A7.12 C03A7.12 Protein containing a UDP-glucoronosyl and UDP-glucosyl transferase domain, which transfer glycosyl groups to small hydrophobic molecules C03A7.13 C03A7.13 Putative ortholog of C. elegans C03A7.11 gene product C03A7.14 C03A7.14 Protein containing ten uncharacterized DUF139 cysteine repeat domains, has very strong similarity to uncharacterized C. elegans C03A7.8 abu-8 encodes a transmembrane protein with a predicted signal sequence, a glutamine/asparagine-rich domain and multiple cysteine-rich repeats (DUF139); abu-8 expression is induced by blockage of the unfolded-protein response in the endoplasmic reticulum, and ABU-8 may help protect the organism from damage by improperly folded nascent protein. C03A7.2 C03A7.2 Protein of unknown function, has moderate similarity to uncharacterized C. elegans F07B7.2 C03A7.3 C03A7.3 Protein of unknown function, has high similarity to uncharacterized C. elegans C44C3.7 7TM chemoreceptor, srw family C03A7.4 C03A7.4 Protein containing nine uncharacterized DUF139 cysteine repeat domains, has very strong similarity to uncharacterized C. elegans C03A7.7 The protein product of this gene is predicted to contain a glutamine/asparagine (Q/N)-rich ('prion') domain, by the algorithm of Michelitsch and Weissman (as of the WS77 release of WormBase, i.e., in wormpep77). C03A7.5 C03A7.5 Member of the rhodopsin family of G protein-coupled receptors (GPCR), has high similarity to uncharacterized C. elegans C03A7.6 7TM chemoreceptor, srx family C03A7.6 C03A7.6 Protein of unknown function, has high similarity to uncharacterized C. elegans C03A7.5 7TM chemoreceptor, srx family C03A7.7 C03A7.7 Protein containing nine uncharacterized DUF139 cysteine repeat domains, has very strong similarity to uncharacterized C. elegans C03A7.4 abu-6 encodes a transmembrane protein with a predicted signal sequence, a glutamine/asparagine-rich domain and multiple cysteine-rich repeats (DUF139); abu-6 expression is induced by blockage of the unfolded-protein response in the endoplasmic reticulum, and ABU-6 may help protect the organism from damage by improperly folded nascent protein. C03A7.8 C03A7.8 Protein containing ten uncharacterized DUF139 cysteine repeat domains, has very strong similarity to uncharacterized C. elegans C03A7.14 abu-7 encodes a transmembrane protein with a predicted signal sequence, a glutamine/asparagine-rich domain and multiple cysteine-rich repeats (DUF139); abu-7 expression is induced by blockage of the unfolded-protein response in the endoplasmic reticulum, and ABU-7 may help protect the organism from damage by improperly folded nascent protein. C03A7.9 C03A7.9 Protein of unknown function, has high similarity to uncharacterized C. elegans T28A11.15 7TM chemoreceptor, srt family C03B1.1 C03B1.1 Protein of unknown function C03B1.10 C03B1.10 Protein of unknown function C03B1.12 lmp-1;C03B1.12 Protein of unknown function that appears to be a component of acidic and lysosomal-like C. elegans gut granules; has similarity to H. sapiens macrophage glycoprotein LAMP/CD68 lmp-1 encodes a protein with similarity to vertebrate lysosome-associated membrane proteins CD68, and appears to be the only protein in C. elegans that has a GYXX (phi) vertebrate lysosomal targeting sequence at its carboxy terminus; localized to the periphery of a large population of membrane bound organelles (granules) seen throughout the early embryos and restricted to the cells of the intestine during later stages. C03B1.13 C03B1.13 Protein with moderate similarity to C. elegans Y37A1A.3 gene product C03B1.14 C03B1.14 Putative ortholog of C. elegans C03B1.8 gene product C03B1.2 C03B1.2 Protein of unknown function C03B1.3 C03B1.3 Protein of unknown function, has weak similarity to C. elegans C03B1.4 C03B1.4 C03B1.4 Protein of unknown function, has weak similarity to C. elegans C03B1.3 transposase C03B1.5 C03B1.5 Protein containing two protein kinase domains, has low similarity to a region of serine-threonine kinase 24 (human STK24), which is a serine-threonine kinase that prefers manganese as a cofactor protein kinase C03B1.6 C03B1.6 Protein of unknown function C03B1.7 C03B1.7 Protein of unknown function C03B1.9 C03B1.9 Protein of unknown function C03B8.1 C03B8.1 Protein of unknown function C03B8.2 C03B8.2 Protein of unknown function, has strong similarity to uncharacterized C. elegans C04C3.4 C03B8.3 C03B8.3 Protein of unknown function C03B8.4 lin-13;C03B8.4 Part of the class B pathway that antagonizes vulval induction, member of the zinc finger, C2H2 type protein family Zinc finger; Gene Function : lin-13 encodes a large (2248-residue) nuclear protein with multiple zinc fingers of the C2H2 class and a LXCXE retinoblastoma protein-binding motif, that is required for survival through larval development and for negative regulation of vulval fates during postembryonic development. C03C10.1 kin-19;C03C10.1 Putative casein kinase 1, appears to regulate polarity of the EMS blastomere casein Kinase I; kin-19 encodes a serine/threonine kinase orthologous to human casein kinase I, alpha 1 (CSNK1A1, OMIM:600505); KIN-19 appears to be a component of the non-canonical Wnt signaling pathway that regulates endoderm formation in the early embryo; kin-19(RNAi) and mom-2(RNAi) enhance apr-1(RNAi), but not RNAi of each other. C03C10.2 C03C10.2 Protein containing a protein kinase domain, has a region of low similarity to a region of casein kinase 1 delta (rat Csnk1d), which is a serine/threonine protein kinase possibly involved in DNA repair serine/threonine kinase C03C10.3 C03C10.3 Has high similarity to ribonucleotide reductase subunit M2 (mouse Rrm2), which associates with mouse Rrm1 to yield an enzyme that reduces ribonucleotides to deoxyribonucleotides, member of the ribonucleotide reductase small chain family Ribonuclease-diphosphate reductase M2; This gene encodes a protein predicted by Eisenberg and coworkers, with 52% accuracy, to be mitochondrial. C03C10.4 C03C10.4 Protein with moderate similarity to C. elegans K03E6.7 gene product C03C10.5 C03C10.5 Protein of unknown function C03C10.6 C03C10.6 Protein of unknown function C03C11.1 C03C11.1 Protein containing a DUF236 domain of unknown function, has high similarity to uncharacterized C. elegans F27C1.3 C03C11.2 fog-3;C03C11.2 Protein required for the sexual identity of germ cells; has weak similarity to the H. sapiens Hs.79558 gene product C03D6.1 C03D6.1 Protein with moderate similarity to C. elegans C04F12.1 gene product C03D6.2 C03D6.2 Protein may be involved in RNA processing C03D6.3 cel-1;C03D6.3 Capping enzyme component with RNA 5'-triphosphatase and guanylyltransferase activity mRNA capping enzyme; cel-1 encodes a mRNA capping enzyme, with a N-terminal region with RNA triphosphatase activity and a C-terminal region containing motifs found in yeast and vaccinia virus capping enzyme guanylytransferases; cel-1 is required for embryonic viability, body morphology, and vulval development. C03D6.4 C03D6.4 Putative nucleoporin, has similarity to human nucleoporin NUP214 nucleoporin; npp-14 is orthologous to the human gene NUCLEOPORIN, 214-KD (NUP214; OMIM:114350), which encodes part of the nucleopore complex mediating nucleocytoplasmic transport; NUP214, as a fusion gene with DEK (OMIM:125264), is found in a subset of acute myeloid leukemia. C03D6.5 C03D6.5 Protein with low similarity to S. cerevisiae Asf1p, which is a component of replication-coupling chromatin assembly factor and a target of the S. cerevisiae Rad53p-dependent DNA damage response anti-silencing protein C03D6.6 C03D6.6 Protein of unknown function C03D6.8 C03D6.8 Protein with strong similarity to S. cerevisiae Ylr009p, a predicted ribosomal protein ribosomal protein; rpl-24.2 encodes a large ribosomal subunit L24 protein paralog; its orthologs include ribosomal protein L30 isologs from mammals and 'Ribosomal Like Protein 24' (Rlp24p) from S. cerevisiae; it therefore appears to actually represent an ancient paralogy between two varieties of eukaryotic L24 protein. C03E10.1 C03E10.1 Protein with strong similarity to C. elegans T03F7.6 gene product C03E10.2 C03E10.2 TcA transposase Tc1 transposase C03E10.3 C03E10.3 Protein of unknown function C03E10.4 mgat2;C03E10.4 Protein with moderate similarity to UDP-N-acetylglucosamine: alpha-6-D-mannoside-beta-1,2- N-acetylglucosaminyltransferase II (human MGAT2), which catalyzes the conversion of oligomannose to complex N-glycans UDP-GlcNAc:a-6-D-mannoside b1,2-N-acetylglucosaminyltransferase II; gly-20 is orthologous to the human gene MANNOSYL (ALPHA-1,6-)-GLYCOPROTEIN BETA-1,2-N-ACETYLGLUCOSAMINYLTRANSFERASE (MGAT2; OMIM:602616), which when mutated leads to carbohydrate-deficient glycoprotein syndrome, type II. C03E10.5 C03E10.5 Member of the C-type lectin family C03E10.6 C03E10.6 Protein with similarity to members of the C-type lectin family C03F11.1 C03F11.1 Member of the novel 6 TM potassium channel protein family noninactivating potassium channel (weak) C03F11.2 C03F11.2 Protein with moderate similarity to C. elegans C23H3.9 gene product C03F11.3 C03F11.3 Member of the CD36 family of putative scavenger receptors, has low similarity to CD36 antigen (human CD36), which is an integral membrane receptor that plays roles in cell adhesion, transport and receptor mediated functions glycoprotein C03F11.4 C03F11.4 Putative ortholog of C. elegans Y20C6A.3 gene product C03G5.1 C03G5.1 Protein with high similarity to succinate dehydrogenase complex subunit A (human SDHA), which is an electron transporter in the TCA cycle, contains a FAD binding domain and a fumarate reductase or succinate dehydrogenase flavoprotein C-terminal domain succinate dehydrogenase flavoprotein subunit; C03G5.1 is orthologous to the human gene SUCCINATE DEHYDROGENASE COMPLEX, SUBUNIT A, FLAVOPROTEIN (SDHA; OMIM:600857), which when mutated leads to complex II mitochondrial respiratory chain deficiency presenting as Leigh syndrome. C03G5.2 C03G5.2 Putative ortholog of C. elegans F42F12.6 gene product C03G5.7 flp-5;C03G5.7 Putative FMRF-amide neurotransmitters flp-5 encodes a predicted FMRFamide-like peptide neurotransmitter that increases action potential frequency in the pharyngeal muscle when applied to the pharynx of dissected worms; expressed in the sensory neurons ASE and PVM. C03G6.1 C03G6.1 Protein of unknown function, has low similarity to uncharacterized C. elegans K09D9.10 C03G6.10 C03G6.10 Protein containing two nuclear hormone receptor C4-type zinc finger domains, which bind DNA and may be involved in transcription regulation, and a nuclear hormone receptor ligand-binding domain, has weak similarity to C. elegans NHR-51 C4-type zinc finger protein C03G6.11 C03G6.11 Member of the 7-transmembrane chemoreceptor family of G protein-coupled receptors (GPCR), has high similarity to uncharacterized C. elegans F07C4.14 7TM chemoreceptor, srh family C03G6.12 C03G6.12 Protein containing a nuclear hormone receptor ligand-binding domain and a nuclear hormone receptor C4-type zinc finger domain, which bind DNA and may be involved in regulation of transcription, has weak similarity to mouse Nr6a1 C4-type zinc finger protein C03G6.13 C03G6.13 Protein containing a DUF18 domain of unknown function C03G6.14 C03G6.14 Member of the cytochrome P450 family, has low similarity to nicotine C-oxidase (cytochrome P450 2A6, human CYP2A6), which functions in oxidizing precarcinogens and drugs and may be associated with lung cancer risk C03G6.15 C03G6.15 Member of the cytochrome P450 family, has low similarity to cytochrome P450 subfamily IIC (mephenytoin 4-hydroxylase) polypeptide 8 (human CYP2C8), which is a heme-binding monooxygenase that metabolizes steroids, fatty acids, and xenobiotics cytochrome P450 C03G6.16 C03G6.16 Protein of unknown function, has moderate similarity to uncharacterized C. elegans Y62E10A.4 7TM chemoreceptor, srsx family C03G6.17 C03G6.17 Protein of unknown function, has high similarity to uncharacterized C. elegans T24A6.20 C03G6.18 C03G6.18 Member of the serpin family of serine protease inhibitors, has low similarity to serine (or cysteine) proteinase inhibitor (clade I (neuroserpin) member 2, human SERPINI2), which inhibits breast tumor metastasis serine protease inhibitor; srp-5 encodes an ovalbumin-like serpin (ov-serpin) member of the serine protease inhibitor superfamily; by homology, SRP-5 is predicted to function as a suicide substrate that inhibits the proteolytic activity of serine proteases; however, as loss of srp-5 function via RNA-mediated interference (RNAi) does not result in any obvious abnormalities, the precise role of SRP-5 in C. elegans development and/or behavior is not yet known. C03G6.19 C03G6.19 Member of the serpin family of serine protease inhibitors, has low similarity to squamous cell carcinoma antigen 2 (human SERPINB4), which inhibits chymotrypsin-like serine proteases and serves as a predictive marker for squamous cell carcinomas serine protease inhibitor C03G6.2 C03G6.2 Protein of unknown function, has high similarity to uncharacterized C. elegans K07C6.11 7TM chemoreceptor, srx family C03G6.20 C03G6.20 Putative ortholog of C. elegans ZK105.2 gene product C03G6.3 C03G6.3 Member of the 7-transmembrane chemoreceptor family of G protein-coupled receptors (GPCR), has low similarity to C. elegans ODR-10, which is a G protein-coupled receptor involved in odorant response 7TM chemoreceptor, srj family C03G6.4 C03G6.4 Protein containing two DUF19 domains of unknown function, which contain twelve conserved cysteines, has high similarity to uncharacterized C. elegans C36C5.1 C03G6.5 C03G6.5 Protein containing a DUF19 domain of unknown function, which contain twelve conserved cysteines, has high similarity to uncharacterized C. elegans C36C5.14 C03G6.6 C03G6.6 Member of the domain of unknown function DUF13 family, has high similarity to uncharacterized C. elegans C04F1.1 C03G6.7 C03G6.7 Member of the 7-transmembrane chemoreceptor family of G protein-coupled receptors (GPCR), has high similarity to uncharacterized C. elegans C32B5.2 7TM chemoreceptor, srh family C03G6.8 C03G6.8 Protein containing two nuclear hormone receptor C4-type zinc finger domains, which bind DNA and may be involved in transcription regulation, and a nuclear hormone receptor ligand-binding domain, has weak similarity to C. elegans NHR-51 C03G6.9 C03G6.9 Member of the 7-transmembrane chemoreceptor family of G protein-coupled receptors (GPCR), has high similarity to uncharacterized C. elegans F37B4.3 7TM chemoreceptor, srh family C03H12.1 C03H12.1 Putative ortholog of C. elegans ZK662.1 gene product C03H5.1 C03H5.1 Member of the C-type lectin family, has similarity to human C-type mannose receptor MRC1, has similarity to D. melanogaster TOLKIN protein C03H5.2 C03H5.2 Protein with high similarity to solute carrier family 35 (UDP-N-acetylglucosamine(UDP-GlcNAc) transporter) member 3 (human SLC35A3), which transports nucleotide sugars C03H5.3 C03H5.3 Protein of unknown function C03H5.4 C03H5.4 Member of the phospholipase A2 family, has a region of moderate similarity to a region of group IIA phospholipase A2 (rat Pla2g2a), which is a secreted phospholipase that hydrolyzes the phospholipid sn-2 ester bond and has a role in host defense phospholipase C03H5.5 C03H5.5 Protein with strong similarity to C. elegans C17G10.9 gene product C03H5.6 C03H5.6 Protein containing a BTB (BR-C, ttk and babor) or POZ (Pox virus and zinc finger) domain, which are found in some DNA and actin binding proteins and may mediate protein-protein interactions C03H5.7 C03H5.7 Protein with moderate similarity to C. elegans Y40H7A.9 gene product C04A11.1 C04A11.1 Protein of unknown function C04A11.2 C04A11.2 Protein of unknown function C04A11.3 C04A11.3 Protein containing a protein kinase domain, has low similarity to serine-threonine kinase 2 (mouse Stk2), which undergoes cleavage by caspase 3 (Casp3) during apoptosis thereby releasing an N-terminal kinase domain and a C-terminal domain serine/threonine kinase C04A11.4 adm-2;C04A11.4 Member of the reprolysin (M12B) zinc metalloprotease family, contains a disintegrin domain, has low similarity to meltrin alpha (mouse Adam12), which has cell adhesion and metalloproteinase activity and is involved in muscle cell differentiation zinc metalloprotease; adm-2 encodes a protein containing a snake venom disintegrin-domain and a metalloprotease-like domain (i.e., a protein of the ADAM family); like ADM-1, ADM-2 is homologous to a mammalian sperm glycoprotein (PH-30/fertilin) implicated in sperm-egg fusion, and ADM-2 might thus be a fusogenic protein mediating the merging of plasma membranes during development. C04A2.1 C04A2.1 Protein of unknown function, has weak similarity to S. cerevisiae Msb3p and Msb4p, multicopy suppressor of bud emergence mutants C04A2.3 egl-27;C04A2.3 Protein required for cell polarity and cell migration that is similar to a mammalian metastasis-associated factor egl-27 encodes a homolog of human MTA1, part of an ATP-dependent complex with nucleosome remodelling and histone deacetylation activities that may promote tumor metastasis; in conjunction with its paralog egr-1, egl-27 is required for proper organization in all parts of the embryo, and for the embryonic expression of hlh-8. C04A2.7 C04A2.7 Protein containing five DnaJ domains, which are part of chaperone (protein folding) system that mediates interaction with heat shock proteins, has a region of low similarity to a region of human DRIP78, which is a dopamine receptor interacting protein This gene encodes a protein containing a DnaJ ('J') domain. C04B4.1 C04B4.1 Putative ortholog of C. elegans B0513.1 gene product C04B4.2 C04B4.2 Protein of unknown function, has moderate similarity to uncharacterized C. elegans C04B4.4 C04B4.3 C04B4.3 Member of the class 2 lipase family, has high similarity to uncharacterized C. elegans F45E6.4 lipase C04B4.4 C04B4.4 Protein of unknown function, has moderate similarity to uncharacterized C. elegans C04B4.2 C04B4.5 C04B4.5 Protein of unknown function C04B4.6 C04B4.6 Protein of unknown function C04C11.1 C04C11.1 Protein of unknown function C04C11.2 C04C11.2 Protein with moderate similarity to C. elegans T12D8.4 gene product C04C11.3 C04C11.3 Protein with weak similarity to H. sapiens KIAA0464 (KIAA0464 gene product) C04C3.1 C04C3.1 Protein containing a DUF216 domain of unknown function, has low similarity to uncharacterized C. elegans Y102A5C.23 7TM chemoreceptor, srz family C04C3.2 C04C3.2 Protein containing a neurotransmitter-gated ion-channel ligand binding domain, has low similarity to acetylcholine receptor alpha 10 subunit (rat Chrna10), which plays a role in cholinergic signaling channel protein C04C3.3 C04C3.3 Protein with high similarity to E1 beta subunit of pyruvate dehydrogenase complex (human PDHB), which oxidatively decarboxylates pyruvate to acetyl-CoA, contains a transketolase pyridine binding domain and a transketolase C-terminal domain pyruvate dehydrogenase; This gene encodes a protein predicted by Eisenberg and coworkers, with 52% accuracy, to be mitochondrial. C04C3.4 C04C3.4 Protein of unknown function, has strong similarity to unchracterized C. elegans T07F10.5 C04C3.5 C04C3.5 Protein with strong similarity to human Hs.155995 gene product, cDNA KIAA0643 isolated from a brain cDNA library C04C3.6 C04C3.6 Protein of unknown function, has moderate similarity to uncharacterized C. elegans C50H11.13 C04C3.7 C04C3.7 Protein of unknown function, has a region of low similarity to a region of C. elegans ODR-10, which is a G protein-coupled receptor that is involved in odorant response C04E12.1 C04E12.1 Protein containing a DUF40 domain of unknown function, which contain four conserved cysteines, has high similarity to uncharacterized C. elegans C18B10.3 C04E12.10 C04E12.10 Protein of unknown function, has high similarity to uncharacterized C. elegans C17B7.5 C04E12.11 C04E12.11 Protein of unknown function, has a region of low similarity to a region of vitamin D-3 upregulated protein-1 (mouse Txnip), which is induced by oxidative stress and functions as an oxidative stress mediator by inhibiting thioredoxin activity C04E12.12 C04E12.12 Protein of unknown function, has a region of low similarity to a region of vitamin D-3 upregulated protein-1 (human TXNIP), which binds to and inhibits the activity of thioredoxin and may thereby contribute to cellular redox mechanisms C04E12.2 C04E12.2 Protein containing a DUF19 domain of unknown function, which contain twelve conserved cysteines, has moderate similarity to uncharacterized C. elegans C17B7.4 C04E12.3 C04E12.3 Protein of unknown function, has moderate similarity to uncharacterized C. elegans T20D4.4 C04E12.4 C04E12.4 Protein of unknown function, has high similarity to uncharacterized C. elegans C17D12.3 C04E12.5 C04E12.5 Protein of unknown function, has high similarity to uncharacterized C. elegans F35F10.4 C04E12.6 C04E12.6 Protein of unknown function, has high similarity to uncharacterized C. elegans F35F10.7 C04E12.7 C04E12.7 Protein with moderate similarity to plasma membrane phospholipid scramblase 1 (human PLSCR1), which mediates Ca2+-dependent movement of membrane phospholipids in activated, injured, or apoptotic cells and is a substrate of tyrosine kinase c-Abl C04E12.7 encodes a homolog of human scramblase (PLSCR1; OMIM:604170), which is activated by a rise of intracellular calcium, and which promotes the exposure of phosphatidylserine on the surface of cells undergoing activation, injury, or apoptosis; closely related paralogs of C04E12.7 include T22H2.5 and ZK1053.5. C04E12.8 C04E12.8 Protein of unknown function, has strong similarity to uncharacterized C. elegans F49C5.2 7TM chemoreceptor, srx family C04E12.9 C04E12.9 Protein containing two DUF40 domains of unknown function, which contain four conserved cysteines, has strong similarity to uncharacterized C. elegans F35F10.9 C04E6.10 C04E6.10 Protein of unknown function, has high similarity to uncharacterized C. elegans C04E6.9 7TM chemoreceptor, srd family C04E6.11 C04E6.11 Protein of unknown function C04E6.12 C04E6.12 Protein containing a trypsin inhibitor-like cysteine rich domain C04E6.2 C04E6.2 Protein of unknown function, has high similarity to uncharacterized C. elegans F58D7.1 7TM chemoreceptor, srsx family C04E6.3 C04E6.3 Protein of unknown function C04E6.4 C04E6.4 Protein of unknown function C04E6.5 C04E6.5 Member of the ubiquitin carboxyl-terminal hydrolase family 2, contains a ubiquitin carboxyl-terminal hydrolases family 2 domain, has weak similarity to ubiquitin specific protease 12 (ubiquitin hydrolyzing enzyme 1, human USP12) C04E6.6 grd-9;C04E6.6 Protein of unknown function, has weak similarity to C. elegans GRD-6 C04E6.7 C04E6.7 Member of the haloacid dehalogenase or epoxide hydrolase family, has a region of low similarity to a region of cytoplasmic epoxide hydrolase (mouse Ephx2), which metabolizes xenobiotic molecules and may play a role in blood pressure regulation C04E6.8 C04E6.8 Protein of unknown function C04E6.9 C04E6.9 Member of the 7-transmembrane chemoreceptor family of G protein-coupled receptors (GPCR), has high similarity to uncharacterized C. elegans C04E6.10 7TM chemoreceptor, srd family C04E7.1 C04E7.1 Protein of unknown function C04E7.2 C04E7.2 Protein of unknown function, has low similarity to uncharacterized C. elegans K02F6.7 C04E7.3 C04E7.3 Protein of unknown function, has weak similarity to C. elegans SDC-2, a protein involved in sex determination C04F1.1 C04F1.1 Member of the domain of unknown function DUF13 family, has high similarity to uncharacterized C. elegans C03G6.6 C04F1.2 C04F1.2 Protein containing four NHL repeats, which are often associated with RING finger and B-box motifs, has low similarity to peptidylglycine alpha-amidating monooxygenase (mouse Pam), which is a bifunctional enzyme that alpha-amidates neuroendocrine peptide C04F1.3 lim-7;Celim-7;C04F1.3 Protein containing two LIM domains, which may mediate protein-protein interactions and a homeobox domain, which are found in transcription factors, has moderate similarity to ISL1 transcription factor (human ISL1), which is associated with type 2 diabetes homeobox protein C04F12.1 C04F12.1 Protein containing a piwi domain, has weak similarity to uncharacterized C. elegans F20D12.1 C04F12.10 C04F12.10 Member of the M48 peptidase family of zinc metalloproteases, has moderate similarity to farnesylated proteins converting enzyme 1 (human ZMPSTE24), which is a zinc metalloprotease involved in the C-terminal CAAX processing of farnesylated proteins Zinc-binding metalloprotease domain; fce-1 encodes an ortholog of 'farnesylated-proteins converting enzyme 1' (FACE-1), and thus probably enables post-translational processing of proteins (such as LET-60/RAS) carrying a C-terminal CaaX motif; FCE-1 protein probably accounts for the EDTA-sensitive, tosylphenylalanylchloromethane-insensitive component of CaaX-proteolytic activity in membrane extracts from C. elegans, and FCE-1 can cleave a farnesylated peptide in vitro; the S. cerevisiae homolog of FCE-1 (Ste24p) cleaves the precursor of yeast a-factor mating pheromone after its farnesylated cysteine residue, and transgenic FCE-1 rescues a mating defect of mutant yeast lacking both the Ste24p and the Rce1p CaaX-proteases. C04F12.2 C04F12.2 Protein of unknown function, has very strong similarity to uncharacterized C. elegans Y38H6C.6 transposase C04F12.3 ikb-1;C04F12.3 Protein containing six ankyrin (Ank) repeats and a death domain, which may mediate protein-protein interactions, has a region of low similarity to a region of B cell CLL lymphoma 3 (human BCL3), which regulates the transcriptional activity of NF-kappa B Ank repeat; ikb-1 encodes an ortholog of human BCL3 (OMIM:109560) that physically interacts with the checkpoint protein MRT-2; ikb-1(nr2019) and ikb-1(nr2027) mutants display no obvious phenotype other than shortened lifespan; mutation of BCL3 is frequently associated with recurring translocations found in the neoplastic cells of patients with chronic lymphocytic leukemia, and has been implicated in cell cycle control (perhaps via apoptosis). C04F12.4 C04F12.4 Protein with high similarity to ribosomal protein L14 (S. cerevisiae Rpl14ap), which binds RNA and is a structural ribosomal protein, member of the ribosomal L14e family, which are part of the large ribosomal subunit rpl-14 encodes a large ribosomal subunit L14 protein. C04F12.5 C04F12.5 Protein of unknown function that may be anchored to the membrane of a secretory vesicle or the Golgi apparatus C04F12.6 C04F12.6 Protein containing a DUF236 domain of unknown function, has strong similarity to uncharacterized C. elegans K07A1.5 C04F12.7 C04F12.7 Protein of unknown function, has very strong similarity to uncharacterized C. elegans F41H10.1 C04F12.8 C04F12.8 Protein containing a dual specificity phosphatase catalytic domain, has low similarity to a region of MAPK phosphatase-7 (human MKP-7), which is a cytoplasmic protein phosphatase that preferentially inactivates human MAPK8 and human MAPK14 Dual specificity phosphatase, catalytic domain C04F12.9 C04F12.9 Member of the RNase H family, which digest the RNA strand of an RNA-DNA duplex, has low similarity to a region of ribonuclease H1 (mouse Rnaseh1), which binds to double stranded RNA and DNA-RNA hybrids and degrades RNA from DNA-RNA hybrids This gene encodes a protein predicted by Eisenberg and coworkers, with 52% accuracy, to be mitochondrial. C04F2.1 C04F2.1 Member of the 7-transmembrane chemoreceptor family of G protein-coupled receptors (GPCR), has high similarity to uncharacterized C. elegans W03F9.6 7TM chemoreceptor, srh family C04F2.4 C04F2.4 Member of the 7-transmembrane chemoreceptor family of G protein-coupled receptors (GPCR), has low similarity to uncharacterized C. elegans F37B4.6 7TM chemoreceptor, srh family C04F5.1 sid-1;C04F5.1 Protein with strong similarity to C. elegans R04E5.6 gene product The sid-1 gene encodes a predicted transmembrane protein with conserved human (OMIM:606816) and mouse homologs of unknown function and is required cell autonomously for systemic RNA interference (RNAi); a SID-1::GFP fusion is enriched at the cell periphery of most nonneuronal cells from late embryogenesis through adulthood with highest levels detected in cells exposed to the environment. C04F5.2 C04F5.2 Protein of unknown function, has weak similarity to C. elegans T10G3.2 C04F5.3 C04F5.3 Protein of unknown function unc-46 encodes a novel protein with a single predicted transmembrane domain; UNC-46 and UNC-47, a novel transmembrane vesicular GABA transporter, are required in GABAergic neurons for all GABA neurotransmission, specifically for loading of GABA into synaptic vesicles, where UNC-46 is localized; UNC-46 localization requires UNC-47, which when overexpressed can rescue unc-46 mutant animals. C04F5.4 C04F5.4 Member of the C. elegans Sre G protein-coupled chemoreceptor family, which are putative chemosensory receptors, has high similarity to uncharacterized C. elegans C04F5.5 7TM chemoreceptor, srab family C04F5.5 C04F5.5 Member of the C. elegans Sre G protein-coupled chemoreceptor family, which are putative chemosensory receptors, has high similarity to uncharacterized C. elegans C04F5.4 7TM chemoreceptor, srab family C04F5.6 C04F5.6 Member of the C. elegans Sre G protein-coupled chemoreceptor family, which are putative chemosensory receptors, has high similarity to uncharacterized C. elegans C04F5.4 7TM chemoreceptor, srab family C04F5.7 C04F5.7 Protein containing a UDP-glucoronosyl and UDP-glucosyl transferase domain, has weak similarity to bilirubin UDP-glucuronosyltransferase (rat UDPGT), which is a putative UDP-glucuronosyltransferase involved in bilirubin conjugation UDP-glucosyltransferase C04F5.8 C04F5.8 Protein of unknown function C04F5.9 C04F5.9 Protein containing six C2H2 type zinc finger domains, which bind nucleic acids, has a region of low similarity to a region of C. elegans SDC-1, which is involved in sex determination and dosage compensation C04F6.1 vit-5;C04F6.1 170 kDa yolk protein vit-5 encodes a vitellogenin, a lipid-binding protein precursor related to vertebrate vitellogenins and mammalian ApoB-100, a core LDL particle constituent; by homology, VIT-5 is predicted to function as a lipid transport protein; loss of vit-5 activity via large-scale RNA-mediated interference (RNAi) screens indicates that VIT-5 is required for embryogenesis and normal rates of postembryonic growth; VIT-5 is a major yolk component and is expressed exclusively in the adult hermaphrodite intestine from which it is secreted into the pseudocoelomic space and taken up by oocytes. C04F6.2 C04F6.2 Protein of unknown function C04F6.3 cht-1;CHT1;C04F6.3 Member of the glycosyl hydrolase 18 family, contains two chitin binding peritrophin-A domains, has moderate similarity to chitinase 1 (chitotriosidase, human CHIT1), which catalyzes the hydrolysis of chitin and is associated with Gaucher disease glycosyl hydrolase (family 18); cht-1 encodes a chitinase orthologous to human chitinase-1 (OMIM:600031, mutations are associated with chitotriosidase deficiency); CHT-1 is predicted to function as an extracellular O-glycosyl hydrolase that hydrolyzes the glycosidic bond between two or more carbohydrates; in C. elegans, CHT-1 may play a role in embryogenesis, and may also be required for cuticle degradation during molting and degradation of chitin-containing pathogens as part of a host defense mechanism. C04F6.4 unc-78;C04F6.4 Member of the WD repeat protein family; appears to be required for appropriate muscle structure beta transducin; The unc-78 gene encodes a homolog of actin-interacting protein 1 (AIP1) that regulates the ordered assembly of actin and cofilin in myofibrils. C04F6.5 C04F6.5 Member of the short-chain dehydrogenase-reductase family, which are NAD- or NADP-dependent oxidoreductases, contains a DUF 227 domain, has a region of moderate similarity to C. elegans DAZ-1, which is a meiotic factor required for oogenesis alcohol/ribitol dehydrogenase; dhs-27 encodes a short-chain dehydrogenase predicted to be mitochondrial. C04G2.1 C04G2.1 Member of the transthyretin-like family Transthyretin-like family C04G2.10 C04G2.10 Protein of unknown function, has a region of low similarity to a region of germ cell-specific gene 2 (haspin, mouse Gsg2), which is a serine-threonine kinase that binds DNA and may play roles in cell cycle cessation and haploid germ cell differentiation C04G2.11 C04G2.11 Protein containing a DUF41 domain of unknown function, has low similarity to uncharacterized C. elegans ZK355.5 C04G2.2 C04G2.2 Protein containing a protein kinase domain, has low similarity to a region of S. cerevisiae Hrr25p, which is a casein kinase I (serine/threonine/tyrosine protein kinase) involved in DNA repair and meiosis serine/threonine kinase C04G2.4 msp-36;C04G2.4 Member of the major sperm-specific protein (MSP) family major sperm protein; msp-36 encodes a protein that belongs to a family of proteins called the Major Sperm Proteins (MSPs) that is conserved in nematodes; this family comprises of closely related, small, basic proteins that make up 15% of sperm protein; this multigene family consists of over fifty genes, including many pseudogenes; MSP is involved in both extracellular signaling and cytoskeletal functions during reproduction-MSP antagonizes Eph/ephrin signaling, in part, by binding VAB-1 Eph receptor tyrosine kinase on oocytes and sheath cells to promote oocyte maturation and MAPK activation; MSP assembles into fibrous networks that drives movement of the C. elegans sperm; msp genes are expressed only in late primary spermatocytes. C04G2.5 C04G2.5 Protein with strong similarity to C. elegans B0457.4 gene product C04G2.6 C04G2.6 Member of the RNB-like family, which may have exonuclease activity, has moderate similarity to S. pombe Dis3p, which is an essential protein required for anaphase A mitotic events S.pombe mitotic control protein like C04G2.7 egl-38;lin-50;C04G2.7 Homeodomain transcription factor involved in regulation of lin-3 in vulval cells and in hindgut development, has similarity to many human and D. melanogaster homeodomain transcription factors Human paired box protein like; The egl-38 gene encodes a Pax5 homolog. C04G2.8 C04G2.8 Protein of unknown function, has strong similarity to uncharacterized C. elegans C10G11.9 C04G2.9 C04G2.9 Protein of unknown function, has strong similarity to uncharacterized C. elegans Y69E1A.B C04G6.1 C04G6.1 Protein containing two protein kinase domains, has moderate similarity to a region of mitogen activated protein kinase 7 (big mitogen activated protein kinase, mouse Mapk7), which interacts with MEK5 and is involved in EGF receptor signaling Ser/Thr protein kinase; mpk-2 encodes a mitogen activated protein (MAP) kinase; by homology, MPK-2 is predicted to function as a serine/threonine kinase that acts downstream of a receptor tyrosine kinase in a cell signaling pathway; however, as loss of mpk-2 activity via large-scale RNAi screens does not produce any obvious abnormalities, the precise role of MPK-2 in C. elegans development and/or behavior is not yet known. C04G6.10 C04G6.10 Protein with weak similarity to C. elegans C27A2.5 gene product C04G6.11 C04G6.11 Protein of unknown function C04G6.2 C04G6.2 Protein with strong similarity to C. elegans F54D10.9 gene product C04G6.3 C04G6.3 Putative phospholipase D, predicted to hydrolyze phosphatidylcholine to form phosphatidic acid and choline phospholipase D C04G6.4 C04G6.4 Protein of unknown function salt-stress induced peptide C04G6.5 C04G6.5 Member of the uncharacterized protein family UPF0057, has high similarity to uncharacterized C. elegans F47B7.1 salt-stress induced peptide C04G6.6 C04G6.6 Protein of unknown function C04G6.7 C04G6.7 Protein of unknown function, has high similarity to uncharacterized C. elegans C27A2.5 C04H5.1 C04H5.1 Protein of unknown function, has moderate similarity to uncharacterized human HSPC152 C04H5.2 C04H5.2 Protein containing a C-type lectin domain, which mediate calcium-dependent carbohydrate recognition, has moderate similarity to uncharacterized C. elegans EEED8.11 C04H5.3 C04H5.3 Protein containing a receptor family ligand binding domain C04H5.4 C04H5.4;C04H5.4 Protein containing two protein kinase domains and two adenylate and guanylate cyclase catalytic domains, has moderate similarity to a region of natriuretic peptide receptor A (mouse Npr1), which is a membrane-bound guanylate cyclase C04H5.6 mog-4;C04H5.6 Member of the RNA helicase, DEAH-box protein family Helicases conserved C-terminal domain; The mog-4 gene encodes a DEAH helicase orthologous to the Drosophila CG10689 and the S. cerevisiae PRP2 proteins. C04H5.7 C04H5.7 Protein of unknown function C05A2.1 C05A2.1 Member of the protein phosphatase protein family serine/threonine protein phosphatase C05A9.1 C05A9.1 Member of the ABC transporter family, which are involved in translocation across biological membranes, contains two ABC transporter transmembrane domains, has moderate similarity to C. elegans C47A10.1, which is a probable membrane transporter p-glycoprotein; pgp-5 encodes a transmembrane protein that is a member of the P-glycoprotein subclass of the ATP-binding cassette (ABC) transporter superfamily; by homology, PGP-5 is predicted to function as an ATP-dependent efflux pump that protects C. elegans by exporting exogenous toxins; however, as loss of pgp-5 activity via large-scale RNAi screens does not result in any obvious abnormalities, the precise role of PGP-5 in C. elegans development and/or behavior is not yet known. C05A9.2 C05A9.2 Protein of unknown function C05A9.3 C05A9.3 Protein containing three ankyrin (Ank) repeats, which may mediate protein-protein interactions ankyrin like C05B10.1 lip-1;C05B10.1 Putative dual-specificity protein phosphatase, involved in vulva cell fate specification protein-tyrosine phosphatase C05B10.2 C05B10.2 Protein of unknown function C05B5.1 C05B5.1 Protein of unknown function C05B5.2 C05B5.2 Putative ortholog of C. elegans C33F10.1 gene product C05B5.3 C05B5.3 Protein with weak similarity to S. cerevisiae NUP57 (Nuclear pore protein (nucleoporin) of the GLFG family) The protein product of this gene is predicted to contain a glutamine/asparagine (Q/N)-rich ('prion') domain, by the algorithm of Michelitsch and Weissman (as of the WS77 release of WormBase, i.e., in wormpep77). C05B5.4 C05B5.4 Protein of unknown function, has moderate similarity to uncharacterized C. elegans R10E12.2 C05B5.5 C05B5.5 Protein containing two EB module domains, and an F-box domain, which serves as a link between a target protein and a ubiquitin-conjugating enzyme, has a region of low similarity to a region of tenascin C (hexabrachion, human TNC) EGF repeats; This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins. C05B5.6 C05B5.6 Protein containing a DUF38 domain of unknown function C05B5.7 rgs-1;C05B5.7 Member of the regulator of G protein signaling domain protein family; modulates resumption of egg-laying after starvation 1r20 protein (human); rgs-1 encodes a regulator of G protein signaling; by homology, RGS-1 is predicted to function as a GTPase-activating protein for heterotrimeric G-protein alpha-subunits, and in vitro RGS-1 can stimulate the GTPase activity of purified GOA-1; in vivo, rgs-1 appears to function redundantly with rgs-2 to regulate egg-laying behavior when animals are refed following starvation; rgs-1 is expressed in most or all neurons. C05C10.1 C05C10.1 Member of the histidine acid phosphatase family, which hydrolyze phosphate esters at low pH, has low similarity to lysosomal acid phosphatase (rat Acp2), which is a tartrate-inhibitable lysosomal enzyme acid phosphatase C05C10.2 C05C10.2 Protein of unknown function, has a region of low similarity to a region of C. elegans SMG-2, which is involved in nonsense-mediated mRNA decay, mRNA surveillance, and RNAi-mediated gene suppression NAM7 protein C05C10.3 C05C10.3 Protein with high similarity to succinyl CoA:3-oxoacid CoA transferase (human OXCT), which acts in the conversion of acetoacetate to CoA and in ketone body metabolism and is associated with ketoacidosis, contains two coenzyme A transferase domains 3-oxoacid CoA-transferase; C05C10.3 is orthologous to the human gene 3-OXOACID COA TRANSFERASE (also called succinyl-CoA:3-ketoacid CoA transferase; OXCT; OMIM:245050), which when mutated leads to episodic ketoacidosis. C05C10.4 C05C10.4 Member of the histidine acid phosphatase family, which hydrolyze phosphate esters at low pH, has low similarity to lysosomal acid phosphatase (rat Acp2), which is a tartrate-inhibitable lysosomal enzyme acid phosphatase C05C10.5 C05C10.5 Protein of unknown function C05C10.6 C05C10.6 Protein containing ten WD domains (WD-40 repeat), which may mediate protein-protein interactions, has low similarity to phospholipase A2 activating protein (human PLAA), which may regulate phospholipase A2 activity and production of eicosanoids phospholipase activating protein C05C12.1 C05C12.1 Protein containing two protein kinase domains, has low similarity to S. pombe Cki1p, which is a casein kinase I serine/threonine kinase C05C12.3 C05C12.3 Member of the ion transport family, which include calcium, sodium, and potassium channels, has moderate similarity to C. elegans GON-2, which is a TRP channel protein that may mediate signal transduction for gonadal growth gtl-1 encodes a TRPM subfamily member of the TRP channel family that affects the periodicity of the defecation cycle in combination with gon-2; expression includes the intestine. C05C12.4 C05C12.4 Protein of unknown function C05C12.5 C05C12.5 Protein of unknown function C05C12.6 C05C12.6 Protein with weak similarity to C. elegans C39D10.6 gene product C05C8.1 C05C8.1 Protein of unknown function C05C8.2 C05C8.2 Putative ortholog of S. cerevisiae Krr1p, an essential protein of unknown function C05C8.3 dao-1;C05C8.3 Member of the FKBP-type peptidyl-prolyl cis-trans isomerase family, has low similarity to a region of FK506 binding protein 9 (mouse Fkbp9), which binds calcium and whose peptidyl prolyl isomerase activity is inhibited by binding to FK506 FKBP-binding protein; fkb-3 encodes a peptidylprolyl cis/trans isomerase homologous to mammalian FK506 immunosuppressant-binding protein 9; FKB-3 expression is positively regulated by signaling through the DAF-2 insulin receptor-like pathway and the activity of the DAF-16 fork-head transcription factor suggesting that FKB-3 could play a role in metabolism and longevity; however, as loss of FKB-3 function via RNA-mediated interference (RNAi) does not result in any abnormalities, the precise role of FKB-3 in C. elegans development and/or behavior is not yet known; FKB-3 contains a predicted endoplasmic reticulum (ER) retention sequence and is thus proposed to localize to the ER. C05C8.4 C05C8.4 Protein of unknown function, has weak similarity to human Hs.198760 and Hs.75735 heavy neurofilament subunit C05C8.5 C05C8.5 Member of the exonuclease family, has a region of low similarity to a region of ribonuclease H (S. cerevisiae RNH70), which is a 70 kDa endonuclease that degrades RNA in RNA-DNA hybrids C05C8.6 C05C8.6 Protein containing a BTB (BR-C, ttk and babor) or POZ (Pox virus and zinc finger) domain, which are found in some DNA and actin binding proteins, has a region of low similarity to a region of kelch-like 2 (Mayven, human KLHL2) C05C8.7 C05C8.7 Member of the phosphomannose isomerase type I family, has moderate similarity to phosphomannose isomerase (human MPI), which supplies D-mannose derivatives for glycosylation reactions and is associated with congenital disorders of glycosylation type Ib mannose-6-phosphate isomerase C05C8.8 C05C8.8 Protein containing a DUF138 domain of unknown function, has high similarity to uncharacterized C. elegans T06A1.1 C05C8.9 C05C8.9 Protein of unknown function C05C9.1 C05C9.1 Protein containing lipopolysaccharide-binding protein, bactericidal permeability-increasing protein or cholesteryl ester transfer protein N-terminal and C-terminal domains, has weak similarity to lipopolysaccharide-binding protein (mouse Lbp) LBP / BPI / CETP family C05C9.2 C05C9.2 Protein of unknown function C05C9.3 C05C9.3 Protein of unknown function NUM-1 like protein; The protein product of this gene is predicted to contain a glutamine/asparagine (Q/N)-rich ('prion') domain, by the algorithm of Michelitsch and Weissman (as of the WS77 release of WormBase, i.e., in wormpep77). C05D10.1 C05D10.1 Protein of unknown function C05D10.2 C05D10.2 Protein with high similarity to extracellular signal-regulated kinase 7 (rat ERK7), which is a protein serine-threonine kinase that inhibits cell proliferation and may regulate intracellular chloride channels, contains a protein kinase domain C05D10.3 C05D10.3 Member of the ABC transporter family, which are involved in translocation across biological membranes, has low similarity to ATP-binding cassette subfamily G member 1 (mouse Abcg1), which is an ABC transporter involved in cellular sterol homeostasis C05D10.4 C05D10.4 Protein containing two SAM (sterile alpha motif) domains, which may mediate protein-protein interactions C05D11.1 C05D11.1 Member of the insulinase (proteinase M16) protein family C05D11.10 MRPS17;C05D11.10 Possible ribosomal small subunit protein of the mitochondrion C05D11.11 mel-32;C05D11.11 Putative serine hydroxymethyltransferase C05D11.12 let-721;C05D11.12 Protein with high similarity to electron-transferring-flavoprotein dehydrogenase (human ETFDH), which is an electron acceptor for the mitochondrial matrix electron-transfer flavoprotein and reduces ubiquinone in the mitochondrial membrane YAAS; The let-721 gene encodes an ortholog of the human gene SIMILAR TO ELECTRON-TRANSFERRING-FLAVOPROTEIN DEHYDROGENASE (ETFDH), which when mutated leads to glutaricaciduria type IIC (OMIM:231675). C05D11.13 C05D11.13 Putative coiled-coil protein, has weak similarity to human trichohyalin ( Hs.82276), an intermediate filament-associated protein C05D11.2 C05D11.2 Protein of unknown function, has a region of weak similarity to a region of S. cerevisiae Vps16p, which is a vacuolar sorting protein C05D11.3 C05D11.3 Protein of unknown function, has moderate similarity to uncharacterized human APACD C05D11.4 let-756;ceFGF;C05D11.4 Member of the fibroblast growth factor protein family, has a region of moderate similarity to a region of fibroblast growth factor 9 (mouse Fgf9), which is a secreted growth-promoting factor heparin-binding gf; let-756 encodes an fibroblast growth factor (FGF)-like ligand that is required for progression through early larval development; LET-756 is expressed from late embryogenesis to adulthood, with a peak of expression in larvae; with EGL-17, LET-756 is redundantly required to activate EGL-15/FGFR, which in turn activates protein degradation in adult muscle cells; homozygotes for partial loss-of-function alleles are small, clear, and scrawny, but viable, while those for a null allele arrest in early larval development. C05D11.5 C05D11.5 Protein with strong similarity to D. melanogaster GIP glyoxylate-induced protein C05D11.6 C05D11.6 Member of the astacin (M12A) family of metalloproteases, has a region of moderate similarity to a region of the beta subunit of meprin A (rat Mep1b), which is an integral membrane protein that may play a role in embryogenesis zinc metalloprotease; nas-4 encodes a predicted extracellular matrix metalloprotease of the M12A (astacin) family that contains an N-terminal signal sequence and a catalytic domain, but no recognizable regulatory domains in the C-terminus; as loss of nas-4 activity via RNAi results in no obvious abnormalities, the precise role of NAS-4 in C. elegans development and/or behavior is not yet known; however, an NAS-4 translational reporter is expressed in the pharynx and intestine in larvae and adults, suggesting a role for NAS-4 in digestion; NAS-4 is specifically detected within cells of the pharyngeal procorpus, metacorpus, isthmus, and terminal bulb, with extracellular expression detected in the lumen of the terminal bulb and in the gut. C05D11.7 C05D11.7 Protein with strong similarity to C. elegans D1054.1 gene product C05D11.8 C05D11.8 Protein of unknown function C05D11.9 C05D11.9 Protein of unknown function C05D12.1 C05D12.1 Protein with moderate similarity to C. elegans dao-2 gene product C05D12.2 C05D12.2 Protein of unknown function, has high similarity to uncharacterized C. elegans Y19D10B.4 EGF domains C05D12.4 C05D12.4 Putative coiled-coil protein, has weak similarity to myosin heavy chains C05D12.5 C05D12.5 Putative coiled-coil protein, has weak similarity to S. cerevisiae Uso1p C05D2.1 daf-4;C05D2.1 Tpe II receptor kinase; involved in regulation of dauer formation, body size, and male tail development daf-4 encodes a transmembrane serine/threonine kinase that is the sole C. elegans ortholog of the type II transforming growth factor-beta (TGF-b) receptors; DAF-4 activity is required for several biological processes, including entry into and exit from the dauer larval stage, body size determination, male tail patterning, egg laying, chemosensory neuron specification, and increased thermotolerance; in regulating dauer larval development, DAF-4 acts in parallel with the insulin signaling pathway and likely partners with the DAF-1 type I TGF-b receptor to receive a signal from the DAF-7 TGF-b ligand; in body size determination and male tail patterning, DAF-4 likely partners with the SMA-6 type I receptor and responds to signals from the DBL-1 ligand; DAF-4 expression begins in late embryogenesis and continues through larval and adult stages; consistent with its role in many developmental processes, DAF-4 localizes to the plasma membrane of several tissues including head and tail neurons, the pharynx, intestine, ventral nerve cord, tail hypodermis, and body wall muscle. C05D2.10 C05D2.10 Protein with strong similarity to C. elegans lin-23 gene product C05D2.3 C05D2.3 Protein containing two pyridoxal-dependent group II decarboxylase conserved domains, which bind pyridoxal-phosphate groups, has moderate similarity to dopa decarboxylase (aromatic L-amino acid decarboxylase, rat Ddc) aromatic-L-amino-acid decarboxylase C05D2.4 C05D2.4 Protein containing two pyridoxal-dependent group II decarboxylase conserved domains, which bind pyridoxal-phosphate groups, has moderate similarity to dopa decarboxylase (aromatic L-amino acid decarboxylase, mouse Ddc) aromatic-L-amino-acid decarboxylase; bas-1 encodes a serotonin- and dopamine-synthetic aromatic amino acid decarboxylase (AAADC) that is required for the synthesis of serotonin from 5-hydroxytryptophan in vivo; mutations of bas-1 impair the turning step in male mating, the migration of AVM, SDQR, ALM, and BDU neurons during development. C05D2.5 C05D2.5 Protein involved in germ cell development gak-1 encodes a protein that contains an AT hook motif, a DNA-binding domain that shows a preference for binding stretches of A/T base pairs; GAK-1 appears to play a role in meiotic chromosome segregation, as overexpression results in post-prophase I chromosome segregation abnormalities, and a corresponding increase in embryonic lethality and the proportion of genotypically XO males in an otherwise self-fertile, XX hermaphrodite population; loss of gak-1 function via RNA-mediated interference (RNAi) results in sterility in the injected hermaphrodites, suggesting a possible role in germline development as well; gak-1 expression is enhanced in the germline, although its precise subcellular localization has not been reported. C05D2.6 C05D2.6 Member of the WD repeat protein family C05D2.6 encodes an unfamiliar protein, with no known non-nematode homologs, that specifically binds GOA-1 in yeast two-hybrid assays; C05D2.6 is expressed in several head and tail neurons, pharyngeal muscle, intestine, distal tip cell of the gonad, with weak expression in the ventral nerve cord; C05D2.6 is required for fertility in RNAi assays, with a phenotype of either sterile progeny or reduced brood size for C05D2.6(RNAi) in an rrf-3 mutant background. C05D2.8 C05D2.8 Putative ortholog of C. elegans C05D2.7 gene product C05D9.1 SNX1;C05D9.1 Protein containing a phox protein (PX) domain, which bind phosphoinositides, has moderate similarity to sorting nexin 1 (human SNX1), which may function in intracellular trafficking of receptors to various organelles, including endosomes and lysosomes C05D9.2 C05D9.2 Protein of unknown function, has weak similarity to human LAMP2 (lysosomal-associated membrane protein 2) C05D9.3 C05D9.3 Protein with moderate similarity integrin cell-surface receptors that may be anchored to the membrane of a secretory vesicle or the Golgi apparatus C05D9.4 C05D9.4 Protein of unknown function C05D9.5 ife-4;C05D9.5 Putative translation initiation factor eIF4E, binds to the mRNA cap structure initiation factor 4E (EIF-4E); The ife-4 gene encodes a member of the Initiation Factor 4E (eIF4E) family. C05D9.7 C05D9.7 Protein of unknown function C05D9.8 C05D9.8 Protein containing a von Willebrand factor (vWF) type A domain C05D9.9 C05D9.9 Protein of unknown function C05E11.1 C05E11.1 Protein of unknown function C05E11.2 C05E11.2 Protein of unknown function C05E11.3 C05E11.3 Protein of unknown function, has weak similarity to C. elegans F56C11.5 C05E11.4 C05E11.4 Member of the ammonium transporter family of membrane transporters, has low similarity to S. cerevisiae Mep1p, which is an ammonia permease of high capacity and moderate affinity ammonium transporter; amt-1 encodes a transmembrane transporter that by homology, is predicted to transport ammonium ions across the plasma membrane; as loss of amt-1 activity via large-scale RNAi screens does not result in any obvious abnormalities, the precise role of AMT-1 in C. elegans development and/or behavior is not yet known. C05E11.5 C05E11.5 Member of the ammonium transporter family of membrane transporters, has low similarity to S. cerevisiae Mep3p, which is an ammonia permease of high capacity and low affinity ammonium transporter; amt-4 encodes a member of the ammonium transporter protein family. C05E11.6 C05E11.6 Protein of unknown function C05E11.7 C05E11.7 Protein of unknown function, has moderate similarity to C. elegans T14E8.3 C05E11.8 flp-12;C05E11.8 Putative FMRF-amide neurotransmitter flp-12 encodes a predicted FMRFamide-like peptide neurotransmitter that affects locomotion when injected into A. suum; expressed in the ASE and PVM sensory neurons. C05E4.1 C05E4.1 Member of the serpin family of serine protease inhibitors, has low similarity to serine proteinase inhibitor class I member 1 (neuroserpin, mouse Serpini1), which inhibits plasmin, plasminogen activator, urokinase and may function in synaptic plasticity serine protease inhibitor; srp-2 encodes an ovalbumin-like serpin (ov-serpin) member of the serine protease inhibitor superfamily that is orthologous to human NEUROSERPIN (OMIM:602445, mutated in familial encephalopathy with neuroserpin inclusion bodies); SRP-2 is predicted to function as a suicide substrate that inhibits the proteolytic activity of serine proteases, and in vitro, recombinant SRP-2 is able to inhibit granzyme B activity; however, as loss of srp-2 function via RNA-mediated interference (RNAi) does not result in any obvious abnormalities, the precise role of SRP-2 in C. elegans development and/or behavior is not yet known; srp-2 expression is detected in hypodermal cells, particularly in the lateral seam cells. C05E4.10 C05E4.10 Member of the 7-transmembrane chemoreceptor family of G protein-coupled receptors (GPCR), has strong similarity to uncharacterized C. elegans C05E4.11 7TM chemoreceptor, srj family C05E4.11 C05E4.11 Member of the 7-transmembrane chemoreceptor family of G protein-coupled receptors (GPCR), has strong similarity to uncharacterized C. elegans C05E4.10 7TM chemoreceptor, srj family C05E4.12 C05E4.12 Protein of unknown function, has a region of low similarity to a region of C. elegans PHA-1, which is involved in pharyngeal development C05E4.13 C05E4.13 Member of the 7-transmembrane chemoreceptor family of G protein-coupled receptors (GPCR), has weak similarity to C. elegans ODR-10, which is a G protein-coupled receptor involved in odorant response 7TM chemoreceptor, str family C05E4.14 C05E4.14 Protein of unknown function, has strong similarity to C. elegans K09D9.7 7TM chemoreceptor, srh family C05E4.2 C05E4.2 Member of the 7-transmembrane chemoreceptor family of G protein-coupled receptors (GPCR), has low similarity to C. elegans ODR-10, which is a G protein-coupled receptor involved in odorant response 7TM chemoreceptor, str family C05E4.3 C05E4.3 Member of the serpin family of serine protease inhibitors, has low similarity to squamous cell carcinoma antigen 2 (mouse Scca2), which inhibits chymotrypsin-like serine proteases serine protease inhibitor; srp-1 encodes an ovalbumin-like serpin (ov-serpin) member of the serine protease inhibitor superfamily; by homology, SRP-1 is predicted to function as a suicide substrate that inhibits the proteolytic activity of serine proteases; however, as loss of srp-1 function via RNA-mediated interference (RNAi) does not result in any obvious abnormalities, the precise role of SRP-1 in C. elegans development and/or behavior is not yet known. C05E4.4 C05E4.4 Protein of unknown function, has low similarity to uncharacterized C. elegans F15H9.2 7TM chemoreceptor, sri family C05E4.6 C05E4.6 Member of the 7-transmembrane chemoreceptor family of G protein-coupled receptors (GPCR), has low similarity to C. elegans ODR-10, which is a G protein-coupled receptor involved in odorant response 7TM chemoreceptor, str family C05E4.7 C05E4.7 Protein of unknown function C05E4.8 C05E4.8 Protein with high similarity to C. elegans C01B12.6, which is a transposase, member of the transposase family, which are required for excising and inserting mobile genetic elements, contains a retroviral integrase core domain transposase C05E4.9 C05E4.9 Putative ortholog of S. cerevisiae MLS1 gene product (Malate synthase 1, functions in glyoxylate cycle, has near identity to Dal7p) isocitrate lyase; gei-7 encodes a predicted isocitrate lyase/malate synthase, an enzyme known to function in the glyoxylate cycle; GEI-7 was identified in a screen for proteins that interact with GEX-3, a homolog of human HEM-2 which is required for embryonic development; GEI-7 is required for embryonic morphogenesis and appears to act downstream of DAF-16 to influence lifespan. C05E7.1 C05E7.1;C05E7.1 Protein of unknown function, has low similarity to uncharacterized C. elegans C05E7.2 C05E7.2 C05E7.2 Protein of unknown function, has low similarity to uncharacterized C. elegans C05E7.1 C05E7.3 C05E7.3 Protein of unknown function C05E7.4 C05E7.4 Protein of unknown function, has low similarity to uncharacterized C. elegans K07E8.5 C05E7.5 VF11C1L.1;C05E7.5 Protein with strong similarity to S. cerevisiae Fab1p, a phosphatidylinositol-3-phosphate 5-kinase involved in orientation or separation of mitotic chromosomes C05G5.1 C05G5.1 Member of an uncharacterized protein family C05G5.2 C05G5.2 Protein of unknown function, has weak similarity to C. elegans C50F2.2 C05G5.3 C05G5.3 Protein of unknown function C05G5.4 C05G5.4 Protein with high similarity to succinyl-CoA synthetase alpha subunit (rat Suclg1), which catalyzes formation of succinyl-CoA in the tricarboxylic acid cycle, member of the ATP-citrate lyase or succinyl-CoA ligase family, contains one CoA binding domain succinyl-CoA synthetase; This gene encodes a protein predicted by Eisenberg and coworkers, with 68% accuracy, to be mitochondrial. C05G5.5 C05G5.5 Protein of unknown function C05G6.1 C05G6.1 Protein containing a nuclear hormone receptor ligand-binding domain C05G6.2 nhr-76;C05G6.2 Protein containing a nuclear hormone receptor C4-type zinc finger domain, which bind DNA and may be involved in transcription regulation, has moderate similarity to a region of rat Nr3c1, which is a hormone-dependent transcription factor C05H8.1 CaM-KK;C05H8.1 Calcium and calmodulin-dependent protein kinase kinase" ckk-1 encodes a calcium and calmodulin-dependent protein kinase kinase family member that affects CRE-dependent transcription in neurons. C05H8.2 C05H8.2 Protein of unknown function C06A1.1 C06A1.1 Member of the ATPases associated with various cellular activities (AAA) family transitional endoplasmic reticulum ATPase homolog 1 (P97 protein) C06A1.2 C06A1.2 Protein of unknown function C06A1.3 C06A1.3 Member of the protein phosphatase protein family serine/threonine protein phosphatase C06A1.4 C06A1.4 Protein containing a piwi domain and a PAZ (Piwi, Argonaut and Zwille) domain, which may mediate protein-protein interactions, has strong similarity to uncharacterized C. elegans F58G1.1 C06A1.5 C06A1.5 Protein with high similarity to a shared subunit of RNA polymerases I, II, and III (ABC23, S. cerevisiae Rpo26p), member of the RNA polymerases K 14-18 Kd subunit family, which are shared among all three types of eukaryotic RNA polymerases DNA directed RNA polymerase C06A1.6 C06A1.6 Protein of unknown function C06A12.3 C06A12.3 Protein of unknown function, has moderate similarity to uncharacterized C. elegans Y43F8B.2 C06A12.4 gcy-27;C06A12.4 Protein containing two protein kinase domains and an adenylate and guanylate cyclase catalytic domain, has high similarity to a region of C. elegans GCY-10, which is a putative guanylyl cyclase expressed in neurons and involved in chemosensation guanylate cyclase (2 domains) C06A12.5 C06A12.5 Protein of unknown function, has moderate similarity to uncharacterized C. elegans ZK945.1 C06A5.1 C06A5.1 Protein of unknown function C06A5.10 C06A5.10 Protein with strong similarity to C. elegans Y76G2A.2 gene product C06A5.11 C06A5.11 Protein with moderate similarity to C. elegans sir-2.1 gene product C06A5.2 C06A5.2 Protein of unknown function C06A5.4 C06A5.4 Putative ortholog of C. elegans Tc8.1 gene product C06A5.6 C06A5.6 Protein of unknown function, has moderate similarity to uncharacterized C. elegans ZK856.12 C06A5.7 C06A5.7 Protein with moderate similarity to tropomodulin (human TMOD), which is a putative capping protein of the actin thin filament pointed end and integral component of the cytoskeletal lattice that regulates cell adhesion and may regulate thin filament length tropomodulin; tmd-1 encodes a predicted member of the tropomodulin family and affects egg laying, locomotion, and muscle organization in one analysis using RNAi. C06A5.8 C06A5.8 Protein containing a C3HC4 type RING zinc finger, which may mediate protein-protein interactions C06A5.9 C06A5.9 Protein containing a C3HC4 type RING zinc finger, which may mediate protein-protein interactions C06A6.1 C06A6.1 Protein of unknown function C06A6.2 C06A6.2 Protein of unknown function C06A6.3 C06A6.3 Protein of unknown function C06A6.4 C06A6.4 Member of the M20, M25, or M40 peptidase family of zinc metalloproteases, has moderate similarity to aminoacylase 1 (human ACY1), which catalyzes the hydrolysis of N-alpha-acylated amino acids and may contribute to small cell lung cancer development aminoacylase-1 C06A6.5 C06A6.5 Member of the thioredoxin family, has weak similarity to a region of intestinal calcium binding protein (mouse Cai), which is an endoplasmic reticulum protein that has cysteine-type peptidase activity C06A8.1 C06A8.1 Member of the methylenetetrahydrofolate reductase family, which may be associated with hyperhomocysteinemia, has moderate similarity to 5',10'-methylenetetrahydrofolate reductase (human MTHFR), which catalyzes the conversion of methylenetetrahydrofolate C06A8.1 is orthologous to human MSH HOMEO BOX HOMOLOG 1 (MTHFR; OMIM:142983, mutated in homocystinuria). C06A8.2 C06A8.2 Protein of unknown function, has low similarity to uncharacterized C. elegans Y39E4B.2 C06A8.3 C06A8.3 Protein containing a DUF148 domain of unknown function, has high similarity to uncharacterized C. elegans ZK970.7 17k antigen (O. volvulus) C06A8.4 skr-17;C06A8.4 Protein with similarity to D. melanogaster skpA, a protein containing an ATP/GTP-binding site motif A skr-17 encodes a homolog of Skp1 in S. cerevisiae, a core component of the SCF (Skp1p, Cullin, F-box) ubiquitin-ligase complex that facilitates ubiquitin-mediated protein degradation; SKR-17 has no known function in vivo, since skr-17(RNAi) animals are at least superficially normal, and SKR-17 does not appear to interact in vitro with any of the C. elegans cullin homologs. C06A8.5 C06A8.5 Protein with weak similarity to myosin heavy chains of human, D. melanogaster and S. cerevisiae C06A8.6 C06A8.6 Protein containing seven leucine rich repeats, which mediate protein-protein interactions, has moderate similarity to S. pombe Sds22p, which is a protein phosphatase PP1 regulatory subunit required for chromosome disjunction during mitosis C06A8.7 C06A8.7 Member of the 7-transmembrane chemoreceptor family of G protein-coupled receptors (GPCR), has low similarity to uncharacterized C. elegans W02H5.6 7TM chemoreceptor, srh family C06A8.8 C06A8.8 Protein of unknown function C06A8.9 glr-4;C06A8.9 Protein containing a ligand-gated ion channel domain, has low similarity to glutamate receptor ionotropic kainate-selective 2 (human GRIK2), which is a ligand-gated ion channel subunit that plays a role in excitatory neurotransmission Glutamate receptor C06B3.1 C06B3.1 Member of the 7-transmembrane chemoreceptor family of G protein-coupled receptors (GPCR), has high similarity to uncharacterized C. elegans K02H11.3 G-protein coupled receptor C06B3.10 C06B3.10 Member of the 7-transmembrane chemoreceptor family of G protein-coupled receptors (GPCR), has low similarity to C. elegans ODR-10, which is a G protein-coupled receptor involved in odorant response C06B3.11 C06B3.11 Protein with strong similarity to C. elegans T10C6.3 gene product C06B3.2 C06B3.2 Member of the uncharacterized protein family UPF0063, has high similarity to uncharacterized C. elegans F36G9.12 C06B3.3 C06B3.3 Member of the cytochrome P450 family, has low similarity to cytochrome P450 2j4 (rat Cyp2j4), which is a monooxygenase that converts arachidonic acid to hydroxyeicosatetraenoic and epoxyeicosatrienoic acids cytochrome P450 C06B3.4 C06B3.4 Member of the short-chain dehydrogenase-reductase family, which are oxidoreductases, has moderate similarity to hydroxysteroid 17-beta dehydrogenase type 3 (human HSD17B3), which preferentially converts androstenedione to testosterone in the testis estradiol 17 beta-dehydrogenase; This gene encodes a protein predicted by Eisenberg and coworkers, with 68% accuracy, to be mitochondrial. C06B3.5 C06B3.5 Member of the short-chain dehydrogenase-reductase family, which are NAD- or NADP-dependent oxidoreductases, has moderate similarity to hydroxysteroid 17-beta dehydrogenase type III (rat Rn.10895), which converts androstenedione to testosterone estradiol 17 beta-dehydrogenase; This gene encodes a protein predicted by Eisenberg and coworkers, with 68% accuracy, to be mitochondrial. C06B3.6 C06B3.6 Protein of unknown function, has high similarity to uncharacterized C. elegans F13A7.11 C06B3.7 C06B3.7 Protein of unknown function, has low similarity to uncharacterized C. elegans F17C11.11 C06B3.8 gcy-32;C06B3.8 Putative soluble guanylyl cyclase guanylate cyclase; gcy-32 encodes a predicted guanylate cyclase; expressed in URX, AQR, and PQR neurons. C06B3.9 C06B3.9 Member of the 7-transmembrane chemoreceptor family of G protein-coupled receptors (GPCR), has high similarity to uncharacterized C. elegans C06B3.10 C06B8.1 C06B8.1 Protein containing a nuclear hormone receptor ligand-binding domain, has weak similarity to hepatocyte nuclear factor 4 gamma (human HNF4G), which is involved in differential transcriptional regulation of HNF4-dependent genes zinc finger protein C06B8.2 C06B8.2 Protein containing two DUF235 domains of unknown function, has high similarity to uncharacterized C. elegans Y45G12C.1 C06B8.3 C06B8.3 Putative ortholog of C. elegans F26D2.15 gene product dehydrogenase; This gene encodes a protein predicted by Eisenberg and coworkers, with 68% accuracy, to be mitochondrial. C06B8.4 C06B8.4 Member of the 7-transmembrane chemoreceptor family of G protein-coupled receptors (GPCR), has low similarity to C. elegans ODR-10, which is a G protein-coupled receptor involved in odorant response 7tm receptor C06B8.5 C06B8.5 Member of the transposase family, which are required for excising and inserting mobile genetic elements, has very strong similarity to uncharacterized C. elegans C31A11.2 transposase C06B8.6 C06B8.6 Member of the 7-transmembrane chemoreceptor family of G protein-coupled receptors (GPCR), has low similarity to uncharacterized C. elegans T22F3.5 C06B8.7 C06B8.7 Protein containing three scavenger receptor cysteine rich domain, which may mediate protein-protein interactions Human M130 antigen like protein C06B8.8 C06B8.8 Protein with high similarity to ribosomal protein L38 (S. cerevisiae Rpl38p), which is a structural ribosomal protein, member of the ribosomal L38e family, which are part of the large ribosomal subunit rpl-38 encodes a large ribosomal subunit L38 protein. C06C3.1 mel-11;C06C3.1 Myosin phosphatase regulatory subunit required for embryonic elongation ankyrin-like repeats C06C3.3 C06C3.3 Protein with weak similarity to C. elegans UNC-89 C06C3.4 C06C3.4 Putative ortholog of C. elegans C06C3.9 gene product C06C3.5 C06C3.5 Protein with moderate similarity to C. elegans C06C3.8 gene product C06C3.6 C06C3.6 Member of the 7-transmembrane chemoreceptor family of G protein-coupled receptors (GPCR), has moderate similarity to uncharacterized C. elegans C10G11.4 C06C3.7 C06C3.7 Protein of unknown function, has weak similarity to S. cerevisiae Ynl136p C06C3.8 C06C3.8 Putative ortholog of C. elegans B0454.9 gene product This gene encodes a protein predicted by Eisenberg and coworkers, with 68% accuracy, to be mitochondrial. C06C3.9 C06C3.9 Protein containing a DUF38 domain of unknown function and an F-box domain, which links a target protein to ubiquitin-conjugating enzyme, has a region of low similarity to a region of C. elegans FOG-2, which is needed for the sexual identity of germ cells C06C6.1 C06C6.1 Member of the 7-transmembrane chemoreceptor family of G protein-coupled receptors (GPCR), has high similarity to uncharacterized C. elegans T10C6.2 7TM receptor C06C6.2 C06C6.2 Member of the 7-transmembrane chemoreceptor family of G protein-coupled receptors (GPCR), has weak similarity to C. elegans ODR-10, which is a G protein-coupled receptor involved in odorant response 7TM receptor C06C6.3 C06C6.3 Member of the 7-transmembrane chemoreceptor family of G protein-coupled receptors (GPCR), has weak similarity to C. elegans ODR-10, which is a G protein-coupled receptor involved in odorant response 7TM receptor C06C6.4 nhr-63;C06C6.4 Member of the nuclear hormone receptor/Zinc finger protein family Zinc finger, C4 type (two domains) C06C6.5 nhr-50;C06C6.5 Member of the nuclear hormone receptor/Zinc finger protein family Zinc finger, C4 type (two domains) C06C6.6 C06C6.6 Protein containing a WSN domain of unknown function, has high similarity to uncharacterized C. elegans Y57G7A.6 C06C6.7 C06C6.7 Protein containing a WSN domain of unknown function, has high similarity to uncharacterized C. elegans C06C6.6 C06C6.8 C06C6.8 Protein of unknown function, has strong similarity to uncharacterized C. elegans C06C6.9 C06C6.9 C06C6.9 Protein of unknown function, has strong similarity to uncharacterized C. elegans C06C6.8 C06E1.1 C06E1.1 Small protein of unknown function, has similarity to S. cerevisiae Yip2p, has weak similarity to human polyposis locus protein, TB2 C06E1.10 C06E1.10 Member of the RNA helicase, DEAH-box protein family ATP-dependent RNA helicase; The C06E1.10 gene encodes a DEAH helicase orthologous to the Drosophila KURZ, the human KIAA1517, and the S. cerevisiae ECM16 proteins. C06E1.11 C06E1.11 Protein with strong similarity to C. elegans C13G5.2 gene product C06E1.2 C06E1.2 Protein of unknown function, has weak similarity to C. elegans C06E1.5 C06E1.3 C06E1.3 Protein of unknown function C06E1.4 glr-1;not-3;C06E1.4 Alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA)-type glutamate receptor (GluR); a putative ligand-gated ion channel in post-synaptic structures of the ventral nerve chord and the nerve ring Glutamate receptor subunit; glr-1 encodes an AMPA (non-NMDA)-type ionotropic glutamate receptor subunit; GLR-1 activity is required for mediating the behavioral response to light nose touch and the frequency with which animals change locomotory direction in response to sensory cues such as food; GLR-1 and GLR-2, a second AMPA-type ionotropic glutatmate receptor, can interact to form functional heteromeric channels; GLR-1 is expressed in motorneurons and interneurons, including four of the five pairs of command interneurons that are required for locomotory control; in the ventral nerve cord and nerve ring, GLR-1 localizes to perinuclear structures in cell bodies and to punctate structures that appear to be glutamatergic postsynaptic specializations; proper GLR-1 localization in the anterior ventral nerve cord of older larvae and adults requires activity of the class I PDZ protein LIN-10; GLR-1 is ubiquitinated in vivo and its abundance at postsynaptic elements, which may influence postsynaptic strength, is regulated by ubiquitination. C06E1.5 C06E1.5 Protein of unknown function, has weak similarity to C. elegans C06E1.2 C06E1.6 C06E1.6 Protein of unknown function, has weak similarity to C. elegans C06E1.2 C06E1.7 C06E1.7 Member of the glycosyl transferase family 11, which hydrolyze the glycosidic bond between two or more carbohydrates, has moderate similarity to uncharacterized C. elegans C14C6.3 C06E1.8 C06E1.8 Protein containing three C2H2 type zinc finger domains, which bind nucleic acids, has low similarity to C. elegans HAM-2, which is a putative transcription factor required for migration of hermaphrodite-specific neurons C06E1.9 C06E1.9 Protein of unknown function C06E2.1 C06E2.1 Protein of unknown function C06E2.2 C06E2.2 Protein of unknown function C06E2.3 C06E2.3 Protein with high similarity to huntingtin interacting protein 2 (human HIP2), which is a ubiquitin-conjugating enzyme that interacts with huntingtin (HD) in the brain, member of the ubiquitin-conjugating enzyme (E2) family ubiquitin-conjugating enzyme C06E2.5 C06E2.5 Protein of unknown function C06E2.7 C06E2.7 Protein containing a UBA (ubiquitin associated) or TS-N domain, has low similarity to uncharacterized C. elegans F40G9.3 ubc-22 encodes an E2 ubiquitin-conjugating enzyme orthologous to Saccharomyces cerevisiae UBC8 and human UBC1/HIP2 (Huntingtin interacting protein 2, OMIM:602846) which are involved in regulating fructose-1,6-bisphosphatase and huntingtin catabolism, respectively; by homology, UBC-22 is likely required for covalent attachment of ubiquitin to select target proteins to facilitate their degradation; however, as loss of UBC-22 activity via RNA-mediated interference (RNAi) does not result in any abnormalities, the precise role of UBC-22 in C. elegans development and/or behavior is not yet known. C06E4.1 C06E4.1 Protein with strong similarity to C. elegans C43E11.5 gene product C06E4.2 C06E4.2 Protein of unknown function C06E4.3 C06E4.3 Member of the short-chain dehydrogenase-reductase family, which are NAD- or NADP-dependent oxidoreductases, has low similarity to peroxisomal trans 2-enoyl CoA reductase (human HSA250303), which catalyzes the reduction of trans 2-enoyl CoAs dehydrogenase; This gene encodes a protein predicted by Eisenberg and coworkers, with 68% accuracy, to be mitochondrial. C06E4.4 C06E4.4 Protein of unknown function, has high similarity to uncharacterized C. elegans C06E4.3 dehydrogenase; This gene encodes a protein predicted by Eisenberg and coworkers, with 68% accuracy, to be mitochondrial. C06E4.5 C06E4.5 Protein with moderate similarity to C. elegans Y48B6A.10 gene product C06E4.6 C06E4.6 Member of the alcohol/ribitol dehydrogenase-like protein family dehydrogenase; This gene encodes a protein predicted by Eisenberg and coworkers, with 68% accuracy, to be mitochondrial. C06E4.7 C06E4.7 Protein of unknown function C06E4.8 C06E4.8 Protein of unknown function C06E7.1 C06E7.1 Protein with high similarity to C. elegans C49F5.1, contains two S-adenosylmethionine synthetase N-terminal domains, an S-adenosylmethionine synthetase central domain, and an S-adenosylmethionine synthetase C-terminal domain S-adenosylmethionine synthetase C06E7.2 C06E7.2 Protein of unknown function C06E7.3 C06E7.3 Protein with high similarity to C. elegans C49F5.1, contains an S-adenosylmethionine synthetase N-terminal domain, an S-adenosylmethionine synthetase C-terminal domain, and an S-adenosylmethionine synthetase central domain S-adenosylmethionine synthetase C06E7.4 C06E7.4 Putative ortholog of C. elegans C06E7.5 gene product C06E7.5 C06E7.5 Putative ortholog of C. elegans C06E7.4 gene product C06E7.6 spe-27;C06E7.6 Protein required for spermatogenesis Uncloned locus required for sperm activation (morphogenesis of sperm to crawling spermatozoa), and may act in a common signaling pathway with spe-12 and spe-29 to initiate sperm activation, based on genetic analysis. C06E7.7 C06E7.7 Protein of unknown function, has low similarity to uncharacterized C. elegans Y73B6BL.10 7TM chemoreceptor, srv family C06E8.1 C06E8.1 Protein of unknown function C06E8.3 prk-1;C06E8.3 Protein containing two protein kinase domains, has a region of moderate similarity to proviral integration site 3 (kinase induced by depolarization 1) (rat Pim3), which is a serine-threonine protein kinase that may play a role in neurogenesis Protein kinase C06E8.4 C06E8.4 Member of the reverse transcriptase protein family, which are RNA-dependent DNA polymerases, has very strong similarity to uncharacterized C. elegans F28E10.3 C06E8.5 C06E8.5 Protein containing a lipopolysaccharide-binding protein, bactericidal permeability-increasing protein or cholesteryl ester transfer protein C-terminal domain, has weak similarity to uncharacterized C. elegans C55C3.1 bacterial permeability-increasing protein C06G1.1 C06G1.1 Protein containing a lipopolysaccharide-binding protein, bactericidal permeability-increasing protein or cholesteryl ester transfer protein C-terminal domain C06G1.2 C06G1.2 Protein of unknown function, has weak similarity to C. elegans F35C5.3 C06G1.4 C06G1.4 Protein of unknown function, has low similarity to uncharacterized C. elegans B0041.2 C06G1.5 C06G1.5 Protein of unknown function, has a region of moderate similarity to protein phosphatase 2 (PP2A) regulatory subunit B (mouse Ppp2r3), which cooperates in dephosphorylation of retinoblastoma protein (Rb1)-related p107 leading to cell cycle arrest protein phosphatase PP2A C06G3.1 C06G3.1 Protein containing a nuclear hormone receptor ligand-binding domain, which bind DNA and may regulate transcription, and a nuclear hormone receptor C4-type zinc finger domain, has weak similarity to hepatocyte nuclear factor 4 alpha (human HNF4A) zinc finger protein C06G3.10 CeLDLC;C06G3.10 Protein with moderate similarity to H. sapiens LDLC, which is a protein required for normal Golgi function C06G3.11 C06G3.11 Protein containing a Tim10 or DDP family zinc finger domain, has moderate similarity to S. cerevisiae Tim9p, which is an essential component of the mitochondrial import machinery and required for transfer of hydrophobic inner membrane carrier proteins tin-9 encodes a member of the Tim10/DDP family of zinc finger proteins, a family of proteins typically involved in mitochondrial protein import, and localized to the mitochondrial intermembrane space. C06G3.12 C06G3.12 Protein with strong similarity to C. elegans F54H12.3 gene product C06G3.2 klp-18;C06G3.2 Protein containing a kinesin motor domain, which binds ATP and microtubules, has low similarity to kinesin heavy chain (human KIF5B), which is a microtubule-associated motor protein that may function in intracellular organelle transport kinesin-like protein C06G3.3 C06G3.3 Protein of unknown function C06G3.4 C06G3.4 Protein of unknown function, has high similarity to uncharacterized C. elegans F56D5.9 C06G3.5 C06G3.5 Member of the adenosine and AMP deaminase family, which catalyze hydrolytic deamination of adenosine, has moderate similarity to adenosine deaminase (mouse Ada), which has roles in immune response and various developmental processes adeonsine deaminase; C06G3.5 is orthologous to human ADENOSINE DEAMINASE (ADA; OMIM:102700), which when mutated leads to severe combined immunodeficiency. C06G3.6 C06G3.6 Protein with moderate similarity to C. elegans T12G3.1 gene product zinc finger protein C06G3.7 TR-Se;C06G3.7 Member of the reductase/oxidoreductase protein family, probable selenocysteine-containing thioredoxin reductase pyridine nucleotide-disulphide oxidoreductase; C06G3.7 encodes an homolog of the mammalian thioredoxin reductase isozymes TR1 and TR2; like its mammalian homologs, C06G3.7 has a TGA-encoded C-terminal penultimate selenocysteine (Sec) residue; labelling of C. elegans with selenium-75 demonstrates that TR-Se is the major naturally occurring selenoprotein in C. elegans, and computational analysis indicates that it is probably the only selenoprotein encoded by the genome; the 3'-untranslated region of this gene contains a selenocysteine insertion sequence that is functional in mammalian cell culture; by phylogenetic profiling, C06G3.7 protein is predicted to be mitochondrial. C06G3.8 C06G3.8 Protein containing an OB-fold nucleic acid binding domain, which are found in tRNA synthetases, helicases, and polymerases C06G3.9 C06G3.9 Protein of unknown function, has weak similarity to uncharacterized human KIAA0776 C06G4.2 C06G4.2 Member of the calpain family of cysteine proteases, contains two large subunit III calpain domains, has a region of high similarity to a region of the digestive tract member of the calpain calcium-dependent non-lysosomal proteases (mouse Ncl-4) Calpain; clp-1 encodes a calpain homolog that has significant identity to mammalian calpains over its whole length and that contains motifs typical of calpains, including a thiol (cysteine) protease active site and a Ca[2+]-binding domain; CLP-1 is required, in parallel with TRA-3 but in series with ASP-3 and ASP-3, for degenerative (necrotic-like) cell death in neurons induced by mutations such as mec-4(d), deg-3(d), or gsa-1(gf). C06G4.4 C06G4.4 Protein of unknown function C06G4.5 C06G4.5 Member of the rhodopsin family of G protein-coupled receptors (GPCR), has low similarity to neuropeptide FF receptor 2 (rat Npgpr), which is a G protein-coupled receptor that may play a role in pain modulation, opiate tolerance, and adult feeding behavior G-protein coupled receptor C06G8.1 C06G8.1 Member of the MtN3-saliva family, which contain a region of two transmembrane helices C06G8.2 pep-1;CPTA;C06G8.2;opt1 Member of the proton-coupled oligopeptide transporter (POT) family of membrane transporters oligopeptide transporter; opt-1 encodes a high-affinity, proton-coupled oligopeptide transporter; when expressed in Xenopus ooctyes, OPT-1 exhibits proton-coupled transport activity for a broad spectrum of peptide substrates; opt-1 mRNA is detected at all stages of development, but is expressed at highest levels in late larval and adult stages; additionally, an opt-1::GFP reporter exhibits expression primarily in vulval, pharyngeal, and anal muscles; as loss of opt-1 activity via large-scale RNAi screens does not result in any obvious abnormalities, the precise role of opt-1 in C. elegans development and/or behavior is not yet known. C06G8.3 C06G8.3 Member of the ZIP zinc transporter family, which may be metal transporters C06G8.4 C06G8.4 Protein of unknown function, has high similarity to uncharacterized C. elegans B0547.4 7TM chemoreceptor (srd-family) C06H2.1 C06H2.1 Protein with similarity to D. melanogaster mitochondrial ATP synthase D chain (ATPSYN-D) ATP synthase D chain C06H2.2 C06H2.2 Protein containing a START (Steroidogenic Acute Regulatory protein) domain, which is a lipid-binding domain in StAR, HD-ZIP and signaling proteins, has a region of low similarity to phosphatidylcholine transfer protein (human PCTP) phosphatidylcholine transfer protein C06H2.3 C06H2.3 Protein containing an acetyltransferase (GNAT) domain and a Jumonji (jmjC) domain, has a region of low similarity to a region of protein associated with small stress proteins 1 (rat Pass1), which inhibits rat Hsp27-mediated tolerance to heat shock Acetyltransferase (GNAT) family C06H2.4 C06H2.4 Member of the reduced folate carrier family, which transport reduced folate into cells, has low similarity to thiamine transporter protein 1 (human SLC19A2), which is associated with thiamine responsive megaloblastic anemia (TRMA) folate transporter protein; C06H2.4 is orthologous to the human gene THIAMINE TRANSPORTER 1 (SLC19A2; OMIM:603941), which when mutated leads to disease. C06H2.5 C06H2.5 Protein of unknown function, has weak similarity to C. elegans W01C9.5 Globin C06H2.6 C06H2.6 Protein of unknown function C06H5.1 C06H5.1 Protein containing an F-box domain, which serve as a link between a target protein and a ubiquitin-conjugating enzyme, and a DUF38 domain of unknown function, has weak similarity to C. elegans FOG-2, which is required for the sexual identity of germ cells This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins; this gene's encoded protein also contains an FTH/DUF38 motif, which may also mediate protein-protein interaction. C06H5.2 C06H5.2 Protein containing an F-box domain, which serve as a link between a target protein and a ubiquitin-conjugating enzyme, and a DUF38 domain of unknown function, has weak similarity to C. elegans FOG-2, which is required for the sexual identity of germ cells This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins; this gene's encoded protein also contains an FTH/DUF38 motif, which may also mediate protein-protein interaction. C06H5.6 C06H5.6 Member of the sugar (and other) transporter family, has weak similarity to the proton-organic cation transporter (mouse Slc22a4), which efficiently transports various organic cations and also exhibits low carnitine transport activity C06H5.7 C06H5.7 Protein of unknown function, has weak similarity to C. elegans Y57G11C.27 C07A12.1 ham-2;C07A12.1 Putative transcription factor required for migration of hermaphrodite-specific neurons; downstream target of HOX family member EGL-5 zinc finger protein; The ham-2 gene encodes a C2H2 zinc finger-containing protein required for proper migration of the hermaphrodite-specific neurons (HSNs) and proper attachment of the pharynx to the nose; HAM-2 is expressed in the nuclei of the HSNs during migration, and acts downstream of EGL-5, a posterior group Hox protein, in HSN specification; HAM-2 acts redundantly with UNC-86 to downregulate UNC-43 expression in the HSNs after migration is complete. C07A12.2 C07A12.2 Protein of unknown function C07A12.3 nhr-35;C07A12.3 Putative nuclear hormone receptor, contains two C4-type zinc finger DNA-binding domains and a ligand binding domain, has similarity to human hepatocyte nuclear factors zinc finger protein C07A12.4 pdi-2;C07A12.4 Protein disulfide isomerase, beta subunit of prolyl 4-hydroxylase protein disulfide isomerase; This gene encodes a protein predicted by Eisenberg and coworkers, with 52% accuracy, to be mitochondrial. C07A12.5 C07A12.5 Protein containing five C2H2 type zinc finger domains, which bind nucleic acids zinc finger protein C07A12.7 C07A12.7 Protein containing two VHS domains of unknown function and two GAT domains, has a region of low similarity to a region of signal transducing adaptor molecule 1 (human STAM), which is a putative adaptor protein involved in signal transduction C07A4.1 C07A4.1 Protein containing two RNA recognition motifs (RRM, RBD, or RNP), has moderate similarity to TIA1 cytotoxic granule associated RNA-binding protein-like 1 (human TIAL1), which is a transcriptional repressor that binds platelet factor (human PF4) promoter RNA binding protein C07A4.2 C07A4.2 Putative ortholog of C. elegans C07A4.3 gene product extracellular protein C07A4.3 C07A4.3 Member of the SCP-like extracellular protein family, has a region of low similarity to a region of S. cerevisiae Pry1p, which may have a role in mating efficiency extracellular protein C07A9.1 C07A9.1 Member of the C-type lectin family C-type lectin C07A9.10 C07A9.10 Protein containing a ubiquitin carboxyl-terminal hydrolases family 2 domain Ubiquitin carboxyl-terminal hydrolases family 2 C07A9.11 C07A9.11 Member of the sodium or calcium exchanger protein family of membrane transporters, which regulate intracellular Ca2+ concentrations, has weak similarity to potassium-dependent sodium-calcium exchanger 2 (rat Nckx2), which is a calcium:sodium antiporter Na/Ca, K antiporter C07A9.2 C07A9.2;3J784 Member of the G10 family, which are highly conserved but of unknown function, has moderate similarity to S. cerevisiae Bud31p, which regulates cell growth G10 protein C07A9.3 C07A9.3 Protein containing a protein kinase domain, has a region of high similarity to tousled-like kinase 2 (human TLK2), which is a serine-threonine kinase that exhibits DNA replication-dependent kinase activity that peaks during S-phase serine/threonine kinase; tlk-1 encodes, through alternative splicing, two isoforms of a Tousled-class serine/threonine protein kinase; TLK-1A/B are orthologous to Tousled from A. thaliana; tlk-1(RNAi) embryos have, compared to normal embryos, reduced phosphorylation of the RNA polymerase II C-terminal domain at Serine-2 and methylation of histone H3 at Lysine-36 (posttranslational modifications associated with transcriptional elongation), along with a lethal phenotype consistent with general defects in zygotic transcription; TLK-1A/B have a glutamine/asparagine-rich domain and a putative coil domain. C07A9.4 C07A9.4 Member of the sodium or calcium exchanger protein family of membrane transporters, which regulate intracellular Ca2+ concentrations, has weak similarity to a region of C. elegans F35C12.2, which is a potassium dependent Na/Ca exchanger Na/Ca,K antiporter C07A9.5 C07A9.5 Protein containing an EF hand domain, which are found in signaling, buffering or transport proteins, has weak similarity to a region of alpha actinin 2 (mouse Actn2), which may play a role in muscle cell fusion Actin-binding protein C07A9.6 C07A9.6;C07A9.6 Protein containing two UDP-glucoronosyl and UDP-glucosyl transferase domains and a ubiquitin carboxyl-terminal hydrolases family 2 domain, has a region of low similarity to a region of UDP glycosyltransferase 2 family polypeptide B (human UGT2B) UDP-glucuronosyltransferase C07A9.7 C07A9.7 Protein with weak similarity to S. cerevisiae YPL165C C07A9.8 C07A9.8 Member of the C. elegans putative membrane protein family 8, has low similarity to a region of bestrophin (human VMD2), which plays a role in vision and is associated with Bests disease, adult vitelliform macular dystrophy, and bull's eye maculopathy Putative membrane protein C07A9.9 C07A9.9 Protein of unknown function C07B5.2 C07B5.2 Protein of unknown function C07B5.3 C07B5.3 Protein with moderate similarity to C. elegans F17C11.2 gene product C07B5.4 C07B5.4 Protein containing a pleckstrin homology (PH) domain, which mediate protein-protein and protein-lipid interactions C07B5.5 nuc-1;C07B5.5 Endonuclease with strong similarity to H. sapiens DNase II, involved in DNA degradation during apoptosis The nuc-1 gene encodes a DNase II homolog similar to mammalian and Drosophila DNaseII enzymes and is required for DNA degradation during apoptosis as well as for degradation of dietary DNA during normal feeding; during apoptosis, NUC-1 functions in apoptotic cells at an intermediate stage of DNA degradation, after the killing step, but prior to cell-corpse engulfment. C07B5.6 C07B5.6 Protein of unknown function C07C7.1 C07C7.1 Protein of unknown function C07D10.1 C07D10.1 Protein containing an F-box domain, which serve as a link between a target protein and a ubiquitin-conjugating enzyme C07D10.2 C07D10.2 Protein containing two BTB (BR-C, ttk and babor) or POZ (Pox virus and zinc finger) domains, which are found in some DNA and actin binding proteins and may mediate protein-protein interactions, has low similarity to C. elegans MEL-26 The C07D10.2 gene encodes a protein with a meprin-associated Traf homology (MATH) domain that may be involved in apoptosis. C07D10.3 C07D10.3 Member of the C. elegans Sre G protein-coupled chemoreceptor family, which are putative chemosensory receptors 7TM chemoreceptor, sre family C07D10.4 C07D10.4 Member of the astacin (M12A) family of metalloproteases, has a region of low similarity to a region of the meprin A alpha subunit (PABA peptide hydrolase, human MEP1A), which is found at increased levels in some colon carcinomas Zinc metalloprotease C07D10.5 C07D10.5 Protein of unknown function, has weak similarity to C. elegans F43E2.1 C07D8.2 C07D8.2 Putative ortholog of C. elegans K09E3.1 gene product C07D8.3 C07D8.3 Protein with strong similarity to C. elegans K09E3.1 gene product C07D8.4 C07D8.4 Protein of unknown function C07D8.5 C07D8.5 Member of the aldo-keto reductase family, which include some related monomeric NADPH-dependent oxidoreductases, has a region of high similarity to a region of aldose reductase (rat Akr1b1), which acts in the polyol pathway and in xenobiotic metabolism C07D8.6 C07D8.6 Member of the aldo-keto reductase family, which include some related monomeric NADPH-dependent oxidoreductases, has moderate similarity to aldose reductase (aldehyde dehydrogenase, human AKR1B1), which catalyzes the reduction of glucose to sorbitol aldehyde reductase C07E3.1 C07E3.1 Protein containing a G-patch domain, which are found in RNA processing proteins, has low similarity to uncharacterized human TIP39 C07E3.10 C07E3.10 Protein of unknown function C07E3.2 C07E3.2 Protein with low similarity to S. cerevisiae Noc2p, which is involved in biogenesis of the 60S ribosome C07E3.3 C07E3.3 Protein with weak similarity to human and S. cerevisiae mucins (cell surface flocculins) C07E3.4 C07E3.4 Member of the protein-tyrosine phosphatase family, which are involved in cell growth control, proliferation, differentiation and transformation, has strong similarity to uncharacterized C. elegans F57H12.5 Protein-tyrosine phosphatase C07E3.5 C07E3.5 Protein of unknown function C07E3.6 C07E3.6 Protein of unknown function C07E3.7 C07E3.7 Protein containing a homeobox domain (homeodomain), which are found in transcription factors C07E3.8 C07E3.8 Protein of unknown function, has low similarity to a region of C. elegans PHA-1, which is involved in pharyngeal development C07E3.9 C07E3.9 Member of the phospholipase A2 family, has moderate similarity to group IB phospholipase A2 (human PLA2G1B), which is a pancreatic secreted phospholipase A2 that hydrolyzes the phospholipid sn-2 ester bond and has a role in signal transduction phospholipase A2 C07F11.1 tol-1;C07F11.1 Putative ortholog of D. melanogaster Tollo (Tollo), required for embryonic development The tol-1 gene encodes a predicted transmembrane protein that is the sole C. elegans Toll-like receptor (TLR); TOL-1 is required for proper embryonic development and for pathogen avoidance behavior, and is expressed primarily in the nervous system. C07F11.2 C07F11.2 Protein of unknown function, has strong similarity to C. elegans C07F11.E C07G1.1 C07G1.1 Member of the trypsin family of serine proteases, has moderate similarity to proprostasin (human PRSS8), which is a seminal fluid serine-type endopeptidase that may act as a suppressor of invasive prostate cancer and is upregulated in ovarian cancer peptidase; try-2 encodes a homolog of human TRYP1 and ELA2; mutation of human TRYP1 or ELA2 leads, respectively, to hereditary pancreatitis (OMIM:276000) or cyclic haematopoiesis (OMIM:162800). C07G1.2 C07G1.2 Protein containing a kringle domain, two low-density lipoprotein (LDL) receptor class A domains, a PAN domain, and a C-type lectin domain LDL-receptor domain protein C07G1.3 pct-1;C07G1.3 Protein containing two protein kinase domains, has a region of high similarity to PCTAIRE protein kinase 1 (human PCTK1), which is a cell-cycle regulated serine-threonine protein kinase that may be associated with X chromosome-linked heritable disorders ser/thr protein kinase C07G1.5 C07G1.5 Protein containing a FYVE zinc finger domain, a ubiquitin interaction motif, and a VHS domain of unknown function, has moderate similarity to hepatocyte growth factor regulated tyrosine kinase substrate (human HGS) The protein product of this gene is predicted to contain a glutamine/asparagine (Q/N)-rich ('prion') domain, by the algorithm of Michelitsch and Weissman (as of the WS77 release of WormBase, i.e., in wormpep77). C07G1.6 C07G1.6 Protein of unknown function C07G1.7 C07G1.7 Protein with moderate similarity to C. elegans M199.2 gene product C07G2.1 cej-1;C07G2.1 Protein containing three chitin binding peritrophin-A domains, which contain six conserved cysteines that probably form three disulfide bridges Endochitinase (partial); cej-1 encodes a protein with a chitin binding peritrophin-A domain that is required, in conjunction with B0280.5, for early embryonic development; cej-1 mRNA is expressed specifically in the adult hermaphrodite germ line, is a direct target of GLD-1, and has an RNAi phenotype consistent with the hypothesis that CEJ-1 is an effector of GLD-1 in the germline. C07G2.2 C07G2.2 Protein containing a bZIP (basic-leucine zipper) transcription factor domain bZIP transcription factor C07G2.3 cct-5;C07G2.3 Component of the cytosolic chaperonin containing T-complex polypeptide-1 TCP-1 like chaperonin; A homolog of the mouse chaperonin Ccte that affects protein folding; it is expressed at all life stages. C07G3.10 C07G3.10 Protein of unknown function C07G3.2 C07G3.2 Protein of unknown function, has high similarity to C. elegans T24A6.7 C07G3.3 C07G3.3 Member of the 7-transmembrane chemoreceptor family of G protein-coupled receptors (GPCR), has low similarity to C. elegans ODR-10, which is a G protein-coupled receptor involved in odorant response 7TM chemoreceptor, str family C07G3.4 C07G3.4 Member of the 7-transmembrane chemoreceptor family of G protein-coupled receptors (GPCR), has low similarity to C. elegans ODR-10, which is a G protein-coupled receptor involved in odorant response 7TM chemoreceptor, str family C07G3.5 C07G3.5 Member of the 7-transmembrane chemoreceptor family of G protein-coupled receptors (GPCR), has low similarity to C. elegans ODR-10, which is a G protein-coupled receptor involved in odorant response 7TM chemoreceptor, str family C07G3.6 C07G3.6 Member of the 7-transmembrane chemoreceptor family of G protein-coupled receptors (GPCR), has low similarity to C. elegans ODR-10, which is a G protein-coupled receptor involved in odorant response 7TM chemoreceptor, str family C07G3.7 C07G3.7 Protein containing a DUF40 domain of unknown function, which contain four conserved cysteines, has high similarity to uncharacterized C. elegans Y113G7B.9 C07G3.8 C07G3.8 Protein with strong similarity to C. elegans K03B4.6 gene product C07G3.9 C07G3.9 Protein containing a UDP-glucoronosyl and UDP-glucosyl transferase domain, has weak similarity to UDP glycosyltransferase 1 family polypeptide A1 (human UGT1A), which acts in bilirubin conjugation and plays a role in Gilbert and Crigler-Najjar syndromes C07H4.1 C07H4.1 Protein of unknown function C07H4.2 clc-5;clh-5;C07H4.2 Chloride channel protein chloride channel protein; The clh-5 gene encodes a chloride channel, whose human homologs include CLC1 and CLCN5; the latter homolog is imvolved in receptor-mediated endocytosis. C07H6.1 C07H6.1 Protein containing one BRCA1 (breast cancer type 1) C terminus (BRCT) and one ATP-dependent DNA ligase domain, has weak similarity to ATP-dependent DNA ligase IV (human LIG4), which is a DNA repair enzyme that is associated with radiosensitive leukemia C07H6.2 C07H6.2 Small protein of unknown function, has moderate similarity to uncharacterized C. elegans K10H10.7 C07H6.3 C07H6.3 Protein with weak similarity to cytoplasmic linker protein (CLIP) associating protein 2 (human CLASP2), which is a microtubule-binding protein that is also likely to bind CLIP family members and may play a role in microtubule stabilization C07H6.4 C07H6.4 Protein containing an RNA recognition motif (RRM, RBD, or RNP) and a Surp module (SWAP domain), which may bind RNA, has low similarity to uncharacterized human KIAA0332 Probable RNA binding protein C07H6.5 cgh-1;C07H6.5 Probable DEAD-box type RNA helicase; required for gametogenesis and prevention of germline apoptosis ATP-dependent RNA helicase; The ortholog of a RNA helicase ste13/ME31B/RCK/p54 that is required for oocyte and sperm function and the prevention of physiological germline-associated apoptosis; it is expressed in the early embryo and germline and localizes to P granules. C07H6.6 rad-5;clk-2;C07H6.6 DNA damage checkpoint protein; similar to yeast telomere binding protein Tel2p; involved in regulation of biological clock functions The clk-2 gene encodes an ortholog of the telomere length-regulating protein Tel2p from S. cerevisiae; clk-2 mutations extend lifespan, indicating that CLK-2 positively mediates some aspect of normal aging. C07H6.7 lin-39;ceh-15;C07H6.7 Homeodomain transcription factor involved in cell fate determination in a variety of cell lineages within the central body region C. elegans homeobox gene lin-39 C07H6.8 cux-7;C07H6.8 Protein of unknown function, has moderate similarity to 721P protein (human DXYS155E) cux-7 encodes an conserved but unfamiliar protein orthologous to the human gene XE7 and the Drosophila gene CG2179-PA; since cux-7 is in an operon with clk-2, CUX-7 might have some role in telomere maintenance, development or rhythmic behavior; however, cux-7 currently has no known function, and is dispensable for viability and gross morphology in mass RNAi screens. C07H6.9 C07H6.9 Protein of unknown function C08A9.1 sod-3;MnSOD;C08A9.1 Manganese superoxide dismutase superoxide dismutase; sod-3 encodes a iron/manganese superoxide dismutase, predicted to be mitochondrial, that might defend against oxidative stress and promote normal lifespan; sod-3 mRNA levels are diminished by mutation of daf-16, and heterologously expressed SOD-3 in E. coli protects against methyl viologen-induced oxidative stress. C08A9.3 C08A9.3 Protein of unknown function, has high similarity to uncharacterized C. elegans C30E1.2 C08A9.4 C08A9.4 Protein of unknown function, has high similarity to uncharacterized C. elegans C30E1.3 C08A9.5 C08A9.5 Protein of unknown function, has moderate similarity to uncharacterized C. elegans C30E1.4 C08A9.6 C08A9.6 Protein of unknown function, has high similarity to uncharacterized C. elegans C08A9.8 C08A9.7 C08A9.7 Protein of unknown function, has moderate similarity to uncharacterized C. elegans C41H7.4 C08A9.8 C08A9.8 Protein of unknown function, has high similarity to uncharacterized C. elegans C08A9.6 C08A9.9 C08A9.9 Protein of unknown function, has high similarity to uncharacterized C. elegans K09E3.5 C08B11.1 zyg-11;C08B11.1 Protein required for zygote formation Leucine Rich Repeat (2 copies) C08B11.2 hda-2;C08B11.2 Protein with high similarity to histone deacetylase 1 (human HDAC1), which is a deacetylase and transcriptional corepressor that controls cell proliferation, member of the histone deacetylase family, which catalyze removal of acetyl groups from histones transcriptional regulatory protein (RPD3) C08B11.3 C08B11.3 Member of the ARID DNA binding domain protein family Zinc finger, C2H2 type C08B11.4 nrf-6;C08B11.4 Protein predicted to span a membrane twelve times, member of a family of C. elegans and D. melanogaster proteins C08B11.5 sap-49;SAP49;C08B11.5 Putative U2 snRNP-associated protein, putative ortholog of human spliceosome associated protein SAP49 and yeast Hsh49p Poly(A) RNA binding protein C08B11.6 C08B11.6 Member of the actin family, which are major cytoskeletal proteins, has low similarity to actin (C. albicans Act1p), which is involved in cell polarization, endocytosis, and other cytoskeletal functions actin C08B11.7 C08B11.7 Putative ubiquitin carboxyl-terminal hydrolase, has strong similarity to human ubiquitin carboxyl-terminal hydrolase BAP1 thiolesterase C08B11.8 C08B11.8 Protein with moderate similarity to dolichyl-P-Glc:Man9GlcNAc2-PP-dolichylglucosyltransferase (human ALG6), which functions in dolichyl pyrophosphate-linked Glc3Man9GlcNAc2 synthesis C08B11.9 C08B11.9 Protein of unknown function C08B6.1 C08B6.1 Protein containing a UDP-glucoronosyl and UDP-glucosyl transferase domain, has weak similarity to UDP glycosyltransferase 2 family polypeptide B7 (human UGT2B7), which glucuronidates androgens, retinoids, lipids and specific drugs UDP-glucuronosyl transferase C08B6.10 C08B6.10 Protein of unknown function proline rich proteoglycan C08B6.2 C08B6.2 Protein with strong similarity to C. elegans C44H9.6 gene product C08B6.3 C08B6.3 Protein containing a DUF138 domain of unknown function, has high similarity to uncharacterized C. elegans F46F5.7 C08B6.4 C08B6.4 Member of the plant chitinase class I family, which hydrolyze the beta-1,4-N-acetyl-D-glucosamine bonds in chitin polymers destroying chitin-containing cell walls of pathogens, has strong similarity to uncharacterized C. elegans R10D12.15 chitinase C08B6.5 C08B6.5 Protein containing a ligand-gated ion channel domain, which are found in ionotropic glutamate receptors and NMDA receptors glutamate receptor transmembranous domain C08B6.6 C08B6.6 Protein of unknown function C08B6.7 C08B6.7 Protein containing five WD domains (WD-40 repeat), which may mediate protein-protein interactions, has moderate similarity to dystrophia myotonica-containing WD repeat (mouse Dm9), which is a putative signaling protein associated with myotonic dystrophy 59 protein C08B6.8 C08B6.8 Protein with high similarity to human DKFZP566E144, which is a 3'-5' exonuclease, member of the exonuclease family YJER protein C08B6.9 C08B6.9 Member of the UBA-THIF-type NAD-FAD binding fold family, has low similarity to SUMO-1 activating enzyme 1 subunit (sentrin-activating enzyme complex, human SAE1), which catalyzes the transfer of SUMO-1 (UBL1), SUMO2 and SUMO3 ubiquitin activating enzyme; aos-1 encodes the C. elegans ortholog of Saccharomyces cerevisiae Aos1p and human SUMO-1 activating enzyme E1 N subunit; by homology, AOS-1 is predicted to form, with a catalytic subunit, UBA-2, a heterodimeric enzyme that activates the ubiquitin-like protein SMO-1/SUMO in preparation for its covalent attachment to target proteins to regulate their subcellular localization and/or stability; in C. elegans, AOS-1 is required for embryonic and larval development, as well as for proper Hox gene regulation; uba-2/aos-1(RNAi) animals that survive embryogenesis show ectopic expression of EGL-5 and ectopic anterior sensory ray formation. | aos-1 encodes the C. elegans ortholog of Saccharomyces cerevisiae Aos1p and human SUMO-1 activating enzyme E1 N subunit; by homology, AOS-1 is predicted to play a role in protein targeting and/or stabilization and to form, with UBA-2, a heterodimeric enzyme that activates the ubiquitin-like protein SUMO in preparation for its covalent attachment to target proteins; loss of aos-1 activity via large-scale RNAi screens indicates that AOS-1 is required for embryonic and larval development. C08C3.1 egl-5;ceh-11;C08C3.1 Homeodomain transcription factor required for posterior patterning; similar over the homeodomain to many human and D. melanogaster homeodomain transcription factors egl-5 encodes a homeodomain transcription factor, orthologous to Drosophila Abd-B and the vertebrate Hox9-13 proteins, that is required for specification of the HSN cell fate and of cell fates within the tail region; EGL-5 is expressed in the posterior of the animal. C08C3.2 C08C3.2 Protein containing a BTB (BR-C, ttk and babor) or POZ (Pox virus and zinc finger) domain, which may mediate protein-protein interactions, and a meprin and TRAF homology (MATH) domain, has high similarity to uncharacterized C. elegans F40B1.1 C08C3.3 mab-5;C08C3.3 Homeodomain transcription factor involved in postembryonic development; has similarity over the homeodomain to many human and D. melanogaster homeodomain transcription factors C08C3.4 C08C3.4 Protein of unknown function, has weak similarity to C. elegans R10E4.1 C08D8.1 C08D8.1 Protein of unknown function, has low similarity to uncharacterized C. elegans F36G9.3 C08D8.2 C08D8.2 Protein of unknown function, has a region of low similarity to a region of tropomodulin (human TMOD), which is a putative capping protein of the actin thin filament pointed end and cytoskeletal lattice integral component that regulates cell adhesion C08E3.1 C08E3.1 Protein of unknown function, has very strong similarity to uncharacterized C. elegans C08E3.13 C08E3.10 C08E3.10 Protein containing an F-box domain, which serve as a link between a target protein and a ubiquitin-conjugating enzyme, and a DUF38 domain of unknown function, has low similarity to C. elegans T07D3.1, which may function in germ-line cell differentiation This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins; this gene's encoded protein also contains an FTH/DUF38 motif, which may also mediate protein-protein interaction. C08E3.11 C08E3.11 Protein with strong similarity to C. elegans C08E3.8 gene product C08E3.12 C08E3.12 Protein containing a DUF38 domain of unknown function, has a region of low similarity to a region of C. elegans T07D3.1, which functions in gametogenesis and positive regulation of body size C08E3.13 C08E3.13 Protein of unknown function, has very strong similarity to uncharacterized C. elegans C08E3.1 C08E3.2 C08E3.2 Protein containing a BTB (BR-C, ttk and babor) or POZ (Pox virus and zinc finger) domain, which are found in some DNA and actin binding proteins and may mediate protein-protein interactions, has moderate similarity to uncharacterized C. elegans B0047.2 C08E3.3 C08E3.3 Protein containing a BTB (BR-C, ttk and babor) or POZ (Pox virus and zinc finger) domain, which may mediate protein-protein interactions, and a meprin and TRAF homology (MATH) domain, has moderate similarity to uncharacterized C. elegans F45C12.11 C08E3.4 C08E3.4 Protein containing a DUF38 domain of unknown function, has low similarity to a region of C. elegans T07D3.1, which functions in gametogenesis and positive regulation of body size C08E3.5 C08E3.5 Protein containing an F-box domain, which serve as a link between a target protein and a ubiquitin-conjugating enzyme, and a DUF38 domain of unknown function, has low similarity to C. elegans T07D3.1, which may serve in germ-line stem cell differentiation This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins; this gene's encoded protein also contains an FTH/DUF38 motif, which may also mediate protein-protein interaction. C08E3.6 C08E3.6 Protein containing an F-box domain, which serve as a link between a target protein and a ubiquitin-conjugating enzyme, and a DUF38 domain of unknown function, has low similarity to C. elegans T07D3.1, which may serve in germ-line stem cell differentiation This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins; this gene's encoded protein also contains an FTH/DUF38 motif, which may also mediate protein-protein interaction. C08E3.7 C08E3.7 Protein containing an F-box domain, which serve as a link between a target protein and a ubiquitin-conjugating enzyme, and a DUF38 domain of unknown function, has low similarity to C. elegans T07D3.1, which may serve in germ-line stem cell differentiation This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins; this gene's encoded protein also contains an FTH/DUF38 motif, which may also mediate protein-protein interaction. C08E3.8 C08E3.8 Protein containing an F-box domain, which serve as a link between a target protein and a ubiquitin-conjugating enzyme, and a DUF38 domain of unknown function, has low similarity to C. elegans T07D3.1, which may function in germ-line cell differentiation This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins; this gene's encoded protein also contains an FTH/DUF38 motif, which may also mediate protein-protein interaction. C08E3.9 C08E3.9 Protein containing a DUF38 domain of unknown function, has low similarity to C. elegans T07D3.1, which functions gametogenesis and positive regulation of body size C08E8.1 C08E8.1 Protein with strong similarity to C. elegans Y41C4A.11 gene product C08E8.2 C08E8.2 Protein with strong similarity to C. elegans F57C2.5 gene product C08E8.3 C08E8.3 Protein with moderate similarity to C. elegans Y51B11_80.A gene product C08E8.4 C08E8.4 Protein with moderate similarity to C. elegans C07G3.2 gene product C08F1.1 C08F1.1 Protein containing four meprin and TRAF homology (MATH) domains, has low similarity to uncharacterized C. elegans C08F1.4 C08F1.3 C08F1.3 Protein containing an F-box domain, which serve as a link between a target protein and a ubiquitin-conjugating enzyme, has high similarity to uncharacterized C. elegans T08E11.6 This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins; its encoded protein also contains a Pfam-B45 motif of presently unknown function. C08F1.4 C08F1.4 Protein containing five meprin and TRAF homology (MATH) domains, has moderate similarity to uncharacterized C. elegans T16A1.1 The C08F1.4 gene encodes a protein closely similar to F36H5.2, which has a meprin-associated Traf homology (MATH) domain and may be involved in apoptosis. C08F1.5 C08F1.5 Protein containing seven meprin and TRAF homology (MATH) domains C08F1.6 C08F1.6 Protein of unknown function, has high similarity to uncharacterized C. elegans F36H5.4 C08F1.8 C08F1.8 Putative ortholog of C. elegans C08F1.5 gene product reverse transcriptase C08F1.9 C08F1.9 Member of the reverse transcriptase protein family, which are RNA-dependent DNA polymerases, has very strong similarity to uncharacterized C. elegans F28E10.3 C08F11.1 C08F11.1 Protein of unknown function, has high similarity to uncharacterized C. elegans F07C6.3 C08F11.10 C08F11.10 Protein of unknown function, has high similarity to uncharacterized C. elegans W03B1.3 C08F11.11 C08F11.11 Protein of unknown function, has moderate similarity to uncharacterized C. elegans Y45F10C.2 C08F11.12 C08F11.12 Protein of unknown function, has very strong similarity to uncharacterized C. elegans Y45F10C.2 C08F11.13 C08F11.13 Protein with moderate similarity to C. elegans F56G4.1 gene product C08F11.14 C08F11.14 Putative ortholog of S. cerevisiae MLS1 gene product (Malate synthase 1, functions in glyoxylate cycle, has near identity to Dal7p) C08F11.2 C08F11.2 Protein of unknown function, has low similarity to uncharacterized C. elegans ZK697.1 C08F11.3 C08F11.3 Protein with strong similarity to C. elegans F56G4.1 gene product C08F11.4 C08F11.4 Protein containing a DUF215 domain of unknown function, has high similarity to uncharacterized C. elegans F36G9.6 C08F11.5 C08F11.5 Protein containing a DUF38 domain of unknown function, and an F-box domain, which serve as a link between a target protein and a ubiquitin-conjugating enzyme, has low similarity to C. elegans FOG-2, which required for the sexual identity of germ cells This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins; this gene's encoded protein also contains an FTH/DUF38 motif, which may also mediate protein-protein interaction. C08F11.7 C08F11.7 Protein with weak similarity to C. elegans csp-1 gene product C08F11.8 C08F11.8 Protein containing a UDP-glucoronosyl and UDP-glucosyl transferase domain, has low similarity to UDP glycosyltransferase 1 A3 (human UGT1A3), which converts hydrophobic xenobiotic and endobiotic compounds to hydrophilic compounds for removal from cells UDP-glucoronosyl and UDP-glucosyl transferases C08F11.9 C08F11.9 Protein containing a DUF216 domain of unknown function, has moderate similarity to uncharacterized C. elegans H12I19.2 C08F8.1 C08F8.1 Protein with weak similarity to the human chaperone protein PFDN1 (prefoldin), a protein that delivers unfolded proteins to cytosolic chaperonin C08F8.2 C08F8.2 Protein containing a helicase conserved C-terminal domain, has low similarity to S. cerevisiae Suv3p, which is a mitochondrial RNA helicase and component of mitochondrial NTP-dependent 3'-5' exonuclease responsible for degradation of group I intron RNA ATP-dependent RNA helicase C08F8.3 C08F8.3 Protein of unknown function C08F8.4 C08F8.4 Member of the membrane bound O-acyl transferase (MBOAT) family, which are found in acyltransferase enzymes, has high similarity to uncharacterized C. elegans ZK550.1 C08F8.5 C08F8.5 Protein containing two F-box domains, which serve as a link between a target protein and a ubiquitin-conjugating enzyme This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins; its encoded protein also contains a Pfam-B45 motif of presently unknown function. C08F8.6 C08F8.6 Protein containing a protein kinase domain, has low similarity to casein kinase 1 epsilon (mouse Csnk1e), which is a serine-threonine protein kinase with broad substrate specificity that may function in DNA repair and regulation of circadian rhythm serine/threonine kinase C08F8.7 rrp-1;C08F8.7 Protein with high similarity to Ras related protein 1b (human RAP1B), which is involved in cell cycle progression, cellular proliferation, and possibly cAMP-responsive tumorigenesis, member of the Ras superfamily of GTP binding proteins RAS-related protein C08F8.8 nhr-67;C08F8.8 Putative nuclear hormone receptor, contains two C4-type zinc finger domains, has strong similarity to D. melanogaster and human TAILLESS proteins nuclear hormone receptor C08G5.1 C08G5.1 Protein containing a WSN domain of unknown function, has moderate similarity to uncharacterized C. elegans R06B10.2 C08G5.2 C08G5.2 Protein of unknown function, has low similarity to uncharacterized C. elegans M02B7.1 C08G5.3 C08G5.3 Protein of unknown function, has low similarity to uncharacterized C. elegans Y9C9A.1 C08G5.4 C08G5.4 Protein containing a C2 domain, which may be involved in calcium-dependent phospholipid binding, has low similarity to a region of synaptotagmin 7 (mouse Syt7), which is involved in synaptic vesicle fusion C08G5.5 C08G5.5 Protein of unknown function C08G5.6 C08G5.6 Protein of unknown function C08G9.2 C08G9.2 Member of the antistasin family, contains nine WAP-type (Whey Acidic Protein) four-disulfide core domains, six thyroglobulin type-1 repeats, and a kunitz or bovine pancreatic trypsin inhibitor domain, has a region of low similarity to mouse Slpi C08H9.1 C08H9.1 Member of the serine carboxypeptidase family, has low similarity to protective protein for beta-galactosidase (cathepsin A, human PPGB), which has serine carboxypeptidase activity and may be associated with galactosialidosis upon gene mutation serine carboxypeptidase C08H9.10 C08H9.10 Member of the glycosyl hydrolase 18 family, has a region of weak similarity to a region of chitinase 1 (chitotriosidase, human CHIT1), which is a chitinase that is implicated in chitotriosidase deficiency upon mutation chitinase C08H9.11 C08H9.11 Member of the glycosyl hydrolase 18 family, has a region of weak similarity to a region of chitinase 1 (chitotriosidase) (human CHIT1), which catalyzes the hydrolysis of chitin and is elevated in patients with Gaucher disease chitinase C08H9.12 C08H9.12 Member of the glycosyl hydrolase 18 family, has a region of weak similarity to chitinase 3-like 3 (mouse Chi3l3), which is a lectin with chitinase activity that plays a role in response to infection with chitin-bearing microorganisms chitinase C08H9.13 C08H9.13 Member of the glycosyl hydrolase 18 family, has low similarity to chitinase 1 (chitotriosidase) (human CHIT1), which is elevated in patients with Gaucher disease and is associated with chitotriosidase deficiency chitinase C08H9.14 C08H9.14 Member of the glycosyl hydrolase 18 family, has weak similarity to chitinase 3-like 1 (cartilage glycoprotein-39) (human CHI3L1), which binds chitin but does not have chitinase activity and is expressed in rheumatoid arthritis cartilage and synovial cells chitinase C08H9.2 C08H9.2 Protein containing 14 KH domains, which may bind RNA, has moderate similarity to high density lipoprotein binding protein (human HDLBP), which binds high density lipoproteins, mRNA and tRNA, and is involved in mRNA stability high-density lipoprotein-binding protein C08H9.3 C08H9.3 Protein of unknown function, has a region of moderate similarity to a region of S. cerevisiae Alg8p, which is a glucosyltransferase of the endoplasmic reticulum that has a role in adding glucose to the dolichol-linked oligosaccharide precursors glucosyltransferase C08H9.4 C08H9.4 Member of the glycosyl hydrolase 18 family, has a region of weak similarity to chitinase 3-like 3 (mouse Chi3l3), which is a lectin with chitinase activity and a chemotactic for eosinophils, bone marrow polymorphonuclear leukocytes, and T lymphocytes chitinase C08H9.5 old-1;tkr-1;C08H9.5 Putative receptor tyrosine protein kinase; similar to human and D. melanogaster fibroblast growth factor receptor-related protein kinases; overproduction extends lifespan tyrosine-protein kinase (KIN15/KIN16 subfamily) C08H9.6 C08H9.6 Member of the glycosyl hydrolase 18 family, has weak similarity to chitinase 3-like 1 (cartilage glycoprotein-39, human CHI3L1), which binds chitin but does not have chitinase activity and is expressed in rheumatoid arthritis cartilage and synovial cells chitinase C08H9.7 C08H9.7 Member of the glycosyl hydrolase 18 family, has a region of weak similarity to a region of chitinase 1 (chitotriosidase, human CHIT1), which catalyzes the hydrolysis of chitin and is elevated in patients with Gaucher disease chitinase C08H9.8 C08H9.8 Protein containing two protein kinase domains, has low similarity to C. elegans KIN-15, which is a receptor tyrosine protein kinase tyrosine-protein kinase (2 domains) C09B7.1 C09B7.1 Member of the rhodopsin family of G protein-coupled receptors (GPCR), has low similarity to 5-hydroxytryptamine (serotonin) receptor 7 (rat Htr7), which is a G protein-coupled receptor that stimulates adenylyl cyclase G-protein coupled receptor C09B7.2 C09B7.2 Protein with strong similarity to C. elegans C09H10.5 gene product transposase C09B8.1 ipp-5;C09B8.1 Protein containing an inositol polyphosphate phosphatase catalytic domain, has low similarity to inositol polyphosphate-5-phosphatase 40kD (5 phosphatase II, human INPP5A), which hydrolyzes inositol phosphates and is involved in signal transduction ipp-5 encodes a type I inositol 5-phosphatase homolog; ipp-5 acts downstream of let-23 to negatively regulate IP3 signaling and is involved in spermathecal contractions during ovulation; an ipp-5::gfp transcriptional reporter is expressed in the adult distal spermatheca and weakly in the proximal sheath. C09B8.3 C09B8.3 Protein of unknown function, has weak similarity to C. elegans F01D5.6 C09B8.4 C09B8.4 Protein of unknown function, has moderate similarity to uncharacterized C. elegans T10B11.6 C09B8.5 C09B8.5 Protein of unknown function C09B8.6 C09B8.6;hsp25 A chaperonin and member of the HSP20 family of heat shock proteins Small heat shock protein C09B8.7 pak-1;C09B8.7;CePAK Serine/threonine protein kinase with strong similarity to human and D. melanogaster p21-activated protein kinases, may interact with CeRac-1 and CDC-42 to mediate hypodermal cell shape changes during embryonic elongation Serine/threonine protein kinase; pak-1 is orthologous to the human gene P21-ACTIVATED KINASE 3 (PAK3; OMIM:300142), which when mutated leads to nonsyndromic mental retardation. C09B8.8 C09B8.8 Protein of unknown function C09B9.1 C09B9.1 Protein of unknown function, has weak similarity to C. elegans C15C8.1 C09B9.2 C09B9.2 Protein of unknown function, has low similarity to uncharacterized C. elegans F58D5.8 C09B9.3 C09B9.3 Member of the C. elegans putative membrane protein family 8, has a region of low similarity to a region of bestrophin (human VMD2), which plays a role in vision and causes Bests disease, adult vitelliform macular dystrophy, and bull's eye maculopathy C09B9.4 C09B9.4 Protein with low similarity to casein kinase 1 alpha 1 (human CSNK1A1), which is a serine/threonine protein kinase that may play a role in Alzheimer's disease ser/thr protein kinase C09B9.5 C09B9.5 Protein of unknown function C09B9.6 msp-55;C09B9.6 Member of the major sperm-specific protein (MSP) family major sperm protein; msp-55 encodes a member of the major sperm protein family. C09B9.7 C09B9.7 Protein of unknown function, has moderate similarity to uncharacterized C. elegans C01G5.4 C09C7.1 zig-4;C09C7.1 Putative member of Immunoglobulin superfamily IG-like C2-type domains C09D1.1 unc-89;phm-1;C09D1.1 Muscle cell protein required for coordinated locomotion, member of the immunoglobulin protein family immunoglobin-like protein C09D1.2 C09D1.2 Protein containing a C-type lectin domain, which mediate calcium-dependent carbohydrate recognition C09D4.1 C09D4.1 Member of the sugar (and other) transporter family, has high similarity to uncharacterized human FLJ20371 This gene encodes a protein predicted by Eisenberg and coworkers, with 52% accuracy, to be mitochondrial. C09D4.2 C09D4.2 Protein of unknown function C09D4.3 C09D4.3 Protein containing a protein kinase domain, has low similarity to casein kinase 1 gamma 3 (rat Csnk1g3), which is a serine-threonine protein kinase that may play roles in cell growth and in morphogenesis SER/THR protein kinase C09D4.4 C09D4.4 Protein of unknown function C09D4.5 C09D4.5 Protein with high similarity to ribosomal protein L19 (S. cerevisiae Rpl19bp), which is a structural ribosomal protein, contains a ribosomal L19e domain, which are present in the large ribosomal subunit 60S ribosomal protein L19; rpl-19 encodes a large ribosomal subunit L19 protein. C09D4.6 C09D4.6 Protein of unknown function C09D8.2 ptp-3;C09D8.1;C09D8.2 Member of the protein-tyrosine phosphatase family, contains twelve fibronectin type III domains and three immunoglobulin domains, has moderate similarity to protein tyrosine phosphatase receptor type D (human PTPRD) C09E10.2 C09E10.2 Putative ortholog of C. elegans dgk-1 gene product diacylglycerol kinase; The dgk-1 gene encodes an ortholog of diacylglyerol kinase that affects movement, egg laying, and synaptic transmission; it genetically interacts with the goa-1 and egl-30 signaling pathways, and is expressed in neurons. C09E7.1 C09E7.1 Putative ortholog of C. elegans C09E7.G gene product 7TM chemoreceptor, srxa family C09E7.2 C09E7.2 Putative ortholog of C. elegans C09E7.G gene product PQN-10 encodes an unfamiliar protein, with limited similarity to F27B3.6, that has a glutamine/asparagine-rich domain. C09E7.3 C09E7.3 Putative ortholog of C. elegans C09E7.F gene product C09E7.4 C09E7.4 Putative ortholog of C. elegans C09E7.E gene product C09E7.5 C09E7.5 Protein with strong similarity to C. elegans C09E7.9 gene product C09E7.6 C09E7.6 Putative ortholog of C. elegans C09E7.C gene product C09E7.7 C09E7.7 Putative ortholog of C. elegans C09E7.B gene product C09E7.8 C09E7.8 Putative ortholog of C. elegans C09E7.A gene product C09E7.9 C09E7.9 Putative ortholog of C. elegans C09E7.C gene product C09E8.1 C09E8.1 Putative transporter, has weak similarity to a number of human and C. elegans transporters C09E8.2 C09E8.2 Member of the class 2 lipase family, has moderate similarity to uncharacterized C. elegans F58G1.5 C09E8.3 C09E8.3 Protein of unknown function, has moderate similarity to uncharacterized C. elegans W02B8.3 C09E9.1 C09E9.1 Protein of unknown function, has weak similarity to DNA-directed RNA polymerase subunit A' of Thermococcus celer, has weak similarity to human lung cancer candidate FUS1 C09E9.2 C09E9.2 Protein of unknown function, has high similarity to uncharacterized C. elegans F38A1.13 C09F12.1 C09F12.1 Protein of unknown function, has low similarity to uncharacterized C. elegans T05A10.2 clc-1 encodes a claudin homolog, closely similar to CLC-2, that is required for normal cohesion of apical junctions in epithelia; claudins are integral membrane proteins with four transmembrane sequences that are found in mammalian tight junctions (TJs), induce TJs when transgenically expressed in cells normally lacking them, and can mediate the specific conductance of of specific ions (e.g., magnesium or calcium) through TJs while blocking the flow of water; CLC-1 maintains the impermeability ('barrier function') of epithelia, since clc-1(RNAi) animals have abnormal permeability of the pharynx to dyes; clc-1 is expressed in spermatheca, pharynx, intestine, hypodermis, the excretory-secretory system, and the cell-cell junctions of the vulva; in pharyngeal cells, CLC-1 colocalizes with AJM-1 in long thin lines, parallel to the pharyngeal axis and lining the lumenal surface, that appear to correspond with apical intercellular junctions. C09F12.2 C09F12.2 Protein of unknown function C09F5.1 C09F5.1 Protein with strong similarity to C. elegans W01C9.3 gene product C09F5.2 C09F5.2 Protein of unknown function C09F5.3 C09F5.3 Protein containing seven C2H2 type zinc finger domains, which bind nucleic acids, has weak similarity to a region of OLF1-EBF associated zinc finger protein (human OAZ), which may partner with either Smads or Olf1-EBF to regulate transcription C09F9.1 C09F9.1 Protein of unknown function, has high similarity to uncharacterized C. elegans F38A5.8 C09F9.2 C09F9.2 Protein containing three trypsin inhibitor-like cysteine rich domains C09F9.3 C09F9.3 Protein containing four ankyrin (Ank) repeats, which may mediate protein-protein interactions, has a region of high similarity to breast cell glutaminase (phosphate-activated glutaminase, human GA), which is involved in glutamine metabolism Ank repeat C09F9.4 C09F9.4 Putative ortholog of C. elegans C09F9.2 gene product C09F9.5 C09F9.5 Protein containing two ankyrin (Ank) repeats, which may mediate protein-protein interactions, has a region of high similarity to a region of breast cell glutaminase (phosphate-activated glutaminase, human GA), which is involved in glutamine metabolism C09G1.1 C09G1.1 Protein of unknown function PQN-11 encodes an unfamiliar protein with a glutamine/asparagine-rich domain that is dispensable for viability and gross morphology. C09G1.2 C09G1.2 Protein of unknown function, has similarity to coiled-coil proteins, has similarity over the N-terminal region to C. elegans D1044.6 C09G1.3 C09G1.3 Protein of unknown function C09G1.4 C09G1.4 Protein with weak similarity to S. cerevisiae SCD5 (Multicopy suppressor of clathrin deficiency) C09G12.1 C09G12.1 Protein containing a homeobox (homeodomain) domain, which are found in transcription factors, has a region of moderate similarity to a region of mouse Arix, which may regulate neurotransmitter identity and sympathetic neuron development homeobox protein; C09G12.1 encodes a paired-like homeodomain protein of the K50 class, which has no obvious function in mass RNAi assays. C09G12.2 C09G12.2 Protein containing a DUF216 domain of unknown function, has high similarity to uncharacterized C. elegans K03D3.1 7TM chemoreceptor, srz family C09G12.3 C09G12.3 Protein containing a DUF216 domain of unknown function, has high similarity to uncharacterized C. elegans C09G12.2 7TM chemoreceptor, srz family C09G12.4 C09G12.4 Protein containing a DUF216 domain of unknown function, has high similarity to uncharacterized C. elegans C09G12.2 C09G12.5 C09G12.5 Protein of unknown function, has strong similarity to uncharacterized C. elegans K03D3.5 C09G12.6 C09G12.6 Protein containing three DUF216 domains of unknown function 7TM chemoreceptor, srz family C09G12.7 C09G12.7 Protein of unknown function, has strong similarity to uncharacterized C. elegans C04F12.2 transposase C09G12.8 C09G12.8 Putative ortholog of C. elegans ced-10 gene product RAS-related protein; ced-10 encodes a GTPase orthologous to human RAC1 (OMIM:602048) that is required for phagocytosis during programmed cell death and for migration of the distal tip cells of the somatic gonad; CED-10 functions in the engulfing cell during apoptosis, and is activated by a complex of CED-2(CrkII) and CED-5(DOCK180) to promote formation of the polarized cell extensions associated with cell corpse engulfment. C09G12.9 C09G12.9 Protein with moderate similarity to tumor susceptibility gene 101 (human TSG101), which acts as a transcriptional corepressor that inhibits ubiquitination and is associated with various malignancies upon gene mutation C09G12.9 is orthologous to the human gene TUMOR SUSCEPTIBILITY GENE 101 (TSG101; OMIM:601387), which when mutated leads to disease. C09G4.1 hyl-1;LAG1-1;lag1Ce-1;C09G4.1 Protein of unknown function, has a region of low similarity to a region of S. cerevisiae Lag1p, which is required with S. cerevisiae Lac1p for ceramide synthesis and ER-to-Golgi transport of GPI-anchored proteins and indirectly affects cell longevity hyl-1 encodes a predicted transmembrane protein that is related to Saccharomyces cerevisiae LAG1 (longevity assurance gene), a protein preferentially expressed in young yeasts; by homology, HYL-1 is predicted to have several possible functions, including regulation of lipid, particularly ceramide, biosynthesis, regulation of lipid transport, and regulation of protein translocation in the endoplasmic reticulum; in C. elegans, however, neither the precise role of HYL-1 in development and/or behavior nor the hyl-1 expression pattern is yet known. C09G4.2 C09G4.2 Protein containing a protein kinase domain, a cyclic nucleotide-binding domain, and a protein kinase C-terminal domain, has moderate similarity to cGMP-dependent protein kinase type 1 (human PRKG1), which relaxes vascular smooth muscle cAMP-dependant protein kinase C09G4.3 cks-1;dom-6;C09G4.3 Member of the highly conserved cyclin-dependent kinase regulatory subunit protein family cyclin-dependent kinase regulatory subunit; A homolog of Cks/Suc1, a highly conserved member of the eukaryotic cell cycle machinery that affects both meiosis and mitosis and has a role in the inactivation of the M-phase promoting factor (MPF) during early embryogenesis. C09G4.5 mes-6;C09G4.4;C09G4.5 WD-40 repeat protein with similarity to human and mouse EED (embryonic ectoderm development protein) and D. melanogaster ESC (extra sexcombs) mes-6 encodes a WD repeat-containing protein that is orthologous to Drosophila Extra sex combs (Esc); as a member of a Polycomb-like chromatin repressive complex with MES-2 and MES-3, MES-6 is required maternally for normal germline development and during larval development, for anteroposterior patterning; during germline development, the MES-2/MES-3/MES-6 complex is believed to be essential for maintaining repression of the X chromosome, and in transgenic animals, the complex is necessary for germline repression of repetitive transgenes; in axial patterning, the MES-2/MES-3/MES-6 complex is required in somatic tissues for maintaining homeotic gene repression, acting upstream of the Hox genes lin-39, mab-5, and egl-5, as well as the egl-5 target gene lin-32; MES-6 expression is detected in the nuclei of all cells during early embryogenesis, in the germline precursors Z2 and Z3 and faintly in some somatic cells during late embryogenesis and the L1 larval stage, widely in later larvae, and in germline and oocyte nuclei in adults; normal MES-6 distribution is dependent upon wild-type activity of MES-2 and MES-3, and likewise, distribution of MES-3 is dependent upon wild-type activity of MES-2 and MES-6. C09G5.1 gbr-4;C09G5.1 Protein containing neurotransmitter-gated ion-channel ligand binding and transmembrane domains, has moderate similarity to glycine receptor subunit alpha 3 (human GLRA3), which is the ligand-binding subunit of neuronal glycine-gated chloride channels gamma-aminobutyric-acid receptor (beta-1 subunit); ggr-1 encodes a predicted member of the GABA/ glycine receptor family of ligand-gated chloride channels that affects thermotaxis; expressed in AIB, PVR, PVQ, AVH, and SMDV neurons and in some motor neurons in the ventral cord, and in the egg-laying muscles. C09G5.2 C09G5.2 Member of the putative diphthamide synthesis protein family, has low similarity to diphtheria toxin resistance protein (S. cerevisiae Dph2p), which is required for diphthamide biosynthesis Diphthamide biosynthesis protein (diptheria resistance protein); C09G5.2 encodes an ortholog of S. cerevisiae DPH2/YKL191W and human DPH2L2 (OMIM:603456); C09G5.2 is a putative protein component of diphtamide synthesis; C09G5.2 has no obvious function in mass RNAi assays. C09G5.3 C09G5.3 Protein containing two collagen triple helix repeats, which are found in some extracellular proteins, and a nematode cuticle collagen N-terminal domain, has a region of high similarity to a region of C. elegans BLI-1 collagen C09G5.4 C09G5.4 Protein containing two collagen triple helix repeats, which are found in some extracellular proteins, and a nematode cuticle collagen N-terminal domain, has a region of high similarity to a region of C. elegans BLI-1 collagen; col-39 encodes a collagen that is individually dispensable for viability and gross morphology in mass RNAi screens; the amino- and carboxyl-terminal cysteine-rich regions of COL-39 are most closely related to those of COL-8, COL-19, and COL-35. C09G5.5 C09G5.5 Protein containing three collagen triple helix repeats, which are found in some extracellular proteins, and a nematode cuticle collagen N-terminal domain, has a region of moderate similarity to a region of C. elegans BLI-1 collagen C09G5.6 bli-1;C09G5.6 Member of the collagen triple helix repeat (20 Copies) protein family collagen; The bli-1 gene encodes an unusual cuticular collagen that is required for proper strut formation within the unique medial layer of the adult cuticle; bli-1 interacts genetically with other cuticular collagens such as bli-2 and rol-1, and may be processed for secretion by BLI-4, a Kex2/subtilisin serine endoproteinase; consistent with its role in adult cuticle formation, bli-1 mRNA is highly expressed only during the L4 larval stage. C09G5.7 C09G5.7 Protein of unknown function, has moderate similarity to uncharacterized C. elegans C54G4.2 C09G5.8 C09G5.8 Putative ortholog of C. elegans C52A11.1 gene product C09G9.1 C09G9.1 Protein of unknown function C09G9.2 C09G9.2 Protein containing three WD domains (WD-40 repeat), which may mediate protein-protein interactions C09G9.3 C09G9.3 Protein containing one C. elegans C-terminal C6 domain, which contain conserved cysteine residues C09G9.4 C09G9.4 Protein containing three pyridoxal-dependent group II decarboxylase conserved domains, which bind pyridoxal-phosphate groups, has weak similarity to dopa decarboxylase (aromatic L-amino acid decarboxylase, mouse Ddc) aromatic-L-amino-acid decarboxylase C09G9.5 C09G9.5 Protein of unknown function C09G9.6 C09G9.6 Protein containing two CCCH-type zinc finger domains, which bind DNA or RNA, has a region of high similarity to a region of C. elegans MEX-1, which is a highly conserved eukaryotic germline protein required for differentiation of some cell lineages Zinc finger protein; The oma-1 gene encodes a zinc finger protein of the TIS11 finger type that is paralogous to OMA-2; while either oma-1 or oma-2 individually have no obvious mutant phenotype, a normal copy of at least one of these genes is required for oocyte maturation. C09G9.7 C09G9.7 One member of a four protein Pax-like gene family, the Npax family, in C. elegans; the protein contains only the N-terminal PAI subdomain of the Paired domain 'Paired box' domain C09H10.1 C09H10.1 Protein of unknown function C09H10.10 C09H10.10 Protein of unknown function C09H10.2 C09H10.2;2L388 Protein with high similarity to ribosomal protein L42 (S. cerevisiae Rpl42bp), which is involved in replication of M1 and M2 double-stranded RNA (dsRNA) viruses, member of the ribosomal L44 family, which are part of the large ribosomal subunit 60S ribosomal protein; rpl-41 encodes a large ribosomal subunit L41 protein; by homology, RPL-41 is predicted to function in protein biosynthesis. C09H10.3 nuo-1;C09H10.3 NADH-ubiquinone oxidoreductase of complex I of the mitochondrial respiratory chain; required for embryogenesis and normal growth, movement, phayrngeal pumping and defecation NADH-ubiquinone oxidoreductase; The nuo-1 gene encodes a mitochondrial NADH-ubiquinone oxidoreductase required for progression through development; nuo-1 is orthologous to the human gene NADH DEHYDROGENASE (UBIQUINONE) FLAVOPROTEIN 1 (NDUFV1; OMIM:161015), which when mutated leads to Leigh syndrome (OMIM:256000). C09H10.4 C09H10.4 Protein of unknown function C09H10.5 C09H10.5 Protein of unknown function, has moderate similarity to uncharacterized C. elegans T25B6.3 C09H10.6 C09H10.6 Protein of unknown function, has moderate similarity to uncharacterized C. elegans C50B6.2 histone binding protein C09H10.7 C09H10.7 Protein of unknown function C09H10.8 C09H10.8 Protein of unknown function C09H10.9 C09H10.9 Protein of unknown function, has weak similarity to uncharacterized C. elegans C14C11.1 C09H5.1 C09H5.1 Protein of unknown function C09H5.2 C09H5.2 Member of the E1-E2 ATPase and haloacid dehalogenase families, contains cation transporting ATPase C-terminal and N-terminal domains, has moderate similarity to H+/K+ transporting ATPase alpha polypeptide (mouse Atp4a), which is a gastric proton pump ATPase C09H5.3 C09H5.3 Member of the 7-transmembrane chemoreceptor family of G protein-coupled receptors (GPCR), has low similarity to C. elegans ODR-10, which is a G protein-coupled receptor involved in odorant response 7TM chemoreceptor, str family C09H5.4 C09H5.4 Member of the 7-transmembrane chemoreceptor family of G protein-coupled receptors (GPCR), has low similarity to C. elegans ODR-10, which is a G protein-coupled receptor involved in odorant response 7TM chemoreceptor, str family C09H5.5 C09H5.5 Member of the 7-transmembrane chemoreceptor family of G protein-coupled receptors (GPCR), has low similarity to C. elegans ODR-10, which is a G protein-coupled receptor involved in odorant response 7TM chemoreceptor, str family C09H5.6 C09H5.6 Member of the 7-transmembrane chemoreceptor family of G protein-coupled receptors (GPCR), has low similarity to C. elegans ODR-10, which is a G protein-coupled receptor involved in odorant response 7TM chemoreceptor, str family C09H5.7 C09H5.7 Protein with high similarity to S. cerevisiae Glc7p, which is a protein serine or threonine phosphatase and required for glucose repression, membrane bilayer mixing, and vesicular trafficking, contains a serine or threonine protein phosphatase domain phophatase C09H5.9 C09H5.9 Member of the 7-transmembrane chemoreceptor family of G protein-coupled receptors (GPCR), has low similarity to C. elegans ODR-10, which is a G protein-coupled receptor involved in odorant response 7TM chemoreceptor, str family C09H6.1 C09H6.1 Protein containing seventeen C2H2 type zinc finger domains, which bind nucleic acids, has a region of weak similarity to a region of restrictive element silencer transcription factor (rat Rest), which is a DNA-binding protein that silences transcription Zinc finger, C2H2 type (11 domains) C09H6.2 lin-10;C09H6.2 Member of PTB, PDZ domain-containing family of proteins; strongly similar over C-terminal half to human amyloid beta (A4) precursor protein-binding proteins (APBA1, APBA2, APBA3); required for determination of vulva cell fate Phosphotyrosine interaction domain (PTB/PID)., PDZ domain (Also known as DHR or GLGF). (2 domains); The lin-10 gene encodes a PDZ and PTB domain-containing protein that is homologous to mammalian Munc interacting proteins (Mint1, OMIM:602414) and is required for polarized protein localization; LIN-10 is required for proper localization of the LET-23 EGF receptor to the basolateral membrane of the vulval precursor cells and for proper postsynaptic localization of GLR-1, an AMPA-type glutamate receptor in interneurons; LIN-10 is detected in the cytoplasm, membrane, and at particularly high levels in the Golgi. C09H6.3 C09H6.3 Protein of unknown function, has weak similarity to uncharacterized human KIAA0892 C10A4.1 C10A4.1 Protein of unknown function, has moderate similarity to uncharacterized C. elegans K09A11.1 transposase HFL1 (D. melanogaster) C10A4.2 C10A4.2 Protein of unknown function C10A4.3 C10A4.3 Protein of unknown function C10A4.4 C10A4.4 Protein of unknown function C10A4.5 C10A4.5 Protein of unknown function C10A4.6 C10A4.6 Protein of unknown function C10A4.7 C10A4.7 Protein of unknown function C10A4.8 C10A4.8 Protein containing three C2H2 type zinc finger domains, which bind nucleic acids, has a region of high similarity to a region of zinc finger protein 85 (human ZNF85), which functions as a transcriptional co-repressor Zinc finger protein C10B5.1 C10B5.1 Protein containing three WD domains (WD-40 repeat), which may mediate protein-protein interactions C10B5.3 C10B5.3 Protein of unknown function C10C5.1 C10C5.1 Protein of unknown function, has moderate similarity to H. sapiens Hs.79077 gene product C10C5.2 C10C5.2 Protein containing an F-box domain, which serve as a link between a target protein and a ubiquitin-conjugating enzyme C10C5.3 C10C5.3 Protein with high similarity to aminoacylase 1 (human ACY1), which catalyzes the hydrolysis of N-alpha-acylated amino acids and may contribute to formation of small cell lung cancer, member of the M20, M25, or M40 peptidase family of zinc metalloproteases aminoacylase-1 C10C5.4 C10C5.4 Protein with high similarity to aminoacylase 1 (human ACY1), which catalyzes the hydrolysis of N-alpha-acylated amino acids and may contribute to formation of small cell lung cancer, member of the M20, M25, or M40 peptidase family of zinc metalloproteases aminoacylase-1 C10C5.5 C10C5.5 Protein with high similarity to aminoacylase 1 (human ACY1), which catalyzes the hydrolysis of N-alpha-acylated amino acids and may contribute to formation of small cell lung cancer, member of the M20, M25, or M40 peptidase family of zinc metalloproteases aminoacylase-1 C10C5.6 C10C5.6 Putative ortholog of S. cerevisiae Yhr186p, an essential protein of unknown function Yeast YHY6 like; daf-15 is required for non-dauer development, at least in some tissues or stages; daf-15(m81) mutants constitutively and irreversibly form abnormal dauer-like larvae (and are thus effectively lethal/sterile); mutants do not form true dauers when exposed to dauer pheromone, yet execute only two molts; daf-15 is uncloned. C10C6.1 kin-4;C10C6.1 Protein containing protein kinase and PDZ, DHR, or GLGF domains, has moderate similarity to a region of mouse Mtssk, which is a microtubule associated testis specific serine/threonine protein kinase that may play a role in spermatid maturation serine/threonine kinase C10C6.2 C10C6.2 Member of the rhodopsin family of G protein-coupled receptors (GPCR), has low similarity to C. elegans NPR-1, which is involved in locomotory behavior G-protein coupled receptor C10C6.3 C10C6.3 Protein of unknown function, has high similarity to uncharacterized C. elegans C15H7.4 C10C6.5 C10C6.5 Member of the ABC transporter family, which are involved in translocation across biological membranes, has low similarity to ATP-binding cassette subfamily G member 2 (human ABCG2), which is a transporter involved in development of multidrug resistance ATP binding transport protein C10C6.6 C10C6.6 Member of the haloacid dehalogenase or epoxide hydrolase family and the E1-E2 (P-type) ATPase family, has moderate similarity to S. cerevisiae Spf1p, which is a putative Ca2+-transporting ATPase involved in toxin resistance E1-E2 ATPase C10E2.1 C10E2.1 Protein of unknown function C10E2.2 C10E2.2 Protein of unknown function This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins. C10E2.3 C10E2.3 Member of the histone deacetylase family, which catalyze removal of acetyl groups from histones, has a region of high similarity to a region of histone deacetylase 4 (human HDAC4), which acts as a corepressor of human MEF2 dependent transcription C10E2.4 C10E2.4 Protein of unknown function C10E2.5 C10E2.5 Protein of unknown function C10E2.6 C10E2.6 Member of the sugar (and other) transporter family, has low similarity to solute carrier family 16 member 4 (human SLC16A4), which is a proton-dependent lactate transport protein sugar transporter C10F3.1 C10F3.1 Protein of unknown function, has weak similarity to human AGC1,a chondroitin sulfate proteoglycan C10F3.2 C10F3.2 Putative retinol dehydrogenase alcohol/ribitol dehydrogenase; dhs-16 encodes a short-chain dehydrogenase predicted to be mitochondrial. C10F3.3 acy-2;C10F3.3 Putative adenylyl cyclase adenylate cyclase; An intragenic deletion of acy-2 is lethal at the first larval stage of development; the terminal phenotype resembles that seen in loss-of-function gsa-1 mutants. C10F3.4 C10F3.4 Protein of unknown function C10F3.5 pcm-1;C10F3.5 L-Isoaspartyl (D-aspartate) O-Methyltransferase L-isoaspartyl/D-aspartyl methyltransferase C10F3.6 C10F3.6 Protein containing a Src homology 3 domain, has a region of moderate similarity to fucosyltransferase 8 (alpha (1,6) fucosyltransferase, human FUT8), which acts in asparagine-linked oligosaccharide synthesis and may be associated with carcinogenesis C10G11.1 C10G11.1 Protein of unknown function, has high similarity to uncharacterized C. elegans C10G11.10 C10G11.10 C10G11.10 Protein of unknown function, has high similarity to uncharacterized C. elegans C10G11.1 C10G11.2 C10G11.2 Member of the 7-transmembrane chemoreceptor family of G protein-coupled receptors (GPCR), has high similarity to uncharacterized C. elegans C10G11.3 7TM chemoreceptor, srh family C10G11.3 C10G11.3 Member of the 7-transmembrane chemoreceptor family of G protein-coupled receptors (GPCR), has high similarity to uncharacterized C. elegans C10G11.2 7TM chemoreceptor, srh family C10G11.4 C10G11.4 Member of the 7-transmembrane chemoreceptor family of G protein-coupled receptors (GPCR), has high similarity to uncharacterized C. elegans C10G11.2 7TM chemoreceptor, srh family C10G11.5 C10G11.5 Protein with moderate similarity to S. cerevisiae Ydr531p, which is a putative pantothenate kinase involved in coenzyme A biosynthesis C10G11.6 C10G11.6 Protein of unknown function C10G11.7 C10G11.7 Protein of unknown function C10G11.8 C10G11.8 Member of the proteasome complex protein family ATPase C10G11.9 C10G11.9 Protein of unknown function, has very strong similarity to uncharacterized C. elegans T27A3.4 C10G6.1 C10G6.1 Protein containing a 3'-5' exonuclease domain, which catalyze the hydrolysis of mismatched or unpaired nucleotides C10G8.1 C10G8.1 Member of the C. elegans Srg family of integral membrane proteins, which may be involved in chemosensation, has low similarity to uncharacterized C. elegans T09D3.5 7TM chemoreceptor, srg family C10G8.2 C10G8.2 Protein containing a kunitz or bovine pancreatic trypsin inhibitor domain, has low similarity to uncharacterized C. elegans K11D12.6 C10G8.3 C10G8.3 Protein containing a kunitz or bovine pancreatic trypsin inhibitor domain, has low similarity to uncharacterized C. elegans K11D12.7 C10G8.4 C10G8.4 Protein containing a trypsin inhibitor-like cysteine rich domain, has moderate similarity to uncharacterized C. elegans Y69H2.5 C10G8.5 C10G8.5 Protein with high similarity to sodium-calcium exchanger 3 (rat Ncx3), which is a sodium-calcium antiporter, member of the sodium or calcium exchanger protein family of membrane transporters, which regulate intracellular Ca2+ concentrations sodium/calcium exchanger protein 1 C10G8.6 ceh-34;C10G8.6 Protein with high similarity to sine oculis homeobox (Drosophila) homolog 1 (human SIX1), which is a putative transcription factor that plays a role in cell cycle checkpoint, contains a homeobox (homeodomain) domain homeobox protein; ceh-34 encodes a homeodomain protein, homologous to human SIX2 (OMIM:604994), that is expressed very weakly in the pharynxes of late embryos and early larvae; it has no known function. C10G8.7 ceh-33;C10G8.7 Protein containing a homeobox (homeodomain) domain, has a region of high similarity to a region of sine oculis homeobox (Drosophila) homolog 1 (human SIX1), which is a putative transcription factor that plays a role in cell cycle checkpoint a homeodomain transcription factor of the six/sine oculis (so) gene family; affects gonad formation, and is expressed in the pharynx. C10G8.8 C10G8.8 Protein of unknown function C10H11.1 C10H11.1 Protein containing a villin headpiece domain, which bind F-actin and are required for F-actin bundling and actin reorganization, has low similarity to a region of supervillin (human SVIL), which links filamentous actin with the plasma membrane C10H11.10 C10H11.10 Putative ortholog of C. elegans M04F3.3 gene product C10H11.2 C10H11.2 Member of the transposase family, which are required for excising and inserting mobile genetic elements, has very strong similarity to uncharacterized C. elegans ZK546.8 C10H11.3 C10H11.3 Protein containing two UDP-glucoronosyl and UDP-glucosyl transferase domains, has weak similarity to UDP glycosyltransferase 1 family polypeptide A1 (human UGT1A), which acts in bilirubin conjugation and has a role in Gilbert and Crigler-Najjar syndromes C10H11.4 C10H11.4 Protein containing two UDP-glucoronosyl and UDP-glucosyl transferase domains, has low similarity to UDP-glycosyltransferase 1 A9 (human UGT1A9), which converts hydrophobic xenobiotic and endobiotic compounds to hydrophilic compounds for removal from cell C10H11.5 C10H11.5 Protein containing a UDP-glucoronosyl and UDP-glucosyl transferase domain, has low similarity to UDP glycosyltransferase 1 A3 (human UGT1A3), which converts hydrophobic xenobiotic and endobiotic compounds to hydrophilic compounds for removal from cell C10H11.6 C10H11.6 Protein containing two UDP-glucoronosyl and UDP-glucosyl transferase domains, has low similarity to UDP glycosyltransferase 1 family polypeptide A1 (human UGT1A), which acts in bilirubin conjugation and has a role in Gilbert and Crigler-Najjar syndromes C10H11.7 C10H11.7 Protein containing a major sperm protein (MSP) domain, which are involved in sperm motility C10H11.8 C10H11.8 Protein containing six WD domains (WD-40 repeat), which may mediate protein-protein interactions, has low similarity to S. cerevisiae Lst8p, which is a protein required for transport of permeases from the Golgi to the plasma membrane C10H11.9 let-502;C10H11.9 Serine/threonine protein kinase required for embryonic elongation; putative ortholog of ROCK2 and ROCK1 rho-associated protein kinases, has strong similarity to D. melanogaster GEK protein, which is a putative effector for CDC42 function Rho-associated kinase; let-502 encodes Rho-binding Ser/Thr kinase orthologous to human myotonic dystrophy kinase (DM-kinase), and is required for early embryonic cleavages, embryonic elongation, migration of hypodermal P cells to a ventral position, normal spermathecal contraction, and fertility; LET-502 is required for hypodermal cells to properly change their shape, and is expressed in those cells, during embryonic elongation; let-502 mutations are suppressed by mel-11 mutations, and the pattern of LET-502 expression in the embryonic epidermis and the spermatheca is opposite to that of MEL-11, indicating that LET-502 and MEL-11 have opposing functions (presumably tissue contraction and relaxation); MEL-11 requires LET-502 (along with the nonmuscle myosin NMY-1) for proper localization. C11D2.1 C11D2.1 Protein of unknown function, has moderate similarity to C. elegans D2024.9 C11D2.2 C11D2.2 Protein with high similarity to C. elegans ASP-6, which is an aspartyl protease involved in protein degradation, member of the aspartyl (acid) protease family, which include pepsins, cathepsins and renins protease C11D2.3 C11D2.3 Protein of unknown function C11D2.4 C11D2.4 Protein containing a PUA (pseudouridine synthase and archaeosine transglycosylase) domain, which may bind RNA, has a region of high similarity to human MCT-1, which is involved in cell cycle regulation and may be associated with T-cell malignancy C11D2.5 C11D2.5 Protein of unknown function, has high similarity to uncharacterized C. elegans F17C8.6 C11D2.6 C11D2.6 Member of the ion transport family, which include calcium, sodium, and potassium channels, has weak similarity to calcium channel alpha 1S subunit (human CACNA1S), which is involved in coupling of excitation and contraction in muscle C11D9.1 C11D9.1 Protein containing a RhoGEF (GTPase exchange factor) domain and a PDZ, DHR, or GLGF domain, which are found in signaling proteins, has a region of low similarity to a region of mouse Tiam2, which is a Rac1-specific guanyl-nucleotide exchange factor C11E4.1 C11E4.1 Member of the glutathione peroxidase family, has moderate similarity to glutathione peroxidase 5 (mouse Gpx5), which is a selenium-independent glutathione peroxidase that protects epididymis and perhaps sperm membranes from peroxidative damage glutathione peroxidase C11E4.2 C11E4.2 Member of the glutathione peroxidase family, has moderate similarity to plasma glutathione peroxidase (human GPX3), which reduces lipid hydroperoxide and hydrogen peroxide in plasma and catalyzes the reduction of tertiary butyl hydroperoxide glutathione peroxidase C11E4.3 C11E4.3 Member of the amiloride-sensitive sodium channel family, which are involved in sodium reabsorption C11E4.4 C11E4.4 Member of the amiloride-sensitive sodium channel family, which are involved in sodium reabsorption C11E4.6 C11E4.6 Protein containing six ankyrin (Ank) repeats and a SAM (sterile alpha motif) domain, which may mediate protein-protein interactions, has a region of low similarity to a region of ankyrin (rat Ank3), which links membrane proteins to the cytoskeleton ankyrin repeats C11E4.7 C11E4.7 Protein of unknown function C11G10.1 C11G10.1 Protein of unknown function C11G10.2 C11G10.2 Protein of unknown function C11G6.1 C11G6.1 Protein of unknown function, has weak similarity to C. elegans Y54E2A.8 taf-3 encodes the C. elegans ortholog of mammalian TAF3(TAFII140), a component of the RNA polymerase II TFIID transcription complex; TAF-3 contains a histone fold-like domain in its N-terminus and by homology, is predicted to function in transcriptional regulation; however, as loss of taf-3 activity via large-scale RNAi screens does not result in any obvious abnormalities, the precise role of taf-3 in C. elegans development and/or behavior is not yet known. C11G6.2 C11G6.2 Protein of unknown function, has low similarity to a region of S. cerevisiae Rrm3p, which is a DNA helicase that promotes replication fork progression through the ribosomal DNA helicase like C11G6.3 C11G6.3 Protein containing a putative PHD-type zinc fingerdomain, has weak similarity to human protein kinase STK10 PHD-finger. C11G6.4 nhr-28;C11G6.4 Member of the nuclear hormone receptor/Zinc finger protein family nuclear hormone receptor, nhr-28 C11H1.1 C11H1.1 Protein containing a type 1 thrombospondin domain C11H1.2 C11H1.2 Protein of unknown function, has high similarity to uncharacterized C. elegans Y75B8A.16 C11H1.3 C11H1.3 Protein containing a C3HC4 type (RING) zinc finger, which may mediate protein-protein interactions, has low similarity to uncharacterized human KIAA0544 Zinc finger, C3HC4 type (RING finger) C11H1.4 C11H1.4 Putative ortholog of C. elegans C11H1.6 gene product peroxisome biosynthesis protein like; prx-1 encodes a predicted peroxin, a subfamily 2 member of the AAA (ATPases Associated with diverse cellular Activities) family that affects growth in one large-scale RNAi screen; expressed in intestinal cells throughout development. C11H1.5 C11H1.5 Protein of unknown function, has weak similarity to uncharacterized C. elegans F20G2.3 C11H1.6 C11H1.6 Member of the proteasome complex protein family C11H1.7 C11H1.7 Protein of unknown function C12C8.1 C12C8.1 Protein with high similarity to heat shock 70kD protein 8 (human HSPA8), which is elevated in the hearts of patients with hypertrophic cardiomyopathy, member of the Hsp70 family, which are stress-induced protein chaperones heat shock protein 70; hsp-70 encodes a member of the hsp70 family. C12C8.2 C12C8.2 Member of the cysteine-methionine metabolism pyridoxal-phosphate-dependent enzyme family, has moderate similarity to cystathionase (human CTH), which is a pyridoxal phosphate-dependent enzyme that acts in the cysteine metabolic pathway L-methionine-alpha-deamino-gamma-mercaptomethane lyase C12C8.3 lin-41;C12C8.3 RING finger-containing protein that acts in the heterochronic patterning pathway The lin-41 gene encodes a novel RBCC (Ring finger-B box-Coiled coil) protein that is a member of the NHL (NCL-1, HT2A, and LIN-41) family of proteins and is required for the proper temporal control of specific postembryonic cell fates; lin-41 translation is negatively regulated during L4 and adult stages by let-7, a small temporally regulated RNA (stRNA) that is complementary to two sites in the lin-41 3'UTR; LIN-41 is a widely expressed cytoplasmic protein and negatively regulates post-transcriptional expression of LIN-29, a transcription factor required for adult cell fates. C12D12.1 C12D12.1 Protein of unknown function, has a region of low similarity to a region of nascent-polypeptide-associated complex alpha subunit (mouse Naca), which binds JUN, enhances JUN-mediated transcription, and functions in myogenesis C12D12.2 glt-2;Ceglut-2;C12D12.2 Putative glutamate transporter excitatory amino acid transporter; glt-1 encodes a predicted plasma membrane glutamate transporter that is functional when expressed in Xenopus oocytes; expressed in the M3 pharyngeal neuron, the male tail, some anterior hypodermal cells, and in cells in the terminal bulb of the pharynx. C12D12.3 C12D12.3 Protein of unknown function C12D12.4 C12D12.4 Protein of unknown function C12D12.5 C12D12.5 Protein containing a high mobility group box (HMG 1 or 2) family domain, has a region of high similarity to a region of SRY (sex determining region Y)-box 20 (human SOX20), which may regulate male gonad development C12D12.6 C12D12.6 Member of the reverse transcriptase protein family, which are RNA-dependent DNA polymerases, has high similarity to uncharacterized C. elegans T05F1.12 C12D5.10 C12D5.10 Protein of unknown function, has low similarity to uncharacterized C. elegans C12D5.9 C12D5.2 C12D5.2 Protein containing a nuclear hormone receptor C4-type zinc finger domain, which bind DNA and may be involved in regulation of transcription, and a nuclear hormone receptor ligand-binding domain, has weak similarity to pregnane X receptor (mouse Nr1i2) zinc finger protein C12D5.3 C12D5.3 Protein of unknown function, has high similarity to uncharacterized C. elegans B0294.1 C12D5.4 C12D5.4 Protein of unknown function, has low similarity to uncharacterized C. elegans B0294.1 C12D5.5 C12D5.5 Protein of unknown function, has moderate similarity to uncharacterized C. elegans B0294.1 C12D5.7 C12D5.7 Putative cytochrome P450 cytochrome P450 C12D5.8 nhr-94;C12D5.8 Member of the C. elegans Sre G protein-coupled chemoreceptor family, contains one nuclear hormone receptor C4-type zinc finger and one nuclear hormone receptor ligand-binding domain, has a region of low similarity to a region of C. elegans NHR-58 C12D5.9 C12D5.9 Protein of unknown function, has moderate similarity to uncharacterized C. elegans R13D7.2 C12D8.1 C12D8.1 Protein containing eight KH domains, which may bind RNA, has moderate similarity to KH-type splicing regulatory protein (FUSE-binding protein 2, human KHSRP), which is a pre-mRNA splicing factor and putative transcription factor RNA binding protein; C12D8.1 encodes two alternative proteins (through alternative splicing), that belong to an ancient family of single-stranded nucleic acid-binding proteins, and that are predicted to regulate gene expression through binding either mRNA or (locally) single-stranded DNA; they is most likely to specifically bind one or more discrete mRNAs and regulate their spatial localization or alternative splicing. C12D8.10 C12D8.10 Putative ortholog of C. elegans akt-2 gene product PH (pleckstrin homology) domain, Protein kinase C terminal domain; akt-1 encodes an ortholog of serine/threonine kinase Akt/PKB; akt-1 genetically interacts with the insulin signaling pathway and is widely expressed; two alleles of akt-1 (sa573 and sa700) have a Daf-c mutant phenotype at 27 degrees C (Hid phenotype). C12D8.11 rop-1;C12D8.11 Ro ribonucleoprotein similar to human and Xenopus Ro60 ROP-1 ribonucleoprotein RO autoantigen C12D8.12 C12D8.12 Member of the 7-transmembrane chemoreceptor family of G protein-coupled receptors (GPCR), has moderate similarity to uncharacterized C. elegans R08C7.7 C12D8.4 C12D8.4 Member of the transthyretin-like family, has high similarity to uncharacterized C. elegans R90.2 Transthyretin-like family C12D8.5 C12D8.5 Protein containing a Rieske iron-sulfur protein 2Fe-2S domain, which bind ubiquinol or plastoquinol anion and transfer electrons to the 2Fe-2S cluster 3-chlorobenzoate-3,4-dioxygenase like C12D8.6 C12D8.6 Protein of unknown function C12D8.8 C12D8.8 Protein containing two collagen triple helix repeats, which are found in some extracellular proteins, and a nematode cuticle collagen N-terminal domain, has low similarity to C. elegans ROL-6 collagen C12D8.9 C12D8.9 Protein of unknown function C13A10.1 C13A10.1 Protein of unknown function C13A10.2 C13A10.2 Protein of unknown function C13A10.3 C13A10.3 Protein containing a Src homology 3 (SH3) domain, has a region of moderate similarity to a region of protein kinase mitogen-activated 8 interacting protein (JNK-interacting protein 1, mouse Prkm8ip), which is a regulator of the JNK signaling pathway C13A2.1 C13A2.1 Protein containing two DUF23 domains of unknown function, has high similarity to uncharacterized C. elegans F07G11.4 C13A2.10 C13A2.10 Member of the domain of unknown function DUF13 family, has strong similarity to uncharacterized C. elegans F07G11.2 C13A2.11 C13A2.11 Protein containing a DUF23 domain of unknown function C13A2.2 C13A2.2 Protein containing a DUF138 domain of unknown function C13A2.3 C13A2.3 Putative ortholog of C. elegans C13A2.7 gene product C13A2.4 C13A2.4 Member of the domain of unknown function DUF13 family, has high similarity to uncharacterized C. elegans C13A2.10 C13A2.5 C13A2.5 Protein containing two DUF23 domains of unknown function, has high similarity to uncharacterized C. elegans C27A7.2 C13A2.6 C13A2.6 Protein containing a DUF23 domain of unknown function, has high similarity to uncharacterized C. elegans K08D9.6 C13A2.7 C13A2.7 Protein of unknown function, has low similarity to uncharacterized C. elegans W08G11.1 C13A2.9 C13A2.9 Member of the domain of unknown function DUF13 family, has strong similarity to uncharacterized C. elegans F07G11.1 C13B4.1 C13B4.1 Protein with strong similarity to C. elegans dao-2 gene product C13B4.2 tgt-1;tgt;C13B4.2 Member of the ubiquitin family and of the ubiquitin carboxyl-terminal hydrolase family 2, contains a ubiquitin carboxyl-terminal hydrolases family 2 domain, has moderate similarity to ubiquitin specific protease 14 (human USP14) Queuine trna-ribosyltransferase; usp-14 encodes a homolog of ubiquitin-specific protease 14 (Usp14), a highly conserved thiol protease that hydrolyzes the peptide bond at the C-terminal glycine of ubiquitin (OMIM:607274, mutations are associated with synaptic defects in ataxia mice); by homology, USP-14 is predicted to function in ubiquitin-mediated protein degradation, or regulation of protein localization or activity; as loss of USP-14 function via RNA-mediated interference (RNAi) does not result in any abnormalities, the precise role of USP-14 in C. elegans development and/or behavior is not yet known. C13B7.6 C13B7.6 Putative ortholog of C. elegans Y45G12C.I gene product C13B7.A C13B7.5;C13B7.A Member of the 7-transmembrane chemoreceptor family of G-protein coupled receptors (GPCR), has low similarity to C. elegans ODR-10, which is a G protein-coupled receptor involved in odorant response C13B7.B C13B7.4;C13B7.B Putative ortholog of C. elegans Y45G12C.9 gene product C13B7.C srd-60;C13B7.3;C13B7.C Protein of unknown function, putative paralog of C. elegans Y45G12C.I C13B7.D C13B7.2;C13B7.D Member of the 7-transmembrane chemoreceptor family of G-protein coupled receptors (GPCR), has low similarity to C. elegans ODR-10, which is a G protein-coupled receptor involved in odorant response C13B9.2 C13B9.2 Protein of unknown function C13B9.3 C13B9.3 Member of the clathrin adaptor complexes medium chain family, which are involved in transport of clathrin-coated vesicles, has low similarity to coatomer (COPI) complex delta chain (delta-COP) of secretory pathway vesicles (S. cerevisiae Ret2p) C13B9.3 encodes a delta subunit of the coatomer (COPI) complex; in mass RNAi assays, C13B9.3 is required for fertility and general health. C13B9.4 C13B9.4 Member of the secretin family of G protein-coupled receptors, contains a hormone receptor domain, has weak similarity to glucagon receptor (human GCGR), which regulates cAMP and calcium levels, glucose production, and insulin secretion C13B9.4 is orthologous to the human gene CALCITONIN RECEPTOR (CALCR; OMIM:114131), which when mutated leads to disease. C13C12.1 cal-1;C13C12.1 Protein containing four EF hand domains, which are found in signaling, buffering or transport proteins, has a region of high similarity to calmodulin 1 (phosphorylase kinase delta, rat Calm1), which is a neuronal cell protein that binds calcium calmodulin like protein; a homolog of calmodulin. C13C12.2 C13C12.2 Protein of unknown function C13C4.1 C13C4.1 Protein containing one nuclear hormone receptor C4-type zinc finger domain and one nuclear hormone receptor ligand-binding domain, has weak similarity to estrogen related receptor gamma (mouse Esrrg), which activates ligand-independent transcription Ligand-binding domain of nuclear hormone receptors, Zinc finger, C4 type (two domains) C13C4.2 C13C4.2 Protein containing a nuclear hormone receptor ligand-binding domain and a nuclear hormone receptor C4-type zinc finger, which may be involved in transcription regulation, has weak similarity to estrogen related receptor gamma (mouse Esrrg) Ligand-binding domain of nuclear hormone receptors, Zinc finger, C4 type (two domains) C13C4.3 C13C4.3 Protein containing a nuclear hormone receptor ligand-binding domain and a nuclear hormone receptor C4-type zinc finger, which bind DNA and may be involved in transcription regulation, has weak similarity to human NR1I2 Ligand-binding domain of nuclear hormone receptors, Zinc finger, C4 type (two domains) C13C4.4 C13C4.4 Member of the haloacid dehalogenase or epoxide hydrolase family, has moderate similarity to uncharacterized human LHPP C13C4.5 C13C4.5 Member of the sugar (and other) transporter family, has a region of weak similarity to a region of S. cerevisiae Hxt2p, which is a high-affinity hexose transporter sugar transporter C13C4.6 C13C4.6 Member of an uncharacterized protein family C13D9.1 C13D9.1 Protein of unknown function, has moderate similarity to uncharacterized C. elegans C13D9.2 C13D9.2 C13D9.2 Protein of unknown function, moderate similarity to uncharacterized C. elegans C13D9.1 C13D9.3 C13D9.3 Protein of unknown function, has high similarity to uncharacterized C. elegans T01G5.4 C13D9.4 C13D9.4 Protein of unknown function, has moderate similarity to uncharcterized C. elegans C13D9.5 7TM chemoreceptor, srsx family C13D9.5 C13D9.5 Protein of unknown function, has high similarity to uncharacterized C. elegans C13D9.6 7TM chemoreceptor, srsx family C13D9.6 C13D9.6 Protein of unknown function, has high similarity to uncharacterized C. elegans C13D9.5 7TM chemoreceptor, srsx family C13D9.7 C13D9.7 Member of the sodium or calcium exchanger protein family of membrane transporters, which regulate intracellular Ca2+ concentrations, has weak similarity to potassium-dependent sodium-calcium exchanger 2 (rat Nckx2), which is a calcium:sodium antiporter C13D9.8 C13D9.8 Member of the sodium or calcium exchanger protein family of membrane transporters, which regulate intracellular Ca2+ concentrations, has weak similarity to potassium-dependent sodium-calcium exchanger 2 (rat Nckx2), which is a calcium:sodium antiporter C13D9.9 C13D9.9 Protein containing two UDP-glucoronosyl and UDP-glucosyl transferase domains, has weak similarity to androsterone UDP-glucuronosyltransferase (rat Ugt2b2), which is a 3-hydroxyandrogen UDP-glucuronosyltransferase acting in androgen metabolism UDP-glucuronosyltransferase C13E3.1 C13E3.1 Protein of unknown function C13F10.1 C13F10.1 Protein of unknown function C13F10.2 C13F10.2 Protein of unknown function, has moderate similarity to H. sapiens Hs.108847 gene product C13F10.4 C13F10.4 Protein of unknown function, has moderate similarity to uncharacterized human KIAA1414 C13F10.5 C13F10.5 Protein of unknown function C13F10.6 C13F10.6 Protein of unknown function C13F10.7 C13F10.7 Protein containing a zinc knuckle domain, which can bind eukaryotic RNA or DNA C13G3.1 C13G3.1 Protein of unknown function C13G3.2 hot-6;C13G3.2 Ly-6-related protein C13G3.3 C13G3.3 Protein with high similarity to mouse Ppp2r5c, which is a regulatory subunit of protein phosphatase 2A, member of the protein phosphatase 2A regulatory B subunit (B56) family proteion phosphatase C13G5.1 ceh-16;C13G5.1 Homeodomain transcription factor, has similarity over 165 amino acids to D. melanogaster EN (engrailed) homeodomain transcription factor Engrailed homeotic protein; ceh-16 encodes a protein that contains a homeobox domain. C13G5.2 C13G5.2 Putative ortholog of C. elegans C03B1.8 gene product C14A11.2 C14A11.2 Protein with moderate similarity to C. elegans ZC21.1 gene product C14A11.3 C14A11.3 Protein containing a RhoGEF (GTPase exchange factor) domain and a pleckstrin homology (PH) domain, which mediate protein-protein and protein-lipid interactions, has low similarity to MCF.2 cell line derived transforming sequence (human MCF2) guanine-nucleotide releasing factor C14A11.4 C14A11.4 Protein of unknown function, has weak similarity in the N-terminus to human KIAA0362 protein (Hs.25515) C14A11.5 C14A11.5 Protein of unknown function C14A11.6 C14A11.6 Protein of unknown function C14A11.7 C14A11.7 Member of the Ras superfamily of GTP binding proteins, has a region of moderate similarity to a region of RAS dexamethasone induced 1 (mouse Rasd1), which is a small GTPase and nucleotide exchange factor involved in NO mediated signal transduction RAS-related protein C14A4.1 C14A4.1 Protein containing two phycobilisome (PBS) lyase HEAT-like repeats, has high similarity to uncharacterized human MGC4293 C14A4.10 taf-6;C14A4.10 Member of the transcription initiation factor IID 18kD subunit family, has a region of moderate similarity to TBP-associated factor RNA polymerase II K 18 (human TAF13), which forms a heterodimer with human TAF11 in the TFIID complex FUN81 protein; taf-13 encodes a predicted member of the transcription initiation factor IID, 18kDa subunit family with similarity to Drosophila Taf13. C14A4.11 C14A4.11 Protein with similarity to human apoptosis-related protein TFAR15 (Hs.28866) C14A4.12 C14A4.12 Protein of unknown function C14A4.13 C14A4.13 Protein containing a protein kinase domain, has low similarity to S. pombe Hhp2p, which is a casein kinase I homolog serine/threonine kinase C14A4.14 C14A4.14 Protein with moderate similarity to D. melanogaster CG12261 (CG12261 gene product) C14A4.2 dap-3;C14A4.2 Similar to human DAP3, death associated protein 3, which is involved in resistance to ionizing radiation dap-3 is an ortholog of mammalian death-associated protein 3 (DAP3), a mitochondrial ribosomal protein that promotes apoptosis. C14A4.3 C14A4.3 Protein with low similarity to S. cerevisiae Alg9p, which is a mannosyltransferase involved in N-glycosylation that catalyzes the transfer of mannose from Dol-P-Man to lipid-linked oligosaccharides C14A4.4 C14A4.4 Protein containing a helicase and RNase D C-terminal (HRDC) domain and a 3'-5' exonuclease domain, has low similarity to S. cerevisiae Rrp6p, which is involved in 5.8S ribosomal RNA 3'end processing autoantigen PM-SCL; crn-3 encodes a cell death-related nuclease, homologous to the 100 kDa polymyositis/scleroderma autoantigen (PM/Scl-100), that is required for normal levels of DNA degradation during apoptosis; PM/Scl-100 is a ribonuclease component of the multiexonuclease exosome complex, which processes or degrades several types of RNAs in yeast; crn-3(RNAi) animals show retarded growth and a low penetrance of embryonic lethality; CRN-3 promotes both DNA degradation and cell corpse engulfment, in a partially redundant pathway that includes CRN-2 but is parallel to CPS-6; CRN-3 is predicted to be mitochondrial. C14A4.5 C14A4.5 Member of the RNase PH family of 3' exoribonucleases, which are involved in RNA processing, has low similarity to uncharacterized human RRP46 Prokaryotic ribonuclease PH C14A4.6 C14A4.6 Protein of unknown function, has weak similarity to C. elegans C14A4.7 C14A4.7 C14A4.7 Protein of unknown function, has weak similarity to C. elegans C14A4.6 C14A4.8 C14A4.8 Protein of unknown function C14A4.9 C14A4.9 Protein of unknown function C14A6.1 C14A6.1 Member of the C-type lectin family, has similarity to human lymphocyte antigen LY75, has similarity to D. melanogaster selectin FW (furrowed) Lectin C-type domain short and long forms (2 domains) C14A6.2 C14A6.2 Protein with similarity to human and D. melanogaster sodium-dependent inorganic phosphate cotransporters C14A6.3 C14A6.3 Protein containing a WSN domain of unknown function C14A6.4 C14A6.4 Member of the transposase family, which are required for excising and inserting mobile genetic elements, has very strong similarity to uncharacterized C. elegans Y95B8A.3 transposase C14A6.5 C14A6.5 Protein with strong similarity to C. elegans W04E12.4 gene product C14A6.6 C14A6.6 Protein of unknown function, has high similarity to uncharacterized C. elegans W04E12.4 C14A6.7 C14A6.7 Protein of unknown function C14A6.8 C14A6.8 Protein of unknown function, has high similarity to uncharacterized C. elegans Y71G12B.3 C14B1.1 pdi-1;C14B1.1 Protein disulfide isomerase, beta subunit of prolyl 4-hydroxylase protein disulfide isomerase; This gene encodes a protein predicted by Eisenberg and coworkers, with 52% accuracy, to be mitochondrial. C14B1.10 C14B1.10 Member of the 2-oxoglutarate (2OG) and Fe(II)-dependent oxygenase family C14B1.2 C14B1.2 Protein of unknown function C14B1.3 C14B1.3 Protein containing a major sperm protein (MSP) domain, which are involved in sperm motility, has weak similarity to uncharacterized F-box only protein 6 (human FBXO6), which is a putative subunit of the SCF ubiquitin ligase complex This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins. C14B1.4 C14B1.4 Protein containing six WD domains (WD-40 repeat), which may mediate protein-protein interactions, has low similarity to platelet-activating factor acetylhydrolase beta subunit (PAF-AH beta, rat Pafah1b1), which inactivates platelet-activating factor guanine nucleotide binding protein C14B1.5 C14B1.5 Member of the Yil103p-like protein family diptheria toxin resistance protein; C14B1.5 encodes an ortholog of S. cerevisiae YIL103 and human DPH2L1/OVCA1 (OMIM:603527, deleted or downregulated in ovarian tumors); C14B1.5 is paralogous to S. cerevisiae DPH2/YKL191W, a protein component of diphtamide synthesis; C14B1.5 has no obvious function in mass RNAi assays. C14B1.6 C14B1.6 Protein of unknown function C14B1.7 C14B1.7 Protein containing a piwi domain and a PAZ (Piwi, Argonaut and Zwille) domain, which may mediate protein-protein interactions, has a region of weak similarity to a region of C. elegans ALG-1, which is involved in the production of LIN-4 small temporal RNA C14B1.8 C14B1.8 Protein of unknown function C14B1.9 C14B1.9 Protein of unknown function C14B4.1 C14B4.1 Protein with strong similarity to C. elegans Y116F11.N gene product C14B4.2 C14B4.2 Putative ortholog of C. elegans Y116F11.N gene product C14B9.2 C14B9.2 Protein with high similarity to protein disulfide isomerase related protein (rat Erp70), which catalyzes the formation and isomerization of disulfide bonds in protein folding, member of the thioredoxin family erp72; This gene encodes a protein predicted by Eisenberg and coworkers, with 52% accuracy, to be mitochondrial. C14B9.3 C14B9.3 Protein of unknown function, has high similarity to uncharacterized C. elegans F36H9.5 C14B9.6 C14B9.6 Protein containing two Myb-like DNA-binding domains, has a region of weak similarity to a region of nuclear receptor corepressor 2 (human NCOR2), which is a nuclear receptor and transcription factor corepressor and is associated with myeloid leukemia gei-8 encodes a novel protein highly similar to C. briggsae BP:CBP04038 that contains a glutamine/asparagine (Q/N)-rich ('prion') domain (by the algorithm of Michelitsch and Weissman) and two myb-like DNA-binding domains; interacts with GEX-3 in yeast two-hybrid assays. C14B9.7 C14B9.7 Member of the ribosomal protein L21 protein family Ribosomal protein L21; rpl-21 encodes a large ribosomal subunit L21 protein; by homology, RPL-21 is predicted to function in protein biosynthesis; in C. elegans, RPL-21 activity is required for embryonic and germline development. C14B9.8 C14B9.8 Protein with moderate similarity to liver phosphorylase kinase alpha 2 (human PHKA2), which is the alpha subunit of liver phosphorylase kinase and a regulatory enzyme involved in glycogen breakdown Phosphorylase kinase; C14B9.8 is orthologous to the human gene PHOSPHORYLASE KINASE, LIVER, ALPHA-2 SUBUNIT (PHKA2; OMIM:306000), which when mutated leads to liver glycogenosis. C14C10.1 C14C10.1 Member of the mitochondrial carrier protein family of membrane transporters, has moderate similarity to S. cerevisiae Mir1p, which is a phosphate transporter of the mitochondrial carrier (MCF) family mitochondrial carrier protein C14C10.2 C14C10.2 Protein of unknown function, has moderate similarity to C. elegans C56A3.2 Transthyretin-like family C14C10.3 C14C10.3 Protein of unknown function C14C10.4 C14C10.4 Protein of unknown function C14C10.5 C14C10.5 Protein of unknown function, has low similarity to uncharacterized human KIAA0077 Human mRNA (KIAA0077) product like C14C10.6 C14C10.6 Protein of unknown function C14C10.7 C14C10.7 Protein with strong similarity to C. elegans C56A3.2 gene product C14C11.1 C14C11.1 Protein of unknown function, has very strong similarity to uncharacterized C. elegans ZC317.6 C14C11.2 C14C11.2 Protein of unknown function, has very strong similarity to uncharacterized C. elegans ZC317.7 C14C11.3 C14C11.3 Protein of unknown function, has low similarity to uncharacterized C. elegans Y70D2A.2 C14C11.4 C14C11.4 Protein of unknown function, has low similarity to uncharacterized C. elegans H20E11.1 C14C11.5 C14C11.5 Protein of unknown function, has high similarity to uncharacterized C. elegans W05B10.5 7TM chemoreceptor, srx family C14C11.6 mut-14;C14C11.6 Member of the RNA helicase, DEAD-box protein family involved in RNA interference and gene silencing by antisense RNAs helicase; mut-14 mutants exhibit germline transposon activation, a deficient response to RNAi, resistance to co-suppression, and transgene desilencing. C14C11.7 C14C11.7 Protein of unknown function C14C11.8 C14C11.8 Protein containing 18 uncharacterized DUF139 cysteine repeat domains, has low similarity to uncharacterized C. elegans F07H5.8 The protein product of this gene is predicted to contain a glutamine/asparagine (Q/N)-rich ('prion') domain, by the algorithm of Michelitsch and Weissman (as of the WS77 release of WormBase, i.e., in wormpep77). C14C6.1 C14C6.1 Protein of unknown function, has high similarity to uncharacterized C. elegans F07G11.8 7TM chemoreceptor, srx family C14C6.10 C14C6.10 Member of the 7-transmembrane chemoreceptor family of G protein-coupled receptors (GPCR), has high similarity to uncharacterized C. elegans SRI-74 7TM chemoreceptor, sri family C14C6.12 C14C6.12 Protein containing a DUF19 domain of unknown function, which contain twelve conserved cysteines, has low similarity to uncharacterized C. elegans C03G6.5 C14C6.13 C14C6.13 Protein of unknown function C14C6.2 C14C6.2 Protein of unknown function, has high similarity to uncharacterized C. elegans C14C6.5 C14C6.3 C14C6.3 Member of the glycosyl transferase family 11, which hydrolyze the glycosidic bond between two or more carbohydrates, has high similarity to uncharacterized C. elegans K06H6.6 C14C6.4 C14C6.4 Protein containing a nuclear hormone receptor ligand binding domain and a nuclear hormone receptor C-4 type zinc finger domain, has weak similarity to C. elegans NHR-80, which is required for embryogenesis zinc finger protein C14C6.5 C14C6.5 Protein of unknown function, has high similarity to uncharacterized C. elegans C14C6.2 C14C6.6 C14C6.6 Protein containing a DUF138 domain of unknown function, has high similarity to uncharacterized C. elegans ZK488.5 C14C6.7 C14C6.7 Protein containing a DUF138 domain of unknown function, has high similarity to uncharacterized C. elegans ZK488.5 C14C6.8 C14C6.8 Protein containing a DUF138 domain of unknown function, has strong similarity to uncharacterized C. elegans K06H6.4 C14C6.9 C14C6.9 Protein of unknown function, has high similarity to an uncharacterized C. elegans F07G11.8 7TM chemoreceptor, srx family C14E2.1 C14E2.1 Protein of unknown function C14E2.2 C14E2.2 Protein containing an aminotransferase class I and II domain, has high similarity to a region of soluble glutamate-oxaloacetate transaminase (cytosolic aspartate aminotransferase, human GOT1), which acts in the transfer of the amino group from aspartate aspartate aminotransferase C14E2.3 C14E2.3 Protein of unknown function C14E2.4 C14E2.4 Has similarity over the middle region to human proline 4-hydroxylase alpha subunits P4HA2 and P4HA1; has strong similarity to C. elegans Y43F8B.4 C14E2.5 C14E2.5 Protein of unknown function C14E2.6 C14E2.6 Member of the lipase class 3 family, which are a subset of lipolytic enzymes that hydrolyze ester linkages of triglycerides triacylgycerol lipase C14F11.1 C14F11.1 Protein with high similarity to mitochondrial aspartate aminotransferase (glutamic oxaloacetic transaminase, plasma membrane fatty acid binding protein, human GOT2), contains an aminotransferase class I and II domain Aspartate aminotransferase C14F11.2 C14F11.2 Protein containing six leucine rich repeats, which mediate protein-protein interactions, has a region of low similarity to a region of C. elegans SOC-2, which is a positive regulator of the let-60 ras pathway and vulval induction C14F11.3 gur-2;C14F11.3 Member of the seven-transmembrane receptor odorant receptor family, which function in olfaction, has moderate similarity to uncharacterized C. elegans GUR-3 chemoreceptor C14F11.4 C14F11.4 Protein of unknown function C14F11.5 hsp43;C14F11.5 Member of the Hsp20 or alpha crystallin family, has a region of low similarity to heat shock 27kD protein 1 (human HSPB1), which plays a role in thermotolerance and functions as a chaperone and negative regulator of apoptosis heat shock protein; hsp-43 encodes a member of the hsp20 family. C14F11.6 C14F11.6 Member of the dTDP-4-dehydrorhamnose 3,5-epimerase family, which catalyze isomerisation in lipopolysaccharide biosynthesis DTDP-4-dehydrorhamnose 3,5-epimerase (RFBC gene) C14F11.7 C14F11.7 Protein of unknown function C14F5.1 bcl-2;nip3;ceBNIP3;C14F5.1 Similar to human BNIP3; induces cell death almost as efficiently as human BNIP3 in 293T cells C14F5.2 zig-3;C14F5.2 Putative member of Immunoglobulin superfamily IG-like C2-type domain C14F5.3 C14F5.3 Member of the troponin family, which regulate calcium-induced muscle contraction troponin T; tnt-3 is orthologous to the human gene TROPONIN T (TNNT2; OMIM:191045), which when mutated leads to disease. C14F5.4 C14F5.4 Member of the mitochondrial tricarboxylate carrier (MTC) protein family C14F5.5 sem-5;C14F5.5 Cell signaling protein with SH2 and SH3 domains that is required for vulval induction and sex myoblast migration; putative ortholog of murine GRB2 or growth factor receptor-bound protein 2 C. elegans sem-5; sem-5 encodes a Src homology (SH) domain 2 and 3-containing protein, orthologous to human GRB2 (OMIM:108355), that functions in multiple signaling pathways during development; these pathways include those regulating sex myoblast migration, vulval induction, fluid balance, viability, and formation of the male tail; SEM-5 acts downstream of the LET-23 epidermal growth factor receptor to negatively regulate RAS-MAP-, as well as IP-3-, mediated signal transduction. C14H10.1 C14H10.1 Member of the ZIP zinc transporter family, which may be metal transporters Yeast YIL023C-like protein C14H10.2 C14H10.2 Putative coiled-coil protein, has similarity to myosins and human Golgi autoantigens C14H10.3 C14H10.3 Protein of unknown function, has low similarity to uncharacterized mouse Kiaa0251-hp terminase domain C14H10.4 C14H10.4 Member of the 7-transmembrane chemoreceptor family of G protein-coupled receptors (GPCR), has low similarity to C. elegans ODR-10, which is involved in odorant response C15A11.1 C15A11.1 Protein containing a collagen triple helix repeat, has moderate similarity to a region of alpha 2 subunit of type XI collagen (human COL11A2), which is associated with some forms of Stickler syndrome and Chondrodystrophy with sensorineural deafness collagen; col-35 encodes a collagen that is individually dispensable for viability and gross morphology in mass RNAi screens; the amino- and carboxyl-terminal cysteine-rich regions of COL-35 are most closely related to those of COL-8, COL-19, and COL-39. C15A11.2 C15A11.2 Protein of unknown function, has moderate similarity to uncharacterized C. elegans Y67A6A.1 C15A11.3 C15A11.3 Protein containing a CUB domain, which occurs extracellularly often in developmentally regulated proteins CUB domain C15A11.4 C15A11.4 Protein of unknown function, has high similarity to uncharacterized C. elegans C15A11.7 amine oxidase C15A11.5 col-7;C15A11.5 Collagen collagen; col-7 encodes a member of the collagen superfamily containing collagen triple helix repeats (20 copies); expressed during the L2-to-dauer molt and the L4-to-adult molt. C15A11.6 C15A11.6;col-7 Protein containing three collagen triple helix repeats, which are found in some extracellular proteins, and a nematode cuticle collagen N-terminal domain, has moderate similarity to a region of C. elegans BLI-1 collagen C15A11.7 C15A11.7 Protein of unknown function, has high similarity to uncharacterized C. elegans C15A11.4 amine oxidase C15A7.1 C15A7.1 Protein containing two neurotransmitter-gated ion-channel ligand binding domains, has a region of weak similarity to a region of alpha 7 subunit of the neuronal nicotinic acetylcholine receptor (human CHRNA7), which is highly permeable to calcium acetylcholine receptor C15A7.2 C15A7.2 Protein of unknown function, has weak similarity to C. elegans T04F8.2 C15A7.3 C15A7.3 Protein of unknown function C15B12.1 C15B12.1 Protein with moderate similarity to peroxisomal sarcosine oxidase (mouse Pso), which is a peroxisomal flavoprotein that catalyzes the oxidation of L-pipecolic acid and sarcosine and is inhibited by N-bromosuccinimide sarcosine oxidase C15B12.2 C15B12.2 Protein of unknown function C15B12.3 C15B12.3 Protein of unknown function C15B12.4 C15B12.4 Protein with weak similarity to C. elegans H02F09.3 gene product C15B12.5 gar-1;C15B12.5 G protein-linked acetylcholine receptor with three alternatively spliced forms Muscarinic acetycholine receptor; gar-1 encodes a G-protein-linked acetylcholine receptor; though gar-1 is most closely related to muscarinic acetylcholine receptors (mAChR), it is pharmacologically distinct from them in its response to certain ligands; gar-1 gene transcripts are expressed at all developmental stages; the GAR-1-GFP fusion protein is expressed in some head neurons and in the PVM neuron; electrophysiological studies indicate that gar-1 couples to the inhibitory subunit of G proteins and not to Gs or to Go/Gq. C15B12.6 C15B12.6 Protein of unknown function C15B12.7 cdf-1;C15B12.7 Member of the cation efflux family, which may be membrane divalent cation transporters, has low similarity to zinc transporter 1 (rat Slc30a1), which lowers intracellular zinc by stimulating zinc efflux and reduces vulnerability to Zn2+ induced toxicity Cobalt uptake protein (S. cerevisiae); a cation diffusion facilitator protein, affects vulva development, genetically interacts with let-60/ras signaling pathway; and is expressed in the vulval muscles, the intestinal cells, and in the vulval precursor cells. C15B12.8 C15B12.8 Putative ortholog of C. elegans C15B12.1 gene product C15C6.1 C15C6.1 Protein of unknown function C15C6.2 C15C6.2 Protein of unknown function, has low similarity to uncharacterized C. elegans R09E10.6 C15C6.3 C15C6.3 Protein of unknown function C15C6.4 C15C6.4 Protein containing a UPF0086 domain of unknown function, has low similarity to a region of processing of precursor 4 homolog (human POP4), which is a subunit of tRNA processing enzyme ribonuclease P and ribosomal RNA processing enzyme ribonuclease MRP C15C7.1 C15C7.1 Protein of unknown function, contains a putative transmembrane domain, has weak similarity to human vesicle trafficking and docking proteins syntaxin 6 and SNAP25 (synaptosomal-associated protein, 25kD) (Hs.157144, Hs.84389) C15C7.2 C15C7.2 Protein containing a large coiled-coil domain and a putative golgi-localization (GRIP) domain klp-8 encodes an atypical kinesin-like motor protein with the motor domain in the N-terminus; the motor domain of KLP-8 exhibits poor homology to the globular motor domain of the kinesin heavy chain. C15C7.3 C15C7.3 Protein of unknown function C15C7.4 C15C7.4 Protein of unknown function C15C7.5 C15C7.5 Protein of unknown function C15C7.6 C15C7.6 Protein of unknown function C15C8.1 C15C8.1 Protein with moderate similarity to C. elegans K02E2.1 gene product C15C8.2 C15C8.2 Protein containing two PAS (Per, Arnt, Sim) domains, which may participate in sensory transduction, has weak similarity to a region of mouse Hif1a, which is a basic helix-loop-helix transcription factor Human ARNT-interacting protein like; cky-1 encodes a member of the basic-helix-loop-helix-PAS (bHLH-PAS) protein family; it is likely that CKY-1 together with AHA-1, another bHLH-PAS protein, has a role in pharyngeal function; CKY-1 is expressed in most non-neuronal pharyngeal cells. C15C8.3 C15C8.3 Member of the aspartyl (acid) protease family, has moderate similarity to C. elegans ASP-6, which is an aspartyl protease involved in protein degradation cathepsin-like protease C15C8.4 C15C8.4 Protein of unknown function Human alpha-2-macroglobulin receptor-associated protein like C15C8.5 C15C8.5 Protein of unknown function, has low similarity to uncharacterized C. elegans F44D12.2 C15C8.6 C15C8.6 Protein of unknown function C15C8.7 C15C8.7 Member of the G protein alpha subunit family C15F1.1 C15F1.1 Protein with strong similarity to C. elegans C28H8.5 C15F1.2 C15F1.2 Protein of unknown function C15F1.3 tra-2;C15F1.3 Transmembrane protein that promotes female development in animals that have two X chromosomes sex-determination protein; The tra-2 gene encodes a transmembrane receptor that functions in the sex determination pathway to specify hermaphrodite development in XX animals; tra-2 encodes two proteins: TRA-2A, the major protein expressed at all developmental stages, and TRA-2B, a form specific to the hermaphrodite germ line; in hermaphrodites, direct interaction between the TRA-2A intracellular domain inhibits FEM-3 masculinizing activity, whereas in males, TRA-2A is negatively regulated by HER-1, allowing the FEM proteins to specify male development. | The tra-2 gene encodes a transmembrane receptor that functions in the sex determination pathway to specify female fates in hermaphroditic XX animals; tra-2 encodes two proteins: TRA-2A, the major protein expressed at all developmental stages, and TRA-2B, a form specific to the hermaphrodite germ line; in hermaphrodites, direct interaction between the TRA-2A intracellular domain inhibits FEM-3 masculinizing activity, whereas in males, TRA-2A is negatively regulated by HER-1, allowing the FEM proteins to specify male development. C15F1.5 C15F1.5 Protein with weak similarity to C. elegans C16A3.7 (Protein with similarity to transcription factors, possible ortholog of S. cerevisiae Fap1p) zinc finger protein C15F1.6 C15F1.6 Protein with strong similarity to D. melanogaster CG10849 (CG10849 gene product) a protein similar to synaptic glycoprotein SC2 from mammals. C15F1.8 C15F1.8 Protein of unknown function C15F1.B sod-1;C15F1.7;C15F1.B Member of the superoxide dismutase, Cu/Zn protein family with strong similarity to human SOD1; appears to control an important determinant of aging in C. elegans C15F1.E ppp-1;C15F1.4;C15F1.E Protein containing a putative NTP transferase (nucleotidyl transferase) domain, has weak similarity to S. cerevisiae Psa1p (mannose-1-phosphate guanyltransferase; GDP-mannose pyrophosphorylase) C15H11.1 C15H11.1 Protein containing a major sperm protein (MSP) domain, which are involved in sperm motility, has weak similarity to uncharacterized C. elegans ZK354.7 C15H11.2 C15H11.2 Member of the rhodopsin family of G protein-coupled receptors (GPCR), has weak similarity to arginine vasopressin receptor 1B (mouse Avpr1b), which acts through multiple second messengers and induces release of ACTH from the pituitary G-protein coupled receptor C15H11.4 C15H11.4 Protein contains a putative short chain dehydrogenase domain, has strong similarity to C. elegans E04F6.7 protein dehydrogenase; dhs-22 encodes a short-chain dehydrogenase predicted to be mitochondrial. C15H11.5 C15H11.5 Protein containing a SET domain, which are involved in protein-protein interactions C15H11.7 pas-1;C15H11.7 Putative alpha-type subunit of 20S proteasome particle proteasome component (A-type); pas-1 encodes a type 6 alpha subunit of the 26S proteasome's 20S protease core particle (CP); PAS-1 is required for embryonic development and by homology, is predicted to comprise the outer rings of the proteasome and to play a role in selective degradation of ubiquitinated proteins during development; in vitro, PAS-1 interacts with VET-1, a coiled-coil domain-containing protein expressed in the early embryo and ATN-1, an alpha-actinin, in addition to other members of the proteasome. C15H11.8 C15H11.8 Member of the S-II (TFIIS) transcription factor family, has moderate similarity to zinc ribbon domain-containing 1 (human ZNRD1), which is a zinc-binding protein that may be involved in transcription or nucleic acid metabolism DNA-directed RNA polymerase I like C15H11.9 C15H11.9 Protein of unknown function, has a region of moderate similarity to S. cerevisiae Rrs1p, which is a regulator of ribosome synthesis Human HA0609 protein like C15H11.D C15H11.6;C15H11.d Protein of unknown function, has high similarity to a region of C. elegans C15H11.3, which is a nucleocytoplasmic transporter involved in embryogenesis and morphogenesis C15H11.E C15H11.3;C15H11.e Putative paralog of C. elegans C15H11.6, has similarity to S. cerevisiae RNA-binding protein Mex67p C15H7.3 C15H7.3 Member of the protein-tyrosine phosphatase family, which are involved in control of cell growth, proliferation, differentiation and transformation, has high similarity to uncharacterized C. elegans W01B6.6 Protein tyrosine phosphatase (non-receptor class) C15H7.4 C15H7.4 Protein of unknown function, has high similarity to uncharacterized C. elegans C10C6.3 C15H9.1 C15H9.1 Putative nicotinamide nucleotide transhydrogenase NAD(P) transhydrogenase, mitochondrial; nnt-1 encodes a proton-pumping nicotinamide nucleotide transhydrogenase predicted to be mitochondrial. C15H9.10 C15H9.10 Protein of unknown function C15H9.11 C15H9.11 Protein of unknown function C15H9.2 C15H9.2 Protein containing a BTB (BR-C, ttk and babor) or POZ (Pox virus and zinc finger) domain, which are found in some DNA and actin binding proteins and may mediate protein-protein interactions C15H9.3 C15H9.3 Member of the rhodopsin family of G protein-coupled receptors (GPCR) C15H9.4 C15H9.4 Protein of unknown function that has a region of moderate similarity to H. sapiens KIAA0779 C15H9.5 C15H9.5 Protein of unknown function, has low similarity to uncharacterized human GPR108 C15H9.6 hsp-3;C15H9.6 Heat shock cognate hsp70C heat shock protein; hsp-3 encodes a heat shock response 70 (hsp70) protein orthologous to human glucose regulated protein 78 (grp78/BiP, OMIM:138120); HSP-3 likely functions as a molecular chaperone, and is expressed constitutively (expression is not heat inducible) throughout development with greatest abundance during the L1 larval stage; HSP-3 contains a long hydrophobic amino terminus and a carboxyl terminal KDEL sequence suggesting that it may be retained in the endoplasmic reticulum. C15H9.7 C15H9.7;XG726 Protein with high similarity to kynureninase (L-kynurenine hydrolase, rat Kynu), which is a pyridoxal phosphate dependent enzyme that cleaves L-kynurenine and L-3-hydroxykynurenine to anthranilic and 3-hydroxyanthranilic acids kynureninase C15H9.8 C15H9.8 Protein of unknown function, has low similarity to a region of peroxisomal biogenesis factor 3 (peroxin 3, rat Pex3), which is an integral peroxisomal membrane protein required for peroxisome biogenesis prx-3 is orthologous to the human gene PEROXISOMAL BIOGENESIS FACTOR 3 (PEX3; OMIM:603164), which when mutated leads to Zellweger syndrome of complementation group G. C15H9.9 C15H9.9 Protein of unknown function, has weak similarity to C. elegans K11H12.7 C16A11.1 gpa-11;C16A11.1 Member of the G protein alpha subunit family guanine nucleotide-binding protein; gpa-11 encodes a member of the G protein alpha subunit family of heterotrimeric GTPases; it is expressed in ADL and ASH amphid neurons. C16A11.2 C16A11.2 Protein of unknown function, has weak similarity to uncharacterized C. elegans C31E10.6 C16A11.3 C16A11.3 Protein containing a two protein kinase domains, has a region of low similarity to a region of CDC-like kinase 3 (rat Clk3), which is a protein kinase that is predominantly expressed in testis protein kinase C16A11.4 C16A11.4 Protein containing a PHD-finger, which may be involved in chromatin-mediated transcriptional regulation, has moderate similarity to uncharacterized C. elegans Y14H12B_90.A C16A11.5 C16A11.5 Protein of unknown function, has weak similarity to uncharacterized C. elegans F46F2.1 C16A11.6 C16A11.6 Protein containing an F-box domain, which serve as a link between a target protein and a ubiquitin-conjugating enzyme C16A11.7 C16A11.7 Protein of unknown function, has high similarity to uncharacterized C. elegans F32B6.4 C16A11.8 C16A11.8 Protein of unknown function, has low similarity to uncharacterized C. elegans R13F6.8 C16A3.1 C16A3.1 Protein containing two helicase conserved C-terminal domains and two SNF2 related N-terminal domains, has moderate similarity to a region of mouse Smarcal1, which is a single-stranded DNA-dependent ATPase helicase C16A3.10 C16A3.10 Protein with high similarity to ornithine aminotransferase (L ornithine:2 oxoacid delta aminotransferase, human OAT), which has a role in retinal degeneration, member of the aminotransferase class III pyridoxalphosphate-dependent enzyme family ornithine aminotransferse precursor; The C16A3.10 gene encodes a homolog of the human gene OAT (OMIM:258870), which when mutated leads to ornithinemia and gyrate atrophy. C16A3.2 C16A3.2 Protein containing a dual specificity phosphatase catalytic domain, has low similarity to human DUSP3, which is a dual specificity phosphatase that dephosphorylates phosphotyrosine and phosphoserine residues to inactivate MAPK protein-tyrosine phosphatase C16A3.3 C16A3.3 Protein containing three S1 RNA binding domains, has weak similarity to S. cerevisiae Rrp5p, which is a protein required for processing of pre-rRNA to 18S and 5.8S rRNA C16A3.4 C16A3.4 Protein containing three C2H2 type zinc finger domains, which bind nucleic acids, has low similarity to uncharacterized human MGC17552 C16A3.5 C16A3.5 Protein of unknown function, has low similarity to uncharacterized NADH dehydrogenase ubiquinone 1 beta subcomplex 9 (22 kDa) (human NDUFB9), which is a putative subunit of the NADH-ubiquinone oxidoreductase multiprotein complex that transports electrons NADH-ubiquinone oxidoreductase B22 C16A3.6 C16A3.6 Protein with moderate similarity to S. cerevisiae Mak16p, which is a nuclear protein that is required for propagation of M1 double-stranded RNA (dsRNA) virus C16A3.7 C16A3.7 Protein containing nine zinc finger domains and an R3H domain, which may bind ssDNA, has moderate similarity to nuclear transcription factor X-box binding 1 (human NFX1), which is a transcription repressor that may regulate inflammatory response duration human NFX1; D. melanogaster shuttle craft protein; C16A3.7 encodes a protein with multiple zinc-finger domains, an R3H domain, and a glutamine/asparagine-rich domain. C16A3.8 C16A3.8 Protein of unknown function, has weak similarity to a region of S. cerevisiae Rlr1p, which is involved in transcription and transcription-associated recombination and has pleiotropic regulatory properties C16A3.9 rps-13;C16A3.9 Protein with high similarity to ribosomal protein S13 (S. cerevisiae Rps13p), which is a structural ribosomal protein, member of the ribosomal S15 family, which are part of the small ribosomal subunit 40S ribosomal protein S13; rps-13 encodes a small ribosomal subunit S13 protein; by homology, RPS-13 is predicted to function in protein biosynthesis; in C. elegans, RPS-13 activity is required for embryonic and germline development. C16B8.1 lin-18;C16B8.1;Ceryk Putative receptor tyrosine kinase; may play a role in establishing cell polarity; similar to human fibroblast growth factor receptor protein kinase and D. melanogaster DRL (derailed) protein kinase protein tyrosine kinase; lin-18 encodes a predicted receptor tyrosine kinase that is a member of the Ryk/Derailed family of tyrosine kinase-related receptors (OMIM:600524, mutations in humans are associated with cleft palate); in C. elegans, LIN-18 is required for establishing the polarity of the secondary vulval cell lineage produced by the P7.p hypodermal blast cell; LIN-18 may be a receptor for Wnt-like signaling molecules, and in vulval development appears to function independently of, but in parallel with, LIN-17, a Frizzled-like Wnt receptor, also required for proper orientation of the P7.p lineage. | lin-18 encodes a predicted receptor tyrosine kinase that is a member of the Ryk/Derailed family of tyrosine kinase-related receptors (OMIM:600524, mutations in humans are associated with cleft palate); in C. elegans, LIN-18 is required for establishing the polarity of the secondary vulval cell lineage produced by the P7. C16B8.2 C16B8.2 Protein of unknown function C16B8.3 C16B8.3 Protein of unknown function C16B8.4 C16B8.4 Protein of unknown function C16C10.1 C16C10.1 Member of the mitochondrial carrier protein family of membrane transporters, has low similarity to S. cerevisiae Sfc1p, which is the mitochondrial membrane succinate-fumarate transporter carrier protein C16C10.10 C16C10.10 Member of the glyoxalase, bleomycin resistance or dioxygenase superfamily, which are involved in the glyoxal pathway Glyoxalase C16C10.11 C16C10.11 Protein of unknown function, high similarity to uncharacterized human LOC51142 C16C10.12 C16C10.12 Member of the ABC transporter family, which are involved in translocation across biological membranes, has low similarity to ATP-binding cassette subfamily G member 2 (mouse Abcg2), which is a transporter involved in multidrug resistance ATP binding transport protein (White protein) C16C10.2 C16C10.2 Protein of unknown function, has moderate similarity to uncharacterized human LOC51118 C16C10.3 C16C10.3 Piwi-related protein with similarity over the C-terminal region to human and D. melanogaster PIWI proteins and C. elegans PRG-1 and PRG-2, all of which are involved in germ-line proliferation C16C10.4 C16C10.4 Protein with high similarity to sin3 associated protein 18 kD (human SAP18), which is a component of the Sin3-histone deacetylase corepressor complex that functions as a transcription co-repressor C16C10.5 C16C10.5 Protein containing a C3HC4 type RING zinc finger, which may mediate protein-protein interactions Glutaredoxin, Zinc finger, C3HC4 type (RING finger) C16C10.6 C16C10.6 Protein with weak similarity to C. elegans unc-89, a muscle cell protein of the immunoglobulin-like protein family that is required for coordinated locomotion C16C10.7 C16C10.7 Protein containing a C3HC4 type RING zinc finger, which may mediate protein-protein interactions, has moderate similarity to uncharacterized RING finger protein 5 (mouse Rnf5) Zinc finger, C3HC4 type (RING finger); This gene encodes a homolog of mammalian RNF5, a C3HC4 (RING-finger) zinc-finger protein. C16C10.8 C16C10.8 Protein with similarity to mouse LYAR protein, a cell growth regulating nucleolar protein cell growth regulating protein C16C10.9 C16C10.9 Protein of unknown function C16C2.1 ceh-5;C16C2.1 Protein containing a homeobox (homeodomain) domain, has a region of high similarity to a region of ventral anterior homeobox containing gene 1 (mouse Vax1), which is required for the development of the visual system and is involved in axon guidance Homeobox domain; ceh-5 encodes a homeodomain protein, similar to the human VENTRAL ANTERIOR HOMEO BOX 2 gene (VAX2; OMIM:604295); CEH-5 is dispensable for viability and gross morphology. C16C2.2 eat-16;C16C2.2 Putative regulator of G protein signalling regulator of G-protein signalling; The eat-16 gene encodes an RGS protein that affects movement, pharyngeal pumping, egg laying, and synaptic transmission; it genetically interacts with the egl-30 and goa-1 signaling pathways, and is expressed in excitable cells and in the spermatheca. C16C2.3 C16C2.3 Putative phosphatidylinositol (4,5) bisphosphate 5-phosphatase inositol-1,4,5-triphosphate 5-phosphatase; The C16C2.3 gene encodes an inositol-1,4,5-triphosphate 5-phosphatase homolog that is homologous to human OCRL. C16C2.4 C16C2.4 Protein of unknown function, has low similarity to uncharacterized human SYAP1 C16C4.1 C16C4.1 Protein of unknown function, has weak similarity to C. elegans C46F9.4 C16C4.10 C16C4.10 Protein containing two meprin and TRAF homology (MATH) domains, has high similarity to uncharacterized C. elegans C16C4.5 C16C4.11 C16C4.11 Protein containing two meprin and TRAF homology (MATH) domains, has high similarity to uncharacterized C. elegans C16C4.10 C16C4.12 C16C4.12 Protein containing two meprin and TRAF homology (MATH) domains, has high similarity to uncharacterized C. elegans C16C4.5 C16C4.13 C16C4.13 Protein containing three meprin and TRAF homology (MATH) domains, has high similarity to uncharacterized C. elegans ZK250.7 C16C4.14 C16C4.14 Protein containing two meprin and TRAF homology (MATH) domains, has moderate similarity to uncharacterized C. elegans C46F9.1 C16C4.15 C16C4.15 Protein containing two meprin and TRAF homology (MATH) domains, has high similarity to uncharacterized C. elegans C16C4.4 C16C4.16 C16C4.16 Protein containing a meprin and TRAF homology (MATH) domain, has moderate similarity to uncharacterized C. elegans C16C4.3 C16C4.2 C16C4.2 Protein containing a meprin and TRAF homology (MATH) domain, has weak similarity to uncharacterized C. elegans F40B1.1 C16C4.3 C16C4.3 Protein containing two meprin and TRAF homology (MATH) domains, has high similarity to uncharacterized C. elegans C16C4.8 C16C4.4 C16C4.4 Protein containing two meprin and TRAF homology (MATH) domains, has high similarity to uncharacterized C. elegans C16C4.15 C16C4.5 C16C4.5 Protein containing two meprin and TRAF homology (MATH) domains, has high similarity to uncharacterized C. elegans C16C4.10 C16C4.6 C16C4.6 Protein containing an F-box domain, which serve as a link between a target protein and a ubiquitin-conjugating enzyme This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins; its encoded protein also contains a Pfam-B45 motif of presently unknown function. C16C4.7 C16C4.7 Protein of unknown function C16C4.8 C16C4.8 Protein containing two meprin and TRAF homology (MATH) domains, has high similarity to uncharacterized C. elegans C16C4.3 C16C4.9 C16C4.9 Protein containing three meprin and TRAF homology (MATH) domains, has high similarity to uncharacterized C. elegans C16C4.10 C16C8.10 C16C8.10 Protein with moderate similarity to C. elegans Y49F6B.H gene product C16C8.11 C16C8.11 Member of the ubiquitin family, has low similarity to uncharacterized C. elegans C16C8.4 C16C8.12 C16C8.12 Member of the ubiquitin family, has moderate similarity to uncharacterized C. elegans C16C8.14 C16C8.13 C16C8.13 Member of the ubiquitin family, has high similarity to uncharacterized C. elegans C16C8.14 C16C8.14 C16C8.14 Member of the ubiquitin family, has high similarity to uncharacterized C. elegans C16C8.13 C16C8.16 C16C8.16 Member of the ubiquitin family C16C8.17 C16C8.17 Protein of unknown function, has weak similarity to C. elegans F14H3.7 C16C8.18 C16C8.18 Protein with moderate similarity to C. elegans R13H9.1 gene product C16C8.19 C16C8.19 Protein of unknown function C16C8.2 C16C8.2 Member of the animal heme peroxidase family, has low similarity to eosinophil peroxidase (mouse Epx), which plays a role in the production of reactive oxidants that may have cytotoxic effects during the pathogen defense response and inflammation peroxidase precursor C16C8.4 C16C8.4 Member of the ubiquitin family, has low similarity to uncharacterized C. elegans C16C8.11 C16C8.5 C16C8.5 Member of the ubiquitin family C16C8.6 C16C8.6 Member of the transposase family, which are required for excising and inserting mobile genetic elements, has very strong similarity to uncharacterized C. elegans Y73B3A.19 transposase C16C8.7 C16C8.7 Protein of unknown function C16C8.8 C16C8.8 Protein of unknown function, has high similarity to uncharacterized C. elegans C16C8.9 C16C8.9 C16C8.9 Protein of unknown function, has high similarity to uncharacterized C. elegans C16C8.8 C16D2.1 C16D2.1 Protein of unknown function C16D6.1 C16D6.1 Protein of unknown function C16D6.2 C16D6.2 Member of the rhodopsin family of G protein-coupled receptors (GPCR), has low similarity to C. elegans NPR-1 7 transmembrane receptor (rhodopsin family) C16D6.3 C16D6.3 Protein of unknown function C16D9.1 C16D9.1 Protein containing two PAN domains, which may mediate protein-protein or protein-carbohydrate interactions C16D9.2 C16D9.2 Protein containing three fibronectin type III domains, which are involved in cell surface binding, and two protein kinase domains, has weak similarity to mouse Ros1, which is a proto-oncogene and protein tyrosine kinase with transformation potential tyrosine-protein kinase; rol-3 was identified in screens for recessive mutations that affect body morphology; strong loss-of-function mutations in rol-3 result in early-to-mid larval lethality, while weaker mutations result in animals that are left-handed rollers at the adult stage only; lethal rol-3 mutations are suppressed by mutations in srl-1 and srl-2; the molecular identity of rol-3 is not yet known. C16D9.3 C16D9.3 Protein containing a DUF235 domain of unknown function, has high similarity to uncharacterized C. elegans C17A2.6 C16D9.4 C16D9.4 Protein containing a DUF235 domain of unknown function, has high similarity to uncharacterized C. elegans C16D9.5 C16D9.5 C16D9.5 Protein containing a DUF235 domain of unknown function, has high similarity to uncharacterized C. elegans F22E5.1 C16D9.6 C16D9.6 Putative ortholog of C. elegans T22B11.2 gene product C16D9.7 C16D9.7 Protein containing a DUF32 domain of unknown function, has high similarity to uncharacterized C. elegans C24B9.2 7TM chemoreceptor, srt family C16D9.8 C16D9.8 Protein of unknown function C16D9.9 C16D9.9 Protein of unknown function C16E9.1 C16E9.1 Protein containing two von Willebrand factor (vWF) type A domains, has weak similarity to matrilin 1 (cartilage matrix protein, mouse Matn1), which is a putative component of the extracellular matrix that forms homodimers and binds collagen and aggrecan C16E9.2 C16E9.2 Protein of unknown function C16E9.4 opu-1;pcr55;C16E9.4 Protein with high similarity to C. elegans UNC-7, which is required in motor neurons for coordinated locomotion, member of the integral membrane innexin family, which are involved in the formation of gap junctions inx-1 encodes a predicted member of the innexin family; expressed in 4-6 anterior neurons. C16E9.5 C16E9.5 Protein of unknown function C16E9.6 C16E9.6 Protein of unknown function C16H3.1 C16H3.1 Protein with low similarity to Kv4 channel-interacting protein 2 (mouse Kcnip2), which interacts with alpha subunits of Kv4 potassium channels to regulate the Kv4.2-mediated transient outward potassium current and is associated with cardiac arrythmias calcium binding proteins C16H3.2 lec-9;C16H3.2 Member of the galectin family, which are lectins that bind beta galactosides, has low similarity to a region of galactoside-binding soluble 9 (galectin 9, human LGALS9), which is a lectin that is involved in cell adhesion and chemoattraction sugar-binding protein; lec-9 encodes a predicted lectin that affects embryonic viability. C16H3.3 C16H3.3 Protein with strong similarity to C. elegans C16H3.4 gene product C17A2.1 C17A2.1 Protein containing a nuclear hormone receptor C4-type zinc finger domain, which bind DNA and may be involved in transcription regulation, has strong similarity to uncharacterized C. elegans C49D10.9 zinc finger protein C17A2.2 C17A2.2 Protein containing a DUF138 domain of unknown function, has high similarity to uncharacterized C. elegans T05B11.4 C17A2.3 C17A2.3 Protein of unknown function, has high similarity to uncharacterized C. elegans F56H6.1 C17A2.4 C17A2.4 Member of the glycosyl transferase family 11, which hydrolyze the glycosidic bond between two or more carbohydrates, has high similarity to uncharacterized C. elegans Y5H2B.1 C17A2.5 C17A2.5 Protein containing three DUF33 domains of unknown function, has high similarity to uncharacterized C. elegans F14B6.5 C17A2.6 C17A2.6 Protein containing a DUF235 domain of unknown function, has high similarity to uncharacterized C. elegans C16D9.3 C17A2.7 C17A2.7 Member of the domain of unknown function DUF13 family, has high similarity to uncharacterized C. elegans R09H10.2 C17A2.8 nhr-72;C17A2.8 Member of the zinc finger protein family, may be involved in epidermal fate specification zinc finger protein C17B7.1 C17B7.1 Member of the 7-transmembrane chemoreceptor family of G protein-coupled receptors (GPCR), has weak similarity to C. elegans STR-2, which is expressed in either the left or right AWC odorant neurons as a result of a stochastic process 7TM chemoreceptor, str family C17B7.10 C17B7.10 Member of the M13 peptidase family of zinc metalloproteases, has high similarity to uncharacterized C. elegans T28A11.20 C17B7.10 encodes a neprilysin; neprilysins are thermolysin-like zinc metallopeptidases, found on the outer surface of animal cells, that negatively regulate small signalling peptides (e.g., enkephalin, tachykinin, insulin, and natriuretic peptides) by cleaving them; C17B7.10 has no clear orthologs in other organisms. C17B7.11 C17B7.11 Protein containing an F-box domain, which serve as a link between a target protein and a ubiquitin-conjugating enzyme, and a DUF38 domain of unknown function, has low similarity to C. elegans FOG-2 This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins; this gene's encoded protein also contains an FTH/DUF38 motif, which may also mediate protein-protein interaction. C17B7.12 C17B7.12 Protein of unknown function, putative paralog of F35F10.5 C17B7.2 C17B7.2 Protein containing two DUF19 domains of unknown function, which contain twelve conserved cysteines, has high similarity to uncharacterized C. elegans T28A11.2 C17B7.3 C17B7.3 Protein containing a DUF19 domain of unknown function, which contain twelve conserved cysteines, has strong similarity to uncharacterized C. elegans T28A11.3 C17B7.4 C17B7.4 Protein containing a DUF19 domain of unknown function, which contain twelve conserved cysteines, has strong similarity to uncharacterized C. elegans T28A11.5 C17B7.5 C17B7.5 Protein of unknown function, has high similarity to uncharacterized C. elegans F35F10.10 C17B7.6 C17B7.6 Protein of unknown function, has high similarity to uncharacterized C. elegans T01C1.1 C17B7.7 C17B7.7 Putative ortholog of C. elegans F23A7.5 gene product C17B7.8 C17B7.8 Member of the M13 peptidase family of zinc metalloproteases, has strong similarity to uncharacterized C. elegans T28A11.17 C17B7.8 encodes a neprilysin; neprilysins are thermolysin-like zinc metallopeptidases, found on the outer surface of animal cells, that negatively regulate small signalling peptides (e.g., enkephalin, tachykinin, insulin, and natriuretic peptides) by cleaving them; C17B7.8 has no clear orthologs in other organisms. C17B7.9 C17B7.9 Protein containing a DUF19 domain of unknown function, which contain twelve conserved cysteines, has strong similarity to uncharacterized C. elegans T28A11.18 C17C3.1 C17C3.1 Member of the Acyl-CoA thioesterase family, which hydrolyze a range of acyl-CoA thioesters, has moderate similarity to peroxisomal acyl-CoA thioesterase 1 (human PTE1), which cleaves thioester bonds on medium chain acyl CoAs and binds HIV Nef protein C17C3.10 C17C3.10 Protein of unknown function, has strong similarity to uncharacterized C. elegans C17C3.7 C17C3.11 C17C3.11 Protein of unknown function, has high similarity to uncharacterized C. elegans K11C4.1 C17C3.12 C17C3.12 Protein with high similarity to human ACADSB, which is a short branched chain acyl-CoA dehydrogenase, contains two acyl-CoA dehydrogenase N-terminal domains, two acyl-CoA dehydrogenase middle domains and six acyl-CoA dehydrogenase C-terminal domains acyl-CoA dehydrogenase C17C3.13 C17C3.13 Protein of unknown function, has very strong similarity to uncharacterized C. elegans C17C3.2 C17C3.15 C17C3.15 Protein with moderate similarity to C. elegans H12I13.1 gene product C17C3.2 C17C3.2 Protein of unknown function, has very strong similarity to uncharacterized C. elegans C17C3.13 C17C3.3 C17C3.3 Member of the Acyl-CoA thioesterase family, which hydrolyze a range of acyl-CoA thioesters, has low similarity to a region of peroxisomal acyl-CoA thioesterase 1 (human PTE1), which cleaves medium chain acyl CoAs thioester bonds and binds HIV Nef protein C17C3.4 ins-11;Ceinsulin-3;C17C3.4 Insulin-like protein of the type-gamma subfamily ins-11 encodes an insulin-like peptide of the insulin superfamily of proteins (OMIM:176730, 147440); INS-11 is one of 38 insulin-like peptides in C. elegans and is expressed in the labial sensory neurons, the nerve ring, and other neurons; although the precise role of INS-11 in C. elegans development is not yet clear, loss of INS-11 function via RNA-mediated interference can result in animals that are smaller than wild type (Sma). C17C3.5 C17C3.5 Protein containing a DUF38 domain of unknown function C17C3.6 C17C3.6 Protein of unknown function, has similarity to members of an unnamed protein family including C. elegans M162.8 This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins. C17C3.7 C17C3.7 Protein of unknown function, has strong similarity to uncharacterized C. elegans C17C3.10 C17C3.8 C17C3.8 Protein containing one helix-loop-helix DNA-binding domain, which mediate protein dimerization, has low similarity to uncharacterized C. elegans C17C3.7 C17C3.9 C17C3.9 Protein of unknown function C17D12.1 C17D12.1 Protein containing two DHHC-type zinc finger (NEW1) domains, has a region of moderate similarity to a region of huntingtin interacting protein H (human HYPH), which is associated with Huntington disease C17D12.2 C17D12.2 Protein containing two RNA recognition motifs (RRM, RBD, or RNP), has moderate similarity to bruno-like 5 (human BRUNOL5), which is a pre-mRNA splicing factor involved in cell-specific alternative splicing RNA recognition motif. (aka RRM, RBD, or RNP domain) (2 domains); unc-75 encodes an RNA-binding protein with two N-terminal RNA recognition motifs (RRMs), a glutamine/asparagine-rich linker domain, and a third C-terminal RRM; UNC-75 is orthologous to mammalian CELF/BrunoL proteins that control pre-mRNA splicing; unc-75 is expressed in all neurons and in neurosecretory gland cells, and is required for normal modulation of GABA- and acetylcholine-mediated neurotransmission; UNC-75 protein is found with other RRM proteins in dynamic nuclear speckles, consistent with a role in alternative mRNA splicing; unc-75 mutations can be rescued in vivo by a human unc-75 transgene, but not by exc-7 or W02D3.11, indicating that UNC-75 acts on evolutionarily conserved but highly specific pre-mRNA substrates; both UNC-75 and EXC-7 are required in parallel for normal cholinergic neurotransmission. C17D12.3 C17D12.3 Protein of unknown function, has very strong similarity to uncharacterized C. elegans Y47H9A.1 C17D12.4 C17D12.4 Protein of unknown function C17D12.5 C17D12.5 Protein of unknown function C17D12.6 spe-9;C17D12.6 Transmembrane protein found in sperm and required for spermatogenesis EGF-like domain (2 domains); spe-9 encodes a predicted plasma membrane protein with a short intracellular domain and external EGF-like repeats most closely resembling those of the Delta, Serrate, APX-1, and LAG-2 signaling ligands; SPE-9 is required autonomously in sperm for fertilization, and by homology, likely mediates an adhesive or signaling event necessary for proper oocyte fertilization; spe-9 mRNA is detected solely in animals that are engaged in spermatogenesis; the receptor for SPE-9 is not yet known. C17D12.7 C17D12.7 Protein of unknown function C17E4.1 C17E4.1 Putative ortholog of C. elegans T09A12.1 gene product C17E4.10 C17E4.10 Protein of unknown function C17E4.2 C17E4.2 Putative coiled-coil protein, has similarity to S. cerevisiae Nuf1p, a component of the nucleoskeleton myosin heavy chain like C17E4.3 C17E4.3 Protein with weak similarity to C. elegans D2089.2 gene product C17E4.4 C17E4.4 Protein of unknown function C17E4.5 C17E4.5 Protein containing an RNA recognition motif (RRM, RBD, or RNP), has high similarity to a region of poly(A)-binding protein nuclear 1 (human PABPN1), which stimulates long poly(A) tail synthesis and is associated with oculopharyngeal muscular dystrophy RNA binding protein (RNP like); pab-3 is orthologous to human PABPN1 (OMIM:602279, mutated in oculopharyngeal muscular dystrophy). C17E4.6 C17E4.6 Protein of unknown function, has a region of low similarity to transcription factor-like 1 (mouse Tcfl1), which is a putative transcription factor YL-1 protein like C17E4.9 C17E4.9 Member of the Na+,K+ ATPase beta subunit family, which regulate the number of sodium pumps transported to the plasma membrane, has low similarity to beta 1 subunit of Na+/K+-ATPase (rat Atp1b1), which is involved in ion concentration homeostasis sodium/potassium transporting ATPase beta chain C17E7.1 C17E7.1 Protein containing a nuclear hormone receptor C4-type zinc finger domain, which bind DNA and may be involved in transcription regulation, has high similarity to a region of C. elegans NHR-58 zinc-finger protein C17E7.10 C17E7.10 Protein containing a DUF41 domain of unknown function, has moderate similarity to uncharacterized C. elegans F11A5.7 C17E7.11 C17E7.11 Member of the 7-transmembrane chemoreceptor family of G protein-coupled receptors (GPCR), has weak similarity to C. elegans ODR-10, which is a G protein-coupled receptor involved in odorant response 7TM chemoreceptor, str family C17E7.12 C17E7.12 Protein of unknown function C17E7.13 C17E7.13 Protein of unknown function C17E7.2 C17E7.2 Member of the 7-transmembrane chemoreceptor family of G protein-coupled receptors (GPCR), has high similarity to uncharacterized C. elegans R03H4.9 7TM chemoreceptor, srh family C17E7.3 C17E7.3 Member of the C. elegans Sre G protein-coupled chemoreceptor family, which are putative chemosensory receptors 7TM chemoreceptor, sre family C17E7.4 C17E7.4 Has strong similarity to C. elegans F08G2.7 gene product C17E7.5 C17E7.5 Protein containing nuclear hormone receptor ligand-binding and C4-type zinc finger domains, which bind DNA and may be involved in regulation of transcription, has moderate similarity to C. elegans NHR-51 nuclear hormone receptor C17E7.6 C17E7.6 Protein containing a nuclear hormone receptor ligand-binding domain and a nuclear hormone receptor C4-type zinc finger domain, which bind DNA and may be involved in regulation of transcription, has low similarity to C. elegans NHR-51 nuclear hormone receptor C17E7.7 C17E7.7 Protein containing a nuclear hormone receptor ligand-binding domain and a nuclear hormone receptor C4-type zinc finger domain, which bind DNA and may be involved in regulation of transcription, has low similarity to C. elegans NHR-51 nuclear hormone receptor C17E7.8 C17E7.8 Protein containing a nuclear hormone receptor ligand-binding domain and a nuclear hormone receptor C4-type zinc finger domain, which bind DNA and may be involved in regulation of transcription, has weak similarity to C. elegans NHR-51 nuclear hormone receptor C17F3.1 C17F3.1 Protein of unknown function C17F3.3 C17F3.3 Protein of unknown function, has high similarity to uncharacterized C. elegans ZK354.3 C17F4.1 C17F4.1 Protein with strong similarity to C. elegans T26E3.1 gene product C17F4.2 C17F4.2 Protein of unknown function, has weak similarity to C. elegans R11G1.2 C17F4.3 C17F4.3 Protein of unknown function, has strong similarity to uncharacterized C. elegans T23F6.2 C17F4.4 C17F4.4 Member of the 7-transmembrane chemoreceptor family of G protein-coupled receptors (GPCR), has high similarity to uncharacterized C. elegans Y94A7B.4 7TM chemoreceptor, srh family C17F4.5 C17F4.5 Protein containing an F-box domain, which serve as a link between a target protein and a ubiquitin-conjugating enzyme, has low similarity to uncharacterized C. elegans M02B7.1 This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins. C17F4.6 gcy-19;C17F4.6 Protein containing a receptor family ligand binding domain, a protein kinase domain, and an adenylate and guanylate cyclase catalytic domain, has low similarity to natriuretic peptide receptor B (rat Npr2) guanylate cyclase; gcy-19 encodes a predicted transmembrane guanylyl cyclase; as loss of gcy-19 activity via RNA-mediated interference does not result in any abnormalities, the precise role of GCY-19 in C. elegans development and/or behavior is not yet known; by sequence similarity, however, GCY-19 can be predicted to function in chemosensory signal transduction. C17F4.7 C17F4.7 Putative ortholog of C. elegans Y51F10.7 gene product C17F4.8 C17F4.8 Protein with strong similarity to C. elegans C40A11.3 gene product C17G1.1 C17G1.1 Protein of unknown function, has low similarity to uncharacterized C. elegans C17G1.2 C17G1.2 C17G1.2 Protein of unknown function, has low similarity to uncharacterized C. elegans C17G1.1 C17G1.3 C17G1.3 Protein containing a UDP-glucoronosyl and UDP-glucosyl transferase domain, has low similarity to UDP glycosyltransferase 1 family polypeptide A6 (mouse Ugt1a6), which catalyzes the glucoronidation of small planar phenolic molecules UDP-glucosyltransferase C17G1.4 C17G1.4 Protein with moderate similarity to H. sapiens MUC1 gene product, a transmembrane mucin C17G1.5 C17G1.5 Protein of unknown function, predicted to contain a glycosylphosphatidylinositol (GPI) lipid anchor C17G1.6 C17G1.6 Member of the astacin (M12A) family of metalloproteases, contains a CUB domain and a type 1 thrombospondin domain, has a region of low similarity to a region of C. elegans HCH-1, which is putative zinc-dependent metalloprotease involved in cell migration zinc metalloprotease; nas-37 encodes an extracellular matrix metalloprotease of the M12A (astacin) family that, in addition to its catalytic domain, contains an N-terminal secretion signal and EGF-like, CUB, and thrombospondin-1 domains in the C-terminal regulatory, or predicted protein-protein interaction, region; NAS-37 activity is required for efficient or full completion of the four larval molts in which older cuticle is shed and replaced by the newer, stage-specific cuticle; NAS-37 is able to induce the formation of an anterior contractile ring in cuticle from a parasitic nematode, suggesting that anterior cuticle digestion may be a conserved process in nematode ecdysis; in addition, NAS-37 may also play a minor role in normal cuticular collagen synthesis and/or processing; a NAS-37 translational reporter is expressed in the anterior hypodermis Hyp5, the excretory duct cell, and in pharyngeal, rectal, amphid, and vulval tissues; expression in Hyp5 can be see up to four hours prior to ecdysis; nas-37 promoter fusions additionally reveal expression in all hypodermal cells, although the functional significance of this more widespread expression is not yet known. C17G1.7 C17G1.7 Member of the cystathionine beta-synthase protein family cysteine synthase C17G10.1 C17G10.1 Member of the 2-oxoglutarate (2OG) and Fe(II)-dependent oxygenase family C17G10.2 C17G10.2 Protein containing two TPR (tetratrico peptide repeat) domains, which may mediate protein-protein interactions, has low similarity to S. cerevisiae Cns1p, which is a component of the Hsp90 chaperone complex TPR domain C17G10.4 C17G10.4 Member of the protein-tyrosine phosphatase family, which are involved in control of cell growth, proliferation, differentiation and transformation, has a region of moderate similarity to human CDC14A, which is a dual specificity protein phosphatase cdc-14 encodes a dual-specificity phosphatase, homologous to Cdc14p in S. cerevisiae; CDC-14 localizes to the central spindle in anaphase and to the midbody in telophase, and is required for cytokinesis and embryonic viability. C17G10.5 C17G10.5 Member of an uncharacterized protein family with weak similarity to Entemeba histolytica N-acetylmuraminidase C17G10.6 C17G10.6 Protein with weak similarity to C. elegans Y113G7B.12 gene product C17G10.7 C17G10.7 Protein of unknown function C17G10.9 C17G10.9 Protein with strong similarity to C. elegans F59E12.7 gene product C17H1.1 C17H1.1 Protein with strong similarity to C. elegans C17H1.7 gene product C17H1.2 C17H1.2 Protein of unknown function C17H1.3 C17H1.3 Protein of unknown function, has low similarity to uncharacterized C. elegans C17H1.5 C17H1.4 C17H1.4 Protein of unknown function, has low similarity to uncharacterized C. elegans F22G12.1 C17H1.5 C17H1.5 Protein of unknown function, has low similarity to uncharacterized C. elegans C17H1.3 C17H1.6 C17H1.6 Protein of unknown function, has high similarity to uncharacterized C. elegans C17H1.7 C17H1.7 C17H1.7 Protein of unknown function, has high similarity to uncharacterized C. elegans C17H1.6 C17H1.8 C17H1.8 Protein with strong similarity to C. elegans C17H1.4 gene product C17H11.1 C17H11.1 Protein of unknown function, has low similarity to uncharacterized C. elegans B0563.6 C17H11.2 C17H11.2 Protein of unknown function C17H11.3 C17H11.3 Member of the reverse transcriptase protein family, which are RNA-dependent DNA polymerases, has high similarity to uncharacterized C. elegans R05F9.4 reverse transcriptase C17H11.4 C17H11.4 Protein of unknown function, has high similarity to a region of ariadne ubiquitin-conjugating enzyme E2-binding protein homolog 1 (human ARIH1), which binds ubiquitin-conjugating enzyme E2-18 (human UBE2L3) and may play a role in protein ubiquitylation C17H11.5 C17H11.5 Protein of unknown function C17H11.6 C17H11.6 Protein with composite TRIAD zinc finger domain, has similarity to human Hs.78894 gene product, protein KIAA0161 isolated from human cell line KG-1 cDNA library, and D. melanogaster ARI2 C17H12.1 C17H12.1 Protein containing five WD domains (WD-40 repeats), which may mediate protein-protein interactions, has moderate similarity to intermediate chain 1 of cytoplasmic dynein (human DNCI1), which likely mediates cargo binding C17H12.10 C17H12.10 Protein of unknown function C17H12.11 C17H12.11 Protein with moderate similarity to C. elegans Y106G6D.4 gene product C17H12.12 C17H12.12 Protein containing a BTB (BR-C, ttk and babor) or POZ (Pox virus and zinc finger) domain, which are found in some DNA and actin binding proteins and may mediate protein-protein interactions C17H12.13 C17H12.13 Protein of unknown function C17H12.14 C17H12.14 Member of the ATP synthase E (31 kDa) subunit family, has low similarity to vacuolar H(+)-ATPase (V-ATPase) hydrophilic subunit E (S. cerevisiae Vma4p), which is the 27 kDa subunit of V1 sector ATPase C17H12.2 C17H12.2 Protein of unknown function C17H12.3 C17H12.3 Member of the protein-tyrosine phosphatase family, which are involved in control of cell growth, proliferation, differentiation and transformation, has moderate similarity to C. elegans F10G8.1, which is involved in embryogenesis or morphogenesis protein-tyrosine phosphatase C17H12.4 C17H12.4 Member of the carboxylesterase type B family, has low similarity to esterase 22 (egasyn, mouse Es22), which has a role in retaining beta-glucuronidase in the endoplasmic reticulum carboxylesterase C17H12.5 C17H12.5 Member of the protein-tyrosine phosphatase family, which are involved in control of cell growth, proliferation, differentiation and transformation, has low similarity to uncharacterized C. elegans Y57G11C.6 protein-tyrosine phosphatase C17H12.6 C17H12.6 Protein containing a DUF141 domain of unknown function, has high similarity to uncharacterized C. elegans C17H12.8 C17H12.8 C17H12.8 Protein of unknown function, has high similarity to uncharacterized C. elegans F08G5.6 C17H12.9 C17H12.9 Protein containing a homeobox (homeodomain) domain and a CUT domain, has moderate similarity to one cut domain family member 1 (hepatocyte nuclear factor-6) (mouse Onecut1), which is a transcriptional activator that regulates liver-specific genes homeobox protein; C17H12.9 encodes a ONECUT class CUT homeobox protein with a single N-terminal cut domain; the cut domain may be a compact DNA-binding domain composed of alpha helices; C17H12.9 is strongly affiliated with, and may be orthologous to, Drosophila ONECUT and mammalian HNF6 proteins; C17H12.9 has no obvious function in mass RNAi assays. C18A11.1 C18A11.1 Protein of unknown function, has weak similarity to C. elegans T24C4.3 C18A11.2 C18A11.2 Protein of unknown function C18A11.3 C18A11.3 Protein of unknown function C18A11.4 C18A11.4 Protein contains a putative SH2 domain C18A11.5 xol-1;C18A11.5 Protein that acts as a male/hermaphrodite sex determination switch C18A11.6 C18A11.6 Protein with moderate similarity to C. elegans F11A5.6 gene product C18A11.7 dim-1;C18A11.7 Putative member of immunoglobulin superfamily of proteins C18A3.1 C18A3.1 Protein of unknown function C18A3.2 C18A3.2 Member of the ZIP zinc transporter family, which may be metal transporters, has low similarity to uncharacterized C. elegans F30B5.7 C18A3.3 C18A3.3 Protein with moderate similarity to EBNA1-binding protein 2 (human EBNA1BP2), which is a nuclear protein that positively controls cell proliferation and is implicated in maintenance and segregation of latent Epstein Barr virus DNA episomes in human cells C18A3.4 C18A3.4 Protein of unknown function, has low similarity to uncharacterized C. elegans W01D2.5 C18A3.5 C18A3.5 Protein containing five RNA recognition motifs (RRM, RBD, or RNP), has moderate similarity to cytotoxic granule-associated RNA-binding protein 1 (human TIA1), which binds mRNA, functions in mRNA splicing, and may be associated with HIV progression RNA binding protein C18A3.6 rab-3;C18A3.6 GTP-binding protein of the rab family (ras superfamily), component of a neuronal transmission pathway that affects pharyngeal pumping, body thrashing, and male mating synaptic vesicle-associated GTP-binding protein; rab-3 encodes a rab3 homolog, a member of the Ras GTPase superfamily, and affects sensitivity to aldicarb and the distribution of synaptic vesicle populations and thereby affects synaptic transmission, track amplitude and speed of movement, chemotaxis to isoamyl alcohol, affects pharyngeal pump durations, and may only slightly affect male mating behavior; requires aex-3 for localization to synapse-rich regions in axons and it is expressed in most or all neurons. C18A3.7 C18A3.7 Protein of unknown function, has weak similarity to C. elegans ZC581.6 C18A3.8 C18A3.8 Protein containing one helix-loop-helix DNA-binding domain, which mediate protein dimerization helix-loop-helix transcription factor; hlh-14 encodes a basic helix-loop-helix (bHLH) transcription factor that is one of five C. elegans Achaete-Scute family homologs; HLH-14 activity is required generally for normal egg-laying, movement, body morphology, and larval development; more specifically, HLH-14 is required for proper neuronal development, particularly for regulation of the asymmetric cell division that gives rise to the PVQ/HSN/PHB neuroblasts and for normal differentiation of these neuroblast descendants, including their cell division patterns, migrations, and neurotransmitter expression; in specifying neuronal cell fates, genetic evidence suggests that hlh-14 acts together with hlh-2, which encodes the C. elegans E/Daughterless ortholog; HLH-14 is expresed exclusively in the embryo and detected in the left and right PVQ/HSN/PHB neuroblasts and their descendants, as well as in other cells identified, tentatively, as anterior neuroblasts and posterior neuroblasts such as Caapa. C18A3.9 C18A3.9 Protein of unknown function C18B10.1 C18B10.1 Protein containing a DUF40 domain of unknown function, which contain four conserved cysteines, has high similarity to uncharacterized C. elegans C18B10.2 C18B10.2 C18B10.2 Protein containing a DUF40 domain of unknown function, which contain four conserved cysteines, has high similarity to uncharacterized C. elegans C18B10.1 C18B10.3 C18B10.3 Protein containing a DUF40 domain of unknown function, which contain four conserved cysteines, has high similarity to uncharacterized C. elegans C04E12.1 C18B10.4 C18B10.4 Protein containing two DUF40 domains of unknown function, which contain four conserved cysteines, has low similarity to uncharacterized C. elegans C02A12.5 C18B10.5 C18B10.5 Protein containing a DUF40 domain of unknown function, which contain four conserved cysteines, has high similarity to uncharacterized C. elegans C04E12.1 C18B10.6 C18B10.6 Protein containing a DUF 227 domain of unknown function, high similarity to uncharacterized C. elegans Y45G12C.4 C18B10.7 C18B10.7 Member of the 7-transmembrane chemoreceptor family of G protein-coupled receptors (GPCR), has low similarity to C. elegans ODR-10, which is a G protein-coupled receptor involved in odorant response 7TM chemoreceptor, str family C18B10.8 C18B10.8 Member of the 7-transmembrane chemoreceptor family of G protein-coupled receptors (GPCR), has moderate similarity to uncharacterized C. elegans W02H5.6 7TM chemoreceptor, srh family C18B12.1 C18B12.1 Protein of unknown function C18B12.2 C18B12.2 Mmember of the secretin family of G protein-coupled receptors, contains a hormone receptor domain, has low similarity to corticotropin releasing hormone receptor 1 (mouse Crhr), which stimulates adenylyl cyclase 7 transmembrane receptor (Secretin family) C18B12.3 C18B12.3 Protein containing a homeobox (homeodomain) domain, has a region of low similarity to a region of C. elegans VAB-3, which is a homeodomain transcription factor required for morphogenesis of the head and gonads Homeobox domain; C18B12.3 encodes a paired-like homeodomain protein of the Q50 class, which has no obvious function in mass RNAi assays. C18B12.4 C18B12.4 Protein containing a C3HC4 type (RING) zinc finger, which may mediate protein-protein interactions, has a region of moderate similarity to a region of sperizin (mouse Ssrzf1), which may function in spermatogenesis Zinc finger, C3HC4 type (RING finger) C18B12.5 C18B12.5 Protein containing a DUF38 domain of unknown function, has high similarity to uncharacterized C. elegans H03G16.4 C18B12.6 C18B12.6 Protein of unknown function, has weak similarity to C. elegans K09E9.2 C18B2.1 C18B2.1 Protein of unknown function, has moderate similarity to uncharacterized C. elegans C18B2.2 C18B2.2 C18B2.2 Protein of unknown function, has moderate similarity to uncharacterized C. elegans C18B2.1 C18B2.3 C18B2.3 Protein of unknown function C18B2.4 C18B2.4 Protein containing a GRAM domain, which are found in glucosyltransferases, myotubularins and other putative membrane-associated proteins, has low similarity to WW domain binding protein 2 (human WBP2), which is involved in protein binding C18B2.5 C18B2.5 Protein of unknown function, has weak similarity to C. elegans F43B10.2 C18B2.6 C18B2.6 Member of the amiloride-sensitive sodium channel family, which are involved in sodium reabsorption, has weak similarity to neuronal amiloride-sensitive cation channel 1 (degenerin, rat Accn1), which is a non-voltage-dependent H+-gated sodium channel C18C4.1 C18C4.1 Protein of unknown function C18C4.10 klc-2;C18C4.10 Protein with high similarity to kinesin light chain 1 (mouse Klc1), which functions in anterograde axon cargo transport, contains nine TPR (tetratrico peptide repeat) domains, which may mediate protein-protein interactions kinesin light chain; klc-2 encodes a kinesin light chain and was identified as a protein that interacts with UNC-16 by the yeast two-hybrid system, this association suggests that KLC-2 may be involved in the regulation of synaptic vesicle localization by the UNC-16-JNK signaling complex. C18C4.2 C18C4.2 Putative ortholog of C. elegans Y75B8A.26 gene product trans-membrane protein C18C4.3 C18C4.3 Protein containing two UDP-glucoronosyl and UDP-glucosyl transferase domains, has low similarity to UDP glycosyltransferase 2 polypeptide B11 (human UGT2B11), which is a UDP-glucuronosyltransferase for which no substrate has been found UDP-glucuronosyltransferase C18C4.5 C18C4.5 Putative coiled-coil protein, has similarity to human CENPE, centromere protein E C18C4.6 C18C4.6 Protein of unknown function C18C4.7 C18C4.7 Protein of unknown function C18C4.9 C18C4.9 Protein with strong similarity to C. elegans C18C4.8 gene product C18D1.1 die-1;C18D1.1 Zinc finger protein required for epithelial cell rearrangement Zinc finger, C2H2 type (3 domains); die-1 encodes a C2H2 zinc finger protein containing four fingers, homologous to CG18265-PA in Drosophila; DIE-1 is autonomously required in the posterior dorsal hypodermis for intercalation, for morphogenesis in other embryonic tissues, and for normal postembryonic growth and vulval development. C18D1.2 C18D1.2 Protein with weak similarity to human sodium-dependent inorganic phosphate cotransporter NPT4, member of the major facilitator superfamily sodium/phosphate transporter C18D1.3 flp-4;C18D1.3 Putative FMRF-amide neurotransmitters FMRFamide-like peptide C18D11.1 C18D11.1 Protein of unknown function C18D11.2 C18D11.2 Protein containing an acyl CoA binding domain, has a region of moderate similarity to a region of peroxisomal D3,D2-enoyl-CoA isomerase (human PECI), which catalyzes isomerization of 3-cis-octenoyl-CoA to 2-trans-octenoyl-CoAm in fatty acid beta oxidation Acyl CoA binding protein; maa-1 encodes a predicted membrane-associated Acyl-CoA binding protein; loss of maa-1 activity via RNAi results in no obvious defects. C18D11.3 C18D11.3 Protein of unknown function C18D11.4 C18D11.4;Cetra2-beta;rsp-8 Protein with strong similarity to human SFRS10 protein and SR-like splicing factor and Drosophila TRA2, (putative RNA binding protein) RNA recognition motif. (aka RRM, RBD, or RNP domain) C18D11.5 C18D11.5 Protein of unknown function, has low similarity to a region of carbon catabolite repressor negative regulator of transcription complex subunit 2 (human CNOT2), which is a component of the CCR4-NOT global transcriptional regulator complex C18D4.1 C18D4.1 Protein with strong similarity to C. elegans K10G4.5 gene product C18D4.2 C18D4.2 Protein containing a DUF38 domain of unknown function C18D4.3 C18D4.3 Protein with strong similarity to C. elegans F28B1.6 gene product C18D4.4 C18D4.4 Protein with strong similarity to C. elegans Y61B8B.2 gene product C18D4.6 C18D4.6 Protein of unknown function, has strong similarity to uncharacterized C. elegans F31E9.6 C18D4.7 C18D4.7 Protein containing a DUF216 domain of unknown function, has high similarity to uncharacterized C. elegans F31E9.5 C18D4.8 C18D4.8 Member of an uncharacterized protein family This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins. C18D4.9 C18D4.9 Protein containing a DUF216 domain of unknown function, has low similarity to uncharacterized C. elegans Y68A4A.6 C18E3.1 C18E3.1 Protein of unknown function C18E3.2 C18E3.2 Putative ortholog of H. sapiens SMARCD3 protein, matrix associated SWI/SNF related and actin dependent regulator of chromatin The C18E3.2 gene encodes a homolog of Swp73/BAF60, a component of the SWI/SNF complex that is conserved from yeast to mammals and that is involved in chromatin remodeling; C18E3.2 is probably required during mitosis of the T cells for asymmetric cell division. C18E3.3 C18E3.3 Protein of unknown function C18E3.4 C18E3.4 Protein of unknown function C18E3.5 C18E3.5 Protein with high similarity to U5 snRNP-specific 40 kD protein (human HPRP8BP), which is a component of the U5 small nuclear ribonucleoprotein particle that binds to the 220 kDa component human PRP8, contains seven WD domains (WD-40 repeats) beta transducin C18E3.6 C18E3.6 Member of the CAP (adenylate-cyclase associated) protein family, has moderate similarity to adenylyl cyclase associated protein 2 (human CAP2), which regulates adenylyl cyclase function and may function in cell polarity regulation adenylyl cyclase-associated protein C18E3.7 C18E3.7 Piwi-related protein with similarity over the C-terminal region to human and D. melanogaster PIWI proteins and C. elegans PRG-1/PRG-2, all of which are involved in germ-line proliferation C18E3.8 hop-1;C18E3.8 Related to the H. sapiens PS1 and PS2 presenilins; required for the appropriate neurite connectivity of a small subset of interneurons, including AIY seven trans-membrane protein C18E3.9 C18E3.9 Protein of unknown function C18E9.1 C18E9.1 Protein containing four EF hand domains, which are found in signaling, buffering or transport proteins, has a region of high similarity to calmodulin 1 (human CALM1), which is involved in regulating the calcium-dependent activity of proteins and enzymes calmodulin; cal-2 encodes a calmodulin homolog required for embryonic development or viability; CAL-2 is closely similar to its paralogs CAL-1, CAL-3, CAL-4 and CMD-1. C18E9.10 C18E9.10 Protein of unknown function C18E9.11 ooc-5;C18E9.11 Putative ATPase that may function as a chaperone in the assembly or disassembly of proteins or protein complexes C18E9.2 C18E9.2 Protein of unknown function, has a region of low similarity to S. cerevisiae Sec62p, which is a component of ER protein-translocation subcomplex that includes Sec62p, Sec63p, Sec66p, and Sec72p Drosophila translocation protein 1 like C18E9.3 C18E9.3 Protein of unknown function, has weak similarity to C. elegans F40F11.2 The protein product of this gene is predicted to contain a glutamine/asparagine (Q/N)-rich ('prion') domain, by the algorithm of Michelitsch and Weissman (as of the WS77 release of WormBase, i.e., in wormpep77). C18E9.4 C18E9.4 Protein of unknown function C18E9.5 C18E9.5 Protein of unknown function C18E9.6 C18E9.6 Protein of unknown function, has high similarity to uncharacterized human TOMM40 C18E9.7 C18E9.7 Protein containing three fibronectin type III domains, which are involved in cell surface binding protein-tyrosine phosphatase like C18E9.8 C18E9.8 Protein of unknown function C18E9.8 is orthologous to the human gene JOINED TO JAZF1 (JJAZ1; OMIM:606245), which when mutated leads to disease. C18E9.9 C18E9.9 Protein of unknown function C18F10.2 C18F10.2 Protein containing a major sperm protein (MSP) domain, which are involved in sperm motility C18F10.4 srg-1;C18F10.4 G protein-coupled receptor, probably involved in chemosensation by sensory amphid neurons, no homolog found in human or D. melanogaster 7TM chemoreceptor, srg family C18F10.5 srg-2;C18F10.5 G protein-coupled receptor, probably involved in chemosensation by sensory amphid neurons, no homolog found in human or D. melanogaster 7TM chemoreceptor, srg family C18F10.6 srg-3;C18F10.6 G protein-coupled receptor, probably involved in chemosensation by sensory amphid neurons, no homolog found in human or D. melanogaster 7TM chemoreceptor, srg family C18F10.7 C18F10.7 Protein containing two ubiquitin interaction motifs and two ankyrin (Ank) repeats, which may mediate protein-protein interactions, has low similarity to uncharacterized human DKFZP566D1346 C18F10.8 srg-7;C18F10.8 G protein-coupled receptor, probably involved in chemosensation by sensory amphid neurons, no homolog found in human or D. melanogaster 7TM chemoreceptor, srg family C18F3.2 lad-1;C18F3.2 Member of the L1 family of cell adhesion molecules (L1CAMs); involved in embryonic and gonadal morphogenesis neural adhesion protein; sax-7 encodes the C. elegans ortholog of L1CAM; SAX-7 is ubiquitously expressed at sites of cell-cell contact, and is required for germline development, embryonic morphogenesis, and gonadal morphogenesis; SAX-7 interacts physically with the ankyrin UNC-44, and nonphosphorylated SAX-7 is colocalized with UNC-44 at sites of cellular contact in vivo. C18G1.1 C18G1.1 Protein of unknown function C18G1.2 C18G1.2 Protein containing a GATA-type zinc finger domain, has low similarity to a region of C. elegans ELT-3, which is a GATA-binding factor required for hypodermal cell differentiation GATA transcription factor C18G1.3 C18G1.3 Protein of unknown function, has high similarity to uncharacterized C. elegans F56H6.6 C18G1.4 C18G1.4 Protein of unknown function, has high similarity to uncharacterized C. elegans PGL-1, which is predicted to be a component of P granules that binds RNA C18G1.5 H1.4;C18G1.5 Histone H1 histone H1 C18G1.6 C18G1.6 Protein of unknown function, has high similarity to uncharacterized C. elegans E03H4.5 C18G1.7 C18G1.7 Protein of unknown function, has moderate similarity to uncharacterized C. elegans F39G3.2 C18G1.8 C18G1.8 Member of the glycosyl transferase family 11, which hydrolyze the glycosidic bond between two or more carbohydrates, has high similarity to uncharacterized C. elegans C14C6.3 C18G1.9 C18G1.9 Protein of unknown function, has strong similarity to uncharacterized C. elegans C14C11.1 C18H2.1 C18H2.1 Protein containing four WSN domains of unknown function, four ankyrin (Ank) repeats, which may mediate protein-protein interactions, and four BRCA1 (breast cancer type 1) C terminus (BRCT) domains, which are found in some cell cycle checkpoint proteins C18H2.2 C18H2.2 Protein of unknown function, has high similarity to uncharacterized C. elegans K06B9.4 C18H2.3 C18H2.3 Protein containing four ankyrin (Ank) repeats, which may mediate protein-protein interactions, three BRCA1 (breast cancer type 1) C terminus (BRCT) domains, which are found in some cell cycle checkpoint proteins, and two WSN domains of unknown function C18H2.4 C18H2.4 Protein containing two BRCA1 (breast cancer type 1) C terminus (BRCT) domains, which are found in some cell cycle checkpoint proteins and one WSN domain of unknown function, has low similarity to uncharacterized C. elegans F37A4.4 C18H2.4 is orthologous to the human gene GLOMULIN (FAP48; OMIM:601749), which when mutated leads to disease. C18H7.1 C18H7.1 Protein containing two von Willebrand factor (vWF) type A domains, has weak similarity to matrilin 1 (cartilage matrix protein, mouse Matn1), which is a putative component of the extracellular matrix that forms homodimers and binds collagen and aggrecan C18H7.2 C18H7.2 Protein with high similarity to C. elegans UNC-7, which is required in motor neurons for coordinated locomotion, member of the integral membrane innexin family, which are involved in the formation of gap junctions inx-18 encodes a predicted member of the innexin family. C18H7.3 C18H7.3 Protein containing two collagen triple helix repeats, which are found in some extracellular proteins and a nematode cuticle collagen N-terminal domain, has moderate similarity to a region of alpha 1 subunit of type XI collagen (human COL11A1) cuticular collagen C18H7.4 C18H7.4 Protein containing a Src homology 2 (SH2) and protein kinase domain, has low similarity to fer tyrosine kinase (mouse Fert2), which may play roles in cytoskeletal reorganization and regulation of nuclear suppressive activities during the cell cycle protein kinase C18H7.5 C18H7.5 Protein of unknown function C18H7.6 C18H7.6 Protein of unknown function C18H7.7 C18H7.7 Protein of unknown function, has moderate similarity to uncharacterized C. elegans R102.8 C18H7.8 C18H7.8 Protein containing a DUF32 domain of unknown function, has weak similarity to uncharacterized C. elegans Y41E3.15 7TM chemoreceptor, srt family C18H7.9 C18H7.9 Protein with strong similarity to C. elegans C23H5.1 gene product C18H9.1 C18H9.1 Protein of unknown function Initiation factor (IF-2) C18H9.2 C18H9.2 Protein of unknown function C18H9.3 C18H9.3 Protein containing a GYF (glycine, tyrosine, phenylalanine) domain, which are proline-binding domains C18H9.5 C18H9.5 Member of the sugar (and other) transporter family, has low similarity to solute carrier family 17 member 1 (human SLC17A1), which is involved in sodium-dependent phosphate transport and mediates organic anion transport at the renal apical membrane sodium/phosphate transport protein C18H9.6 C18H9.6 Protein of unknown function, has weak similarity to C. elegans T19D12.1 C18H9.7 C18H9.7 Protein containing a C3HC4 type (RING) zinc finger, has low similarity to receptor-associated protein of the synapse (mouse Rapsn), which is associated with acetylcholine receptors and required for agrin (Agrn) signaling through the MuSK complex postsynaptic protein; rpy-1 is orthologous to the human gene 43KDA ACETYLCHOLINE RECEPTOR-ASSOCIATED PROTEIN (RAPSN; OMIM:601592), which when mutated leads to congenital myasthenic syndrome. C18H9.8 C18H9.8 Putative coiled-coil protein, has weak similarity to myosin heavy chains C23F12.1 C23F12.1 Member of an uncharacterized protein family C23F12.2 C23F12.2 Protein with similarity to human FLNC gene product (see BLAST), gamma filamin C (actin-binding protein-280) actin-binding C23F12.3 C23F12.3 Protein of unknown function C23F12.4 C23F12.4 Protein of unknown function C23G10.1 C23G10.1 Member of the protein phosphatase protein family Protein phosphatase C23G10.10 C23G10.10 Protein of unknown function C23G10.11 C23G10.11 Protein of unknown function C23G10.2 C23G10.2 Member of the YjgF family, which may be a ligand activated enzyme, has low similarity to S. cerevisiae Mmf1p, which is a protein important for maintenance of mitochondrial DNA that may also be involved in isoleucine-dependent transaminase activity C23G10.3 C23G10.3 Member of the ribosomal protein S3 protein family, has a possible KH domain Ribosomal protein S3; rps-3 encodes a small ribosomal subunit S3 protein that contains a KH RNA-binding domain and by homology,is predicted to function in protein biosynthesis; in C. elegans, RPS-3 activity is required for embryonic and germline development, as well as the overall health of the animal. C23G10.4 rpn-2;C23G10.4 Protein containing eleven proteasome or cyclosome repeat domains, has low similarity to S. cerevisiae Rpn2p, which is a non-ATPase component of the 26S proteasome complex and functions in RNA polymerase II transcription elongation tRNA processing protein SEN3; rpn-2 encodes a non-ATPase subunit of the 26S proteasome's 19S regulatory paritcle (RP) base subcomplex; RPN-2 is required for embryonic, larval, and germline development and by homology, is predicted to function in unfolding and recognition of protein substrates and/or recycling of ubiquitin moieties during protein degradation; RPN-2 is expressed sporadically at all stages of development in the pharynx, intestine, body wall muscle, somatic gonad, neurons, and hypodermis. C23G10.5 C23G10.5 Protein of unknown function, has weak similarity to C. elegans R11D1.2 C23G10.6 C23G10.6 Protein containing two UDP-glucoronosyl and UDP-glucosyl transferase domains, has low similarity to olfactory UDP-glucuronosyltransferase (human UGT2A1), which catalyzes the glucuronidation of substrates such as odorants, steroids, drugs, and carcinogens UDP-glucosyltransferase C23G10.7 C23G10.7 Protein of unknown function C23G10.8 C23G10.8 Putative ortholog of C. elegans C23G10.9 gene product S. pombe adenylyl cyclase-associated protein (weak) C23H3.1 egl-26;egl-48;C23H3.1 Required for vulval morphogenesis egl-26 encodes a novel protein that contains an H-box/NC domain that is highly conserved with CBP01801 in C. briggsae and is required for embryonic and larval viability, egg-laying, fertility, and affects the connection of the uterus to the vulva; required in the primary vulval lineage for vulF morphogenesis and is expressed in many cells, but is expressed near the vulva and uterus only during the L4 larval stage. C23H3.2 C23H3.2 Protein of unknown function C23H3.3 C23H3.3 Protein containing a KH domain, which may bind RNA C23H3.4 C23H3.4 Protein with high similarity to serine palmitoyltransferase long chain base subunit 1 (mouse Sptlc1), which catalyzes the first step in ceramide synthesis and acts in sphingolipid metabolism, contains an aminotransferase class I and II domain aminotransferase; C23H3.4 encodes a putative serine palmitoyltransferase required for normal embryonic and larval developement, locomotion, and speed of growth. C23H3.5 C23H3.5 Protein of unknown function C23H3.9 C23H3.9 Member of the metallo-beta-lactamase family C23H4.1 cab-1;C23H4.1 Component of a neuronal transmission pathway that affects defecation and dauer larval mobility Novel protein which has a C-terminal motif weakly homologous to mouse NPDC-1 and is involved in syaptic regulation; it is expressed in various neurons including ventral cord and tail ganglion neurons; it physically interacts with AEX-3, which is a guanine nucleotide exchange factor for the Rab3 GTPase. C23H4.2 C23H4.2 Member of the carboxylesterase type B family, has low similarity to esterase 22 (egasyn, mouse Es22), which is an esterase of the nonspecific carboxylesterase family that has a role in retaining beta-glucuronidase in the endoplasmic reticulum carboxyesterase C23H4.3 C23H4.3 Member of the carboxylesterase type B family, has a region of low similarity to esterase 22 (egasyn, mouse Es22), which is an esterase with a role in retaining beta-glucuronidase in the endoplasmic reticulum carboxyesterase C23H4.4 C23H4.4 Member of the carboxylesterase type B family, has low similarity to carboxylesterase-related protein (human PCE3), which hydrolyzes esters, amides and thioesters and is involved in the metabolism of drugs and endogenous and foreign toxicants carboxyesterase C23H4.5 C23H4.5 Putative ortholog of C. elegans E01G6.3 gene product C23H4.6 C23H4.6 Putative coiled-coil protein, has strong similarity to S. cerevisiae Rhc18p, a protein involved in recombination repair Yeast RAD18 protein like C23H5.1 C23H5.1 Protein with strong similarity to C. elegans C18H7.9 gene product C23H5.2 C23H5.2 Protein of unknown function, has weak similarity to C. elegans Y119D3_465.P globin C23H5.3 C23H5.3 Protein of unknown function C23H5.7 C23H5.7 Member of the cyclic nucleotide gated ion channel protein family cyclic nucleotide-binding protein C23H5.8 C23H5.8 Protein of unknown function C23H5.9 C23H5.9 Protein of unknown function containing a Ground-like domain, has weak similarity to C. elegans Y75B8A.W C24A1.1 C24A1.1 Protein of unknown function C24A1.2 C24A1.2 Protein containing an ETS domain, which bind promoter DNA, has a region of moderate similarity to a region of new Ets related factor 2 (E74-like factor 2) human ELF2, which is an ETS transcriptional activator C24A1.3 C24A1.3 Protein containing a protein kinase domain and nine ankyrin (Ank) repeats, which may mediate protein-protein interactions, has a region of moderate similarity to a region of mixed lineage kinase with a leucine zipper and a sterile alpha motif (human ZAK) C24A1.4 C24A1.4 Member of the transposase family, which are required for excising and inserting mobile genetic elements transposase C24A11.1 C24A11.1 Protein with moderate similarity to C. elegans F37A8.2 gene product C24A11.2 C24A11.2 Protein containing a FERM domain (Band 4.1 family), which link cytoplasmic proteins to membranes, has weak similarity to erythrocyte membrane protein band 4.1 (human EPB41), which has a role in maintaining cell shape C24A11.5 C24A11.5 Protein of unknown function C24A11.6 C24A11.6 Protein of unknown function C24A11.8 C24A11.8 Protein of unknown function, has high similarity to C. elegans C24A11.2 frm-4 encodes a predicted transmembrane protein that contains an N-terminal FERM (Band 4.1-ezrin-radixin-moesin) domain; by homology, FRM-4 is predicted to function as a membrane-cytoskeleton linker protein that plays a role in cell adhesion, migration, or organization of cell surface structures; however, as loss of frm-4 activity via large-scale RNAi screens does not result in any obvious abnormalities, the precise role of FRM-4 in C. elegans development and/or behavior is not yet known. C24A11.9 C24A11.9 Member of the polyprenyl synthetase family, which function in isoprenoid biosynthesis, has low similarity to hexaprenyl pyrophosphate synthetase (S. cerevisiae Coq1p), which catalyzes the first step in coenzyme Q (ubiquinone) biosynthesis pathway hexaprenyl pyrophosphate synthetase C24A3.1 C24A3.1 Protein with strong similarity to C. elegans M03A1.5 gene product Neuropeptide anthorfamide C24A3.2 C24A3.2 Protein of unknown function, has weak similarity to C. elegans B0464.3 C24A3.4 C24A3.4 Member of the CAIB or BAIF family of diverse enzymes, has a region of moderate similarity to alpha-methylacyl-CoA racemase (mouse Amacr), which mediates for isomerization of alpha-methyl-branched fatty acids and has role in lipid metabolism E. coli L-carnitine dehydratase C24A3.5 twk-2;C24A3.6;C24A3.5 Member of the 4 TM potassium channel protein family C24A3.7 C24A3.7 Member of the reverse transcriptase protein family, which are RNA-dependent DNA polymerases, has very strong similarity to uncharacterized C. elegans F28E10.3 reverse transcriptase C24A3.8 C24A3.8 Protein with strong similarity to C. elegans F31A9.1 gene product C24A8.1 C24A8.1 Member of the rhodopsin family of G protein-coupled receptors (GPCR), has low similarity to dopamine D2 receptor (mouse Drd2), which inhibits adenylyl cyclase and glutamaterigic neurotransmission and is important for locomotory behavior G-protein coupled receptor C24A8.3 C24A8.3 Protein of unknown function, has a region of low similarity to a region of nuclear receptor coactivator 6 (mouse Ncoa6), which interacts with basal factors, transcription integrators, and ligand-dependent nuclear receptors to activate transcription The protein product of this gene is predicted to contain a glutamine/asparagine (Q/N)-rich ('prion') domain, by the algorithm of Michelitsch and Weissman (as of the WS77 release of WormBase, i.e., in wormpep77). C24A8.4 C24A8.4 Member of the rhodopsin family of G protein-coupled receptors (GPCR), has a region of high similarity to yeast Sps1Ste20-related kinase 3 (mouse Stk4), which a protein kinase that may function in apoptosis G-protein coupled receptor C24A8.5 C24A8.5 Protein of unknown function C24B5.1 C24B5.1 Member of the rhodopsin family of G protein-coupled receptors (GPCR), has low similarity to uncharacterized C. elegans F16C3.1 C24B5.2 C24B5.2 Member of the proteasome complex protein family ATPase C24B5.3 ptr-1;C24B5.3 Member of the patched family, which are transmembrane receptors, has weak similarity to Niemann-Pick disease type C1 (human NPC1), which is a lysosomal protein that plays a role cholesterol transport C24B5.4 C24B5.4 Protein of unknown function C24B5.5 C24B5.5 Protein with moderate similarity to C. elegans M02G9.1 gene product The protein product of this gene is predicted to contain a glutamine/asparagine (Q/N)-rich ('prion') domain, by the algorithm of Michelitsch and Weissman (as of the WS77 release of WormBase, i.e., in wormpep77). C24B9.1 C24B9.1 Member of the 7-transmembrane chemoreceptor family of G protein-coupled receptors (GPCR), has low similarity to C. elegans ODR-10, which is a G protein-coupled receptor involved in odorant response 7TM chemoreceptor, str family C24B9.10 C24B9.10 Protein of unknown function, has moderate similarity to uncharacterized C. elegans C24B9.7 7TM chemoreceptor, srg family C24B9.11 C24B9.11 Protein of unknown function, has high similarity to uncharacterized C. elegans ZC317.5 7TM chemoreceptor, srg family C24B9.12 C24B9.12 Protein of unknown function, has high similarity to uncharacterized C. elegans ZK678.6 7TM chemoreceptor, srg family C24B9.13 C24B9.13 Protein of unknown function, has moderate similarity to uncharacterized C. elegans F41H8.3 C24B9.2 C24B9.2 Protein containing a DUF32 domain of unknown function, has high similarity to uncharacterized C. elegans C16D9.7 7TM chemoreceptor, srt family C24B9.3 C24B9.3 Protein containing a von Willebrand factor (vWF) type A domain C24B9.4 C24B9.4 Protein containing a DUF32 domain of unknown function, has high similarity to uncharacterized C. elegans C24B9.6 7TM chemoreceptor, srt family C24B9.5 C24B9.5 Protein containing a DUF32 domain of unknown function, has high similarity to uncharacterized C. elegans R08F11.2 7TM chemoreceptor, srt family C24B9.6 C24B9.6 Protein containing a DUF32 domain of unknown function, has high similarity to uncharacterized C. elegans C24B9.4 7TM chemoreceptor, srt family C24B9.7 C24B9.7 Protein of unknown function, has moderate similarity to uncharacterized C. elegans C24B9.10 7TM chemoreceptor, srg family C24B9.8 C24B9.8 Member of the 7-transmembrane chemoreceptor family of G protein-coupled receptors (GPCR), has low similarity to C. elegans ODR-10, which is involved in odorant response 7TM chemoreceptor, str family C24B9.9 C24B9.9 Protein with strong similarity to C. elegans T04C12.1 gene product C24D10.1 C24D10.1 Member of the protein-tyrosine phosphatase family, which are involved in control of cell growth, proliferation, differentiation and transformation, has high similarity to uncharacterized C. elegans Y57G11C.6 C24D10.2 C24D10.2 Protein of unknown function, has strong similarity to uncharacterized C. elegans F11G11.4 C24D10.4 C24D10.4 Protein of unknown function C24D10.5 C24D10.5 Protein of unknown function, has high similarity to uncharacterized C. elegans T11F8.1 C24D10.6 C24D10.6 Protein of unknown function C24D10.7 C24D10.7 Protein of unknown function C24D10.8 C24D10.8 Protein of unknown function C24F3.1 C24F3.1 Protein with moderate similarity to translocating chain-associating membrane protein (human TRAM), which is a putative endoplasmic reticulum receptor that stimulates translocation of secretory proteins C24F3.2 C24F3.2 Protein containing a dual specificity phosphatase catalytic domain, has low similarity to rat Dusp12, which is a dual specificity phosphatase that binds to glucokinase (Gck) and stimulates its activity Dual specificity phosphatase, catalytic domain C24F3.3 C24F3.3 Member of the astacin (M12A) family of metalloproteases, has a region of moderate similarity to a region of tolloid-like 2 (human TLL2), which processes the extracellular matrix crosslinking prolysyl oxidase (human LOX) zinc metallopeptidase (M12A family) C24F3.4 C24F3.4 Member of the eukaryotic NAD synthetase branch in the nitrilase superfamily, which also includes human FLJ10631, S. cerevisiae Qns1p and S. pombe SPBC23E6.03cp that play a role in utilization of glutamine as an ammonia source C24F3.5 C24F3.5 Member of the ABC transporter family, which are involved in translocation across biological membranes, has a region of weak similarity to a region of ATP-binding cassette subfamily A member 4 (mouse Abca4), which is involved in visual dark adaptation ABC transporters C24F3.6 C24F3.6 Protein with high similarity to C. elegans SQT-3, contains two collagen triple helix repeats, which are found in some extracellular proteins, and a nematode cuticle collagen N-terminal domain CUTICLE COLLAGEN 1 C24G6.1 C24G6.1 Protein of unknown function C24G6.2 C24G6.2 Protein containing two protein kinase domains and one fibronectin type III domain, which are involved in cell surface binding, has a region of moderate similarity to a region of fibroblast growth factor receptor 1 (mouse Fgfr1) protein kinase C24G6.3 C24G6.3 Protein of unknown function, has a region of low similarity to a region of human MMS19L, which may play a role in both repair and transcription by interacting with the XPB and XPD subunits of the nucleotide excision repair transcription factor human TFIIH C24G6.4 csr-1;nhr-47;C24G6.4 Putative nuclear hormone receptor, has strong similarity to C. elegans R09G11.2, has similarity to human and D. melanogaster HNF4 hepatocyte nuclear factors zinc finger protein C24G6.5 C24G6.5 Protein containing one DnaJ domain and one cysteine-rich DnaJ central domain, has high similarity to a region of dnaJ homolog member 2 of subfamily A (human DNAJA2), which is a cochaperone associated with cancer cell growth inhibition when upregulated This gene encodes a protein containing a DnaJ ('J') domain. C24G6.6 C24G6.6 Member of the flavin containing amine oxidase family, has low similarity to uncharacterized C. elegans F25C8.2 C24G6.7 C24G6.7 Protein of unknown function containing a Ground-like domain, has moderate similarity to C. elegans F42C5.7 C24G6.8 C24G6.8 Protein containing a a UBA (ubiquitin associated) or TS-N domain and a UPF0099 domain of unknown function C24G7.1 C24G7.1 Member of the amiloride-sensitive sodium channel family, has similarity to human and D. melanogaster amiloride-sensitive cation channels C24G7.2 C24G7.2 Member of the amiloride-sensitive sodium channel family, has similarity to human and D. melanogaster amiloride-sensitive cation channels C24G7.3 C24G7.3 Protein of unknown function, has low similarity to uncharacterized C. elegans ZC53.3 mariner transposase C24G7.4 C24G7.4 Member of the amiloride-sensitive sodium channel family, has similarity to human and D. melanogaster amiloride-sensitive cation channels C24G7.5 C24G7.5 Putative muscle protein, member of Ig superfamily C24H10.1 C24H10.1 Protein of unknown function, has low similarity to uncharacterized C. elegans R04F11.1 C24H10.1 encodes a claudin homolog that may be required for normal cohesion of apical junctions in epithelia; C24H10.1 is worm-specific, with obvious homologs only in C. elegans; C24H10.1 has no obvious function in mass RNAi assays; claudins are integral membrane proteins with four transmembrane sequences that are found in mammalian tight junctions (TJs), induce TJs when transgenically expressed in cells normally lacking them, and can mediate the specific conductance of of specific ions (e.g., magnesium or calcium) through TJs while blocking the flow of water. C24H10.2 C24H10.2 Protein of unknown function C24H10.3 C24H10.3 Protein of unknown function C24H10.4 C24H10.4 Protein of unknown function C24H10.5 uvt-2;C24H10.5 Protein containing four EF hand domains, which are found in signaling, buffering or transport proteins, has moderate similarity to calmodulin 1 (mouse Calm1), which is involved in regulation of calcium-dependent activity of proteins and enzymes EF-hand calcium binding protein; uvt-2 encodes a protein that contains four EF-hand calcium binding motifs with similarity to human calmodulin; mRNA weakly expressed in L1 through L4 larval stages and in the adult hermaphrodite. | uvt-2 encodes a protein that contains four EF-hand calcium binding motifs with some similarity to human calmodulin; mRNA weakly expressed in L1 through L4 larval stages and in the adult hermaphrodite. C24H11.1 C24H11.1 Member of the serine or threonine protein phosphatase family, has moderate similarity to serine-threonine protein phosphatase PP1-2 minor type (S. pombe Sds21p) Protein phosphatase-1 (PP1) C24H11.2 C24H11.2 Member of the serine or threonine protein phosphatase family, has moderate similarity to S. pombe Sds21, which is a minor type serine-threonine protein phosphatase Protein phosphatase-1 (PP1) C24H11.3 C24H11.3 Protein containing a T-box domain, which bind DNA, has a region of moderate similarity to a region of t-box 6 (human TBX6), which is a DNA-binding protein that may be involved in embryonic paraxial mesoderm formation and somitogenesis T-box C24H11.4 C24H11.4 Protein of unknown function, has low similarity to uncharacterized C. elegans Y45G12C.9 C24H11.5 C24H11.5 Protein of unknown function C24H11.6 C24H11.6;CeSrb7 Member of the signal peptidases type I family, has a region of moderate similarity to suppressor of RNA polymerase B7 (human SURB7), which is a component of both an RNA polymerase II holoenzyme and a transcriptional regulation complex C24H11.7 C24H11.7 Protein containing a Sec7 domain which are found in guanine nucleotide exchange factors for ARF family GTPases, has a region of weak similarity to S. cerevisiae Gea2p, which is a component of a complex with guanine-nucleotide-exchange activity for ARF This gene encodes a protein predicted by Eisenberg and coworkers, with 52% accuracy, to be mitochondrial. C24H11.8 C24H11.8 Member of the ion transport family, which include calcium, sodium, and potassium channels, has a region of low similarity to a region of potassium channel subfamily K member 2 (mouse Kcnk2) C24H12.1 C24H12.1 Protein containing an F-box domain, which serve as a link between a target protein and a ubiquitin-conjugating enzyme This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins; its encoded protein also contains a Pfam-B45 motif of presently unknown function. C24H12.10 C24H12.10 Protein containing an F-box domain, which serve as a link between a target protein and a ubiquitin-conjugating enzyme This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins. C24H12.11 C24H12.11 Protein containing an F-box domain, which serve as a link between a target protein and a ubiquitin-conjugating enzyme, has high similarity to uncharacterized C. elegans T27A1.2 This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins; its encoded protein also contains a Pfam-B45 motif of presently unknown function. C24H12.2 C24H12.2 Putative ortholog of C. elegans C24H12.5 gene product C24H12.4 C24H12.4 Member of the DEAD or DEAH box ATP-dependent RNA helicase family and contains two helicase conserved C-terminal domains, has moderate similarity to nucleolar RNA helicase 61 (human NOH61), which may function in ribosome synthesis helicase C24H12.5 C24H12.5 Putative ortholog of C. elegans C24H12.2 gene product C24H12.6 C24H12.6 Protein of unknown function C24H12.7 C24H12.7 Protein containing an F-box domain, which serve as a link between a target protein and a ubiquitin-conjugating enzyme This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins. C24H12.8 C24H12.8 Protein containing an F-box domain, which serve as a link between a target protein and a ubiquitin-conjugating enzyme, has high similarity to uncharacterized C. elegans T27A1.3 This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins. C24H12.9 C24H12.9 Protein of unknown function, has high similarity to uncharacterized C. elegans Y73E7A.5 C25A1.1 C25A1.1 Protein of unknown function C25A1.10 dao-5;C25A1.10 Protein with low similarity to nucleolar phosphoprotein 140 (rat Nopp140), which is a transcription co-activator that interacts with rat Gtf2b and rat Cebpb, shuttles between the cytoplasm and nucleolus, and may act as a nuclear import or export chaperone dao-5 encodes a predicted nucleolar phosphoprotein related to Saccharomyces cerevisiae SRP40 and the vertebrate Nopp140 proteins that may play a role in rRNA gene transcription and nucleolar structural organization; dao-5 expression is negatively regulated by the DAF-2/insulin-like receptor and positively regulated by the DAF-16/fork-head transcription factor, suggesting that dao-5 may be involved in life-span determination; dao-5 is strongly expressed in dauer larvae. C25A1.11 aha-1;C25A1.11 Putative aryl-hydrocarbon receptor nuclear translocator; member of the basic helix-loop-helix DNA-binding domain family aryl hydrocarbon receptor nuclear translocator; aha-1 encodes an ortholog of human aryl-hydrocarbon receptor nuclear translocator; interacts with AHR-1 and HIF-1 in vitro, requires HIF-1 for proper localization, and is expressed ubiquitously. C25A1.12 C25A1.12 Protein of unknown function, has moderate similarity to uncharacterized human FLJ12816 C25A1.13 C25A1.13 Protein with weak similarity to human NDUFA2 , a subunit of NADH-ubiquinone oxidoreductase NADH-ubiquinone oxidoreductase B8 subunit C25A1.15 C25A1.15 Protein of unknown function C25A1.2 C25A1.2 Protein containing a fork head domain, which are found in transcription factors involved in cell fate determination, has a region of high similarity to a region of C. elegans UNC-130, which is a transcription factor nuclear factor 5 like; fkh-10 encodes one of 15 forkhead transcriptional regulators encoded by the C. elegans genome; by homology, FKH-10 is predicted to function as a transcription factor that regulates gene expression during development; however, as loss of fkh-10 activity via RNA-mediated interference (RNAi) does not result in any obvious abnormalities, the precise role of FKH-10 in C. elegans development and/or behavior is not yet known; nevertheless, reporter gene studies indicate that throughout larval and adult stages, fkh-10 expression is detected almost exclusively in six pairs of neuronal nuclei near the terminal bulb of the pharynx, suggesting that FKH-10 may have a specific function in neuronal differentiation. C25A1.3 C25A1.3 Putative mRNA cap methyltransferase, has strong similarity to human and yeast mRNA cap methyltransferases Yeast ABD1 protein like C25A1.4 C25A1.4 Protein containing three RNA recognition motifs (RRM, RBD, or RNP), has low similarity to myocyte-specific enhancer-binding factor (human MEF-2), which interacts with muscle-specific enhancers to regulate transcription and likely myoblast differentiation RNA binding protein C25A1.5 C25A1.5 Protein with low similarity to S. cerevisiae Scs7p, which is a ceramide hydroxylase that hydroxylates the C-26 fatty-acyl moiety of inositol-phosphorylceramide Yeast hypothetical 44.9 KD protein like C25A1.6 C25A1.6 Protein with high similarity to S. cerevisiae Nop10p, which is a nucleolar protein component of box H/ACA small nucleolar RNAs (snoRNAs) which direct rRNA pseudouridinylation C25A1.7 C25A1.7 Member of the class I isoleucyl, leucyl, valyl, and methionyl (I, L, M, and V) tRNA synthetase family, has low similarity to mitochondrial isoleucyl-tRNA synthetase (S. cerevisiae Ism1p) isoleucyl-tRNA synthetase (mitochondrial); irs-2 encodes a predicted mitochondrial isoleucyl-tRNA synthetase (IleRS), a class I aminoacyl-tRNA synthetase that catalyzes the attachment of isoleucine to its cognate tRNA and is thus required for protein biosynthesis; loss of irs-2 activity via RNA-mediated interference (RNAi) does not result in any abnormalities, suggesting possible functional redundancy with irs-1. C25A1.8 C25A1.8 Member of the C-type lectin family lectin C25A1.9 C25A1.9 Protein of unknown function C25A11.1 C25A11.1 Protein of unknown function, has high similarity to uncharacterized C. elegans C25A11.2 C25A11.2 C25A11.2 Protein containing a BTB (BR-C, ttk and babor) or POZ (Pox virus and zinc finger) domain, which are found in some DNA and actin binding proteins and may mediate protein-protein interactions, has high similarity to uncharacterized C. elegans C25A11.1 C25A11.3 ajm-1;jam-1;C25A11.4;C25A11.3 Localized to the apical zonula adherens encircling the epithelium of C. elegans; recognized by monoclonal antibody MH27 which stains gap junctions C25A6.B C25A6.1;C25A6.B Member of the protein phosphatase protein family C25A8.1 C25A8.1 Protein with similarity to members of the major sperm-specific protein (MSP) family, small protein (37 amino acids) with near identity to the N-terminal region of MSP proteins truncated MSP C25A8.2 C25A8.2 Protein of unknown function, has high similarity to uncharacterized C. elegans R02D5.7 C25A8.4 C25A8.4 Member of the glycosyl hydrolase 18 family, has a region of weak similarity to chitinase 1 (chitotriosidase, human CHIT1), which catalyzes the hydrolysis of chitin and is associated with Gaucher disease and chitotriosidase deficiency C25A8.5 C25A8.5 Protein containing a Src homology 2 (SH2) domain and a protein kinase domain, has moderate similarity to fer (fps/fes related) tyrosine kinase (mouse Fert2), which may mediate cell-cell signaling and play roles in cytoskeletal reorganization protein-tyrosine kinase C25B8.1 klq-1;C25B8.1;nKQT1 Putative KQT potassium channel, putative ortholog of human potassium voltage-gated channel KCNQ3 voltage-gated potassium channel; The kqt-1 gene encodes a homolog of human KCNQ2, which when mutated leads to benign familial neonatal convulsions (OMIM:121200). C25B8.3 cpr-6;C25B8.3 Member of the Cathepsin B-like Cysteine Protease family C25B8.4 C25B8.4 Member of the lectin protein family, putative paralog of C. elegans C25A1.8 asialoglycoprotein receptor C25B8.5 C25B8.5 Member of the rhodopsin family of G protein-coupled receptors (GPCR), has low similarity to uncharacterized C. elegans C48C5.3 alpha adrenergic receptor C25B8.6 C25B8.6 Protein containing a nuclear hormone receptor C4-type zinc finger domain and a nuclear hormone receptor ligand-binding domain, has weak similarity to retinoid X receptor alpha (mouse Rxra), which is a high affinity receptor for 9-cis retinoic acid C25D7.1 C25D7.1 Protein containing a major sperm protein (MSP) domain, which are involved in sperm motility, has high similarity to uncharacterized C. elegans K07F5.7 C25D7.10 C25D7.10 Protein contains a putative DnaJ domain, putative paralog of C. elegans C01G10.12 protein C25D7.12 C25D7.12 Protein containing a major sperm protein (MSP) domain, which are involved in sperm motility, has strong similarity to uncharacterized C. elegans C25D7.2 C25D7.2 C25D7.2 Protein containing a major sperm protein (MSP) domain, which are involved in sperm motility, has strong similarity to uncharacterized C. elegans C25D7.12 C25D7.3 sdc-3;dpy-29;C25D7.3 Zinc finger protein required for sex determination and dosage compensation Zinc finger, C2H2 type; sdc-3 encodes a protein that contains two mutationally separable domains: a zinc finger motif required for dosage compensation and a myosin- like putative ATP- binding region required for her-1 regulation of sex determination; SDC-3 activates dosage compensation by directing the dosage compensation protein complex to the hermaphrodite X chromosomes, and is functionally redundant with SDC-2 with respect to dosage compensation; SDC-1, SDC-2, and SDC-3 proteins form a complex. C25D7.4 C25D7.4 Protein containing a DUF38 domain of unknown function and an F-box domain, which serve as a link between a target protein and a ubiquitin-conjugating enzyme, has low similarity to C. elegans FOG-2, which is required for the sexual identity of germ cells This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins; this gene's encoded protein also contains an FTH/DUF38 motif, which may also mediate protein-protein interaction. C25D7.5 C25D7.5 Protein of unknown function, has weak similarity to C. elegans C03F11.2 C25D7.6 C25D7.6 Protein with high similarity to minichromosome maintenance deficient 3 (human MCM3), which associates with the DNA polymerase alpha-primase complex and is involved in initiation of DNA replication, member of the MCM family of DNA-dependent ATPases DNA replication licensing factor MCM3; mcm-3 encodes a member of the MCM2/3/5 family with similarity to human DNA replication licensing factor, MCM3, and affects embryonic viability. C25D7.7 C25D7.7 Protein with high similarity to human RAP2B, which translocates to the cytoskeleton in platelets stimulated with von Willebrand factor (human VWF), member of the Ras superfamily of GTP binding proteins RAS-related protein; rap-2 encodes a Ras-related GTPase that is most similar to the RAP2 members of the Ras GTPase superfamily; by homology, RAP-2 is predicted to function as a membrane-localized GTPase that likely plays a role in signal transduction; as animals homozygous for a rap-2 deletion mutation show no obvious abnormalities, the precise role of RAP-2 in C. elegans development and/or behavior is not yet known. C25D7.8 C25D7.8 Protein of unknown function, has low similarity to uncharacterized human FLJ20113 C25D7.9 C25D7.9 Protein of unknown function C25E10.1 C25E10.1 Protein containing a nuclear hormone receptor C4-type zinc finger domain, which bind DNA and may be involved in regulation of transcription, has low similarity to C. elegans NHR-84 zinc finger-containing protein C25E10.10 C25E10.10 Protein containing a trypsin inhibitor-like cysteine rich domain C25E10.11 C25E10.11 Protein of unknown function C25E10.12 C25E10.12 Protein of unknown function, has high similarity to uncharacterized C. elegans K07C11.7 C25E10.2 C25E10.2 Member of the cytochrome P450 family, has low similarity to cytochrome P450 2c29 (mouse Cyp2c29), which is a major cannabinoid metabolizing enzyme in liver microsomes and is involved in detoxification of xenobiotics and drugs cytochrome P450 C25E10.3 C25E10.3 Protein of unknown function, has high similarity to uncharacterized C. elegans C25E10.5 7TM chemoreceptor, srsx family C25E10.4 C25E10.4 Protein of unknown function, has high similarity to uncharacterized C. elegans C25E10.5 C25E10.5 C25E10.5 Protein of unknown function, has high similarity to uncharacterized C. elegans C25E10.4 C25E10.6 C25E10.6 Protein of unknown function C25E10.7 C25E10.7 Protein containing two trypsin inhibitor-like cysteine rich domains, has high similarity to uncharacterized C. elegans C25E10.8 C25E10.8 C25E10.8 Protein containing two trypsin inhibitor-like cysteine rich domains, has high similarity to uncharacterized C. elegans C25E10.9 C25E10.9 C25E10.9 Protein containing two trypsin inhibitor-like cysteine rich domains, has high similarity to uncharacterized C. elegans C25E10.8 C25F6.1 C25F6.1 Protein of unknown function C25F6.2 dlg-1;C25F6.2 Putative guanylate kinase required for adherens junctions assembly; strongly similar to D. melanogaster DLG1 (discs large 1) guanylate kinase; dlg-1 encodes a MAGUK protein, orthologous to Drosophila disks large, that is physically located to adherens junctions in all epithelia and that is genetically required for organization of the embryonic gut epithelium into an coherent tube. C25F6.3 C25F6.3 Protein with high similarity to dihydropyrimidine dehydrogenase (rat Dpyd), member of the pyridine nucleotide-disulphide oxidoreductase and dihydroorotate dehydrogenase families, contains two iron-sulfur cluster (4Fe-4S) binding domains The C25F6.3 gene encodes an ortholog of the human gene DIHYDROPYRIMIDINE DEHYDROGENASE (DPYD), which when mutated leads to thymine-uraciluria (OMIM:274270). C25F6.4 C25F6.4 Protein containing two protein kinase domains and an a F5 or 8 type C (discoidin) domain, has low similarity to discoidin domain receptor 2 (human DDR2), which is a receptor protein tyrosine kinase that is activated by collagen and upregulates human MMP1 Protein tyrosine kinase; The C25F6.4 gene encodes a protein tyrosine kinase homolog that is also homologous to human RS1. C25F6.6 C25F6.6 Protein of unknown function, has weak similarity to C. elegans M153.3 C25F6.7 C25F6.7 Protein of unknown function C25F9.1 C25F9.1 Putative ortholog of C. elegans Y116F11.Z gene product 7TM chemoreceptor, srw family C25F9.2 C25F9.2 Putative ortholog of C. elegans Y116F11.Y gene product C25F9.4 C25F9.4 Protein of unknown function, has strong similarity to uncharacterized C. elegans M04C3.2 C25F9.5 C25F9.5 Protein with high similarity to uncharacterized C. elegans M04C3.1, contains an SNF2 related N-terminal domain C25F9.6 C25F9.6 Protein with strong similarity to C. elegans Y116F11.V gene product C25F9.7 C25F9.7 Member of the rhodopsin family of G protein-coupled receptors (GPCR) 7TM chemoreceptor, srw family C25F9.8 C25F9.8 Putative ortholog of C. elegans F28B1.6 gene product C25F9.9 C25F9.9 Protein of unknown function, has low similarity to uncharacterized C. elegans Y43F8B.12 C25G4.1 C25G4.1 Member of the C-type lectin family Lectin C-type domain short and long forms (2 domains) C25G4.10 C25G4.10 Protein containing five fibronectin type III domains, which are involved in cell surface binding, three DB module domains, and an immunoglobulin (Ig) domain, has very strong similarity to uncharacterized C. elegans T04A11.3 fibronectin C25G4.11 C25G4.11 Protein of unknown function C25G4.2 C25G4.2 Protein of unknown function, has moderate similarity to uncharacterized human OVCA2, which is a candidate tumor suppressor that is downregulated in most ovarian tumors and tumor cell lines dihydrofolate reductase like C25G4.3 C25G4.3 Member of the ribosome-binding factor A family C25G4.4 C25G4.4 Protein containing an AT-hook motif, which preferentially binds A-T rich DNA, contains a SAND (Sp100, AIRE-1, NucP41/75 and DEAF-1/suppressin) domain, has weak similarity to a region of glucocorticoid modulatory element binding protein 1 (mouse Gmeb1) SAND domain C25G4.5 dpy-26;C25G4.5 Negative regulator of X-linked, dosage-compensated genes SDC-1, SDC-2, and SDC-3 proteins form a complex (detectable by coimmunoprecipitation); these three proteins, in turn, colocalize with DPY-26, DPY-27, and MIX-1 proteins both on a transgenic her-1(+) array and on the X chromosome. C25G4.6 C25G4.6 Protein containing two PDZ, DHR, or GLGF domains, which are found in signaling proteins, has very strong similarity to uncharacterized C. elegans T21G5.4 PDZ domain (Also known as DHR or GLGF). (2 domains) C25G4.7 C25G4.7 Protein of unknown function, has high similarity to uncharacterized C. elegans ZK973.8 C25G4.8 C25G4.8 Protein of unknown function, has high similarity to uncharacterized C. elegans Y49F6B.8 C25G6.1 C25G6.1 Protein with moderate similarity to C. elegans F35D11.1 gene product C25G6.2 C25G6.2 Member of the tetraspanin family, which contain an N-terminal transmembrane domain that is a signal sequence and membrane anchor, has low similarity to motility related protein 1 (CD9 antigen, human CD9), which mediates platelet activation and aggregation transpanin C25G6.3 C25G6.3 Member of the AMP-binding enzyme family luciferase C25G6.4 C25G6.4 Protein of unknown function C25G6.5 C25G6.5 Member of the rhodopsin family of G protein-coupled receptors (GPCR), has low similarity to neuropeptide Y-Y1 receptor (human NPY1R), which inhibits adenylyl cyclase and induces calcium flux and is associated with a wide variety of physiological processes G-protein coupled receptor (family 1) C25H3.1 C25H3.1 Putative casein kinase, has similarity to human, S. cerevisiae, and D. melanogaster casein kinases C25H3.10 C25H3.10 Protein containing an F-box domain, which serve as a link between a target protein and a ubiquitin-conjugating enzyme C25H3.11 C25H3.11 Protein with strong similarity to C. elegans T08G11.1 gene product C25H3.12 C25H3.12 Protein of unknown function C25H3.3 C25H3.3 Protein containing one uncharacterized bacterial PaaI domain C25H3.4 C25H3.4 Protein of unknown function, has low similarity to uncharacterized ligatin (human LGTN), which is a putative receptor for phosphoglycoproteins that may be involved in intracellular protein trafficking C25H3.5 C25H3.5 Protein of unknown function C25H3.6 C25H3.6 Protein of unknown function C25H3.7 C25H3.7 Protein containing a glutathione S-transferase C-terminal domain, which may be involved in conjugation of reduced glutathione to various targets C25H3.9 C25H3.9 Protein with strong similarity to S. cerevisiae Vps13p, a nonessential protein involved in vacuolar sorting C26B2.1 C26B2.1 Protein with low similarity to dynactin 4 (human DCTN4), which is a component of the dynactin complex that directly binds actin-related protein 1 (human ACTR1A) and may be involved in human ACTR1A pointed end capping C26B2.2 C26B2.2 Protein of unknown function, has strong similarity to C. elegans ZK930.7 C26B2.3 nhr-31;nhr-21;C26B2.3 Member of the nuclear hormone receptor/zinc finger protein family zinc finger protein C26B2.4 C26B2.4 Protein containing a nuclear hormone receptor ligand binding domain and a nuclear hormone receptor C-4 type zinc finger domain, has weak similarity to nuclear receptor 2F1 (human NR2F1), which regulates transcription and activates HIV gene transcription nuclear hormone receptor C26B2.5 C26B2.5 Protein of unknown function C26B2.6 C26B2.6 Protein of unknown function, has low similarity to uncharacterized human FLJ20498 C26B2.7 C26B2.7 Protein of unknown function C26B2.8 C26B2.8 Protein of unknown function, has weak similarity to C. elegans ZC84.6 C26B9.1 C26B9.1 Protein of unknown function C26B9.2 C26B9.2 Protein with strong similarity to C. elegans F35D2.2 gene product C26B9.3 C26B9.3 Protein of unknown function C26B9.5 C26B9.5 Protein with weak similarity to prolylcarboxypeptidase (angiotensinase C, human PRCP), which is a serine carboxypeptidase that catalyzes the cleavage of C-terminal amino acid residues linked to proline lysosomal Pro-X carboxypeptidase C26B9.6 C26B9.6 Protein containing a C3HC4 type (RING) zinc finger, which may mediate protein-protein interactions, and two WWE domains, which may mediate protein interactions in ubiquitin and ADP ribose conjugation systems C26B9.7 C26B9.7 Protein of unknown function C26C6.1 C26C6.1 Protein containing two high mobility group box (HMG1 or 2) family domains, ten bromodomains, which interact specifically with acetylated lysine, four C2H2 type zinc finger domains, which bind nucleic acids, and four bromo-adjacent homology (BAH) domains HMG (high mobility group) box, Bromodomain (5 domains), Zinc finger, C2H2 type; C26C6.1 encodes an ortholog of the vertebrate Polybromo proteins (e.g., human BAF180; OMIM:606083); C26C6.1 has multiple domains associated with transcriptional regulation (bromodomains, zinc-finger domains, a 'high mobility group' / HMG domain) and a glutamine/asparagine-rich domain. C26C6.2 goa-1;C26C6.2 Member of the G protein alpha subunit protein family; apparently involved in synaptic transmission; may have a role in regulating centrosome movement during early embryogenesis guanine nucleotide-binding protein; The goa-1 gene encodes an ortholog of the heterotrimeric G protein alpha subunit Go (Go/Gi class) that affects normal locomotion, egg-laying, and male mating; it genetically interacts with the egl-30 pathway, and is expressed in all neurons and sex-specific muscles. C26C6.3 C26C6.3 Member of the astacin (M12A) family of metalloproteases, contains a CUB domain and a type 1 thrombospondin domain, has low similarity to C. elegans HCH-1, which is a putative zinc-dependent metalloprotease zinc metalloprotease C26C6.4 C26C6.4 Protein of unknown function, has high similarity to uncharacterized C. elegans F28G4.4 C26C6.5 C26C6.5 Protein of unknown function C26C6.6 C26C6.6 Protein containing two LIM domains, which may mediate protein-protein interactions, has low similarity to a region of leupaxin (human LPXN), which is a putative signal transduction protein that binds focal adhesion protein tyrosine kinase PYK2 (PTK2B) lim domains C26C6.7 C26C6.7 Protein of unknown function, has weak similarity to C. elegans C18C4.8 Globin C26C6.8 C26C6.8 Protein containing a Src homology 3 (SH3) domain, which bind proline-rich peptides tyrosine-protein kinase like C26D10.1 C26D10.1 Protein containing six regulator of chromosome condensation (RCC1) repeat domains, has low similarity to regulator of chromosome condensation 1 (human CHC1), which binds chromatin and functions as a guanine nucleotide exchange factor for human RAN regulator of chromosome condensation C26D10.2 hel-1;hel;C26D10.2 Protein with high similarity to S. cerevisiae Sub2p, which is an essential pre-mRNA splicing factor, member of the DEAD or DEAH box ATP-dependent RNA helicase family and contains a helicase conserved C-terminal domain translation initiation factor eIF-4A C26D10.3 C26D10.3 Member of the pyridine nucleotide-disulphide oxidoreductase family, which are flavoproteins, has low similarity to uncharacterized human FLJ22028 oxidoreductase C26D10.4 C26D10.4 Putative ortholog of C. elegans C26D10.5 gene product C26D10.5 C26D10.5;EFF-1 Protein of unknown function, has low similarity to uncharacterized C. elegans C44B7.3 The eff-1 gene encodes a novel, type I transmembrane glycoprotein that is required for cell fusion during development; eff-1(hy21) mutants are viable, but have severe body morphology defects associated with cell fusion failure. C26D10.6 C26D10.6 Protein of unknown function C26E1.1 C26E1.1 Protein of unknown function C26E1.2 C26E1.2 Protein of unknown function, has weak similarity to human atrophin-1 related protein (DRPLA) C26E1.3 C26E1.3 Protein of unknown function C26E6.1 C26E6.1 Protein of unknown function, has low similarity to uncharacterized C. elegans C50H2.7 C26E6.11 C26E6.11 Member of the DUF80 family of unknown function C26E6.12 C26E6.12 Protein with strong similarity to C. elegans M01E5.2 gene product C26E6.2 C26E6.2 Protein with strong similarity to C. elegans Y11D7A.12 gene product C26E6.3 C26E6.3 Putative ortholog of S. cerevisiae Ynl288p, a protein of unknown function cell differentiation family, Rcd1-like C26E6.4 C26E6.4 Protein with high similarity to RNA polymerase II polypeptide b (human POLR2B), which is the second largest RNA polymerase II subunit that regulates some transcriptional coactivators including human BRCA1, member of the RNA polymerases beta subunit family DNA-directed RNA polymerase II C26E6.5 C26E6.5 Protein with strong similarity to C. elegans Y46E12BL.4 gene product C26E6.6 C26E6.6 Protein with weak similarity to ribosomal protein L3 Ribosomal protein L3; This gene encodes a protein predicted by Eisenberg and coworkers, with 52% accuracy, to be mitochondrial. C26E6.7 C26E6.7 Protein of unknown function C26E6.8 ula-1;C26E6.8 Putative NED-8 activating enzyme; ortholog of human amyloid beta precursor protein-binding protein 1 (APPBP1), a protein possibly involved in onset of Alzheimer's Disease The ula-1 gene encodes a component of the enzyme that activates NED-8, which in turn is a ubiquitin-like protein whose conjugating enzyme is UBC-12. C26E6.9 set-2;C26E6.9 Protein containing three SET domains, which are involved in protein-protein interactions, and two RNA recognition motifs (RRM, RBD, or RNP), has a region of moderate similarity to a region of S. cerevisiae Set1p, which mediates methylation of histone H3 C26F1.1 C26F1.1 Protein of unknown function C26F1.10 C26F1.10 Protein of unknown function flp-21 encodes a single FMRFamide-related neuropeptide (FaRP) that serves as a ligand for NPR-1, a G protein-coupled receptor that regulates social versus solitary feeding behavior in several Caenorhabditis species; genetic analysis suggests that FLP-21 acts through NPR-1 to inhibit social feeding behavior; FLP-21 is expressed in the ADL, ASE and ASH sensory neurons, the URA motor neurons, the MC, M2 and M4 pharyngeal neurons, and the intestine; flp-21 encodes the only FMRFamide-related neuropeptide (FaRP) encoded by the C. elegans genome that activates both the social (215F) and the solitary (215V) forms of NPR-1 in both Xenopus oocytes and pharyngeal assays. C26F1.2 C26F1.2 Member of the cytochrome P450 family, has low similarity to cytochrome P450 subfamily 4F polypeptide 6 (rat Rn.11269), which may be one of the major forms of P450 to catalyze the NADPH-dependent omega hydroxylation of fatty acids in the brain cytochrome P450 C26F1.3 C26F1.3;5I259 Protein of unknown function C26F1.4 C26F1.4 Member of the ubiquitin family, has high similarity to uncharacterized finkel-Biskis-Reilly murine sarcoma virus ribosomal protein S30 (human FAU), which is a ubiquitin-like protein formed by fusion of the genes for ribosomal protein S30 ribosomal protein/ubiquitin-like protein; rps-30 encodes two proteins, a small ribosomal subunit S30 protein and ubiquitin, which is cleaved from the ribosomal protein posttranslationally; by homology, S30 is predicted to function in protein biosynthesis and ubiquitin in protein degradation; in C. elegans, loss of rps-30 function via RNA-mediated interference (RNAi) does not result in any obvious abnormalities. C26F1.5 C26F1.5 Protein of unknown function containing a Ground-like domain, has weak similarity to C. elegans T02E9.2 C26F1.6 C26F1.6 Member of the rhodopsin family of G protein-coupled receptors (GPCR), has low similarity to neuromedin U receptor 2 (human NMU2R), which increases levels of intracellular calcium and may play a role in sensory transmission or modulation and feeding C26F1.6 encodes a homolog of the functionally active Fmrf Receptor (FR; CG2114) of D. melanogaster; it is thus possible that C26F1.6 is a receptor for one of the FMRF-like neurotransmitters in C. elegans (e.g., FLP-1 through FLP-12). C26F1.7 C26F1.7 Protein containing an N-terminal HIT (histidine triad) domain, has weak similarity over HIT domains to protein kinase C inhibitors including human HINT C26F1.9 C26F1.9;5I256 Protein with high similarity to ribosomal protein L39 (S. cerevisiae Rpl39p), which is a structural ribosomal protein, contains a ribosomal L39 domain, which are present in the large ribosomal subunit ribosomal protein L39; rpl-39 encodes a large ribosomal subunit L39 protein. C26G2.1 C26G2.1 Member of the immunoglobulin-like protein family Immunoglobulin domain ; Fibronectin type III domain; The gene C26G2.1 encodes an ortholog of human NEPHRIN (NPHS1; OMIM:602716), which when mutated leads to congenital nephrotic syndrome 1 (OMIM:256300). C26G2.2 C26G2.2 Protein with weak similarity to C. elegans F35C5.3 gene product C26G2.3 slt-1;F40E10.4;C26G2.3 Protein containing 18 leucine rich repeat, 1 extracellular laminin G, 7 epidermal growth factor (EGF)-like, 4 leucine rich repeat N-terminal cysteine rich and 4 leucine rich repeat C-terminal cysteine rich domains, has moderate similarity to human SLIT2 C26H9A.1 vha-7;C26H9A.B;C26H9A.1 Member of the vacuolar H+-ATPase protein family C26H9A.A C26H9A.2;C26H9A.A Protein of unknown function C27A12.2 C27A12.2 Protein containing seven C2H2 type zinc finger domains, which bind nucleic acids, has weak similarity to zinc finger protein 255 (human ZNF255), which is a DNA-binding Kruppel-like zinc finger protein that positively regulates transcription zinc finger protein C27A12.3 C27A12.3 Protein containing six C2H2 type zinc finger domains, which bind nucleic acids, has low similarity to human ZNF146, which binds DNA, zinc, and heparin and may be involved in development or progression of pancreatic carcinomas zinc finger protein C27A12.4 C27A12.4 Protein of unknown function, has weak similarity to C. elegans F34D10.4 C27A12.5 ceh-2;C27A12.5 Protein containing a homeobox domain (homeodomain), which are found in transcription factors, has a region of high similarity to a region of empty spiracles homolog 2 (human EMX2), which may play a role in cerebral cortex development and schizencephaly homeobox protein; ceh-2 encodes a homeodomain protein homologous to Drosophila empty spiracles (EMS) and the vertebrate EMX1 and EMX2 proteins (OMIM:600034, 600035); although the exact biological role of CEH-2 in C. elegans development and/or behavior is not yet known, expression in pharyngeal neurons and muscle, as well as vulval cells (vulB1, vulB2, and vulC) at late stages of development suggests that CEH-2 may play a role in terminal differentiation events in diverse cell types. C27A12.6 C27A12.6 Member of the TRIAD family of zinc finger proteins C27A12.7 C27A12.7 Member of the Ykr017p-like protein family C27A12.8 C27A12.8 Member of the TRIAD family of zinc finger proteins C27A12.9 C27A12.9 Protein containing a type I phosphodiesterase or nucleotide pyrophosphatase domain, has low similarity to phosphatidylinositol glycan class O (mouse Pigo), which plays a role in glycosylphosphatidylinositol (GPI) anchor biosynthesis C27A2.1 C27A2.1 Putative coiled-coil protein, has similarity to members of the S. pombe SMC (structural maintenance of chromosomes) family C27A2.2 C27A2.2 Protein with high similarity to ribosomal protein L22 (human RPL22), which binds heparin and relocalizes with viral RNA in Epstein-Barr virus infected B-lymphocytes, member of the ribosomal L22e family, which are part of the large ribosomal subunit ribosomal protein L22; rpl-22 encodes a large ribosomal subunit L22 protein; by homology, RPL-22 is predicted to function in protein biosynthesis; in C. elegans, RPL-22 activity is broadly required for embryonic and germline development, as well as normal body coloration, morphology, and postembryonic growth rates. C27A2.3 C27A2.3 Protein of unknown function C27A2.4 C27A2.4 Member of the acid phosphatase protein family acid phosphotase C27A2.5 C27A2.5 Protein of unknown function, has high similarity to uncharacterized C. elegans C04G6.7 C27A2.6 C27A2.6 Possibly involved in WNT signalling; contains putative DAX, PDZ, and DEP domains similar to D. melanogaster Dishevelled dsh-2 encodes a protein containing a DIX domain, a DEP domain, and a PDZ domain that is required for embryonic viability and functions in Wnt pathway signaling between the embryonic blastomeres P2 and EMS with respect to endoderm specification and to orient the division axis of the EMS cell; expressed from the four-cell embryo stage, and is primarily associated with membranes. C27A7.1 C27A7.1 Protein containing a type I phosphodiesterase or nucleotide pyrophosphatase domain, has low similarity to ectonucleotide pyrophosphatase-phosphodiesterase 1 (human ENPP1), which is upregulated in fibroblasts of patients with non-insulin-dependent diabetes Human plasma-cell membrane glycoprotein PC-1 like; C27A7.1 is orthologous to the human gene NPPASE (ENPP1; OMIM:173335), which when mutated leads to disease. C27A7.2 C27A7.2 Protein containing a DUF23 domain of unknown function, has high similarity to uncharacterized C. elegans T22D1.1 C27A7.3 C27A7.3 Protein containing a type I phosphodiesterase or nucleotide pyrophosphatase domain, has low similarity to human ENPP1, which is a membrane ectonucleotide pyrophosphatase-phosphodiesterase Human plasma-cell membrane glycoprotein PC-1 like C27A7.4 che-11;C27A7.4 Required for normal cilial development, dauer larva formation, and chemotaxis towards water-soluble chemicals che-11 encodes a large, unfamiliar protein with orthologs in vertebrates and arthropods (e.g., KIAA0590 and CG11838-PA) and in Chlamydomonas (IFT140), as well as distant similarity to OSM-1 and ZK520.1; che-11 is required for normal synthesis of sensory cilia (via intraflagellar transport) in sensory neurons, osmotic avoidance, and dauer formation. C27A7.5 C27A7.5 Member of the asparaginase or glutaminase family, which deaminate asparagine or glutamine, contains six ankyrin (Ank) repeats, has moderate similarity to large form lysophospholipase (rat Rn.29979), which also has asparaginase activity Asparaginase ; Ank repeat C27A7.6 C27A7.6 Member of an uncharacterized protein family C27A7.7 C27A7.7 Member of the 7-transmembrane chemoreceptor family of G protein-coupled receptors (GPCR), has low similarity to C. elegans ODR-10, which is involved in odorant response C27B7.1 spr-2;C27B7.1 Protein with strong similarity to human and D. melanogaster SET proteins, suppressor of presenilin SET protein; spr-2 encodes the C. elegans ortholog of the Drosophila and mammalian SET proteins (OMIM:600960, translocation breakpoint in human SET is associated with acute myeloid leukemia); SPR-2 is predicted to be a member of the SET protein complex that functions in chromatin remodeling, DNA repair, and transcriptional regulation; in C. elegans, SPR-2 may function to regulate the activity and/or levels of the presenilin proteins encoded by sel-12 and hop-1, as mutations in spr-2 suppress mutations in sel-12 in a hop-1-dependent manner; spr-2 is detected in the nuclei of all cells at several developmental stages, including the L3 larval stage. C27B7.2 C27B7.2 Protein of unknown function C27B7.4 C27B7.4 Protein containing a helicase conserved C-terminal domain and two SNF2 related N-terminal domains, has low similarity to a region of X-linked nuclear protein (human XNP), which may be a transcriptional regulator that functions in DNA repair DNA repair protein C27B7.5 C27B7.5 Protein containing a zinc knuckle domain, which can bind eukaryotic RNA or DNA Zinc finger, CCHC class C27B7.6 C27B7.6 Member of the protein phosphatase protein family serine/threonine protein phosphatase C27B7.7 C27B7.7 Protein containing seven fibronectin type III domains, which are involved in cell surface binding, and an immunoglobulin (Ig) domain, which may be involved in protein interactions, has weak similarity to a region of C. elegans DIG-1 fibronectin type-III repeats C27B7.8 C27B7.8;rrp-1 Protein with strong similarity to ras related protein 1b (human RAP1B), which is involved in cell cycle progression, cellular proliferation and possibly cAMP-responsive tumorigenesis, member of the Ras superfamily of GTP binding proteins ras protein; rap-1 encodes a member of the Ras superfamily of small GTPases; the activated protein interacts with W05B10.4 and T14G10.2 in yeast two-hybrid assays and rap-1 is expressed in some neurons in the head and tail, the rectal epithelial cells, body muscle, hypodermis, and in the somatic cells of the gonad. C27C12.1 C27C12.1 Protein with moderate similarity to C. elegans R107.6 gene product C27C12.2 C27C12.2 Protein containing three C2H2 type zinc finger domains, which bind nucleic acids, has a region of high similarity to a region of early growth response 1 (human EGR1), which is an early response protein induced by a wide variety of stimuli Zinc finger, C2H2 type (3 domains); C27C12.2 is orthologous to the human gene BA436D10.3 (EARLY GROWTH RESPONSE 2 (KROX-20 (DROSOPHILA) HOMOLOG)) (EGR2; OMIM:129010), which when mutated leads to disease. C27C12.3 C27C12.3 Protein of unknown function, has high similarity to uncharacterized C. elegans F31F6.1 member of worm-specific protein family C27C12.4 C27C12.4 Protein of unknown function, has low similarity to uncharacterized human ET C27C12.5 C27C12.5 Member of the amiloride-sensitive sodium channel family, which are involved in sodium reabsorption, has low similarity to a region of C. elegans FLR-1, which is a membrane protein that confers wild-type sensitivity to fluoride C27C12.6 C27C12.6 Protein containing one DM (dsx and mab-3) DNA binding domain doublesex protein like C27C12.7 C27C12.7 Member of the prolyl oligopeptidase family, contains a dipeptidyl peptidase IV N-terminal domain, has low similarity to fibroblast activation protein (mouse Fap), which is a serine protease that may be involved in cell proliferation and embryogenesis dipeptidyl aminopeptidase like C27C7.1 C27C7.1 Protein of unknown function, has high similarity to uncharacterized C. elegans H11L12.1 C27C7.2 C27C7.2 Protein with strong similarity to C. elegans ZK1025.4 gene product C27C7.3 nhr-74;C27C7.3 Member of the zinc finger protein family with similarity to nuclear hormone receptors nuclear hormone receptor C27C7.4 nhr-73;C27C7.4 Member of the zinc finger protein family with similarity to nuclear hormone receptors Zinc finger, C4 type (two domains) C27C7.5 C27C7.5 Member of the galectin family, which are lectins that bind beta galactosides, has moderate similarity to uncharacterized C. elegans T02G6.7 C27C7.7 C27C7.7 Protein of unknown function, has low similarity to uncharacterized C. elegans PES-10 C27C7.8 C27C7.8 Protein containing a nuclear hormone receptor ligand-binding domain, has high similarity to uncharacterized C. elegans ZK1025.6 C27D11.1 egl-45;C27D11.1 Putative large subunit of translation initiation factor eIF3 egl-45 encodes a homolog of eukaryotic translation initiation factor 3, subunit 10, that affects development of the HSNs that affect egg laying. C27D6.1 C27D6.1 Putative coiled-coil protein, has weak similarity to myosin heavy chains C27D6.10 srb-1;C27D6.10 G protein-coupled receptor; member of a subfamily with SRB proteins, which are expressed in chemosensory neurons; no homolog found in human or D. melanogaster 7TM chemoreceptor, srb family C27D6.3 C27D6.3 Protein of unknown function, has high similarity to uncharacterized C. elegans F11G11.4 MST101-2 protein (Fruit Fly) C27D6.4 C27D6.4 Protein containing a bZIP (basic-leucine zipper) transcription factor domain, has a region of moderate similarity to a region of cAMP responsive element binding protein 3 (human CREB3), which is a transcription factor that binds human HCFC1 BZIP protein C27D6.5 C27D6.5 Protein with strong similarity to C. elegans C34F11.7 gene product C27D6.6 srb-5;C27D6.6 G protein-coupled receptor; member of a subfamily with SRB proteins, which are expressed in chemosensory neurons; no homolog found in human or D. melanogaster 7TM chemoreceptor, srb family C27D6.7 srb-4;C27D6.7 G protein-coupled receptor; member of a subfamily with SRB proteins, which are expressed in chemosensory neurons; no homolog found in human or D. melanogaster C27D6.8 srb-3;C27D6.8 G protein-coupled receptor; member of a subfamily with SRB proteins, which are expressed in chemosensory neurons; no homolog found in human or D. melanogaster 7TM chemoreceptor, srb family C27D6.9 srb-2;C27D6.9 G protein-coupled receptor; member of a subfamily with SRB proteins, which are expressed in chemosensory neurons; no homolog found in human or D. melanogaster 7TM chemoreceptor, srb family C27D8.1 C27D8.1 Protein containing a protein kinase domain, has low similarity to casein kinase 1 epsilon (mouse Csnk1e), which is a putative serine-threonine protein kinase with broad substrate specificity that may act in DNA repair and regulation of circadian rhythm serine/threonine kinase C27D8.2 C27D8.2 Protein of unknown function C27D8.3 C27D8.3 Protein of unknown function, has moderate similarity to uncharacterized C. elegans T12G3.2 The C27D8.3 gene encodes a protein that may be involved in apoptosis. C27D8.4 C27D8.4 Protein of unknown function, has weak similarity to C. elegans C01G8.3 C27D8.5 C27D8.5 Putative ortholog of C. elegans T23B5.3 gene product C27D9.1 C27D9.1 Protein of unknown function, has low similarity to uncharacterized C. elegans F53C3.11 C27D9.2 C27D9.2 Protein of unknown function, has moderate similarity to uncharacterized C. elegans F26G1.3 C27F2.1 C27F2.1 Protein with weak similarity to C. elegans C51G7.C gene product C27F2.10 C27F2.10 Protein of unknown function C27F2.2 C27F2.2 Member of the ion transport family, which include calcium, sodium, and potassium channels, has weak similarity to voltage-dependent L-type calcium channel (rat Cacna1c), which is a pore-forming subunit of a dihydropyridine-sensitive calcium channel calcium channel subunit; nca-2 encodes a four-domain, voltage-gated ion channel; NCA-2 is required for normal rates of movement and may function with NCA-1, another voltage-gated ion channel, to regulate locomotion; NCA-2 is expressed in the nerve ring, ventral cord motorneurons, and a subset of tail neurons. C27F2.4 C27F2.4 Protein of unknown function, has high similarity to uncharacterized S. pombe Spac26a3.06p Methyltransferase C27F2.5 C27F2.5 Protein with high similarity to human EAP30, which is a subunit of the ELL transcription elongation factor complex that binds to and derepresses the RNA polymerase II inhibitory activity of ELL S. cerevisiae Snf8p C27F2.6 C27F2.6 Putative ortholog of C. elegans twk-5 gene product C27F2.7 C27F2.7 Protein of unknown function, has weak similarity to S. cerevisiae Yol072p and Yjr084p This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins. C27F2.8 C27F2.8 Protein of unknown function, has weak similarity to uncharacterized mouse Rw1 C27F2.9 C27F2.9 Protein of unknown function C27H2.1 C27H2.1 Putative transposase C27H2.2 C27H2.2 Protein of unknown function C27H2.3 C27H2.3 Protein with similarity at the N-terminus of human Hs.169638 protein, DIFF40 protein C27H5.1 C27H5.1 Protein of unknown function, has high similarity to uncharacterized cGMP phosphodiesterase delta subunit (human PDE6D) C27H5.2 C27H5.2 Protein of unknown function, has weak similarity to uncharacterized C. elegans F46H5.7 C27H5.3 C27H5.3 Member of the zinc finger in Ran binding proteins family, which may be involved in nuclear transport, contains an RNA recognition motif Probable RNA binding protein C27H5.4 C27H5.4 Protein of unknown function, has low similarity to uncharacterized C. elegans F28B3.5 C27H5.5 col-36;C27H5.5 Collagen of the COL-6 family of collagens; has strong similarity to D. melanogaster Cg25C gene product cuticular collagen; col-36 encodes a collagen protein; expressed during the L1 to L2 and L2 to dauer larval stage molts. C27H5.6 C27H5.6 Protein with moderate similarity to C. elegans R02D5.6 gene product C27H5.7 C27H5.7 Protein of unknown function C27H5.8 C27H5.8 Protein containing neurotransmitter-gated ion-channel ligand binding and transmembrane domains, has moderate similarity to C. elegans GLC-1, which is an alpha subunit of avermectin-sensitive glutamate-gated chloride channel GluCl ligand-gated ionic channel; glc-4 encodes a predicted glutamate-gated chloride channel that affects ivermectin sensitivity and reversal behavior and genetically interacts with avr-14; expressed in neurons. C27H6.1 C27H6.1 Member of the clathrin adaptor complexes medium chain family, which are involved in transport of clathrin-coated vesicles, has a region of low similarity to a region of stoned B/TFIIA alpha/beta like factor (human SALF) Adaptor complexes medium subunit family; apt-10 encodes the C. elegans ortholog of the mammalian Stonins and Drosophila Stoned B, membrane-associated proteins that contain three distinct domains: a proline-rich domain, a stonin homology domain, and a domain paralogous to the mu-adaptin subunits of adaptor protein complexes 1-3; by homology, APT-10 is predicted to regulate the activity of the heteromeric AP-1 and AP-2 clathrin adaptor protein complexes, and thus to play a role in intracellular protein trafficking and endocytosis; in vivo, apt-10 is required for the secretion of EGL-17/FGF, required for sex myoblast migration, from the vulval precursor cell P6. | apt-10 encodes the C. elegans ortholog of the mammalian Stonins and Drosophila Stoned B, membrane-associated proteins that contain three distinct domains: a proline-rich domain, a stonin homology domain, and a domain paralogous to the mu-adaptin subunits of adaptor protein complexes 1-3; by homology, APT-10 is predicted to regulate the activity of the heteromeric AP-1 and AP-2 clathrin adaptor protein complexes, and thus to play a role in intracellular protein trafficking and endocytosis; in vivo, apt-10 is required for the secretion of EGL-17/FGF, required for sex myoblast migration, from the vulval precursor cell P6.p; loss of apt-10 activity via large-scale RNAi screens, however, does not result in any obvious abnormalities. C27H6.2 C27H6.2 Member of a protein family Yeast hypothetical 50.5 KD protein like C27H6.3 C27H6.3 Protein of unknown function, has weak similarity to C. elegans F36H12.2 C27H6.4 C27H6.4 Protein of unknown function, has high similarity to uncharacterized C. elegans R13H9.1 C28A5.1 C28A5.1 Protein of unknown function, has strong similarity to uncharacterized C. elegans C28A5.2 C28A5.2 C28A5.2 Protein of unknown function, has strong similarity to uncharacterized C. elegans C28A5.1 C28A5.3 nex-3;C28A5.3 Member of the annexin family, which exhibit calcium-dependent phospholipid binding, has moderate similarity to annexin V (human ANXA5), which is a calcium-dependent phospholipid-binding protein that inhibits phospholipase A2 activity Annexin; nex-3 encodes an annexin, a member of a family of calcium-dependent phospholipid binding proteins; by homology, NEX-3 could function in a number of processes, such as membrane fusion, cytoskeletal interactions, and intracellular signaling; however, as loss of nex-3 function via RNA-mediated interference (RNAi) does not result in any abnormalities, the precise role of NEX-3 in C. elegans development and/or behavior is not yet known. C28A5.4 ceh-43;C28A5.4 Homeodomain transcription factor required for the development of the anterior hypodermis, has similarity to D. melanogaster DLL (Distal-less) and human DLX5 homeodomain transcription factors homeobox protein (distal-less subfamily); A homeobox protein of the Distal-less (Dll) class that is required for development of the anterior hypdermis during embryonic morphogenesis for cell adhesion; also affects embryonic and larval viability; it is predominantly expressed in the head hypdodermis, neuronal support cells and CAN neurons. C28A5.5 C28A5.5 Protein of unknown function C28A5.6 C28A5.6 Putative ortholog of C. elegans K09C6.1 gene product serine/threonine kinase C28C12.1 C28C12.1 Protein of unknown function C28C12.10 C28C12.10 Protein with moderate similarity over the middle region to H. sapiens FGD1 gene product [faciogenital dysplasia] C28C12.11 C28C12.11 Protein of unknown function C28C12.12 C28C12.12 Protein of unknown function C28C12.13 C28C12.13 Putative ortholog of C. elegans C33A12.14 gene product 7TM chemoreceptor, sru family C28C12.2 C28C12.2 Protein of unknown function C28C12.3 C28C12.3 Protein containing a DUF148 domain of unknown function, has high similarity to uncharacterized C. elegans T05E11.8 C28C12.4 C28C12.4 Protein containing a DUF148 domain of unknown function, has high similarity to uncharacterized C. elegans ZK596.1 C28C12.5 C28C12.5 Protein with strong similarity to C. elegans C28C12.7 gene product C28C12.6 C28C12.6 Protein with moderate similarity to C. elegans C28C12.5 gene product C28C12.7 C28C12.7 Protein with strong similarity to C. elegans C28C12.5 gene product spp-10 encodes two protein isoforms that are orthologous to the human gene PROSAPOSIN (PSAP; OMIM:176801, mutated in Gaucher disease and metachromatic leukodystrophy); SPP-10A and -10B are predicted to have 3 and 4 embedded saposin sequences, that are likely to be split into individual saposin peptides by proteolysis; in mammals, saposins activate the enzymes sphingomyelinphosphodiesterase and beta-glucosylceramidase; spp-10 has no obvious function in mass RNAi assays. C28C12.8 C28C12.8 Protein containing one helix-loop-helix DNA-binding domain, which mediate protein dimerization C28C12.9 C28C12.9 Protein with weak similarity to very-long-chain acyl-coenzyme A dehydrogenase (rat Acadvl), which is a rate-controlling enzyme in beta-oxidation of long-chain fatty acids gei-9 encodes a protein containing a putative acyl-CoA dehydrogenase domain; interacts with GEX-3 in yeast two-hybrid assays. C28D4.1 C28D4.1 Protein containing nuclear hormone receptor C4-type zinc finger and ligand-binding domains, has weak similarity to hepatic nuclear factor 4 (mouse Hnf4), which regulates liver-specific gene expression and is involved in metabolism and development Ligand-binding domain of nuclear hormone receptors, Zinc finger, C4 type C28D4.2 C28D4.2 Member of the choline or ethanolamine kinase family, which catalyze the formation of phosphatidylcholine by the CDP-choline pathway, has moderate similarity to choline-ethanolamine kinase (rat Chkl), which is involved in phosphatidylcholine biosynthesis choline kinase C28D4.3 C28D4.3 Protein with high similarity to glutamine synthase (rat Glul), which catalyzes the condensation of glutamate and ammonia to form glutamine and may clear L-glutamate from neuronal synapses, contains one glutamine synthetase domain glutamine synthase C28D4.4 C28D4.4 Protein of unknown function, has high similarity to uncharacterized C. elegans C28D4.5 C28D4.5 C28D4.5 Protein of unknown function, has high similarity to uncharacterized C. elegans C28D4.4 C28D4.7 C28D4.7 Putative ortholog of C. elegans C28D4.4 gene product C28D4.8 C28D4.8 Putative ortholog of C. elegans C28D4.4 gene product C28D4.9 C28D4.9 Putative ortholog of C. elegans C28D4.1 gene product Ligand-binding domain of nuclear hormone receptors, Zinc finger, C4 type C28F5.1 C28F5.1 Protein of unknown function C28F5.2 C28F5.2 Protein with moderate similarity to C. elegans W01C9.5 gene product C28F5.3 C28F5.3 Protein of unknown function C28F5.4 C28F5.4 Member of the insulinase (peptidase M16) family, has low similarity to insulin-degrading enzyme (insulysin, rat Ide), which degrades insulin, amyloid beta (rat App), insulin-like growth factors, amylin (rat Iapp), and natriuretic peptides insulinase; This gene encodes a protein predicted by Eisenberg and coworkers, with 68% accuracy, to be mitochondrial. C28F5.5 C28F5.5 TcA transposase transposase C28G1.1 C28G1.1 Member of the ubiquitin-conjugating enzyme (E2) family, has a region of moderate similarity to a region of huntingtin interacting protein 2 (human HIP2), which is a ubiquitin-conjugating enzyme that interacts with huntingtin (human HD) ubiquitin-conjugating enzyme; ubc-23 encodes a predicted conjugating enzyme (UBCs/E2s) of the ubiquitin-conjugation system; expressed in larvae and adults in cells around the pharynx and in intestinal cells. C28G1.2 C28G1.2 Predicted member of the serpin superfamily and a member of the Heat Shock (HS47) family of serpins according to sequence similarity heat shock 47k protein C28G1.3 C28G1.3 Protein of unknown function GTP-binding protein and M protein C28G1.4 C28G1.4 Protein containing five C2H2 type zinc finger domains, which bind nucleic acids zinc finger C28G1.5 C28G1.5 Protein with strong similarity to C. elegans ZK1240.3 gene product C28H8.1 C28H8.1 Protein of unknown function C28H8.1 is orthologous to the human gene BCL7A (OMIM:601406), which when mutated leads to high-grade B-cell non-Hodgkin lymphoma. C28H8.11 C28H8.11 Putative tryptophan 2,3-dioxygenase tryptophan 2,3-dioxygenase C28H8.12 dnc-2;C28H8.12 Predicted component of dynactin complex; dynamitin dnc-2 encodes a member of the dynamitin family that affects spindle alignment in polarized cells in early embryos, nuclear movement, spindle morphology, chromosome segregation, and pronuclear migration. C28H8.2 C28H8.2 Protein of unknown function C28H8.3 C28H8.3 Member of the DEAD or DEAH box ATP-dependent RNA helicase family and contains a helicase conserved C-terminal domain, has a region of weak similarity to a region of human SKIV2L, which is an ATP-dependent RNA helicase C28H8.4 C28H8.4 Member of an uncharacterized protein family ER lumen protein retaining receptor C28H8.5 C28H8.5 Protein of unknown function, has high similarity to uncharacterized C. elegans C15F1.1 C28H8.6 C28H8.6 Protein with high similarity to transforming growth factor beta 1 induced transcript 1 (rat Tgfb1i1), which is a steroid receptor co-activator and focal adhesion protein that inhibits heat shock protein Hsp27, contains four LIM domains LIM domains C28H8.7 C28H8.7 Protein of unknown function, has weak similarity to C. elegans F20D6.2 C28H8.8 C28H8.8 Member of the domain of unknown function DUF13 family, has low similarity to uncharacterized C. elegans C33G8.13 C28H8.9 C28H8.9 Protein containing two PHD-fingers, which may be involved in chromatin-mediated transcriptional regulation, and a C2H2 type zinc finger domain, has a region of moderate similarity to a region of zinc finger protein 220 (human ZNF220) C29A12.1 C29A12.1 Protein of unknown function C29A12.2 C29A12.2 Putative ortholog of C. elegans T10C6.9 gene product C29A12.3 C29A12.3 Contains one ATP-dependent DNA ligase domain, has moderate similarity to S. pombe Cdc17p, which is a DNA ligase required for DNA replication and repair DNA ligase I; lig-1 is orthologous to the human gene LIM HOMEOBOX PROTEIN 3 ISOFORM B (LIG1; OMIM:600577), which when mutated leads to disease. C29A12.4 C29A12.4 Protein containing 4 extracellular laminin G domains and 2 epidermal growth factor (EGF)-like domains, has a region of weak similarity to neurexin 4 (contactin associated protein 1, human CNTNAP1), which is a neuronal paranodal transmembrane receptor neurexin I like C29A12.6 C29A12.6 Protein containing a von Willebrand factor (vWF) type A domain C29E4.1 C29E4.1 Protein containing two collagen triple helix repeats, which are found in some extracellular proteins, and a nematode cuticle collagen N-terminal domain, has low similarity to C. elegans SQT-1, which is a collagen Cuticle collagen C29E4.10 C29E4.10 Protein of unknown function C29E4.10 is orthologous to the human gene GALACTOCEREBROSIDASE (GALC; OMIM:606890), which when mutated leads to disease. C29E4.11 C29E4.11 Putative ortholog of C. elegans C29E4.9 gene product C29E4.2 C29E4.2 Protein of unknown function, has weak similarity to human pathogen Entamoeba histolytica myosin heavy chain C29E4.4 C29E4.4 Protein of unknown function C29E4.7 C29E4.7 Protein containing glutathione S-transferase N-terminal and C-terminal domains, has low similarity to glutathione-S-transferase like (human GSTTLp28), which has thiol transferase and dehydroascorbate reductase activities and modulates ryanodine receptors C29E4.8 C29E4.8 Member of the adenylate kinase protein family Adenylate kinase; This gene encodes a protein predicted by Eisenberg and coworkers, with 52% accuracy, to be mitochondrial. C29E4.9 C29E4.9 Putative ortholog of C. elegans C29E4.11 gene product C29E6.1 let-653;C29E6.1 Putative mucin-like protein required for development beyond the late L1 larval stage or early L2 larval stage LET-653 mucin like protein; let-653 encodes a mucin-like protein similar to the highly glycosylated mucins secreted by the apical surface of epithelia and believed to provide a protective barrier to exposed cellular surfaces; LET-653 is required for viability, locomotion, and for maintaining the tubular epithelial structure of the excretory cell canals. C29E6.2 C29E6.2 Member of the ion transport family, which include calcium, sodium, and potassium channels, contains 16 ankyrin (Ank) repeats, has a region of low similarity to a region of ankyrin 1 (human ANK1), which is a cytoskeletal anchor protein ankyrin repeats C29E6.3 C29E6.3 Member of the protein-tyrosine phosphatase family, which are involved in control of cell growth, proliferation, differentiation and transformation, has strong similarity to uncharacterized C. elegans ZK809.1 protein tyrosine phosphatase C29E6.4 C29E6.4 Member of a protein family C29E6.5 C29E6.5 Protein containing a nuclear hormone receptor C4-type zinc finger domain, which bind DNA and may be involved in regulation of transcription, has a region of low similarity to a region of retinoic acid receptor gamma (mouse Rarg) Zinc finger, C4 type (two domains) C29E6.6 C29E6.6 Member of the transposase family, which are required for excising and inserting mobile genetic elements, has very strong similarity to uncharacterized C. elegans C31A11.2 transposase C29F3.1 C29F3.1 Protein with high similarity to human HADHA, which is a mitochondrial long-chain enoyl-CoA hydratase and 3-hydroxyacyl-CoA dehydrogenase, contains 3-hydroxyacyl-CoA dehydrogenase C-terminal and NAD binding domains long-chain enoyl-CoA hydratase C29F3.2 wrt-8;C29F3.2 Has strong similarity to C. elegans WRT-4, a protein of unknown function Hint module C29F3.3 C29F3.3 Protein of unknown function, has high similarity to uncharacterized C. elegans ZK512.7 C29F3.4 C29F3.4 Member of the C-type lectin family Lectin C-type domain C29F3.5 C29F3.5 Member of the C-type lectin family Lectin C-type domain C29F3.6 C29F3.6 Member of the rhodopsin family of G protein-coupled receptors (GPCR), has moderate similarity to uncharacterized C. elegans K07C6.9 7 transmembrane receptor (rhodopsin family) C29F3.7 C29F3.7 Protein containing a DUF141 domain of unknown function, has moderate similarity to uncharacterized C. elegans ZK1037.6 C29F4.1 C29F4.1 Protein with high similarity to C. elegans DPY-16, contains two collagen triple helix repeats, which are found in some extracellular proteins, and a nematode cuticle collagen N-terminal domain collagen C29F4.2 C29F4.2 Member of the C. elegans putative membrane protein family 8, has a region of moderate similarity to a region of bestrophin (human VMD2), which plays a role in vision and causes Bests disease, adult vitelliform macular dystrophy, and bull's eye maculopathy Putative membrane protein C29F4.3 C29F4.3 Protein of unknown function C29F5.1 C29F5.1 Protein of unknown function C29F5.2 C29F5.2 Protein of unknown function, has low similarity to uncharacterized C. elegans F36H12.14 C29F5.3 C29F5.3 Protein of unknown function C29F5.4 C29F5.4 Protein of unknown function, has weak similarity to a member of the C. elegans EGF-like domain protein family (T13C2.4) C29F5.5 C29F5.5 Protein with strong similarity to C. elegans C29F5.2 gene product C29F5.6 C29F5.6 Member of the reverse transcriptase protein family, which are RNA-dependent DNA polymerases, has strong similarity to uncharacterized C. elegans F31A9.6 Reverse transcriptase C29F5.7 C29F5.7 Member of the globin family of oxygen transporters C29F7.1 C29F7.1 Protein containing a DUF227 domain of unknown function, has high similarity to uncharacterized C. elegans C29F7.2 C29F7.2 C29F7.2 Protein containing a DUF227 domain of unknown function, has high similarity to uncharacterized C. elegans C29F7.1 C29F7.3 C29F7.3 Protein with high similarity to UMP-CMP kinase (human UMP-CMPK), which phosphorylates nucleotide and deoxynucleotide phosphates and chemotherapeutic deoxycytidine analogs, member of the adenylate kinase family uridylate kinase; This gene encodes a protein predicted by Eisenberg and coworkers, with 52% accuracy, to be mitochondrial. C29F7.4 C29F7.4 Protein containing a fork head domain, which are found in transcription factors involved in cell fate determination, has a region of high similarity to a region of forkhead box C2 (mouse Foxc2), which is a transcriptional activator fork head domain protein C29F7.5 C29F7.5 Protein containing a fork head domain, which are found in transcription factors involved in cell fate determination, has a region of high similarity to a region of forkhead box C2 (mouse Foxc2), which is a transcriptional activator fork head domain protein; fkh-4 encodes a member of the forkhead domain transcription factor family. C29F7.6 C29F7.6 Protein containing a Jumonji (jmjC) domain, has low similarity to uncharacterized C. elegans F23D12.5 C29F7.7 C29F7.7 Protein of unknown function, has weak similarity to C. elegans F23D12.3 C29F9.1 C29F9.1 Protein of unknown function, has weak similarity to C. elegans Y119D3_456.C C29F9.10 C29F9.10 Protein containing two DUF38 domains of unknown function, has low similarity to uncharacterized C. elegans ZC47.6 C29F9.11 C29F9.11 Protein containing two F-box domains, which serve as a link between a target protein and a ubiquitin-conjugating enzyme, and a DUF38 domain of unknown function, has low similarity to C. elegans FOG-2, which is required for sexual identity of germ cells C29F9.12 C29F9.12 Protein of unknown function, has weak similarity to C. elegans F22D3.5 C29F9.13 C29F9.13 Protein containing a nuclear hormone receptor ligand-binding domain C29F9.14 C29F9.14 Protein with weak similarity to C. elegans C29F9.1 gene product C29F9.2 C29F9.2;3A339 Protein of unknown function, has weak similarity to C. elegans F17B5.1 C29F9.3 C29F9.3 Protein of unknown function, has weak similarity to uncharacterized C. elegans T17A3.2 C29F9.4 C29F9.4 Protein of unknown function C29F9.5 C29F9.5 Protein containing a transcriptional adaptor putative zinc finger (TAZ) domain, which may bind transcriptional activators and repressors, has low similarity to a region of C. elegans CBP-1, which is a transcriptional activator C29F9.6 C29F9.6 Protein containing a transcriptional adaptor putative zinc finger (TAZ) domain, which may bind transcriptional activators and repressors, has a region of high similarity to a region of E1A binding protein p300 (human EP300) C29F9.7 pat-4;ilk;C29F9.7 Strongly similar to human ILK; required for embryonic development and muscle structure integrin-linked kinase; The pat-4 gene encodes a serine/threonine kinase orthologous to human integrin-linked kinase (ILK, OMIM:602366) and is required for formation of integrin-mediated muscle cell attachments during embryogenesis; PAT-4 probably functions as an adaptor molecule and localizes to dense bodies and M lines; PAT-4 forms a ternary complex with PAT-6/actopaxin and UNC-112, and requires UNC-112, UNC-52/perlecan, PAT-2/alpha integrin, and PAT-3/beta integrin for proper localization to newly forming integrin adhesion complexes. C29F9.8 C29F9.8 Putative ortholog of C. elegans C29F9.9 gene product C29F9.9 C29F9.9 Putative ortholog of C. elegans C29F9.8 gene product C29G2.1 C29G2.1 Protein with moderate similarity to C. elegans R02D3.7 gene product C29G2.2 C29G2.2 Protein of unknown function C29G2.3 C29G2.3 Protein of unknown function C29G2.4 C29G2.4 Protein containing a DUF32 domain of unknown function, has high similarity to uncharacterized C. elegans Y45G12C.5 7TM chemoreceptor, srt family C29G2.5 C29G2.5 Protein containing a nuclear hormone receptor C4-type zinc finger domain, which bind DNA and may be involved in transcription regulation, has a region of moderate similarity to a region of C. elegans NHR-80, which acts in embryogenesis and morphogenesis 7TM chemoreceptor, srt family C29G2.6 C29G2.6 Protein with moderate similarity to C. elegans F07F6.5 gene product C29H12.1 C29H12.1 Member of the class I arginyl (R) tRNA synthetase family, has low similarity to S. cerevisiae Ydr341p, which is a cytoplasmic arginine-tRNA synthetase arginyl-tRNA synthetase C29H12.2 C29H12.2 Protein of unknown function, has high similarity to uncharacterized human FLJ20555 C29H12.3 rgs-3;C29H12.3 Protein containing two regulator of G protein signaling domains, has a region of moderate similarity to a region of regulator of G protein signaling 8 (rat Rgs8), which acts as a GTPase activating protein selective for Gi-Go alpha subunits 1R20 protein (Human); rgs-3 encodes a protein with two highly similar RGS domains with highest similarity to human RGS8. C29H12.5 C29H12.5 Protein containing a Chromo domain, which bind chromatin C29H12.6 C29H12.6 Protein of unknown function C30A5.1 C02F5.7;C30A5.1 Protein with high similarity to F box leucine rich repeat 3 (human FBXL2), which is a putative subunit of the SCF ubiquitin ligase involved in protein degradation, contains a leucine rich repeat and two F-box domains C30A5.10 C30A5.10 Protein of unknown function, putative paralog of C. elegans C30A5.6 C30A5.2 C30A5.2 Protein of unknown function, has weak similarity to human RAD51L3, a putative homolog of S. cerevisiae Rad51p rfs-1 encodes a RAD51-like protein, orthologous to mammalian RAD-51C, that is related to bacterial recA, a multifunctional enzyme involved in DNA repair, homologous recombination, and induction of the SOS response; RFS-1 has no obvious function in mass RNAi assays; however, RFS-1 can interact with RAD-51, a C. elegans RAD51 homolog involved in meiosis and DNA repair, suggesting that RFS-1 may also play a role in these processes. C30A5.3 C30A5.3 Protein of unknown function, has high similarity to uncharacterized mouse Prei3 C30A5.4 C30A5.4 Member of the protein phosphatase protein family C30A5.5 C30A5.5 Member of the synaptobrevin family, which are intrinsic membrane proteins found in small synaptic vesicles, has strong similarity to uncharacterized C. elegans T14D7.3 snb-5 encodes a predicted synaptobrevin. C30A5.6 C30A5.6 Protein of unknown function C30A5.7 unc-86;C30A5.7 POU domain homeodomain transcription factor required for the production and differentiation of assorted neurons, has similarity over 160 amino acids to D. melanogaster VVL (ventral veins lacking) homeodomain transcription factor Pou homeodomain; unc-86 encodes a transcription factor with a POU-type homeodomain that is required for correct fate determination and differentiaion in diverse neuronal lineages, including those of egg-laying neurons, mechanosensory neurons, and chemosensory interneurons; UNC-86 is orthologous to human BRN-3; UNC-86 is required for tph-1 and cat-1 expression in specific serotonergic neurons, as well as for neurite outgrowth. C30A5.9 C30A5.9 Protein with strong similarity to C. elegans Y61A9LA.N gene product transposase C30B5.1 C30B5.1 Protein with moderate similarity to C. elegans ZK154.5 gene product C30B5.2 C30B5.2 Protein of unknown function C30B5.3 cpb-2;C30B5.3 Protein with low similarity to C. elegans CPB-1, which is involved in spermatogenesis and male meiosis C. elegans protein C40H1.1; The cbp-2 gene encodes a cytoplasmic polyadenylation element binding (CPEB) protein homolog, expressed specifically in the spermatogenic germ line. C30B5.4 C30B5.4 Protein containing an RNA recognition motif (RRM, RBD, or RNP), has a region of high similarity to S. cerevisiae Ist3p, which is involved in splicing, spliceosome assembly, and possibly sodium tolerance Probable RNA binding protein C30B5.5 C30B5.5 Protein with moderate similarity to C. elegans F57A8.4 gene product C30B5.6 C30B5.6 Protein of unknown function C30B5.7 C30B5.7 Protein with strong similarity to C. elegans F09C12.6 gene product C30C11.1 C30C11.1 Protein of unknown function C30C11.2 rpn-3;C30C11.2 Protein containing a PCI (proteasome, COP9-complex and eIF3 ) or PINT (Proteasome, Int-6, Nip-1 and TRIP-15) domain, which are found in multi-protein complexes, has low similarity to S. cerevisiae Rpn33p, which is a component of the 26S proteasome complex Diphenol oxidase A2 C30C11.4 C30C11.4 Member of the Hsp70 family, which are stress-induced protein chaperones, has moderate similarity to 105 kDa heat shock protein (human HSP105B), which has expression induced by heat shock and increased in cancer cells Msi3p C30D11.1 unc-103;nerg;C30D11.1 Putative eag-like potassium channel potassium channel protein; unc-103 encodes an ERG-like K+ channel homolog, orthologous to human KCNH6 (OMIM:608168); UNC-103 regulates muscle activation in motility, egg-laying and male spicule protraction; UNC-103 is expressed highly in many neurons; gain-of-function alleles can be uncoordinated, while loss-of-function alleles have a more subtle defect in copulatory spicule protraction. C30D11.2 C30D11.2 Protein of unknown function C30E1.2 C30E1.2 Protein of unknown function, has high similarity to uncharacterized C. elegans C08A9.3 C30E1.3 C30E1.3 Protein of unknown function, has high similarity to uncharacterized C. elegans C08A9.4 C30E1.4 C30E1.4 Protein of unknown function, has moderate similarity to uncharacterized C. elegans C08A9.5 C30E1.5 C30E1.5 Protein with moderate similarity to C. elegans F30B5.5 gene product C30E1.6 C30E1.6 Protein of unknown function, has moderate similarity to uncharacterized C. elegans C08A9.3 C30E1.7 C30E1.7 Protein with strong similarity to C. elegans Y37H2C.1 gene product C30E1.8 C30E1.8 Protein of unknown function, has moderate similarity to uncharacterized C. elegans F11D11.3 C30F12.1 C30F12.1 Protein of unknown function C30F12.2 C30F12.2 Putative ortholog of S. cerevisiae Afg1p, a protein of unknown function C30F12.3 C30F12.3 Protein of unknown function C30F12.4 C30F12.4 Protein of unknown function C30F12.5 C30F12.5 Protein of unknown function C30F12.6 C30F12.6 Member of the rhodopsin family of G protein-coupled receptors (GPCR), has moderate similarity to thyrotropin-releasing hormone receptor (human TRHR), which mediates the release of thyroid stimulating hormone and prolactin (human PRL) seven trans-membrane receptor C30F12.7 C30F12.7 Protein with high similarity to C. elegans F35G12.2, which is involved in gametogenesis, larval development, and embryogenesis or morphogenesis, member of the isocitrate and isopropylmalate dehydrogenase family isocitrate dehydrogenase C30F2.1 C30F2.1 Protein containing two collagen triple helix repeats, which are found in some extracellular proteins, and a nematode cuticle collagen N-terminal domain, has a region of moderate similarity to a region of C. elegans BLI-1 collagen C30F2.2 C30F2.2 Protein of unknown function, has weak similarity to C. elegans C53A5.6 Zinc finger, C3HC4 type (RING finger) C30F2.3 C30F2.3 Protein of unknown function C30F8.2 C30F8.2 Protein of unknown function vaculolar ATPase C30F8.3 C30F8.3 Protein of unknown function C30F8.4 C30F8.4 Protein with strong similarity to C. elegans abl-1 gene product protein kinase; kin-32 encodes an ortholog of human focal adhesion kinase (FAK1; Q05397; OMIM:600758), also known as cytoplasmic protein-tyrosine kinase (PTK2). C30G12.1 C30G12.1 Protein of unknown function, has weak similarity to C. elegans R01E6.2 C30G12.2 C30G12.2 Member of the short-chain dehydrogenase-reductase family, which are NAD- or NADP-dependent oxidoreductases, has low similarity to rat Cbr, which is a broad-specificity NADPH-dependent oxidoreductase Alcohol dehydrogenase C30G12.3 C30G12.3 Protein of unknown function C30G12.4 C30G12.4 Protein containing one DUF225 domain of unknown function C30G12.5 C30G12.5 Protein of unknown function C30G12.6 C30G12.6 Protein of unknown function C30G12.7 puf-8;C30G12.7 Protein containing eight Pumilio-family (Puf) RNA binding domains, has moderate similarity to a region of S. cerevisiae Puf3p, which is involved in metabolism of S. cerevisiae COX17 mRNA C30G4.1 C30G4.1 Member of the transposase family, which are required for excising and inserting mobile genetic elements, has very strong similarity to uncharacterized C. elegans F27B3.4 transposase C30G4.2 C30G4.2 Protein of unknown function C30G4.3 gcy-11;C30G4.3 Putative guanylyl cyclase guanylate cyclase receptor C30G4.4 C30G4.4 Protein of unknown function C30G4.5 C30G4.5 Protein of unknown function C30G4.6 C30G4.6 Protein containing a DUF41 domain of unknown function C30G4.7 C30G4.7 Protein with weak similarity to C. elegans Y48C3A.12 gene product C30G7.1 C30G7.1 Member of the histone H1 and H5 family of linker histones, has low similarity to the 21.5 kDa form of histone H1 (C. elegans HIS-24), which plays a role in gonad and germ cell development and in chromatin silencing histone H1 like C30H6.1 C30H6.1 Protein with strong similarity to C. elegans C49C3.13, a member of the C-type lectin family Lectin C-type domain short and long forms C30H6.2 C30H6.2 Member of the ZIP zinc transporter family, which may be metal transporters tag-141/C30H6.2 encodes a putative zinc transporter orthologous to human SLC39A4 (OMIM:607059, mutated in acrodermatitis enteropathica). C30H6.3 C30H6.3 Protein containing a C-type lectin domain, which mediate calcium-dependent carbohydrate recognition C30H6.4 C30H6.4 Member of the C-type lectin family, has similarity to human fibroblast chondroitin sulfate proteoglycan core protein, which has lectin-like properties Lectin C-type domain short and long forms C30H6.5 C30H6.5 Protein of unknown function C30H6.6 C30H6.6 Member of the ABC transporter family, which are involved in translocation across biological membranes, contains an ABC transporter transmembrane domain, has moderate similarity to S. cerevisiae Mdl1p, which is involved in mitochondrial peptide release multidrug resistance protein (p-glycoprotein); haf-1 encodes a predicted transmembrane protein of the ATP-binding cassette (ABC) transporter superfamily; by homology, HAF-1 is proposed to function in ATP-dependent transport of molecules across plasma and intracellular membranes; however, as loss of HAF-1 function via RNA-mediated interference (RNAi) does not result in any abnormalities, the precise role of HAF-1 in C. elegans development and/or behavior is not yet known. C30H6.7 C30H6.7 Protein containing a 2-oxo acid dehydrogenases acyltransferase catalytic domain and an E3 binding domain, has moderate similarity to a region of dihydrolipoamide dehydrogenase-binding protein (protein X, human PDX1) 2-oxo acid dehydrogenases acyltransferase (catalytic domain); This gene encodes a protein predicted by Eisenberg and coworkers, with 68% accuracy, to be mitochondrial. C30H6.8 C30H6.8 Member of the thioredoxin family, has moderate similarity to C. elegans R05H5.3, which is involved in embryogenesis or morphogenesis Thioredoxins C30H6.9 C30H6.9 Protein of unknown function C30H7.2 C30H7.2 Member of the thioredoxin family, has low similarity to glucose regulated 58kDa protein human (GRP58), which acts as a protein disulfide isomerase involved in folding and maturation of N-linked glycoproteins and MHC class I antigen processing C31A11.1 C31A11.1 Member of the uncharacterized protein family UPF0063, has high similarity to uncharacterized C. elegans C31A11.5 C31A11.2 C31A11.2 Member of the transposase family, which are required for excising and inserting mobile genetic elements, has very strong similarity to uncharacterized C. elegans F47G9.5 Transposase C31A11.3 C31A11.3 Protein containing two DUF40 domains of unknown function, which contain four conserved cysteines, has low similarity to uncharacterized C. elegans C02A12.5 7TM receptor, srbc family C31A11.4 C31A11.4 Protein containing a DUF40 domain of unknown function, which contain four conserved cysteines, has high similarity to uncharacterized C. elegans M01B2.3 7TM receptor, srbc family C31A11.5 C31A11.5 Member of the uncharacterized protein family UPF0063, has high similarity to uncharacterized C. elegans C31A11.1 C31A11.6 C31A11.6 Protein of unknown function, has high similarity to uncharacterized C. elegans W07A8.5 C31A11.7 C31A11.7 Member of the uncharacterized protein family UPF0063, has high similarity to uncharacterized C. elegans C31A11.5 C31A11.8 C31A11.8 TcA transposase Tc1 transposase C31A11.9 C31A11.9 Member of the 7-transmembrane chemoreceptor family of G protein-coupled receptors (GPCR), has low similarity to C. elegans ODR-10, which is involved in odorant response C31B8.1 C31B8.1 Protein with moderate similarity to C. elegans F59B1.6 gene product C31B8.11 C31B8.11 Protein of unknown function, has strong similarity to uncharacterized C. elegans SRH-37 7TM chemoreceptor, srh family C31B8.12 C31B8.12 Member of the domain of unknown function DUF13 family, has high similarity to uncharacterized C. elegans Y82E9BL.12 C31B8.13 C31B8.13 Member of the 7-transmembrane chemoreceptor family of G protein-coupled receptors (GPCR), has high similarity to uncharacterized C. elegans H05B21.2 7TM chemoreceptor, srh family C31B8.2 C31B8.2 Protein with moderate similarity to C. elegans F47G4.1 gene product C31B8.4 C31B8.4 Protein of unknown function, has weak similarity to uncharacterized C. elegans C17H1.3 C31B8.6 C31B8.6 Member of the 7-transmembrane chemoreceptor family of G protein-coupled receptors (GPCR), has low similarity to C. elegans ODR-10, which is involved in odorant response 7TM chemoreceptor, str family C31B8.7 C31B8.7 Protein containing a DUF138 domain of unknown function, has high similarity to uncharacterized C. elegans T06A1.5 C31B8.8 C31B8.8 Putative matrix metalloprotease C31B8.9 C31B8.9 Protein of unknown function, has high similarity to uncharacterized C. elegans K06H6.5 C31C9.1 C31C9.1 Protein of unknown function apical gut membrane protein C31C9.2 C31C9.2 Protein containing a D-isomer specific 2-hydroxyacid dehydrogenase catalytic domain and a D-isomer specific 2-hydroxyacid dehydrogenase NAD binding domain, has low similarity to human GRHPR, which is a glyoxylate reductase-hydroxypyruvate reductase D-3-Phosphoglycerate dehydrogenase; C31C9.2 is orthologous to the human gene PHOSPHOGLYCERATE DEHYDROGENASE (PHGDH; OMIM:606879), which when mutated leads to phosphoglycerate dehydrogenase deficiency. C31C9.3 C31C9.3 Protein containing a DUF38 domain of unknown function and an F-box domain, which serve as a link between a target protein and a ubiquitin-conjugating enzyme, has low similarity to C. elegans T07D3.1, which may act in germ-line stem cell differentiation This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins; this gene's encoded protein also contains an FTH/DUF38 motif, which may also mediate protein-protein interaction. C31C9.4 C31C9.4 Protein containing two DUF38 domains of unknown function and two F-box domains, which serve as a link between a target protein and a ubiquitin-conjugating enzyme This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins; this gene's encoded protein also contains an FTH/DUF38 motif, which may also mediate protein-protein interaction. C31C9.5 C31C9.5 Member of the reverse transcriptase protein family, which are RNA-dependent DNA polymerases, has high similarity to uncharacterized C. elegans ZK1320.8 reverse transcriptase; This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins. C31E10.1 C31E10.1 Member of the 7-transmembrane chemoreceptor family of G protein-coupled receptors (GPCR), has moderate similarity to uncharacterized C. elegans R08C7.7 C31E10.2 C31E10.2 Putative ortholog of C. elegans K02A2.6 gene product reverse transcriptase C31E10.3 C31E10.3 Protein containing a DUF41 domain of unknown function, has low similarity to uncharacterized C. elegans Y46H3D.4 C31E10.4 C31E10.4 Protein of unknown function, has weak similarity to C. elegans Y18D10A.R C31E10.5 C31E10.5 Protein of unknown function, has weak similarity to uncharacterized C. elegans C16A11.2 C31E10.6 C31E10.6 Protein of unknown function, has weak similarity to uncharacterized C. elegans C16A11.2 C31E10.7 C31E10.7 Protein containing a heme-binding domain, has moderate similarity to cytochrome b5 (S. cerevisiae Cyb5p), which is likely to play a role in sterol metabolism cytochrome b5; C31E10.7 is orthologous to the human gene UNKNOWN (PROTEIN FOR MGC:10230) (CYB5; OMIM:250790), which when mutated leads to disease. C31E10.8 C31E10.8 Protein containing a TBC domain, which may be GTPase activators of Rab-like small GTPases, has a region of low similarity to a region of mouse Vrp S.pombe protein C4G8.04 like C31G12.1 C31G12.1 Protein of unknown function, has strong similarity to uncharacterized C. elegans W04E12.2 C31G12.2 C31G12.2 Member of the C-type lectin family Lectin C-type domain short and long forms C31G12.3 C31G12.3 Protein of unknown function C31G12.4 C31G12.4 Protein containing an F-box domain, which serve as a link between a target protein and a ubiquitin-conjugating enzyme C31H1.1 C31H1.1 Protein of unknown function, has moderate similarity to uncharacterized C. elegans T25B9.6 C31H1.2 C31H1.2 Protein of unknown function C31H1.3 C31H1.3 Putative ortholog of C. elegans F14F9.6 gene product C31H1.5 C31H1.5 Protein with moderate similarity to C. elegans F35C11.5 gene product C31H1.6 C31H1.6 Protein of unknown function, has low similarity to uncharacterized C. elegans B0001.1 C31H1.7 C31H1.7 Protein of unknown function C31H1.8 C31H1.8 Protein of unknown function C31H2.1 C31H2.1 Protein containing a TBC domain, which may be GTPase activators of Rab-like small GTPases C31H2.2 C31H2.2 Protein containing a collagen triple helix repeats, which are found in some extracellular proteins, and a nematode cuticle collagen N-terminal domain, has a region of moderate similarity to C. elegans DPY-7, which is a cuticle collagen collagen alpha (weak); dpy-8 encodes a collagen with a nematode-specific N-terminal domain that is required for normal body morphology and (perhaps) for a normal embryonic cell division rate; dpy-8 interacts genetically with emb-5 and glp-1. C31H2.3 C31H2.3 Protein of unknown function 4-hydroxyphenylpyruvate dioxygenase (4HPPD) C31H2.4 C31H2.4 Protein with moderate similarity to 4-hydroxyphenylpyruvate dioxygenase (rat Hpd), which is an enzyme of tyrosine catabolism C31H2.4 is orthologous to human 4-HYDROXYPHENYLPYRUVATE DIOXYGENASE (HPD; OMIM:276710), which when mutated leads to tyrosinemia type III; C31H2.4 is somewhat less similar to human HPD than C. elegans HPD-1 (to which C31H2.4 is paralogous). C31H5.1 C31H5.1 Protein of unknown function, has high similarity to uncharacterized C. elegans F35H12.5 C31H5.3 acr-19;C31H5.3 Protein containing neurotransmitter-gated ion-channel ligand binding and transmembrane domains, has moderate similarity to alpha 7 subunit of the neuronal nicotinic acetylcholine receptor (rat Chrna7), which plays a role in neurotransmission nicotinic acetylcholine receptor; acr-19 encodes a predicted member of the alpha subunit family of nicotinic acetylcholine receptors. C31H5.4 C31H5.4 Protein of unknown function C31H5.5 C31H5.5 Protein of unknown function C31H5.6 C31H5.6 Putative acyl-CoA thioesterase C32A3.1 sel-8;lag-3;C32A3.1 Glutamine rich protein that is a probably a transcription factor required for the normal function of the C. elegans glp-1 and lin-12 signaling pathways sel-8 encodes a nuclear protein required for LIN-12 and GLP-1 signalling; SEL-8 contains a novel motif shared with W09C5.1 and orthologs of W09C5.1 in S. cerevisiae (YER126c), Drosophila (DMIP259), and also has two prominent glutamine-rich domains. C32A3.2 C32A3.2 Protein of unknown function C32A3.3 C32A3.3 Protein with coiled coil domains, has similarity to D. melanogaster EG:132E8.4 protein coiled coil domains C32A9.1 C32A9.1 Protein of unknown function C32B5.1 C32B5.1 Putative ortholog of C. elegans F45D11_39.B gene product C32B5.10 C32B5.10 Protein containing an F-box domain, which serve as a link between a target protein and a ubiquitin-conjugating enzyme, has high similarity to uncharacterized C. elegans R07C3.8 C32B5.11 C32B5.11 Protein with moderate similarity to C. elegans C32B5.12 gene product C32B5.12 C32B5.12 Protein of unknown function, has low similarity to uncharacterized C. elegans F58H7.8 C32B5.13 C32B5.13 Member of the papain family of cysteine proteases, has low similarity to a region of cathepsin H (rat Ctsh), which is a cysteine (thiol) protease that is involved in a variety of proteolytic processes and is inhibited by stefins A and B C32B5.14 C32B5.14 Protein of unknown function, has low similarity to uncharacterized C. elegans C32B5.16 C32B5.15 C32B5.15 Protein containing an F-box domain, which serve as a link between a target protein and a ubiquitin-conjugating enzyme, has low similarity to uncharacterized C. elegans C39B5.2 This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins. C32B5.16 C32B5.16 Protein of unknown function, has low similarity to uncharacterized C. elegans C32B5.14 C32B5.2 C32B5.2 Member of the 7-transmembrane chemoreceptor family of G protein-coupled receptors (GPCR), has high similarity to uncharacterized C. elegans C03G6.7 7TM chemoreceptor, srh family C32B5.3 C32B5.3 Protein with strong similarity to C. elegans C32B5.16 gene product C32B5.4 C32B5.4 Protein of unknown function, has moderate similarity to uncharacterized C. elegans C32B5.16 C32B5.5 C32B5.5 Protein of unknown function, has low similarity to uncharacterized C. elegans C32B5.16 C32B5.6 C32B5.6 Protein of unknown function C32B5.7 C32B5.7 Member of the papain family of cysteine proteases, has moderate similarity to a region of cathepsin H (rat Ctsh), which is a cysteine (thiol) protease involved in a variety of proteolytic processes and is inhibited by stefins A and B cathepsin-like peptidase C32B5.8 C32B5.8 Protein of unknown function, has low similarity to uncharacterized C. elegans C32B5.16 C32B5.9 C32B5.9 Protein of unknown function, has low similarity to uncharacterized C. elegans C44C8.3 C32C4.1 nShab4;C32C4.1 Putative voltage-gated potassium channel potassium channel; This gene encodes a protein predicted by Eisenberg and coworkers, with 52% accuracy, to be mitochondrial. C32C4.2 C32C4.2 Protein with high similarity to C. elegans AQP-CE2, which is a mercury-sensitive water channel protein, member of the major intrinsic protein (MIP) family, which are transmembrane channels MIP protein C32C4.3 C32C4.3 Protein of unknown function C32D5.1 C32D5.1 Protein of unknown function, has weak similarity to C. elegans Y55F3A_747.J C32D5.10 C32D5.10 Protein containing a C3HC4 type (RING) zinc finger, which may mediate protein-protein interactions C32D5.11 C32D5.11 Protein containing a C3HC4 type (RING) zinc finger, which may mediate protein-protein interactions C32D5.12 C32D5.12 Protein containing an NAD-dependent epimerase/dehydratase domain and a 3-beta hydroxysteroid dehydrogenase/isomerase domain, has weak similarity to S. cerevisiae C-3 sterol dehydrogenase (Ygl001p) C32D5.2 sma-6;C32D5.2 Receptor serine/threonine protein kinase with similarity to human TGF-beta receptor and bone morphogenetic protein receptor, involved in body size regulation and male tail development Activin receptor C32D5.3 C32D5.3 Putative ortholog of human Hs.84087 gene product, protein KIAA0143 isolated from human cell line KG-1 cDNA library C32D5.4 C32D5.4 Protein of unknown function C32D5.5 C32D5.5 Protein of unknown function, has moderate similarity to uncharacterized human CGI-85 C32D5.6 C32D5.6 Protein containing a TPR (tetratrico peptide repeat) domain, which may mediateprotein-protein interactions, has moderate similarity to uncharacterized human DEME-6 C32D5.7 C32D5.7 Protein of unknown function C32D5.8 C32D5.8 Protein with high similarity to C. elegans RO5H5.3, which is involved in embryogenesis or morphogenesis, member of the thioredoxin family, which are small enzymes involved in redox reactions Thioredoxin C32D5.9 C32D5.9 Protein with high similarity to S. cerevisiae Aut7p, which is required for delivery of autophagic vesicles to the vacuole and for Cvt vesicle formation, member of the microtubule associated protein 1A or 1B light chain 3 family C32E12.1 C32E12.1 Putative coiled-coil protein, has weak similarity over the N-terminus to S. cerevisiae mRNA cap-binding protein Tif4632p C32E12.2 C32E12.2 Member of the 3',5'-cyclic nucleotide phosphodiesterase family, has moderate similarity to phosphodiesterase 11A (human PDE11A), which is a dual-substrate phosphodiesterase that hydrolyzes both cGMP and cAMP cyclic nucleotide phosphodiesterase C32E12.3 C32E12.3 Protein containing a high mobility group box (HMG1 or 2) family domain, has a region of high similarity to a region of SRY box 11 (human SOX11), which is a transcriptional activator that may serve in neural differentiation and retrotransposon regulation C32E12.4 C32E12.4 Protein with weak similarity to C. elegans nmy-2, which is a nonmuscle myosin II heavy chain-related protein required for cytokinesis and establishment of early embryonic polarity C32E8.1 C32E8.1 Protein containing a C3HC4 type (RING) zinc finger, which may mediate protein-protein interactions, has a region of moderate similarity to a region of ADP-ribosylation factor domain protein 1 (rat Arfd1), which is a GTPase C32E8.10 C32E8.10 Putative ortholog of C. elegans C32E8.10A gene product unc-11 encodes multiple isoforms of a clathrin-adaptor protein AP180 (OMIM:603025) that functions in clathrin-mediated endocytosis; UNC-11 is essential for embryogenesis, locomotion, and pharyngeal pumping, and regulates neurotransmitter release by controlling vesicle trafficking and fusion; UNC-11 is also required for localization of SNB-1/synaptobrevin to synaptic vesicles, thus acting as a sorting protein as well as a clathrin-adaptor protein; UNC-11 is expressed at high levels in nearly all neurons, where it is enriched at presynaptic terminals, and is also expressed in coelomocytes, the uv1 secretory cells of the vulva, and the intestine. C32E8.11 C32E8.11 Protein containing a putative zinc finger in N-recognin domain, has a region of weak similarity to a region of ubiquitin-protein ligase (N-recognin or E3 enzyme, S. cerevisiae Ubr1p), which is involved in selection of substrates for the N-end rule pathway C32E8.2 C32E8.2 Protein with high similarity to ribosomal protein L13 (S. cerevisiae Rpl13bp), which is a structural ribosomal protein, member of the ribosomal L13e family, which are part of the large ribosomal subunit ribosomal protein L13; rpl-13 encodes a large ribosomal subunit L13 protein. C32E8.3 C32E8.3 Protein of unknown function, has moderate similarity to uncharacterized human LOC51673 C32E8.4 C32E8.4 Protein with moderate similarity to C. elegans F13E9.8 gene product C32E8.5 C32E8.5 Protein containing a forkhead associated (FHA) domain, which bind phosphopeptides, has high similarity to uncharacterized human FLJ12553 C32E8.6 C32E8.6 Member of the AMP-binding enzyme family, has low similarity to uncharacterized C. elegans C50H11.1 This gene encodes a protein predicted by Eisenberg and coworkers, with 52% accuracy, to be mitochondrial. C32E8.7 ric-19;C32E8.7 Protein with similarity to H. sapiens islet cell autoantigen 1 ), a common target of diabetic autoimmunity in humans and diabetes-prone rodents The ric-19 gene encodes an evolutionarily conserved cytosolic protein involved in neuroendocrine secretion via association with secretory vesicles. C32E8.8 ptr-2;C32E8.8 Member of the patched family, which are transmembrane receptors, has weak similarity to Niemann-Pick disease type C1 (human NPC1), which is a lysosomal protein that plays a role cholesterol transport C32E8.9 C32E8.9 Member of the enoyl-CoA hydratase or isomerase family, has low similarity to a region of short chain enoyl-Coenzyme A hydratase 1 (rat Echs1), which catalyzes the hydration of trans-2-enoyl-CoA forming 3-hydroxyacyl-CoA in fatty acid beta-oxidation C32F10.1 C32F10.1 Member of the oxysterol-binding protein (OSBP) family, which are involved in sterol biosynthesis, contains a pleckstrin homology (PH) domain, which mediate protein-protein and protein-lipid interactions, has region of low similarity to S. cerevisiae Osh7p oxysterol-binding protein C32F10.2 lin-35;C32F10.2 Similar to the Rb tumor suppressor; negative regulator of the cell cycle, and part of the class B pathway that antagonizes vulval induction lin-35 encodes the C. elegans retinoblastoma protein (Rb) ortholog; lin-35 was first identified in screens for synthetic multivulva (synMuv) genes and as a class B synMuv gene, functions redundantly with class A genes to antagonize Ras signaling and negatively regulate vulval development; in addition, LIN-35 activity is required redundantly with PHA-1 and UBC-18 for early steps in pharyngeal morphogenesis, with FZR-1 for normal postembryonic development, and with XNP-1 for somatic gonad development; on its own, LIN-35 is also required for wild-type fertility; LIN-35 is expressed broadly in embryos and L1 larvae, and is then detected in vulval precursor cells and their descendants as well as a subset of head and tail cells in later larvae and adults. C32F10.4 C32F10.4 Protein of unknown function C32F10.5 C32F10.5 Member of the DNA replication related (tentative) protein family single-strand recognition protein C32F10.6 nhr-2;crf-2;C32F10.6 Putative nuclear hormone receptor required for embryogenesis nuclear homone receptor; nhr-2 encodes a member of the nuclear hormone receptor family that is required for embryonic viability and morphogenesis; expressed during embryogenesis. C32F10.7 C32F10.7 Protein of unknown function C32F10.8 C32F10.8 Protein with high similarity to glutamic-pyruvate transaminase (alanine aminotransferase 1, human GPT), which catalyzes the conversion of alanine to pyruvate and alpha-ketoglutarate to glutamate in gluconeogenesis and amino acid metabolism alanine aminotransferase C32H11.1 C32H11.1 Protein containing a DUF141 domain of unknown function, has high similarity to uncharacterized C. elegans K08D8.4 C32H11.10 C32H11.10 Protein containing a DUF141 domain of unknown function, has very strong similarity to uncharacterized C. elegans C32H11.9 C32H11.11 C32H11.11 Protein containing a DUF148 domain of unknown function, has strong similarity to uncharacterized C. elegans C32H11.6 C32H11.12 C32H11.12 Protein containing a DUF141 domain of unknown function, has high similarity to uncharacterized C. elegans C32H11.9 C32H11.13 C32H11.13 Protein containing a DUF141 domain of unknown function, has high similarity to uncharacterized C. elegans F55G11.4 C32H11.2 C32H11.2 Protein containing a DUF216 domain of unknown function, has low similarity to uncharacterized C. elegans F58E2.9 C32H11.3 C32H11.3 Protein containing a DUF141 domain of unknown function, has high similarity to uncharacterized C. elegans C32H11.4 C32H11.4 C32H11.4 Protein containing a DUF141 domain of unknown function, has high similarity to uncharacterized C. elegans C32H11.3 C32H11.5 C32H11.5 Protein containing a DUF148 domain of unknown function, has high similarity to uncharacterized C. elegans C32H11.6 C32H11.6 C32H11.6 Protein containing a DUF148 domain of unknown function, has strong similarity to uncharacterized C. elegans C32H11.11 C32H11.7 C32H11.7 Protein with strong similarity to C. elegans Y38F2AL.6 gene product C32H11.8 C32H11.8 Protein containing a DUF148 domain of unknown function, has very strong similarity to uncharacterized C. elegans C32H11.11 C32H11.9 C32H11.9 Protein containing a DUF141 domain of unknown function, has very strong similarity to uncharacterized C. elegans C32H11.10 C33A11.1 C33A11.1 Protein with four ankyrin repeats, which may mediate protein interactions, has a region of low similarity to human NFKBIA, which is involved in transcription regulation and is associated with Hodgkin lymphoma upon gene mutation Ank repeat C33A11.2 C33A11.2 Protein of unknown function C33A11.4 C33A11.4 Protein containing a sterile alpha motif (SAM) or pointed domain, which are a subgroup of the SAM domains found in nuclear and signalling proteins, and an ETS domain, has a region of high similarity to a region of ETS homologous factor (human EHF) Ets-domain C33A12.1 C33A12.1 Protein of unknown function, has high similarity to NADH-ubiquinone oxidoreductase subunit CI-B13 (human NDUFA5), which is a subunit of the NADH-ubiquinone oxidoreductase (complex I) multiprotein complex that transports during oxidative phosphorylation NADH-ubiquinone oxidoreductase 13 KD-B subunit C33A12.10 C33A12.10 Protein containing a DUF215 domain of unknown function, has high similarity to uncharacterized C. elegans C33A12.11 7TM receptor C33A12.11 C33A12.11 Protein containing a DUF215 domain of unknown function, has high similarity to uncharacterized C. elegans C33A12.10 7TM receptor C33A12.12 C33A12.12 Protein with weak similarity to C. elegans ZYG-11, which is required for zygote formation Leucine Rich Repeat (2 copies) (2 domains) C33A12.13 C33A12.13 Protein containing a DUF215 domain of unknown function, has high similarity to uncharacterized C. elegans C33A12.14 C33A12.14 C33A12.14 Protein containing a DUF215 domain of unknown function, has high similarity to uncharacterized C. elegans C33A12.13 C33A12.15 C33A12.15 Member of the transthyretin-like family Transthyretin-like family C33A12.16 C33A12.16 Protein of unknown function, has low similarity to uncharacterized C. elegans Y77E11A.8 C33A12.2 C33A12.2 Protein of unknown function C33A12.3 C33A12.3 Protein of unknown function C33A12.4 C33A12.4 Protein of unknown function C33A12.5 C33A12.5 Member of the transposase family, which are required for excising and inserting mobile genetic elements, has very strong similarity to uncharacterized C. elegans F44F4.8 transposase C33A12.6 C33A12.6 Protein containing a UDP-glucoronosyl and UDP-glucosyl transferase domain, which transfer glycosyl groups to small hydrophobic molecules, has low similarity to olfactory UDP-glucuronosyltransferase (human UGT2A1), which catalyzes glucuronidation UDP-glucuronysltransferase C33A12.7 C33A12.7 Member of the metallo-beta-lactamase family, has high similarity to uncharacterized human YF13H12 C33A12.8 C33A12.8 Protein containing a DUF215 domain of unknown function, has high similarity to uncharacterized C. elegans C33A12.10 7TM receptor C33B4.1 clc-2;clh-2;B0491.8;C33B4.1 Chloride channel protein C33B4.2 C33B4.2 Protein of unknown function, has high similarity to uncharacterized C. elegans T23F6.2 C33B4.3 C33B4.3 Protein containing six ankyrin (Ank) repeats and a SAM (sterile alpha motif) domain, which may mediate protein-protein interactions, and a PDZ, DHR, or GLGF domain, has low similarity to a region of proline-rich synapse-associated protein 2 (rat Shank3) ankyrin and proline rich domains C33C12.1 C33C12.1 Protein of unknown function C33C12.2 C33C12.2 Protein of unknown function C33C12.3 C33C12.3 Member of the glycosyl hydrolase family 30, which are glucosyl-ceramidases, has moderate similarity to acid beta glucosidase (mouse Gba), which hydrolyzes glucosylceramide and plays a role in the function of the epithelial permeability barrier glucosylceramidase C33C12.4 C33C12.4 Protein of unknown function, has high similarity to uncharacterized C. elegans Y54G2A.15, which may be anchored to the membrane of a secretory vesicle or the Golgi apparatus C33C12.5 C33C12.5 Protein containing an F-box domain, which serve as a link between a target protein and a ubiquitin-conjugating enzyme This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins; its encoded protein also contains a Pfam-B45 motif of presently unknown function. C33C12.6 C33C12.6 Member of the C. elegans Srb family of receptor-like integral membrane proteins, has high similarity to uncharacterized C. elegans SRB-3 C33C12.7 C33C12.7 Protein of unknown function, predicted to contain a glycosylphosphatidylinositol (GPI) lipid anchor C33C12.8 C33C12.8 Member of the glycosyl hydrolase family 30, which are glucosyl-ceramidases, has moderate similarity to acid beta glucosidase (mouse Gba), which hydrolyzes glucosylceramide and plays a role in the function of the epithelial permeability barrier glucosylceramidase C33C12.9 C33C12.9 Protein of unknown function, has high similarity to uncharacterized human N6AMT1 C33D12.1 ceh-31;C33D12.1 Protein containing a homeobox domain (homeodomain), which are found in transcription factors homeobox protein; ceh-31 encodes a protein containing a homeobox domain. C33D12.2 C33D12.2 Protein containing a DUF21 domain of unknown function, has low similarity to a region of S. cerevisiae Ami3p, which is required for normal mitochondrial structure C33D12.2 encodes a homolog of human ACDP1-ACDP4 and a paralog of C01H6.6, C52D10.12, M02F4.3, R04E5.2, and R13G10.4; both C33D12.2 and ACDP1-ACDP4 belong to a family of proteins (defined by NCBI as KOG2118) that are predicted to be membrane-spanning and that share a motif (the 'ACD domain') with proteins from bacteria, yeast, plants, and metazoa; murine Acdp1 is a plasma membrane protein bacterial proteins containing the ACD domain include CorC from Salmonella typhimurium, which is involved in magnesium and cobalt efflux; C33D12.2 has no obvious function in RNAi assays. C33D12.3 twk-3;C33D12.3;M02F4 Member of the 4 TM potassium channel protein family C33D12.6 C33D12.6 Member of the Ras superfamily of GTP-binding proteins, contains two EF hand domains, which are found in signaling, buffering or transport proteins, has a region of moderate similarity to RAB GTPase 1B (human RAB1B), which is involved in protein transport calcium-binding protein C33D12.7 ceh-30;C33D12.7 Protein containing a homeobox domain (homeodomain), which are found in transcription factors, has a region of moderate similarity to a region of bar H like homeobox 2 (mouse Barx2), which is a transcription factor that acts as an activator or repressor homeobox protien; ceh-30 encodes a homeodomain protein most similar to Drosophila and mammalian BarH1 (OMIM:605211) which function in neuronal cell fate determination; the precise biological role of CEH-30 in C. elegans development and/or behavior is not yet known. C33D3.1 elt-2;C33D3.1 Zinc-finger DNA binding factor involved in development of the gut zinc finger protein (GATA type); elt-2 encodes a GATA-type transcription factor most similar to the vertebrate GATA4-6 transcription factors required for cardiac and endoderm development (OMIM:601656, 600576); in C. elegans, ELT-2 is required redundantly with ELT-7 for initiating and maintaining terminal differentiation of the intestine; ELT-2 is expressed solely in the intestine, beginning embryonically at the 2E-cell stage and continuing in all intestinal cells throughout the life of the animal; in the regulatory hierarchy controlling endoderm development, ELT-2 lies downstream of the maternal regulators SKN-1 and POP-1 and the embryonic GATA factors MED-1/-2, and END-1/-3; in turn, ELT-2, along with ELT-7, likely regulates transcription of a number of intestine-specific terminal differentiation genes such as ges-1, ifb-2, pha-4, and the stress-induced mtl-2; ELT-2 also positively autoregulates, presumably to ensure maintenance of intestinal differentiation. C33D3.3 C33D3.3 Protein of unknown function C33D3.4 C33D3.4 Protein of unknown function, has weak similarity to C. elegans Y39A1A.17 C33D9.1 exc-5;fgd-1;C33D9.1 Putative RhoGEF domain protein; putative ortholog of H. sapiens FGD1 gene product, the mutation of which leads to faciogenital dysplasia (Aarskog-Scott syndrome) PH (pleckstrin homology) domain; The exc-5 gene encodes a homolog of human FGD1, which when mutated leads to Aarskog-Scott syndrome (OMIM:305400). C33D9.2 C33D9.2 Member of the C-type lectin family C-lectin binding domain C33D9.3 C33D9.3 Protein of unknown function C33D9.4 C33D9.4 Protein containing a DUF215 domain of unknown function, has high similarity to uncharacterized C. elegans R07B5.6 C33D9.5 C33D9.5 Putative coiled-coil protein, has similarity to human CENPE protein, centromere protein E Yeast RAD50 like protein C33D9.6 C33D9.6 Putative ortholog of C. elegans C33D9.9 gene product C33D9.8 C33D9.8 Putative coiled-coil protein, has weak similarity to myosin heavy chains C33D9.9 C33D9.9 Putative ortholog of C. elegans C33D9.6 gene product C33E10.1 C33E10.1 Protein containing an F-box domain, which serve as a link between a target protein and a ubiquitin-conjugating enzyme, has high similarity to uncharacterized C. elegans F40F4.1 This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins; its encoded protein also contains a Pfam-B45 motif of presently unknown function. C33E10.10 C33E10.10 Putative ortholog of C. elegans T25G12.2 gene product C33E10.2 C33E10.2 Protein containing a DUF38 domain of unknown function and an F-box domain, which serve as a link between a target protein and a ubiquitin-conjugating enzyme, has moderate similarity to C. elegans FOG-2 This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins; this gene's encoded protein also contains an FTH/DUF38 motif, which may also mediate protein-protein interaction. C33E10.5 C33E10.5 Protein of unknown function C33E10.6 C33E10.6 Putative ortholog of C. elegans ZC53.4 gene product C33E10.8 C33E10.8 Protein of unknown function, has weak similarity to C. elegans C52E2.I This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins. C33F10.1 C33F10.1 Protein of unknown function, has strong similarity to uncharacterized C. elegans C33F10.11 C33F10.10 C33F10.10 Protein with moderate similarity to C. elegans F11G11.9 gene product C33F10.11 C33F10.11 Protein of unknown function, has strong similarity to uncharacterized C. elegans C33F10.1 C33F10.12 C33F10.12 Member of the mitochondrial carrier protein family of membrane transporters, has moderate similarity to S. cerevisiae Mir1p, which is a phosphate transporter mitochondrial phosphate carrier protei C33F10.13 C33F10.13 Protein with strong similarity to C. elegans T27E9.8 gene product C33F10.2 C33F10.2 Protein containing two protein kinase domains and a TBC domain, has low similarity to uncharacterized human MGC16169 Cell division control protein C33F10.4 C33F10.4 Putative ortholog of C. elegans C33F10.3 gene product C33F10.5 C33F10.5 Protein with similarity to neural cell adhesion molecules involved in axon guidance; putative member of Ig superfamily fibronectin, IG-like domains of NCAM C33F10.7 C33F10.7 Protein of unknown function, has moderate similarity to uncharacterized C. elegans ZK945.1 esterase and beta-lactamase C33F10.8 C33F10.8 Member of the protein-tyrosine phosphatase family, which are involved in control of cell growth, proliferation, differentiation, has a region of low similarity to a region of human PTPN7, which is a non-receptor protein tyrosine phosphatase protein tyrosine phosphatase; This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins; its encoded protein also contains a Pfam-B45 motif of presently unknown function. C33F10.9 msp-40;C33F10.9 Member of the major sperm protein family major sperm protein; msp-40 encodes a protein that belongs to a family of proteins called the Major Sperm Proteins (MSPs) that is conserved in nematodes; this family consists of closely related, small, basic proteins that make up 15% of sperm protein; this multigene family consists of over fifty genes, including many pseudogenes; MSPs are involved in both extracellular signaling and cytoskeletal functions during reproduction-MSP antagonizes Eph/ephrin signaling, in part, by binding VAB-1 Eph receptor tyrosine kinase on oocytes and sheath cells to promote oocyte maturation and MAPK activation; MSPs assemble into fibrous networks that drive movement of the C. elegans sperm; msp genes are expressed only in late primary spermatocytes. C33G3.1 dyc-1;C33G3.1 Protein containing a phosphotyrosine interaction domain (PTB or PID), which bind various activated tyrosine-phosphorylated receptors dyc-1 encodes a homolog of murine CAPON, a protein associated with neuronal nitric oxide synthase that regulates its interactions with PSD95; DYC-1 is expressed in muscle, and is required for a dystrophin-related function in muscle. C33G3.3 C33G3.3 Protein containing a neurotransmitter-gated ion-channel ligand binding domain, has low similarity to uncharacterized C. elegans Y74E4A.1 C33G3.4 C33G3.4 Protein containing a glycosyl hydrolases family 2 sugar binding domain, has low similarity to mannosidase beta A lysosomal (beta mannosidase, human MANBA), which catalyzes the removal of N-linked mannose residues and is associated with beta-mannosidosis beta-mannosidase; C33G3.4 is orthologous to the human gene BETA-MANNOSIDASE (MANBA; OMIM:248510), which when mutated leads to disease. C33G3.5 C33G3.5 Protein of unknown function, has low similarity to uncharacterized C. elegans F18E9.7 C33G3.6 C33G3.6 Protein of unknown function, has weak similarity to a number of S. cerevisiae proteins, contains a possible coiled-coil domain C33G8.1 C33G8.1 Protein of unknown function, has moderate similarity to uncharacterized C. elegans C44C3.2 7TM chemoreceptor, srw family C33G8.10 C33G8.10 Protein containing a nuclear hormone receptor ligand-binding domain, has high similarity to uncharacterized C. elegans C33G8.9 zinc finger portein C33G8.11 C33G8.11 Protein containing a nuclear hormone receptor C4-type zinc finger domain, which bind DNA, and a nuclear hormone receptor ligand-binding domain, has a region of low similarity to a region of retinoic acid receptor gamma (mouse Rarg) nuclear hormone receptor; nhr-107 encodes a member of the nuclear hormone receptor family. C33G8.12 C33G8.12 Protein containing a nuclear hormone receptor ligand-binding domain, has high similarity to uncharacterized C. elegans C33G8.8 nuclear hormone receptor C33G8.13 C33G8.13 Putative ortholog of C. elegans C13A2.9 gene product C33G8.2 C33G8.2 Protein with moderate similarity to C. elegans Y76G2B.C gene product C33G8.3 C33G8.3 Protein of unknown function, has weak similarity to S. cerevisiae Slz1p, a sporulation-specific protein C33G8.4 C33G8.4 Protein of unknown function, has high similarity to uncharacterized C. elegans F20A1.1 C33G8.5 C33G8.5 Protein of unknown function, has moderate similarity to an uncharacterized G protein-coupled receptor (C. elegans F59A7.3) 7TM chemoreceptor, srab family C33G8.6 nhr-42;C33G8.6 Member of the nuclear hormone receptor/Zinc finger protein family zinc finger protein C33G8.7 C33G8.7 Protein containing a nuclear hormone receptor ligand-binding domain and a nuclear hormone receptor C-4 type zinc finger domain, has weak similarity to a region of hepatocyte nuclear factor 4 alpha (rat Hnf4a), which is a transcription factor zinc finger protein C33G8.8 C33G8.8 Protein containing a nuclear hormone receptor ligand-binding domain, has high similarity to uncharacterized C. elegans C33G8.10 zinc finger protein C33G8.9 C33G8.9 Protein containing a nuclear hormone receptor C4-type zinc finger domain, which bind DNA and may be involved in regulation of transcription, and a nuclear hormone receptor ligand-binding domain, has high similarity to uncharacterized C. elegans C33G8.10 zinc finger protein C33H5.1 C33H5.1 Member of the domain of unknown function DUF13 family, has high similarity to uncharacterized C. elegans K01D12.1 C33H5.10 C33H5.10 Protein of unknown function C33H5.11 C33H5.11 Protein with weak similarity to C. elegans T05E11.5 gene product C33H5.12 rsp-6;srp-1;CeSRp20;C33H5.12 SR protein involved in mRNA splicing RNA binding protein C33H5.13 C33H5.13 Protein of unknown function C33H5.14 C33H5.14 Putative uridine diphosphatase, member of the GDA1/CD39 (nucleoside phosphatase) protein family C33H5.15 C33H5.15 Protein of unknown function C33H5.16 C33H5.16 Protein with high similarity to C. elegans F10G8.1, which is involved in embryogenesis or morphogenesis, member of the protein-tyrosine phosphatase family, which are involved in control of cell growth, proliferation, differentiation and transformation protein-tyrosine phophatase C33H5.17 C33H5.17 Protein containing a CCCH-type zinc finger domain, which bind DNA or RNA, and a G-patch domain, which are found in RNA processing proteins, has weak similarity to uncharacterized human KIAA1847 C33H5.18 C33H5.18 Putative ortholog of C. elegans C33H5.18A gene product CDP-diacylglycerol synthase; C33H5.18 encodes a CDP-diglyceride synthetase ortholog required for locomotion and osmoregulation; given its biochemical function in other organisms, C33H5.18 is expected to catalyse synthesis of cytidine diphosphate-diacylglycerol (CDP-DAG), an activated precursor for anionic and zwitterionic phospholipids, and is likely to regulate phosphatidylinositol lipid signalling; one might expect loss of C33H5.18 function to be lethal, but its deficiency may be supplemented by lipids in food. C33H5.19 C33H5.19 Protein of unknown function C33H5.2 C33H5.2 Protein containing a DUF23 domain of unknown function, has high similarity to uncharacterized C. elegans F49C12.5 C33H5.3 C33H5.3 Protein with moderate similarity to C. elegans klp-18 gene product C33H5.4 klp-10;C33H5.4 Protein containing a kinesin domain, which binds ATP and microtubules, has low similarity to kinesin family member 3a (mouse Kif3a), which is a motor protein that acts in intracellular organelle transport and determination of embryonic body patterning klp-10 encodes a kinesin-like motor protein that displays similarity to diverse types of kinesin motor domains such as those found in C. elegans OSM-3, the vertebrate CHO1/MKLP proteins, and Saccharomyces cerevisiae Kip3; KLP-10 is required for embryogensis, may play a role in meiosis, and has been implicated in chromosome segregation and cell cycle progression. C33H5.6 C33H5.6 Protein containing four WD domains (WD-40 repeats), which may mediate protein-protein interactions, has moderate similarity to uncharacterized C. elegans C33H5.7 C33H5.7 C33H5.7 Protein containing four WD domains (WD-40 repeats), which may mediate protein-protein interactions, has low similarity to uncharacterized C. albicans Orf6.3607p C33H5.8 C33H5.8 Protein containing two TPR (tetratrico peptide repeat) domains, which may mediate protein-protein interactions, has low similarity to uncharacterized C. albicans Orf6.8272p C33H5.9 C33H5.9 Putative ortholog of human brain secretory protein hSec10p (HSEC10, Hs.29494) C34B2.1 C34B2.1 Protein of unknown function C34B2.10 C34B2.10 Protein of unknown function C34B2.11 C34B2.11 Protein of unknown function C34B2.2 C34B2.2 Protein of unknown function, has similarity to S. cerevisiae Ylr254p, has similarity to a region of S. cerevisiae Zip1p (component of the synaptonemal complex) C34B2.3 C34B2.3 Protein with low similarity to C. elegans Y106G6E.6, which is a serine-threonine protein kinase protein kinase C34B2.4 C34B2.4 Protein containing two LIM domains, which may mediate protein-protein interactions, has moderate similarity to a region of z-band alternatively spliced PDZ-motif protein (human LDB3), which is a Z-band component that interacts with alpha-actinin-2 C34B2.5 C34B2.5 Protein of unknown function, has moderate similarity to a region of tetratricopeptide repeat domain 1 (human TTC1), which interacts with the GAP-related domain of neurofibromin (NF1) and may be involved in protein folding C34B2.6 C34B2.6 Protein with high similarity to protease serine 15 (human PRSS15), which is a mitochondrial peptidase that binds single-stranded DNA, member of the ATPase family associated with various cellular activities, contains an ATP-dependent serine protease domain protease; This gene encodes a protein predicted by Eisenberg and coworkers, with 52% accuracy, to be mitochondrial. C34B2.7 C34B2.7 Protein with high similarity to succinate dehydrogenase complex subunit A (human SDHA), which is an electron transporter associated with Leigh syndrome, contains fumarate reductase or succinate dehydrogenase flavoprotein C-terminal and FAD binding domains flavoprotein; This gene encodes a protein predicted by Eisenberg and coworkers, with 52% accuracy, to be mitochondrial. C34B2.8 C34B2.8 Protein of unknown function C34B2.9 C34B2.9 Protein of unknown function C34B4.1 C34B4.1 Protein with weak similarity to H. sapiens MYO7A (myosin VIIA (Usher syndrome 1B (autosomal recessive, severe))) PH (pleckstrin homology) domain C34B4.2 C34B4.2 Protein containing an activin type I or II receptor domain, which are found in the extracellular region of some growth factor receptors Activin types I and II receptor domain C34B7.1 C34B7.1 Putative ortholog of S. cerevisiae Esa1p, a histone acetyltransferase and member of the MYST family The C34B7.1 gene encodes a divergent MYST acetyltransferase that is (apparently) unique to Caenorhabditis; it has no well-characterized orthologs in the complete Drosophila or S. cerevisiae genomes, and no obvious orthologs in the draft human genome sequence either. C34B7.2 C34B7.2 Protein containing a SacI homology domain, has a region of low similarity to suppressor of actin 1 (rat Sacm1l), which is an integral membrane lipid phosphatase that acts on PI 3 phosphate, PI 4 phosphate, and PI 3,5 bisphosphate Yeast hypothetical protein YNOD like C34B7.3 C34B7.3 Member of the cytochrome P450 family, has low similarity to cytochrome P450 2c29 (mouse Cyp2c29), which is a major cannabinoid metabolizing enzyme in liver microsomes and is involved in detoxification of other xenobiotics and drugs cytochrome P450 C34B7.4 C34B7.4 Putative ortholog of C. elegans VC5.4 gene product C34C12.1 C34C12.1 Putative ortholog of C. elegans Y47H9C.9 gene product C34C12.2 C34C12.2 Protein containing two coiled-coil domains, has weak similarity to S. cerevisiae Abp1p and Net1p C34C12.3 C34C12.3 PP2A-type serine/threonine protein phosphatase PROTEIN PHOSPHATASE C34C12.4 C34C12.4 Protein of unknown function C34C12.5 C34C12.5 Protein with high similarity to ras suppressor 1 (human RSU1), which may suppress v-Ras transformation and may be involved in Ras signal transduction, contains seven leucine rich repeats, which mediate protein-protein interactions RSP1 protein C34C12.6 C34C12.6 Protein containing a CRAL-TRIO domain, has weak similarity to uncharacterized C. elegans T03F7.7 C34C12.7 C34C12.7 Protein of unknown function that may be anchored to the membrane of a secretory vesicle or the Golgi apparatus C34C12.8 C34C12.8 Protein with high similarity to stress-inducible chaperone mt-GrpE#1 (rat GrpE#1), which is a mitochondrion-specific nucleotide-exchange factor chaperone that stimulates the ATPase activity of mitochondrial rat Hsp70, member of the GrpE family GRPE protein; This gene encodes a protein predicted by Eisenberg and coworkers, with 52% accuracy, to be mitochondrial. C34C6.1 C34C6.1 Member of the C. elegans Srg family of integral membrane proteins, which may be involved in chemosensation, has high similarity to uncharacterized C. elegans F15A4.4 G-protein coupled receptor, srg family C34C6.2 C34C6.2 Protein of unknown function C34C6.3 C34C6.3 Protein with strong similarity to C. elegans C09F9.2 gene product EGF receptor/notch-like protein C34C6.4 C34C6.4 Member of the GMC oxidoreductase family of FAD-containing proteins, has low similarity to glucose oxidase (A. niger Ggox), which is induced by calcium carbonate choline dehydrogenase C34C6.5 C34C6.5 Putative sphingosine kinase Diacylglycerol kinase catalytic domain (presumed) C34C6.6 pex-5;C34C6.6 Strongly similar to human peroxisome receptors and S. cerevisiae Pex5p, a receptor for the peroxisomal target signal type I, PTS1 peroxisomal-like protein; prx-5 encodes an ortholog of the human receptor for type I peroxisomal targeting signal protein, PXR1 (or PEX5; OMIM:600414), which when mutated leads to neonatal adrenoleukodystrophy or Zellweger syndrome; PXR1 protein is a component of the peroxisomal import machinery known to exist in organisms like yeast, plants and mammals. C34C6.7 C34C6.7 Protein of unknown function C34C6.8 ceh-7;C34C6.8 Homeodomain transcription factor, has similarity over the homeodomain to many human and D. melanogaster homeodomain transcription factors Homeobox domain; ceh-7 encodes a homeodomain transcription factor; expressed in cells around the rectum of the male tail. C34D1.1 C34D1.1 Protein containing one DM (dsx and mab-3) DNA binding domain DM DNA binding domain C34D1.2 C34D1.2 Protein containing one DM (dsx and mab-3) DNA binding domain, has a region of moderate similarity to a region of C. elegans MAB-3, which is required for sex-specific production of yolk proteins and male tail development DM DNA binding domain C34D1.3 odr-3;C34D1.3 G-protein alpha subunit protein required for signal transduction from ODR-10 diacetyl receptor in sensory neurons guanine nucleotide-binding protein C34D1.4 C34D1.4 Protein of unknown function C34D1.5 C34D1.5 Protein containing a bZIP (basic-leucine zipper) transcription factor domain Basic region plus leucine zipper transcription factors C34D10.1 C34D10.1 Protein containing a major sperm protein (MSP) domain, which are involved in sperm motility, has moderate similarity to uncharacterized human DJ473B4 C34D10.2 C34D10.2 Protein containing three CCCH-type zinc finger domains, which bind DNA or RNA Cys(3)His finger protein (D. melanogaster) C34D4.1 C34D4.1 Putative ortholog of C. elegans C42D4.7 gene product C34D4.10 C34D4.10 Protein of unknown function C34D4.11 C34D4.11 Protein of unknown function C34D4.12 C34D4.12 Protein with high similarity to C. elegans CYP-10, which is a cyclophilin-related peptidylprolyl cis-trans-isomerase, member of the cyclophilin type peptidyl-prolyl cis-trans isomerase family cyp-12 encodes a member of the cyclophilin family. C34D4.13 C34D4.13 Protein of unknown function C34D4.14 C34D4.14 Protein containing two ankyrin repeats, which may mediate protein-protein interactions, and a HECT domain, which may confer ubiquitin-protein ligase activity, has a region of low similarity to a region of S. cerevisiae Ufd4p C34D4.15 C34D4.15 Protein containing two collagen triple helix repeats, which are found in some extracellular proteins, and a nematode cuticle collagen N-terminal domain, has low similarity to C. elegans SQT-1, which is a collagen C34D4.2 C34D4.2 PP1-type serine/threonine protein phosphatase C34D4.3 C34D4.3 Protein containing a major sperm protein (MSP) domain, which are involved in sperm motility, has high similarity to uncharacterized C. elegans ZK1307.3 C34D4.4 C34D4.4 Protein of unknown function, has low similarity to uncharacterized C. albicans Orf6.7349p C34D4.5 C34D4.5 Member of the reverse transcriptase protein family, which are RNA-dependent DNA polymerases, has high similarity to uncharacterized C. elegans F56C9.2 C34D4.8 C34D4.8 Member of the 7-transmembrane chemoreceptor family of G protein-coupled receptors (GPCR), has low similarity to C. elegans ODR-10, which is a G protein-coupled receptor involved in odorant response 7TM chemoreceptor, str family C34D4.9 C34D4.9 Member of the astacin (M12A) family of metalloproteases, has a region of moderate similarity to a region of the beta subunit of meprin A (rat Mep1b), which is an integral membrane protein that may play a role in embryogenesis C34E10.1 gop-3;C34E10.1 Protein of unknown function, has low similarity to uncharacterized human CGI-51 gop-3 encodes an ortholog of the mammalian CGI-51 (comparative gene identification-51) proteins that display a high degree of similarity to the Haemophilus influenza D15 protective surface antigen; loss of gop-3 activity via large-scale RNAi screens indicates that GOP-3 is required for embryonic and larval development, as well as for normal postembryonic growth rates. C34E10.10 C34E10.10 Protein with moderate similarity to C. elegans F30A10.9 gene product C34E10.11 C34E10.11 Protein of unknown function C34E10.2 gop-2;C34E10.2 Member of the Ylr243p/Yor262p-like protein family gop-2 encodes a member of the conserved hypothetical ATP binding protein family that affects embryonic viability, growth, and fertility. C34E10.3 gop-1;C34E10.3 Protein of unknown function, has low similarity to uncharacterized human KIAA0350 C34E10.4 C34E10.4 Member of the class I tryptophanyl and tyrosyl (W and Y) tRNA synthetase family, contains a C3HC4 type (RING) zinc finger, which may mediate protein-protein interactions, has a region of moderate similarity to tryptophanyl tRNA synthetase 2 (human WARS2) wrs-2 encodes a tryptophanyl (W) tRNA synthetase predicted to be mitochondrial. C34E10.5 C34E10.5 Protein with low similarity to protein arginine methyltransferase 5 (human PMRT5), which methylates target proteins on arginine residues and may inhibit mitosis C34E10.6 atp-2;C34E10.6 Protein with strong similarity to beta subunit of mitochondrial F1 ATP synthase (human ATP5B), contains two ATP synthase alpha or beta family nucleotide-binding and C-terminal domains and two beta-barrel domains ATP synthase beta chain; atp-2 encodes the ATP synthase beta (active site) subunit of mitochondrial respiratory chain (MRC) complex V; ATP-2 is required for normal mobility, pharyngeal pumping, defecation, growth, and lifespan, and is also required for development past the third larval stage. C34E10.7 cnd-1;C34E10.7 Protein containing one helix-loop-helix DNA-binding domain, which mediate protein dimerization, has moderate similarity to a region of neurogenic differentiation protein 1 (rat Neurod1), which is a transcription factor regulating neuronal differentiation cnd-1 is orthologous to the human gene NEUROGENIC DIFFERENTIATION 1 (NEUROD1; OMIM:601724), which when mutated leads to disease. C34E10.8 C34E10.8 Protein of unknown function C34E10.9 C34E10.9 Protein of unknown function C34E11.1 C34E11.1 Protein containing an epsin N-terminal homology (ENTH) domain, has low similarity to epsin 1 (human EPSIN), which is a component of a multi-protein complex that plays a role in clathrin-mediated endocytosis yeast hypothetical L8167.6 like C34E11.2 C34E11.2 Protein of unknown function C34E11.3 C34E11.3 Putative coiled-coil protein, has similarity to S. cerevisiae Msp1p, a myosin-like protein C34E7.1 C34E7.1 Protein of unknown function, has weak similarity to human KIAA0181, a CAG repeat-containing protein (Hs.159613) The protein product of this gene is predicted to contain a glutamine/asparagine (Q/N)-rich ('prion') domain, by the algorithm of Michelitsch and Weissman (as of the WS77 release of WormBase, i.e., in wormpep77). C34E7.2 C34E7.2 Protein of unknown function C34E7.3 C34E7.3 Protein of unknown function C34E7.4 C34E7.4 Protein with moderate similarity to C. elegans C05E7.2 gene product C34F11.1 C34F11.1 Protein with moderate similarity to C. elegans T24D1.3 gene product C34F11.2 C34F11.2 Protein of unknown function, has high similarity to uncharacterized C. elegans Y73F8A.14 C34F11.3 C34F11.3 Protein with high similarity to adenosine monophosphate deaminase 2 (isoform L) (human AMPD2), which catalyzes the deamination of adenosine monophosphate in purine nucleotide metabolism, member of the adenosine and AMP deaminase family AMP deaminase C34F11.4 msp-50;C34F11.4 Member of the major sperm protein family major sperm protein; msp-50 encodes a protein that belongs to a family of proteins called the Major Sperm Proteins (MSPs) that is conserved in nematodes; this family consists of closely related, small, basic proteins that make up 15% of sperm protein; this multigene family consists of over fifty genes, including many pseudogenes; MSPs are involved in both extracellular signaling and cytoskeletal functions during reproduction-MSP antagonizes Eph/ephrin signaling, in part, by binding VAB-1 Eph receptor tyrosine kinase on oocytes and sheath cells to promote oocyte maturation and MAPK activation; MSPs assemble into fibrous networks that drive movement of the C. elegans sperm; msp genes are expressed only in late primary spermatocytes. C34F11.5 C34F11.5 Protein containing a Src homology 2 (SH2) domain and a protein kinase domain, has weak similarity to thousand and one amino acid protein kinase (rat Tao1), which is involved in regulating the p38-containing stress responsive MAP kinase pathway tyrosine-protein kinase C34F11.6 msp-49;C34F11.6 Member of the major sperm-specific protein (MSP) family major sperm protein; msp-49 encodes a protein that belongs to a family of proteins called the Major Sperm Proteins (MSPs) that is conserved in nematodes; this family consists of closely related, small, basic proteins that make up 15% of sperm protein; this multigene family consists of over fifty genes, including many pseudogenes; MSPs are involved in both extracellular signaling and cytoskeletal functions during reproduction-MSP antagonizes Eph/ephrin signaling, in part, by binding VAB-1 Eph receptor tyrosine kinase on oocytes and sheath cells to promote oocyte maturation and MAPK activation; MSPs assemble into fibrous networks that drive movement of the C. elegans sperm; msp genes are expressed only in late primary spermatocytes. C34F11.8 C34F11.8 Protein of unknown function C34F11.9 C34F11.9 Protein containing 3 PDZ, DHR, or GLGF domains, 3 dishevelled specific domains, 2 DIX or DAX (dishevelled and axin) domains, and 3 domains of unknown function, has moderate similarity to dishevelled 1 (human DVL1), which is in the Wnt and Notch pathways dishevelled-like protein; dsh-1 encodes a homolog of Drosophila DISHEVELED and a paralog of MIG-5 (and DSH-2); DSH-1 appears to be required for Wnt-induced endoderm specification in the EMS blastomere, and may influence HSN migration as well. C34F6.1 C34F6.1 Protein containing eight kunitz or bovine pancreatic trypsin inhibitor domains, has a region of low similarity to tissue factor pathway inhibitor (human TFPI), which inhibits factor Xa and factor VIIa-tissue factor complex to prevent fibrin clot formation Kunitz/Bovine pancreatic trypsin inhibitor domain (8 domains) C34F6.10 C34F6.10 Protein containing four fibronectin type III domains, which are involved in cell surface binding Fibronectin type III domain (4 domains) C34F6.2 C34F6.2 Protein containing two collagen triple helix repeats, which are found in some extracellular proteins, and a nematode cuticle collagen N-terminal domain, has a region of high similarity to a region of human COL6A1, which is associated with Bethlem myopathy collagen C34F6.3 C34F6.3 Protein containing two collagen triple helix repeats, which are found in some extracellular proteins, has a region of high similarity to a region of collagen type VI, alpha 1 (human COL6A1), which is associated with Bethlem myopathy upon gene mutation collagen C34F6.4 C34F6.4 Protein of unknown function, has a region of high similarity to heparan sulfate 2-O-sulfotransferase 1 (mouse Hs2st1), which is a sulfotransferase enzyme that plays a role in heparan sulfate proteoglycan biosynthesis and kidney development C34F6.5 C34F6.5 Protein of unknown function C34F6.6 C34F6.6 Protein of unknown function C34F6.7 C34F6.7 Protein of unknown function C34F6.8 C34F6.8 Protein with high similarity to mouse Idh2, which is a mitochondrial isocitrate dehydrogenase, member of the isocitrate and isopropylmalate dehydrogenase family, which are oxidoreductases involved in metabolism Isocitrate and isopropylmalate dehydrogenases C34F6.9 C34F6.9 Protein with weak similarity to C. elegans T22F3.2 gene product Ubiquitin carboxyl-terminal hydrolases family 2 C34G6.1 C34G6.1 Protein with moderate similarity to D. melanogaster c11.1 (Protein of unknown function) C34G6.2 C34G6.2 Protein containing two tyrosinase central domains, which are copper-binding domains, has a region of low similarity to a region of tyrosinase (human TYR), which is required for melanin synthesis and is associated with type I oculocutaneous albinism C34G6.3 C34G6.3 Protein of unknown function, has strong similarity to uncharacterized C. elegans Y67A6A.1 C34G6.4 pgp-2;C34G6.4 P-glycoprotein, multidrug resistance protein of the ATP-binding cassette (ABC) superfamily, has strong similarity to human, Drosophila, and S. cerevisiae multidrug resistance proteins abc transporter; pgp-2 encodes a member of the ABC transporter family with highest similarity to the vertebrate MDR (multidrug resistance) family, and is orthologous to human MDR1 (ABCB1; OMIM:171050, mutated in Crohn disease); PGP-2 is expressed at lower levels during the embryonic stages with higher expression later in development. C34G6.5 C34G6.5 Protein containing a protein kinase domain, has low similarity to S. cerevisiae Cdc7p, which is a protein kinase that interacts with S. cerevisiae Dbf4p to affect DNA synthesis initiation, commitment to sporulation, DNA repair, and meiotic recombination ser/thr-protein kinase C34G6.6 C34G6.6 Member of an uncharacterized protein family C34G6.7 C34G6.7 Protein containing a Src homology 3 (SH3) domain, a ubiquitin interaction motif, and a VHS domain of unknown function, has low similarity to signal transducing adaptor molecule 1 (human STAM), which is involved in signal transduction The protein product of this gene is predicted to contain a glutamine/asparagine (Q/N)-rich ('prion') domain, by the algorithm of Michelitsch and Weissman (as of the WS77 release of WormBase, i.e., in wormpep77). C34H3.1 C34H3.1;mig-17 Protein with moderate similarity to C. elegans F27D9.7 C34H3.2 C34H3.2 Protein with strong similarity to D. melanogaster odd (odd skipped) C2H2-type zinc finger protein; odd-2 encodes a protein with homology to the Drosophila ODD-SKIPPED family members and affects larval viability; expressed in the intestine. C34H4.1 C34H4.1 Protein predicted to contain a glycosylphosphatidylinositol (GPI) lipid anchor C34H4.2 C34H4.2 Protein of unknown function, has moderate similarity to uncharacterized C. elegans K11H12.4 C34H4.3 C34H4.3 Protein of unknown function, has low similarity to uncharacterized C. elegans K11H12.4 C34H4.4 C34H4.4 Protein containing a collagen triple helix repeat, which are found in some extracellular proteins, and a nematode cuticle collagen N-terminal domain, has a region of moderate similarity to a region of C. elegans BLI-1 cuticular collagen C35A11.1 C35A11.1 Member of the rhodopsin family of G protein-coupled receptors (GPCR), has moderate similarity to uncharacterized C. elegans D1069.4 C35A11.2 C35A11.2 Protein of unknown function C35A11.3 C35A11.3 Protein of unknown function, has high similarity to uncharacterized C. elegans F49C5.7 C35A11.4 C35A11.4 Member of the hexose transporter family of the major facilitator superfamily [MFS] sugar transporter C35A5.1 C35A5.1 Member of the major intrinsic protein (MIP) family, which are transmembrane channels, has moderate similarity to C. elegans AQP-CE2, which is a mercury-sensitive water channel protein tonoplast channel protein C35A5.2 C35A5.2 Protein containing a UDP-glucoronosyl and UDP-glucosyl transferase domain, which transfer glycosyl groups to small hydrophobic molecules, has low similarity to UDP glycosyltransferase 1 family polypeptide A1 (human UGT1A) UDP-glucuronosyltransferase C35A5.3 C35A5.3 Protein with similarity to human and D. melanogaster sodium-dependent inorganic phosphate cotransporters, member of the major facilitator superfamily sodium/phosphate transport protein C35A5.4 C35A5.4 Protein containing a major sperm protein (MSP) domain, which are involved in sperm motility C35A5.5 C35A5.5 Protein containing a DUF23 domain of unknown function C35A5.6 C35A5.6 Protein of unknown function C35A5.7 C35A5.7 Protein of unknown function, has low similarity to uncharacterized C. elegans F57B7.1 transmembranous domains C35A5.8 C35A5.8 Protein with moderate similarity to ran-binding protein 16 (human RANBP16), which binds to Ran-GTP and may regulate Ran function and act as a nuclear transport protein C35A5.9 C35A5.9 Member of the histone deacetylase family, which catalyze removal of acetyl groups from histones C35B1.1 ubc-1;C35B1.1 Type II ubiquitin-conjugating enzyme ubiquitin conjugating-protein; ubc-1 encodes an E2 ubiquitin-conjugating enzyme that contains a novel 40 amino acid C-terminal tail, and is homologous to Saccharomyces cerevisiae RAD6/UBC2 which is involved in DNA repair; although loss of UBC-1 activity via RNA-mediated interference (RNAi) does not result in any abnormalities, UBC-1 is able to complement the DNA repair defects of a Saccharomyces cerevisiae rad6 null mutant, suggesting that UBC-1 can function in the DNA repair pathway; ubc-1 mRNA is detectable in embryos. C35B1.2 C35B1.2 Protein with moderate similarity to C. elegans Y39B6A.B gene product C35B1.3 C35B1.3 Protein of unknown function C35B1.4 C35B1.4 Protein of unknown function C35B1.5 C35B1.5 Protein with high similarity to C. elegans R05H5.3, which is a putative nuclear thioredoxin involved in embryogenesis and morphogenesis C35B1.6 C35B1.6 Protein of unknown function C35B1.7 C35B1.7 Protein of unknown function C35B8.1 C35B8.1 Protein containing two collagen triple helix repeats, which are found in some extracellular proteins, and a nematode cuticle collagen N-terminal domain, has moderate similarity to a region of C. elegans BLI-1 Cuticle collagen C35B8.2 C35B8.2 Protein with strong similarity to human VAV1, VAV2, and VAV-3 (Hs.37331) proto-oncogene products vav proto-oncogene; vav-1 encodes an ortholog of the Vav proto-oncogene, a complex protein with several domains, from N- to C-terminus: a calponin-like actin-binding domain; a RhoGEF/DH domain; a pleckstrin-like domain; a SH2 motif domain; and an SH3 domain. C35B8.3 C35B8.3 Protein of unknown function C35C5.1 sdc-2;C35C5.1 Hermaphrodite specific protein involved in sex determination; directs the dosage compensation complex to X chromosome in hermaphrodites; has weak similarity to S. cerevisiae USO1 gene product The sdc-2 gene encodes a protein that represses transcription of X chromosomes to achieve dosage compensation, and that also represses the male sex-determination gene her-1 to elicit hermaphrodite differentiation. C35C5.2 C35C5.2 Putative transferrin receptor C35C5.3 C35C5.3 Protein of unknown function, has moderate similarity to uncharacterized C. elegans F28H7.4 C35C5.4 mig-2;C35C5.4 GTP-binding protein of the rho family (ras superfamily), required for normal migration of axons, neurons, and mesodermal cells during embryogenesis RAS-related protein; mig-2 encodes a member of the Rho family of GTP-binding proteins that affects the migration of Q neuroblasts, HSN cells, and CAN cells as well as axon outgrowth and guidance; it is expressed in early embryos and expressed in adults in the vulva, distal tip cells of the gonad, and the sex myoblasts and their descendants. C35C5.5 acr-13;C35C5.5 Protein containing neurotransmitter-gated ion-channel ligand binding and transmembrane domains, has low similarity to C. elegans UNC-38, which is a nicotinic acetylcholine receptor alpha subunit acetylcholine receptor C35C5.6 C35C5.6 Protein of unknown function C35C5.8 C35C5.8 Protein of unknown function, has low similarity to uncharacterized C. elegans F16C3.2 C35C5.9 C35C5.9 Protein of unknown function C35D10.1 C35D10.1 Protein that has strong similariy to a subunit of the ARP2/3 actin-organizing complex in its N-terminus C35D10.10 C35D10.10 Protein of unknown function, has moderate similarity to uncharacterized human LOC51075 C35D10.11 C35D10.11 Member of an uncharacterized protein family C35D10.12 C35D10.12 Protein of unknown function, has low similarity to uncharacterized human KIAA1456 C35D10.13 C35D10.13 Protein of unknown function C35D10.14 C35D10.14 Member of the C-type lectin family, has similarity to human C-type mannose receptor MRC1, has similarity to D. melanogaster TOLLOID and TOLKIN proteins C-type lectin domain C35D10.15 C35D10.15 Putative ortholog of C. elegans C35D10.14 gene product C35D10.16 C35D10.16 Protein of unknown function C35D10.2 C35D10.2 Putative paralog of C. elegans F44D12.4 gene product C35D10.3 C35D10.3 Protein of unknown function C35D10.4 C35D10.4 Member of the ABC1 family, has a region of moderate similarity to S. cerevisiae Abc1p, which is required for coenzyme Q biosynthesis and the activity of cytochrome bc1 complex coq-8 encodes a protein orthologous to COQ8 from S. cerevisiae and homologous to ABC1 from S. cerevisiae and AarF from E. coli; COQ-8 is required for ubiquinone biosynthesis and for normally short lifespan; the biochemical function of COQ-8 is unknown, but it may be a chaperonin; coq-8(RNAi) animals have reduced levels of coenzyme Q8, coenzyme Q9, and superoxide, and have abnormally long lifespans. C35D10.5 C35D10.5 Protein of unknown function, has low similarity to uncharacterized mouse Bfzb C35D10.6 C35D10.6 Member of the aldo-keto reductase family, which include some related monomeric NADPH-dependent oxidoreductases, has low similarity to aldose reductase (human AKR1B1), which catalyzes glucose to sorbitol reduction and contributes to diabetes complications Aldose reductase C35D10.7 C35D10.7;C35D10.7 Protein of unknown function C35D10.8 C35D10.8 Protein with moderate similarity to C. elegans Y37E11AL.2 gene product C35D10.9 ced-4;C35D10.9 Caspase-binding adapter protein required for programmed cell death The ced-4 gene encodes a protein required for apoptosis. C35D6.1 C35D6.1 Member of the 7-transmembrane chemoreceptor family of G protein-coupled receptors (GPCR), has very strong similarity to uncharacterized C. elegans C35D6.2 C35D6.2 C35D6.2 Member of the 7-transmembrane chemoreceptor family of G-protein coupled receptors (GPCR), has very strong similarity to uncharacterized C. elegans C35D6.1 C35D6.3 C35D6.3 Protein with strong similarity to C. elegans Y71A12B.3 gene product C35D6.4 C35D6.4 Protein containing two CCCH-type zinc finger domains, which bind DNA or RNA, has moderate similarity to C. elegans POS-1, which is a cytoplasmic zinc-finger protein involved in regulation of early morphogenesis Zinc finger C-x8-C-x5-C-x3-H type (and similar). (2 domains) C35D6.5 C35D6.5 Putative ortholog of C. elegans K06H6.2 gene product C35E7.1 C35E7.1 Protein with moderate similarity to C. elegans F44F1.6 gene product C35E7.10 C35E7.10 Protein containing protein kinase and Src homology 2 (SH2) domains, has moderate similarity to a region of fer (fps/fes related) tyrosine kinase (human FER), which may mediate cell-cell signaling, cytoskeletal reorganization, cell growth and cell adhesion protein kinase C35E7.11 C35E7.11 Protein of unknown function C35E7.2 C35E7.2 Protein with moderate similarity to C. elegans C35E7.3 gene product C35E7.3 C35E7.3 Protein with strong similarity to C. elegans F42G2.6 gene product C35E7.4 C35E7.4 Protein with strong similarity to C. elegans C35E7.5 gene product C35E7.5 C35E7.5 Protein with strong similarity to C. elegans C35E7.4 gene product C35E7.6 C35E7.6 Protein of unknown function, has weak similarity to C. elegans T04D3.1 C35E7.7 C35E7.7 Protein of unknown function, has weak similarity to C. elegans F56H1.2 C35E7.8 C35E7.8 Putative ortholog of C. elegans F36H12.2 gene product C35E7.9 C35E7.9 Protein containing a major sperm protein (MSP) domain, which are involved in sperm motility, has high similarity to uncharacterized C. elegans F36H12.3 C36A4.1 C36A4.1 Member of the cytochrome P450 family, has low similarity to cytochrome P450 subfamily 3A polypeptide 4 (human CYP3A4), which is a major drug metabolizing enzyme that oxidizes the calcium channel blocking drug nifedipine as well as other dihydropyridines cytochrome P450 C36A4.10 C36A4.10 Protein of unknown function C36A4.2 C36A4.2 Member of the cytochrome P450 family, has low similarity to cytochrome P450 subfamily 3A polypeptide 9 (rat Rn.10489), which demethylates erythromycin and benzphetamine and is expressed in a sexually dimorphic female specific pattern upon puberty onset cytochrome P450 C36A4.4 C36A4.4 Member of the UTP-glucose-1-phosphate uridylyltransferase family, which catalyze formation of UDP-glucose, has moderate similarity to UDP-N-acetylglucosamine pyrophosphorylase 1 (sperm associated antigen 2, human UAP1) C36A4.5 C36A4.5 Protein of unknown function, has strong similarity to uncharacterized C. elegans F25D7.4 claustrin like C36A4.6 C36A4.6 Member of the cytochrome P450 family, has low similarity to steroid inducible cytochrome P450 3a11 (mouse Cyp3a11), which is a microsomal enzyme that catalyzes oxidation of tetrahydrocannabinol compounds and may be involved in xenobiotic responses cytochrome P450 C36A4.7 C36A4.7 Member of the transposase family, which are required for excising and inserting mobile genetic elements, has very strong similarity to uncharacterized C. elegans C10H11.2 transposase C36A4.8 C36A4.8 Protein containing a C3HC4 type (RING) zinc finger, which may mediate protein-protein interactions, and a BRCA1 (breast cancer type 1) C terminus (BRCT) domain, which are found in some cell cycle checkpoint proteins Zinc finger, C3HC4 type (RING finger); The brc-1 gene encodes a homolog of human BRCA1, which when mutated leads to early onset breast and ovarian cancer (OMIM:113705). C36A4.9 C36A4.9 Protein with high similarity to acetyl-Coenzyme A synthetase 2 (acetyl-CoA synthetase, human ACAS2), which catalyzes the ATP-dependent condensation of acetate and coenzyme A to form acetyl-CoA, member of the AMP-binding enzyme family acetyl-coenzyme A synthetase C36B1.10 C36B1.10 Protein containing a protein kinase domain, has low similarity to S. pombe Skp1p, which is a serine/threonine kinase involved in cytokinesis serine/threonine kinase C36B1.11 C36B1.11 Protein of unknown function, has moderate similarity to uncharacterized C. elegans Y48G10A.2 C36B1.12 C36B1.12 Protein of unknown function, has a region of low similarity to histocompatibility 13 (mouse H13), which is a minor antigen and source of the Db MHC class I molecule presented nonapeptide that induces a cellular immune response resulting in graft rejection C36B1.3 C36B1.3 Protein with moderate similarity to S. cerevisiae Rpb3p, which is the third-largest subunit of RNA polymerase II DNA directed RNA polymerase II C36B1.4 pas-4;C36B1.4 Putative alpha-type subunit of 20S proteasome particle proteasome A-type submit C36B1.5 C36B1.5 Protein with high similarity to PRP4-STK-WD splicing factor (human HPRP4P), which is a protein kinase that associates with U4/U6 snRNP and is involved in transcriptional regulation, contains seven WD domains (WD-40 repeats) U4/U6 small nuclear ribonucleoprotein C36B1.6 C36B1.6 Protein of unknown function C36B1.7 C36B1.7 Member of the dihydrofolate reductase family, which catalyze the NADPH-dependent reduction of dihydrofolate to tetrahydrofolate, has moderate similarity to dihydrofolate reductase (human DHFR), which is associated with methotrexate resistance di-hydrofolate reductase C36B1.8 C36B1.8 Protein of unknown function C36B1.9 C36B1.9 Protein containing a C3HC4 type (RING) zinc finger, which may mediate protein-protein interactions Zinc finger, C3HC4 type (RING finger) C36B7.1 C36B7.1 Protein containing a protein kinase domain, has low similarity to P. carinii Cdc2_carinii, which is a cyclin-dependent kinase with a potential role in the cell cycle CDC2/CDC28 subfamily of ser/thr protein kinases C36B7.2 C36B7.2 Protein containing two protein kinase domains, has low similarity to a region of dual-specificity tyrosine phosphorylated and regulated kinase 3 (human DYRK3), which phosphorylates histone H2B and H3 and may function in spermatogenesis CDC2/CDC28 subfamily of ser/thr protein kinases C36B7.3 C36B7.3 Protein of unknown function C36B7.4 C36B7.4 Protein of unknown function C36B7.5 C36B7.5 Protein containing 18 type 1 thrombospondin domains and two PAN domains, has a region of low similarity to properdin P factor (human PFC), which plays a role complement-mediated clearance and natural and acquired resistance to infection type-I thrombospondin TSR repeats C36B7.6 C36B7.6 Protein of unknown function, has a region of high similarity to cleft lip and palate associated transmembrane protein 1 (mouse Clptm1), which is an antigen found on the surface of thymic epithelial cells that plays a role in T cell development C36B7.7 C36B7.7 Protein of unknown function hen-1 encodes a secretory protein that contains a low-density lipoprotein receptor class A domain and affects integration of sensory stimuli and behavioral plasticity; expressed in pharyngeal muscles, the vulva, and is weakly expressed in a subset of neurons. C36C5.1 C36C5.1 Protein of unknown function, has high similarity to uncharacterized C. elegans C36C5.2 C36C5.10 C36C5.10 Protein of unknown function, has high similarity to uncharacterized C. elegans C36C5.6 7TM chemoreceptor, srab family C36C5.11 C36C5.11 Protein of unknown function, has high similarity to uncharacterized C. elegans C36C5.6 7TM chemoreceptor, srab family C36C5.12 C36C5.12 Protein containing a DUF19 domain of unknown function, which contain twelve conserved cysteines, has high similarity to uncharacterized C. elegans T28A11.3 C36C5.13 C36C5.13 Member of the reverse trancriptase family, which are RNA-dependent DNA polymerases, contains a PHD-finger, which may be involved in chromatin-mediated transcriptional regulation C36C5.14 C36C5.14 Protein containing a DUF19 domain of unknown function, which contain twelve conserved cysteines, has high similarity to uncharacterized C. elegans C36C5.15 C36C5.15 C36C5.15 Protein containing a DUF19 domain of unknown function, which contain twelve conserved cysteines, has high similarity to uncharacterized C. elegans C36C5.14 C36C5.2 C36C5.2 Protein of unknown function, has high similarity to uncharacterized C. elegans C36C5.1 7TM chemoreceptor, srab family C36C5.3 C36C5.3 Protein containing two DUF40 domains of unknown function, which contain four conserved cysteines, has high similarity to uncharacterized C. elegans F35F10.9 C36C5.4 C36C5.4 Protein containing a DUF19 domain of unknown function, which contain twelve conserved cysteines, has high similarity to uncharacterized C. elegans T28A11.16 C36C5.5 C36C5.5 Protein containing a DUF19 domain of unknown function, which contain twelve conserved cysteines, has high similarity to uncharacterized C. elegans F10G2.1 C36C5.6 C36C5.6 Protein of unknown function, has high similarity to uncharacterized C. elegans C36C5.11 7TM chemoreceptor, srab family C36C5.7 C36C5.7 Protein of unknown function, has high similarity to uncharacterized C. elegans C36C5.6 7TM chemoreceptor, srab family C36C5.8 C36C5.8 Protein of unknown function, has high similarity to uncharacterized C. elegans C36C5.6 7TM chemoreceptor, srab family C36C5.9 C36C5.9 Protein containing a DUF32 domain of unknown function, has low similarity to uncharacterized C. elegans Y5H2B.7 7TM chemoreceptor, srt family C36C9.1 C36C9.1 Protein of unknown function, has high similarity to uncharacterized C. elegans F52D2.4 C36C9.2 C36C9.2 Protein containing a T-box domain, which bind DNA C36C9.3 C36C9.3 Protein with high similarity to C. elegans T07D3.1, which may function in germ-line stem cell differentiation, contains a DUF38 domain of unknown function and an F-box domain, which links a target protein and a ubiquitin-conjugating enzyme This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins; this gene's encoded protein also contains an FTH/DUF38 motif, which may also mediate protein-protein interaction. C36C9.4 C36C9.4 Putative ortholog of C. elegans T25D1.2 gene product C36C9.5 C36C9.5 Protein with moderate similarity to C. elegans T24E12.9 gene product C36E6.1 C36E6.1 Putative ortholog of C. elegans M01A10.1 gene product C36E6.1 encodes two proteins by alternative splicing, belonging to an ancient family of single-stranded nucleic acid-binding proteins, that are predicted to regulate gene expression through binding either mRNA or (locally) single-stranded DNA; they are most likely to specifically bind one or more discrete mRNAs and regulate their spatial localization or alternative splicing. C36E6.2 C36E6.2 Protein of unknown function C36E6.B mlc-2;C36E6.5;C36E6.B Regulatory myosin light chain, essentially identical to mlc-1 C36E6.F mlc-1;C36E6.3;C36E6.F Regulatory myosin light chain, essentially identical to MLC-2 C36E8.1 C36E8.1 Protein with low similarity to human RRN3, which is an RNA polymerase I transcription factor C36E8.2 C36E8.2 Protein with moderate similarity to C. elegans R01E6.6 gene product C36E8.3 C36E8.3 Protein of unknown function C36E8.4 C36E8.4 Protein containing two coiled-coil domains and an FCH (Fes/CIP4 homology) domain C36E8.5 C36E8.5 Protein with strong similarity to beta tubulin (C. elegans BEN-1), member of the tubulin-FtzA family, which are involved in polymer formation beta tubulin; tbb-2 encodes a homolog of mammalian beta-tubulin (TUBB) that is expressed at high levels in the germline; TBB-2 is redundant for embryonic viability, due to its paralog TBB-1; however, unlike its paralog TBB-1 it is required for normal microtubule severing by the katanin complex MEI-1/MEI-2; TBB-2 is required together with TBB-1, TBA-1, and tba-2 to make spindle structures in embryos and TBB-2 also affects the stability of the PO spindle; first divisions are normal in null mutants, but putative gain-of-function mutations affect centrosome rotations in the P0, P1, and EMS blastomeres of the early embryo, and affect pronuclear migration and meiosis. C36F7.1 C36F7.1 Protein containing a homeobox domain (homeodomain), which are found in transcription factors, has a region of moderate similarity to a region of iroquois related homeobox 1 (mouse Irx1), which is a transcription factor that may serve in heart development Homeobox domain C36F7.2 C36F7.2 Protein containing two ankyrin repeats, which may mediate protein-protein interactions C36F7.4 zig-8;C36F7.3;C36F7.4 Protein containing four immunoglobulin (Ig) domains, has a region of low similarity to a region of limbic system-associated membrane protein (rat Lsamp), which plays a role in the selective outgrowth of neurons and the targeting of axons Drosophila amalgam protein like C36F7.5 C36F7.5 Protein containing a DUF236 domain of unknown function, has strong similarity to uncharacterized C. elegans F42H11.1 C36H8.1 C36H8.1 Protein containing a major sperm protein (MSP) domain, which are involved in sperm motility, has a region of moderate similarity to C. elegans MSP-77, which is involved in oocyte maturation major sperm protein like C36H8.2 opu-6;inx-6;C36H8.2 Member of the integral membrane innexin family, which are involved in the formation of gap junctions, has low similarity to C. elegans INX-3, which is an innexin that forms connexin-like intercellular channels UNC-7 like; inx-6 encodes an innexin, an integral transmembrane channel protein that is a structural component of invertebrate gap junctions; INX-6 is required for formation of pharyngeal gap junctions and thus for the electrical coupling and synchronous muscle contractions necessary for normal feeding behavior and postembryonic development; INX-6 may function redundantly with EAT-5, another C. elegans innexin; INX-6 expression is first detected in embryonic pharyngeal precursors and during later larval and adult stages, in pharyngeal corpus muscles and isthmus marginal cells, where INX-6 localizes to plaque-like structures in the plasma membrane. C36H8.3 flp-9;C36H8.3 KPSFVRF-amide neurotransmitter flp-9 encodes a predicted FMRFamide-like peptide neurotransmitter that inhibits action potentials in the pharyngeal muscle when applied to the pharynx of dissected worms and inhibits movement when injected into A. suum; expressed at highest levels prior to adulthood. C37A2.1 C37A2.1 Protein containing a KH domain, which may bind RNA, has low similarity to etoile (mouse Etle), which is an RNA-binding protein that interacts with the RNA binding protein RBM (mouse RbmY1a1) C37A2.2 C37A2.2 Protein of unknown function, has weak similarity over central region to human NAF1 (Nef-associated factor 1) The protein product of this gene is predicted to contain a glutamine/asparagine (Q/N)-rich ('prion') domain, by the algorithm of Michelitsch and Weissman (as of the WS77 release of WormBase, i.e., in wormpep77). C37A2.3 C37A2.3 Member of the acyl-CoA dehydgrogenase protein family acyl-CoA dehydrogenase C37A2.4 cye-1;evl-10;C37A2.4 Putative cyclin E2, has strong similarity to human and D. melanogaster cyclin E proteins, has similarity to S. cerevisiae Clb proteins cyclin; cye-1 encodes a homolog of the G1 cell cycle regulator cyclin E; CYE-1 is required for progression through the G1 phase of the cell cycle and for endoreduplication in intestinal cells, and is required maternally both for embryonic development and for the proper execution of several post-embryonic lineages (e.g. vulval development); CYE-1 is provided maternally and expressed ubiquitously in nuclei during embryonic development; postembryonic expression is restricted to actively proliferating blast cells, including the germline. C37A2.5 C37A2.5 Protein containing a C2H2 type zinc finger domain, which bind nucleic acids The protein product of this gene is predicted to contain a glutamine/asparagine (Q/N)-rich ('prion') domain, by the algorithm of Michelitsch and Weissman (as of the WS77 release of WormBase, i.e., in wormpep77). C37A2.6 C37A2.6 Protein of unknown function C37A2.7 C37A2.7 Protein of the large 60S ribosomal subunit, has moderate similarity to ribosomal protein large P2 (human RPLP2), which is an acidic ribosomal protein that contains an antigen which generates autoantibodies in individuals with systemic lupus erythematosus ribosomal protein C37A2.8 C37A2.8 Protein of unknown function C37A5.1 C37A5.1 Member of the C. elegans putative membrane protein family 8, has a region of moderate similarity to a region of bestrophin (human VMD2), which plays a role in vision and causes Bests disease, adult vitelliform macular dystrophy, and bull's eye maculopathy Putative membrane protein C37A5.2 C37A5.2 Protein of unknown function, has very strong similarity to uncharacterized C. elegans C37A5.4 C37A5.4 C37A5.4 Protein of unknown function, has very strong similarity to uncharacterized C. elegans C37A5.2 C37A5.7 C37A5.7 Protein of unknown function, has weak similarity to C. elegans F46F11.8 C37A5.8 C37A5.8 Protein of unknown function, has weak similarity to C. elegans C37A5.2 C37A5.9 C37A5.9 Putative ortholog of C. elegans pry-1 gene product C37C3.1 C37C3.1 Protein with strong similarity to C. elegans T24A6.7 gene product C37C3.10 C37C3.10 Protein with moderate similarity to C. elegans F13B6.1 gene product C37C3.11 C37C3.11 Protein of unknown function C37C3.2 C37C3.2 Putative translation initiation factor 5, predicted ortholog S. cerevisiae Tif5p catalyzes hydrolysis of GTP on the 40S ribosomal subunit-initiation complex followed by joining to 60S ribosomal subunit C37C3.3 C37C3.3 Protein of unknown function, has high similarity to uncharacterized C. elegans C56C10.3 C37C3.4 grd-8;C37C3.4 Protein of unknown function, has moderate similarity to C. elegans GRD-6 grd-8 encodes a protein that contains a novel Ground domain. C37C3.6 C37C3.6 Protein containing an immunoglobulin (Ig) domain, 12 type 1 thrombospondin domains and 17 kunitz or bovine pancreatic trypsin inhibitor domains, has a region of low similarity to a region of C. elegans GON-1, which is a metalloprotease protease inhibitor; C37C3.6 encodes three isoforms of a large, novel multidomain glycoprotein orthologous to thrombospondin from Haemonchus contortus, papilin from D. melanogaster, and lacunin from Manduca sexta; the N-terminal region of C37C3.6 proteins have a domain set also found in the C-terminal region of ADAMTS matrix-associated metalloproteinases; C37C3.6 is generally required for normal cell arrangements, being required in embryos for viability and normal hypodermal enclosure, and in L1 larvae for normal excretory canal function. C37C3.7 C37C3.7 Member of the transthyretin-like family, has a region of low similarity to a region of tenascin C (hexabrachion, human TNC), which is a multidomain extracellular matrix glycoprotein that may be involved in cell adhesion and neurite outgrowth C37C3.8 C37C3.8 Protein containing a UPF0103 domain of unknown function, has high similarity to uncharacterized human LOC51072 C37C3.9 C37C3.9 Protein containing a BTB (BR-C, ttk and babor) or POZ (Pox virus and zinc finger) domain, which are found in some DNA and actin binding proteins and may mediate protein-protein interactions C37E2.1 C37E2.1 Member of the isocitrate dehydrogenase (NAD+) protein family isocitrate dehydrogenase; This gene encodes a protein predicted by Eisenberg and coworkers, with 52% accuracy, to be mitochondrial. C37E2.2 C37E2.2 Protein of unknown function, has high similarity to uncharacterized C. elegans C37E2.3 androgen-dependent expressed protein like C37E2.3 C37E2.3 Protein of unknown function, has high similarity to uncharacterized C. elegans C37E2.2 androgen-dependent expressed protein like C37E2.4 ceh-36;C37E2.4 Protein containing a homeobox domain (homeodomain), which are found in transcription factors, has moderate similarity to a region of cone-rod homeobox protein (rat Crx), which is a transcription factor that regulates pineal gland gene expression Homeobox domain; ceh-36 encodes a paired-like homeodomain transcription factor that is one of three orthodenticle (OTD)-like homeodomain proteins in C. elegans (the others being ttx-1 and ceh-37); CEH-36 is required broadly for specification of the AWC olfactory neuron and also for establishing the left-right asymmetry of the ASEL and ASER gustatory neurons; in addition, CEH-36 is sufficient to specify the AFD thermosensory neuron fate in some cell types; CEH-36 is expressed in the AWC and ASE chemosensory neurons. C37E2.5 ceh-37;C37E2.5 Homeodomain transcription factor, has similarity over the homeodomain to many human and D. melanogaster homeodomain transcription factors Homeobox domain; ceh-37 encodes one of three C. elegans proteins with an OTX-like homeodomain; however, CEH-37 lacks other domains found in OTX proteins, and the CEH-37 homeodomain is predicted to resemble the Myb domain of telomere-binding proteins; CEH-37 binds the telomeric sequence 'TTAGGC' if it is repeated at least 1.5 times, and is mainly localized to the telomere in vivo; ceh-37 mutants have a weak increase in chromosomal nondisjunction; CEH-37 is involved in specifying some aspects of the AWB olfactory neuron fate, such as expression of an AWB-specific odorant receptor and a LIM-class homeodomain protein, LIM-4; CEH-37 is expressed broadly in the early embryo, while in larvae and adults it is expressed solely in the excretory cell. C37F5.1 lin-1;C37F5.1 Putative transcription factor with an ETS-domain; involved in cell fate decisions in vulval development and elsewhere lin-1 encodes an Ets-domain-containing transcription factor that is a member of the ETS gene family that includes human ELK1, 3, and 4 (OMIM:600247); LIN-1 functions as a general effector of MAP kinase-mediated signaling; when MAP kinase is inactive, LIN-1 forms a complex with LIN-31/WH that inhibits vulval cell fate specification; upon MAP kinase activation (vulval induction), LIN-1 is phosphorylated, dissociates from LIN-31, and becomes inactive, thus allowing for vulval development. C37H5.1 C37H5.1 Member of the annexin protein family, which exhibit calcium-dependent phospholipid binding, has low similarity to annexin V (human ANXA5), which may be associated with antiphospholipid syndrome, preeclampsia, and systemic lupus erythematosus annexin; nex-4 encodes a predicted annexin. C37H5.10 C37H5.10 Protein of unknown function, has strong similarity to uncharacterized C. elegans C37H5.11 cwp-1 encodes a nematode-specific protein that is coexpressed with lov-1 and pkd-2. C37H5.11 C37H5.11 Protein of unknown function, has strong similarity to uncharacterized C. elegans C37H5.10 cwp-2 encodes a nematode-specific protein that is coexpressed with lov-1 and pkd-2. C37H5.12 C37H5.12 Protein of unknown function C37H5.13 C37H5.13 Member of the Acyl-CoA thioesterase family, which hydrolyze a range of acyl-CoA thioesters, has moderate similarity to peroxisomal acyl-CoA thioesterase 1 (human PTE1), which cleaves thioester bonds on medium chain acyl CoAs and binds HIV Nef protein C37H5.2 C37H5.2 Member of the alpha or beta hydrolase fold family, has weak similarity to S. cerevisiae Ict1p, which is required for normal sensitivity to copper C37H5.3 C37H5.3 Member of the alpha or beta hydrolase fold family, has weak similarity to S. cerevisiae Ecm18p, which may be involved in cell wall structure or biosynthesis C37H5.4 C37H5.4 Protein of unknown function cwp-3 encodes an unfamiliar protein predicted to be secreted and alleged to be coexpressed with polycystins; CWP-3 is dispensable for viability and gross morphology in mass RNAi screens. C37H5.5 C37H5.5 Protein of unknown function, has low similarity to uncharacterized S. pombe Spbc887.03cp C37H5.6 C37H5.6 Protein with high similarity to adenylosuccinate synthetase (human ADSS), which catalyzes the first committed step in the conversion of IMP to AMP in the purine biosynthesis pathway, member of the adenylosuccinate synthetase family adenylosuccinate synthetase C37H5.8 hsp-6;C37H5.8 Member of the heat shock HSP70 protein family heat shock 70 protein; hsp-6 encodes a mitochondrial-specific chaperone that is a member of the DnaK/Hsp70 superfamily of molecular chaperones; hsp-6 is believed to be involved in the mitochondrial unfolded protein response, as hsp-6 expression, normally broadly detected from the L1 larval through adult stages of development, is greatly increased in response to treatments that disrupt mitochondrial protein handling; loss of hsp-6 activity via RNAi results in severe growth defects with arrest at embryonic and early larval stages of development. C37H5.9 C37H5.9 Member of the astacin (M12A) family of metalloproteases, has a region of low similarity to a region of tolloid-like (mouse Tll), which processes probiglycan and appears to facilitate collagen-elastin crosslinking during extracellular matrix biogenesis C38C10.1 tkr-1;C38C10.1 Protein kinase of the TachyKinin Receptor family G protein coupled receptor; tkr-1 encodes a G protein-coupled receptor that is the C. elegans tachykinin-like neuropeptide receptor homolog; by homology, TKR-1 is predicted to function in modulation of excitatory neurotransmission; as loss of tkr-1 activity via RNAi results in moderate reduction of fat content, TKR-1 may play a specific role in regulating lipid metabolism; a tkr-1 reporter gene fusion is reportedly expressed in the socket cells of the deirid and post-deirid sensilla from the L2 larval stage through adulthood. C38C10.2 C38C10.2 Protein with similarity to human and D. melanogaster sodium-dependent inorganic phosphate cotransporters, member of the major facilitator superfamily Sodium/phosphate transporter; C38C10.2 is orthologous to the human gene SOLUTE CARRIER FAMILY 17 (ANION/SUGAR TRANSPORTER), MEMBER 5 (SLC17A5; OMIM:604322), which when mutated leads to disease. C38C10.3 C38C10.3 Protein with strong similarity to C. elegans ZC84.5 gene product C38C10.4 C38C10.4 Protein of unknown function, putative paralog of C. elegans F22B7.5 gpr-2 encodes a protein containing a GPR (G Protein Regulator)/GoLoco motif characteristic of guanine nucleotide exchange factors specific for G-alpha GTPases; GPR-2 appears to function redundantly during early embryogenesis and germ-line development to regulate chromosome and spindle movements during cell division; GPR-2 likely acts as a positive regulator of G protein signaling and specifically, may regulate GOA-1 signaling in the embryo; GPR-2 forms a protein complex with the nearly identical GPR-1 and with LIN-5, a coiled-coil protein that is required for proper localization of GPR-2 to the cell cortex and spindle asters of the early embryo; in addition, proper GPR-2/GPR-1/LIN-5 localization between the P2 and EMS blastomeres at the four-cell stage, which may contribute to spindle positioning in EMS, requires the MES-1/SRC-1 tyrosine kinase signaling pathway; GPR-2 is believed to act downstream of, or in parallel to, PAR-3, a PDZ domain-containing protein, in mitotic spindle positioning in the early embryo. C38C10.5 C38C10.5 Component of the Mediator complex required for transcriptional regulation of certain genes RGR1 (yeast) C38C3.1 C38C3.1 Protein containing a DUF215 domain of unknown function, has high similarity to uncharacterized C. elegans C38C3.2 7TM chemoreceptor, sru family C38C3.2 C38C3.2 Protein containing a DUF215 domain of unknown function, has high similarity to uncharacterized C. elegans C38C3.1 7TM chemoreceptor, sru family C38C3.3 C38C3.3 Protein of unknown function C38C3.4 C38C3.4 Protein containing three protein kinase domains protein kinase C38C3.5 unc-60;let-328;unc-60B;unc-66;C38C3.5 Actin binding protein that regulates the polymerization of actin; similar to mammalian cofilin and destrin actin depolymerizing factor; unc-60 encodes orthologs of actin depolymerizing factor/cofilin, actin-binding proteins that regulate actin filament dynamics; one UNC-60 isoform, UNC-60A, primarily binds G-actin, depolymerizes actin filaments, and inhibits actin polymerization; UNC-60A is essential during early embryonic development for polar body extrusion, cytokinesis, and embryonic patterning; UNC-60B, which does not inhibit actin polymerization, binds F- and G-actin and influences the rate of actin polymerization by the UNC-60B:actin ratio; UNC-60B is required for actin filament organization in body wall muscle, locomotion, and for efficient actin filament disassembly by UNC-78, an actin interactin protein 1 (AIP1) ortholog; UNC-60A and UNC-60B are differentially expressed: UNC-60A is found in oocytes, embryos, and the adult gonad and intestine, while UNC-60B is found in body wall muscle, the vulva, and spermatheca. C38C3.6 C38C3.6 Protein of unknown function C38C3.7 C38C3.7 Member of an uncharacterized protein family C38C3.8 C38C3.8 Putative ortholog of C. elegans Y69E1A.B gene product C38C3.9 C38C3.9 Protein containing nuclear hormone receptor C4-type zinc finger and ligand-binding domains, has low similarity to hepatocyte nuclear factor 4 gamma (mouse Hnf4g), which is involved in differential transcriptional regulation of HNF4-dependent genes zinc finger protein C38C5.1 C38C5.1 Protein of unknown function C38C6.2 C38C6.2 Protein containing one alpha amylase N-terminal catalytic domain, which degrade branched and unbranched starches, has weak similarity to neutral and basic amino acid transporter (mouse Slc3a1), which is a cystine and dibasic amino acid transporter Alpha amylase; atg-2 is orthologous to human SLC3A1 (OMIM:104614, mutated in cystinuria). C38C6.3 C38C6.3 Protein with moderate similarity to C. elegans B0457.2 gene product C38C6.4 C38C6.4 Member of the C. elegans Sre G protein-coupled chemoreceptor family, which are putative chemosensory receptors, has low similarity to uncharacterized C. elegans C42C1.1 7TM receptor, sre family C38C6.5 C38C6.5 Putative ortholog of C. elegans T08B6.5 gene product C38C6.6 C38C6.6 Protein of unknown function C38D4.2 C38D4.1;C38D4.2 Protein of unknown function, has very strong similarity to uncharacterized C. elegans W03G9.3 C38D4.3 C38D4.3 Protein containing an AT-hook motif, which bind DNA with a preference for A-T rich regions C38D4.4 C38D4.4 Putative ortholog of C. elegans F58G11.3 gene product C38D4.5 C38D4.5 Protein containing a WW domain, which bind proline-rich peptide epitopes, a pleckstrin homology (PH) domain, and a RhoGAP (GTPase activator protein) domain, has a region of low similarity to a region of breakpoint cluster region (human BCR) chimaerin C38D4.6 pal-1;ceh-3;nob-2;C38D4.6 Homeodomain transcription factor required for execution of various cell fates, has similarity to human and D. melanogaster caudal-type homeodomain transcription factors homeobox protein (cad subfamily); pal-1 encodes a homeodomain protein that is the C. elegans Caudal ortholog; PAL-1 is required maternally and embryonically for cell fate specification and posterior patterning during embryogenesis; PAL-1 is also required postembryonically for fate specification of the posterior V6 neuroectoblast during male tail development; PAL-1 is expressed in posterior blastomeres beginning at the four-cell stage of embryogenesis and its expression continues during embryogenesis in posterior-derived tissues and cells undergoing movement or forming midline structures; pal-1 is subject to both transcriptional and translational regulation. C38D4.7 C38D4.7 Protein of unknown function C38D4.8 arl-1;C38D4.8 Member of the ADP-ribosylation factor (ARF) family, which are GTP-binding proteins involved in protein trafficking, has moderate similarity to C. albicans Arf1p, which is an ADP-ribosylation factor ADP-ribosylation factor C38D4.9 C38D4.9 Protein with weak similarity to S. cerevisiae YIL064W methylase C38D9.1 C38D9.1 Protein containing a DUF38 domain of unknown function and an F-box domain, which serve as a link between a target protein and a ubiquitin-conjugating enzyme, has a region of low similarity to C. elegans FOG-2 This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins; this gene's encoded protein also contains an FTH/DUF38 motif, which may also mediate protein-protein interaction. C38D9.2 C38D9.2 Protein of unknown function, has high similarity to uncharacterized C. elegans F15D4.5 C38D9.3 C38D9.3 Protein of unknown function, has moderate similarity to uncharacterized C. elegans R09H3.1 C38D9.4 C38D9.4 Has strong similarity to several C. elegans proteins of unknown function C38D9.5 C38D9.5 Protein containing a WSN domain and an ankyrin repeat, which may mediate protein-protein interactions, has low similarity to C. elegans Y67A10A.3 C38D9.6 C38D9.6 Protein of unknown function, putative paralog of C. elegans F47H4.C This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins; this gene's encoded protein also contains an FTH/DUF38 motif, which may also mediate protein-protein interaction. C38D9.7 C38D9.7 Protein of unknown function, putative paralog of C. elegans C38D9.1 This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins; this gene's encoded protein also contains an FTH/DUF38 motif, which may also mediate protein-protein interaction. C38D9.8 C38D9.8 Protein of unknown function, putative paralog of C. elegans F31E9.4 This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins. C38D9.9 C38D9.9 Protein of unknown function, putative paralog of C. elegans F31E9.3 This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins; this gene's encoded protein also contains an FTH/DUF38 motif, which may also mediate protein-protein interaction. C38H2.1 C38H2.1 Protein containing TBC and RUN domains, which are regulators of small GTPases, has a region of low similarity to a region of S. cerevisiae Gyp7p, which is a GTPase-activating protein for Ypt7p Probable rabGAP domains C38H2.2 C38H2.2 Member of the Fringe-like family, which may be involved in controlling the response of the Notch receptor to specific ligands, has high similarity to uncharacterized human C1GALT1, which may be associated with Tn syndrome and IgA nephropathy C39B10.1 C39B10.1 Protein with weak similarity to C. elegans C26F1.6 G-protein coupled receptor C39B10.2 C39B10.2 Protein containing neurotransmitter-gated ion-channel ligand binding and transmembrane domains, has low similarity to rho 1 subunit of the gamma aminobutyric acid A (GABA) receptor (human GABRR1), which is involved in regulation of neuronal sensitivity gamma-aminobutyric-acid receptor C39B10.3 C39B10.3 Protein of unknown function, contains a coiled-coil region, has weak similarity to human p160ROCK (a Rho-associated, coiled-coil containing protein kinase 1) and human KIAA0373 protein C39B10.4 C39B10.4 Protein of unknown function C39B10.5 C39B10.5 Protein of unknown function C39B5.1 C39B5.1 Protein of unknown function, has strong similarity to C. elegans F56D6.5 7TM chemoreceptor, srz family C39B5.10 C39B5.10 Protein of unknown function C39B5.11 C39B5.11 Protein of unknown function, putative paralog of C. elegans Y39A3B.4 7TM chemoreceptor, srd family C39B5.12 C39B5.12 Protein of unknown function, putative paralog of C. elegans H04J21.2 7TM chemoreceptor, srd family C39B5.2 C39B5.2 Protein of unknown function, has moderate similarity to C. elegans C32B5.15 C39B5.3 C39B5.3 Protein of unknown function, has strong similarity to C. elegans T12B5.1 C39B5.4 C39B5.4 Protein of unknown function, has strong similarity to C. elegans ZC47.6 This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins; this gene's encoded protein also contains an FTH/DUF38 motif, which may also mediate protein-protein interaction. C39B5.5 C39B5.5 Protein of unknown function, putative paralog of C. elegans Y51H4A.D C39B5.6 C39B5.6 Protein with moderate similarity to D. melanogaster CG5463 (CG5463 gene product) amidotransferase C39B5.7 C39B5.7 Protein of unknown function, has strong similarity to C. elegans ZC47.4 This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins; this gene's encoded protein also contains an FTH/DUF38 motif, which may also mediate protein-protein interaction. C39B5.8 C39B5.8 Protein of unknown function, has strong similarity to C. elegans C17B7.11 This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins; this gene's encoded protein also contains an FTH/DUF38 motif, which may also mediate protein-protein interaction. C39B5.9 C39B5.9 Protein of unknown function, putative paralog of C. elegans F52D2.8 This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins; this gene's encoded protein also contains an FTH/DUF38 motif, which may also mediate protein-protein interaction. C39D10.1 C39D10.1 Protein of unknown function C39D10.2 C39D10.2 Protein of unknown function C39D10.3 C39D10.3 Protein with similarity to human PCYT2, phosphoethanolamine cytidylyltransferase B. subtilis glycerol-3-phosphate cytidylyltransferase C39D10.5 C39D10.5 Protein of unknown function C39D10.6 C39D10.6 Protein of unknown function, has weak similarity to C. elegans F17H10.2 C39D10.7 C39D10.7 Protein containing 20 chitin binding peritrophin-A domains, has a region of low similarity to C. elegans CEJ-1, which is involved in embryogenesis and morphogenesis similar to C. elegans proteins B0280.5, R02F2.4 and C07G2.1 C39D10.8 C39D10.8 Protein with weak similarity to C. elegans Y105C5B.5 gene product C39E6.1 lon-2;C39E6.1 Protein required for embryonic viability C39E6.2 C39E6.2 Protein of unknown function C39E6.3 C39E6.3 Protein containing a homeobox domain (homeodomain), which are found in transcription factors, has a region of high similarity to a region of H6 homeo box 3 (mouse Hmx3), which is a DNA binding protein required for inner ear vestibular system formation C39E6.4 C39E6.4 Protein of unknown function C39E6.6 npr-1;C39E6.6 G protein-coupled receptor with similarity to H. sapiens and D. melanogaster neuropeptide Y receptors G-protein coupled receptor; npr-1 encodes a predicted G protein-coupled neuropeptide receptor that is homologous to the mammalian neuropeptide Y (NPY) receptor (OMIM:162641) required for regulating anxiety, food consumption, and pain sensation; in C. elegans, NPR-1 is involved in ethological variations of social behavior such as social versus solitary feeding; NPR-1 also affects some aspect of UNC-6/netrin-mediated branching of motor neurons, as strong npr-1 mutations can suppress abnormal migration of ventral nerve cord neurons induced by overexpression of UNC-6 lacking domain C; NPR-1 is expressed predominantly in the nervous system, and particularly in the AQR, PQR, and URX neurons that are exposed to the body fluid. C39E9.1 C39E9.1 Protein of unknown function, has high similarity to uncharacterized C. elegans F49E11.11 testis-specific protein TPX-1 like C39E9.10 C39E9.10 Member of the sugar (and other) transporter family, has high similarity to uncharacterized C. elegans F09A5.1 tetracycline resistance protein like C39E9.11 C39E9.11 Protein containing an N-terminal coiled-coil region, has similarity over C-terminal half to human TPRC (protein involved in a papillary renal cell carcinoma associated translocation) C39E9.11 is orthologous to the human gene PAPILLARY RENAL CELL CARCINOMA (TRANSLOCATION-ASSOCIATED) (PRCC; OMIM:179755), which when mutated leads to disease. C39E9.12 C39E9.12 Protein containing a SAP domain, which may bind DNA C39E9.13 C39E9.13 Putative subunit of replication factor C Human activator 1 38 KD subunit like C39E9.14 dli-1;C39E9.14 Protein of unknown function, has low similarity to a region of cytoplasmic dynein light intermediate chain 1 (rat Lic1), which mediates interaction of pericentrin (mouse Pcnt) with dynein and may act in dynein-mediated intracellular transport and mitosis C39E9.2 C39E9.2 Member of the SCP-like extracellular protein family, has low similarity to a region of acidic epididymal glycoprotein (rat Aeg), which plays a role in sperm-egg fusion and may play a role in sperm development testis-specific protein TPX-1 like C39E9.3 C39E9.3 Protein containing two collagen triple helix repeats, which are found in some extracellular proteins, and a nematode cuticle collagen N-terminal domain, has a region of high similarity to a region of C. elegans SQT-1 collagen C39E9.4 C39E9.4 Member of the SCP-like extracellular protein family, has high similarity to uncharacterized C. elegans F49E11.11 testis-specific protein TPX-1 like C39E9.5 C39E9.5 Member of the SCP-like extracellular protein family, has low similarity to a region of acidic epididymal glycoprotein (rat Aeg), which plays a role in sperm-egg fusion and may play a role in sperm development testis-specific protein TPX-1 like C39E9.6 C39E9.6 Member of the SCP-like extracellular protein family, has high similarity to uncharacterized C. elegans C39E9.5 testis-specific protein TPX-1 like C39E9.7 C39E9.7 Protein of unknown function, has weak similarity to uncharacterized C. elegans C18D1.2 sodium/phosphate transporter C39E9.8 C39E9.8 Protein of unknown function, has low similarity to uncharacterized C. elegans Y105C5.G C39E9.9 C39E9.9 Protein containing two collagen triple helix repeats, which are found in some extracellular proteins, and a nematode cuticle collagen N-terminal domain, has moderate similarity to a region of C. elegans BLI-1 collagen C39F7.1 C39F7.1 Protein of unknown function C39F7.4 C39F7.4 Protein with strong similarity to human RAB1, which is a Ras-related GTP-binding protein involved in vesicle transport, member of the Ras superfamily of GTP binding proteins RAS-related protein; rab-1 encodes an ortholog of the small Ras-like GTPase Rab1; by homology, RAB-1 is predicted to play a role in intracellular vesicle trafficking, and consistent with this broad role, large-scale RNAi screens indicate that rab-1 activity is required for fertility, movement, and survival; in yeast two-hybrid assays, RAB-1 interacts with TIR-1, a C. elegans SARM ortholog that is required for innate immunity; RNAi studies suggest that RAB-1 and TIR-1 likely function in a pathway that controls expression of antimicrobial peptides such as NLP-29 and NLP-31; rab-1 also appears to play a role in regulating polyglutamine protein aggregation, as rab-1(RNAi) animals show premature accumulation of protein aggregates; in situ hybridization studies indicate that rab-1 is broadly expressed, with elevated levels apparent in the germline. C39F7.5 C39F7.5 Protein of unknown function, has a region of weak similarity to human FLJ10648, which is a nuclear protein that stimulates cell proliferation C39H7.1 C39H7.1 Protein containing a protein kinase domain, has low similarity to S. pombe Hhp1p, which is a putative casein kinase I (CKI) required for DNA repair casein kinase C39H7.4 C39H7.4 Protein of unknown function C39H7.5 C39H7.5 Protein of unknown function, has low similarity to uncharacterized C. elegans F40D4.5 7TM chemoreceptor, srsx family C39H7.6 C39H7.6 Protein of unknown function, has high similarity to uncharacterized C. elegans C39H7.7 7TM chemoreceptor, srd family C39H7.7 C39H7.7 Putative ortholog of C. elegans B0547.3 gene product 7TM chemoreceptor, srd family C40A11.1 C40A11.1 Protein containing three meprin and TRAF homology (MATH) domains, has high similarity to uncharacterized C. elegans C46F9.3 C40A11.10 C40A11.10 Protein of unknown function C40A11.2 C40A11.2 Protein containing a K+ channel tetramerization domain, which facilitate assembly of alpha-subunits into functional tetrameric channels, has moderate similarity to uncharacterized C. elegans F22E5.6 C40A11.3 C40A11.3 Protein containing a K+ channel tetramerization domain, which facilitate assembly of alpha-subunits into functional tetrameric channels, has a region of high similarity to a region of NY-REN-45 tumor antigen (human LOC51133) C40A11.4 C40A11.4 Protein containing a K+ channel tetramerization domain, which facilitate assembly of alpha-subunits into functional tetrameric channels, has moderate similarity to uncharacterized C. elegans C40A11.2 C40A11.5 C40A11.5 Member of the protein-tyrosine phosphatase family, which are involved in control of cell growth, proliferation, differentiation and transformation, has weak similarity to a region of mouse Ptpn1, which is a non-receptor type protein tyrosine phosphatase protein-tyrosine phosphatase C40A11.6 C40A11.6 Protein containing a K+ channel tetramerization domain, which facilitate assembly of alpha-subunits into functional tetrameric channels, has high similarity to uncharacterized C. elegans C40A11.7 C40A11.7 C40A11.7 Protein containing a K+ channel tetramerization domain, which facilitate assembly of alpha-subunits into functional tetrameric channels, has high similarity to uncharacterized C. elegans C40A11.6 C40A11.8 C40A11.8 Protein with strong similarity to C. elegans F36H5.4 gene product C40A11.9 C40A11.9 Putative ortholog of C. elegans Y43F4A.2 gene product C40C9.1 twk-4;C40C9.1 Member of the 4 TM potassium channel protein family potassium channel protein C40C9.2 acr-9;C40C9.2 Protein with high similarity to C. elegans ACR-16, which is a nicotinic acetylcholine receptor alpha-1 subunit, contains neurotransmitter-gated ion-channel ligand binding and transmembrane domains acetylcholine receptor; acr-9 encodes a predicted member of the alpha subunit family of nicotinic acetylcholine receptors. C40C9.3 C40C9.3 Protein of unknown function, has low similarity to uncharacterized C. elegans Y57G11B.5 C40C9.4 C40C9.4 Protein of unknown function C40C9.5 C40C9.5 Member of the carboxylesterase type B family, has low similarity to neuroligin I (rat Nlgn1), which is a neuronal cell surface protein and a calcium-dependent cell adhesion molecule that acts as a ligand for the cell surface receptor beta-neurexin Carboxylesterases (2 domains) C40D2.1 C40D2.1 Protein containing two meprin and TRAF homology (MATH) domains, has high similarity to uncharacterized C. elegans C46F9.1 C40D2.2 C40D2.2 Protein containing three meprin and TRAF homology (MATH) domains, has strong similarity to uncharacterized C. elegans ZK250.8 possible trans-splice site at 5004; The C40D2.2 gene encodes a protein closely similar to C46F9.3, which has a meprin-associated Traf homology (MATH) domain and may be involved in apoptosis. C40D2.3 C40D2.3 Protein containing three meprin and TRAF homology (MATH) domains, has high similarity to uncharacterized C. elegans C46F9.3 C40D2.4 C40D2.4 Protein containing a HOX homeodomain, has similarity over homeodomains to D. melanogaster transcription factor EYG (eyegone) C40H1.1 cpb-1;C40H1.1 Member of the RNA recognition motif protein family, required for spermatogenesis Ovarian protein (fly); The cbp-1 gene encodes a cytoplasmic polyadenylation element binding (CPEB) protein homolog involved in two steps of spermatogenesis. C40H1.2 C40H1.2 Member of the lipase class 3 family, which are a subset of lipolytic enzymes that hydrolyze ester linkages of triglycerides, has low similarity to uncharacterized C. elegans Y49E10.R C40H1.3 C40H1.3 Protein of unknown function, has weak similarity to C. elegans F28C6.9 C40H1.4 C40H1.4 Member of the GNS1 or SUR4 family of integral membrane proteins, has low similarity to polyunsaturated fatty acid (PUFA) elongase (C. elegans CEEl01), which contains the condensation activity required for fatty acid elongation Yeast hypothetical YCR34W; The elo-4 gene encodes a paralog of elo-1 and elo-2, each of which encodes a polyunsaturated fatty acid (PUFA) elongase; its function in vivo is unknown. C40H1.5 C40H1.5 Member of the transthyretin-like family, has high similarity to uncharacterized C. elegans T28B4.3 Transthyretin-like family C40H1.6 C40H1.6 Protein of unknown function, has high similarity to uncharacterized human HSPC155 C40H1.7 C40H1.7 Putative ortholog of C. elegans Y49E10.P gene product C40H5.1 C40H5.1 Protein of unknown function, has strong similarity to uncharacterized C. elegans ZC412.7 C40H5.2 C40H5.2 Protein of unknown function C40H5.3 C40H5.3 Putative ortholog of C. elegans D1053.4 gene product C40H5.4 C40H5.4 Protein of unknown function, has low similarity to uncharacterized C. elegans Y45F10D.11 B.subtilis penicillin-binding protein like C40H5.5 ttx-3;C40H5.5 LIM homeodomain transcription factor required late in the differentiation of the AIY interneuron so the interneuron can function in thermosensation; has similarity to LIM homeodomain transcription factors of human and D. melanogaster LIM domain containing proteins (2 domains), homeobox protein (lim subfamily); The ttx-3 gene encodes a LIM homeodomain protein required for function of the thermosensory interneuron AIY. C40H5.6 C40H5.6 Protein of unknown function, has a region of high similarity to C. elegans C18E3.2, which is involved in histogenesis and organogenesis C40H5.7 C40H5.7 Protein with weak similarity to C. elegans mec-9 (protein with EGF-like repeats that is required for touch sensation) EGF-domain protein C41A3.1 C41A3.1 Member of the beta-keto-acyl-ACP synthase (tentative) protein family polyketide synthase; This gene encodes a protein predicted by Eisenberg and coworkers, with 68% accuracy, to be mitochondrial. C41A3.2 C41A3.2 Protein of unknown function C41C4.1 C41C4.1 Protein of unknown function, has low similarity to uncharacterized C. elegans F36D1.8 C41C4.2 sre-2;C41C4.2 Putative G protein-coupled receptor, member of the SRE subfamily of receptors which are expressed in chemosensory neurons, has similarity in the N-terminus to rat and S. cerevisiae tricarboxylate carriers 7TM receptor, sre family C41C4.3 C41C4.3 Protein containing three leucine rich repeats, which mediate protein-protein interactions Leucine Rich Repeat (2 copies) (2 domains) C41C4.4 ire-1;ire1;C41C4.4 Serine/threonine protein kinase and endoribonuclease; putative ortholog of the H. sapiens ERN1/IRE1 and S. cerevisiae Ire1p proteins, which are involved in signaling the unfolded protein response from the endoplasmic reticulum to the nucleus serine/threonine kinase; ire-1 encodes a transmembrane serine/threonine protein kinase and site-specific endoribonuclease orthologous to Saccharomyces cerevisiae inositol-requiring 1 protein kinase (Ire1) and human endoplasmic reticulum-to-nucleus signaling 1 (ERN1, OMIM:604033); IRE-1 is required for the unfolded protein response (UPR) that counteracts cellular stress induced by accumulation of unfolded proteins in the endoplasmic reticulum (ER); in response to ER stress, IRE-1 cleaves xbp-1 mRNA to produce transcriptionally active XBP-1 that positively regulates UPR gene expression in order to maintain ER homeostasis. C41C4.5 unc-105;C41C4.5 Member of the amiloride-sensitive sodium channel family, the degenerin family and DEG/ENaC superfamily of proteins Amiloride-sensitive sodium channel; unc-105 encodes a muscle degenerin, a mechanosensory membrane channel that is a member of the degenerin ion channel superfamily and similar to subunits of the mammalian amiloride-sensitive epithelial sodium channel (ENaC, OMIM:600761); UNC-105 is required for normal growth and for normal contraction and organization of muscle, where it is expressed; UNC-105 interacts with LET-2, an alpha2 chain of type IV collagen that is also expressed by muscle and localized to the basement membrane between muscle and hypodermis. C41C4.6 C41C4.6 Protein containing a ubiquitin-like protein-specific protease (Ulp1) family C-terminal catalytic domain, which may bind other protein domains C41C4.7 C41C4.7 Protein of unknown function, has a region of high similarity to a region of cystinosin (human CTNS), which is a lysosomal membrane protein that may be involved in the lysosomal transport of cystine C41C4.7 encodes an ortholog of the human cystinosin gene (CTNS; OMIM:606272, which when mutated leads to nephropathic cystinosis (OMIM:219800); sequence analysis suggests that cystinosin is an integral lysosomal membrane protein. C41C4.8 C41C4.8 Member of the ATPases associated with various cellular activities (AAA) family P97 protein C41D11.1 C41D11.1 Protein of unknown function C41D11.2 C41D11.2 Putative translation initiation factor, protein with strong similarity to human EIF3S3, translation initiation factor eIF3 p40 subunit C41D11.3 C41D11.3 Putative ortholog of C. elegans C41D11.4 gene product C41D11.4 C41D11.4 Putative ortholog of C. elegans C41D11.3 gene product C41D11.5 C41D11.5 Putative mitochondrial endonuclease, predicted S. cerevisiae ortholog Nuc1p has both DNAase and RNase activity C41D11.6 C41D11.6 Protein with strong similarity to C. elegans K08D10.5 gene product C41D11.7 C41D11.7 Member of the DEAD or DEAH box ATP-dependent RNA helicase family, has low similarity to S. cerevisiae Hcs1p, which is DNA helicase A and a Dom34p-interacting protein DNA-binding protein C41D11.8 cps-6;C41D11.8 Mitochondrial Endonuclease G involved in DNA degradation during apoptosis C41D11.9 C41D11.9 Protein with moderate similarity to C. elegans C02F5.3 gene product C41D7.1 C41D7.1 Protein of unknown function C41D7.2 ptr-3;C41D7.2 Member of an uncharacterized protein family ptr-3 encodes a member of the Patched superfamily. C41G11.1 C41G11.1 Protein of unknown function C41G11.2 C41G11.2 Protein of unknown function C41G11.3 rgs-6;C41G11.3 Protein containing a regulator of G protein signaling domain, has low similarity to a region of regulator of G protein signaling 12 (human RGS12), which binds to G protein alpha i subunits and stimulates their intrinsic GTPase activity rgs-6 encodes a regulator of G protein signaling; by homology, RGS-6 is predicted to function as a GTPase-activating protein that binds G protein alpha subunits and negatively regulates heterotrimeric G protein signaling; loss of rgs-6 activity via RNAi or a deletion mutation results in no obvious defects, and likewise, rgs-6 overexpression has no measurable effect on egg-laying behavior, locomotion, or viability; the rgs-6 expression pattern has not yet been reported. C41G11.4 C41G11.4 Protein with moderate similarity to C. elegans H22D07.1 gene product G-protein coupled receptor C41G6.1 C41G6.1 Member of the cytochrome P450 family, has low similarity to cytochrome P450 subfamily IIC (mephenytoin 4-hydroxylase) polypeptide 8 (human CYP2C8), which is a monooxygenase that metabolizes steroids, fatty acids, and xenobiotics cytochrome P450 C41G6.10 C41G6.10 Member of the 7-transmembrane chemoreceptor family of G protein-coupled receptors (GPCR), has high similarity to uncharacterized C. elegans C41G6.14 7TM chemoreceptor, sri family C41G6.11 C41G6.11 Member of the 7-transmembrane chemoreceptor family of G protein-coupled receptors (GPCR), has high similarity to uncharacterized C. elegans C41G6.10 7TM chemoreceptor, sri family C41G6.12 C41G6.12 Protein of unknown function, has very strong similarity to uncharacterized C. elegans Y75B12B.9 C41G6.13 C41G6.13 Protein of unknown function, has very strong similarity to uncharacterized C. elegans Y75B12B.8 C41G6.14 C41G6.14 Protein of unknown function, putative paralog of C. elegans C41G6.10 7TM chemoreceptor, sri family C41G6.15 C41G6.15 Protein of unknown function, putative paralog of C. elegans C41G6.3 7TM chemoreceptor, srw family C41G6.2 C41G6.2 Protein with strong similarity to C. elegans C41G6.3 gene product 7TM chemoreceptor, srw family C41G6.3 C41G6.3 Protein of unknown function, has high similarity to uncharacterized C. elegans C41G6.8 7TM chemoreceptor, srw family C41G6.5 C41G6.5 Protein containing a nuclear hormone receptor C4-type zinc finger domain, has a region of moderate similarity to a region of estrogen-related receptor gamma (mouse Esrrg), which binds to DNA at estrogen response elements and activates transcription Zinc finger, C4 type (two domains) C41G6.6 C41G6.6 Member of an uncharacterized protein family C41G6.7 C41G6.7 Protein of unknown function, has moderate similarity to uncharacterized C. elegans T10H4.6 7TM chemoreceptor, srw family C41G6.8 C41G6.8 Protein of unknown function, has high similarity to uncharacterized C. elegans C41G6.3 7TM chemoreceptor, srw family C41G6.9 C41G6.9 Member of the 7-transmembrane chemoreceptor family of G protein-coupled receptors (GPCR), has moderate similarity to uncharacterized C. elegans Y60A3A.3 C41G7.1 CeSMN;C41G7.1;SMN Ortholog of human SMN, survival motor neuron, a gene associated with spinal muscular atrophy in humans Human muscular atrophy protein like; smn-1 encodes a homolog of human SMN, which when mutated leads to spinal muscular atrophy (OMIM:253300). C41G7.2 klp-16;CeKLP-16;C41G7.2 C-terminal motor kinesin that is required for appropriate spindle assembly in the germ line and likely functions in chromosome movement during early development kinesin, kinesin-14 family; klp-16 encodes a C-terminal motor kinesin orthologous to the Drosophila melanogaster Ncd and Saccharomyces cerevisiae Kar3; however KLP-16 along with KLP-3, KLP-15 and KLP-17 form an unique subgroup based on amino acid sequence and secondary structure analysis; klp-16 is involved in development of the nervous system in embryos and in chromosome segregation; in situ RNA hybridization experiments indicate that klp-16 is localized in the anterior nervous system in the head region of late embryos. C41G7.3 C41G7.3 Member of the tryptophan-rich sensory protein (TspO) and mitochondrial peripheral benzodiazepine receptor (MBR) family, has a region of low similarity to peripheral-type benzodiazepine receptor (mouse Bzrp), which binds benzodiazepines and isoquinolines C41G7.4 C41G7.4 Protein containing a SET domain, which are involved in protein-protein interactions, has a region of low similarity to a region of S. pombe Clr4p, which is a protein required for mating-type locus and centromeric silencing Drosophila SU(VAR)3-9 protein like C41G7.5 ahr-1;C41G7.5 Putative aryl-hydrocarbon receptor; member of the basic helix-loop-helix DNA-binding domain family aryl hydrocarbon (AH) receptor; ahr-1 encodes an aryl hydrocarbon receptor (ligand-activated basic helix-loop-helix transcription factor) ortholog that biochemically resembles its vertebrate relatives (OMIM:600253) which mediate the carcinogenic and teratogenic effects of environmental toxins; AHR-1 binds HSP90 tightly, and forms a dimer with AHA-1 that binds DNA fragments containing the mammalian xenobiotic response element; AHR-1 is expressed in neurons, and may play a role in neuronal migration. C41G7.6 C41G7.6 Protein with weak similarity to C. elegans Y113G7B.12 gene product C41G7.7 C41G7.7 Protein of unknown function C41H7.1 C41H7.1 Protein of unknown function C41H7.2 C41H7.2 Protein containing an F-box domain, which serve as a link between a target protein and a ubiquitin-conjugating enzyme This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins; its encoded protein also contains a Pfam-B45 motif of presently unknown function. C41H7.3 C41H7.3 Protein of unknown function, has moderate similarity to uncharacterized C. elegans C41H7.6 C41H7.4 C41H7.4 Protein of unknown function, has high similarity to uncharacterized C. elegans C41H7.5 C41H7.5 C41H7.5 Protein of unknown function, has high similarity to uncharacterized C. elegans C41H7.6 C41H7.6 C41H7.6 Protein of unknown function, has high similarity to uncharacterized C. elegans C41H7.5 C41H7.7 C41H7.7 Member of the C-type lectin protein family C42C1.1 C42C1.1 Member of the C. elegans Sre G protein-coupled chemoreceptor family, which are putative chemosensory receptors, has low similarity to uncharacterized C. elegans Y39C12A.6 7TM chemoreceptor, sre family C42C1.10 C42C1.10 Member of the mitochondrial carrier protein family of membrane transporters, has moderate similarity to human SLC25A19, which is a nucleotide transporter mitochondrial carrier protein; This gene encodes a protein predicted by Eisenberg and coworkers, with 52% accuracy, to be mitochondrial. C42C1.11 AP-1;C42C1.11 Arginine aminopeptidase of the M1 family of metalloexopeptidases peptidase C42C1.12 C42C1.12 Protein of unknown function C42C1.13 C42C1.13 Protein of unknown function C42C1.14 C42C1.14 Protein of unknown function rpl-34 encodes a large ribosomal subunit L34 protein that affects growth and body coloration. C42C1.15 C42C1.15 Protein of unknown function C42C1.16 C42C1.16 Putative ortholog of C. elegans F47B8.10 gene product C42C1.2 C42C1.2 Member of the protein phosphatase 2C family, which are Mg2+ dependent protein serine and threonine phosphatases, has low similarity to uncharacterized human KIAA1157 protein phosphatase C42C1.3 C42C1.3 Protein of unknown function C42C1.4 C42C1.4 Protein of unknown function, has weak similarity to uncharacterized human KIAA0804 C42C1.5 C42C1.5 Protein with high similarity to mannose-1-phosphate guanylyltransferase (S. cerevisiae Psa1p), which is a GDP-mannose pyrophosphorylase, member of the nucleotidyl transferase family, contains four bacterial transferase hexapeptide (four repeats) domains guanyltransferase C42C1.6 C42C1.6 Protein of unknown function C42C1.7 C42C1.7 Putative G protein-coupled receptor, member of a subfamily with distant similarity to members of the SRG subfamily, no homolog found in human or D. melanogaster C42C1.8 C42C1.8 Putative paralog of C. elegans B0416.5 gene product C42C1.9 C42C1.9 Protein with strong N-terminal similarity to human Hs.125849 and Hs.196610 gene products C42D4.1 C42D4.1 Protein of unknown function, has weak similarity to C. elegans C32H11.6 C42D4.11 C42D4.11 Protein containing a C-type lectin domain, which mediate calcium-dependent carbohydrate recognition, has high similarity to uncharacterized C. elegans Y116A8A.8 C42D4.13 C42D4.13 Protein of unknown function C42D4.2 C42D4.2 Member of the carboxylesterase type B family, has a region of low similarity to esterase 2 (rat Es2), which catalyzes hydrolysis of a variety of carboxylic esters including the anti-cholesteraemic agent clofibrate and may have a role in lipid metabolism esterase C42D4.3 C42D4.3 Protein containing a DB module domain, has high similarity to uncharacterized C. elegans F35B3.4 C42D4.4 C42D4.4 Member of the 7-transmembrane chemoreceptor family of G protein-coupled receptors (GPCR), has weak similarity to C. elegans ODR-10, which is involved in odorant response 7TM chemoreceptor, str family C42D4.5 str-1;C42D4.5 Member of the 7-transmembrane chemoreceptor family of G protein-coupled receptors (GPCR), has low similarity to C. elegans ODR-10, which is involved in odorant response 7TM chemoreceptor, str family C42D4.6 C42D4.6 Member of the Skp1 family, which are needed for targeted protein degradation during the cell cycle, has a region of low similarity to a region of S. cerevisiae Skp1p, which is a component of Cbf3 kinetochore complex and SCF (Skp1p-cullin-F-box) complexes The skr-16 gene encodes a homolog of Skp1 in S. cerevisiae that has no known function in vivo, since skr-16(RNAi) animals are at least superficially normal. C42D4.8 rpc-1;C42D4.8 Member of the RNA polymerase protein family DNA-directed RNA polymerase II largest subunit C42D4.9 str-220;C42D4.9 Member of the 7-transmembrane chemoreceptor family of G protein-coupled receptors (GPCR), has moderate similarity to uncharacterized C. elegans C07G3.3 7TM chemoreceptor, str family C42D8.1 C42D8.1 Protein of unknown function C42D8.2 vit-2;yp170B;C42D8.2 170 kDa yolk protein vitellogenin; The vit-2 gene encodes the vitellogenin homolog YP170. C42D8.3 uvt-3;C42D8.3 Protein of unknown function, has a region of moderate similarity to a region of S. cerevisiae Ydr531p, which is a putative pantothenate kinase involved in coenzyme A biosynthesis C42D8.4 C42D8.4 Protein containing an ETS domain, which bind promoter DNA, has a region of strong similarity to a region of pet-1 transcription factor (rat Rn.9775), which may function in the differentiation and maintenance of serotonergic neurons DNA-binding protein C42D8.5 C42D8.5 Putative angiotensin converting enzyme, putative ortholog of H. sapiens DCP1 gene product [dipeptidyl carboxypeptidase 1 (angiotensin I converting enzyme) (GenBank)] peptidase; acn-1 encodes an ACE-like protein required for larval development and adult morphogenesis, and probably for cell fusion in larval seam cells; ACN-1 lacks not only the HExxH consensus metallopeptidase motif, but also other active site residues found in the sequence HEAI/VxD of mammalian and insect ACEs; acn-1 is expressed in hypodermal cells, vulval precursor cells, and ray papillae in the male tail; the hypodermal expression of acn-1 appears to be controlled by nhr-23 and nhr-25. C42D8.8 uvt-4;apl-1;C42D8.8 Protein containing an amyloid A4 extracellular domain, which is found in Alzheimer's disease-associated APP protein, has low similarity to amyloid beta precursor protein (mouse App), which is a cell surface protease inhibitor that reduces copper apl-1 is orthologous to human AMYLOID BETA A4 PRECURSOR PROTEIN (APP; OMIM:104760), which when mutated leads to familial Alzheimer disease or cerebroarterial amyloidosis; APL-1 contains a copper-binding domain and is required for progession past the L1 larval stage, presumably because it is also required for pharyngeal pumping; apl-1 genetically interacts with feh-1 to affect pharyngeal pumping, and interacts with the PTB2 domain of FEH-1 in vitro. C43C3.1 C43C3.1;ife-1 Protein containing an intermediate filament tail domain intermediate filament protein; ifp-1 encodes a nonessential intermediate filament protein; IFP-1 is predicted to function as a structural component of the cytoskeleton; IFP-1 has no obvious function in RNAi assays. C43C3.2 C43C3.2 Member of the rhodopsin family of G protein-coupled receptors (GPCR), has low similarity to somatostatin receptor 5 (rat Sstr5), which inhibits adenylyl cyclase and mediates inhibitory effects of somatostatin (rat Sst) on cell proliferation and secretion G protein coupled receptor C43C3.3 C43C3.3 Protein containing a zona pellucida domain, which may be a receptor-like glycoprotein dyf-8 encodes a protein predicted to form a cell-surface ligand with a zona pellucida domain; DYF-8 is required for permeability of amphid and phasmid neurons to external dyes, chemotaxis to ammonium chloride, avoidance of high osmotic stimuli, male mating, and dauer formation. C43D7.2 C43D7.2 Protein containing an F-box domain, which serve as a link between a target protein and a ubiquitin-conjugating enzyme, has high similarity to uncharacterized C. elegans F55C9.9 This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins. C43D7.4 C43D7.4 Protein of unknown function, has high similarity to uncharacterized C. elegans C43D7.5 C43D7.5 C43D7.5 Protein of unknown function, has high similarity to uncharacterized C. elegans C43D7.4 C43D7.6 C43D7.6 Protein of unknown function, putative paralog of C. elegans Y116F11.J This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins. C43D7.7 C43D7.7 Protein of unknown function C43D7.8 C43D7.8 Protein of unknown function, has strong similarity to C. elegans Y116F11.I This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins. C43E11.1 C43E11.1 Protein containing a SAP domain, which may bind DNA, and an RNA recognition motif (RRM, RBD, or RNP), has low similarity to a region of apoptotic chromatin condensation inducer in nucleus (mouse Acinus), which induces apoptotic chromatin condensation C43E11.10 C43E11.10 Protein containing an AT-hook motif, which bind DNA with a preference for A-T rich regions, has low similarity to cell division cycle 6 (human CDC6), which is involved in DNA replication initiation cdc-6 encodes a homolog of an origin complex component (CDC6) which in yeast controls the start of DNA replication, and also has a distant paralog (Y39A1A.12) within the C. elegans genome; CDC-6 is superficially dispensable for embryonic viability, perhaps because of redundancy with Y39A1A.12. C43E11.11 C43E11.11 Protein with weak similarity to Golgi transport complex 90 kDa (human GOLTC1), which is a subunit of the Golgi transport complex that is associated with the Golgi and stimulates intra-Golgi transport C43E11.2 C43E11.2 Protein containing an ERCC4 domain, which may modify DNA, has a region of low similarity to a region of S. pombe Mus81p, which is a holliday junction resolvase subunit that associates with S. pombe Eme1p C43E11.3 C43E11.3 Protein containing a SET domain, which are involved in protein-protein interactions, and a WW domain, has a region of low similarity to a region of huntingtin interacting protein B (human HYPB), which binds normal and mutant Huntingtin protein C43E11.3 is orthologous to human NUCLEAR RECEPTOR-BINDING Su-var, ENHANCER OF ZESTE, AND TRITHORAX DOMAIN PROTEIN 1 (NSD1; OMIM:606681), which when mutated leads to sporadic Sotos syndrome (OMIM:117550). C43E11.4 C43E11.4 Protein containing an elongation factor Tu GTP binding domain, an elongation factor Tu domain 2, and an elongation factor Tu C-terminal domain, has moderate similarity to mitochondrial translation elongation factor Tu (S. cerevisiae Tuf1p) elongation factor Tu C43E11.5 C43E11.5 Member of the protein-tyrosine phosphatase family, which are involved in control of cell growth, proliferation, differentiation and transformation, has very strong similarity to uncharacterized C. elegans C50F2.5 C43E11.6 C43E11.6 Protein containing three PDZ, DHR, or GLGF domains and three SAM (sterile alpha motif) domains, has low similarity to a region of neural tissue-specific F-actin binding protein (neurabin, rat LOC84685), which cross-links actin filaments nab-1 encodes a PDZ and SAM domain-containing protein that is the sole C. elegans ortholog of the mammalian Neurabin/Spinophilin proteins; by homology, NAB-1 is predicted to interact with F-actin, ZYG-8/Doublecortin and the SAD-1 serine/threonine kinase to regulate interactions between the actin and microtubule networks during cell migration, growth cone guidance, and cell division; loss of nab-1 activity via RNAi has been reported to result in early embryonic lethality, dumpy and left-handed roller animals, as well as abnormalities in germ-line development and vulval morphogenesis; in large-scale screens, nab-1 RNAi did not result in any obvious abnormalities; NAB-1 translational reporter fusions show expression in hypodermal cells, neurons, and muscle. C43E11.7 C43E11.7 Protein containing a mutT domain ndx-7 encodes a NUDIX hydrolase; by sequence comparison, NDX-7 is predicted to function as a pyrophosphatase, and is most closely related to the mouse RP2 protein that has unknown substrate specificity but is regulated transcriptionally by the presence of androgens; in C. elegans, loss of ndx-7 activity via RNA-mediated interference (RNAi) does not result in any obvious abnormalities, consistent with the proposed nonessential roles for Nudix proteins in eliminating potentially toxic nucleotide metabolites from cells and modulating levels of metabolic intermediates by shuttling them into alternative biochemical pathways. C43E11.8 C43E11.8 Member of the Exo70 exocyst complex subunit family, has weak similarity to exocyst component protein 70 kDa homolog (rat Exo70), which is involved in exocytic vesicle targeting and neuronal differentiation and outgrowth C43E11.9 C43E11.9 Putative ortholog of S. cerevisiae Nip7p, a nucleolar protein required for efficient 60S ribosome subunit biogenesis C43F9.4 C43F9.4 Protein of unknown function C43F9.5 C43F9.5 Protein of unknown function, has low similarity to uncharacterized C. elegans F46E10.B C43F9.6 C43F9.6 Member of the Na+,K+ ATPase beta subunit family, which regulate the number of sodium pumps transported to the plasma membrane, has low similarity to C. elegans C17E4.9p Sodium and potassium ATPases C43F9.7 C43F9.7 Protein of unknown function C43G2.1 C43G2.1 Member of the uncharacterized protein family (Hly-III or UPF0073), which may be hemolysins C43G2.2 C43G2.2 Protein with strong similarity to human Bicaudal D homolog 1 (BICD1) and D. melanogaster (BicD) Bicaudal-D, a cytoskeleton-associated protein required for the correct sorting of mRNAs during oogenesis and embryogenesis cytoskeleton-like protein C43G2.3 C43G2.3 Protein of unknown function C43G2.4 C43G2.4 Member of the C. elegans putative membrane protein family 8, has moderate similarity to a region of bestrophin (human VMD2), which plays a role in vision and is associated with Bests disease, adult vitelliform macular dystrophy, and bull's eye maculopathy C43G2.5 C43G2.5 Protein with moderate similarity to human serine proteases; may be anchored to the membrane of a secretory vesicle or the Golgi apparatus peptidase C43H6.1 C43H6.1 Protein of unknown function C43H6.2 C43H6.2 Protein of unknown function C43H6.3 C43H6.3 Protein containing two ankyrin (Ank) repeats, which may mediate protein-protein interactions, has moderate similarity to granule cell differentiation protein (myotrophin, rat Gcdp), which binds to NF-kappa B in vitro and may be involved in transcription C43H6.4 C43H6.4 Protein of unknown function C43H6.5 C43H6.5 Protein containing a C-type lectin domain, which mediate calcium-dependent carbohydrate recognition C43H6.6 C43H6.6 Protein containing a CUB domain, which often occurs extracellularly in developmentally regulated proteins C43H6.7 C43H6.7 Protein containing a DHHC-type zinc finger (NEW1) domain, has a region of low similarity to a region of S. cerevisiae Erf2p, which is involved in palmitoylation and localization of S. cerevisiae Ras2p C43H6.8 C43H6.8 Protein containing one helix-loop-helix DNA-binding domain, which mediate protein dimerization C43H6.9 glr-7;C43H6.9 Protein containing a ligand-gated ion channel domain, which are found in ionotropic glutamate receptors and NMDA receptors, has low similarity to a region of kainate-selective ionotropic glutamate receptor (rat Grik1), which acts in neurotransmission glutamate receptor; glr-7 encodes a protein containing a ligand-gated ion channel domain and is a predicted non-NMDA type ionotropic glutamate receptor; expressed in the pharyngeal nervous system. C43H8.1 C43H8.1 Protein of unknown function C43H8.2 C43H8.2 Protein of unknown function, has low similarity to uncharacterized human MAF1 C43H8.3 C43H8.3 Protein containing an extracellular laminin G domain C44B11.1 C44B11.1;FAIM Protein with high similarity to fas apoptotic inhibitory molecule (mouse Faim), which inhibits Fas (mouse Tnfrsf6)-mediated poly-ADP ribose polymerase (mouse Adprt1) cleavage and apoptosis and that may play a role in lymphocyte homeostasis C44B11.3 mec-12;C44B11.3 Alpha tubulin required in mechanosensory neurons; putative ortholog of S. cerevisiae TUB3 gene product [Tubulin alpha-3 chain, non-essential] alpha tubulin; mec-12 encodes a novel C. elegans alpha-tubulin that is unique amongst C. elegans alpha tubulins in that it may be subject to post-translational acetylation; MEC-12 is required for normal mechanosensory response to gentle touch, and specifically for formation of the 15-protofilament microtubule bundle present in the touch receptor neurons; mec-12 interacts genetically with mec-5, which encodes a unique C. elegans collagen secreted by the hypodermis; MEC-12 is highly expressed in the touch neurons as well as in several other neurons that do not contains the microfilament bundle, such as the ventral cord motorneurons. C44B11.4 C44B11.4 Protein of unknown function C44B12.1 C44B12.1 Protein of unknown function C44B12.2 ost-1;SPARC;C44B12.2 Calcium binding protein that may be secreted osteonectin C44B12.3 C44B12.3 Protein of unknown function C44B12.4 C44B12.4 Putative ortholog of C. elegans Y55F3AM.2 gene product 7TM chemoreceptor, srx family C44B12.5 C44B12.5 Protein of unknown function C44B12.6 C44B12.6 Protein with strong similarity to C. elegans T22H6.1 gene product C44B12.7 C44B12.7;ost-1 Member of the reverse transcriptase protein family, which are RNA-dependent DNA polymerases, has strong similarity to uncharacterized C. elegans Y51H4A.14 reverse transcriptase C44B7.1 p27;C44B7.1 Putative non-ATPase subunit of 19S proteasome particle C44B7.10 C44B7.10 Member of the adenosine and AMP deaminase and cetyl-CoA hydrolases or transferase families, has a region of low similarity to a region of S. cerevisiae Ach1p, which is an acetyl-CoA hydrolase involved in acetate utilization and sporulation C44B7.11 C44B7.11 Member of the M20, M25, or M40 peptidase family of zinc metalloproteases, has low similarity to uncharacterized C. elegans B0495.7 C44B7.2 C44B7.2 Protein containing six RNA recognition motifs (RRM, RBD, or RNP), has moderate similarity to heterogeneous nuclear ribonucleoprotein L (human HNRPL), which binds RNA and may regulate the stability of human VEGF and the translation of hepatitis C virus RNA C44B7.3 C44B7.3 Protein of unknown function, has low similarity to uncharacterized C. elegans C26D10.5 C44B7.4 C44B7.4 Protein of unknown function C44B7.5 C44B7.5 Protein of unknown function C44B7.6 C44B7.6 Member of the transmembrane amino acid transporter (permease) family, has low similarity to lysosomal amino acid transporter 1 (rat Lyaat1), which transports small neutral amino acids and may export them from neuronal lysosomes C44B7.7 C44B7.7 Protein of unknown function, has similarity to human Hs.12770, PAC clone DJ0777023 C44B7.8 C44B7.8 Protein with high similarity to ATP-binding cassette subfamily D (ALD) member 3 (human ABCD3), which mediates peroxisomal import of fatty acids and fatty acyl-CoAs and is associated with Zellweger syndrome, member of the ATP-binding cassette superfamily ATP-binding protein C44B7.9 C44B7.9 Protein with high similarity to ATP-binding cassette subfamily D member 3 (human ABCD3), which mediates peroxisomal import of fatty acids and fatty acyl-CoAs and is associated with Zellweger syndrome, member of the ABC transporter family peroxisomal membrane protein (PMP70, an ATP-binding transport protein) C44B9.1 C44B9.1 Protein of unknown function C44B9.2 C44B9.2 Protein of unknown function C44B9.3 C44B9.3 Protein with moderate similarity to C. elegans C05B5.4 gene product C44B9.4 C44B9.4 Protein with putative PHD fingers S.pombe hypothetical protein C27F7.07C like C44B9.5 C44B9.5 Protein containing an F-box domain, which serve as a link between a target protein and a ubiquitin-conjugating enzyme This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins. C44C1.1 C44C1.1 Protein of unknown function C44C1.2 C44C1.2 Protein of unknown function, has low similarity to uncharacterized C. elegans R09B5.12 C44C1.3 ncs-1;Ce-ncs-1;C44C1.3 Involved in the sensory integration of food and temperature signals, inhibits rhodopsin phosphorylation in a calcium-dependent manner EF-hand calcium binding proteins; The ncs-1 gene encodes a neuronal calcium sensor protein that, along with calcium, is essential for thermotaxis along isothermal paths in thermal gradients. C44C1.4 C44C1.4 Protein with high similarity to vacuolar protein sorting 45 (mouse Vps45), which binds the SNARE syntaxin 6 (mouse Stx6) and may be involved in vesicle transport, member of the Sec 1 family, which may be involved in secretion yeast vacuolar protein sorting protein 33 (SLP1) C44C1.5 C44C1.5 Protein with weak similarity to alcohol acyl transferase (S. cerevisiae Eht1p), which produces ethylhexanate from ethanol and hexanoyl-CoA C44C10.1 C44C10.1 Protein containing two collagen triple helix repeats, which are found in some extracellular proteins, and a nematode cuticle collagen N-terminal domain, has moderate similarity to C. elegans DPY-7, which is a cuticle collagen collagen C44C10.10 C44C10.10 Protein with weak similarity to C. elegans C44C10.4 DNA repair protein RECN like C44C10.2 C44C10.2 Member of the cytochrome P450 family, has a region of low similarity to cytochrome P450 4B1 (mouse Cyp4b1), which is a cytochrome that converts several compounds to active carcinogens and may function in chemical carcinogenesis in extrahepatic tissues C44C10.3 C44C10.3 Member of the sugar (and other) transporter family, has low similarity to a region of solute carrier family 22 member 3 (mouse Slc22a3), which regulates monoamine transport in the heart and placenta Sugar (and other) transporters C44C10.4 C44C10.4 Putative coiled-coil protein, has similarity to S. cerevisiae Smc1p, a protein involved in chromosome condensation and segregation chromosome segregation protein like C44C10.5 C44C10.5 Protein of unknown function, has similarity to C. elegans C44C10.4 chromosome segregation protein like C44C10.6 C44C10.6 Protein of unknown function C44C10.7 C44C10.7 Protein containing a protein kinase domain, has moderate similarity to uncharacterized C. elegans K08H2.5 serine/threonine kinase C44C10.8 C44C10.8 Protein containing one helix-loop-helix DNA-binding domain, which mediates protein dimerization Helix-loop-helix DNA-binding domain; hnd-1 encodes a Hand bHLH transcription factor required for normal viability, gonadogenesis, and posterior body morphology; HND-1 is required for the formation of both somatic gonadal precursors and primordial germ cells, but not for later gonadogenesis; HND-1 is expressed embryogenesis in embryonic mesodermal precursor cells generating (mostly) body wall muscle, in somatic gonad precursor cells, and in some unidentified head cells; the primary defect in hnd-1 mutants may be, nonautonomously, in mesodermal precursor cells; somatic gonad precursor cells are normally generated in hnd-1 mutants, but not maintained. C44C10.9 C44C10.9 Protein of unknown function C44C11.1 ras-1;ras1;C44C11.1 Protein with high similarity to human RRAS2, which is a small GTP-binding RAS-related GTPase that can trigger malignant transformation of breast epithelial cells upon overexpression, member of the Ras superfamily of GTP binding proteins RAS-related protein; ras-1 is orthologous to the human gene UNKNOWN (PROTEIN FOR MGC:21928) (RRAS2; OMIM:600098), which when mutated leads to disease. C44C11.2 C44C11.2 Protein with weak similarity to C. elegans K04C1.2 gene product C44C3.1 C44C3.1 Protein of unknown function, has high similarity to uncharacterized C. elegans C44C3.5 7TM chemoreceptor, srw family C44C3.10 C44C3.10 Putative ortholog of C. elegans C44C3.6 gene product C44C3.2 C44C3.2 Protein of unknown function, has strong similarity to uncharacterized C. elegans H27D07.1, which is predicted to be a G protein-coupled receptor 7TM chemoreceptor, srw family C44C3.3 C44C3.3 Protein of unknown function, has strong similarity to uncharacterized C. elegans H27D07.4 7TM chemoreceptor, srw family C44C3.5 C44C3.5 Protein of unknown function, has high similarity to uncharacterized C. elegans C44C3.6 7TM chemoreceptor, srw family C44C3.6 C44C3.6 Protein of unknown function, has high similarity to uncharacterized C. elegans K12D9.5, which is predicted to be a G protein-coupled receptor 7TM chemoreceptor, srw family C44C3.7 C44C3.7 Protein of unknown function, has high similarity to uncharacterized C. elegans C03A7.3 7TM chemoreceptor, srw family C44C3.9 C44C3.9 Protein of unknown function, putative paralog of C. elegans H27D07.6 7TM chemoreceptor, srh family C44C8.1 C44C8.1 Protein containing two F-box domains, which serve as a link between a target protein and a ubiquitin-conjugating enzyme, has high similarity to uncharacterized C. elegans C44C8.4 This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins. C44C8.2 C44C8.2 Protein containing two F-box domains, which serve as a link between a target protein and a ubiquitin-conjugating enzyme, has very strong similarity to uncharacterized C. elegans C44C8.3 C44C8.3 C44C8.3 Protein containing two F-box domains, which serve as a link between a target protein and a ubiquitin-conjugating enzyme, has very strong similarity to uncharacterized C. elegans C44C8.2 This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins. C44C8.4 C44C8.4 Protein containing two F-box domains, which serve as a link between a target protein and a ubiquitin-conjugating enzyme, has very strong similarity to uncharacterized C. elegans C44C8.2 This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins. C44C8.6 C44C8.6 Protein with high similarity to MAP kinase-activated protein kinase (human MAPKAPK3), which is phosphorylated by CSBP1, CSBP2, ERK2(MAPK1), and SAPK (MAPK8) MAP kinases, contains two protein kinase domains protein kinase C44E12.1 C44E12.1 Member of the M20, M25, or M40 peptidase family of zinc metalloproteases, has moderate similarity to uncharacterized S. pombe Spcc757.05cp C44E12.3 n2P17;n2P17m2-1;n2P17m3;C44E12.3 Protein of unknown function, has a region of low similarity to a region of potassium channel subfamily K member 9 (TASK-3, human KCNK9), which mediates a K+-selective conductance that is inhibited by acidic extracellular pH and modulated by anesthetics C44E4.1 C44E4.1 Protein containing a DNA polymerase processivity factor domain C44E4.2 C44E4.2 Protein of unknown function C44E4.3 C44E4.3 Protein with high similarity to mitochondrial aspartate aminotransferase (human GOT2), which transfers aspartate amino groups to 2-oxoglutarate forming oxaloacetate and glutamate, contains an aminotransferase class I and II domain aminotransferase C44E4.4 C44E4.4 Protein containing an RNA recognition motif (RRM, RBD, or RNP), has low similarity to Sjogren syndrome antigen B (human SSB), which is an RNA-binding protein that is associated with Sjogren syndrome and systemic lupus erythematosus RNA-binding protein C44E4.5 C44E4.5 Protein with weak similarity to C. elegans T05C3.3 gene product C44E4.6 C44E4.6 Protein with high similarity to acyl-coenzyme-A binding protein (S. cerevisiae Acb1p), which is involved in sphingolipid synthesis, contains an acyl CoA binding domain acyl-CoA-binding protein C44E4.7 C44E4.7 Putative paralog of C. elegans C44E4.1 C44F1.1 C44F1.1 Protein of unknown function C44F1.2 C44F1.2 Protein containing a SAND (Sp100, AIRE-1, NucP41/75 and DEAF-1/suppressin) domain, which may bind DNA, has weak similarity to a region of glucocorticoid modulatory element binding protein 1 (mouse Gmeb1), which may form a complex to regulate transcription SAND domain C44F1.3 lec-4;C44F1.3 Member of the galectin family, which are lectins that bind beta galactosides, has moderate similarity to galectin (C. elegans LEC-1), which is a galactoside-binding lectin galactoside binding lectin; lec-4 encodes a predicted galectin that exhibits sugar binding properties in vitro. C44F1.4 C44F1.4 Protein of unknown function C44F1.5 C44F1.5 Protein containing an adenylate and guanylate cyclase catalytic domain, has weak similarity to adenylate cyclase type 1 (mouse Adcy1), which is a neurospecific, calcium-calmodulin stimulated adenylyl cyclase that converts ATP to cAMP adenylyl cyclase; acy-3 encodes a predicted member of the adenylyl cyclase family with highest similarity to human adenylate cyclase type 5; expressed in the support cells of ciliated neurons, in the head and tail ganglia, in two pairs of neurons in the retrovesicular ganglia, and in the spermatheca. C44H4.1 C44H4.1 Protein containing twelve leucine rich repeats, which mediate protein-protein interactions, has low similarity to a region of C. elegans SYM-1, which is required for attachment of body muscle to cuticle in the absence of MEC-8 Leucine Rich Repeat (2 copies) (6 domains) C44H4.2 sym-5;C44H4.2 Protein containing thirteen leucine rich repeats, which mediate protein-protein interactions, has low similarity to C. elegans SYM-1, which is required for attachment of body muscle to cuticle in absence of MEC-8 Drosophila chaoptin protein like; sym-5 encodes a predicted transmembrane protein that contains 13 contiguous leucine-rich repeats (LRRs) and that is similar to SYM-1, a secreted protein involved in muscle attachment; sym-5 activity appears to be required for embryogenesis and functionally overlaps with that of sym-1 and mec-8 in affecting muscle attachment; in addition, loss of sym-5 activity via RNA-mediated interference (RNAi) in a hypersensitized strain indicates that SYM-5 may also be required for locomotion, body morphology, and normal rates of postembryonic growth. C44H4.3 sym-1;C44H4.3 Protein required for attachment of body muscle to cuticle in absence of MEC-8, member of the leucine rich repeat (LRR) protein family Drosophila chaoptin protein like C44H4.4 C44H4.4 Protein of unknown function C44H4.5 tap-1;C44H4.5 Activator of the MOM-4 protein kinase Protein phosphatase 2C C44H4.6 C44H4.6 Protein containing a protein kinase domain, has moderate similarity to glycogen synthase kinase-3 beta (mouse Gsk3b), which is a serine-threonine protein kinase involved in embryonic development glycogen synthase kinase (CDC2/CDKX subfamily) C44H4.7 C44H4.7 Protein of unknown function, has similarity over a region of the N-terminus to a region of S. cerevisiae mucin Muc1p eor-2 encodes an unfamiliar protein, similar to CG17233 in Drosophila and KIAA1205 in H. sapiens, required for signal transduction by both RAS and Wnt pathways in both excretory system development and P12 fate specification. C44H9.1 C44H9.1 Protein containing a UDP-glucoronosyl and UDP-glucosyl transferase domain, which transfer glycosyl groups to small hydrophobic molecules, has low similarity to UDP glycosyltransferase 2 family polypeptide B7 (human UGT2B7), which glucuronidates lipids UDP-glucuronosyltransferase C44H9.2 C44H9.2 Putative ortholog of C. elegans C44H9.4 gene product NAM7 like protein C44H9.4 C44H9.4 Protein of unknown function, has a region of weak similarity to a region of C. elegans SMG-2, which is involved in nonsense-mediated mRNA decay, mRNA surveillance and RNAi-mediated gene suppression NAM7 like protein C44H9.5 C44H9.5 Protein of unknown function C44H9.6 C44H9.6 Protein with strong similarity to C. elegans C08B6.2 gene product C44H9.7 C44H9.7 Protein of unknown function C44H9.8 C44H9.8 Protein of unknown function C45B11.1 C45B11.1 Protein containing two P21-Rho-binding domains, also known as a Cdc42 Rac interactive binding (CRIB) domains and two protein kinase domains, has moderate similarity to p21(CDKN1A)-activated kinase 4 (human PAK4) serine/threonine kinase (PAK/STE20 subfamily) C45B11.2 C45B11.2 Protein of unknown function, has a region of low similarity to microsomal epoxide hydrolase (human EPHX1), which hydrates reactive epoxides to form dihydrodiols and detoxifies cytochrome p450-generated epoxides from the metabolism of xenobiotics epoxide hydrolase like C45B11.3 C45B11.3 Member of the short-chain dehydrogenase-reductase family, which are NAD- or NADP-dependent oxidoreductases, has high similarity to a region of C. elegans C17G10.8, which is involved in lipid metabolism alcohol dehydrogenase C45B11.4 C45B11.4 Member of the 7-transmembrane chemoreceptor family of G protein-coupled receptors (GPCR), has high similarity to uncharacterized C. elegans T04C12.2 C45B2.1 C45B2.1 Protein of unknown function, has high similarity to uncharacterized C. elegans C45B2.2 C45B2.2 C45B2.2 Protein of unknown function, has high similarity to uncharacterized C. elegans C45B2.1 C45B2.3 C45B2.3 Protein of unknown function, has high similarity to uncharacterized C. elegans C45B2.1 C45B2.4 gbr-5;C45B2.4 Protein containing neurotransmitter-gated ion-channel ligand binding and transmembrane domains, has low similarity to glycine receptor alpha 2 subunit (rat Glra2), which plays an important role in inhibiting neurotransmitter release Glycine receptor; ggr-2 encodes a predicted member of the GABA/ glycine receptor family of ligand-gated chloride channels that affects thermotaxis; expressed in neurons that include SMDV, SMDD, SIAV, CAN, HSN, DD, and is weakly expressed in the egg-laying muscles. C45B2.5 C45B2.5 Protein with high similarity to glutamine synthase (rat Glul), which catalyzes the condensation of glutamate and ammonia to form glutamine and may clear L-glutamate from neuronal synapses, contains one glutamine synthetase domain Glutamine synthetase C45B2.6 C45B2.6 Member of the palatin family, which are storage proteins that may also catalyze the cleavage of fatty acids from membrane lipids, contains three ankyrin (Ank) repeats, has a region of low similarity to a region of group VI phospholipase A2 (human PLA2G6) C45B2.7 ptr-4;C45B2.7 Has similarity to several C. elegans proteins of unknown function that may be related to H. sapiens NPC1 (involved in Niemann-Pick disease) C45B2.8 C45B2.8 Protein of unknown function C45E1.1 nhr-64;C45E1.1 Member of the nuclear hormone receptor/Zinc finger protein family hormone receptor/zinc finger protein; nhr-64 encodes a conserved nuclear receptor that is a member of the NR2 subfamily of nuclear receptors that contains Drosophila and human HNF4 (OMIM:600281, mutations in human HNF4A are associated with Type I MODY (maturity-onset diabetes of the young)); by homology, NHR-64 is predicted to function as a transcription factor that may activate or repress transcription in response to a hormonal signal; however, as loss of nhr-64 activity via RNAi does not result in any obvious abnormalities, the precise role of NHR-64 in C. elegans development and/or behavior is not yet known; nhr-64 is broadly expressed and detected in anterior and posterior neurons, the ventral nerve cord, the pharynx, gut, and hypodermis. C45E1.4 C45E1.4 Putative ortholog of C. elegans C45E1.3 gene product C45E5.1 C45E5.1 Member of the haloacid dehalogenase or epoxide hydrolase family, has low similarity to S. cerevisiae Pho13p, which is a 4-Nitrophenylphosphatase C45E5.2 C45E5.2 Member of the glycosyl hydrolase 18 family, has a region of low similarity to chitinase 3-like 1 (cartilage glycoprotein-39, human CHI3L1), which binds chitin but lacks chitinase activity and is expressed in rheumatoid arthritis cartilage C45E5.3 C45E5.3 Member of the glycosyl hydrolase 18 family, has low similarity to chitinase 3-like 1 (cartilage glycoprotein-39, human CHI3L1), which binds chitin but does not have chitinase activity and is expressed in rheumatoid arthritis cartilage and synovial cells C45E5.4 C45E5.4 Protein of unknown function C45E5.5 H35B03.2;C45E5.5 Protein of unknown function, has a region of low similarity to subunit p30 of ribonuclease P (human RPP30), which processes 5' ends of precursor tRNAs and is associated with systemic sclerosis C45E5.6 nhr-46;C45E5.6 Member of the nuclear hormone receptor, C4-type zinc finger protein family nuclear hormone receptor C45G3.1 C45G3.1 Protein containing two IQ calmodulin-binding domains Actinin-type actin-binding domain containing proteins; The C45G3.1 gene encodes a protein, with one N-terminal calponin-like actin-binding domain and two IQ calmodulin-binding domains, that is likely to be required for spindle structure and function, and (indirectly) for neural function, based on its orthology to Drosophila ABNORMAL SPINDLE and on its joint sterile and uncoordinated RNAi phenotypes; C45G3.1 is also orthologous to human ASPM (OMIM:605481), which when mutated leads to primary microcephaly; C45G3.1 is required for embryonic and larval viability, germline maintenance, vulval morphogenesis, meiosis, and locomotion. C45G3.2 C45G3.2 Protein with weak similarity to H. sapiens Hs.129917 (Homo sapiens mRNA for triple LIM domain protein) C45G3.3 C45G3.3 Member of the biotin or lipoate A-B protein ligase family, which catalyze biotin or lipoic acid attachment to enzymes gip-2 encodes a member of the Biotin/lipoate A/B protein ligase family. C45G3.4 C45G3.4 Protein of unknown function C45G7.1 C45G7.1 Protein with moderate similarity to C. elegans F22A3.6, which is a possible lysozyme C45G7.2 C45G7.2 Protein with strong similarity to C. elegans F22A3.6, which is a possible lysozyme C45G7.4 C45G7.4 Protein containing a C3HC4 type (RING) zinc finger, which may mediate protein-protein interactions zinc finger protein C45G7.6 cdh-10;C45G7.5;C45G7.6 Protein containing three cadherin domains, which are found in the extracellular domain of receptors and cell adhesion proteins, has a region of weak similarity to a region of cadherin 23 (otocadherin, mouse Cdh23), which is involved in vestibular function C45G9.1 C45G9.1 Protein containing a protein kinase domain, has low similarity to a region of S. cerevisiae Hrr25p, which is a casein kinase I (serine/threonine/tyrosine protein kinase) involved in DNA repair and meiosis Protein kinase C45G9.10 C45G9.10 Protein of unknown function C45G9.11 C45G9.11 Protein of unknown function C45G9.12 C45G9.12 Protein of unknown function C45G9.2 C45G9.2 Member of the uncharacterized protein family UPF0034, has high similarity to uncharacterized human PP35 This gene encodes a protein predicted by Eisenberg and coworkers, with 52% accuracy, to be mitochondrial. C45G9.4 C45G9.4 Protein of unknown function, has very strong similarity to uncharacterized C. elegans C45G9.9 C45G9.5 C45G9.5 Protein of unknown function C45G9.6 C45G9.6 Protein of unknown function C45G9.7 C45G9.7 Member of the PDZ domain (also known as DHR Or GLGF) protein family C45G9.8 C45G9.8 Protein of unknown function, has moderate similarity to uncharacterized C. elegans Y75B7B.1 C45G9.9 C45G9.9 Protein of unknown function, has very strong similarity to uncharacterized C. elegans C45G9.4 C45H4.1 C45H4.1 G protein-coupled receptor of an unnamed subfamily, no homolog found in human or D. melanogaster C45H4.10 C45H4.10 Protein containing a DUF40 domain of unknown function, which contain four conserved cysteines, has moderate similarity to uncharacterized C. elegans F40D4.6 C45H4.11 C45H4.11 Protein containing a DUF40 domain of unknown function, which contain four conserved cysteines C45H4.12 C45H4.12 Member of the 7-transmembrane chemoreceptor family of G protein-coupled receptors (GPCR), has high similarity to uncharacterized C. elegans T23F1.4 7TM chemoreceptor, str family C45H4.13 C45H4.13 Protein of unknown function C45H4.14 C45H4.14 Protein of unknown function, has high similarity to uncharacterized C. elegans Y5H2B.3 C45H4.15 C45H4.15 Member of the 7-transmembrane chemoreceptor family of G protein-coupled receptors (GPCR), has low similarity to C. elegans ODR-10, which is a G protein-coupled receptor involved in odorant response 7TM chemoreceptor, str family C45H4.16 C45H4.16 Protein containing a DUF40 domain of unknown function, which contain four conserved cysteines, has high similarity to uncharacterized C. elegans K09C6.5 C45H4.17 C45H4.17 Member of the cytochrome P450 family, has low similarity to cytochrome P450 subfamily 2J polypeptide 4 (rat Cyp2j4), which is a monooxygenase that converts arachidonic acid to hydroxyeicosatetraenoic and epoxyeicosatrienoic acids cytochrome P450 C45H4.2 C45H4.2 Member of the cytochrome P450 family, has low similarity to cytochrome P450 subfamily IIE 1 (human CYP2E), which is a monooxygenase involved in xenobiotic, ethanol, and fatty acid metabolism, apoptosis, and oxidative stress cytochrome P450 C45H4.3 C45H4.3 G protein-coupled receptor, member of unnamed subfamily with distant homology to SRG subfamily, no homolog found in human or D. melanogaster C45H4.5 C45H4.5 Member of the transposase family, which are required for excising and inserting mobile genetic elements, has high similarity to uncharacterized C. elegans Y51H4A.H C45H4.6 C45H4.6 Protein containing a DUF40 domain of unknown function, which contain four conserved cysteines C45H4.7 C45H4.7 Protein containing a DUF40 domain of unknown function, which contain four conserved cysteines, has high similarity to uncharacterized C. elegans C45H4.8 C45H4.8 C45H4.8 Protein containing a DUF40 domain of unknown function, which contain four conserved cysteines, has high similarity to uncharacterized C. elegans C45H4.7 C45H4.9 C45H4.9 Protein containing a DUF40 domain of unknown function, which contain four conserved cysteines, has moderate similarity to uncharacterized C. elegans C45H4.8 C46A5.1 C46A5.1 Member of the protein-tyrosine phosphatase family, which are involved in control of cell growth, proliferation, and differentiation, has a region of low similarity to a region of human PTPN2, which is a non-receptor protein tyrosine phosphatase protein-tyrosine phosphatase C46A5.2 C46A5.2 Member of the amiloride-sensitive sodium channel family, which are involved in sodium reabsorption C46A5.3 col-14;col14;C46A5.3 Collagen cuticular collagen; col-14 encodes a collagen protein that affects vulval morphology in a large-scale RNAi screen; mRNA expressed in embryos and transcript levels peak during each larval stage. C46A5.4 C46A5.4 Member of the animal heme peroxidase family, has a region of moderate similarity to a region of melanoma associated gene (human D2S448), which is a tumor antigen and possible peroxidase that may play a role in apoptosis and immune responses peroxidase C46A5.5 C46A5.5 Protein of unknown function C46A5.6 C46A5.6 Protein of unknown function C46A5.8 C46A5.8 Protein of unknown function C46A5.9 hcf-1;C46A5.9 Protein containing three Kelch motif domains, has moderate similarity to host cell factor 2 (human HCF-2), which is a transcriptional co-activator that is involved in promoting Herpes simplex viral (HSV) transcription factor VP16-induced complex formation C46C11.1 C46C11.1 Protein with low similarity to hormone-sensitive lipase (human LIPE), which is a triacylglycerol lipase involved in fatty acid mobilization, energy homeostasis and steroidogenesis hormone sensitive lipase C46C11.2 C46C11.2 Protein of unknown function, has weak similarity to C. elegans F40F9.5 C46C11.3 C46C11.3 Protein of unknown function C46C2.1 C46C2.1 Protein containing a protein kinase domain, has low similarity to protein kinase with no lysine 1 (rat Prkwnk1), which is a serine/threonine kinase whose catalytic lysine is located in subdomain I, not in subdomain II serine/threonine kinase; wnk-1 is orthologous to the human gene PROTEIN KINASE, LYSINE-DEFICIENT 1 (PRKWNK1; OMIM:605232), which when mutated leads to pseudohypoaldosteronism type II. C46C2.2 C46C2.2 Member of the sugar (and other) transporter family, has low similarity to C. elegans OCT-1, which is an organic cation membrane transporter with broad substrate specificity transport protein C46C2.3 C46C2.3 Protein with moderate similarity to C. elegans T24H10.5 gene product C46C2.4 C46C2.4 Member of the alpha or beta hydrolase fold family, has a region of low similarity to dipeptidyl peptidase II (quiescent cell proline dipeptidase, rat Dpp7), which is a serine protease that may be involved in the response to wounding alpha/beta hydrolase fold C46C2.5 C46C2.5 Protein of unknown function, has weak similarity to C. elegans F53H4.2 C46E1.1 C46E1.1 Protein of unknown function C46E1.2 gcy-36;C46E1.2 Protein containing an adenylate and guanylate cyclase catalytic domain, has moderate similarity to rat Gucy1b2, which is the beta 2 subunit of the enzyme guanylate cyclase that converts GTP to cGMP GUANYLATE CYCLASE SOLUBLE, BETA-2 CHAIN (EC 4.6.1.2) (76 KD CHAIN); gcy-36 encodes a predicted soluble guanylate cyclase that genetically interacts with npr-1 with respect to feeding behavior; expressed in AQR, PQR, and URX3. C46E10.1 C46E10.1 Protein of unknown function, has similarity to C. elegans Y71F9A_291.A C46E10.10 C46E10.10 Protein with similarity to G protein-coupled receptors 7TM chemoreceptor, srh family C46E10.2 C46E10.2 Protein with strong similarity to C. elegans E04F6.14 gene product C46E10.3 C46E10.3 Protein containing a coiled-coil region overlapping a bZIP domain, has weak similarity to a region of human TPR (translocated promoter region, a nuclear pore complex-associated protein involved in activation of oncogenic kinases) C46E10.4 C46E10.4 Protein of unknown function, has low similarity to uncharacterized C. elegans C46E10.5 C46E10.5 C46E10.5 Protein of unknown function, has low similarity to uncharacterized C. elegans C46E10.4 C46E10.6 C46E10.6 Protein of unknown function, has high similarity to uncharacterized C. elegans F40H7.2 7TM chemoreceptor, srx family C46E10.7 C46E10.7 Member of the 7-transmembrane chemoreceptor family of G protein-coupled receptors (GPCR), has strong similarity to uncharacterized C. elegans C46E10.10 7TM chemoreceptor, srh family C46E10.8 C46E10.8 Protein containing two C2H2 type zinc finger domains, which bind nucleic acids zinc finger protein C46E10.9 C46E10.9 Protein containing six C2H2 type zinc finger domains, has a region of low similarity to human ZNF146, which is a zinc finger that may be involved in the development or progression of pancreatic carcinomas zinc finger protein C46F11.1 unc-93;C46F11.1 Putative membrane protein involved in muscle action UNC-93 protein; A novel putative transmembrane protein that affects muscle contraction and egg-laying; it is predicted to be a component of a two-pore potassium channel complex together with SUP-9 and SUP-10; it is expressed in head neurons including the four SIA neurons. C46F11.2 C46F11.2 Protein with high similarity to glutathione reductase (human GSR), which protects against oxidative injury, member of the pyridine nucleotide-disulphide oxidoreductase family, contains one pyridine nucleotide-disulphide oxidoreductase dimerization domain pyridine nucleotide-disulphide oxidoreductases class-I; C46F11.2 is orthologous to human MITOCHONDRIAL GLUTATHIONE REDUCTASE (GSR; OMIM:138300); GSR deficiency has been associated with hemolytic anemia. C46F11.3 C46F11.3 Protein of unknown function C46F11.4 C46F11.4 Member of the DEAD or DEAH box ATP-dependent RNA helicase family and contains a helicase conserved C-terminal domain, has low similarity to S. cerevisiae Prp5p, which is a pre-mRNA processing RNA helicase and snRNA-associated spliceosomal protein ATP-dependent RNA helicase C46F11.5 C46F11.5 Protein of unknown function C46F2.1 C46F2.1 Protein of unknown function C46F4.1 C46F4.1 Member of the rhodopsin family of G protein-coupled receptors (GPCR), has weak similarity to uncharacterized C. elegans F57B7.1 C46F4.2 C46F4.2 Protein with high similarity to long-chain fatty acid-Coenzyme A ligase 4 (human FACL4), which functions in lipid metabolism, anti-apoptosis, possibly in learning, and may be associated with Alport syndrome, member of the AMP-binding enzyme family long-chain-fatty-acid coA ligase C46F9.1 C46F9.1 Protein containing four meprin and TRAF homology (MATH) domains, has high similarity to uncharacterized C. elegans C46F9.3 C46F9.2 C46F9.2 Protein containing three meprin and TRAF homology (MATH) domains, has high similarity to uncharacterized C. elegans C46F9.3 The C46F9.2 gene encodes a protein closely similar to C46F9.3, which has a meprin-associated Traf homology (MATH) domain and may be involved in apoptosis. C46F9.3 C46F9.3 Protein containing three meprin and TRAF homology (MATH) domains, has high similarity to uncharacterized C. elegans C46F9.2 The C46F9.3 gene encodes a protein with a meprin-associated Traf homology (MATH) domain that may be involved in apoptosis. C46F9.4 C46F9.4 Protein containing three meprin and TRAF homology (MATH) domains, has high similarity to uncharacterized C. elegans C46F9.2 C46G7.1 C46G7.1 Protein of unknown function C46G7.2 C46G7.2 Alpha-filagenin, component of core of myosin thick filaments in body wall muscle C46G7.3 C46G7.3 Protein with strong similarity to C. elegans F07B7.6 gene product C46G7.4 C46G7.4 Protein of unknown function The protein product of this gene is predicted to contain a glutamine/asparagine (Q/N)-rich ('prion') domain, by the algorithm of Michelitsch and Weissman (as of the WS77 release of WormBase, i.e., in wormpep77). C46H11.1 C46H11.1 Protein of unknown function C46H11.10 C46H11.10 Protein of unknown function C46H11.11 C46H11.11 Protein containing two formin homology 2 domains, which are found in proteins that control rearrangements of the actin cytoskeleton, has low similarity to formin homology 2 domain containing 1 (human FHOD1), which interacts with human RAC1 GTPase C46H11.2 C46H11.2 Member of the flavin-binding monooxygenase family, which are xenobiotic-metabolising enzymes, has low similarity to flavin containing monooxygenase 3 (mouse Fmo3), which is a dimethylaniline monooxygenase associated with trimethylaminuria upon mutation This gene encodes a protein predicted by Eisenberg and coworkers, with 52% accuracy, to be mitochondrial. C46H11.3 AR16;C46H11.3 Protein of unknown function, has high similarity to uncharacterized C. elegans M01B12.3 C46H11.4 lfe-2;C46H11.5;C46H11.4 Inositol (1,4,5) triphosphate kinase C46H11.6 C46H11.6 Putative paralog of C. elegans F28E10.4 gene product C46H11.7 C46H11.7 Protein containing a DUF18 domain of unknown function, has high similarity to uncharacterized C. elegans C46H11.9 C46H11.8 C46H11.8 Protein containing a DUF18 domain of unknown function C46H11.9 C46H11.9 Protein containing a DUF18 domain of unknown function, has high similarity to uncharacterized C. elegans C46H11.7 C46H3.1 C46H3.1 Protein of unknown function C46H3.2 C46H3.2 Protein containing a Src homology 3 (SH3) domain, which bind proline-rich peptides and two SAM (sterile alpha motif) domains, which may mediate protein-protein interactions tyrosine-protein kinase C46H3.3 C46H3.3 Protein containing ankyrin (Ank) repeats, which may mediate protein-protein interactions, has low similarity to a region of ankyrin (rat Ank3), which is an anchoring protein that links integral membrane proteins to the cytoskeleton ankyrin C47A10.1 C47A10.1 Probable membrane transporter of the ATP-binding cassette (ABC) superfamily, has strong similarity to human multidrug resistance proteins PGY1 and PGY3, has strong similarity to D. melanogaster multidrug resistance proteins MDR49 and MDR65 multidrug resistance protein (p-glycoprotein) (2 domains) C47A10.2 C47A10.2 Member of the 7-transmembrane chemoreceptor family of G protein-coupled receptors (GPCR), has high similarity to uncharacterized C. elegans C47A10.3 C47A10.3 C47A10.3 Member of the 7-transmembrane chemoreceptor family of G protein-coupled receptors (GPCR), has high similarity to uncharacterized C. elegans C47A10.2 C47A10.4 C47A10.4 Member of the C. elegans Sre G protein-coupled chemoreceptor family, which are putative chemosensory receptors 7TM receptor, sre family; C47A10.4 is orthologous to the human gene ALBINISM, OCULAR, TYPE I (OA1; OMIM:300500), which when mutated leads to Nettleship-Falls type ocular albinism. C47A10.5 C47A10.5 Member of the FAD dependent oxidoreductase family, has low similarity to D-amino-acid oxidase (mouse Dao1), which catalyzes the oxidation of neutral and basic D-amino acids into the corresponding keto acids and may affect the activity of NMDA receptors D-amino acid oxidase C47A10.6 C47A10.6 Member of C. elegans Sra integral membrane protein family, which contain 6-7 hydrophobic, putative transmembrane, regions, has low similarity to uncharacterized C. elegans R13D11.6 C47A10.8 C47A10.8 Protein of unknown function, has high similarity to uncharacterized C. elegans F55B12.8 7TM receptor, srx family C47A4.1 C47A4.1 Putative ortholog of C. elegans B0035.2 gene product C47A4.2 C47A4.2 Member of the nucleoside transporter family, which transport nucleosides across the plasma, and possibly nuclear, membrane, has weak similarity to solute carrier family 29 member 1 (rat Slc29a1), which transports nucleosides and nucleoside analog drugs C47A4.3 C47A4.3 Protein with high similarity to rat Ppp1cb, which is the catalytic subunit of a serine-threonine phosphatase that regulates many metabolic processes, member of the serine or threonine protein phosphatase family Ser/Thr protein phosphatase C47A4.5 C47A4.5 Protein of unknown function, has very strong similarity to uncharacterized C. elegans Y45F10B.3 C47B2.1 C47B2.1 Protein of unknown function, has weak similarity to C. elegans F36G9.14 This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins; this gene's encoded protein also contains an FTH/DUF38 motif, which may also mediate protein-protein interaction. C47B2.2 C47B2.2 Protein of unknown function, has a region of moderate similarity to a region of uracil phosphoribosyltransferase (S. cerevisiae Fur1p), which is part of the pyrimidine salvage pathway C47B2.3 tba-2;alpha-2;C47B2.3 Alpha tubulin Tubulin; tba-2 encodes a tubulin with similarity to the murine alpha-2 chain; in small scale assays tba-1(RNAi) has no phenotype and was found to function redundantly with its isotype tba-1 to form spindle structures in embryos with the tbb-1 and tbb-2 beta-isotypes. C47B2.4 pbs-2;C47B2.4 Putative beta-type subunit of 20S proteasome particle Proteasome A-type and B-type C47B2.5 C47B2.5 Protein with high similarity to integrin beta 4 binding protein (translation initiation factor eIF6, human ITGB4BP), which prevents formation of the 80S ribosome, member of the eukaryotic translation initation factor 6 (eIF-6) family EUKARYOTIC TRANSLATION INITIATION FACTOR 6 (EIF-6) C47B2.6 C47B2.6 Protein with high similarity to UDP-galactose-4-epimerase (human GALE), which catalyzes the interconversion of UDP galactose and UDP glucose in the galactose metabolic pathway, member of the NAD-dependent epimerase or dehydratase family NAD dependant epimerase/dehydratase family; The C47B2.6 gene encodes an ortholog of the human gene UDP-GALACTOSE-4-EPIMERASE (GALE; OMIM:606953), which when mutated leads to galactose epimerase deficiency (OMIM:230350). C47B2.7 C47B2.7 Protein containing three elongation factor Tu GTP binding domains and an elongation factor Tu domain 2, which are involved in binding charged tRNA, has low similarity to selenocysteine-tRNA-specific eukaryotic elongation factor (mouse Eefsec) Elongation factor Tu family (contains ATP/GTP binding P-loop); C47B2.7 encodes an ortholog of the mammalian selenocysteine-specific elongation factor SelB (e.g., murine mSelB); mSelB binds GTP, recognizes the Sec-tRNA(Sec) in vitro and in vivo, and is required for efficient selenoprotein translation in vivo, but is unable to bind specifically the eukaryotic SECIS RNA hairpin (apparently requiring at least one other specialized protein). C47B2.8 C47B2.8 Protein of unknown function C47B2.9 C47B2.9 Protein of unknown function C47C12.1 deg-1;C47C12.6;C47C12.1 Member of the amiloride-sensitive sodium channel family, has similarity to human and D. melanogaster amiloride-sensitive cation channels C47C12.2 C47C12.2 Protein of unknown function C47C12.3 C47C12.3 Protein containing four C2H2 type zinc finger domains, has a region of high similarity to a region of zinc finger protein of the cerebellum 1 (mouse Zic1), which functions in cerebellar granule cell proliferation and possibly in cerebellar differentiation zinc finger protein; ref-2 is orthologous to the human gene ZINC FINGER PROTEIN OF CEREBELLUM ZIC2 (ZIC2; OMIM:603073), which when mutated leads to disease. C47C12.4 C47C12.4 Protein containing an EF hand domain, which are found in signaling, buffering or transport proteins, has high similarity to uncharacterized C. elegans K08F11.5 ATP/GTP-binding protein C47C12.5 C47C12.5 Protein of unknown function C47D12.1 C47D12.1;kel-1 Protein containing a FATC (FRAP, ATM, TRRAP C-terminal) domain, a FAT (FRAP, ATM and TRRAP) domain, and a phosphatidylinositol 3- and 4-kinase domain, has weak similarity to transformation transcription domain-associated protein (human TRRAP) Yeast YHP9 like C47D12.2 C47D12.2 Protein of unknown function C47D12.3 C47D12.3 Member of the mitochondrial tricarboxylate carrier (MTC) protein family C47D12.4 C47D12.4 Protein of unknown function, has strong similarity to C. elegans F15A4.2 This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins. C47D12.5 C47D12.5 Protein with strong similarity to C. elegans C17G1.2 gene product C47D12.6 C47D12.6 Protein with high similarity to threonyl-tRNA synthetase (human TARS), which is a class II aminoacyl tRNA synthetase, contains anticodon binding, tRNA synthetase class II core and TGS (ThrRS, GTPase and SpoT) domains threonyl-tRNA synthetase (cytoplasmic); This gene encodes a protein predicted by Eisenberg and coworkers, with 52% accuracy, to be mitochondrial. C47D12.7 kel-1;C47D12.7 Putative KELCH protein, has strong similarity to D. melanogaster KEL and human human KIAA0132 (Kelch-like ECH-associated protein 1), contains an N-terminal BTB/POZ domain and six C-terminal kelch motifs ring canal protein like; kel-1 encodes a BTB/POZ- and Kelch motif-containing protein orthologous to Drosophila Kelch, which is essential for actin organization in ovarian ring canals; in C. elegans, kel-1 is required for regulating feeding during larval development and more specifically, for pharyngeal isthmus peristalsis and efficient trapping of food in the pharynx; KEL-1 is first expressed at the 1.5-fold stage of embryogenesis in the pharyngeal lumen and the nerve ring; later adult and larval expression is confined to the pharyngeal gland cells in which KEL-1 may be required for maintenance of gland cell-specific structures. C47D12.8 C47D12.8 Protein containing an ERCC4 domain, which may modify DNA, has low similarity to excision repair cross complementing 4 (human ERCC4), which is an endonuclease participating in nucleotide excision repair that is associated with xeroderma pigmentosum group F DNA repair protein RAD16 like; C47D12.8 is orthologous to the human gene DNA REPAIR PROTEIN (ERCC4; OMIM:133520), which when mutated leads to disease. C47D2.1 C47D2.1 Protein of unknown function C47D2.2 C47D2.2 Protein containing a cytidine deaminase zinc-binding domain, has moderate similarity to cytidine deaminase (human CDA), which deaminates cytidine and deoxycytidine to uridine and deoxyuridine cytidine deaminase; cdd-1 encodes a cytidine deaminase that contains a zinc-binding region; expressed in the intestine. C47E12.1 C47E12.1 Protein with high similarity to seryl-tRNA synthetase (human SARS), which aminoacylates seryl-tRNA with serine for protein biosynthesis, contains a seryl-tRNA synthetase N-terminal domain and a tRNA synthetase class II core domain (G, H, P, S and T) seryl-tRNA synthetase; srs-2 encodes a predicted cytoplasmic seryl-tRNA synthetase (SerRS), a class II aminoacyl-tRNA synthetase that catalyzes the attachment of serine to its cognate tRNA and is thus required for protein biosynthesis; in C. elegans, SRS-2 activity is required for embryonic and germline development and normal postembryonic growth rates. C47E12.10 C47E12.10 Protein containing a DUF236 domain of unknown function, has high similarity to uncharacterized C. elegans R08A2.1 C47E12.11 C47E12.11 Protein of unknown function, has moderate similarity to uncharacterized C. elegans F02E9.3 C47E12.2 C47E12.2 Protein with high similarity to solute carrier family 25 member 4 (mouse Slc25a4), which is an adenine nucleotide translocator required for metabolism that can induce apoptosis, member of the mitochondrial carrier protein family of membrane transporters ADP/ATP carrier protein C47E12.3 C47E12.3 Member of the glycosyl hydrolase 47 family of alpha-mannosidases, which hydrolyze terminal mannose residues, has moderate similarity to a region of S. cerevisiae Mnl1p, which is involved in endoplasmic reticulum-associated degradation of glycoproteins alpha-mannosidase C47E12.4 C47E12.4 Protein with high similarity to S. cerevisiae Ipp1p, which is a cytoplasmic inorganic pyrophosphatase, member of the inorganic pyrophosphatase family, which catalyze hydrolysis of pyrophosphate formed as product of biosynthetic reactions utilizing ATP inorganic pyrophosphatase C47E12.5 C47E12.5 Protein with high similarity to ubiquitin-activating enzyme E1 (mouse Ube1x), which activates ubiquitin to mark proteins for proteasomal degradation, member of the UBA-THIF-type NAD-FAD binding fold family that also contains a UBACT repeat ubiquitin-activating enzyme; uba-1 encodes a ubiquitin-activating enzyme orthologous to Saccharomyces cerevisiae UBA1 and human UBE1; UBA-1 is essential for embryogenesis and is required for germline development; by homology, UBA-1 is predicted to function in an ATP-dependent reaction that activates ubiquitin prior to its conjugation to proteins that will subsequently be degraded by the 26S proteasome. | uba-1 encodes a ubiquitin-activating enzyme orthologous to Saccharomyces cerevisiae UBA1 and human UBE1; UBA-1 is essential for embryogenesis and is required for germline development; by homology, UBA-1 is predicted to function in an ATP-dependent reaction that activates ubiquitin prior to its conjugation to proteins that will subsequently be degraded by the 26S proteasome; a uba-1 transcriptional reporter fusion is expressed in the larval intestine. C47E12.6 C47E12.6 Protein with strong similarity to C. elegans K09B11.10 gene product C47E12.7 C47E12.7 Protein with similarity to human NNP-1/NOP52, novel nucleolar protein Yeast YD78 like C47E12.8 dhp-2;CeCRMP;UlipA;C47E12.8 Putative dihydropyrimidinase, has strong similarity to C. elegans R06C7.3 and several human dihydropyrimidinases Ulip like protein; The dhp-2 gene encodes an ortholog of the human gene DIHYDROPYRIMIDINASE (DPYS), which when mutated leads to dihydropyrimidinuria (OMIM:222748). C47E12.9 C47E12.9 Protein of unknown function C47E8.1 C47E8.1 Protein of unknown function C47E8.2 C47E8.2 Member of the 7-transmembrane chemoreceptor family of G protein-coupled receptors (GPCR) G-protein coupled receptor, srh family C47E8.3 C47E8.3 Protein of unknown function, has weak similarity to uncharacterized C. elegans E04D5.2 C47E8.4 C47E8.4 Protein of unknown function, has moderate similarity to uncharacterized human DXS9928E C47E8.5 daf-21;HSP90;C47E8.5 Heat shock protein 90, and apparently the only C. elegans ortholog of human Hsp90; involved in dauer larva formation heat shock protein (HSP90); daf-21 encodes a member of the Hsp90 family of molecular chaperones; DAF-21 activity is required for larval development, negative regulation of dauer larva formation, and a number of specific chemosensory behaviors, such as the response to chemicals and odorants detected by the ASE and AWC sensory neurons; a daf-21 sensory defect can be rescued by a cyclic GMP analogue, suggesting that, in regulating chemosensory behaviors, DAF-21 acts at a similar point as the DAF-11 guanylyl cyclase; down-regulation of daf-21 via RNAi results in a small but reproducible reduction in age-1 life span, suggesting that daf-21 is part of a chaperone network required for the extended life span seen in age-1 mutant animals. C47E8.6 C47E8.6 Putative coiled-coil protein, has weak similarity to S. cerevisiae Uso1p C47E8.7 unc-112;C47E8.7 Muscle protein; functions in the attachment of the myofilament lattice to basal cell membranes mitogen inducible MIG-2 protein like; The unc-112 gene encodes a pleckstrin homology domain-containing protein, orthologous to human Mitogen inducible gene-2, that is required for assembly of muscle dense bodies and M lines during embryogenesis; UNC-112 is a dense body/M-line component and requires PAT-3/beta-integrin, UNC-52/perlecan, and PAT-4/integrin-linked kinase for proper localization; UNC-112 binds PAT-4 directly, forms a ternary complex with PAT-4 and PAT-6/actopaxin, and is required for recruitment of PAT-3 and PAT-4 to muscle cell attachment sites; viable unc-112 mutations are suppressed by mutation of dim-1. C47E8.8 C47E8.8 Protein containing a SET domain, which are involved in protein-protein interactions, has a region of weak similarity to a region of cell surface flocculin (S. cerevisiae Muc1p), which is required for invasive and pseudohyphal growth SET domain C47F8.1 C47F8.1 Protein of unknown function, has weak similarity to C. elegans F35E2.8 This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins. C47F8.2 C47F8.2 Protein containing a nuclear hormone receptor C4-type zinc finger domain, has a region of moderate similarity to a region of estrogen related receptor gamma (mouse Esrrg), which binds to DNA at estrogen response elements and activates transcription Zinc finger, C4 type (two domains) C47F8.3 C47F8.3 Member of the galactosyltransferase family, which transfer galactose to GlcNAc termini of growing oligosaccharide chains, has low similarity to UDP-galactose:beta-N-acetylglucosamine beta 1,3-galactosyltransferase (mouse B3galt1) C47F8.4 C47F8.4 Protein with moderate similarity to beta-1,3-glucuronyltransferase 3 (glucuronosyltransferase I, human B3GAT3), which is a type II transmembrane protein that catalyzes the transfer of a glucuronic acid to a specific trisaccharide primer C47F8.5 C47F8.5 Member of the galactosyltransferase family, which transfer galactose to GlcNAc termini of growing oligosaccharide chains, has a region of low similarity to a region of UDP-GlcNAc:betaGal beta-1-3-N-acetylglucosaminyltransferase 5 (human B3GNT5) C47F8.6 C47F8.6 Member of the galactosyltransferase family, which transfer galactose to GlcNAc termini of growing oligosaccharide chains, has a region of low similarity to UDP-galactose:beta-N-acetylglucosamine beta 1,3-galactosyltransferase (mouse B3galt1) C47F8.7 C47F8.7 Protein of unknown function, has weak similarity to C. elegans T02H6.C C47F8.8 nhr-81;C47F8.8 Member of the zinc finger protein family with similarity to nuclear hormone receptors Zinc finger, C4 type (two domains) C47G2.1 cut-1;vmp-1;C47G2.1 Cuticulin component cuticulin; cut-1 encodes a component of cuticlin, an insoluble residue of the nematode cuticle required for alae formation and radial shrinking during dauer differentiation; expressed specifically in the cuticle of dauer larvae and is secreted by the seam cells. C47G2.2 unc-130;C47G2.2 Transcription factor that contains a forkhead (FH) domain fork head domain protein; A member of the forkhead domain family of transcription factors that affects the generation of the AWA and ASG chemosensory neurons and is partially required for male tail morphogenesis and embryogenesis; it is expressed in the AWA and ASG precursors; it is required for the graded spatial expression of the UNC-129 TGF-beta guidance factor. C47G2.3 C47G2.3 Protein of unknown function C47G2.4 C47G2.4 Protein of unknown function, has weak similarity to S. pombe Spcc622.11p C47G2.5 C47G2.5 Protein of unknown function, has a region of moderate similarity to H. sapiens Hs.153121 gene product C48A7.1 egl-19;eat-12;pat-5;C48A7.1 Putative alpha1 subunit of the voltage-dependent calcium channel required for muscle depolarization calcium channel alpha subunit; egl-19 encodes an ortholog of the alpha subunit of mammalian L-type calcium ion channels that affects muscle contraction in late embryonic morphogenesis, movement, egg-laying, mating and feeding; egl-19 is expressed in muscle cells and some neurons. C48A7.2 C48A7.2 Member of the phosphate transporter family, has low similarity to solute carrier family 20 member 1 (human SLC20A1), which is a high-affinity sodium-inorganic phosphate cotransporter that plays a role in phosphate transport and metabolism phosphate permease C48B4.1 C48B4.1 Member of the acyl-CoA oxidase family, which convert acyl-CoA into trans-2-enoyl-CoA, has moderate similarity to peroxisomal acyl-coenzyme A oxidase (human ACOX1), which catalyzes the first step in very long chain fatty acid beta-oxidation Acyl-CoA oxidase I C48B4.10 C48B4.10 Protein of unknown function, has weak similarity to C. elegans C48B4.6 C48B4.11 C48B4.11 Protein of unknown function C48B4.12 C48B4.12 Protein of unknown function, has strong similarity to C. elegans F58A4.1 protein C48B4.2 C48B4.2 Member of the rhomboid family of integral membrane proteins Rhomboid C48B4.3 C48B4.3 Protein of unknown function C48B4.4 C48B4.4 Putative ortholog of C. elegans Y39D8C.1 gene product ATP-binding transport protein; The mutant phenotype of ced-7 is enhanced by mutation of ced-12. C48B4.6 C48B4.6 Protein of unknown function, has weak similarity to C. elegans C48B4.10 C48B4.7 C48B4.7 Protein of unknown function, has weak similarity to C. elegans C48B4.10 C48B4.8 C48B4.8 Protein of unknown function C48B4.9 C48B4.9 Protein of unknown function C48B6.10 C48B6.10 Protein of unknown function C48B6.2 C48B6.2 Protein with strong similarity to S. cerevisiae Imp3p, a component of U3 snoRNP that is required for pre-18S rRNA processing ribosomal protein C48B6.3 C48B6.3 Protein of unknown function C48B6.4 C48B6.4 Protein of unknown function C48B6.5 C48B6.5 Member of the C. elegans Srb family of receptor-like integral membrane proteins, has moderate similarity to uncharacterized C. elegans SRB-7 7TM chemoreceptor, srb family C48B6.6 smg-1;mab-1;C48B6.6 PI-3-related kinase involved in nonsense-mediated mRNA decay, mRNA surveillance kinase C48B6.8 C48B6.8 Protein of unknown function, has weak similarity to uncharacterized PTH-responsive osteosarcoma B1 (human B1) C48B6.9 C48B6.9 Protein of unknown function C48C5.1 C48C5.1 Member of the rhodopsin family of G protein-coupled receptors (GPCR), has low similarity to neuromedin U receptor 2 (human NMU2R), which is a G protein-coupled receptor that modulates intracellular calcium levels family 1 of G-protein coupled receptors C48C5.2 C48C5.2 Protein of unknown function C48C5.3 C48C5.3 Protein of unknown function, has low similarity to uncharacterized C. elegans C25B8.5 C48D1.1 C48D1.1 Protein with weak similarity to C. elegans ZYG-11, which is required for zygote formation C.elegans ZYG-11 like protein C48D1.2 ced-3;C48D1.2 Aspartate-specific cysteine protease; involved in induction of apoptosis; similar to mammalian interleukin-1-beta-converting enzyme Caspase recruitment domain, ICE-like protease (caspase) p20 domain., ICE-like protease (caspase) p10 domain.; The ced-3 gene encodes a protease required for apoptosis. C48D1.3 cho-1;C48D1.3 May be a high-affinity sodium-dependent choline transporter, and has similarity within the central region to human solute carriers SLC5A1, SLC5A5, and SLC5A2 (Hs.1964 , Hs.103983 , Hs.196878 ) choline transporter; cho-1 encodes a high-affinity choline transporter orthologous to members of the sodium-dependent glucose transporter family; CHO-1 is expressed in cholinergic neurons. C48D5.1 nhr-6;cnr8;ceb-1;C48D5.1 Member of the retinoic acid receptor (RAR) subfamily of thyroid hormone receptors, expressed in L3 and L4 larvae and in adults Zinc finger, C4 type (two domains) ; Ligand-binding domain of nuclear hormone receptors; nhr-6 encodes a nuclear receptor of the NR4A4 subfamily that is orthologous to the mammalian NGFI-B receptors and the Drosophila HR38 nuclear receptor (DHR38) that has been implicated in molting and metamorphosis; by homology, NHR-6 likely functions as a transcription factor that, based upon RNAi experiments, is required for normal ovulation and/or spermathecal development or function; an nhr-6 reporter fusion is expressed primarily in the anterior and posterior spermatheca during L3 and L4 larval stages, with some weak and variable expression also observed in two chemosensory neurons; nhr-6 mRNA is expressed in an oscillating manner throughout larval development, in a pattern that is slightly irregular with respect to the timing of larval molts and that exhibits consistently lower expression at the times when these molts actually occur. C48D5.2 ptp-1;nemPTP;C48D5.2 Member of the protein-tyrosine phosphatase family, contains two PDZ, DHR, or GLGF domains and a FERM domain (Band 4.1 family), which link proteins to membranes, has moderate similarity to protein tyrosine phosphatase non-receptor type 4 (human PTPN4) protein tyrosine phosphatase (non receptor type) and band 4.1-like domain; ptp-1 encodes a non-receptor tyrosine phosphatase containing Band 4.1 and PDZ domains that may function in linking cytoplasmic proteins and signaling molecules to sites on the plasma membrane; by homology, PTP-1 is predicted to function in cell signaling, but as loss of PTP-1 function via RNA-mediated interference (RNAi) does not result in any abnormalities, the precise role of PTP-1 in C. elegans development and/or behavior is not yet known. C48E7.1 C48E7.1 Protein of unknown function C48E7.10 C48E7.10 Protein of unknown function C48E7.2 C48E7.2 Protein with weak similarity to RNA polymerase III 62kD (human RPC62), which is a subunit of the RNA polymerase III subcomplex that functions in specific transcription initiation C48E7.3 C48E7.3 Protein containing a bZIP (basic-leucine zipper) transcription factor domain lpd-2 encodes a predicted transcription factor with homology to transcription factors of the CCAAT/Enhancer Binding Protein family (C/EBPA and B, OMIM:116897, 189965, associated with the regulation of mammalian adipocyte differentiation); in C. elegans, LPD-2 activity is required for normal lipid metabolism and wild-type levels of lipogenic enzyme expression, as well as for larval development; in addition, LPD-2 may be part of a conserved pathway regulating lipogenesis, as LPD-2 appears to positively regulate expression of sbp-1, which encodes the C. elegans Sterol Regulatory Element Binding Protein (SREBP) homolog, a basic helix-loop-helix-type transcription factor also required for normal lipid metabolism and larval development. C48E7.4 C48E7.4 Protein containing an olfactomedin-like domain, has low similarity to a region of myocilin (human MYOC), which is a structural protein found in the microtubule cytoskeleton that is associated with juvenile and adult-onset primary open-angle glaucoma C48E7.5 C48E7.5 Protein with weak similarity to C. elegans C34D4.15 gene product C48E7.6 C48E7.6 Protein with weak similarity to membrane-spanning chondroitin sulfate proteoglycan NG2 (rat Cspg4), which functions in cytoskeleton organization, cell proliferation, adhesion, migration, and melanoma metastasis C48E7.7 C48E7.7 Protein of unknown function, has very strong similarity to uncharacterized C. elegans T08B2.12 C48E7.8 C48E7.8 Member of the uncharacterized protein family UPF0063, has weak similarity to uncharacterized C. elegans F52F10.4 C48E7.9 C48E7.9 Protein of unknown function, has a region of low similarity to a region of potassium channel subfamily K member 3 (TASK-1, mouse Kcnk3), which forms an openly rectifying weakly voltage-sensitive channel that acts as a background cardiac K+ conductance C48G7.1 C48G7.1 Protein of unknown function C48G7.2 C48G7.2 Protein containing two Src homology 2 (SH2) domains, which are regulatory modules of intracellular signaling Src homology domain 2 C48G7.3 C48G7.3 Putative paralog of C. elegans Y50E8A.S C49A1.1 C49A1.1 Protein of unknown function, has weak similarity to C. elegans F33E2.5 C49A1.10 C49A1.10 Protein of unknown function C49A1.2 C49A1.2 Member of the C. elegans putative membrane protein family 8, has low similarity to a region of bestrophin (human VMD2), which plays a role in vision and is associated with Bests disease, adult vitelliform macular dystrophy, and bull's eye maculopathy Putative membrane protein C49A1.3 C49A1.3 Member of the C. elegans putative membrane protein family 8, has low similarity to a region of bestrophin (human VMD2), which plays a role in vision and is associated with Bests disease, adult vitelliform macular dystrophy, and bull's eye maculopathy Putative membrane protein C49A1.4 C49A1.4 Protein with strong similarity to human EYA2, Drosophila eyes absent homolog containing a phosphopantetheine attachment site Drosophila clift protein like; eya-1 encodes a protein orthologous to Drosophila EYES ABSENT (EYA), human EYA1, and human EYA4; the human genes EYA1 and EYA4, when mutated, lead to branchiootorenal dysplasia syndrome (BOR; OMIM:113650) and autosomal dominant nonsyndromic sensorineural (late-onset) deafness (DFNA10; OMIM:601316). C49A1.5 C49A1.5 Protein containing a DUF23 domain of unknown function, has strong similarity to uncharacterized C. elegans ZK381.2 C49A1.6 C49A1.6 Protein of unknown function, has moderate similarity to uncharacterized C. elegans K04H8.1 C49A1.8 C49A1.8 Member of the reverse transcriptase protein family, which are RNA-dependent DNA polymerases, has very strong similarity to uncharacterized C. elegans F22B3.3 reverse transcriptase C49A1.9 C49A1.9 Protein with strong similarity to C. elegans Y71A12D.f gene product C49A9.1 C49A9.1 Protein of unknown function, has low similarity to uncharacterized C. elegans C49A9.4 C49A9.2 C49A9.2 Protein of unknown function, has moderate similarity to uncharacterized C. elegans C49A9.3 C49A9.3 C49A9.3 Protein of unknown function, has moderate similarity to uncharacterized C. elegans C49A9.2 C49A9.4 C49A9.4 Protein of unknown function, has low similarity to uncharacterized C. elegans C49A9.1 C49A9.4 is orthologous to the human gene CYSTATIN B (STEFIN B) (CSTB; OMIM:601145), which when mutated leads to disease. C49A9.5 C49A9.5 Protein of unknown function, has high similarity to uncharacterized C. elegans C49A9.9 C49A9.6 C49A9.6 Protein of unknown function, has moderate similarity to uncharacterized C. elegans C49A9.9 C49A9.7 C49A9.7 Member of the rhodopsin family of G protein-coupled receptors (GPCR), has moderate similarity to tachykinin receptor 3 (rat Tacr3), which is a G protein-coupled receptor that may modulate behavior and sensory perception seven trans-smembrane receptor C49A9.8 C49A9.8 Protein containing a UDP-glucoronosyl and UDP-glucosyl transferase domain, which transfer glycosyl groups to small hydrophobic molecules, has weak similarity to UDP-glycosyltransferase 1 A9 (human UGT1A9), which alters xenobiotics to hydrophilic compounds UDP-glucuronosyltransferase C49A9.9 C49A9.9 Putative ortholog of C. elegans E02H9.3 gene product C49C3.1 C49C3.1 Member of the sodium:neurotransmitter symporter family, has low similarity to solute carrier family 6 member 9 (glycine transporter 1, human SLC6A9), which is a sodium and chloride-dependent glycine transporter Sodium:neurotransmitter symporter family (2 domains) C49C3.10 C49C3.10 Protein containing three protein kinase domains, has low similarity to jun N-terminal kinase 2 (human MAPK9), which regulates c-Jun (JUN) in response to proinflammatory cytokines or cellular stress and also triggers apoptosis serine/threonine kinase (2 domains) C49C3.11 C49C3.11 Protein with strong similarity to C. elegans C49C3.12 gene product C49C3.12 C49C3.12 Protein containing a C-type lectin domain, which mediate calcium-dependent carbohydrate recognition, has low similarity to uncharacterized C. elegans ZK39.3 Lectin C-type domain C49C3.13 C49C3.13 Protein containing a C-type lectin domain, which mediate calcium-dependent carbohydrate recognition, has moderate similarity to uncharacterized C. elegans C30H6.4 Lectin C-type domain C49C3.14 C49C3.14 Protein of unknown function, has weak similarity to C. elegans C30H6.3 C49C3.15 C49C3.15 Protein of unknown function C49C3.2 C49C3.2 Protein containing two protein kinase domains, has low similarity to a region of casein kinase 1 epsilon (mouse Csnk1e), which is a putative serine/threonine protein kinase with broad substrate specificity that may function in DNA repair serine/threonine kinase (2 domains) C49C3.3 C49C3.3 Protein of unknown function Ubiquitin family C49C3.4 C49C3.4 Putative ortholog of C. elegans T28F3.8 gene product EGF-like domain C49C3.5 C49C3.5 Protein containing a homeobox domain (homeodomain), which are found in transcription factors Homeobox domain C49C3.6 C49C3.6 Protein of unknown function, has high similarity to uncharacterized C. elegans C49C3.7 C49C3.7 C49C3.7 Protein of unknown function, has high similarity to uncharacterized C. elegans C49C3.6 C49C3.8 C49C3.8 Protein of unknown function C49C3.9 C49C3.9 Protein of unknown function C49C8.1 C49C8.1 Protein containing a protein kinase domain, has high similarity to uncharacterized C. elegans Y71F9AL.2 serine/threonine-protein kinase C49C8.2 C49C8.2 Protein of unknown function C49C8.3 C49C8.3 Protein of unknown function, has weak similarity to C. elegans T07G12.7 C49C8.4 C49C8.4 Member of the cytochrome P450 family, has low similarity to cytochrome P450 subfamily 2C polypeptide 8 (mephenytoin 4-hydroxylase, human CYP2C8), which is a heme-binding monooxygenase that metabolizes steroids, fatty acids, and xenobiotics cytochrome P450 C49C8.5 C49C8.5 Protein containing a beta or gamma fibrinogen C-terminal globular domain, has a region of low similarity to ficolin-2 (hucolin) (human FCN2), which is a predominantly liver calcium-dependent GlcNAc-binding collectin-like lectin C49C8.6 C49C8.6 Protein of unknown function C49D10.1 C49D10.1 Member of the reverse transcriptase family, which are RNA-dependent DNA polymerases, has strong similarity to uncharacterized C. elegans M01A10.4 reverse transcriptase C49D10.10 C49D10.10 Member of the protease protein family protease; C49D10.10 encodes a neprilysin; neprilysins are thermolysin-like zinc metallopeptidases, found on the outer surface of animal cells, that negatively regulate small signalling peptides (e.g., enkephalin, tachykinin, insulin, and natriuretic peptides) by cleaving them; C49D10.10 has no clear orthologs in other organisms. C49D10.11 C49D10.11 Protein with weak similarity to C. elegans W06D11.2 gene product C49D10.2 C49D10.2 Protein containing nuclear hormone receptor C4-type zinc finger and ligand-binding domains, has low similarity to C. elegans NHR-51, which is a putative transcriptional activator involved in developmental processses zinc finger protein C49D10.3 C49D10.3 Member of the 7-transmembrane chemoreceptor family of G protein-coupled receptors (GPCR), has high similarity to uncharacterized C. elegans T19C9.3 7TM chemoreceptor, srh family C49D10.4 C49D10.4 Protein with moderate similarity to C. elegans F41D3.4 gene product C49D10.5 C49D10.5 Protein containing two DUF33 domains of unknown function C49D10.6 nhr-75;C49D10.6 Member of the zinc finger protein family with similarity to nuclear hormone receptors zinc finger protein C49D10.7 C49D10.7 Protein containing three DUF33 domains of unknown function C49D10.8 C49D10.8 Protein containing a DUF33 domain of unknown function, has high similarity to uncharacterized C. elegans F37C4.3 C49D10.9 C49D10.9 Protein containing a nuclear hormone receptor C4-type zinc finger domain, which bind DNA and may be involved in regulation of transcription, has strong similarity to uncharacterized C. elegans C17A2.1 zinc finger protein C49F5.1 C49F5.1 Member of the s-adenosylmethionine synthetase protein family s-adenosylmethionine synthetase C49F5.2 C49F5.2 Protein containing a SET domain, which are involved in protein-protein interactions, has a region of weak similarity to a region of suppressor of variegation 3-9 homolog 2 (mouse Suv39h2), which is a histone methyltransferase modulating chromatin dynamics SET domain C49F5.3 C49F5.3 Protein of unknown function, has moderate similarity to uncharacterized C. elegans F02D10.6 C49F5.4 C49F5.4 Protein containing a nuclear hormone receptor ligand-binding domain, has low similarity to C. elegans NHR-51, which is involved in developmental processes Ligand-binding domain of nuclear hormone receptors, Zinc finger, C4 type (two domains) C49F5.5 C49F5.5 Protein containing a transcriptional adaptor putative zinc finger (TAZ) domain, which may bind transcriptional activators and repressors, has a region of moderate similarity to a region of C. elegans CBP-1, which is a transcriptional activator C49F5.6 C49F5.6 Protein with strong similarity to C. elegans F23D12.2 gene product C49F5.7 C49F5.7 Protein of unknown function, has weak similarity to C. elegans F23D12.1 C49F8.1 C49F8.1 Protein of unknown function C49F8.2 C49F8.2 Protein with moderate similarity to monocarboxylate transporters, has strong similarity to C. elegans T02G5.12, member of the major facilitator superfamily (MFS) monocarboxylate transporter like C49F8.3 C49F8.3 Protein containing a DB module domain C49G7.1 C49G7.1 Protein containing two ankyrin (Ank) repeats, which may mediate protein-protein interactions, and a BRCA1 (breast cancer type 1) C terminus (BRCT) domain, has high similarity to uncharacterized C. elegans K09D9.11 C49G7.10 C49G7.10 Protein of unknown function, has high similarity to uncharacterized C. elegans C49G7.7 C49G7.11 C49G7.11 Member of the ThiJ-PfpI family, has moderate similarity to RNA-binding protein regulatory subunit (human DJ-1), which is a putative oncogene that may regulate the androgen receptor and play a role in RAS protein signal transduction C49G7.2 C49G7.2 Member of the 7-transmembrane chemoreceptor family of G protein-coupled receptors (GPCR), has high similarity to uncharacterized C. elegans Y60A3A.6 7TM chemoreceptor, srh family C49G7.3 C49G7.3 Protein containing a DUF18 domain of unknown function, has very strong similarity to uncharacterized C. elegans C49G7.4 C49G7.4 C49G7.4 Protein containing a DUF18 domain of unknown function, has very strong similarity to uncharacterized C. elegans C49G7.3 C49G7.5 C49G7.5 Protein of unknown function, has high similarity to uncharacterized C. elegans C49G7.10 C49G7.6 C49G7.6 Protein of unknown function C49G7.7 C49G7.7 Protein containing a DUF141 domain of unknown function C49G7.8 C49G7.8 Member of the cytochrome P450 family, has low similarity to cytochrome P450 subfamily 2C polypeptide 8 (mephenytoin 4-hydroxylase, human CYP2C8), which is a heme-binding monooxygenase that metabolizes steroids, fatty acids, and xenobiotics cytochrome P450 C49G7.9 C49G7.9 Putative ortholog of C. elegans F52F10.1 gene product C49G9.1 C49G9.1 Protein of unknown function C49H3.1 gcy-8;C49H3.1 Protein containing an adenylate and guanylate cyclase catalytic domain, two receptor family ligand binding domains and two protein kinase domains, has low similarity to natriuretic peptide receptor B-guanylate cyclase B (human NPR2) receptor-type guanylyl cyclase; gcy-8 encodes a predicted transmembrane guanylyl cyclase that is expressed exclusively in the AFD thermosensory neurons; as loss of gcy-8 activity via RNA-mediated interference does not result in any abnormalities, the precise role of gcy-8 in C. elegans development and/or behavior is not yet known, however, expression in the AFD neurons suggests a possible role in thermotaxis; GCY-8 expression in the AFD neurons appears to be under the control of the paired-like homeodomain protein TTX-1 and the activity of the cyclic nucleotide gated channels TAX-2 and TAX-4. C49H3.10 C49H3.10 Protein with low similarity to exportin T (human XPOT), which is a transport receptor protein that interacts with and exports mature tRNAs from the nucleus in a RanGTP-dependent manner importin beta, nuclear transport factor; imb-6 encodes an importin-beta-like protein orthologous to vertebrate Exportin-t, a specific mediator of tRNA export from the nucleus; IMB-6 is predicted to function by binding tRNAs directly in the presence of the RAN-1 GTPase and facilitating their nucleocytoplasmic transport; in C. elegans, loss of imb-6 function via RNA-mediated interference (RNAi) does not result in any obvious abnormalities. C49H3.11 C49H3.11 Protein with high similarity to ribosomal protein S2 (S. cerevisiae Rps2p), which is a structural ribosomal protein, member of the ribosomal S5 family, which are part of the small ribosomal subunit rps-2 encodes a small ribosomal subunit S2 protein. C49H3.12 C49H3.12 Protein of unknown function C49H3.3 C49H3.3 Protein of unknown function C49H3.4 C49H3.4 Member of the Sm family, which are core constituents of snRNP complexes C49H3.5 C49H3.5 Protein containing an RNA recognition motif (RRM, RBD, or RNP), has a region of moderate similarity to a region of CCR4-NOT transcription complex subunit 4 (human CNOT4), which binds zinc and is likely to function in transcriptional repression zinc-finger transcription regulator; ntl-4 encodes two proteins by alternative splicing, one of which (NTL-4A) has an N-terminal RING finger and a RNA recognition motif ('RRM', 'RBD', or 'RNP'), and both of which have glutamine/asparagine-rich domains. C49H3.6 C49H3.6 Protein with weak similarity to C. elegans myo-3 gene product [A/Band-1/myosin/K12F2.1 Sarcomeric myosin heavy chain, minor component required for thick filaments in body-wall muscle] C49H3.8 C49H3.8 Member of the actin family, which are major cytoskeletal proteins actin-like protein C49H3.9 C49H3.9 Protein of unknown function C50A2.1 C50A2.1 Protein of unknown function C50A2.2 C50A2.2 Protein of unknown function, has weak similarity to C. elegans K06A5.1 C50A2.3 C50A2.3 Protein of unknown function C50A2.4 C50A2.4 Protein containing an ETS domain, which bind promoter DNA, has a region of moderate similarity to a region of mouse Elk1, which is a transcription factor and component of the Ternary Complex Factor (TCF) that binds to the Serum Response Element (SRE) C50B6.1 C50B6.1 Protein of unknown function C50B6.10 C50B6.10 Member of the 7-transmembrane chemoreceptor family of G protein-coupled receptors (GPCR), has low similarity to C. elegans ODR-10, which is involved in odorant response 7TM receptor C50B6.11 C50B6.11 Protein containing neurotransmitter-gated ion-channel ligand binding and transmembrane domains, has low similarity to alpha 3 subunit of the inhibitory glycine receptor (rat Glra3), which may play a role in neuronal differentiation and excitability neurotransmitter-gated ion channel C50B6.12 C50B6.12 Member of the 7-transmembrane chemoreceptor family of G protein-coupled receptors (GPCR), has low similarity to C. elegans ODR-10, which is involved in odorant response C50B6.2 C50B6.2 Protein with weak similarity to nuclear autoantigenic sperm protein (mouse Nasp), which is a histone binding and putative histone storage or transport protein that may play roles in the cell cycle and spermatogenesis histone binding protein C50B6.3 C50B6.3 Protein of unknown function C50B6.4 C50B6.4 Protein containing two collagen triple helix repeats, which are found in some extracellular proteins, and a nematode cuticle collagen N-terminal domain, has moderate similarity to a region of C. elegans BLI-1 collagen C50B6.5 C50B6.5 Protein of unknown function, has moderate similarity to uncharacterized C. elegans C02E7.2 C50B6.6 C50B6.6 Member of the 7-transmembrane chemoreceptor family of G protein-coupled receptors (GPCR), has low similarity to uncharacterized C. elegans R09F10.6 G-protein coupled receptor, srh family C50B6.7 C50B6.7 Protein with high similarity to alpha amylase (human AMY1A), which is a 1,4-alpha-D-glucan glucanohydrolase that degrades starch to glucose monomers, contains one alpha amylase C-terminal all-beta and one alpha amylase N-terminal catalytic domain amylase C50B6.8 C50B6.8 Protein containing three of both nuclear hormone receptor C4-type zinc finger and ligand-binding domains, has a region of weak similarity to pregnane X receptor (human NR1I2), which is a steroid activated nuclear hormone receptor Ligand-binding domain of nuclear hormone receptors, Zinc finger, C4 type (two domains) (2 domains) C50B6.9 C50B6.9 Protein of unknown function C50B8.1 C50B8.1 Protein containing an RNA recognition motif (RRM, RBD, or RNP), has low similarity to uncharacterized human DC50 RNA binding protein C50B8.2 bir-2;C50B8.2 Protein containing two baculoviral inhibitor of apoptosis protein repeat (BIR) domain, which are found in IAP (inhibitor of apoptosis) proteins, has a region of moderate similarity to C. elegans BIR-1, which is required for chromosome movement Inhibitor of Apoptosis domain.; The bir-2 gene encodes a protein with two BIR domains that may be involved in apoptosis. C50B8.3 C50B8.3 Protein of unknown function C50B8.4 C50B8.4 Protein of unknown function C50B8.5 C50B8.5 Protein of unknown function C50C10.1 C50C10.1 Protein containing a DUF215 domain of unknown function, has high similarity to uncharacterized C. elegans F46B6.11 C50C10.2 C50C10.2 Protein containing a DUF215 domain of unknown function, has high similarity to uncharacterized C. elegans C50C10.4 C50C10.3 C50C10.3 Protein containing a DUF215 domain of unknown function, has high similarity to uncharacterized C. elegans C50C10.2 C50C10.4 C50C10.4 Protein containing a DUF215 domain of unknown function, has high similarity to uncharacterized C. elegans C50C10.2 C50C10.5 C50C10.5 Protein containing a DUF215 domain of unknown function C50C10.6 C50C10.6 Member of the 7-transmembrane chemoreceptor family of G protein-coupled receptors (GPCR), has high similarity to uncharacterized C. elegans STR-2 C50C10.7 str-2;C50C10.7 Protein with predicted seven-transmembrane domain that has sequence similarity to diacetyl receptor ODR-10, expressed in either the left or right AWC odorant neurons as a result of a stochastic process C50C3.1 C50C3.1 Protein containing a CCCH-type zinc finger domain, which bind DNA or RNA C50C3.4 C50C3.2;C50C3.3;C50C3.4 Protein containing twelve spectrin repeats, which are involved in cytoskeletal structure, and two EF hand domains, which are found in signaling, buffering or transport proteins, has a region of weak similarity to a region of alpha actinin 2 (human ACTN2) C50C3.5 C50C3.5 Protein containing two EF hand domains, which are found in signaling, buffering or transport proteins Calmodulin C50C3.6 C50C3.6 Putative U5 snRNA-associated splicing factor PRP8, predicted to be involved in association of U5 snRNP with U4/U6 snRNP and to promote both catalytic steps of splicing prp-8 is orthologous to the human gene SIMILAR TO U5 SNRNP-SPECIFIC PROTEIN (220 KD), ORTHOLOG OF S. C50C3.7 C50C3.7 Protein containing an inositol polyphosphate phosphatase catalytic domain, which are (Mg2+)-dependent and (Li+)-sensitive, has weak similarity to human SKIP, which is an inositol polyphosphate 5-phosphatase Inositol polyphosphate-5-phosphatase C50C3.8 C50C3.8 Protein containing a meprin and TRAF homology (MATH) domain and a BTB (BR-C, ttk and babor) or POZ (Pox virus and zinc finger) domain, has weak similarity to C. elegans MEL-26, which is a negative regulator of the meiotic-spindle protein MEI-1 The C50C3.8 gene encodes a protein with a meprin-associated Traf homology (MATH) domain that may be involved in apoptosis. C50C3.9 unc-36;unc-72;C50C3.11;C50C3.9 Protein containing a von Willebrand factor (vWF) type A domain and a cache domain, which exist in animal channel subunits and bacterial chemotaxis receptors, has weak similarity to voltage-dependent calcium channel alpha 2/delta subunit 1 (human CACNA2D1) C50D2.1 C50D2.1 Putative ortholog of C. elegans E04F6.6 gene product C50D2.2 C50D2.2 Member of the amino acid permease family of membrane transporters, has moderate similarity to solute carrier family 7 member 4 (human SLC7A4), which mediates the uptake of cationic amino acids such as arginine amino acid permease C50D2.3 C50D2.3 Protein of unknown function, has weak similarity to C. elegans F40F9.3 C50D2.4 C50D2.4 Protein containing two collagen triple helix repeats, which are found in some extracellular proteins, and a nematode cuticle collagen N-terminal domain, has moderate similarity to a region of collagen type V alpha 2 subunit (human COL5A2) cuticular collagen C50D2.5 C50D2.5 Protein containing an RNA recognition motif (RRM, RBD, or RNP) C50D2.6 C50D2.6 Protein of unknown function, has weak similarity to C. elegans C50F4.8 C50D2.7 C50D2.7 Protein containing an acyl transferase domain This gene encodes a protein predicted by Eisenberg and coworkers, with 68% accuracy, to be mitochondrial. C50D2.8 C50D2.8 Protein with strong similarity to C. elegans Y119D3B.O gene product C50E10.1 C50E10.1 Protein with strong similarity to C. elegans Y57A10A.33 gene product C50E10.10 C50E10.10 Member of the C. elegans Sre G protein-coupled chemoreceptor family, which are putative chemosensory receptors, has moderate similarity to uncharacterized C. elegans F15A4.1 7TM chemoreceptor, sre family C50E10.11 C50E10.11 Member of the C. elegans Sre G protein-coupled chemoreceptor family, which are putative chemosensory receptors, has high similarity to uncharacterized C. elegans C50E10.8 7TM chemoreceptor, sre family C50E10.2 C50E10.2 Putative ortholog of C. elegans C25G4.8 gene product C50E10.3 C50E10.3 Member of the C. elegans Sre G protein-coupled chemoreceptor family, which are putative chemosensory receptors, has high similarity to uncharacterized C. elegans C50E10.7 7TM chemoreceptor, sre family C50E10.4 C50E10.4 Protein of unknown function, has weak similarity to human TGN51 and C. elegans K04C1.2 C50E10.5 C50E10.5 Member of the C. elegans Sre G protein-coupled chemoreceptor family, which are putative chemosensory receptors, has moderate similarity to uncharacterized C. elegans C50E10.8 7TM chemoreceptor, sre family C50E10.6 C50E10.6 Member of the C. elegans Sre G protein-coupled chemoreceptor family, which are putative chemosensory receptors, has high similarity to uncharacterized C. elegans C50E10.8 7TM chemoreceptor, sre family C50E10.7 C50E10.7 Member of the C. elegans Sre G protein-coupled chemoreceptor family, which are putative chemosensory receptors, has high similarity to uncharacterized C. elegans C50E10.8 7TM chemoreceptor, sre family C50E10.8 C50E10.8 Member of the C. elegans Sre G protein-coupled chemoreceptor family, which are putative chemosensory receptors, has high similarity to uncharacterized C. elegans C50E10.7 7TM chemoreceptor, sre family C50E10.9 C50E10.9 Member of the C. elegans Sre G protein-coupled chemoreceptor family, which are putative chemosensory receptors, has weak similarity to uncharacterized C. elegans Y57A10B.5 7TM chemoreceptor, sre family C50E3.1 C50E3.1 Protein of unknown function, has moderate similarity to uncharacterized C. elegans C50E3.3 C50E3.10 C50E3.10 Protein of unknown function, has high similarity to uncharacterized C. elegans T19C9.5 C50E3.11 C50E3.11 Member of the reduced folate carrier family, which transport reduced folate into cells, has low similarity to solute carrier family 19 member 1 (human SLC19A1), which is a reduced folate and thiamine transporter that also transports methotrexate folate transporter C50E3.12 C50E3.12 Protein of unknown function, has weak similarity to C. elegans C50E3.13, S. cerevisiae Ykl054p, and human KIAA0661 C50E3.13 C50E3.13 Protein of unknown function, has similarity to C. elegans C50E3.12 C50E3.2 C50E3.2 Protein with moderate similarity to C. elegans F08D12.4 gene product C50E3.3 C50E3.3 Protein of unknown function, has moderate similarity to uncharacterized C. elegans C50E3.1 C50E3.4 C50E3.4 Protein of unknown function C50E3.5 C50E3.5 Protein of unknown function C50E3.6 C50E3.6 Protein of unknown function C50E3.7 C50E3.7 Protein of unknown function, has high similarity to uncharacterized C. elegans Y75B8A.34 C50E3.8 C50E3.8 Protein with moderate similarity to C. elegans C50E3.7 gene product C50E3.9 C50E3.9 Protein of unknown function, has low similarity to uncharacterized C. elegans C50E3.7 C50F2.1 C50F2.1 Protein of unknown function, has a region of low similarity to a region of C. elegans ZYG-11, which is required for zygote formation C50F2.10 C50F2.10 Protein with strong similarity to C. elegans abf-2 gene product The abf-2 gene encodes an antimicrobial peptide that is homologous to antibacterial factor ASABF from Ascaris suum and closely related to ABF-1. C50F2.2 C50F2.2 Protein of unknown function, has a region of weak similarity to a region of heavy polypeptide of neurofilament (human NEFH), which is a structural protein of the cytoskeleton that likely regulates axonal caliber and synaptic transmission C50F2.3 C50F2.3 Putative pre-mRNA splicing factor, putative ortholog of S. cerevisiae Syf1p C50F2.4 C50F2.4 Protein of unknown function C50F2.5 C50F2.5 Member of the protein-tyrosine phosphatase family, which are involved in control of cell growth, proliferation, differentiation and transformation, has very strong similarity to uncharacterized C. elegans C43E11.5 C50F2.6 dao-8;C50F2.6 Member of the FK506-binding protein protein family peptidyl prolyl cis-trans isomerase; fkb-5 encodes a homolog of human FK506 binding protein 9. C50F2.7 C50F2.7 Protein of unknown function C50F2.8 C50F2.8 Protein containing a Src homology 3 (SH3) domain and a guanylate kinase domain, has a region of weak similarity to a region of C. elegans LIN-2, which is a component of the LIN-2, LIN-7, and LIN-10 cell junction complex involved in vulval development C50F2.9 C50F2.9 Protein with strong similarity to C. elegans abf-1 gene product The abf-1 gene encodes a homolog of the antibacterial factor ASABF from Ascaris suum; it is closely related to abf-2. C50F4.1 C50F4.1 Protein containing a DUF227 domain of unknown function C50F4.10 C50F4.10 Protein containing a protein kinase domain, has moderate similarity to uncharacterized C. elegans R13H9.5, which is a serine/threonine protein kinase serine/threonine kinase C50F4.11 mdf-1;C50F4.11 Coiled-coil protein with weak similarity to a family of D. melanogaster myosin heavy chains (see BLAST, see SMART), interacts with mdf-2 and is involved mitotic genome stability mdf-1 encodes a coiled-coil domain-containing protein that is orthologous to the Saccharomyces cerevisiae mitotic spindle checkpoint protein Mad1p; consistent with a role as a checkpoint protein, MDF-1 is required in C. elegans for mitotic genome stability and hence, long-term survival and fertility; in vitro, MDF-1 interacts with MDF-2, the C. elegans Mad2p ortholog, and with IFY-1, a Securin homolog; the maternal effect lethality produced by an mdf-1 mutation can be suppressed by a mutation in fzy-1, which encodes the C. elegans Cdc20 homolog. C50F4.12 C50F4.12 Protein of unknown function C50F4.13 his-35;C50F4.13 Protein with strong similarity to H2A histone family member X (human H2AFX), which is phosphorylated in response to DNA double-strand breaks in recombination, member of the histone family of nucleosomal core proteins histone H2A; his-35 encodes an H2A histone. C50F4.14 C50F4.14 Protein containing one uncharacterized domain DUF6, has weak similarity to C. elegans SQV-7, which is a multisubstrate nucleotide sugar transporter that affects chondroitin and heparan sulfate biosynthesis and has an important role in vulval invagination GDP-fucose transporter; The C50F4.14 gene encodes a putative GDP-fucose transporter orthologous to the human GDP-FUCOSE TRANSPORTER 1 gene (LAD II; OMIM:605881), which when mutated leads to congenital disorder of glycosylation, type IIc. C50F4.16 C50F4.16 Protein of unknown function The C50F4.16 gene encodes a NUDIX hydrolase. C50F4.2 C50F4.2 Member of the phosphofructokinase protein family 6-phosphofructokinase C50F4.3 C50F4.3 Member of the papain family of cysteine proteases, has low similarity to cathepsin H (rat Ctsh), which is a cysteine (thiol) protease that is involved in a variety of proteolytic processes and is inhibited by stefins A and B thiol protease C50F4.4 C50F4.4 Protein of unknown function C50F4.5 C50F4.5 Member of the histone H2B protein family histone H2B; his-41 encodes an H2B histone. C50F4.6 his-36;C50F4.6 Protein of unknown function his-36 encodes an UNSPECIFIED histone. C50F4.7 his-37;C50F4.7 Protein with very strong similarity to H4 histone family member E (human H4FE), which is a chromatin assembly complex component that may be involved in condensation of DNA into nucleosomes, member of the histone family of nucleosomal core proteins histone H4; his-37 encodes an H4 histone. C50F4.8 C50F4.8 Protein of unknown function, has weak similarity to C. elegans C50D2.6 C50F4.9 C50F4.9 Protein of unknown function C50F7.1 C50F7.1 Member of the rhodopsin family of G protein-coupled receptors (GPCR), has low similarity to tachykinin receptor 1 (substance P receptor, mouse Tacr1), which acts in pain transmission, inflammation, cell proliferation, and anxious and aggressive behavior G-protein coupled receptor C50F7.10 C50F7.10 Member of the glycosyl hydrolases family 1, which may be involved in carbohydrate metabolism, has low similarity to a region of lactase-phlorizin hydrolase (human LCT), which is a lactase and phloridzin hydrolase associated with adult type hypolactasia glycosyl hydrolase C50F7.2 C50F7.2 Protein of unknown function, has low similarity to a region of aggrecan 1 (large aggregating chondroitin sulfate proteoglycan, human AGC1), which is a component of cartilage clx-1 encodes a protein that contains 23 copies of a 15 amino acid repeat, possibly derived from a collagen triplet; there is no transcript evidence for this locus. C50F7.3 C50F7.3 Protein of unknown function, has low similarity to uncharacterized C. elegans H06H21.9 C50F7.4 scb2;C50F7.4 Member of the succinyl-CoA ligase, beta subunit protein family succinyl-CoA synthetase beta chain; This gene encodes a protein predicted by Eisenberg and coworkers, with 68% accuracy, to be mitochondrial. C50F7.5 C50F7.5 Protein of unknown function, has low similarity to a region of heavy polypeptide of neurofilament (mouse Nfh), which is a structural protein of the cytoskeleton that may regulates axonal caliber, synaptic transmission, and intermediate filament assembly C50F7.6 C50F7.6 Protein of unknown function C50F7.9 C50F7.9 Protein of unknown function, has weak similarity to C. elegans R09H10.2 C50H11.1 C50H11.1 Member of the AMP-binding enzyme family, has low similarity to S. cerevisiae Fat2p, which is a peroxisomal AMP-binding protein ATP-dependent AMP-binding protein C50H11.10 C50H11.10 Protein containing a DUF32 domain of unknown function, has high similarity to uncharacterized C. elegans R03H4.4 7TM chemoreceptor, srt family C50H11.11 C50H11.11 Protein containing a DUF32 domain of unknown function, has high similarity to uncharacterized C. elegans F48G7.6 7TM chemoreceptor, srt family C50H11.12 C50H11.12 Member of the 7-transmembrane chemoreceptor family of G protein-coupled receptors (GPCR), has weak similarity to C. elegans ODR-10, which is a G protein-coupled receptor involved in odorant response 7TM chemoreceptor, str family C50H11.13 C50H11.13 Protein of unknown function, has high similarity to uncharacterized C. elegans C54E10.3 C50H11.14 C50H11.14 Protein containing a DUF32 domain of unknown function, has high similarity to uncharacterized C. elegans C29G2.4 7TM chemoreceptor, srt family C50H11.15 C50H11.15 Member of the cytochrome P450 family, has moderate similarity to cytochrome P450 subfamily 2a polypeptide 4 (steroid 15-alpha-hydroxylase, mouse Cyp2a4), which is a liver enzyme that catalyzes the hydroxylation of testosterone and estradiol cytochrome P450 C50H11.17 C50H11.17 Protein of unknown function, has high similarity to uncharacterized C. elegans Y73C8C.4 C50H11.2 C50H11.2 Protein containing a DUF32 domain of unknown function, has high similarity to uncharacterized C. elegans C50H11.4 7TM chemoreceptor, srt family C50H11.3 C50H11.3 Protein containing a DUF32 domain of unknown function, has moderate similarity to uncharacterized C. elegans C50H11.4 7TM chemoreceptor, srt family C50H11.4 C50H11.4 Protein containing a DUF32 domain of unknown function, has high similarity to uncharacterized C. elegans R13D7.10 7TM chemoreceptor, srt family C50H11.5 C50H11.5 Protein containing a DUF32 domain of unknown function, has high similarity to uncharacterized C. elegans C50H11.4 7TM chemoreceptor, srt family C50H11.6 C50H11.6 Protein containing a DUF32 domain of unknown function, has high similarity to uncharacterized C. elegans C50H11.5 C50H11.7 C50H11.7 Member of the 7-transmembrane chemoreceptor family of G protein-coupled receptors (GPCR), has low similarity to uncharacterized C. elegans R03H4.9 7TM chemoreceptor, srh family C50H11.8 C50H11.8 Protein of unknown function, has weak similarity to C. elegans H35N09.1 C50H11.9 str-244;C50H11.9 Member of the 7-transmembrane chemoreceptor family of G protein-coupled receptors (GPCR), has high similarity to uncharacterized C. elegans K02H11.7 7TM chemoreceptor, str family C50H2.1 C50H2.1;CeLGR;LGR Member of the leucine-rich repeat-containing, G protein-coupled receptors, LGR, protein family steroid hormone receptor; C50H2.1 is orthologous to the human gene FORKHEAD BOX O1A (RHABDOMYOSARCOMA) (FSHR; OMIM:136533), which when mutated leads to disease. C50H2.10 C50H2.10 Protein of unknown function C50H2.11 C50H2.11 Protein of unknown function C50H2.2 C50H2.2 Protein of unknown function The egl-47 gene encodes a G protein-coupled receptor required for proper function, but not morphology or structure, of the hermaphrodite-specific motor neurons (HSNs) that control egg laying; EGL-47 is expressed in the HSNs and appears to localize at synapses made in the egg-laying system; EGL-47 may interact with GOA-1, a G protein that blocks egg laying. C50H2.3 mec-9;C50H2.3 Protein with EGF-like repeats that is required for touch sensation mechanosensory protein (mec-9); mec-9 encodes a predicted extracellular protein containing six EGF-like repeats,five Kunitz-type protease inhibitor domains, and a glutamic acid-rich region possibly involved in protein-protein interactions; mec-9 encodes two proteins, only one of which, MEC-9L, appears to be required for normal mechanosensory response to gentle touch and proper functioning of the touch receptor neurons; mec-9 interacts genetically with mec-5, which encodes a unique C. elegans collagen secreted by the hypodermis; MEC-9L is expressed and secreted by the touch receptor neurons. C50H2.4 C50H2.4 Protein of unknown function, has moderate similarity to uncharacterized C. elegans C50H2.5 C50H2.5 C50H2.5 Protein of unknown function, has moderate similarity to uncharacterized C. elegans C50H2.4 C50H2.6 C50H2.6 Protein of unknown function C50H2.7 C50H2.7 Protein of unknown function, has low similarity to uncharacterized C. elegans C26E6.1 C51E3.1 C51E3.1 Protein of unknown function, has high similarity to uncharacterized C. elegans C51E3.2, which is a G protein-coupled receptor olfactory receptor C51E3.2 C51E3.2 Member of the rhodopsin family of G protein-coupled receptors (GPCR), has high similarity to uncharacterized C. elegans C51E3.3 opoid receptor C51E3.3 C51E3.3 Protein of unknown function, has high similarity to uncharacterized C. elegans C51E3.2, which is a putative G protein-coupled receptor (GPCR) somatostatin receptor C51E3.4 C51E3.4 Member of the rhodopsin family of G protein-coupled receptors (GPCR), has high similarity to uncharacterized C. elegans C51E3.3 7TM receptor C51E3.5 C51E3.5 Protein with moderate similarity to C. elegans C51E3.4 gene product olfactory receptor C51E3.6 C51E3.6 Member of the nucleobase transporter protein family Mouse YSPL-1 protein like C51E3.7 egl-3;Cepc2;kpc-2;C51E3.7 Proprotein convertase; processes prohormones and proneuropeptides by endoproteolytic cleavage; similar to Kex2-like serine endoproteases prohormone convertase 2; The egl-3 gene encodes a homolog of a mammalian proprotein convertase that participates in peptide secretion. C51E3.8 C51E3.8 Putative ortholog of C. elegans C08B6.4 gene product chitinase C51F7.1 C51F7.1 Protein of unknown function, has a region of weak similarity to a region of protein tyrosine phosphatase non-receptor type 13 (mouse Ptpn13), which may have a role in differentiation processes and in cytoskeletal regulation of the developing nervous sytem C51F7.2 C51F7.2 Protein of unknown function, has high similarity to uncharacterized C. elegans F31E9.2 C51G7.J Y56A3A.33;C51G7.J Member of the exonuclease family, has a region of low similarity to a region of ribonuclease H (70 kDa) (S. cerevisiae Rnh70p), which is an endonuclease that degrades RNA in RNA-DNA hybrids C52A10.1 C52A10.1 Member of the carboxylesterase protein family carboxylesterase C52A10.2 C52A10.2 Member of the carboxylesterase protein family carboxylesterase C52A10.3 C52A10.3 Protein containing an F-box domain, which serve as a link between a target protein and a ubiquitin-conjugating enzyme, has low similarity to uncharacterized C. elegans Y39A1A.16 C52A11.2 C52A11.2 Protein of unknown function Globin C52A11.3 C52A11.3 Member of the PDZ domain (also known as DHR Or GLGF) protein family PDZ domain (Also known as DHR or GLGF). C52A11.4 C52A11.4 Protein with strong similarity to Drosophila Discs lost and human multiple PDZ domain protein (MPDZ); contains 8 lethal[1] discs large-1 tumor suppressor protein-like repeats lethal(1) discs large-1 tumor suppressor protein-like repeats C52B11.2 C52B11.2 Protein containing a K+ channel tetramerization domain, which facilitate assembly of alpha-subunits into functional tetrameric channels, has high similarity to uncharacterized human FLJ20040 potassium channel protein C52B11.3 C52B11.3 Member of the rhodopsin family of G protein-coupled receptors (GPCR), has low similarity to adrenergic receptor alpha 2b (mouse Adra2b), which binds epinephrine and norepinephrine and signals through adenylyl cyclase G-protein coupled receptor C52B11.4 C52B11.4 Protein with weak similarity to C. elegans Y40H7A.7 gene product C52B11.5 C52B11.5 Protein of unknown function, has a region of low similarity to Ras-related GTP-binding protein 5 (rat Rab5a), which regulates endocytic transport RAS-related proteins (weak) C52B9.1 C52B9.1 Member of the choline or ethanolamine kinase family, which catalyze the formation of phosphatidylcholine by the CDP-choline pathway, has moderate similarity to choline-ethanolamine kinase (rat Chkl), which is involved in phosphatidylcholine biosynthesis choline kinase C52B9.10 C52B9.10 Protein of unknown function C52B9.2 C52B9.2 Protein containing three ETS domains, which bind promoter DNA C52B9.3 C52B9.3 Protein with weak similarity to C. elegans K07H8.1 gene product C52B9.4 C52B9.4 Protein of unknown function C52B9.5 C52B9.5 Putative ortholog of C. elegans F48D6.2 gene product 7TM chemoreceptor, srv family C52B9.6 C52B9.6 Member of the ion transport family, which include calcium, sodium, and potassium channels, has a region of low similarity to a region of potassium channel subfamily K member 3 (TASK-1, human KCNK3) C52B9.7 paf-2;C52B9.7 Putative acetylhydrolase, has similarity to human platelet-activating factor acetylhydrolases PAFAH and PAFAH2 paf-2 encodes a homolog of vertebrate Type II Platelet-activating factor-acetylhydrolase (PAF-AH) that is 70% identical to PAF-2 that is required for embryogenesis and affects organization of the hypodermis. C52B9.8 C52B9.8 Protein with high similarity to C. elegans PSA-4, which is a putative component of a SWI/SNF chromatin remodeling complex and is active in the control of mitosis, contains a helicase conserved C-terminal domain and an SNF2 related N-terminal domain helicase C52B9.9 mec-18;C52B9.9 Member of the AMP-binding enzyme family, has weak similarity to S. cerevisiae Acs1p, which is acetyl-CoA synthetase (acetate-CoA ligase) AMP-binding protein; mec-18 encodes a protein similar to firefly luciferase and plant protein 4-coumarate coA ligase; mec-18 is involved in sensory mechanotransduction; genetic interactions with other mec genes suggest that mec-18 maybe involved in negative regulation of the degenerin channel in the touch receptor neurons; mec-18 is expressed exclusively in the touch cells. C52D10.1 C52D10.1 Protein with strong similarity to C. elegans ZK1055.7 gene product C52D10.11 C52D10.11 Putative FMRF-amide neurotransmitter, has similarity to C. elegans FLP-8 C52D10.12 C52D10.12 Protein containing a DUF21 domain of unknown function, has a region of low similarity to a region of S. cerevisiae Ami3p, which is required for normal mitochondrial structure C52D10.12 encodes a homolog of human ACDP1-ACDP4 and a paralog of C01H6.6, C33D12.2, M02F4.3, R04E5.2, and R13G10.4; both C52D10.12 and ACDP1-ACDP4 belong to a family of proteins (defined by NCBI as KOG2118) that are predicted to be membrane-spanning and that share a motif (the 'ACD domain') with proteins from bacteria, yeast, plants, and metazoa; murine Acdp1 is a plasma membrane protein bacterial proteins containing the ACD domain include CorC from Salmonella typhimurium, which is involved in magnesium and cobalt efflux; C52D10.12 has no obvious function in RNAi assays. C52D10.13 C52D10.13 Protein containing two collagen triple helix repeats, which are found in some extracellular proteins, and a nematode cuticle collagen N-terminal domain, has a region of moderate similarity to a region of collagen type V alpha 3 subunit (human COL5A3) cuticular collagen C52D10.2 C52D10.2 Protein with moderate similarity to C. elegans ZK1055.6 gene product C52D10.3 C52D10.3 Protein of unknown function C52D10.5 C52D10.5 Member of the transposase protein family C52D10.6 skr-12;C52D10.6 Member of the Skp1 family, which are required for targeted protein degradation during the cell cycle, has a region of moderate similarity to a region of S. cerevisiae Skp1p, which is a component of Cbf3 kinetochore and SCF (Skp1p-cullin-F-box) complexes cyclin A-associated protein; skr-12 encodes a homolog of Skp1 in S. cerevisiae, a core component of the SCF (Skp1p, Cullin, F-box) ubiquitin-ligase complex that facilitates ubiquitin-mediated protein degradation; SKR-12 has no known function in vivo, since skr-12(RNAi) animals are at least superficially normal. C52D10.7 skr-9;C52D10.7 Member of the Skp1 family, which are required for targeted protein degradation during the cell cycle, has a region of moderate similarity to a region of S. cerevisiae Skp1p, which is a component of Cbf3 kinetochore and SCF (Skp1p-cullin-F-box) complexes cyclin A-associated protein; skr-9 encodes a homolog of Skp1 in S. cerevisiae, a component of the SCF (Skp1, Cullin, F-box) ubiquitin-ligase complex that regulates ubiquitin-mediated protein degradation; SKR-9 is required for posterior body morphogenesis, embryonic and larval development, and postembryonic cell proliferation. C52D10.8 skr-13;C52D10.8 Member of the Skp1 family, which are required for targeted protein degradation during the cell cycle, has a region of moderate similarity to a region of S. cerevisiae Skp1p, which is a component of Cbf3 kinetochore and SCF (Skp1p-cullin-F-box) complexes cyclin A-associated protein; The skr-13 gene encodes a homolog of Skp1 in S. cerevisiae that has no known function in vivo, since skr-13(RNAi) animals are at least superficially normal. C52D10.9 skr-8;C52D10.9 Member of the Skp1 family, which are required for targeted protein degradation during the cell cycle, has a region of moderate similarity to a region of S. cerevisiae Skp1p, which is a component of Cbf3 kinetochore and SCF (Skp1p-cullin-F-box) complexes cyclin A-associated protein; skr-8 encodes a homolog of Skp1 in S. cerevisiae, a component of the SCF (Skp1, Cullin, F-box) ubiquitin-ligase complex that regulates ubiquitin-mediated protein degradation; SKR-8 is required for is required for posterior body morphogenesis, embryonic and larval development, and cell proliferation; SKR-8 can interact with CUL-1, a C. elegans cullin homolog. C52E12.1 C52E12.1 Protein containing nine C2H2 type zinc finger domains, which bind nucleic acids, has a region of low similarity to a region of KRAB zinc finger protein (mouse Mzf22), which functions as a transcriptional repressor via interactions with mouse Trim28 zinc-finger containing protein C52E12.2 unc-104;klp-1;C52E12.2 Plus-end directed motor kinesin required for axonal transport of synaptic vesicles to synaptic regions kinesin-like protein; The unc-104 gene encodes a kinesin-like motor protein homologous to human axonal transporter of synaptic vesicles (ATSV, OMIM: 601255), and is required for anterograde axonal transport of synaptic vesicles as well as differentiation of pre- and postsynaptic domains at inhibitory neuromuscular junctions; UNC-104 is expressed solely in neurons. C52E12.3 sqv-7;C52E12.3 Multisubstrate nucleotide sugar transporter, with effects on chondroitin and heparan sulfate biosynthesis; has important roles in vulval invagination The sqv-7 gene encodes a nucleotide-sugar transporter of the Golgi membrane, that is required for cytokinesis of one-cell embryos and for vulval morphogenesis; SQV-7 promotes glycosaminoglycan biosynthesis by translocating UDP-glucuronic acid, UDP-N-acetylgalactosamine, and UDP-galactose into the lumen of the Golgi apparatus; SQV-7 is biochemically active when transgenically expressed in yeast or mammalian Golgi membranes; the common requirement for SQV-7 in both cytokinesis and morphogenesis may be to promote filling an extracellular space with hygroscopic proteoglycans (either in the eggshell, or underneath the L4 cuticle), which in turn may cause the space to fill with fluid. C52E12.4 C52E12.4 Protein containing two RUN domains, two DENN (AEX-3) domains, and two PLAT (Polycystin-1, Lipoxygenase, Alpha-Toxin) or LH2 (Lipoxygenase homology) domains, has low similarity to rab6 interacting protein 1 (mouse Rab6ip1) C52E2.1 C52E2.1 Putative ortholog of C. elegans C52E2.I gene product This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins; this gene's encoded protein also contains an FTH/DUF38 motif, which may also mediate protein-protein interaction. C52E2.2 C52E2.2 Protein with moderate similarity to C. elegans C52E2.H gene product C52E2.3 C52E2.3 Putative ortholog of C. elegans ZK250.2 gene product C52E2.4 C52E2.4 Putative ortholog of C. elegans C52E2.E gene product C52E2.5 C52E2.5 Putative ortholog of C. elegans ZK250.5 gene product C52E2.6 C52E2.6 Putative ortholog of C. elegans C52E2.B gene product C52E2.7 C52E2.7 Putative ortholog of C. elegans C52E2.B gene product C52E2.8 C52E2.8 Putative ortholog of C. elegans C52E2.A gene product C52E4.1 gcp-1;cpr-1;C52E4.1 Cysteine protease expressed in the intestine cathepsin-like cysteine protease; cpr-1 encodes a cysteine protease of the cathepsin B-like cysteine protease family; cpr-1 appears to be required for embryogenesis; cpr-1 is specifically expressed in the gut of all stages except the embryo and around developing embryos in the gonad; expression of cpr-1 is regulated by three promoter GATA motifs. C52E4.2 mif-2;C52E4.2 Member of the macrophage migration inhibitory factor family, has moderate similarity to D-dopachrome tautomerase (human DDT), which is a melanoma tumor antigen and zinc metalloenzyme that catalyzes conversion of D-dopachrome to 5,6-dihydroxyindole macrophage migration inhibitory factor like protein C52E4.3 C52E4.3 Protein with strong similarity to small nuclear ribonucleoprotein D2 polypeptide (human SNRPD2), which is involved in snRNP biogenesis and pre-mRNA splicing, member of the Sm family, which are core constituents of snRNP complexes small nuclear ribonucleoprotein D2 like C52E4.4 rpt-1;C52E4.4 Putative ATPase subunit of 19S proteasome particle 26S protease regulatory subunit 7; rpt-1 encodes a predicted ATPase subunit of the 19S regulatory complex of the proteasome that affects fertility and embryonic viability. C52E4.5 C52E4.5 Protein with high similarity to mannosidase 1 alpha (mouse Man1a), which trims mannose residues and plays a role in misfolded protein degradation, member of the glycosyl hydrolase 47 family of alpha-mannosidases, which hydrolyze terminal mannose residues alpha 1,2, mannosidase C52E4.6 C52E4.6 Protein containing two cyclin N-terminal domains, has a region of low similarity to S. pombe Pch1p, which is protein kinase likely to be involved in cell cycle progression C52E4.7 C52E4.7 Protein with moderate similarity to C. elegans F53B6.7 gene product C52G5.1 C52G5.1 Protein of unknown function C52G5.2 C52G5.2 Protein of unknown function, has low similarity to uncharacterized human LOC51078 C53A3.1 C53A3.1 Protein containing an F-box domain, which serve as a link between a target protein and a ubiquitin-conjugating enzyme, has low similarity to uncharacterized C. elegans Y39A1A.16 This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins. C53A3.2 C53A3.2 Member of the haloacid dehalogenase or epoxide hydrolase family, has low similarity to S. pombe Pho2p, which is a specific p-nitrophenylphosphatase C53A5.1 C53A5.1 Protein of unknown function C53A5.10 C53A5.10 Protein containing a DUF32 domain of unknown function, has high similarity to uncharacterized C. elegans F54E2.6 C53A5.11 C53A5.11 Protein containing four Kelch motif domains, has a region of low similarity to a region of intracisternal A particle-promoted protein (human IPP), which is an actin-binding protein that plays a role in cell shape and cell size ring canal protein like C53A5.12 gar-3;C53A5.12 Muscarinic acetylcholine receptor, member of the G protein-coupled receptor protein family C53A5.13 C53A5.13 Protein containing a fibronectin type III domain, which are involved in cell surface binding, has low similarity to a region of C. elegans LET-805, which is a putative cell adhesion protein required for movement and elongation during embryogenesis C53A5.2 C53A5.2 Member of the Met-10+-like protein family, which may be involved in methionine biosynthesis, transport or utilization Neurospora met-10 protein like C53A5.3 hda-1;C53A5.3 Histone deacetylase Yeast RPD3 protein like; The hda-1 gene encodes a histone deacetylase 1, similar to histone deacetylases RPD3 from yeast and fly; maternal and zygotic expression of hda-1 is required for embryonic viability, and zygotic expression of hda-1 is also required for gonadogenesis and vulval development. C53A5.4 C53A5.4 Protein containing a protein kinase domain, has low similarity to casein kinase 1 gamma 1 (rat Csnk1g1), which is a serine/threonine protein kinase that may play roles in cell growth and in morphogenesis serine/threonine kinase C53A5.5 C53A5.5 Protein containing a calmodulin binding domain, which form an elongated dimer with calmodulin bound at each end, has low similarity to small conductance calcium-activated potassium channel 1 (rat Kcnn1), which may regulate neuronal membrane excitability calcium-activated potassium channel C53A5.6 C53A5.6 Protein containing a C3HC4 type (RING) zinc finger domain and five Kelch motif domains, has a region of low similarity to a region of intracisternal A particle-promoted protein (human IPP), which plays a role in determining cell size and shape Zinc finger, C3HC4 type (RING finger) C53A5.8 C53A5.8 Protein of unknown function, has low similarity to uncharacterized C. elegans R05D8.6 G-protein coupled receptor, srg family C53A5.9 C53A5.9 Protein containing five Kelch motif domains and a cyclin C-terminal domain, which often form complexes with protein kinases and cyclin dependent protein kinases, has low similarity to intracisternal A particle-promoted protein (human IPP) ring canal protein like C53B4.1 C53B4.1 Member of the sugar (and other) transporter family, has weak similarity to human SLC22A1, which is an organic cation transporter that mediates the elimination of diverse endogenous amines and xenobiotics transport protein C53B4.2 C53B4.2 Protein of unknown function, has low similarity to uncharacterized C. elegans C45G9.8 C53B4.3 C53B4.3 Member of the sugar (and other) transporter family, has low similarity to uncharacterized solute carrier family 22 member 1-like (mouse Slc22a1l), which is a putative transporter that is highly expressed in intestine, kidney, liver and placenta C53B4.3 is orthologous to the human gene UNKNOWN (PROTEIN FOR MGC:23098) (SLC22A1L; OMIM:602631), which when mutated leads to disease. C53B4.4 C53B4.4 Protein containing three phorbol esters or diacylglycerol binding domains (C1 domain), which bind two zinc ions, and three PDZ, DHR, or GLGF domains, which are found in signaling proteins PDZ domain (Also known as DHR or GLGF). ; Phorbol esters/diacylglycerol binding domain (C1 domain) C53B4.5 C53B4.5 Protein with high similarity to C. elegans SQT-3, contains two collagen triple helix repeats, which are found in some extracellular proteins, and a nematode cuticle collagen N-terminal domain collagen C53B4.6 C53B4.6 Member of the YEA4-like protein family, has similarity to the Golgi membrane UDP-GlcNAc transporter of K. lactis Yeast YEA4 like protein C53B4.7 C53B4.7 Protein with high similarity to GDP-mannose-4,6-dehydratase (human GMDS), which is an epimerase that converts GDP-mannose to GDP-mannose-4-keto-6-D-deoxymannose and plays a role in the synthesis of fucosylated oligosaccharides C53B7.1 C53B7.1 Putative member of Immunoglobulin superfamily C53B7.2 C53B7.2 Protein containing a trypsin inhibitor-like cysteine rich domain C53B7.3 C53B7.3 Protein with moderate similarity to C. elegans D1044.7 gene product C53B7.4 C53B7.4 Protein of unknown function, has high similarity to uncharacterized C. elegans K07A12.3 ATP synthase; asg-1 encodes a homolog of ATP synthase G required both for growth at a normally high rate and for normal osmoregulation. C53B7.5 odr-10;C53B7.5 G protein-coupled receptor involved in odorant response, member of large family of putative odorant response proteins, no homolog found in human or D. melanogaster chemoreceptor; The odr-10 gene encodes a member of the 7-transmembrane family of odorant receptors which affects chemotaxis to the volatile odorant diacetyl; it is expressed in two AWA neurons and, at low levels, in the CEP neurons. C53B7.6 C53B7.6 Protein of unknown function, has strong similarity to uncharacterized C. elegans T11F9.14 C53B7.7 C53B7.7 Protein of unknown function, has similarity to C. elegans F40B5.1 C53B7.7 encodes a neprilysin; neprilysins are thermolysin-like zinc metallopeptidases, found on the outer surface of animal cells, that negatively regulate small signalling peptides (e.g., enkephalin, tachykinin, insulin, and natriuretic peptides) by cleaving them; C53B7.7 has no clear orthologs in other organisms. C53C11.1 C53C11.1 Protein of unknown function C53C11.2 C53C11.2 Protein of unknown function C53C11.3 ptr-5;C53C11.3 Putative paralog of C. elegans C41D7.2, has strong similarity to a number of C. elegans proteins and may be related to H. sapiens NPC1, which is involved in Niemann-Pick disease, type C1 C53C11.4 C53C11.4 Protein of unknown function, has high similarity to uncharacterized C. elegans Y54B9A.1 S. muris microneme antigen C53C7.1 C53C7.1 Member of the rhodopsin family of G protein-coupled receptors (GPCR), has low similarity to G protein-coupled receptor 10 (human GPR10), which binds a peptide which stimulates prolactin (human PRL) secretion 7 transmembrane receptor (rhodopsin family) C53C7.2 C53C7.2 Protein of unknown function C53C7.3 C53C7.3 Protein of unknown function C53C9.1 nShab1;C53C9.1 Member of the voltage-gated potassium channel protein family potassium channel protein C53C9.2 C53C9.2 Protein containing six calponin family repeats, which consist of a well conserved 26 amino acid domain, has a region of moderate similarity to a region of C. elegans UNC-87, which is an actin-bundling protein associated with muscle thin filaments C53C9.3 C53C9.3 Protein with high similarity to C. elegans EXP-2, which is an inward rectifying pharyngeal K-type (voltage activated) potassium channel, member of the ion transport family, contains a K+ channel tetramerization domain C53D5.1 C53D5.1 Protein of unknown function, putative paralog of C. elegans C53D5_1638.H C53D5.2 C53D5.2 Protein of unknown function, has strong similarity to C. elegans C53D5_1638.G C53D5.3 C53D5_1638.F;C53D5.F;C53D5.3 Protein of unknown function C53D5.4 C53D5.4 Putative paralog of C. elegans C53D5_1638.D zinc finger protein C53D5.5 C53D5.5 Putative paralog of C. elegans H14N18.4 (Member of the gamma-glutamyltransferase (tentative) protein family) gamma-glutamyltranspeptidase; The C53D5.5 gene encodes an ortholog of the human gene GAMMA-GLUTAMYLTRANSFERASE 1 (GGT1), which when mutated leads to glutathionuria (OMIM:231950). C53D5.6 C53D5_1638.A;C53D5.A;C53D5.6 Protein with moderate similarity to karyopherin beta 3 (human KPNB3), which is a subunit of the nuclear localization signal receptor complex and plays a role in nuclear import of ribosomal proteins importin beta, nuclear transport factor; imb-3 encodes an importin-beta-like protein orthologous to Drosophila, vertebrate, and yeast importin/karyopherin-beta3; IMB-3 is predicted to function as a nuclear transport factor that, with the RAN-1 GTPase, regulates nuclear import of ribosomal proteins; in C. elegans, IMB-3 is essential for embryogenesis and germline development, and may also be required for normal postembryonic growth rates. C53D6.1 C53B4.8;C53D6.1 Protein of unknown function, has low similarity to uncharacterized C. elegans F19H8.4 C53D6.2 unc-129;C53D6.2 Member of the transforming growth factor-beta (TGF-beta) superfamily of secreted signaling molecules; involved in axon guidance bone morphogenetic protein like; The unc-129 gene encodes a member of the TGF-beta family of secreted growth factor signaling molecules; UNC-129 is required for proper axonal guidance of commissural motorneurons and for proper migration of the distal tip cells of the somatic gonad; UNC-129 is expressed in dorsal body wall muscle and at present does not appear to act through the known TGF-beta type I and II receptors. C53D6.3 C53D6.3 Protein containing neurotransmitter-gated ion-channel ligand binding and transmembrane domains, has moderate similarity to C. elegans MOD-1, which is a serotonin-gated chloride channel ligand-gated ion channel C53D6.4 C53D6.4 Member of the rhodopsin family of G protein-coupled receptors (GPCR) angiotensin receptor like C53D6.5 C53D6.5 Protein of unknown function C53D6.6 C53D6.6 Protein of unknown function, has weak similarity to uncharacterized C. elegans K09A11.1 C53D6.7 C53D6.7 Member of the galectin family, has a region of low similarity to galectin (C. elegans LEC-1), which is a galactoside-binding lectin galactoside-binding lectin like C53H9.2 C53H9.2 Member of an uncharacterized GTPase family, has moderate similarity to S. cerevisiae Lsg1p, which is a protein required for normal growth, morphology,mating, and sporulation C53H9.2 encodes at least three protein isoforms orthologous to the GTP-binding proteins human GNL1 (HSR1; OMIM:143024) and murine MMR1, as well as LSG1 in S. cerevisiae and many other eukaryotic and bacterial proteins; one alternative transcription unit of the C53H9.2 locus, C53H9.2a, has a natural nonsense transcript that is up-regulated in vivo by smg[-] mutations, indicating that C53H9.2 is a natural substrate for SMG-mediated nonsense suppresssion; C53H9.2 is required in mass RNAi assays for embryonic viability, normally rapid growth, and early embryonic nuclear positioning; since several other natural mRNA substrates of SMG suppression (e.g., rpl-3, rpl-8, rpl-10a, rpl-12) have protein products that are involved in translation, C53H9.2's protein products may function in translation as well, an inference supported by the observed role of LSG1 in cytoplasmic 60S ribosomal subunit biogenesis. C54A12.1 ptr-6;C54A12.1 Has strong similarity to several C. elegans proteins that may be related to H. sapiens NPC1 (involved in Niemann-Pick disease) C54A12.2 C54A12.2 Member of the rhodopsin family of G protein-coupled receptors (GPCR), has high similarity to uncharacterized C. elegans R12C12.3 C54A12.3 C54A12.3 Protein of unknown function C54A12.4 C54A12.4 Member of the Ras superfamily of GTP-binding proteins, has moderate similarity to ras homolog gene family member I (aplysia ras homolog I) (human ARHI), which negatively regulates cell growth and likely acts as a tumor suppressor RAS-related protein C54C6.1 rpl-37;C54C6.1 Member of the ribosomal protein L37 protein family 60S ribosomal protein L37; rpl-37 encodes a large ribosomal subunit L37 protein. C54C6.2 ben-1;C54C6.2 Beta tubulin tubulin; A beta-tubulin that confers benzimidazole sensitivity. C54C6.4 C54C6.4 Protein of unknown function C54C6.5 C54C6.5 Protein of unknown function C54C8.1 C54C8.1 Protein containing nuclear hormone receptor ligand-binding and C4-type zinc finger domains, has weak similarity to a region of the glucocorticoid receptor (mouse Nr3c1), which is a transcription factor that inhibits inflammation and regulates apoptosis Zinc finger, C4 type (two domains) C54C8.11 gly-15;C54C8.11 Member of the core-2 or I-branching enzyme family, which form blood group I-antigens or side-chains of O-glycans, has low similarity to core 2 beta-1,6-N-acetylglucosaminyltransferase (rat Gcnt1), which forms O-glycan branched structures beta-1,6-N-acetylglucosaminyltransferase like; gly-15 encodes a protein similar to 2/I N-acetylglucosaminyltransferase; gly-15 expressed only in cellular processes that are probably part of the secretory network of the G2 gland cells. C54C8.2 C54C8.2 Protein of unknown function, has high similarity to uncharacterized C. elegans F56H6.6 C54C8.3 C54C8.3 Member of the galactosyltransferase family, which transfer galactose to GlcNAc termini of growing oligosaccharides chains, has low similarity to UDP-Gal:betaGlcNAc beta 1 3-galactosyltransferase polypeptide 5 (beta 3 galactosyltransferase, human B3GALT5) C54C8.4 C54C8.4 Protein of unknown function, has moderate similarity to uncharacterized C. elegans F46F5.14 glycosyltransferase C54C8.5 C54C8.5 Protein with moderate similarity to beta-1,3-glucuronyltransferase 3 (glucuronosyltransferase I, human B3GAT3), which is a type II transmembrane protein that catalyzes the transfer of a glucuronic acid to a specific trisaccharide primer C54C8.6 C54C8.6 Protein with moderate similarity to C. elegans C17G10.5 gene product C54C8.7 C54C8.7 Member of the C-type lectin family, has similarity to human C-type mannose receptor MRC1, has similarity to D. melanogaster TOLLOID and TOLKIN proteins C-type lectin domain C54C8.9 C54C8.9 Protein of unknown function C54D1.1 C54D1.1 Member of the ABC transporter family, contains an ABC transporter transmembrane domain, has low similarity to P-glycoprotein (ATP-binding cassette subfamily B member 1) (mouse Abcb1b), which is a multidrug efflux pump multidrug-resistance protein; This gene encodes a protein predicted by Eisenberg and coworkers, with 52% accuracy, to be mitochondrial. C54D1.2 C54D1.2 Member of the C-type lectin family, has similarity to human secretory pancreatic stone protein PSP-S C-type lectin C54D1.3 ist-1;C54D1.3 Protein of unknown function ist-1 encodes a pleckstrin homology (PH) and phosphotyrosine binding (PTB) domain-containing insulin receptor substrate (IRS) homolog that negatively regulates lifespan and dauer development; IST-1 potentiates insulin-like signaling, although it is not absolutely required for such signaling under most conditions; in addition to acting through the AGE-1/PI3K branch of the insulin-like signaling pathway, IST-1 may also function in a parallel pathway to activate downstream protein-kinase Bs encoded by akt-1 and akt-2. C54D1.4 C54D1.4 Protein with high similarity to human ALDH8A1, which is an aldehyde dehyrdogenase that metabolizes a variety of aldehydes, including 9-cis-retinal, member of the aldehyde dehydrogenase family, which use NADP as a cofactor aldehyde dehydrogenase C54D1.5 C54D1.5 Member of the laminin protein family C54D1.6 bar-1;C54D1.6 Beta-catenin; strongly similar to human CTNNB1 protein, beta-1 catenin; binds POP-1 and activates Wnt target genes beta-catenin; a beta-catenin/armadillo homolog that affects vulva cell specification and cell migration; genetically interacts with wnt and let-60 ras signalling pathways, is expressed in P3. | a beta-catenin/armadillo homolog that affects vulva cell specification and cell migration; genetically interacts with wnt and let-60 ras signalling pathways, is expressed in P3.p through P8.p in the late L1/early L2 stage, and in the seam cells, cells in the somatic gonad and P12. C54D10.1 C54D10.1 Protein containing a glutathione S-transferase C-terminal domain, which may be involved in conjugation of reduced glutathione to various targets, has high similarity to uncharacterized C. elegans C54D10.2 glutathione S-transferase C54D10.10 C54D10.10 Protein containing two kunitz or bovine pancreatic trypsin inhibitor domains, has low similarity to uncharacterized C. elegans F35B12.6 serine protease inhibitor C54D10.2 C54D10.2 Protein containing a glutathione S-transferase C-terminal domain, which may be involved in conjugation of reduced glutathione to various targets, has high similarity to uncharacterized C. elegans C54D10.1 glutathione S-transferase C54D10.3 C54D10.3 Protein of unknown function, has moderate similarity to uncharacterized C. elegans C46H11.7 C54D10.4 C54D10.4 Protein of unknown function C54D10.5 C54D10.5 Protein of unknown function, has moderate similarity to uncharacterized C. elegans F20A1.2 C54D10.6 C54D10.6 Member of the 7-transmembrane chemoreceptor family of G protein-coupled receptors (GPCR), has low similarity to C. elegans H27D07.6 G-protein coupled receptor, srh family C54D10.7 C54D10.7 Putative coiled-coil protein C54D10.8 C54D10.8 Coiled-coil protein C54D10.9 C54D10.9 Protein of unknown function C54D2.1 C54D2.1 Protein containing an EB module domain C54D2.2 C54D2.2 Protein of unknown function C54D2.4 C54D2.4 Member of the sulfatase family, which hydrolyze sulfate esters, has low similarity to a region of arylsulfatase B (N-acetylgalactosamine 4-sulfatase, rat Arsb), which hydrolyzes sulfate ester groups from N-acetylgalactosamine 4-sulfate of dermatan sulfate sul-3 is orthologous to the human gene ARYLSULFATASE B (ARSB; OMIM:253200), which when mutated leads to mucopolysaccharidosis type VI. C54D2.5 cca-1;C54D2.5 Protein with high similarity to calcium channel voltage-dependent alpha 1H subunit (human CACNA1H), which is a pore-forming subunit of the low voltage-gated T-type calcium channel, member of the ion transport family Skeletal muscle calcium channel alpha-1 subunit; cca-1 encodes a low-voltage-activated (T-type) calcium channel; CCA-1 is required for normal pharyngeal pumping, and in conjunction with UNC-2, a high-threshold calcium channel (N- and P/Q-type), may also play a role in defecation and egg-laying; CCA-1 is expressed in the pharyngeal MC motor neuron, head neurons, the ventral nerve cord, the anterior-most body-wall muscles, and cells in the tail region. C54E10.1 C54E10.1 Protein of unknown function, has low similarity to uncharacterized C. elegans K06B9.4 C54E10.2 C54E10.2 Protein containing a putative EF-hand domain, has a region of low similarity to a region of kv4 channel-interacting protein 2 (rat Kcnip2), which may regulate Kv4 potassium channels via interaction with alpha subunits EF hand C54E10.3 C54E10.3 Putative ortholog of C. elegans C50H11.13 gene product C54E10.4 C54E10.4 Member of the 7-transmembrane chemoreceptor family of G protein-coupled receptors (GPCR), has high similarity to uncharacterized C. elegans T22H2.1 7TM chemoreceptor, sri family C54E10.5 C54E10.5 Protein containing two nuclear hormone receptor C4-type zinc finger domains, has low similarity to C. elegans NHR-58, which is involved in embryogenesis and morphogenesis Zinc finger, C4 type (two domains) C54E10.6 C54E10.6 Small protein containing a CHROMO (CHRromatin Organization MOdifier) domain and a coiled-coil region, has similarity to C. elegans CEC-1 C54E4.1 C54E4.1 Protein of unknown function C54E4.2 C54E4.2 Protein containing a thyroglobulin type-1 repeat, which may be involved in the control of proteolytic degradation C54E4.3 gcy-37;C54E4.3 Protein containing an adenylate and guanylate cyclase catalytic domain, has low similarity to rat Gucy1b2, which is the beta 2 subunit of the enzyme guanylate cyclase that converts GTP to cGMP guanylate cyclase; gcy-37 encodes a predicted soluble guanylyl cyclase that is expressed in four candidate sensory neurons connected to the pseudocoelom, URXL, URXR, AQR, and PQR; as loss of gcy-37 activity via RNA-mediated interference does not result in any abnormalities, the precise role of GCY-37 in C. elegans development and/or behavior is not yet known; GCY-37 expression in neurons connected to the pseudocoelom suggests, however, that GCY-37 may play a role in fluid homeostasis. C54E4.4 C54E4.4 Protein of unknown function C54E4.5 C54E4.5 Protein of unknown function, has a region of high similarity to a region of mouse Aldrl6, which is a cytoplasmic oxidoreductase C54F6.1 C54F6.1 Member of the 7-transmembrane chemoreceptor family of G protein-coupled receptors (GPCR), has moderate similarity to uncharacterized C. elegans F31F4.6 7TM chemoreceptor, srh family C54F6.10 C54F6.10 Member of the 7-transmembrane chemoreceptor family of G protein-coupled receptors (GPCR), has high similarity to uncharacterized C. elegans T27C4.3 7TM chemoreceptor, str family C54F6.11 C54F6.11 Protein with strong similarity to C. elegans C54F6.6 gene product 7TM chemoreceptor, srb family C54F6.12 C54F6.12 Protein of unknown function, has weak similarity to uncharacterized C. elegans F59E11.7 C54F6.13 C54F6.13 Member of the sodium or hydrogen exchanger family, which maintain the pH of actively metabolizing cells, has moderate similarity to solute carrier family 9 isoform 5 (sodium-hydrogen exchanger 5, human SLC9A5), which is a sodium-hydrogen antiporter nhx-3 encodes a sodium/proton exchanger expressed intracellularly (in elliptical, randomly distributed dots that might be multivesicular or Ward bodies) within hypodermal cells of the main body syncytium, socket cells, and the excretory pore cell, as well as (in adults) within uterine cells (probably ut1) in the region closest to the vulva, in spermathecal junction cells; nhx-3 has no obvious phenotype in mass RNAi screens; NHX-3 is thought to prevent intracellular acidification by catalysing the electroneutral exchange of vesicular sodium for an intracellular proton; speculatively, NHX-3 might enable hypodermis-specific secretion of cuticle or phagocytosis. C54F6.14 C54F6.14 Protein with high similarity to ferritin heavy chain (mouse Fth), which is an iron-storage protein that has roles in iron homeostasis and metabolism, member of the ferritin family of non-heme iron storage proteins ferritin heavy chain; ftn-1 encodes a protein with homology to human ferritin heavy chain (feriitin H subunit). C54F6.3 C54F6.3 Protein of unknown function, has high similarity to uncharacterized C. elegans F49D11.3 C54F6.4 C54F6.4 Member of the MtN3-saliva family, which contain a region of two transmembrane helices, has moderate similarity to uncharacterized C. elegans K02D7.5 C54F6.5 C54F6.5 Protein of unknown function, has weak similarity to C. elegans C54F6.6 C54F6.6 C54F6.6 Protein with strong similarity to C. elegans C54F6.11 gene product C54F6.7 C54F6.7 Protein with strong similarity to C. elegans C54F6.11 gene product 7TM chemoreceptor, srb family C54F6.8 C54F6.8 Protein containing nuclear hormone receptor C4-type zinc finger and ligand-binding domains, has moderate similarity to C. elegans NHR-51, which is involved in developmental processes nuclear hormone receptor C54F6.9 C54F6.9 Protein containing a nuclear hormone receptor ligand-binding domain, has moderate similarity to C. elegans NHR-51, which is involved in developmental processes C54G10.1 C54G10.1 Protein of unknown function C54G10.2 C54G10.2 Member of the ATPase family associated with various cellular activities, has low similarity to replication factor C (activator 1, human RFC1), which is the large subunit of the DNA replication factor C complex replication factor C 140 KD subunit like C54G10.3 C54G10.3 Member of the ABC transporter family, has low similarity to ATP-binding cassette subfamily D (ALD) member 3 (human ABCD3), which is involved in the peroxisomal import of fatty acids and fatty acyl-CoAs and plays a role in peroxisome biogenesis peroxisomal membrane protein (PMP70) C54G10.4 C54G10.4 Member of the mitochondrial carrier protein family of membrane transporters, has moderate similarity to solute carrier family 25 member 20 (human SLC25A20), which functions in fatty acid oxidation and is associated with hypoglycemia and cardiac problems mitochrondrial carrier protein C54G4.1 C54G4.1 Protein with high similarity to ribosomal protein S6 kinase A5 (human RPS6KA5), contains two protein kinase C-terminal domains and a protein kinase domain Protein kinase C terminal domain C54G4.2 C54G4.2 Protein of unknown function, has moderate similarity to uncharacterized C. elegans C09G5.7 C54G4.3 C54G4.3 Protein of unknown function, has strong similarity to uncharacterized C. elegans F58D5.7 C54G4.4 C54G4.4 Protein with similarity to selectins of D. melanogaster (FW, furrowed) and human (SELE), member of the C-type lectin family sushi repeats C54G4.5 C54G4.5 Protein of unknown function C54G4.6 C54G4.6 Member of the Maf-like protein family, which may be inhibitors of septum formation, has low similarity to uncharacterized S. pombe Spac3G6.03cp MAF protein; This gene encodes a protein predicted by Eisenberg and coworkers, with 68% accuracy, to be mitochondrial. C54G4.7 C54G4.7 Protein of unknown function C54G4.8 C54G4.8 Putative cytochrome c1, predicted member of the cytochrome bc1 complex cytochrome C1, heme protein C54G4.9 C54G4.9 Protein of unknown function C54G6.1 C54G6.1 Protein of unknown function C54G6.2 C54G6.2 Protein of unknown function, has weak similarity in the C-terminus to human XRP2 (Hs.44766) The C54G6.2 gene encodes a homolog of human RP2, which when mutated leads to X-linked retinitis pigmentosa 2 (OMIM:312600). C54G6.3 C54G6.3 Protein with moderate similarity to C. elegans F49E12.7 gene product C54G6.5 C54G6.5 Protein with strong similarity to C. elegans Y34D9A.G gene product C54G7.1 C54G7.1 Protein with moderate similarity to C. elegans C09G5.8 gene product C54G7.2 C54G7.2 Member of the membrane bound O-acyl transferase (MBOAT) family, which are found in acyltransferase enzymes, has moderate similarity to uncharacterized C. elegans C08F8.4 C54G7.3 lgx-1;C54G7.3 Protein containing 13 EB module domains, has weak similarity to uncharacterized C. elegans F46C8.4 lgx-1 encodes a protein with eight EB modules (worm-specific domains, containing eight conserved cysteines that probably form four disulphide bridges, that are of unknown function) and a glutamine/asparagine (Q/N)-rich domain. C54G7.4 C54G7.4 Protein containing three WD domains (WD-40 repeat), which may mediate protein-protein interactions C54H2.1 C54H2.1 Protein of unknown function sym-3 encodes a novel protein that has no recognizably conserved domains, but does have homologs in Drosophila, mouse, and human; mutations in sym-3, while producing no phenotype on their own, are synthetically lethal with loss-of-function mutations in mec-8, which encodes a regulator of alternative RNA splicing; although the precise function of sym-3 is not yet known, sym-3 activity appears to be required for some aspects of pharyngeal differentiation, as mec-8; sym-3 double mutants arrest as late-stage embryos or L1 larvae with pharynges that, despite normal morphology, do not attach to the outer cuticle to allow for feeding. C54H2.2 C54H2.2 Member of the transposase family, which are required for excising and inserting mobile genetic elements, has very strong similarity to uncharacterized C. elegans C06B8.5 transposase C54H2.3 C54H2.3 Member of the zinc finger in Ran binding proteins family, which may be involved in nuclear transport C54H2.4 C54H2.4 Protein of unknown function C54H2.5 sft-4;SURF-4;C54H2.5 Protein with high similarity to surfeit gene 4 (mouse Surf4), which is an integral membrane protein predicted to have housekeeping roles, member of the SURF4 (surfeit locus) family sft-4 encodes a member of the SURF family highly conserved with the mouse Surf-4 gene, and conservation includes an encoded dilysine motif that is implicated in endoplasmic reticulum localization of the mouse protein. C55A1.1 C55A1.1 Member of the 7-transmembrane chemoreceptor family of G protein-coupled receptors (GPCR), has high similarity to uncharacterized C. elegans Y102A5C.28 C55A1.10 C55A1.10 Member of the 7-transmembrane chemoreceptor family of G protein-coupled receptors (GPCR), has moderate similarity to uncharacterized C. elegans F57G8.1 C55A1.11 F53E4.1;C55A1.11 Protein containing six Kelch motif domains, has low similarity to a region of S. pombe Tea1p, which is required for the initiation of bipolar growth and for the correct localization of growing tips C55A1.2 C55A1.2 Protein with strong similarity to C. elegans K04C1.6 gene product C55A1.3 C55A1.3 Member of the 7-transmembrane chemoreceptor family of G protein-coupled receptors (GPCR), has low similarity to C. elegans ODR-10, which is a G protein-coupled receptor involved in odorant response C55A1.4 C55A1.4 Protein of unknown function, has very strong similarity to uncharacterized C. elegans C55A1.7 C55A1.5 C55A1.5 Member of the 7-transmembrane chemoreceptor family of G protein-coupled receptors (GPCR), has low similarity to C. elegans ODR-10, which is involved in odorant response C55A1.6 C55A1.6 Protein of unknown function, has high similarity to uncharacterized C. elegans F14D7.7 C55A1.7 C55A1.7 Protein of unknown function, has very strong similarity to uncharacterized C. elegans C55A1.4 C55A1.8 C55A1.8 Protein containing a DUF215 domain of unknown function, has moderate similarity to uncharacterized C. elegans R07B5.4 C55A1.9 C55A1.9 Protein of unknown function, has high similarity to uncharacterized C. elegans ZK380.4 C55A6.1 C55A6.1 Protein with weak similarity to C. elegans C26B9.6 Zinc finger, C3HC4 type (RING finger) C55A6.10 C55A6.10 Protein of unknown function C55A6.2 C55A6.2 Member of the tubulin-tyrosine ligase family Human KIAA0173 protein like C55A6.3 C55A6.3 Member of the alcohol dehydrogenase protein family dehydrogenase C55A6.4 C55A6.4 Member of the alcohol dehydrogenase protein family alcohol dehydrogenase C55A6.5 C55A6.5 Member of the alcohol/ribitol dehydrogenase-like protein family alcohol dehydrogenase C55A6.6 C55A6.6 Member of the alcohol/ribitol dehydrogenase-like protein family alcohol dehydrogenase C55A6.7 C55A6.7 Member of the alcohol/ribitol dehydrogenase-like protein family alcohol dehydrogenase C55A6.8 C55A6.8 Protein of unknown function, has high similarity to uncharacterized C. elegans C55A6.6 dehydrogenase C55A6.9 C55A6.9 Protein with weak similarity to S. cerevisiae Paf1p (protein associated with RNA polymerase II), has similarity to human HS.152894 C55B6.1 C55B6.1 Protein containing an FGGY family of carbohydrate kinases C-terminal domain and an N-terminal domain, has weak similarity to glycerol kinase (mouse Gk), which catalyzes the phosphorylation of glycerol to glycerol 3-phosphate glycerol kinase C55B6.2 C55B6.2 Protein with high similarity to protein kinase inhibitor p58 (human DNAJC3), which may act as a cochaperone that inhibits double-stranded RNA-dependent protein kinase (human PRKR), contains a DnaJ and six TPR (tetratrico peptide repeat) domains This gene encodes a protein containing a DnaJ ('J') domain that is predicted to be mitochondrial. C55B6.3 C55B6.3 Protein of unknown function C55B6.4 C55B6.4 Protein of unknown function C55B6.5 C55B6.5 Protein containing a protein kinase domain C55B7.1 glh-2;C55B7.1 Putative RNA helicase in the germ line and localized to P granules; putative ortholog of S. cerevisiae DBP1 gene product [ATP-dependent RNA helicase of the DEAD box family] RNA helicase; glh-2 encodes a putative DEAD-box RNA helicase that contains six CCHC zinc fingers and is homologous to Drosophila VASA, a germ-line-specific, ATP-dependent, RNA helicase; at non-permissive temperatures, GLH-2 plays a role in germ-line development and fertility, specifically in regulating the normal extent of germ-line proliferation, oogenesis, and the production of functional sperm; GLH-2 activity may also be required for the wild-type morphology of P granules and for localization of several protein components, but not accumulation of P granule mRNA components; GLH-2 interacts in vitro with itself and with KGB-1, a JNK-like MAP kinase; GLH-2 is a constitutive P granule component and thus, with the exception of mature sperm, is expressed in germ cells at all stages of development; GLH-2 is cytoplasmic in oocytes and the early embryo, while perinuclear in all later developmental stages as well as in the distal and medial regions of the hermaphrodite gonad; GLH-2 is expressed at barely detectable levels in males. C55B7.10 C55B7.10 Protein containing two protein kinase domains, has low similarity to casein kinase 1 alpha 1 (rat Csnk1a1), which is a serine-threonine protein kinase that may play a role in signal transduction casein kinase C55B7.11 C55B7.11 Protein with moderate similarity to C. elegans F27C8.5 gene product C55B7.12 C55B7.12 Protein containing four C2H2 type zinc finger domains, has a region of high similarity to a region of zinc-finger protein 91 (human ZNF91), which functions as a transcriptional repressor and may play a role in formation of seminomas zinc finger prtoein; che-1 encodes a C2H2-type zinc finger-containing transcription factor orthologous to Drosophila GLASS, which is required for photoreceptor cell differentiation; CHE-1 is required for determining the identity and function of the amphid ASE neurons, the major neurons that mediate chemotaxis to water-soluble attractants; CHE-1 is expressed predominantly in the ASE neurons and regulates, either directly or indirectly, the expression of a number of ASE-specific genes. C55B7.2 gly-2;C55B7.2 Protein with moderate similarity to n-acetylglucosaminyltransferase V (human MGAT5), which catalyzes beta-1 6 branching on N-linked carbohydrates and may play a role in tumor invasiveness alpha-1,3(6)-mannosylglycoprotein beta-1,6-N-acetyl-glucosaminyltransferase; gly-2 encodes a functional homolog of mammalian UDP-N-acetylglucosamine alpha-6-d-mannoside beta-1,6-N-acetylglucosaminyltransferase V (GlcNAc-TV) which regulates polylactosamine-containing N-glycans; gly-2 is functionally interchangeable with the mammalian gene; GLY-2 is expressed in late embryos and in a subset of neurons in larvae, spermathecal and pharyngeal-intestinal valves and in specific vulval cells of adults. C55B7.3 F10G8.1;C55B7.3 Putative tyrosine protein phosphatase protein-tyrosine phosphatase C55B7.4 C55B7.4 Member of the acyl-CoA dehydrogenase protein family acyl-CoA dehydrogenase C55B7.5 C55B7.5 Protein of unknown function C55B7.6 C55B7.6 Protein with moderate similarity to sulfate transporters C55B7.7 C55B7.7 Protein with similarity to human Hs.3830 gene product, protein KIAA0893 isolated from a brain cDNA library C55B7.8 dbr-1;Ce-dbr1;C55B7.8 Functional ortholog of S. cerevisiae Dbr1p, lariat RNA debranching enzyme lariat debranching enzyme; dbr-1 encodes a homolog of the RNA lariat-debranching enzyme; DBR-1 is predicted to function in RNA processing by hydrolyzing the 2'-5' phosphodiester bond at the branchpoint of excised lariat intron RNA, thus converting the introns into linear molecules that can subsequently be degraded by exonucleases; in C. elegans, DBR-1 activity is required for embryonic and germline development, as well as for normal rates of postembryonic growth; overexpression of C. elegans DBR-1 in Saccharomyces cerevisiae can complement the RNA processing defects of a dbr1 null mutant strain, restoring debranching activity and intron degradation to near wild-type levels. C55B7.9 C55B7.9 Protein of unknown function, has low similarity to uncharacterized human FLJ20045 C55C2.1 C55C2.1 Protein containing three C2H2 type zinc finger domains, has a region of high similarity to a region of zinc finger protein 293 (mouse Zfp293), which is a Snail-related transcriptional repressor that regulates basic helix-loop-helix transcription factors zinc-finger transcription factor C55C2.2 C55C2.2 Protein containing a major sperm protein (MSP) domain, which are involved in sperm motility, has strong similarity to uncharacterized C. elegans K07F5.9 C55C2.3 C55C2.3 Protein of unknown function, has low similarity to uncharacterized C. elegans C55C2.4 C55C2.4 C55C2.4 Protein of unknown function, has low similarity to uncharacterized C. elegans C55C2.3 C55C2.5 C55C2.5 Member of the amino acid permease family of membrane transporters, has low similarity to solute carrier family 7 member 11 (human SLC7A11), which is a high affinity cystine and glutamate transporter amino acid permease C55C3.1 C55C3.1 Protein containing lipopolysaccharide-binding protein, bactericidal permeability-increasing protein, or cholesteryl ester transfer protein N-terminal and C-terminal domains, has weak similarity to uncharacterized C. elegans F01G10.1 C55C3.2 C55C3.2 Protein of unknown function, has weak similarity to C. elegans C27A2.1 C55C3.3 C55C3.3 Protein of unknown function, has strong similarity over N-terminal 252 amino acids to C. elegans F23B2.7 C55C3.4 C55C3.4 Protein containing a protein kinase domain and a Src homology 2 (SH2) domain, has moderate similarity to fer (fps/fes related) tyrosine kinase (mouse Fert2), which may mediate cell-cell signaling and cell size-dependent cytoskeletal reorganization tyrosine-protein kinase C55C3.5 C55C3.5 Protein of unknown function C55C3.6 C55C3.6 Putative ortholog of C. elegans F23B2.7 gene product C55F2.1 C55F2.1 Protein with high similarity to 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase and IMP cyclohydrolase (human ATIC), member of the AICARFT or IMPCHase bifunctional enzyme family, contains two methylglyoxal synthase (MGS)-like domains transferase C55F2.2 C55F2.2 Protein of unknown function, has a region of moderate similarity to a region of C. elegans F22A3.6, which is a putative lysozyme involved in embryogenesis and morphogenesis C55H1.1 C55H1.1 Putative ortholog of C. elegans C10H11.3 gene product C55H1.2 gpa-10;C55H1.2 Member of the G protein alpha subunit family guanine nucleotide-binding protein; gpa-10 encodes a member of the G protein alpha subunit family of heterotrimeric GTPases; it is expressed in ADF, ASI, ASJ, ALN, CAN, LUA, and the spermatheca. C56A3.1 C56A3.1 Protein of unknown function containing a Ground-like domain, has weak similarity to C. elegans Y47D7A_146.B C56A3.2 C56A3.2 Member of the transthyretin-like family, has high similarity to uncharacterized C. elegans T07C12.7 Transthyretin-like family C56A3.3 C56A3.3 Protein of unknown function, has low similarity to uncharacterized C. elegans T14C1.1 7tm receptor; C56A3.3 encodes a homolog of the functionally active Fmrf Receptor (FR; CG2114) of D. melanogaster; it is thus possible that C56A3.3 is a receptor for one of the FMRF-like neurotransmitters in C. elegans (e.g., FLP-1 through FLP-12). C56A3.4 C56A3.4 Protein with weak similarity to H. sapiens Hs.32316 (Homo sapiens mRNA for KIAA0544 protein, partial cds) Zinc finger, C3HC4 type (RING finger) C56A3.5 C56A3.5 Protein of unknown function C56A3.6 C56A3.6 Protein containing four EF hand domains, has low similarity to a region of calcium binding atopy-related autoantigen 1 (human CBARA1), which is an intracellular protein that acts as an IgE-binding antigen and is involved in the immune response EF hand (2 domains) C56A3.7 cav-2;C56A3.7 Member of the caveolin family, which are major membrane components of cavoleae, has a region of low similarity to caveolin 1 (mouse Cav), which is a tumor suppressor and structural component of caveolar membranes that is involved in signal transduction Caveolin; cav-2 encodes one of two C. elegans proteins related to caveolins, integral transmembrane proteins that are believed to function in regulation of signal transduction and that are the major component of caveolae, specialized lipid rafts found in the plasma membrane of most cell types; as loss of cav-2 function via large-scale RNA-mediated interference (RNAi) screens does not result in any obvious abnormalities, the role of cav-2 in C. elegans development and/or behavior is not yet known; cav-2 mRNA is expressed in eggs and mixed stage populations. C56A3.8 C56A3.8 Protein with moderate similarity to phosphatidylinositol 4-kinase type II (rat Pi4kii), which is a membrane-bound phosphatidylinositol kinase that may be involved in glucose transport and T cell activation C56C10.1 C56C10.1 Member of the Sec 1 family, which may be involved in secretion, has weak similarity to vacuolar sorting protein 33a (rat Vps33a), which may be involved in vesicular transport from endosomes to lysosomes C56C10.10 C56C10.10 Protein containing two TPR (tetratrico peptide repeat) domains, which may mediate protein-protein interactions, has low similarity to aryl hydrocarbon receptor interacting protein (human AIP), which binds unliganded Ah receptor (human AHR) and HSP90 TPR domain C56C10.11 C56C10.11 Large protein of unknown function, contains a DnaJ domain DNAJ protein C56C10.12 C56C10.12 Protein of unknown function, has weak similarity to uncharacterized human KIAA1632 C56C10.13 C56C10.13 Protein with moderate similarity to C. elegans Y47H9C.5 gene product This gene encodes a protein containing a DnaJ ('J') domain. C56C10.3 C56C10.3 Protein of unknown function, has high similarity to C. elegans C37C3.3 C56C10.4 C56C10.4 Protein containing a DB module domain, has high similarity to uncharacterized C. elegans C42D4.3 C56C10.5 C56C10.5 Protein of unknown function, has high similarity to uncharacterized C. elegans F18C5.8 7TM chemoreceptor, sra family C56C10.6 C56C10.6 Protein containing a protein kinase domain, has low similarity to casein kinase 1 gamma 3 (rat Csnk1g3), which is a serine-threonine protein kinase that may play roles in cell growth and in morphogenesis Casein kinase C56C10.7 C56C10.7 Protein of unknown function C56C10.8 C56C10.8 Protein with high similarity to basic transcription factor 3 (human BTF3), which complexes with RNA polymerase II and that is required for transcriptional initiation, contains a nascent polypeptide-associated complex (NAC) alpha protein domain Transcription factor BTF3 (human) C56C10.9 C56C10.9 Protein containing six EF hand domains, has low similarity to reticulocalbin 2 (human RCN2), which is an endoplasmic reticulum calcium-binding protein that interacts with the papillomavirus E6 oncoprotein C56E10.1 C56E10.1 Protein containing a nuclear hormone receptor C4-type zinc finger domain, which bind DNA and may be involved in regulation of transcription, and a nuclear hormone receptor ligand-binding domain, has low similarity to uncharacterized C. elegans NHR-60 steroid zinc finger C56E10.2 C56E10.2 Protein of unknown function C56E10.3 C56E10.3 Coiled-coil protein, has weak similarity to myosin heavy chains C56E10.4 C56E10.4 Protein containing a nuclear hormone receptor ligand-binding domain and a nuclear hormone receptor C4-type zinc finger domain, which bind DNA and may be involved in regulation of transcription C56E6.1 C56E6.1 Protein of unknown function, has a region of low similarity to a region of sterolin 1 (human ABCG5), which may be an ATP-binding cassette (ABC) transporter and is associated with sitosterolemia, hypercholesterolemia, and premature coronary atherosclerosis C56E6.2 C56E6.2 Member of the Ras superfamily of GTP-binding proteins, has a region of moderate similarity to S. cerevisiae Ypt6p, which is a GTP-binding protein involved in the secretory pathway GTP-binding C56E6.3 C56E6.3 Protein with moderate similarity to C. elegans C02E7.10 gene product C56E6.4 C56E6.4 Protein of unknown function C56E6.5 C56E6.5 Member of the ABC transporter family, has weak similarity to ATP-binding cassette subfamily G member 2 (breast cancer resistance protein) (human ABCG2), which is a phospholipid and cholesterol transporter involved in developing multidrug resistance ATP-binding C56E6.6 C56E6.6 Protein containing leucine rich repeats, which mediate protein-protein interactions, has a region of low similarity to a region of toll-like receptor 3 (mouse Tlr3), which is involved in inflammatory response, response to viruses, and cell proliferation leucine-rich repeats C56G2.1 C56G2.1 Protein containing a KH domain and a tudor domain, has a region of low similarity to a region of a kinase anchor protein (mouse Akap), which anchors protein kinase A to subcellular locations C56G2.15 C56G2.15 Protein containing an acetyltransferase (GNAT) domain, has low similarity to a region of human FUS2, which has N-acetyltransferase activity and is a putative tumor suppressor C56G2.3 C56G2.3 Protein of unknown function, has low similarity to uncharacterized C. elegans F46F11.10 C56G2.4 C56G2.4 Member of the phosphatidylethanolamine-binding protein family, which may be involved in membrane remodeling during growth and maturation C56G2.5 C56G2.5 Protein containing a putative protein kinase domain, has similarity across the middle region to human protein kinase C-like proteins PRKCL1 and PRKCL2 and to C. elegans serine/threonine protein kinase F46F6.2 Protein kinase C56G2.6 C56G2.6 Possible estradiol 17 beta-dehydrogenase, member of a protein family let-767 encodes a short-chain dehydrogenase, reported to be required for efficient cholesterol metabolism; LET-767 is predicted to be required for the metabolism of a sterol and to be mitochondrial. C56G2.7 C56G2.7 Protein of unknown function, has a region of low similarity to integral plasma membrane glycoprotein (rat Gp110), which is a type I transmembrane glycoprotein that mediates Ca2+ -independent cell-cell adhesion C56G2.8 C56G2.8 Protein of unknown function C56G3.1 C56G3.1 Member of the rhodopsin family of G protein-coupled receptors (GPCR), has weak similarity to neuropeptide Y-Y2 receptor (human NPY2R), which signals through intracellular cAMP levels and calcium flux G-protein coupled receptors (family 1) C56G3.2 C56G3.2 Member of the aldo-keto reductase family, which include some related monomeric NADPH-dependent oxidoreductases, has high similarity to uncharacterized C. elegans C07D8.6 aldo/keto reductase family C56G7.1 mlc-4;C56G7.1 Putative non-muscle myosin light chain myosin regulatory light chain 2 C56G7.2 C56G7.2 Protein of unknown function, has weak similarity to C. elegans T22G5.3 This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins. C56G7.3 C56G7.3 Protein of unknown function CAT2 ctl-1;cat2 Cytosolic catalase CC4.2 nlp-15;CC4.2 Protein with moderate similarity to C. elegans D1009.4 gene product CC4.3 smu-1;CC4.3 Protein that may be involved in splice site selection in alternative mRNA splicing WD domain, G-beta repeats (2 domains) CC8.1 CC8.1 Protein of unknown function CC8.2 CC8.2 Putative paralog of C. elegans F15G10.1 CD4.1 CD4.1 Protein of unknown function CD4.2 CD4.2 Member of the TatD-related DNase family, has low similarity to uncharacterized human CDA11 crn-2 encodes a cell death-related nuclease, homologous to the magnesium-dependant TatD nuclease of E. coli; CRN-2 is required for normal levels of DNA degradation during apoptosis; crn-2(RNAi) 1.5-fold stage embryos display TUNEL labelling of nuclei that is five-fold higher than that seen in untreated N2 animals; CRN-2 promotes both DNA degradation and cell corpse engulfment, in a partially redundant pathway that includes CRN-3 but is parallel to CPS-6; CRN-2 is predicted to be mitochondrial. CD4.3 CD4.3 Possible large ribosomal subunit protein CD4.4 CD4.4 Protein of unknown function, has weak similarity to D. melanogaster EG:115C2.5 CD4.5 CD4.5 Protein with strong similarity to C. elegans T19B10.9 gene product CD4.6 pas-6;CD4.6 Putative alpha-type subunit of 20S proteasome particle protease; pas-6 encodes a type 1 alpha subunit of the 26S proteasome's 20S protease core particle (CP); PAS-6 is required for embryonic, larval, and germline development and by homology, is predicted to comprise the outer rings of the proteasome and to play a role in selective degradation of ubiquitinated proteins during development; in vitro, PAS-6 interacts with BRP-1, a glutamine/asparagine (Q/N)-rich domain-containing protein conserved amongst nematodes, and with other members of the proteasome. CD4.7 CD4.7 Protein of unknown function CD4.8 CD4.8 Protein of unknown function, has high similarity to uncharacterized C. elegans T28A8.6 CD4.9 CD4.9 Protein containing a low-density lipoprotein (LDL) receptor class A domain CDK-7 cdk-7 Protein with high similarity to cyclin-dependent protein kinase 7 (human CDK7), which is a component of CDK-activating kinase (CAK) that is a subunit of polymerase II transcription initiator TFIIIH, contains a protein kinase domain CE-FKH-1 pha-4;fkh-1;Ce-fkh-1 Specifies the pharyngeal cell fate CE-SEMA-2A mab-20;Ce-Sema-2a Putative member of Ig superfamily that is required for cell guidance and migration CED6.1 C17G10.8;fat-3;Ced6.1 Member of the alcohol/ribitol dehydrogenase-like protein family CEHD-28 Cehd-28 Putative tyrosine protein kinase CEHD-39 Cehd-39 Putative tyrosine protein kinase CEKRP85 krp85;CeKRP85 Motor subunit of the heterotrimeric CeKinesin-II motor complex CHP-1 chp-1 CHORD domain containing protein that appears to be required for early embryonic development as well as later development of the hermaphrodite vulva and germ cells CLH-3 clh-3 Chloride channel protein, clc-5 paralogue COI COX1;coi Protein with high similarity to mitochondrial cytochrome c oxidase subunit I (human MTCO1), which is a respiratory chain complex IV subunit associated with mitochondrial disease and anemia, member of the cytochrome C oxidase polypeptide I family COII COX2;coii Protein containing cytochrome C oxidase subunit II periplasmic and transmembrane domains, has moderate similarity to mitochondrial cytochrome c oxidase II (human MTCO2), which is associated with myopathy, lactic acidosis, epilepsy, and Alzheimer's disease COIII COX3;coiii Member of the cytochrome C oxidase subunit III family, has moderate similarity to human MTCO3, which regulates assembly and maintenance of the oxidase complex and is associated with Leigh-like syndrome and Leber's hereditary optic neuropathy COL-40 col-40 Collagen of the COL-6 family of collagens CSP-3 csp-3 Protein containing an interleukin-1 beta converting enzyme (ICE)-like protease (caspase) p10 domain, has low similarity to a region of C. elegans CED-3, which is an aspartate-specific cysteine protease that is involved in the induction of apoptosis CTEL54X.1 CTEL54X.A;CTEL54X.1 Protein containing a DUF38 domain of unknown function and an F-box domain, which serve as a link between a target protein and a ubiquitin-conjugating enzyme, has weak similarity to C. elegans FOG-2, which is required for the sexual identity of germ cells This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins; this gene's encoded protein also contains an FTH/DUF38 motif, which may also mediate protein-protein interaction. CTEL7X.A CTEL7X.1;CTEL7X.A Protein with moderate similarity to C. elegans F52C9.8 gene product CUC-1 cuc-1 Copper chaperone co-expressed with CUA-1 copper-transporting ATPase CYK-3 cyk-3 Mutations in this protein prevent completion of mitosis CYTB CYB;Cytb Protein containing a cytochrome b N-terminal domain and a cytochrome b C-terminal domain, has moderate similarity to mitochondrial cytochrome b (rat mt-Cytb), which is a subunit of mitochondrial complex III involved in cation transport D1005.1 D1005.1 Protein with high similarity to ATP citrate lyase (human ACLY), which is involved in cholesterol and fatty acid synthesis, member of the ATP-citrate lyase or succinyl-CoA ligase family, contains one CoA binding domain, which have a Rossmann fold ATP citrate lyase; This gene encodes a protein predicted by Eisenberg and coworkers, with 52% accuracy, to be mitochondrial. D1005.2 D1005.2 Member of the UTP-glucose-1-phosphate uridylyltransferase family, which catalyze formation of UDP-glucose, has moderate similarity to UDP-glucose pyrophosphorylase 2 (human UGP2), which forms UDP-glucose from glucose-1-phosphate and MgUTP D1005.3 D1005.3 Protein of unknown function, has high similarity to uncharacterized C. elegans Y44E3B.1 D1005.4 D1005.4 Protein of unknown function D1005.5 D1005.5 Protein of unknown function, has low similarity to uncharacterized C. elegans F15H10.6 D1005.6 D1005.6 Protein of unknown function D1007.1 ceh-17;ceh-42;CePhox2;D1007.1 Homeodomain transcription factor that promotes longitudinal growth of axons in certain neurons (609717) :715448 homeobox protein; ceh-17 encodes a phox-2-like homeodomain protein that is a member of the Q50 paired-like class of homeobox proteins and the vertebrate orthologue of Phox2a and Phox2b; that affects ALA and SIA axonal development; ceh-17 affects ALA and SIA antero-posterior axonal growth and navigation, and is expressed in five neurons of the ring ganglia (ALA and the 4 SIAs) with strongest expression in embryos and in L1 stage larvae. D1007.10 D1007.10 Protein of unknown function D1007.11 D1007.11 Protein of unknown function D1007.12 rpl-24;D1007.12 Member of the ribosomal L24e family, which are part of the large ribosomal subunit, has moderate similarity to ribosomal protein L24A (S. cerevisiae Rpl24ap), which is a structural ribosomal protein 60S ribosomal protein L24; rpl-24.1 encodes a large ribosomal subunit L24 protein. D1007.13 D1007.13 Protein of unknown function D1007.14 D1007.14 Protein of unknown function The protein product of this gene is predicted to contain a glutamine/asparagine (Q/N)-rich ('prion') domain, by the algorithm of Michelitsch and Weissman (as of the WS77 release of WormBase, i.e., in wormpep77). D1007.15 D1007.15 Protein of unknown function, has low similarity to uncharacterized human KIAA0195 D1007.16 D1007.16 Protein of unknown function, has weak similarity to C. elegans W09G12.7 D1007.2 D1007.2 Protein containing two collagen triple helix repeats, which are found in some extracellular proteins, has a region of moderate similarity to a region of C. elegans BLI-1 D1007.3 D1007.3 Protein of unknown function D1007.4 D1007.4 Protein of unknown function D1007.5 D1007.5 Protein of unknown function, has low similarity to uncharacterized human FLJ10902 D1007.6 rps-10;D1007.6 Protein with high similarity to ribosomal protein S10 (human RPS10), which is a component of the small 40S ribosomal subunit that is likely to play a role in translation initiation and may be associated with colorectal carcinogenesis 40S ribosomal protein S10; rps-10 encodes a small ribosomal subunit S10 protein. D1007.7 D1007.7 Protein containing an RNA recognition motif (RRM, RBD, or RNP), has low similarity to a region of human KIAA1116, which is a CTD-binding SR-like protein that functions in RNA processing RNA-binding protein D1007.8 D1007.8 Protein of unknown function D1007.9 D1007.9 Protein of unknown function D1009.1 D1009.1 Protein with high similarity to C. elegans ceFATPa, which is a fatty acid transport protein, member of the AMP-binding enzyme family fatty acid transporter protein D1009.2 cyp-8;D1009.2 Cyclophilin-related peptidylprolyl cis-trans-isomerase cyp-8 encodes a peptidyl-propyl cis-trans isomerase of the cyclophilin family; cyclophilins are implicated in protein folding, however the precise role of cyp-8 is not known; a CYP-8-fusion protein localises specifically to gut cell nuclei. D1009.3 D1009.3 Protein containing a beta or gamma fibrinogen C-terminal globular domain, has a region of low similarity to a region of angiopoietin 4 (mouse Agpt4), which is specific to the vascular endothelium and functions as a mouse Tek antagonist D1009.4 D1009.4 Protein with moderate similarity to C. elegans nlp-15 gene product D1009.5 D1009.5 Small protein with strong similarity over the C-terminus to human and D. melanogaster t-complex-associated-testis-expressed (TCTE1L and TCTEX) proteins D1014.1 D1014.1 Member of the sulfatase family, which hydrolyze sulfate esters, has low similarity to arylsulfatase F (human ARSF) arylsulfatase; sul-2 is orthologous to the human gene ARYLSULFATASE A (ARSA; OMIM:250100), which when mutated leads to metachromatic leukodystrophy. D1014.2 srq-5;D1014.2 Member of the rhodopsin family of G protein-coupled receptors (GPCR) D1014.3 D1014.3 Protein with high similarity to N-ethylmaleimide-sensitive factor (NSF) attachment protein alpha (human NAPA), which is involved in (Ca2+)-regulated membrane fusion and intra-Golgi transport, contains four aromatic-di-alanine (AdAR) repeat domains alpha-SNAP protein D1014.4 D1014.4 Protein of unknown function D1014.5 D1014.5 Protein containing a DUF138 domain of unknown function D1014.6 D1014.6 Protein containing a DUF138 domain of unknown function, has high similarity to uncharacterized C. elegans D1014.7 D1014.7 D1014.7 Protein containing a DUF138 domain of unknown function, has high similarity to uncharacterized C. elegans D1014.6 D1014.8 D1014.8 Protein containing two Myb-like DNA-binding domains and one Egl-27 and MTA1 homology 2 (ELM2) domain, which may be involved in DNA or protein-protein binding, has weak similarity to corepressor of REST (human RCOR) D1022.1 D1022.1 Member of the ubiquitin-conjugating enzyme (E2) family, has a region of moderate similarity to a region of ubiquitin-conjugating enzyme (S. cerevisiae Ubc6p), which is anchored in the ER membrane with the catalytically active domain in the cytoplasm Ubiquitin-conjugating enzyme D1022.2 D1022.2 Protein of unknown function D1022.3 D1022.3 Member of the dienelactone hydrolase family, has high similarity to uncharacterized C. elegans D1022.4 D1022.4 D1022.4 Member of the dienelactone hydrolase family, has high similarity to uncharacterized C. elegans D1022.5 D1022.5 D1022.5 Member of the dienelactone hydrolase family, has high similarity to uncharacterized C. elegans D1022.4 D1022.6 sro-1;D1022.6 Putative seven membrane receptor of the G protein-coupled receptor superfamily; possibly involved in chemosensation by sensory neurons G-protein coupled receptor D1022.7 AKAP;kap-1;D1022.7 Protein containing a FYVE zinc finger domain, which bind phosphatidylinositol 3-phosphate, has a region of weak similarity to a region of smad anchor for receptor activation (human MADHIP), which is involved in receptor-mediated activation of Smad aka-1 encodes an A kinase anchor protein that has mutiple isoforms, all of which have a zinc-finger domain of the FYVE type; interacts with KIN-2 in vitro. D1022.8 D1022.8 Protein containing two eukaryotic-type carbonic anhydrase domains, which catalyze reversible hydration of carbon dioxide, has low similarity to mitochondrial carbonic anhydrase VB (human CA5B), which may have a role in gluconeogenesis and ureagenesis Carbonic anhydrase; cah-2 encodes a predicted carbonic anhydrase. D1025.1 D1025.1 Protein of unknown function D1025.2 D1025.2 Protein with high similarity to glycine cleavage system protein H (human GCSH), which is the H-protein component of the glycine cleavage system that is associated with atypical nonketotic hyperglycinemia, member of the glycine cleavage H-protein family This gene encodes a protein predicted by Eisenberg and coworkers, with 52% accuracy, to be mitochondrial. D1025.3 D1025.3 Protein containing an F-box domain, which serve as a link between a target protein and a ubiquitin-conjugating enzyme, and a DUF38 domain of unknown function This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins; this gene's encoded protein also contains an FTH/DUF38 motif, which may also mediate protein-protein interaction. D1025.4 D1025.4 Protein of unknown function, has very strong similarity to uncharacterized C. elegans D1025.6 D1025.6 D1025.6 Putative ortholog of C. elegans D1025.4 gene product D1037.1 D1037.1 Protein with similarity to human SON DNA binding protein D1037.2 D1037.2;Ce-Sema-1b Protein with similarity to human putative DNA binding protein SON3, has similarity to two C. elegans putative semaphorins D1037.3 D1037.3 Putative ferritin, has strong similarity to human and D. melanogaster light-chain ferritins, probable paralog of C. elegans C54F6.14 ferritin; ftn-2 is orthologous to the human gene FERRITIN, HEAVY POLYPEPTIDE 1 (FTH1; OMIM:134770), which when mutated leads to disease. D1037.4 rab-8;D1037.4 GTP-binding protein of the rab family (ras superfamily); putative ortholog of human and D. melanogaster RAB8; has strong similarity to S. cerevisiae Ypt proteins of the rab family, involved in trans-golgi vesicular transport RAS-related protein; rab-8 encodes a rab related protein of the Ras GTPase superfamily that affects ovarian morphology and function, thereby affecting fertility; acts downstream of let-60 with respect to vulval development based on genetic analysis. D1037.5 D1037.5 Putative ortholog of C. elegans H23L24.2 gene product phospholipase D1043.1 D1043.1 Protein of unknown function D1044.1 D1044.1 Protein containing a DUF227 domain of unknown function, has low similarity to uncharacterized C. elegans H06H21.8 D1044.2 D1044.2 Protein of unknown function, has a region of low similarity to a region of alpha-tectorin (human TECTA), which is a major non-collagenous component of the tectorial membrane that may be involved in tectorial membrane matrix assembly D1044.3 D1044.3 Protein containing 16 EB module domains and a protein kinase domain, has a region of low similarity to NIMA (never in mitosis gene a)-related expressed kinase 6 (human NEK6), which activates the S6 ribosomal protein kinase p70S6K (RPS6KB1) The protein product of this gene is predicted to contain a glutamine/asparagine (Q/N)-rich ('prion') domain, by the algorithm of Michelitsch and Weissman (as of the WS77 release of WormBase, i.e., in wormpep77). D1044.4 D1044.4 Protein of unknown function D1044.5 D1044.5 Protein of unknown function D1044.6 D1044.6 Protein of unknown function, has moderate similarity to C. elegans C09G1.2 D1044.7 D1044.7 Putative ortholog of C. elegans D1044.3 gene product D1046.1 D1046.1 Protein with low similarity to cleavage and polyadenylation specific factor 6 (human CPSF6), which is a putative mRNA-binding protein that is the 68 kDa subunit of the mRNA cleavage factor Im (CF Im) complex and plays a role in pre-mRNA 3' end processing glycine-rich RNA-binding protein D1046.2 D1046.2 Protein containing a zinc finger domain of the C2H2 type Zinc finger, C2H2 type D1046.3 D1046.3 Member of the mitochondrial carrier protein family of membrane transporters, has low similarity to mitochondrial RNA splicing protein 4 (S. cerevisiae Mrs4p) mitochondrial carrier protein D1046.4 D1046.4 Protein with weak similarity to human sodium-dependent inorganic phosphate cotransporters, member of the major facilitator superfamily sodium/phosphate transporter D1046.5 D1046.5 Protein with strong similarity to C. elegans Y50C1A.2 gene product D1053.1 D1053.1 Protein with high similarity to glutathione transferase zeta 1 (human GSTZ1), which is a maleylacetoacetate isomerase and glutathione peroxidase associated with tyrosinemia, contains glutathione S-transferase N-terminal and C-terminal domains glutathione S-transferase; gst-42 is orthologous to the human gene GLUTATHIONE TRANSFERASE ZETA-1 (also known as MALEYLACETOACETATE ISOMERASE; GSTZ1; OMIM:603758), which when mutated is thought to lead to a variety of type I tyrosinemia. D1053.2 D1053.2 Putative ortholog of C. elegans F54F7.7 gene product D1053.3 D1053.3 Protein of unknown function D1054.1 D1054.1 Protein of unknown function, has moderate similarity to uncharacterized C. elegans B0524.E Human GS2 protein like D1054.10 D1054.10 Protein of unknown function D1054.11 D1054.11 Protein of unknown function D1054.12 D1054.12 Member of the 7-transmembrane chemoreceptor family of G protein-coupled receptors (GPCR), has moderate similarity to uncharacterized C. elegans K08G2.5 D1054.13 D1054.13 Protein of unknown function, has moderate similarity to uncharacterized soluble liver antigen/liver pancreas antigen (human LOC51091) D1054.14 D1054.14 Protein of unknown function, has moderate similarity to uncharacterized human FLJ14936 D1054.15 D1054.15 Protein with high similarity to human PLRG1, which interacts with a nuclear protein kinase C-beta II isoenzyme that is involved in insulin signaling, contains seven WD domain (WD-40 repeat), which may mediate protein-protein interactions beta transducin like protein D1054.2 pas-2;D1054.2 Putative alpha-type subunit of 20S proteasome particle proteasome component C3; pas-2 encodes a proteasome subunit with highest similarity to vertebrate proteasome alpha 2 subunits. D1054.3 D1054.3 Protein of unknown function, has low similarity to a region of S. pombe Git7p, which is involved in glucose-induced cAMP signaling D1054.5 D1054.5 Protein of unknown function D1054.6 D1054.6 Protein with strong similarity to C. elegans F16H6.2 gene product D1054.7 D1054.7 Member of the C-type lectin family, has weak similarity to human C-type mannose receptor MRC1 mannose receptor protein like D1054.8 D1054.8 Member of the short-chain dehydrogenase-reductase family, which are NAD- or NADP-dependent oxidoreductases, has low similarity to mouse H2-Ke6, which is a 17-beta dehydroxysteroid dehydrogenase that is involved in androgen and estrogen metabolism dehydrogenase; This gene encodes a protein predicted by Eisenberg and coworkers, with 68% accuracy, to be mitochondrial. D1054.9 D1054.9 Protein of unknown function D1065.1 D1065.1 Protein of unknown function, has high similarity to uncharacterized C. elegans F45F2.5 D1065.3 D1065.3 Protein containing a WSN domain of unknown function D1065.4 D1065.4 Member of the 7-transmembrane chemoreceptor family of G protein-coupled receptors (GPCR), has high similarity to uncharacterized C. elegans D1065.5 7TM chemoreceptor, srh family D1065.5 D1065.5 Member of the 7-transmembrane chemoreceptor family of G protein-coupled receptors (GPCR), has high similarity to uncharacterized C. elegans D1065.4 7TM chemoreceptor, srh family D1069.1 D1069.1 Protein of unknown function D1069.2 D1069.2 Protein containing a calponin homology (CH) domain, which bind actin, and a calponin family repeat, which consist of a well conserved 26 amino acid domain, has moderate similarity to a region of acidic calponin (rat Cnn3), which binds actin calponin; cpn-2 encodes a calponin homolog, more similar to the calponin paralogs transgelin (SM22 alpha) or neuronal protein NP25 than to calponin per se. D1069.3 D1069.3 Protein of unknown function D1069.4 D1069.4 Protein of unknown function, has moderate similarity to uncharacterized C. elegans Y48A6B.1 D1073.1 D1073.1 Protein containing two protein kinase domains, has a region of low similarity to a region of rat Ntrk3, which is a type 3 neurotrophic receptor protein tyrosine kinase (TrkC) that binds neurotrophin-3 (Ntf3) and may be involved in neuronal apoptosis tyrosine-protein kinase D1079.1 D1079.1 G protein-coupled receptor of unknown function, no homolog found in human or D. melanogaster D1081.2 D1081.2 Protein containing one SRF-type transcription factor (DNA-binding and dimerisation domain) domain, which are involved in transcriptional regulation, has a region of high similarity to a region of serum response factor (human SRF) MADS domain; unc-120 encodes a member of the MADS-box family of transcription factors that contains human and Drosophila serum response factor (SRF) and Saccharomyces cerevisiae MCM1 and ARG80; UNC-120 is required for locomotion and muscle development and for formation of the normal number of muscle A and I bands; UNC-120 is also required for maintaining wild-type expression levels of the muscle components actin and myosin; UNC-120 is first expressed in the early embryo in body wall muscle precursors and later is expressed in both body wall and vulval muscles. D1081.3 D1081.3 Protein with moderate similarity to C. elegans F15H9.1 gene product D1081.4 D1081.4 Protein of unknown function, has a region of moderate similarity to a region of C. albicans Rsr1p, which is a ras-related protein that is required for virulence and for morphogenesis of both yeast-form cells and hyphae guanine nucleotide binding domains D1081.5 D1081.5 Putative ortholog of C. elegans F54H5.5 gene product ankyrin motif D1081.6 D1081.6 Protein of unknown function D1081.7 D1081.7 Protein of unknown function D1081.8 D1081.8;Cdc5Ce Protein with high similarity to CDC5 (cell division cycle 5 S. pombe homolog)-like (human CDC5L), which is a transcriptional activator and non-snRNA spliceosome subunit involved in pre-mRNA splicing, contains two Myb-like DNA-binding domains MYB transforming protein D1081.9 D1081.9 Protein with weak similarity to C. elegans Y39B6.B D1086.1 D1086.1 Protein containing a DUF19 domain of unknown function, which contain twelve conserved cysteines D1086.2 D1086.2 Protein of unknown function D1086.3 D1086.3 Protein containing a DUF19 domain of unknown function, which contain twelve conserved cysteines D1086.4 D1086.4 Protein of unknown function D1086.5 D1086.5 Protein of unknown function, has weak similarity to C. elegans D1086.1 D1086.6 D1086.6 Protein of unknown function, has weak similarity to C. elegans D1086.7 D1086.7 D1086.7 Protein of unknown function, has weak similarity to C. elegans D1086.6 D2005.1 D2005.1 Protein containing one adenosine-deaminase (editase) domain, which deaminate adenosine residues on mRNA, has low similarity to a region of double-stranded RNA adenosine deaminase (rat Adarb1), which is involved in mRNA editing of the glutamate receptor RNA adenosine deaminase like D2005.2 D2005.2 GFxGF neurotransmitter D2005.3 D2005.3 Member of the DUF122 family of unknown function, has high similarity to uncharacterized mouse Pdcd5 D2005.4 D2005.4 Large protein of unknown function, has weak similarity over the C-terminus to a number of S. cerevisiae and C. elegans proteins, has weak similarity to several proteins of the human pathogen Plasmodium falciparum D2005.5 D2005.5 Member of the DEAD or DEAH box ATP-dependent RNA helicase family and contains a helicase conserved C-terminal domain, has a region of weak similarity to a region of C. elegans DCR-1, which is a helicase and RNase RNA helicase like D2005.6 D2005.6 Protein of unknown function D2007.1 D2007.1 Protein of unknown function D2007.2 D2007.2 Protein containing a major sperm protein (MSP) domain, which are involved in sperm motility D2007.2 is orthologous to the human gene TRANSKETOLASE (WERNICKE-KORSAKOFF SYNDROME) (TNF; OMIM:606781), which when mutated leads to disease. D2007.3 D2007.3 Protein of unknown function D2007.4 D2007.4 Possible large ribsomal subunit protein D2007.5 D2007.5 Protein of unknown function, has moderate similarity to H. sapiens Hs.79672 gene product D2013.1 D2013.1 Protein with high similarity to ras-related GTP-binding protein 2 (human RAB2), which is a GTPase that plays a role in vesicle transport from the ER to the Golgi and is associated with Searzy syndrome, member of the Ras superfamily of GTP-binding proteins GTP binding protein (YPT1 subfamily); rab-39 encodes a small, monomeric Rab GTPase that is most closely related to the human and Drosophila Rab39 GTPases; by homology, RAB-39 is predicted to function as a membrane-associated GTPase required for intracellular vesicular trafficking and for regulation of endo- and exocytosis; however, as loss of rab-39 function via RNA-mediated interference (RNAi) does not result in any obvious abnormalities, the precise role of RAB-39 in C. elegans development and/or behavior is not yet known. D2013.10 D2013.10 Protein of unknown function, has low similarity to uncharacterized human MGC15397 D2013.2 D2013.2 Protein containing five WD domains (WD-40 repeat), which may mediate protein-protein interactions, and a FYVE zinc finger domain, which bind phosphatidylinositol 3-phosphate, has moderate similarity to uncharacterized human WDF2 beta-transducin D2013.3 D2013.3 Protein containing three WD domains (WD-40 repeat), which may mediate protein-protein interactions D2013.4 cam-1;kin-8;Cehd-17;C01G6.8;D2013.4 Putative receptor tyrosine protein kinase, member of the ROR family of tyrosine receptor kinases of unknown function D2013.5 D2013.5 Protein containing an N-terminal dynamin family domain, which bind GTP, has a region of low similarity to a region of S. cerevisiae Mgm1p, which is a peripheral membrane protein that mediates mitochondrial inheritance GTP-binding protein; The eat-3 gene encodes a mitochondrial dynamin-related protein, closely related to bacterial dynamin-like proteins, that is orthologous to human OPA1 (OMIM:203740, mutated in autosomal dominant optic atrophy); EAT-3 is localized to the mitochondrial matrix and may play a role in regulating inner mitochondrial membrane morphology; EAT-3 is expressed in body wall muscle, intestine, and neurons, all tissues with high metabolic rates. D2013.6 D2013.6 Protein containing a GRAM domain, which are found in glucosyltransferases, myotubularins and other putative membrane-associated proteins, has low similarity to WW domain binding protein 2 (mouse Wbp2), which is a ligand involved in protein binding D2013.7 D2013.7 Protein with strong similarity to human eukaryotic translation initiation factor 3, subunit 5 (EIF3S5) M0V-34 protein D2013.8 scp-1;D2013.8 Protein containing four WD domains (WD-40 repeat), which may mediate protein-protein interactions, has low similarity to a region of SREBP cleavage-activating protein (human SCAP), which regulates cholesterol metabolism scp-1 encodes PTC-related protein that contains a sterol-sensing domain related to human Sterol regulatory element binding protein (SREBP) cleavage activating protein. D2013.9 D2013.9 Member of the tubulin-tyrosine ligase family, has low similarity to uncharacterized human KIAA0153 D2021.1 D2021.1 Protein containing five TPR (tetratrico peptide repeat) domains, which may mediate protein-protein interactions, and a Jumonji (jmjC) domain, has a region of weak similarity to ubiquitous tetratricopeptide repeat protein on the Y chromosome (human UTY) glucose repression mediator protein D2021.2 D2021.2 Protein containing a DHHC-type zinc finger (NEW1) domain, has a region of low similarity to a region of huntingtin interacting protein H (human HYPH), which interacts with human HD and this interaction may be altered in Huntington's disease D2021.4 D2021.4 Protein of unknown function D2021.8 D2021.8 Protein containing five ankyrin (Ank) repeats, which may mediate protein-protein interactions, has low similarity to prosome (human PSMD10, macropain), which is a non-ATPase subunit of the 26S proteasome ankyrin D2023.1 D2023.1 Protein containing one heme-binding domain, has a region of moderate similarity to a region of mitochondrial outer membrane ferrocytochrome b5 (rat Omb5), which is a heme binding protein that carrys out electron transfer reactions D2023.2 pyc-1;D2023.2 Protein with high similarity to pyruvate carboxylase 1 (S. cerevisiae Pyc1p), contains biotin or lipoyl attachment and biotin carboxylase C-terminal domains, carbamoyl-phosphate synthase L chain ATP binding and N-terminal domains, and an HMGL-like domain pyruvate carboxylase; pyc-1 encodes the C. elegans pyruvate carboxylase ortholog (OMIM:266150, deficiencies in humans are associated with lactic acidemia, neurological abnormalities, and early death); by homology, PYC-1 is predicted to function as a key regulatory enzyme of gluconeogenesis, lipogenesis, and anaplerosis, localizing to the mitochondrial matrix and catalyzing the formation of oxaloacetate from pyruvate and carbonate; however, loss of pyc-1 activity via large-scale RNAi screens does not result in any obvious abnormalities; pyc-1 expression is induced upon exposure of C. elegans to cadmium. D2023.3 D2023.3 Putative calcium-binding protein, has weak similarity to human SYT7 (rat synaptotagmin VII homolog) D2023.4 D2023.4 Protein containing an acetyltransferase (GNAT) domain, has low similarity to spermidine-spermine N1-acetyltransferase (mouse Sat), which catalyzes the rate limiting step of polyamine catabolism and promotes polyamine homeostasis diamine acetyltransferase D2023.5 D2023.5 Protein with low similarity to thiosulfate sulfotransferase (rhodanese, human TST), which is a thiosulfate sulfotransferase enzyme that functions in detoxification of cyanide thiosulphate sulphurtransferase D2023.6 D2023.6 Protein with moderate similarity to S. cerevisiae Abc1p, a possible chaperonin for the assembly of cytochrome bc1 complex Yeast ABC1 protein like; This gene encodes a protein predicted by Eisenberg and coworkers, with 52% accuracy, to be mitochondrial. D2023.7 D2023.7 Protein with high similarity to C. elegans ROL-6, which is involved in cuticle synthesis, contains two collagen triple helix repeats, which are found in some extracellular proteins, and a nematode cuticle collagen N-terminal domain collagen D2024.1 D2024.1 Protein containing a protein kinase domain, has low similarity to casein kinase 1 epsilon (human CSNK1E), which is a serine/threonine protein kinase that may function in DNA repair and is associated with familial advanced sleep phase syndrome D2024.2 D2024.2 Protein of unknown function, has moderate similarity to uncharacterized C. elegans Y45F10A.3 D2024.3 D2024.3 Member of the GNS1 or SUR4 family of integral membrane proteins, has a region of moderate similarity to polyunsaturated fatty acid (PUFA) elongase (C. elegans CEEl01), which contains the condensation activity required for fatty acid elongation The elo-3 gene encodes a paralog of elo-1 and elo-2, each of which encodes a polyunsaturated fatty acid (PUFA) elongase; ELO-3 may be required for normally rapid growth. D2024.4 D2024.4 Protein of unknown function D2024.5 D2024.5 Protein of unknown function D2024.6 cap-1;D2024.6 Protein with high similarity to capping protein muscle Z-line alpha 1 (human CAPZA1), which regulates actin polymerization and may contribute to barbed-end actin capping and cell motility, member of the F-actin capping protein alpha subunit family cap-1 encodes an F-actin capping protein alpha subunit that affects fertility; likely expressed in touch receptor neurons. D2024.7 D2024.7 Member of the 2-hydroxychromene-2-carboxylate isomerase protein family, which are involved in prokaryotic polyaromatic hydrocarbon (PAH) catabolism, has low similarity to uncharacterized C. elegans ZK1320.1 D2024.8 D2024.8 Protein containing two collagen triple helix repeats, which are found in some extracellular proteins, and a nematode cuticle collagen N-terminal domain, has a region of moderate similarity to a region of collagen type IX alpha 3 (human COL9A3) cuticle collagen D2024.9 D2024.9 Protein with strong similarity to C. elegans F35E8.5 gene product D2030.1 D2030.1 Protein with high similarity to mannosidase 1 alpha (mouse Man1a), which trims mannose residues and plays a role in misfolded protein degradation, member of the glycosyl hydrolase 47 family of alpha-mannosidases, which hydrolyze terminal mannose residues alpha 1,2 mannosidase precursor D2030.10 aex-1;D2030.10 Protein of unknown function AEX-1 is a novel C2 domain protein; C2 is a proposed calcium binding domain; AEX-1 is weakly similar to the rat protein Munc13, which regulates vesicle exocytosis; AEX-1 regulates UNC-13 localization; mutation of dgk-1, or a gain-of-function mutation of egl-30, suppresses the aex-1 mutant phenotype. D2030.2 D2030.2 Member of the ATPase family associated with various cellular activities, has moderate similarity to caseinolytic protease X (human CLPX), which may be involved in mitochondrial protein homeostasis and function as a tissue-specific mitochondrial chaperone ATP-dependent CLP protease (CLPX) like; This gene encodes a protein predicted by Eisenberg and coworkers, with 52% accuracy, to be mitochondrial. D2030.3 D2030.3 Protein of unknown function D2030.4 D2030.4 Protein with high similarity to human NDUFB7, which is a subunit of the NADH-ubiquinone oxidoreductase complex I and may function as a cell adhesion molecule and metastasis NADH:CoQ oxidoreductase subunit B18 D2030.5 D2030.5 Member of the glyoxalase, bleomycin resistance or dioxygenase superfamily, which are involved in the glyoxal pathway, has high similarity to uncharacterized methylmalonyl CoA epimerase (human MCEE) B.subtilis YQJC protein like D2030.6 prg-1;D2030.6 PIWI-related protein required for wild-type levels of germ-line proliferation D2030.7 D2030.7 Protein of unknown function Zinc finger, C3HC4 type (RING finger) D2030.8 D2030.8 Protein of unknown function D2030.9 D2030.9 Protein containing twelve WD domains (WD-40 repeat), which may mediate protein-protein interactions, has a region of low similarity to a region of human HPRP8BP, which is a U5 snRNP-specific protein that may function in mRNA splicing Lithosperm lec14B protein like D2045.1 atx-2;D2045.1 Proline- and glutamine-rich protein; weakly similar to human proteins containing CAG repeats (glutamine-rich); required for embryogenesis in C. elegans atx-2 is required for early embryonic patterning; it encodes an ortholog of human ataxin-2, which when mutated leads to spinocerebellar ataxia 2 (SCA2; OMIM:183090). D2045.2 D2045.2 Member of the cell wall biogenesis Ecm29p-like protein family D2045.5 D2045.5 Protein containing a protein kinase domain, has low similarity to casein kinase 1 alpha 1 (human CSNK1A1), which is a serine-threonine protein kinase that may be associated with Alzheimer's disease serine/threonine kinase D2045.6 cul-1;lin-19;D2045.6 Cell cycle control protein, member of the cullin family of cell cycle control proteins Cuticlin family; cul-1 encodes a cullin, orthologous to Cdc53/Cul1 in S. cerevisiae and CUL-1 in humans (OMIM:603134), that is required both maternally and zygotically for developmentally programmed transitions from the G1 phase of the cell cycle to the GO phase or the apoptotic pathway, and that is probably also required for normally slow G1-to-S phase progression; CUL-1 physically interacts with eight Skp1-related proteins (SKR-1, -2, -3, -4, -7, -8, -9, and -10). D2045.7 D2045.7 Serine/threonine protein kinase with similarity to human myristoylated and palmitoylated protein kinase MPSK1, has similarity to D. melanogaster cAMP-dependent protein kinase serine/threonine kinase D2045.8 D2045.8 Protein containing a K+ channel tetramerization domain, which facilitate assembly of alpha-subunits into functional tetrameric channels, has moderate similarity to uncharacterized C. elegans C40A11.6 TNF-alpha induced Protein B12 D2045.9 D2045.9 Member of the glycosyltransferase family 25 or LPS biosynthesis protein family, which are involved in lipopolysaccharide biosynthesis, has a region of moderate similarity to a region of cerebral cell adhesion molecule (human LOC51148) D2062.1 D2062.1 Protein of unknown function, has low similarity to a region of C. albicans Rbt4p, which is required for full virulence, is expressed specifically during hyphal growth, and is transcriptionally regulated by C. albicans Tup1p and C. albicans Efg1p D2062.2 D2062.2 Member of the 7-transmembrane chemoreceptor family of G protein-coupled receptors (GPCR), has moderate similarity to uncharacterized C. elegans Y27F2A.3 7TM chemoreceptor, sri family D2062.3 D2062.3 Member of the 7-transmembrane chemoreceptor family of G protein-coupled receptors (GPCR), has high similarity to uncharacterized C. elegans C14C6.10 7TM chemoreceptor, sri family D2062.4 D2062.4 Protein of unknown function, has high similarity to uncharacterized C. elegans D2062.5 D2062.5 D2062.5 Protein of unknown function, has high similarity to uncharacterized C. elegans D2062.4 D2062.6 D2062.6 Protein of unknown function, has high similarity to uncharacterized C. elegans F46F5.6 D2062.7 D2062.7 Protein of unknown function, has moderate similarity to C. elegans D2062.6 D2062.8 D2062.8 Member of the 7-transmembrane chemoreceptor family of G protein-coupled receptors (GPCR), has very strong similarity to uncharacterized C. elegans SRI-39 7TM chemoreceptor, sri family D2062.9 D2062.9 Member of the 7-transmembrane chemoreceptor family of G protein-coupled receptors (GPCR), has high similarity to uncharacterized C. elegans SRI-74 7TM chemoreceptor, sri family D2063.A D2063.3;D2063.A Protein of unknown function, has a region of moderate similarity to glutaredoxin (S. cerevisiae Grx4p), which is involved in the oxidative stress response D2063.B D2063.2;D2063.B Protein containing a DUF33 domain of unknown function, has high similarity to uncharacterized C. elegans K09E10.2 D2063.E D2063.1;D2063.E Member of the zinc-containing alcohol dehydrogenase family, which catalyze reversible oxidation of ethanol to acetaldehyde, has moderate similarity to alcohol dehydrogenase I (C. albicans Adh1p), which may function as an extracellular matrix adhesin D2085.1 D2085.1 Protein with high similarity to carbamoylphosphate synthetase 2-aspartate transcarbamylase-dihydroorotase (human CAD), which is involved in pyrimidine biosynthesis, member of the dihydroorotase-like and glutamine amidotransferase class I families glutamine-dependent carbamoyl-phosphate synthase, aspartate carbamoyltransferase, dihydroorotase; pyr-1 is orthologous to the human gene CARBAMYL PHOSPHATE SYNTHETASE I (CPS1, which when mutated leads to hyperammonemia (OMIM:237300); PYR-1 protein is predicted to be mitochondrial with 68% accuracy. D2085.2 D2085.2 Protein of unknown function, has weak similarity to C. elegans D2085.7 D2085.3 D2085.3 Protein containing 2 bacterial transferase hexapeptide domains and a eukaryotic translation initation factor W2 domain, has low similarity to translation initiation factor 2B subunit 5 (epsilon) (rat eIF-2Be), which is a guanyl-nucleotide exchange factor translation initiation factor (EIF); D2085.3 is orthologous to the human gene UNKNOWN (PROTEIN FOR MGC:9947) (EIF2B5; OMIM:603945), which when mutated leads to disease. D2085.4 D2085.4 Protein containing a HECT domain, which may confer ubiquitin-protein ligase activity, and an IQ calmodulin-binding domain, has a region of low similarity to a region of S. pombe Pub1p, which is a ubiquitin ligase similarity with a human hypothetical protein (PIR Acc. No. A38919) D2085.5 D2085.5 Protein of unknown function D2085.6 D2085.6 Protein with high similarity to GPI GlcNAc transferase a (mouse Piga), which is a subunit of the alpha 1 6 N acetylglucosaminyltransferase complex and acts in the biosynthesis of GPI anchors, member of the glycosyl transferases group 1 family phosphatidylinositol biosynthetic protein; D2085.6 is orthologous to the human gene CLASS A GLCNAC-INOSITOL PHOSPHOLIPID ASSEMBLY PROTEIN (PIGA; OMIM:311770), which when mutated leads to paroxysmal nocturnal hemoglobinuria. D2085.7 D2085.7 Protein of unknown function, has weak similarity to C. elegans D2085.2 D2089.1 D2089.1;Cep54;rsp-7 An SR protein, thought to be involved in mRNA splicing RNA binding protein D2089.2 D2089.2 Protein of unknown function, contains a short region with similarity to S. cerevisiae Ssm4p (involved in mRNA turnover) D2089.3 D2089.3 Protein of unknown function D2089.4 D2089.4;CePTB;ptb-1 Putative heterogeneous nuclear ribonucleoprotein (hnRNP), has strong similarity to human polypyrimidine tract binding protein (heterogeneous nuclear ribonucleoprotein I, PTB) and Drosophila SMOOTH (sm) (see BLAST); an SR-like protein polypyrimidine tract binding protein D2089.5 D2089.5 Protein with moderate similarity to gamma-butyrobetaine hydroxylase (rat Bbox), which catalyzes the conversion of gamma butyrobetaine to carnitine gamma-butyrobetaine,2-oxoglutarate dioxygenase; gbh-1 encodes a predicted ortholog of human hBBOX1; expressed in the intestine and in head and body muscles. D2092.1 D2092.1 Protein containing six C2 domains, which may be involved in calcium-dependent phospholipid binding C2 domain-containing protein D2092.2 D2092.2 Protein of unknown function D2092.3 acr-11;D2092.3 Protein with high similarity to C. elegans ACR-16, which is a nicotinic acetylcholine receptor alpha-1 subunit, contains neurotransmitter-gated ion-channel ligand binding and transmembrane domains ligand-gated ionic channel protein; A homolog of an alpha type nicotinic acetylcholine receptor subunit involved in the mediation of fast synaptic transmission at neuromuscular junctions. D2092.4 D2092.4 Protein of unknown function, has weak similarity to human PDIR, protein disulfide isomerase-related protein D2092.5 D2092.5 Protein of unknown function, has weak similarity to uncharacterized human FLJ10747 D2092.6 D2092.6 Protein of unknown function D2092.7 D2092.7 Member of the tetraspanin family, which contain an N-terminal transmembrane domain that is a signal sequence and membrane anchor transpanin D2092.8 D2092.8 Protein of unknown function D2096.1 D2096.1 Member of the mitochondrial import inner membrane translocase subunit Tim17, has a region of high similarity to a region of mitochondrial inner membrane translocase subunit 17b (human TIMM17B), which is involved in mitochondrial translocation D2096.10 D2096.10 Protein of unknown function, has moderate similarity to uncharacterized C. elegans F17E9.4 D2096.2 D2096.2 Protein with moderate similarity to glutamate transporter EAAC1-interacting protein (rat Gtrap3-18), which binds to the intracellular region of the excitatory glutamate carrier EAAC1 (Slc1a1) thus reducing the affinity for and transport of glutamate D2096.3 D2096.3 Member of the glycosyl hydrolases family 31, which are involved in carbohydrate metabolism, contains a P-type trefoil domain, has a region of moderate similarity to a region of maltase-glucoamylase (mucosal glucoamylase, human MGAM), which digests starch D2096.4 D2096.4 Member of the NAD-dependent epimerase or dehydratase family, which catalyze reactions involving nucleotide sugar substrates, has a region of high similarity to UDP-glucuronate decarboxylase (C. neoformans Uxs1_D) sqv-1 encodes a UDP-glucuronic acid decarboxylase, biochemically active in vitro, that is required for cytokinesis of one-cell embryos and for vulval morphogenesis; SQV-1 is coexpressed with the nucleotide-sugar transporter homolog SQV-7 in in the vulva and in oocytes; SQV-1 colocalizes with SQV-5 and SQV-7 to punctate foci (probably the Golgi apparatus) in the cytoplasm of the vulva, the uterus and oocytes, within which SQV-1 may act to promote the biosynthesis of chondroitin glycosaminoglycans; the common requirement for SQV-1 in both cytokinesis and morphogenesis may be to promote filling an extracellular space with hygroscopic proteoglycans (either in the eggshell, or underneath the L4 cuticle), which in turn may cause the space to fill with fluid. D2096.5 D2096.5 Protein of unknown function, has weak similarity to C. elegans T26A8.3 D2096.6 myo2-D;D2096.6 Protein of unknown function, has high similarity to uncharacterized C. elegans T25E4.1 D2096.7 D2096.7 Protein of unknown function D2096.8 D2096.8 Member of the nucleosome assembly protein (NAP) family, has moderate similarity to nucleosome assembly protein 1-like 4 (human NAP1L4), which is a histone chaperone that acts in the transfer of core and linker histones to DNA and in nucleosome assembly D2096.9 D2096.9 Protein with moderate similarity to C. elegans K09C6.3 gene product DC2.1 DC2.1 Protein of unknown function, putative paralog of C. elegans W03F9.6, C04F2.1, and F09G2.7 7TM chemoreceptor, srh family DC2.2 DC2.2 Protein of unknown function, putative paralog of C. elegans C04F2.1 and W03F9.6 7TM chemoreceptor, srh family DC2.3 DC2.3 DC2.3 Protein with similarity over the C-terminus to human and C. elegans galactoside-binding lectins galactoside-binding lectin DC2.4 DC2.4 Protein of unknown function DC2.5 DC2.5 Protein with similarity to alcohol and other short chain dehydrogenases, putative paralog of C. elegans E04F6.7 dehydrogenase; This gene encodes a protein predicted by Eisenberg and coworkers, with 52% accuracy, to be mitochondrial. DC2.6 DC2.6 Protein of unknown function, putative paralog of C. elegans C04F2.1 and W03F9.6 7TM chemoreceptor, srh family DC2.7 DC2.7 Protein containing a putative eukaryotic protein kinase domain protein kinase DH11.1 DH11.1 Member of the ank repeat protein family glutaminase DH11.2 DH11.2 Protein of unknown function DH11.3 DH11.3 Member of the ABC transporter family, contains two ABC transporter transmembrane domains, has low similarity to C. elegans PGP-3, which is a P-glycoprotein of intestinal cells that acts as a multidrug resistance protein multidrug resistance protein; pgp-11 encodes a transmembrane protein that is a member of the P-glycoprotein subclass of the ATP-binding cassette (ABC) transporter superfamily; by homology, PGP-11 is predicted to function as an ATP-dependent efflux pump that protects C. elegans by exporting exogenous toxins; however, as loss of pgp-11 activity via large-scale RNAi screens does not result in any obvious abnormalities, the precise role of PGP-11 in C. elegans development and/or behavior is not yet known. DH11.4 DH11.4 Protein with weak similarity to C. elegans C08G5.4 gene product synaptotagamin carboxyl terminus DH11.5 DH11.5 Protein of unknown function DUR91 dur91 Dauer-upregulated protein 191 DY3.1 DY3.1 Protein containing a Tim10 or DDP family zinc finger domain, has a region of high similarity to translocase of the mitochondrial inner membrane 13 (human TIMM13A), which is a mitochondrial translocase subunit DY3.2 lmn-1;lam-1;DY3.2 Nuclear type-B lamin ortholog; required for normal cell cycle progression and chromatin organization Intermediate filament proteins (2 domains); The lmn-1 gene encodes a nuclear lamin; LMN-1 protein is essential for the nuclear envelope localization of emerin (EMR-1) protein during during early development. DY3.3 DY3.3 Protein containing one helix-loop-helix DNA-binding domain, which mediate protein dimerization Helix-loop-helix DNA-binding domain DY3.4 CeTERT;DY3.4 Member of the reverse transcriptase family, which are RNA-dependent DNA polymerases Reverse transcriptase (RNA-dependent DNA polymerase); trt-1 encodes C. elegans telomerase reverse transcriptase that affects fertility, maintenance of telomere length, and chromosome nondisjunction. DY3.5 DY3.5 Protein of unknown function, contains a coiled-coil region, has weak similarity to C. elegans ZC334.5, has weak similarity over the C-terminus to human REST (RE1-silencing transcription factor) The protein product of this gene is predicted to contain a glutamine/asparagine (Q/N)-rich ('prion') domain, by the algorithm of Michelitsch and Weissman (as of the WS77 release of WormBase, i.e., in wormpep77). DY3.6 DY3.6 Protein containing an F-box domain, which serve as a link between a target protein and a ubiquitin-conjugating enzyme, has low similarity to uncharacterized f-box only protein 32 (human FBXO32) This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins. DY3.7 sup-17;DY3.7 Transmembrane disintegrin/metalloprotease of the ADAM family Zinc-binding metalloprotease domain; sup-17 encodes an ADAM protein, an integral membrane disintegrin and zinc-activated metalloproteinase, orthologous to Drosophila and mouse KUZBANIAN and the vertebrate ADAM10 proteins; SUP-17 is required maternally for embryonic development and plays a role in LIN-12/Notch-mediated cell signaling required for several cell fate decisions during vulval development; SUP-17 is also required for normal body morphology and male tail development; SUP-17 functions cell autonomously to facilitate LIN-12 signaling and requires the LIN-12 extracellular domain to do so. E01A2.1 E01A2.1 Protein with moderate similarity to H. sapiens GLCLR (glutamate-cysteine ligase (gamma-glutamylcysteine synthetase), regulatory (30.8kD)) E01A2.2 E01A2.2 Putative ortholog of D. melanogaster CG7843 (CG7843 gene product) E01A2.4 E01A2.4 Protein with moderate similarity to D. melanogaster CG6066 (CG6066 gene product) E01A2.5 E01A2.5 Protein with strong similarity to D. melanogaster CG1578 (CG1578 gene product) E01A2.6 E01A2.6 Protein with weak similarity to D. melanogaster CG8580 (CG8580 gene product) E01A2.7 E01A2.7 Putative paralog of C. elegans E01A2.8 The E01A2.7 gene encodes one of five paraoxonase-like proteins; it is homologous to the human genes PARAOXONASE 1 gene (PON1, OMIM:168820) and PARAOXONASE 2 (OMIM:602447), which in some allelic forms are associated with susceptibility to coronary artery disease or to variations in fasting plasma glucose. E01A2.8 E01A2.8 Putative paralog of C. elegans E01A2.7 The E01A2.8 gene encodes one of five paraoxonase-like proteins; it is homologous to the human PARAOXONASE 1 gene (PON1, OMIM:168820), which in some allelic forms is associated with susceptibility to coronary artery disease. E01A2.G lin-44;E01A2.3;E01A2.G Protein with strong similarity to H. sapiens WNT2 gene product E01B7.1 E01B7.1 Protein of unknown function, has low similarity to a region of ubiquitin specific protease 8 (human USP8), which is a deubiquitinating enzyme that plays a role in proliferation and cell cycle control E01B7.2 E01B7.2 Protein of unknown function, putative paralog of C. elegans C06H5.4 E01F3.1 E01F3.1 Member of the 3',5'-cyclic nucleotide phosphodiesterase family, has moderate similarity to a region of cGMP inhibited phosphodiesterase 3A (human PDE3A), which hydrolyzes cAMP to AMP and may be associated with obesity and diabetes mellitus type II 3'5'-cyclic nucleotide phosphodiesterases E01G4.1 E01G4.1 Protein with weak similarity over C-terminal half to S. cerevisiae GTPase-activating protein, GYP7; contains a coiled-coil region E01G4.2 E01G4.2 Protein containing a MIF4G (middle domain of eukaryotic initiation factor 4G) domain E01G4.3 E01G4.3 Protein of unknown function E01G4.4 E01G4.4 Protein of unknown function The protein product of this gene is predicted to contain a glutamine/asparagine (Q/N)-rich ('prion') domain, by the algorithm of Michelitsch and Weissman (as of the WS77 release of WormBase, i.e., in wormpep77). E01G4.5 E01G4.5 Putative ortholog of C. elegans Y116F11.Y gene product E01G4.6 E01G4.6 Putative coiled-coil protein, has weak similarity to myosin heavy chains E01G6.1 E01G6.1 Protein containing three kunitz or bovine pancreatic trypsin inhibitor domains and an EB module domain, has a region of low similarity to tissue factor pathway inhibitor (human TFPI), which is a protease inhibitor that prevents fibrin clot formation pancreatic trypsin inhibitor (kunitz) protein E01G6.2 E01G6.2 Protein of unknown function E01G6.3 E01G6.3 Protein with strong similarity to esterases, putative paralog of C. elegans C23H4.2 serine esterase E01H11.1 kin-11;pkc-2;PKC2;E01H11.1 Serine/threonine protein kinase with strong similarity to human, D. melanogaster, and S. cerevisiae protein kinase C isoforms Protein kinase C; pkc-2 is orthologous to the human gene PROTEIN KINASE C ALPHA (AA 1-672) (PRKCA; OMIM:176960), which when mutated leads to disease. E01H11.2 E01H11.2 Protein of unknown function E01H11.3 E01H11.3 Protein of unknown function flp-20 encodes two copies of a single FMRFamide-related short peptide neurotransmitter; the precise role of this peptide in C. elegans neurotransmission is not yet known. E02A10.1 E02A10.1 Member of the ribosomal S5 protein family mitochondrial 40S ribosomal protein S5; This gene encodes a protein predicted by Eisenberg and coworkers, with 68% accuracy, to be mitochondrial. E02A10.2 E02A10.2 Putative coiled-coil protein, has similarity in the C-terminus to the coiled-coil domain of human GOLGA4 (golgi autoantigen, golgin subfamily) E02A10.3 E02A10.3 Protein containing four EF hand domains, has moderate similarity to calmodulin 1 (phosphorylase kinase, delta, rat Calm1), which is a neuronal cell protein that binds calcium calmodulin-like protein E02C12.10 E02C12.10 Protein containing a DUF227 domain of unknown function E02C12.11 E02C12.11 Protein with strong similarity to C. elegans E02C12.10 gene product E02C12.12 E02C12.12 Putative ortholog of C. elegans E02C12.10 gene product E02C12.2 E02C12.2 Protein of unknown function, has high similarity to uncharacterized C. elegans E02C12.3, which is predicted to be a G protein-coupled receptor 7TM chemoreceptor, srx family E02C12.3 E02C12.3 Protein of unknown function, has high similarity to uncharacterized C. elegans E02C12.2, which is predicted to be a G protein-coupled receptor 7TM chemoreceptor, srx family E02C12.4 E02C12.4 Member of the transthyretin-like family, has low similarity to uncharacterized C. elegans F22A3.2 E02C12.5 gpa-3;gba-3;E02C12.5 Member of the G protein alpha subunit family guanine nucleotide-binding protein; gpa-3 encodes a member of the G protein alpha subunit family of heterotrimeric GTPases that affects dauer formation, water-soluble chemoattraction and chemoaversion, and volatile chemoattraction; it is expressed in amphid and phasmid neurons and some interneurons. E02C12.6 E02C12.6 Protein containing a DUF227 domain of unknown function, has high similarity to uncharacterized C. elegans Y45G12C.4 E02C12.7 E02C12.7 Protein containing a DUF227 domain of unknown function, has high similarity to uncharacterized C. elegans E02C12.9 E02C12.8 E02C12.8 Protein of unknown function, has strong similarity to C. elegans E02C12.10 E02C12.9 E02C12.9 Protein containing a DUF227 domain of unknown function, has high similarity to uncharacterized C. elegans E02C12.7 E02D9.1 E02D9.1 Protein containing two protein kinase domains, has a region of low similarity to a region of MAP kinase kinase 5 (mouse Map2k5), which may participate in mitogenic signaling pathways and is a positive modulator of cell proliferation protein kinase E02D9.2 E02D9.2 Protein of unknown function E02H1.1 E02H1.1 Protein with high similarity to dimethyladenosine transferase (rRNA (adenine-N6,N6-)-dimethyltransferase, S. cerevisiae Dim1p), which is responsible for dimethylation of 18S rRNA 3'-terminal loop, member of the ribosomal RNA adenine dimethylases family rRNA methyltransferase E02H1.2 E02H1.2 Protein of unknown function, has low similarity to uncharacterized Era-like 1 (mouse Eral1), which is a putative GTPase with possible roles in cell cycle control GTP binding protein; This gene encodes a protein predicted by Eisenberg and coworkers, with 68% accuracy, to be mitochondrial. E02H1.3 E02H1.3 Member of the tRNA pseudouridine synthase family, has low similarity to S. cerevisiae Deg1p, which is a pseudouridine synthase that catalyzes the formation of pseudouridine-38 and -39 in cytoplasmic and mitochondrial tRNAs Yeast DEG-1 protein homolog; This gene encodes a protein predicted by Eisenberg and coworkers, with 68% accuracy, to be mitochondrial. E02H1.4 E02H1.4 Protein containing a poly(ADP-ribose) polymerase catalytic domain and a poly(ADP-ribose) polymerase regulatory domain, has low similarity to poly (ADP ribose) polymerase 2 (mouse Adprt2), which binds to damaged DNA and is involved in genome protection ADP-Ribosyltransferase E02H1.5 E02H1.5 Protein of unknown function, has low similarity to uncharacterized human LOC51637 E02H1.6 E02H1.6 Protein with high similarity to S. cerevisiae Fap7p, which is an essential protein important for Skn7p-dependent transcription of target genes during oxidative stress ATP binding protein E02H1.7 nhr-19;E02H1.7 Protein containing two nuclear hormone receptor C4-type zinc finger domains and two nuclear hormone receptor ligand-binding domains, has low similarity to hepatocyte nuclear factor 4 gamma (human HNF4G), which is involved in transcriptional regulation Zinc finger, C4 type (two domains) E02H4.1 del-1;E02H4.1 Member of the amiloride-sensitive sodium channel family, has similarity to H. sapiens and D. melanogaster amiloride-sensitive cation channels mechanosensory protein; del-1 encodes an ion channel protein of the DEG/ENaC (degenerin/epithelial Na+ channel) family; like other members of the degenerin family, DEL-1 is predicted to function as a sensory mechanotransduction channel, however detailed analysis of the DEL-1 mutant phenotype has not yet been reported; DEL-1 is expressed postembryonically in the VA and VB motor neurons and in the FLP sensory neurons; the DEL-1 expression pattern overlaps that of UNC-8, an additional C. elegans degenerin involved in movement control, with which DEL-1 may coassemble to form mechanically activated cation channels. E02H4.2 E02H4.2 Protein of unknown function E02H4.3 E02H4.3 Protein containing a protein kinase domain, has a region of high similarity to CDC-like kinase 2 (human CLK2), which is a dual specificity protein kinase that associates with serine- and arginine-rich (SR) proteins and may thus regulate mRNA splicing serine/threonine kinase (CLK subfamily) E02H4.4 E02H4.4 Putative ortholog of C. elegans K06G5.1 gene product E02H4.5 E02H4.5 Protein of unknown function E02H4.6 E02H4.6 Protein containing a protein kinase domain, has high similarity to uncharacterized C. elegans K04C1.5 serine/threonine kinase E02H9.1 E02H9.1 Protein with moderate similarity to C. elegans E02H9.9 gene product E02H9.2 E02H9.2 Protein with strong similarity to C. elegans C49A9.4 gene product E02H9.3 E02H9.3 Putative ortholog of C. elegans C49A9.9 gene product E02H9.4 E02H9.4 Protein of unknown function, has moderate similarity to C. elegans C49A9.1 E02H9.5 E02H9.5 Member of the glycosyl hydrolases family 1, which may be involved in carbohydrate metabolism, has moderate similarity to a region of lactase-phlorizin hydrolase (human LCT), which is a lactase and phloridzin hydrolase associated with adult hypolactasia glycosyl hydrolase; E02H9.5 is orthologous to the human gene LPH PREPRO-POLYPEPTIDE (AA -19 TO 1908) (LCT; OMIM:603202), which when mutated leads to disease. E02H9.6 E02H9.6 Putative ortholog of C. elegans W04B5.6 gene product E02H9.7 E02H9.7 Protein of unknown function, has weak similarity to C. elegans E02H9.2 E02H9.8 E02H9.8 Protein containing nuclear hormone receptor C4-type zinc finger and ligand-binding domains, has low similarity to C. elegans NHR-80, which is involved in embryogenesis and morphogenesis E02H9.9 E02H9.9 Protein with moderate similarity to C. elegans E02H9.1 gene product E03A3.2 E03A3.2 Member of the RECQ family of helicases DNA helicase E03A3.3 E03A3.3 Protein with strong similarity to H3 histone family 3A (mouse H3f3a), which is expressed independently of DNA replication and is required for normal growth rates and male fertility, member of the histone family of nucleosomal core proteins histone H3; his-69 encodes a truncated H3 histone. E03A3.4 E03A3.4 Protein with high similarity to H3 histone family 3A (mouse H3f3a), which is expressed independently of DNA replication and is required for normal growth rates and male fertility, member of the histone family of nucleosomal core proteins histone H3; his-70 encodes an H3 histone. E03A3.5 E03A3.5 Protein containing two CUB domains, has a region of low similarity to a region of cubilin (intrinsic factor-cobalamin receptor, rat Cubn), which is a receptor for vitamin B12 and intrinsic factor and plays a role in receptor mediated endocytosis disulphide bond domain E03A3.6 E03A3.6 Protein of unknown function A novel protein involved in responsiveness to volatile anesthetics; it is expressed primarily in the nervous system. E03A3.7 E03A3.7 Protein of unknown function E03A3.8 C03C10.7;E03A3.8 Protein of unknown function E03D2.1 E03D2.1 MSFamide neurotransmitter neuropeptide; nlp-13 encodes a predicted neuropeptide of the MSFamide family; expressed primarily in neurons or in the endocrine/secretory cells, and expression includes pharyngeal neurons that modulate pharyngeal pumping of food. E03D2.2 E03D2.2 GGARAF neurotrasmitter E03D2.3 E03D2.3 Member of the 7-transmembrane chemoreceptor family of G protein-coupled receptors (GPCR), has high similarity to uncharacterized C. elegans Y68A4A.1 7TM chemoreceptor, srh family E03D2.4 E03D2.4 Protein containing a DUF32 domain of unknown function, has high similarity to uncharacterized C. elegans ZC142.1 7TM chemoreceptor, srt family E03E2.1 E03E2.1 Member of the cytochrome P450 family, has low similarity to cytochrome P450 subfamily 3A polypeptide 43 (human CYP3A43), which has low testosterone hydroxylase activity cytochrome P450 E03G2.1 E03G2.1 Protein with moderate similarity to C. elegans F31B9.3 gene product E03G2.2 E03G2.2 Member of the ABC transporter family, contains two ABC transporter transmembrane domains, has moderate similarity to ATP-binding cassette subfamily C member 1a (mouse Abcc1a), which is an ATP-binding cassette transporter multidrug resistance-associated protein E03G2.3 mec-5;E03G2.3 Collagen of the collagen triple helix repeat (20 Copies) protein family collagen-like repeats; mec-5 encodes a collagen unique in the number of Gly-X-Y repeats and in the composition of amino acids surrounding these repeats; MEC-5 is required for normal mechanosensory response to gentle touch and for the proper functioning of the touch receptor neurons; mec-5 interacts genetically with mec-4 and mec-10 which encode degenerins (ion channels) expressed in the touch neurons, mec-9, which encodes a protein containing EGF-like and Kunitz/protease inhibitor domains secreted by the touch neurons, and mec-12, which encodes an alpha-tubulin expressed in the touch neurons; these genetic interactions suggest that MEC-5 may play a role in anchoring the degenerin complex to the extracellular matrix; MEC-5 is produced and secreted by hypodermal cells. E03G2.4 E03G2.4 Protein containing two collagen triple helix repeats, which are found in some extracellular proteins, and a nematode cuticle collagen N-terminal domain, has a region of high similarity to a region of C. elegans LET-2, which is a type IV collagen cuticle collagen E03H12.1 E03H12.1 Member of the 7-transmembrane chemoreceptor family of G protein-coupled receptors (GPCR), has low similarity to C. elegans ODR-10, which is involved in odorant response 7TM chemoreceptor, str family E03H12.10 ssp-9;E03H12.10 Protein containing a major sperm protein (MSP) domain, which are involved in sperm motility, has strong similarity to uncharacterized C. elegans SSP-11 E03H12.2 E03H12.2 Protein with similarity to members of the C-type lectin family E03H12.3 E03H12.3 Protein of unknown function, has high similarity to uncharacterized C. elegans E03H12.2 E03H12.4 E03H12.4 Putative ortholog of C. elegans E03H12.3 gene product E03H12.5 E03H12.5 Protein with weak similarity to C. elegans Y113G7B.12 gene product E03H12.6 E03H12.6 Protein containing a DUF216 domain of unknown function, has moderate similarity to uncharacterized C. elegans C08F11.9 7TM chemoreceptor, srz family E03H12.7 E03H12.7 Protein of unknown function, has strong similarity to C. elegans T08H10.3 E03H12.9 E03H12.9 Protein of unknown function, has moderate similarity to C. elegans E03H12.2 E03H4.1 E03H4.1 Member of the transposase family, which are required for excising and inserting mobile genetic elements, has very strong similarity to uncharacterized C. elegans C10H11.2 transposase E03H4.10 E03H4.10 Member of the C-type lectin family, has similarity to human C-type mannose receptor MRC1, has similarity to D. melanogaster TOLLOID and TOLKIN proteins C-type lectin domain E03H4.11 E03H4.11 Member of the galactosyltransferase family, has a region of low similarity to UDP-galactose:beta-N-acetylglucosamine beta-1,3-galactosyltransferase (human B3GALT1), which requires beta-linked GlcNAc acceptors and is decreased in some colon adenocarcinomas E03H4.12 E03H4.12 Protein of unknown function, has moderate similarity to a region of glucuronyl transferase-I (GlcAT-I) (C. elegans SQV-8), which is involved in proteoglycan biosynthesis and is important for vulval invagination E03H4.13 nhr-89;E03H4.13 Member of the zinc finger protein family with similarity to nuclear hormone receptors, may be involved in epidermal fate specification Zinc finger, C4 type (two domains) E03H4.2 E03H4.2 Member of the domain of unknown function DUF13 family, has high similarity to uncharacterized C. elegans ZK1025.3 E03H4.3 E03H4.3 Member of the galactosyltransferase family, which transfer galactose to GlcNAc termini of growing oligosaccharide chains, has high similarity to uncharacterized C. elegans F56H6.1 E03H4.4 E03H4.4 Member of an uncharacterized protein family E03H4.5 E03H4.5 Protein of unknown function, has strong similarity to uncharacterized C. elegans T15D6.12 E03H4.6 nhr-B;E03H4.6 Protein containing nuclear hormone receptor C4-type and ligand-binding zinc finger domains, has a region of low similarity to a region of the glucocorticoid receptor (mouse Nr3c1), which is a transcription factor that functions in inflammation Zinc finger, C4 type (two domains) E03H4.7 E03H4.7 Protein containing a DUF33 domain of unknown function, has high similarity to uncharacterized C. elegans F14B6.5 E03H4.8 E03H4.8 Protein of unknown function, has high similarity to a region of coatomer protein (COP) complex subunit beta 2 (COP beta prime, mouse Copb2), which is part of a Golgi coatomer complex that comprises the coat of non-clathrin coated vesicles beta' coatomer protein like E04A4.1 E04A4.1 Protein containing an F-box domain, which serve as a link between a target protein and a ubiquitin-conjugating enzyme, has moderate similarity to uncharacterized C. elegans Y17G9B.7 This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins; its encoded protein also contains a Pfam-B45 motif of presently unknown function. E04A4.2 E04A4.2 Protein of unknown function, has moderate similarity to C. elegans M116.4 E04A4.3 E04A4.3 Protein of unknown function, has moderate similarity to uncharacterized C. elegans F25G6.1 E04A4.4 E04A4.4 Member of the metallo-beta-lactamase family, has low similarity to uncharacterized human ELAC2 hoe-1 is orthologous to human ELAC2 (OMIM:605367, associated with susceptibility to prostate cancer); hoe-1 is required for normally rapid growth and normally short body length in mass RNAi assays. E04A4.5 E04A4.5 Protein with high similarity to mitochondrial inner membrane translocase subunit 17b (human TIMM17B), which is involved in mitochondrial translocation, member of the mitochondrial import inner membrane translocase subunit Tim17 family E04A4.6 E04A4.6 Protein of unknown function E04A4.7 E04A4.7 Protein with high similarity to somatic cytochrome c (mouse Cycs), which is involved in mitochondrial respiration, contains a cytochrome c family heme-binding site domain cytochrome C; This gene encodes a protein predicted by Eisenberg and coworkers, with 52% accuracy, to be mitochondrial. E04A4.8 E04A4.8 Protein with high similarity to ribosomal protein L20 (S. cerevisiae Rpl20ap), which is a structural ribosomal protein, member of the ribosomal L18ae family, which form part of the large ribosomal subunit ribosomal protein; rpl-20 encodes a large ribosomal subunit L18a protein. E04D5.1 E04D5.1 Putative ortholog of S. cerevisiae Ygr054p, a protein of unknown function E04D5.2 E04D5.2 Protein of unknown function, has low similarity to uncharacterized C. elegans C54D10.5 E04D5.3 E04D5.3 Protein with strong similarity to C. elegans cut-1 (Cuticulin component) cuticlin like protein E04D5.4 E04D5.4 Protein of unknown function, has high similarity to uncharacterized C. elegans ZK673.1 E04F6.1 E04F6.1 Protein of unknown function, has strong similarity to uncharacterized C. elegans E04F6.13 7TM chemoreceptor, srd family E04F6.10 E04F6.10 Protein of unknown function E04F6.11 clc-3;clh-3;E04F6.11 Chloride channel protein, putative ortholog of H. sapiens CLCN1 gene product (chloride channel 1) Chloride channel protein; The clh-3 gene encodes a chloride channel homologous to the mammalian channel ClC-2. E04F6.12 E04F6.12 Protein of unknown function E04F6.13 E04F6.13 Protein with similarity to the C. elegans srd family of 7TM receptors 7TM chemoreceptor, srd family E04F6.14 E04F6.14 Protein with similarity to the C. elegans srd family of 7TM receptors 7TM chemoreceptor, srd family E04F6.15 E04F6.15 Putative ortholog of C. elegans DC2.5 gene product E04F6.2 E04F6.2 Protein of unknown function E04F6.3 E04F6.3 Protein containing a MaoC-like dehydratase domain, has high similarity to a region of type IV 17 beta-hydroxysteroid dehydrogenase (mouse Hsd17b4), which is a peroxisomal multifunctional enzyme with dehydrogenase and dehydratase activities Hydratase-dehydrogenase-epimerase; E04F6.3 encodes a protein that is orthologous (with 52% identity over 93% of its length) to residues 334-609 of human 17-BETA-HYDROXYSTEROID DEHYDROGENASE IV (HSD17B4; OMIM:601860, mutated in D-bifunctional protein deficiency), a protein of 736 residues whose N- and C-terminal domains are orthologous to DHS-28; E04F6.3 contains a MaoC-like domain, found in diverse enzymes (HSD17B4, peroxisomal hydratase-dehydrogenase-epimerase, and the fatty acid synthase beta subunit); E04F6.3 has no obvious function in mass RNAi assays. E04F6.4 E04F6.4 Protein containing two phospholipase D active site motifs V. virus protein K4 E04F6.5 E04F6.5 Protein with high similarity to rat Acadvl, which is a very-long-chain acyl-coenzyme A dehydrogenase, contains an acyl-CoA dehydrogenase N-terminal domain, an acyl-CoA dehydrogenase middle domain, and an acyl-CoA dehydrogenase C-terminal domain Isovaleryl-CoA dehydrogenase; E04F6.5 is orthologous to the human gene ACYL-CoA DEHYDROGENASE, VERY LONG-CHAIN (OMIM:201475), which when mutated leads to VLCAD deficiency, an inborn error of mitochondrial beta-oxidation. E04F6.6 E04F6.6 Protein of unknown function, has strong similarity to C. elegans C50D2.1 E04F6.7 E04F6.7 Member of the short-chain dehydrogenase-reductase family, which are NAD- or NADP-dependent oxidoreductases, has moderate similarity to WW domain-containing oxidoreductase (mouse Wwox), which is an apoptosis activator induced by hyaluronidase Ribitol dehydrogenase; dhs-7 encodes a short-chain dehydrogenase predicted to be mitochondrial. E04F6.8 E04F6.8 Protein of unknown function, has high similarity to uncharacterized C. elegans E04F6.9 E04F6.9 E04F6.9 Protein of unknown function, has moderate similarity to C. elegans E04F6.8 EEED8.1 EEED8.1;2F713 Protein containing two tudor domains, which are found in proteins involved in RNA localization EEED8.10 EEED8.10 Protein containing an RNA recognition motif (RRM, RBD, or RNP), has a region of weak similarity to F box leucine rich repeat 3 (human FBXL2), which is a putative subunit of the SCF ubiquitin ligase involved in protein degradation Probable RNA binding protein.; This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins. EEED8.11 EEED8.11 Protein of unknown function, has moderate similarity to uncharacterized C. elegans C04H5.2 EEED8.12 EEED8.12 Protein containing an RNA recognition motif (RRM, RBD, or RNP), has a region of moderate similarity to a region of poly(A)-binding protein (nuclear 1, human PABPN1), which stimulates long poly(A) tail synthesis and may play a role in nuclear mRNA export Probable RNA binding protein EEED8.13 EEED8.13 Protein of unknown function EEED8.14 EEED8.14 Putative coiled-coil protein EEED8.15 EEED8.15 Protein of unknown function EEED8.16 EEED8.16 Protein with weak similarity to C. elegans Y4C6B.A gene product EEED8.2 EEED8.2 Protein of unknown function EEED8.3 EEED8.3 Protein of unknown function EEED8.4 EEED8.4 Protein containing an RNA recognition motif (RRM, RBD, or RNP), has a region of moderate similarity to a region of poly(A)-binding protein (nuclear 1, human PABPN1), which stimulates long poly(A) tail synthesis and may play a role in nuclear mRNA export Probable RNA binding protein EEED8.5 mog-5;EEED8.5;CeHRH1 Member of the RNA helicase, DEAH-box protein family; an SR-like protein RNA helicase; The mog-5 gene encodes a DEAH helicase orthologous to the Drosophila CG8241, the human HRH1, and the S. cerevisiae PRP22 proteins. EEED8.6 EEED8.6 Protein with strong similarity to C. elegans F56H1.5 gene product EEED8.7 rsp-4;srp-2;CeSC35;EEED8.7 SR protein involved in mRNA splicing splicing factor SC35 EEED8.8 EEED8.8 Member of the bacterial mutT protein family The ndx-6 gene encodes a NUDIX hydrolase. EEED8.9 EEED8.9 Protein containing two protein kinase domains, has a region of low similarity to a region of S. cerevisiae Rad53p, which is a serine-threonine-tyrosine protein kinase with a checkpoint function in the S and G2 phases of the cell cycle EGAP1.1 EGAP1.1 Protein of unknown function EGAP2.1 EGAP2.1 Protein of unknown function EGAP2.2 EGAP2.2 Protein of unknown function EGAP2.3 EGAP2.3 Member of the histidine acid phosphatase family, which hydrolyze phosphate esters at low pH, has low similarity to human ACPP, which is a prostatic acid phosphatase that dephosphorylates the oncoprotein human ERBB2 and negatively regulates cell growth pho-1 encodes the major C. elegans intestinal acid phosphatase; as loss of PHO-1 function via RNA-mediated interference (RNAi) does not result in any abnormalities, PHO-1 may function redundantly with other acid phosphatases; PHO-1 intestinal expression appears to be positively regulated by CKI-1, a cyclin-dependent kinase inhibitor, and negatively regulated by POP-1, a TCF/LEF transcription factor; PHO-1 is expressed along the intestinal brush border in all gut cells except the most anterior int-1 and int-2 cells, beginning at the three-fold stage of embryogenesis. EGAP4.1 EGAP4.1 Protein of unknown function, has weak similarity to C. elegans F59D6.1 transposase EGAP5.1 EGAP5.1 Protein with strong similarity to C. elegans EGSP.1 gene product EGAP7.1 EGAP7.1 Protein containing two collagen triple helix repeats, which are found in some extracellular proteins, and a nematode cuticle collagen N-terminal domain, has a region of high similarity to a region of collagen type IX alpha 3 (human COL9A3) cuticular collagen EGAP798.A EGAP798.1;EGAP798.A Putative ortholog of C. elegans W09B7.D gene product EGAP9.2 EGAP9.2 Member of the glycosyl transferase family 11, which hydrolyze the glycosidic bond between two or more carbohydrates, has high similarity to uncharacterized C. elegans EGAP9.3 EGAP9.3 EGAP9.3 Member of the glycosyl transferase family 11, which hydrolyze the glycosidic bond between two or more carbohydrates, has high similarity to uncharacterized C. elegans EGAP9.2 F01D4.1 F01D4.1 Protein containing a UDP-glucoronosyl and UDP-glucosyl transferase domain, has low similarity to olfactory UDP-glucuronosyltransferase (human UGT2A1), which catalyzes the glucuronidation of substrates such as odorants, steroids, drugs, and carcinogens UDP-glucoronosyltransferase F01D4.2 F01D4.2 Protein containing two UDP-glucoronosyl and UDP-glucosyl transferase domains, has low similarity to UDP-glucuronosyltransferase 8 (UDP-galactose ceramide galactosyltransferase, rat Ugt8), which acts in the biosynthesis of galactosylceramide UDP-glucoronosyltransferase F01D4.3 F01D4.3 Protein containing a protein kinase domain and a Src homology 2 (SH2) domain, has moderate similarity to fer (fps/fes related) tyrosine kinase (mouse Fert2), which may mediate cell-cell signaling and cell size-dependent cytoskeletal reorganization tyrosine-protein kinase (FES/FPS subfamily) F01D4.4 F01D4.4 Member of the carboxypeptidase A metalloprotease (M14) family of zinc carboxypeptidases, has moderate similarity to carboxypeptidase E (human CPE), which is a metalloprotease involved in the processing of peptide hormones and neurotransmitters zinc carboxypeptidase; Uncloned locus that affects egg laying. F01D4.5 F01D4.5 Protein of unknown function F01D4.6 mec-3;F01D4.6 LIM homeodomain transcription factor required for expression of mec-4 and mec-7 and required for touch receptor cell differentiation, has similarity to human LIM-1 and D. melanogaster LIM3 LIM homeodomain transcription factors LIM domain containing proteins (2 domains), homeobox protein (lim subfamily) F01D4.7 F01D4.7 G protein-coupled receptor; member of a subfamily with SRB proteins, which are expressed in chemosensory neurons; no homolog found in human or D. melanogaster 7TM receptor, srb family F01D4.8 F01D4.8 Member of the pyridoxal phosphate dependent enzyme beta family, has high similarity to uncharacterized C. elegans F13B12.4 cysteine synthase like F01D5.1 F01D5.1 Protein containing a DUF18 domain of unknown function, has high similarity to uncharacterized C. elegans Y39G8B.7 F01D5.10 F01D5.10 Protein of unknown function, has high similarity to uncharacterized C. elegans F25E5.2 F01D5.11 F01D5.11 Protein containing a DUF38 domain of unknown function F01D5.2 F01D5.2 Protein of unknown function, has high similarity to uncharacterized C. elegans F01D5.3 F01D5.3 F01D5.3 Protein of unknown function, has high similarity to uncharacterized C. elegans F01D5.2 F01D5.5 F01D5.5 Protein of unknown function, has strong similarity to C. elegans F01D5.1 F01D5.6 F01D5.6 Protein of unknown function, has weak similarity to C. elegans Y12A6A.1 F01D5.7 F01D5.7 Protein of unknown function, has high similarity to uncharacterized C. elegans F01D5.8 F01D5.8 F01D5.8 Member of the phospholipase and carboxylesterase family, which have broad substrate specificity, has moderate similarity to uncharacterized human LOC51104 F01D5.9 F01D5.9 Member of the cytochrome P450 family, has moderate similarity to cytochrome P450 subfamily 4F polypeptide 2 (human CYP4F2), which is an arachidonic acid- and leukotriene B4 omega-hydroxylase that regulates salt and water homeostasis in liver and kidney Cytochrome P450 F01E11.1 F01E11.1 Protein containing a UDP-glucoronosyl and UDP-glucosyl transferase domain, has low similarity to UDP-glucuronosyltransferase 8 (UDP-galactose ceramide galactosyltransferase, mouse Ugt8), which acts in the biosynthesis of galactosylceramide UDP-glucuronosyltransferase F01E11.2 F01E11.2 Protein of unknown function F01E11.3 F01E11.3 Protein of unknown function F01E11.4 F01E11.4 Member of the tetraspanin family, which contain an N-terminal transmembrane domain that is a signal sequence and membrane anchor transpanin F01E11.5 F01E11.5 Member of the rhodopsin family of G protein-coupled receptors (GPCR), has low similarity to 5-hydroxytryptamine (serotonin) 1A receptor (rat Htr1a), which acts via Gi-Go to inhibit adenylyl cyclase and plays a role in anxiety, pain, sleep and feeding G-protein coupled receptor F01F1.1 F01F1.1 Protein of unknown function, has a region of low similarity to a region of minichromosome maintenance deficient 3 associated protein (mouse Mcm3ap), which is a DNA primase that binds mouse Mcmd and may regulate development of antigen-driven B-cells F01F1.10 F01F1.10 Protein with similarity to an Arthrobacter protophormiae glucosaminidase over the amino terminus F01F1.10 encodes two isoforms of an endo-beta-N-acetylglucosaminidase (ENGase, or Endo-M); recombinant F01F1.10 has ENGase activity when expressed in E. coli, with specificity mainly for high-mannose type oligosaccharides, and optimal activity on Man8GlcNAc2; F01F1.10 has no obvious phenotype in mass RNAi screens; F01F1.10 is predicted to catabolize free oligosaccharides in the cytosol. F01F1.11 F01F1.11 Protein with strong similarity to C. elegans Y47H9C.8 gene product F01F1.12 F01F1.12 Member of the fructose-bisphosphate aldolase class-I protein family Fructose-biphosphate aldolase; The F01F1.12 gene encodes a homolog of the human gene ADHUB, which when mutated leads to fructosemia (OMIM:229600). F01F1.13 F01F1.13 Protein containing two type 1 thrombospondin domains, has a region of low similarity to a region of semaphorin 5B (semaphorin G, mouse Sema5b), which is involved in embryogenesis F01F1.14 F01F1.14 Protein of unknown function F01F1.15 F01F1.15 Protein of unknown function F01F1.2 F01F1.2 Protein of unknown function F01F1.3 F01F1.3 Protein of unknown function F01F1.4 F01F1.4 Protein containing a FYVE zinc finger domain, which bind phosphatidylinositol 3-phosphate F01F1.5 F01F1.5 Member of the prolyl oligopeptidase family and the dienelactone hydrolase family, has a region of low similarity to a region of N-acylaminoacyl-peptide hydrolase (rat Apeh), which catalyzes the release an N-acetylamino acid from an N-acetylated peptide F01F1.6 F01F1.6 Member of the aldehyde dehydrogenase family, which use NADP as a cofactor, has low similarity to mouse Aldh1a3, which is an aldehyde dehydrogenase that catalyzes the conversion of all-trans-retinaldehyde to retinoic acid Aldehyde dehydrogenase F01F1.7 F01F1.7 Member of the DEAD or DEAH box ATP-dependent RNA helicase family and contains two helicase conserved C-terminal domains, has low similarity to S. cerevisiae Prp28p, which is a pre-mRNA splicing factor required for the first covalent step of splicing RNA helicase F01F1.8 cct-6;F01F1.8 Member of the chaperonin complex family eukaryotic cytosolic chaperonin; affects viability and fertility, and is expressed in various muscle and neuronal cells: near the pharynx, near the anal sphincter, in the ventral nerve cord and the nerve ring; occasionally the expression is visible in hypodermal cells and in some vulval cells. F01F1.9 F01F1.9 Member of the peptidase Lap4p-like protein family F01G10.1 F01G10.1 Protein with high similarity to transketolase (mouse Tkt), which may transfer a two-carbon ketol from a ketose to an aldose, contains a transketolase thiamine diphosphate binding domain, C-terminal domain and pyridine binding domain transketolase; The F01G10.1 gene encodes an ortholog of the human gene TRANSKETOLASE (TKT; OMIM:606781), which when mutated leads to Wernicke-Korsakoff syndrome (OMIM:277730). F01G10.10 F01G10.10 Protein containing lipopolysaccharide-binding protein, bactericidal permeability-increasing protein, or cholesteryl ester transfer protein N-terminal and C-terminal domains, has weak similarity to uncharacterized C. elegans C55C3.1 lipopolysaccharide-binding protein like F01G10.2 F01G10.2 Protein containing 3-hydroxyacyl-CoA dehydrogenase NAD binding and C-terminal domains, which are involved in fatty acid metabolism, has low similarity to a region of rat Ehhadh, which is a hydratase and 3-hydroxyacyl coenzyme A dehydrogenase enoyl-CoA hydratase F01G10.3 F01G10.3 Protein containing a 3-hydroxyacyl-CoA dehydrogenase NAD binding domain and a 3-hydroxyacyl-CoA dehydrogenase C-terminal domain, has low similarity to a region of rat Ehhadh, which is a bifunctional hydratase and 3-hydroxyacyl coenzyme A dehydrogenase enoyl-CoA hydratase F01G10.4 F01G10.4 Protein with weak similarity to H. sapiens CENPE (centromere protein E (312kD)) F01G10.5 F01G10.5 Putative coiled-coil protein, has similarity to human MYH9, a myosin heavy polypeptide F01G10.6 F01G10.6 Protein of unknown function, predicted to contain a glycosylphosphatidylinositol (GPI) lipid anchor F01G10.7 F01G10.7 Member of the alpha or beta hydrolase fold family, has moderate similarity to lysosomal acid lipase A (human LIPA), which deacylates cholesteryl and triacylglyceryl ester lipids and is associated with Wolman disease and cholesteryl ester storage disease triacylglycerol lipase F01G10.8 daf-14;F01G10.8 A divergent member of the Smad family of small signaling molecules involved in dauer larva regulation and several additional processes Mouse MSMAD protein like; daf-14 encodes a Smad-related protein that is unusual in that while its C-terminus is well-conserved with Smad proteins, it lacks the N-terminal DNA binding domain found in all other known Smads; DAF-14 is predicted to function as a transducer of the DAF-7/TGF-beta-mediated signal that promotes reproductive growth and negatively regulates dauer formation; as reduction of daf-14 function enhances the dauer constitutive phenotype of daf-8 mutants, and overexpression of daf-14 can rescue daf-8 mutant animals, it is likely that the DAF-14 and DAF-8 Smad proteins function in parallel to control dauer formation; further genetic analyses suggest that DAF-14 and DAF-8 function to antagonize the activities of the DAF-3 Smad and DAF-5 Sno/Ski oncoprotein, which are required for dauer formation; a DAF-14::GFP reporter is expressed in a dynamic pattern in tissues, such as the hypodermis, intestine, and pharynx, that are remodeled during dauer development. F01G10.9 F01G10.9 Protein of unknown function F01G12.1 F01G12.1 Protein of unknown function, has weak similarity to C. elegans F27C1.2 F01G12.2 F01G12.2 Protein of unknown function F01G12.3 F01G12.3 Protein of unknown function F01G12.5 let-2;clb-1;sup-20;let-8;F01G12.5 Type IV collagen of basement membrane, putative ortholog of mammalian alpha2 collagen alpha-2 type IV collagen; let-2 encodes an alpha-2 type IV collagen, probably most closely equivalent to the human gene COL4A2 (OMIM:120090) on the basis of biological function; LET-2 is required for embryonic development and is a component of the basement membrane between muscle and hypodermis; LET-2 interacts with UNC-105, a mechanosensory ion channel of the degenerin ion channel superfamily that is expressed in muscle and required for normal growth, muscle contraction, and muscle organization. F01G12.6 F01G12.6 Protein with strong similarity to human Hs.179747 protein, a EVI5 homolog, a cell cycle regulator F01G4.1 psa-4;F01G4.1 Putative component of a SWI/SNF chromatin remodeling complex, active in the control of mitosis SNF2alpha like; The psa-4 (phasmid socket absent) gene encodes an ortholog of SWI2/SNF2, a component of the SWI/SNF complex that is conserved from yeast to mammals and that is involved in chromatin remodeling; psa-4 is probably required during mitosis of the T cells for asymmetric cell division. F01G4.2 F01G4.2;sad-1 Protein with high similarity to human HADH2, which is a type II hydroxyacyl-Coenzyme A dehydrogenase that binds beta-amyloid and may be associated with Alzheimer's disease, member of the short-chain dehydrogenase-reductase family short-chain alcohol dehydrogenase; ard-1 encodes a homolog of mammalian 3-hydroxyacyl-CoA dehydrogenase (HADH II)/amyloid-beta binding alcohol dehydrogenase (ABAD) that is predicted to be mitochondrial. F01G4.3 F01G4.3 Member of the DEAD or DEAH box ATP-dependent RNA helicase family and contains a helicase conserved C-terminal domain, has moderate similarity to human SKIV2L, which is an ATP-dependent RNA helicase localized in the small subunit of the ribosome antiviral protein SKI2 like F01G4.4 F01G4.4 Protein with weak similarity to C. elegans Y25C1A.L gene product F01G4.5 F01G4.5 Protein of unknown function, has low similarity to a region of phosphatidylinositol glycan class Q (human PIGQ), which is a part of the GPI-N-acetylglucosaminyl transferase enzyme complex that transfers N-acetylglucosamine from UDP to phosphatidylinositol F01G4.6 F01G4.6 Member of the mitochondrial carrier protein family of membrane transporters, has moderate similarity to mitochondrial import receptor 1 (S. cerevisiae Mir1p), which is a mitochondrial carrier phosphate transporter phosphate carrier protein precursor F02A9.1 F02A9.1 Protein of unknown function F02A9.2 F02A9.2 Protein of unknown function, has high similarity to uncharacterized C. elegans F02A9.3 O. volvulus 20Kd antigenic peptide; far-1 encodes a fatty acid/retinol binding protein; expressed throughout development with highest expression levels in L3 stage larvae and in adult males. F02A9.3 F02A9.3 Protein of unknown function, has high similarity to uncharacterized C. elegans F02A9.2 far-2 encodes a protein similar to a class of secreted fatty acid and retinol-binding proteins expressed in parasitic nematodes and secreted in the surrounding tissues of the host; expressed in body wall muscle and vulval cells of adult hermaphrodites, and transcript levels progressively increase during development. F02A9.5 F02A9.4;F02A9.5 Protein containing a carboxyl transferase domain, has low similarity to propionyl Coenzyme A carboxylase (propanoyl-CoA:carbon-dioxide ligase) beta polypeptide (human PCCB), which degrades branched-chain amino acids and has a role in propionic acidemia F02A9.6 glp-1;emb-33;F02A9.6 Notch-related receptor involved in establishment of early embryonic polarity and germ line proliferation GLP-1 protein; glp-1 encodes an N-glycosylated transmembrane protein that, along with LIN-12, comprises one of two C. elegans members of the LIN-12/Notch family of receptors; from the N- to the C-terminus, GLP-1 is characterized by ten extracellular EGF-like repeats, three LIN-12/Notch repeats, a CC-linker, a transmembrane domain, a RAM domain, six intracellular ankyrin repeats, and a PEST sequence; in C. elegans, GLP-1 activity is required for cell fate specification in germline and somatic tissues; in the germline, GLP-1, acting as a receptor for the DSL family ligand LAG-2, is essential for mitotic proliferation of germ cells and maintenance of germline stem cells; in somatic tissues, maternally provided GLP-1, acting as a receptor for the DSL family ligand APX-1, is required for inductive interactions that specify the fates of certain embryonic blastomeres; GLP-1 is also required for some later embryonic cell fate decisions, and in these decisions its activity is functionally redundant with that of LIN-12; GLP-1 expression is regulated temporally and spatially via translational control, as GLP-1 mRNA, present ubiquitously in the germline and embryo, yields detectable protein solely in lateral, interior, and endomembranes of distal, mitotic germ cells, and then predominantly in the AB blastomere and its descendants in the early embryo; proper spatial translation of glp-1 mRNA in the embryo is dependent upon genes such as the par genes, that are required for normal anterior-posterior asymmetry in the early embryo; signaling through GLP-1 controls the activity of the downstream Notch pathway components LAG-3 and LAG-1, the latter being predicted to function as part of a transcriptional feedback mechanism that positively regulates GLP-1 expression; signaling through the DNA-binding protein LAG-1 is believed to involve a direct interaction between LAG-1 and the GLP-1 RAM and ankyrin domains. F02C12.1 F02C12.1 Protein of unknown function F02C12.2 F02C12.2 Member of the short-chain dehydrogenase-reductase family, which are NAD- or NADP-dependent oxidoreductases, has low similarity to human HSA250303, which is a peroxisomal trans 2-enoyl CoA reductase glucose 1-dehydrogenase; This gene encodes a protein predicted by Eisenberg and coworkers, with 68% accuracy, to be mitochondrial. F02C12.3 F02C12.3 Protein of unknown function F02C12.4 F02C12.4 Protein containing one DUF41 domain of unknown function F02C12.5 F02C12.5 Member of the cytochrome P450 family, has low similarity to cytochrome P450 subfamily 3a polypeptide 9 (rat Cyp3a9), which is a sexually dimorphically expressed enzyme that demethylates erythromycin and benzphetamine cytochrome P450 F02C9.1 F02C9.1 Protein of unknown function F02C9.2 F02C9.2 Protein of unknown function, has high similarity to uncharacterized C. elegans F56A4.6 F02C9.3 F02C9.3 Member of the P-type ATPase, Drs2p subfamily protein family ATPase F02C9.4 F02C9.4 Protein of unknown function, has weak similarity to C. elegans F45C12.1 F02D10.1 F02D10.1 Protein with high similarity to C. elegans DPY-16, which is a collagen, contains a nematode cuticle collagen N-terminal domain cuticle collagen F02D10.2 F02D10.2 Protein of unknown function F02D10.3 F02D10.3 Protein of unknown function F02D10.4 F02D10.4 Protein of unknown function F02D10.5 F02D10.5 Protein with very strong similarity to C. elegans FLR-1, which is a membrane protein that confers wild-type sensitivity to fluoride, member of the amiloride-sensitive sodium channel family, which are involved in sodium reabsorption sodium channel like F02D10.6 F02D10.6 Protein of unknown function, has moderate similarity to uncharacterized C. elegans C49F5.3 F02D10.7 F02D10.7 Protein containing a SET domain, which are involved in protein-protein interactions, has weak similarity to a region of C. elegans MES-4, which is a putative G protein-coupled receptor expressed in chemosensory neurons trithorax like protein F02D8.1 F02D8.1 Protein of unknown function F02D8.2 F02D8.2 Protein of unknown function containing a Ground-like domain, has weak similarity to C. elegans grd-9 F02D8.3 F02D8.3 Protein of unknown function, has low similarity to uncharacterized CGI-60 (human LOC51626) F02D8.4 F02D8.4 Member of the carboxypeptidase A metalloprotease (M14) family of zinc carboxypeptidases, has moderate similarity to a region of carboxypeptidase B1 (rat Cpb1), which is a primary manganese-binding protein in the pancreas carboxypeptidase F02E11.1 F02E11.1 Member of the ABC transporter family, has low similarity to ATP-binding cassette subfamily G member 1 (mouse Abcg1), which is an ABC transporter involved in cellular sterol homeostasis ABC transpoter F02E11.2 F02E11.2 Protein of unknown function F02E11.3 F02E11.3 Protein of unknown function F02E11.4 F02E11.4 Protein of unknown function, has high similarity to uncharacterized C. elegans Y110A2AL.1 F02E11.5 F02E11.5 Member of the SCP-like extracellular protein family, has low similarity to a region of specific granule protein 28kDa (human SGP28), which is a widely expressed and localizes to specific granules in neutrophils F02E8.1 F02E8.1 Protein of unknown function, has high similarity to uncharacterized C. elegans F35G12.10 ATP synthase B chain; asb-2 encodes a ATP synthase B homolog. F02E8.2 F02E8.2 Member of the rhodopsin family of G protein-coupled receptors (GPCR), has low similarity to G protein-coupled receptor FM-3 (rat Gpr66), which is predicted to bind neuromedin U (rat Nmu) G-protein coupled receptor F02E8.3 aps-2;F02E8.3 Member of the clathrin-associated protein family with 92% identity to mammalian Ap-17 Clathrin coat assembly protein; The aps-2 gene encodes an adaptin: specifically, it encodes an ortholog of the sigma2 subunit of adaptor protein complex 2 (AP-2), which mediates endocytosis from the plasma membrane; APS-2 appears to be required for embryonic and larval development and for normal body morphology, but is not required for endocytosis of yolk protein in developing oocytes; APS-2 is expressed in nearly all cells during embryogenesis, but during larval and adult stages, expression is confined to neurons and some hypodermal cells, including vulval hypodermal cells during the fourth larval stage. F02E8.4 F02E8.4 Protein of unknown function, has low similarity to uncharacterized C. elegans R09A8.2 F02E8.5 F02E8.5 Protein containing seven WD domains (WD-40 repeat), which may mediate protein-protein interactions, has weak similarity to S. cerevisiae Mdv1p, which is a protein involved in mitochondrial division F02E8.6 npc-1;F02E8.6 Functions in cholesterol metabolism and possibly general vesicular trafficking and has strong similarity to human NPC1, which is associated with the lysosomal storage disease Niemann-Pick type C ncr-1 encodes a large transmembrane glycoprotein with a patched-like domain that is orthologous to human NPC1 (OMIM:257220, mutated in Niemann-Pick type C disease); NCR-1 and NPC1 are eukaryotic members of the resistance-nodulation-division (RND) family of membrane permeases, and have a putative sterol-sensing domain; by homology, NCR-1 is predicted to function in intracellular cholesterol and glycolipid trafficking; in C. elegans, NCR-1 is required for growth and survival in the absence of cholesterol, newly hatched ncr-1 mutant larvae grow poorly on cholesterol-free medium and die at the L1 or L2 stage; NCR-1 is also involved in negative regulation of dauer formation, being required redundantly with NCR-2, a second C. elegans NPC1-like protein, for preventing constitutive dauer formation; dauer formation in ncr-1; ncr-2 double mutants is suppressed by mutations in daf-12, which encodes a steroid hormone receptor, and by overexpression of daf-9, which encodes a cytochrome P450, suggesting that NCR-1 and NCR-2 may function to transport a sterol precursor that is metabolized by DAF-9 to then serve as the DAF-12 ligand. F02E9.1 F02E9.1 Protein of unknown function F02E9.10 F02E9.10 Protein with weak similarity to C. elegans R06A4.9 gene product F02E9.2 lin-28;F02E9.2 Protein required for developmental timing of the ectoderm and cuticle; has weak similarity to H. sapiens YB1 gene product cold shock domain; lin-28 encodes a cytoplasmic protein with a cold shock domain and retroviral-type (CCHC) zinc finger motifs; LIN-28 is required for events specific to the second larval stage, which in lin-28 mutants are skipped, and is itself subject both to negative regulation (by binding of the lin-4 stRNA to an element in the lin-28 3' UTR) and to positive regulation (by LIN-14, which negatively regulates lin-4-independent inhibition also acting on the lin-28 3' UTR). F02E9.3 F02E9.3 Protein of unknown function, has moderate similarity to uncharacterized C. elegans C47E12.11 ubiquitin carboxyl-terminal hydrolase F02E9.4 F02E9.4 Protein containing a paired amphipathic helix repeat, which may mediate protein-protein interactions, has weak similarity to transcriptional regulator SIN3 yeast homolog B (mouse Sin3b), which functions as a transcriptional co-repressor pqn-28 encodes an ortholog of the SIN3 family of histone deacetylase subunits, which also has a glutamine/asparagine-rich domain, possibly involved in epigenetic regulation; pqn-28 has no obvious phenotype in mass RNAi screens; on the basis of its homology, PQN-28, when activated by promoter-specific transcription factors, is expected to work in conjunction with other histone deacetylase components to induce chromatin silencing; PQN-28 may also silence genes by colocating to them with the O-GlcNAc transferase homolog OGT-1. F02E9.5 F02E9.5 Protein of unknown function F02E9.6 F02E9.6 Putative ortholog of S. cerevisiae Yol057p, a protein of unknown function F02E9.7 F02E9.7 Member of the purple acid phosphatase family, which catalyze hydrolysis of phosphate esters, has moderate similarity to human ACP5, which is a binuclear redox-sensitive iron-containing lysosomal phosphatase secreted into serum during bone resorption acid phosphatase F02E9.9 F02E9.9 Protein with moderate similarity to D. melanogaster CG7415 (CG7415 gene product) WD domain, G-beta repeat F02G3.1 F02G3.1 Protein containing ten immunoglobulin (Ig) domains, which may be involved in protein interactions, and four fibronectin type III domains, which are involved in cell surface binding, has weak similarity to neural cell adhesion molecule (rat Ncam1) neural cell adhesion molecule F02H6.1 F02H6.1 Protein with moderate similarity to C. elegans K01G12.3 gene product F02H6.2 F02H6.2 Putative ortholog of C. elegans K01G12.3 gene product F02H6.3 F02H6.3 Protein of unknown function F02H6.4 F02H6.4 Protein with strong similarity to C. elegans W06D11.5 gene product F02H6.5 F02H6.5 Protein with similarity to S. pombe HMT2 sulfide oxidation/cadmium resistance protein F02H6.6 F02H6.6 Protein of unknown function, has high similarity to uncharacterized C. elegans F02H6.7 F02H6.7 F02H6.7 Protein of unknown function, has high similarity to uncharacterized C. elegans F02H6.6 F07A11.1 F07A11.1 Protein with weak similarity to C. elegans D1044.6 F07A11.2 F07A11.2 Protein with high similarity to glutamine-fructose-6-phosphate transaminase 1 (mouse Gfpt1), which catalyzes the first step in glucosamine formation, contains four sugar isomerase (SIS) domains and two glutamine amidotransferases class II domains glucosamine-fructose-6-phosphate aminotransferase F07A11.3 F07A11.3 Protein of unknown function F07A11.4 F07A11.4 Member of the ubiquitin carboxyl-terminal hydrolase family 2, contains MYND finger and UCH-1 domains, has a region of low similarity to ubiquitin specific protease 11 (human USP11), which is involved in protein deubiquination ubiquitin carboxyl-terminal hydrolase F07A11.5 F07A11.5 Member of the PfkB family of carbohydrate kinases, has low similarity to ribokinase (S. cerevisiae Rbk1p), which is involved in temperature response ribokinase F07A11.6 F07A11.6 Protein of unknown function, has weak similarity to a region of SMRT and HDAC1 associated repressor protein (human SHARP), which is a transcriptional repressor that regulates liganded and nonliganded nuclear receptors RNA recognition motif. (aka RRM, RBD, or RNP domain) F07A5.1 opu-14;inx-14;F07A5.1 Member of the integral membrane innexin family, which are involved in the formation of gap junctions, has weak similarity to C. elegans INX-3, which is an innexin that forms connexin-like intercellular channels UNC-7 like; inx-14 encodes a predicted member of the innexin family that affects embryonic viability and fertility. F07A5.2 F07A5.2 Protein of unknown function F07A5.3 F07A5.3 Member of the CD36 family of putative scavenger receptors, has weak similarity to scavenger receptor BI (mouse Srb1), which mediates the selective uptake of cholesterol from high and low density lipoproteins and activates endothelial nitric oxide membrane glycoprotein F07A5.4 F07A5.4 Protein of unknown function F07A5.5 F07A5.5 Protein containing a C2 domain, which may be involved in calcium-dependent phospholipid binding C2 domain F07A5.6 F07A5.6 Protein of unknown function F07A5.7 unc-15;F07A5.7 Paramyosin, major component of muscle filaments, structural equivalent of the rod region of myosin heavy chains paramyosin; The unc-15 gene encodes a paramyosin ortholog; UNC-15 protein physically interacts with MHC A, one isoform of myosin heavy chain (MHC) in striated muscle; UNC-15 accumulation is decreased in the absence of UNC-54 (myosin B), implying that degradation of UNC-15 is inhibited by its binding myosin B; conversely, myosin B (but not MYO-3/myosin A) fails to accumulate in unc-15 mutants. F07B10.1 cln-3.1;F07B10.1 Member of the CLN3 protein family, has moderate similarity to ceroid-lipofuscinosis neuronal 3 (human CLN3), which plays a role in lysosomal pH homeostasis and is associated with juvenile Batten disease Human CLN3 protein like; cln-3.1 is orthologous to the human gene CEROID-LIPOFUSCINOSIS, NEURONAL 3, JUVENILE (BATTEN, SPIELMEYER-VOGT DISEASE) (CLN3; OMIM:607042), which when mutated leads to disease. F07B10.2 F07B10.2 Member of the 7-transmembrane chemoreceptor family of G protein-coupled receptors (GPCR), has low similarity to C. elegans ODR-10, which is involved in odorant response 7TM receptor F07B10.3 F07B10.3 Member of the 7-transmembrane chemoreceptor family of G protein-coupled receptors (GPCR), has low similarity to C. elegans ODR-10, which is involved in odorant response 7TM receptor F07B7.10 F07B7.10 Protein with strong similarity to C. elegans B0035.7 gene product his-51 encodes an H2A histone. F07B7.11 F07B7.11 Putative ortholog of C. elegans F07B7.4 gene product his-54 encodes an H2B histone; by homology, HIS-54 is predicted to function as a nucleosome component required for packaging of DNA into chromatin. F07B7.3 F07B7.3 Protein with strong similarity to C. elegans B0035.7 gene product his-53 encodes an H2A histone. F07B7.4 F07B7.4 Putative ortholog of C. elegans F07B7.11 gene product his-52 encodes an H2B histone. F07B7.6 F07B7.6 Putative ortholog of C. elegans C03A7.1 gene product F07B7.8 F07B7.8 Putative ortholog of C. elegans K06C4.1 gene product F07B7.A F07B7.14;F07B7.A Putative ortholog of C. elegans W09B7.A gene product F07B7.B F07B7.13;F07B7.B Putative ortholog of C. elegans C01B7.7 gene product F07B7.C F07B7.12;F07B7.C Putative ortholog of C. elegans rpm-1 gene product F07B7.E F07B7.9;F07B7.E Protein with strong similarity to C. elegans B0035.9 gene product F07B7.H F07B7.7;F07B7.H Putative ortholog of C. elegans ZC411.1 gene product F07B7.L F07B7.5;F07B7.L Putative ortholog of C. elegans B0035.10 gene product F07B7.N F07B7.2;F07B7.N Putative ortholog of C. elegans W09B7.B gene product F07B7.O F07B7.1;F07B7.O Putative ortholog of C. elegans W09B7.C gene product F07C3.1 ptd-2;F07C3.1 Protein with weak similarity to C. elegans CHE-14, which is required for normal chemotaxis towards water-soluble chemicals as well as secretory processes in the hypodermis and the amphid support cells F07C3.10 F07C3.10 Protein containing nuclear hormone receptor ligand-binding and C4-type zinc finger domains, which bind DNA and may be involved in regulation of transcription, has a region of low similarity to peroxisome proliferator activated receptor delta (mouse Ppard) zinc finger protein F07C3.2 F07C3.2 Protein of unknown function F07C3.3 F07C3.3 Member of uncharacterized DUF229 family, has low similarity to uncharacterized C. elegans M03F8.5 F07C3.4 F07C3.4 Protein containing five regulator of chromosome condensation (RCC1) repeat domains, has a region of low similarity to a region of HECT (homologous to E6-AP (UBE3A) carboxy terminus) domain and RCC1 (CHC1)-like domain (RLD) 1 (human HERC1) guanine-nucleotide releasing factor; The F07C3.4 gene encodes a guanine-nucleotide releasing factor homolog that is homologous to human RP3. F07C3.5 F07C3.5 Protein of unknown function F07C3.7 F07C3.7 Member of the amino acid permease family, putative ortholog of human cationic amino acid transporters SLC7A6, SLC7A7, and y+LAT1 amino acid permease F07C3.8 str-94;F07C3.8 Member of the 7-transmembrane chemoreceptor family of G protein-coupled receptors (GPCR), has low similarity to C. elegans ODR-10, which is involved in odorant response 7TM chemoreceptor, str family F07C3.9 F07C3.9 Protein of unknown function F07C4.1 F07C4.1 Member of the 7-transmembrane chemoreceptor family of G protein-coupled receptors (GPCR), has weak similarity to C. elegans ODR-10, which is involved in odorant response 7TM chemoreceptor, str family F07C4.10 F07C4.10 Protein containing one DUF18 domain of unknown function, has high similarity to uncharacterized C. elegans T05B4.12 F07C4.11 F07C4.11 Protein containing one DUF18 domain of unknown function F07C4.12 F07C4.12 Member of the carboxylesterase protein family carboxylesterase F07C4.13 F07C4.13 Member of the 7-transmembrane chemoreceptor family of G protein-coupled receptors (GPCR), has high similarity to uncharacterized C. elegans R03H4.9 7TM chemoreceptor, srh family F07C4.14 F07C4.14 Putative ortholog of C. elegans F08E10.1 gene product 7TM chemoreceptor, srh family F07C4.2 EF07C4.2;F07C4.2 Member of the C-type lectin family, has weak similarity to human C-type mannose receptor MRC1 F07C4.3 F07C4.3 G protein-coupled receptor, member of a subfamily with SRD proteins which are expressed in chemosensory neurons, no homolog found in human or D. melanogaster 7TM chemoreceptor, srd family F07C4.4 F07C4.4 Protein of unknown function, has high similarity to uncharacterized C. elegans F07C4.5 7TM chemoreceptor, srd family F07C4.5 F07C4.5 Protein of unknown function, has high similarity to uncharacterized C. elegans F07C4.8 7TM chemoreceptor, srd family F07C4.6 F07C4.6 Protein containing one DUF18 domain of unknown function, has high similarity to uncharacterized C. elegans F35E8.9 F07C4.7 F07C4.7 Protein of unknown function F07C4.8 F07C4.8 Protein of unknown function, has high similarity to uncharacterized C. elegans F07C4.5 7TM chemoreceptor, srd family F07C4.9 F07C4.9 Member of the C-type lectin family F07C6.1 pin-2;F07C6.1 LIM-only protein of the PINCH family of LIM-only proteins, putative paralog of C. elegans UNC-97, putative ortholog of human LIMS1 LIM domains F07C6.2 F07C6.2 Protein of unknown function F07C6.3 F07C6.3 Protein of unknown function, has high similarity to uncharacterized C. elegans C08F11.1 F07C6.4 F07C6.4 Protein of unknown function F07C7.1 F07C7.1 Member of the reverse transcriptase family, which are RNA-dependent DNA polymerases, contains a retroviral integrase core domain, which are central catalytic domains that can act as endonucleases, has high similarity to uncharacterized C. elegans T23B12.9 F07D10.1 F07D10.1 Protein with strong similarity to ribosomal protein L11 (human RPL11), which interacts with the cysteine proteinase bleomycin hydrolase (human BLML), member of the ribosomal L5 family, contains a ribosomal L5P C-terminal domain ribosomal protein; rpl-11.2 encodes a large ribosomal subunit L11 protein; by homology, RPL-11.2 is predicted to function in protein biosynthesis. F07D3.1 F07D3.1 Putative ortholog of C. elegans H24G06.1 gene product F07D3.2 flp-6;F07D3.2 KSAYMRF-amide neurotransmitter FMRFAMIDE-related peptide F07D3.3 F07D3.3 Protein with weak similarity to C. elegans T07F10.3 gene product F07E5.1 F07E5.1 Protein containing an F-box domain, which serve as a link between a target protein and a ubiquitin-conjugating enzyme This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins. F07E5.2 F07E5.2 Member of an uncharacterized protein family This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins; its encoded protein also contains a Pfam-B45 motif of presently unknown function. F07E5.4 F07E5.4 Protein with strong similarity to C. elegans T27E7.1 gene product F07E5.5 F07E5.5 Protein containing four zinc knuckle domains, which can bind eukaryotic RNA or DNA, has a region of low similarity to a region of S. pombe Byr3p, which is a DNA binding protein involved in conjugation and sporulation zinc-finger protein F07E5.6 F07E5.6 Putative ortholog of C. elegans F07E5.2 gene product F07E5.7 F07E5.7 Protein containing a DUF130 domain of unknown function, has high similarity to uncharacterized C. elegans R52.5 F07E5.8 F07E5.8 Protein containing one WSN domain of unknown function, has high similarity to uncharacterized C. elegans T16A1.2 F07E5.9 F07E5.9 Protein of unknown function F07F6.1 F07F6.1 Protein of unknown function F07F6.2 F07F6.2 Protein of unknown function F07F6.4 F07F6.4 Protein containing two putative arf GTPase activation (GAP) domains, which have C-4 class zinc fingers, has moderate similarity to ADP-ribosylation factor GTPase-activating protein 1 (human ARFGAP1), which is involved in the protein secretory pathway Zinc finger protein F07F6.5 F07F6.5 Protein with moderate similarity to C. elegans C29G2.6 gene product F07F6.6 nmr-1;F07F6.6 NMDA-type glutamate receptor, involved in locomotion behavior Glutamate receptor; nmr-1 encodes an NMDA-type ionotropic glutamate receptor subunit that affects the duration of forward movement which is important during foraging behavior, and also affects osmotic avoidance; the slow kinetics typical of NMDA-dependent currents are likely important for its effect on forward movement. F07F6.7 F07F6.7 Putative ortholog of C. elegans F07F6.8 gene product F07F6.8 F07F6.8 Putative ortholog of C. elegans F07F6.7 gene product F07F6.9 F07F6.9 Putative ortholog of C. elegans C14C11.5 gene product 7TM chemoreceptor, srx family F07G11.1 F07G11.1 Member of the domain of unknown function DUF13 family, has strong similarity to uncharacterized C. elegans C13A2.9 F07G11.2 F07G11.2 Member of the domain of unknown function DUF13 family, has strong similarity to uncharacterized C. elegans C13A2.10 F07G11.3 F07G11.3 Protein containing one DUF23 domain of unknown function, has high similarity to uncharacterized C. elegans F07G11.4 F07G11.4 F07G11.4 Protein containing one DUF23 domain of unknown function, has high similarity to uncharacterized C. elegans F07G11.3 F07G11.5 srj-32;F07G11.5 Member of the 7-transmembrane chemoreceptor family of G protein-coupled receptors (GPCR), has a region of weak similarity to C. elegans ODR-10, which is a G protein-coupled receptor involved in odorant response 7TM chemoreceptor, srj family F07G11.7 F07G11.7 Member of the domain of unknown function DUF13 family F07G11.8 F07G11.8 Protein of unknown function, has high similarity to uncharacterized C. elegans Y49C4A.4 7TM chemoreceptor, srx family F07G11.9 F07G11.9 Member of the glycosyl hydrolase 18 family, contains twelve LysM domains, which may bind peptidoglycans, has a region of low similarity to chitinase 1 (chitotriosidase, human CHIT1), which hydrolyzes chitin and is implicated in chitotriosidase deficiency F07G6.1 F07G6.1 Protein with moderate similarity to C. elegans F56C3.6 gene product F07G6.2 F07G6.2 Protein of unknown function F07G6.3 F07G6.3 Protein of unknown function, has high similarity to uncharacterized C. elegans Y67D8C.2 F07G6.5 F07G6.5 Protein of unknown function F07G6.6 F07G6.6 Protein containing one DUF38 domain of unknown function, has high similarity to uncharacterized C. elegans T12B5.10 F07G6.7 F07G6.7 Protein containing one DUF38 domain of unknown function F07G6.8 F07G6.8 Protein of unknown function F07H5.10 F07H5.10 Protein with weak similarity to C. elegans dom-3 gene product F07H5.12 F07H5.12 Protein of unknown function F07H5.13 F07H5.13 Protein of unknown function F07H5.2 F07H5.2 Protein with moderate similarity to delta sarcoglycan (mouse Sgcd), which is a component of the dystrophin-glycoprotein complex gamma-sarcoglycan F07H5.3 F07H5.3 Protein of unknown function F07H5.4 F07H5.4 Protein of unknown function F07H5.6 F07H5.6 Protein of unknown function F07H5.7 F07H5.7 Protein of unknown function F07H5.8 F07H5.8 Protein containing 22 uncharacterized DUF139 cysteine repeat domains, has low similarity to uncharacterized C. elegans C14C11.8 keratin like F07H5.9 F07H5.9 Member of the histidine acid phosphatase family, which hydrolyze phosphate esters at low pH, has low similarity to human ACP2, which is a tartrate-inhibitable lysosomal acid phosphatase acid phosphatase F08A10.1 F08A10.1 Protein containing a calmodulin binding domain, has a region of high similarity to Ca2+-activated small-intermediate conductance potassium channel 2 (human KCNN2), which is a voltage-independent K+ channel F08A8.1 F08A8.1 Member of the acyl-CoA oxidase family, which convert acyl-CoA into trans-2-enoyl-CoA, has moderate similarity to peroxisomal acyl-coenzyme A oxidase (rat RATACOA1), which catalyzes the first step in very long chain fatty acid beta-oxidation ACYL-COENZYME A OXIDASE, PEROXISOMAL (EC 1.3.3.6) (PALMITOYL-COA OXIDASE) (AOX); F08A8.1 is orthologous to the human gene ACYL-CoA OXIDASE 1, PALMITOYL (ACOX1; OMIM:264470), which when mutated leads to pseudoneonatal adrenoleukodystrophy. F08A8.2 F08A8.2 Member of the acyl-CoA oxidase family, which convert acyl-CoA into trans-2-enoyl-CoA, has moderate similarity to peroxisomal acyl-coenzyme A oxidase (rat RATACOA1), which catalyzes the first step in very long chain fatty acid beta-oxidation ACYL-COENZYME A OXIDASE, PEROXISOMAL (EC 1.3.3.6) (PALMITOYL-COA OXIDASE) (AOX) F08A8.3 F08A8.3 Member of the acyl-CoA oxidase family, which convert acyl-CoA into trans-2-enoyl-CoA, has moderate similarity to peroxisomal acyl-coenzyme A oxidase (rat RATACOA1), which catalyzes the first step in very long chain fatty acid beta-oxidation ACYL-COENZYME A OXIDASE, PEROXISOMAL (EC 1.3.3.6) (PALMITOYL-COA OXIDASE) (AOX) F08A8.4 F08A8.4 Member of the acyl-CoA oxidase family, which convert acyl-CoA into trans-2-enoyl-CoA, has moderate similarity to peroxisomal acyl-coenzyme A oxidase (rat RATACOA1), which catalyzes first step in very long chain fatty acid beta-oxidation ACYL-COENZYME A OXIDASE, PEROXISOMAL (EC 1.3.3.6) (PALMITOYL-COA OXIDASE) (AOX) F08A8.5 F08A8.5 Member of an uncharacterized protein family F08A8.6 F08A8.6 Protein containing an epsin N-terminal homology (ENTH) domain, has low similarity to a region of huntingtin interacting protein 1 related protein (mouse Hip1r), which binds F-actin, clathrin, and possibly phosphatidylinositol 4,5 bisphosphate F08A8.7 F08A8.7 Protein of unknown function, putative paralog of C. elegans C47B2.1 F08B1.1 vhp-1;F08B1.1 Protein containing two dual specificity phosphatase catalytic domains, has low similarity to human DUSP8, which is a dual specificity protein phosphatase that dephosphorylates and inactivates mitogen-activated protein kinase in vitro protein tyrosine phosphatase F08B1.2 gcy-12;F08B1.2 Guanylyl cyclase expressed in the PHA sensory neurons guanylate cyclase; gcy-12 encodes a predicted guanylate cyclase that affects chemotaxis to isoamyl alcohol; expressed in PHA neurons and in AFD neurons. F08B1.3 F08B1.3 Protein of unknown function F08B12.1 F08B12.1 Protein with weak similarity to prominin (mouse Prom), which is a cell surface antigen that may play roles in the establishment and maintenance of cell polarity and photoreceptor disk morphogenesis F08B12.1 is orthologous to the human gene AC133-2 ANTIGEN (PROML1; OMIM:604365), which when mutated leads to disease. F08B12.2 F08B12.2 Protein with moderate similarity to peroxisomal biogenesis factor 12 (human PEX12), which is a peroxisomal integral membrane protein that interacts with PXR1 and PEX10 and is involved in peroxisomal matrix protein import Zinc finger, C3HC4 type (RING finger) F08B12.3 slo-2;nSlo2;F08B12.3 Expressed in neurons and is a member of the calcium-activated Slo potassium channel family F08B12.4 F08B12.4;XM26 Protein of unknown function F08B4.1 F08B4.1 Protein of unknown function, has low similarity to uncharacterized deleted in cancer 1 (human DDX26), which is a candidate tumor suppressor that is downregulated in non-small cell lung carcinomas dic-1 encodes an ortholog of Drosophila CG3125 and human DEAD/H BOX 26 (DDX26, DICE-1; OMIM:604331; nuclear protein, lost or downregulated in nonsmall cell lung carcinomas); DIC-1 and its orthologs have an N-terminal von Willebrand factor (vWF) type A domain; DIC-1 is required for embryonic development and normal locomotion. F08B4.2 cdh-5;F08B4.2 Protein containing fourteen cadherin domains, which are found in the extracellular domain of some receptors and cell adhesion proteins, has weak similarity to a region of cadherin 23 (otocadherin, mouse Cdh23), which is involved in sensorineural hearing cadherin repeat-containing protein; a homolog of cadherin. F08B4.3 F08B4.3 Protein with moderate similarity to C. elegans wee-1.3 gene product F08B4.4 F08B4.4 Protein of unknown function F08B4.5 F08B4.5 Protein with low similarity to polymerase epsilon 2 (human POLE2), which is an accessory subunit of DNA polymerase epsilon that binds the catalytic subunit and stabilizes the polymerase complex F08B4.6 ndst;F08B4.6 Member of the sulfotransferase family, has moderate similarity to N-deacetylase N-sulfotransferase 1 (rat Ndst1), which is an enzyme that catalyzes N-deacetylation and N-sulfation of N-acetylglucosamine in heparan sulfate and heparin biosynthesis N-heparan sulfate sulfotransferase F08B4.7 F08B4.7 Protein with high similarity to small nuclear ribonucleoprotein polypeptide C (human SNRPC), which binds U1 snRNP particle and promotes the formation of the early spliceosomal complexes and is involved in transcriptional regulation U1 small nuclear ribonucleoprotein C F08B6.1 F08B6.F;F08B6.1 Protein of unknown function F08B6.2 gpc-2;F08B6.E;F08B6.2 Weakly similar to H. sapiens GNG11, guanine nucleotide binding protein 11; required to control mitotic spindle orientation gpc-2 encodes one of two C. elegans heterotrimeric G protein gamma subunits; gpc-2 is required, along with its partner GPB-1, a G protein beta subunit, for proper mitotic spindle positioning and orientation during early embryonic cell divisions; to date, GPC-2 expression has been reported in electrically excitable cells (all neurons and muscles). F08B6.3 F08B6.C;F08B6.3 Protein containing five EF hand domains, which are found in signaling, buffering or transport proteins, has low similarity to reticulocalbin 2 (rat Rcn2), which is an endoplasmic reticulum calcium-binding protein that binds the snake venom toxin taipoxin EF hand protein F08B6.4 unc-87;F08B6.B;F08B6.4 Actin-bundling protein; associated with muscle thin filaments calponin; unc-87 encodes, through alternative splicing, two proteins that are required to maintain the structure of myofilaments in body wall muscle cells; UNC-87 proteins resemble the C-terminal repeat region of calponin but have no obvious orthologs outside of nematodes; in vitro, UNC-87 proteins exist as monomers in solution, associate with thin (F-actin) filaments but not with monomeric G-actin, and bundle F-actin filaments; in vivo, UNC-87 proteins reside in the I-band of bodywall muscle, and GFP-tagged UNC-87 associates with actin stress fibers; unc-87 mutants show degeneration of myofilaments, are profoundly immobile, and have noticeable defects in egg-laying; the unc-87 mutant phenotype is partially suppressed by the unc-54(s95) mutation, which lowers myosin activity but leaves myofilaments intact, indicating that UNC-87 prevents damage by mechanical stress on myofilaments. F08C6.2 CCt;F08C6.2 CTP:phosphocholine cytidyltransferase cholinephosphate cytidylyltransferase; F08C6.2 encodes a lipid-activated CTP:phosphocholine cytidylyltransferase (CCT), with CCT activity in vitro; recombinant F08C6.2 enzyme is most activated by a 1:1 mixture of phosphatidylcholine:oleate vesicles; a inhibitory 21-residue segment (residues 246-266) is critical for specific activation of F08C6.2 by lipids, since deletion or mutation of this segment causes F08C6.2 to be constitutively active without its normal lipid substrate; F08C6.2 has no obvious function in mass RNAi assays. F08C6.3 F08C6.3 Protein of unknown function, has low similarity to uncharacterized suppressor of actin mutation 2-like (human SACM2L) F08C6.4 sto-1;F08C6.4 Protein with high similarity to erythrocyte membrane protein band 7.2 (stomatin, human EPB72), which may participate in ion channel permeability and mechanoreception and may be associated with stomatocytosis, member of the SPFH domain or Band 7 family Erythrocyte band 7 integral membrane protein (human) F08C6.5 F08C6.5 Protein of unknown function F08C6.6 F08C6.6 Protein with weak similarity to C. elegans Y39F10A.2 gene product F08C6.7 F08C6.7 Protein containing three C2H2 type zinc finger domains, which bind nucleic acids, has a region of low similarity to a region of zinc-finger protein 91 (human ZNF91), which functions as a transcriptional repressor Zinc finger; unc-98 encodes a protein with four C2H2 zinc fingers and several possible nuclear localization and export sequences; UNC-98 is required for normal mobility, M-line structures, and dense body (Z-line analog) structures; UNC-98 binds UNC-97/PINCH, HUM-6, and MEP-1; UNC-98 is located in M-lines, muscle cell nuclei, and perhaps dense bodies. F08D12.1 F08D12.1 Protein containing three TPR (tetratrico peptide repeat) domains, which may mediate protein-protein interactions, has low similarity to uncharacterized signal recognition particle 72 (human SRP72) signal recognition particle protein F08D12.10 F08D12.10 Protein containing an F-box domain, which serve as a link between a target protein and a ubiquitin-conjugating enzyme, has high similarity to uncharacterized C. elegans F08D12.9 This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins; its encoded protein also contains a Pfam-B45 motif of presently unknown function. F08D12.11 F08D12.11 Protein containing an F-box domain, which serve as a link between a target protein and a ubiquitin-conjugating enzyme, has moderate similarity to uncharacterized C. elegans F08D12.9 This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins; its encoded protein also contains a Pfam-B45 motif of presently unknown function. F08D12.12 F08D12.12 Protein of unknown function F08D12.13 F08D12.13 Protein of unknown function F08D12.2 F08D12.2 Protein of unknown function, has moderate similarity to uncharacterized C. elegans F08D12.3 F08D12.3 F08D12.3 Protein of unknown function, has moderate similarity to uncharacterized C. elegans F08D12.2 F08D12.4 F08D12.4 Putative ortholog of C. elegans F08D12.5 gene product F08D12.5 F08D12.5 Protein of unknown function, has strong similarity to C. elegans F08D12.4 F08D12.6 F08D12.6 Protein containing an F-box domain, which serve as a link between a target protein and a ubiquitin-conjugating enzyme This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins; its encoded protein also contains a Pfam-B45 motif of presently unknown function. F08D12.7 F08D12.7 Protein of unknown function, has low similarity to uncharacterized C. elegans F40G12.5 F08D12.8 F08D12.8 Protein containing an F-box domain, which serve as a link between a target protein and a ubiquitin-conjugating enzyme, has moderate similarity to uncharacterized C. elegans F29A7.1 This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins; its encoded protein also contains a Pfam-B45 motif of presently unknown function. F08D12.9 F08D12.9 Protein containing an F-box domain, which serve as a link between a target protein and a ubiquitin-conjugating enzyme, has high similarity to uncharacterized C. elegans F08D12.10 This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins; its encoded protein also contains a Pfam-B45 motif of presently unknown function. F08E10.1 F08E10.1 Member of the 7-transmembrane chemoreceptor family of G protein-coupled receptors (GPCR), has strong similarity to uncharacterized C. elegans T26H5.3 F08E10.2 F08E10.2 Protein containing one DUF40 domain of unknown function, which contain four conserved cysteines, has strong similarity to uncharacterized C. elegans T19C9.1 7TM receptor, srbc family F08E10.3 F08E10.3 Member of the 7-transmembrane chemoreceptor family of G protein-coupled receptors (GPCR), has high similarity to uncharacterized C. elegans Y102A5C.21 F08E10.4 F08E10.4 Member of the 7-transmembrane chemoreceptor family of G protein-coupled receptors (GPCR), has high similarity to uncharacterized C. elegans T19C9.4 F08E10.5 F08E10.5 Member of the 7-transmembrane chemoreceptor family of G protein-coupled receptors (GPCR), has strong similarity to uncharacterized C. elegans T19C9.3 F08E10.6 F08E10.6 Member of the 7-transmembrane chemoreceptor family of G protein-coupled receptors (GPCR), has strong similarity to uncharacterized C. elegans T19C9.2 F08E10.7 F08E10.7 Member of an uncharacterized protein family F08F1.1 kin-9;F08F1.1 Protein containing two protein kinase domains, has a region of moderate similarity to a region of fibroblast growth factor receptor 4 (human FGFR4), which is a receptor protein tyrosine kinase that binds acidic FGF and functions in cell differentiation protein-tyosine kinase; kin-9 encodes a predicted protein tyrosine kinase. F08F1.3 F08F1.3 Protein of unknown function F08F1.4 F08F1.4 Protein of unknown function F08F1.5 ced-8;F08F1.5 Appears to have a role in the modulation of the kinetics of cell corpse engulfment during development The ced-8 gene encodes a homolog of the human putative membrane transporter XK; ced-8 is required for apoptosis to occur with normal speed during embryonic development. F08F1.6 F08F1.6 Protein of unknown function F08F1.7 F08F1.7;Emp70 Member of the COPII coat protein, Emp70p-like protein family F08F1.8 F08F1.8 Protein with weak similarity to D. melanogaster EG:EG0007.11 F08F1.9 F08F1.9 Protein containing a cyclin N-terminal domain, has a region of high similarity to a region of cyclin A2 (human CCNA2), which is a CDK regulatory subunit that binds human CDK2 and human CDC2 to promote cell cycle G1/S and G2/M phase transition F08F3.1 F08F3.1 Protein of unknown function F08F3.2 F08F3.2 Member of the phospholipid and glycerol acyltransferase family, has low similarity to mitochondrial glycerol-3-phosphate acyltransferase (mouse Gpam), which catalyzes the first step in triacylglycerol and phospholipid biosynthesis glycerol-3-phosphate acyltransferase F08F3.3 rhr-1;F08F3.3 Member of the ammonium transporter family, has moderate similarity to rhesus blood group-associated glycoprotein (human RHAG), which is a component of the Rh antigen that plays a role in the antigen transport to the cell surface blood group RH(D) polypeptide; rhr-1 encodes an ortholog of human Rhesus blood-group associated glycoprotein (RHAG; OMIM:180297, mutated in chronic hemolytic anemia), a member of the ammonium transporter family, and affects general levels of mRNA transcripts, and embryonic viability in a large-scale RNAi screen. F08F3.4 F08F3.4 Protein of unknown function F08F3.6 F08F3.6 Protein containing an F-box domain, which serve as a link between a target protein and a ubiquitin-conjugating enzyme, has moderate similarity to uncharacterized C. elegans T10C6.10 This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins. F08F3.7 F08F3.7 Member of the cytochrome P450 family, has low similarity to cytochrome P450 subfamily 2J polypeptide 2 (human CYP2J2), which is an arachidonic acid epoxygenase cytochrome P450; ccp-14A5 encodes a member of the cytochrome P450 family. F08F3.8 F08F3.8 Protein with moderate similarity to C. elegans T20H9.6 gene product F08F3.9 F08F3.9 Protein of unknown function, putative paralog of C. elegans Y39E4B.K and C. elegans R05F9.11 F08F8.1 F08F8.1 Putative ortholog of C. elegans F08F8.5 gene product F08F8.10 F08F8.10 Protein with moderate similarity to C. elegans F08F8.9 gene product F08F8.2 F08F8.2 Member of the hydroxymethylglutaryl-coenzyme A reductase family, which catalyze NADP-dependent synthesis of mevalonate, has high similarity to a region of 3-hydroxy-3-methylglutaryl-Coenzyme A reductase (human HMGCR) Hydroxymethylglutaryl-coA reductase F08F8.3 kap-1;F08F8.3 Likely a kinesin associated protein that contains an armadillo consensus motif, forms a complex with KLP-11 and OSM-3, and may have a role in signal transduction F08F8.4 eco-1;F08F8.4 Protein with weak similarity to S. cerevisiae Yfr027p, which is required to establish cohesion between sister chromatids during DNA replication F08F8.5 F08F8.5 Putative ortholog of C. elegans F08F8.1 gene product F08F8.6 F08F8.6 Protein with weak similarity to C. elegans T23E7.2 gene product F08F8.7 F08F8.7 Protein of unknown function F08F8.8 F08F8.8 Protein of unknown function F08F8.9 F08F8.9 Protein with moderate similarity to C. elegans F08F8.10 gene product F08G12.1 F08G12.1 Protein with weak similarity to C. elegans W03C9.3 (GTP-binding protein of the rab family (ras superfamily)) ras-related like protein F08G12.10 inx-2;innexin;F08G12.10;XL914 Member of the OPUS/Innexin, gap junction, protein family; strongly similar to C. elegans INX-3 innexin F08G12.2 opu-2;inx-2;F08G12.2 Protein with high similarity to human HPRP8BP, which is a U5 snRNP-specific 40 kD protein and a component of the U5 small nuclear ribonucleoprotein particle that binds to the 220 kDa component human PRPF8, contains seven WD domains (WD-40 repeat) WD domain, G-beta repeat (6 domains) F08G12.3 F08G12.3 Protein of unknown function F08G12.4 F08G12.4 Protein of unknown function vhl-1 is orthologous to the mammalian tumor suppressor gene Von Hippel-Landau syndrome (VHL; OMIM:193300), which is part of a ubiquitylation complex targetting proteins for proteasomal degradation. F08G12.5 F08G12.5 Protein containing a C3HC4 type (RING) zinc finger, which may mediate protein-protein interactions Zinc finger, C3HC4 type (RING finger) F08G12.6 F08G12.6 TcA transposase Tc1 transposase F08G12.8 F08G12.8 Protein of unknown function F08G2.1 F08G2.1 Member of the histone H2B protein family Core histones H2A, H2B, H3 and H4; his-44 encodes an H2B histone. F08G2.2 F08G2.2 Protein with very strong similarity to C. elegans HIS-16, which is involved in cell migration, DNA packaging, and the regulation of body size, member of the histone family of nucleosomal core proteins Core histones H2A, H2B, H3 and H4; his-43 encodes an H2A histone. F08G2.3 F08G2.3 Member of the histone H3 protein family Core histones H2A, H2B, H3 and H4; his-42 encodes an H3 histone. F08G2.4 F08G2.4;2O123 Protein of unknown function F08G2.5 F08G2.5 Protein of unknown function F08G2.6 F08G2.6 Protein of unknown function F08G2.7 F08G2.7 Protein of unknown function, has moderate similarity to C. elegans C17E7.4 F08G2.8 F08G2.8 Protein of unknown function F08G5.1 F08G5.1 Protein of unknown function F08G5.2 F08G5.2 Protein of unknown function, has moderate similarity to uncharacterized C. elegans C01C10.3 F08G5.3 F08G5.3 Protein of unknown function F08G5.4 F08G5.4 Protein containing two collagen triple helix repeats, which are found in some extracellular proteins, and a nematode cuticle collagen N-terminal domain, has a region of high similarity to a region of C. elegans BLI-1 collagen F08G5.5 F08G5.5 Protein that shares a region of strong similarity with UDP glycosyltransferases, member of the C-type lectin family UDP-glucuronyltransferase like F08G5.6 F08G5.6 Member of an uncharacterized protein family F08H9.1 coh-3;F08H9.1 Protein of uknown function, has strong similarity to uncharacterized C. elegans Y45G5AM.8 coh-3 encodes a member of the Rad21/Rec8-like family of cohesion proteins that is expressed in the germline; an effect on embryonic viability has been reported based on some RNAi screens, but has not been demonstrated in others. F08H9.2 F08H9.2 Protein of unknown function F08H9.3 F08H9.3 Protein with high similarity to C. elegans F08H9.4, which is involved in the heat shock response, member of the Hsp20 or alpha crystallin family heat shock protein; F08H9.3 encodes a heat shock protein (HSP) of the HSP16 class; unlike most HSP16s in C. elegans, it is specifically expressed in a particular tissue (the larval pharynx and the anterior adult pharynx), and its expression is not strongly induced by heat shock; however, F08H9.3 expression is increased by heat shock (with adult expression in the full pharynx) and probably aids heat shock resistance, since F08H9.3(RNAi) animals have sensitivity to heat shock that is sporadically higher than normal; in general, HSP16 proteins are thought to act as passive ligands for unfolded proteins that keep them safe from aggregation until the proteins can be refolded by a large (ATP-consuming) HSP. F08H9.4 F08H9.4 Protein with high similarity to C. elegans HSP-16, which is involved in the heat shock response, member of the Hsp20 or alpha crystallin family heat shock protein; F08H9.4 encodes a heat shock protein (HSP) of the HSP16 class; unlike most HSP16s in C. elegans, it is specifically expressed in a particular tissue (the excretory canal and ventral nerve-cord neurons), and its expression is only mildly induced by heat shock; however, F08H9.4 expression is increased by heat shock, is induced in a new tissue type (intestine) by heat shock, and probably aids heat shock resistance, since F08H9.4(RNAi) animals die as embryos in heat shock at a higher rate than normal; in general, HSP16 proteins are thought to act as passive ligands for unfolded proteins that keep them safe from aggregation until the proteins can be refolded by a large (ATP-consuming) HSP. F08H9.5 F08H9.5 Member of the C-type lectin domain protein family C-type lectin domain F08H9.6 F08H9.6 Member of the C-type lectin domain protein family C-type lectin domain F08H9.7 F08H9.7 Member of the C-type lectin domain protein family C-type lectin domain F08H9.8 F08H9.8 Member of the C-type lectin domain protein family C-type lectin domain F08H9.9 F08H9.9 Protein containing two CUB domains and a C-type lectin domain, has a region of low similarity to a region of cubilin (intrinsic factor-cobalamin receptor, human CUBN), which mediates HDL endocytosis and is associated with hereditary megaloblastic anemia 1 F09A5.1 F09A5.1 Member of the major facilitator superfamily (MFS) protein family tetracycline resistance like protein F09A5.2 F09A5.2 Protein containing three protein kinase domains, has a region of low similarity to a region of a tyrosine protein kinase (C. elegans EGL-15) tyrosine-protein kinase F09A5.3 F09A5.3 Protein of unknown function F09A5.4 F09A5.4 Protein of unknown function, has a region of low similarity to S. pombe Mob1p, which is an essential protein involved in cytokinesis and septum formation F09B12.1 F09B12.1 Protein with moderate similarity to C. elegans Y43D4A.F gene product F09B12.2 F09B12.2 Protein containing a DHHC-type zinc finger (NEW1) domain F09B12.3 F09B12.3 Protein of unknown function, has moderate similarity to uncharacterized C. elegans Y37D8A.2 F09B12.4 F09B12.4 Protein of unknown function F09B12.5 F09B12.5 Protein containing three low-density lipoprotein (LDL) receptor class A domains, has a region of low similarity to a region of very low density lipoprotein receptor (human VLDLR), which acts in metabolism of liproteins and is linked to Alzheimer disease Low-density lipoprotein receptor domain class A (2 domains) F09B9.1 F09B9.1 Member of the uncharacterized protein family UPF0063, has high similarity to uncharacterized C. elegans F52F10.4 F09B9.2 unc-115;F09B9.2 Putative actin-binding protein required for proper axon guidance LIM domains; unc-115 encodes a protein that binds actin filaments and that is required for RAS signalling and UNC-40/netrin activity during axon pathfinding. F09B9.3 ERD2;F09B9.3 Protein with high similarity to KDEL endoplasmic reticulum protein retention receptor 1 (human KDELR1), which is involved in retention of proteins in the endoplasmic reticulum, member of the endoplasmic reticulum lumen protein retaining receptor family ER lumen protein retaining receptor; erd-2 encodes a protein with homology to human ER lumen protein retaining receptor 1. F09B9.4 F09B9.4 Protein with weak similarity to S. cerevisiae YDL099W F09C11.1 F09C11.1 Protein of unknown function F09C12.1 gbr-6;F09C12.1 Protein containing neurotransmitter-gated ion-channel ligand binding and transmembrane domains, has low similarity to alpha 3 subunit of the inhibitory glycine receptor (rat Glra3), which may play a role in neuronal differentiation and excitability Glycine receptor alpha chain; ggr-3 encodes a predicted member of the GABA/ glycine receptor family of ligand-gated chloride channels; expressed in the AVA, AVB, SMDD, DVA, SIAD, and in some other neurons of the nerve ring. F09C12.2 F09C12.2 Protein containing a protein kinase domain, has a region of high similarity to S. pombe Spk1p, which is a mitogen-activated protein kinase acting in the mating and sporulation pathways Ser/Thr protein kinase F09C12.6 F09C12.6 Protein of unknown function, has moderate similarity to C. elegans C30B5.7 F09C12.7 F09C12.7 Protein of unknown function, has very strong similarity to a region of C. elegans MSP-10 msp-74 encodes a protein that belongs to a family of proteins called the Major Sperm Proteins (MSPs) that is conserved in nematodes; this family consists of closely related, small, basic proteins that make up 15% of sperm protein; this multigene family consists of over fifty genes, including many pseudogenes; MSPs are involved in both extracellular signaling and cytoskeletal functions during reproduction-MSP antagonizes Eph/ephrin signaling, in part, by binding VAB-1 Eph receptor tyrosine kinase on oocytes and sheath cells to promote oocyte maturation and MAPK activation; MSPs assemble into fibrous networks that drive movement of the C. elegans sperm; msp genes are expressed only in late primary spermatocytes. F09C3.1 F09C3.1 Protein containing two IQ calmodulin-binding domains, has weak similarity to IQ motif containing GTPase activating protein 2 (human IQGAP2), which inhibits GTPase activity of human CDC42 and RAC1 and may bind actin and help regulate cell shape ras GTPase-activating protein like; pes-7 encodes an ortholog of the vertebrate IQGAP proteins, actin- and CLIP-170-binding proteins that serve as effectors for the Rho family GTPases Rac1 and Cdc42; IQGAP's alpha-actinin domain is related distantly to alpha-actinin domains in calponin, transgelin (SM22 alpha), and the proto-oncogene Vav; pes-7 was identified in promoter-trapping screens and by homology, is predicted to function as a key regulator of cytoskeletal organization in migrating cells and as a regulator of cadherin-mediated cell-cell adhesion; however, PES-7 has no obvious function in mass RNAi assays; a pes-7 reporter is first expressed in the ventral nerve cord of the elongating embryo and in later stages of development is also expressed in all major ganglia, the vulva, and in the spermathecal valves; in the ventral nerve cord, pes-7 expression is detected in nuclei as well as in cell bodies and neural processes. F09C3.2 F09C3.2 Member of the haloacid dehalogenase or epoxide hydrolase family haloacid dehalogenase-like hydrolase; This gene encodes a protein predicted by Eisenberg and coworkers, with 52% accuracy, to be mitochondrial. F09C3.3 F09C3.3 Protein containing an F-box domain, which serve as a link between a target protein and a ubiquitin-conjugating enzyme, has high similarity to uncharacterized C. elegans F09C3.5 This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins; its encoded protein also contains a Pfam-B45 motif of presently unknown function. F09C3.4 F09C3.4 Protein containing a DUF38 domain of unknown function and an F-box domain, which serve as a link between a target protein and a ubiquitin-conjugating enzyme, has high similarity to uncharacterized C. elegans T06E6.13 This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins; this gene's encoded protein also contains an FTH/DUF38 motif, which may also mediate protein-protein interaction. F09C3.5 F09C3.5 Protein of unknown function, putative paralog of C. elegans F09C3.3 F09C3.6 F09C3.6 Putative paralog of C. elegans Y58G8A.2 reverse transcriptase F09C6.1 F09C6.1 Protein of unknown function, has strong similarity to C. elegans F40H7.4 F09C6.10 F09C6.10 Protein with strong similarity to C. elegans D1086.6 gene product F09C6.2 F09C6.2 Protein containing a DUF38 domain of unknown function and an F-box domain, which serve as a link between a target protein and a ubiquitin-conjugating enzyme, has high similarity to uncharacterized C. elegans F09C6.6 This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins; this gene's encoded protein also contains an FTH/DUF38 motif, which may also mediate protein-protein interaction. F09C6.3 F09C6.3 Protein of unknown function F09C6.4 F09C6.4 Member of the serpin family of serine protease inhibitors, has low similarity to human SERPINB8, which is an inhibitor of furin (human PACE), thrombin (human F2), factor Xa (human F10) and other trypsin-like and chymotrypsin-like proteinases Serpins (serine protease inhibitors) (2 domains) F09C6.5 F09C6.5 Member of the serpin family of serine protease inhibitors, has low similarity to human SERPINB8, which is an inhibitor of furin (human PACE), thrombin (human F2), factor Xa (human F10) and other trypsin-like and chymotrypsin-like proteinases Serpins (serine protease inhibitors) (2 domains) F09C6.6 F09C6.6 Protein containing a DUF38 domain of unknown function and an F-box domain, which serve as a link between a target protein and a ubiquitin-conjugating enzyme, has high similarity to uncharacterized C. elegans F09C6.2 This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins; this gene's encoded protein also contains an FTH/DUF38 motif, which may also mediate protein-protein interaction. F09C6.7 F09C6.7 G protein-coupled receptor, member of a subfamily with SRD proteins which are expressed in chemosensory neurons, no homolog found in human or D. melanogaster F09C6.8 F09C6.8 Protein containing a nuclear hormone receptor ligand-binding domain and C4-type zinc finger domain, which bind DNA and may be involved in regulation of transcription, has low similarity to hepatocyte nuclear factor 4 alpha (human HNF4A) Zinc finger, C4 type (two domains) F09C6.9 F09C6.9 Protein containing a nuclear hormone receptor C4-type zinc finger domain, which may be involved in regulation of transcription, and a nuclear hormone receptor ligand-binding domain, has low similarity to retinoic acid receptor gamma (mouse Rarg) nuclear hormone receptor F09C8.1 F09C8.1 Member of the lipase or acylhydrolase family, has moderate similarity to a region of intestinal phospholipase B-lipase (rat PLB-LIP), which has phospholipase A2, lysophospholipase, and triacylglycerol lipase activity phospholipase precursor F09C8.2 F09C8.2 Protein of unknown function F09D1.1 F09D1.1 Protein containing a ubiquitin carboxyl-terminal hydrolases family 2 domain and a Zn-finger in ubiquitin-hydrolases and other proteins domain, has low similarity to S. cerevisiae Sad1p, which is required for pre-mRNA splicing and for snRNP assembly ubiquitin protease F09D12.1 grd-10;F09D12.1 Protein of unknown function, has strong similarity to C. elegans GRD-5 grd-10 encodes a protein that contains a novel Ground domain that is closely related to GRD-5. F09D12.2 F09D12.2 Member of the M13 peptidase family of zinc metalloproteases, has high similarity to uncharacterized C. elegans Y19D10B.6 F09D12.2 encodes a neprilysin; neprilysins are thermolysin-like zinc metallopeptidases, found on the outer surface of animal cells, that negatively regulate small signalling peptides (e.g., enkephalin, tachykinin, insulin, and natriuretic peptides) by cleaving them; F09D12.2 has no clear orthologs in other organisms. F09E10.1 F09E10.1 Protein of unknown function F09E10.3 F09E10.3 Protein with high similarity to mouse H2-Ke6, which is a 17-beta dehydroxysteroid dehydrogenase that is involved in androgen or estrogen metabolism, member of the short-chain dehydrogenase-reductase family, which are NAD- or NADP-dependent oxidoreductases short-chain alcohol dehydrogenase; dhs-25 encodes a short-chain dehydrogenase predicted to be mitochondrial. F09E10.5 F09E10.5 Protein of unknown function F09E10.6 F09E10.6 Protein with weak similarity to C. elegans F55C12.7 gene product F09E10.7 F09E10.7 Protein of unknown function, has weak similarity to C. elegans R102.1 F09E10.8 F09E10.8 Putative paralog of C. elegans K08E3.3, has similarity to human Hs.73999, CDC42-interacting protein 4 F09E5.1 pkc-3;F09E5.1 Serine/threonine protein kinase; has strong similarity to human, D. melanogaster, and S. cerevisiae atypical protein kinase C isoforms; important for establishment of embryonic polarity Protein kinase C F09E5.10 F09E5.10 Protein of unknown function, has very strong similarity to uncharacterized C. elegans Y43F4B.2, which is predicted to be a ubiquitin carboxyl-terminal hydrolase F09E5.11 F09E5.11 Protein of unknown function F09E5.12 F09E5.12 Protein of unknown function F09E5.13 agt-2;F09E5.13 O6-alkylguanine DNA-alkyltransferase, implicated in alkyl transfer-mediated DNA repair agt-2 encodes a paralog of the DNA repair enzyme O6-Alkylguanine DNA-alkyltransferase (AGT); AGT-2 has AGT biochemical activity and is expressed at all developmental stages. F09E5.2 F09E5.2 Putative member of the thioredoxin peroxidase/thiol-specific antioxidant AHPC/TSA protein F09E5.3 F09E5.3 Member of deoxyribose-phosphate aldolase, which may be involved in nucleotide metabolism, has high similarity to uncharacterized human LOC51071 Deoxyribose-phosphate aldolase F09E5.4 F09E5.4 Protein with weak similarity to C. elegans T09D3.5 gene product 7TM chemoreceptor, srg family F09E5.5 F09E5.5 Protein with weak similarity to tumor necrosis factor alpha-induced protein 2 (human TNFAIP2), which plays a role in myeloid development and is a target gene of promyelocytic leukemia retinoic acid receptor in acute promyelocytic leukemia F09E5.7 F09E5.7 Protein of unknown function F09E5.8 F09E5.8 Member of the uncharacterized protein family UPF0001, has high similarity to uncharacterized proline synthetase co-transcribed (mouse Prosc) F09E5.9 F09E5.9 Protein of unknown function, putative paralog of C. elegans F09E5.10 F09E8.1 F09E8.1 Protein containing a DX module domain F09E8.2 F09E8.2;msh-5 Protein of unknown function, has a region of low similarity to a region of very low density lipoprotein receptor (human VLDLR), which mediates transport and metabolism of liproteins F09E8.3 msh-5;F09E8.3 Protein required for meiotic recombination and chiasma formation, member of the MutS family of proteins Yeast DNA mismatch repair protein MSH5 like; msh-5 encodes a germline-specific homolog of the yeast and mammalian DNA mismatch repair protein MSH5 (MutS-family) that is required for crossing over and chiasma formation during Caenorhabditis elegans meiosis; inactivation of both rad-51 and msh-5 induces chromosome fragmentation, not seen with inactivation of either gene alone. F09E8.5 F09E8.5 Member of the SCP-like extracellular protein family, has low similarity to specific granule protein 28kDa (human SGP28), which is a glycoprotein that is widely expressed and localizes to specific granules in neutrophils testis-specific protein TPX-1 like F09E8.6 F09E8.6 Member of the astacin (M12A) family of metalloproteases, has a region of moderate similarity to a region of bone morphogenetic protein 1 (human BMP1), which is a metalloprotease that cleavages C-propeptides of procollagens I, II, and III zinc metalloprotease F09E8.7 lev-1;acr-1;F09E8.7 Putative "non-alpha" subunit of a nicotine acetylcholine receptor acetylcholine receptor; lev-1 encodes an alpha subunit of nicotinic acetylcholine receptor (nAChR) which, when mutated, confers resistance to levamisole; LEV-1 is required for completely normal locomotion, and forms a cation channel when coexpressed with UNC-38 or UNC-63 and UNC-29; LEV-1 falls into the 'UNC-29' class of nAChR subunits, which includes UNC-29, ACR-2, and ACR-3. F09F3.1 F09F3.1 Member of the G protein-coupled receptor protein family G-protein coupled receptor F09F3.10 F09F3.10 Protein containing a nuclear hormone receptor C4-type zinc finger domain, which bind DNA, and a nuclear hormone receptor ligand-binding domain, has low similarity to nuclear receptor subfamily 2 group F member 6 (rat Rn.25840) Ligand-binding domain of nuclear hormone receptors, Zinc finger, C4 type (two domains) F09F3.11 F09F3.11 Protein of unknown function, has moderate similarity to uncharacterized C. elegans F09F3.13 7TM receptor, srx family F09F3.12 F09F3.12 Member of the G protein-coupled receptor protein family 7TM receptor, srx family F09F3.13 F09F3.13 Protein of unknown function, has moderate similarity to uncharacterized C. elegans F09F3.12 7TM receptor, srx family F09F3.2 F09F3.2 Member of the G protein-coupled receptor protein family 7TM receptor, srx family F09F3.3 F09F3.3 Protein of unknown function, has high similarity to uncharacterized C. elegans F09F3.2 F09F3.4 F09F3.4 Member of the G protein-coupled receptor protein family 7TM receptor, srx family F09F3.5 F09F3.5 Member of the animal heme peroxidase family, has low similarity to myeloperoxidase (mouse Mpo), which mediates neutrophil and monocyte microbicidal activity and may have a role in atherosclerosis peroxidase like F09F3.6 F09F3.6 Member of the transthyretin-like family, has high similarity to uncharacterized C. elegans T04H1.3 Transthyretin-like family F09F3.7 F09F3.7 Protein of unknown function, has low similarity to uncharacterized C. elegans F09F3.12 7TM receptor, srx family F09F3.9 F09F3.9 Member of the choline or carnitine o-acyltransferase family, has low similarity to liver carnitine palmitoyltransferase I (rat Cpt1a), which acts in long-chain fatty acid beta-oxidation and influences energy production, cell signaling and apoptosis carnitine palmitoyltransferase like F09F7.1 F09F7.1 Protein of unknown function F09F7.2 mlc-3;F09F7.2 Protein with high similarity to myosin light chain 1 (alkali, human MLC1), which is a structural protein of myosin that may regulate the molecular motor activity for muscle contraction by modulating actin binding, contains two EF hand domains F09F7.3 F09F7.3 Protein with high similarity to the RNA polymerase III second-largest subunit (C128, S. cerevisiae Ret1p), member of the RNA polymerases beta subunit family, which are shared among all three types of eukaryotic RNA polymerases F09F7.4 F09F7.4 Protein with high similarity to beta-hydroxyisobutyryl-coenzyme A hydrolase (human HIBCH), which acts in valine catabolism by hydrolyzing 3-hydroxyisobutyryl CoA, member of the enoyl-CoA hydratase or isomerase family Enoyl-CoA hydratase F09F7.5 F09F7.5 Protein of unknown function F09F7.6 F09F7.6 Protein of unknown function F09F7.7 F09F7.7 Protein of unknown function, has low similarity to uncharacterized human FLJ20013 F09F7.8 F09F7.8 Protein of unknown function, has weak similarity to C. elegans F35C5.10 F09F9.1 F09F9.1 Protein of unknown function F09F9.2 F09F9.2 Protein of unknown function, has weak similarity to C. elegans F16F9.2 F09F9.3 F09F9.3 Protein of unknown function F09F9.4 F09F9.4 Protein containing a type 1 thrombospondin domain, has a region of high similarity to a region of thrombospondin 2 (human THBS2), which is an adhesive molecule that binds heparin and plays roles in cell adhesion and inhibition of angiogenesis Type I thrombospondin (TSP) repeats F09G2.1 F09G2.1 Protein containing a protein kinase domain, has a region of low similarity to a region of a tyrosine protein kinase (C. elegans EGL-15) tyrosine protein kinase F09G2.2 F09G2.2 Protein of unknown function F09G2.3 F09G2.3 Member of the phosphate transporter family, has low similarity to solute carrier family 20 member 1 (human SLC20A1), which is a high-affinity sodium-inorganic phosphate cotransporter that plays a role in phosphate transport and metabolism permease F09G2.4 F09G2.4 Protein with moderate similarity to cleavage and polyadenylation specificity factor 2 (mouse Cpsf2), which is a subunit of the general polyadenylation factor and a poly(A)-binding protein that is likely to play a role in mRNA polyadenylation F09G2.5 F09G2.5 Protein containing neurotransmitter-gated ion-channel ligand binding and transmembrane domains, has low similarity to alpha 3 subunit of the inhibitory glycine receptor (rat Glra3), which may play a role in neuronal differentiation and excitability ion channel protein F09G2.6 F09G2.6 Protein containing two UDP-glucoronosyl and UDP-glucosyl transferase domains, has low similarity to UDP glycosyltransferase 1 family polypeptide A1 (human UGT1A), which acts in bilirubin conjugation and has a role in Gilbert and Crigler-Najjar syndromes F09G2.7 F09G2.7 Member of the 7-transmembrane chemoreceptor family of G protein-coupled receptors (GPCR), has high similarity to uncharacterized C. elegans C44C3.9 7TM chemoreceptor, srh family F09G2.8 F09G2.8 Protein containing two phospholipase D active site motifs, has moderate similarity to uncharacterized phospholipase D3 (mouse Pld3), which may play a role in signal transduction and neurogenesis F09G2.9 F09G2.9 Protein of unknown function, has weak similarity to human nuclear autoantigenic sperm protein NASP, has weak similarity to S. cerevisiae Chs5p (required for chitin synthase III activity) F09G8.1 F09G8.1 Protein of unknown function F09G8.2 YLS2;F09G8.2 Protein with strong similarity to H. sapiens DNase II, a lysosomal deoxyribonuclease II F09G8.3 F09G8.3 Protein with moderate similarity to the amino terminus of H. sapiens NPC1, a protein involved in Niemann-Pick disease F09G8.4 npc-2;F09G8.4 Member of the patched family, which are transmembrane receptors, has low similarity to C. elegans NPC-1, which functions in cholesterol metabolism and possibly general vesicular trafficking ncr-2 encodes a homolog of human NPC1, which when mutated leads to Niemann-Pick disease, type C (OMIM:257220). F09G8.5 F09G8.5 Protein containing leucine rich repeats, which mediate protein-protein interactions F09G8.6 F09G8.6 Protein containing two collagen triple helix repeats, which are found in some extracellular proteins and nematode cuticle collagen N-terminal domain, has high similarity to a region of C. elegans BLI-1 Cuticle collagen F09G8.7 F09G8.7 Protein of unknown function F09G8.8 F09G8.8 Member of the lectin C-type domain containing protein family F09G8.9 F09G8.9 Protein of unknown function, has moderate similarity to C. elegans F09G8.8 F10A3.1 F10A3.1 Protein of unknown function, has high similarity to uncharacterized C. elegans F44G3.10 F10A3.1 encodes a claudin homolog that may be required for normal cohesion of apical junctions in epithelia; F10A3.1 is worm-specific, with obvious homologs only in C. elegans; F10A3.1 has no obvious function in mass RNAi assays; claudins are integral membrane proteins with four transmembrane sequences that are found in mammalian tight junctions (TJs), induce TJs when transgenically expressed in cells normally lacking them, and can mediate the specific conductance of of specific ions (e.g., magnesium or calcium) through TJs while blocking the flow of water. F10A3.11 F10A3.11 Protein of unknown function, has low similarity to uncharacterized C. elegans T07D3.2 F10A3.12 F10A3.12 Member of the 7-transmembrane chemoreceptor family of G protein-coupled receptors (GPCR), has low similarity to C. elegans ODR-10, which is a G protein-coupled receptor involved in odorant response F10A3.13 F10A3.13 Member of the 7-transmembrane chemoreceptor family of G protein-coupled receptors (GPCR), has low similarity to C. elegans ODR-10, which is a G protein-coupled receptor involved in odorant response F10A3.15 F10A3.15 Member of the 7-transmembrane chemoreceptor family of G protein-coupled receptors (GPCR), has weak similarity to C. elegans ODR-10, which is a G protein-coupled receptor involved in odorant response F10A3.2 F10A3.2 Protein containing a DUF38 domain of unknown function and an F-box domain, which serve as a link between a target protein and a ubiquitin-conjugating enzyme, has low similarity to C. elegans FOG-2 This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins; this gene's encoded protein also contains an FTH/DUF38 motif, which may also mediate protein-protein interaction. F10A3.3 F10A3.3 Protein containing an F-box domain, which serve as a link between a target protein and a ubiquitin-conjugating enzyme This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins. F10A3.5 F10A3.5 Member of the 7-transmembrane chemoreceptor family of G protein-coupled receptors (GPCR), has low similarity to C. elegans ODR-10, which is a G protein-coupled receptor involved in odorant response F10A3.6 F10A3.6 Member of the 7-transmembrane chemoreceptor family of G protein-coupled receptors (GPCR), has low similarity to C. elegans ODR-10, which is a G protein-coupled receptor involved in odorant response F10A3.7 F10A3.7 Member of the 7-transmembrane chemoreceptor family of G protein-coupled receptors (GPCR), has low similarity to a region of C. elegans ODR-10, which is a G protein-coupled receptor involved in odorant response F10A3.8 F10A3.8 Member of the 7-transmembrane chemoreceptor family of G protein-coupled receptors (GPCR), has low similarity to C. elegans ODR-10, which is a G protein-coupled receptor involved in odorant response F10A3.9 F10A3.9 Member of the 7-transmembrane chemoreceptor family of G protein-coupled receptors (GPCR), has high similarity to uncharacterized C. elegans C05E4.13 F10B5.1 F10B5.1 Protein with high similarity to human RPL10, which is a structural ribosomal protein, member of the ribosomal L10e family, which are part of the large ribosomal subunit ribosomal protein L10 (QM protein); rpl-10 encodes a large ribosomal subunit L10 protein required in mass RNAi assays for embryonic viability, fertility, normally rapid growth, and normal body coloration; the rpl-10 transcription unit has a nonsense transcript that is up-regulated in vivo by smg[-] mutations, indicating that rpl-10 is a natural substrate for SMG-mediated nonsense suppresssion; several other natural mRNA substrates of SMG suppression (e.g., rpl-3, rpl-7, rpl-12) have protein products that are involved in translation. F10B5.2 F10B5.2 Protein of unknown function F10B5.3 F10B5.3 Protein containing three C2H2 type zinc finger domains, which bind nucleic acids Zinc finger, C2H2 type F10B5.4 tub-1;F10B5.4 Member of the Tub family, has moderate similarity to tubby (mouse Tub), which is a transcription factor that is associated with obesity and sensory deficits and may play roles in the insulin receptor signaling and G protein signaling pathways Tub family protein tub-1; tub-1 encodes a tubby homolog that affects fat storage in C. elegans and may function in a parallel pathway with kat-1 to affect lipid accumulation based on genetic analysis; expressed primarily in sensory neurons. F10B5.5 F10B5.5 Member of the ATPase family associated with various cellular activities, has moderate similarity to thyroid hormone receptor-interacting protein 13 (human TRIP13), which is a transcription cofactor that binds the thyroid hormone receptor ATP binding protein F10B5.6 emb-27;cdc16;APC6;F10B5.6 Predicted component of the anaphase-promoting complex or cyclosome (APC/C), required for separation of homologous chromosomes during meiosis I cell division control protein; emb-27 encodes a tetratricopeptide repeat (TPR)-containing protein that is the C. elegans ortholog of the anaphase-promoting complex (APC) subunit APC-6 (CDC16); required maternally and paternally, EMB-27 activity is essential for proper execution of the metaphase-to-anaphase transition during meiosis (both oogenesis and spermatogenesis) and mitosis (during germline proliferation); EMB-27 activity is also critical for embryonic anterior-posterior (A-P) axis formation, production of the secreted eggshell, and normal vulval development; in establishing the embryonic A-P axis, EMB-27 likely acts upstream of the separin protease to ensure proper localization of PAR-3 and PAR-2 to the anterior and posterior cortices, respectively. F10B5.7 rrf-3;F10B5.7 Protein of unknown function, has a region of low similarity to C. elegans EGO-1, which is necessary for germ-line development rrf-3 encodes an RNA-directed RNA polymerase (RdRP) homolog that inhibits somatic RNAi, and thus promotes activity of repeated genes (e.g., multicopy transgenic arrays); the effect of RRF-3 on RNAi is opposite to that of RRF-1 (which stimulates somatic RNAi), which might arise from competition by RRF-3 with RRF-1 or EGO-1 in RNAi formation; rrf-3(allele) or rrf-3(allele2) mutants are hypersensitive to somatic RNAi, and conversely suppress the activity of an integrated rol6 (su1006) transgene. F10B5.8 F10B5.8 Putative ortholog of D. melanogaster CG1972 (CG1972 gene product) F10C1.1 F10C1.1 Protein of unknown function F10C1.2 ifb-1;F10C1.2 Member of the intermediate filament family, which are components of the cytoskeleton and nuclear envelope, contains an intermediate filament tail domain, has low similarity to lamin A (human LMNA), which is associated with muscular and lipodystrophies Intermediate filament protein; ifb-1 (also known as vab-21) encodes two isoforms of an essential intermediate filament protein that is coexpressed with the essential IF proteins IFA-1, IFA-2, and IFA-3, along with IFA-4; IFB-1 is required for embryonic development and epidermal morphogenesis; IFB-1 forms heteropolymeric intermediate filaments in vitro with an equimolar mixture of IFA-1, IFA-2, or IFA-3, and binds IFA-4 in blot overlay assays; IFB-1 resides in attachment structures of epidermal cells, found in sites undergoing mechanical stress; the two isoforms are expressed in different tissues and have distinct functions, since ifb-1A(RNAi) larvae have detached muscle cells, while ifb-1B(RNAi) larvae have detached cuticle. F10C1.3 F10C1.3 Protein of unknown function F10C1.5 F10C1.5 Protein containing two DM (dsx and mab-3) DNA binding domains, has a region of high similarity to a region of C. elegans MAB-3, which is required for sex-specific production of yolk proteins and male tail development D. melanogaster doublesex protein F10C1.7 ifb-2;F10C1.7 Member of the intermediate filament family, which are components of the cytoskeleton and nuclear envelope, contains three intermediate filament tail domains, has high similarity to uncharacterized C. elegans CEL-IF-B1 Intermediate filament protein; ifb-2 encodes a nonessential intermediate filament protein; IFB-2 is predicted to function as a structural component of the cytoskeleton; IFB-2 has no obvious function in RNAi assays. F10C2.2 kup-1;kup1;F10C2.2 Protein of unknown function KUP-1 protein; kup-1 encodes a novel protein that is conserved in C. briggsae, but contains no other known homologs; kup-1 is the upstream gene in an operon with pkc-1, which encodes two protein kinase C isoforms of the nPKC isotype; the polycistronic kup-1/pkc-1 mRNA is detected at low levels in embryos and larvae, but its expression greatly increases in adults; as loss of kup-1 activity via large-scale RNAi screens does not result in any obvious abnormalities, the precise role of kup-1 in C. elegans development and/or behavior is not yet known. F10C2.3 F10C2.3 Member of uncharacterized DUF229 family, has low similarity to uncharacterized C. elegans F15H10.7 F10C2.4 F10C2.4 Protein with high similarity to rat Pold1, which is the catalytic subunit of DNA polymerase delta 1 and has an essential role in DNA replication, member of the DNA-directed DNA polymerase B family, contains a DNA polymerase B exonuclease domain DNA polymerase family B; F10C2.4 encodes a homolog of the DNA polymerase delta complex subunit A that is required in embryos for the normal timing of embryonic cell divisions (much as DIV-1 is) and, also, for normal chromosome segregation (probably because of defective DNA replication). F10C2.5 F10C2.5 Member of the glycosyl hydrolase 47 family of alpha-mannosidases, which hydrolyze terminal mannose residues, has a region of low similarity to a region of S. cerevisiae Mnl1p, which is involved in endoplasmic reticulum-associated glycoprotein degradation mannosyl-oligosaccharide alpha-1,2-mannosidase F10C2.6 F10C2.6 Protein containing two class II asparagine, aspartic acid and lysine tRNA synthetase (D, K and N) domains, has a region of low similarity to a region of aspartyl-tRNA synthetase (human DARS), which aminoacylates tRNA with aspartate for protein synthesis aspartyl-tRNA synthetase; drs-2 encodes a putative aspartyl-tRNA synthetase. F10C2.7 F10C2.7 Protein with similarity to human and D. melanogaster sodium-dependent inorganic phosphate cotransporters F10C5.1 mat-3;apc-8;cdc-23;F10C5.1 Predicted component of the anaphase-promoting complex or cyclosome (APC/C), required for separation of homologous chromosomes during meiosis I (610391) x F10C5.2 F10C5.2 Protein of unknown function F10D11.1 sod-2;F10D11.1 Manganese superoxide dismutase superoxide dismutase; sod-2 encodes a iron/manganese superoxide dismutase, predicted to be mitochondrial, that might defend against oxidative stress and promote normal lifespan; sod-2 mRNA levels are diminished by mutation of daf-16, and heterologously expressed SOD-2 in E. coli protects against methyl viologen-induced oxidative stress. F10D11.2 F10D11.2 Protein of unknown function F10D11.3 F10D11.3 Protein of unknown function F10D11.4 F10D11.4 Protein of unknown function, has high similarity to uncharacterized C. elegans T15H9.5 F10D11.5 F10D11.5 Protein of unknown function, has moderate similarity to uncharacterized C. elegans T15H9.4 F10D11.6 F10D11.6 Protein containing lipopolysaccharide-binding protein, bactericidal permeability-increasing protein, or cholesteryl ester transfer protein N-terminal and C-terminal domains, has weak similarity to uncharacterized C. elegans F44A2.3 F10D2.1 F10D2.1 Member of the 7-transmembrane chemoreceptor family of G protein-coupled receptors (GPCR), has low similarity to C. elegans ODR-10, which is a G protein-coupled receptor involved in odorant response 7TM chemoreceptor, str family F10D2.10 F10D2.10 Protein of unknown function, has high similarity to uncharacterized C. elegans Y73C8B.3 F10D2.11 F10D2.11 Protein containing two UDP-glucoronosyl and UDP-glucosyl transferase domains, has low similarity to UDP-glucuronosyltransferase 1 A7 (rat Ugt1a7), which converts hydrophobic xenobiotic and endobiotic compounds to hydrophilic compounds glucuronosyltransferase F10D2.2 F10D2.2 Protein containing a UDP-glucoronosyl and UDP-glucosyl transferase domain, has low similarity to UDP glycosyltransferase 2 polypeptide B10 (human UGT2B10), which is a UDP-glucuronosyltransferase for which no substrate has been found glucuronosyltransferase F10D2.3 F10D2.3 Member of the C. elegans Sre G protein-coupled chemoreceptor family, which are putative chemosensory receptors, has moderate similarity to uncharacterized C. elegans T07H8.7 F10D2.4 F10D2.4 Protein with high similarity to C. elegans ODR-10, which is a G protein-coupled receptor involved in odorant response, member of the 7-transmembrane chemoreceptor family of G protein-coupled receptors (GPCR) 7TM chemoreceptor, str family F10D2.5 F10D2.5 Protein containing two UDP-glucoronosyl and UDP-glucosyl transferase domains, has low similarity to UDP-glucuronosyltransferase 8 (UDP-galactose ceramide galactosyltransferase, rat Ugt8), which acts in the formation of galactosylceramide glucuronosyltransferase F10D2.6 F10D2.6 Protein containing two UDP-glucoronosyl and UDP-glucosyl transferase domains, has weak similarity to UDP glycosyltransferase 1 family polypeptide A6 (mouse Ugt1a6), which catalyzes the glucoronidation of small planar phenolic molecules glucuronosyltransferase F10D2.7 F10D2.7 Protein containing a UDP-glucoronosyl and UDP-glucosyl transferase domain, has low similarity to UDP-glucuronosyltransferase 2B family member 5 (mouse Ugt2b5), which conjugates lipophilic aglycon substrates with glucuronic acid glucuronosyltransferase F10D2.8 F10D2.8 Protein containing a UDP-glucoronosyl and UDP-glucosyl transferase domain, has low similarity to UDP glycosyltransferase 1 family polypeptide A1 (human UGT1A), which acts in bilirubin conjugation and plays a role in Gilbert and Crigler-Najjar syndromes F10D2.9 fat-7;F10D2.9 Likely a stearoyl-CoA delta-9 fatty acid desaturase, specific for long chain (16:0 - 18:0) fatty acids stearoyl-CoA desaturase; fat-7 encodes an essential delta-9 fatty acid desaturase that is required for the synthesis of monounsaturated fatty acids; fat-7 can substitute for the functions of the other two fatty acid desaturases, fat-5 and fat-6; RNA interference has shown that fat-7 is required for viability and normal growth. F10D7.1 F10D7.1 G protein-coupled receptor with similarity to human bombesin-like receptor F10D7.2 F10D7.2 Member of the sugar (and other) transporter family, has moderate similarity to uncharacterized tetracycline transporter-like protein (human TETRAN), which may be involved in tetracycline transport calcium alpha subunit; tetracycline resistance; This gene encodes a protein predicted by Eisenberg and coworkers, with 52% accuracy, to be mitochondrial. F10D7.3 F10D7.3 Protein containing a glutaredoxin domain, has a region of low similarity to a region of glutaredoxin 2 (human GLRX2), which is a glutaredoxin that reduces GSH based mixed disulfides and acts as an electron carrier glutaredoxin; This gene encodes a protein predicted by Eisenberg and coworkers, with 68% accuracy, to be mitochondrial. F10D7.4 F10D7.4 Protein of unknown function F10D7.5 F10D7.5 Protein containing three C3HC4 type (RING) zinc fingers, which may mediate protein-protein interactions, has low similarity to neuralized like (mouse Neurl), which is required for olfactory stimuli discrimination, locomotion and spermatid maturation D. melanogaster finger protein neuralized F10E7.1 F10E7.1 Protein of unknown function, has a region of low similarity to a region of C. elegans PHA-1, which is involved in pharyngeal development F10E7.10 F10E7.10 Protein of unknown function, has a region of low similarity to a region of C. elegans CUT-1, which is a cuticulin component F10E7.11 F10E7.11 Protein containing one Myb-like DNA-binding domain and one Egl-27 and MTA1 homology 2 (ELM2) domain, which may be involved in DNA or protein-protein binding, has high similarity to uncharacterized C. elegans T07F8.4 F10E7.2 F10E7.2 Protein of unknown function F10E7.3 F10E7.3 Protein with strong similarity to C. elegans C27H5.4 gene product F10E7.4 F10E7.4 Protein containing five type 1 thrombospondin domains, a kunitz or bovine pancreatic trypsin inhibitor domain and a reeler domain, has low similarity to F-spondin (rat Sponf), which is a cell adhesion molecules that promotes neurite extension F-spondin F10E7.5 F10E7.5 Protein with high similarity to 60S acidic ribosomal protein PO (human RPLP0L), which is a protein of the 60S large ribosomal subunit that may be involved in protein biosynthesis, apoptosis, and neuron differentiation, member of the ribosomal L10 family F10E7.6 F10E7.6 Protein of unknown function F10E7.7 F10E7.7 Protein with high similarity to ribosomal protein L35a (rat Rpl35a), which is a component of the 60S ribosomal subunit that binds RNA, member of the ribosomal L35Ae family 60s ribosomal protein L35A; rpl-33 encodes a large ribosomal subunit L35a protein. F10E7.8 F10E7.8 Protein of unknown function, has moderate similarity to uncharacterized human KIAA1170 F10E7.9 F10E7.9 Protein with strong similarity to a region of human and C. elegans sodium/potassium/chloride transporters bumetanide-sensitive Na-K-Cl cotransporter F10E9.1 F10E9.1 Protein of unknown function F10E9.10 F10E9.10 Protein of unknown function F10E9.11 F10E9.11 Protein of unknown function F10E9.12 F10E9.12 Protein of unknown function F10E9.2 F10E9.2 Protein of unknown function, has similarity to C. elegans Y38H8A.2 F10E9.3 F10E9.3 Protein of unknown function F10E9.4 F10E9.4 Protein of unknown function F10E9.5 F10E9.5 Protein of unknown function F10E9.6 mig-10;F10E9.6 Protein containing two pleckstrin homology (PH) domains, which mediate protein-protein and protein-lipid interactions, has low similarity to mouse Apbb1ip, which is a proline-rich protein that interacts with the neural-specific protein mouse FE65 mig-10 encodes a protein containing a pleckstrin homology domain and a proline-rich region, and is similar to the SH2-domain containing adapter proteins Grb7 and Grb10 which are involved in receptor tyrosine kinase-mediated signal transduction; MIG-10 is likely required for signal transduction during cell migration, as it is required non-cell autonomously for excretory canal development and anterior-posterior migrations of the embryonic neurons ALM, CAN, and HSN; mig-10 mutations appear to interact genetically with mutations in all three C. elegans rac genes, ced-10, mig-2, and rac-2, suggesting partial redundancy during neuronal migration and excretory canal outgrowth; MIG-10 is expressed in many embryonic cells and in four cells in the adult head. F10E9.7 F10E9.7 Protein containing a cytidine deaminase zinc-binding domain F10E9.8 F10E9.8 Putative coiled-coil protein, has weak similarity across the C-terminus to human CENPF ( centromere protein F) sas-4 encodes a predicted coiled-coil protein and centriole component recruited to the centrosome once per cell cycle at the time of organelle duplication and is required for centriole duplication and spindle assembly, levels dictate centrosome size, and also affects germ cell proliferation and locomotion; colocalizes with gamma-tubulin to centrosomes both in sperm and in the syncitial part of the gonad. F10F2.1 F10F2.1 Protein containing five WD domains (WD-40 repeat), which may mediate protein-protein interactions, and a beige or BEACH domain, has moderate similarity to neurobeachin (mouse Nbea), which binds to and recruits protein kinase A (PKA) to membranes WD domain, G-beta repeat (2 domains) F10F2.2 F10F2.2 Protein with high similarity to phosphoribosylformylglycinamide amidotransferase (human PFAS), which catalyzes the fourth reaction in de novo purine synthesis, contains two AIR synthase-related protein C-terminal and one AIR synthase N-terminal domains Phosphoribosylformylglycinamidine synthase F10F2.3 F10F2.3 Member of the class 2 lipase family, has moderate similarity to uncharacterized C. elegans T01C3.4 lipase (Bacillus subtilis) F10F2.4 F10F2.4 Protein containing nine leucine rich repeats, which mediate protein-protein interactions, and a leucine rich repeat C-terminal cysteine rich domain, has low similarity to uncharacterized glycoprotein A repetitions predominant (human GARP) 2 leucine rich domains F10F2.5 F10F2.5 Member of the C-type lectin family, has weak similarity to human versican chondroitin sulfate proteoglycan C-lectin binding domain F10F2.6 F10F2.6 Member of the C-type lectin family, has weak similarity to human versican chondroitin sulfate proteoglycan and human lymphocyte antigen LY75 C-lectin binding domain F10F2.7 F10F2.7 Member of the C-type lectin family, has weak similarity to human lymphocyte antigen 75 (LY75), has weak similarity to versican, aggrecan, and neurocan chondroitin sulfate proteoglycans C-lectin binding domain F10F2.8 F10F2.8 Member of the C-type lectin family, has weak similarity to human versican and aggrecan chondroitin sulfate proteoglycans C-lectin binding domain F10F2.9 F10F2.9 Protein with weak similarity to C. elegans Y113G7B.12 gene product The protein product of this gene is predicted to contain a glutamine/asparagine (Q/N)-rich ('prion') domain, by the algorithm of Michelitsch and Weissman (as of the WS77 release of WormBase, i.e., in wormpep77). F10G2.1 F10G2.1 Protein containing one DUF19 domain of unknown function, which contain twelve conserved cysteines, has high similarity to uncharacterized C. elegans F07B7.13 F10G2.2 F10G2.2 Protein of unknown function, has similarity to an uncharacterized C. elegans protein family including F58E6.4 F10G2.3 F10G2.3 Member of the C-type lectin protein family F10G2.4 F10G2.4 Protein of unknown function F10G2.6 F10G2.6 Protein of unknown function, has high similarity to uncharacterized C. elegans H12C20.5 7TM chemoreceptor, srx family F10G2.7 F10G2.7 Protein of unknown function, has moderate similarity to uncharacterized C. elegans F36D3.8 F10G2.8 F10G2.8 Member of the 7-transmembrane chemoreceptor family of G protein-coupled receptors (GPCR), has high similarity to uncharacterized C. elegans C03G6.20 7TM chemoreceptor, srh family F10G2.9 F10G2.9 Protein containing a nuclear hormone receptor ligand-binding domain and a nuclear hormone receptor C4-type zinc finger domain, which bind DNA and may be involved in regulation of transcription zinc finger protein F10G7.1 F10G7.1 Putative ortholog of S. cerevisiae Ydl060p, a protein of unknown function F10G7.10 F10G7.10 Member of the transthyretin-like family, contains a putative zinc finger in N-recognin domain F10G7.2 F10G7.2 Protein with high similarity to EBNA-2 co-activator (human p100), which is a gene expression coactivator that may bind single-stranded DNA and is required for normal cell growth, member of the staphylococcal nuclease family, contains a tudor domain human 100 kDa activator protein F10G7.3 F10G7.3 Protein with moderate similarity to S. cerevisiae Asf1p, which is a component of replication-coupling chromatin assembly factor (RCAF) and a target of the Rad53p-dependent DNA damage response F10G7.4 coh-2;F10G7.4 Sister chromatid cohesion protein, believed to function in a double strand break DNA repair pathway DNA double-strand break repair; scc-1 encodes a member of the Rad21/Rec8-like family of cohesion proteins that affects embryonic viability, fertility, the rate of embryonic cell divisions and the incidence of male progeny; interacts with ATL-1, F56D12.5, and F11E6.1 based on yeast two-hybrid assays, and is expressed in nondividing embryonic and germline nuclei. F10G7.5 F10G7.5 Protein of unknown function, has low similarity to uncharacterized C. elegans Y59A8B.21 F10G7.6 F10G7.6 Putative ortholog of C. elegans W03B1.5 gene product F10G7.7 F10G7.7 Member of the C. elegans Sre G protein-coupled chemoreceptor family, which are putative chemosensory receptors F10G7.8 rpn-5;F10G7.8 Putative non-ATPase subunit of 19S particle of the 26S proteasome complex F10G7.9 F10G7.9 Protein with moderate similarity to C. elegans C01G5.3 gene product F10G8.2 F10G8.2 Protein with moderate similarity to C. elegans T09B4.7 gene product Eukaryotic protein kinase domain F10G8.3 F10G8.3 Protein with high similarity to RNA export 1 homolog (human RAE1), which is an RNA-binding protein that may function in the nuclear export of mRNA, contains five WD domains (WD-40 repeat), which may mediate protein-protein interactions polyA RNA export protein F10G8.4 F10G8.4 Member of the protein-tyrosine phosphatase family, which are involved in control of cell growth, proliferation, differentiation and transformation, has low similarity to a region of protein tyrosine phosphatase (receptor-type, kappa) (human PTPRK) protein-tyrosine phosphatase F10G8.5 ncs-2;Ce-ncs-2;F10G8.5 Protein that inhibits rhodopsin phosphorylation in a calcium-dependent manner NCS-2 neuronal calcium sensor protein F10G8.6 F10G8.6 Member of the nucleotide binding protein family nucleotide binding protein; This gene encodes a protein predicted by Eisenberg and coworkers, with 52% accuracy, to be mitochondrial. F10G8.7 F10G8.7 Protein with low similarity to excision repair cross complementing 1 (mouse Ercc1), which is an endonuclease which forms a complex with XPF (ERCC4) to function in nucleotide excision and DNA crosslink repair and is essential for viability DNA excision repair protein F10G8.8 F10G8.8 Coiled-coil protein containing two PH (pleckstrin homology) domains (commonly found in signaling proteins) PH (pleckstrin homology) domain (2 domains) F10G8.9 F10G8.9 Protein containing one beta-ketoacyl synthase N-terminal domain, which are involved in dimer formation and one beta-ketoacyl synthase C-terminal domain, has moderate similarity to S. cerevisiae Cem1p, which is a mitochondrial beta-ketoacyl-ACP synthase beta-ketoacyl synthase; This gene encodes a protein predicted by Eisenberg and coworkers, with 68% accuracy, to be mitochondrial. F11A1.2 F11A1.2 Protein of unknown function F11A1.3 daf-12;daf-20;mig-7;F11A1.3 Protein similar to nuclear hormone receptors; required for progression from the L2d pre-dauer larval stage to the normal dauer larval stage; involved in heterochronic life stage transitions daf-12 encodes a member of the steroid hormone receptor superfamily that affects dauer formation downstream of the TGF- and insulin signaling pathways, and affects gonad-dependent adult longevity together with DAF-16, chemosensory signal transduction, and distal tip cell migration and hypodermal and intestinal cell lineages during the L3 larval stage; expressed in the nucleus and in most cells; DAF-12 is homologous to human VITAMIN D RECEPTOR (VDR; OMIM:601769, mutated in vitamin D-resistant rickets. F11A10.1 F11A10.1 Putative ATPase of the AAA family of ATPases TAT-binding homolog like F11A10.2 F11A10.2 Protein with low similarity to S. cerevisiae Prp11p, which is a pre-mRNA splicing factor that is associated with U2, U4, U5, and U6 snRNPs F11A10.3 F11A10.3 Protein containing five CCCH-type zinc finger domains, a zinc knuckle domain, and a C3HC4 type (RING) zinc finger, has a region of high similarity to a region of cleavage and polyadenylation specific factor 4 30 kDa subunit (human CPSF4) Zinc finger, C3HC4 type (RING finger) F11A10.4 F11A10.4 Protein of unknown function F11A10.5 F11A10.5 Protein of unknown function, has high similarity to uncharacterized human ST7 F11A10.6 F11A10.6 Protein with moderate similarity to D. melanogaster CG9536 (CG9536 gene product) F11A10.7 F11A10.7 Protein with weak similarity to C. elegans sap-49 gene product F11A3.1 F11A3.1 Member of the AMP-binding enzyme family, has weak similarity to C. albicans Acs1p, which is an acetyl-coenzyme A synthetase (acetate-coA ligase) 4-coumarate-CoA ligase F11A3.2 F11A3.2 Member of the initiation factor 2 subunit family, has weak similarity to eukaryotic translation initiation factor 2B delta subunit (rat Eif2b), which is a component of the guanine nucleotide-exchange factor for eukaryotic initiation factor eIF-2B guanine nucleotide exchange factor F11A5.1 F11A5.1 Member of the 7-transmembrane chemoreceptor family of G protein-coupled receptors (GPCR), has high similarity to uncharacterized C. elegans F11A5.2 F11A5.10 glc-1;F11A5.10 Avermectin-sensitive glutamate-gated chloride channel GluCl-alpha subunit ligand-gated ion channel; glc-1 encodes the alpha subunit of a glutamate-gated chloride channel and forms a functional channel in Xenopus oocytes; mutations genetically interact with avr-14 and avr-15 mutations such that triple mutants exhibit high level resistance to ivermectin. F11A5.11 F11A5.11 Member of the 7-transmembrane chemoreceptor family of G protein-coupled receptors (GPCR), has moderate similarity to uncharacterized C. elegans SRI-36 F11A5.12 F11A5.12 Member of the short-chain dehydrogenase-reductase family, which are NAD- or NADP-dependent oxidoreductases, has moderate similarity to rat Hsd17b3, which is a type III hydroxysteroid 17-beta dehydrogenase that converts androstenedione to testosterone Estradiol 17-beta-dehydrogenase; This gene encodes a protein predicted by Eisenberg and coworkers, with 68% accuracy, to be mitochondrial. F11A5.13 F11A5.13 Protein of unknown function F11A5.2 F11A5.2 Member of the 7-transmembrane chemoreceptor family of G protein-coupled receptors (GPCR), has high similarity to uncharacterized C. elegans F11A5.1 F11A5.3 F11A5.3 Protein with high similarity to ras-related GTP-binding protein 2 (human RAB2), which is a GTPase that plays a role in vesicle transport from the ER to the Golgi and is associated with Searzy syndrome, member of the Ras superfamily of GTP-binding proteins RAS related protein F11A5.4 F11A5.4 Protein with high similarity to ras-related GTP-binding protein 2 (human RAB2), which is a GTPase that plays a role in vesicle transport from the ER to the Golgi and is associated with Searzy syndrome, member of the Ras superfamily of GTP-binding proteins RAS related protein F11A5.5 F11A5.5 Member of the glycosyl transferase family 11, which hydrolyze the glycosidic bond between two or more carbohydrates, has high similarity to uncharacterized C. elegans K06H6.6 F11A5.6 F11A5.6 Protein with moderate similarity to C. elegans C18A11.6 gene product F11A5.7 F11A5.7 Protein containing one DUF41 domain of unknown function, has high similarity to uncharacterized C. elegans Y73F8A.18 F11A5.8 F11A5.8 Protein containing one DUF33 domain of unknown function, has high similarity to uncharacterized C. elegans B0399.2 F11A5.9 F11A5.9 Member of the sugar (and other) transporter family, has weak similarity to brain-specific Na+-dependent inorganic phosphate cotransporter (rat BNPI), which is a vesicular glutamate transporter that has a presynaptic role in glutamatergic neurotransmission sodium/phosphate transporter F11A6.1 kpc-1;CelfurPC;F11A6.1 Putative furin endoprotease, predicted to cleave preproteins near pairs of basic residues Furin like serine protease; kpc-1 encodes two isoforms of a Kex2/subtilisin-like proprotein convertase that is a member of the subtilase family of calcium-dependent serine endoproteinases that includes mammalian furin (OMIM:136950) and Saccharomyces cerevisiae Kex2p; KPC-1 is required for normal growth and locomotion and is likely responsible for the processing of transforming growth factor (TGF) beta proproteins encoded by daf-7, dbl-1, and unc-129. F11A6.2 F11A6.2 Protein with low similarity to plasma membrane phospholipid scramblase 1 (human PLSCR1), which mediates Ca2+-dependent movement of membrane phospholipids in activated, injured, or apoptotic cells and is a substrate of tyrosine kinase c-Abl F11A6.2 encodes a homolog of human scramblase (PLSCR1; OMIM:604170), which is activated by a rise of intracellular calcium, and which promotes the exposure of phosphatidylserine on the surface of cells undergoing activation, injury, or apoptosis; paralogs of F11A6.2 include C04E12.7, T22H2.5, ZK1053.5. F11C1.1 F11C1.1 Protein of unknown function, has high similarity to uncharacterized C. elegans F42H10.2 F11C1.2 F11C1.2 Protein of unknown function, has similarity to C. elegans F55F8.6 F11C1.3 F11C1.3 Member of the CD36 family of putative scavenger receptors, has low similarity to scavenger receptor BI (mouse Srb1), which mediates the selective uptake of cholesterol from high and low density lipoproteins and activates endothelial nitric oxide membrane glycoprotein F11C1.4 F11C1.4 Protein with strong similarity to C. elegans F26A3.1 gene product F11C1.5 F11C1.5 Protein of unknown function, has moderate similarity to uncharacterized human KIAA0564 nir like gene involved in denitrification F11C1.6 nhr-25;F11C1.6 Member of FTZ-F1 family of nuclear receptors and essential for embryogenesis nuclear hormone receptor; nhr-25 encodes a nuclear hormone receptor orthologous to Drosophila Ftz-F1; NHR-25 is required for embryogenesis, molting, vulval and gonadal development, and hypodermal expression of acn-1; nhr-25 is expressed in gonads and loaded into embryos as a maternal transcript; nhr-25 is zygotically expressed in progeny of the E cell, and then in hypodermis and gut; the role of NHR-25 in molting may be evolutionarily conserved between nematodes and arthopods. F11C3.1 F11C3.1 Protein with strong similarity to C. elegans F59H6.5 gene product F11C3.2 unc-122;F11C3.2 Olfactomedin homolog involved in the sprouting of the C. elegans DVB neuron; mutations lead to a defect in cholinergic synaptic transmission unc-122 encodes a predicted type II transmembrane protein with extracellular collagen-like domains and a highly conserved olfactomedin (OLF) domain that is found in a family of secreted proteins involved in formation and function of nervous systems; UNC-122 is required for proper locomotion and for normal morphology of the DVB motorneuron, and may regulate neuromuscular function by acting in an aminergic/peptidergic pathway parallel to cholinergic neurotransmission; although mosaic analysis indicates that UNC-122 activity is required in muscle cells, the precise expression and localization patterns of UNC-122 are not yet known. F11C3.3 unc-54;mhc-b;myo-b;myo-4;Myosin-B;Band-2-myosin;F11C3.3 Sarcomeric Myosin Heavy Chain, major component of thick filaments in body-wall muscle myosin heavy chain; unc-54 encodes a muscle myosin class II heavy chain (MHC B); UNC-54 is the major myosin heavy chain expressed in C. elegans and is required for locomotion and egg-laying; in vivo and in vitro, UNC-54 interacts with ITR-1, an IP3 receptor, and this interaction may provide a link between calcium signaling and the muscle cytoskeleton; UNC-54 is a thick filament component that is expressed in multiple muscle cell classes including body wall, intestinal, anal depressor, and sphincter muscles as well as sex-specific muscles that develop postembryonically. F11C7.1 F11C7.1 Protein containing a neurotransmitter-gated ion-channel ligand binding domain, has low similarity to a region of C. elegans DEG-3, which is a subunit of the nicotinic acetylcholine receptor that is associated with neuronal degeneration ligand-gated ionic channel F11C7.2 F11C7.2 Protein containing a type 1 thrombospondin domain, has a region of low similarity to a region of semaphorin 5B (semaphorin G, mouse Sema5b), which is involved in embryogenesis and morphogenesis F11C7.3 vap-1;F11C7.3 Member of the SCP-like extracellular protein family, has a region of low similarity to a region of specific granule protein 28kDa (human SGP28), which is a glycoprotein that is widely expressed and localizes to specific granules in neutrophils F11C7.4 crb-1;F11C7.4 Notch family member; has strong similarity to D. melanogaster crb (crumbs) protein which is involved in cell polarity EGF-like repeats; crb-1 encodes a homolog of Drosophila CRUMBS that affects dauer formation and feeding behavior; CRB-1 can bind cyclic AMP-response element (CRE) sites and be phosphorylated by PKA in vitro, and is expressed immediately apical to the zonula adherens in embryos and then ubiquitously later during development and in adults; CRB-1 is homologous to human CRB1 (OMIM:604210, mutated in retinitis pigmentosa 12 or Leber congenital amaurosis). F11C7.5 F11C7.5 Protein of unknown function, has weak similarity to C. elegans T05D4.4 F11D11.1 F11D11.1 Protein containing a C-type lectin domain, which mediate calcium-dependent carbohydrate recognition, has moderate similarity to uncharacterized C. elegans Y17D7B.6 F11D11.10 F11D11.10 Protein with moderate similarity to C. elegans Y22D7AL.2 gene product F11D11.2 F11D11.2 Protein with strong similarity to C. elegans T20H12.2, which is a transposase, member of the transposase family, which are required for excising and inserting mobile genetic elements F11D11.3 F11D11.3 Protein of unknown function, has moderate similarity to uncharacterized C. elegans ZK6.10 F11D11.4 F11D11.4 Putative ortholog of C. elegans F11D11.3 gene product F11D11.5 F11D11.5 Protein containing a C-type lectin domain, which mediate calcium-dependent carbohydrate recognition, has high similarity to uncharacterized C. elegans F11D11.8 F11D11.6 F11D11.6 Protein containing a C-type lectin domain, which mediate calcium-dependent carbohydrate recognition, has low similarity to uncharacterized C. elegans Y17D7B.6 F11D11.7 F11D11.7 Protein of unknown function, has high similarity to uncharacterized C. elegans F11D11.5 F11D11.8 F11D11.8 Protein of unknown function, has high similarity to uncharacterized C. elegans F11D11.5 F11D11.9 F11D11.9 Member of the transposase family, which are required for excising and inserting mobile genetic elements, has very strong similarity to uncharacterized C. elegans Y95B8A.3 HYPOTHETICAL 29.3 KD PROTEIN B0280.6 IN CHROMOSOME III F11D5.1 F11D5.1 Putative ortholog of C. elegans ZK816.2 gene product F11D5.3 F11D5.3 Protein containing two F5 or 8 type C (discoidin) domains and two protein kinase domains, has low similarity to discoidin domain receptor 2 (human DDR2), which is a receptor protein tyrosine kinase that is activated by collagen tyrosine kinase; F11D5.3 encodes a putative tyrosine kinase homologous to human RS1 (OMIM:312700, mutated in juvenile X-linked retinoschisis). F11D5.4 F11D5.4 Protein of unknown function, has low similarity to uncharacterized C. elegans F11D5.5 F11D5.5 F11D5.5 Protein of unknown function, has high similarity to uncharacterized C. elegans K09C4.1 glucose transporter (weak) F11D5.6 F11D5.6 Protein of unknown function F11E6.1 F11E6.1 Putative ortholog of C. elegans F11E6.1 gene product glucosylceramidase (O-glycosyl hydrolase); F11E6.1 is homologous to to the human gene GLUCOCEREBROSIDASE (GBA; OMIM:606463), which when mutated leads to Gaucher disease. F11E6.2 F11E6.2 Protein of unknown function F11E6.3 F11E6.3 Protein of unknown function, has weak similarity to a region of heavy polypeptide of neurofilament (mouse Nfh), which is a cytoskeletal structural protein that may regulate axonal caliber, synaptic transmission, and type IV intermediate filament assembly F11E6.4 F11E6.4 Protein of unknown function F11E6.5 F11E6.5 Member of the GNS1 or SUR4 family of integral membrane proteins, has moderate similarity to polyunsaturated fatty acid (PUFA) elongase (C. elegans CEEl01), which contains the condensation activity required for fatty acid elongation GNS1/SUR4 family; The elo-2 gene encodes a palmitic acid elongase, homologous to polyunsaturated fatty acid (PUFA) elongases such as ELO-1, that is required for normally rapid growth, normally large body size, fertility, and for the quantitative regulation of the ultradian defecation rhythm; the joint action of ELO-2 with ELO-1 is strongly required for 20-carbon PUFA production and for general viability; elo-2 is most strongly expressed in intestinal cells, as well as other tissues such as the ventral nerve cord, pharyngeal muscles, uterus, and tail. F11E6.6 F11E6.6 Protein of unknown function F11E6.7 F11E6.7 Protein of unknown function, has high similarity to uncharacterized C. elegans F19H6.3 F11E6.8 F11E6.8 Protein containing a protein kinase domain, has low similarity to v-src avian sarcoma viral oncogene homolog (Schmidt-Ruppin A-2, human SRC), which is a tyrosine kinase involved in cell proliferation, cell adhesion, and cytoskeletal organization Eukaryotic protein kinase domain F11F1.1 F11F1.1 Member of the Hsp70 family, which are stress-induced protein chaperones, has moderate similarity to heat shock 70kD protein 8 (rat Hspa8), which is involved in protein folding, translocation, and assembly into complexes Heat shock hsp70 proteins F11F1.2 F11F1.2 Protein containing one DUF148 domain of unknown function, has strong similarity to uncharacterized C. elegans F11F1.5 F11F1.4 F11F1.4 Protein containing one DUF148 domain of unknown function, has strong similarity to uncharacterized C. elegans F11F1.2 F11F1.5 F11F1.5 Protein containing one DUF148 domain of unknown function, has strong similarity to uncharacterized C. elegans F11F1.2 F11F1.6 F11F1.6 Protein of unknown function F11F1.7 F11F1.7 Member of the transthyretin-like family Transthyretin-like family F11G11.1 F11G11.1 Protein containing glutathione S-transferase N-terminal and C-terminal domains, has low similarity to prostaglandin D2 synthase (human PGDS), which is a prostaglandin D synthase and glutathione S-transferase that regulates non-rapid eye movement sleep glutathione S-transferase; gst-8 encodes a predicted glutathione S-transferase. F11G11.10 col-17;F11G11.10 Protein of unknown function, has a region of low similarity to glutamine repeat protein 1 (mouse Glrp1), which is a putative transcription factor that may be involved in the immune response collagen; col-17 encodes a collagen which is expressed in all developmental stages except eggs, like col-15, col-16, and col-20; collagen genes with this expression pattern may be used for synthesis of cuticles after the L1 stage (e.g., the L4 cuticle). F11G11.11 col-20;F11G11.11 Putative collagen, has strong similarity to C. elegans COL-17 collagen collagen; col-20 encodes a collagen; its expression pattern and mutant phenotypes are unknown. F11G11.12 F11G11.12 Protein containing two collagen triple helix repeats, which are found in some extracellular proteins, and a nematode cuticle collagen N-terminal domain, has a region of moderate similarity to a region of type XI collagen alpha 2 subunit (human COL11A2) collagen F11G11.13 F11G11.13 Protein containing an ATP:guanido phosphotransferase C-terminal catalytic domain F11G11.2 F11G11.2 Protein containing glutathione S-transferase N-terminal and C-terminal domains, has low similarity to prostaglandin D2 synthase (human PGDS), which is a prostaglandin D synthase and glutathione S-transferase that regulates non-rapid eye movement sleep glutathione S-transferase; gst-7 encodes a predicted glutathione S-transferase. F11G11.3 F11G11.3 Protein containing glutathione S-transferase N-terminal and C-terminal domains, has low similarity to prostaglandin D2 synthase (human PGDS), which is a prostaglandin D synthase and glutathione S-transferase that regulates non-rapid eye movement sleep glutathione S-transferase; gst-6 encodes a predicted glutathione S-transferase. F11G11.4 F11G11.4 Protein of unknown function, has strong similarity to uncharacterized C. elegans C24D10.2 F11G11.5 F11G11.5 Protein of unknown function F11G11.6 F11G11.6 Protein of unknown function F11G11.7 F11G11.7 Protein containing one DnaJ domain, which are part of chaperone system that mediates interaction with heat shock proteins, has a region of high similarity to a region of dnaJ homolog subfamily B member 4 (human DNAJB4), which is a heat shock protein This gene encodes a protein containing a DnaJ ('J') domain. F11G11.8 F11G11.8 Protein of unknown function F11G11.9 F11G11.9 Protein containing a rhodanese-like domain, has weak similarity to thiosulfate sulfotransferase (rhodanese, human TST), which is a thiosulfate sulfotransferase enzyme that functions in the detoxification of cyanide F11H8.1 uba-3;F11H8.1 Protein with high similarity to ubiquitin-activating enzyme E1C (human UBE1C), which is a subunit of an E1-like complex, member of the UBA-THIF-type NAD-FAD binding fold family, contains a repeat in ubiquitin-activating (UBA) protein domain ubiquitin-activating enzyme; rfl-1 (also known as cyk-5) encodes an ortholog of UBA3, a Nedd8 activating enzyme for ubiquitin-like proteins, which is required for proper cytokinesis and spindle orientation; NED-8 is presumably activated by an ULA-1/RFL-1 heterodimer. F11H8.2 F11H8.2 Protein containing a neurotransmitter-gated ion-channel transmembrane and two ligand binding domains, has moderate similarity to C. elegans UNC-49 gamma-aminobutyric acid receptor F11H8.3 col-8;F11H8.3 Collagen of the collagen triple helix repeat (20 copies) family col-8 encodes a collagen, individually dispensable for viability and gross morphology, which is specifically expressed in dauers and adults but not in eggs or L4 larvae, like col-7, col-18, and col-19; the amino- and carboxyl-terminal cysteine-rich regions of COL-8 are most closely related to those of COL-19, COL-35, and COL-39. F11H8.4 cyk-1;F11H8.4 Formin homology (FH) family member required for completion of cytokinesis required for a late step in embryonic cytokinesis; The cyk-1 gene encodes a homolog of Drosophila diaphanous and human DIAPH1. F12A10.1 F12A10.1 Protein of unknown function F12A10.2 F12A10.2 Putative ortholog of C. elegans F59E12.6 gene product F12A10.3 F12A10.3 Protein containing three pyridoxal-dependent group II decarboxylase conserved domains, which bind pyridoxal-phosphate groups, has moderate similarity to dopa decarboxylase (aromatic L-amino acid decarboxylase, rat Ddc) aromatic-L-amino-acid decarboxylase F12A10.4 F12A10.4 Member of the M13 peptidase family of zinc metalloproteases, has weak similarity to mel transforming oncogene-like protein1 1 (mouse Mell1), which is a type II membrane bound metalloprotease that has a secreted alternative form Neprilysin; F12A10.4 encodes a neprilysin; neprilysins are thermolysin-like zinc metallopeptidases, found on the outer surface of animal cells, that negatively regulate small signalling peptides (e.g., enkephalin, tachykinin, insulin, and natriuretic peptides) by cleaving them; F12A10.4 has no clear orthologs in other organisms. F12A10.5 F12A10.5 Protein with high similarity to calmodulin 1 (human CALM1), which regulates the calcium-dependent activity of proteins and enzymes including ion channels, kinases, phosphatases, and phosphodiesterases, contains four EF hand domains Calmodulin F12A10.6 F12A10.6 Protein with moderate similarity to C. elegans ZK177.2 gene product F12A10.7 F12A10.7 Protein of unknown function F12A10.8 F12A10.8 Protein of unknown function F12B6.1 F12B6.1 Member of the ABC transporter family, has low similarity to ATP binding cassette subfamily A member 1 (human ABCA1), which mediates the transport of cholesterol, phospholipids and anions and plays a role in endocytosis abc transporter F12B6.2 F12B6.2 Member of the sugar (and other) transporter family, has weak similarity to C. elegans EAT-4, which is a putative Na+/Pi-cotransporter involved in muscle contraction, mechanosensory perception, synaptic transmission, and chemotaxis sodium dependent-phosphate transporter F12B6.3 F12B6.3 Protein containing two neurotransmitter-gated ion-channel ligand binding domains, has low similarity to the inhibitory glycine receptor alpha 3 subunit (rat Glra3), which may play a role in the modulation of neuronal differentiation and excitability ligand-gated ionic channel F12D9.1 F12D9.1 Protein of unknown function F12D9.2 F12D9.2 Protein of unknown function F12E12.1 F12E12.1 Putative ortholog of C. elegans F12E12.I gene product F12E12.3 F12E12.3 Putative ortholog of C. elegans F12E12.G gene product F12E12.4 F12E12.4 Putative ortholog of C. elegans F12E12.F gene product F12E12.7 F12E12.7 Putative ortholog of C. elegans F12E12.A gene product F12E12.D F12E12.6;F12E12.D Protein of unknown function F12E12.E F12E12.5;F12E12.E Protein with strong similarity to C. elegans C46E10.9 gene product F12E12.H F12E12.2;F12E12.H Protein of unknown function F12F3.1 exp-2;nShab3;F12F3.1 Inward rectifying pharyngeal K-type (voltage activated) potassium channel potassium channel protein F12F3.2 F12F3.2 Protein containing 4 fibronectin type III domains, 32 immunoglobulin (Ig) domains, and 2 protein kinase domains, has weak similarity to a region of titin (human TTN), which is a sarcomeric protein that maintains resting tension in muscle F12F3.3 F12F3.3 Putative member of the Immunoglobulin superfamily of muscle proteins F12F6.1 F12F6.1 Protein of unknown function F12F6.2 F12F6.2 Protein of unknown function F12F6.3 rib-1;F12F6.3 Protein of unknown function, has high similarity to a region of exostoses 1 (human EXT1), which forms a glycosyltransferase complex with EXT2 that catalyzes the polymerization of heparan sulfate glycosaminoglycans MULTIPLE EXOSTOSES HOMOLOG 1; The rib-1 gene encodes an ortholog of human EXT1, which when mutated leads to hereditary multiple exostoses, type I (OMIM:133700). F12F6.5 F12F6.5 Protein of unknown function, has similarity to human chimaerin chimaerin like F12F6.6 F12F6.6 Protein with moderate similarity to SEC24 (S. cerevisiae) related gene family member C (human SEC24C), which is a putative COPII vesicle coat protein that may function in cargo recruitment during ER-Golgi transport Yeast hypothetical YIK9 protein like; sec-24.1 encodes one of two C. elegans Sec24 homologs; in Saccharomyces cerevisiae, Sec24 is a member of the Sec24-Sec23 subunit of the COPII coat complex, assembly of which is essential for the first step of secretory protein transport from the endoplasmic reticulum (ER) to the Golgi; by homology with Sec24, SEC-24.1 is predicted to facilitate vesicle cargo selection, and likely contains multiple, independent sites for binding to secreted proteins; loss of sec-24.1 activity via RNAi indicates that SEC-24.1 is required for cuticle secretion and oogenesis. F12F6.7 F12F6.7 Protein with strong similarity to the small subunit of DNA polymerase delta Yeast HUS2 protein like F12F6.8 F12F6.8 Protein of unknown function, has weak similarity to zygote-defective 11 (C. elegans ZYG-11), which is required for zygote formation C.elegans ZYG-11 protein like F12F6.9 F12F6.9 Protein containing two collagen triple helix repeats and one nematode cuticle collagen N-terminal domain, has a region of moderate similarity to a region of the alpha 2 subunit of type XI collagen (human COL11A2), which is important in hearing collagen F13A2.1 F13A2.1 Protein of unknown function F13A2.2 F13A2.2 Protein of unknown function F13A2.3 F13A2.3 Protein of unknown function F13A2.4 F13A2.4 Protein of unknown function F13A2.5 F13A2.5 Protein of unknown function F13A2.6 F13A2.6 Protein with strong similarity to C. elegans Y73F8A.Y gene product F13A2.8 F13A2.8 Protein containing a nuclear hormone receptor ligand-binding domain and nuclear hormone receptor C4-type zinc finger domain, has low similarity to a region of retinoic acid receptor alpha (mouse Rara), which is a ligand activated transcriptional regulator zinc finger protein F13A7.1 F13A7.1 Protein containing a major sperm protein (MSP) domain, which are involved in sperm motility F13A7.10 F13A7.10 Protein containing glutathione S-transferase N-terminal and C-terminal domains, has moderate similarity to glutathione-S-transferase like (human GSTTLp28), which is a thiol transferase and a dehydroascorbate reductase that modulates ryanodine receptors glutathione S-transferase F13A7.11 F13A7.11 Protein of unknown function, has high similarity to uncharacterized C. elegans C06B3.6 F13A7.2 F13A7.2 Protein of unknown function, has high similarity to uncharacterized C. elegans H04J21.2 7TM receptor F13A7.3 F13A7.3 Protein with moderate similarity to C. elegans F13A7.4 gene product G-protein coupled receptor, srv family F13A7.4 F13A7.4 Protein with moderate similarity to C. elegans F13A7.3 gene product F13A7.6 F13A7.6 Member of the 7-transmembrane chemoreceptor family of G protein-coupled receptors (GPCR), has moderate similarity to uncharacterized C. elegans F13A7.8 F13A7.7 F13A7.7 Protein with strong similarity to C. elegans F22H10.4 gene product F13A7.8 F13A7.8 Member of the 7-transmembrane chemoreceptor family of G protein-coupled receptors (GPCR), has moderate similarity to uncharacterized C. elegans D2062.3 7TM chemoreceptor, sri family F13A7.9 F13A7.9 Member of the Skp1 family, which are required for targeted protein degradation during the cell cycle, has low similarity to S. cerevisiae Skp1p, which is a component of SCF complexes involved in protein degradation The skr-11 gene encodes a homolog of Skp1 in S. cerevisiae that has no known function in vivo, since skr-11(RNAi) animals are at least superficially normal. F13B10.1 CeSARM;F13B10.1 Protein containing two SAM (sterile alpha motif) domains, which may mediate protein-protein interactions, and two TIR (Toll-IL-1R) domains, which may mediate protein-protein interactions SAM domain (Sterile alpha motif); tir-1 encodes a protein that may be involved in apoptosis: from N- to C-terminus, it has three domains; the first two are sterile alpha motif (SAM) domains; the last is a Toll-interleukin 1 (IL1) receptor (TIR) domain. F13B10.2 rpl-3;F13B10.2 Member of the ribosomal L3 protein family 60S ribosomal protein L3; rpl-3 encodes a large ribosomal subunit L3 protein required in mass RNAi assays for embryonic and larval viability, fertility, and general health; the rpl-3 transcription unit has a nonsense transcript that is up-regulated in vivo by smg[-] mutations, indicating that rpl-3 is a natural substrate for SMG-mediated nonsense suppresssion; several other natural mRNA substrates of SMG suppression (e.g., rpl-7, rpl-10, rpl-12) have protein products that are involved in translation. F13B12.1 F13B12.1 Protein of unknown function, has low similarity to uncharacterized human FLJ10006 F13B12.2 F13B12.2 Member of the sugar (and other) transporter family, has low similarity to facilitative glucose transporter 2 (human SLC2A2), which is a low-affinity, high-capacity glucose transporter that is associated with Fanconi-Bickel syndrome glucose tranporter like F13B12.3 F13B12.3 Protein with moderate similarity to C. elegans W03B1.2 gene product F13B12.4 F13B12.4 Member of the pyridoxal phosphate dependent enzyme beta family, has high similarity to uncharacterized C. elegans F01D4.8 cysteine synthase like F13B12.5 ins-1;ILP1;F13B12.5 Member of the insulin, insulin-like growth factor (IGF) or relaxin family, which act as secreted regulatory peptide hormones ins-1 encodes an insulin-like peptide orthologous to human insulin (INS; OMIM:176730, mutated in hyperproinsulinemia and diabetes mellitus type II); INS-1 is one of 38 insulin-like peptides in C. elegans and when overexpressed can antagonize insulin-like signaling mediated by DAF-2/IR leading to arrest at the dauer larval stage; loss of INS-1, however, does not result in a dauer phenotype suggesting that INS-1 functions redundantly with other insulin-like peptides to regulate reproductive growth and lifespan; INS-1 is expressed in the amphid sensory neurons ASI and ASJ that regulate dauer arrest, the nerve ring, the intestine, vulval muscles, and other neurons. F13B12.6 F13B12.6 Protein of unknown function F13B6.1 F13B6.1 Protein with strong similarity to C. elegans F13B6.2 gene product F13B6.2 F13B6.2 Protein with strong similarity to C. elegans F13B6.1 gene product F13B6.3 F13B6.3 Protein with strong similarity to C. elegans nhr-1 gene product F13B9.1 F13B9.1 Putative ortholog of C. elegans ZK512.5 gene product F13B9.1 encodes two proteins by alternative splicing which contain both an immunoglobulin/MHC-like domain and a glutamine/asparagine-rich domain. F13B9.2 F13B9.2 Protein of unknown function, has weak similarity to C. elegans Y34B4A_3.C F13B9.5 ksr-1;sur-3;F13B9.4;F13B9.5 Raf-like serine/threonine protein kinase involved in larval and vulval development, has similarity to human and D. melanogaster KSR (kinase suppressor of ras) protein kinases F13B9.8 F13B9.8 Protein of unknown function, has moderate similarity to uncharacterized human LOC51024 F13C5.1 F13C5.1 Protein of unknown function F13C5.2 F13C5.2 Protein containing a bromodomain, which interact specifically with acetylated lysine, has a region of moderate similarity to a region of bromodomain-containing 2 (human BRD2), which is a protein kinase that may be associated with leukemias bromodomain-containing protein F13C5.3 F13C5.3 Protein of unknown function F13C5.4 F13C5.4 Protein of unknown function F13C5.5 F13C5.5 Protein of unknown function F13C5.6 F13C5.6 Putative ortholog of C. elegans F13C5.7 gene product gei-10 encodes a novel protein conserved with C. briggsae BP:CBP01944 that interacts with GEX-3 in yeast two-hybrid assays. F13D11.1 F13D11.1 Member of the histidine acid phosphatase family, which hydrolyze phosphate esters at low pH, has low similarity to rat Acp2, which is a tartrate-inhibitable lysosomal acid phosphatase histidine acid phosphatase family (weak) F13D11.2 hbl-1;F13D11.2 Protein involved in differentiation of several tissues including the hypodermis; has strong similarity to D. melanogaster hb gene product C2H2-type zinc finger; hbl-1 encodes a protein that contains nine putative zinc finger domains of the C2H2 type and affects embryonic viability, locomotion, egg laying, body morphology, and hypodermal differentiation; expressed in hypodermal precursor cells, neuronal precursor cells, and pharyngeal cells during embryogenesis and is primarily expressed in neurons during larval development. F13D11.3 F13D11.3 Protein containing a dual specificity phosphatase catalytic domain, has moderate similarity to human DUSP13, which is a dual specificity phosphatase that may play a role in regulation of meiosis and differentiation of testicular germ cells protein tyrosine-phosphatase family F13D11.4 F13D11.4 Protein with low similarity to S. cerevisiae Gre2p, which is involved in diamide tolerance and is induced by osmotic stress dihydroflavonol-4-reductase (maize, petunia, tomato) F13D12.2 ldh-1;LDH;ldh;F13D12.2 Lactate dehydrogenase L-lactate dehydrogenase; ldh-1 is orthologous to the human gene LACTATE DEHYDROGENASE B (LDHB; OMIM:150100), which when mutated leads to lactate dehydrogenase-B deficiency. F13D12.3 F13D12.3 Protein of unknown function F13D12.4 F13D12.4 Protein with high similarity to methylmalonate-semialdehyde dehydrogenase (rat Mmsdh), which is involved in valine and pyrimide catabolism, member of the aldehyde dehydrogenase family, which use NADP as a cofactor methylmalonate-semialdehyde dehydrogenase; alh-8 is orthologous to the human gene METHYLMALONATE-SEMIALDEHYDE DEHYDROGENASE (ALDH6A1; OMIM:603178), which when mutated leads to MMSDH deficiency. F13D12.5 F13D12.5 Protein of unknown function, has moderate similarity to uncharacterized C. elegans T21B10.4 F13D12.6 F13D12.6 Member of the serine carboxypeptidase family, has moderate similarity to cathepsin A (protective protein for beta-galactosidase, human PPGB), which has carboxypeptidase activity and binds human GLB1 and human NEU1 and is associated with galactosialidosis serine carboxypeptidase; F13D12.6 is orthologous to the human gene SIMILAR TO PROTECTIVE PROTEIN FOR BETA-GALACTOSIDASE (GALACTOSIALIDOSIS) (PPGB; OMIM:256540), which when mutated leads to disease. F13D12.7 gpb-1;F13D12.7 Trimeric G protein beta-subunit that appears to act in the regulation of egg-laying and motility, member of the WD repeat family guanine nucleotide-binding protein beta subunit; gpb-1 encodes a heterotrimeric G protein beta subunit that is required during embryonic development for the proper orientation of the mitotic spindle during early cell divisions and thus affects the orientation of early cell division axes, and is also required for larval viability, negatively regulates locomotion and egg-laying, and may affect germline development and osmotic balance; expressed in early embryos with highest expression at cell membranes and colocalizes with asters just before and during early cell divisions (this localization is dependent upon G alpha subunits); adults display high levels of expression in neurons with lower expression in the somatic gonad, vulva, and hypodermal seam cells and expression is also detected in the intestine, pharynx, body wall muscles and in the germline. F13D12.8 F13D12.8 Protein of unknown function F13D2.1 F13D2.1 Protein containing an alpha-2-macroglobulin C-terminal domain, which are found in protease inhibitors alpha-1-macroglobulin-like domain F13D2.2 F13D2.2 Member of the rhodopsin family of G protein-coupled receptors (GPCR), has a region of low similarity to a region of oxytocin receptor (rat Oxtr), which is induced in the uterus prior to labor G-protein coupled receptor F13D2.3 F13D2.3 Member of the rhodopsin family of G protein-coupled receptors (GPCR), has low similarity to uncharacterized C. elegans Y105C5A.23 G-protein coupled receptor F13D2.4 F13D2.4 Protein of unknown function F13E6.1 F13E6.1 Protein of unknown function with moderate similarity to H. sapiens TPD52L2 and H. sapiens TPD52 gene products, which are D52 tumor proteins D52 protein F13E6.2 F13E6.2 Protein of unknown function, has a region of low similarity to cytosolic adenylate kinase 1 (mouse Ak1), which acts in adenine nucleotide homeostasis, energetic homeostasis, and neuronal function adenylate kinase like F13E6.3 F13E6.3 Protein of unknown function, has weak similarity to C. elegans F21G4.4 F13E6.4 F13E6.4 Protein containing a WW domain, which bind proline-rich peptide epitopes RSP5 like protein F13E6.5 F13E6.5 Member of the phosphatidic acid phosphatase-related (PAP2) phosphoesterase family, has low similarity to phosphatidic acid phosphatase type 2a (rat Ppap2a), which catalyzes the dephosphorylation of various lipid phosphates F13E6.6 F13E6.6 Protein containing a phorbol esters or diacylglycerol binding domain (C1 domain), which bind two zinc ions, and a RhoGEF (GTPase exchange factor) domain, has low similarity to a region of rho (ARHA) guanine nucleotide exchange factor 12 (human ARHGEF12) Tiam-1 like protein; tag-118/F13E6.6 is orthologous to the human gene RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR 12 (ARHGEF12; OMIM:604763), which, when fused to the MLL gene (OMIM:159555), leads to primary acute myeloid leukemia. F13E9.1 F13E9.1 Protein containing leucine rich repeats, which mediate protein-protein interactions, has high similarity to a region of nischarin (mouse Nisch), which associates with integrin alpha5-beta1 and inhibits integrin-mediated cell migration SD22 like protein F13E9.10 F13E9.10 Protein of unknown function, has weak similarity to C. elegans ZK596.1 F13E9.11 F13E9.11 Protein of unknown function F13E9.2 F13E9.2 Protein of unknown function, has weak similarity to C. elegans F13E9.3 F13E9.3 F13E9.3 Protein of unknown function, has similarity to Synechocystis 6803 BtpA (biogenesis of thylakoid protein A) F13E9.4 F13E9.4 Protein containing one DUF148 domain of unknown function F13E9.5 F13E9.5 Protein of unknown function F13E9.6 F13E9.6 Protein of unknown function F13E9.7 F13E9.7 Protein of unknown function, has moderate similarity to C. elegans C17B7.6 reverse transcriptase F13E9.8 F13E9.8 Protein containing two DUF148 domains of unknown function F13E9.9 F13E9.9 Protein of unknown function F13G11.1 F13G11.1 Protein containing two DM (dsx and mab-3) DNA binding domains F13G11.2 F13G11.2 Protein of unknown function F13G3.1 F13G3.1 Protein containing three C2H2 type zinc finger domains, which bind nucleic acids Zinc finger, C2H2 type F13G3.10 F13G3.10 Protein of unknown function F13G3.11 F13G3.11 Protein of unknown function F13G3.2 F13G3.2 Protein of unknown function, has high similarity to uncharacterized C. elegans K02A2.2, which is predicted to be a G protein-coupled receptor F13G3.3 F13G3.3 Protein containing a DUF23 domain of unknown function, has low similarity to uncharacterized C. elegans F49C12.5 F13G3.4 F13G3.4 Protein with moderate similarity to T-complex testis expressed 1 (rat Tctex1), which is a cytoplasmic dynein light chain that may play a role in vesicle targeting, spermatogenesis, and protein recruitment during cytokinesis F13G3.5 F13G3.5 Member of the inositol monophosphatase family, which participate in the inositol phosphate second messenger signaling pathway, has moderate similarity to a region of rat Impa1, which is an inositol(myo)-1(or 4)-monophosphatase myo-inositol-1-monophosphatase; This gene encodes a protein predicted by Eisenberg and coworkers, with 52% accuracy, to be mitochondrial. F13G3.6 F13G3.6 Member of the glycosyl transferase family 2 B.subtilis teichoic acids biosynthesis protein GGAB like; This gene encodes a protein predicted by Eisenberg and coworkers, with 68% accuracy, to be mitochondrial. F13G3.7 F13G3.7 Member of the mitochondrial carrier protein family of membrane transporters, has moderate similarity to uncharacterized C. elegans Y43C5B.3 Yeast mitochondrial carrier protein like F13G3.8 eat-5;F13G3.8 Member of the integral membrane innexin family, which are involved in the formation of gap junctions, has moderate similarity to C. elegans UNC-7, which is required in motor neurons for coordinated locomotion UNC-7 protein like; eat-5 encodes an innexin, expressed in pharyngeal muscle cell groups pm4 and pm5, that is required for synchronized pharyngeal muscle contractions, and for normal electrical connections between pharyngeal muscle cells; EAT-5 forms electrically permeable intercellular channels (gap junctions), with a predicted membrane topology analogous to that of connexins, which affects electrical coupling between different parts of the pharynx and thus affects feeding. F13G3.9 mif-3;F13G3.9 Protein with moderate similarity to members of the macrophage migration inhibitory factor (MIF) family, has moderate similarity to C. elegans C52E4.2 macrophage migratory inhibitory factor MIF like F13H10.1 F13H10.1 Protein of unknown function F13H10.2 F13H10.2 NADH pyrophosphatase NADH pyrophosphatase; The ndx-9 gene encodes a member of the NADH pyrophosphatase subfamily of the NUDIX hydrolases. F13H10.3 F13H10.3 Protein with weak similarity to S. cerevisiae YJR001W Yeast YEH4 like protein F13H10.4 F13H10.4 Putative glucosidase I (mannosyl-oligosaccharide glucosidase) with a predicted role in the processing of N-linked oligosaccharides F13H10.4 is orthologous to the human gene A-GLUCOSIDASE I (GCS1; OMIM:601336), which when mutated leads to disease. F13H10.5 F13H10.5 Protein containing a type I phosphodiesterase or nucleotide pyrophosphatase domain, has weak similarity to a region of rat Enpp1, which is an ectonucleotide pyrophosphatase-phosphodiesterase and a cell surface tumor and neural differentiation antigen F13H6.1 F13H6.1 Protein containing four C2H2 type zinc finger domains, which bind nucleic acids, has weak similarity to a region of B-cell CLL-lymphoma 11A (mouse Bcl11a), which is involved in the repression of transcription zinc-finger protein F13H6.2 F13H6.2 Protein of unknown function F13H6.3 F13H6.3 Member of the carboxylesterase protein family carboxylesterase F13H6.4 F13H6.4 Member of the carboxylesterase protein family carboxylesterase F13H6.5 F13H6.5 Member of the rhodopsin family of G protein-coupled receptors (GPCR) F13H8.1 F13H8.1 Protein of unknown function F13H8.10 F13H8.10 Protein of unknown function bpl-1 encodes an ortholog of biotin ligase/holocarboxylase synthetase (called biotin ligase in bacteria, and holocarboxylase synthetase in mammalian or animal systems); it is orthologous to human HOLOCARBOXYLASE SYNTHETASE (HLCS; OMIM:253270), which when mutated leads to HLCS deficiency. F13H8.11 F13H8.11 Protein with strong similarity to C. elegans W02B12.1 gene product F13H8.2 F13H8.2 Member of the WD repeat protein family beta transducin Trp-Asp domains; This gene encodes a protein predicted by Eisenberg and coworkers, with 68% accuracy, to be mitochondrial. F13H8.3 F13H8.3 Member of the inosine-uridine preferring nucleoside hydrolase family, contains a major sperm protein (MSP) domain, which are involved in sperm motility, has moderate similarity to uncharacterized C. elegans Y43F8C.13 F13H8.4 F13H8.4 Protein of unknown function F13H8.5 F13H8.5 Protein containing a DB module domain Phospholipase ADRAB-B (Rabbit); F13H8.5 encodes a protein with a domain of unknown function (DB; IPR002602) that is found in several worm proteins, and a glutamine/asparagine-rich domain. F13H8.6 F13H8.6 Protein of unknown function F13H8.7 F13H8.7 Putative beta-ureidopropionase (beta-alanine synthase), member of the beta-ureidopropionase branch of the nitrilase superfamily, which also includes Human LOC51733 and Rat Rn11110 that are involved in pyrimidine base catabolism and beta-alanine production beta-ureidopropionase (rat) F13H8.8 F13H8.8 Protein of unknown function, has low similarity to uncharacterized C. elegans M117.4 F13H8.9 F13H8.9 Member of the aminotransferases class-V family of pyridoxal-phosphate-dependent enzymes, has moderate similarity to selenocysteine lyase (mouse Scly), which catalyzes the degradation of L-selenocysteine to L-alanine and elemental selenium Nitrogen fixation (NIFS) F14A5.1 F14A5.1 Protein containing a nuclear hormone receptor C4-type zinc finger domain, which bind DNA and may be involved in regulation of transcription, has a region of low similarity to a region of peroxisome proliferator activated receptor delta (rat Ppard) Zinc finger, C4 type (two domains) F14B4.1 F14B4.1 Protein containing two epidermal growth factor-like domains, two low-density lipoprotein (LDL) receptor class A domains and four class B LDL receptor repeats, has low similarity to a region of C. elegans LRP-1, which is an LDL receptor-related protein LDL receptor-related protein F14B4.2 F14B4.2 Protein with high similarity to glucokinase (human GCK), which converts glucose to glucose-6-phosphate in the first step of glucose metabolism, member of the hexokinase family, which convert aldo- and keto-hexose sugars to hexose-6-phosphate hexokinase F14B4.3 F14B4.3 Member of the RNA polymerases beta subunit family, which are shared among all three types of eukaryotic RNA polymerases, has moderate similarity to the RNA polymerase I 127 kDa subunit (rat Rpo1-2), which is the second largest subunit of RNA polymerase I DNA-directed RNA polymerase I F14B6.1 F14B6.1 Protein with moderate similarity to C. elegans F14B6.3 gene product F14B6.2 F14B6.2 Protein with strong similarity to C. elegans F14B6.7 gene product F14B6.3 F14B6.3 Protein with moderate similarity to C. elegans F14B6.1 gene product F14B6.4 F14B6.4 Member of the galactosyltransferase family, has a region of low similarity to a region of UDP-galactose:beta-N-acetylglucosamine beta-1,3-galactosyltransferase (human B3GALT1), which is downregulated in colon adenocarcinomas F14B6.5 F14B6.5 Protein containing a DUF33 domain of unknown function, has high similarity to uncharacterized C. elegans F41D3.5 F14B6.6 F14B6.6 Member of the galactosyltransferase family, which transfer galactose to GlcNAc termini of growing oligosaccharide chains, has high similarity to uncharacterized C. elegans T09F5.1 F14B8.1 F14B8.1 Member of the sodium or hydrogen exchanger family, which maintain the pH of actively metabolizing cells, has low similarity to sodium-hydrogen exchanger 1 (human SLC9A1), which is an antiporter that plays a role in pH regulation and cell volume regulation NA(+)/H(+) antiporter; nhx-4 encodes two isoforms of a sodium/proton exchanger expressed in the plasma membrane of nearly all cells and cell types; in polarized epithelial cells, NHX-4::GFP appears specifically located in the basolateral membrane, like human SLC9A1 ('NHE1'; OMIM:107310); nhx-4 has no reported mutant or RNAi phenotype, but, given its ubiquitous expression, may represent a housekeeping exchanger generally required for cellular viability; transgenic NHX-4A, when expressed in cell culture, mediates Na[+]-dependent pH recovery after intracellular acidification, independently of extracellular Cl[-]. F14B8.2 F14B8.2 Protein of unknown function F14B8.3 F14B8.3 Member of the sugar (and other) transporter family, has weak similarity to a region of organic cationic transporter-like 1 (rat Orctl1), which mediates the exchange of organic anions, dicarboxylate, and para-aminohippurate F14B8.4 F14B8.4 Protein of unknown function F14B8.5 F14B8.5 Protein of unknown function, has strong similarity to C. elegans B0212.1 F14B8.6 F14B8.6 Protein of unknown function F14B8.7 F14B8.7 Putative ortholog of C. elegans B0212.1 gene product F14D12.1 F14D12.1 Protein with weak similarity to S. cerevisiae MUC1 (Cell surface flocculin, required for invasive and pseudohyphal growth) F14D12.2 unc-97;F14D12.2 Member of the PINCH family of LIM-only proteins; component of the integrin complex at hypodermal-muscle attachment sites LIM domain containing protein; The unc-97 gene encodes a LIM domain-containing protein of the PINCH family that is highly similar to human LIMS1 (OMIM:602567) and LIMS2; UNC-97 functions as an adaptor protein important for assembly of muscle adherens junctions and the mechanosensory functions of the touch neurons; UNC-97 interacts with PAT-4/integrin-linked kinase and with UNC-98; UNC-97 colocalizes with PAT-3/beta integrin at dense bodies, focal adhesion-like muscle attachment structures. F14D12.4 mec-2;F14D12.4 Protein required for chemotaxis and function of touch receptors The mec-2 gene encodes a stomatin homolog required to sense gentle mechanical stimuli (e.g. touch) along the body wall. F14D12.5 F14D12.5 Member of the sulfate transporter family, contains a sulphate transporter and antisigma factor antagonist (STAS) domain, which may bind NTPs, has low similarity to sulfate anion transporter 1 (rat Sat-1), which is a sulfate transporter sulfate transporter F14D12.6 F14D12.6 Member of the rhodopsin family of G protein-coupled receptors (GPCR), has low similarity to alpha-2A adrenergic receptor (human ADRA2A), which mediates action of epinephrine and norepinephrine and is involved in control of cell proliferation and shape G-protein coupled receptor F14D2.1 F14D2.1 Protein containing a BTB (BR-C, ttk and babor) or POZ (Pox virus and zinc finger) domain, which are found in some DNA and actin binding proteins and may mediate protein-protein interactions, has low similarity to uncharacterized C. elegans R52.1 F14D2.10 F14D2.10 Protein of unknown function, has high similarity to a region of C. elegans RSP-2, which is involved in mRNA splicing F14D2.11 F14D2.11 Member of the ubiquitin family F14D2.2 F14D2.2 Putative ortholog of C. elegans C41H7.5 gene product F14D2.3 F14D2.3 Protein with strong similarity to C. elegans F14D2.8 gene product F14D2.4 F14D2.4 Protein containing a BTB (BR-C, ttk and babor) or POZ (Pox virus and zinc finger) domain, which are found in some DNA and actin binding proteins, and a meprin and TRAF homology (MATH) domain, has moderate similarity to uncharacterized C. elegans C08C3.2 F14D2.5 F14D2.5 Protein of unknown function transposase F14D2.6 F14D2.6 Protein containing two DUF41 domains of unknown function, has low similarity to uncharacterized C. elegans K12D9.12 F14D2.7 F14D2.7 Protein with strong similarity to C. elegans F14H12.2 gene product F14D2.8 F14D2.8 Putative paralog of C. elegans F14D2.1 gene product This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins; this gene's encoded protein also contains an FTH/DUF38 motif, which may also mediate protein-protein interaction. F14D2.9 Tc8.1;F14D2.9 Putative transposase; has strong similarity to C. elegans C06A5.4 F14D7.1 F14D7.1 Protein with strong similarity to C. elegans C25G4.8 gene product F14D7.2 F14D7.2 Protein of unknown function F14D7.3 F14D7.3 Protein of unknown function, has weak similarity to C. elegans F36G9.12 F14D7.4 F14D7.4 Protein of unknown function, has moderate similarity to C. elegans F55G11.1 F14D7.5 F14D7.5 Protein of unknown function, has high similarity to uncharacterized C. elegans C55A1.4 F14D7.6 F14D7.6 Protein of unknown function, has high similarity to uncharacterized C. elegans T28C12.2 Multidrug resistance protein like F14D7.7 F14D7.7 Protein of unknown function, has high similarity to uncharacterized C. elegans C55A1.6 F14D7.8 F14D7.8 Protein of unknown function, has weak similarity to C. elegans F47B8.2 F14E5.1 F14E5.1 Member of the sugar (and other) transporter family, has low similarity to facilitative glucose transporter 3 (mouse Slc2a3), which is a high-affinity glucose transporter found predominantly in the brain that is required for blastocyst formation glucose transporter F14E5.2 F14E5.2 Protein containing 14 cysteine rich repeat domains, has low similarity to e-selectin ligand (mouse Sele1), which is a cysteine-rich membrane glycoprotein localized to the Golgi and plasma membranes that mediates leukocyte adhesion cysteine-rich fibroblast growth factor receptor F14E5.3 F14E5.3 Member of the histidine acid phosphatase family, which hydrolyze phosphate esters at low pH, has low similarity to rat Ppal, which is a prostatic acid phosphatase Histidine acid phosphatase F14E5.4 F14E5.4 Member of the histidine acid phosphatase family, which hydrolyze phosphate esters at low pH, has low similarity to human ACPP, which is a prostatic acid phosphatase that dephosphorylates the oncoprotein human ERBB2 and negatively regulates cell growth acid phosphatase F14E5.5 F14E5.5 Member of the class 2 lipase family, has moderate similarity to uncharacterized C. elegans C09E8.2 F14E5.6 F14E5.6 Putative ortholog of C. elegans F14E5.3 gene product Histidine acid phosphatase F14F11.1 nShaw1;F14F11.1 Putative voltage-gated potassium channel potassium channel F14F11.2 F14F11.2 Protein of unknown function F14F3.1 vab-3;lin-20;sax-4;F14F3.1 Homeodomain transcription factor required for morphogenesis of the head and gonad; similar over 430 amino acids to D. melanogaster PRD (paired) transcription factor and the human PAX6 paired box transcription factor 'Paired box' domain, homeobox protein (paired subfamily); The vab-3 gene (also known as mab-18) encodes an ortholog of human PAX6, which when mutated leads to aniridia (OMIM:106210). F14F3.2 F14F3.2 Protein containing two ankyrin (Ank) repeats, which may mediate protein-protein interactions, and a putative arf GTPase activation (GAP) domain, which have C-4 class zinc fingers, has low similarity to paxillin-kinase linker (human P95PKL) ankyrin motif F14F3.3 F14F3.3 Member of the membrane bound O-acyl transferase (MBOAT) family, which are found in acyltransferase enzymes, has weak similarity to uncharacterized C. albicans Orf6.7039p F14F4.1 F14F4.1 Member of the rhodopsin family of G protein-coupled receptors (GPCR), has low similarity to v1a vasopressin receptor (rat Avpr1a), which is a G protein-coupled receptor that mobilizes intracellular calcium through phosphoinositide hydrolysis 7 transmembrane receptor (rhodopsin family) F14F4.3 F14F4.3 Member of the ABC transporter family, contains three ABC transporter transmembrane domains, has moderate similarity to ATP-binding cassette subfamily C member 5 (human ABCC5), which is a transporter of organic anions and nucleotide analogs ABC transporter; The mrp-5 gene encodes a homolog of the human gene CFTR, which when mutated leads to cystic fibrosis (OMIM:219700). F14F7.1 F14F7.1 Protein with high similarity to C. elegans DPY-16, which is a putative collagen that functions in morphogenesis of the epithelium, contains a nematode cuticle collagen N-terminal domain collagen F14F7.2 F14F7.2 Member of the cytochrome P450 family, has low similarity to cytochrome P450 subfamily 3a polypeptide 9 (rat Cyp3a9), which is a sexually dimorphically expressed enzyme that demethylates erythromycin and benzphetamine cytochrome P450 F14F7.3 F14F7.3 Member of the cytochrome P450 family, has low similarity to cytochrome P450 subfamily 3a polypeptide 9 (rat Cyp3a9), which is a sexually dimorphically expressed enzyme that demethylates erythromycin and benzphetamine cytochrome P450 F14F7.4 F14F7.4 Protein of unknown function F14F7.5 F14F7.5 Protein of unknown function, has strong similarity to C. elegans W03F11.4 F14F8.1 F14F8.1 Member of the 7-transmembrane chemoreceptor family of G protein-coupled receptors (GPCR), has low similarity to C. elegans ODR-10, which is a G protein-coupled receptor involved in odorant response F14F8.2 F14F8.2 Member of an uncharacterized protein family F14F8.3 F14F8.3 Member of an uncharacterized protein family srz-1 encodes a predicted seven-pass G protein-coupled receptor; as loss of srz-1 activity via large-scale RNAi screens results in no obvious abnormalities, the precise role of SRZ-1 in C. elegans development and/or behavior is not yet known. F14F8.4 F14F8.4 Member of an uncharacterized protein family F14F8.5 F14F8.5 Protein of unknown function, has high similarity to uncharacterized C. elegans F14F8.6 7TM chemoreceptor, srw family F14F8.6 F14F8.6 Protein of unknown function, has high similarity to uncharacterized C. elegans F14F8.5 7TM chemoreceptor, srw family F14F8.7 F14F8.7 Protein of unknown function, has high similarity to uncharacterized C. elegans Y116F11B.5 7TM chemoreceptor, srw family F14F8.8 F14F8.8 Protein of unknown function F14F8.9 F14F8.9 Protein of unknown function, has weak similarity to C. elegans Y110A2A_54.L F14F9.1 F14F9.1 Member of the 7-transmembrane chemoreceptor family of G protein-coupled receptors (GPCR), has high similarity to uncharacterized C. elegans Y59A8B.4 7TM chemoreceptor, srh family F14F9.2 F14F9.2 Protein with weak similarity to S. cerevisiae MUC1 (Cell surface flocculin, required for invasive and pseudohyphal growth) F14F9.3 F14F9.3 Member of an uncharacterized protein family F14F9.4 F14F9.4 Protein of unknown function, has high similarity to uncharacterized C. elegans F14F9.3 F14F9.5 F14F9.5 Protein of unknown function F14F9.6 F14F9.6 Member of the retroviral aspartyl protease family, contains a zinc knuckle domain, which can bind RNA or DNA in eukaryotes, has strong similarity to uncharacterized C. elegans K02F6.1 F14F9.7 F14F9.7 Member of the 7-transmembrane chemoreceptor family of G protein-coupled receptors (GPCR), has high similarity to uncharacterized C. elegans Y47G7B.1 7TM chemoreceptor, srh family F14H12.1 F14H12.1 Protein with high similarity to C. elegans ROL-8, which is a putative collagen that functions in muscle development and cuticle synthesis, contains two collagen triple helix repeats and one nematode cuticle collagen N-terminal domain cuticular collagen F14H12.2 F14H12.2 Protein of unknown function, has moderate similarity to C. elegans F14D2.7 F14H12.3 F14H12.3 Protein containing three type 1 thrombospondin domains, has moderate similarity to a region of thrombospondin-1 (mouse Thbs1), which regulates cell attachment, spreading, migration,and proliferation and is an inhibitor of angiogenesis F14H12.4 F14H12.4 Protein with high similarity to serine threonine kinase 3 (human STK3), which is a protein kinase activated by cell stress that plays a role in apoptosis both upstream and downstream of caspase activation, contains two protein kinase domains protein kinase F14H12.6 F14H12.6 Protein of unknown function F14H12.7 F14H12.7 Protein of unknown function F14H12.8 F14H12.8 Protein of unknown function F14H3.1 F14H3.1 Member of the 7-transmembrane chemoreceptor family of G protein-coupled receptors (GPCR), has low similarity to C. elegans ODR-10, which is a G protein-coupled receptor involved in odorant response 7TM receptor F14H3.10 F14H3.10 Member of the cytochrome P450 family, has low similarity to cytochrome P450 subfamily 2b polypeptide 10 (mouse Cyp2b10), which is a phenobarbital-inducible type b estosterone 16 alpha-hydroxylase that is constitutively expressed in most females cytochrome P450 F14H3.11 F14H3.11 Protein containing a nuclear hormone receptor C4-type zinc finger domain, which bind DNA and may be involved in regulation of transcription, has a region of moderate similarity to a region of estrogen related receptor gamma (mouse Esrrg) Zinc finger, C4 type (two domains) F14H3.12 F14H3.12 Protein containing a C-terminal kinase associated domain 1, has high similarity to a region of C. elegans PAR-1, which is a serine/threonine protein kinase required for cytoplasmic partitioning during cleavage of early embryonic cells F14H3.2 F14H3.2 Member of the C. elegans putative membrane protein family 8, has low similarity to a region of bestrophin (human VMD2), which plays a role in vision and is associated with Bests disease, adult vitelliform macular dystrophy, and bull's eye maculopathy Putative membrane protein F14H3.3 F14H3.3 Protein with moderate similarity to C. elegans F14H3.5 F14H3.4 F14H3.4 Protein of unknown function, has moderate similarity to uncharacterized C. elegans F14H3.5 F14H3.5 F14H3.5 Protein of unknown function, has moderate similarity to uncharacterized C. elegans F14H3.4 F14H3.6 F14H3.6 Protein of unknown function F14H3.7 F14H3.7 Protein containing a DUF38 domain of unknown function and an F-box domain, which serve as a link between a target protein and a ubiquitin-conjugating enzyme, has a region of low similarity to C. elegans FOG-2 This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins; this gene's encoded protein also contains an FTH/DUF38 motif, which may also mediate protein-protein interaction. F14H3.8 F14H3.8 Protein containing a DUF38 domain of unknown function and an F-box domain, which serve as a link between a target protein and a ubiquitin-conjugating enzyme, has low similarity to uncharacterized C. elegans Y32B12C.3 F14H3.9 F14H3.9 Protein with strong similarity to C. elegans K03B4.6 gene product F14H8.1 F14H8.1 Member of the oxysterol-binding protein (OSBP) family, which are involved in sterol biosynthesis, has low similarity to human OSBPL2, which is a phosphatidylinositol binding protein oxysterol-binding protein F14H8.2 F14H8.2 Protein of unknown function, has weak similarity to C. elegans F14H8.5 F14H8.4 F14H8.4 Protein of unknown function, has high similarity to uncharacterized C. elegans F14H8.5 F14H8.5 F14H8.5 Protein of unknown function, has high similarity to uncharacterized C. elegans F14H8.4 F14H8.6 F14H8.6 Member of the cyclic nucleotide gated ion channel protein family CNG channel protein F15A2.1 F15A2.1 Protein containing two collagen triple helix repeats and one nematode cuticle collagen N-terminal domain, has low similarity to C. elegans MEC-5, which is a putative collagen involved in mechanosensory perception and defecation collagen F15A2.2 F15A2.2 Member of the trehalase family, which are O-glycosyl hydrolases, has low similarity to trehalase (human TREH), which catalyzes the hydrolysis of the disaccharide alpha, alpha-trehalose to yield two glucose subunits trehalase precursor F15A2.3 F15A2.3 Protein of unknown function, has low similarity to uncharacterized C. elegans F15A2.4 F15A2.4 F15A2.4 Protein of unknown function, has low similarity to uncharacterized C. elegans F15A2.3 F15A2.5 efn-3;F15A2.5 Protein with similarity to class A and B vertebrate Ephrins; it interacts with and weakly activates the VAB-1 receptor tyrosine kinase efn-3 encodes a potential GPI-modified ephrin that is, with EFN-2, is required for normal epidermal organization in the male tail; EFN-3, along with EFN-1 and EFN-2, activates the VAB-1 tyrosine kinase in vivo and binds it in vitro, and has a minor role in embryonic epiboly. F15A2.6 sad-1;F15A2.6 Serine/threonine protein kinase with similarity to human AMP-activated protein kinases and S. cerevisiae Snf1p and localizes to synapse-rich regions of the axon serine/threonine kinase (KIN1/SNF1/Nim1 subfamily); sad-1 encodes a novel serine/threonine protein kinase; SAD-1 activity is required for several aspects of presynaptic development, including termination of axon outgrowth and presynaptic vesicle clustering, in GABAergic motor neurons and the ASI amphid chemosensory neuron; in addition, overexpression studies suggest that SAD-1 may also play a role in regulating axonal-dendritic polarity; SAD-1 is expressed in the nervous system, where it localizes asymmetrically to the synapse-rich regions of axons. F15A2.7 F15A2.7 Protein of unknown function, has weak similarity to C. elegans F56H6.3 F15A4.1 F15A4.1 Member of the C. elegans Sre G protein-coupled chemoreceptor family, which are putative chemosensory receptors, has moderate similarity to uncharacterized C. elegans C50E10.10 7TM receptor, sre family F15A4.10 F15A4.10;2M776 Protein of unknown function F15A4.11 F15A4.11 Protein with weak similarity to D. melanogaster CG13404 (CG13404 gene product) F15A4.12 F15A4.12 Protein of unknown function F15A4.13 F15A4.13 Protein of unknown function, has moderate similarity to C. elegans F29A7.1 F15A4.2 F15A4.2 Protein containing an F-box domain, which serve as a link between a target protein and a ubiquitin-conjugating enzyme, has moderate similarity to uncharacterized C. elegans Y46G5A.7 This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins. F15A4.3 F15A4.3 Member of the C. elegans Sre G protein-coupled chemoreceptor family, which are putative chemosensory receptors, has high similarity to uncharacterized C. elegans Y57A10B.4 7TM receptor, sre family F15A4.4 F15A4.4 Member of the C. elegans Srg family of integral membrane proteins, which may be involved in chemosensation, has high similarity to uncharacterized C. elegans C34C6.1 G-protien coupled receptor, srg family F15A4.5 F15A4.5 Protein of unknown function 7TM receptor F15A4.6 F15A4.6 Member of an uncharacterized protein family Toxocara surface glycoprotein like F15A4.7 F15A4.7 Member of the C. elegans Srg family of integral membrane proteins, which may be involved in chemosensation, has high similarity to uncharacterized C. elegans F15A4.4 G-protein coupled receptor, srg family F15A4.8 F15A4.8 Member of the glycosyl hydrolase 18 family, has a region of weak similarity to chitinase 3-like 1 (cartilage glycoprotein-39, human CHI3L1), which is a chitin binding protein that lacks chitinase activity chitinase F15A4.9 F15A4.9 Protein of unknown function, has moderate similarity to C. elegans F35F10.11, ZK938.4, and T20D4.6 F15A8.1 F15A8.1 Protein of unknown function F15A8.2 F15A8.2 Protein of unknown function F15A8.4 F15A8.4 Protein with moderate similarity to C. elegans E04D5.2 gene product F15A8.5 CeDOP1;F15A8.5 Member of the rhodopsin family of G protein-coupled receptors (GPCR), has moderate similarity to dopamine D1 receptor (human DRD1), which is involved in behavior and renal control of blood pressure and is associated with addictive behaviors F15A8.6 F15A8.6 Member of the carboxylesterase type B family, has low similarity to esterase 1 (mouse Es1), which catalyzes the hydrolysis of a variety of esters including fatty acid esters of estradiol and activates the anticancer prodrug CPT 11 esterase F15A8.7 F15A8.7 Protein with moderate similarity to C. elegans W02B8.3 gene product F15B10.1 F15B10.1 Protein containing one uncharacterized domain DUF6, has low similarity to S. cerevisiae Yea4p, which is an UDP-N-acetylglucosamine transporter The F15B10.1 gene encodes an ortholog of the Kluyveromyces lactis UDP-N-acetylglucosamine (UPD-GlcNAc) transporter; when expressed in human cells deficient for GDP-fucose transport into the Golgi, F15B10.1 is able to weakly restore such transport (with ~10% efficiency). F15B10.2 F15B10.2 Member of the DEAD or DEAH box ATP-dependent RNA helicase family and contains a helicase conserved C-terminal domain, has a region of low similarity to a region of C. elegans DCR-1, which is a helicase and RNase that functions in the production of stRNAs This gene encodes a protein predicted by Eisenberg and coworkers, with 52% accuracy, to be mitochondrial. F15B10.3 F15B10.3 Protein of unknown function, has high similarity to uncharacterized C. elegans F38A5.7 F15B9.1 F15B9.1 Member of an uncharacterized protein family O.volvulus antigen peptide like F15B9.2 F15B9.2 Protein of unknown function, has moderate similarity to uncharacterized C. elegans F15B9.1 O.volvulus antigen peptide like; far-4 encodes a fatty acid and retinol-binding protein, paralogous to FAR-3 and FAR-5 and distantly homologous to FAR proteins of parasitic nematodes; FAR-4 binds lipids in vitro; far-4 is transcribed at highest levels in the fourth larval stage, and is dispensable for viability and gross morphology in mass RNAi assays. F15B9.3 F15B9.3 Protein containing a delta serrate ligand (DSL) domain, has a region of low similarity to a region of C. elegans LAG-2, which appears to interact with C. elegans LIN-12 and C. elegans GLP-1 Notch receptors to influence cell fate decisions far-5 encodes a member of a class of fatty acid-and retinol-binding proteins that are known to be secreted by parasitic nematodes and plants; far-5 binds lipid in fluorescence-based assays, however, the precise function of far-5 is not known. F15B9.4 F15B9.4 Protein containing a formin homology 2 domain, which are found in proteins that control rearrangements of the actin cytoskeleton F15B9.5 F15B9.5 Protein with moderate similarity to C. elegans Y12A6A.1 gene product F15B9.6 F15B9.6 Protein of unknown function, has weak similarity to C. elegans F35C11.5 phospholipase A2 F15B9.7 cdh-6;F15B9.7 Protein containing eight cadherin, two epidermal growth factor (EGF)-like, extracellular laminin G, latrophilin or CL-1-like GPS, and hormone receptor domains, has low similarity to cadherin EGF LAG seven-pass G-type receptor (mouse Celsr1) cadherin; cdh-6 encodes a cadherin homolog, with a domain resembling seven transmembrane-sequence receptors, that may be orthologous to the Drosophila cadherin STAN; both CDH-6 and STAN are homologous to secretin-type receptors, have extracellular domains of similar lengths and domain compositions (with similar numbers of cadherin, EGF, laminin G, GFS, and HormR domains); however, the cytoplasmic domains of CDH-6 and STAN are dissimilar. F15B9.8 F15B9.8 Protein that has putative thrombospondin type 1 domain Thrombospondin type 1 domain F15C11.1 sem-4;F15C11.1 Putative transcription factor required for specification of diverse cell fates Zinc finger, C2H2 type (7 domains) F15C11.2 F15C11.2 Member of the ubiquitin family, contains a UBA (ubiquitin associated) or TS-N domain, has moderate similarity to ubiquilin 1 (mouse Ubqln1), which is a ubiquitin-related protein involved in cytoskeleton organization and biogenesis Ubiquitin family F15D3.1 dys-1;F15D3.9;F32B4.3;F15D3.1 Ortholog of human dystrophin dystrophin; The dys-1 gene encodes an ortholog of human DMD, which when mutated leads to Duchenne muscular dystrophy (OMIM:310200). F15D3.2 F15D3.2 Member of the C-type lectin protein family Lectin C-type domain short and long forms, von Willebrand factor type A domain F15D3.3 F15D3.3 Protein containing collagen triple helix repeats, has a region of moderate similarity to a region of C. elegans BLI-1, which is a putative collagen that is involved in embryogenesis and histogenesis and chemotaxis F15D3.4 F15D3.4 Putative ortholog of C. elegans F44G3.7 gene product F15D3.5 F15D3.5 Protein of unknown function F15D3.6 F15D3.6 Protein of unknown function, has moderate similarity to uncharacterized human C20ORF45 F15D3.7 F15D3.7 Protein of unknown function, has a region of low similarity to translocase of inner mitochondrial membrane 23 homolog (rat Timm23), which translocates nuclear-encoded proteins into the mitochondrial matrix F15D3.8 F15D3.8 Protein with weak similarity to S. cerevisiae GLE1 (RNA export mediator) F15D4.1 F15D4.1 Protein containing two SNF2 related N-terminal domains and a helicase conserved C-terminal domain, has low similarity to TBP-associated factor 172 (human BTAF1), which is involved in regulation RNA polymerase II and RNA polymerase III transcription helicase; btf-1 encodes a member of the TBP-associated family (TAF), with weak similarity to human TBP-associated factor 172. F15D4.2 F15D4.2 Protein of unknown function F15D4.3 F15D4.3 Protein of unknown function, has moderate similarity to C. elegans F36F12.4 F15D4.4 F15D4.4 Member of the papain family of cysteine proteases, has a region of low similarity to cathepsin S (human CTSS), which is an endosomal and lysosomal cysteine protease that has elastinolytic activity and may mediate inflammatory and immune responses cysteine protease F15D4.5 F15D4.5 Putative paralog of C. elegans C38D9.2 gene product F15D4.6 F15D4.6 Protein of unknown function F15D4.7 F15D4.7 Protein containing a retroviral integrase core domain, which are the central catalytic domains that can act as endonucleases, has moderate similarity to uncharacterized C. elegans ZK228.2 F15E11.13 F15E11.13 Putative ortholog of C. elegans Y19D10B.7 gene product F15E11.14 F15E11.14 Putative ortholog of C. elegans F15E11.1 gene product F15E6.1 F15E6.1 Protein with weak similarity to C. elegans lin-36 (Part of the class B pathway that antagonizes vulval induction) F15E6.2 F15E6.2 Protein of unknown function, has weak similarity to uncharacterized C. elegans C33G3.3 F15E6.3 F15E6.3 Protein of unknown function, has weak similarity to C. elegans F15E6.4 F15E6.4 F15E6.4 Protein of unknown function, has weak similarity to C. elegans F15E6.8 F15E6.5 F15E6.5 Protein of unknown function, has weak similarity to C. elegans C33F10.8 F15E6.6 F15E6.6 Protein containing one molybdopterin binding, one [2Fe-2S] binding, one a-b hammerhead, and one 2Fe-2S iron-sulfur cluster binding domain, has low similarity to xanthine dehydrogenase (rat Xdh), which converts xanthine to uric acid in purine catabolism xanthine dehydrogenase F15E6.7 F15E6.7 Protein with similarity to G protein-coupled receptors of the SRG subfamily, no homolog found in human or D. melanogaster, may have fewer than 7 predicted transmembrane domains 7TM chemoreceptor, srv family F15E6.8 F15E6.8 Protein of unknown function, has weak similarity to C. elegans F15E6.4 F15E6.9 F15E6.9 Protein of unknown function F15G9.1 F15G9.1 Protein of unknown function F15G9.2 F15G9.2 Protein of unknown function F15G9.3 F15G9.3 Protein of unknown function F15G9.4 F15G9.4 Putative ortholog of C. elegans unc-89 gene product IG (immunoglobulin) superfamily (47 domains); The him-4 gene encodes a large (5198-residue) extracellular protein, called 'hemicentin', that belongs to the immunoglobulin superfamily. F15G9.5 F15G9.5 Protein of unknown function that may be anchored to the membrane of a secretory vesicle or the Golgi apparatus F15H10.1 col-12;F15H10.1 Collagen of the collagen triple helix repeat (20 copies) family, putative paralog of C. elegans col-13 gene product collagen; col-12 encodes a member of the collagen superfamily containing collagen triple helix repeats (20 copies); expressed throughout development but expression peaks after each larval molt when new cuticle is being secreted and deposited, and after the L4 to adult larval molt. F15H10.2 col-13;F15H10.2 Collagen of the collagen triple helix repeat (20 copies) family, putative paralog of C. elegans col-12 gene product collagen; col-13 encodes a collagen which is expressed in all stages of development, like sqt-3 (col-1), col-3, col-10, col-11, col-12, and col-14; collagen genes with this expression profile may be specifically required to construct the L1 cuticle (and, perhaps, less specifically required for cuticles at other stages); the amino- and carboxyl-terminal cysteine-rich regions of COL-13 are most closely related to those of COL-6, COL-12, COL-14, COL-36, and COL-40. F15H10.3 apc-10;F15H10.3 Protein with low similarity to anaphase promoting complex (APC) subunit 10 (human APC10), which regulates mitotic G1-S transition and may target human CDK2 for proteasome-mediated degradation and is associated with malignant oral tumors Yeast hypothetical protein like; apc-10 encodes a homolog of the fission yeast anaphase promoting complex subunit APC10; apc-10(RNAi) animals are generally unable to progress through meiotic divisions; initially they produce reduced numbers of viable embryos mixed with inviable embryos, but then show severe germline maintenance defects and become sterile. F15H10.4 F15H10.4 Member of the transmembrane amino acid transporter (permease) family, has a region of weak similarity to a region of S. cerevisiae Yjr001p, which is involved in vacuolar uptake of the large neutral amino acids tyrosine, glutamine, and isoleucine F15H10.5 F15H10.5 Protein of unknown function, has moderate similarity to C. elegans D1005.5 F15H10.6 F15H10.6 Protein of unknown function, has low similarity to uncharacterized C. elegans D1005.5 F15H10.7 F15H10.7 Member of a protein family F15H10.8 F15H10.8 Protein of unknown function, has moderate similarity to C. elegans T15D6.11 F15H9.1 F15H9.1 Protein of unknown function, has strong similarity to C. elegans F35E2.5 F15H9.2 F15H9.2 Member of the 7-transmembrane chemoreceptor family of G protein-coupled receptors (GPCR), has high similarity to uncharacterized C. elegans F15H9.4 7TM chemoreceptor, sri family F15H9.3 F15H9.3 Member of the 7-transmembrane chemoreceptor family of G protein-coupled receptors (GPCR), has high similarity to uncharacterized C. elegans F15H9.4 7TM chemoreceptor, sri family F15H9.4 F15H9.4 Member of the 7-transmembrane chemoreceptor family of G protein-coupled receptors (GPCR), has high similarity to uncharacterized C. elegans F15H9.3 7TM chemoreceptor, sri family F16A11.1 F16A11.1 Protein containing a C3HC4-type (RING finger) zinc finger domain and a SPRY (SPla, RYanodine Receptor) domain Zinc finger, C3HC4 type (RING finger) F16A11.2 F16A11.2 Member of the uncharacterized protein family UPF0027, has high similarity to uncharacterized human HSPC117 Methanococcus hypothetical protein 0682 like F16A11.3 F16A11.3 Protein of unknown function F16B12.1 F16B12.1 Protein containing a CUB domain, which occurs extracellularly often in developmentally regulated proteins, has weak similarity to uncharacterized C. elegans F38B2.3 C1R/C1S-like domain F16B12.2 F16B12.2 Protein containing three epidermal growth factor (EGF)-like domains, has low similarity to a region of C. elegans APX-1, which is a ligand for the GLP-1 receptor and induces the ABp cell fate APX-1 like protein F16B12.4 F16B12.4 Protein with moderate similarity to C. elegans T03D3.5 gene product F16B12.5 F16B12.5 Protein containing a protein kinase domain, has a region of low similarity to a region of casein kinase 1 epsilon (mouse Csnk1e), which is a putative serine/threonine protein kinase with broad substrate specificity that may function in DNA repair serine/threonine kinase F16B12.6 F16B12.6 Putative ortholog of C. elegans Y48G1C.8 gene product F16B12.7 F16B12.7 Protein of unknown function, has low similarity to uncharacterized C. elegans K08H2.5 serine/threonine kinase F16B12.8 F16B12.8 Protein containing a nuclear hormone receptor ligand-binding domain, has moderate similarity to a region of C. elegans NHR-51, which is involved in developmental processes Ligand-binding domain of nuclear hormone receptors F16B3.1 egl-2;F16B3.1 Voltage-gated potassium channel, has strong similarity to Drosophila ether-a-go-go (eag) potassium channel channel protein; egl-2 encodes a voltage-gated potassium channel that affects egg laying, muscle activation, defecation, mechanosensation, and chemosensation; expressed in the intestinal muscle, AFD, ALN, AQR, ASE, AWC, BAG, IL2, PLN, PQR, and URX neurons as well as a subset of sensory neurons in the male tail. F16B3.2 F16B3.2 Protein with moderate similarity to C. elegans R08F11.7 gene product F16B4.1 F16B4.1 Member of the nuclear hormone receptor/Zinc finger protein family zinc finger protein F16B4.10 F16B4.10 Protein containing two DUF40 domains of unknown function, which contain four conserved cysteines, has low similarity to uncharacterized C. elegans C45H4.16 F16B4.11 F16B4.11 Protein containing a nuclear hormone receptor C4-type zinc finger domain, which bind DNA and may be involved in regulation of transcription, has low similarity to C. elegans NHR-58 zinc finger protein F16B4.12 F16B4.12 Protein containing two nuclear hormone receptor C4-type zinc finger domains, which bind DNA and may be involved in regulation of transcription, has low similarity to C. elegans NHR-58, which is involved in embryogenesis and morphogenesis zinc finger protein F16B4.2 F16B4.2 Protein containing an F-box domain, which serve as a link between a target protein and a ubiquitin-conjugating enzyme, has low similarity to uncharacterized C. elegans Y17G7B.8 This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins. F16B4.3 F16B4.3 Protein of unknown function, has low similarity to uncharacterized C. elegans T07F8.1 F16B4.4 F16B4.4 Protein of unknown function F16B4.5 F16B4.5 Protein of unknown function F16B4.6 F16B4.6 Protein containing a phosphopantetheine attachment site domain acy carrier protein; This gene encodes a protein predicted by Eisenberg and coworkers, with 52% accuracy, to be mitochondrial. F16B4.7 F16B4.7 Protein of unknown function F16B4.8 F16B4.8 Protein containing a rhodanese-like domain, has low similarity to C. elegans K06A5.7, which is involved in cell division protein-tyrosine phosphatase; cdc-25.2 encodes a putative homolog of Cdc25 phosphatase protein family that affects germline proliferation. F16B4.9 F16B4.9 Protein containing two nuclear hormone receptor C4-type zinc finger domains and a nuclear hormone receptor ligand-binding domain, has low similarity to C. elegans NHR-58, which is involved in embryogenesis and morphogenesis nuclear hormone receptor F16C3.1 F16C3.1 Member of the rhodopsin family of G protein-coupled receptors (GPCR), has low similarity to uncharacterized C. elegans C24B5.1 7TM receptor F16C3.2 F16C3.2 Protein of unknown function, has low similarity to C. elegans C35C5.8 F16D3.1 F16D3.1 Protein with strong similarity to keratinocyte alpha-tubulin (human K-ALPHA-1), which may contribute to antimitotic drug resistance, member of the tubulin-FtzA family, which are involved in polymer formation tubulin; tba-5 encodes one of nine C. elegans alpha tubulins; by homology, TBA-5 is predicted to be a component of microtubules; as loss of tba-5 function via RNA-mediated interference (RNAi) does not result in any obvious abnormalities, TBA-5 likely functions redundantly with other alpha tubulins as a basic component of cellular architecture that may play additional roles in processes such as cell division, cell movement, and intracellular transport. F16D3.2 F16D3.2 Protein containing a tudor domain, which are found in proteins involved in RNA localization F16D3.4 F16D3.4 Protein with low similarity to S. pombe Alp1p, which is required for alpha- and beta-tubulin folding F16D3.4 encodes an ortholog of human TUBULIN-SPECIFIC CHAPERONE D (TBCD; OMIM:604649), also known as tubulin-folding cofactor D; F16D3.4 may be a ligand and effector of the ARL2 ortholog EVL-20. F16D3.5 F16D3.5 Member of the transposase family, which are required for excising and inserting mobile genetic elements, has very strong similarity to uncharacterized C. elegans ZK546.8 transposase F16D3.6 F16D3.6 Protein of unknown function, has strong similarity to uncharacterized C. elegans B0546.5 F16D3.7 F16D3.7 Member of the rhodopsin family of G protein-coupled receptors (GPCR), has low similarity to adrenergic receptor alpha 1c (rat Adra1c), which regulates cell proliferation and muscle contraction and represents the pharmacologically defined alpha 1A receptor 7 transmembrane receptor (rhodopsin family) (2 domains) F16F9.1 F16F9.1 Protein of unknown function, has weak similarity to C. elegans Y37D8A.6 F16F9.2 F16F9.2 Protein of unknown function, has a region of weak similarity to a region of nascent-polypeptide-associated complex alpha subunit (mouse Naca), which binds JUN and enhances JUN-mediated transcription and functions in myogenesis dpy-6 was identified in screens for recessive mutations that affect body morphology; dpy-6 mutations result in animals that are smaller and stouter than wild type; the molecular identity of dpy-6 is not yet known. F16F9.3 F16F9.3 Protein of unknown function F16F9.4 F16F9.4 Protein with low similarity to arylacetamide deacetylase (human AADAC), which is an esterase involved in the metabolic activation of arylamine carcinogens lipase F16F9.5 mec-10;F16F9.5 Member of the amiloride-sensitive sodium channel family, member of degenerin family and DEG/ENaC superfamily of proteins degenerin; The mec-10 gene encodes an amiloride-sensitive Na+ channel protein (degenerin) required to sense gentle mechanical stimuli (e.g. touch) along the body wall; it is paralogous to mec-4, which has similar function in vivo. F16G10.1 F16G10.1 Protein containing a DUF130 domain of unknown function, has high similarity to uncharacterized C. elegans F16G10.13 F16G10.10 F16G10.10 Protein containing a DUF130 domain of unknown function F16G10.11 F16G10.11 Protein containing a DUF130 domain of unknown function, has strong similarity to uncharacterized C. elegans F47B7.4 F16G10.13 F16G10.13 Protein containing a DUF130 domain of unknown function, has high similarity to uncharacterized C. elegans F47B7.5 F16G10.14 F16G10.14 Protein containing two DUF130 domains of unknown function, has low similarity to uncharacterized C. elegans F43C11.11 F16G10.15 F16G10.15 Member of an uncharacterized protein family F16G10.2 F16G10.2 Protein containing a DUF130 domain of unknown function, has moderate similarity to uncharacterized C. elegans F16G10.4 F16G10.3 F16G10.3 Protein containing a DUF130 domain of unknown function, has moderate similarity to uncharacterized C. elegans F16G10.4 F16G10.4 F16G10.4 Protein containing a DUF130 domain of unknown function, has moderate similarity to uncharacterized C. elegans F16G10.9 F16G10.5 F16G10.5 Protein containing a PDZ, DHR, or GLGF domain, which are found in signaling proteins F16G10.6 F16G10.6 Protein containing a DUF130 domain of unknown function, has moderate similarity to uncharacterized C. elegans F16G10.2 F16G10.7 F16G10.7 Protein containing a DUF130 domain of unknown function, has moderate similarity to uncharacterized C. elegans F16G10.4 F16G10.8 F16G10.8 Protein containing a DUF130 domain of unknown function, has high similarity to uncharacterized C. elegans F16G10.9 F16G10.9 F16G10.9 Protein containing a DUF130 domain of unknown function, has high similarity to uncharacterized C. elegans F16G10.8 F16H11.1 F16H11.1 Protein of unknown function F16H11.2 F16H11.2 Protein of unknown function F16H11.3 F16H11.3 Member of the nucleoside transporter family, has weak similarity to solute carrier family 29 member 1 (human SLC29A1), which functions in the transport of physiologic nucleosides and chemotherapeutic nucleoside analog drugs F16H11.4 ceh-1;F16H11.4 Homeodomain transcription factor, has similarity over the homeodomain to many human and D. melanogaster homeodomain transcription factors ceh-1 encodes a protein that contains a homeobox domain. F16H11.5 nhr-45;F16H11.5 Protein with weak similarity to C. elegans nhr-2 (Putative nuclear hormone receptor required for embryogenesis) zinc finger DNA-binding protein F16H6.1 F16H6.1 Member of the C-type lectin protein family Lectin C-type domain short and long forms, CUB domain F16H6.10 F16H6.10 Protein with strong similarity to C. elegans F57G4.1 gene product F16H6.2 F16H6.2 Member of the C-type lectin family, has weak similarity to human early T-cell activation antigen CD69 C-type lectin domain F16H6.3 F16H6.3 Protein containing a DUF18 domain of unknown function, has high similarity to uncharacterized C. elegans F26D2.13 F16H6.4 F16H6.4 Protein of unknown function, has high similarity to uncharacterized C. elegans F16H6.7 F16H6.5 F16H6.5 Protein of unknown function, has high similarity to uncharacterized C. elegans F16H6.7 F16H6.6 F16H6.6 Protein of unknown function F16H6.7 F16H6.7 Protein of unknown function, has high similarity to uncharacterized C. elegans F16H6.5 F16H6.8 F16H6.8 Protein of unknown function, has high similarity to uncharacterized C. elegans F16H6.9 F16H6.9 F16H6.9 Protein of unknown function, has high similarity to C. elegans F16H6.8 F16H9.1 rgs-2;F16H9.1 Member of the regulator of G protein signaling domain protein family, modulates resumption of egg-laying after starvation Regulator of G protein signalling domain; rgs-2 encodes a regulator of G protein signaling; by homology, RGS-2 is predicted to function as a GTPase-activating protein for heterotrimeric G-protein alpha-subunits, and in vitro RGS-2 can stimulate the GTPase activity of purified GOA-1; in vivo, rgs-2 appears to function redundantly with rgs-1 to regulate egg-laying behavior when animals are refed following starvation; rgs-2 is expressed in pharyngeal and uterine muscles and in a subset of neurons, including neurons in the ventral cord and head- and tail-ganglia. F16H9.2 F16H9.2 Protein containing a nuclear hormone receptor ligand-binding domain, has low similarity to C. elegans NHR-51, which is involved in developmental processes Ligand-binding domain of nuclear hormone receptors, Zinc finger, C4 type (two domains) F17A2.1 trx-2;F17A2.1 Protein with moderate similarity to C. elegans trx-1 gene product TRA-2 like protein; xtr-2 encodes a protein with similarity to TRA-2A and TRA-2B in a region known as the MX region, hypothesized to be a protein-protein interaction domain involved in negatively regulating tra-2 activity in the germ line. F17A2.10 F17A2.10 Protein of unknown function, has high similarity to uncharacterized C. elegans F17A2.11, which is predicted to be a G protein-coupled receptor F17A2.11 F17A2.11 Protein of unknown function, has high similarity to uncharacterized C. elegans F17A2.9 F17A2.12 F17A2.12 Protein of unknown function, has high similarity to uncharacterized C. elegans F17A2.6 F17A2.13 F17A2.13 Protein of unknown function F17A2.3 F17A2.3 Protein containing a PHD-finger, which may be involved in chromatin-mediated transcriptional regulation, has weak similarity to uncharacterized C. elegans K09A11.5 PHD-finger. F17A2.4 F17A2.4 Protein of unknown function F17A2.5 ceh-40;F17A2.5 Protein containing a homeobox domain (homeodomain), which are found in transcription factors, has moderate similarity to C. elegans CEH-20, which is a homeodomain transcription factor Homeobox domain; a homeodomain protein homologous to Extradenticle (Exd) from Drosophila, genetically interacts with ceh-20. F17A2.6 F17A2.6 Protein of unknown function, has high similarity to uncharacterized C. elegans F17A2.12 F17A2.7 F17A2.7 Protein of unknown function, has high similarity to uncharacterized C. elegans F17A2.11 F17A2.8 F17A2.8 Protein of unknown function, has high similarity to uncharacterized C. elegans R04D3.9 F17A2.9 F17A2.9 Protein of unknown function, has high similarity to uncharacterized C. elegans F17A2.11 F17A9.1 F17A9.1 Protein containing a DUF38 domain of unknown function, has low similarity to C. elegans T07D3.1, which plays a role in positive regulation of body size and gametogenesis and may function in germ-line stem cell differentiation F17A9.1 encodes a divergent ONECUT class CUT homeobox protein with a single N-terminal cut domain; F17A9.1 has an atypical tyrosine residue at position 48 of its homeodomain rather than a phenylalanine or tryptophan residue; the cut domain may be a compact DNA-binding domain composed of alpha helices; phylogenetically, F17A9.1 is (somewhat distantly) affiliated with C17H12.9, Drosophila ONECUT, and mammalian HNF6 proteins; F17A9.1 has no obvious function in mass RNAi assays. F17A9.2 F17A9.2 Protein of unknown function, has moderate similarity to uncharacterized human FLJ10998 F17A9.3 F17A9.3 Protein containing a bZIP (basic-leucine zipper) transcription factor domain BZIP transcription factor F17A9.4 F17A9.4 Protein with similarity to NADH oxidases; has very high similarity to a number of C. elegans proteins F17A9.5 F17A9.5 Protein with similarity to NADH oxidases, has very high similarity to a number of C. elegans proteins F17A9.6 F17A9.6 Protein containing a homeobox domain (homeodomain), which are found in transcription factors, and a CUT domain, which binds DNA, has a region of low similarity to a region of one cut domain family member 2 (human ONECUT2), which is a transcription factor homeobox protein; F17A9.6 encodes a divergent ONECUT class CUT homeobox protein with a single N-terminal cut domain; F17A9.6 has an atypical tyrosine residue at position 48 of its homeodomain rather than a phenylalanine or tryptophan residue; the cut domain may be a compact DNA-binding domain composed of alpha helices; phylogenetically, F17A9.6 is (somewhat distantly) affiliated with C17H12.9, Drosophila ONECUT, and mammalian HNF6 proteins; F17A9.6 has no obvious function in mass RNAi assays. F17B5.1 F17B5.1 Protein of unknown function, has a region of moderate similarity to C. elegans R05H5.3, which is a putative nuclear thioredoxin involved in embryogenesis and morphogenesis F17B5.2 F17B5.2 Protein containing a C-type lectin domain and a DUF33 domain of unknown function, has high similarity to uncharacterized C. elegans F37C4.2 Lectin C-type domain F17B5.3 F17B5.3 Protein of unknown function, has high similarity to uncharacterized C. elegans Y18D10A.10 F17B5.4 F17B5.4 Member of the glycosyl transferase family 11, which hydrolyze the glycosidic bond between two or more carbohydrates F17B5.5 F17B5.5 Member of the C-type lectin family F17C11.1 F17C11.1 Protein of unknown function, has weak similarity to C. elegans W07G1.C F17C11.10 F17C11.10 Putative ortholog of human AND-1 protein (Hs.72160), a DNA-binding protein containing both WD-repeats and an HMG box sepB domain F17C11.11 F17C11.11 Protein with strong similarity to C. elegans C45B11.2 gene product F17C11.12 F17C11.12 Putative ortholog of C. elegans Y51A2D.18 gene product F17C11.2 F17C11.2 Protein with moderate similarity to C. elegans C07B5.3 gene product F17C11.3 F17C11.3 Protein containing two collagen triple helix repeats and one nematode cuticle collagen N-terminal domain, has moderate similarity to C. elegans ROL-6, which is a putative collagen that functions in morphogenesis of the epithelium and cuticle synthesis collagen F17C11.4 F17C11.4 Protein of unknown function F17C11.5 F17C11.5 Protein containing a C-type lectin domain, which mediate calcium-dependent carbohydrate recognition F17C11.6 F17C11.6 Protein of unknown function F17C11.7 F17C11.7 Protein of unknown function, has low similarity to uncharacterized human LOC51604 F17C11.8 F17C11.8 Protein of unknown function, has moderate similarity to uncharacterized human LOC51028 F17C11.9 F17C11.9 Protein with high similarity to eukaryotic elongation factor 1 gamma (human EEF1G), which is a likely translation EF-1 complex component, contains an elongation factor 1 gamma conserved domain and a glutathione S-transferase C-terminal domain elongation factor 1-gamma F17C8.1 acy-1;sgs-1;F17C8.1 Putative adenylyl cyclase which plays a role in neuronal degeneration adenylate cyclase; The acy-1 gene encodes a protein with 40% identity to mammalian adenylyl cyclases, most closely related to the divergent mouse isoform type IX, that affects viability, muscle contraction, locomotion, and molting; it acts genetically downstream of gsa-1 and is expressed in excitable cells. F17C8.2 F17C8.2 Protein containing two collagen triple helix repeats and one nematode cuticle collagen N-terminal domain, has high similarity to a region of C. elegans BLI-1, which is a putative collagen that is involved in embryogenesis and morphogenesis and chemotaxis cuticular collagen F17C8.3 F17C8.3 Protein containing a DUF108 domain of unknown function F17C8.4 ras-2;Ras2;F17C8.4 Protein with high similarity to muscle microspikes RAS (human MRAS), which is involved in the reorganization of the actin cytoskeleton and induces cellular transformation, member of the Ras superfamily of GTP-binding proteins Ras-like protein F17C8.5 twk-5;F17C8.5 Member of the 4 TM potassium channel protein family twk-6 encodes one of 44 C. elegans TWK (two-P domain K+) potassium channel subunits that contain two pore-forming domains and four transmembrane domains; as loss of TWK-6 function via RNA-mediated interference (RNAi) does not result in any abnormalities, the precise role of TWK-6 in C. elegans development and/or behavior is not yet known; TWK-6 may, however, function redundantly with other TWK channels; TWK-6 is expressed in the hypodermis. F17C8.6 F17C8.6 Protein of unknown function, has high similarity to uncharacterized C. elegans C11D2.5 F17E5.1 lin-2;F17E5.1 Component of the LIN-2, LIN-7, LIN-10 cell junction complex, involved in vulval development, probable ortholog of human and rat CASK proteins (putative scaffold proteins of the cytoskeletal membrane involved in signal transduction coordination) MAGUK protein, calcium/calmodulin dependent protein kinase; lin-2 encodes a protein belonging to the membrane associated guanylate kinase (MAGUK) family, with several domains (L27, PDZ, SH3, and guanylate kinase) thought to assemble specific multiprotein complexes in particular regions of the cell; in vivo, LIN-2 is required for the correct localization of LET-23 (and, presumably, other membrane proteins) to specific regions of the plasma membrane. F17E5.2 F17E5.2 Member of the mitochondrial carrier (MCF) protein family, has similarity to H. sapiens MCF family member Aralar which binds calcium ADP/ATP carrier protein F17E9.1 F17E9.1 Protein containing two collagen triple helix repeats and one nematode cuticle collagen N-terminal domain, has low similarity to C. elegans MEC-5, which is a putative collagen that functions in mechanosensory perception and defecation F17E9.10 his-32;F17E9.10 Member of the histone H3 protein family histone H3; his-32 encodes an H3 histone; by homology, HIS-32 is predicted to function as a nucleosome component required for packaging of DNA into chromatin; his-32 is a replication-dependent histone locus that resides in the HIS5 cluster on chromosome IV. F17E9.11 F17E9.11 Member of an uncharacterized protein family with similarity to Entemeba histolytica lysozymes F17E9.12 his-31;F17E9.12 Protein with very strong similarity to H4 histone family member E (human H4FE), which may play a role in the establishment and/or maintenance of chromatin architecture in nucleosomes, member of the histone family of nucleosomal core proteins his-31 encodes an H4 histone; his-31 is contained within the histone gene cluster HIS5. F17E9.13 his-33;F17E9.13 Protein with very strong similarity to C. elegans HIS-16, member of the histone family of nucleosomal core proteins his-33 encodes an H2A histone; by homology, HIS-33 is predicted to function as a nucleosome component required for packaging of DNA into chromatin; his-33 is a replication-dependent histone locus that resides in the HIS5 cluster on chromosome IV. F17E9.2 F17E9.2 Protein with moderate similarity to C. elegans F17E9.4 gene product F17E9.3 F17E9.3 Protein of unknown function, has moderate similarity to uncharacterized C. elegans F17E9.4 F17E9.4 F17E9.4 Protein of unknown function, has moderate similarity to uncharacterized C. elegans D2096.10 F17E9.5 F17E9.5 Protein of unknown function, has strong similarity to uncharacterized C. elegans Y38C1AA.7 F17E9.7 F17E9.7 Protein containing a neurotransmitter-gated ion-channel ligand binding domain, has low similarity to a region of neuronal nicotinic acetylcholine receptor alpha 6 subunit (human CHRNA6), which may be involved in neural synaptic transmission F17E9.8 F17E9.8 Protein containing a neurotransmitter-gated ion-channel ligand binding domain, has weak similarity to 5-hydroxytryptamine (serotonin) 3B receptor subunit (human HTR3B), which is a component of brain serotonin-gated cation channels F17E9.9 his-34;his-11;F17E9.9 Protein with strong similarity to H2B histone family member R (human H2BFR), which is a component of nucleosomes along with core histones H2A, H3, H4, and DNA, member of the histone family of nucleosomal core proteins histone 2B; his-34 encodes an H2B histone; his-34 is contained within the histone gene cluster HIS5. F17H10.1 F17H10.1 Protein of unknown function F17H10.2 F17H10.2 Protein of unknown function, has weak similarity to C. elegans C39D10.6 F17H10.3 F17H10.3 Protein containing a phox protein (PX) domain, which bind phosphoinositides, has low similarity to uncharacterized human SNX17 PhoX homologous domain, present in p47phox and p40phox. F17H10.4 F17H10.4 Protein of unknown function F18A1.1 F18A1.1 Protein of unknown function F18A1.2 lin-26;F18A1.2 Zinc-finger transcription factor required for the specification of non-neuronal ectodermal cell fates transcription factor; lin-26 encodes a putative C2H2 zinc finger-containing protein required for proper differentiation of ectodermal and mesodermal epithelial cells; LIN-26 is expressed in many different cell types including the rectal rep cells, the somatic gonad, glial cells, and hypodermal cells; ectopic LIN-26 expression during embryogenesis induces epithelial-like cell fates suggesting that LIN-26 is sufficient for epithelial differentiation. F18A1.3 lir-1;F18A1.3 Putative transcription factor related to LIN-26 LIR-1 has no obvious effect on development when ectopically expressed in embryos, despite having a primary sequence closely similar to that of LIN-26. F18A1.4 lir-2;F18A1.4 Putative transcription factor related to LIN-26 contains C2H2-type zinc finger F18A1.5 F18A1.5 Protein containing an OB-fold nucleic acid binding domain, has low similarity to replication protein A1 70 kDa (human RPA1), which is a DNA replication factor A complex subunit that binds single-stranded DNA and is blocked by anti-cancer drug adozelesin replication factor A; F18A1.5 encodes the C. elegans ortholog of the replication protein A (RPA) large subunit; by homology, the F18A1.5 gene product is predicted to function as a DNA binding and oligonucleotide oligosaccharide binding (OB) protein that is required for DNA replication, repair, and recombination; large-scale RNAi screens indicate that the product of F18A1.5 is essential for embryonic development, and that in yeast two-hybrid assays interacts with the product of M04F3.1, the RPA medium subunit; in situ hybridization studies indicate that F18A1.5 transcripts are expressed in germ cells. F18A1.7 F18A1.7 Protein with weak similarity to C. elegans C10F3.1 gene product F18A1.8 F18A1.8 Protein of unknown function F18A11.1 puf-6;F18A11.1 Protein with pumilio-family RNA binding domains; required for germline development Pumilio-family RNA binding domains (aka PUM-HD, Pumilio homology domain) (6 domains); The puf-6 gene encodes a predicted RNA binding protein that is a member of the conserved PUF (Pumilio and FBF) family of RNA binding proteins; PUF-6 appears to function redundantly with other PUF family members during primordial germ cell development, and interacts with GEX-3, a predicted transmembrane protein that is essential for embryonic tissue morphogenesis. F18A11.2 F18A11.2 Protein containing a CRAL-TRIO domain, has a region of low similarity to a region of rat AJ132352, which is a 45 kD secretory protein from olfactory epithelium that has high affinity GTP binding and low GTPase activity retinal-binding like protein F18A11.3 F18A11.3 Protein of unknown function F18A11.6 F18A11.6 Protein of unknown function, putative paralog of C. elegans B0273.3 gene product that has similarity in its C-terminal region to human small nuclear RNA activating complex polypeptide 3(SNAPC3) F18A12.1 F18A12.1 Member of the M13 peptidase family of zinc metalloproteases, has low similarity to mel transforming oncogene-like protein 1 (mouse Mell1), which is a type II membrane bound metalloprotease with a secreted alternative form (soluble secreted endopeptidase) peptidase; F18A12.1 encodes a neprilysin; neprilysins are thermolysin-like zinc metallopeptidases, found on the outer surface of animal cells, that negatively regulate small signalling peptides (e.g., enkephalin, tachykinin, insulin, and natriuretic peptides) by cleaving them; F18A12.1 has no clear orthologs in other organisms. F18A12.2 F18A12.2 Protein of unknown function F18A12.3 F18A12.3 Member of the M13 peptidase family of zinc metalloproteases, has weak similarity to endothelin-converting enzyme 1 (human ECE1), which is a membrane-bound protease that generates endothelin vasoconstrictors and is associated with developmental defects peptidase; F18A12.3 encodes a neprilysin; neprilysins are thermolysin-like zinc metallopeptidases, found on the outer surface of animal cells, that negatively regulate small signalling peptides (e.g., enkephalin, tachykinin, insulin, and natriuretic peptides) by cleaving them; F18A12.3 has no clear orthologs in other organisms. F18A12.4 F18A12.4 Member of the M13 peptidase family of zinc metalloproteases, has weak similarity to neprilysin (enkephalinase, human MME), which is a membrane-bound neutral endopeptidase that inactivates regulatory peptides, some variants are associated with anxiety peptidase; F18A12.4 encodes a neprilysin; neprilysins are thermolysin-like zinc metallopeptidases, found on the outer surface of animal cells, that negatively regulate small signalling peptides (e.g., enkephalin, tachykinin, insulin, and natriuretic peptides) by cleaving them; F18A12.4 has no clear orthologs in other organisms. F18A12.5 F18A12.5 Member of the M13 peptidase family of zinc metalloproteases, has weak similarity to endothelin-converting enzyme 1 (rat Rn.7000), which is a membrane-bound zinc metalloprotease that generates the endothelin vasoconstrictors peptidase; F18A12.5 encodes a neprilysin; neprilysins are thermolysin-like zinc metallopeptidases, found on the outer surface of animal cells, that negatively regulate small signalling peptides (e.g., enkephalin, tachykinin, insulin, and natriuretic peptides) by cleaving them; F18A12.5 has no clear orthologs in other organisms. F18A12.6 F18A12.6 Member of the M13 peptidase family of zinc metalloproteases, has weak similarity to endothelin-converting enzyme 1 (rat Rn.7000), which is a membrane-bound zinc metalloprotease that generates the endothelin vasoconstrictors peptidase; F18A12.6 encodes a neprilysin; neprilysins are thermolysin-like zinc metallopeptidases, found on the outer surface of animal cells, that negatively regulate small signalling peptides (e.g., enkephalin, tachykinin, insulin, and natriuretic peptides) by cleaving them; F18A12.6 has no clear orthologs in other organisms. F18A12.7 F18A12.7 Protein with strong similarity to C. elegans F08D12.11 gene product F18A12.8 F18A12.8 Member of the M13 peptidase family of zinc metalloproteases, has moderate similarity to endothelin-converting enzyme 1 (rat Rn.7000), which is a membrane-bound zinc metalloprotease that generates the endothelin vasoconstrictors peptidase; F18A12.8 encodes two isoforms of a neprilysin; neprilysins are thermolysin-like zinc metallopeptidases, found on the outer surface of animal cells, that negatively regulate small signalling peptides (e.g., enkephalin, tachykinin, insulin, and natriuretic peptides) by cleaving them; F18A12.8A is closely paralogous to ZK20.6, and orthologous to CG9761 in Drosophila melanogaster; F18A12.8 is homologous, and possibly orthologous, to human ECE1 (OMIM:600423; mutation leads to Hirschsprung disease, cardiac defects, and autonomic dysfunction); more generally, F18A12.8A falls into a group of proteins that includes the classical neprilysins found in mammals (e.g., PEX [OMIM:307800] and the enkephalin cleaving enzymes). F18C12.1 che-3;avr-1;caf-2;osm-2;che-8;F18C12.1 Dynein heavy chain; required for chemotaxis towards water-soluble chemicals and for appropriate sensory cilia structure dynein heavy chain; The dynein heavy chain (DHC) 1b isoform that affects the establishment and maintainance of the structural integrity of sensory cilia and also has a role in intraflagellar transport; it is expressed in ciliated sensory neurons. F18C12.2 rme-8;F18C12.2 Required for receptor-mediated endocytosis and fluid-phase endocytosis DNA-J like domain; The rme-8 gene encodes a J-domain protein that is required for both receptor-mediated and fluid-phase endocytosis in coelomocytes and other cell types, and that is also required for development and viability. F18C12.3 F18C12.3 Protein of unknown function F18C5.1 F18C5.1 Protein of unknown function, has low similarity to uncharacterized C. elegans Y40H7A.6 7TM chemoreceptor, sra family F18C5.2 F18C5.2 Putative ortholog of H. sapiens WRN gene product, the gene for which is mutated in people with Werner's syndrome, member of the RECQ family of helicases wrn-1 encodes an ortholog of human WRN, which when mutated leads to Werner syndrome (OMIM:277700), and one of four C. elegans homologs of the RecQ DNA helicase family that includes E. coli RecQ; by homology, WRN-1 is predicted to function as a helicase, DNA-dependent ATPase, and exonuclease that plays a key role in DNA replication, recombination, and repair; in C. elegans, loss of wrn-1 activity, via mutation or large-scale RNA-mediated interference (RNAi) screens, does not result in any obvious abnormalities, as animals are viable and fertile, have normal lifespans, and do not appear to have a high rate of genomic instability. F18C5.3 F18C5.3 Protein of unknown function F18C5.4 F18C5.4 Putative ortholog of C. elegans Y51B9A.3 gene product F18C5.5 F18C5.5 Protein of unknown function F18C5.6 F18C5.6 Member of C. elegans Sra integral membrane protein family, which contain 6-7 hydrophobic, putative transmembrane, regions, has high similarity to uncharacterized C. elegans F18C5.8 7TM chemoreceptor, sra family F18C5.7 F18C5.7 TcA transposase transposase F18C5.8 F18C5.8 Protein of unknown function, has weak similarity to uncharacterized serpentine receptor class A 1 (C. elegans SRA-1) 7TM chemoreceptor, sra family F18C5.9 F18C5.9 Protein with strong similarity to C. elegans F26G1.5 gene product F18E2.1 F18E2.1 Member of the purple acid phosphatase family, which catalyze hydrolysis of phosphate esters, contains an N-terminal Ig-like domain, has moderate similarity to uncharacterized C. elegans F21A3.2 acid phophatase like F18E2.2 F18E2.2 Member of the ABC transporter family, which are involved in translocation of a variety of compounds across biological membranes, has moderate similarity to S. cerevisiae Kre30p, which is involved in cell growth and maintenance ABC transpoter F18E2.3 F18E2.3 Protein with moderate similarity to stromal antigen 1 (human STAG1), which is a component of a 14S cohesin complex that binds to chromatin before and after mitosis and may play a role in organizing interphase chromatin scc-3 encodes a cohesin complex subunit homologous to Saccharomyces cerevisiae Irr1p/Scc3p; SCC-3 is required during meiosis for synaptonemal complex formation and sister chromatid cohesion, proper localization of REC-8 to chromosomes, mitotic chromosome segregation, embryonic development, and vulval morphogenesis; in embryos, SCC-3 forms a cohesin complex with SCC-1, SMC-1, SMC-3, and TIM-1, a HEAT/Armadillo repeat-containing protein related to Drosophila TIMELESS; in the germline, SCC-3 associates with chromatin of transistion zone nuclei, assembles along the longitudinal axes of synapsed chromosomes at pachytene, and unlike other cohesins, localizes throughout chromatin at diakinesis; SCC-3 localization requires TIM-1, and SCC-3 and REC-8 are mutually required for chromatin localization. F18E2.4 F18E2.4 Protein containing a DUF32 domain of unknown function, has high similarity to uncharacterized C. elegans M199.1 F18E2.5 gpa-13;F18E2.5 Member of the G protein alpha subunit family guanine nucleotide-binding protein; gpa-13 encodes a member of the G protein alpha subunit family of heterotrimeric GTPases; it is expressed in ADF, ASH, AWC, PHA, and PHB. F18E3.1 F18E3.1 Protein of unknown function, has high similarity to uncharacterized C. elegans F56D5.10 7TM chemoreceptor, srxa family F18E3.10 F18E3.10 Member of the 7-transmembrane chemoreceptor family of G protein-coupled receptors (GPCR), has weak similarity to uncharacterized C. elegans Y47G7B.1 F18E3.2 F18E3.2 Protein of unknown function, has low similarity to uncharacterized C. elegans H27D07.4 7TM chemoreceptor, srw family F18E3.3 F18E3.3 Member of the 7-transmembrane chemoreceptor family of G protein-coupled receptors (GPCR), has weak similarity to uncharacterized C. elegans Y8A9A.1 F18E3.4 F18E3.4 Putative paralog of C. elegans F18E3.5 7TM chemoreceptor, srw family F18E3.5 F18E3.5 Putative paralog of C. elegans Y57G7A.4 7TM chemoreceptor, srw family F18E3.6 F18E3.6 Protein of unknown function, has strong similarity to C. elegans W06G6.8 7TM chemoreceptor, srw family F18E3.7 F18E3.7 Putative ortholog of C. elegans C47A10.5 gene product D-amino acid oxidase F18E3.8 F18E3.8 Protein with strong similarity to C. elegans F18E3.5 gene product F18E3.9 F18E3.9 Protein of unknown function, has moderate similarity to uncharacterized C. elegans F20E11.6, which is a predicted G protein-coupled receptor F18E9.1 F18E9.1 Protein of unknown function F18E9.2 nlp-7;F18E9.2 MSFamide neurotransmitter F18E9.3 F18E9.3 Protein of unknown function F18E9.4 F18E9.4 Protein of unknown function F18E9.5 F18E9.5 Protein containing two Jumonji (jmjC) domains, has low similarity to uncharacterized C. elegans F23D12.5 F18E9.6 F18E9.6 Protein containing two GLTT repeat region domains F18E9.7 F18E9.7 Protein of unknown function, has low similarity to uncharacterized C. elegans C33G3.5 F18F11.1 F18F11.1 Protein of unknown function, has high similarity to uncharacterized peroxisomal membrane protein 4 (human PXMP4) F18F11.2 F18F11.2 Protein with moderate similarity to C. elegans cdh-8 gene product F18F11.4 F18F11.4 Protein containing two protein kinase domains, has a region of low similarity to a region of mitogen activated protein kinase kinase kinase 3 (human MAP3K3), which activates the SAPK (MAPK8) and ERK (MAPK3) but not the p38 MAP kinase (MAPK14) pathway serine/threonine-protein kinase F18G5.1 F18G5.1 Protein of unknown function F18G5.2 F18G5.2 Protein of unknown function pes-8 encodes a novel protein that contains a proline-rich region and a predicted transmembrane domain, but no otherwise recognizably conserved domains; pes-8 was identified in promoter trapping screens and based on large-scale RNA-mediated interference (RNAi) screens, appears to be required for egg laying, germline development, locomotion, and regulation of adult lifespan; a pes-8 reporter is expressed at the cell surfaces of the spermathecal valve cell, the uterine wall, the vulva, and the rectal epithelium; strong expression is also detected in the uterus during its development; PES-8 may be required for normal morphology of the openings of the spermathecal valve, the vulva, and the rectum, a hypothesis consistent with its expression pattern and RNAi phenotype. F18G5.3 gpa-12;F18G5.3 Member of the G protein alpha subunit family guanine nucleotide-binding protein; gpa-12 encodes a member of the G protein alpha subunit family of heterotrimeric GTPases; it is expressed in the pharynx and in the hypodermis. F18G5.4 F18G5.4 Protein containing neurotransmitter-gated ion-channel ligand binding and transmembrane domains, has a region of moderate similarity to acetylcholine receptor alpha 10 subunit (rat Chrna10), which may function in cholinergic signaling member of the ligand-gated ionic channels family F18G5.5 F18G5.5 Protein of unknown function F18G5.6 F18G5.6 Protein of unknown function F18H3.1 F18H3.1 Protein containing a SPRY (SPla and RYanodine Receptor) domain, has high similarity to uncharacterized human LOC57213 F18H3.3 F18H3.3 Protein with high similarity to poly(A)-binding protein cytoplasmic 4 (human PABPC4), which may function in translation and mRNA stability, contains eight RNA recognition motifs (RRM, RBD, or RNP) and a polyadenylate binding protein (PABP) unique domain poly-adenylate binding protein; pab-2 encodes a polyadenylate-binding protein 1 homolog with high similarity to human PABP 1. F18H3.4 F18H3.4 Putative coiled-coil protein, has weak similarity to myosins F18H3.5 F18H3.5 Putative ortholog of C. elegans cdk-4 gene product serine/threonine kinase (CDC2/CDKX subfamily); cdk-4 encodes two isoforms of a cyclin-dependent serine/threonine protein kinase orthologous to human CDK4 and CDK6 (OMIM:123829 and OMIM:603368, mutated in cutanous malignant melanoma) which complex with D-type cyclins to regulate progression through the G1 phase of the cell cycle; CDK-4 activity is essential for G1 progression in postembryonic blast cells and as a result, cdk-4 mutant animals generally arrest during larval stages; the lethality generated by cdk mutations, also seen in animals doubly mutant for cdk-4 and cyd-1, a C. elegans D-type cyclin, can be suppressed by mutations in lin-35/Rb suggesting that, as in other organisms, LIN-35/Rb may be a major target of CDK-4/CYD-1 kinase activity; CDK-4 expression is first detected in neuronal and hypodermal lineages during mid-to-late embryogenesis, with postembryonic expression detected in hypodermal seam cells, cells of the P lineage which will give rise to ventral cord neurons, and cells of the somatic gonad, the vulva, and the intestine. F19B10.1 F19B10.1 Protein of unknown function F19B10.10 F19B10.10 Putative paralog of C. elegans K12B6.8 gene product F19B10.11 F19B10.11 Protein of unknown function, has weak similarity to C. elegans F19B10.5 F19B10.2 F19B10.2 Protein with moderate similarity to C. elegans K12B6.8 gene product F19B10.3 F19B10.3 Protein of unknown function F19B10.4 F19B10.4 Putative coiled-coil protein, has weak similarity to myosins F19B10.5 F19B10.5 Protein of unknown function, has weak similarity to C. elegans F19B10.11 F19B10.6 F19B10.6 Protein of unknown function F19B10.7 F19B10.7 Member of the G protein-coupled receptor protein family 7TM chemoreceptor, srx family F19B10.8 F19B10.8 Protein of unknown function, has high similarity to uncharacterized C. elegans F19B10.7 7TM chemoreceptor, srx family F19B10.9 F19B10.9 Protein containing a T-box domain, which bind DNA, has weak similarity to a region of T-box 22 (human TBX22), which plays a role in palatogenesis and is associated with X-linked cleft palate F19B2.2 F19B2.2 Protein with strong similarity to C. elegans F19B2.4 gene product F19B2.4 F19B2.4 Putative ortholog of C. elegans Y116F11B.4 gene product F19B2.5 F19B2.C;F19B2.5 Putative ortholog of C. elegans F19B2.G gene product F19B2.8 F19B2.8 Protein of unknown function, has moderate similarity to C. elegans C32H11.2 F19B2.A F19B2.1;F19B2.A Protein containing a DUF216 domain of unknown function F19B2.D F19B2.6;F19B2.D Protein with moderate similarity to C. elegans Y116F11.A gene product F19B2.E F19B2.7;F19B2.E Protein with strong similarity to C. elegans Y113G7A.12 gene product F19B2.F F19B2.3;F19B2.F Protein of unknown function, has high similarity to uncharacterized C. elegans Y116F11B.5 F19B6.1 F19B6.1 Member of the phosphoribulokinase and uridine kinase family, which catalyze conversion of ribulose-5-phosphate to ribulose-1,5-phosphate, has moderate similarity to uridine kinase (S. cerevisiae Urk1p), which converts ATP and uridine to ADP and UMP uridine kinase F19B6.2 F19B6.2 Protein with moderate similarity to ubiquitin fusion degradation protein (S. cerevisiae Ufd1p), which is involved in degradation of ubiquitin fusion proteins F19B6.3 F19B6.3 Protein with moderate similarity to C. elegans H01G02.1 gene product F19B6.4 F19B6.4 Member of the ABC transporter family, has low similarity to white protein (Drosophila) (ATP-binding cassette subfamily G member 1) (mouse Abcg1), which is an ABC transporter involved in cellular sterol homeostasis white protein like F19C6.1 F19C6.1 Protein with high similarity to G protein-coupled receptor kinase 6 (human GPRK6), which is a protein kinase that regulates desensitization of G protein-coupled receptors, contains a protein kinase domain and a regulator of G protein signaling domain G protein-coupled receptor kinase F19C6.2 F19C6.2 Protein of unknown function F19C6.3 F19C6.3 Protein containing an epidermal growth factor (EGF)-like domain, has a region of low similarity to a region of nel-like 1 (rat Nell1), which is a heparin binding protein that is a target of protein kinase C beta1 (rat Prkcb1) EGF-like domain F19C6.4 F19C6.4 Member of the M13 peptidase family of zinc metalloproteases, has high similarity to uncharacterized C. elegans C17B7.10 F19C6.4 encodes a neprilysin; neprilysins are thermolysin-like zinc metallopeptidases, found on the outer surface of animal cells, that negatively regulate small signalling peptides (e.g., enkephalin, tachykinin, insulin, and natriuretic peptides) by cleaving them; F19C6.4 has no clear orthologs in other organisms. F19C6.5 F19C6.5 Protein of unknown function F19C7.1 F19C7.1 Protein of unknown function, has low similarity to uncharacterized C. elegans LLC1.2 F19C7.2 F19C7.2 Member of the carboxypeptidase protein family lysosomal carboxypeptidase F19C7.3 F19C7.3 Protein of uknown function, has high similarity to uncharacterized C. elegans F21D9.1 F19C7.4 F19C7.4 Protein with low similarity to dipeptidyl peptidase II (quiescent cell proline dipeptidase, rat Dpp7), which is a serine protease that may be involved in response to wounding lysosomal carboxypeptidase F19C7.5 F19C7.5 Protein of unknown function, has weak similarity to C. elegans F21D9.2 F19C7.6 F19C7.6 Protein of unknown function F19C7.7 F19C7.7 Protein containing two collagen two triple helix repeats and one nematode cuticle collagen N-terminal domain, has moderate similarity to C. elegans SQT-3, which is a putative collagen that plays a role in morphogenesis of the epithelium cuticular collagen F19C7.8 F19C7.8 Protein containing two Src homology 3 (SH3) domains, which bind proline-rich peptides F19D8.1 twk-6;F19D8.1 Member of the ion transport family, has a region of low similarity to a region of potassium channel subfamily K member 2 (mouse Kcnk2), which is activated by membrane stretch, arachidonate, and intracellular acidification potassium channel protein; twk-23 encodes one of 44 C. elegans TWK (two-P domain K+) potassium channel subunits that contain two pore-forming domains and four transmembrane domains; the precise role of TWK-23 in C. elegans development and/or behavior is not yet known, however TWK-23 may function redundantly with other TWK channels; TWK-23 is expressed in neurons, muscle, the posterior intestine, and diffusely in many other tissues. F19D8.2 F19D8.2 Protein of unknown function F19F10.1 F19F10.1 Protein containing an ETS domain, which bind promoter DNA, has a region of moderate similarity to a region of avian erythroblastosis virus E-26 (v-ets) oncogene related (mouse Erg), which regulates Ig heavy-chain gene expression DNA-binding protein F19F10.10 F19F10.10 Protein of unknown function, has a region of low similarity to a region of C. elegans LIN-15B, which is a negative regulator of the LET-23 receptor-tyrosine kinase, LET-60 ras signaling pathway F19F10.11 F19F10.11 Protein of unknown function, putative paralog of C. elegans F19F10.11A F19F10.12 F19F10.12 Protein with moderate similarity to C. elegans Y67H2A.1 gene product F19F10.3 F19F10.3 Member of an uncharacterized protein family F19F10.4 F19F10.4 Member of the transthyretin-like family F19F10.5 F19F10.5 Protein containing an ETS domain, which bind promoter DNA, has a region of low similarity to a region of C. elegans LIN-1, which is a putative transcription factor involved in cell fate decisions in vulval development DNA-binding protein F19F10.6 F19F10.6 Member of the C-type lectin family F19F10.7 F19F10.7 Protein of unknown function F19F10.8 F19F10.8 Protein of unknown function F19F10.9 F19F10.9 Protein with low similarity to hypoxia-associated factor (mouse Sart1), which is a transcriptional activator that binds to the erythropoietin promoter and modulates hypoxia-induced EPO and VEGF gene expression and may invoke a hypersensitive response The F19F10.9 gene encodes a homolog of the human SART1 gene, which encodes a protein recognised by IgE that may be involved in atopic disease. F19G12.1 F19G12.1 Putative paralog of C. elegans T13A10.2 gene product F19G12.2 F19G12.2 Member of the ribonucleotide reductase small chain family, has a region of high similarity to a region of p53-inducible ribonucleotide reductase small subunit 2 homolog (human RRM2B), which converts ribonucleotides to deoxyribonucleotides This gene encodes a protein predicted by Eisenberg and coworkers, with 52% accuracy, to be mitochondrial. F19G12.3 F19G12.3 Protein containing a PAZ (Piwi, Argonaut and Zwille) domain, which may mediate protein-protein interactions F19G12.4 F19G12.4 Protein of unknown function F19G12.5 F19G12.5 Protein of unknown function, has high similarity to uncharacterized C. elegans C02E7.2 7TM chemoreceptor, srh family F19G12.7 F19G12.7 Protein of unknown function, has high similarity to uncharacterized C. elegans AC3.3 abu-2 encodes a transmembrane protein with a predicted signal sequence, a glutamine/asparagine-rich domain and multiple cysteine-rich repeats (DUF139); abu-2 expression is induced by blockage of the unfolded-protein response in the endoplasmic reticulum, and ABU-2 may help protect the organism from damage by improperly folded nascent protein. F19H6.1 F19H6.1 Protein with high similarity to never in mitosis gene A (NIMA)-related expressed kinase 7 (mouse Nek7), which phosphorylates p70 ribosomal S6 kinase, contains a protein kinase domain serine/threonine kinase F19H6.2 F19H6.2 Member of the globin family of oxygen transporters, has weak similarity to uncharacterized C. elegans F52A8.4 globin like F19H6.3 F19H6.3 Putative paralog of C. elegans F11E6.7 gene product F19H6.4 F19H6.4 Member of the 3-oxo-5-alpha-steroid 4-dehydrogenase family, which are involved in dihydrotestosterone biosynthesis, has moderate similarity to rat Srd5a1, which is a steroid 5 alpha-reductase that converts testosterone to dihydrotestosterone 3-oxo-5-alpha-steroid 4-dehydrogenase F19H6.5 F19H6.5 Protein of unknown function F19H6.6 F19H6.6 Protein of unknown function F19H8.1 F19H8.1 Member of the glycosyltransferase 20 family, has a region of low similarity to trehalose-6-phosphate synthase (S. cerevisiae Tps1p), which is a component of trehalose-6-phosphate synthase-phosphatase complex trehalose phosphate synthase; tps-2 encodes one of two trehalose-6-phosphate synthase proteins in C. elegans, and RNAi of both enzymes leads to a more than 90% reduction decrease in trehalose levels, but does not appear to affect viability or development; the tps-2 mRNA is expressed throughout development. F19H8.2 F19H8.2 Protein of unknown function F19H8.3 F19H8.3 Protein with high similarity to ADP-ribosylation factor like 3 (human ARL3), which may be involved in intracellular protein trafficking, member of the ADP-ribosylation factor (ARF) family, which are GTP-binding proteins involved in protein trafficking ADP-ribosylation factors (Arf family) (contains ATP/GTP binding P-loop); arl-3 encodes a member of the ARL (ADP-ribosylation factor(ARF)-like) family of proteins which are very similar to ARF proteins but lack the ability to stimulate ADP ribosylation by cholera toxin; as loss of arl-3 activity via RNA-mediated interference (RNAi) does not result in any abnormalities, the precise role of ARL-3 is not yet known. F19H8.4 F19H8.4 Protein of unknown function, has low similarity to uncharacterized C. elegans C53B4.8 F20A1.1 F20A1.1 Protein of unknown function, has high similarity to uncharacterized C. elegans F57E7.1 F20A1.10 F20A1.10 Protein of unknown function, has high similarity to uncharacterized C. elegans C33G8.4 F20A1.2 F20A1.2 G protein-coupled receptor of unknown function, no homolog found in human or D. melanogaster F20A1.3 F20A1.3 Member of the G protein-coupled receptor protein family 7TM chemoreceptor, srsx family F20A1.4 F20A1.4 Protein of unknown function F20A1.5 F20A1.5 Protein of unknown function F20A1.6 F20A1.6 Protein of unknown function F20A1.7 F20A1.7 Member of the 4 TM potassium channel protein family twk-11 encodes one of more than 40 TWK (two-P domain K+) potassium channels in C. elegans that contain two pore regions and four transmembrane domains; orthologous to C. briggsae CBG19123 with some similarity to Drosophila CG6004. F20A1.8 F20A1.8 Protein of unknown function F20A1.9 F20A1.9 Protein containing a SPRY (SPla and RYanodine Receptor) domain, has a region of high similarity to a region of DEAD box protein 1 (human DDX1), which is an ATP-dependent RNA helicase that has a role in the processing of pre-mRNAs F20B10.1 F20B10.1 Protein containing two epidermal growth factor (EGF)-like domains and an extracellular laminin G domain, has a region of low similarity to a region of neurexin 4 (human CNTNAP1), which is a neuronal paranodal transmembrane receptor neurexin III like F20B10.2 F20B10.2 Protein containing an extracellular laminin G domain neurexin I like F20B10.3 F20B10.3 Protein of unknown function F20B4.2 F20B4.2 Protein of unknown function, putative paralog of C. elegans T16G12.3 F20B4.3 F20B4.3 Protein of unknown function, putative paralog of C. elegans T05A1.4 F20B4.4 F20B4.4 Protein of unknown function, putative paralog of C. elegans T05A1.4 F20B4.5 F20B4.5 Protein of unknown function, has strong similarity to C. elegans H11L12.1 F20B4.6 F20B4.6 Putative paralog of C. elegans F59G1.1 F20B4.7 F20B4.7 Putative paralog of C. elegans F09C3.6 F20B6.1 F20B6.1 Member of the protein-tyrosine phosphatase family, which are involved in control of cell growth, proliferation, and differentiation, has a region of low similarity to a region of mouse Ptpn20, which is a non-receptor type protein tyrosine phosphatase protein tyrosine phosphatase F20B6.2 F20B6.2 Protein with strong similarity to human ATP6B1, which is associated with renal tubular acidosis with sensorineural deafness, contains ATP synthase alpha or beta family nucleotide-binding, beta-barrel, and subunit alpha and beta C-terminal domains vacuolar ATP synthase (strong) F20B6.3 F20B6.3 Member of the ABC transporter family, which are involved in translocation of a variety of compounds across biological membranes, contains two ABC transporter transmembrane domains, has low similarity to multidrug resistance protein 4 (human ABCC4) ABC transporter F20B6.4 F20B6.4 Protein of unknown function F20B6.5 F20B6.5 Protein with weak similarity to C. elegans let-858 (Nucampholin, associates with chromatin in adult germline cells) F20B6.6 F20B6.6 Protein of unknown function, has weak similarity to C. elegans ZK354.8 F20B6.7 F20B6.7 Protein of unknown function F20B6.8 F20B6.8 Protein containing two protein kinase domains, has high similarity to a region of homeodomain interacting protein kinase 2 (mouse Hipk2), which is a protein kinase that binds to and represses the transcriptional activity of homeodomain proteins serine/threonine protein kinase; hpk-1 encodes a predicted dual-specificity protein kinase with distant homology to the vertebrate protein kinase DYRK1A and the Drosophila homolog mini-brain; increased expression of DYRK1A is implicated in the neuropathology of trisomy 21/Down syndrome; RNA interference of hpk-1 does not result in any detectable phenotype; the HPK-1::GFP fusion protein is localized to the nucleus and is expressed in cleavage stage embryos. F20B6.9 F20B6.9 Protein with weak similarity to C. elegans Y13C8_223.A gene product F20C5.1 F20C5.1 Protein of unknown function, has a region of moderate similarity to a region of poly (ADP-ribose) glycohydrolase (mouse Parg), which functions in polymeric ADP-ribose turnover, may act in DNA repair, and inhibition blocks oxidative death of astrocytes poly(ADP)ribose glycohydrolases F20C5.2 klp-11;krp95;F20C5.2 Putative kinesin-like protein, has strong similarity to H. sapiens KIF3B, kinesin family member 3B kinesin; klp-11 encodes a predicted kinesin protein with high similarity to OSM-3 in the motor domain and encodes one of the motor subunits of heterotrimeric CeKinesin-II; expressed throughout the nervous system. F20C5.3 F20C5.3 Protein of unknown function F20C5.4 F20C5.4 Protein with low similarity to S. cerevisiae Cdc50p, which is a protein that leads to a cell-division-cycle (CDC) phenotype when mutated Yeast YCY4 like protein F20C5.5 F20C5.5 Putative coiled-coil protein, has weak similarity to human Golgi autoantigens and centromere proteins F20C5.6 F20C5.6 Putative coiled-coil protein, has similarity to human MYH9 protein, a myosin heavy polypeptide spectrin F20D1.1 F20D1.1 Protein of unknown function F20D1.10 F20D1.10 Protein with weak similarity to D. melanogaster CG17680 (CG17680 gene product) F20D1.2 F20D1.2 Protein containing a TBC domain, which may be found in GTPase activators of Rab-like small GTPases, has low similarity to uncharacterized human FLJ11046 F20D1.3 F20D1.3 Protein of unknown function F20D1.4 F20D1.4 Protein of unknown function, has a region of moderate similarity to a region of purine rich element binding protein A (mouse Pura), which is a single-stranded DNA-RNA binding protein implicated in the control of transcription and DNA replication transcriptional activator protein PUR-alpha like F20D1.5 arl-7;F20D1.5 Member of the ADP-ribosylation factor (ARF) family, which are GTP-binding proteins involved in protein trafficking, has moderate similarity to S. cerevisiae Arf1p, which is a GTP-binding protein involved in assembly of coated vesicles for secretion F20D1.6 F20D1.6 Protein with weak similarity to RAB3 GTPase-activating protein (human RAB3GAP), which is a GTPase-activating protein that may be involved in calcium-dependent exocytosis of synaptic vesicles Human mRNA KIAA0066 predicted protein like F20D1.7 F20D1.7 Protein containing seven leucine rich repeats, which mediate protein-protein interactions, has a region of low similarity to a region of leucine-rich repeat-containing G protein-coupled receptor 7 (human LGR7), which binds relaxin Leucine Rich Repeat (2 copies) (4 domains) F20D1.8 F20D1.8 Protein of unknown function, has moderate similarity to a region of C. elegans CUT-1, which is a cuticulin component cuticlin F20D1.9 F20D1.9 Member of the mitochondrial carrier protein family of membrane transporters, has moderate similarity to a region of solute carrier family 25 member 13 (citrin, human SLC25A13), which is associated with adult onset type II citrullinemia Mitochondrial carrier proteins F20D12.1 F20D12.1 Protein containing a piwi domain and a PAZ (Piwi, Argonaut and Zwille) domain, which may mediate protein-protein interactions, has a region of weak similarity to a region of C. elegans ALG-2, which is a piwi-related protein involved in stRNA production F20D12.2 F20D12.2 Protein of unknown function, has low similarity to a region of minichromosome maintenance deficient 3 associated protein (mouse Mcm3ap), which is a DNA primase that binds mouse Mcmd and may regulate the development of antigen-driven B-cells F20D12.3 F20D12.3 Protein of unknown function, has low similarity to uncharacterized Bardet-Biedl syndrome 2 (human BBS2), which is associated with the autosomal recessive disorder Bardet Biedl syndrome upon gene mutation bbs-2 is orthologous to human BBS2 (OMIM:606151, mutated in Bardet-Biedl syndrome 2); while the function of BBS-2 is unknown, it shares conserved domains with its human paralogs BBS1 and BBS7, which also are mutated in other Bardet-Biedl syndromes. F20D12.4 czw-1;F20D12.4 Protein involved in chromosome segregation, has similarity to human and D. melanogaster ZW10 centromere/kinetochore proteins F20D12.5 F20D12.5 Protein with high similarity to cysteine-rich intestinal protein (human CRIP1), which is a zinc binding protein and putative zinc carrier protein that may have a role in cell proliferation or cell differentiation, contains two LIM domains F20D12.6 ceh-19;pceh16-1;F20D12.6 Homeodomain transcription factor, has similarity over the homeodomain to many human and D. melanogaster homeodomain transcription factors homeobox protein; ceh-19 encodes a homeobox protein similar to Bar-like homeoproteins from Drosophila and vertebrates; it has no known function or expression pattern. F20D12.7 F20D12.7 Protein of unknown function F20D6.1 F20D6.1 Protein containing a PDZ, DHR, or GLGF domain, which are found in signaling proteins F20D6.10 F20D6.10 Protein of unknown function F20D6.11 F20D6.11 Member of the pyridine nucleotide-disulphide oxidoreductase family, which are flavoproteins, contains one Rieske iron-sulfur protein 2Fe-2S domain, has a region of weak similarity to a region of programmed cell death 8 (human PDCD8) oxidoreductase; This gene encodes a protein predicted by Eisenberg and coworkers, with 52% accuracy, to be mitochondrial. F20D6.2 F20D6.2 Member of the domain of unknown function DUF13 family, has moderate similarity to uncharacterized C. elegans R09H10.2 F20D6.3 F20D6.3 Member of the serpin family of serine protease inhibitors, has low similarity to squamous cell carcinoma antigen 2 (human SERPINB4), which inhibits chymotrypsin-like serine proteases and serves as a predictive marker for squamous cell carcinomas serine protease inhibitor F20D6.4 F20D6.4 Member of the serpin family of serine protease inhibitors, has low similarity to antithrombin III (human SERPINC1), which mediates heparin binding-dependent inhibition of thrombin (F2) and other coagulation factors and inhibits angiogenesis serine protease inhibitor F20D6.5 F20D6.5 Protein of unknown function, has moderate similarity to C. elegans F58B4.5 F20D6.6 F20D6.6 Member of the serine or threonine protein phosphatase family, has low similarity to S. cerevisiae Glc7p, which is a protein serine or threonine phosphatase required for glucose repression and many other processes serine/threoninie protein phophatase F20D6.8 F20D6.8 Protein of unknown function, has a region of low similarity to a region of human GEM, which binds GTP, calmodulin, microtubules, and the kinesin-like protein KIF9 and may be involved in cell shape control RAS-like protein F20D6.9 F20D6.9 Protein with high similarity to histone H3.1 (S. pombe Hht1p), which is involved in centromere-kinetochore complex maturation, member of the histone family of nucleosomal core proteins histone H3 F20E11.1 F20E11.1 Member of an uncharacterized protein family F20E11.10 F20E11.10 Member of the 7-transmembrane chemoreceptor family of G protein-coupled receptors (GPCR), has strong similarity to uncharacterized C. elegans Y68A4A.1 F20E11.11 F20E11.11 Member of the 7-transmembrane chemoreceptor family of G protein-coupled receptors (GPCR), has high similarity to uncharacterized C. elegans F40D4.1 F20E11.12 F20E11.12 Member of the 7-transmembrane chemoreceptor family of G protein-coupled receptors (GPCR), has strong similarity to uncharacterized C. elegans F40D4.2 F20E11.13 F20E11.13 Member of the 7-transmembrane chemoreceptor family of G protein-coupled receptors (GPCR) F20E11.2 F20E11.2 Protein of uknown function, has high similarity to uncharacterized C. elegans F40D4.5, which is predicted to be a G protein-coupled receptor F20E11.3 F20E11.3 Member of the 7-transmembrane chemoreceptor family of G protein-coupled receptors (GPCR), has high similarity to uncharacterized C. elegans F40D4.3 F20E11.4 F20E11.4 Member of the 7-transmembrane chemoreceptor family of G protein-coupled receptors (GPCR), has strong similarity to uncharacterized C. elegans Y68A4A.3 F20E11.5 F20E11.5 Member of an uncharacterized protein family F20E11.6 F20E11.6 Protein of unkown function, has high similarity to uncharacterized C. elegans W06G6.8, which is predicted to be a G protein-coupled receptor 7TM chemoreceptor, srw family F20E11.7 F20E11.7 Protein of unknown function, has high similarity to uncharacterized C. elegans Y68A4A.10 F20E11.8 F20E11.8 Member of the 7-transmembrane chemoreceptor family of G protein-coupled receptors (GPCR), has high similarity to uncharacterized C. elegans F40D4.3 F20E11.9 F20E11.9 Member of the 7-transmembrane chemoreceptor family of G protein-coupled receptors (GPCR), has high similarity to uncharacterized C. elegans F20E11.3 F20G2.1 F20G2.1 Member of the short-chain dehydrogenase-reductase family, which are NAD- or NADP-dependent oxidoreductases, has low similarity to mouse Cbr1, which is a broad-specificity NADPH-dependent oxidoreductase that reduces carbonyl compounds dehydrogenase F20G2.2 F20G2.2 Member of the short-chain dehydrogenase-reductase family, which are NAD- or NADP-dependent oxidoreductases, has low similarity to rat Cbr, which is a broad-specificity NADPH-dependent oxidoreductase dehydrogenase; This gene encodes a protein predicted by Eisenberg and coworkers, with 52% accuracy, to be mitochondrial. F20G2.3 F20G2.3 Protein with weak similarity to SEC14-like 2 (tocopherol-associated protein, human SEC14L2), which is an alpha-tocopherol-binding protein that translocates from the cytosol to the nucleus and activates transcription in an alpha-tocopherol-dependent manner F20G2.4 F20G2.4 Member of the astacin (M12A) family of metalloproteases, has high similarity to uncharacterized C. elegans K03B8.5 zinc metalloprotease F20G2.5 F20G2.5 Member of an uncharacterized protein family F20G4.1 F20G4.1 Protein of unknown function F20G4.2 F20G4.2 Protein of unknown function F20G4.3 nmy-2;F20G4.3 Nonmuscle myosin II heavy chain-related protein required for cytokinesis and establishment of early embryonic polarity myosin heavy chain; nmy-2 encodes a maternally expressed nonmuscle myosin II required for polarized cytoplasmic flow, polarized distribution of the PAR proteins, cytokinesis, and for proper anterior-posterior polarity in early embryos; NMY-2 functions with PAR-5 in the onset of the establishment phase of polarization in the C. elegans zygote along the anterior-posterior axis, and nmy-2 is partially redundant with nmy-1 with respect to embryonic elongation; localization of NMY-2 is dynamic in oocytes and embryos. F20H11.1 F20H11.1 Protein containing two phorbol esters or diacylglycerol binding domains (C1 domain), which bind two zinc ions, has moderate similarity to uncharacterized mouse AI449518 F20H11.2 F20H11.2 Protein containing a helicase conserved C-terminal domain, has moderate similarity to uncharacterized human KIAA0963 F20H11.3 F20H11.3 Member of the malate dehydrogenase protein family malate dehydrogenase; mdh-1 encodes a homolog of malate dehydrogenase that is predicted to be mitochondrial. F20H11.4 F20H11.4 Member of the protein-tyrosine phosphatase family, which are involved in control of cell growth, proliferation, differentiation and transformation, has low similarity to C. elegans F10G8.1, which has a role in embryogenesis or morphogenesis protein-tyrosine phosphatase F20H11.5 F20H11.5 Member of the FAD dependent oxidoreductase family, has low similarity to D-amino-acid oxidase (rat Dao), which is a peroxisomal enzyme that catalyzes the oxidation of neutral and basic D-amino acids into the corresponding keto acids D-amino acid oxidase F20H11.6 F20H11.6 Protein of unknown function F21A10.1 F21A10.1 Protein containing an EF hand domain, which are found in signaling, buffering or transport proteins, has low similarity to kv channel-interacting protein 1 (human KCNIP1), which modulates Kv4 subthreshold A-current and neuronal excitability EF hand (2 domains) F21A10.2 F21A10.2 Protein of unknown function, putative paralog of C. elegans F59B10.1 F21A10.3 F21A10.3 Protein of unknown function F21A10.4 F21A10.4 Protein of unknown function F21A3.1 F21A3.1 Member of the 7-transmembrane chemoreceptor family of G protein-coupled receptors (GPCR), has moderate similarity to uncharacterized C. elegans Y59A8A.4 F21A3.2 F21A3.2 Protein containing a purple acid phosphatase N-terminal immunoglobulin-like domain and member of the purple acid phosphatase family, which catalyze hydrolysis of phosphate esters, has moderate similarity to uncharacterized C. elegans F18E2.1 acid phosphatase F21A3.3 F21A3.3 Protein with moderate similarity to C. elegans ZC13.4 EGF-domain protein F21A3.4 F21A3.4 Protein of unknown function, has weak similarity to human myosin phosphatase target subunit 1 dystrophin like protein F21A3.5 F21A3.5 Protein with weak similarity to H. sapiens CSNK1A1 (casein kinase 1, alpha 1) F21A3.6 F21A3.6 Member of the globin family of oxygen transporters globin like F21A3.7 F21A3.7 Protein with strong similarity to des-2, acetylcholine-gated channel subunit F21A9.1 F21A9.1 Protein of unknown function F21A9.2 F21A9.2 Putative C2H2-type zinc finger protein, has weak similarity in the C-terminus to C2H2-type zinc finger proteins zinc finger protein F21C10.1 F21C10.1 Protein containing a CX module domain F21C10.10 F21C10.10 Protein of unknown function F21C10.11 F21C10.11 Protein of unknown function F21C10.3 F21C10.3 Protein containing a CX module domain, has moderate similarity to uncharacterized C. elegans F21C10.4 F21C10.4 F21C10.4 Protein containing a CX module domain, has high similarity to uncharacterized C. elegans B0222.1 F21C10.5 F21C10.5 Protein of unknown function, has weak similarity to C. elegans F21C10.4 F21C10.6 F21C10.6 Protein containing a CX module domain F21C10.7 F21C10.7 Protein containing an immunoglobulin (Ig) domain, which may be involved in protein-protein and protein-ligand interactions, has a region of weak similarity to a region of C. elegans HIM-4, which is involved in recombination and uterine cell adhesion F21C10.8 F21C10.8 Protein of unknown function The protein product of this gene is predicted to contain a glutamine/asparagine (Q/N)-rich ('prion') domain, by the algorithm of Michelitsch and Weissman (as of the WS77 release of WormBase, i.e., in wormpep77). F21C10.9 F21C10.9 Member of the rhodopsin family of G protein-coupled receptors (GPCR), has a region of weak similarity to G protein-coupled receptor 66 (human GPR66), which binds neuromedin U (NMU) to mobilize intracellular calcium F21C3.1 twk-7;F21C3.1 Member of the 4-TM potassium channel protein family potassium channel protein like F21C3.2 F21C3.2 Protein containing a tyrosinase central domain, which are copper-binding domains, has a region of low similarity to a region oftyrosinase (human TYR), which is required for melanin synthesis and is associated with type I oculocutaneous albinism tyrosinase F21C3.3 F21C3.3 Protein with high similarity to histidine triad nucleotide-binding protein (protein kinase C interacting protein 1, human HINT1), which binds zinc and hydrolyzes adenosine polyphosphates in vitro, member of the histidine triad (HIT) family protein kinae C inhibitor 1 like; This gene encodes a protein predicted by Eisenberg and coworkers, with 68% accuracy, to be mitochondrial. F21C3.4 F21C3.4 Protein of unknown function Uncloned locus that is required for the functional silencing of chromosomal loci by transgenes (cosuppression) and promotes the effects of RNAi in a step after the formation of a heritable interfering agent, also affects X-chromosome nondisjunction and transposon activation; functions downstream of rde-1 in the RNAi pathway most effective against RNAi against germline but not somatically expressed genes. F21C3.5 F21C3.5 Member of the KE2 gene product family Mouse KE2 protein like F21C3.6 F21C3.6 Protein of unknown function F21D12.1 nhr-21;F21D12.1 Protein containing two nuclear hormone receptor C4-type zinc finger domains and two nuclear hormone receptor ligand-binding domains, has weak similarity to nuclear receptor subfamily 2 group E member 3 (human NR2E3), which is retinal-specific modulating N-terminal of steroid/thyroid/retinoic nuclear hormone receptors F21D12.2 F21D12.2 Protein of unknown function F21D12.3 F21D12.3 Member of the transmembrane amino acid transporter (permease) family, has moderate similarity to uncharacterized C. elegans Y4C6B.G F21D12.5 npx-1;F21D12.5 One member of a four protein Pax-like gene family, termed the Npax family, in C. elegans; the protein contains only the N-terminal PAI subdomain of the Paired domain Paired box protein F21D5.1 F21D5.1 Protein containing a phosphoglucomutase or phosphomannomutase alpha-beta-alpha domain II and C-terminal domain, has moderate similarity to hexosephosphate mutase (phosphoacetylglucosamine mutase, N-acetylglucosamine-phosphate mutase, S. cerevisiae Pcm1p) phosphoacetylglucosamine mutase F21D5.2 F21D5.2 Member of the ovarian tumor (OTU)-like cysteine protease family, has low similarity to uncharacterized human LOC51633 Yeast YHB3-like protein F21D5.3 F21D5.3 Member of the multicopper oxidase type 1 family, has low similarity to S. cerevisiae Fet3p, which is a cell surface ferroxidase that is required for high-affinity ferrous iron uptake laccase like copper oxidase F21D5.4 F21D5.4 Protein with moderate similarity to C. elegans Y48G1B_55.E DNA binding protein F21D5.5 F21D5.5;4J500 Protein with high similarity to polynucleotide kinase 3'-phosphatase (human PNKP), which has 5'-DNA kinase and 3'-phosphatase activities and functions in the repair of DNA strand breaks due to oxidative damage polynucleotide kinase 3' phosphatase F21D5.6 F21D5.6 Protein of unknown function F21D5.7 F21D5.7 Protein with high similarity to signal recognition particle 54 (human SRP54), contains one SRP54-type protein GTPase domain, one signal peptide binding (SRP54) M domain, and one signal recognition particle 54 (SRP54)-type protein helical bundle domain signal recognition particle protein (SRP54) F21D5.8 F21D5.8 Possible small ribosomal subunit protein F21D5.9 F21D5.9 Protein of unknown function Zinc finger, C2H2 type F21D9.1 F21D9.1 Protein containing an F-box domain, which serve as a link between a target protein and a ubiquitin-conjugating enzyme, has high similarity to uncharacterized C. elegans T02H6.5 This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins. F21D9.2 F21D9.2 Protein of unknown function, has low similarity to uncharacterized C. elegans W07E6.5 F21D9.3 F21D9.3 Protein of unknown function, has weak similarity to C. elegans F13E9.8 F21D9.4 F21D9.4 Protein of unknown function, has high similarity to uncharacterized C. elegans ZK228.3 F21D9.5 F21D9.5 Member of an uncharacterized protein family F21D9.6 F21D9.6 Protein containing an F-box domain, which serve as a link between a target protein and a ubiquitin-conjugating enzyme, has low similarity to uncharacterized C. elegans T26H2.2 F21D9.8 F21D9.8 Protein with moderate similarity to C. elegans ZC15.3 gene product F21E9.1 F21E9.1 Member of the reverse transcriptase protein family and member of the apurinic or apyrimidinic (AP) endonuclease family 1, has low similarity to uncharacterized C. elegans T19C9.7 F21E9.2 F21E9.2 Protein of unknown function, has weak similarity to C. elegans F59B10.3 F21E9.3 F21E9.3 Member of the transthyretin-like family, has moderate similarity to uncharacterized C. elegans JC8.8 F21E9.4 F21E9.4 Protein of unknown function F21E9.5 F21E9.5 Member of the reverse transcriptase protein family, which are RNA-dependent DNA polymerases, has strong similarity to uncharacterized C. elegans F09C3.6 F21E9.6 F21E9.6 Protein of unknown function F21F12.1 F21F12.1 Protein of unknown function F21F3.1 F21F3.1 Protein containing three NHL repeats, which are often associated with RING finger and B-box motifs, has moderate similarity to a region of peptidylglycine alpha-amidating monooxygenase (mouse Pam), which alpha-amidates neuroendocrine peptides F21F3.2 F21F3.2 Protein containing a protein kinase domain, has low similarity to S. cerevisiae Rim11p, which is required for induction of IME2 by Ime1p ser/thr-protein kinase F21F3.3 F21F3.3 Protein with moderate similarity to farnesyl cysteine carboxyl methyltransferase (S. pombe Mam4p), which is required for the production of mature M-factor mating pheromone protein-S isoprenylsysteine O-methyltransferase F21F3.4 F21F3.4 Protein of unknown function F21F3.5 unc-38;F21F3.5 Nicotinic acetylcholine receptor alpha subunit ligand-gated ionic channel; unc-38 encodes an alpha subunit of the nicotinic acetylcholine receptor (nAChR) superfamily; UNC-38 is required for normal locomotion and egg-laying, and functions as a subunit of a ligand-gated ion channel that likely mediates fast actions of acetylcholine at neuromuscular junctions and in the nervous system; when coexpressed with UNC-29 and LEV-1, non-alpha nAChR subunits, the resulting multimer can form levamisole-gated channels. F21F3.6 F21F3.6 Protein of unknown function, has weak similarity to C. elegans C05E11.3 F21F8.1 F21F8.1 Protein with similarity to G protein-coupled receptors of the SRG subfamily, no homolog found in human or D. melanogaster, may have fewer than 7 predicted transmembrane domains 7TM chemoreceptor, srg family F21F8.10 F21F8.10 Member of the 7-transmembrane chemoreceptor family of G protein-coupled receptors (GPCR), has high similarity to uncharacterized C. elegans F21F8.9 7TM chemoreceptor, str family F21F8.11 F21F8.11 Member of the sugar (and other) transporter family, has low similarity to human SLC17A7, which is a brain-specific Na+-dependent inorganic phosphate cotransporter that localizes exclusively to neuron-rich regions This gene encodes a protein predicted by Eisenberg and coworkers, with 52% accuracy, to be mitochondrial. F21F8.2 F21F8.2 Member of the aspartyl (acid) protease family, which include pepsins, cathepsins and renins, has moderate similarity to a region of C. elegans ASP-5 protease F21F8.3 asp-5;F21F8.3 Probable aspartyl protease protease F21F8.4 F21F8.4 Protein with high similarity to C. elegans ASP-6, which is aspartic-type endopeptidase involved in protein degradation, member of the aspartyl (acid) protease family, which include pepsins, cathepsins and renins protease F21F8.6 F21F8.6 Protein with high similarity to C. elegans ASP-6, which is an aspartic-type endopeptidase involved in protein degradation, member of the aspartyl (acid) protease family, which include pepsins, cathepsins and renins protease F21F8.7 asp-6;F21F8.7 Probable aspartyl protease protease; aspartic protease. F21F8.9 F21F8.9 Member of the 7-transmembrane chemoreceptor family of G protein-coupled receptors (GPCR), has low similarity to C. elegans ODR-10, which is a G protein-coupled receptor involved in odorant response 7TM chemoreceptor, str family F21G4.1 F21G4.1 Protein containing an organic anion transporter polypeptide (OATP) family N-terminus domain and an OATP family C-terminus domain, has low similarity to solute carrier family 21 (human SLC21A2), which transports many different prostaglandins Rat prostoglandin transporter like F21G4.2 F21G4.2 Member of the ABC transporter family, which mediate membrane transport, contains an ABC transporter transmembrane domain, has moderate similarity to ATP-binding cassette subfamily C member 1a (multiple drug resistance-associated protein, mouse Abcc1a) multidrug resistance-associated protein; The mrp-4 gene encodes a homolog of human CFTR, which when mutated leads to cystic fibrosis (OMIM:219700). F21G4.3 F21G4.3 Member of the domain of unknown function DUF13 family, has weak similarity to uncharacterized C. elegans C13A2.10 F21G4.4 F21G4.4 Protein containing a PHD-finger, which may be involved in chromatin-mediated transcriptional regulation F21G4.5 F21G4.5 Protein of unknown function, has low similarity to uncharacterized C. elegans K04C1.3 F21G4.6 F21G4.6 Protein of unknown function F21G4.6 is orthologous to the human gene HUNTINGTIN (HD; OMIM:143100), which when mutated leads to disease. F21H11.2 F21H11.2 Protein of unknown function, has low similarity to uncharacterized human 13CDNA73 F21H11.3 tbx-2;F21H11.3 Member of the T-box protein family tbx-2 is orthologous to the human gene T-BOX 3 (TBX3; OMIM:601621), which when mutated leads to ulnar mammary syndrome. F21H12.1 F21H12.1 Protein containing three WD domains (WD-40 repeat), which may mediate protein-protein interactions, has moderate similarity to human RBBP5, which binds preferentially to the E1A-binding pocket B of underphosphorylated retinoblastoma protein F21H12.2 F21H12.2 Protein of unknown function, has moderate similarity to C. elegans ZK675.1 F21H12.3 F21H12.3 Protein of unknown function, has a region of strong similarity to a region of C. elegans PTC-1, which is involved in patterning within segments F21H12.4 ptc-2;F21H12.4 Member of the patched family, which are transmembrane receptors, has high similarity to a region of C. elegans PTC-1, which is involved in patterning within segments membrane protein patched (ptc) F21H12.5 fbf-2;F21H12.5 RNA-binding protein involved in sex determination fbf-2 encodes an RNA-binding protein that is one of 11 C. elegans members of the PUF family (Pumilio and FBF) of translational regulators; FBF-2 is nearly identical to FBF-1 with which it is largely redundant in regulating two aspects of germline development: 1)maintenance of stem cell proliferation, and 2)the hermaphroditic switch between spermatogenesis and oogenesis; in maintaining germline stem cells, the FBF proteins, acting through NOS-3, negatively regulate the activity of gld-1 mRNA, which encodes a translational repressor required for meiotic entry; in regulating the sperm-to-oocyte switch, the FBFs act downstream of GLD-3 to negatively regulate the activity of fem-3 mRNA, which encodes a novel protein required for germline sex determination; consistent with their role in germline development, FBF-1 and FBF-2 are expressed in the germline cytoplasm, becoming enriched in the mitotic region during the L4 larval and adult stages. F21H12.6 F21H12.6 Protein with moderate similarity to tripeptidyl peptidase (rat Tpp2), which is a serine exopeptidase that inactivates cholecystokinin Tripeptidyl-peptidase II F21H7.1 F21H7.1 Protein containing glutathione S-transferase N-terminal and C-terminal domains, has low similarity to prostaglandin D2 synthase (human PGDS), which is a prostaglandin D synthase and glutathione S-transferase that regulates non-rapid eye movement sleep glutathione S-transferase F21H7.10 F21H7.10 Protein with weak similarity to beta-1,3-N-acetylglucosaminyltransferase (human B3GNT6), which catalyzes the synthesis and addition of poly-N-acetyllactosamine to branched carbohydrate acceptors of both N- and O-linked carbohydrates as well as glycolipids F21H7.11 F21H7.11 Putative ortholog of C. elegans F49H6.4 gene product F21H7.2 F21H7.2 Protein of unknown function F21H7.3 F21H7.3 Protein of unknown function F21H7.4 F21H7.4 Protein containing a C-type lectin domain, which mediate calcium-dependent carbohydrate recognition, has high similarity to uncharacterized C. elegans F17B5.5 F21H7.5 F21H7.5 Protein containing a major sperm protein (MSP) domain, which are involved in sperm motility, has strong similarity to uncharacterized C. elegans F36D3.4 F21H7.7 F21H7.7 Member of the 7-transmembrane chemoreceptor family of G protein-coupled receptors (GPCR), has moderate similarity to uncharacterized C. elegans T27C5.1 G-protein coupled receptor, srh family F21H7.9 gcy-20;gcy-16;F21H7.9 Protein containing two receptor family ligand binding domains, an adenylate and guanylate cyclase catalytic domain, and a protein kinase domain, has low similarity to natriuretic peptide receptor A (mouse Npr1) guanylate cyclase; gcy-20 encodes a predicted guanylate cyclase. F22A3.1 F22A3.1 Protein containing a sterile alpha motif (SAM) or pointed domain, which are a type of SAM domain in nuclear and signalling proteins, and an ETS domain, which bind promoter DNA, has low similarity to a region of prostate-derived Ets factor (mouse Pdef) DNA binding protein, ETS domain F22A3.2 F22A3.2 Member of the transthyretin-like family, has low similarity to uncharacterized C. elegans T08A9.2 F22A3.3 glr-8;F22A3.3 Protein containing a ligand-gated ion channel domain, which are found in ionotropic glutamate receptors and NMDA receptors, has low similarity to a region of kainate-selective ionotropic glutamate receptor 5 (rat Grik5), which acts in neurotransmission glutamate receptor F22A3.4 F22A3.4 Protein of unknown function F22A3.5 F22A3.5 Protein containing a homeobox domain (homeodomain), which are found in transcription factors, has a region of moderate similarity to a region of C. elegans CEH-20, which is a homeodomain transcription factor homeotic protein PBX2 F22A3.6 F22A3.6 Possible lysozyme, member of an uncharacterized protein family F22B3.1 F22B3.1 Protein with very strong similarity to H4 histone family member E (human H4FE), which may play a role in the establishment and or maintenance of chromatin architecture in nucleosomes, member of the histone family of nucleosomal core proteins histone H4; his-64 encodes an H4 histone. F22B3.2 F22B3.2 Histone H3 in the HIS3 gene cluster histone H3; his-63 encodes an H3 histone; by homology, HIS-63 is predicted to function as a nucleosome component required for packaging of DNA into chromatin; his-63 is a replication-dependent histone locus. F22B3.3 F22B3.3 Member of the reverse transcriptase protein family, which are RNA-dependent DNA polymerases, has very strong similarity to uncharacterized C. elegans C49A1.8 reverse transcriptase F22B3.4 F22B3.4 Protein with strong similarity to C. elegans F07A11.2, which is involved in gametogenesis, contains two sugar isomerase (SIS) domains, which bind phosphosugars, and a glutamine amidotransferases class II (purF-type) domain glucosamine-fructose-6-phosphate aminotransferase F22B3.5 F22B3.5 Protein of unknown function, has moderate similarity to C. elegans Y77E11A_3443.O F22B3.6 F22B3.6 Member of the reverse transcriptase protein family, which are RNA-dependent DNA polymerases, has very strong similarity to uncharacterized C. elegans F28E10.3 RNA-directed DNA polymerase F22B3.7 F22B3.7 Protein of unknown function, has moderate similarity to uncharacterized C. elegans Y77E11A.8 F22B3.8 F22B3.8 Protein containing one protein kinase and one Src homology 2 (SH2) domain, has a region of low similarity to a region of IL2-inducible T-cell kinase (human ITK), which is involved in T cell activation and cell-matrix adhesion tyrosine-protein kinase F22B5.1 F22B5.1 Protein with high similarity to ADP-ribosylation factor like 2 (mouse Arl2), member of the ADP-ribosylation factor (ARF) family, which are GTP-binding proteins involved in protein trafficking GTP-binding ADP-ribosylation factor; evl-20 encodes a functional ortholog of human ADP-ribosylation factor-like protein 2 (ARL2; OMIM:601175), with evl-20(ar103) mutants being rescued by transgenic human ARL2 but not ARL1 or ARL3-7; EVL-20 is required for cortical microtubule formation during cytokinesis and morphogenesis; EVL-20 is required for vulval, gonadal, and male tail development, as well as for embryonic mitosis, hypodermal enclosure, and elongation; EVL-20 is expressed in migrating hypodermal embryonic cells, larval vulval and somatic gonad cells, larval and adult neurons, and adult male proctodeal cells, being subcellularly associated with both the cell cortex and astral microtubules. F22B5.10 F22B5.10 Protein of unknown function, has strong similarity to human HS.93832 F22B5.2 F22B5.2 Protein with strong similarity to translation initiation factor eIF3 subunit RNA binding protein; eif-3. F22B5.3 F22B5.3 Protein with high similarity to C. elegans CUT-1, which is a cuticulin component cuticulin F22B5.4 F22B5.4 Protein of unknown function; mRNA is hypoxia inducible; has moderate similarity to C. elegans F36A2.7 F22B5.5 F22B5.5 Protein of unknown function, has low similarity to uncharacterized C. elegans C28D4.8 F22B5.6 F22B5.6 Protein of unknown function F22B5.8 zyg-9;F22B5.7;F22B5.8 Component of meiotic and mitotic spindle poles; member of the microtubule-associated protein (MAP) protein family F22B5.9 F22B5.9 Protein with high similarity to phenylalanyl-tRNA synthetase beta-subunit (human FRSB), which is a regulatory subunit that forms heterodimers with the catalytic alpha subunit that is involved in protein synthesis and may play a role in tumorigenic events phenylalanyl-tRNA synthetase F22B7.1 F22B7.1 Protein of unknown function F22B7.10 dpy-19;F22B7.10 Protein of unknown function, has moderate similarity to uncharacterized human KIAA0877 The dpy-19 gene encodes a novel transmembrane protein whose human homolog is expressed in brain, and that is required for correct polarization and migration of the neuroblasts QL and QR. F22B7.13 F22B7.13 Protein of unknown function, putative paralog of C. elegans C38C10.4 F22B7.2 F22B7.2 Protein of unknown function F22B7.3 F22B7.3 Protein of unknown function F22B7.4 F22B7.4 Protein of unknown function Environmental stress F22B7.5 F22B7.5 Protein containing two DnaJ domains, two cysteine-rich DnaJ central domains, and two DnaJ C-terminal domains, has moderate similarity to dnaJ homolog subfamily A member 3 (human DNAJA3), which is involved in protein folding and apoptosis control This gene encodes a protein containing a DnaJ ('J') domain that is predicted to be mitochondrial. F22B7.6 F22B7.6 Member of the impB, mucB or samB family, which are involved in UV protection, has moderate similarity to a region of DNA polymerase kappa (human POLK), which is a low fidelity DNA polymerase that functions in translesion DNA replication mucb F22B7.7 twk-8;F22B7.7 Member of the 4 TM potassium channel protein family Potassium channel protein F22B7.8 F22B7.8 Protein of unknown function, has weak similarity to C. elegans T12C9.3 F22B7.9 F22B7.9 Protein with weak similarity to C. elegans K01A11.2 F22B8.1 F22B8.1 Member of the 7-transmembrane chemoreceptor family of G protein-coupled receptors (GPCR), has high similarity to uncharacterized C. elegans T01G5.3 7TM receptor F22B8.3 F22B8.3 Member of the 7-transmembrane chemoreceptor family of G protein-coupled receptors (GPCR), has low similarity to C. elegans ODR-10, which is a G protein-coupled receptor involved in odorant response F22B8.4 F22B8.4 Member of an uncharacterized protein family F22B8.5 F22B8.5 Member of the 7-transmembrane chemoreceptor family of G protein-coupled receptors (GPCR), has high similarity to uncharacterized C. elegans F57A10.1 7TM receptor F22B8.6 F22B8.6 Protein with high similarity to cystathionase (human CTH), which is a pyridoxal phosphate-dependent enzyme that catalyzes the conversion of cystathionine to cysteine, member of the cysteine-methionine metabolism pyridoxal-phosphate-dependent enzyme family cystathione gamma-lyase like F22B8.7 F22B8.7 Protein of unknown function, has strong similarity to uncharacterized C. elegans F53E10.1 F22D3.1 ceh-38;F22D3.1 Homeodomain transcription factor; has similarity to human HNF6A hepatocyte nuclear factor alpha and OC-2 (ONECUT-2), homeodomain transcription factors with function in liver cells homeobox protein; ceh-38 encodes two proteins, by alternative splicing, that belong to the ONECUT class of homeodomain proteins (which includes mammalian hepatocyte nuclear factor-6); ceh-38 is expressed from embryos to adults, and in many different tissues (e.g., pharynx, gut, hypodermis and many nerve cells), but has no known function in vivo. F22D3.2 F22D3.2 Putative ortholog of C. elegans F22D3.3 gene product F22D3.4 F22D3.4 Protein of unknown function, has weak similarity to C. elegans T22B11.1 F22D3.5 F22D3.5 Protein of unknown function, has weak similarity to C. elegans C29F9.12 F22D3.6 paracaspase;F22D3.6 Protein of unknown function, has low similarity to a region of mucosa associated lymphoid tissue lymphoma translocation gene 1 (human MALT1), which activates NF-kappaB mediated signaling either in a complex with BCL10 or as a fusion product with BIRC3 The F22D3.6 gene encodes a paracaspase homolog that may be involved in apoptosis, and that is orthologous to the human gene MUCOSA ASSOCIATED LYMPHOID TISSUE LYMPHOMA TRANSLOCATION GENE 1 (MALT1; OMIM:604860). F22D6.1 kin-14;F22D6.1 Protein containing one protein kinase domain and one Src homology 2 (SH2) domain, which are regulatory modules of intracellular signaling, has moderate similarity to fer (fps/fes related) tyrosine kinase (mouse Fert2), which is involved in male meiosis Src homology domain 2, tyrosine-protein kinase (FES/FPS subfamily); kin-14 encodes a member of the tyrosine-specific subfamily of kinases that contains an SH2 domain, and has with similarity to the human proto-oncogene tyrosine-protein kinase FER. F22D6.10 F22D6.10 Protein containing two collagen triple helix repeats and one nematode cuticle collagen N-terminal domain, has moderate similarity to C. elegans ROL-6, which is a putative collagen that functions in morphogenesis of the epithleum and cuticle synthesis collagen F22D6.11 gly-18;F22D6.11 Member of the core-2 or I-branching enzyme family, which form blood group I-antigens or side-chains of O-glycans, has low similarity to beta-1 6-N-acetylglucosaminyltransferase-mucin type (human GCNT3), which plays a role in O-glycan synthesis in mucins beta-1,6-N-acetylglucosaminyltransferase; GLY-18 is similar to 2/I N-acetylglucosaminyltransferase. F22D6.12 gly-19;F22D6.12 Member of the core-2 or I-branching enzyme family, has low similarity to core 2 beta-1,6-N-acetylglucosaminyltransferase-leukocyte type (human GCNT1), which forms O-glycan structures and is associated with Wiskott-Aldrich syndrome and multiple sclerosis beta-1,6-N-acetylglucosaminyltransferase; gly-19 encodes a protein similar to 2/I N-acetylglucosaminyltransferase; it is probably coexpressed with gly-18 in the anal sphincter muscle. F22D6.14 F22D6.14 Protein of unknown function, putative paralog of C. elegans B0393.8 F22D6.2 F22D6.2 Protein containing an A20-like zinc finger domain and an AN1-like zinc finger domain, has moderate similarity to uncharacterized human ZNF216 F22D6.3 F22D6.3 Protein with high similarity to asparaginyl-tRNA synthetase (human NARS), which is an autoantigen that is associated with interstitial lung disease, contains a class II asparagine, aspartic acid and lysine tRNA synthetase domain and an OB-fold domain asparaginyl-tRNA synthetase F22D6.4 F22D6.4 Protein of unknown function, has a region of high similarity to rat Ndufs6, which is a subunit of the NADH-ubiquinone oxidoreductase complex I that transports electrons from NADH to ubiquinone NADH_ubiquinone oxidoreductase subunit F22D6.5 F22D6.5 Protein containing two protein kinase domains, has moderate similarity to pre-mRNA processing 4 (human PRP4), which is a nuclear serine-threonine kinase activated by EGF stimulation that functions in transcriptional regulation serine/threonine kinase F22D6.6 F22D6.6 Protein containing two tudor domains, which are found in proteins involved in RNA localization, has weak similarity to uncharacterized C. elegans Y38F2AR F22D6.7 F22D6.7 Protein of unknown function, has weak similarity to C. elegans F31E3.6 F22D6.9 F22D6.9 Serine/threonine protein phosphatase serine/threonine protein phosphatase F22E10.1 F22E10.1 Member of the ABC transporter family, which are involved in translocation of a variety of compounds across biological membranes, contains two ABC transporter transmembrane domains, has moderate similarity to C. elegans PGP-1 p-glycoprotein (MDR) F22E10.2 F22E10.2 Member of the ABC transporter family, which are involved in translocation of a variety of compounds across biological membranes, contains two ABC transporter transmembrane domains, has moderate similarity to C. elegans C47A10.1 p-glycoprotein (MDR); pgp-13 encodes a member of the ABC transporter family with high similarity to the vertebrate MDR (multidrug resistance) family. F22E10.3 F22E10.3 Member of the ABC transporter family, which are involved in translocation of a variety of compounds across biological membranes, contains two ABC transporter transmembrane domains, has moderate similarity to C. elegans PGP-1 p-glycoprotein (MDR); pgp-14 encodes a member of the ABC transporter family with highest similarity to the vertebrate MDR (multidrug resistance) family. F22E10.4 F22E10.4 Member of the ABC transporter family, which are involved in translocation of a variety of compounds across biological membranes, contains an ABC transporter transmembrane domain, has moderate similarity to C. elegans C47A10.1 p-glycoprotein (MDR) F22E10.5 F22E10.5 Protein with high similarity to choline-ethanolaminephosphotransferase (human CEPT1), which catalyzes a step in the formation of phosphatidylcholine or phosphatidylethanolamine, member of the CDP-alcohol phosphatidyltransferase family phosphotransferase F22E12.1 F22E12.1 Member of the serine carboxypeptidase family, contains two kunitz or bovine pancreatic trypsin inhibitor domains, has a region of low similarity to carboxypeptidase Y (CPY/yscY, S. cerevisiae Prc1p), which is a vacuolar serine protease F22E12.2 F22E12.2 Protein with high similarity to cdc42Hs homologue protein (rat Rn.30047), which is a putative RHO GTPase that activates JNK MAP kinase signaling and regulates reorganization of the actin cytoskeleton, member of the Ras superfamily of GTP-binding proteins RAS related protein F22E12.3 F22E12.3 Protein with moderate similarity to C. elegans T24C12.4 gene product F22E12.4 egl-9;F22E12.4 Dioxygenase; regulates hypoxia inducible factor-1 (HIF-1) by prolyl hydroxylation; has weak similarity to C. elegans R06F6.4 egl-9 encodes a dioxygenase that negatively regulates hypoxia inducible factor (hif-1) by hydroxylating prolyl residues in HIF-1. F22E5.1 F22E5.1 Protein containing a DUF235 domain of unknown function, has high similarity to uncharacterized C. elegans C16D9.5 F22E5.10 F22E5.10 Member of the 7-transmembrane chemoreceptor family of G protein-coupled receptors (GPCR), has moderate similarity to uncharacterized C. elegans Y27F2A.3 F22E5.11 F22E5.11 Protein containing a K+ channel tetramerization domain, which facilitate assembly of alpha-subunits into functional tetrameric channels F22E5.12 F22E5.12 Protein containing a K+ channel tetramerization domain, which facilitate assembly of alpha-subunits into functional tetrameric channels, has moderate similarity to a region of NY-REN-45 tumor antigen (human LOC51133) F22E5.13 F22E5.13 Protein of unknown function, has strong similarity to C. elegans ZC239.6 F22E5.14 F22E5.14 Member of the 7-transmembrane chemoreceptor family of G protein-coupled receptors (GPCR) F22E5.15 F22E5.15 Member of the 7-transmembrane chemoreceptor family of G protein-coupled receptors (GPCR), has high similarity to uncharacterized C. elegans T10D4.8 F22E5.16 F22E5.16 Member of the 7-transmembrane chemoreceptor family of G protein-coupled receptors, contains an F-box domain, which serve as a link between a target protein and ubiquitin-conjugating enzyme, has strong similarity to uncharacterized C. elegans Y27F2A.2 7TM chemoreceptor, sri family F22E5.17 F22E5.17 Protein of unknown function F22E5.18 F22E5.18 Putative ortholog of C. elegans F22E5.16 gene product F22E5.2 F22E5.2 Protein of unknown function, has weak similarity to C. elegans R52.6 F22E5.3 gcy-21;F22E5.3 Protein containing two protein kinase domains and an adenylate and guanylate cyclase catalytic domain, has a region of moderate similarity to a region of natriuretic peptide receptor A (human NPR1), which is a membrane-bound guanylate cyclase protein kinase; gcy-21 is predicted to encode a guanylate cyclase. F22E5.4 F22E5.4 Member of the 7-transmembrane chemoreceptor family of G protein-coupled receptors (GPCR), has high similarity to uncharacterized C. elegans ZC239.9 7TM chemoreceptor, sri family F22E5.5 F22E5.5 Member of the 7-transmembrane chemoreceptor family of G protein-coupled receptors (GPCR), has high similarity to uncharacterized C. elegans ZC239.8 F22E5.6 F22E5.6 Protein containing a K+ channel tetramerization domain, which facilitate assembly of alpha-subunits into functional tetrameric channels, has strong similarity to uncharacterized C. elegans ZC239.12 F22E5.7 F22E5.7 Protein of unknown function, has weak similarity to C. elegans F17E9.4 F22E5.8 F22E5.8 Protein containing a K+ channel tetramerization domain, which facilitate assembly of alpha-subunits into functional tetrameric channels, has high similarity to uncharacterized C. elegans ZC239.15 F22E5.9 F22E5.9 Protein with strong similarity to C. elegans Y27F2A.C gene product F22F1.1 H1.3;F22F1.1 Protein with high similarity to histone H1 21.5 kDa form (C. elegans HIS-24), member of the histone H1 and H5 family of linker histones histone h1 F22F1.2 F22F1.2 Protein containing a protein kinase domain, has low similarity to S. pombe Hhp1p, which is a casein kinase I (CKI) that is required for DNA repair ser/thr protein kinase F22F1.3 F22F1.3 Protein containing two KIX domains, which bind transcription factor transactivation domains, has a region of moderate similarity to a region of C. elegans CBP-1, which is a transcriptional activator that may be involved in cell differentiation mouse CREB-binding protein; human transcriptional adaptor protein p300 F22F4.1 F22F4.1 Putative ortholog of C. elegans C09B8.2 gene product F22F4.2 inx-3;opu-3;F22F4.2 Innexin that forms connexin-like intercellular channels unc-7-like protein F22F4.3 klp-13;F22F4.3 Protein containing two kinesin motor domains, which binds ATP and microtubules, has a region of low similarity to a region of S. cerevisiae Kip3p, which is a kinesin-related protein that is involved in pre-anaphase nuclear migration kinesin-like protein; klp-13 encodes an atypical kinesin-like motor protein similar to Saccharomyces cerevisiae Kip3, which has been implicated in nuclear migration; as loss of KLP-13 function via RNA-mediated interference (RNAi) does not result in any abnormalities, the precise role of KLP-13 in C. elegans development and/or behavior is not yet known. F22F4.4 F22F4.4 Protein of unknown function F22F7.1 F22F7.1 Protein of unknown function, has high similarity to uncharacterized C. elegans Y50D4B.2 F22F7.2 F22F7.2 Protein of unknown function, has high similarity to uncharacterized C. elegans F22F7.1 F22F7.3 F22F7.3 Member of an uncharacterized protein family F22F7.4 F22F7.4 Member of an uncharacterized protein family F22F7.5 F22F7.5 Member of the choline or ethanolamine kinase family, which catalyze the formation of phosphatidylcholine by the CDP-choline pathway, has low similarity to choline kinase (mouse Chk), which catalyzes the first step in the CDP-choline pathway choline kinase F22F7.6 F22F7.6 Protein with weak similarity to beta-1,3-N-acetylglucosaminyltransferase (human B3GNT6), which catalyzes the synthesis and addition of poly-N-acetyllactosamine to branched carbohydrate acceptors of both N- and O-linked carbohydrates as well as glycolipids F22F7.7 F22F7.7 Protein of unknown function, has moderate similarity to uncharacterized human MGC4504 F22G12.1 F22G12.1 Protein of unknown function, has low similarity to uncharacterized C. elegans C17H1.4 F22G12.2 F22G12.2 Protein containing a retroviral integrase core domain, which are the central catalytic domains that can act as endonucleases F22G12.3 F22G12.3 Protein containing an F-box domain, which serve as a link between a target protein and a ubiquitin-conjugating enzyme This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins. F22G12.4 F22G12.4 Protein containing eighteen ankyrin (Ank) repeats, which may mediate protein-protein interactions, and a FYVE zinc finger domain, which bind phosphatidylinositol 3-phosphate, has weak similarity to a region of ankyrin 1 (human ANK1) Ank repeat (6 domains) F22G12.5 F22G12.5 Protein containing a pleckstrin homology (PH) domain, which mediate protein-protein and protein-lipid interactions F22G12.6 F22G12.6 Protein of unknown function F22H10.1 F22H10.1 Protein containing two protein kinase domains, has a region of low similarity to a region of casein kinase 1 alpha 1 (human CSNK1A1), which is a serine-threonine protein kinase that may be associated with Alzheimer's disease protein kinase F22H10.2 F22H10.2 Protein of unknown function F22H10.3 F22H10.3 Protein of unknown function F22H10.4 F22H10.4 Protein of unknown function, has strong similarity to C. elegans F13A7.7 F22H10.5 F22H10.5 Protein of unknown function, has moderate similarity to a region of germ cell-specific gene 2 (haspin, mouse Gsg2), which is a serine-threonine kinase that binds DNA and may play roles in cell cycle cessation and haploid germ cell differentiation F22H10.6 F22H10.6 Protein of unknown function, has weak similarity to C. elegans F31A3.3 F23A7.1 F23A7.1 Protein of unknown function F23A7.3 F23A7.3 Protein of unknown function, putative paralog of C. elegans C44C10.2 cytochrome P450 like F23A7.4 F23A7.4 Protein of unknown function glutamate receptor epsilon subunit like F23A7.5 F23A7.5 Member of the polypeptide chain release factor protein family F23A7.6 F23A7.6 Protein with moderate similarity to C. elegans T06G6.5 Zinc finger, C3HC4 type (RING finger) F23B12.1 F23B12.1 Protein with high similarity to S. cerevisiae Glc7p, which is a protein serine or threonine phosphatase required for glucose repression, membrane bilayer mixing and many other processes, member of the serine or threonine protein phosphatase family serine/threonine protein phosphatase F23B12.2 F23B12.2 Protein containing a DUF215 domain of unknown function, has moderate similarity to uncharacterized C. elegans T08G3.8 F23B12.3 F23B12.3 Protein containing a reeler domain F23B12.4 F23B12.4 Protein of unknown function F23B12.5 F23B12.5 Protein with high similarity to dihydrolipoamide acetyltransferase E2 (dihydrolipoyl acetyltransferase, human DLAT), contains a 2-oxo acid dehydrogenases acyltransferase catalytic domain, a biotin or lipoyl attachment domain, and an E3 binding domain dihyrolipoamide acetyltransferase component (pyruvate dehydrogenase complex); F23B12.5 is orthologous to the human gene DIHYDROLIPOAMIDE DEHYDROGENASE (DLD; OMIM:109720), which when mutated leads to lactic acidosis due to lipoamide dehydrogenase deficiency; F23B12.5 protein is predicted to be mitochondrial. F23B12.6 F23B12.6 Protein with high similarity to farnesyltransferase beta subunit (human FNTB), which is a subunit of the CAAX farnesyltransferase that transfers farnesyl groups to proteins, contains six prenyltransferase and squalene oxidase repeat domains protein farnesyltransferase beta subunit F23B12.7 F23B12.7 Protein with low similarity to CCAAT box binding transcription factor (human CBF2), which activates HSP70 transcription and functions in adenovirus E1A protein-dependent transcriptional activation and human TP53 -dependent HSP70 transcriptional repression CCAAT binding factor 1 protein like F23B12.8 klp-14;bmk1;F23B12.8 Protein containing a kinesin motor domain, which binds ATP and microtubules, has moderate similarity to kinesin-like 1 (human KNSL1), which acts in mitotic spindle formation and centrosome separation kinesin-like protein; a homolog of BimC kinesin; affects embryogenesis, spindle and chromosome positioning during early embryogenesis, and genetically interacts with air-2. F23B12.9 egl-1;F23B12.9 Activator of programed cell death programmed cell death activator (egl-1); egl-1 encodes a BH3-domain-containing (Bcl-2 homology region 3) protein that activates cell death, by interacting directly with CED-9 protein and inducing the release of CED-4 from CED-4/CED-9 complexes, activating CED-3 protease; EGL-1 also induces WAH-1 release from the mitochondria and, in hermaphrodites, is transcriptionally repressed by TRA-1 (which permits survival of the HSN neuron required for egg laying). F23B2.10 F23B2.10 Protein of unknown function, has weak similarity to C. elegans C53A5.6 F23B2.11 F23B2.11 Member of the alpha or beta hydrolase fold family, has a region of low similarity to dipeptidyl peptidase 7 (quiescent cell proline dipeptidase, human DPP7), which is a serine protease that cleaves N-terminal dipeptides and may play a role in apoptosis lysosomal carboxypeptidase F23B2.12 F23B2.12 Protein of unknown function, has a region of low similarity to dipeptidyl peptidase 7 (quiescent cell proline dipeptidase, human DPP7), which is a serine protease that cleaves N-terminal Xaa-Pro dipeptides lysosomal carboxypeptidase F23B2.13 F23B2.13 RNA polymerases I, II and III shared polypeptide (approx 7kd) RNA polymerases I, II and III shared polypeptide (approx 7kd) F23B2.3 F23B2.3 Member of the amiloride-sensitive sodium channel family, has similarity to human and D. melanogaster amiloride-sensitive cation channels amiloride-sensitive sodium channel F23B2.4 daf-10;osm-4;F23B2.4 Required for proper neuronal cilium development WD domain, G-beta repeats F23B2.5 flp-1;F23B2.5 FMRF-amide-like peptide neurotransmitter FMFRamide neuropeptide precursor; flp-1 can encode up to seven distinct, yet highly similar, FMRFamide-related peptides (FaRPs), small neuromodulatory peptides that are characterized by a C-terminal Arg-Phe-amide motif; in C. elegans, FLP-1 peptides are required for regulation of several behaviors, including well-coordinated, sinusoidal movement and the transition between active and inactive states of egg-laying; receptors for the FLP-1 peptides have not yet been identified, but genetic studies indicate that FLP-1 peptides may act through G-protein coupled receptors; flp-1 mRNAs are detected at all developmental stages, and a FLP-1 translational reporter fusion detects expression in the anteriorly positioned neurons AVK, AVA, AVE, RIG, RMG, AIY, AIA, and M5. F23B2.6 F23B2.6 Member of the RRM domain protein family vimentin like F23B2.7 F23B2.7 Protein of unknown function, has strong similarity to C. elegans C55C3.3 F23B2.8 F23B2.8 Protein with strong similarity to C. elegans F23B2.9 gene product F23B2.9 F23B2.9 Protein with strong similarity to C. elegans F23B2.8 gene product F23C8.3 F23C8.L;F23C8.3 Protein of unknown function F23C8.4 F23C8.K;F23C8.4 Protein containing a UBA (ubiquitin associated) or TS-N domain and a UBX domain, which are found in ubiquitin regulatory proteins F23C8.5 F23C8.G;F23C8.5 Protein with high similarity to electron transfer flavoprotein beta subunit (human ETFB), which shuttles electrons between flavoprotein dehydrogenases and ubiquinone oxidoreductase, member of the electron transfer flavoprotein (ETF) beta subunit family electron transfer flavoprotein beta; The F23C8.5 gene encodes an ortholog of the human gene ELECTRON TRANSFER FLAVOPROTEIN BETA SUBUNIT (ETFB), which when mutated leads to glutaricaciduria type IIB (OMIM:130410). F23C8.9 F23C8.9 Protein of unknown function F23C8.A F23C8.12;F23C8.A Protein with moderate similarity to C. elegans ZC395.11 gene product F23C8.B F23C8.11;F23C8.B Protein of unknown function, has low similarity to uncharacterized C. elegans F49C5.3 F23C8.D F23C8.8;F23C8.D Protein containing a protein kinase domain, has low similarity to serine threonine kinase 22b (mouse Stk22b), which is a serine/threonine kinase involved in the cytodifferentiation of late spermatids into sperm F23C8.E F23C8.7;F23C8.E Protein containing a protein kinase domain and a Src homology 2 (SH2) domain, which are regulatory modules of intracellular signaling, has moderate similarity to fer (fps/fes related) tyrosine kinase (mouse Fert2) F23C8.F F23C8.6;F23C8.F Protein with moderate similarity to S. cerevisiae Did2p, which is a class E vacuolar protein-sorting (vps) factor F23C8.M F23C8.1;F23C8.M Protein of unknown function F23D12.1 F23D12.1 Protein of unknown function, has weak similarity to C. elegans C49F5.7 F23D12.2 F23D12.2 Protein with moderate similarity to C. elegans C49F5.6 This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins; this gene's encoded protein also contains an FTH/DUF38 motif, which may also mediate protein-protein interaction. F23D12.3 F23D12.3 Protein of unknown function, has strong similarity to C. elegans F58E10.7 F23D12.4 F23D12.4 Protein of unknown function This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins. F23D12.5 F23D12.5 Protein containing a Jumonji (jmjC) domain, has low similarity to uncharacterized C. elegans C29F7.6 F23F1.1 F23F1.1 Protein of unknown function, has low similarity to a region of S. pombe Php5p, which is a subunit of CCAAT-binding factor that is required for growth on non-fermentable carbon sources F23F1.2 F23F1.2 Protein containing three EF hand domains, which are found in signaling, buffering or transport proteins F23F1.3 F23F1.3 Protein of unknown function, has weak similarity to C. elegans C46E10.5 F23F1.4 F23F1.4 Protein of unknown function F23F1.5 F23F1.5 Protein with moderate similarity to RNA-U transporter 1 (snuportin-1, human RNUT1), which functions as an snRNP-specific nuclear import receptor via binding m3G-cap structure and stimulates import of m3G-capped U snRNPs, bound and exported by human XPO1 F23F1.6 F23F1.6 Member of the amino acid permease family, putative ortholog of human cationic amino acid transporters SLC7A1 and SLC7A2 amino acid permease F23F1.7 F23F1.7 Protein of unknown function F23F1.8 rpt-4;F23F1.8 Putative ATPase subunit of 19S proteasome particle rpt-4 encodes a predicted ATPase subunit of the 19S regulatory complex of the proteasome that affects body morphology, embryonic viability, growth, movement, and fertility; interacts with itself in yeast two-hybrid assays. F23F1.9 F23F1.9 Protein of unknown function F23F12.1 F23F12.1 Putative member of the transporter protein family, has weak similarity to the C-terminal region of human and D. melanogaster organic cation transporters F23F12.10 srb-11;F23F12.10 G protein-coupled receptor; member of a subfamily with SRB proteins, which are expressed in chemosensory neurons; no homolog found in human or D. melanogaster 7TM chemoreceptor, srb family F23F12.11 srb-10;F23F12.11 G protein-coupled receptor; member of a subfamily with SRB proteins, which are expressed in chemosensory neurons; no homolog found in human or D. melanogaster F23F12.12 F23F12.12 Protein of unknown function F23F12.2 F23F12.2 Protein of unknown function F23F12.3 F23F12.3 Small protein with similarity to organic cation transporters F23F12.4 F23F12.4 Member of the F-box domain protein family This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins. F23F12.6 rpt-3;F23F12.6 Putative ATPase subunit of 19S proteasome particle rpt-3 encodes a triple A ATPase subunit of the 26S proteasome's 19S regulatory particle (RP) base subcomplex; RPT-3 is required for embryonic, larval, and germline development and by homology, is predicted to function in unfolding protein substrates and translocating them into the core proteolytic particle (CP) of the proteasome. F23F12.7 F23F12.7 Protein of unknown function F23F12.8 F23F12.8 Putative coiled-coil containing protein, has moderate similarity S. cerevisiae USO1 gene product [Coiled-coil protein with similarity to mammalian integrin, required for protein transport from ER to Golgi] F23F12.9 F23F12.9 Protein with weak similarity to C. elegans ces-2 (Putative transcriptional repressor) F23H11.1 bra-2;F23H11.1 Protein containing an MYND finger domain, has a region of low similarity to a region of adenovirus 5 E1A binding protein (human BS69), which represses human MYB and adenovirus E1A-activated transcription F23H11.2 F23H11.2 Protein of unknown function F23H11.3 F23H11.3 Protein with high similarity to succinyl-CoA synthetase alpha subunit (rat Suclg1), which acts in the tricarboxylic acid cycle, member of the ATP-citrate lyase or succinyl-CoA ligase family, contains one CoA binding domain succinyl-CoA ligase; This gene encodes a protein predicted by Eisenberg and coworkers, with 68% accuracy, to be mitochondrial. F23H11.4 F23H11.4 Protein containing a RhoGAP (GTPase activator protein) and two pleckstrin homology (PH) domains, which mediate protein-protein and protein-lipid interactions, has region of low similarity to a region of rho GTPase-activating protein 5 (mouse Arhgap5) F23H11.5 F23H11.5 Protein of unknown function The bra-2 gene encodes a homolog of the human BMP receptor-associated molecule (BRAM1), paralogous to bra-1, that may act upon the SMA-6 TGF-beta signalling pathway. F23H11.6 F23H11.6 Protein of unknown function F23H11.7 F23H11.7 Protein of unknown function F23H11.8 pef-1;ppef;F23H11.8 Member of the protein phosphatase protein family protein phosphatase; pef-1 encodes an ortholog of the rhodopsin-specific serine/threonine phosphatase RdgC in D. melanogaster and of RdgC-related proteins in humans (PPEF1 and PPEF2; OMIM:300109 and OMIM:602256); PEF-1 has a EF-hand calcium-binding domain, and is peripherally bound to the plasma membrane by myristoylation and palmitoylation; pef-1 has no known mutant phenotype, but is expressed in several anterior amphid neurons, from what appears to be the 3-fold embryo stage onward; on the basis of its expression and its orthology, PEF-1 may negatively regulate signalling through serpentine receptors such as STR-2. F23H11.9 F23H11.9 Member of the CDP-alcohol phosphatidyltransferase family, has low similarity to cardiolipin synthase (S. cerevisiae Crd1p), which synthesizes cardiolipin from phosphatidylglycerol and CDP-diacylglycerol This gene encodes a protein predicted by Eisenberg and coworkers, with 52% accuracy, to be mitochondrial. F23H12.1 F23H12.1;snb-2 Protein with high similarity to vesicle associated membrane protein 1 (synaptobrevin 1, rat Vamp1), which is involved in the targeting or fusion of transport vesicles to target membranes and synaptic vesicle exocytosis, member of the synaptobrevin family synaptobrevin like F23H12.2 F23H12.2 Member of the MAS20 protein import receptor family, which are components of the mitochondrial outer membrane receptor involved in protein targeting, has moderate similarity to uncharacterized human KIAA0016 mitochondrial precursor receptor F23H12.3 F23H12.3 Protein of unknown function F23H12.4 sqt-3;col-1;dpy-15;F23H12.4 Collagen collagen F23H12.5 F23H12.5 Protein of unknown function, contains a putative thrombospondin type 1 domain, has weak similarity to human KIAA0170 protein (Hs.169504) Thrombospondin type 1 domain F23H12.6 gcy-13;F23H12.6 Putative guanylyl cyclase guanylate cyclase (2 domains); gcy-13 encodes a predicted guanylate cyclase. F23H12.7 F23H12.7 Protein of unknown function F25A2.1 F25A2.1 Protein of unknown function, has moderate similarity to C. elegans T21H3.1 F25B3.1 F25B3.1 Protein containing a calponin homology (CH) domain, has a region of moderate similarity to a region of S. pombe Ain1p, which is an alpha-actinin-like protein that may be involved in organizing actin at the medial ring for cytokinesis and septation actin binding domain F25B3.2 F25B3.2 Protein of unknown function, has weak similarity to C. elegans Y95B8A_84.J F25B3.3 F25B3.3 Protein containing two EF hand domains, which are found in signaling or transport proteins, a ras guanine nucleotide exchange factor (GEF) domain, and a phorbol esters or diacylglycerol binding domain (C1 domain), has moderate similarity to human KIAA0846 phorbol ester and DAG binding domain F25B3.4 F25B3.4 PP1-type serine/threonine protein phosphatase serine/threonine protein phosphatase F25B3.5 F25B3.5 Protein of unknown function F25B3.6 F25B3.6 Protein containing one plus-3 domain, which may be involved in DNA binding, has low similarity to uncharacterized human KIAA0252 F25B4.1 F25B4.1 Protein with high similarity to glycine decarboxylase (aminomethyltransferase, human AMT), which acts in the glycine cleavage system and has a role in glycine encephalopathy, member of the glycine cleavage T-protein (aminomethyl transferase) family aminomethytransferase; F25B4.1 is orthologous to the human gene GLYCINE CLEAVAGE SYSTEM T-PROTEIN (AMT; OMIM:238310), which when mutated leads to glycine encephalopathy. F25B4.2 pellino;F25B4.2 Protein of unknown function, has moderate similarity to uncharacterized human PELI1 F25B4.4 F25B4.4 Protein of unknown function F25B4.5 F25B4.5 Protein of unknown function, has a region of weak similarity to a region of S. cerevisiae Prp39p, which is a U1 snRNA-associated protein required for commitment of pre-mRNA to the splicing pathway F25B4.6 F25B4.6 Putative hydroxymethylglutaryl-CoA synthase, has approximately equal similarity to mitochondrial and cytoplasmic hydroxymethylglutaryl-CoA synthases hydroxymethlglutaryl-CoA synthase; F25B4.6 is orthologous to the human gene 3-HYDROXY-3-METHYLGLUTARYL COA SYNTHASE (HMGCS2; OMIM:600234), which when mutated leads to disease. F25B4.7 F25B4.7 Protein with high similarity to solute carrier family 25 member 4 (rat Slc25a4), which is a heart-skeletal muscle adenine nucleotide translocator (ADP/ATP carrier), member of the mitochondrial carrier protein family of membrane transporters ADP. ATP carrier protein F25B4.8 F25B4.8 Protein of unknown function F25B4.9 F25B4.9 Protein containing putative C-type lectin domains, has weak similarity across the middle region to members of the C-type lectin family including C. elegans T19E7.1 and human FCER2 (Fc fragment of IgE, low affinity II, receptor for CD23A) (Hs.1416) F25B5.1 F25B5.1 Protein with weak similarity to H. sapiens GOLGA4 (golgi autoantigen, golgin subfamily a, 4) F25B5.2 F25B5.2 Protein of unknown function F25B5.3 F25B5.3 Protein of unknown function, has moderate similarity to uncharacterized human UMPH1 F25B5.4 ubq-1;UbiA;F25B5.4 Polyubiquitin F25B5.5 F25B5.5 Protein with high similarity to neuronal Cdk5 activator-binding protein (rat C42), which binds rat Nck5a and may be involved in neuronal differentiation, member of the uncharacterized protein family UPF0004, contains a TRAM domain F25B5.6 F25B5.6 Protein containing two Mur ligase family glutamate ligase and two Mur ligase family catalytic domains, which catalyze peptidoglycan synthesis, has moderate similarity to folylpolyglutamate synthase (folylpoly-gamma-glutamate synthetase, mouse Fpgs) tetrahydrofolylpolyglutamate synthase; This gene encodes a protein predicted by Eisenberg and coworkers, with 52% accuracy, to be mitochondrial. F25B5.7 F25B5.7 Protein containing two RNA recognition motifs (RRM, RBD, or RNP), has moderate similarity to a region of human SFPQ, which is a splicing factor that binds to polypyrimidine in introns to regulate splicing and is associated with renal cell carcinomas F25C8.1 F25C8.1 Member of the acyl-CoA oxidase family, which convert acyl-CoA into trans-2-enoyl-CoA, has moderate similarity to peroxisomal acyl-coenzyme A oxidase (rat RATACOA1), which catalyzes the first step in very long chain fatty acid beta-oxidation ACYL-COENZYME A OXIDASE, PEROXISOMAL (EC 1.3.3.6) (PALMITOYL-COA OXIDASE) (AOX) F25C8.2 F25C8.2 Member of the flavin containing amine oxidase family, has moderate similarity to uncharacterized C. elegans F55C5.6 F25C8.3 F25C8.3 Protein of unknown function F25C8.4 F25C8.4 Member of the AMP-binding enzyme family, has weak similarity to S. cerevisiae Fat2p, which is a peroxisomal AMP-binding protein AMP-binding enzymes; This gene encodes a protein predicted by Eisenberg and coworkers, with 52% accuracy, to be mitochondrial. F25D1.1 F25D1.1 Protein with high similarity to mouse Ppm1b, which is a protein phosphatase that dephosphorylates serine and threonine residues and plays a role in signal transduction, member of the protein phosphatase 2C family protein phosphatase F25D1.2 F25D1.2 Protein of unknown function F25D1.3 F25D1.3 Protein of unknown function F25D1.4 F25D1.4 Member of the amiloride-sensitive sodium channel family, which are involved in sodium reabsorption F25D1.5 F25D1.5 Member of the alcohol/ribitol dehydrogenase-like protein family dehydrogenase; This gene encodes a protein predicted by Eisenberg and coworkers, with 68% accuracy, to be mitochondrial. F25D7.1 F25D7.1 Protein of unknown function, has moderate similarity to C. elegans R151.6 F25D7.2 F25D7.2 Protein of unknown function, has weak similarity to human Hs.146393 F25D7.3 F25D7.3 Protein containing five C2H2 type zinc finger domains, which bind nucleic acids, has low similarity to B-lymphocyte induced maturation protein 1 (human PRDM1), which represses beta-interferon gene expression and may function as a tumor suppressor Zinc finger, C2H2 type (5 domains) F25D7.4 F25D7.4 Protein of unknown function, has strong similarity to uncharacterized C. elegans C36A4.5 claustrin like F25D7.5 F25D7.5 Protein of unknown function, has low similarity to uncharacterized C. elegans Y70G10A.2 EGF-like domain F25E2.1 F25E2.1 Member of the rhodopsin family of G protein-coupled receptors (GPCR) F25E2.2 F25E2.2 Protein with moderate similarity to C. elegans B0280.7 gene product F25E2.3 F25E2.3 Member of the Acyl-CoA thioesterase family, which hydrolyze a range of acyl-CoA thioesters, has moderate similarity to peroxisomal acyl-CoA thioesterase 1 (human PTE1), which cleaves thioester bonds mostly on medium chain acyl CoAs acyl-CoA thioesterase F25E2.4 ifd-2;F25E2.4 Has similarity to intermediate filament proteins cytoplasmic intermediate filament; ifd-2 encodes a nonessential intermediate filament protein; IFD-2 is predicted to function as a structural component of the cytoskeleton; IFD-2 has no obvious function in RNAi assays. F25E2.5 daf-3;F25E2.5 Member of Smad family of signaling molecules that may act with DAF-4 receptor to transduce DAF-7-mediated neuroendocrine signals in tissues remodelled during dauer larva formation daf-3 encodes a Smad protein; DAF-3 functions as a transcriptional regulator that is required for formation of the alternative dauer larval stage; DAF-3 activity is antagonized by signaling through the DAF-7/TGF-beta pathway which promotes reproductive growth; in yeast two-hybrid studies, DAF-3 interacts with SMA-3, another Smad protein that does not appear to have a role in dauer formation; a DAF-3::GFP fusion protein is expressed in many tissues that undergo remodeling during dauer development; DAF-3 localizes predominantly to the cytoplasm, but is also found associated with chromosomes in mitotic cells. F25E5.1 F25E5.1 Protein of unknown function, has weak similarity to C. elegans Y48G1A_53.E F25E5.10 F25E5.10 Member of the trypsin family of serine proteases, has low similarity to uncharacterized C. elegans F25E5.4 F25E5.12 F25E5.12 Member of the 7-transmembrane chemoreceptor family of G protein-coupled receptors (GPCR), has weak similarity to C. elegans ODR-10, which is involved in odorant response 7TM chemoreceptor, str family F25E5.13 F25E5.13 Protein of unknown function, has strong similarity to C. elegans F49H6.4 7TM chemoreceptor, srh family F25E5.14 F25E5.14 Protein of unknown function, putative paralog of C. elegans F25E5.11 7TM chemoreceptor, srh family F25E5.2 F25E5.2 Protein of unknown function, has high similarity to uncharacterized C. elegans F01D5.10 F25E5.3 F25E5.3 Protein of unknown function, has low similarity to uncharacterized C. elegans F25E5.4 F25E5.4 F25E5.4 Member of the trypsin family of serine proteases, has low similarity to uncharacterized C. elegans F25E5.3 F25E5.5 F25E5.5 Member of an uncharacterized protein family This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins. F25E5.6 F25E5.6 Protein containing a nuclear hormone receptor C4-type zinc finger domain, which bind DNA and may be involved in regulation of transcription and a nuclear hormone receptor ligand-binding domain, has high similarity to uncharacterized C. elegans NHR-60 F25E5.7 F25E5.7 Putative ortholog of C. elegans F25E5.4 gene product F25E5.8 F25E5.8 Protein of unknown function F25E5.9 F25E5.9 Protein of unknown function F25F1.1 F25F1.1 Protein of unknown function F25F1.2 F25F1.2 Protein of unknown function, has weak similarity to a region of heavy polypeptide of neurofilament (mouse Nfh), which is a cytoskeletal structural protein that may regulate axonal caliber, synaptic transmission, and type IV intermediate filament assembly F25F2.1 F25F2.1 Protein containing a protein kinase domain, has low similarity to vaccinia related kinase 1 (mouse Vrk1), which is a nuclear serine-threonine protein kinase that undergoes autophosphorylation serine/threonine kinase F25F2.2 cdh-4;F25F2.2 Protein containing an extracellular laminin G domain, 23 cadherin domains, and three epidermal growth factor (EGF)-like domains, has a region of weak similarity to cadherin 23 (otocadherin, mouse Cdh23), which is involved in sensorineural hearing Approximately 25 cadherin-repeats, 3 EGF domains and one Laminin G domain; A homolog of a member of the cadherin superfamily that is involved in cell-cell adhesion. F25F6.1 F25F6.1 Protein of unknown function F25F8.1 F25F8.1 Protein of unknown function F25F8.2 F25F8.2 Avermectin-sensitive glutamate-gated chloride channel GluCl-beta subunit glutamate-gated chloride channel protein; glc-2 encodes the beta subunit of a glutamate-gated chloride channel; in vivo, GLC-2 is capable of forming homomeric glutamate-activated channels, as well as heteromeric channels with GLC-1 that can be activated by glutamate and avermectins, antihelmintics that inhibit pharyngeal pumping; as loss of glc-2 activity via large-scale RNAi screens does not result in any obvious abnormalities, the precise role of GLC-2 in development and/or behavior is not yet known; however, GLC-2 expression is generally restricted to the pm4 pharyngeal muscles of larvae and adults, suggesting a role for GLC-2 in regulation of glutamatergic inhibition of pharyngeal pumping. F25G6.1 F25G6.1 Protein of unknown function, has high similarity to uncharacterized C. elegans F57G4.2 F25G6.2 F25G6.2 Protein with low similarity to symplekin (human SPK), which is a tight junction plaque protein expressed in endothelial cells and may be involved in mRNA polyadenylation F25G6.3 acr-16;Ce21;F25G6.3 Nicotinic acetylcholine receptor alpha-1 subunit ligand-gated ion channel subunit; acr-16 encodes an alpha-7-like homomer-forming subunit of the nicotinic acetylcholine receptor (nAChR) superfamily orthologous to human nicotinic cholinergic receptor alpha 7 (CHRNA7; OMIM:118511; possibly associated with schizophrenia and juvenile myoclonic epilepsy); ACR-16 functions as a ligand-gated ion channel that probably regulates fast action of acetylcholine at neuromuscular junctions and in the nervous system; ACR-16 is active as a homomeric receptor, and responds robustly to acetylcholine when expressed in Xenopus oocytes; acr-16 is expressed in distal and proximal intestinal cells. F25G6.4 acr-15;F25G6.4 Protein containing neurotransmitter-gated ion-channel ligand binding and transmembrane domains, has moderate similarity to C. elegans ACR-16, which is a nicotinic acetylcholine receptor alpha-1 subunit ligand-gated ion channel subunit; A homolog of an alpha type nicotinic acetylcholine receptor subunit involved in the mediation of fast synaptic transmission at neuromuscular junctions. F25G6.5 F25G6.5 Member of a family of dehydrogenases dehydrogenase; This gene encodes a protein predicted by Eisenberg and coworkers, with 68% accuracy, to be mitochondrial. F25G6.6 F25G6.6 Member of the asparagine synthase family, contains two glutamine amidotransferases class II (purF-type) domains, has moderate similarity to asparagine synthase (human ASNS), which catalyzes the conversion of aspartate to asparagine asparagine synthetase; nrs-2 encodes a predicted asparaginyl-tRNA synthetase (AsnRS), a class II aminoacyl-tRNA synthetase that catalyzes the attachment of asparagine to its cognate tRNA and is thus required for protein biosynthesis; loss of nrs-2 function via RNA-mediated interference (RNAi) does not result in any obvious abnormalities. F25G6.7 F25G6.7 Member of the sugar (and other) transporter family, has low similarity to human SLC17A7, which is a brain-specific Na+-dependent inorganic phosphate cotransporter that localizes exclusively to neuron-rich regions sugar transporter F25G6.8 F25G6.8 Protein with high similarity to signal recognition particle 14 kDa (human SRP14), which is involved in translocation of synthesized proteins across the rough endoplasmic reticulum membrane, member of the signal recognition particle 14kD protein family F25G6.9 F25G6.9 Protein of unknown function F25H10.1 F25H10.1 Protein of unknown function F25H2.1 F25H2.1 Protein containing a C2 domain, which may be involved in calcium-dependent phospholipid binding and a CUE domain, has a region of moderate similarity to human TOLLIP, which mediates interleukin-1 receptor signaling C2 domain F25H2.10 F25H2.10 Protein with high similarity to ribosomal protein P0 (rat Arbp), which functions in polypeptide chain elongation during translation, member of the ribosomal L10 family, protein of the large 60S ribosomal subunit deoxyribonuclease; rpa-0 encodes an acidic ribosomal subunit protein P0. F25H2.11 F25H2.11 Member of the translationally controlled tumor protein family, has moderate similarity to human TPT1, which is histamine-releasing factor and cytokine that mediates inflammatory processes and is associated with Alzheimer Disease and Down Syndrome TCTP protein F25H2.12 F25H2.12 Protein of unknown function, has low similarity to uncharacterized human LOC51093 F25H2.13 F25H2.13 Protein with low similarity to S. cerevisiae Rad3p, which is a DNA helicase component of RNA polymerase II transcription initiation factor TFIIH (factor b) and of the nucleotide excision repairosome DEAH-type helicase F25H2.2 F25H2.2 Protein containing a phox protein (PX) domain, which bind phosphoinositides, and a PDZ, DHR, or GLGF domain, which are found in signaling proteins Phosphatase/kinase domain F25H2.3 F25H2.3 Protein containing two ankyrin (Ank) repeats, which may mediate protein-protein interactions Ank repeat F25H2.4 F25H2.4 Protein of unknown function, has low similarity to uncharacterized mouse 1500005A01Rik F25H2.5 F25H2.5 Protein with high similarity to nucleoside diphosphate kinase B (rat Nme2), which is involved in nucleoside metabolism and binds the asthma therapeutic drug cromoglycate, member of the nucleoside diphosphate kinase family nucleoside diphosphate kinase F25H2.6 F25H2.6 Protein containing a pleckstrin homology (PH) domain, and a START (Steroidogenic Acute Regulatory protein) domain, which binds lipids, has low similarity to collagen type IV alpha 3 binding protein (Goodpasture antigen-binding protein, human COL4A3BP) PH domain F25H2.7 F25H2.7 Protein of unknown function, has moderate similarity to uncharacterized C. elegans F31F4.1 glycosyltransferase F25H2.8 F25H2.8 Protein of unknown function F25H2.9 pas-5;F25H2.9 Protein with high similarity to proteasome subunit alpha type 5 (ZETA) (human PSMA5), which is a component of the 20S catalytic core proteasome that is involved in cellular protein degradation, member of the A- or B-type proteasome family proteasome zeta chain F25H5.1 F25H5.1 Protein containing eleven LIM domains, which may mediate protein-protein interactions, has a region of high similarity to four and a half LIM domains 2 (human FHL2), which may be involved in maintenance of terminally differentiated cardiac muscle LIM domain containing proteins (6 domains) F25H5.2 F25H5.2 Protein of unknown function F25H5.3 F25H5.3 Protein with high similarity to pyruvate kinase 3 (rat Pkm2), which converts phosphoenolpyruvate to pyruvate in glycolysis, contains two pyruvate kinase barrel (active) domains and two pyruvate kinase alpha or beta domains Pyruvate kinase F25H5.4 eft-2;F25H5.4 Protein with high similarity to translation elongation factor 2 (EF-2) (rat Eef2), which is involved in peptide elongation in protein biosynthesis, contains elongation factor Tu GTP binding and domain 2 domains and an elongation factor G C-terminal domain Elongation factor Tu family (contains ATP/GTP binding P-loop); eft-2 encodes a homolog of translation elongation factor 2 (EF-2), a GTP-binding protein essential for the elongation phase of protein synthesis; eft-2 is required for embryogenesis and vulval morphogenesis, and is expressed during all stages of development, including the dauer larval stage. F25H5.5 F25H5.5 Protein of unknown function, has weak similarity to C. elegans W06A7.3 F25H5.6 F25H5.6 Similar to a protein of the large ribosomal subunit from human and S. cerevisiae F25H5.7 F25H5.7 Member of the protein-tyrosine phosphatase family, which are involved in control of cell growth, proliferation, differentiation and transformation, has low similarity to mouse Ptpn20, which is a non-receptor type protein tyrosine phosphatase Protein-tyrosine phosphatase F25H5.8 F25H5.8 Protein of unknown function, has weak similarity to C. elegans R10D12.6 F25H8.1 F25H8.1 Protein of unknown function, has low similarity to uncharacterized S. pombe Spac6b12.09p Yeast protein 00926 like F25H8.2 F25H8.2 Protein of unknown function F25H8.3 gon-1;F25H8.3 Metalloprotease required for gonad morphogenesis thrombospondin like; gon-1 encodes a functional metalloprotease that defines a new sub-family of secreted proteases known as MPT (metalloprotease with thrombospondin type 1 repeats); the other two members of this family are the bovine procollagen I N-protease ( PINP ) and the murine enzyme ADAMTS-1; gon-1 is essential for hermaphrodite gonadal morphogenesis; sequence homology with other metalloproteases suggests that it functions by remodelling the extracellular matrix; GON-1 is expressed at high levels within the gonadal distal tip cell during migration. F25H8.5 dur-1;dur135;F25H8.5 Protein containing eleven late embryogenesis abundant (LEA) protein domains, which are found in proteins expressed under conditions of dehydration stress The dur-1 ('Dauer UpRegulated') gene encodes proteins (DUR-1A and DUR-1C) that are predicted to be hydrophilic and heat-resistant, and that might participate in anhydrobiosis; expression of at least one dur-1 transcript is upregulated in dauer larvae and other transcripts may be specifically expressed in dauer larvae. F25H8.6 F25H8.6 Protein containing a BED zinc finger domain F25H8.7 spe-29;F25H8.7 Spermiogenesis protein spermatogenesis protein (spe-29) F25H9.1 F25H9.1 Protein of unknown function, putative paralog of C. elegans F25H9.3 Activin types I and II receptor domain F25H9.2 F25H9.2 Protein containing a BTB (BR-C, ttk and babor) or POZ (Pox virus and zinc finger) domain, which are found in some DNA and actin binding proteins and may mediate protein-protein interactions, has weak similarity to uncharacterized C. elegans Y75B12B.4 F25H9.3 F25H9.3 Protein containing an activin type I or II receptor domain, has high similarity to uncharacterized C. elegans F25H9.1 F25H9.4 F25H9.4 Protein containing a meprin and TRAF homology (MATH) domain, has low similarity to uncharacterized C. elegans Y75B12B.4 F25H9.5 F25H9.5 Protein of unknown function frm-10 encodes a protein that contains an N-terminal FERM (Band 4.1-ezrin-radixin-moesin) domain; by homology, FRM-10 is predicted to function as a membrane-cytoskeleton linker protein that plays a role in cell adhesion, migration, or organization of cell surface structures; however, as loss of frm-10 activity via large-scale RNAi screens does not result in any obvious abnormalities, the precise role of FRM-10 in C. elegans development and/or behavior is not yet known. F25H9.6 F25H9.6 Protein with strong similarity to S. cerevisiae Sis2p, a protein involved in ion homeostasis Yeast hypothetical 65.2 KD protein like F25H9.7 F25H9.7 Protein of unknown function, has moderate similarity to uncharacterized human DC11 F25H9.8 Y2H9A.4;Y2H9.C;F25H9.8 Protein with strong similarity to C. elegans ZC196.5 gene product F26A1.1 F26A1.1 Protein of unknown function F26A1.10 F26A1.10 Protein of unknown function F26A1.11 F26A1.11 Protein containing a C-type lectin domain, which mediate calcium-dependent carbohydrate recognition, has moderate similarity to uncharacterized C. elegans F26A1.12 F26A1.12 F26A1.12 Protein containing a C-type lectin domain, which mediate calcium-dependent carbohydrate recognition, has moderate similarity to uncharacterized C. elegans F26A1.11 F26A1.13 F26A1.13 Protein of unknown function F26A1.14 F26A1.14 Protein with similarity to vertebrate 2',3'-cyclic nucleotide 3'-phosphodiesterases, has weak similarity across the middle region to human BRCA2 (Hs.23518) 2',3'-cyclic nucleotide 3'-phosphodiesterase F26A1.2 F26A1.2 Protein containing a fork head domain, which are found in transcription factors involved in cell fate determination, has moderate similarity to uncharacterized C. elegans C29F7.4 fkh-5 encodes a member of the forkhead domain transcription factor family. F26A1.3 F26A1.3 Protein containing a protein kinase domain, has low similarity to uncharacterized C. elegans F25F2.1 Protein kinase F26A1.4 F26A1.4 Protein containing a protein kinase domain, has a region of low similarity to a region of C. elegans KIN-19, which is a putative casein kinase 1 that appears to regulate polarity of the EMS blastomere Casein kinase F26A1.6 F26A1.6 Putative ortholog of C. elegans F26A1.8 gene product F26A1.7 F26A1.7 Protein of unknown function, has strong similarity to C. elegans F26A1.8 F26A1.8 F26A1.8 Member of the amine oxidase protein family Amine oxidase F26A1.9 F26A1.9 Protein of unknown function F26A10.1 F26A10.1 Protein of unknown function F26A10.2 F26A10.2 Putative zinc-finger protein Zinc finger; F26A10.2 encodes a protein with four zinc-finger domains and a glutamine/asparagine-rich domain, that is required for maintenance of the germline and for locomotion; F26A10.2(RNAi) animals are uncoordinated and have sterile progeny. F26A3.1 F26A3.1 Protein of unknown function, has low similarity to uncharacterized human FLJ21820 F26A3.2 F26A3.2 Protein with strong similarity to S. cerevisiae Mud13p, the small subunit of nuclear cap-binding protein complex Cap binding protein F26A3.3 ego-1;F26A3.3 Putative member of the PTGS (post-transcriptional gene silencing) RdRP (RNA-directed RNA polymerase) gene family that is necessary for germ-line development The ego-1 gene encodes a homolog of RNA-directed RNA polymerase that is essential for germ-line development. F26A3.4 F26A3.4 Protein containing a dual specificity phosphatase catalytic domain, has a region of low similarity to a region of human MKP-7, which is a cytoplasmic protein phosphatase that inactivates JNK/SAPK and p38 mitogen-activated protein kinase family members protein-tyrosine phosphatase F26A3.5 F26A3.5 Protein with weak similarity to C. elegans C29F5.2 gene product F26A3.6 F26A3.6 Protein of unknown function F26A3.7 F26A3.7 Protein of unknown function F26A3.8 F26A3.8 Putative ortholog of C. elegans rrf-3 gene product rrf-1 encodes an RNA-directed RNA polymerase (RdRP) homolog required for somatic (but not germline) RNAi; RRF-1 is also required for 'transitive interference'. F26B1.1 F26B1.1 Protein with strong similarity to C. elegans C48E7.7 gene product F26B1.2 F26B1.2 Protein containing three KH domains, which may bind RNA, has moderate similarity to heterogeneous nuclear ribonucleoprotein K (mouse Hnrpk), which is a transcription factor that binds the kappa B enhancer RNA-binding protein F26B1.3 ima-2;F26B1.3;1G893 Member of the karyopherin-alpha protein family expressed in germ line tissue importin alpha, nuclear transport factor F26B1.4 F26B1.4 Protein containing two collagen triple helix repeats and a nematode cuticle collagen N-terminal domain, has a region of high similarity to a region of C. elegans BLI-1, which is a likely collagen involved in embryogenesis and morphogenesis and chemotaxis F26B1.5 F26B1.5 Member of the serine or threonine protein phosphatase family, has moderate similarity to C. elegans ZC477.2, which is involved in embryogenesis or morphogenesis serine/threonine protein phosphatase F26B1.6 F26B1.6 Member of the C. elegans Srg family of integral membrane proteins, which may be involved in chemosensation, has high similarity to uncharacterized C. elegans SRG-11 7TM chemoreceptor, srg family F26B1.7 F26B1.7 Protein containing a fork head domain, which are found in transcription factors involved in cell fate determination, has a region of high similarity to a region of mouse Foxf1a, which is a transcriptional activator required for mesoderm differentiation fork-head domain-type transcription factors; let-381 encodes a forkhead transcription factor and was identified in a screen for essential genes; let-381 is essential for development at different times as mutants exhibit embryonic and early larval lethality, with a few developing to sterile adults; inactivation of let-381 using RNA interference results in adults with mesodermal cell lineage defects and a reduced number of coelomocytes; reporter-gene assays indicate LET-318 is expressed when the embryo starts to elongate and continues to be expressed through all larval stages and into the adult. F26C11.1 F26C11.1 Member of the histidine acid phosphatase family, which hydrolyze phosphate esters at low pH, has a region of low similarity to human ACPP, which is a prostatic acid phosphatase that dephosphorylates the oncoprotein ERBB2 and regulates cell growth acid phosphatase F26C11.2 unc-4;ceh-4;F26C11.2 Homeodomain transcription factor involved in neuronal development, has similarity over the homeodomain to many human and D. melanogaster homeodomain transcription factors homeobox protein (otd subfamily); The unc-4 gene encodes a paired-class homeodomain protein with homologs in Drosophila and vertebrates; UNC-4 is required for establishing the identity of the A class motor neurons DA and VA, and is thus required for movement, axon guidance, and synapse formation; UNC-4 is negatively regulated by VAB-7, and UNC-4 activity requires UNC-37. F26C11.3 F26C11.3 Protein containing a sushi or short consensus repeat (SCR) domain, which are found in complement and adhesion proteins, has low similarity to uncharacterized C. elegans F59A6.3 Sushi domain F26D10.10 F26D10.10 Protein with high similarity to glutamine synthase (rat Glul), which catalyzes the condensation of glutamate and ammonia to form glutamine and may clear L-glutamate from neuronal synapses, contains one glutamine synthetase domain Carbamoyl-phosphate synthase (CPSase) (2 domains), Biotin-requiring enzymes F26D10.11 F26D10.11 Protein of unknown function F26D10.12 F26D10.12 Protein containing a C-type lectin domain, which mediate calcium-dependent carbohydrate recognition Lectin C-type domain F26D10.3 hsp-70;hsp-1;F26D10.3 Member of the heat shock HSP70 protein family HSP-1 heat shock 70kd protein A; hsp-1 encodes hsp70A, a member of the heat shock family of proteins; hsp70A is closely related to the Drosophila heat inducible hsp70s and the S. cerevisiae SSA hsp70 subfamily; the hsp-1 gene is normally expressed throughout development and upon heat-shock the hsp-1 mRNA is enhanced 2-6 fold; down-regualtion of hsp-1 via RNA interference results in a small reduction in the life-span of an age-1 mutant indicating that hsp-1 may play some role in regulating longevity. F26D10.8 F26D10.8 Member of the 7-transmembrane chemoreceptor family of G protein-coupled receptors (GPCR), has high similarity to uncharacterized C. elegans F40F9.4 F26D10.9 F26D10.9 Protein containing one alpha amylase N-terminal catalytic domain, which degrade starches, has low similarity to neutral and basic amino acid transporter (human SLC3A1), which is a cystine transporter associated with cystinuria type I and kidney stones Sugar (and other) transporters F26D11.1 F26D11.1 Protein of unknown function, has a region of low similarity to glucokinase (gluconate kinase, S. pombe Gnkp) gluconokinase F26D11.10 F26D11.10 Member of the integral membrane innexin family, which are involved in the formation of gap junctions, has moderate similarity to C. elegans UNC-7, which is required in motor neurons for coordinated locomotion F26D11.11 let-413;F26D11.11 Member of the leucine-rich repeat (LRR) protein family; plays a critical role in the process of organizing and positioning adherens junctions let-413 encodes a protein with strong similarity to human ERBIN, rat DENSIN, Drosophila SCRIB and its human ortholog hSCRIB; LET-413 protein is localized to the basolateral region of epithelial cells, and is required for the assembly of adherens junctions. F26D11.2 F26D11.2 Protein of unknown function F26D11.3 F26D11.3 Protein with strong similarity to C. elegans C43E11.7 gene product F26D11.4 F26D11.4 Protein of unknown function, has weak similarity to C. elegans F26D11.9 F26D11.5 F26D11.5 Protein of unknown function, has moderate similarity to C. elegans F26D11.9 F26D11.6 F26D11.6 Protein with weak similarity to H. sapiens GOLGA1 (golgi autoantigen, golgin subfamily a, 1) F26D11.9 F26D11.9 Protein of unknown function, has moderate similarity to C. elegans F26D11.5 F26D12.A F26D12.2;F26D12.A Protein of unknown function F26D2.1 F26D2.1 Member of the 7-transmembrane chemoreceptor family of G protein-coupled receptors (GPCR), has high similarity to uncharacterized C. elegans T23F1.3 F26D2.10 F26D2.10 Protein containing a WSN domain of unknown function, an ankyrin (Ank) repeat, which may mediate protein-protein interactions, and a BRCA1 (breast cancer type 1) C terminus (BRCT) domain, has high similarity to uncharacterized C. elegans F36D3.5 Ank repeat, BRCA1 C Terminus (BRCT) domain F26D2.11 F26D2.11 Protein of unknown function, has high similarity to uncharacterized C. elegans K03D7.2, which is predicted to be a G protein-coupled receptor 7TM chemoreceptor, srw family F26D2.12 F26D2.12 Member of the C-type lectin family, has weak similarity to human pancreatitis-associated secreted protein PAP Lectin C-type domain F26D2.13 F26D2.13 Member of an uncharacterized protein family F26D2.14 F26D2.14 Member of an uncharacterized protein family F26D2.15 F26D2.15 Member of the short-chain dehydrogenase-reductase family, which are NAD- or NADP-dependent oxidoreductases, has low similarity to human HSA250303, which is a peroxisomal trans 2-enoyl CoA reductase that catalyzes the reduction of trans 2-enoyl CoAs Alcohol/other dehydrogenases, short chain type; This gene encodes a protein predicted by Eisenberg and coworkers, with 68% accuracy, to be mitochondrial. F26D2.2 F26D2.2 Putative coiled-coil protein, has weak similarity to human Golgi autoantigens F26D2.3 F26D2.3 Member of the core-2 or I-branching enzyme family, has low similarity to core 2 beta-1,6-N-acetylglucosaminyltransferase-leukocyte type (human GCNT1), which forms O-glycan structures and is associated with Wiskott-Aldrich syndrome and multiple sclerosis F26D2.4 F26D2.4 Member of the 7-transmembrane chemoreceptor family of G protein-coupled receptors (GPCR), has strong similarity to uncharacterized C. elegans F26D2.5 F26D2.5 F26D2.5 Member of the 7-transmembrane chemoreceptor family of G protein-coupled receptors (GPCR), has strong similarity to uncharacterized C. elegans F26D2.4 F26D2.7 F26D2.7 Member of the 7-transmembrane chemoreceptor family of G protein-coupled receptors (GPCR), has low similarity to C. elegans ODR-10, which is involved in odorant response F26D2.9 F26D2.9 G protein-coupled receptor of unknown function, no homolog found in human or D. melanogaster 7TM chemoreceptor, srw family F26E4.1 sur-6;PP2A-B;F26E4.1 Probably the regulatory subunit of PP2A in C. elegans protein phosphatase F26E4.10 Ce-Drosha;F26E4.10 Member of the RNase III domain protein family, but contains two RNase III signature motifs drsh-1 encodes a predicted RNase III-type ribonuclease that is orthologous to Drosophila and human Drosha; by homology, DRSH-1 is predicted to function as an endoribonuclease that, in the nucleus, initiates cleavage of primary miRNA transcripts (pri-mRNAs) into pre-miRNAs that are then exported to the cytoplasm for further processing; loss of drsh-1 activity via RNAi results in re-expression of a let-7-silenced reporter in adults, suggesting that DRSH-1 is required for let-7 processing; in addition, DRSH-1 also appears to be required for fertility, as adults lacking drsh-1 activity are sterile; along with PASH-1, a double-stranded RNA binding protein, DRSH-1 may be part of a conserved multiprotein complex that regulates nuclear pri-miRNA splicing. F26E4.11 F26E4.11 Protein with similarity to H. sapiens AMFR (autocrine motility factor receptor) Zinc finger, C3HC4 type (RING finger) F26E4.12 F26E4.12 Protein with high similarity to glutathione peroxidase 4 (phospholipid hydroperoxide glutathione peroxidase, human GPX4), which is an antioxidant selenoprotein that protects cells from hydroperoxide injury, member of the glutathione peroxidase family glutathione peroxidase F26E4.2 F26E4.2 Protein of unknown function F26E4.3 F26E4.3 Member of the papain family of cysteine proteases, has moderate similarity to tubulointerstitial nephritis antigen (human TINAG), which is a basement membrane protein that regulates renal tubulogenesis and is associated with tubulointerstitial disorders cysteine protease F26E4.4 F26E4.4 Protein of unknown function F26E4.5 F26E4.5 Protein containing one protein kinase domain and one Src homology 2 (SH2) domain, which are regulatory modules of intracellular signaling, has moderate similarity to fer (fps/fes related) tyrosine kinase (mouse Fert2), which is involved in male meiosis Src homology domain 2, tyrosine-protein kinase (FES/FPS subfamily) F26E4.6 F26E4.6 Member of the cytochrome c oxidase subunit VIIc family, which are part of the terminal oxidase in the mitochondrial electron transport chain cytochrome C oxidase F26E4.7 F26E4.7 Protein containing an extracellular fasciclin domain, has a region of low similarity to a region of osteoblast specific factor 2 (periostin, mouse Osf-2), which is a putative cell adhesion molecule involved in heart valve development and bone formation fasciclin; The F26E4.7 gene encodes a homolog of human BIGH3, which when mutated leads to Groenouw granular dystrophy, type 1 (OMIM:122200). F26E4.8 tba-1;alpha-1;F26E4.8 Alpha tubulin specific to meiotic spindles and mitotic spindles of neurons TBA-2 tubulin alpha-2 chain F26E4.9 F26E4.9 Member of the cytochrome c oxidase subunit Vb family, has moderate similarity to cytochrome c oxidase subunit 5b (mouse Cox5b), which is a subunit of cytochrome c oxidase involved in electron transport cytochrome C oxidase F26F12.1 F26F12.1 Protein containing two collagen triple helix repeats and one nematode cuticle collagen N-terminal domain, has moderate similarity to a region of C. elegans BLI-1, which is a putative collagen involved in embryogenesis and morphogenesis and chemotaxis cuticular collagen F26F12.2 F26F12.2 Protein of unknown function, has weak similarity to C. elegans F37A8.2 F26F12.3 F26F12.3 Protein of unknown function, has weak similarity to uncharacterized C. elegans Y58A7A.4 F26F12.4 F26F12.4 Protein of unknown function, has weak similarity to C. elegans F59B10.3 F26F12.5 F26F12.5 Protein of unknown function F26F12.6 F26F12.6 Member of the 7-transmembrane chemoreceptor family of G protein-coupled receptors (GPCR), has moderate similarity to uncharacterized C. elegans C04F2.1 7TM chemoreceptor, srh family F26F12.7 let-418;chd-4;evl-11;F26F12.7 Putative chromodomain helicase DNA-binding protein, affects embryonic and vulval development DNA helicase; The let-418 gene encodes a homolog of Mi-2/CHD3, a component of the nucleosome remodeling and histone deacetylase (NURD) complex; LET-418 is similar to DNA helicases, homologous to human AIRE (OMIM:607358, mutated in autoimmune polyendocrinopathy syndrome), and paralogous to CHD-3; with MEP-1, LET-418 is required to repress germline-specific genes in somatic cells, and also negatively regulates RAS-dependent postembryonic vulval development (via the synMuvB pathway); LET-418 and CHD-3 are redundantly required for specification of secondary cell fates in vulval development; LET-418 is expressed in all interphase nuclei throughout development; LET-418 is bound by MEP-1, and also interacts with HDA-1 and PIE-1; these interactions probably reflect repression of LET-418 by PIE-1 in the germline. F26F2.1 F26F2.1 Protein of unknown function F26F2.2 F26F2.2 Protein with strong similarity to C. elegans F26F2.4 gene product F26F2.3 F26F2.3 Protein of unknown function F26F2.4 F26F2.4 Member of an uncharacterized protein family F26F2.5 F26F2.5 Protein of unknown function, has high similarity to uncharacterized C. elegans F26F2.4 F26F2.6 F26F2.6 Protein containing a C-type lectin domain, which mediate calcium-dependent carbohydrate recognition F26F2.7 F26F2.7 Protein of unknown function F26F4.1 F26F4.1 Protein of unknown function, has low similarity to uncharacterized human LOC51608 F26F4.10 F26F4.10 Protein with high similarity to human RARS, which is an arginyl-tRNA synthetase that aminoacylates its cognate tRNAs with arginine for protein biosynthesis, member of the class I arginyl (R) tRNA synthetase family arginyl tRNA synthetase F26F4.11 F26F4.11 Putative RNA polymerase II subunit, putative ortholog of Human Hs.3128 protein, an RNA polymerase II subunit F26F4.12 F26F4.12 Protein with moderate similarity to C. elegans mel-11 gene product F26F4.2 F26F4.2 Protein of unknown function, putative paralog of C. elegans F37A8.1 spt-2 encodes a novel protein with high similarity to C. elegans F37A8.1 and C. briggsae CBG18186. F26F4.3 F26F4.3 Member of the rhomboid family of integral membrane proteins F26F4.4 F26F4.4 Protein containing a START (Steroidogenic Acute Regulatory protein) domain, which is a lipid-binding domain in StAR, HD-ZIP and signalling proteins, has low similarity to uncharacterized human MLN64, which may function in steroidogenesis F26F4.5 F26F4.5 Protein of unknown function F26F4.6 F26F4.6 Protein of unknown function F26F4.7 F26F4.7 Member of the B-box zinc finger family, contains a C3HC4 type (RING) zinc finger, which may mediate protein-protein interactions, and four NHL repeats, has weak similarity to C. elegans NCL-1, which is a B-box zinc finger that represses RNA polymerases F26F4.8 F26F4.8 Protein with a probable zinc finger domain F26F4.9 F26F4.9 Protein containing an N-terminal coiled-coil domain and three C-terminal ankyrin repeat domains ankyrin and desmoplakin repeat regions F26G1.1 F26G1.1 Protein of unknown function F26G1.2 F26G1.2 Protein of unknown function F26G1.3 F26G1.3 Member of the transthyretin-like family, has moderate similarity to uncharacterized C. elegans C27D9.2 F26G1.4 F26G1.4 Protein of unknown function F26G1.5 F26G1.5 Protein containing a DB module domain F26G1.6 F26G1.6 Member of the M13 peptidase family of zinc metalloproteases, has low similarity to endothelin-converting enzyme 1 (rat Rn.7000), which is a membrane-bound zinc metalloprotease that generates the endothelin vasoconstrictors Neprilysin; F26G1.6 encodes a neprilysin; neprilysins are thermolysin-like zinc metallopeptidases, found on the outer surface of animal cells, that negatively regulate small signalling peptides (e.g., enkephalin, tachykinin, insulin, and natriuretic peptides) by cleaving them; while F26G1.6 has no clear orthologs in other organisms, it falls into a group of proteins that includes the classical neprilysins found in mammals (e.g., PEX [OMIM:307800] and the enkephalin cleaving enzymes). F26G1.7 msp-3;F26G1.7 Member of the major sperm-specific protein (MSP) family Major sperm protein; msp-3 encodes a protein that belongs to a family of proteins called the Major Sperm Proteins (MSPs) that is conserved in nematodes; msp-3 is similar in nucleotide sequence to the msp genes from the nematode Onchocerca volvulus; the msp gene family consists of closely related, small, basic proteins that make up 15% of sperm protein; this multigene family consists of over fifty genes, including many pseudogenes; MSPs are involved in both extracellular signaling and cytoskeletal functions during reproduction-MSP antagonizes Eph/ephrin signaling, in part, by binding VAB-1 Eph receptor tyrosine kinase on oocytes and sheath cells to promote oocyte maturation and MAPK activation; MSP proteins assemble into fibrous networks that drive movement of the C. elegans sperm; msp genes are expressed only in late primary spermatocytes. F26G5.1 F26G5.1 Protein of unknown function F26G5.10 F26G5.10 Putative G protein-coupled receptor, no homolog found in human or D. melanogaster 7TM chemoreceptor, srsx family F26G5.2 F26G5.2 Member of the 7-transmembrane chemoreceptor family of G protein-coupled receptors (GPCR), has low similarity to C. elegans ODR-10, which is involved in odorant response 7TM chemoreceptor, str family F26G5.4 F26G5.4 Member of the 7-transmembrane chemoreceptor family of G protein-coupled receptors (GPCR), has high similarity to uncharacterized C. elegans F26G5.5 7TM chemoreceptor, str family F26G5.5 F26G5.5 Member of the 7-transmembrane chemoreceptor family of G protein-coupled receptors (GPCR), has low similarity to C. elegans ODR-10, which is involved in odorant response 7TM chemoreceptor, str family F26G5.8 F26G5.8 Protein with moderate similarity to C. elegans Y67D2.2 gene product F26G5.9 tam-1;F26G5.9 Protein which ontains RING finger and B-box zinc finger motifs, shares the traits of the class-B synthetic multivulva (synMuv) alleles in C. elegans, and silences the expression of repetitive tandem arrays, a property of several synMuv genes tested tam-1 encodes a broadly expressed nuclear protein with RING finger, B-box, and glutamine/asparagine-rich domains that promotes signalling in the class B synthetic-multivulva gene pathway (which includes the lin-35/RB gene), and also promotes the activity of genes in multicopy transgenic arrays; the normal role of TAM-1's class B activity is presumably to inhibit RAS pathway activity in vulval development, while TAM-1's effect on transgenes may be through changes in the acetylation state of histones in chromatin. F26H11.1 F26H11.1 Protein of unknown function, has very strong similarity to uncharacterized C. elegans 2O676 F26H11.2 F26H11.2 Member of the DDT domain family, which may bind DNA, contains two PHD-fingers and two AT-hook motifs, has a region of low similarity to a region of fetal Alzheimer antigen (fetal Alz-50 clone 1, human FALZ), which is a transcriptional repressor Bromodomain F26H11.3 F26H11.3 Bromodomain protein F26H11.4 F26H11.4 Protein with strong similarity to C. elegans M117.4 gene product F26H11.5 F26H11.5 Protein with weak similarity to chloride intracellular channel 4 (rat Clic4), which is a chloride transporter that may participate in regulating intracellular pH and trafficking of channel-containing vesicles and play a role in neuropeptide biogenesis F26H9.1 F26H9.1 Protein of unknown function F26H9.2 F26H9.2 Protein containing two RPEL repeats, which may be DNA binding elements, has low similarity to uncharacterized human H17739 F26H9.3 F26H9.3 Member of the transposase protein family transposase F26H9.4 F26H9.4 Member of the cytidylyltransferase family, has low similarity to nicotinamide mononucleotide (NMN) adenylyltransferase (human NMNAT), which acts in the transfer of the adenylyl moiety of ATP to NMN in both de novo and salvage pathways for NAD biosynthesis Yeast hypothetical protein YG15 like F26H9.5 F26H9.5 Member of the aminotransferases class-V family of pyridoxal-phosphate-dependent enzymes, has moderate similarity to S. cerevisiae Ser1p, which is a 3-phosphoserine transaminase that is involved in synthesis of serine from 3-phosphoglycerate phosphoserine aminotransferase F26H9.6 Ce-rab5;F26H9.6 Protein with high similarity to ras-related GTP-binding protein 5 (rat Rab5a), which regulates endocytic transport, member of the Ras superfamily of GTP-binding proteins RAS-related protein; rab-5 encodes a rab related protein of the Ras GTPase superfamily that affects both the localization of P-granules and of PAR-2, and also affects embryonic and larval viability and the cytoplasmic appearance of cells in the early embryo. F26H9.7 F26H9.7 Putative ubiquitin-conjugating (E2) enzyme ubiquitin-conjugating enzyme; uev-3 encodes a ubiquitin-conjugating enzyme (UBC or E2) variant that contains the UBC motif, but lacks the critical active-site cysteine residue necessary for catalytic activity; as loss of UEV-3 function via RNA-mediated interference (RNAi) does not result in any abnormalities, the precise role of UEV-3 in C. elegans development and/or behavior is not yet known; based on similarity to Saccharomyces cerevisiae and human proteins, however, UEV-3 may play a role in cell cycle control or response to stress or DNA damage. F26H9.8 F26H9.8 Predicted paralog of C. elegans F48E3.3, has strong similarity to human HUG1, UDP-glucose:glycoprotein glucosyltransferase UDP-glucose:glycoprotein glucosyltransferase like F27B3.2 F27B3.2 Putative ortholog of D. melanogaster nAcRalpha-96Ab (nicotinic Acetylcholine Receptor alpha 96Ab) channel protein; acr-21 encodes an alpha subunit of nicotinic acetylcholine receptor (nAChR); ACR-21 is a highly divergent member of the 'ACR-16' class of nAChR subunits, which includes ACR-7, ACR-9, ACR-10, ACR-11, ACR-14, ACR-15, ACR-16, and ACR-19, and is most closely related to the alpha-7 subunits of vertebrate nAChRs. F27B3.4 F27B3.4 Putative paralog of C. elegans Y95B8A.3 transposase F27B3.5 F27B3.5 Protein of unknown function, putative paralog of C. elegans C09E7.B F27B3.6 F27B3.6 Protein with weak similarity to C. elegans C09E7.2 gene product F27B3.7 F27B3.7 Protein with strong similarity to C. elegans C09E7.7 gene product F27C1.1 F27C1.1 Protein of unknown function, has moderate similarity to uncharacterized C. elegans F32B6.5 F27C1.10 F27C1.10 Protein of unknown function F27C1.11 F27C1.11 Protein containing a PLAT (Polycystin-1, Lipoxygenase, Alpha-Toxin) or LH2 (Lipoxygenase homology) domain, which may function in protein binding, and an IQ calmodulin-binding domain F27C1.12 F27C1.12 Protein of unknown function F27C1.13 F27C1.13 Protein of unknown function F27C1.2 F27C1.2;xem1-2 Protein with moderate similarity to C. elegans F31E8.4 gene product F27C1.3 F27C1.3 Protein containing a DUF236 domain of unknown function, has high similarity to uncharacterized C. elegans R08A2.1 F27C1.4 F27C1.4 Protein of unknown function F27C1.6 F27C1.6 Protein of unknown function, has low similarity to uncharacterized human KIAA0266 F27C1.7 F27C1.7 Member of the ATP synthase delta (OSCP) subunit family, has moderate similarity to ATP synthase H+ transporting mitochondrial F1 complex O subunit (oligomycin sensitivity conferring protein) (rat Rn.1817), which is a part of the F1F0-ATP synthase stalk ATPase; This gene encodes a protein predicted by Eisenberg and coworkers, with 68% accuracy, to be mitochondrial. F27C1.8 F27C1.8 Protein containing two collagen triple helix repeats and one nematode cuticle collagen N-terminal domain, has moderate similarity to a region of C. elegans BLI-1, which is a putative collagen involved in embryogenesis and morphogenesis and chemotaxis cuticular collagen; dpy-5 encodes a cuticle collagen that affects body length and cuticle structure and specifically affects the formation of annuli and the expression of dpy-7, dpy-13, and col-19; mRNA abundance increases two hours prior to the secretion of each new cuticle, and mRNA levels appear to increase at and after the L2 larval stages. F27C1.9 F27C1.9 Protein of unknown function F27C8.1 F27C8.1 Member of the amino acid permease family, putative ortholog of human cationic amino acid transporters SLC7A6, SLC7A7, and y+LAT1 integral membrane protein E16 like; aat-1 encodes a homolog of the human gene SLC7A5 (OMIM:600182). F27C8.2 F27C8.2 Protein of unknown function F27C8.3 F27C8.3 Protein of unknown function F27C8.4 F27C8.4 Protein of unknown function F27C8.5 F27C8.5 Protein containing a BTB (BR-C, ttk and babor) or POZ (Pox virus and zinc finger) domain, which are found in some DNA and actin binding proteins and may mediate protein-protein interactions BTB (also known as BR-C/Ttk) domain. F27C8.6 F27C8.6 Protein with low similarity to arylacetamide deacetylase (human AADAC), which is an esterase involved in the metabolic activation of arylamine carcinogens esterase F27D4.1 F27D4.1 Member of the electron transfer flavoprotein (ETF) alpha subunit family, which form heterodimers with ETF-beta subunits, has high similarity to uncharacterized electron transfer flavoprotein alpha subunit (human ETFA), which is linked to glutaricaciduria electron transfer flavoprotein alpha-subunit; The F27D4.1 gene encodes an ortholog of the human gene ELECTRON-TRANSFER-FLAVOPROTEIN, ALPHA POLYPEPTIDE (ETFA), which when mutated leads to glutaricaciduria type IIA (OMIM:231680). F27D4.2 F27D4.2 Protein of unknown function F27D4.4 F27D4.4 Protein containing a CCCH-type zinc finger domain, which bind DNA or RNA, has moderate similarity to uncharacterized human HT010 Yeast hypothetical protein YOR316OW like F27D4.5 F27D4.5 Protein with high similarity to branched chain alpha keto acid dehydrogenase E1 beta subunit (human BCKDHB), which is associated with maple syrup urine disease, contains transketolase C-terminal and pyridine binding domains 2-oxoisovalerate dehydrogenase; tag-173/F27D4.5 is orthologous to the human gene BRANCHED CHAIN KETO ACID DEHYDROGENASE E1, ALPHA POLYPEPTIDE (BCKDHB; OMIM:248600), which when mutated leads to maple syrup urine disease, type 1a; F27D4.5 protein is predicted to be mitochondrial. F27D4.6 F27D4.6 Protein of unknown function zinc-finger protein F27D9.1 unc-18;unc-19;lan-2;F27D9.1 Member of the Sec1p/vacuolar sorting protein family Acetylcholine regulator unc-18; unc-18 encodes an ortholog of S. F27D9.2 F27D9.2 Member of the sugar (and other) transport family, has low similarity to uncharacterized C. elegans F57A8.7 F27D9.3 F27D9.3 Protein of unknown function F27D9.4 F27D9.4 Protein of unknown function F27D9.5 F27D9.5 Protein containing carbamoyl-phosphate synthase L chain ATP binding and N-terminal domains, a biotin carboxylase C-terminal domain, and a biotin or lipoyl attachment domain, has moderate similarity to human MCCC1, which is involved in leucine catabolism Propionyl-coA carboxylase alpha chain precursor; The F27D9.5 gene encodes an ortholog of the human gene PROPIONYL-COA CARBOXYLASE ALPHA SUBUNIT (PCCA), which when mutated leads to propionicaciduria, type I (OMIM:232000). F27D9.6 F27D9.6 Member of the short-chain dehydrogenase-reductase family, which are NAD- or NADP-dependent oxidoreductases, has a region of low similarity to human SDR1, which is a short-chain dehydrogenase-reductase F27D9.7 F27D9.7 Member of the reprolysin (M12B) zinc metalloprotease family, which are also called adamalysins Alcohol dehydrogenase F27D9.8 F27D9.8 Protein containing two PDZ, DHR, or GLGF domains, which are found in signaling proteins, has low similarity to syntrophin gamma 2 (human SNTG2), which may play a role in signal transduction in neurons and is associated with Duchenne muscular dystrophy synapse-associated protein F27E11.1 CNT1;F27E11.1 Protein with high similarity to C. elegans CNT, which is a proton-dependent purine and pyrimidine, but not cytidine, nucleoside transporter, member of the Na+ dependent nucleoside transporter family of membrane transporters nucleoside transporter F27E11.2 CNT;ceCNT3;F27E11.2 Putative ortholog of Human SLC28A2 protein, a proton-dependent purine and pyrimidine, but not cytidine, nucleoside transporter nucleoside transporter F27E11.3 Cfz2;F27E11.3 Member of the Frizzled protein family, which are involved in establishment of embryonic polarity, contains two Frizzled (FZ, CRD) domains, has moderate similarity to human FZD5, which acts as a receptor for human WNT5A and mediates axis determination transmembrane receptor; cfz-2 encodes a member of the Frizzled family of membrane receptors. F27E5.1 F27E5.1 Member of the choloylglycine hydrolase family, which cleave carbon-nitrogen non-peptide bonds in linear amides, has moderate similarity to acid ceramidase (human ASAH), which is an apoptosis inhibitor associated with Farber disease F27E5.2 F27E5.2 Protein containing a homeobox domain (homeodomain), which are found in transcription factors, and a paired box (PAX) domain, has low similarity to paired box homeotic gene 6 (rat Pax6), which is required for eye and nose development 'Paired box' domain, homeobox protein (paired subfamily); pax-3 encodes a divergent paired-like homeodomain protein that does not belong to the Q50, K50, or S50 classes; PAX-3 is required for locomotion and vulval development; pax-3(RNAi) animals have consistent Pvl and Unc phenotypes (as well as less consistent Bmd, Rup, and Stp phenotypes). F27E5.3 F27E5.3 Protein of unknown function homeobox domain F27E5.4 F27E5.4 Protein with weak similarity to human GAS1 (growth arrest-specific 1) growth arrest protein extracellular domain F27E5.5 F27E5.5 G protein-coupled receptor, member of a subfamily with SRB proteins which are expressed in chemosensory neurons, no homolog found in human or D. melanogaster F28A10.1 F28A10.1 Protein of unknown function, putative paralog of C. elegans W09C3.3 F28A10.10 F28A10.10 Protein with strong similarity to D. melanogaster CG18330 (CG18330 gene product) cytidylyltransferase F28A10.2 F28A10.2 Protein with strong similarity to C. elegans Y39F10A.3 F28A10.3 F28A10.3 Protein of unknown function, has weak similarity to C. elegans F10A3.1 F28A10.4 F28A10.4 Protein of unknown function, has strong similarity to C. elegans T23E1.2 F28A10.5 F28A10.5 Protein of unknown function, putative paralog of C. elegans K06H6.2 F28A10.6 F28A10.6 Putative ortholog of H. sapiens ACAD8 (acyl-Coenzyme A dehydrogenase family, member 8) acyl-coA dehydrogenase F28A10.7 F28A10.7 Protein of unknown function F28A10.8 F28A10.8 Protein of unknown function, has strong similarity to C. elegans T02H6.9 membrane protein F28A10.9 F28A10.9 Putative paralog of C. elegans T07D3.4 F28A12.1 F28A12.1 Member of the amiloride-sensitive sodium channel family, has similarity to human and D. melanogaster amiloride-sensitive cation channels F28A12.2 F28A12.2 Protein of unknown function containing a Ground-like domain, has weak similarity to C. elegans Y47D7A_146.B F28A12.3 F28A12.3 Protein of unknown function, has high similarity to uncharacterized C. elegans F35C5.11 F28A12.4 F28A12.4 Protein with high similarity to C. elegans ASP-6, which is an aspartic-type endopeptidase involved in protein degradation, member of the aspartyl (acid) protease family, which include pepsins, cathepsins and renins peptidase F28B1.1 F28B1.1 Putative ortholog of C. elegans F28B1.2 gene product F28B1.2 F28B1.2 Putative ortholog of C. elegans F28B1.1 gene product F28B1.3 F28B1.3 Putative ortholog of C. elegans F28B1.4 gene product F28B1.4 F28B1.4 Putative ortholog of C. elegans F28B1.3 gene product F28B1.5 F28B1.5 Putative ortholog of C. elegans F28B1.3 gene product F28B1.6 F28B1.6 Member of the 7-transmembrane chemoreceptor family of G protein-coupled receptors (GPCR) 7TM chemoreceptor, sri family F28B12.1 F28B12.1 Protein of unknown function F28B12.2 egl-44;F28B12.2 Transcription enhancer factor-1-like protein; acts in the HSN neuron development pathway; mutations lead to abnormal HSN neuron outgrowth and serotonin expression Transcriptional enhancer factor (TEF-1); The egl-44 gene encodes a putative transcription regulatory protein of 471 amino acids similar to vertebrate transcription enhancer factor (TEF) proteins. F28B12.3 F28B12.3 Protein containing a protein kinase domain, has a region of low similarity to vaccinia related kinase 1 (human VRK1), which is a nuclear serine-threonine protein kinase that may act in human TP53 activation, signal transduction, or cellular proliferation Protein kinase F28B3.1 F28B3.1 Member of the AMP-binding enzyme family, has high similarity to uncharacterized human KIAA0934 F28B3.10 F28B3.10 Protein with strong similarity to C. elegans F28B3.6 gene product F28B3.2 F28B3.2 Protein of unknown function F28B3.3 F28B3.3 Protein of unknown function F28B3.4 F28B3.4 Protein of unknown function F28B3.5 F28B3.5 Protein of unknown function, has low similarity to uncharacterized C. elegans C27H5.4 F28B3.6 F28B3.6 Protein with strong similarity to C. elegans F28B3.10 gene product F28B3.7 F28B3.7 Protein containing an SMC domain N-terminal domain and an SMC domain C-terminal domain, which bind ATP in chromosome-associated proteins, has moderate similarity to structural maintenance of chromosomes 1-like 1 (mouse Smc1l1), which binds chromatin him-1 encodes a homolog of the conserved eukaryotic protein, SMC1, a member of the SMC (structural maintenance of chromosomes) superfamily that is required for embryonic viability, germline mitosis, chromosome pairing, and the segregation of mitotic chromosomes; HIM-1 can interact with SMC-3 and is required for DPY-28 localization to meiotic chromosomes; associates with the chromatin of transition-zone nuclei. F28B3.8 F28B3.8 Protein with weak similarity to C. elegans R06A4.4 gene product importin beta, nuclear transport factor F28B3.9 F28B3.9 Protein with moderate similarity to C. elegans F55A11.5 gene product F28B4.1 F28B4.1 Protein of unknown function F28B4.2 F28B4.2 Protein containing a Ras association domain, a ras guanine nucleotide exchange factor domain, and a ras guanine nucleotide exchange factors N-terminal domain, has low similarity to ral guanine nucleotide dissociation stimulator (rat Ralgds) guanine-nucleotide releasing factor F28B4.3 F28B4.3 Protein containing two epidermal growth factor (EGF)-like domains, a von Willebrand factor (vWF) type A domain, and a C-type lectin domain, which mediate calcium-dependent carbohydrate recognition, has high similarity to uncharacterized C. elegans F40F4.6 EGF-like repeat F28B4.4 F28B4.4 Protein with moderate similarity to C. elegans myo2-B gene product F28C1.1 F28C1.1 Protein with low similarity to suppressor of white apricot homolog 2 (mouse Swap2), which functions as an alternative splicing regulator F28C1.2 egl-10;F28C1.2 Member of the RGS, Regulator of G protein signaling, protein family G-protein beta subunit GPB-2; egl-10 encodes an RGS protein, expressed in neurons, that affects egg laying and negatively regulates GOA-1 (Galpha[o]) signalling; it requires the Gbeta(5) ortholog GPB-2 for this activity, and genetically interacts with the egl-30 and goa-1 signaling pathways. F28C1.3 F28C1.3 Protein with weak similarity to C. elegans C29E4.3 gene product Leucine Rich Repeat (2 copies) (3 domains) F28C10.1 F28C10.1 Protein of unknown function F28C10.2 F28C10.2 Protein with moderate similarity to C. elegans T23E7.1 gene product F28C10.3 F28C10.3 Protein containing a protein kinase domain, has low similarity to serum-glucocorticoid regulated kinase 2 (human SGK2), which is a serine-threonine kinase that may be regulated by 3-phosphoinositide-dependent kinase-1 (human PDK1) and by hydrogen peroxide protein kinase F28C10.4 F28C10.4 Protein of unknown function F28C12.1 F28C12.1 Member of C. elegans Sra integral membrane protein family, which contain 6-7 hydrophobic, putative transmembrane, regions, has high similarity to uncharacterized C. elegans T26E3.9 7TM chemoreceptor, sra family F28C12.2 F28C12.2 Member of C. elegans Sra integral membrane protein family, which contain 6-7 hydrophobic, putative transmembrane, regions, has high similarity to uncharacterized C. elegans T06G6.1 7TM chemoreceptor, sra family F28C12.3 F28C12.3 Protein of unknown function, has high similarity to uncharacterized C. elegans F28C12.2 F28C12.4 F28C12.4 Member of C. elegans Sra integral membrane protein family, which contain 6-7 hydrophobic, putative transmembrane, regions, has high similarity to uncharacterized C. elegans T06G6.2 7TM chemoreceptor, sra family F28C12.5 F28C12.5 Member of C. elegans Sra integral membrane protein family, which contain 6-7 hydrophobic, putative transmembrane, regions, has high similarity to uncharacterized C. elegans T06G6.1 7TM chemoreceptor, sra family F28C12.6 F28C12.6 Protein of unknown function, has moderate similarity to C. elegans Y50E8A.J F28C12.7 F28C12.7 Protein of unknown function, has high similarity to uncharacterized C. elegans F28C12.5 7TM chemoreceptor, sra family F28C6.1 F28C6.1 Protein of unknown function, has a region of low similarity to a region of transcription factor activator protein 2 alpha (mouse Tcfap2a), which regulates transcription of many genes involved in growth, development and inflammation transcription factor AP-2 like F28C6.10 F28C6.10 Protein with weak similarity to C. elegans Y8A9A.F F28C6.2 F28C6.2 Protein of unknown function, has a region of low similarity to a region of transcription factor AP-2 gamma (human TFAP2C), which regulates transcription of the estrogen receptor gene in hormonally responsive breast and endometrial carcinomas transcription factor AP-2 like F28C6.3 F28C6.3 Protein with high similarity to cleavage stimulation factor subunit 1 (human CSTF1), which is a subunit of the cleavage stimulation factor complex required for pre-mRNA polyadenylation and 3'-end cleavage, contains six WD domains (WD-40 repeat) cleavage stimulation factor like F28C6.4 F28C6.4 Protein with low similarity to S. cerevisiae Las21p, which is required for addition of a side chain to the glycosylphosphatidylinositol (GPI) core structure Yeast YJ10 like F28C6.5 F28C6.5 Protein of unknown function F28C6.6 suf-1;F28C6.6 Protein with high similarity to cleavage stimulation factor subunit 3 (human CSTF3), which is the 77 kDa subunit of the cleavage stimulation factor required for polyadenylation and 3'-end cleavage of pre-mRNA polyadenylation factor like F28C6.7 F28C6.7 Protein with high similarity to ribosomal protein L26 (yeast L33, YL33, S. cerevisiae Rpl26bp, member of the KOW (Kyprides-Ouzounis-Woese) motif family, which are either part of the large ribosomal subunit or transcriptional antitermination proteins ribosomal protein L26 like; rpl-26 encodes a large ribosomal subunit L26 protein; by homology, RPL-26 is predicted to function in protein biosynthesis; in C. elegans, RPL-26 activity is required for embryonic and germline development and normal rates of postembryonic growth. F28C6.8 F28C6.8 Protein containing a dual specificity phosphatase catalytic domain MAP kinase phosphatase like F28C6.9 F28C6.9 Protein of unknown function, has weak similarity to C. elegans C40H1.3 F28D1.1 F28D1.1 Putative ortholog of S. cerevisiae Yer082p, a nonessential protein of unknown function Yeast hypothetical protein YER2 like F28D1.10 gex-3;F28D1.10 Putative ortholog of Drosophila HEM protein, a transmembrane domain containing protein Drosophila dhem transmembrane protein like; The gex-3 gene encodes a homolog of NAP1/NCKAP1, a mammalian protein ligand of the small GTPase Rac1, and of Drosophila HEM2/NAP1/KETTE; gex-3 is required for tissue morphogenesis and cell migrations; in gex-3 mutants, cells differentiate properly but fail to become organized. F28D1.11 F28D1.11 Protein of unknown function F28D1.2 F28D1.2 Protein of unknown function F28D1.3 F28D1.3 Member of the thaumatin family of plant pathogenesis associated (PR) proteins, has strong similarity to uncharacterized C. elegans F28D1.5 Arabidopsis pathogenesis-related protein 5 like F28D1.4 F28D1.4 Member of the thaumatin family of plant pathogenesis associated (PR) proteins, has high similarity to uncharacterized C. elegans F28D1.3 Arabidopsis pathogenesis-related protein 5 like F28D1.5 F28D1.5 Member of the thaumatin family of plant pathogenesis associated (PR) proteins, has strong similarity to uncharacterized C. elegans F28D1.3 Arabidopsis pathogenesis-related protein 5 like F28D1.6 F28D1.6 Protein of unknown function F28D1.7 F28D1.7 Member of the ribosomal protein S23 protein family ribosomal protein S23; rps-23 encodes a small ribosomal subunit S23 protein; by homology, RPS-23 is predicted to function in protein biosynthesis; in C. elegans, RPS-23 activity is required for germline development, vulval morphogenesis, and the overall health of the animal. F28D1.8 F28D1.8 Protein of unknown function F28D1.9 ceFATPa;F28D1.9 Fatty acid transport protein fatty acid transport protein F28D9.1 rsr-1;CeSRm160;F28D9.1 Contains a putative PWI (splicing factor) domain, has strong similarity to human Hs.18192 protein, an SR-like protein (SRM160) associated with splicing complexes F28D9.2 F28D9.2 Member of the 7-transmembrane chemoreceptor family of G protein-coupled receptors (GPCR), has moderate similarity to uncharacterized C. elegans F15H9.4 7TM chemoreceptor, sri family F28D9.4 F28D9.4 Protein of unknown function F28E10.1 F28E10.1 Protein with weak similarity to C. elegans unc-89, a muscle cell protein of the immunoglobulin-like protein family that is required for coordinated locomotion F28E10.2 F28E10.2 Protein containing an immunoglobulin (Ig) domain, which may be involved in protein-protein and protein-ligand interactions F28E10.3 F28E10.3 Member of the reverse transcriptase protein family, which are RNA-dependent DNA polymerases, has very strong similarity to uncharacterized C. elegans F47C8.1 F28E10.4 F28E10.4 Protein of unknown function, possible paralog of C. elegans C46H11.6 F28F5.1 F28F5.1 Protein of unknown function F28F5.3 F28F5.3 Protein with weak similarity to H. sapiens Hs.22599 (Homo sapiens mRNA for KIAA0705 protein, complete cds) F28F5.4 F28F5.4 Protein of unknown function F28F8.1 acr-18;F28F8.1 Protein containing a neurotransmitter-gated ion-channel ligand binding domain, has low similarity to C. elegans ACR-16, which is a nicotinic acetylcholine receptor alpha-1 subunit acetylcholine receptor; acr-18 encodes an alpha subunit of nicotinic acetylcholine receptor (nAChR), predicted to be a ligand-gated ion channel regulating fast action of acetylcholine at neuromuscular junctions and in the nervous system; ACR-18 falls into the 'DEG-3' class of nAChR subunits, apparently unique to nematodes, which includes DEG-3, DES-2, ACR-5, ACR-17, ACR-20, and ACR-23. F28F8.2 F28F8.2 Member of the AMP-binding enzyme family, has weak similarity to S. cerevisiae Fat2p, which is a peroxisomal AMP-binding protein long-chain-fatty-acid-CoA ligase F28F8.3 F28F8.3 Protein with high similarity to U6 snRNA-associated Sm-like protein (human LSM5), which is a putative RNA-binding protein that forms a doughnut-shaped U6 snRNA-containing complex with other Sm-like proteins, member of the Sm family small nuclear ribonucleoprotein E (SNRNP-E) like F28F8.4 F28F8.4 Protein of unknown function, has moderate similarity to C. elegans F44G3.8 This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins; this gene's encoded protein also contains an FTH/DUF38 motif, which may also mediate protein-protein interaction. F28F8.5 F28F8.5 Protein of unknown function F28F8.6 F28F8.6 Member of the Josephin family, contains two ubiquitin interaction motifs, has low similarity to Machado-Joseph disease (spinocerebellar ataxia 3) (human MJD), which is involved in neurogenesis and synaptic transmission Human Machedo-Joseph disease protein 1 like; tag-70/F28F8.6 encodes an ortholog of human ATAXIN-3 (OMIM:607047, mutated in Machado-Joseph disease). F28F8.7 F28F8.7 Protein of unknown function, has strong similarity to C. elegans Y105C5.A F28F9.1 F28F9.1 Homeodomain transcription factor, has similarity over 806 amino acids to D. melanogaster ZFH2 (Zn finger homeodomain) transcription factor zinc-finger homeodomain protein; zag-1 encodes a homeodomain protein of the ZFH class which consists of a homeodomain flanked by two clusters of C2H2-type zinc fingers and is related to transcriptional repressors encoded by Drosophila zfh-1 and the vertebrate ZEB genes; ZAG-1 is required for locomotion, for neuronal differentiation, and for proper axonal branching and fasciculation; from late embryogenesis through adult stages of development, ZAG-1 is expressed dynamically in head and tail neurons and in the intestinal and anal depressor muscles. F28F9.2 F28F9.2 Protein of unknown function F28F9.3 F28F9.3 Protein of unknown function F28F9.4 F28F9.4 Member of the amino acid permease family, has strong similarity to human cationic amino acid transporters, has moderate similarity to yeast methionine transporters amino acid permease F28G4.1 F28G4.1 Member of the cytochrome P450 family, has low similarity to cytochrome P450 subfamily 4F polypeptide 2 (human CYP4F2), which is an arachidonic acid- and leukotriene B4 omega-hydroxylase that regulates salt and water homeostasis in the liver and kidney cytochrome P450 F28G4.2 F28G4.2 Protein of unknown function, has high similarity to uncharacterized C. elegans F28G4.4 F28G4.3 F28G4.3 Member of an uncharacterized protein family F28G4.4 F28G4.4 Member of an uncharacterized protein family F28G4.5 F28G4.5 Member of the uncharacterized protein family UPF0063, has high similarity to uncharacterized C. elegans C31A11.1 F28H1.1 F28H1.1 Protein of unknown function F28H1.2 F28H1.2 Protein containing a calponin homology (CH) domain, has low similarity to a region of calponin 1 (mouse Cnn1), which is an actin-binding protein expressed in smooth muscle cells that may be involved in bone, heart, and muscle development calponin; cpn-3 encodes a calponin homolog, most closely related to its paralog CPN-4 in C. elegans; CPN-3 is more similar to the calponin paralogs transgelin (SM22 alpha) or neuronal protein NP25 than to calponin per se. F28H1.3 F28H1.3 Protein with high similarity to alanyl-tRNA synthetase (human AARS), which aminoacylates its cognate tRNA with alanine for protein biosynthesis, member of the class II alanyl (A)-tRNA synthetase family, contains a DHH-associated (DHHA1) domain aminoacyl-tRNA synthetase; ars-2 encodes a predicted cytoplasmic alanyl-tRNA synthetase (AlaRS), a class II aminoacyl-tRNA synthetase that catalyzes the attachment of alanine to its cognate tRNA and is thus required for protein biosynthesis; ARS-2 is essential for embryogenesis, and is required for fertility and a normal rate of postembryonic development; ARS-2 expression is likely ubiquitous and detected in hypodermis, intestine, neurons, and the pharynx from late embryogenesis through the adult stage of development. F28H1.4 F28H1.4 Protein of unknown function, has strong similarity to C. elegans F47B3.3 F28H1.5 F28H1.5 Protein of unknown function F28H6.1 akt-2;F28H6.1 Serine/threonine protein kinase that transduces signal from AGE-1 to antagonize DAF-16 transcription factor; member of Akt/PKB subfamily of serine/threonine protein kinases PH (pleckstrin homology) domain, Protein kinase C terminal domain; akt-2 encodes a homolog of the serine/threonine kinase Akt/PKB, AKT-2, that is required for progression through the dauer stage of development and for the negative regulation of adult lifespan; inactivation of akt-2 causes animals to arrest constitutively at the dauer stage, while having an increased life span; widely expressed, AKT-2 is activated by the phospholipid products of phosphoinositide 3-kinase AGE-1/PI3K and by PDK-1, a homolog of vertebrate 3-phosphoinositide-dependent kinase-1 (PDK-1) Normal akt-2 (and akt-1) activity is required for excess pdk-1 activity to suppress the dauer-arrest phenotype of age-1, indicating that the 3-phosphoinositide-dependent kinase-1 homolog PDK-1 transduces signals from AGE-1 to AKT-2 (and AKT-1); conversely, the akt-2 loss-of-function phenotype is suppressed by daf-16 null mutations, indicating that the Fork head transcription factor DAF-16 is downstream of AKT-2 (and AKT-1), and that AKT-1 and AKT-2 act primarily to antagonize DAF-16. F28H6.2 F28H6.2 Protein of unknown function F28H6.3 F28H6.3 Protein containing an aminotransferase class I and II domain, has moderate similarity to cysteine conjugate beta-lyase (human CCBL1), which metabolizes alkane and alkene S-conjugates and activates nephrotoxic metabolites Aminotransferases class-I F28H6.4 F28H6.4 Putative ortholog of C. elegans F28H6.5 gene product F28H6.6 F28H6.6 Protein of unknown function, has weak similarity to C. elegans T10D4.6 F28H6.7 F28H6.7 Protein of unknown function F28H7.1 F28H7.1 Member of the 7-transmembrane chemoreceptor family of G protein-coupled receptors (GPCR), has high similarity to uncharacterized C. elegans R09B5.7 F28H7.10 F28H7.10 Member of the ion transport family, which include calcium, sodium, and potassium channels, contains three ankyrin (Ank) repeats, has low similarity to C. elegans OSM-9, which is required for mechanosensation and olfactory and avoidance responses ankyrin repeats F28H7.11 F28H7.11 Member of the 7-transmembrane chemoreceptor family of G protein-coupled receptors (GPCR), has weak similarity to C. elegans ODR-10, which is involved in odorant response F28H7.2 F28H7.2 Member of the short-chain dehydrogenase-reductase family, which are NAD- or NADP-dependent oxidoreductases, has low similarity to human HSA250303, which is a peroxisomal trans 2-enoyl CoA reductase that catalyzes the reduction of trans 2-enoyl CoAs glucose-1-dehydrogenase; This gene encodes a protein predicted by Eisenberg and coworkers, with 68% accuracy, to be mitochondrial. F28H7.3 F28H7.3 Member of the lipase class 3 family, which are a subset of lipolytic enzymes that hydrolyze ester linkages of triglycerides, has high similarity to uncharacterized C. elegans B0035.13 lipase F28H7.4 F28H7.4 Protein of unknown function, has moderate similarity to uncharacterized C. elegans C35C5.3 F28H7.6 F28H7.6 Protein of unknown function F28H7.7 F28H7.7 Member of an uncharacterized protein family F28H7.8 F28H7.8 Protein containing a TRAL-CRIO domain, has a region of low similarity to rat AJ132352, which is a 45 kD secretory protein from olfactory epithelium that has high affinity GTP binding and low GTPase activity F28H7.9 F28H7.9 Member of the C. elegans Sre G protein-coupled chemoreceptor family, which are putative chemosensory receptors, has moderate similarity to uncharacterized C. elegans F40G12.1 7TM receptor, sre family F29A7.1 F29A7.1 Protein containing an F-box domain, which serve as a link between a target protein and a ubiquitin-conjugating enzyme, has moderate similarity to uncharacterized C. elegans F08D12.8 This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins; its encoded protein also contains a Pfam-B45 motif of presently unknown function. F29A7.2 F29A7.2 Protein of unknown function, has low similarity to uncharacterized C. elegans F29A7.1 F29A7.3 F29A7.3 Protein with strong similarity to C. elegans F26F2.6 gene product F29A7.4 F29A7.4 Protein of unknown function F29A7.5 F29A7.5 Protein of unknown function F29A7.6 F29A7.6;2D42 Protein of unknown function F29A7.7 F29A7.7 Protein containing a C-type lectin domain, which mediate calcium-dependent carbohydrate recognition F29A7.8 F29A7.8 Protein of unknown function, has weak similarity to C. elegans F11D11.7 F29B9.1 F29B9.1 Protein of unknown function, has low similarity to uncharacterized S. cerevisiae Yil064p F29B9.10 F29B9.10 Possible mitochondrial small ribosomal subunit protein F29B9.11 F29B9.11 Protein of unknown function F29B9.2 F29B9.2 Protein containing two Jumonji (jmjC) domains F29B9.4 F29B9.4 Similar to the human phosphatidyl serine receptor, PSR, which is expressed on phagocytes and critical for the removal of apoptotic cells psr-1 encodes an ortholog of the mammalian apoptotic phosphatidylserine receptor, whose product recognizes phosphatidylserine on apoptotic cells and enables cells expressing the receptor to recognize and engulf apoptotic cells in a phosphatidylserine-specific manner; psr-1 was not mutated in classical screens for Ced mutants, but, given its high similarity, may nevertheless mediate phosphatidylserine recognition on apoptotic cells during their removal by phagocytes. F29B9.5 F29B9.5 Protein with high similarity to C. elegans R05H5.3, which is a putative nuclear thioredoxin involved in embryogenesis and morphogenesis, member of the thioredoxin family, which are small enzymes involved in redox reactions F29B9.6 ubc-9;F29B9.6 Protein with high similarity to ubiquitin-conjugating enzyme E2I (human UBE2I), which catalyzes the ubiquitination of cellular proteins and may play a role in the cell cycle, member of the ubiquitin-conjugating enzyme (E2) family ubiquitin-conjugating enzyme; ubc-9 encodes an E2 ubiquitin-conjugating enzyme orthologous to Saccharomyces cerevisiae Ubc9p, which mediates the covalent attachment of the small ubiquitin-related modifier (SUMO) to various substrates including Ran-GAP1 and p53; UBC-9 activity is required for several developmental processes including embryogenesis, larval development, vulval development, posterior morphogenesis, and the DNA damage response (both DNA repair and DNA damage checkpoint function); UBC-9 interacts with LIN-1, an ETS-domain-containing transcription factor that negatively regulates vulval development, and with RAD-51, the C. elegans RecA homolog that is required for DNA repair; the expression pattern and subcellular localization of UBC-9 are not yet known. F29B9.7 F29B9.7 Protein of unknown function F29B9.8 F29B9.8 Protein of unknown function F29B9.9 F29B9.9 Protein containing two collagen triple helix repeats and one nematode cuticle collagen N-terminal domain, has moderate similarity to a region of C. elegans BLI-1, which is a putative collagen involved in embryogenesis and morphogenesis and chemotaxis collagen F29C12.1 F29C12.1 Protein containing a DB module domain The protein product of this gene is predicted to contain a glutamine/asparagine (Q/N)-rich ('prion') domain, by the algorithm of Michelitsch and Weissman (as of the WS77 release of WormBase, i.e., in wormpep77). F29C12.2 F29C12.2 Protein of unknown function, has a region of weak similarity to a region of S. pombe Ste20p, which is involved in mating and meiosis F29C12.3 F29C12.3 Protein of unknown function F29C12.4 F29C12.4 Protein with high similarity to mitochondrial translation elongation factor G (S. cerevisiae Mef1p), which promotes nascent chain translocation, contains elongation factor Tu GTP binding and domain 2 domains and an elongation factor G C-terminal domain Elongation factor Tu family (contains ATP/GTP binding P-loop), Elongation factor G C-terminus F29C12.5 F29C12.5 Protein containing two BTB (BR-C, ttk and babor) or POZ (Pox virus and zinc finger) domains, which may mediate protein-protein interactions, and a meprin and TRAF homology (MATH) domain, has low similarity to uncharacterized C. elegans F59H6.10 BTB (also known as BR-C/Ttk) domain. (2 domains) F29C12.6 F29C12.6 Protein of unknown function F29C4.1 daf-1;F29C4.1 Putative type I TGF-beta-receptor with strong similarity to C. elegans SMA-6 (a receptor serine/threonine protein kinase) that acts with DAF-7 and DAF-4 to repress dauer formation protein kinase; daf-1 encodes a TGF-beta type I receptor homolog required, in association with the TGF beta-like type II receptor DAF-4, for the regulation of dauer formation by environmental signals through the ASI chemosensory neuron; DAF-1 is bound by BRA-1 and has an intracellular serine-threonine kinase domain; mutations in daf-1 result in constitutive formation of dauer larvae even in abundant food. F29C4.2 F29C4.2 Protein of unknown function, has high similarity to uncharacterized C. elegans Y111B2A.2 F29C4.4 F29C4.4 Protein of unknown function F29C4.5 F29C4.5 Member of the ubiquitin carboxyl-terminal hydrolase family 2 and the ovarian tumor (OTU)-like cysteine protease family, contains a ubiquitin carboxyl-terminal hydrolases family 2 domain, has high similarity to uncharacterized C. elegans F38B7.5 F29C4.6 F29C4.6 Putative ortholog of S. cerevisiae Ygl211p, a protein of unknown function F29C4.7 F29C4.7 Protein containing two RNA recognition motifs (RRM, RBD, or RNP), has a region of low similarity to a region of SMRT and HDAC1 associated repressor protein (human SHARP), which is a transcriptional repressor that also regulates nuclear receptors RNA-binding protein F29C4.8 F29C4.8 Protein containing six collagen triple helix repeats, has moderate similarity to type IX collagen alpha 2 (human COL9A2), which is a cartilage extracellular matrix component that may be associated with epiphyseal dysplasia and invertebral disc disease F29D10.1 F29D10.1 Protein of unknown function F29D10.2 F29D10.2 Protein of unknown function F29D10.3 F29D10.3 Protein with similarity to members of the C-type lectin family F29D10.4 hum-1;F29D10.4 Myosin I, class I unconventional myosin heavy chain myosin F29D10.5 F29D10.5 Protein containing two C2H2-type zinc finger domains and a BED zinc finger domain F29D11.1 lrp-1;LRP;F29D11.1 Low density lipoprotein receptor-related protein (LRP); gp330/megalin-related protein; member of EGF-like repeat protein family, has strong similarity to human low density lipoprotein receptor-related proteins low density lipid receptor-rlated protein F29D11.2 F29D11.2 Protein of unknown function F29F11.1 F29F11.1 Protein with high similarity to mouse Ugdh, which is a UDP-glucose dehydrogenase that converts UDP-glucose to UDP-glucuronate, member of the UDP-glucose or GDP-mannose dehydrogenase family, which catalyze the NAD-dependent oxidation of an alcohol UDP-glucose dehydrogenase; sqv-4 encodes a UDP-glucose 6-dehydrogenase, biochemically active in vitro, that is required for cytokinesis of one-cell embryos and for vulval morphogenesis; SQV-4 is orthologous to Drosophila SUGARLESS, human UGDH (OMIM:603370), and zebrafish JEKYLL; SQV-4 is expressed in many cell types, notably oocytes and uterine, seam, pharyngeal, and spermathecal cells, with expression being prominent in 14 of the 22 vulval nuclei of late L4 larvae; the common requirement for SQV-4 in both cytokinesis and morphogenesis may be to promote filling an extracellular space with hygroscopic proteoglycans (either in the eggshell, or underneath the L4 cuticle), which in turn may cause the space to fill with fluid. F29F11.2 F29F11.2 Protein containing two UDP-glucoronosyl and UDP-glucosyl transferase domains, has a region of low similarity to glucuronosyltransferase 2B family member 5 (mouse Ugt2b5), which conjugates lipophilic aglycon substrates with glucuronic acid UDP-glucuronosyltransferase F29F11.3 F29F11.3 Protein of unknown function, has weak similarity to S. cerevisiae Ynl119p F29F11.4 twk-9;F29F11.4 Member of the 4 TM potassium channel protein family potassium channel protein like; twk-12 encodes one of 44 C. elegans TWK (two-P domain K+) potassium channel subunits that contain two pore-forming domains and four transmembrane domains; as loss of TWK-12 function via RNA-mediated interference (RNAi) does not result in any abnormalities, the precise role of TWK-12 in C. elegans development and/or behavior is not yet known; TWK-12 may, however, function redundantly with other TWK channels; the TWK-12 expression pattern has not been determined. F29F11.5 ceh-22;F29F11.5 Homeodomain transcription factor involved in pharyngeal muscle development, has similarity over the homeodomain to many human and D. melanogaster homeodomain transcription factors homeobox protein (NK-2 subfamily); The ceh-22 gene encodes a NK-2 family homeodomain factor homologous to Drosophila TINMAN and vertebrate Nkx2-5 proteins. F29F11.6 CeGLC-7a;F29F11.6 PP1-beta serine/threonine protein phosphatase serine/threonine protein phosphatase F29G6.1 F29G6.1 Protein containing 14 Kazal-type serine protease inhibitor domains, has a region of weak similarity to a region of rat Agrn, which is a basal lamina proteoglycan that stimulates acetylcholine receptor aggregation via rat MUSK and acts in synaptogenesis kazal-type proteinase inhibitor F29G6.2 F29G6.2 Putative coiled-coil protein, has weak similarity to mammalian integrin F29G6.3 F29G6.3 Protein containing eight YLP motifs F29G9.1 F29G9.1 Protein of unknown function, has moderate similarity to uncharacterized C. elegans Y24F12A.4 F29G9.2 F29G9.2 Protein of unknown function, has moderate similarity to H. sapiens Hs.66713 gene product, which interacts with hepatitis delta antigen F29G9.3 F29G9.3 Protein with strong similarity to adaptor protein complex 1 sigma 1 subunit (human AP1S1), which binds to gamma-adaptin (AP1G1) and enhances AP-1 adaptor complex assembly, member of the clathrin adaptor complex small chain family clathrin coat assembly protein; The apt-2 gene encodes an adaptin: specifically, it encodes an ortholog of the sigma1 subunit of adaptor protein complex 1 (AP-1). F29G9.4 F29G9.4 Protein containing a bZIP (basic-leucine zipper) transcription factor domain BZIP transcription factor F29G9.5 rpt-2;F29G9.5 Putative ATPase subunit of 19S proteasome particle ATPase F29G9.6 F29G9.6 Member of an uncharacterized protein family dhs-17 encodes a member of the short-chain dehydrogenases/reductases family (SDR). F29G9.7 F29G9.7 Protein of unknown function, has strong similarity to uncharacterized C. elegans T10C6.9 This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins; its encoded protein also contains a Pfam-B45 motif of presently unknown function. F30A10.1 F30A10.1 Member of an uncharacterized protein family calcineurin B subunit like F30A10.10 F30A10.10 Protein containing one ubiquitin carboxyl-terminal hydrolases family 2 domain and one ubiquitin interaction motif, has a region of low similarity to a region of S. cerevisiae Ubp15p, which is a putative ubiquitin-specific protease ubiquitin carboxyl-termianl hydrolase F30A10.2 F30A10.2 Protein of unknown function F30A10.3 F30A10.3 Protein with low similarity to inositol hexakisphosphate kinase 1 (mouse Ip6k1), which displays ATP synthase activity and phosphorylates inositol hexakisphosphate to yield diphosphoinositol pentakisphosphate F30A10.4 F30A10.4 Member of the core-2 or I-branching enzyme family, which form blood group I-antigens or side-chains of O-glycans, has weak similarity to core 2 beta-1,6-N-acetylglucosaminyltransferase 3 (human LOC51301), which catalyzes core 2 O-glycan branch formation acetylglucosaminyltransferase F30A10.5 stl-1;F30A10.5 Protein with high similarity to stomatin-like 2 (human STOML2), which may link integral membrane proteins to the peripheral cytoskeleton and affect channel conductance or membrane organization, member of the SPFH domain or Band 7 family erythrocyte band 7 integral membrane protein like F30A10.6 F30A10.6 Protein with high similarity to supressor of actin 1 (rat Sacm1l), which is an integral membrane lipid phosphatase that acts on PI 3 phosphate, PI 4 phosphate, and PI 3,5 bisphosphate, contains a SacI homology domain Yeast recessive suppressor RSD1 like F30A10.7 F30A10.7 Member of the retroviral aspartyl protease family, contains a zinc knuckle domain, which can bind RNA or DNA in eukaryotes, has very strong similarity to uncharacterized C. elegans K02F6.1 Retroviral aspartyl proteases, Zinc finger, CCHC class F30A10.8 F30A10.8 Ortholog of human syntrophin PDZ domain (Also known as DHR or GLGF). F30A10.9 F30A10.9 Putative ortholog of S. cerevisiae Ydr339p, a protein of unknown function Yeast D96591.6 protein like F30B5.1 dpy-16;dpy-13;F30B5.1 Collagen, member of the collagen triple helix repeat (20 copies) family cuticular collagen; dpy-13 encodes a member of the collagen superfamily containing 20 copies of the collagen triple helix repeat; transcipt levels oscillate, peaking once during each larval stage. F30B5.4 F30B5.4 Protein of unknown function, has similarity to human HS.40539 (chromosome 8 open reading frame 1) F30B5.5 F30B5.5 Member of the transposase family, which are required for excising and inserting mobile genetic elements, contains an F-box domain, which serve as a link between a target protein and a ubiquitin-conjugating enzyme F30B5.6 F30B5.6 G protein-coupled receptor of an unnamed subfamily, no homolog found in human or D. melanogaster F30B5.7 F30B5.7 Member of the ZIP zinc transporter family, which may be metal transporters, has low similarity to uncharacterized C. elegans F55F8.9 F30F8.1 F30F8.1 Protein of unknown function F30F8.2 F30F8.2 Protein with high similarity to kidney-type glutaminase (human GLS), which catalyzes the hydrolysis of glutamine to provide TCA cycle intermediates, maintain acid-base balance and produce neurotransmitters, contains three ankyrin (Ank) repeats glutaminase F30F8.3 F30F8.3 Protein containing a PDZ, DHR, or GLGF domain, which are found in signaling proteins PDZ domain (Also known as DHR or GLGF). F30F8.4 F30F8.4 Member of the transposase protein family transposon Tc4 F30F8.5 F30F8.5 Protein of unknown function F30F8.7 F30F8.7 Protein of unknown function F30F8.8 taf-4;F30F8.8 Protein containing five WD domains (WD-40 repeat), which may mediate protein-protein interactions, has low similarity to TATA box binding protein (TBP)-associated factor (human TAF5), which may help stabilize interactions among TBP associated factors guanine nucleotide-binding protein F30F8.9 F30F8.9 Protein of unknown function F30H5.1 unc-45;F30H5.1 Muscle-specific tetratricopeptide repeat-containing protein required for embryogenesis; a component of the thick filaments of body wall muscle sarcomeres; may be a myosin chaperone P59 protein and TPR domain F30H5.2 F30H5.2 YGGWamide neurotransmitter F30H5.3 F30H5.3 Protein containing six kunitz or bovine pancreatic trypsin inhibitor domains and three EB module domains, has a region of weak similarity to a region of notch homolog 1 (mouse Notch1), which regulates transcription in early embryonic development Serine protease inhibitor F31A3.1 F31A3.1 Glutamine and cysteine rich protein, has strong similarity to serveral C. elegans proteins, including Y105C5.C, Y105C5.D, Y105C5.E, and Y73F8A.H cys- and gln-rich protein; abu-3 encodes a transmembrane protein with a predicted signal sequence, a glutamine/asparagine-rich domain and multiple cysteine-rich repeats (DUF139); abu-3 expression is induced by blockage of the unfolded-protein response in the endoplasmic reticulum (ER), and ABU-3 may function within the ER to protect the organism from damage by improperly folded nascent protein; abu-3 expression is enhanced in ER-stressed animals in which the unfolded protein response (UPR) is blocked by mutations in xbp-1, a bZIP transcription factor. F31A3.2 F31A3.2 Protein containing a helix-loop-helix DNA-binding domain, which mediate protein dimerization, has very strong similarity to uncharacterized C. elegans F31A3.4 F31A3.3 F31A3.3 Protein of unknown function, has weak similarity to C. elegans F22H10.6 F31A3.4 F31A3.4 Protein containing a helix-loop-helix DNA-binding domain, which mediate protein dimerization, has very strong similarity to uncharacterized C. elegans F31A3.2 F31A3.5 F31A3.5 Protein of unknown function F31A9.1 F31A9.1 Protein of unknown function, has weak similarity to C. elegans F44F1.2 F31A9.2 F31A9.2 Protein of unknown function F31A9.3 arg-1;F31A9.3 Protein containing two epidermal growth factor (EGF)-like domains and a delta serrate ligand (DSL) domain, which are required for binding Notch-like receptors, has moderate similarity to C. elegans APX-1, which is ligand for the GLP-1 receptor EGF domain protein; arg-1 encodes a member of the Delta/Serrate/LAG-2 family of transmembrane signaling ligands and mediates cell fate decisions during early embryogenesis and may function in the CeTwist pathway for mesoderm development; arg-1 is closely related to apx-1 and lag-2 and is functionally interchangeable with them; ARG-1 is expressed in the vm1 vulval muscles. F31A9.4 F31A9.4 Protein of unknown function, putative paralog of C. elegans C02B8.2 F31A9.6 F31A9.6 Member of the reverse transcriptase family, which are RNA-dependent DNA polymerases, has high similarity to uncharacterized C. elegans R05F9.4 F31B12.1 plc-1;PLC210;F31B12.1 PhosphoInositide specific PhosphoLipase C; putative effector of let-60 Ras and bifunctional protein phosphoinositide-specific phospholipase C; plc-1 encodes a predicted phospholipase C that affects fertility and possesses two functional domains not commonly seen in other phospholipases: a C-terminal Ras-associating domain with structural similarity to RalGDS and AF-6, and an N-terminal CDC25-like domain that possesses structural homology to guanine nucleotide exchange proteins for Ras. F31B12.2 F31B12.2 Protein of unknown function F31B12.3 F31B12.3 Protein of unknown function frm-9 encodes a B41/ERM (ezrin/radixin/moesin) domain containing protein. F31B9.1 F31B9.1 Member of the rhodopsin family of G protein-coupled receptors (GPCR), has low similarity to tachykinin receptor 1 (substance P receptor, rat Tacr1), which is involved in pain transmission, inflammation, perception of noxious stimuli, and behavior 7 transmembrane receptor (rhodopsin family) F31B9.2 F31B9.2 Protein of unknown function, has weak similarity to C. elegans F31B9.3 F31B9.3 F31B9.3 Protein of unknown function, has weak similarity to C. elegans E03G2.1 F31C3.1 cyp-5;F31C3.1 Cyclophilin-related peptidylprolyl cis-trans-isomerase cyclophillin; cyp-5 encodes a cyclophilin that is functional in vitro and is predicted to be a secreted protein that is structurally most similar to human cyclophilin B; expressed in the intestine. F31C3.2 F31C3.2 Protein of unknown function, has a region of low similarity to a region of DNA polymerase kappa (S. pombe Cid1p), which is involved in caffeine sensitivity F31C3.3 F31C3.3 Protein of unknown function, has low similarity to uncharacterized human KIAA0100 F31C3.4 F31C3.4 Member of the ZIP zinc transporter family, which may be metal transporters, has low similarity to uncharacterized human SLC39A1 F31C3.5 F31C3.5 Protein of unknown function, has moderate similarity to uncharacterized human LOC51659 F31C3.6 F31C3.6 Protein of unknown function F31D4.1 F31D4.1 Member of the RNase PH family of 3' exoribonucleases, which are involved in RNA processing, has low similarity to opa-interacting protein 2 (human OIP2), which interacts with opacity-associated proteins on Neisseria gonorrhoeae outer membranes F31D4.2 F31D4.2 Protein of unknown function, has moderate similarity to uncharacterized human FLJ12910 F31D4.3 F31D4.3 Member of the FKBP-type peptidyl-prolyl cis-trans isomerase, contains three TPR (tetratrico peptide repeat) domains, has moderate similarity to FK506-binding protein 4 (59 kDa) (human FKBP4), which is an peptidylprolyl cis-trans isomerase immunophilin FKBP-type peptidyl-prolyl cis-trans isomerases F31D4.4 F31D4.4 Member of the C-type lectin domain protein family CUB domain, Lectin C-type domain short and long forms F31D4.5 F31D4.5 Protein containing a pleckstrin homology (PH) domain, which mediate protein-protein and protein-lipid interactions PH (pleckstrin homology) domain F31D4.6 F31D4.6 Member of the trypsin family of serine proteases serine protease F31D4.7 F31D4.7 Member of the ion transport family, which include calcium, sodium, and potassium channels, has low similarity to human KCNK1, which forms disulfide-linked homodimeric K+ channels that may function as a background or leak channel F31D4.8 F31D4.8 Protein of unknown function, has strong similarity to C. elegans W02D9.10 F31D4.9 F31D4.9 Protein of unknown function F31D5.1 F31D5.1 Member of an uncharacterized protein family F31D5.2 F31D5.2 Member of an uncharacterized protein family F31D5.3 F31D5.3 Protein of unknown function, has a region of low similarity to a region of neuronal copine VI (human CPNE6), which is a calcium-dependent phospholipid binding protein that may play a role in synaptic plasticity F31D5.4 F31D5.4 Protein containing a latrophilin or CL-1-like GPS domain, which contain GPCR proteolytic sites involved in protein ligand binding F31D5.5 F31D5.5 Protein containing a latrophilin or CL-1-like GPS domain, which contain GPCR proteolytic sites involved in protein ligand binding F31D5.6 F31D5.6 Protein of unknown function, has weak similarity to C. elegans F48C1.2 This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins. F31E3.1 ceh-20;F31E3.1 Homeodomain transcription factor, has similarity over 309 amino acids to human PBX1 pre-B-cell leukemia transcription factor, has strong similarity over 333 amino acids to D. melanogaster EXD (extradenticle) homeodomain transcription factor A co-factor homeodomain protein and homolog of Drosophila Extradenticle (Exd) that together with ceh-40 affects embryogenesis, loss of both functions affect embryonic viability; it is required as a cofactor for LIN-39- and MAB-5- dependent postembryonic mesoderm patterning; it genetically interacts with unc-62. F31E3.2 F31E3.2 Protein containing two protein kinase domains, has low similarity to S. cerevisiae Tpk2p, which is the catalytic subunit of cAMP-dependent protein kinase 2, protein kinase A, or PKA Protein kinase F31E3.3 rfc-4;F31E3.3 Member of the ATPase family associated with various cellular activities, has moderate similarity to replication factor C second subunit (S. cerevisiae Rfc2p), which may play a role in establishing sister chromatid cohesion Replication factor C F31E3.4 F31E3.4 Member of the exonuclease family, has weak similarity to S. cerevisiae Pan2p, which is a component of the S. cerevisiae Pab1p stimulated poly(A) ribonuclease and is involved in control of poly(A) tail length F31E3.5 eft-3;F31E3.5 Protein with strong similarity to eukaryotic translation elongation factor 1 alpha 2 (wasted, mouse Eef1a2), contains an elongation factor Tu GTP binding domain, an elongation factor Tu domain 2, and an elongation factor Tu C-terminal domain Elongation factor 1-alpha; eft-3 encodes a translation elongation factor 1-alpha homolog that is required for embryonic viability, fertility, and germline maintenance; the EFT-3 protein sequence is encoded both by eft-3 (F31E3.5) itself but also by R03G5.1. F31E3.6 F31E3.6 Protein of unknown function, has moderate similarity to C. elegans F22D6.13 F31E8.1 F31E8.1 Protein of unknown function F31E8.2 snt-1;ric-2;unc-121;syt1;F31E8.2 Synaptotagmin Synaptotagmin F31E8.3 tab-1;mec-16;ceh-29;F31E8.3 Protein containing a homeobox domain (homeodomain), which are found in transcription factors, has low similarity to hematopoietically expressed homeobox (rat Hhex), which is a transcriptional repressor that may function in hepatocyte differentiation Homeobox; tab-1 encodes a homeodomain protein homologous to Drosophila bsh (brain-specific homeodomain protein) and the vertebrate BarH-like homeodomain protein 1; TAB-1 is required, during early larval development, for backward movement in response to anterior touch with a wire, while during later larval stages, TAB-1 is required for response to gentle touch with a hair; TAB-1 expression begins in the early embryo in approximately 20-30 cells and is then restricted to a subset of neurons including AIB, AVJ, and RIV; TAB-1 expression in AIB may be controlled by the UNC-42 homeodomain protein and TAB-1 may autoregulate in the AVJ and RIV neurons. F31E8.4 F31E8.4;xem1-1 Protein of unknown function, has moderate similarity to C. elegans F27C1.2 F31E8.5 F31E8.5 Putative paralog of C. elegans Y43F8A.B gene product F31E8.6 F31E8.6 Member of the ATP-dependent DNA topoisomerase II family, which catalyze the interconversion of topological DNA isomers, has moderate similarity to a region of DNA topoisomerase II beta (human TOP2B), which introduces double-stranded breaks DNA topoisomerase II; This gene encodes a protein predicted by Eisenberg and coworkers, with 68% accuracy, to be mitochondrial. F31E9.1 F31E9.1 Member of an uncharacterized protein family This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins; this gene's encoded protein also contains an FTH/DUF38 motif, which may also mediate protein-protein interaction. F31E9.2 F31E9.2 Protein with similarity to G protein-coupled receptors of the SRG subfamily, no homolog found in human or D. melanogaster G-protein coupled receptor, srg family F31E9.3 F31E9.3 Protein of unknown function, has moderate similarity to C. elegans F44G3.8 This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins; this gene's encoded protein also contains an FTH/DUF38 motif, which may also mediate protein-protein interaction. F31E9.4 F31E9.4 Protein of unknown function, has strong similarity to C. elegans Y44A6C.2 This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins. F31E9.5 F31E9.5 Protein containing a DUF216 domain of unknown function, has high similarity to uncharacterized C. elegans C18D4.7 F31E9.6 F31E9.6 Protein of unknown function, putative paralog of C. elegans C18D4.6 F31F4.1 F31F4.1 Member of an uncharacterized protein family F31F4.11 F31F4.11 Member of an uncharacterized protein family F31F4.12 F31F4.12 Protein containing a nuclear hormone receptor ligand-binding domain, has moderate similarity to C. elegans NHR-58, which a putative ligand-dependent nuclear receptor that functions in embryogenesis and morphogenesis zinc finger protein F31F4.13 F31F4.13 Protein containing a DUF215 domain of unknown function, has high similarity to uncharacterized C. elegans F31F4.14 7TM chemoreceptor, sru family F31F4.14 F31F4.14 Protein containing a DUF215 domain of unknown function, has high similarity to uncharacterized C. elegans F36G9.5 7TM chemoreceptor, sru family F31F4.15 F31F4.15 Protein containing a DUF38 domain of unknown function, has low similarity to C. elegans FOG-2, which is required for the sexual identity of germ cells F31F4.16 srj-5;F31F4.16 Member of the 7-transmembrane chemoreceptor family of G protein-coupled receptors (GPCR), has low similarity to C. elegans ODR-10, which is involved in odorant response 7TM chemoreceptor, srj family F31F4.17 F31F4.17 Member of an uncharacterized protein family F31F4.18 F31F4.18 Protein of unknown function, putative paralog of C. elegans F31F4.9 7TM chemoreceptor, srh family F31F4.2 F31F4.2 Putative G protein-coupled receptor, no homolog found in human or D. melanogaster 7TM chemoreceptor, srx family F31F4.3 F31F4.3 Putative G protein-coupled receptor, no homolog found in human or D. melanogaster 7TM chemoreceptor, srx family F31F4.4 F31F4.4 Putative G protein-coupled receptor, no homolog found in human or D. melanogaster 7TM chemoreceptor, srx family F31F4.5 F31F4.5 Protein of unknown function, has weak similarity to C. elegans C24G7.3 F31F4.6 F31F4.6 Member of the 7-transmembrane chemoreceptor family of G protein-coupled receptors (GPCR), has moderate similarity to uncharacterized C. elegans C54F6.1 7TM chemoreceptor, srh family F31F4.7 F31F4.7 Member of the UDP-glucuronosyltransferase protein family UDP glucuronosyltransferase F31F4.8 srj-6;F31F4.8 Member of the 7-transmembrane chemoreceptor family of G protein-coupled receptors (GPCR), has low similarity to C. elegans ODR-10, which is involved in odorant response 7TM chemoreceptor, srj family F31F4.9 F31F4.9 Member of the 7-transmembrane chemoreceptor family of G protein-coupled receptors (GPCR), has high similarity to uncharacterized C. elegans F31F4.18 7TM chemoreceptor, srh family F31F6.1 F31F6.1 Member of an uncharacterized protein family member of worm-specific protein family F31F6.2 F31F6.2 Protein of unknown function, has high similarity to uncharacterized C. elegans F31F6.3 member of worm-specific protein family F31F6.3 F31F6.3 Protein of unknown function, has low similarity to a region of C. elegans R06C7.8, which is required for meiotic progression in the germline member of worm-specific protein family F31F6.4 flp-8;F31F6.4 Putative FMRF-amide neurotransmitter flp-8 encodes three copies of a FMRFamide-related short peptide neurotransmitter; although the FLP-8 peptide can increase pharyngeal action potential frequency, loss of FLP-8 function does not result in a mutant phenotype, suggesting that FLP-8 may function redundantly with other FMRFamide-like peptides in the nervous system; FLP-8 expression is detected in embryos and larval stages, but not in adults; FLP-8 is expressed in the sensory neurons ASEL/R, URXL/R, and PVM. F31F6.5 ptr-7;F31F6.5 Member of the patched family, which are transmembrane receptors, has weak similarity to Niemann-Pick disease type C1 (human NPC1), which plays a role cholesterol transport, may mediate endocytosis, and is associated Niemann-Pick type C1 disease daf-6 is required for an unidentified function of the nonneuronal amphidial sheath cells that promotes correct morphology of both the amphid and the outer labial sensilla; daf-6 mutants disrupt the joining of the amphid sheath and socket cells to form the receptor channel, and display defects in several distinct functions including formation of dauer larvae, chemotaxis, osmotic avoidance, male mating, negative regulation of lifespan, negative regulation of ASJ's axonal growth late in development, and dye uptake by amphids and phasmids; daf-6 has recently been reported to be identical to the coding sequence ptr-7/F31F6.5, but this assertion has not yet been verified by transgenic rescue. F31F6.6 F31F6.6 Member of the Sodium:sulfate symporter family of membrane transporters, has moderate similarity to sodium-dependent dicarboxylate cotransporter (solute carrier family 13 member 2, rat Slc13a2), which reabsorbs Krebs cycle intermediates low-affinity decarboxylate transporter F31F6.7 F31F6.7 Member of the class 2 lipase family, has moderate similarity to uncharacterized C. elegans C09E8.2 lipase F31F7.1 F31F7.1 Member of an uncharacterized protein family F31F7.2 F31F7.2 Protein containing a von Willebrand factor (vWF) type A domain F31F7.3 F31F7.3 Protein of unknown function F32A11.1 F32A11.1 Member of the staphylococcal nuclease family F32A11.2 hpr-17;F32A11.2 Has similarity to S. pombe and human RAD17, cell cycle checkpoint proteins F32A11.3 F32A11.3 Protein required for spermatogenesis F32A11.4 F32A11.4 Member of the ATP-dependent DNA topoisomerase II family, contains a histidine kinase-like ATPase domain, has high similarity to a region of DNA topoisomerase II alpha (mouse Top2a), which is involved in DNA replication, transcription and drug resistance DNA topoisomerase II (N-terminal region); This gene encodes a protein predicted by Eisenberg and coworkers, with 52% accuracy, to be mitochondrial. F32A11.5 F32A11.5 Member of the ATP-dependent DNA topoisomerase II family, which catalyze the interconversion of topological DNA isomers, has high similarity to a region of DNA topoisomerase II alpha (human TOP2A), which plays diverse roles in DNA metabolism F32A11.6 F32A11.6 Protein with high similarity to C. elegans DAO-7, contains two CCCH-type zinc finger domains, which bind DNA or RNA Zinc finger C-x8-C-x5-C-x3-H type (and similar). F32A5.1 F32A5.1 Protein containing a Myb-like DNA-binding domain oxidoreductase F32A5.2 F32A5.2 Member of the animal heme peroxidase family, has a region of moderate similarity to a region of melanoma associated gene (human D2S448), which is a tumor antigen and possible peroxidase that may act in human TP53 dependent apoptosis and immune responses Peroxidase F32A5.3 F32A5.3 Member of the serine carboxypeptidase protein family; may be anchored to the membrane of a secretory vesicle or the Golgi apparatus Serine carboxypeptidase F32A5.4 F32A5.4 Protein of unknown function, has weak similarity to C. elegans R01E6.2 Immunodominant antigen F32A5.5 F32A5.5 Member of the major intrinsic protein (MIP) family, which are transmembrane channels, has moderate similarity to C. elegans AQP, which is a water channel F32A5.6 F32A5.6 Protein containing one Src homology 3 (SH3) domain, which bind proline-rich peptides, has moderate similarity to peroxisomal biogenesis factor 13 (human PEX13), which is associated with peroxisome biogenesis disorder complementation group H prx-13 is orthologous to the human gene PEX13 (OMIM:601789), which when mutated leads to Zellweger syndrome or neonatal adrenoleukodystrophy. F32A5.7 F32A5.7 Protein with high similarity to mouse Lsm4, which is implicated in peri-natal lethality in mice suggesting an important role in RNA splicing during development, member of the Sm family, which are core constituents of snRNP complexes U6 small nuclear RNA-associated Sm-like protein LSm4 F32A5.8 F32A5.8 Putative ortholog of C. elegans DC2.5 gene product F32A6.1 F32A6.1 Protein with weak similarity to C. elegans K08B12.5 F32A6.2 F32A6.2 Protein of unknown function F32A6.3 F32A6.3;cVPS41 Protein containing a clathrin and vacuolar protein sorting-associated (VPS) protein 7-fold repeat domain, has weak similarity to S. cerevisiae Vps41p, which is required for formation of AP-3 transport vesicles and the last step of vacuolar assembly F32A6.4 F32A6.4 Protein containing 12 TPR (tetratrico peptide repeat) domains and eight GoLoco motifs, which bind G-alpha proteins, has low similarity to activator of G protein signaling 3 (rat Ags3) ags-3 encodes an ortholog of mammalian AGS3, a receptor independent activator of G protein signalling, and of Drosophila RAPSYNOID; AGS-3 proteins have four GoLoco motifs; AGS-3 is involved in polarity and spindle orientation during early embryogenesis; a region of AGS-3 encompassing three GoLoco motifs specifically binds GOA-1 in yeast two-hybrid assays; AGS-3 is expressed in all muscles, intestine, and weakly in some head and ventral nerve cord neurons, with subcellular localization in strong dots. F32A6.5 sto-2;F32A6.5 Protein with high similarity to C. elegans UNC-1, which plays a role in chemosensory perception, locomotory behavior, and developmental processes, member of the SPFH domain or Band 7 family, which may regulate cation conductance F32A7.1 F32A7.1 Protein of unknown function, has high similarity to uncharacterized C. elegans K04F1.4 F32A7.2 F32A7.2 Protein of unknown function, has high similarity to uncharacterized C. elegans K04F1.4, which is predicted to be a G protein-coupled receptor 7TM chemoreceptor, srw family F32A7.3 F32A7.3 Protein containing two galactose binding lectin (SUEL-type lectin) domains, has a region of low similarity to a region of latrophilin (rat Cirl), which is a synaptic receptor for alpha-latrotoxin and stimulates exocytosis of small synaptic vesicles G-protein coupled receptor F32A7.4 F32A7.4 Protein of unknown function F32A7.5 F32A7.5 Protein of unknown function, has strong similarity to uncharacterized C. elegans F25D7.4 claustrin like F32A7.6 aex-5;F32A7.6 Member of the subtilase family of serine proteases, contains a proprotein convertase P-domain, has low similarity to prohormone convertase 1 (rat Pcsk1), which is a serine proteinase involved in the maturation of hormones neuroendocrine convertase 2 precursor like; an ortholog of calcium-dependent serine endoproteinases, the kex2/subtilisin-like proprotein convertase that affects defecation cycle and anterior body contractions; and is expressed in all muscle cells except pharyngeal muscles. F32A7.7 F32A7.7 Member of the 7-transmembrane chemoreceptor family of G protein-coupled receptors (GPCR), has moderate similarity to uncharacterized C. elegans C06B3.9 F32B4.1 F32B4.1 Protein containing a DUF235 domain of unknown function, has low similarity to uncharacterized C. elegans F22E5.1 F32B4.2 F32B4.2 Protein of unknown function, has weak similarity to C. elegans F23H12.2 F32B4.4 F32B4.4 Protein containing an RNA recognition motif (RRM, RBD, or RNP) RNA recognition motif. (aka RRM, RBD, or RNP domain) F32B4.5 F32B4.5 Protein of unknown function, has weak similarity to C. elegans Y19D2A.B F32B4.6 F32B4.6 Member of the alpha or beta hydrolase fold family, has moderate similarity to uncharacterized C. elegans R05D7.4 alpha/beta hydrolase fold F32B4.7 F32B4.7 Protein of unknown function F32B4.8 F32B4.8 Protein containing two PAN domains, which may mediate protein-protein or protein-carbohydrate interactions F32B5.1 F32B5.1 Member of the arginine kinase, phosphotransferase protein family phosphotransferase F32B5.2 F32B5.2 Protein of unknown function F32B5.3 F32B5.3 Protein of unknown function, has high similarity to uncharacterized C. elegans K04A8.1 F32B5.4 F32B5.4 Protein of unknown function, predicted to contain a glycosylphosphatidylinositol (GPI) lipid anchor F32B5.6 F32B5.6 Protein of unknown function F32B5.7 F32B5.7 Protein of unknown function F32B5.8 F32B5.8 Member of the papain family of cysteine proteases, has a region of high similarity to cathepsin Z (cathepsin Y, rat Ctsz), which is a cysteine (thiol) protease that participates in protein processing cysteine proteinase F32B6.1 nhr-4;F32B6.1 Member of the nuclear hormone receptor, C4-type zinc finger protein family Ligand-binding domain of nuclear hormone receptors, Zinc finger, C4 type (two domains) F32B6.10 F32B6.10 Protein of unknown function, similar to serine/threonine kinases serine/threonine kinase F32B6.11 F32B6.11 Protein of Unknown Function F32B6.2 F32B6.2 Protein with high similarity to human MCCC1, which plays a role in leucine catabolism, contains carbamoyl-phosphate synthase L chain ATP binding and N terminal domains, a biotin carboxylase C-terminal domain, and a biotin or lipoyl attachment domain carbomoyl-phosphate carboxylase; The F32B6.2 gene encodes an ortholog of the human gene ALPHA METHYLCROTONOYL-COENZYME A CARBOXYLASE 1 (MCCC1; 3-MCC), which when mutated leads to beta-methylcrotonyl-glycinuria (OMIM:210200); the F32B6.2 protein is predicted to be mitochondrial with 52% accuracy. F32B6.3 F32B6.3 Protein containing a splicing factor Prp18 domain, has moderate similarity to pre-mRNA processing factor 18 (human PRP18), which is a component of the U4-U6 U5 snRNP particles and is required for the second catalytic step of pre-mRNA splicing Human HPRP18 protein like F32B6.4 F32B6.4 Protein of unknown function, has high similarity to uncharacterized C. elegans C16A11.7 F32B6.5 F32B6.5 Protein of unknown function, has high similarity to uncharacterized C. elegans T13F2.9 F32B6.6 msp-77;F32B6.6 Member of the major sperm-specific protein (MSP) family major sperm protein; msp-77 encodes a protein that belongs to a family of proteins called the Major Sperm Proteins (MSPs) that is conserved in nematodes; this family consists of closely related, small, basic proteins that make up 15% of sperm protein; this multigene family consists of over fifty genes, including many pseudogenes; MSPs are involved in both extracellular signaling and cytoskeletal functions during reproduction-MSP antagonizes Eph/ephrin signaling, in part, by binding VAB-1 Eph receptor tyrosine kinase on oocytes and sheath cells to promote oocyte maturation and MAPK activation; MSPs assemble into fibrous networks that drive movement of the C. elegans sperm; msp genes are expressed only in late primary spermatocytes. F32B6.7 F32B6.7 Protein containing a major sperm protein (MSP) domain, which are involved in sperm motility, has very strong similarity to uncharacterized C. elegans T13F2.12 F32B6.8 F32B6.8 Putative ortholog of S. cerevisiae Gyp1p, a GTPase-activating protein involved in vesicular transport Yeast ORF YOR070C protein like F32B6.9 F32B6.9 Member of the C. elegans putative membrane protein family 8, has moderate similarity to a region of bestrophin (human VMD2), which plays a role in vision and is associated with Bests disease, adult vitelliform macular dystrophy, and bull's eye maculopathy Putative membrane protein F32D1.1 F32D1.1 Member of the proteasome complex protein family ATPase F32D1.10 F32D1.10 Protein with high similarity to minichromosome maintenance deficient 7 (mouse Mcmd7), which forms a DNA dependent ATP dependent DNA helicase likely to be involved in DNA replication, member of the MCM family of DNA-dependent ATPases cell division control protein F32D1.2 F32D1.2 Protein of unknown function, has high similarity to uncharacterized C. elegans R05D3.6 ATP synthase epsilion chain F32D1.3 F32D1.3 Protein containing eight TPR (tetratrico peptide repeat) domains, which may mediate protein-protein interactions, has low similarity to uncharacterized C. elegans F38B6.6 F32D1.4 F32D1.4 Protein of unknown function containing a Ground-like domain, has weak similarity to C. elegans K03B8.7 F32D1.5 F32D1.5 Member of the inosine-5'-monophosphate dehydrogenase protein family GMP reductase F32D1.6 F32D1.6 Protein of unknown function F32D1.7 F32D1.7 Protein of unknown function F32D1.8 F32D1.8 Protein of unknown function F32D1.9 F32D1.9 Protein of unknown function, has a region of low similarity to S. cerevisiae Fip1p, which is a component of a polyadenylation factor that interacts with poly(A) polymerase F32D8.1 F32D8.1 Protein containing a protein kinase domain, has low similarity to CamKI-like protein kinase (human LOC57118), which is a granulocyte-specific protein kinase that is stimulated by interleukin 8 (human IL8) and activates ERK/MAP kinase activity calcium/calmodulin dependent protein kinase F32D8.10 F32D8.10 G protein-coupled receptor of unknown function, no homolog found in human or D. melanogaster F32D8.11 F32D8.11 Protein of unknown function F32D8.2 F32D8.2 Protein of unknown function, has moderate similarity to uncharacterized C. elegans F32G8.2 F32D8.3 F32D8.3 Protein containing a trypsin inhibitor-like cysteine rich domain F32D8.4 F32D8.4 Member of the D-lactate dehydrogenase protein family lactate dehydrogenase; F32D8.4 is homologous to Yip1p, an essential Golgi membrane protein in S. cerevisiae that specifically binds the transport GTPases Ypt1p and Ypt31p, as well as Yop1p (the yeast homolog of human ADENOMATOUS POLYPOSIS COLI 1); F32D8.4 is also homologous to the Golgi membrane protein SB140 of H. sapiens, and contains a glutamine/asparagine-rich domain. F32D8.5 F32D8.5 Protein of unknown function F32D8.6 emo-1;F32D8.6 Member of the SecE-Sec61-gamma subunits of protein translocation complex family, has strong similarity to uncharacterized human SEC61G protein transport protein SEC61 gamma subunit; emo-1 encodes an ortholog of S. cerevisiae Sec61p gamma subunit, which is required for translocation of secreted and membrane proteins into the endoplasmic reticulum; EMO-1 is required for oogenesis and ovulation. F32D8.7 F32D8.7 Protein of unknown function Kunitz/Bovine pancreatic trypsin inhibitor domain F32D8.8 F32D8.8 Protein of unknown function, has moderate similarity to uncharacterized C. elegans K04A8.1 F32D8.9 F32D8.9 Protein of unknown function F32E10.1 F32E10.1 Putative ortholog of S. cerevisiae Ygr145p, a protein of unknown function F32E10.2 F32E10.2 Protein containing a Chromo domain, which bind chromatin, has moderate similarity to uncharacterized C. elegans F32E10.6 chromo domain of heterochromatin protein F32E10.3 F32E10.3 Coiled-coil protein containing two N-terminal low-density lipoprotein receptor class A domains and a C-type lectin domain LDL-receptor ligand-binding repeat F32E10.4 ima-3;F32E10.4 Member of the karyopherin-alpha protein family, important in germ line and other development importin alpha, nuclear transport factor F32E10.5 F32E10.5 Protein containing a tudor domain, which are found in proteins involved in RNA localization F32E10.6 F32E10.6 Protein containing a Chromo domain, which bind chromatin, has moderate similarity to uncharacterized C. elegans F32E10.2 F32E10.7 F32E10.7 Protein of unknown function F32E10.8 F32E10.8 Protein with weak similarity to C. elegans T21E3.3 gene product F32F2.1 F32F2.1 Protein containing a RhoGEF (GTPase exchange factor) domain, has a region of low similarity to a region of triple functional domain (human TRIO), which is a RAC and RHO guanine nucleotide exchange factor Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases F32G8.1 F32G8.1 Protein of unknown function, has low similarity to uncharacterized C. elegans F13G3.2 F32G8.2 F32G8.2 Protein of unknown function, putative paralog of C. elegans F32D8.2 F32G8.3 F32G8.3 Protein of unknown function F32G8.4 F32G8.4 Member of the C. elegans putative membrane protein family 8, has low similarity to a region of bestrophin (human VMD2), which plays a role in vision and is associated with Bests disease, adult vitelliform macular dystrophy, and bull's eye maculopathy Putative membrane protein F32G8.5 F32G8.5 Protein containing two collagen triple helix repeats and one nematode cuticle collagen N-terminal domain, has low similarity to C. elegans DPY-16, which is a putative collagen involved in morphogenesis of an epithelium collagen F32G8.6 F32G8.6 Protein with high similarity to GTP cyclohydrolase I (rat Rn.28195/Gch), which is involved in tetrahydrobiopterin synthesis, member of the GTP cyclohydrolase I family, which are involved in formic acid and dihydroneopterin triphosphate biosynthesis GTP cyclohydrolase I; cat-4 encodes an ortholog of the human GTP cyclohydrolase I gene (GCH1; OMIM:600225), which when mutated leads to dystonia; CAT-4 is involved in serotonin and dopamine biosynthesis that affects movement, mating behavior, foraging behavior, and cell migration; CAT-4 acts in the same genetic pathway as flp-1. F32H2.1 F32H2.1 Protein containing six Myb-like DNA-binding domains, has a region of low similarity to a region of small nuclear RNA activating complex polypeptide 4 190 kDa (human SNAPC4), which is required for snRNA gene transcription by RNA polymerase II and III protooncogene C-MYB like; gei-11 encodes a protein that contains Myb DNA-binding domains and is homologous to mammalian SNAPC4, required for RNA polymerase II and III transcription of snRNA genes; GEI-11 is required for ventral enclosure during embryonic development, as well as for normal rates of postembryonic growth; GEI-11 interacts with GEX-3, a homolog of mammalian protein ligands of the small GTPase Rac1 that is also essential for embryonic morphogenesis. F32H2.10 F32H2.10 Protein of unknown function F32H2.2 F32H2.2 Protein of unknown function, has a region of high similarity to a region of S. cerevisiae Soh1p, which is a protein that allows hpr1 null mutant to grow at 37 deg Yeast SOH1 protein like F32H2.3 F32H2.3 Protein of unknown function spd-2 encodes a protein with three predicted coiled-coil domains; SPD-2 activity is essential for centrosome maturation and duplication, and hence for proper mitotic spindle assembly; in regulating the early steps of centrosome maturation, SPD-2 acts together with the coiled-coil protein SPD-5, the Aurora-A kinase AIR-1, and the cytoplasmic dynein DHC-1; in regulating centrosome duplication, SPD-2 likely acts together with the ZYG-1 kinase; in both processes, SPD-2 may function to recruit centrosomal components such as ZYG-9 and microtubule-nucleating gamma-tubulin complexes to the developing centrosome; within centrosomes, SPD-2 localizes to both centrioles and the pericentriolar material; efficient centrosomal localization depends upon AIR-1 and DHC-1, while localization specifically to the pericentriolar material depends upon SPD-5. F32H2.4 F32H2.4 Protein containing three WD domains (WD-40 repeat), which may mediate protein-protein interactions, has weak similarity to a region of transducin (beta)-like 1 (human TBL1), which binds histone H3 and may be associated with vision and hearing disorders WD domain, G-beta repeat (3 domains) F32H2.5 F32H2.5 Predicted fatty acid synthase fatty acid synthase; This gene encodes a protein predicted by Eisenberg and coworkers, with 68% accuracy, to be mitochondrial. F32H2.6 F32H2.6 Protein containing a beta-ketoacyl synthase N-terminal domain, which are involved in dimer formation, has moderate similarity to a region of fatty acid synthase (rat Fasn), which is a multifunctional enzyme with beta-ketoacyl synthase and other activities fatty acid synthase (N-terminus) F32H2.7 F32H2.7 Protein of unknown function F32H2.8 F32H2.8 Protein of unknown function, has moderate similarity to uncharacterized C. elegans ZK1055.2 glycosyltransferase F32H2.9 tba-6;F32H2.9 Protein with high similarity to alpha tubulin (C. elegans MEC-12), which is required in mechanosensory neurons, member of the tubulin-FtzA family, which are involved in polymer formation tubulin alpha chain F32H5.1 F32H5.1 Member of the papain family of cysteine proteases, has moderate similarity to cathepsin B (mouse Ctsb), which is a cysteine (thiol) protease that degrades cartilage matrix proteins and contributes to TNF alpha mediated apoptosis cathepsin B like cysteine protease F32H5.2 F32H5.2 Member of the ion transport family, which include calcium, sodium, and potassium channels, has a region of weak similarity to a region of potassium channel subfamily K member 3 (TASK-1) (mouse Kcnk3) F32H5.3 F32H5.3 Protein of unknown function F32H5.4 F32H5.4 Member of the sugar (and other) transporter family, has low similarity to human SLC22A5, which is a sodium-dependent carnitine transporter that provides carnitine for fatty acid beta-oxidation transport protein F32H5.5 F32H5.5 Protein with moderate similarity to C. elegans T02B11.1 gene product G-protein coupled receptor, srg family F32H5.6 F32H5.6 Protein of unknown function, has moderate similarity to uncharacterized C. elegans F09F3.12 7TM receptor, srx family F33A8.1 let-858;F33A8.1 Prototypical nucampholin that associates with chromatin in adult germline cells and is necessary for germline proliferation during development let-858 encodes nucampholin, a highly conserved protein rich in acidic and basic residues that also shares some similarity to eukaryotic initiation factor eIF-4 gamma; LET-858 is required for early embryogenesis and tissue differentiation and is expressed ubiquitously throughout development; LET-858 localizes to nuclei where it overlaps, but is not restricted to, chromosomal regions; based upon its sequence and localization, LET-858 is likely to be involved in protein synthesis and/or RNA binding. F33A8.2 F33A8.2 FAFA neurotransmitter nlp-18 encodes four predicted neuropeptide-like proteins; in C. elegans, nlp-18 is part of the FAFA neuropeptide family that also contains nlp-20; nlp-18 is expressed in a variety of neurons, including ASI, NSM, four head neurons, two tail neurons, and two anterior pharyngeal neurons; nlp-18 expression is also detected in the spermatheca, the rectal gland, and the intestine; as loss of nlp-18 activity via large-scale RNAi screens does not result in any obvious abnormalities, the precise role of nlp-18-encoded peptides in development and/or behavior is not yet known. F33A8.3 F33A8.3 Protein containing a cold-shock nucleic acid binding domain, which bind both single-stranded DNA and single-stranded RNA, has high similarity to a region of muscle Y-box protein YB2 (rat YB2), which is a transcriptional repressor 'Cold-shock' DNA-binding domain; cey-1 encodes a protein with a cold-shock/Y-box domain that is expressed in early embryonic blastomeres (at the 15-cell stage, i.e., pre-gastrulation), but is normally repressed in early germline blastomeres by PIE-1; it is predicted to be mitochondrial by phylogenetic profiling. F33A8.4 F33A8.4 Protein of unknown function F33A8.5 F33A8.5 Protein with similarity across the middle region to human SDHD (succinate dehydrogenase complex, subunit D, integral membrane protein) F33A8.5 is orthologous to the human gene SUCCINATE DEHYDROGENASE COMPLEX, SUBUNIT D, INTEGRAL MEMBRANE PROTEIN (SDHD; OMIM:602690), which when mutated leads to disease. F33A8.6 F33A8.6 Member of the protein phosphatase 2C family, which are Mg2+ dependent protein serine and threonine phosphatases, has moderate similarity to a region of rat AF095927, which is a serine-threonine protein phosphatase involved in regulation of cell cycle Protein phosphatase 2C F33A8.7 F33A8.7 Protein of unknown function F33A8.9 F33A8.9 Protein with strong similarity to C. elegans F38A3.1 (Putative collagen, protein with strong similarity to human COL5A2 protein, alpha-2 collagen, type V) collagen F33C8.1 F33C8.1 Protein containing six Kelch motif domains, four plexin repeats, a CUB domain, and two laminin epidermal growth factor (EGF)-like domains, has low similarity to attractin (rat Atrn), which is involved in myelination of the central nervous system perlecan like glycoprotein; tag-53 encodes a protein with high similarity to human Attractin, and affects fertility and locomotion. F33C8.2 F33C8.2 Protein of unknown function, has moderate similarity to C. elegans Y49F6C.C F33C8.3 F33C8.3 Member of the tetraspanin family, which contain an N-terminal transmembrane domain that is a signal sequence and membrane anchor, has low similarity to kangai 1 (human KAI1), which is a T cell activation antigen that plays a role in cancer progression tetraspanin; tsp-8 is orthologous to the human gene KANGAI 1 (SUPPRESSION OF TUMORIGENICITY 6, PROSTATE; CD82 ANTIGEN (R2 LEUKOCYTE ANTIGEN, ANTIGEN DETECTED BY MONOCLONAL AND ANTIBODY IA4)) (KAI1; OMIM:600623), which when mutated leads to disease. F33C8.4 F33C8.4 Protein with weak similarity to C. elegans hch-1 (Putative zinc-dependent metalloprotease, putative paralog of C. elegans K04E7.3, a member of the CUB domain protein family) F33D11.1 F33D11.1 Protein containing two LIM domains, which may mediate protein-protein interactions, has low similarity to a region of Z-band alternatively spliced PDZ-motif protein (human LDB3), which is a Z-band component with many isoforms LIM protein F33D11.10 F33D11.10 Protein with high similarity to human EIF4A1, which is a subunit of eIF4F and an ATP dependent RNA helicase required for translation, member of the DEAD or DEAH box ATP-dependent RNA helicase family and contains a helicase conserved C-terminal domain intiation factor/helicase F33D11.11 F33D11.11 Protein with weak similarity to members of the major sperm-specific protein (MSP) family, longer than typical MSP proteins, has similarity to human vesicle-associated proteins VAPB and VAPA, has similarity to cytosolic region of S. cerevisiae Scs2p ER membrane protein F33D11.12 F33D11.12 Protein with strong similarity to C. elegans C17D12.1 gene product F33D11.2 F33D11.2 Protein of unknown function, has moderate similarity to uncharacterized C. elegans T09A12.1 F33D11.3 F33D11.3 Protein containing two collagen triple helix repeats, which are found in some extracellular proteins, and a nematode cuticle collagen N-terminal domain, has a region of high similarity to a region of C. elegans BLI-1 collagen F33D11.4 ceh-12;F33D11.4 Protein containing a homeobox domain (homeodomain), which are found in transcription factors, has low similarity to C. elegans MSX-1, which is a homeodomain transcription factor homeobox protein; ceh-12 is orthologous to the human gene HB9 HOMEOBOX PROTEIN (HLXB9; OMIM:142994), which when mutated leads to disease. F33D11.5 F33D11.5 Protein of unknown function, has weak similarity to uncharacterized C. elegans N2P17 F33D11.6 F33D11.6 Protein of unknown function, has weak similarity to C. elegans B0228.9 F33D11.7 F33D11.7 Protein with low similarity to C. elegans Y106G6E.6, which is a serine/threonine protein kinase protein kinase F33D11.8 F33D11.8 Protein of unknown function F33D11.9 F33D11.9 Protein with weak similarity to glycosylphosphatidylinositol anchor attachment 1 (GPI anchor attachment protein 1, human GPAA1), which is a component of GPI transamidase complex that attaches glycosylphosphatidylinositol anchors to proteins F33D4.1 nhr-8;F33D4.1 Has moderate similarity to C. elegans DAF-12 which is similar to nuclear hormone receptors zinc finger protein/hormone receptor; The nhr-8 gene encodes a nuclear hormone receptor homolog; nhr-8(ok186) mutants have abnormally low resistance to the toxins colchicine and chloroquine. F33D4.2 dec-4;itr-1;lfe-1;F33D4.2 Putative inositol (1,4,5) trisphosphate receptor which regulates defecation cycle timing, possibly through regulation of intestinal calcium fluxes inositol 1,4,5-triphosphate receptor; itr-1 encodes a putative inositol (1,4,5) trisphosphate receptor that affects the defecation cycle and pharyngeal pumping, and also affects ovulation in a pathway downstream of LET-23; interacts with UNC-54 in vivo, and is expressed in the adult intestine, pharynx, excretory cell, germ line, and spermatheca, with limited neuronal expression. F33D4.3 flp-13;FaRP_II;F33D4.3 Protein containing AADGAPLIRF-amide neuromodulator F33D4.4 F33D4.4 Protein with high similarity to degenerative spermatocyte homolog (human DEGS), which regulates the biosynthesis of the epidermal growth factor receptor (EGFR) F33D4.5 F33D4.5 Member of the ribosomal L1p or L10e family, which are part of the large ribosomal subunit and may be involved in RNA binding F33D4.6 F33D4.6 Putative ortholog of C. elegans F33D4.6A gene product F33D4.7 F33D4.7 Protein of unknown function F33E11.1 nhr-15;F33E11.1 Member of the nuclear hormone receptor/Zinc finger protein family nuclear hormone receptor; nhr-15 is predicted to encode a member of the nuclear hormone receptor family. F33E11.2 F33E11.2 Protein of unknown function F33E11.3 F33E11.3 Protein contains putative PHD zinc finger domains, has similarity to a region of human REQ, requiem, apoptosis response zinc finger protein F33E11.5 F33E11.5 Protein with moderate similarity to C. elegans C28H8.9 gene product F33E11.6 F33E11.6 Protein of unknown function F33E2.2 F33E2.2 Protein containing a protein kinase domain, has low similarity to mitogen activated protein kinase kinase kinase 13 (leucine zipper bearing kinase, human MAP3K13), which induces phosphorylation of c-Jun (human JUN) and activation of JNK-1 (human PRKM8) Eukaryotic protein kinase domain; dlk-1 encodes a homolog of mammalian mitogen-activated protein kinase kinase kinase 12; DLK-1 is dispensable for embryonic development and gross morphology in mass RNAi screens. F33E2.3 F33E2.3 Protein containing a C-type lectin domain, which mediate calcium-dependent carbohydrate recognition Lectin C-type domain F33E2.4 F33E2.4 Protein of unknown function F33E2.5 F33E2.5 Protein of unknown function, has weak similarity to C. elegans F33E2.3 F33E2.6 F33E2.6 Protein of unknown function, has a region of low similarity to a region of nascent-polypeptide-associated complex alpha subunit (mouse Naca), which binds JUN, enhances JUN-mediated transcription, and functions in myogenesis F33G12.2 F33G12.2 Protein containing seven WD domains (WD-40 repeat), which may mediate protein-protein interactions, has low similarity to human HPRP8BP, which is a U5 snRNP-specific protein and a component of the U5 small nuclear ribonucleoprotein particle F33G12.3 F33G12.3 Protein of unknown function F33G12.4 F33G12.4 Protein containing four leucine rich repeats, which mediate protein-protein interactions F33G12.5 F33G12.5 Putative coiled-coil protein, has similarity to human centromere protein CENPE F33G12.6 F33G12.6 Protein of unknown function F33H1.1 daf-19;daf-24;RFXC.e;F33H1.1 RFX-type transcription factor that is specific to sensory neurons DNA binding transcription factor F33H1.2 gpd-4;F33H1.2 Glyceraldehyde-3-phosphate dehydrogenase glyceraldehyde 3-phosphate dehydrogenase 4; gpd-4 encodes one of four C. elegans glyceraldehyde-3-phosphate dehydrogenases (GAPDHs); by homology, GPD-4 is predicted to reversibly catalyze the oxidation and phosphorylation of glyceraldehyde-3-phosphate to 1,3-diphosphoglycerate during glycolysis; GPD-4 is required for embryonic and larval development; in C. elegans, GPD-4 and GPD-1 constitute the minor GAPDH isoenzymes and are expressed primarily in embryos, in all cell types. F33H1.3 F33H1.3 Protein of unknown function F33H1.4 F33H1.4 Protein of unknown function F33H1.5 srd-1;F33H1.5 G protein-coupled receptor, expressed in chemosensory neurons, no homolog found in human or D. melanogaster srd-1 encodes a seven transmembrane chemosensory receptor; SRD-1 is expressed in the ASI chemosensory neurons; SRD-1 expression in ASI is repressed in the presence of dauer pheromone at concentrations lower than that which induces dauer formation. F33H12.2 sri-39;F33H12.2 Member of the 7-transmembrane chemoreceptor family of G protein-coupled receptors (GPCR), has very strong similarity to uncharacterized C. elegans D2062.8 7TM chemoreceptor, sri family F33H12.4 sri-74;F33H12.4 Member of the 7-transmembrane chemoreceptor family of G protein-coupled receptors (GPCR), has high similarity to uncharacterized C. elegans D2062.9 7TM chemoreceptor, sri family F33H12.5 sri-36;F33H12.5 Member of the 7-transmembrane chemoreceptor family of G protein-coupled receptors (GPCR), has moderate similarity to uncharacterized C. elegans F11A5.11 7TM chemoreceptor, sri family F33H2.2 F33H2.2 Protein of unknown function F33H2.3 F33H2.3 Protein with moderate similarity to human ANP32B, which is an acidic protein rich in leucines that binds to RNA polymerase I and may have a role in the regulation of ribosomal RNA synthesis Leucine Rich Repeat (2 copies) (2 domains) F33H2.5 F33H2.5 Protein containing a DNA polymerase B exonuclease domain, which have 3' to 5' exonuclease activity and adopt a ribonuclease H type fold, has moderate similarity to DNA polymerase epsilon 1 (human POLE), which is the catalytic subunit of a DNA polymerase DNA polymerase family B (3 domains) F33H2.6 F33H2.6 Protein of unknown function F33H2.7 F33H2.7 Protein containing an MYND finger domain, has weak similarity to uncharacterized C. elegans R06F6.4 F33H2.8 F33H2.8 Protein of unknown function F34D10.2 F34D10.2 Member of the CDC45p family, which may be involved in DNA replication, has a region of low similarity to cell division cycle 45 like (human CDC45L), which may function in DNA replication initiation and is implicated in DiGeorge syndrome upon gene deletion F34D10.3 F34D10.3 Protein of unknown function F34D10.4 F34D10.4 Putative ortholog of C. elegans Y20F4.6 gene product F34D10.5 lin-48;F34D10.5 Putative transcription factor, regulates hindgut cell lineage Zinc finger, C2H2 type (3 domains); lin-48 encodes a C2H2-type zinc-finger transcription factor that is orthologous to Drosophila OVO and mouse OVO1; LIN-48 is required for development of the hindgut, the male tail, and the excretory duct cell; in hindgut and male tail development, LIN-48 activity is essential for proper fate specification of the U, F, and K' blast cells and B blast cell descendants, and in excretory duct cell development, for normal duct cell morphogenesis; a LIN-48 translational reporter is expressed in the nuclei of the U, F, K, and K' blast cells, the excretory duct cell, and up to 10 cells in the head region beginning in late embryogenesis and continuing through adulthood; in addition, expression is detected in the neuronal support cells of the phasmid and labial sensory structures beginning at the late L1 larval stage; in hindgut cell specification, LIN-48 functions with EGL-38/Pax, which appears to be a direct transcriptional regulator of LIN-48 expression, and in excretory duct cell development, LIN-48 is likely under the control of the CES-2 bZip transcription factor. F34D10.6 F34D10.6 Protein containing thirteen ankyrin (Ank) repeats, which may mediate protein-protein interactions, has a region of low similarity to a region of tankyrase (human TNKS), which has poly(ADP-ribose) polymerase activity and functions in telomere maintenance 7 ANK repeats F34D6.1 F34D6.1 Protein containing an F-box domain, which serve as a link between a target protein and a ubiquitin-conjugating enzym This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins. F34D6.2 F34D6.2 Homeodomain transcription factor, has weak similarity to C. elegans LIM-7 homeobox protein F34D6.3 twk-23;F34D6.3 Protein with high similarity to tandem pore domain acid sensitive K+ channel 3 (TASK-3) (human KCNK9), which mediates a K+-selective background conductance that is inhibited by acidic extracellular pH, member of the ion transport family sup-9 encodes one of 44 C. elegans TWK (two-P domain K+) potassium channel subunits that contain two pore-forming domains and four transmembrane domains; sup-9 was originally defined by gain-of-function mutations that result in defects in pharyngeal, body-wall, egg-laying, and enteric muscle activation; loss of sup-9 function via reversion or RNA-mediated interference (RNAi) does not result in any abnormalities suggesting that SUP-9 may function redundantly with other TWK channels; SUP-9 is expressed in neurons and muscle. F34D6.4 F34D6.4 Protein containing a SET domain, which are involved in protein-protein interactions, has a region of moderate similarity to a region of suppressor variegation 3-9 homolog 1 (human SUV39H1), which methylates lysine 9 of histone H3 F34D6.5 F34D6.5 Member of the 7-transmembrane chemoreceptor family of G protein-coupled receptors (GPCR), has high similarity to uncharacterized C. elegans F34D6.6 7TM chemoreceptor, sri family F34D6.6 F34D6.6 Putative ortholog of C. elegans F34D6.5 gene product 7TM chemoreceptor, sri family F34H10.1 F34H10.1 Protein of unknown function, has high similarity to uncharacterized C. elegans K08C9.7 ubiquitin/ribosomal protein F34H10.2 F34H10.2 Protein of unknown function F34H10.3 F34H10.3 Protein of unknown function protein S10 F34H10.4 F34H10.4 Protein of unknown function F35A5.1 F35A5.1 Protein of unknown function, has low similarity to a region of proteoglycan 4 (megakaryocyte stimulating factor, human PRG4), which is a secreted proteoglycan with possible roles in regulating cell proliferation, ossification and joint lubrication The F35A5.1 gene encodes a homolog of human FMR2, which when mutated leads to fragile site mental retardation, type 2 (OMIM:309548). F35A5.2 F35A5.2 Protein of unknown function F35A5.3 F35A5.3 Protein of unknown function, has low similarity to a region of notch homolog 4 (human NOTCH4), which is a transmembrane receptor involved in cell proliferation and developmental processes and associated with CADASIL and various cancers when mutated abu-10 encodes a transmembrane protein with a predicted signal sequence, a glutamine/asparagine-rich domain and a cysteine-rich repeat (DUF139); abu-10 expression is induced by blockage of the unfolded-protein response in the endoplasmic reticulum (ER), and ABU-10 may function within the ER to protect the organism from damage by improperly folded nascent protein. F35A5.4 F35A5.4 Protein containing eight uncharacterized DUF139 cysteine repeat domains, has low similarity to uncharacterized C. elegans Y105C5.E F35A5.5 F35A5.5 Protein of unknown function F35A5.8 F35A5.8 Protein with high similarity to human SH3GLB1, which is involved in apoptosis, contains one Src homology 3 (SH3) domain, which bind proline-rich peptides erp-1 is homologous to the human gene endophilin B1 (also called SH3GLB1, for SH3 domain GRB2-like endophilin B1). F35B12.1 F35B12.1 Putative ortholog of C. elegans H12C20.5 gene product 7TM receptor, srx family F35B12.2 F35B12.2 Putative retinol dehydrogenase retinol dehydrogenase like; dhs-20 encodes a short-chain dehydrogenase predicted to be mitochondrial. F35B12.3 F35B12.3 Protein of unknown function F35B12.4 F35B12.4 Protein containing two kunitz or bovine pancreatic trypsin inhibitor domains, has moderate similarity to uncharacterized C. elegans T21D12.12 serine protease inhibitor F35B12.5 F35B12.5 Protein of unknown function F35B12.6 F35B12.6 Protein with similarity to serine protease inhibitor-like proteins, has strong similarity to C. elegans F35B12.4 serine protease inhibitor F35B12.7 F35B12.7 YGGWamide neurotransmitter F35B12.8 F35B12.8 Protein of unknown function Globin F35B3.1 F35B3.1 Protein of unknown function F35B3.2 F35B3.2 Member of the transposase family, which are required for excising and inserting mobile genetic elements, has very strong similarity to uncharacterized C. elegans F35B3.6 transposase F35B3.3 F35B3.3 Protein of unknown function F35B3.4 F35B3.4 Protein containing a DB module domain, has high similarity to uncharacterized C. elegans C42D4.3 F35B3.5 F35B3.5 Protein of unknown function The protein product of this gene is predicted to contain a glutamine/asparagine (Q/N)-rich ('prion') domain, by the algorithm of Michelitsch and Weissman (as of the WS77 release of WormBase, i.e., in wormpep77). F35B3.6 F35B3.6 Member of the transposase family, which are required for excising and inserting mobile genetic elements, has very strong similarity to uncharacterized C. elegans F35B3.2 transposase F35B3.7 F35B3.7 Protein of unknown function, contains a putative coiled-coil domain, has weak similarity in the C-terminus to human KIAA0552 protein F35C11.1 F35C11.1 MGL/Famide neurotransmitter F35C11.2 F35C11.2 Member of the protein-tyrosine phosphatase family, which are involved in control of cell growth, proliferation, differentiation and transformation, has a region of low similarity to a region of human PTPRG, which is a protein tyrosine phosphatase protein-tyrosine phosphatase F35C11.3 F35C11.3 Protein containing a protein kinase domain, has low similarity to casein kinase 1 delta (human CSNK1D), which is a serine/threonine protein kinase involved in DNA repair that may play a role in circadian rhythms and is elevated in Alzheimer's serine/threonine kinase F35C11.4 F35C11.4 Protein of unknown function F35C11.5 F35C11.5 Protein with moderate similarity to C. elegans C31H1.5 gene product phospholipase A2 F35C11.6 F35C11.6 Protein of unknown function F35C12.1 F35C12.1 Protein of unknown function F35C12.2 F35C12.2;CeNCKX Potassium dependent Na/Ca exchanger and may be an ortholog of the mammalian retinal rod potassium dependent Na/Ca exchanger Na/Ca,K exchanger F35C12.3 F35C12.3 Protein with strong similarity to C. elegans T23F6.2 gene product F35C5.1 F35C5.1 Protein of unknown function, has high similarity to uncharacterized C. elegans W01B6. F35C5.10 F35C5.10 Protein of unknown function, has high similarity to uncharacterized C. elegans C01G12.6 F35C5.11 F35C5.11 Protein of unknown function, has high similarity to uncharacterized C. elegans F28A12.3 F35C5.12 F35C5.12 Protein of unknown function F35C5.2 F35C5.2 Member of C. elegans Sra integral membrane protein family, which contain 6-7 hydrophobic, putative transmembrane, regions, has moderate similarity to uncharacterized C. elegans SRA-10 7TM chemoreceptor, sra family F35C5.3 F35C5.3 Protein of unknown function, has low similarity to a region of S. cerevisiae Muc1p, which is cell surface flocculin and is required for invasive and pseudohyphal growth F35C5.4 F35C5.4 Protein of unknown function F35C5.5 F35C5.5 Protein containing two C-type lectin domains and two von Willebrand factor (vWF) type A domains, has high similarity to uncharacterized C. elegans F35C5.6 Lectin C-type domain short and long forms, von Willebrand factor type A domain F35C5.6 F35C5.6 Member of the C-type lectin protein family Lectin C-type domain short and long forms, von Willebrand factor type A domain F35C5.7 F35C5.7 Member of the C-type lectin protein family Lectin C-type domain short and long forms, von Willebrand factor type A domain F35C5.8 F35C5.8 Protein containing a C-type lectin domain and a von Willebrand factor (vWF) type A domain, has high similarity to uncharacterized C. elegans F35C5.9 von Willebrand factor type A domain F35C5.9 F35C5.9 Member of the C-type lectin protein family Lectin C-type domain short and long forms, von Willebrand factor type A domain F35C8.1 F35C8.1 Protein containing two protein kinase domains, has a region of moderate similarity to mitogen-activated protein kinase kinase 6 (rat Map2k6), which is a threonine-tyrosine kinase that activates MAP kinase p38 following heat shock and interleukin 1 beta F35C8.2 F35C8.2 Protein containing a protein kinase domain, has low similarity to a region of mitogen-activated protein kinase kinase 6 (mouse Map2k6), which phosphorylates and activates the MAP kinase p38 (mouse Mm.4437) in response to osmotic shock F35C8.3 jkk-1;F35C8.3 Neuronally expressed serine/threonine protein kinase with strong similarity to human and D. melanogaster MAP kinase kinases (MEK kinases) F35C8.4 syn-1;F35C8.4 Member of the syntaxin family of vesicular transport receptors, has low similarity to C. elegans SYN-4, which is involved in oogenesis syn-1 encodes a syntaxin (t-SNARE) homologous to mammalian and Drosophila syntaxin 1; by homology, SYN-1 is a predicted plasma membrane protein that mediates fusion events between exocytic vesicles and the plasma membrane; however, as loss of syn-1 activity via RNAi does not result in any obvious abnormalities, the precise role of syn-1 in C. elegans development and/or behavior is not yet known. F35C8.5 F35C8.5 Member of the sterol desaturase family, which are involved in cholesterol and plant cuticular wax biosynthesis, has low similarity to cholesterol 25-hydroxylase (human CH25H), which is involved in oxysterol production and lipid and cholesterol metabolism F35C8.6 F35C8.6 Protein with weak similarity to profilin, has strong similarity to C. elegans Y18D10A.T F35C8.7 F35C8.7 Protein has significant similarity to choline transporter-like proteins from human, Drosophila and rat F35C8.8 F35C8.8 Protein of unknown function F35D11.1 F35D11.1 Protein with moderate similarity to C. elegans C25G6.1 gene product F35D11.10 F35D11.10 Protein of unknown function, has low similarity to uncharacterized C. elegans F35D11.8 F35D11.11 F35D11.11 Putative coiled-coil protein, has similarity to human centromere protein CENPE F35D11.2 F35D11.2 Protein of unknown function The protein product of this gene is predicted to contain a glutamine/asparagine (Q/N)-rich ('prion') domain, by the algorithm of Michelitsch and Weissman (as of the WS77 release of WormBase, i.e., in wormpep77). F35D11.3 F35D11.3 Protein of unknown function F35D11.4 F35D11.4 Member of the adenylate cyclase family, which catalyze the conversion of ATP to 3',5'-cyclic AMP and pyrophosphate F35D11.5 F35D11.5 Protein of unknown function F35D11.6 F35D11.6 Protein of unknown function F35D11.7 F35D11.7 Protein of unknown function, has moderate similarity to uncharacterized C. elegans F35D11.8 F35D11.8 F35D11.8 Protein of unknown function, has high similarity to uncharacterized C. elegans F35D11.9 F35D11.9 F35D11.9 Protein of unknown function, has high similarity to uncharacterized C. elegans F35D11.8 F35D2.1 F35D2.1 Protein with strong similarity to C. elegans F35D2.2 gene product F35D2.2 F35D2.2 Protein with strong similarity to C. elegans C26B9.2 gene product F35D2.3 F35D2.3 Protein of unknown function, has a region of low similarity to a region of tenascin C (hexabrachion, human TNC), which is a multidomain extracellular matrix glycoprotein induced by hypoxia that may have a role in cell adhesion and neurite outgrowth F35D2.4 F35D2.4 Protein of unknown function F35D2.5 F35D2.5 Protein contains a putative RhoGAP domain, has strong similarity at the C-terminus to human ABR (active BCR-related) protein, guanine nucleotide regulatory protein transcriptional activator HAP4 and regulatory domain of BCR and P85A F35D6.1 fem-1;isx-1;F35D6.1 Protein required for spermatogenesis; putative ortholog of H. sapiens Hs.6048 gene product The fem-1 gene encodes an ankyrin repeat-containing protein orthologous to human FEM1A and is required for masculinization of germline and somatic tissues; FEM-1 is widely expressed and functions as a second messenger in the sex determination pathway, connecting the membrane protein TRA-2A to the transcription factor TRA-1A which it negatively regulates; FEM-1 may also play a role in apoptosis, as it is a substrate for the CED-3 protease and can induce apoptosis when overexpressed in mammalian cells. F35E12.1 F35E12.1 Member of the SCP-like extracellular protein family testis-specific protein TPX-1 like F35E12.10 F35E12.10 Member of an uncharacterized protein family, predicted to contain a glycosylphosphatidylinositol (GPI) lipid anchor F35E12.2 F35E12.2 Protein of unknown function, has low similarity to uncharacterized C. elegans F35E12.10 F35E12.3 F35E12.3 Protein containing a DUF38 domain of unknown function, has low similarity to C. elegans T07D3.1, which may function in germ-line stem cell differentiation Ser/Thr protein phosphatases; This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins; this gene's encoded protein also contains an FTH/DUF38 motif, which may also mediate protein-protein interaction. F35E12.4 F35E12.4 Protein of unknown function, has moderate similarity to C. elegans F35E12.7; may be anchored to the membrane of a secretory vesicle or the Golgi apparatus F35E12.5 F35E12.5 Protein of unknown function, has high similarity to uncharacterized C. elegans F35E12.6 F35E12.6 F35E12.6 Protein of unknown function, has high similarity to uncharacterized C. elegans F35E12.5 F35E12.7 F35E12.7 Putative paralog of C. elegans F35E12.6 gene product F35E12.8 F35E12.8 Protein of unknown function, has low similarity to uncharacterized C. elegans F20G2.5 F35E12.9 F35E12.9 Protein of unknown function, has low similarity to uncharacterized C. elegans F35E12.2 F35E2.1 F35E2.1 Protein of unknown function, has strong similarity to uncharacterized C. elegans B0546.5 F35E2.2 F35E2.2 Protein containing an F-box domain, which serve as a link between a target protein and a ubiquitin-conjugating enzyme, has low similarity to uncharacterized C. elegans F35E2.8 This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins. F35E2.3 F35E2.3 Protein of unknown function, has low similarity to uncharacterized C. elegans Y47H9B.2 F35E2.4 F35E2.4 Protein of unknown function, has weak similarity to C. elegans F35E2.9 F35E2.5 F35E2.5 Protein of unknown function, has low similarity to uncharacterized C. elegans Y116A8A.6 F35E2.6 F35E2.6 Putative G protein-coupled receptor, member of a subfamily with distant similarity to members of the SRG subfamily, no homolog found in human or D. melanogaster F35E2.7 F35E2.7 Putative G protein-coupled receptor, member of a subfamily with distant similarity to members of the SRG subfamily, no homolog found in human or D. melanogaster F35E2.8 F35E2.8 Protein containing an F-box domain, which serve as a link between a target protein and a ubiquitin-conjugating enzyme, has low similarity to uncharacterized C. elegans C47F8.1 This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins. F35E2.9 F35E2.9 Protein with moderate similarity to C. elegans Y47H9B.2 gene product F35E8.1 F35E8.1 Member of an uncharacterized protein family F35E8.10 F35E8.10 Member of an uncharacterized protein family F35E8.11 cdr-1;F35E8.11 Cadmium-inducible lysosomal protein; related to glutathione S-transferases glutathione S-transferases; cdr-1 encodes a member of the cadmium-inducible lysosomal family that affects susceptibility to cadmium toxicity; expressed in intestinal cells. F35E8.12 F35E8.12 Protein containing nuclear hormone receptor C4-type zinc finger and ligand-binding domains, has low similarity to estrogen-related receptor beta (mouse Esrrb), which is a putative transcription factor that is required for placental development Zinc finger, C4 type (two domains) F35E8.13 F35E8.13 Member of an uncharacterized protein family F35E8.2 F35E8.2 Member of an uncharacterized protein family F35E8.3 F35E8.3 TcA transposase Tc1 transposase F35E8.4 F35E8.4 Member of an uncharacterized protein family F35E8.6 F35E8.6 Member of an uncharacterized protein family F35E8.7 F35E8.7 Member of an uncharacterized protein family F35E8.8 F35E8.8 Protein containing a glutathione S-transferase N-terminal domain, has low similarity to prostaglandin D2 synthase (hematopoietic) (human PGDS), which is a prostaglandin D synthase and glutathione S-transferase that regulates non-rapid eye movement sleep glutathione S-transferase F35E8.9 F35E8.9 Member of an uncharacterized protein family F35F10.1 F35F10.1 Protein of unknown function, has low similarity to uncharacterized C. elegans T20D4.5 F35F10.10 F35F10.10 Protein of unknown function, has high similarity to uncharacterized C. elegans C17B7.5 F35F10.11 F35F10.11 Protein of unknown function, has a region of low similarity to a region of vitamin D-3 upregulated protein-1 (mouse Txnip), which binds to thioredoxin and functions as an oxidative stress mediator by inhibiting thioredoxin activity F35F10.12 F35F10.12 Protein of unknown function, has a region of low similarity to a region of vitamin D-3 upregulated protein-1 (mouse Txnip), which binds to thioredoxin and functions as an oxidative stress mediator by inhibiting thioredoxin activity F35F10.13 F35F10.13 Protein containing a DUF19 domain of unknown function, which contain twelve conserved cysteines, has moderate similarity to uncharacterized C. elegans T28A11.3 F35F10.14 F35F10.14 Protein containing a DUF19 domain of unknown function, which contain twelve conserved cysteines F35F10.2 F35F10.2 Protein containing a DUF40 domain of unknown function, which contain four conserved cysteines, has high similarity to uncharacterized C. elegans T28A11.7 F35F10.4 F35F10.4 Protein containing a DUF19 domain of unknown function, which contain twelve conserved cysteines, has high similarity to uncharacterized C. elegans C04E12.5 F35F10.5 F35F10.5 Protein of unknown function, has strong similarity to uncharacterized C. elegans C17B7.12 F35F10.6 F35F10.6 Protein of unknown function, has high similarity to uncharacterized C. elegans F35F10.7 F35F10.7 F35F10.7 Protein of unknown function, has high similarity to uncharacterized C. elegans F35F10.6 F35F10.8 F35F10.8 Putative ortholog of C. elegans C04E12.8 gene product 7TM chemoreceptor, srx family F35F10.9 F35F10.9 Protein containing a DUF40 domain of unknown function, which contain four conserved cysteines, has strong similarity to uncharacterized C. elegans T28A11.7 F35F11.1 F35F11.1 Putative paralog of C. elegans F35F11.E F35F11.2 F35F11.2 Protein of unknown function, has strong similarity to C. elegans F35F11.D F35F11.3 F35F11.3 Protein of unknown function, putative paralog of C. elegans F35F11.D F35G12.1 F35G12.1 Protein with moderate similarity to malonyl-CoA decarboxylase (human MLYCD), which converts malonyl-CoA to acetyl-CoA and CO2 and may degrade intraperoxisomal malonyl-CoA thereby regulating malonyl-CoA abundance malonyl-COA decarboxylase; F35G12.1 is orthologous to the human gene MALONYL-COA DECARBOXYLASE (MLYCD; OMIM:606761), which when mutated leads to disease. F35G12.10 F35G12.10 Protein with weak similarity to the B chain of ATP synthase, probable paralog of C. elegans F02E8.1 ATP synthase B chain; asb-1 encodes a homolog of ATP synthase B, closely similar to its paralog ASB-2, that is required for embryonic viability and for the normal proliferation of germline cells; asb-1 is preferentially expressed in germline cells, while RNAi of asb-1 causes embryonic lethality and sterility with a defective progression to meiosis. F35G12.11 F35G12.11 Protein with moderate similarity to Drosophila e(r), enhancer of rudimentary protein, member of enhancer of rudimentary protein family, has strong similarity to C. elegans T21C9.4 F35G12.12 F35G12.12 Protein of unknown function F35G12.2 F35G12.2 Putative NAD+-isocitrate dehydrogenase isocitrate dehydrogenase; This gene encodes a protein predicted by Eisenberg and coworkers, with 52% accuracy, to be mitochondrial. F35G12.3 sel-5;sel-5A;sel-5B;F35G12.3 Serine/threonine protein kinase which likely regulates LIN-12 and GLP-1 signaling; has similarity to S. cerevisiae Ark1p and Prk1p protein kinases which are involved in regulation of the cytoskeleton serine/threonine kinase; sel-5 encodes a serine/threonine kinase most similar to mammalian GAK1 and Saccharomyces cerevisiae Pak1p; SEL-5 is required for LIN-12/Notch-mediated signaling events that instruct cells of equivalent developmental potential to adopt distinct fates; sel-5 encodes two protein kinase isoforms generated from alternatively spliced mRNAs and appears to influence cell fate decisions by acting before or during ligand-dependent release of the LIN-12 intracellular domain. F35G12.4 F35G12.4 Protein containing fourteen WD domains (WD-40 repeat), which may mediate protein-protein interactions, has a region of low similarity to S. cerevisiae Asc1p, which is a 40S ribosomal subunit protein that influences translational efficiency and cell size beta-transducin F35G12.5 F35G12.5 Protein of unknown function F35G12.6 mab-21;F35G12.6 Novel protein required for male-specific development mab-21 encodes a novel protein that is a member of a highly conserved family of proteins with Drosophila and vertebrate orthologs; MAB-21 is cell-autonomously required for specifying the identity of sensory ray 6 in the male tail, and also for backward locomotion, normal body morphology, fecundity, and embryonic morphogenesis; MAB-21 expression begins in embryonic hypodermal cells and continues in larval and adult animals in hypodermis, anterior and ventral cord neurons, some body wall muscles, and ray cells. F35G12.7 F35G12.7 Protein with weak similarity to H. sapiens Hs.107187 F35G12.8 F35G12.8 Protein containing an SMC domain N-terminal domain, which bind ATP in chromosome-associated proteins, contains an SMC domain C-terminal domain, which bind ATP in chromosome-associated proteins, has low similarity to C. elegans DPY-27 chromosome segregation protein; The smc-4 gene encodes a homolog of the SMC4 subunit of mitotic condensin; SMC-4 acts with MIX-1 to enable chromosome segregation. F35G12.9 apc-11;F35G12.9 Predicted component of the anaphase-promoting complex or cyclosome (APC/C), required for separation of homologous chromosomes during meiosis I Zinc finger, C3HC4 type (RING finger); apc-11 encodes a predicted key catalytic subunit of the anaphase promoting complex that is required for embryonic development past the embryonic one- cell stage. F35G2.1 F35G2.1 Member of the thioredoxin family, which are small enzymes involved in redox reactions, has low similarity to quiescin Q6 (FAD-dependent sulfhydryl oxidase, rat Qscn6) protein disulphide isomerase-related protein like F35G2.2 F35G2.2 Protein of unknown function E.coli YCAC like F35G2.3 F35G2.3 Protein with weak similarity to H. sapiens Hs.50421 (Human mRNA for KIAA0203 gene, complete cds) F35G2.4 phy-2;F35G2.4 Prolyl 4-hydroxylase alpha subunit prolyl 4-hydroxylase alpha subunit F35G2.5 F35G2.5 Protein of unknown function F35G8.1 F35G8.1 Member of the rhodopsin family of G protein-coupled receptors (GPCR), has low similarity to C. elegans NPR-1 G-protein coupled receptor F35H10.1 his-30;F35H10.1 Histone H2A in the HIS3 gene cluster histone H2A; his-30 encodes an H2A histone; by homology, HIS-30 is predicted to function as a nucleosome component required for packaging of DNA into chromatin; his-30 is a replication-dependent histone locus that resides in the HIS5 cluster on chromosome IV. F35H10.10 celf35-1;F35H10.10 Member of the metabotrobic glutamate family of G protein-coupled receptors (GPCR), has a region of weak similarity to metabotropic glutamate receptor 4 (human GRM4), which inhibits adenylyl cyclase and may be associated with juvenile myoclonic epilepsy F35H10.11 F35H10.11 Putative ortholog of C. elegans C50F4.5 gene product histone H2B; his-29 encodes an H2B histone. F35H10.2 F35H10.2 Protein of unknown function F35H10.3 F35H10.3 Protein of unknown function F35H10.4 vha-5;F35H10.4 Member of the vacuolar H+-ATPase protein family hydrogen ion transport F35H10.5 F35H10.5 Protein of unknown function F35H10.6 F35H10.6 Protein of unknown function F35H10.7 F35H10.7 Protein of unknown function, has weak similarity to uncharacterized conserved gene telomeric to alpha globin cluster (human CGTHBA) F35H12.1 F35H12.1 Protein of unknown function, has weak similarity across the middle region to human Hs.61490 (isolated from human brain cDNA library) F35H12.2 F35H12.2 Protein containing two phosphotyrosine interaction (PTB/PID) and two TBC domains, has moderate similarity to RAB6 GTPase activating protein, (GAP and centrosome-associated, human GAPCENA), which plays roles in microtubule nucleation and Golgi dynamics F35H12.3 sel-12;sum-1;F35H12.3 Presenilin affecting LIN-12 and GLP-1 signal transduction; plays a role in cell fate decisions; related to the H. sapiens presenilins which are implicated in early onset Alzheimer's disease The sel-12 gene encodes a ortholog of human PS1, which when mutated leads to type 3 Alzheimer disease (OMIM:104311); it is also homologous to PS2, which when mutated leads type 4 Alzheimer disease (OMIM:600759). F35H12.4 F35H12.4;sel-12 Protein containing a phosphatidylinositol 3- and 4-kinase domain, has moderate similarity to phosphatidylinositol 4-kinase beta (human PIK4CB), which is a wortmannin-sensitive lipid kinase that is required for the proper organization of the Golgi complex phosphatidylinositol 4-kinase F35H12.5 F35H12.5 Protein of unknown function, putative paralog of C. elegans C31H5.1 F35H8.1 F35H8.1 Protein of unknown function F35H8.2 F35H8.2 Member of the core-2 or I-branching enzyme family, which form blood group I-antigens or side-chains of O-glycans, has weak similarity to uncharacterized C. elegans T28F3.9 F35H8.3 F35H8.3 Protein containing a putative C2H2-type zinc finger domain, has similarity to human Hs.75471/OZF protein Zinc finger, C2H2 type (7 domains) F35H8.4 F35H8.4 Protein of unknown function F35H8.5 elr-1;exc-7;F35H8.5 Ribonucleoprotein related to Drosophila ELAV, involved in cholinergic neuron development HUD; exc-7 encodes an ELAV, an mRNA-binding protein homologous to Drosophila ELAV and human HuC/D (OMIM:603458, 168360, autoimmune antigens associated with paraneoplastic neurologic disorders); EXC-7 is required for formation of the tailspike and the excretory cell canals; exc-7 mutations enhance defects produced by mutations in exc-3, predicted to encode a peptidase, and sma-1, which encodes beta H-spectrin, a key component of the apical cytokeleton of polarized epithelial cells such as the excretory cell; in vitro, EXC-7 can bind the sma-1 mRNA 3' UTR, and thus is predicted to regulate SMA-1 expression in vivo; EXC-7 is expressed transiently in the excretory cell nucleus during mid-embryogenesis and during larval stages is detected in the pharynx, nerve ring, and nerve cord nuclei. F35H8.6 F35H8.6 Protein containing a UDP-glucoronosyl and UDP-glucosyl transferase domain, has low similarity to UDP-glucuronosyltransferase 8 (UDP-galactose ceramide galactosyltransferase, rat Ugt8), which acts in the biosynthesis of galactosylceramide UDP-glucuronosyltransferase F35H8.7 wee-1.1;F35H8.7 Serine/threonine/tyrosine protein kinase of the WEE1 family with similarity to human, D. melanogaster, and S. cerevisiae tyrosine- and threonine-specific cdc-2 inhibitory kinases serine/threonine kinase F36A2.1 F36A2.1 Protein of unknown function, has weak similarity to C. elegans C02F5.4 F36A2.10 F36A2.10 Protein of unknown function F36A2.11 F36A2.11 Protein of unknown function F36A2.12 F36A2.12 Protein with weak similarity to C. elegans F02E9.3 gene product F36A2.13 F36A2.13 Protein containing a putative zinc finger in N-recognin domain, a UBA (ubiquitin associated) or TS-N domain, and a HECT domain, has a region of low similarity to a region of E6-associated-protein (E6-AP) ubiquitin-protein ligase (mouse Ube3a) F36A2.2 F36A2.2 Putative ortholog of S. cerevisiae Yml080p a protein of unknown function Yeast protein 8248 like; This gene encodes a protein predicted by Eisenberg and coworkers, with 52% accuracy, to be mitochondrial. F36A2.3 F36A2.3 Member of the malate or L-lactate dehydrogenase family, which are involved in sugar metabolism, has high similarity to uncharacterized C. elegans VF13D12L.3 F36A2.4 F36A2.4 Member of the ion transport family, contains two fibronectin type III domains, has a region of low similarity to a region of potassium channel subfamily K member 6 (rat Kcnk6), which is an outward and mild inward rectifying potassium channel potassium channel protein F36A2.6 F36A2.6 Putative ribosomal protein S15 (yeast S21, rp52, E. coli S19, rat S15) 40S ribosomal protein S15; rps-15 encodes a small ribosomal subunit S15 protein. F36A2.7 F36A2.7 Protein of unknown function, has high similarity to uncharacterized C. elegans F22B5.4 F36A2.8 F36A2.8 Protein with weak similarity to D. melanogaster janA (janus A) Drosophila sex-regulated protein janus like F36A2.9 F36A2.9 Member of the phospholipase protein family, putative paralog of C. elegans Y9C12A.B phospholipase F36A4.1 F36A4.1 Protein with strong similarity to C. elegans F36A4.2 gene product F36A4.10 col-34;alpha-collagen;F36A4.10 Collagen cuticular collagen; col-34 encodes a cuticle collagen protein and is a critical component of male tail cuticle organization affecting ray morphology. F36A4.11 F36A4.11 Protein of unknown function F36A4.14 nhr-78;F36A4.14 Member of the zinc finger, C4 type protein family with similarity to nuclear hormone receptors F36A4.2 F36A4.2 Protein of unknown function, has high similarity to uncharacterized C. elegans F36A4.4 F36A4.3 F36A4.3 Protein of unknown function, has high similarity to uncharacterized C. elegans F36A4.4 F36A4.4 F36A4.4 Protein of unknown function, has high similarity to uncharacterized C. elegans F36A4.2 F36A4.5 F36A4.5 Protein of unknown function, has weak similarity to C. elegans F47C12.8 F36A4.6 col-33;F36A4.6 Protein with high similarity to C. elegans SQT-3, which is a collagen involved in morphogenesis of epithelium and cuticle synthesis, contains two collagen triple helix repeats and one nematode cuticle collagen N-terminal domain cuticular collagen; col-33 encodes a predicted cuticular collagen; by homology, col-33 is predicted to play a role in cuticle biosynthesis and regulation of body size and morphogenesis; however, as loss of col-33 activity via large-scale RNAi screens does not result in any obvious abnormalities, the precise role of COL-33 in C. elegans development and/or behavior is not yet known. F36A4.7 ama-1;CeRpb1;F36A4.7 Largest subunit of RNA Polymerase II RNA polymerase II; ama-1 encodes the large subunit of RNA polymerase II required for mRNA transcription; AMA-1 is essential for proper embryonic development, particularly for the early division and migration of the endodermal precursor (E) cells that initiate gastrulation; AMA-1 is expressed ubiquitously in the developing embryo until the 550-cell stage. F36A4.8 F36A4.8 Member of the transthyretin-like family, has high similarity to uncharacterized C. elegans R90.2 F36D1.1 F36D1.1 Protein with moderate similarity to C. elegans Y106G6H.4 gene product F36D1.2 F36D1.2 Member of the C. elegans Sre G protein-coupled chemoreceptor family, which are putative chemosensory receptors, has low similarity to uncharacterized C. elegans ZC455.7 7TM receptor, sre family F36D1.3 F36D1.3 Protein containing a DUF215 domain of unknown function, has low similarity to uncharacterized C. elegans R07B5.6 F36D1.4 F36D1.4 Protein with weak similarity to C. elegans ZK666.2 gene product F36D1.5 F36D1.5 Protein of unknown function F36D1.6 F36D1.6 Protein of unknown function, has low similarity to uncharacterized C. elegans Y47H9B.2 F36D1.7 F36D1.7 Protein of unknown function F36D1.8 F36D1.8 Protein of unknown function, has high similarity to uncharacterized C. elegans F49D11.3 F36D3.1 F36D3.1 Putative ortholog of C. elegans F36D3.12 gene product F36D3.10 F36D3.10 Protein of unknown function, has moderate similarity to uncharacterized C. elegans ZK39.3 F36D3.12 F36D3.12 Putative ortholog of C. elegans F36D3.1 gene product F36D3.2 nhr-54;F36D3.2 Member of the nuclear hormone receptor/Zinc finger protein family Zinc finger, C4 type (two domains) F36D3.3 F36D3.3 Protein of unknown function, has high similarity to uncharacterized C. elegans T26H2.8 F36D3.4 F36D3.4 Protein containing a major sperm protein (MSP) domain, which are involved in sperm motility, has strong similarity to uncharacterized C. elegans F21H7.5 F36D3.5 F36D3.5 Protein containing a BRCA1 (breast cancer type 1) C terminus (BRCT) domain, which are found in some cell cycle checkpoint proteins, an ankyrin (Ank) repeat and a WSN domain of unknown function, has high similarity to uncharacterized C. elegans F26D2.10 Ank repeat F36D3.6 F36D3.6 Member of the 7-transmembrane chemoreceptor family of G protein-coupled receptors (GPCR), has moderate similarity to uncharacterized C. elegans F57E7.3 G-protein coupled receptor, srh family F36D3.7 F36D3.7 Member of the 7-transmembrane chemoreceptor family of G protein-coupled receptors (GPCR), has moderate similarity to uncharacterized C. elegans T16A9.2 F36D3.8 F36D3.8 Protein of unknown function, has moderate similarity to uncharacterized C. elegans F10G2.7 F36D3.9 F36D3.9 Protein with high similarity to cathepsin B (human CTSB), which is a cysteine (thiol) protease that degrades cartilage matrix proteins and facilitates tumor invasion, member of the papain family of cysteine proteases cysteine protease F36D4.1 F36D4.1 Protein of unknown function F36D4.2 F36D4.2 Protein with high similarity to synbindin (mouse Sbdn), which is a syndecan-binding protein that may be involved in membrane trafficking and acts with syndecan to initiate dendritic spine formation in postsynaptic membranes of hippocampal neurons synbindin TRS23 family F36D4.3 hum-2;F36D4.3 Myosin I, class V unconventional myosin heavy chain myosin; hum-2 is orthologous to the human gene MYOSIN HEAVY CHAIN 12 (MYO5A; OMIM:160777), which when mutated leads to disease. F36D4.4 F36D4.4 Member of the rhodopsin family of G protein-coupled receptors (GPCR) F36D4.5 F36D4.5 Protein of unknown function F36D4.6 F36D4.6 Protein with moderate similarity to C. elegans W06H3.1 gene product F36F12.1 F36F12.1 Protein containing a DUF23 domain of unknown function, has moderate similarity to uncharacterized C. elegans F55C10.4 F36F12.2 F36F12.2 Protein containing a DUF23 domain of unknown function, has high similarity to uncharacterized C. elegans F22F7.4 F36F12.3 F36F12.3 Protein containing a DUF138 domain of unknown function F36F12.4 F36F12.4 Protein with moderate similarity to C. elegans F15D4.3 gene product F36F12.5 F36F12.5 Protein containing a C-type lectin domain, which mediate calcium-dependent carbohydrate recognition, has strong similarity to uncharacterized C. elegans F36F12.6 F36F12.6 F36F12.6 Protein containing a C-type lectin domain, which mediate calcium-dependent carbohydrate recognition, has strong similarity to uncharacterized C. elegans F36F12.5 F36F12.7 F36F12.7 Protein of unknown function F36F12.8 F36F12.8 Protein containing three C2H2 type zinc finger domains, has a region of moderate similarity to a region of C. elegans HAM-2, which is a putative transcription factor required for migration of hermaphrodite-specific neurons zinc finger protein F36F2.1 F36F2.1 Protein with strong similarity to C. elegans T04A8.4 gene product F36F2.2 F36F2.2 Protein of unknown function F36F2.3 F36F2.3 Protein with a region of strong similarity to N-terminus of human CTDP1 (RNA polymerase II CTD (carboxy-terminal domain) phosphatase, subunit 1) Zinc finger, C3HC4 type (RING finger), Zinc finger, CCHC class F36F2.4 F36F2.4 Member of the syntaxin family of vesicular transport receptors, has low similarity to C. elegans UNC-64, which is involved in synaptic vesicle transport, protein secretion, locomotion, axon cargo transport and neurotransmitter release Syntaxin F36F2.5 tax-2;F36F2.5 Beta-subunit of a cyclic nucleotide-gated channel required for thermosensation, chemosensation, and normal outgrowth and guidance of some sensory neuron axons cyclic nucleotide-gated channel; tax-2 is orthologous to the human gene ROD PHOTORECEPTOR CNG-CHANNEL BETA SUBUNIT (CNGB1; OMIM:600724), which when mutated leads to disease. F36F2.6 F36F2.6 Protein of unknown function F36G3.1 F36G3.1 Putative coiled-coil protein, has weak similarity at the C-terminus to D. melanogaster HK (hook) protein F36G3.2 F36G3.2 Protein with strong similarity to C. elegans F21C10.9 gene product F36G9.1 F36G9.1 Protein of unknown function, has low similarity to uncharacterized C. elegans T05G11.6 F36G9.10 F36G9.10 Member of the 7-transmembrane chemoreceptor family of G protein-coupled receptors (GPCR), has moderate similarity to uncharacterized C. elegans F36G9.9 F36G9.11 F36G9.11 Protein containing a C-type lectin domain, which mediate calcium-dependent carbohydrate recognition, has moderate similarity to uncharacterized C. elegans F21H7.4 Lectin C-type domain F36G9.12 F36G9.12 Member of the uncharacterized protein family UPF0063, has high similarity to uncharacterized C. elegans C31A11.7 F36G9.13 F36G9.13 Member of an uncharacterized protein family F36G9.14 F36G9.14 Protein containing an F-box domain, which serve as a link between a target protein and a ubiquitin-conjugating enzyme, and a DUF38 domain of unknown function, has low similarity to C. elegans FOG-2, which is required for the sexual identity of germ cells This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins; this gene's encoded protein also contains an FTH/DUF38 motif, which may also mediate protein-protein interaction. F36G9.15 F36G9.15 Protein of unknown function, has strong similarity to uncharacterized C. elegans C06C6.8 F36G9.2 F36G9.2 Member of the 7-transmembrane chemoreceptor family of G protein-coupled receptors (GPCR), has moderate similarity to uncharacterized C. elegans F47D2.10 F36G9.3 F36G9.3 Member of the sugar (and other) transporter family, has high similarity to uncharacterized C. elegans M153.2 F36G9.5 F36G9.5 Protein containing a DUF215 domain of unknown function, has high similarity to uncharacterized C. elegans F36G9.6 7TM receptor F36G9.6 F36G9.6 Protein containing a DUF215 domain of unknown function, has high similarity to uncharacterized C. elegans F36G9.5 7TM receptor F36G9.7 F36G9.7 Protein of unknown function F36G9.8 F36G9.8 Member of the 7-transmembrane chemoreceptor family of G protein-coupled receptors (GPCR), has high similarity to uncharacterized C. elegans F36G9.9 7TM chemoreceptor, sri family F36G9.9 F36G9.9 Member of the 7-transmembrane chemoreceptor family of G protein-coupled receptors (GPCR), has high similarity to uncharacterized C. elegans F36G9.8 7TM chemoreceptor, sri family F36H1.1 F36H1.1 Protein with high similarity to FK506-binding protein 2 (FKBP13, human FKBP2), which binds FK506 and rapamycin but does not play a role in the immunosuppressant action of FK506, member of the FKBP-type peptidyl-prolyl cis-trans isomerase family FK506-binding protein; fkb-1 encodes a homolog of mouse FK506-binding protein 2. F36H1.2 F36H1.2 Protein containing ten ankyrin (Ank) repeats, has a region of low similarity to a region of ankyrin 1 (mouse Ank1), which is a cytoskeletal anchor protein that attaches cytoskeletal elements to the plasma membrane and is associated with normoblastosis ankyrin like F36H1.3 F36H1.3 Member of the protein-tyrosine phosphatase family, which are involved in control of cell growth, proliferation, differentiation and transformation, has a region of low similarity to rat Ptp20, which is a protein tyrosine phosphatase protein-tyrosine phosphatase F36H1.4 lin-3;F36H1.4 Inductive signal of the gonadal anchor cell required for vulva differentiation, putative ligand for LET-23 receptor lin-3 growth factor precursor; The lin-3 gene encodes a member of the EGF family of peptide growth factors, that affects induction of vulval development, viability, ovulation, and male spicule deveopment; it acts genetically upstream of let-23, and is expressed in the anchor cell of the developing gonad. F36H1.5 F36H1.5 Protein of unknown function, has low similarity to uncharacterized C. elegans R02E12.6 F36H1.6 F36H1.6 Protein with high similarity to 10-formyltetrahydrofolate dehydrogenase (rat Fthfd), which acts to oxidize 10-formyltetrahydrofolate, member of the aldehyde dehydrogenase and formyl transferase families, contains a formyl transferase C terminal domain formyltetrahydrofolate dehydrogenase; alh-3 encodes an aldehyde dehydrogenase predicted to be mitochondrial. F36H12.1 F36H12.1 Protein of unknown function F36H12.10 F36H12.10 Member of the protein-tyrosine phosphatase family, which are involved in control of cell growth, proliferation, differentiation and transformation, has moderate similarity to C. elegans F10G8.1, which is involved in embryogenesis or morphogenesis F36H12.11 F36H12.11 Protein of unknown function, has strong similarity to uncharacterized C. elegans R13H9.1 F36H12.13 F36H12.13 Protein of unknown function F36H12.14 F36H12.14 Protein of unknown function, has low similarity to uncharacterized C. elegans C29F5.2 F36H12.15 F36H12.15 Protein of unknown function F36H12.16 F36H12.16 Protein of unknown function F36H12.17 F36H12.17 Protein of unknown function F36H12.2 F36H12.2 Putative ortholog of C. elegans C35E7.8 gene product F36H12.3 F36H12.3 Protein containing a major sperm protein (MSP) domain, which are involved in sperm motility, has high similarity to uncharacterized C. elegans C35E7.9 F36H12.4 F36H12.4 Protein of unknown function F36H12.5 F36H12.5 Protein of unknown function, has high similarity to uncharacterized C. elegans T13A10.1 F36H12.7 msp-19;F36H12.7 Sperm-specific protein involved in sperm motility, member of the major sperm protein (MSP) family major sperm protein MSP-19; msp-19 encodes a protein that belongs to a family of proteins called the Major Sperm Proteins (MSPs) that is conserved in nematodes; msp-19 has a homolog in C. briggsae as predicted by the Wobble Aware Bulk Aligner (WABA); the msp gene family consists of closely related, small, basic proteins that make up 15% of sperm protein; this multigene family consists of over fifty genes, including many pseudogenes; MSPs are involved in both extracellular signaling and cytoskeletal functions during reproduction-MSP antagonizes Eph/ephrin signaling, in part, by binding VAB-1 Eph receptor tyrosine kinase on oocytes and sheath cells to promote oocyte maturation and MAPK activation; MSPs assemble into fibrous networks that drive movement of the C. elegans sperm; msp genes are expressed only in late primary spermatocytes. F36H12.8 F36H12.8 Protein containing a protein kinase domain, has low similarity to C. elegans Y106G6E.6, which is involved in embryogenesis and morphogenesis F36H12.9 F36H12.9 Protein containing a protein kinase domain, has low similarity to C. elegans Y106G6E.6, which is involved in embryogenesis and morphogenesis F36H2.1 F36H2.1 Member of the P-type ATPase, Drs2p subfamily protein family E1-E2 ATPase F36H2.2 F36H2.2 Member of the nucleoside transporter family, has weak similarity to solute carrier family 29 member 1 (equilibrative nucleoside transporter 1) (mouse Slc29a1), which functions in the transport of physiologic nucleosides and nucleoside analog drugs F36H2.3 F36H2.3;NHL Protein containing twenty sushi or short consensus repeat (SCR) domains, which are found in complement and adhesion proteins, has a region of weak similarity to complement factor H (human HF1), which controls complement activation and pathogen recognition Complement factor H precursor like F36H5.1 F36H5.1 Protein containing six meprin and TRAF homology (MATH) domains, has strong similarity to uncharacterized C. elegans F36H5.2 The F36H5.1 gene encodes a protein closely similar to F36H5.2, which has a meprin-associated Traf homology (MATH) domain and may be involved in apoptosis. F36H5.10 F36H5.10 Protein with strong similarity to C. elegans F36H5.4 gene product F36H5.11 F36H5.11 Protein with strong similarity to C. elegans C08F1.3 gene product F36H5.2 F36H5.2 Protein containing six meprin and TRAF homology (MATH) domains, has strong similarity to uncharacterized C. elegans F36H5.1 The F36H5.2 gene encodes a protein with a meprin-associated Traf homology (MATH) domain that may be involved in apoptosis. F36H5.3 F36H5.3 Protein containing six meprin and TRAF homology (MATH) domains, has moderate similarity to uncharacterized C. elegans F36H5.1 F36H5.4 F36H5.4 Protein of unknown function, has high similarity to uncharacterized C. elegans C08F1.6 F36H5.5 F36H5.5 Protein containing an F-box domain, which serve as a link between a target protein and a ubiquitin-conjugating enzyme, has low similarity to uncharacterized C. elegans F45C12.5 This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins; its encoded protein also contains a Pfam-B45 motif of presently unknown function. F36H5.6 F36H5.6 Protein containing a C-type lectin domain, which mediate calcium-dependent carbohydrate recognition, has moderate similarity to uncharacterized C. elegans C54C8.7 F36H5.8 F36H5.8 Protein containing an F-box domain, which serve as a link between a target protein and a ubiquitin-conjugating enzyme, has low similarity to uncharacterized C. elegans F36H5.11 This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins. F36H5.9 F36H5.9 Protein containing an F-box domain, which serve as a link between a target protein and a ubiquitin-conjugating enzyme This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins; its encoded protein also contains a Pfam-B45 motif of presently unknown function. F36H9.1 F36H9.1 Protein of unknown function, putative paralog of C. elegans F36H9.2 F36H9.2 F36H9.2 Protein of unknown function, putative paralog of C. elegans F36H9.1 F36H9.3 F36H9.3 Protein with strong similarity to D. melanogaster CG10672 (CG10672 gene product) alcohol dehydrogenase; dhs-13 encodes a short-chain dehydrogenase predicted to be mitochondrial. F36H9.4 F36H9.4 Protein of unknown function, has weak similarity to C. elegans B0238.12 F36H9.5 F36H9.5 Protein of unknown function, has strong similarity to C. elegans C14B9.3 F36H9.6 F36H9.6 Protein of unknown function, putative paralog of C. elegans Y46H3A.1 7TM chemoreceptor, srt family F37A4.1 F37A4.1 Member of the alpha or beta hydrolase fold family, has low similarity to uncharacterized mouse AI326074 F37A4.2 F37A4.2 Protein of unknown function F37A4.3 F37A4.3 Protein of unknown function, has weak similarity to C. elegans F30F8.2 F37A4.4 F37A4.4 Protein containing four BRCA1 (breast cancer type 1) C terminus (BRCT) domains, two ankyrin (Ank) repeats, and two WSN domains of unknown function, has low similarity to uncharacterized C. elegans C01G10.1 F37A4.5 F37A4.5 Protein with high similarity to 26S proteasome-associated Pad1 homolog (human POH1), which is a subunit of the 26S proteasome that confers multidrug resistance and resistance to ultraviolet light, member of the Mov34, MPN or PAD-1 family F37A4.6 F37A4.6 Protein of unknown function F37A4.7 rbf-1;F37A4.7 Protein containing ten C2 domains, which may be involved in calcium-dependent phospholipid binding, and five Rabphilin-3A effector domains, which are involved in protein transport in synaptic vesicles, has low similarity to rabphilin-3A (mouse Rph3a) F37A4.8 F37A4.8 Protein with high similarity to human SMARCA1, which is part of a complex involved in histone assembly, contains two Myb-like DNA-binding domains, two AT-hook motifs, two SNF2 related N-terminal domains, and two helicase conserved C-terminal domains isw-1 encodes a homolog of the chromatin remodeling ATPase ISW1 that may act downstream of or in parallel to synMuv genes, and upstream of or in parallel to the RTK Ras pathway. F37A4.9 F37A4.9 Protein containing a BTB (BR-C, ttk and babor) or POZ (Pox virus and zinc finger) domain and a meprin and TRAF homology (MATH) domain, has weak similarity to uncharacterized speckle-type POZ protein (mouse Spop) The F37A4.9 gene encodes a protein with a meprin-associated Traf homology (MATH) domain that may be involved in apoptosis. F37A8.1 F37A8.1 Protein of unknown function, has strong similarity to uncharacterized C. elegans F26F4.2 F37A8.2 F37A8.2 Protein of unknown function, has strong similarity to uncharacterized C. elegans Y45F10B.2 F37A8.4 F37A8.4 GGxYamide neurotransmitter nlp-10 encodes four predicted neuropeptide-like proteins; nlp-10 is part of a GGxY neuropeptide family that has members in several other nematode species; nlp-10 is expressed in a variety of neurons, including ASK, ADL, CAN, two lateral neurons, two anterior pharyngeal neurons, one tail neuron, and one male tail neuron; as loss of nlp-10 activity via large-scale RNAi screens does not result in any obvious abnormalities, the precise role of nlp-10-encoded peptides in development and/or behavior is not yet known. F37A8.5 F37A8.5 Protein with strong similarity to H. sapiens AF060862 (Homo sapiens unknown mRNA) F37B1.1 F37B1.1 Protein containing a glutathione S-transferase N-terminal domain and a glutathione S-transferase C-terminal domain, has moderate similarity to rat Ptgds2, which is a prostaglandin D2 synthase that also functions as a glutathione S-transferase glutathione S-transferase F37B1.2 F37B1.2 Protein containing a glutathione S-transferase N-terminal domain and a glutathione S-transferase C-terminal domain, has low similarity to mouse Ptgds2, which is an enzyme that functions as both a prostaglandin D synthase and a glutathione S-transferase glutathione S-transferase F37B1.3 F37B1.3 Protein containing glutathione S-transferase N-terminal and C-terminal domains, has low similarity to prostaglandin D2 synthase 2 (mouse Ptgds2), which functions as both a prostaglandin D synthase and a glutathione S-transferase glutathione S-transferase F37B1.4 F37B1.4 Member of the glutathione S-transferase protein family, has similarity to human and D. melanogaster glutathione S-transferases glutathione S-transferase F37B1.5 F37B1.5 Member of the glutathione S-transferase protein family, has similarity to human and D. melanogaster glutathione S-transferases glutathione S-transferase F37B1.6 F37B1.6 Protein containing a glutathione S-transferase C-terminal domain, which may be involved in conjugation of reduced glutathione to various targets glutathione S-transferase F37B1.7 F37B1.7 Protein containing glutathione S-transferase N-terminal and C-terminal domains, has low similarity to prostaglandin D2 synthase (human PGDS), which is a prostaglandin D synthase and glutathione S-transferase that regulates non-rapid eye movement sleep glutathione S-transferase F37B1.8 F37B1.8 Protein containing glutathione S-transferase N-terminal and C-terminal domains, has low similarity to prostaglandin D2 synthase (human PGDS), which is a prostaglandin D synthase and glutathione S-transferase that regulates non-rapid eye movement sleep glutathione S-transferase F37B12.1 F37B12.1 Protein of unknown function F37B12.2 F37B12.2 Protein with high similarity to glutamate-cysteine ligase catalytic subunit (gamma-glutamylcysteine synthetase, human GCLC), which catalyzes the first step of glutathione synthesis, member of the glutamate-cysteine ligase catalytic subunit family glutamate-cysteine ligase; gcs-1 is orthologous to the human gene SIMILAR TO GLUTAMATE-CYSTEINE LIGASE, CATALYTIC SUBUNIT (GCLC; OMIM:606857), which when mutated leads to disease. F37B12.3 F37B12.3 Protein with weak similarity to C. elegans Y32B12B.1 gene product F37B12.4 F37B12.4 Member of the ubiquitin carboxyl-terminal hydrolase family 2, contains one ubiquitin carboxyl-terminal hydrolases family 2 domain, has a region of low similarity to a region of ubiquitin specific protease 9 Y chromosome (human USP9Y) ubiquitin carboxyl-terminal hydrolase F37B4.1 F37B4.1 Member of the 7-transmembrane chemoreceptor family of G protein-coupled receptors (GPCR), has low similarity to uncharacterized C. elegans D1065.5 7TM chemoreceptor, srh family F37B4.10 F37B4.10 Protein containing a C2H2 type zinc finger domain, which bind nucleic acids F37B4.11 F37B4.11 Protein of unknown function, similar to C. elegans olfactory receptor ODR-10 7TM chemoreceptor, srj family F37B4.12 F37B4.12 Member of the 7-transmembrane chemoreceptor family of G protein-coupled receptors (GPCR), has low similarity to C. elegans ODR-10, which is a G protein-coupled receptor involved in odorant response 7TM chemoreceptor, str family F37B4.13 F37B4.13 Protein of unknown function, has strong similarity to C. elegans F37B4.6 7TM chemoreceptor, srh family F37B4.2 ifc-1;Cel-IF-C1;F37B4.2 Putative intermediate filament protein intermediate filament protein; ifc-1 encodes a nonessential intermediate filament protein; IFC-1 is predicted to function as a structural component of the cytoskeleton; IFC-1 has no function in RNAi assays. F37B4.3 F37B4.3 Member of the 7-transmembrane chemoreceptor family of G protein-coupled receptors (GPCR), has high similarity to uncharacterized C. elegans C03G6.9 7TM chemoreceptor, srh family F37B4.4 F37B4.4 Member of the 7-transmembrane chemoreceptor family of G protein-coupled receptors (GPCR), has high similarity to uncharacterized C. elegans W02H5.6 7TM chemoreceptor, srh family F37B4.6 F37B4.6 Member of the 7-transmembrane chemoreceptor family of G protein-coupled receptors (GPCR), has high similarity to uncharacterized C. elegans F37B4.3 7TM chemoreceptor, srh family F37B4.7 F37B4.7 Putative folate transporter, has strong similarity to human reduced folate carrier protein (RFC-like, Hs.173314) folate transporter; The F37B4.7 gene encodes a folate transporter homologous to human SLC19A2. F37B4.8 F37B4.8 Protein containing a CX module domain 7TM chemoreceptor, srw family F37B4.9 F37B4.9 Member of the C. elegans Sre G protein-coupled chemoreceptor family, which are putative chemosensory receptors, has high similarity to uncharacterized C. elegans Y57A10C.4, which is a putative G protein-coupled receptor 7TM chemoreceptor, sre family F37C12.1 F37C12.1 Protein of unknown function, has moderate similarity to uncharacterized human FLJ10374 F37C12.10 F37C12.10 Protein of unknown function F37C12.11 F37C12.11 Member of the ribosomal protein S21 protein family Ribosomal protein S21; rps-21 encodes a small ribosomal subunit S21 protein; by homology, RPS-21 is predicted to function in protein biosynthesis; in C. elegans, RPS-21 activity is required for embryonic and germline development, as well as the overall health of the animal. F37C12.12 F37C12.12 Member of the aldo-keto reductase family, which include some related monomeric NADPH-dependent oxidoreductases mec-14 encodes a protein with similarity to the beta-subunits of Shaker-type potassium channels, which are members of the aldo-keto reductase superfamily; MEC-14 is required for response to gentle touch by the six touch receptor neurons, and likely functions to regulate activity of the MEC-4 and MEC-10 degenerin channels; mec-14 expression is detected solely in the touch receptor neurons and is dependent on the MEC-3 LIM domain transcription factor; proper MEC-14 localization in the touch receptor neurons is dependent on MEC-12/alpha-tubulin. F37C12.13 F37C12.13 Member of the RNase PH family of 3' exoribonucleases, which are involved in RNA processing, has a region of low similarity to S. cerevisiae Rrp45p, which is a protein component of the exosome 3'-5' exoribonuclease complex F37C12.14 F37C12.14 Protein of unknown function F37C12.15 srb-8;F37C12.15 G protein-coupled receptor; member of a subfamily with SRB proteins, which are expressed in chemosensory neurons; no homolog found in human or D. melanogaster 7TM chemoreceptor, srb family F37C12.16 srb-9;F37C12.16 Member of an uncharacterized protein family 7TM chemoreceptor, srb family F37C12.17 srb-7;F37C12.17 G protein-coupled receptor; member of a subfamily with SRB proteins, which are expressed in chemosensory neurons; no homolog found in human or D. melanogaster 7TM chemoreceptor, srb family F37C12.2 F37C12.2 Protein with low similarity to p53-induced gene 8 (etoposide-induced 2.4, mouse Ei24), which plays a role in p53-mediated DNA damage response that may include apoptosis and cell proliferation arrest and may also play a role in osteoblast differentiation F37C12.3 F37C12.3 Protein containing a phosphopantetheine attachment site domain, has moderate similarity to uncharacterized C. elegans Y56A3A.O This gene encodes a protein predicted by Eisenberg and coworkers, with 52% accuracy, to be mitochondrial. F37C12.4 F37C12.4 Member of the ribosomal protein L36 protein family Ribosomal protein YL39; rpl-36 encodes a large ribosomal subunit L36 protein; by homology, RPL-36 is predicted to function in protein biosynthesis; in C. elegans, RPL-36 activity is required for embryonic and germline development and normal postembryonic growth rates. F37C12.7 F37C12.7 Protein with high similarity to long-chain fatty acid-Coenzyme A ligase 4 (human FACL4), which functions in lipid metabolism, anti-apoptosis, and possibly in learning and is associated with Alport syndrome, member of the AMP-binding enzyme family F37C12.9 F37C12.9 Member of the ribosomal protein S14 protein family Ribosomal protein S14; rps-14 encodes a small ribosomal subunit S14 protein; by homology, RPS-14 is predicted to function in protein biosynthesis; in C. elegans, RPS-14 activity is required for embryonic and germline development, as well as the overall health of the animal. F37C4.1 F37C4.1 Protein containing two DUF33 domains of unknown function, has high similarity to uncharacterized C. elegans F37C4.2 F37C4.2 F37C4.2 Protein containing a DUF33 domain of unknown function, has high similarity to uncharacterized C. elegans F37C4.3 F37C4.3 F37C4.3 Protein containing a DUF33 domain of unknown function, has high similarity to uncharacterized C. elegans F37C4.2 F37C4.4 F37C4.4 Protein of unknown function F37C4.5 F37C4.5 Protein of unknown function, has moderate similarity to uncharacterized C. elegans ZK1055.7 F37C4.6 F37C4.6 Protein of unknown function phytoene desaturase F37C4.7 F37C4.7 Protein of unknown function F37C4.8 F37C4.8 Protein of unknown function F37D6.1 F37D6.1 Protein with four BRCA1 C-terminus (BRCT) domains, has a region of moderate similarity to H. sapiens Hs.91417 gene product, a DNA topoisomerase II binding protein BRCA1 C Terminus (BRCT) domain (4 domains) F37D6.2 F37D6.2 Protein containing eight C2H2 type zinc finger domains, which bind nucleic acids Zinc finger, C2H2 type (2 domains) F37D6.3 F37D6.3 Protein with weak similarity to C. elegans Y106G6H.2 (Member of the RRM domain protein family) F37D6.4 F37D6.4 Protein containing an F-box domain, which serve as a link between a target protein and a ubiquitin-conjugating enzyme This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins. F37D6.6 F37D6.6 Putative ortholog of C. elegans F37D6.7 gene product F37E3.1 F37E3.1 Putative nuclear cap binding protein, possible ortholog of H. sapiens NCBP CAP-binding protein F37E3.2 F37E3.2 Protein containing seven leucine rich repeats, which mediate protein-protein interactions, has a region of low similarity to a region of adenylate cyclase (ATP pyrophosphate lyase, C. albicans Cyr1p), which generates cAMP in response to activation F37E3.3 F37E3.3 Protein of unknown function F37F2.2 F37F2.2 Member of the SRP19 (signal recognition particle 19) protein family, has a region of high similarity to signal recognition particle 19 kDa (human SRP19), which binds to 7SL RNA and mediates SRP54 binding to the SRP RNA F37F2.3 F37F2.3 Protein containing glutathione S-transferase N-terminal and C-terminal domains, has moderate similarity to glutathione S-transferase pi 2 (mouse Gstp2), which catalyzes the conjugation of glutathione to electrophilic compounds glutathione S-transferase F37H8.1 F37H8.1 Putative transcription factor related to LIN-26 Zinc finger, C2H2 type; lir-3 encodes a lin-26-related protein that shares a unique C2H2 motif together with lir-1, lir-2 and lin-26; contains a region rich in acidic residues suggesting that it may be a transcription factor. F37H8.2 F37H8.2 Protein with moderate similarity to C. elegans zip-1 gene product F37H8.3 F37H8.3 Member of the haloacid dehalogenase or epoxide hydrolase family, has low similarity to a region of epoxide hydrolase cytoplasmic (rat Ephx2), which metabolizes xenobiotic molecules and may play a role in blood pressure regulation haloacid dehalogenase-like hydrolase F37H8.4 F37H8.4 Member of a protein family, has similarity to rat and S. cerevisiae tricarboxylate carriers, has similarity to the SRE subfamily of G protein-coupled receptors F37H8.5 F37H8.5 Protein with strong similarity to C. elegans K07D4.8 gene product F38A1.1 F38A1.1 Member of the C-type lectin family mannose receptor like F38A1.10 F38A1.10 Member of the phospholipase A2 receptor protein family and the C-type lectin family, putative paralog of C. elegans F38A1.5 receptor like F38A1.11 F38A1.11 Protein of unknown function, has weak similarity to C. elegans Y73F8A.Y F38A1.13 F38A1.13 Protein of unknown function, has high similarity to uncharacterized C. elegans C09E9.2 receptor like F38A1.2 F38A1.2 Member of the Tc3 Transposase protein family transposase F38A1.4 F38A1.4 Member of the C-type lectin family, member of the phospholipase A2 receptor protein family, putative paralog of C. elegans F38A1.5 mannose receptor like F38A1.5 F38A1.5 Member of the C-type lectin family, member of the phospholipase A2 receptor protein family phospholipase A2 receptor F38A1.6 F38A1.6 Protein of unknown function, has moderate similarity to uncharacterized C. elegans C09E9.2 F38A1.7 F38A1.7 Protein containing a C-type lectin domain, which mediate calcium-dependent carbohydrate recognition, has high similarity to uncharacterized C. elegans F38A1.5 receptor like F38A1.8 F38A1.8 Protein containing one SRP54-type protein GTPase domain and one signal recognition particle 54 (SRP54)-type protein helical bundle domain, has moderate similarity to signal recognition particle receptor (human SRPR) Signal recognition particle receptor alpha subunit F38A1.9 F38A1.9 Protein with strong similarity to C. elegans F38A1.5 gene product receptor like F38A3.1 F38A3.1 Protein containing two collagen triple helix repeats and one nematode cuticle collagen N-terminal domain, has a region of high similarity to a region of C. elegans CLB-2, which is a type IV collagen of basement membrane collagen F38A3.2 F38A3.2 Protein containing two collagen triple helix repeats and one nematode cuticle collagen N-terminal domain, has moderate similarity to a region of the alpha 1 subunit of type II collagen (human COL2A1), which functions in cartilage development collagen; ram-2 encodes a cuticle collagen that interacts with unc-6 to affect ray cell migration, and interacts with unc-5 and unc-6 to affect embryonic viability; also affects ray morphology in males such that the structural cells and the hypodermis of the rays are swollen in mutants. F38A5.1 F38A5.1 Protein of unknown function F38A5.10 F38A5.10 Protein of unknown function, has very strong similarity to uncharacterized C. elegans F38A5.12 F38A5.11 F38A5.11 Protein containing a DUF41 domain of unknown function F38A5.12 F38A5.12 Protein of unknown function, has very strong similarity to uncharacterized C. elegans F38A5.10 F38A5.13 F38A5.13 Protein containing two Myb-like DNA-binding domains and a DnaJ domain, which are part of chaperone (protein folding) system that mediates interaction with heat shock proteins, has moderate similarity to zuotin related factor 1 (mouse Zrf2) DNA-binding protein; This gene encodes a protein containing a DnaJ ('J') domain. F38A5.2 F38A5.2 Member of the TraB family F38A5.3 lec-11;F38A5.3 Member of the galectin family, which are lectins that bind beta galactosides, has low similarity to uncharacterized C. elegans W01A11.4 lec-11 encodes a predicted member of the galectin family that shares highest similarity with lec-7 through lec-10 within the C-terminal tail and also shares a higher relative histidine content in common with lec-7 through lec-10; can bind sugar in vitro. F38A5.5 F38A5.5 Protein of unknown function, has very strong similarity to uncharacterized C. elegans F38A5.12 F38A5.6 F38A5.6 Protein of unknown function, has high similarity to uncharacterized C. elegans W06D4.3 F38A5.7 F38A5.7 Protein of unknown function, has high similarity to uncharacterized C. elegans F15B10.3 F38A5.8 F38A5.8 Protein of unknown function, has high similarity to uncharacterized C. elegans C09F9.1 F38A5.9 F38A5.9 Protein of unknown function, has very strong similarity to uncharacterized C. elegans F38A5.12 F38A6.1 F38A6.1 Putative transcription factor of the Forkhead/HNF3A family, has strong similarity to C. elegans PHA-4 Fork head domain, eukaryotic transcription factors F38A6.2 F38A6.2 Protein containing seven WD domains (WD-40 repeat), which may mediate protein-protein interactions, has low similarity to uncharacterized echinoderm microtubule-associated protein 2 (human EML2), which may be involved in vision and hearing WD domain, G-beta repeat; elp-1 encodes a WD repeat-containing protein that is the sole C. elegans EMAP (echinoderm microtubule-associated protein) homolog; ELP-1 binds microtubules in vitro, but as loss of ELP-1 function via RNA-mediated interference (RNAi) does not result in any abnormalities, the precise role of ELP-1 in C. elegans development and/or behavior is not yet known; ELP-1 is expressed in many tissues, including body wall muscle, male-specific sex muscles, the vulva, spermatheca, sensory neurons, and intestinal cells. F38A6.3 hif-1;F38A6.3 Hypoxia inducible factor involved in oxygen sensing and response to hypoxia, with 100% identity to human HIF-alpha hif-1 encodes an ortholog of the mammalian hypoxia-induced factor HIF-1, and is required for survival in hypoxic environments (1% oxygen) that have no effect on wild-type C. elegans. F38B2.1 ifa-1;Cel-IF-A1;F38B2.1 Putative intermediate filament protein intermediate filament protein; IFA-1 encodes an essential intermediate filament protein that is coexpressed with the essential IF protein IFB-1; IFA-1 is required for survival past the L1 larva stage, and a normal intestine; IFA-1 forms heteropolymeric intermediate filaments in vitro with an equimolar mixture of IFB-1; IFA-1 is predicted to function as a structural component of the cytoskeleton, and is required for larval development and normal intestinal morphology; ifa-1 is expressed in amphid sensory neurons, in tail neurons and other unidentified neurons, some pharyngeal muscles, the pharyngeal-intestinal valve, the vulva, and the rectum. F38B2.2 F38B2.2 Protein of unknown function, has low similarity to uncharacterized C. elegans K02D3.1 F38B2.3 F38B2.3 Protein containing a CUB domain, which is extracellular in many developmentally regulated proteins, has a region of low similarity to a region of neuropilin 1 (rat Nrp1), which binds to axonal chemorepellent Semaphorin III and functions in axon guidance C1R/C1S-like domain F38B2.4 F38B2.4;XL906 Protein with high similarity to cytosolic adenylate kinase 1 (human AK1), which catalyzes phosphate transfer between adenine nucleotides and is associated with nonspherocytic hemolytic anemia upon deficiency, member of the adenylate kinase family adenylate kinase; F38B2.4 is orthologous to the human gene ADENYLATE KINASE 1 (AK1; OMIM:103000), which when mutated leads to hemolytic anemia. F38B6.1 F38B6.1 Protein of unknown function F38B6.2 F38B6.2 Protein with strong similarity to C. elegans F38B6.7 gene product F38B6.3 F38B6.3 Protein of unknown function F38B6.4 F38B6.4 Member of the formyl transferase family, contains AIR synthase-related protein C-terminal, AIR synthase N-terminal, and phosphoribosylglycinamide synthetase B, C, N, and ATP-grasp (A) domains, has moderate similarity to human GART GARS/AIRS/GART F38B6.5 F38B6.5 Protein with high similarity to C. elegans ROL-8, which is a collagen that is involved in muscle development and cuticle synthesis, contains two collagen triple helix repeats and one nematode cuticle collagen N-terminal domain cuticular collagen F38B6.6 F38B6.6 Protein containing six TPR (tetratrico peptide repeat) domains, has a region of weak similarity to a region of O-linked N-acetylglucosamine transferase (UDP-N-acetylglucosamine:polypeptide-N-acetylglucosaminyltransferase, rat Ogt) F38B6.7 F38B6.7 Protein with strong similarity to C. elegans F38B6.2 gene product F38B7.1 F38B7.1 Protein containing four CCCH-type zinc finger domains, which bind DNA or RNA, has a region of low similarity to a region of zinc finger protein 36 (human ZFP36), which is an immediate early protein that promotes turnover of mRNAs with AU rich elements TIS11B protein like F38B7.2 F38B7.2 Protein of unknown function, has weak similarity to C. elegans F21C10.6 F38B7.3 F38B7.3 Protein containing a pleckstrin homology (PH) domain, which mediate protein-protein and protein-lipid interactions PH (pleckstrin homology) domain F38B7.4 F38B7.4 Protein of unknown function, has moderate similarity to uncharacterized C. elegans H12C20.4 7TM receptor, srx family F38B7.5 F38B7.5 Member of the ovarian tumor (OTU)-like cysteine protease family and the ubiquitin carboxyl-terminal hydrolase family 2, which are cysteine proteases involved in deubiquination, has high similarity to uncharacterized C. elegans F29C4.5 Ubiquitin carboxyl-terminal hydrolase F38B7.6 F38B7.6 Protein with strong similarity to C. elegans H12C20.5 gene product F38B7.7 pms-2;H12C20.2;F38B7.7 Member of the mutL, hexB, or PMS1 family, which are DNA mismatch repair proteins, contains a histidine kinase-like ATPase domain, has low similarity to postmeiotic segregation increased 2 (human PMS2), which is a DNA mismatch repair protein 7TM receptor, srx family F38C2.1 F38C2.1 Protein of unknown function, has strong similarity to uncharacterized C. elegans H25K10.4 F38C2.2 F38C2.2 Protein containing two helix-loop-helix DNA-binding domains, which mediate protein dimerization, has a region of high similarity to a region of human OLIG2, which is involved in transcription repression Helix-loop-helix DNA-binding domain (2 domains) F38C2.4 F38C2.4 Protein of unknown function, has high similarity to uncharacterized C. elegans K06H6.2 F38C2.5 F38C2.5 Protein containing two CCCH-type zinc finger domains, which bind DNA or RNA, has a region of high similarity to a region of C. elegans POS-1, which is a cytoplasmic zinc-finger protein involved in regulation of early morphogenesis Zinc finger C-x8-C-x5-C-x3-H type (and similar). (2 domains) F38C2.6 F38C2.6 Protein containing a C-type lectin domain, which mediate calcium-dependent carbohydrate recognition, has low similarity to uncharacterized C. elegans F11D11.7 Lectin C-type domain F38C2.7 F38C2.7 Protein containing two CCCH-type zinc finger domains, which bind DNA or RNA, has a region of high similarity to a region of C. elegans POS-1, which is involved in regulation of early morphogenesis Zinc finger C-x8-C-x5-C-x3-H type (and similar). (2 domains) F38E1.10 F38E1.10 Protein of unknown function F38E1.11 F38E1.11 Protein of unknown function F38E1.2 F38E1.2 Member of the reverse transcriptase family, which are RNA-dependent DNA polymerases transposon reverse transcriptase F38E1.3 F38E1.3 Protein containing a protein kinase domain, has low similarity to casein kinase 1 alpha 1 (human CSNK1A1), which is a serine/threonine protein kinase that may play a role in Alzheimer's disease serine /threonine-protein kinase F38E1.5 gpa-2;F38E1.5 Trimeric G protein alpha-subunit involved in chemosensation guanine nucleotide-binding protein; gpa-2 encodes a member of the G protein alpha subunit family of heterotrimeric GTPases that is involved in dauer formation and chemotaxis to water-soluble odorants; it is expressed in the phasmid neurons PHA and PHB, three pharyngeal neurons, one interneuron, three pairs of head neurons, and the anal sphincter muscle. F38E1.6 F38E1.6 Protein of unknown function, has weak similarity to uncharacterized C. elegans F18E3.5 F38E1.7 mom-2;F38E1.7 Wnt-related protein required for EMS cell polarization WNT family protein; mom-2 encodes a member of the Wnt family of secreted signaling glycoproteins that is required for induction of endodermal (gut) tissue in the 4-cell stage embryo; MOM-2, required in the inducing blastomere (P2) at the 4-cell stage, may be the ligand for MOM-5, a Frizzled homolog, thought to act in the receiving blastomere (EMS); MOM-2 genetically interacts in the same pathway as KIN-19, but parallel to APR-1; MOM-2 also may be a ligand for LIN-18, a Ryk homolog. | mom-2 encodes a member of the Wnt family of secreted signaling glycoproteins that is required for induction of endodermal (gut) tissue in the 4-cell stage embryo; MOM-2, required in the inducing blastomere (P2) at the 4-cell stage, may be the ligand for MOM-5, a Frizzled homolog, thought to act in the receiving blastomere (EMS); MOM-2 genetically interacts in the same pathway as KIN-19, but parallel to APR-1. F38E1.8 F38E1.8 Protein of unknown function, has moderate similarity to uncharacterized C. elegans C03G6.16 7TM chemoreceptor, srsx family F38E1.9 F38E1.9 Protein with strong similarity to human SL15 protein, identified in a screen of ESTs from CD34+ cells F38E11.2 hsp-12.6;hsp12.6;F38E11.2 Member of the Hsp20 or alpha crystallin family, has a region of moderate similarity to a region of alpha-B crystallin (mouse Cryab), which functions as a molecular chaperone and modulates components of cell remodeling and apoptosis alpha-B-crystallin F38E11.3 cpi-1;F38E11.3 Involved in MAGUK (membrane-associated guanylate kinase) protein targeting at neuronal synapses; weakly similar to S. cerevisiae Ydl238p cpi-1 is orthologous to a mammalian protein variously identified as guanine aminohydrolase (or guanine deaminase, or guanase), cypin, or p51-nedasin. F38E11.4 F38E11.4 Protein containing four PAN domains, which may mediate protein-protein or protein-carbohydrate interactions, has low similarity to uncharacterized C. elegans C34G6.6 F38E11.5 F38E11.5 Protein with high similarity to coatomer protein (COP) complex subunit beta 2 (COP beta prime, mouse Copb2), which is part of a Golgi coatomer complex that may play a role in vesicle transport, contains six WD domains (WD-40 repeat) beta'-coat protein like; F38E11.5 encodes a beta' (beta-prime) subunit of the coatomer (COPI) complex; in mass RNAi assays, F38E11.5 is required for fertility and general health. F38E11.6 F38E11.6 Protein of unknown function F38E11.7 wrt-3;nCNG2;F38E11.7 Putative cyclic nucleotide-gated cation channel wrt-3 encodes a predicted secreted protein that, in C. elegans, comprises one of ten members of the warthog gene family; by homology, WRT-3 is predicted to be involved in cell communication, but as loss of wrt-3 activity via RNA-mediated interference (RNAi) does not result in any obvious abnormalities, the precise role of WRT-3 in C. elegans development and/or behavior is not yet known; a wrt-3 reporter gene is expressed consistently in the trinucleate pharyngeal gland cell g1 beginning at the three-fold stage of embryogenesis, variably in seam cells and hypodermis, and occasionally in single muscle cells and the distal tip cells of late stage larvae and adults. F38E11.9 F38E11.9 Protein with moderate similarity to C. elegans C09E7.E gene product F38E9.1 F38E9.1 Protein of unknown function F38E9.2 F38E9.2 Putative TGF-beta-associated signaling protein, has strong similarity to human and D. melanogaster tolloids and to human bone morphogenetic protein BMP1 F38E9.3 F38E9.3 Member of the reverse transcriptase family, which are RNA-dependent DNA polymerases, has weak similarity to a region of LINE retrotransposable element 1 (human LRE1), which is a reverse transcriptase and endonuclease that mediates L1 element transposition reverse-transcriptase F38E9.4 F38E9.4 Protein of unknown function, has high similarity to uncharacterized C. elegans Y73B6BL.16 F38E9.5 F38E9.5 Protein with low similarity to protein tyrosine kinase 9 (A6 tyrosine kinase, mouse Ptk9), which is a cortical actin cytoskeleton regulator that forms a complex with actin monomers and prevents actin filament assembly protein tyrosine kinase F38E9.6 F38E9.6 Protein of unknown function F38G1.1 che-2;F38G1.1 Required for sensory neuron cilia structure and function and dauer formation and recovery; has WD40 repeat motifs G-beta-repeats; che-2 encodes a protein that contains G-protein beta-like WD-40 repeats that affects chemotaxis, dauer formation, and longevity; expressed in the cilia of most ciliated sensory neurons, some head neurons, and male tail rays. F38G1.2 egl-17;F38G1.2 Member of the fibroblast growth factor family required for sex-myoblast migration and egg laying The egl-17 gene encodes a fibroblast growth factor-like protein that is expressed in the gonadal cells required to attract the sex myoblasts to their precise final positions. F38H12.1 F38H12.1 Member of the 7-transmembrane chemoreceptor family of G protein-coupled receptors (GPCR), has a region of weak similarity to C. elegans STR-2 7TM chemoreceptor, srj family F38H12.2 srj-40;F38H12.2 Member of the 7-transmembrane chemoreceptor family of G protein-coupled receptors (GPCR), has high similarity to uncharacterized C. elegans T02B11.5 7TM chemoreceptor, srj family F38H12.3 F38H12.3 Protein containing a nuclear hormone receptor C4-type zinc finger domain, which bind DNA and may help regulate transcription, and a nuclear hormone receptor ligand-binding domain, has low similarity to hepatocyte nuclear factor 4 gamma (mouse Hnf4g) nuclear hormone receptor F38H12.5 F38H12.5 Protein containing a DUF40 domain of unknown function, which contain four conserved cysteines F38H4.1 F38H4.1 Protein of unknown function, has weak similarity to C. elegans T24H10.5 F38H4.10 F38H4.10 Protein with moderate similarity to S. pombe Mob1p, which is an essential protein involved in cytokinesis and septum formation Yeast hypothetical protein YIK6 like F38H4.2 F38H4.2 Member of an uncharacterized protein family This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins; its encoded protein also contains a Pfam-B45 motif of presently unknown function. F38H4.3 F38H4.3 Protein of unknown function F38H4.4 F38H4.4 Member of the protein-tyrosine phosphatase family, which are involved in control of cell growth, proliferation, and differentiation, has a region of low similarity to a region of human PTPN1, which is a non-receptor type protein tyrosine phosphatase protein tyrosine phosphatase F38H4.5 F38H4.5 Protein of unknown function, has moderate similarity to uncharacterized C. elegans ZK1307.1 F38H4.6 F38H4.6 Protein containing a major sperm protein (MSP) domain, which are involved in sperm motility, has moderate similarity to uncharacterized C. elegans F57A10.2 F38H4.7 F38H4.7 Protein containing a BTB (BR-C, ttk and babor) or POZ (Pox virus and zinc finger) domain, which are found in some DNA and actin binding proteins and may mediate protein-protein interactions, has a region of low similarity to a region of C. elegans KEL-1 BTB (also known as BR-C/Ttk) domain. F38H4.8 F38H4.8 Member of the enoyl-CoA hydratase or isomerase family, has low similarity to short chain enoyl-Coenzyme A hydratase 1 (rat Echs1), which catalyzes the hydration of trans-2-enoyl-CoA forming 3-hydroxyacyl-CoA in fatty acid beta-oxidation enoyl-CoA hydratase F38H4.9 PP2A-C;F38H4.9 Protein with strong similarity to rat Ppp2cb, which is the catalytic subunit of protein phosphatase 2A thought to play a regulatory role in many cellular pathways, member of the serine or threonine protein phosphatase family serine/threonine protein phosphatase; let-92 encodes a homolog of PP2AC, the catalytic subunit of protein phosphatase 2A (PP2A), identified genetically in screens for essential genes on chromosome IV; LET-92 may regulate a number of signal transduction pathways as it is required for embryogenesis, larval development, Ras-mediated vulval development, and axonal guidance in the DD and VD neurons; let-92 interacts genetically with sur-6 which encodes a regulatory subunit of PP2A; LET-92 protein is bound both by SMG-2 and by POS-1, and also interacts in vitro with UNC-51 and UNC-14; LET-92 is expressed cytoplasmically in nearly all cells and strongly in many neurons. F39B1.1 F39B1.1 Protein containing phosphatidylinositol 3- and 4-kinase, phosphoinositide 3-kinase C2, phox protein (PX), C2, and PIK domains, and a ubiquitin interaction motif, has low similarity to phosphoinositide-3-kinase class 2 alpha polypeptide (human PIK3C2A) phosphatidylinositol 3-kinase like F39B2.1 F39B2.1 Protein containing nine C2H2 type zinc finger domains, has weak similarity to a region of S. cerevisiae Zap1p, which is a zinc-responsive transcriptional activator that regulates genes involved in zinc uptake Zinc finger, C2H2 type (7 domains) F39B2.10 F39B2.10 Protein with high similarity to DnaJ homolog subfamily A member 1 (human DNAJA1), which is a heat shock protein that acts as a cochaperone, contains a DnaJ domain, a cysteine-rich DnaJ central domain, and a DnaJ C-terminal domain DnaJ, prokaryotic heat shock protein; This gene encodes a protein containing a DnaJ ('J') domain. F39B2.11 F39B2.11 Protein with low similarity to metaxin (mouse Mtx), which is an outer mitochondrial membrane protein that plays a role in protein import and is required for embryonic development F39B2.2 F39B2.2 Protein with high similarity to ubiquitin-conjugating E2 enzyme variant 2 (human UBE2V2), which may regulate differentiation, member of the ubiquitin-conjugating enzyme (E2) family, which catalyze the covalent attachment of ubiquitin to target proteins uev-1 encodes a ubiquitin-conjugating enzyme (UBC or E2) variant that contains the characteristic UBC motif, but lacks the critical active-site cysteine residue necessary for catalytic activity; as loss of UEV-1 function via RNA-mediated interference (RNAi) does not result in any abnormalities, the precise role of UEV-1 in C. elegans development and/or behavior is not yet known; UEV-1 does, however, interact with a number of proteins, such as UBC-13, that are likely involved in the response to DNA damage; thus, UEV-1 may play a role in ubiquitination and protein turnover in conjunction with DNA repair or the DNA damage checkpoint pathway. F39B2.3 F39B2.3 Member of the alcohol dehydrogenase protein family Zinc-binding dehydrogenases F39B2.4 sur-2;mpk-2;F39B2.4 Putative downstream component of let-60 ras pathway; involved in vulval induction SUR-2 PROTEIN F39B2.5 F39B2.5 Protein containing one Src homology 2 (SH2) domain, which are regulatory modules of intracellular signaling Src homology domain 2 F39B2.6 F39B2.6 Member of the ribosomal protein S26 protein family 40S ribosomal protein S26; rps-26 encodes a small ribosomal subunit S26 protein; by homology, RPS-26 is predicted to function in protein biosynthesis; in C. elegans, RPS-26 activity is required for embryonic, larval, and germline development, as well as normal locomotion and body morphology. F39B2.7 F39B2.7 Member of an uncharacterized GTPase family, has low similarity to S. cerevisiae Mss1p, which is a mitochondrial GTPase involved in expression of S. cerevisiae Cox1p (Oxi3p) This gene encodes a protein predicted by Eisenberg and coworkers, with 68% accuracy, to be mitochondrial. F39B2.8 F39B2.8 Protein of unknown function F39B2.9 F39B2.9 Protein of unknown function F39B3.1 F39B3.1 Member of the rhodopsin family of G-protein coupled receptors (GPCR) F39B3.2 F39B3.2 Protein of unknown function F39B3.3 F39B3.3 Putative ortholog of C. elegans T03F1.4 gene product F39C12.1 F39C12.1 Protein of unknown function, has moderate similarity to H. sapiens Hs.169504 gene product F39C12.2 add-1;F39C12.2 Protein containing three Class II aldolase domains, has low similarity to alpha adducin (human ADD1), which is an adducin complex subunit that may promote spectrin-actin complex assembly, regulate ion transport, and be associated with hypertension add-1 encodes an ortholog of the cytoskeletal protein alpha-adducin (ADD1, OMIM:102680, mutations are associated with susceptibility to salt-sensitive essential hypertension); by homology, ADD-1 is predicted to be a cell membrane-associated protein that mediates localized changes in the cytoskeleton in response to activation of signal transduction cascades; as loss of add-1 activity via large-scale RNAi screens does not result in any obvious abnormalities, the precise role of ADD-1 in C. elegans development and/or behavior is not yet known. F39C12.3 F39C12.3 Member of the tetraspanin family, which contain an N-terminal transmembrane domain that is a signal sequence and membrane anchor, has a region of low similarity to a region of CD53 antigen (mouse Cd53), which is a pan-leukocyte cell surface antigen transpanin F39D8.1 F39D8.1 Protein of unknown function The protein product of this gene is predicted to contain a glutamine/asparagine (Q/N)-rich ('prion') domain, by the algorithm of Michelitsch and Weissman (as of the WS77 release of WormBase, i.e., in wormpep77). F39D8.2 F39D8.2 Protein with weak similarity to H. sapiens PKNOX1 (PBX/knotted 1 homeobox 1) F39D8.3 F39D8.3 Protein with moderate similarity to C. elegans Y95B8A.6 gene product carbonic anhydrase like F39D8.4 F39D8.4 Member of the astacin (M12A) family of metalloproteases, has a region of moderate similarity to a region of meprin A beta subunit (mouse Mep1b), which is an integral membrane protein that forms a meprin A heterodimer with alpha subunit Mep1a metalloprotease F39E9.1 F39E9.1 Protein with strong similarity to C. elegans Y46D2A.2 gene product F39E9.10 F39E9.10 Protein of unknown function F39E9.2 F39E9.2 Protein containing four BTB (BR-C, ttk and babor) or POZ (Pox virus and zinc finger) domains, which are found in some DNA and actin binding proteins and may mediate protein-protein interactions F39E9.3 F39E9.3 Member of the 7-transmembrane chemoreceptor family of G protein-coupled receptors (GPCR), has high similarity to uncharacterized C. elegans F34D6.5 7TM chemoreceptor, sri family F39E9.4 F39E9.4 Member of the M13 peptidase family of zinc metalloproteases, has weak similarity to endothelin-converting enzyme 1 (human ECE1), which is a zinc metalloprotease that generates the endothelin vasoconstrictors and is associated with Hirschsprung disease peptidase; F39E9.4 encodes a neprilysin; neprilysins are thermolysin-like zinc metallopeptidases, found on the outer surface of animal cells, that negatively regulate small signalling peptides (e.g., enkephalin, tachykinin, insulin, and natriuretic peptides) by cleaving them; F39E9.4 has no clear orthologs in other organisms. F39E9.5 F39E9.5 Protein of unknown function, has high similarity to uncharacterized C. elegans Y59E1A.3 mariner transposase F39E9.6 F39E9.6 Protein of unknown function, has weak similarity to C. elegans F18A12.6 F39E9.6 encodes a neprilysin; neprilysins are thermolysin-like zinc metallopeptidases, found on the outer surface of animal cells, that negatively regulate small signalling peptides (e.g., enkephalin, tachykinin, insulin, and natriuretic peptides) by cleaving them; F39E9.6 has no clear orthologs in other organisms. F39E9.7 F39E9.7 Protein containing a double-stranded RNA binding domain F39F10.1 F39F10.1 Protein of unknown function F39F10.2 F39F10.2 Protein containing a protein kinase domain, has low similarity to S. pombe Hhp1p, which is a putative casein kinase I (CKI) that is required for DNA repair serine/threonine-protein kinase F39F10.3 F39F10.3 Protein containing a protein kinase domain, has a region of low similarity to a region of S. pombe Hhp2p, which is a casein kinase I homolog serine/threonine-protein kinase F39F10.4 F39F10.4 Protein of unknown function F39F10.5 F39F10.5 Protein with strong similarity to C. elegans C08A9.5 gene product F39G3.1 F39G3.1 Protein containing a UDP-glucoronosyl and UDP-glucosyl transferase domain, has low similarity to UDP glycosyltransferase 2 family polypeptide B7 (human UGT2B7), which glucuronidates androgens, retinoids, lipids and specific drugs UDP-glucosyltransferase F39G3.2 F39G3.2 Protein of unknown function, has moderate similarity to uncharacterized C. elegans E03H4.5 F39G3.3 F39G3.3 Protein with weak similarity to H. sapiens Hs.198760 (Homo sapiens mRNA for KIAA0845 protein, partial cds) F39G3.4 F39G3.4 Protein of unknown function, has high similarity to uncharacterized C. elegans F39G3.5 F39G3.5 F39G3.5 Protein of unknown function, has high similarity to uncharacterized C. elegans F39G3.4 F39G3.6 F39G3.6 Protein containing a DUF33 domain of unknown function, has high similarity to uncharacterized C. elegans Y67A10A.1 F39G3.7 prx-6;pex6;pex-6;F39G3.7 Member of the proteasome complex protein family ATPase F39G3.8 F39G3.8 Protein containing one transforming growth factor beta-like domain and one transforming growth factor beta (TGFb) propeptide domain, has low similarity to bone morphogenetic protein 2 (human BMP2), which is involved in development The tig-2 gene, like dbl-1, daf-7, and unc-129, encodes a TGF-beta-like protein. F39H11.1 F39H11.1 Protein of unknown function, has low similarity to uncharacterized craniofacial development protein 1 (mouse Cfdp), which may play a role in embryogenesis Yeast YB81 protein like F39H11.2 tlf-1;tif-1;tlp-1;TLF;F39H11.2 Has similarity to TATA-binding protein (TBP) transcription factors; required for the initiation of transcription of many or all genes during embryogenesis and appropriate development transcription factor TFIID like; The tlf-1 gene encodes a TATA binding protein (TBP)-like factor (TLF-1); TLF-1 is a functional transcriptional factor, and is required in vivo for zygotic embryonic RNA polymerase II transcription. F39H11.3 F39H11.3 Protein containing a protein kinase domain, has low similarity to S. cerevisiae Slt2p, which is a serine/threonine protein kinase involved in the cell wall integrity (low-osmolarity) pathway serine/threonine kinase; cdk-8 encodes a member of the cyclin-dependent serine/threonine protein kinase family orthologous to human CDK8 (OMIM:603184) which functions in transcriptional regulation with the positive regulatory factor cyclin C, is associated with the RNA polymerase II holoenzyme, and may regulate gene-specific activators; CDK-8 also contains a glutamine/asparagine-rich domain; loss of cdk-8 function via RNA-mediated interference (RNAi) results in sterility in the injected hermaphrodite, suggesting that in C. elegans, CDK-8 may play a role in germ-line development. F39H11.4 cle-1;C36B1.1;C36B1.2;F39H11.4 Contains a putative fibronectin type-III domain; weakly similar over the N-terminal half to human neogenin (NEO1) and fibronectin (FN1) and the C. elegans UNC-40 receptor F39H11.5 pbs-7;F39H11.5 Putative beta-type subunit of 20S proteasome particle Yeast NIP80 protein like; pbs-7 encodes a B-type subunit of the 26S proteasome's 20S protease core particle; by homology, PBS-7 is predicted to function in ATP/ubiquitin-dependent nonlysosomal protein degradation; loss of pbs-7 activity via large-scale RNAi screens indicates that, in C. elegans, PBS-7 is required for normal movement and for embryonic, germline, and larval development. F39H12.1 F39H12.1 Putative coiled-coil protein, has weak similarity to S. cerevisiae Uso1p F39H12.2 F39H12.2 Protein of unknown function F39H12.3 F39H12.3 Member of the regulatory subunit of type II protein kinase A R-subunit family, which interact with A-kinase anchoring proteins, contains three IQ calmodulin-binding domains F39H12.4 F39H12.4 Protein with strong similarity to D. melanogaster CG3390 (CG3390 gene product) F39H2.1 F39H2.1 Protein of unknown function, has a region of low similarity to a region of DNA cross-link repair protein (human DCLRE1A), which is a nuclear protein involved in repair of DNA interstrand crosslinks F39H2.2 F39H2.2 Member of the cyclophilin type peptidyl-prolyl cis-trans isomerase family, contains an RNA recognition motif (RRM, RBD, or RNP), has weak similarity to cyclophilin (peptidylprolyl cis-trans isomerase or PPIase, S. cerevisiae Cpr7p) peptidylprolyl isomerase; cyp-14 encodes a predicted cyclophilin. F39H2.3 F39H2.3 Protein of unknown function, has low similarity to uncharacterized S. pombe Spac21e11.07p S.pombe hypothetical protein C21E11.07 like; This gene encodes a protein predicted by Eisenberg and coworkers, with 68% accuracy, to be mitochondrial. F39H2.4 F39H2.4 Protein of unknown function F40A3.1 F40A3.1 Protein of unknown function F40A3.2 F40A3.2 Protein with weak similarity to C. elegans F35D2.3, a protein containing EGF-like domains F40A3.3 F40A3.3 Protein with high similarity to phosphatidylethanolamine binding protein (rat Pbp), which enhances acetylcholine synthesis and function in organizing sperm membranes during spermatogenesis, member of the phosphatidylethanolamine-binding protein family phosphatidylethanolamine binding protein F40A3.4 F40A3.4 Protein of unknown function F40A3.5 F40A3.5 Protein containing a protein kinase domain, has low similarity to a region of avian erythroblastosis oncogene B 4 (human ERBB4), which is a receptor tyrosine kinase that plays a role in cell migration, proliferation and differentiation protein kinase F40A3.6 F40A3.6 Protein of unknown function F40A3.7 srq-2;F40A3.7 Member of the rhodopsin family of G protein-coupled receptors (GPCR), has moderate similarity to uncharacterized C. elegans SRQ-1 F40B1.1 F40B1.1 Protein containing a meprin and TRAF homology (MATH) domain, and a BTB (BR-C, ttk and babor) or POZ (Pox virus and zinc finger) domain, which may mediate protein-protein interactions, has high similarity to uncharacterized C. elegans F59H5.3 F40B1.2 F40B1.2 Protein containing a BTB or POZ domain, which are found in some DNA and actin binding proteins and may mediate protein-protein interactions, and a meprin and TRAF homology (MATH) domain, has high similarity to uncharacterized C. elegans F40B1.1 F40B5.1 F40B5.1 Member of the M13 peptidase family of zinc metalloproteases, has low similarity to uncharacterized C. elegans C53B7.7 F40B5.1 encodes a neprilysin; neprilysins are thermolysin-like zinc metallopeptidases, found on the outer surface of animal cells, that negatively regulate small signalling peptides (e.g., enkephalin, tachykinin, insulin, and natriuretic peptides) by cleaving them; F40B5.1 has no clear orthologs in other organisms. F40B5.2 F40B5.2 Protein of unknown function, has low similarity to uncharacterized C. elegans T23G7.2 F40B5.3 F40B5.3 Protein with strong similarity to C. elegans C53B7.7 gene product F40B5.3 encodes a neprilysin; neprilysins are thermolysin-like zinc metallopeptidases, found on the outer surface of animal cells, that negatively regulate small signalling peptides (e.g., enkephalin, tachykinin, insulin, and natriuretic peptides) by cleaving them; F40B5.3 has no clear orthologs in other organisms. F40C5.1 F40C5.1 Protein of unknown function, putative paralog of C. elegans T24A6.16 F40C5.2 F40C5.2 Protein of unknown function, has moderate similarity to C. elegans T24A6.17 F40C5.3 F40C5.3 Protein of unknown function, has strong similarity to C. elegans T24A6.15 F40D4.1 F40D4.1 Member of the 7-transmembrane chemoreceptor family of G protein-coupled receptors (GPCR), has high similarity to uncharacterized C. elegans F20E11.11 F40D4.10 F40D4.10 Protein containing a DUF216 domain of unknown function, has high similarity to uncharacterized C. elegans F40D4.9 F40D4.11 F40D4.11 Member of the 7-transmembrane chemoreceptor family of G protein-coupled receptors (GPCR), has high similarity to uncharacterized C. elegans F21H7.11 G-protein coupled receptor, srh family F40D4.12 F40D4.12 Protein containing an F-box domain, which serve as a link between a target protein, and a ubiquitin-conjugating enzyme and a DUF38 domain of unknown function, has low similarity to uncharacterized C. elegans F58E2.3 F40D4.13 F40D4.13 Putative ortholog of C. elegans T11F9.10 gene product F40D4.2 F40D4.2 Member of the 7-transmembrane chemoreceptor family of G protein-coupled receptors (GPCR), has strong similarity to uncharacterized C. elegans F20E11.12 F40D4.3 F40D4.3 Member of the 7-transmembrane chemoreceptor family of G protein-coupled receptors (GPCR), has high similarity to uncharacterized C. elegans F20E11.3 F40D4.4 F40D4.4 Member of the 7-transmembrane chemoreceptor family of G protein-coupled receptors (GPCR) F40D4.5 F40D4.5 Protein of unknown function, has high similarity to uncharacterized C. elegans F20E11.2 F40D4.6 F40D4.6 Protein containing a DUF40 domain of unknown function, which contain four conserved cysteines, has high similarity to uncharacterized C. elegans F40D4.7 7TM receptor, srbc family F40D4.7 F40D4.7 Protein containing a DUF40 domain of unknown function, which contain four conserved cysteines, has high similarity to uncharacterized C. elegans F40D4.6 7TM receptor, srbc family F40D4.8 F40D4.8 Protein of unknown function, has high similarity to uncharacterized C. elegans M01B2.5 7TM chemoreceptor, srw family F40D4.9 F40D4.9 Protein containing a DUF216 domain of unknown function, has high similarity to uncharacterized C. elegans F40D4.10 F40E10.1 hch-1;F40E10.1 Putative zinc-dependent metalloprotease, putative paralog of C. elegans K04E7.3, a member of the CUB domain protein family metalloprotease; hch-1 encodes a member of the zinc-dependent metalloprotease family that contains an epidermal growth factor-like domain, a CUB domain, and a TSP1 domain and affects hatching and QL neuroblast migration. F40E10.2 F40E10.2 Protein containing a high mobility group box (HMG1 or 2) family domain, has a region of strong similarity to a region of SRY box 2 (human SOX2), which is a transcriptional activator that exists as a tumor antigen in small cell lung cancer sex-determining protein SOX3 like F40E10.3 csq-1;F40E10.3 Protein with strong similarity to human CASQ2 protein, a cardiac muscle calsequestrin 2 calsequestrin like F40E10.5 F40E10.5 Protein containing a DUF148 domain of unknown function F40E10.6 F40E10.6 Protein of unknown function F40E12.1 F40E12.1 Protein of unknown function F40E12.2 F40E12.2 Protein containing a BRCA1 (breast cancer type 1) C terminus (BRCT) domain, which are found in some cell cycle checkpoint proteins, an ankyrin (Ank) repeat, which may mediate protein-protein interactions and a WSN domain of unknown function F40E3.2 F40E3.2 Protein with moderate similarity to C. elegans Y23H5A.1 gene product F40E3.3 F40E3.3 Protein of unknown function F40E3.5 F40E3.5 Member of the serine or threonine protein phosphatase family, has low similarity to mouse Ppp1cc, which is the catalytic subunit of protein phosphatase 1 and which functions in cellular signal transduction and is required for normal sperm fertility serine threonine protein phosphatase F40E3.6 F40E3.6 Putative ortholog of C. elegans F59H6.2 gene product F40F11.1 F40F11.1 Member of the ribosomal protein S11 protein family ribosomal protein S11; rps-11 encodes a small ribosomal subunit S11 protein; by homology, RPS-11 is predicted to function in protein biosynthesis; in C. elegans, RPS-11 activity is required for embryonic and germline development, as well as the overall health of the animal. F40F11.2 F40F11.2 Protein with weak similarity to C. elegans unc-89, a muscle cell protein of the immunoglobulin-like protein family that is required for coordinated locomotion F40F11.3 F40F11.3 Protein of unknown function F40F11.4 F40F11.4 Protein with weak similarity to H. sapiens LRP1 (low density lipoprotein-related protein 1 (alpha-2-macroglobulin receptor)) F40F12.1 F40F12.1 Member of the transthyretin-like family, has very strong similarity to uncharacterized C. elegans K03H1.3 Transthyretin-like family F40F12.2 F40F12.2 Member of the reverse transcriptase family, which are RNA-dependent DNA polymerases, has a region of weak similarity to a region of LINE retrotransposable element 1 (human LRE1), which is a reverse transcriptase and endonuclease Reverse transcriptase F40F12.3 F40F12.3 Protein with moderate similarity to C. elegans C07A9.6 gene product F40F12.4 F40F12.4 Protein of unknown function, has weak similarity to C. elegans H03G16.2 F40F12.5 F40F12.5 Putative ortholog of C. elegans F40F12.6 gene product Ubiquitin carboxyl-terminal hydrolases family 2; F40F12.5 is orthologous to the human gene CYLINDROMATOSIS (TURBAN TUMOR SYNDROME) (CYLD; OMIM:605018), which when mutated leads to disease. F40F12.7 F40F12.7 Protein containing a transcriptional adaptor putative zinc finger (TAZ) domain, which may bind transcriptional activators and repressors, has high similarity to a region of C. elegans CBP-1, which is a transcriptional activator F40F4.1 F40F4.1 Protein containing an F-box domain, which serve as a link between a target protein and a ubiquitin-conjugating enzyme, has moderate similarity to uncharacterized C. elegans H24O09.2 This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins; its encoded protein also contains a Pfam-B45 motif of presently unknown function. F40F4.2 lbp-2;F40F4.2 Protein of unknown function, has high similarity to uncharacterized C. elegans LBP-1 fatty acid-binding protein; lbp-2 encodes a homolog of the novel fatty acid binding protein, As-p18, found in the parasitic nematode Ascaris suum; As-p18 is a member of a family of small intracellular fatty acid binding proteins (iFABPs); the expression pattern of lpb-2 is consistent with it being secreted into the perienteric fluid where it may play a role in lipid transport beween the intestine and body wall; a lbp-2 promoter::gfp fusion reporter is restricted to body wall muscle cells abutting the pseudocoelom. F40F4.3 lbp-1;F40F4.3 Fatty acid-binding protein homolog 2 of unknown function fatty acid-binding protein F40F4.4 lbp-3;F40F4.4 Member of the lipocalin and cytosolic fatty-acid binding protein family, has high similarity to uncharacterized C. elegans LBP-4 F40F4.5 F40F4.5 Protein with strong similarity to alpha tubulin (C. elegans MEC-12), which is required in mechanosensory neurons, member of the tubulin-FtzA family, which are involved in polymer formation tubulin beta chain; tba-9 encodes one of nine C. elegans alpha tubulins; by homology, TBA-9 is predicted to be a component of microtubules; as loss of tba-9 function via RNA-mediated interference (RNAi) does not result in any obvious abnormalities, TBA-9 likely functions redundantly with other alpha tubulins as a basic component of cellular architecture that may play additional roles in processes such as cell division, cell movement, and intracellular transport. F40F4.6 F40F4.6 Member of the EGF-repeat protein family, member of the C-type lectin family EGF-like repeats F40F4.7 F40F4.7 Protein containing an acetyltransferase (GNAT) domain F40F4.8 F40F4.8 Protein of unknown function The protein product of this gene is predicted to contain a glutamine/asparagine (Q/N)-rich ('prion') domain, by the algorithm of Michelitsch and Weissman (as of the WS77 release of WormBase, i.e., in wormpep77). F40F8.1 F40F8.1 Protein with high similarity to UMP-CMP kinase (human UMP-CMPK), which phosphorylates nucleotide and deoxynucleotide phosphates and chemotherapeutic deoxycytidine analogs, member of the adenylate kinase family UMP-CMP kinase like; This gene encodes a protein predicted by Eisenberg and coworkers, with 52% accuracy, to be mitochondrial. F40F8.10 F40F8.10 Protein with high similarity to ribosomal protein S9 (S. cerevisiae Rps9Bp), contains a ribosomal S4 or S9 N-terminal domain, which are present in the small ribosomal subunit, contains an S4 domain, which may bind RNA ribosomal protein S9; rps-9 encodes a small ribosomal subunit S9 protein. F40F8.3 F40F8.3 Protein of unknown function F40F8.4 F40F8.4 Protein of unknown function F40F8.5 F40F8.5 Protein with moderate similarity to C. elegans F44E2.8 gene product F40F8.7 pqm-1;CePqM132;F40F8.7 Protein containing two C2H2 type zinc finger domains, which bind nucleic acids Zinc finger, C2H2 type; pqm-1 encodes a C2H2-type zinc finger and leucine zipper-containing protein that is upregulated in response to oxidative stress induced by paraquat treatment; PQM-1 may function as a stress-responsive transcription factor. F40F8.8 F40F8.8 Protein of unknown function, has a region of weak similarity to vitamin D-3 upregulated protein-1 (mouse Txnip), which is a thioredoxin binding protein induced by oxidative stress that inhibits thioredoxin activity F40F8.9 F40F8.9 Member of the Sm family, which are core constituents of snRNP complexes, has a region of high similarity to a region of S. cerevisiae Lsm1p, which is involved in control of mRNA decay Yeast J0714 like F40F9.1 F40F9.1 Protein containing one uncharacterized UPF0005 domain, has moderate similarity to neural membrane protein 35 (lifeguard, human NMP35), which binds the Fas receptor (TNFRSF6) and inhibits Fas receptor-induced apoptosis N-methyl-D-aspartate receptor associated protein F40F9.10 F40F9.10 Member of the Met-10+-like protein family, which may be involved in methionine biosynthesis, transport or utilization F40F9.11 F40F9.11 Member of the 7-transmembrane chemoreceptor family of G protein-coupled receptors (GPCR), has weak similarity to C. elegans ODR-10, which is involved in odorant response F40F9.2 F40F9.2 Protein containing one uncharacterized domain UPF0005, has moderate similarity to a region of neural membrane protein 35 (lifeguard, human NMP35, which binds the Fas receptor (TNFRSF6) and inhibits Fas receptor-induced apoptosis N-methyl-D-aspartate receptor associated protein; tag-120 encodes a predicted transmembrane protein; as loss of tag-120 activity via RNAi does not result in any abnormalities, the precise role of TAG-120 in C. elegans development and/or behavior is not yet known; however, TAG-120 is homologous to a Drosophila NMDA receptor-associated protein and mammalian transmembrane proteins that function in Fas-mediated cell death, so TAG-120 may play a role in neuronal functions and/or apoptosis; a tag-120 reporter fusion is expressed in the nervous system, pharyngeal muscles, and to a lesser extent in the excretory system. F40F9.3 F40F9.3 Protein containing a PDZ, DHR, or GLGF domain, which are found in signaling proteins, has low similarity to a region of C. elegans C25G4.6, which is a protein required for spermatogenesis PDZ domain (Also known as DHR or GLGF). F40F9.4 F40F9.4 Member of the 7-transmembrane chemoreceptor family of G protein-coupled receptors (GPCR), has high similarity to uncharacterized C. elegans F26D10.8 F40F9.5 F40F9.5 Protein of unknown function, has weak similarity to C. elegans Y43F8A.E translocase F40F9.6 F40F9.6 Putative glycosyl hydrolase, possible ortholog of S. cerevisiae Rot2p, the catalytic subunit of glucosidase II glycosyl hydrolase F40F9.7 F40F9.7 Protein of unknown function, has a region of moderate similarity to a region of DR1-associated protein 1 (negative cofactor 2 alpha, human DRAP1), which is a transcription factor that blocks RNA polymerase II transcription initiation F40F9.8 F40F9.8 Protein with low similarity to calmodulin 1 (human CALM1), which regulates the calcium-dependent activity of proteins and enzymes including ion channels, kinases, phosphatases, and phosphodiesterases EF-hand calcium binding protein F40F9.9 aqp-Ce2;F40F9.9 Mercury-sensitive water channel protein with similarity to MIP (major intrinsic proteins) proteins; has strong similarity to C. elegans C32C4.2 MIP transmembrane protein F40G12.1 F40G12.1 Member of the C. elegans Sre G protein-coupled chemoreceptor family, which are putative chemosensory receptors, has high similarity to uncharacterized C. elegans K02E11.2 7TM receptor, sre family F40G12.10 F40G12.10 Member of the protein-tyrosine phosphatase family, which are involved in control of cell growth, proliferation, differentiation and transformation, has a region of weak similarity to a region of mouse Ptpra, which is a receptor tyrosine phosphatase protein-tyrosine phosphatase F40G12.11 F40G12.11 Protein of unknown function F40G12.2 F40G12.2 Protein with moderate similarity to C. elegans C12D5.10 gene product F40G12.3 F40G12.3 Protein containing a sushi or short consensus repeat (SCR) domain, which are found in complement and adhesion proteins, has low similarity to uncharacterized C. elegans F59A6.3 Sushi domain F40G12.4 F40G12.4 Protein of unknown function, has moderate similarity to uncharacterized C. elegans F40G12.5 F40G12.5 F40G12.5 Protein of unknown function, has moderate similarity to uncharacterized C. elegans F40G12.4 F40G12.6 F40G12.6 Protein with strong similarity to C. elegans R13D7.2 gene product F40G12.7 F40G12.7 Protein with strong similarity to C. elegans F14D7.1 gene product F40G12.8 F40G12.8 Protein containing two DUF32 domains of unknown function, has low similarity to uncharacterized C. elegans F47D2.8 F40G12.9 F40G12.9 Protein with strong similarity to C. elegans T19H12.6 gene product F40G9.1 F40G9.1 Protein containing five ankyrin (Ank) repeats, which may mediate protein-protein interactions, has a region of high similarity to a region of gankyrin (rat Psmd10), which is an oncoprotein that induces growth and tumorigenicity F40G9.10 F40G9.10 Protein containing a C-type lectin domain, which mediate calcium-dependent carbohydrate recognition F40G9.11 F40G9.11 Protein containing a helix-loop-helix DNA-binding domain, which mediate protein dimerization F40G9.12 F40G9.12 Protein with moderate similarity to C. elegans F40G9.14 F40G9.13 F40G9.13 Protein containing a protein kinase domain, has moderate similarity to a region of fibroblast growth factor receptor 4 (human FGFR4), which is a receptor protein tyrosine kinase that preferentially binds acidic fibroblast growth factor F40G9.14 F40G9.14 Protein containing a putative C3HC4-type zinc finger domain, has strong similarity to C. elegans F40G9.12 zinc finger protein F40G9.2 F40G9.2 Protein with high similarity to cytochrome c oxidase assembly protein 17 (human COX17), which is a putative copper binding protein that may function to transport copper to the mitochondria for assembly into the cytochrome oxidase complex F40G9.3 F40G9.3 Protein with high similarity to huntingtin interacting protein 2 (human HIP2), which is a ubiquitin-conjugating enzyme, member of the ubiquitin-conjugating enzyme (E2) family ubiquitin conjugating enzyme F40G9.4 F40G9.4 Protein containing a BTB (BR-C, ttk and babor) or POZ (Pox virus and zinc finger) domain, which are found in some DNA and actin binding proteins and may mediate protein-protein interactions, has moderate similarity to uncharacterized C. elegans C08E3.2 F40G9.5 F40G9.5 Protein with moderate similarity to C. elegans K04F1.8 gene product F40G9.6 F40G9.6 Protein of unknown function F40G9.7 F40G9.7 Protein of unknown function F40G9.8 F40G9.8 Protein of unknown function, has moderate similarity to uncharacterized C. elegans T17A3.10 F40G9.9 F40G9.9 Protein with moderate similarity to C. elegans K12H6.7 and weak similarity to a region of C. elegans collagen LET-2 This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins. F40H3.1 F40H3.1 Protein of unknown function, has weak similarity to C. elegans F52H3.3 F40H3.2 F40H3.2 Protein of unknown function F40H3.3 F40H3.3 Protein of unknown function F40H3.4 F40H3.4 Protein containing a fork head domain, which are found in transcription factors involved in cell fate determination, has a region of moderate similarity to a region of C. elegans FKH-2, which is a putative transcription factor F40H3.5 F40H3.5 Member of the sulfotransferase family, has moderate similarity to heparan sulfate D-glucosaminyl 3-O-sulfotransferase (human HS3ST1), which is a key enzyme in biosynthesis of the anticoagulant form of heparan sulfate heparan sulfate sulfotransferase F40H3.6 F40H3.6 Protein of unknown function F40H6.1 F40H6.1 Protein of unknown function F40H6.2 F40H6.2 Putative ortholog of C. elegans F40H6.5 gene product F40H6.4 Ce-tbx-11;F40H6.4 Protein containing a T-box domain, which bind DNA, has a region of low similarity to C. elegans MAB-9, which is a transcriptional regulator involved in cell differentiation in the male tail, hermaphrodite rectum, and locomotory system tbx-11 encodes a T-box transcription factor that is orthologous to members of the Tbx2 subfamily of T-box transcription factors; by homology, TBX-11 is predicted to function in transcriptional regulation during cellular differentiation, potentially as both an activator and a repressor; however, as loss of tbx-11 function via large-scale RNAi screens does not result in any obvious abnormalities, the precise role of tbx-11 in C. elegans development and/or behavior is not yet known. F40H6.5 F40H6.5 Protein containing one DUF225 domain of unknown function F40H7.1 F40H7.1 Member of the G protein-coupled receptor protein family F40H7.10 F40H7.10 Protein of unknown function, has high similarity to uncharacterized C. elegans F40H7.2 F40H7.2 F40H7.2 Protein of unknown function, has high similarity to uncharacterized C. elegans C46E10.6 7TM chemoreceptor, srx family F40H7.3 F40H7.3 Protein of unknown function, has moderate similarity to uncharacterized C. elegans F19B10.7 F40H7.4 F40H7.4 Putative ortholog of C. elegans F40H7.3 gene product 7TM chemoreceptor, srx family F40H7.5 F40H7.5 Putative ortholog of C. elegans F40H7.4 gene product 7TM chemoreceptor, srx family F40H7.7 F40H7.7 Protein of unknown function, has high similarity to uncharacterized C. elegans F40H7.9 7TM chemoreceptor, srx family F40H7.8 F40H7.8 Protein of unknown function, has high similarity to uncharacterized C. elegans F40H7.1 7TM chemoreceptor, srx family F40H7.9 F40H7.9 Protein of unknown function, has high similarity to uncharacterized C. elegans F40H7.7 F41A4.1 F41A4.1 Protein containing three PAN domains, which may mediate protein-protein or protein-carbohydrate interactions F41A4.2 F41A4.2 Putative ortholog of C. elegans Y55F3C_751.C gene product F41B4.1 F41B4.1 Protein of unknown function F41B4.2 F41B4.2 Protein of unknown function, has high similarity to uncharacterized C. elegans F58E10.7 F41B4.3 F41B4.3 Protein of unknown function F41B4.4 glr-6;F41B4.4 Protein containing a ligand-gated ion channel domain, which are found in ionotropic glutamate and NMDA receptors, has low similarity to kainate-selective ionotropic glutamate receptor 2 (rat Grik2), which functions in excitatory neurotransmission ligand-gated ionic channel F41B5.10 F41B5.10 Protein containing a nuclear hormone receptor C4-type zinc finger domain and a nuclear hormone receptor ligand-binding domain, has moderate similarity to C. elegans NHR-58, which is involved in embryogenesis and morphogenesis nuclear hormone receptor F41B5.2 F41B5.2 Member of the cytochrome P450 family, has low similarity to cytochrome P450 subfamily 2E polypeptide 1 (rat Cyp2e1), which is a monooxygenase involved in xenobiotic, ethanol, and fatty acid metabolism, apoptosis, and oxidative stress cytochrome P450 F41B5.3 F41B5.3 Member of the cytochrome P450 family, has low similarity to cytochrome P450 subfamily 2C (mephenytoin 4-hydroxylase, rat Cyp2c), which is a male-specific liver enzyme responsible for gender-specific conversion of testosterone and drug metabolism cytochrome P450 F41B5.4 F41B5.4 Member of the cytochrome P450 family, has low similarity to cytochrome P450 2j4 (rat Cyp2j4), which is a monooxygenase that converts arachidonic acid to hydroxyeicosatetraenoic and epoxyeicosatrienoic acids cytochrome P450 F41B5.5 F41B5.5 Member of the cytochrome P450 family, has moderate similarity to uncharacterized C. elegans F41B5.2 F41B5.6 F41B5.6 Protein of unknown function, has high similarity to uncharacterized C. elegans Y87G2A.12 F41B5.7 F41B5.7 Member of the cytochrome P450 family, has low similarity to cytochrome P450 subfamily 2C polypeptide 8 (mephenytoin 4-hydroxylase, human CYP2C8), which is a heme-binding monooxygenase that metabolizes steroids, fatty acids, and xenobiotics cytochrome P450 F41B5.9 F41B5.9 Protein containing a nuclear hormone receptor C4-type zinc finger domain and a nuclear hormone receptor ligand-binding domain, has moderate similarity to C. elegans NHR-58, which is involved in embryogenesis and morphogenesis nuclear hormone receptor F41C3.1 F41C3.1 Protein with strong similarity to C. elegans ZK973_14.D gene product F41C3.11 F41C3.11 Protein of unknown function, has weak similarity to C. elegans ZK455.5 F41C3.2 F41C3.2 Protein with similarity to human and D. melanogaster sodium-dependent inorganic phosphate cotransporters, member of the major facilitator superfamily (MFS) Sodium/phosphate transporter protein F41C3.3 F41C3.3 Member of the AMP-binding enzyme family, has low similarity to S. cerevisiae Fat2p, which is a peroxisomal AMP-binding protein Long-chain-fatty-acid coA ligase F41C3.4 F41C3.4 Protein of unknown function, has high similarity to uncharacterized human LOC51026 F41C3.5 F41C3.5 Member of the serine carboxypeptidase family, has moderate similarity to protective protein for beta-galactosidase (cathepsin A, human PPGB), which is a serine carboxypeptidase that facilitates NEU1 transport and is associated with galactosialidosis Serine carboxypeptidase F41C3.6 F41C3.6 Protein of unknown function F41C3.7 F41C3.7 Protein of unknown function F41C3.8 F41C3.8 Protein of unknown function F41C6.1 unc-6;unc-106;F41C6.1 Laminin-related netrin protein of the epidermal basal lamina, required for guiding both dorsally- and ventrally-directed circumferential cell and axon migrations along the epidermis unc-6 encodes a netrin orthologous to the human and mouse netrin-1 precursor proteins; UNC-6 functions as a guidance molecule that regulates the migrations of pioneer axons and mesodermal cells, such as the gonadal distal tip cell, along the dorsoventral axis; a secreted molecule, UNC-6 is expressed during embryogenesis by epidermoblasts and neurons; UNC-6 is involved in both attractive and repulsive interactions that are mediated by the UNC-40 and UNC-5 netrin receptors, respectively. F41C6.2 F41C6.2 Putative ortholog of C. elegans T11F9.13 gene product F41C6.3 F41C6.3 Protein of unknown function, has very strong similarity to uncharacterized C. elegans T11F9.13 F41C6.4 F41C6.4 Protein with moderate similarity to C. elegans F40B5.1 gene product F41C6.5 F41C6.5 Protein containing two collagen triple helix repeats, which are found in some extracellular proteins, and a nematode cuticle collagen N-terminal domain, has a region of moderate similarity to a region of collagen type XI alpha 1 subunit (human COL11A1) cuticular collagen F41C6.6 F41C6.6 Protein of unknown function F41C6.7 F41C6.7 Protein of unknown function, has weak similarity to C. elegans F56C9.3 F41D3.1 nhr-82;F41D3.1 Member of the zinc finger protein family with similarity to nuclear hormone receptors Zinc finger, C4 type (two domains) F41D3.10 F41D3.10 Protein containing a DUF33 domain of unknown function, has very strong similarity to uncharacterized C. elegans F41D3.5 F41D3.11 F41D3.11 Protein of unknown function, has high similarity to uncharacterized C. elegans F46F5.14 F41D3.2 F41D3.2 Protein containing a DUF33 domain of unknown function, has high similarity to uncharacterized C. elegans F41D3.4 F41D3.3 F41D3.3 Protein containing a nuclear hormone receptor C4-type zinc finger domain and a nuclear hormone receptor ligand-binding domain, has high similarity to uncharacterized C. elegans NHR-A Zinc finger, C4 type (two domains) F41D3.4 F41D3.4 Protein containing a DUF33 domain of unknown function, has high similarity to uncharacterized C. elegans F41D3.2 F41D3.5 F41D3.5 Protein containing a DUF33 domain of unknown function, has very strong similarity to uncharacterized C. elegans F41D3.10 F41D3.6 F41D3.6 Member of the galectin family and the glycosyl transferase family 11, has a region of low similarity to a region of galectin (C. elegans LEC-1), which is a galactoside-binding lectin Vertebrate galactoside-binding lectins F41D3.7 F41D3.7 Protein with strong similarity to C. elegans F41D3.11 gene product F41D3.8 F41D3.8 Protein with moderate similarity to C. elegans C27C7.2 gene product F41D3.9 F41D3.9 Protein containing a DUF235 domain of unknown function, has high similarity to uncharacterized C. elegans T15D6.9 F41D9.1 F41D9.1 Protein containing one Src homology 3 (SH3) domain, which bind proline-rich peptides, one TBC domain, and one RUN domain, has a region of low similarity to a region of S. cerevisiae Mdr1p, which is a GTPase-activating protein F41D9.2 F41D9.2 Protein with moderate similarity to C. elegans C09F9.2 gene product F41D9.3 wrk-1;F41D9.3 Protein containing 11 immunoglobulin (Ig) domains, has low similarity to limbic system-associated membrane protein (rat Lsamp), which plays a role in the selective outgrowth of neurons and the targeting of axons F41D9.5 F41D9.5 Member of the sulfate transporter family, contains a sulphate transporter and antisigma factor antagonist (STAS) domain, has low similarity to diastrophic dysplasia sulfate transporter (solute carrier family 26 member 2, rat Slc26a2) sulfate permease F41E6.1 F41E6.1 Protein of unknown function F41E6.10 F41E6.10 Protein of unknown function F41E6.11 F41E6.11 Protein with weak similarity to H. sapiens Hs.139322 (Homo sapiens small proline-rich protein (SPRR3) gene, exons 1, 2, and 3 and complete cds) F41E6.12 F41E6.12 Protein of unknown function F41E6.13 F41E6.13 Protein containing four WD domains (WD-40 repeat), which may mediate protein-protein interactions, has moderate similarity to uncharacterized human DKFZP434J154 F41E6.14 F41E6.14 Protein containing a DUF33 domain of unknown function, has low similarity to uncharacterized C. elegans Y67A10A.1 F41E6.2 grd-5;F41E6.2 Protein of unknown function, has strong similarity to C. elegans GRD-10 grd-5 encodes a predicted secreted protein that is a member of the C. elegans groundhog gene family; by homology, GRD-5 is predicted to be involved in cell communication; loss of grd-5 activity via RNA-mediated interference (RNAi) can result in low levels of embryonic lethality, suggesting a possible role in embryogenesis; a grd-5 reporter gene is expressed in adults in anterior and posterior hypodermal seam cells, in a pattern that overlaps that of grd-3. F41E6.3 F41E6.3 Protein of unknown function, has moderate similarity to uncharacterized human KIAA1387 F41E6.4 F41E6.4 Protein of unknown function F41E6.5 F41E6.5 Member of the cytochrome b-like protein family glycolate oxidase F41E6.6 F41E6.6 Member of the papain family of cysteine proteases, contains a cystatin domain, has moderate similarity to cathepsin F (mouse Ctsf), which is a cysteine protease that is involved in processing of the major histocompatibility complex invariant chain cysteine protease and a protease inhibitor F41E6.7 F41E6.7 Protein of unknown function F41E6.8 F41E6.8 Protein of unknown function, has moderate similarity to C. elegans T13C5.2 F41E6.9 F41E6.9 Protein of unknown function, has high similarity to uncharacterized human HSPC177 F41E7.1 F41E7.1 Member of the sodium or hydrogen exchanger family, which maintain the pH of actively metabolizing cells, has high similarity to uncharacterized C. elegans F57G8.5 F41E7.2 F41E7.2 Protein with moderate similarity to C. elegans F57G8.5 gene product F41E7.3 F41E7.3 Member of the rhodopsin family of G protein-coupled receptors (GPCR), has low similarity to neuropeptide Y-Y2 receptor (mouse Npy2r), which signals through intracellular cAMP levels and calcium flux and regulates food intake and the stress response neurokinin receptor like F41E7.4 F41E7.4 Protein of unknown function F41E7.5 F41E7.5 Protein of unknown function collagen-like repeats F41E7.6 F41E7.6 Member of the choline or carnitine o-acyltransferase family, has low similarity to carnitine octanoyltransferase (rat COT), which catalyzes the conversion of branched and medium chain fatty acyl-CoA to the corresponding carnitine ester carnitine octanoyltransferase F41E7.7 F41E7.7 Protein of unknown function F41E7.8 F41E7.8 Protein of unknown function F41F3.1 F41F3.1 Protein of unknown function F41F3.2 F41F3.2 Protein containing a pleckstrin homology (PH) domain, which mediate protein-protein and protein-lipid interactions, has high similarity to uncharacterized suppressor of C. elegans CLR-1 (C. elegans SOC-1), which is an adaptor protein involved in signaling F41F3.3 F41F3.3 Protein of unknown function cuticlin F41F3.4 F41F3.4 Protein with high similarity to C. elegans DPY-16, which is a collagen, contains two collagen triple helix repeats, which are found in some extracellular proteins, and a nematode cuticle collagen N-terminal domain cuticle collagen F41F3.5 F41F3.5 Member of the rhodopsin family of G protein-coupled receptors (GPCR), has low similarity to uncharacterized C. elegans F59B1.5 F41F3.6 F41F3.6 Protein of unknown function, has high similarity to uncharacterized C. elegans F41F3.7 7TM chemoreceptor, srx family F41F3.7 F41F3.7 Protein of unknown function, has high similarity to uncharacterized C. elegans F41F3.6 7TM chemoreceptor, srx family F41G3.14 F41G3.14 Protein of unknown function F41G4.1 F41G4.1 Protein of unknown function, has moderate similarity to uncharacterized axonemal dynein light intermediate chain (human P28) F41G4.2 cah-1;F41G4.2 Member of the CAP (adenylate-cyclase associated) protein family, has a region of moderate similarity to adenylyl cyclase-associated protein 1 (human CAP), which binds actin and may function in regulation of cell growth, morphogenesis, and adenylyl cyclase adenylyl cyclase-associated protein; adenylyl cyclase-associated protein. F41G4.3 sto-5;F41G4.3 Member of the SPFH domain or Band 7 family, which may regulate cation conductance, has a region of high similarity to a region of C. elegans MEC-2, which is required for chemotaxis and function of touch receptors stomatin-like protein F41G4.4 F41G4.4 Putative ortholog of C. elegans ZC15.1 gene product F41G4.5 F41G4.5 Putative ortholog of C. elegans ZC15.1 gene product F41G4.7 F41G4.7 Putative ortholog of C. elegans F41G4.6 gene product F41G4.8 F41G4.8 Protein of unknown function F41H10.1 F41H10.1 Protein of unknown function, has very strong similarity to uncharacterized C. elegans C04F12.7 F41H10.10 F41H10.10 Protein containing a HORMA domain, which may recognize chromatin states, has low similarity to C. elegans HIM-3, which is a meiosis-specific protein localized to chromosome cores that may play a role in sister chromatid cohesion F41H10.11 F41H10.11 Protein of unknown function F41H10.12 F41H10.12 Protein of unknown function F41H10.2 F41H10.2 Protein with weak similarity to C. elegans T23H2.3 (Putative ortholog of human HuF2/TTF2, a RNA polymerase II termination factor) F41H10.3 F41H10.3 Protein of unknown function, has a region of low similarity to a region of C. elegans SDC-2, which directs the dosage compensation complex to the X chromosome in hermaphrodites F41H10.4 F41H10.4 Putative coiled-coil protein, has weak similarity to S. cerevisiae Uso1p, required for protein transport from ER to Golgi F41H10.5 F41H10.5 Protein of unknown function, has moderate similarity to uncharacterized C. elegans M02B1.3 F41H10.6 F41H10.6 Member of the histone deacetylase family, contains a Zn-finger in ubiquitin-hydrolases and other proteins domain, which have isopeptidase-T activity, has low similarity to histone deacetylase 6 (human HDAC6) F41H10.7 F41H10.7 Member of the GNS1 or SUR4 family of integral membrane proteins, has moderate similarity to polyunsaturated fatty acid (PUFA) elongase (C. elegans CEEl01), which contains the condensation activity required for fatty acid elongation integral membrane protein; The elo-5 gene encodes a paralog of elo-1 and elo-2, each of which encodes a polyunsaturated fatty acid (PUFA) elongase; ELO-5 is required for normally rapid growth and for normal fatty acid composition. F41H10.8 F41H10.8 Member of the GNS1 or SUR4 family of integral membrane proteins, has moderate similarity to polyunsaturated fatty acid (PUFA) elongase (C. elegans CEEl01), which contains the condensation activity required for fatty acid elongation The elo-6 gene encodes a paralog of elo-1 and elo-2, each of which encodes a polyunsaturated fatty acid (PUFA) elongase; ELO-6 may be required for a normally high growth rate. F41H10.9 F41H10.9 Protein of unknown function F41H8.1 F41H8.1 Protein of unknown function, has high similarity to uncharacterized C. elegans R13D11.3 F41H8.2 F41H8.2 Protein of unknown function, has high similarity to uncharacterized C. elegans R13D11.1 F41H8.3 F41H8.3 Putative ortholog of C. elegans R13D11.9 gene product F42A10.1 F42A10.1 Protein with high similarity to S. cerevisiae Gcn20p, which is a component of a protein complex required for activation of Gcn2p protein kinase in response to amino acid starvation, member of the ABC transporter family, which mediate membrane transport F42A10.2 F42A10.2 Member of the ezrin, radixin or moesin family, which link actin filaments to plasma membranes, contains two FERM domains, has low similarity to neurofibromin 2 (bilateral acoustic neuroma, merlin, schwannomin, human NF2) nfm-1 encodes a homolog of human merlin/schwannomin (NF2), which when mutated leads to neurofibromatosis, type 2 (OMIM:101000); at the same time, it is also homologous to the ERM family of cytoskeletal linkers with approximately equal similarity to ezrin, radixin and moesin. F42A10.3 F42A10.3 Member of the NNMT, PNMT or TEMT family of methyltransferases, has low similarity to indolethylamine N-methyltransferase (human INMT), which catalyzes the transfer of a methyl group from S-adenosyl-L-methionine to tryptamine and other indole compounds F42A10.4 efk-1;F42A10.4 Calcium/calmodulin dependent protein kinase efk-1 encodes a calcium/calmodulin-dependent protein kinase with homology to human elongation factor-2 kinase; expressed in only a few cells in embryos. F42A10.5 F42A10.5 Protein of unknown function F42A10.6 F42A10.6 Protein of unknown function, has high similarity to uncharacterized C. elegans F42A10.7 F42A10.7 F42A10.7 Protein of unknown function, has high similarity to uncharacterized C. elegans F42A10.6 F42A10.8 F42A10.8 Member of the astacin (M12A) family of metalloproteases, contains a CUB domain, which occurs extracellularly often in developmentally regulated proteins, has low similarity to a region of C. elegans HCH-1, which is likely a zinc-dependent metalloprotease F42A6.1 F42A6.1 Protein of unknown function, has strong similarity to uncharacterized C. elegans Y55H10A.2 F42A6.2 F42A6.2 Protein of unknown function F42A6.3 F42A6.3 Protein of unknown function, has high similarity to uncharacterized C. elegans F25D7.4 F42A6.4 F42A6.4 Member of the cytochrome P450 family, has low similarity to cytochrome P450 subfamily 3a polypeptide 11 (mouse Cyp3a11), which is a steroid-inducible microsomal enzyme that catalyzes oxidation of tetrahydrocannabinol compounds and activates aflatoxin B1 cytochrome P450 F42A6.5 F42A6.5 Protein containing one BRCA1 (breast cancer type 1) C terminus (BRCT) domain, which are found in some cell cycle checkpoint proteins F42A6.6 F42A6.6 Protein of unknown function F42A6.7 rbp-1;F42A6.7;CehnRNPA1;hrp-1 Protein with strong similarity to heterogeneous nuclear ribonucleoprotein (hnRNP) proteins, contains RNA recognition motif (RRM) domains RNA-binding protein; The hrp-1 gene encodes a homolog of the human DRPLA gene (OMIM:125370), which when mutated leads to dentatorubral-pallidoluysian atrophy or to Haw River syndrome (OMIM:140340). F42A6.8 F42A6.8 Protein containing a DUF38 domain of unknown function, has a region of moderate similarity to a region of C. elegans FOG-2, which is required for the sexual identity of germ cells F42A6.9 F42A6.9 Putative coiled-coil protein, has weak similarity to S. cerevisiae Uso1p, required for protein transport from ER to Golgi F42A8.1 F42A8.1 Protein with moderate similarity to C. elegans Y37D8A.3 gene product F42A8.2 F42A8.2 Protein with high similarity to S. cerevisiae Sdh2p, which is a succinate dehydrogenase (ubiquinone) iron-sulfur protein (Ip) subunit that functions in the TCA cycle, contains one 2Fe-2S iron-sulfur cluster binding domain succinate dehydrogenase (ubiquinone) iron sulphur protein; tag-55/F42A8.2 is orthologous to the human gene SUCCINATE DEHYDROGENASE COMPLEX, SUBUNIT B, IRON SULFUR PROTEIN (SDHB; OMIM:185470), which when mutated leads to extraadrenal pheochromocytoma; F42A8.2 protein is predicted to be mitochondrial. F42A8.3 F42A8.3 Protein of unknown function F42A9.1 F42A9.1 Putative diacylglycerol kinase, delta subunit kinase F42A9.2 lin-49;F42A9.2 Bromodomain protein functioning in hindgut development zinc-finger protein F42A9.3 F42A9.3 Protein of unknown function F42A9.4 F42A9.4 Member of the cytochrome P450 family, has moderate similarity to a region of cytochrome P450 subfamily 2C polypeptide 8 (mephenytoin 4-hydroxylase, human CYP2C8), which is a heme-binding monooxygenase that metabolizes steroids, fatty acids and xenobiotics F42A9.5 F42A9.5 Member of the cytochrome P450 family, has low similarity to cytochrome P450 subfamily 2c polypeptide 29 (mouse Cyp2c29), which is a major cannabinoid metabolizing enzyme in liver microsomes cytochrome P450 F42A9.6 F42A9.6 Protein of unknown function F42A9.7 F42A9.7 Protein with moderate similarity to C. elegans F53B6.4 gene product F42A9.8 F42A9.8 Protein of unknown function F42A9.9 F42A9.9 Protein of unknown function F42C5.10 F42C5.10 Protein of unknown function, has weak similarity to C. elegans T13A10.5 F42C5.2 F42C5.2 Member of the rhodopsin family of G protein-coupled receptors (GPCR), has low similarity to somatostatin receptor 2 (human SSTR2), which inhibits adenylyl cyclase and mediates inhibitory effects of human SST on cell proliferation and hormone secretion G protein-coupled receptor F42C5.3 F42C5.3 Protein of unknown function F42C5.4 F42C5.4 Protein of unknown function, has low similarity to uncharacterized C. elegans Y7A9C.1 F42C5.5 F42C5.5 Member of the protein-tyrosine phosphatase family, which are involved in control of cell growth, proliferation, differentiation and transformation F42C5.6 F42C5.6 Protein with moderate similarity to C. elegans F52A8.1 gene product F42C5.7 F42C5.7 Protein of unknown function containing a Ground-like domain, has moderate similarity to C. elegans C24G6.7 F42C5.8 F42C5.8 Protein with high similarity to ribosomal protein S8 (S. cerevisiae Rps8bp), which is a ribosomal structural protein, member of the ribosomal S8e family, which are part of the small ribosomal subunit 40S ribosomal protein S8; rps-8 encodes a small ribosomal subunit S8 protein; by homology, RPS-8 is predicted to function in protein biosynthesis; in C. elegans, RPS-8 activity is required for germline development and the overall health of the animal. F42C5.9 F42C5.9 Member of the actin family, which are major cytoskeletal proteins, has a region of low similarity to C. elegans ACT-2, which is involved in muscle contraction and synaptic transmission, F42D1.2 F42D1.2 Protein containing an aminotransferase class I and II domain, has moderate similarity to tyrosine aminotransferase (L-tyrosine:2-oxoglutarate aminotransferase, rat Tat), which converts L tyrosine to P-hydroxyphenylpyruvate and functions in gluconeogenesis tyrosine aminotransferase F42D1.3 F42D1.3 Protein of unknown function, has low similarity to uncharacterized C. elegans C35A5.7 G-protein coupled receptor F42E11.1 pgp-4;F42E11.1 P-glycoprotein, multidrug resistance protein of the ATP-binding cassette (ABC) superfamily, has strong similarity to human, Drosophila, and S. cerevisiae multidrug resistance proteins p-glycoprotein F42E11.2 F42E11.2 Protein of unknown function, has weak similarity to uncharacterized tweety homolog 1 (mouse Ttyh1) F42E11.3 F42E11.3 Protein of unknown function F42E11.4 F42E11.4 Member of the troponin family, which regulate calcium-induced muscle contraction, has high similarity to uncharacterized C. elegans T20B3.2 troponin I; tni-1 encodes a member of the troponin family that affects body morphology, locomotion, egg laying, and epithelial morphogenesis in a large-scale RNAi analysis. F42E8.1 F42E8.1 Protein of unknown function, has weak similarity to C. elegans T24H10.5 F42E8.2 F42E8.2 Protein containing a major sperm protein (MSP) domain, which are involved in sperm motility F42F12.1 F42F12.1 Protein of unknown function, has very strong similarity to uncharacterized C. elegans F42F12.6 F42F12.2 zig-2;F42F12.2 Protein containing two immunoglobulin (Ig) domains, which may be involved in protein-protein and protein-ligand interactions, has moderate similarity to uncharacterized C. elegans ZIG-3 IG-like C2-type domains F42F12.3 F42F12.3 Member of the 3-oxo-5-alpha-steroid 4-dehydrogenase family, which are involved in dihydrotestosterone biosynthesis, has moderate similarity to steroid 5 alpha-reductase A1 (human SRD5A1), which converts testosterone to dihydrotestosterone 3-oxo-5-alpha-steroid 4-dehydrogenase F42F12.4 F42F12.4 Member of the acireductone dioxygenase family, has moderate similarity to uncharacterized human SIPL F42F12.6 F42F12.6 Protein of unknown function, has very strong similarity to uncharacterized C. elegans F42F12.1 F42F12.7 F42F12.7 Protein of unknown function, has strong similarity to uncharacterized C. elegans F42F12.6 F42G10.1 F42G10.1 Member of the M13 peptidase family of zinc metalloproteases, has low similarity to uncharacterized C. elegans Y19D10B.6 F42G10.1 encodes a neprilysin; neprilysins are thermolysin-like zinc metallopeptidases, found on the outer surface of animal cells, that negatively regulate small signalling peptides (e.g., enkephalin, tachykinin, insulin, and natriuretic peptides) by cleaving them; F42G10.1 has no clear orthologs in other organisms. F42G10.2 F42G10.2 Protein with high similarity to mitogen-activated protein kinase kinase 4 (human MAP2K4), which is a putative tumor suppressor involved in the response to cellular stress that triggers apoptosis, contains a protein kinase domain serine/threonine kinase F42G2.1 F42G2.1 Protein of unknown function F42G2.2 F42G2.2 Protein containing two DUF38 domains of unknown function, has high similarity to uncharacterized C. elegans F16G10.15 F42G2.3 F42G2.3 Protein of unknown function, has moderate similarity to uncharacterized C. elegans T08E11.5 F42G2.4 F42G2.4 Member of an uncharacterized protein family This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins; this gene's encoded protein also contains an FTH/DUF38 motif, which may also mediate protein-protein interaction. F42G2.5 F42G2.5 Protein containing a major sperm protein (MSP) domain, which are involved in sperm motility, and a C3HC4 type (RING) zinc finger, has a region of high similarity to a region of vesicle (VAMP)-associated membrane protein-associated protein A (human VAPA) F42G2.6 F42G2.6 Protein containing a homeobox domain (homeodomain), which are found in transcription factors F42G4.2 F42G4.2 Protein of unknown function, has high similarity to uncharacterized C. elegans T08B2.11 F42G4.4 F42G4.3;F42G4.4 Protein containing six LIM domains, which may mediate protein-protein interactions, has low similarity to zyxin (human ZYX), which is a component of adhesion plaques and adherens junctions that affects actin assembly and cytoskeleton reorganization F42G4.5 F42G4.5 Protein of unknown function F42G4.6 F42G4.6 Putative ortholog of C. elegans F44F4.10 gene product F42G8.10 F42G8.10 Protein of unknown function F42G8.11 F42G8.11 Protein with low similarity to mitsugumin 29 (mouse Mg29), which is a component of the triad junction between the sarcoplasmic reticulum and transverse tubules in striated muscle that may be involved in excitation-contraction coupling synaptic vesicle channel protein; sph-1 encodes a member of the synaptophysin/synaptoporin family that contains a MARVEL domain, a membrane-associating domain found in lipid-associating proteins, and contains a transmembrane domain. F42G8.12 F42G8.12 Protein with high similarity to S. pombe Rip1p, which is a rieske iron-sulfur protein and a subunit of the ubiquinol cytochrome c reductase complex, contains one Rieske iron-sulfur protein 2Fe-2S and one ubiquinol cytochrome reductase transmembrane domain ubiquinol-cytochrome C reductase; isp-1 encodes a Rieske iron sulphur protein (ISP) which is a subunit of the mitochondrial complex III in the mitochondrial membrane; the subunits are highly conserved in all mitochondria and aerobic bacteria; mitochondrial complex III catalyses electron transport from ubiquinol to cytochrome c; isp-1 mutants show low oxygen consumption, a decreased sensitivity to reactive oxygen species and increased lifespan suggesting that mitochondrial electron transport is a key factor affecting life span; isp-1 affects the rates of physiological processes like reproduction and development and also affects behavior. F42G8.3 pmk-2;F42G8.3 Mitogen-activated protein kinase that may be involved in response to osmotic and other cellular stresses protein kinase; The pmk-2 gene encodes a homolog of p38, a type of mitogen-activated protein kinase (MAPK) that in mammals is generally activated by diverse cellular stresses and ligands. F42G8.4 pmk-3;F42G8.4 Mitogen-activated protein kinase likely involved in response to osmotic and other cellular stresses protein kinase; pmk-3 encodes a homolog of p38, a mitogen-activated protein kinase (MAPK), activated in vitro by MEK6, indicating that it does respond like p38 to physiological stress; PMK-3 is expressed in nuclei throughout the intestine; PMK-3 is activated by osmotic stresses when heterologously expressed in mammalian cells; null mutants do not exhibit observable growth defects or hypersensitivity to several tested known stresses. F42G8.5 F42G8.5 Protein of unknown function F42G8.6 F42G8.6 Protein with strong similarity to human MOCS3, a molybdopterin synthase sulfurylase molybdenum/thiazole biosynthesis cofactor F42G8.7 F42G8.7 Protein with strong similarity to C. elegans C06A6.5 gene product F42G8.8 F42G8.8 Member of the serine or threonine protein phosphatase family, has low similarity to mouse Ppp1cc, which is the catalytic subunit of protein phosphatase 1 and which functions in cellular signal transduction and is required for normal sperm fertility ser/thr-protein phosphatase F42G8.9 F42G8.9 Protein of unknown function F42G9.1 F42G9.1 Member of the protein phosphatase 2C family, which are Mg2+ dependent protein serine and threonine phosphatases, has moderate similarity to human PPM1G, which is a protein serine and threonine phosphatase as well as a pre-mRNA splicing factor Protein phosphatase F42G9.2 cyp-6;F42G9.2 Cyclophilin-related peptidylprolyl cis-trans-isomerase cyp-6 encodes a cyclophilin most similar to human secreted cyclophilin type B isoforms that is functional when expressed in E. coli; it is expressed in the intestine. F42G9.4 F42G9.4 Protein of unknown function F42G9.5 F42G9.5 Member of the aldehyde dehydrogenase protein family betaine-aldehyde dehydrogenase F42G9.6 F42G9.6 Protein with similarity at the C-terminus to human Hs.124275 protein, mRNA for KIAA0659 protein, isolated from brain cDNA library F42G9.7 F42G9.7 Protein containing two C2 domains, which may be involved in calcium-dependent phospholipid binding, has high similarity to a region of synaptotagmin (human SYT1), which is a synaptic vesicle protein that regulates neurotransmitter release Synaptotagmin F42G9.8 F42G9.8 Tyrosylprotein sulfotransferase-like protein that in humans is an integral membrane glycoprotein of the trans Golgi network F42G9.9 ptl-1;tau-1;F42G9.3;F42G9.9 Tau-repeat protein that promotes microtubule assembly ptl-1 encodes a microtubule-binding protein that is homologous to members of the tau/MAP2/MAP4 subfamily of microtubule-associated proteins (OMIM:157140, abnormal aggregates of hyperphosphorylated tau are associated with several neurodegenerative disorders, including Alzheimer's disease, Pick's disease, and corticobasal degeneration); by homology, PTL-1 is predicted to promote microtubule assembly and stability, and to play a role in maintaining neuronal integrity and axonal transport; in vitro, bacterially expressed PTL-1 can bind microtubules; ptl-1 mRNA is expressed at highest levels in the embryo and early larval stages, while PTL-1 is detected in embryonic hypodermis and head neurons and then in the mechanosensory neurons, ALML, ALMR, AVM, PLML, and PLMR, in larvae and adults; as loss of ptl-1 function via mutation or large-scale RNAi screens does not result in any obvious abnormalities, the precise role of PTL-1 in C. elegans development and/or behavior is not yet known. F42H10.2 F42H10.2 Protein of unknown function, has high similarity to uncharacterized C. elegans F11C1.1 F42H10.3 F42H10.3 Protein containing one Src homology 3 (SH3) domain, which bind proline-rich peptides, has a region of high similarity to a region of LIM and SH3 protein 1 (human LASP1), which binds actin and is amplified in breast carcinomas F42H10.4 F42H10.4 Member of the nebulin family of muscle proteins, which are thought to play a role in binding and stabilizing F-actin, contains LIM domains, has a region of high similarity to a region of LIM and SH3 protein 1 (human LASP1), which binds actin F42H10.5 F42H10.5 Protein of unknown function F42H10.6 F42H10.6 Protein containing one uncharacterized bacterial PaaI domain, has moderate similarity to uncharacterized human HT012 F42H10.7 F42H10.7 Protein of unknown function, has low similarity to uncharacterized human DGSI F42H11.1 F42H11.1 Protein containing a DUF236 domain of unknown function, has strong similarity to uncharacterized C. elegans C36F7.5 F42H11.2 lem-3;Ce-Lem3;F42H11.2 Protein containing a LEM domain, which are composed of two parallel alpha helices and are found in inner nuclear membrane proteins, and two ankyrin (Ank) repeats, which may mediate protein-protein interactions ankyrin domain F43A11.1 F43A11.1 Protein of unknown function, has high similarity to uncharacterized C. elegans H12C20.5 G-protein coupled receptor F43B10.1 F43B10.1 Protein of unknown function F43B10.2 F43B10.2 Protein of unknown function, has weak similarity to C. elegans C18B2.5 F43C1.1 F43C1.1 Member of the protein phosphatase 2C family, which are Mg2+ dependent protein serine and threonine phosphatases, contains 13 leucine rich repeats, has low similarity to a region of suprachiasmatic nucleus circadian oscillatory protein (rat Scop) leucine rich repeat F43C1.2 mpk-1;sur-1;F43C1.2 Serine/threonine protein kinase required for vulval induction, member of the MAP kinase subfamily serine/threonine kinase (CDC2/CDC28 subfamily); mpk-1 encodes a mitogen-activated protein (MAP) kinase that acts in the vulval precursor cells to affect LET-60(Ras)-mediated induction of vulval cell fates, and also affects larval viability, morphology of the male spicules, and acts in combination with mek-2 to permit germ cell exit from the pachytene stage of first meiotic prophase; both LIN-1 and LIN-31 act genetically downstream of mpk-1 with respect to vulval induction, and LIN-1 and LIN-31 are substrates for MPK-1 in vitro. F43C1.3 F43C1.3 Member of the ribosomal prokaryotic L21 protein family, which are part of the large ribosomal subunit F43C1.4 nhr-20;F43C1.4 Protein containing a nuclear hormone receptor C4-type zinc finger domain and a nuclear hormone receptor ligand-binding domain, has weak similarity to C. elegans NHR-80, which is involved in embryogenesis and morphogenesis Zinc finger, C4 type (two domains) F43C1.5 F43C1.5 Protein containing a CUE domain F43C11.1 F43C11.1 Protein of unknown function, putative paralog of C. elegans F43C11.2 F43C11.10 F43C11.10 Protein of unknown function F43C11.11 F43C11.11 Protein of unknown function, has moderate similarity to C. elegans F16G10.4 F43C11.12 F43C11.12 Protein of unknown function, has moderate similarity to C. elegans F16G10.6 F43C11.2 F43C11.2 Protein of unknown function, putative paralog of C. elegans F43C11.1 F43C11.3 F43C11.3 Protein of unknown function, has strong similarity to C. elegans ZK512.7 F43C11.4 F43C11.4 Protein of unknown function, has moderate similarity to C. elegans F16G10.11 F43C11.5 F43C11.5 Protein of unknown function, has strong similarity to C. elegans T14G12.6 F43C11.6 F43C11.6 Protein of unknown function F43C11.7 F43C11.7 Protein with strong similarity to C. elegans ZK1240.8 F43C11.8 F43C11.8 Putative paralog of C. elegans ZK1240.2 F43C11.9 F43C11.9 Protein of unknown function, has weak similarity to C. elegans T01C3.9 F43C9.1 F43C9.1 Protein containing an F-box domain, which serve as a link between a target protein and a ubiquitin-conjugating enzyme This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins. F43C9.2 F43C9.2 Member of an uncharacterized protein family EF-hand calcium binding protein F43C9.3 F43C9.3 Protein of unknown function, has a region of weak similarity to a region of myosin I from rat (rat Myr-1), which is a myosin ATPase that maintains cortical tension and may move actin filaments and the plasma membrane relative to each other F43C9.4 mig-13;F43C9.4 Protein which acts to position migrating neurons along an anteroposterior axis, has weak similarity to H. sapiens BMP1 gene product [bone morphogenetic protein 1 (GenBank)] LDL-receptor class repeats; C1R/C1S-like repeats; mig-13 encodes a novel single-pass transmembrane protein with a N-terminal signal sequence and two motifs that have been implicated in protein-protein interactions: a CUB domain and a LDL receptor repeat; mig-13 affects the migration and thus the positioning of the Q neuroblasts and their descendants and also the anterior migration of the BDU neuron and may be a component of a global anterior/posterior migration system; a mig-13-gfp translational fusion protein is expressed in embryonic pharyngeal, hypodermal and anterior body neuronal precursors as well as in the cell bodies and axons of a number of neurons in the retrovascular ganglion and the ventral cord; mig-13 localizes to the plasma membrane; mig-13 expression along the A/P axis is restricted by hox gene activity. F43D2.1 F43D2.1 Protein containing a cyclin N-terminal domain, has low similarity to cyclin C (human CCNC), which functions in transcription, cell-cell adhesion, and cell proliferation and may be associated with lymphoid malignancies G1/S-specfic cyclin C like F43D2.2 F43D2.2 Putative ortholog of C. elegans M199.2 gene product F43D2.3 F43D2.3 Protein with strong similarity to C. elegans Y37E11B.10 gene product F43D2.4 hot-1;F43D2.4 Protein of unknown function, has low similarity to odorant response abnormal C. elegans ODR-2, which is involved in chemosensation of volatile odorants hot-1 encodes a predicted paralog of ODR-2 and contains a Ly-6 domain; may be expressed in neurons. F43D9.1 F43D9.1 Weakly similar to D. melanogaster coracle;predicted to be membrane spanning Band 4.1 domain F43D9.2 F43D9.2 Member of the Ras superfamily of GTP binding proteins, has a region of moderate similarity to S. cerevisiae Ypt1p, which is a GTP-binding protein required for vesicle transport from ER to Golgi and within the Golgi stack F43D9.3 F43D9.3 Protein with high similarity to vesicle transport-related protein (rat RA410), which interacts with and positively regulates syntaxin 5 (rat Stx5a) as part of a complex, member of the Sec 1 family, which may be involved in secretion Sec1 family F43D9.4 sip-1;F43D9.4 Member of the Hsp20 or alpha crystallin family, has moderate similarity to C. elegans HSP-16, which is involved in the heat shock response Heat shock hsp20 proteins F43D9.5 taf7.3;F43D9.5 Protein of unknown function, has weak similarity to C. elegans F48D6.1 The taf-11.3 gene encodes an ortholog of human TATA-binding protein associated factor TAF11 (TAFII28, OMIM:600772) that is a component of the TFIID general transcription factor that recognizes the transcription start site; TAF-11.3 is required for proper post-embryonic development. F43E2.1 F43E2.1 Protein with strong similarity at the C-terminus to human HSRBP4 protein, an RNA polymerase II subunit hsRBP4 F43E2.10 F43E2.10 Putative ortholog of C. elegans F43E2.6 gene product F43E2.11 F43E2.11 Protein with moderate similarity to C. elegans T02G5.10 gene product F43E2.2 F43E2.2 Protein of unknown function, has a region of high similarity to DNA directed RNA polymerase II polypeptide D (human POLR2D), which interacts with the RPB7 subunit (POLR2G) F43E2.3 F43E2.3 Protein of unknown function F43E2.4 F43E2.4 Member of the ABC transporter family, which are involved in membrane translocation of a variety of compounds, contains an ABC transporter transmembrane domain, has moderate similarity to transporter associated with antigen processing 2 (human TAP2) membrane transport protein; haf-2 encodes a predicted transmembrane protein of the ATP-binding cassette (ABC) transporter superfamily; by homology, HAF-2 is proposed to function in ATP-dependent transport of molecules across plasma and intracellular membranes; however, as loss of HAF-2 function via RNA-mediated interference (RNAi) does not result in any abnormalities, the precise role of HAF-2 in C. elegans development and/or behavior is not yet known. F43E2.5 F43E2.5 Member of the peptide methionine sulfoxide reductase family, which repair damaged proteins, has a region of moderate similarity to a region of methionine sulfoxide reductase A (human MSRA), which reduces methionine sulfoxide residues of damaged proteins F43E2.6 F43E2.6 Putative ortholog of C. elegans F43E2.10 gene product F43E2.7 F43E2.7 Protein of unknown function, has low similarity to uncharacterized human MTCH1 F43E2.8 hsp-4;F43E2.8 Protein with high similarity to heat shock 70kD protein 5 (rat Hspa5), which is a stress-induced putative chaperone involved in protein folding in the endoplasmic reticulum, member of the Hsp70 family, which are stress-induced protein chaperones heat shock protein; hsp-4 encodes a predicted homolog of the mammalian ER chaperone BiP that affects embryonic and larval viability; expression is most prominent in the spermatheca and transcription of hsp-4 is induced in the gut and in the hypodermis upon ER stress. F43E2.9 F43E2.9 Protein of unknown function F43G6.1 F43G6.1 Protein of unknown function, has low similarity to a region of S. pombe Dna2p, which is a DNA helicase involved in DNA replication and DNA repair DNA binding protein; dna-2 encodes the C. elegans ortholog of the yeast and vertebrate Dna2 replication helicases; by homology, DNA-2 is predicted to function as an endonuclease and an ATP-dependent helicase that is involved in DNA replication and repair; in C. elegans, DNA-2 activity is required maternally and zygotically to maintain normal rates of cell division and for proper germ-line, embryonic, and larval development; DNA-2 activity is temperature-sensitive: animals lacking DNA-2 at 16 degrees Celsius (C) are less severely affected than those at 20 or 25 degrees C; in the hermaphrodite gonad, DNA-2 localizes to nuclei of germ cells and developing oocytes, and expression continues in embryos up to the comma stage; DNA-2 then reappears at the L3 larval stage, and in L3 and L4 larvae is visible in the proliferating somatic cells of the uterus and spermatheca. F43G6.10 F43G6.10 Protein of unknown function F43G6.2 F43G6.2 Protein of unknown function F43G6.3 F43G6.3 Protein with strong similarity to C. elegans T19H12.2 gene product Leucine Rich Repeat (2 copies) F43G6.4 F43G6.4 Member of the histone deacetylase family, which catalyze removal of acetyl groups from histones, has low similarity to a region of MEF2-interacting transcription repressor (histone deacetylase 7B, HDAC-related protein, human HDAC9) transcriptional regulatory protein (RPD3) F43G6.5 F43G6.5 Protein with high similarity to poly A polymerase beta (mouse Papolb), which is a testis specific poly(A) polymerase that catalyzes the addition of polyadenosine to the 3' end of messenger RNAs poly (A) polymerase F43G6.6 F43G6.6 Protein containing a Jumonji (jmjC) domain F43G6.7 F43G6.7 Protein of unknown function F43G6.8 F43G6.8 Protein with a putative RING-type zinc finger domain, has moderate similarity to C. elegans Y6D1A.B Zinc finger, C3HC4 type (RING finger) F43G6.9 F43G6.9 Protein of unknown function F43G9.1 F43G9.1 Putative NAD+-isocitrate dehydrogenase isocitrate dehydrogenase; This gene encodes a protein predicted by Eisenberg and coworkers, with 52% accuracy, to be mitochondrial. F43G9.10 F43G9.10 Protein of unknown function, has moderate similarity to uncharacterized microfibrillar associated protein 1 (human MFAP1), which may be a component of the elastin-associated microfibrils of the extracellular matrix MICROFIBRILLAR-ASSOCIATED PROTEIN 1 (ASSOCIATED MICROFIBRIL PROTEIN) (AMF) F43G9.11 ces-1;F43G9.11 Member of the Snail family of transcription factors required for normal programmed cell death of NSM and I2 sister neurons Zinc finger, C2H2 type (5 domains); ces-1 encodes a C2H2-type zinc finger transcription factor that is a member of the Snail family of proteins that includes Drosophila Scratch, Snail, and Slug, and human SNAIL and SLUG; although the normal function of CES-1 is not fully understood, gain-of-function mutations indicate that CES-1 can function as a transcriptional repressor that blocks programmed cell death in specific neurons by inhibiting expression of the cell-death activator EGL-1; in regulating EGL-1 expression, CES-1 appears to antagonize the transcriptional activity of the bHLH proteins, HLH-2 and HLH-3; despite its cell-type specific role in apoptosis, CES-1 expression is reportedly detected in many embryonic nuclei from the 100-cell stage of embryogenesis through the beginning of morphogenesis, with some CES-1 expression remaining at later embryonic stages; genetic studies indicate that CES-1 is negatively regulated by the bZIP transcription factor CES-2, which can bind CES-1 upstream sequences in vitro and thus may directly regulate CES-1 transcription in vivo. F43G9.12 F43G9.12 Protein with low similarity to chromosome 2 open reading frame 3 (GC factor, human C2ORF3), which is a transcriptional repressor that binds to GC-rich sequences Human GC-rich sequence DNA-binding factor (GCF) like F43G9.13 F43G9.13 Protein of unknown function F43G9.2 F43G9.2 Protein containing a LysM domain, which may bind peptidoglycans F43G9.3 F43G9.3 Member of the mitochondrial carrier protein family of membrane transporters, has low similarity to S. cerevisiae Leu5p, which is a mitochondrial carrier membrane transporter mitochondrial carrier protein F43G9.4 F43G9.4 Protein of unknown function F43G9.5 F43G9.5 Protein with high similarity to cleavage and polyadenylation specific factor 5 (human CPSF5), which is a 25 kDa subunit of the cleavage factor Im (CF Im) that is likely to play a role in pre-mRNA 3' end processing, contains a mutT domain F43G9.5 encodes a NUDIX hydrolase that is a (perhaps evolutionarily conserved) target of transcriptional activation by DAF-16; loss of F43G9.5 function has no obvious effect on lifespan, dauer formation, or fat storage. F43G9.6 fer-1;F43G9.6 Protein expressed in the testis that is required for functional sperm C2 domain (2 domains); fer-1 encodes a C2-domain containing protein required during spermatogenesis for fusion of membranous vesicles with the spermatid plasma membrane, a process which promotes maturation of spermatids to motile spermatozoa; FER-1 is orthologous to the membrane-anchored cytosolic human protein dysferlin (FLJ00175 or DYSF; OMIM:603009), which when mutated leads to Miyoshi myopathy (OMIM:254130); FER-1 is also homologous to myoferlin (MYOF, OMIM:604603) and otoferlin (OTOF, OMIM:603681), which when mutated leads to autosomal recessive deafness 9 (OMIM:601071); FER-1 mRNA is detected in primary spermatocytes. F43G9.7 F43G9.7 Member of the reverse transcriptase family, which are RNA-dependent DNA polymerases, as a region of weak similarity to a region of LINE retrotransposable element 1 (human LRE1), which reverse transcribes L1 elements and has endonuclease activity reverse transcriptase F43G9.8 F43G9.8 Protein of unknown function F43G9.9 cpn-1;F43G9.9 Protein containing a calponin family repeat and a calponin homology domain, which bind actin, has low similarity to a region of calponin 1 (rat Cnn1), which is a putative actin-binding protein involved in smooth muscle cell differentiation smooth muscle protein SM22 like; cpn-1 encodes a calponin homolog, more closely related to calponin per se than to its paralogs transgelin (SM22 alpha) or neuronal protein NP25, that is is dispensable for viability and gross morphology in mass RNAi screens, and that has no obvious mutant phenotype in a rearrangement that probably disrupts cpn-1. F43H9.1 F43H9.1 Member of the enoyl-CoA hydratase or isomerase family, has low similarity to short chain enoyl-Coenzyme A hydratase 1 (rat Echs1), which catalyzes the hydration of trans-2-enoyl-CoA forming 3-hydroxyacyl-CoA in mitochondrial fatty acid beta-oxidation enoyl-coA hydratase F43H9.2 F43H9.2 Protein with high similarity to serine palmitoyltransferase long chain base subunit 2 (human SPTLC2), which catalyzes the first step in the formation of ceramide, contains two aminotransferase class I and II domains serine palmtoyltransferase; This gene encodes a protein predicted by Eisenberg and coworkers, with 68% accuracy, to be mitochondrial. F43H9.3 F43H9.3 Protein with moderate similarity to C. elegans F31C3.2 gene product F43H9.4 F43H9.4 Protein of unknown function F44A2.1 F44A2.1 Protein of unknown function, has a region of low similarity to a region of carbon catabolite repressor negative regulator of transcription complex subunit 2 (human CNOT2), which is a component of the CCR4-NOT global transcriptional regulator complex F44A2.2 nShab2;F44A2.2 Putative voltage-gated potassium channel potassium channel protein F44A2.3 F44A2.3 Protein containing a lipopolysaccharide-binding protein, bactericidal permeability-increasing protein, or cholesteryl ester transfer protein C-terminal domain, has weak similarity to uncharacterized C. elegans F10D11.6 F44A2.4 F44A2.4 Member of the nuclear hormone receptor/Zinc finger protein family C4-type zinc finger F44A2.5 F44A2.5 Protein containing two MIF4G (middle domain of eukaryotic initiation factor 4G) domains F44A2.7 F44A2.7 Protein of unknown function, has low similarity to uncharacterized C. elegans T24A6.20 F44A6.1 F44A6.1 Protein with moderate similarity to nucleobindin 2 (mouse Nucb2), which is a calcium binding protein that may play a role in calcium ion homeostasis nucleobindin; F44A6.1 encodes two isoforms of a nucleobindin homolog that each contain a calcium-binding EF-hand domain and a glutamine/asparagine-rich domain; F44A6.1 is expressed in muscle (pharyngeal, body wall, and vulval), with weak expression in head and tail neurons and in (mainly posterior) intestinal cells; F44A6.1 has no obvious function in vivo, since it has no obvious phenotype when deleted or inactivated by RNAi (whether in a normal genetic background, or in goa-1 and egl-30 mutant backgrounds). F44A6.2 sex-1;cnr14;nhr-24;F44A6.2 Nuclear hormone receptor of the retinoic acid receptor (RAR) subfamily; required for hermaphrodite sex-determination nuclear hormone receptor F44A6.3 F44A6.3 Protein of unknown function F44A6.4 F44A6.4 Protein of unknown function F44A6.5 F44A6.5 Protein of unknown function F44B9.1 F44B9.1 Protein of unknown function, has a region of low similarity to a region of N-acylaminoacyl-peptide hydrolase (rat Apeh), which catalyzes the hydrolysis of an amino-terminally acetylated peptide to release an N-acetylamino acid acylamino-acid-releasing enzyme F44B9.2 F44B9.2 Protein of unknown function F44B9.3 F44B9.3 Protein containing a cyclin N-terminal domain, has low similarity to a region of cyclin T1 (mouse Ccnt1), which is a putative regulatory subunit of the positive transcription elongation factor b and functions in transcription elongation F44B9.4 F44B9.4 Protein containing a cyclin N-terminal domain, has a region of low similarity to a region of cyclin T1 (human CCNT1), which is a regulatory subunit of the positive transcription elongation factor b and functions in transcription elongation F44B9.5 F44B9.5 Protein containing a CUE domain, has moderate similarity to uncharacterized ancient ubiquitous protein 1 (mouse Aup1) F44B9.6 lin-36;F44B9.6 Part of the class B pathway that antagonizes vulval induction F44B9.7 F44B9.7 Protein of unknown function The protein product of this gene is predicted to contain a glutamine/asparagine (Q/N)-rich ('prion') domain, by the algorithm of Michelitsch and Weissman (as of the WS77 release of WormBase, i.e., in wormpep77). F44B9.8 F44B9.8 Protein with high similarity to S. pombe Rfc3p, which is the third subunit of replication factor C, member of the ATPase family associated with various cellular activities ARPA F44B9.9 F44B9.9 Member of the Ser/Thr protein phosphatase protein family Protein phosphatase F44C4.2 F44C4.2 Member of the nuclear hormone receptor/Zinc finger protein family zinc finger-containing protein F44C4.3 cpr-4;F44C4.3 Member of the cysteine protease protein family cathepsin B-like cysteine proteinase 4 precursor; cpr-4 encodes a cathepsin B-like cysteine protease expressed at all life stages. F44C4.4 F44C4.4 Protein of unknown function, has a region of weak similarity to a region of C. elegans LIN-15B, which is a negative regulator of the LET-23 receptor-tyrosine kinase and LET-60 ras signaling pathway F44C4.5 F44C4.5 Protein with high similarity to palmitoyl-protein thioesterase (rat Ppt), which is an enzyme which may be involved in neurogenesis and fatty acid:protein modification, member of the palmitoyl protein thioesterase family palmitoyl-protein thioesterase precursor; ppt-1 is orthologous to the human gene PALMITOYL-PROTEIN THIOESTERASE 1 (PPT1; OMIM:600722), which when mutated leads to infantile neuronal ceroid lipofuscinosis 1 (OMIM:256730) and juvenile neuronal ceroid lipofuscinosis with granular osmiophilic deposits (OMIM:600680). F44C8.1 F44C8.1 Member of the cytochrome P450 family, has low similarity to cytochrome P450 subfamily 2C polypeptide 39 (mouse Cyp2c39), which is a liver enzyme that metabolizes arachidonic acid to 14,15-cis-epoxyeicosatrienoic acid cytochrome P450 F44C8.10 nhr-18;F44C8.10 Member of the nuclear hormone receptor/Zinc finger protein family nuclear hormone receptor; nhr-126 encodes a member of the nuclear hormone receptor family. F44C8.11 nhr-96;F44C8.11 Member of the nuclear hormone receptor/Zinc finger protein family nuclear hormone receptor F44C8.2 F44C8.2 Protein containing a nuclear hormone receptor C4-type zinc finger domain and a nuclear hormone receptor ligand-binding domain, has moderate similarity to C. elegans NHR-58, which is involved in embryogenesis and morphogenesis nuclear hormone receptor F44C8.3 F44C8.3;nhr-18 Protein containing nuclear hormone receptor C4-type zinc finger and ligand-binding domains, has low similarity to C. elegans NHR-58, which is a putative ligand-dependent nuclear receptor that plays a role in embryogenesis and morphogenesis nuclear hormone receptor; The nhr-18 gene encodes a homolog of human CYP21, which when mutated leads to congenital adrenal hyperplasia (OMIM:201910). F44C8.4 F44C8.4 Protein containing nuclear hormone receptor C4-type zinc finger and ligand-binding domains, has moderate similarity to C. elegans NHR-58, which is a putative ligand-dependent nuclear receptor that plays a role in embryogenesis and morphogenesis nulcear hormone receptor F44C8.5 F44C8.5 Protein containing nuclear hormone receptor C4-type zinc finger and ligand-binding domains, has moderate similarity to C. elegans NHR-58, which is a putative ligand-dependent nuclear receptor that plays a role in embryogenesis and morphogenesis zinc finger protein F44C8.6 nhr-56;F44C8.6 Member of the nuclear hormone receptor/Zinc finger protein family zinc finger protein F44C8.7 F44C8.7 Protein with moderate similarity to solute carrier family 35 member 3 (UDP-N-acetylglucosamine(UDP-GlcNAc) transporter, human SLC35A3), which transports nucleotide sugars F44C8.8 F44C8.8 Protein containing two nuclear hormone receptor C4-type zinc finger domains and one nuclear hormone receptor ligand-binding domain, has moderate similarity to C. elegans NHR-58, which is a putative ligand-dependent nuclear receptor zinc finger protein F44C8.9 F44C8.9 Member of the nuclear hormone receptor/Zinc finger protein family zinc finger protein F44D12.1 F44D12.1 Protein with putative PDZ domain, had moderate similarity to tight junction proteins, including H. sapiens DLG5, TJP1 and ZO-2 gene products and Drosophila tam gene product Tight junction protein like F44D12.10 F44D12.10 Protein with moderate similarity to C. elegans C32E8.1 gene product Zinc finger, C3HC4 type (RING finger) F44D12.11 F44D12.11 Protein containing a protein kinase domain, has low similarity to S. cerevisiae Rim11p, which is a protein tyrosine kinase that plays roles in sporulation and meiosis F44D12.2 F44D12.2 Protein of unknown function, has weak similarity to C. elegans C15C8.5; may be anchored to the membrane of a secretory vesicle or the Golgi apparatus F44D12.3 F44D12.3 Protein containing a major sperm protein (MSP) domain, which are involved in sperm motility, has very strong similarity to uncharacterized C. elegans F44D12.5 F44D12.4 F44D12.4 Putative paralog of C. elegans C35D10.2, has strong similarity to human GLUT1 C-terminal binding protein (Hs.6454) F44D12.5 F44D12.5 Protein containing a major sperm protein domain, which are involved in sperm motility, has very strong similarity to uncharacterized C. elegans F44D12.7 F44D12.6 F44D12.6 Protein of unknown function F44D12.7 F44D12.7 Protein containing a major sperm protein (MSP) domain, which are involved in sperm motility, has very strong similarity to uncharacterized C. elegans F44D12.3 F44D12.8 F44D12.8 Protein of unknown function, has high similarity to uncharacterized C. elegans T08B2.11 F44D12.9 F44D12.9 Protein with moderate similarity to C. elegans F16H11.3 gene product F44E2.10 F44E2.10 Protein of unknown function F44E2.2 F44E2.2 Member of the reverse trancriptase family, which are RNA-dependent DNA polymerases, contains two retroviral integrase core domains, which are the catalytic domains that can act as endonucleases, and two zinc knuckle domains, which can bind RNA or DNA Reverse Transcriptase F44E2.3 F44E2.3 Coiled-coil protein, has weak similarity to S. cerevisiae Sec3p, has weak similarity to myosins DnaJ F44E2.4 F44E2.4 Protein containing a low-density lipoprotein (LDL) receptor class A domain F44E2.5 F44E2.5 Protein of unknown function F44E2.6 F44E2.6 Protein containing a DUF25 domain of unknown function, has high similarity to uncharacterized C. albicans Orf6.1782p Transcription regulation F44E2.7 F44E2.7 Protein containing four C2H2 type zinc finger domains, which bind nucleic acids F44E2.8 F44E2.8 Protein with moderate similarity to C. elegans F40F8.5 gene product F44E2.9 F44E2.9 Putative ortholog of C. elegans 3I940 gene product F44E5.1 F44E5.1 Protein of unknown function F44E5.2 F44E5.2 Protein containing two leucine rich repeats, which mediate protein-protein interactions, has a region of low similarity to a region of C. elegans ZYG-11, which is required for zygote formation Leucine Rich Repeat (2 copies) F44E5.3 F44E5.3 Protein with strong similarity to C. elegans F47D12.5 gene product F44E5.4 F44E5.4 Protein with high similarity to heat shock 70kD protein 8 (human HSPA8), which is a transcription co-factor, member of the Hsp70 family, which are stress-induced protein chaperones Heat shock hsp70 proteins F44E5.5 F44E5.5 Protein with high similarity to heat shock 70kD protein 8 (human HSPA8), which is a transcription co-factor, member of the Hsp70 family, which are stress-induced protein chaperones Heat shock hsp70 proteins F44E7.2 F44E7.2 Member of the haloacid dehalogenase or epoxide hydrolase family, has low similarity to S. pombe Pho2p, which is a specific p-nitrophenylphosphatase nitrophenylphosphatase F44E7.3 F44E7.3 Protein of unknown function, has weak similarity to C. elegans ZK1055.1 F44E7.4 F44E7.4 Member of the insulinase (peptidase M16) family, which are divalent cation-dependent, has moderate similarity to insulin-degrading enzyme (receptor accessory factor, insulinase, human IDE), which degrades insulin, TGF alpha (TGFA) and amyloid beta (APP) peptidase; This gene encodes a protein predicted by Eisenberg and coworkers, with 68% accuracy, to be mitochondrial. F44E7.5 F44E7.5 Protein of unknown function F44E7.6 F44E7.6 Protein containing an F-box domain, which serve as a link between a target protein and a ubiquitin-conjugating enzyme, and a DUF38 domain of unknown function, has high similarity to uncharacterized C. elegans T05H4.2 This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins; this gene's encoded protein also contains an FTH/DUF38 motif, which may also mediate protein-protein interaction. F44E7.7 F44E7.7 Member of the sugar (and other) transporter family, has low similarity to solute carrier family 17 member 1 (mouse Slc17a1), which is involved in sodium-dependent phosphate transport and mediates hepatic and renal anion drug transport F44E7.8 F44E7.8 Nuclear hormone receptor nuclear hormone receptor F44E7.9 F44E7.9 Protein of unknown function F44E8.1 F44E8.1 Member of the reverse transcriptase family, which are RNA-dependent DNA polymerases, has a region of low similarity to a region of LINE retrotransposable element 1 (human LRE1), which reverse transcribes L1 elements and has endonuclease activity F44F1.1 F44F1.1 Member of the calpain family of cysteine proteases, has a region of low similarity to a region of calpain 2 (rat Capn2), which is the large subunit of the cysteine-type protease m-calpain that regulates apoptosis and signal transduction calpain-like protease F44F1.2 F44F1.2 Protein with moderate similarity to C. elegans F31A9.1 gene product F44F1.3 F44F1.3 Member of the calpain family of cysteine proteases, has a region of low similarity to a region of calpain 2 (rat Capn2), which is the large subunit of the cysteine-type protease m-calpain that regulates apoptosis and signal transduction calpain-like protease F44F1.4 F44F1.4 Protein of unknown function, has high similarity to uncharacterized C. elegans F44F1.6 F44F1.5 F44F1.5 Protein of unknown function, has high similarity to uncharacterized C. elegans F44F1.4 F44F1.6 F44F1.6 Member of an uncharacterized protein family F44F1.7 F44F1.7 Protein of unknown function, has low similarity to uncharacterized C. elegans ZK1053.4 vet-6 encodes a protein that contains a spectrin repeat; vet-6 is preferentially transcribed in embryos prior to gastrulation. F44F4.1 F44F4.1 Protein of unknown function that may be anchored to the membrane of a secretory vesicle or the Golgi apparatus F44F4.10 F44F4.10 Protein of unknown function, has strong similarity to uncharacterized C. elegans F42G4.6 F44F4.11 F44F4.11 Protein with strong similarity to alpha tubulin (C. elegans TBA-1), member of the tubulin-FtzA family, which are involved in polymer formation tubulin alpha-2 chain; tba-4 encodes a member of the alpha tubulin family that also includes tba-1, tba-2, and tba-3, and affects embryonic viability. F44F4.13 sra-11;F44F4.13 G protein-coupled receptor; member of a subfamily with SRA proteins, which are expressed in chemosensory neurons; no homolog found in human or D. melanogaster 7TM chemoreceptor, sra family F44F4.2 F44F4.2 Member of the protein-tyrosine phosphatase family, which are involved in control of cell growth, proliferation, and differentiation, has a region of weak similarity to a region of human PTPN9, which is a non-receptor type protein tyrosine phosphatase Protein-tyrosine phosphatase F44F4.3 F44F4.3 Protein of unknown function F44F4.4 ptr-8;F44F4.4 Member of an uncharacterized protein family ptr-8 encodes a member of the Patched superfamily. F44F4.5 sra-10;F44F4.5 G protein-coupled receptor, expressed in sensory neurons, other neurons, and muscle, no homolog found in human or D. melanogaster 7TM chemoreceptor, sra family F44F4.6 gly-1;F44F4.6 Member of the core-2 or I-branching enzyme family, which form blood group I-antigens or side-chains of O-glycans, has low similarity to core 2 beta-1,6-N-acetylglucosaminyltransferase-leukocyte type (human GCNT1), which forms O-glycan branched structures beta-1,6-N-acetylglucosaminyltransferase; gly-1 encodes a transmembrane glycosyltransferase similar to 2/I N-acetylglucosaminyltransferase; in vitro, GLY-1 demonstrates UDP-Glc:GalB1-3GalNac-R glucosyltransferase activity; gly-1 expression is detected in adult hypodermal seam cells and possibly some neurons adjacent to the anterior bulb of the pharynx; neither gly-1 loss-of-function mutations nor RNA mediated interference (RNAi) result in any obvious abnormalities, suggesting that gly-1 function is not essential for C. elegans development and/or behavior. F44F4.7 sra-12;F44F4.7 G protein-coupled receptor; member of a subfamily with SRA proteins, which are expressed in chemosensory neurons; no homolog found in human or D. melanogaster 7TM chemoreceptor, sra family F44F4.8 F44F4.8 Member of the transposase family, which are required for excising and inserting mobile genetic elements, has very strong similarity to uncharacterized C. elegans Y95B8A.3 transposase F44F4.9 F44F4.9 Protein of unknown function F44G3.1 F44G3.1 Member of the 7-transmembrane chemoreceptor family of G protein-coupled receptors (GPCR), has low similarity to C. elegans ODR-10, which is involved in odorant response 7TM receptor F44G3.10 F44G3.10 Protein of unknown function, has high similarity to uncharacterized C. elegans F10A3.1 F44G3.10 encodes a claudin homolog that may be required for normal cohesion of apical junctions in epithelia; F44G3.10 is worm-specific, with obvious homologs only in C. elegans; F44G3.10 has no obvious function in mass RNAi assays; claudins are integral membrane proteins with four transmembrane sequences that are found in mammalian tight junctions (TJs), induce TJs when transgenically expressed in cells normally lacking them, and can mediate the specific conductance of of specific ions (e.g., magnesium or calcium) through TJs while blocking the flow of water. F44G3.11 F44G3.11 Member of the 7-transmembrane chemoreceptor family of G protein-coupled receptors (GPCR), has low similarity to C. elegans ODR-10, which is involved in odorant response 7TM receptor F44G3.2 F44G3.2 Protein containing a plant ATP-guanido phosphotransferase N-terminal domain and an ATP:guanido phosphotransferase C-terminal catalytic domain, has moderate similarity to brain creatine kinase (rat Ckb), which is important for ATP regeneration arginine kinase F44G3.3 F44G3.3 Member of the reverse transcriptase family, which are RNA-dependent DNA polymerases, has a region of weak similarity to a region of LINE retrotransposable element 1 (human LRE1), which reverse transcribes L1 elements and has endonuclease activity F44G3.5 F44G3.5 Protein of unknown function, has high similarity to uncharacterized C. elegans T26E4.6 F44G3.6 skr-3;F44G3.6 Member of the Skp1 family, which are required for targeted protein degradation during the cell cycle, has moderate similarity to S. cerevisiae Skp1p, which is a component of the Cbf3 kinetochore and SCF (Skp1p-cullin-F-box) complexes The skr-3 gene encodes a homolog of Skp1 in S. cerevisiae that has no known function in vivo, since skr-3(RNAi) animals are at least superficially normal. F44G3.7 F44G3.7 Putative ortholog of C. elegans F15D3.4 gene product F44G3.8 F44G3.8 Protein containing five DUF38 domains of unknown function and three F-box domains, which link a target protein with a ubiquitin-conjugating enzyme, has a region of low similarity to C. elegans FOG-2, which is required for germ cells sexual identity F-box domain.; This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins; this gene's encoded protein also contains an FTH/DUF38 motif, which may also mediate protein-protein interaction. F44G3.9 F44G3.9 Protein containing a nuclear hormone receptor C4-type zinc finger domain, which may be involved in transcription regulation, has low similarity to nuclear receptor subfamily 2 group E member 3 (mouse Nr2e3), which is a transcriptional repressor Zinc finger, C4 type (two domains); nhr-111 encodes a member of the nuclear receptor superfamily; by homology, NHR-111 is predicted to function as a ligand-dependent transcriptional regulator, but as loss of nhr-111 activity via large-scale RNAi screens does not result in any abnormalities, the precise role of NHR-111 in C. elegans development and/or behavior is not yet known; an nhr-111 reporter construct is expressed in embryos and early larvae in a pair of neurons in the ventral ganglion of the head and in two cells that may be the somatic gonad precursors. F44G4.1 F44G4.1 Protein containing an IMP4 domain of unknown function, has low similarity to S. cerevisiae Imp4p, which is a component of U3 snoRNP that is required for pre-18S rRNA processing F44G4.2 F44G4.2;2J289 Protein with weak similarity to H. sapiens NDUFB2 (NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 2 (8kD, AGGG)) F44G4.3 F44G4.3 Protein of unknown function F44G4.4 F44G4.4 Protein containing two RNA recognition motifs (RRM, RBD, or RNP), has moderate similarity to a region of TAR DNA binding protein (human TARDBP), which binds the pyrimidine-rich HIV-1 TAR DNA sequence and inhibits HIV-1 transcription RNA binding protein F44G4.5 F44G4.5 Protein of unknown function, has high similarity to uncharacterized C. elegans C01G12.3 F44G4.6 F44G4.6 Protein of unknown function F44G4.7 F44G4.7 Protein of unknown function F44G4.8 F44G4.8 Member of the protein-tyrosine phosphatase family, which are involved in cell growth, contains two fibronectin type III domains, which are involved in cell surface binding, has weak similarity to protein tyrosine phosphatase receptor type J (human PTPRJ) protein tyrosine phosphatase F45B8.1 rgs-11;F45B8.1 Protein containing two regulator of G protein signaling domains, has a region of moderate similarity to regulator of G protein signaling 8 (rat Rgs8), which acts as a GTPase activating protein and accelerates modulation of G protein-coupled K+ channels phosphoprotein RGP4 like F45B8.2 rgs-10;F45B8.2 Protein containing one regulator of G protein signaling domain, has a region of low similarity to a region of regulator of G protein signaling 3 (human RGS3), which stimulates the GTPase activity of G protein alpha subunits phosphoprotein RGP4 like F45B8.3 F45B8.3 Protein of unknown function, has weak similarity to C. elegans grd-6 F45B8.4 pag-3;F45B8.4 Putative zinc-finger transcription factor required for the proper expression of mec-4 and mec-7 Zinc finger, C2H2 type (5 domains); The pag-3 gene encodes a homolog of the human gene ZNF195 (or p57KIP2), which when mutated leads to Beckwith-Wiedemann syndrome (OMIM:130650). F45C12.1 F45C12.1 Protein containing a DUF41 domain of unknown function, has moderate similarity to uncharacterized C. elegans ZK355.4 F45C12.10 F45C12.10 Protein containing a meprin and TRAF homology (MATH) domain, has moderate similarity to uncharacterized C. elegans C08E3.3 F45C12.11 F45C12.11 Protein containing a BTB or POZ domain, which are found in some DNA and actin binding proteins and may mediate protein-protein interactions, and a meprin and TRAF homology (MATH) domain, has moderate similarity to uncharacterized C. elegans C08E3.3 F45C12.12 F45C12.12 Protein containing a BTB (BR-C, ttk and babor) or POZ (Pox virus and zinc finger) domain, which are found in some DNA and actin binding proteins and may mediate protein-protein interactions, has moderate similarity to uncharacterized C. elegans F57C2.2 F45C12.13 F45C12.13 Protein of unknown function, has low similarity to uncharacterized C. elegans K05F6.9 F45C12.14 F45C12.14 Protein containing an F-box domain, which serve as a link between a target protein and a ubiquitin-conjugating enzyme, has low similarity to uncharacterized C. elegans M117.5 This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins; its encoded protein also contains a Pfam-B45 motif of presently unknown function. F45C12.15 F45C12.15 Protein containing two homeobox domains (homeodomains), which are found in transcription factors F45C12.16 F45C12.16 Protein containing a DUF41 domain of unknown function, has high similarity to uncharacterized C. elegans F58E1.4 F45C12.2 F45C12.2 Protein of unknown function F45C12.3 F45C12.3 Protein of unknown function, has weak similarity to uncharacterized C. albicans Orf6.2961p F45C12.4 F45C12.4 Protein containing a BTB (BR-C, ttk and babor) or POZ (Pox virus and zinc finger) domain, which are found in some DNA and actin binding proteins and may mediate protein-protein interactions, has moderate similarity to uncharacterized C. elegans F57C2.1 F45C12.5 F45C12.5 Protein containing an F-box domain, which serve as a link between a target protein and a ubiquitin-conjugating enzyme, has low similarity to uncharacterized C. elegans F36H5.5 This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins; its encoded protein also contains a Pfam-B45 motif of presently unknown function. F45C12.6 F45C12.6 Protein containing a BTB (BR-C, ttk and babor) or POZ (Pox virus and zinc finger) domain, which are found in some DNA and actin binding proteins and may mediate protein-protein interactions, has moderate similarity to uncharacterized C. elegans K02E7.9 F45C12.7 F45C12.7 Protein containing a BTB (BR-C, ttk and babor) or POZ (Pox virus and zinc finger) domain, which are found in some DNA and actin binding proteins and may mediate protein-protein interactions, has high similarity to uncharacterized C. elegans K02E7.9 F45C12.8 F45C12.8 Protein containing two DUF38 domains of unknown function and an F-box domain, which serves as a link between a target protein and a ubiquitin-conjugating enzyme, has weak similarity to C. elegans T07D3.1 This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins; this gene's encoded protein also contains an FTH/DUF38 motif, which may also mediate protein-protein interaction. F45C12.9 F45C12.9 Protein containing a DUF130 domain of unknown function F45D11.1 F45D11.1 Protein of unknown function, putative paralog of C. elegans F45D11.14 F45D11.10 F45D11.10 Protein of unknown function, putative paralog of C. elegans F45D11_39.B F45D11.12 F45D11.12 Protein of unknown function, putative paralog of C. elegans F45D11.8 F45D11.13 F45D11.13 Protein of unknown function, putative paralog of C. elegans F45D11_40.E F45D11.14 F45D11.14 Protein of unknown function, putative paralog of C. elegans F45D11.16 F45D11.15 F45D11.15 Protein of unknown function, putative paralog of C. elegans F45D11.14 F45D11.16 F45D11.16 Protein of unknown function, putative paralog of C. elegans F45D11.15 F45D11.2 F45D11.2 Protein of unknown function, putative paralog of C. elegans F45D11.3 F45D11.2, with F45D11.3 and F45D11.4, encodes a nematode-specific protein that entirely consists of one large (~300-residue) 'domain of unknown function' (DUF684) that is found in several other C. elegans proteins; a transcription unit of either F45D11.2, F45D11.3, or F45D11.4 (genes of essentially identical sequence) has a natural nonsense transcript that is up-regulated in vivo by smg[-] mutations, indicating that at least one of these three genes is a natural substrate for SMG-mediated nonsense suppresssion; F45D11.2 has no obvious function in mass RNAi assays, but, since several other natural mRNA substrates of SMG suppression (e.g., rpl-3, rpl-8, rpl-10a, rpl-12) have protein products that are involved in translation, F45D11.2 protein may may function in translation as well. F45D11.3 F45D11.3 Protein of unknown function, putative paralog of C. elegans F45D11.2 F45D11.3, with F45D11.2 and F45D11.4, encodes a nematode-specific protein that entirely consists of one large (~300-residue) 'domain of unknown function' (DUF684) that is found in several other C. elegans proteins; a transcription unit of either F45D11.3, F45D11.2, or F45D11.4 (genes of essentially identical sequence) has a natural nonsense transcript that is up-regulated in vivo by smg[-] mutations, indicating that at least one of these three genes is a natural substrate for SMG-mediated nonsense suppresssion; since several other natural mRNA substrates of SMG suppression (e.g., rpl-3, rpl-8, rpl-10a, rpl-12) have protein products that are involved in translation, F45D11.3 protein may may function in translation as well. F45D11.4 F45D11.4 Protein of unknown function, putative paralog of C. elegans F45D11.3 F45D11.4, with F45D11.2 and F45D11.3, encodes a nematode-specific protein that entirely consists of one large (~300-residue) 'domain of unknown function' (DUF684) that is found in several other C. elegans proteins; a transcription unit of either F45D11.4, F45D11.2, or F45D11.3 (genes of essentially identical sequence) has a natural nonsense transcript that is up-regulated in vivo by smg[-] mutations, indicating that at least one of these three genes is a natural substrate for SMG-mediated nonsense suppresssion; since several other natural mRNA substrates of SMG suppression (e.g., rpl-3, rpl-8, rpl-10a, rpl-12) have protein products that are involved in translation, F45D11.4 protein may may function in translation as well. F45D11.5 F45D11_40.I;F45D11.M;F45D11.5 Protein containing a BTB (BR-C, ttk and babor) or POZ (Pox virus and zinc finger) domain, which are found in some DNA and actin binding proteins and may mediate protein-protein interactions F45D11.6 F45D11.6 Putative paralog of C. elegans Y116F11B.G F45D11.8 F45D11.8 Protein of unknown function, putative paralog of C. elegans F45D11.12 F45D11.9 F45D11.9 Protein of unknown function, putative paralog of C. elegans F45D11_39.C F45D3.1 F45D3.1 Protein of unknown function F45D3.2 F45D3.2 Protein of unknown function F45D3.3 F45D3.3 Protein of unknown function, has high similarity to uncharacterized C. elegans F45D3.4 F45D3.4 F45D3.4 Protein of unknown function, has high similarity to uncharacterized C. elegans F45D3.3 F45D3.5 sel-1;F45D3.5 Protein that negatively influences LIN-12 and GLP-1 signaling perhaps by regulating turnover Yeast hypothetical gene L8167.5 like; sel-1 encodes two isoforms of a highly conserved transmembrane protein orthologous to human SEL1 (OMIM:602329) and Saccharomyces cerevisiae HRD3, a member of the HMG-CoA Reductase Degradation (HRD) complex that degrades malfolded endoplasmic reticulum (ER)-resident proteins; SEL-1 functions as a key negative regulator of the LIN-12/Notch-like signaling pathway in C. elegans where it appears to function cell autonomously to regulate LIN-12 turnover; along with ABU-1, an ER-associated Type I transmembrane protein, SEL-1 may be a component of a cell survival pathway induced when unfolded proteins accumulate in the ER; SEL-1 is expressed throughout larval and adult stages of development, and detected in all tissues except the pharynx; within cells, SEL-1 appears to localize to intracellular vesicles, consistent with its proposed role in protein turnover. F45E1.1 F45E1.1 Protein of unknown function F45E1.2 F45E1.2 Protein of unknown function F45E1.3 F45E1.3 Member of the haloacid dehalogenase or epoxide hydrolase family This gene encodes a protein predicted by Eisenberg and coworkers, with 52% accuracy, to be mitochondrial. F45E1.4 F45E1.4 Protein of unknown function F45E1.5 F45E1.5 Protein of unknown function F45E1.6 F45E1.6 Member of the histone H3 protein family Histone H3; his-71 encodes an H3 histone required for embryonic viability, body morphology, and larval viability. F45E1.7 F45E1.7 Protein containing a Fes or CIP4 homology domain and a Src homology 3 (SH3) domain, has low similarity to rat Pacsin2, which is protein kinase C and casein kinase substrate in neurons that is involved in endocytosis and actin cytoskeleton organization F45E10.1 F45E10.1 Protein of unknown function adaptor protein unc-53; UNC-53 encodes at least five large (~1200-1600 residue) proteins, orthologous to human NAV1, NAV2/RAINB1 (OMIM:607026), and NAV3, and homologous to Drosophila CG10662; UNC-53 proteins are required for anteroposterior guidance of migrating cells and axons, and for egg-laying, correct backward locomotion, full body size, and male mating; UNC-53 proteins vary in their N-terminal regions but share common C-terminal sequences with an AAA-ATPase domain; UNC-71 binds B0336.6 in a yeast two-hybrid screen, and interacts both physically and genetically with SEM-5; unc-53 is expressed in those cells requiring it, suggesting that its function is cell-autonomous; overexpression of unc-53 induces excess cellular outgrowth. F45E10.2 F45E10.2 Protein with strong similarity to D. melanogaster Orct (Organic cation transporter) sugar transporter F45E12.1 F45E12.1 Protein of unknown function, has strong similarity to H. sapiens Hs.84359 gene product F45E12.2 F45E12.2;BRF Putative general transcription factor (TFIIIB ) of RNA polymerase III transcription initiation factor IIB; BRF1 homolog, subunit of RNA polymerase transcription initiation factor IIIB (S. cerevisiae) BRF-1. F45E12.3 cul-4;F45E12.3 Member of the cullin family of cell cycle control proteins F45E12.4 F45E12.4 Protein of unknown function F45E12.5 F45E12.5 Protein of unknown function F45E12.6 F45E12.6 Protein of unknown function F45E4.1 arl-6;F45E4.1 Protein with high similarity to ADP-ribosylation factor 1 (human ARF1), which is a small guanine nucleotide-binding protein, member of the ADP-ribosylation factor (ARF) family, which are GTP-binding proteins involved in protein trafficking ADP-ribosylation factor; arl-6 encodes a member of the ADP-ribosylation factor family. F45E4.10 F45E4.10 Protein of unknown function gfi-4 encodes a novel protein that was identified in screens for proteins that interact with GEI-4, a coiled-coil domain protein required for embryonic viability, fertility, and vulval morphogenesis that also interacts with GEX-2, a putative Rac-binding protein, and intermediate filaments; based on its interaction with GEI-4, GFI-4 may be predicted to play a role in intermediate filament rearrangements during germline development or embryonic or vulval morphogenesis; however, as loss of gfi-4 activity via large-scale RNAi screens does not result in any obvious abnormalities, the precise role of GFI-4 in C. elegans development and/or behavior is not yet known. F45E4.11 F45E4.11 Protein with weak similarity to solute carrier family 17 member 1 (human SLC17A1), which is a sodium-dependent phosphate transporter that mediates organic anion transport at the renal apical membrane F45E4.2 F45E4.2 Protein with low similarity to purine rich element binding protein beta (mouse Purb), which binds single-stranded DNA and mouse Pura, represses vascular smooth muscle alpha-actin transcription, and may act in DNA replication initiation and mRNP formation F45E4.3 F45E4.3 Protein contains a putative protein kinase C conserved domain, has similarity to human Hs.153610, mRNA for KIAA0751 protein, isolated from a brain cDNA library F45E4.4 F45E4.4 Putative ortholog of C. elegans T23A7.B gene product F45E4.5 F45E4.5 Protein of unknown function F45E4.6 F45E4.6 Protein of unknown function F45E4.7 F45E4.7 Protein with weak similarity to neutral endopeptidases, has weak similarity across the middle region to human PEX, a metalloendopeptidase homolog, and to members of the C. elegans protease protein family F45E4.8 F45E4.8 FAFA neurotransmitter nlp-20 encodes a predicted neuropeptide of the FAFA family; expressed in pharyngeal neurons. F45E4.9 F45E4.9 Protein containing a high mobility group box (HMG1 or 2) family domain, has low similarity to transcription factor A mitochondrial (human TFAM), which regulates expression of mitochondrial genes and is involved in organelle biogenesis F45E6.1 F45E6.1 Protein of unknown function F45E6.2 F45E6.2 Protein of unknown function, has moderate similarity to H. sapiens Hs.171873/ATF6 gene product YIB9 like F45E6.3 F45E6.3 Protein containing a TBC domain, which may be GTPase activators of Rab-like small GTPases, has low similarity to uncharacterized human FLJ10743 Probable rabGAP domains F45E6.4 F45E6.4 Member of the class 2 lipase family, has high similarity to uncharacterized C. elegans C04B4.3 lipase F45E6.6 F45E6.6 Protein of unknown function, has high similarity to a region of C. elegans LIN-15B, which is a negative regulator of the C. elegans LET-23 receptor-tyrosine kinase, C. elegans LET-60 ras signaling pathway F45F2.1 F45F2.1 Protein of unknown function, has low similarity to uncharacterized C. elegans F45F2.5 F45F2.10 F45F2.10 Protein containing an ankyrin (Ank) repeat, which may mediate protein-protein interactions F45F2.11 F45F2.11 Protein of unknown function F45F2.12 his-8;F45F2.12 Member of the histone H2B protein family histone H2B; his-8 encodes an H2B histone; his-8 is contained within the histone gene cluster HIS2. F45F2.13 his-6;F45F2.13 Member of the histone H3 protein family histone H3; his-6 encodes an H3 histone. F45F2.2 his-39;his-29;F45F2.2 Protein with high similarity to H2B histone family member R (human H2BFR), which is a component of nucleosomes, along with core histones H2A, H3, H4, and DNA, member of the histone family of nucleosomal core proteins histone H4; his-39 encodes an H2B histone; by homology, HIS-39 is predicted to function as a nucleosome component required for packaging of DNA into chromatin; loss of his-39 function via RNA-mediated interference (RNAi) does not result in any abnormalities; his-39 is a replication-dependent histone locus that resides in the HIS2 cluster on chromosome V. F45F2.3 his-5;F45F2.3 Protein with very strong similarity to H4 histone family member E (human H4FE), which may play a role in the establishment and maintenance of chromatin architecture in nucleosomes, member of the histone family of nucleosomal core proteins histone H4; his-5 encodes an H4 histone. F45F2.4 his-7;F45F2.4 Member of the histone H2A protein family histone H2A; his-7 encodes an H2A histone. F45F2.5 F45F2.5 Protein of unknown function, has high similarity to uncharacterized C. elegans D1065.1 F45F2.6 F45F2.6 Protein of unknown function, has high similarity to uncharacterized C. elegans F45F2.5 F45F2.7 F45F2.7 Protein of unknown function, has high similarity to uncharacterized C. elegans H19J13.1 F45F2.9 F45F2.9 Protein with low similarity to S. cerevisiae Ybr242p, which is required for normal growth rate on glucose and for normal copper sensitivity F45G2.1 F45G2.1 Member of the astacin (M12A) family of metalloproteases, has low similarity to a region of meprin A beta subunit (rat Mep1b), which is an integral membrane protein and subunit of the meprin A heterodimer that may play a role in embryogenesis zinc metallopeptidase (M12A family) F45G2.10 F45G2.10 Protein containing a DUF59 domain of unknown function, has high similarity to uncharacterized human LOC51647 F45G2.2 F45G2.2 Protein containing a myosin head domain (motor domain), a myosin N-terminal SH3-like domain, and a coiled-coil myosin heavy chain tail region, has moderate similarity to S. pombe Myo2p, which is an essential myosin heavy chain Myosin head (motor domain) (contains ATP/GTP binding P-loop) F45G2.3 F45G2.3 Protein containing a Xeroderma pigmentosum group G (XPG) N-terminal domain and an XPG I-region (Xeroderma pigmentosum group G internal region) domain, which function in DNA excision repair, has low similarity to DNA exonuclease (S. pombe Exo1p) XPG N-terminal domain, XPG I-region F45G2.4 F45G2.4 Protein of unknown function, has moderate similarity to uncharacterized coatomer protein complex subunit epsilon (human leukocyte vacuolar sorting protein, human COPE) F45G2.4 encodes an epsilon subunit of the coatomer (COPI) complex; in mass RNAi assays, F45G2.4 is required for larval viability, proper locomotion, and properly rapid growth. F45G2.5 F45G2.5 Protein containing one kunitz or bovine pancreatic trypsin inhibitor domain Uncloned locus that affects the integrity of the cuticle and the development of the bursa in the adult male. F45G2.6 trf-1;F45G2.6;CeTRAF Protein with strong similarity to TNF receptor-associated factors Zinc finger, C3HC4 type (RING finger); The trf-1 gene encodes a protein with a meprin-associated Traf homology (MATH) domain that may be involved in apoptosis. F45G2.7 F45G2.7 Protein of unknown function F45G2.8 F45G2.8 Protein of unknown function, has high similarity to uncharacterized human MAGMAS F45G2.9 F45G2.9 Member of the FtsJ-like methyltransferase family, has weak similarity to S. cerevisiae Mrm2p, which is a methyltransferase that methylates mitochondrial 21S rRNA at nucleotide U2791 F45H10.1 F45H10.1 Member of the aldehyde dehydrogenase protein family succinate semi-aldehyde dehydrogenase; alh-7 encodes an ortholog of the human gene DJ73M23.2 (NAD+-DEPENDENT SUCCINIC SEMIALDEHYDE DEHYDROGENASE; ALDH5A1), which when mutated leads to SSADH deficiency (OMIM:271980). F45H10.2 F45H10.2 Member of the UcrQ ubiquinol-cytochrome C reductase family, has strong similarity to uncharacterized C. elegans R07E4.3 F45H10.3 F45H10.3 Protein with weak similarity to H. sapiens NDUFA7 (NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 7 (14.5kD, B14.5a)) Weak similarity with NADH-ubiquinone oxidoreductase subunit (Swiss Prot accession number Q05752) F45H10.4 F45H10.4 Protein of unknown function F45H11.1 F45H11.1 Protein containing a C2H2 type zinc finger domain, which bind nucleic acids, has a region of low similarity to a region of trans-acting transcription factor 4 (human SP4), which is a transcriptional repressor Zinc finger, C2H2 type F45H11.2 ned-8;F45H11.2 Member of the ubiquitin family that has a role in seam cell differentiation ubiquitin; The ned-8 gene encodes a ubiquitin-like protein that is required for both embryogenesis and terminal hypodermal differentiation. F45H11.3 F45H11.3 Protein of unknown function F45H11.4 mgl-2;F45H11.4 Member of the metabotrobic glutamate family of G-protein coupled receptors and the bZIP Maf transcription factor family, contains a receptor family ligand binding domain, has moderate similarity to metabotropic glutamate receptor 1 alpha (human GRM1) metabotropic glutamate receptor; mgl-2 encodes a Group I metabotropic glutamate receptor (OMIM:604473, 604102, loss-of-function mutations in mice are associated with defects in long-term potentiation); by homology, MGL-2 is predicted to function as a post-synaptic G protein-coupled receptor that, in response to glutamate binding, stimulates phospholipase C activity and increases neuronal excitation, and in mammalian tissue culture cells, glutamate stimulation of MGL-2 does result in increased phosphoinositide turnover; a mutation in mgl-2 indicates that it is required for normal head movements and tap reversal reflexes, while loss of mgl-2 activity via large-scale RNAi screens indicates that MGL-2 is also required for embryogenesis; a mgl-2::GFP reporter is expressed in interneurons. F45H11.5 F45H11.5 Protein of unknown function F45H7.1 F45H7.1 Protein of unknown function F45H7.3 gei-1;F45H7.2;F45H7.3 Protein containing two RhoGAP (GTPase activator protein) domains, has a region of low similarity to a region of deleted liver cancer 1 (human DLC1), which is a putative GTPase activator involved in cell proliferation F45H7.4 prk-2;F45H7.4 Protein with high similarity to proviral integration site 1 (mouse Pim1), which is a serine-threonine protein kinase that helps to promote G1 to S transition and prevention of apoptosis, contains a protein kinase domain serine/threonine kinase F45H7.6 F45H7.6 Protein containing two WW domains, which bind proline-rich peptide epitopes, and a HECT domain, which may confer ubiquitin-protein ligase activity, has low similarity to neural cell precursor expressed developmentally down regulated 4 (human NEDD4) Yeast ORF YKL162 F46A8.1 F46A8.1 Protein of unknown function, has high similarity to uncharacterized C. elegans K08D10.10 F46A8.10 F46A8.10 Protein of unknown function, has a region of low similarity to plasma membrane phospholipid scramblase 1 (mouse Plscr1), which mediates Ca2+-dependent movement of membrane phospholipids and is a substrate of tyrosine kinase c-Abl F46A8.10 encodes a homolog of human scramblase (PLSCR1; OMIM:604170), which is activated by a rise of intracellular calcium, and which promotes the exposure of phosphatidylserine on the surface of cells undergoing activation, injury, or apoptosis; paralogs of F46A8.10 include F46A8.9, K08D10.7, K08D10.8, and Y50E8A.9. F46A8.2 F46A8.2 Protein of unknown function, has low similarity to uncharacterized C. elegans F56D6.1 F46A8.3 F46A8.3 Member of the galectin family, which are lectins that bind beta galactosides, has high similarity to uncharacterized C. elegans F49F1.11 Vertebrate galactoside-binding lectins F46A8.4 F46A8.4 Member of the galectin family, which are lectins that bind beta galactosides, has strong similarity to uncharacterized C. elegans F49F1.10 Vertebrate galactoside-binding lectins F46A8.5 F46A8.5 Protein of unknown function, has high similarity to uncharacterized C. elegans F46A8.8 F46A8.6 F46A8.6 Protein of unknown function, has weak similarity to C. elegans Y50E8A.P F46A8.7 F46A8.7 Protein of unknown function F46A8.8 F46A8.8 Protein of unknown function, putative paralog of C. elegans F49F1.11 F46A8.9 F46A8.9 Putative ortholog of C. elegans K08D10.8 gene product F46A8.9 encodes a homolog of human scramblase (PLSCR1; OMIM:604170), which is activated by a rise of intracellular calcium, and which promotes the exposure of phosphatidylserine on the surface of cells undergoing activation, injury, or apoptosis; paralogs of F46A8.9 include F46A8.10, K08D10.7, K08D10.8, and Y50E8A.9. F46A9.1 F46A9.1 Protein of unknown function, has high similarity to uncharacterized C. elegans F46A9.2 F46A9.2 F46A9.2 Protein of unknown function, has high similarity to uncharacterized C. elegans F46A9.1 F46A9.3 F46A9.3 Protein of unknown function, has a region of weak similarity to a region of potassium channel subfamily K member 5 (human KCNK5), which is an ion channel that elicits currents that are blocked by local anesthetics potassium channel protein F46A9.4 skr-2;F46A9.4 Member of the Skp1 family, which are required for targeted protein degradation during the cell cycle, has high similarity to a region of S. cerevisiae Skp1p, which is a component of the Cbf3 kinetochore and SCF (Skp1p-cullin-F-box) complexes cyclin A/CDK2-associated protein P19 like; skr-2 encodes a homolog of Skp1 in S. cerevisiae, a core component of the SCF (Skp1p, Cullin, F-box) ubiquitin-ligase complex that facilitates ubiquitin-mediated protein degradation; SKR-2 is required for the restraint of cell proliferation, progression through the pachytene stage of meiosis, and the formation of bivalent chromosomes at diakinesis; SKR-2::GFP is detected exclusively in the intestine. F46A9.5 skr-1;F46A9.5 Member of the Skp1 family, which are required for targeted protein degradation during the cell cycle, has high similarity to a region of S. cerevisiae Skp1p, which is a component (subunit d) of Cbf3 kinetochore complex cyclin A/CDK2-associated protein P19 like; The skr-1 gene encodes a homolog of Skp1 in S. cerevisiae that is required for the restraint of cell proliferation, progression through the pachytene stage of meiosis, and the formation of bivalent chromosomes at diakinesis. F46A9.6 mec-8;C17E4.11;F46A9.6 Putative RNA-binding protein involved in neuronal development and mechanosensory responses mecanosensory gene mec-8 F46B3.1 F46B3.1 Protein of unknown function, has high similarity to uncharacterized C. elegans F46B3.2 F46B3.11 F46B3.11 Protein containing a DUF216 domain of unknown function, has high similarity to uncharacterized C. elegans F46B3.12 F46B3.12 F46B3.12 Protein containing a DUF216 domain of unknown function, has high similarity to uncharacterized C. elegans F46B3.11 F46B3.14 F46B3.14 Protein with moderate similarity to C. elegans F46B3.9 F46B3.15 F46B3.15 Protein of unknown function F46B3.16 F46B3.16 Protein with strong similarity to C. elegans F25E5.5 gene product F46B3.2 F46B3.2 Protein of unknown function, has high similarity to uncharacterized C. elegans F46B3.1 F46B3.3 F46B3.3 Member of the transthyretin-like family, has low similarity to uncharacterized C. elegans T08A9.2 Transthyretin-like family (2 domains) F46B3.4 F46B3.4 Member of the transthyretin-like family Transthyretin-like family F46B3.5 grd-2;F46B3.5 Putative paralog of C. elegans GRD-1, contains a Hint (hedgehog/intein) domain grd-2 encodes a predicted secreted protein that is similar to vertebrate desert hedgehog (Dhh) proteins (OMIM:605423, mutated in partial gonadal dysgenesis accompanied by minifascicular neuropathy); by homology, GRD-2 is predicted to be involved in cell communication, but as loss of grd-2 activity via RNA-mediated interference (RNAi) does not result in any obvious abnormalities, the precise role of GRD-2 in C. elegans development and/or behavior is not yet known; the grd-2 expression pattern has not been reported. F46B3.7 F46B3.7 Protein of unknown function, has high similarity to uncharacterized C. elegans F46B3.8 F46B3.8 F46B3.8 Protein of unknown function, has high similarity to uncharacterized C. elegans F46B3.7 F46B3.9 F46B3.9 Protein of unknown function, has weak similarity to a region of notch (Drosophila) homolog 2 (mouse Notch2), which is a transmembrane receptor involved in cell fate determination during embryogenesis and morphogenesis F46B6.10 F46B6.10 Protein of unknown function, has moderate similarity to uncharacterized C. elegans Y47D9A.4 F46B6.11 F46B6.11 Protein containing a DUF215 domain of unknown function, has high similarity to uncharacterized C. elegans C50C10.1 F46B6.12 F46B6.12 Protein of unknown function F46B6.2 F46B6.2 Protein of unknown function F46B6.3 smg-4;mab-14;F46B6.3 Involved in nonsense-mediated mRNA decay F46B6.4 F46B6.4 Protein of unknown function, has low similarity to uncharacterized pseudoautosomal GTP-binding protein-like (human PGPL), which is a putative GTP-binding protein that may positively regulate cell proliferation and may play a role in prostate cancer GTP-binding protein F46B6.5 F46B6.5 Protein of unknown function F46B6.6 F46B6.6 Protein containing an elongation factor Tu GTP binding domain, and an elongation factor Tu domain 2, which are involved in binding to charged tRNA, has low similarity to mitochondrial translation initiation factor 2 (S. cerevisiae Ifm1p) initiation factor IF-2 F46B6.7 F46B6.7 Protein containing three C2H2 type zinc finger domains, which bind nucleic acids, has moderate similarity to uncharacterized human ZNF277 Zinc finger, C2H2 type F46B6.8 F46B6.8 Member of the alpha or beta hydrolase fold family, has moderate similarity to lipase gastric (human LIPF), which is a serine esterase lipase that catalyzes the hydrolysis of dietary triacylglycerol substrates and may be inhibited by orlistat lipase F46B6.9 F46B6.9 Protein of unknown function F46C3.1 pek-1;CePEK;PERK;F46C3.1 Protein kinase that regulates translation initiation by phosphorylating initiation factor eIF-2alpha; involved in stress response eukaryotic translation initiation factor 2 alpha kinase PEK; pek-1 encodes a predicted transmembrane protein kinase orthologous to human eukaryotic translation initiation factor 2-alpha kinase 3 (EIF2AK3, OMIM:604032), which when mutated leads to Wolcott-Rallison syndrome; PEK-1 is strongly expressed in intestinal cells and is required for the unfolded protein response (UPR) that counteracts cellular stress induced by accumulation of unfolded proteins in the endoplasmic reticulum (ER); PEK-1 may function in the endoplasmic reticulum to phosphorylate eIF2alpha and inhibit protein synthesis in response to endogenous ER stress. F46C3.2 F46C3.2 Protein of unknown function F46C3.3 hum-4;F46C3.3 Myosin I, class XII unconventional myosin heavy chain myosin like; hum-4 encodes a class XII myosin, an unconventional myosin. F46C5.1 F46C5.1 Protein of unknown function F46C5.2 F46C5.2 Protein of unknown function that may be anchored to the membrane of a secretory vesicle or the Golgi apparatus F46C5.3 F46C5.3 Member of the astacin (M12A) family of metalloproteases, has low similarity to a region of C. elegans HCH-1, which is a putative zinc-dependent metalloprotease zinc metalloprotease F46C5.4 F46C5.4 Protein of unknown function F46C5.6 F46C5.6 Protein containing five HEAT repeat domains, which appear to function as protein-protein interaction surfaces, has low similarity to uncharacterized human KIAA1622 protein phosphatase PP2A subunit A repeat F46C5.7 F46C5.7 Protein of unknown function F46C5.8 F46C5.8 Protein with high similarity to S. cerevisiae Rer1p, which is a component of COPII-coated vesicles that is involved in retrieval of endoplasmic reticulum membrane proteins from the early Golgi compartment endoplasmic reticular protein F46C5.9 F46C5.9 Protein containing five WD domains (WD-40 repeat), which may mediate protein-protein interactions, has a region of low similarity to a region of S. pombe Tup12p, which is a transcriptional repressor G-protein F46C8.1 F46C8.1 Protein of unknown function F46C8.2 F46C8.2 Protein containing two collagen triple helix repeats, which are found in some extracellular proteins, and a nematode cuticle collagen N-terminal domain, has a region of moderate similarity to collagen type II alpha 1 (human COL2A1) cuticle collagen F46C8.3 F46C8.3 Protein of unknown function F46C8.5 ceh-14;F46C8.5 LIM homeodomain transcription factor, involved in thermosensation and thermotaxis LIM homeobox protein; ceh-14 is orthologous to the human gene LIM HOMEOBOX PROTEIN 3 ISOFORM B (LHX3; OMIM:600577), which when mutated leads to disease. F46C8.6 dpy-7;F46C8.6 Cuticle collagen; member of the collagen triple helix repeat (20 copies) family cuticle collagen F46C8.7 F46C8.7 Protein of unknown function, has weak similarity to uncharacterized C. elegans R11H6.3 F46C8.8 F46C8.8 Protein of unknown function F46E10.11 F46E10.B;F46E10.11 Protein of unknown function, has low similarity to uncharacterized C. elegans C43F9.5 F46E10.3 F46E10.3 Protein with strong similarity to C. elegans Y106G6H.9 gene product F46E10.6 W01A11.7;F46E10.6 Protein of unknown function, putative paralog of C. elegans F46E10.G F46E10.D F46E10.10;F46E10.D Protein containing a lactate or malate dehydrogenase NAD binding domain and a lactate or malate dehydrogenase alpha-beta C-terminal domain, has high similarity to uncharaterized cytosolic malate dehydrogenase (human MDH1) F46E10.E dpy-11;F46E10.9;F46E10.E Member of the thioredoxin family F46E10.F F46E10.8;F46E10.F Member of the ubiquitin carboxyl-terminal hydrolase family, which are cysteine proteases involved in deubiquination, has moderate similarity to ubiquitin carboxyl-terminal hydrolase L3 (human UCHL3), which functions as a C-terminal peptidase F46E10.J F46E10.2;F46E10.J Protein with weak similarity to H. sapiens COL4A4 (collagen, type IV, alpha 4) F46F11.1 F46F11.1 Protein of unknown function, has a region of low similarity to S. pombe Asp1p, which is a cytoplasmic factor required for polarized cell growth F46F11.10 F46F11.10 Protein with moderate similarity to C. elegans F25H8.1 gene product F46F11.2 F46F11.2 Protein containing a cold-shock nucleic acid binding domain, which bind both single-stranded DNA and single-stranded RNA, has a region of moderate similarity to a region of cold shock domain protein A (mouse Csda), which is a transcriptional repressor cey-2 encodes a cold-shock/Y-box domain-containing protein; by homology, CEY-2 is predicted to function as either an RNA-binding protein involved in translation or RNA processing, or a DNA-binding protein involved in transcriptional regulation; cey-2 mRNA is expressed maternally in the early embryo, in a pattern characteristic of class II maternal RNAs, which are initially detected throughout the embryo but restricted to the P, or germline, lineage as cell division progresses; as loss of cey-2 activity via large-scale RNAi screens does not result in any obvious abnormalities, the precise role of cey-2 in C. elegans development and/or behavior is not yet known. F46F11.3 F46F11.3 Protein of unknown function, has moderate similarity to a region of tensin (human TNS), which is required for extracellular matrix contact formation and fibronectin (human FN1) fibrillogenesis and is associated with breast and prostate cancer F46F11.4 F46F11.4 Member of the ubiquitin family, has strong similarity to uncharacterized human UBL5 This gene encodes an ortholog of the human ubiquitin-like gene UBL5, which is a distinct cytoplasmic paralog of nuclear ubiquitin or ubiquitin-like proteins. F46F11.5 F46F11.5 Putative ATPase subunit, has strong similarity to S. cerevisiae vacuolar ATPase G subunit Vma10p and human ATP6GL vacuolar ATPase G subunit F46F11.6 F46F11.6 Protein containing an F-box domain, which serve as a link between a target protein and a ubiquitin-conjugating enzyme F46F11.7 F46F11.7 Protein of unknown function, has a region of low similarity to a region of tenascin C (hexabrachion, mouse Tnc), which is a multidomain extracellular matrix glycoprotein that has effects on cell proliferation and migration and may have a role in adhesion F46F11.8 F46F11.8 Protein of unknown function, has moderate similarity to C. elegans F25H8.1 F46F11.9 F46F11.9 Protein of unknown function F46F2.1 F46F2.1 Protein of unknown function, has high similarity to uncharacterized C. elegans T22B2.1 Zinc finger, C3HC4 type (RING finger) F46F2.2 kin-20;F46F2.2 Protein related to casein kinase 1 casein kinase I (epsilon/delta) F46F2.3 F46F2.3 Protein of unknown function F46F2.4 F46F2.4 Protein of unknown function, has high similarity to a region of C. elegans LIN-15B, which is a negative regulator of the C. elegans LET-23 receptor-tyrosine kinase, C. elegans LET-60 ras signaling pathway lin-15B like F46F3.1 F46F3.1 Protein containing a homeobox domain (homeodomain), which are found in transcription factors, has a region of high similarity to a region of drosophila NK2 transcription factor related locus 3 (mouse Nkx2-3), which is a transcription factor homeobox protein (NK-2 subfamily); ceh-27 encodes a homeodomain protein of the NK-2 class that contains Drosophila scarecrow and human NKX-2 (OMIM:606727); CEH-27 activity is essential for embryogenesis and appears to be required for maintaining hypodermal integrity during movement as embryos lacking CEH-27 burst at a breach in the ventral hypodermis upon commencement of muscle contractions; CEH-27 expression is first detected in the ~100-cell embryo in what appear to be MS-derived cells while in later embryos expression is seen in a number of cells in the anterior head region. F46F3.2 F46F3.2 Protein containing a neurotransmitter-gated ion-channel ligand binding domain, has a region of low similarity to glycine receptor alpha 1 (rat Glra1), which is part of a glycine-gated chloride channel that is important for inhibitory neurotransmission gamma-aminobutyric-acid receptor F46F3.3 F46F3.3 Resembles a p53-binding protein F46F3.4 F46F3.4 Protein containing two ankyrin (Ank) repeats and a Src homology 3 (SH3) domain, has a region of low similarity to a region of TP53 binding protein 2 (human TP53BP2), which is a DNA damage-inducible protein that promotes DNA damage-induced apoptosis P53-binding protein like F46F5.1 F46F5.1 Putative ortholog of C. elegans T04B8.1 gene product F46F5.10 F46F5.10 Protein containing a DUF235 domain of unknown function, has high similarity to uncharacterized C. elegans Y45G12C.1 F46F5.11 F46F5.11 Protein of unknown function, has high similarity to uncharacterized C. elegans ZK105.3 F46F5.12 F46F5.12 Protein of unknown function, has high similarity to uncharacterized C. elegans F32B5.3 F46F5.13 F46F5.13 Protein of unknown function, has low similarity to uncharacterized C. elegans K07E8.1 membrane protein F46F5.14 F46F5.14 Protein of unknown function, has high similarity to uncharacterized C. elegans ZK1055.2 F46F5.15 F46F5.15 Protein of unknown function, has weak similarity to C. elegans R07C3.13 F46F5.16 F46F5.16 Protein of unknown function, has weak similarity to C. elegans Y40B10B.B F46F5.2 F46F5.2 Protein containing one Src homology 2 (SH2) domain, which are regulatory modules of intracellular signaling and one protein kinase domain, has low similarity to tec protein tyrosine kinase (mouse Tec), which is involved in T cell receptor signaling protein kinase F46F5.4 F46F5.4 Protein of unknown function, has high similarity to uncharacterized C. elegans F46F5.14 F46F5.5 F46F5.5 Protein with strong similarity to C. elegans Y39F10B_187.A gene product F46F5.6 F46F5.6 Protein of unknown function, has high similarity to uncharacterized C. elegans D2062.6 F46F5.7 F46F5.7 Protein containing a DUF138 domain of unknown function, has strong similarity to uncharacterized C. elegans T05B11.4 F46F5.8 F46F5.8 Protein with moderate similarity to C. elegans Y116F11.X gene product F46F5.9 F46F5.9 Protein of unknown function, has high similarity to uncharacterized C. elegans D2062.6 F46F6.1 F46F6.1 Protein containing a DENN (AEX-3) domain, has a region of low similarity to a region of suppression of tumorigenicity 5 (human ST5), which is involved in the regulation of MAPK and in maintaining contact dependent growth F46F6.2 F46F6.2 Protein containing an Hr1 repeat motif, which are alpha-helical domains that bind Rho proteins, a protein kinase domain, and a protein kinase C-terminal domain, has moderate similarity to protein kinase C-like 2 (human PRKCL2), which is a kinase Protein kinase C terminal domain F46F6.3 F46F6.3 Protein of unknown function F46G10.1 F46G10.1 Protein of unknown function, has weak similarity to C. elegans F47D12.3 F46G10.2 F46G10.2 Protein of unknown function F46G10.3 F46G10.3 Member of the Sir2 family, which are silent information regulators, has low similarity to S. cerevisiae Hst2p, which is involved in transcriptional silencing of chromatin SIR F46G10.4 F46G10.4 Member of the lipase protein family lipase F46G10.5 F46G10.5 Member of the patched family, which are transmembrane receptors ptr-24 encodes a member of the Patched superfamily. F46G10.6 F46G10.6 Protein containing a helix-loop-helix DNA-binding domain, which mediate protein dimerization, has a region of high similarity to MAX protein (human MAX), which forms homodimers or heterodimers with human MYC or human MAD that regulate transcription Helix-loop-helix DNA-binding domain F46G10.7 F46G10.7 Member of the Sir2 family, which are silent information regulators, has low similarity to S. cerevisiae Hst2p, which is involved in histone deacetylation and chromosome organization and biogenesis SIR; sir-2.2 encodes a member of the conserved SIR2-like family of proteins that function in chromatin organization and remodeling; SIR-2.2 may play a role in genomic stability and protecing the genome against mutations, as loss of SIR-2.2 function via RNA-mediated interference (RNAi) results in an increased level of spontaneous mutagenesis. F46G11.1 F46G11.1 Protein of unknown function F46G11.1 is orthologous to the human gene TRUNCATED PUTATIVE T7-LIKE MITOCHONDRIAL DNA HELICASE (C10orf2; OMIM:606075), which when mutated leads to disease. F46G11.2 F46G11.2 Protein of unknown function F46G11.3 F46G11.3 Protein containing a protein kinase domain, has low similarity to microtubule- and MAP-affinity regulating kinase (rat LOC60328), which is a serine-threonine kinase that participates in microtubule stability and the control of cell polarity serine/threonine-protein kinase F46G11.4 F46G11.4 Protein of unknown function F46H5.1 F46H5.1 Protein of unknown function F46H5.2 F46H5.2 Protein of unknown function F46H5.3 F46H5.3 Protein containing an ATP:guanido phosphotransferase C-terminal catalytic domain and a plant ATP-guanido phosphotransferase N-terminal domain, has moderate similarity to creatine kinase (muscle form) (mouse Ckmm), which is important for energy homeostasis arginine kinase F46H5.4 F46H5.4 Protein of unknown function, has low similarity to uncharacterized human KIAA1395 Rat trg gene product F46H5.5 F46H5.5 Protein of unknown function F46H5.6 grd-7;F46H5.6 Protein with strong similarity to C. elegans GRD-6, has weak similarity to C. elegans MUC1, transmembrane mucin 1 grd-7 encodes a predicted secreted protein that is a member of the C. elegans groundhog gene family; by homology, GRD-7 is predicted to be involved in cell communication, but the precise role of grd-7 in C. elegans development and/or behavior is not yet known; a grd-7 reporter gene is expressed in three to four posterior DA motor neurons of the ventral nerve cord. F46H5.7 F46H5.7 Protein of unknown function, has weak similarity to uncharacterized C. elegans C27H5.2 F46H5.8 F46H5.8 Protein of unknown function, has weak similarity to uncharacterized C. elegans C33F10.7 F46H6.1 rhi-1;CeRhoGDI;F46H6.1 Protein with sequence similarity to Rho GDP dissociation inhibitors; GDP dissociation from C. elegans Rho-GTPases is inhibited in the presence of CeRhoGDI rho GDP dissociation inhibitor F46H6.2 F46H6.2 Putative diacylglycerol kinase, has strong similarity to H. sapiens DGKE (diacylglycerol kinase epsilon, 64kD) diaglycerol kinase; dgk-2 encodes a putative diacylglycerol kinase. F46H6.4 F46H6.4 Protein of unknown function F47A4.1 F47A4.1 Protein containing a neurotransmitter-gated ion-channel ligand binding domain, has low similarity to rho 1 subunit of the gamma-aminobutyric acid A (GABA) receptor (human GABRR1), which is involved in decreasing neuronal sensitivity to neurotransmitters ligand gated ion channel F47A4.2 sop-1;F47A4.2 Putative component of a transcriptional Mediator complex that regulates responses to a Wnt signal transduction pathway dpy-22 encodes a broadly expressed protein, homologous to the human transcriptional mediator protein TRAP230, which is involved in WNT and RAS signaling, as well as in dosage compensation; DPY-22 has a C-terminal glutamine-rich domain that is dispensable for inhibition of RAS-dependent cell differentiation, but is required for inhibition of BAR-1-dependent gene expression. F47A4.3 F47A4.3 Protein containing a RhoGAP (GTPase activator protein) domain, has a region of moderate similarity to a region of cdc42 GTPase-activating protein (mouse Cdgap), which acts on Cdc42 and Rac but not Rho and and functions in actin reorganization breakpoint cluster region (BCR) protein domain F47A4.5 F47A4.5 Member of the palatin family, contains six ankyrin (Ank) repeats, has a region of low similarity to group VI phospholipase A2 (human PLA2G6), which is a cytosolic calcium-independent phospholipase that stimulates arachidonate release patatin domain and ankyrin-like domain F47B10.1 scb1;F47B10.1 Protein with high similarity to succinyl-CoA ligase (S. cerevisiae Lsc2p), which is the beta subunit of succinyl-CoA synthetase complex, member of the ATP-citrate lyase or succinyl-CoA ligase family, contains an ATP-grasp domain succinate-CoA ligase; This gene encodes a protein predicted by Eisenberg and coworkers, with 68% accuracy, to be mitochondrial. F47B10.2 F47B10.2 Protein with high similarity to histidine ammonia-lyase (histidase, rat Hal), which deaminates histidine to form urocanic acid, member of the phenylalanine and histidine ammonia-lyase (PAL) family, which are involved in phenylpropanoid metabolism histidine ammonia-lyase; F47B10.2 is orthologous to the human gene HISTIDASE (HAL; OMIM:235800), which when mutated leads to disease. F47B10.3 F47B10.3 Protein of unknown function F47B10.4 F47B10.4 Protein of unknown function F47B10.5 F47B10.5 Protein of unknown function F47B10.6 F47B10.6 Protein of unknown function F47B10.7 F47B10.7 Protein containing an acyl CoA binding domain, has a region of moderate similarity to diazepam binding inhibitor (acyl-CoA-binding protein, rat Dbi), which displaces diazepam from type A GABA receptors and may transport Acyl-CoA acyl-CoA-binding protein F47B10.8 F47B10.8 Protein of unknown function F47B10.9 F47B10.9 Protein of unknown function, has high similarity to uncharacterized C. elegans F56C3.9 F47B3.1 F47B3.1 Member of the protein-tyrosine phosphatase family, which are involved in control of cell growth, proliferation, differentiation and transformation, has moderate similarity to C. elegans F10G8.1, which is involved in embryogenesis or morphogenesis protein-tyrosine phosphatase F47B3.2 F47B3.2 Member of the protein-tyrosine phosphatase family, which are involved in control of cell growth, proliferation, differentiation and transformation, has low similarity to a region of human PTPN6, which is a non-receptor type protein tyrosine phosphatase F47B3.3 F47B3.3 Putative ortholog of C. elegans F28H1.4 gene product F47B3.4 F47B3.4 Protein containing a DUF236 domain of unknown function, has strong similarity to uncharacterized C. elegans ZC376.8 F47B3.5 F47B3.5 Protein containing a DUF236 domain of unknown function, has high similarity to uncharacterized C. elegans F47B3.4 F47B3.6 F47B3.6 Member of the protein-tyrosine phosphatase family, which are involved in control of cell growth, proliferation, differentiation and transformation, has moderate similarity to C. elegans F10G8.1, which is involved in embryogenesis or morphogenesis F47B3.7 F47B3.7 Member of the protein-tyrosine phosphatase family, which are involved in control of cell growth, proliferation, differentiation and transformation, has moderate similarity to C. elegans F10G8.1, which is involved in embryogenesis or morphogenesis F47B3.8 F47B3.8 Protein containing a class B low-density lipoprotein (LDL) receptor repeat and a LDL receptor class A domain, has low similarity to a region of low density lipoprotein receptor-related protein 1 (human LRP1), which binds to apoE-containing lipoproteins EGF-like protein F47B7.1 F47B7.1 Member of the uncharacterized protein family UPF0057, has high similarity to uncharacterized C. elegans C04G6.5 F47B7.2 F47B7.2 Member of the thioredoxin family, which are small enzymes involved in redox reactions, has low similarity to quiescin Q6 (FAD-dependent sulfhydryl oxidase, rat Qscn6) F47B7.3 F47B7.3 Protein containing a DUF130 domain of unknown function, has high similarity to uncharacterized C. elegans F16G10.8 F47B7.4 F47B7.4 Protein containing a DUF130 domain of unknown function, has strong similarity to uncharacterized C. elegans F16G10.11 F47B7.5 F47B7.5 Protein containing a DUF130 domain of unknown function, has high similarity to uncharacterized C. elegans F16G10.13 F47B7.6 F47B7.6 Protein of unknown function F47B7.7 F47B7.7 Protein of unknown function F47B8.1 F47B8.1 Protein of unknown function, has high similarity to uncharacterized C. elegans F47B8.2 F47B8.10 F47B8.10 Member of the sugar (and other) transporter family, has low similarity to glucose-6-phosphate translocase (rat G6pt1), which is a component of glucose-6-phosphatase enzyme complex F47B8.10 is orthologous to the human gene GLUCOSE-6-PHOSPHATE TRANSPORTER 1 (G6PT1; OMIM:602671), which when mutated leads to type Ib glycogen storage disease. F47B8.11 F47B8.11 Protein of unknown function, has high similarity to uncharacterized C. elegans T13F2.9 F47B8.2 F47B8.2 Protein of unknown function, has high similarity to uncharacterized C. elegans F47B8.1 F47B8.3 F47B8.3 Protein of unknown function, has high similarity to uncharacterized C. elegans F47B8.4 F47B8.4 F47B8.4 Protein of unknown function, has high similarity to uncharacterized C. elegans F47B8.3 F47B8.5 F47B8.5 Member of the domain of unknown function DUF13 family, has a region of low similarity to a region of heavy polypeptide of neurofilament (mouse Nfh), which is a structural protein that may regulate synaptic transmission, and intermediate filament assembly F47B8.6 F47B8.6 Protein of unknown function, has high similarity to uncharacterized C. elegans F47B8.8 F47B8.7 F47B8.7 Protein of unknown function, has weak similarity to uncharacterized C. elegans T28H11.2 F47B8.8 F47B8.8 Member of the M1 peptidase family of aminopeptidases, has high similarity to uncharacterized C. elegans F47B8.6 F47B8.9 F47B8.9 Putative ortholog of C. elegans F47B8.7 gene product 7TM receptor, srm family F47C10.1 F47C10.1 Protein containing a nuclear hormone receptor C4-type zinc finger domain, which bind DNA and may be involved in regulation of transcription, and a nuclear hormone receptor ligand-binding domain, has low similarity to C. elegans NHR-51 F47C10.2 F47C10.2 Protein containing a BTB (BR-C, ttk and babor) or POZ (Pox virus and zinc finger) domain, which are found in some DNA and actin binding proteins and may mediate protein-protein interactions, has high similarity to uncharacterized C. elegans F59H6.12 F47C10.3 F47C10.3 Protein containing two nuclear hormone receptor C4-type zinc finger domains, which bind DNA and may be involved in regulation of transcription, and a nuclear hormone receptor ligand-binding domain, has low similarity to C. elegans NHR-51 nuclear hormone receptor F47C10.4 F47C10.4 Protein containing a nuclear hormone receptor C4-type zinc finger domain, which bind DNA and may be involved in regulation of transcription, and a nuclear hormone receptor ligand-binding domain, has low similarity to C. elegans NHR-51 F47C10.6 F47C10.6 Protein containing four UDP-glucoronosyl and UDP-glucosyl transferase domains, has low similarity to olfactory UDP-glucuronosyltransferase (human UGT2A1), which catalyzes the glucuronidation of substrates such as odorants, steroids, drugs, and carcinogens UDP-glucuronosyltransferase F47C10.7 F47C10.7 Member of the nuclear hormone receptor/Zinc finger protein family F47C10.8 F47C10.8 Member of the nuclear hormone receptor/Zinc finger protein family nuclear hormone receptor F47C12.1 F47C12.1 Protein containing seven sushi or short consensus repeat (SCR), five epidermal growth factor (EGF)-like, two hyalin repeat (HYR), CUB, and F5 or 8 type C (discoidin) domains, has a region of low similarity to a region of mouse Notch4 F47C12.10 F47C12.10 Member of the 7-transmembrane chemoreceptor family of G protein-coupled receptors (GPCR), has high similarity to uncharacterized C. elegans F47C12.3 7TM chemoreceptor, srh family F47C12.2 F47C12.2 Member of the C-type lectin family, has similarity to human cubulin (intrinsic factor-cobalamin receptor) and bone morphogenetic protein BMP1, has similarity to D. melanogaster tolkin protein F47C12.3 F47C12.3 Member of the 7-transmembrane chemoreceptor family of G protein-coupled receptors (GPCR), has high similarity to uncharacterized C. elegans F47C12.10 7TM chemoreceptor, srh family F47C12.4 F47C12.4 Member of the C-type lectin family F47C12.5 F47C12.5 Member of the 7-transmembrane chemoreceptor family of G protein-coupled receptors (GPCR), has high similarity to uncharacterized C. elegans F47C12.10 7TM chemoreceptor, srh family F47C12.6 F47C12.6 Protein of unknown function, has low similarity to uncharacterized C. elegans F47C12.8 F47C12.7 F47C12.7 Protein of unknown function, has low similarity to uncharacterized C. elegans F47C12.8 F47C12.8 F47C12.8 Protein of unknown function, has low similarity to uncharacterized C. elegans F47C12.7 F47C8.1 F47C8.1 Member of the reverse transcriptase family, which are RNA-dependent DNA polymerases, has a region of low similarity to a region of LINE retrotransposable element 1 (human LRE1), which reverse transcribes L1 elements reverse transcriptase F47D12.1 F47D12.1 Member of the rhodopsin family of G protein-coupled receptors (GPCR), has low similarity to C. elegans GAR-1, which is a g protein-linked acetylcholine receptor with three alternatively spliced forms G-protein-linked acetylcholine receptor GAR-2 F47D12.3 F47D12.3 Protein containing a K+ channel tetramerization domain, which facilitate assembly of alpha-subunits into functional tetrameric channels F47D12.4 hmg-1.2;son-1;F47D12.4 Member of the HMG (High Mobility Group) Box protein family F47D12.5 F47D12.5 Protein with weak similarity to C. elegans ZYG-11, which is required for zygote formation F47D12.6 F47D12.6 Protein of unknown function F47D12.7 F47D12.7 Protein containing five Kelch motif domains and a BTB (BR-C, ttk and babor) or POZ (Pox virus and zinc finger) domain, has low similarity to C. elegans KEL-1, which is involved in feeding behavior and larval development F47D12.9 F47D12.9 Protein of unknown function F47D2.1 F47D2.1 Protein containing a DUF32 domain of unknown function, has very strong similarity to uncharacterized C. elegans F47D2.7 7TM chemoreceptor, srt family F47D2.10 F47D2.10 Putative paralog of C. elegans F47D2.9 7TM chemoreceptor, srh family F47D2.2 F47D2.2 Member of the reverse transcriptase protein family, which are RNA-dependent DNA polymerases, contains a DUF32 domain of unknown function F47D2.3 F47D2.3 Protein containing a DUF32 domain of unknown function, has high similarity to uncharacterized C. elegans Y45G12C.5 7TM chemoreceptor, srt family F47D2.4 F47D2.4 Protein containing a DUF32 domain of unknown function, has high similarity to uncharacterized C. elegans F47D2.6 7TM chemoreceptor, srt family F47D2.5 F47D2.5 Protein containing a DUF32 domain of unknown function, has strong similarity to uncharacterized C. elegans F47D2.6 7TM chemoreceptor, srt family F47D2.6 F47D2.6 Protein containing a DUF32 domain of unknown function, has strong similarity to uncharacterized C. elegans F47D2.5 7TM chemoreceptor, srt family F47D2.7 F47D2.7 Protein containing a DUF32 domain of unknown function, has very strong similarity to uncharacterized C. elegans F47D2.1 7TM chemoreceptor, srt family F47D2.8 F47D2.8 Protein containing two DUF32 domains of unknown function, has low similarity to uncharacterized C. elegans F40G12.8 7TM chemoreceptor, srt family F47D2.9 F47D2.9 Member of the 7-transmembrane chemoreceptor family of G protein-coupled receptors (GPCR), has strong similarity to uncharacterized C. elegans F47D2.10 7TM chemoreceptor, srh family F47E1.1 F47E1.1 Protein of unknown function, has weak similarity to C. elegans EGAP4.1 F47E1.2 F47E1.2 Protein containing an organic anion transporter polypeptide family N-terminus domain, has weak similarity to organic anion transporting polypeptide 2 (human SLC21A6, which is a sodium-independent organic anion transporter that also transports bilirubin DNA binding protein F/G F47E1.3 F47E1.3 Protein containing four C2H2 type zinc finger domains, which bind nucleic acids, has a region of low similarity to a region of growth factor independent 1 (mouse Gfi1), which is involved in transcriptional regulation and T-cell differentiation C2H2-type zinc fingers F47E1.4 F47E1.4 Putative ortholog of C. elegans F47E1.2 gene product F47F2.1 F47F2.1 Protein with high similarity to protein kinase X-linked (human PRKX), which is a cAMP-dependent protein kinase catalytic subunit involved in signaling in macrophage development, contains two protein kinase domains and two protein kinase C-terminal domains protein kinase F47F2.2 F47F2.2 Protein of unknown function F47F2.3 F47F2.3 Protein containing three uncharacterized DUF139 cysteine repeat domains F47F6.1 F47F6.1 Protein of unknown function F47F6.2 lin-42;F47F6.2 Protein that regulates the switch from L4 larval stage to the adult; shares similarity with PER (period) proteins, that set the period length of circadian and ultradian rhythms F47F6.3 F47F6.3 Protein containing a DUF33 domain of unknown function, has moderate similarity to uncharacterized C. elegans R03H4.6 F47F6.4 F47F6.4 Protein of unknown function F47F6.5 F47F6.5 Member of the calpain family of cysteine proteases, contains a C-type lectin domain, which mediate calcium-dependent carbohydrate recognition, has a region of low similarity to a region of calpain I (mouse Capn1), which is a catalytic mu-calpain subunit proteinase F47F6.8 F47F6.8 Protein of unknown function F47G3.1 F47G3.1 Protein of unknown function that may be anchored to the membrane of a secretory vesicle or the Golgi apparatus F47G3.2 F47G3.2 Member of the anion-transporting ATPase family, which are involved in removal of arsenate and antimonite from the cell, has low similarity to arsenite transporter ATP-binding homolog 1 (human ASNA1), which is an ATPase and putative arsenite transporter E. coli arsenical pump-driving ATPase (ARSA) F47G3.3 F47G3.3 Protein of unknown function F47G4.1 F47G4.1 Protein of unknown function, has low similarity to uncharacterized C. elegans Y71A12B.5 F47G4.2 F47G4.2 Protein with weak similarity to C. elegans ZYG-11, which is required for zygote formation Leucine Rich Repeat (2 copies) F47G4.3 F47G4.3 Member of the glycerol-3-phosphate dehydrogenase, cytoplasmic protein family NAD-dependent glycerol-3-phosphate dehydrogenase F47G4.4 F47G4.4 Protein containing two WD domains (WD-40 repeat), which may mediate protein-protein interactions, has weak similarity to katanin p80 (WD40-containing) subunit B 1 (human KATNB1), which is the regulatory subunit of the microtubule-stimulated ATPase katanin F47G4.4 encodes a paralog of MEI-2 that, like MEI-2, binds MEI-1 in vitro; F47G4.4 might thus be an alternative ligand of MEI-1 in vivo. F47G4.5 F47G4.5 Protein with low similarity to C. elegans MEI-2, which is involved in microtubule disassembly during meiotic spindle formation F47G4.5 encodes a paralog of MEI-2 that, like MEI-2, binds MEI-1 in vitro; F47G4.5 might thus be an alternative ligand of MEI-1 in vivo. F47G4.6 F47G4.6 Protein of unknown function, has weak similarity to C. elegans B0524.D F47G4.7 smd-1;sam-1;samdc;F47G4.7 S-adenosylmethionine decarboxylase F47G4.8 F47G4.8 Protein of unknown function F47G6.1 dyb-1;F47G6.1 Ortholog of human dystrobrevin The dyb-1 gene encodes a homolog of mammalian alpha-dystrobrevin (DTNA; OMIM:601239), mutation of which can lead to left ventricular noncompaction with congenital heart defects. F47G6.2 F47G6.2 Member of the AMP-binding enzyme family, has low similarity to uncharacterized human FLJ20920 F47G6.3 F47G6.3 Protein of unknown function F47G6.4 spe-15;hum-3;F47G6.4 Unconventional myosin VI required for asymmetrically partitioning cellular components during spermatogenesis spe-15 is orthologous to the human gene MYOSIN VI (MYO6; OMIM:600970), which when mutated leads to disease. F47G9.1 F47G9.1 Member of the p24 family of type I membrane proteins, involved in negative regulation of LIN-12 and GLP-1 activity Fugu S31III125 protein F47G9.2 F47G9.2 Member of the 7-transmembrane chemoreceptor family of G protein-coupled receptors (GPCR), has low similarity to C. elegans ODR-10, which is involved in odorant response F47G9.3 F47G9.3 Protein containing two PAN domains, which may mediate protein-protein or protein-carbohydrate interactions, has weak similarity to uncharacterized C. elegans C34G6.6 F47G9.4 F47G9.4 Member of the B-box zinc finger family, contains a C3HC4 type (RING) zinc finger, which may mediate protein-protein interactions Zinc finger, C3HC4 type (RING finger) F47G9.5 F47G9.5 Member of the transposase family, which are required for excising and inserting mobile genetic elements, has very strong similarity to uncharacterized C. elegans C31A11.2 transposase F47G9.6 F47G9.6 Putative ortholog of C. elegans F40H6.5 gene product F47H4.1 F47H4.1 Protein containing three C2H2 type zinc finger domains, which bind nucleic acids, has a region of moderate similarity to a region of C. elegans HAM-2, which is a putative transcription factor required for the migration of hermaphrodite-specific neurons Zinc finger, C2H2 type (2 domains) F47H4.11 F47H4.H;F47H4.11 Protein containing a DUF38 domain of unknown function F47H4.2 F47H4.2 Protein containing three DUF38 domains of unknown function and an F-box domain, which serves as a link between a target protein and a ubiquitin-conjugating enzyme, has high similarity to uncharacterized C. elegans Y6G8.2 This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins; this gene's encoded protein also contains an FTH/DUF38 motif, which may also mediate protein-protein interaction. F47H4.4 F47H4.4 Member of an uncharacterized protein family F47H4.6 F47H4.6 Protein containing a DUF38 domain of unknown function, and an F-box domain, which serve as a link between a target protein and a ubiquitin-conjugating enzyme, has a region of low similarity to C. elegans FOG-2, which is required for germ cell identity This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins; this gene's encoded protein also contains an FTH/DUF38 motif, which may also mediate protein-protein interaction. F47H4.7 F47H4.C;F47H4.7 Protein containing a DUF38 domain of unknown function and an F-box domain, which serve as a link between a target protein and a ubiquitin-conjugating enzyme, has a region of low similarity to C. elegans FOG-2 This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins; this gene's encoded protein also contains an FTH/DUF38 motif, which may also mediate protein-protein interaction. F47H4.8 F47H4.D;F47H4.8 Protein containing a DUF38 domain of unknown function and an F-box domain, which serve as a link between a target protein and a ubiquitin-conjugating enzyme, has moderate similarity to uncharacterized C. elegans C38D9.7 This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins; this gene's encoded protein also contains an FTH/DUF38 motif, which may also mediate protein-protein interaction. F47H4.9 F47H4.E;F47H4.9 Protein containing a DUF38 domain of unknown function and an F-box domain, which serve as a link between a target protein and a ubiquitin-conjugating enzyme, has a region of low similarity to C. elegans FOG-2 This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins; this gene's encoded protein also contains an FTH/DUF38 motif, which may also mediate protein-protein interaction. F47H4.F skr-5;F47H4.10;F47H4.F Member of the Skp1 family, which are required for targeted protein degradation during the cell cycle, has moderate similarity to a region of S. cerevisiae Skp1p, which is a component of the Cbf3 kinetochore and SCF (Skp1p-cullin-F-box) complexes F48A11.1 F48A11.1 Putative paralog of C. elegans T25G3.2, has similarity to chitin synthase chi-2 encodes a putative chitin synthase, most closely related to chitin synthases characterized in arthropods. F48A11.2 F48A11.2 Protein of unknown function F48A11.3 F48A11.3 Protein of unknown function F48A11.4 F48A11.4 Protein of unknown function F48A11.5 F48A11.5 Protein of unknown function, has a region of low similarity to a region of fas associated factor 1 (mouse Faf1), which binds to Fas (mouse Tnfrsf6) and that may have a role in apoptosis and may also be a signal transducing molecule F48A4.7 F58A4.7;F48A4.7 Protein containing two helix-loop-helix DNA-binding domains, which mediate protein dimerization, has a region of low similarity to a region of transcription factor AP4 (human TFAP4), which is a transcriptional coactivator and repressor F48A9.1 F48A9.1 Protein of unknown function F48A9.2 F48A9.2 Protein of unknown function F48A9.3 F48A9.3 Member of the trypsin family of serine proteases peptidase F48B9.1 F48B9.1 Protein of unknown function F48B9.2 F48B9.2 Protein of unknown function F48B9.3 F48B9.3 Protein of unknown function F48B9.4 F48B9.4 Protein of unknown function F48B9.5 F48B9.5 One member of a four protein Pax-like gene family, the Npax family, in C. elegans; the protein contains only the N-terminal PAI subdomain of the Paired domain paired box protein F48B9.7 F48B9.7 Member of the reverse transcriptase protein family, which are RNA-dependent DNA polymerases F48B9.8 F48B9.8 Protein of unknown function F48C1.1 F48C1.1 Member of the glycosyl hydrolase family 38 of alpha-mannosidases, which are involved in carbohydrate metabolism, has low similarity to alpha-mannosidase II (human MAN2A1), which is associated with some cases of congenital dyserythropoietic anemia type II alpha-mannosidase II F48C1.2 F48C1.2 Protein containing an F-box domain, which serve as a link between a target protein and a ubiquitin-conjugating enzyme This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins. F48C1.3 F48C1.3 Protein of unknown function F48C1.4 F48C1.4 Protein of unknown function F48C1.5 F48C1.5 Protein of unknown function F48C1.6 F48C1.6 Protein of unknown function F48C1.7 spe-11;F48C1.7 Paternally supplied protein required for completion of meiosis spe-11 encodes a novel protein that is required for early embryonic development and for regulating the dynamic morphology of sperm pseudopods; although the precise biological role of SPE-11 is not yet known, SPE-11 is one of the few paternally provided proteins known to be essential for embryogenesis, and may constitute a sperm-associated factor required for oocyte activation; SPE-11 is first detected in the nuclei of primary spermatocytes and then remains tightly associated with sperm chromatin until fertilization at which point it appears to be degraded. F48C1.8 F48C1.8 Protein of unknown function, has weak similarity to C. elegans F55A12.6 F48C11.1 gpa-6;F48C11.1 Member of the G protein alpha subunit family guanine nucleotide-binding protein; gpa-6 encodes a member of the G protein alpha subunit family of heterotrimeric GTPases that affects response to water-soluble odorants; it is expressed in AWA amphid neurons, the PHB sensory cell, and (at low levels) in ASI amphid neurons. F48C11.2 F48C11.2 Protein containing a C-type lectin domain, which mediate calcium-dependent carbohydrate recognition F48C11.3 F48C11.3 GFxGF neurotransmitter nlp-3 encodes a neuropeptide-like protein of the GFxGF family with similarity to orcokinins, highly conserved peptides native to crustaceans that enhance hindgut contractions; NLP-3 is expressed in neurons in the head, pharynx, and vulva, and in the intestine; the precise role of NLP-3 in nervous system function and development is not yet clear. F48C5.1 F48C5.1 Protein containing an immunoglobulin (Ig) domain, which may be involved in protein-protein and protein-ligand interactions IG (immunoglobulin) superfamily F48D6.1 taf7.1;F48D6.1 Protein of unknown function, has a region of moderate similarity to TATA box binding protein (TBP)-associated factor RNA polymerase II I 28 (human TAF11), which is a transcriptional coactivator for several nuclear receptors F48D6.2 F48D6.2 Putative ortholog of C. elegans C52B9.5 gene product 7TM chemoreceptor, srv family F48D6.3 nato-3;F48D6.3 Protein containing a helix-loop-helix DNA-binding domain, which mediate protein dimerization, has a region of high similarity to a region of pancreas specific transcription factor 1a (mouse Ptf1a), which is a transcription factor F48D6.4 F48D6.4 Protein of unknown function F48E3.1 gly-12;F48E3.1 UDP-N-acetylglucosamine:alpha-3-D-mannoside beta-1,2-N-acetyl-glucosaminyltransferase I alpha-1,3-mannosyl-glycoprotein beta-1, 2-N-acetylglucosaminyltransferase I F48E3.2 F48E3.2 Member of the sugar (and other) transporter family, has weak similarity to facilitative glucose transporter isoform 5 (rat Slc2a5), which is a glucose transporter that also transports fructose Glucose transporter F48E3.3 F48E3.3;Ce-1 Putative paralog of C. elegans F26H9.8, has strong similarity to Human HUGT1, UDP-glucose-glycoprotein glucosyltransferase killer toxin-resistance protein (S. cerevisiae) F48E3.4 F48E3.4 Protein of unknown function F48E3.6 F48E3.6 Protein of unknown function F48E3.7 acr-22;F48E3.7 Protein containing a neurotransmitter-gated ion-channel ligand binding domain, has low similarity to 5-hydroxytryptamine (serotonin) receptor 3A (human HTR3A), which is a ligand-gated ion channel that mediates a variety of neurophysiological effects Acetycholine receptor; acr-22 encodes a predicted member of the nicotinic acetylcholine receptor nonalpha subunit family with highest similarity to human neuronal acetylcholine receptor alpha-9 subunit. F48E3.8 F46C8.4;F48E3.8 Protein containing 18 EB module domains, has weak similarity to fibrillin-1 (human FBN1), which is an extracellular matrix protein of connective tissue microfibrils that is associated with Marfan Syndrome, Shprintzen-Goldberg syndrome, and ectopia lentis F48E3.9 F48E3.9 Protein of unknown function F48E8.1 F48E8.1 Member of the SCP-like extracellular protein family, has a region of low similarity to testis specific protein 1 (rat Tpx1), which functions as a cell adhesion molecule that mediates interactions between spermatogenic and Sertoli cells The lon-1 gene encodes a protein belonging to the PR-protein superfamily that is a target of DBL-1 (TGF-beta) signaling, and that regulates polyploidization and body length. F48E8.2 F48E8.2 Protein with weak similarity to C. elegans ZK546.14 F48E8.3 F48E8.3 Protein containing four FAD binding domains, has moderate similarity to S. cerevisiae Yel047p, which is a cytoplasmic fumarate reductase involved in succinate and fumarate metabolism fumarate reductase flavoprotein; This gene encodes a protein predicted by Eisenberg and coworkers, with 52% accuracy, to be mitochondrial. F48E8.4 F48E8.4 Protein of unknown function, has weak similarity to human OS-9 in the N-terminus, a protein with amplified expression in sarcomas (Hs.76228 ) F48E8.5 PP2A-A;F48E8.5 Putative A-type regulatory subunit for serine/threonine phosphatase 2A Protein phosphatase 2A; paa-1 encodes a homolog of PR65, the structural subunit of protein phosphatase 2A (PP2A); PAA-1 protein is bound by SMG-5; PAA-1 is required in mass RNAi assays for embryonic viability, fertility, and cuticular integrity. F48E8.6 F48E8.6 Member of the RNB-like family, which may have exonuclease activity, has low similarity to S. pombe Dis3p, which is an essential protein required for anaphase A mitotic events F48E8.7 F48E8.7 Protein containing an F-box domain, which serve as a link between a target and a ubiquitin-conjugating enzyme, has low similarity to human SKP2, which mediates the ubiquitin-dependent degradation of regulatory proteins involved in G1/S phase transition This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins; this gene's encoded protein also contains leucine-rich repeats. F48F5.1 F48F5.1 Member of the protein-tyrosine phosphatase family, which are involved in control of cell growth, proliferation, and differentiation, has a region of low similarity to a region of human PTPN9, which is a non-receptor type protein tyrosine phosphatase Protein-tyrosine phosphatase F48F5.2 F48F5.2 Protein of unknown function F48F5.3 F48F5.3 Protein of unknown function F48F5.4 F48F5.4 G protein-coupled receptor, member of a subfamily with SRD proteins which are expressed in chemosensory neurons, no homolog found in human or D. melanogaster F48F7.1 alg-1;F48F7.1 Piwi-related protein with a role in the production of stRNA (small temporal RNA) lin-4 from its precursor; functionally overlaps with ALG-2 A homolog of rde-1 that is involved in RNA interference and affects developmental timing along with alg-2 and dcr-1 by regulating expression of the lin-4 and let-7 small temporal RNAs. F48F7.2 syn-2;F48F7.2 Member of the syntaxin family of vesicular transport receptors, has low similarity to syntaxin 1A (rat Stx1a), which participates in neuronal intracellular membrane fusion during vesicle docking syntaxin like F48F7.3 F48F7.3 Member of the galactosyltransferase family, has weak similarity to UDP-galactose:beta-N-acetylglucosamine beta-1,3-galactosyltransferase (human B3GALT1), which is specific for beta-linked GlcNAc acceptors and is decreased in some colon adenocarcinomas F48F7.4 F48F7.4 Protein of unknown function The protein product of this gene is predicted to contain a glutamine/asparagine (Q/N)-rich ('prion') domain, by the algorithm of Michelitsch and Weissman (as of the WS77 release of WormBase, i.e., in wormpep77). F48F7.5 F48F7.5 Protein containing two C2H2 type zinc finger domains, which bind nucleic acids, has low similarity to uncharacterized C. elegans ZK899.6 Zinc finger, C2H2 type (2 domains) F48F7.6 F48F7.6 Protein of unknown function F48F7.7 F48F7.7 Member of an uncharacterized protein family F48G7.1 srj-37;F48G7.1 Member of the 7-transmembrane chemoreceptor family of G protein-coupled receptors (GPCR), has high similarity to uncharacterized C. elegans T03D3.14 7TM chemoreceptor, srj family F48G7.10 F48G7.10 Putative paralog of C. elegans R12G8.1, has similarity to phorbol esters/diacyglycerol binding domains F48G7.11 F48G7.11 Protein containing a nuclear hormone receptor C4-type zinc finger domain, which bind DNA and may be involved in regulation of transcription, has low similarity to C. elegans NHR-58, which is involved in embryogenesis and morphogenesis nuclear hormone receptor F48G7.12 F48G7.12 Protein containing a DUF227 domain of unknown function, has strong similarity to uncharacterized C. elegans T16G1.7 F48G7.13 F48G7.13 Protein of unknown function F48G7.2 F48G7.2 Protein of unknown function, has weak similarity to C. elegans C54D10.7 F48G7.3 nhr-83;F48G7.3 Protein containing two nuclear hormone receptor C4-type zinc finger domains, which bind DNA and may be involved in regulation of transcription, has a region of low similarity to C. elegans NHR-58, which is involved in embryogenesis and morphogenesis nuclear hormone receptor F48G7.4 F48G7.4 Protein of unknown function, has weak similarity to C. elegans T27B7.7 F48G7.5 F48G7.5 Protein of unknown function, has strong similarity to uncharacterized C. elegans F48G7.8 F48G7.6 F48G7.6 Protein containing a DUF32 domain of unknown function, has high similarity to uncharacterized C. elegans C50H11.11 7TM chemoreceptor, srt family F48G7.7 F48G7.7 Member of an uncharacterized protein family F48G7.8 F48G7.8 Protein of unknown function, has strong similarity to uncharacterized C. elegans F48G7.5 F48G7.9 F48G7.9 Protein with strong similarity to C. elegans F48G7.10, has similarity to phorbol esters/diacylglycerol binding domains F49A5.2 F49A5.2 Member of the C-type lectin family, has similarity to human C-type mannose receptor MRC1 Lectin C-type domain short and long forms (2 domains) F49A5.3 F49A5.3 Member of the C-type lectin protein family Lectin C-type domain short and long forms F49A5.4 F49A5.4 Member of the C-type lectin protein family Lectin C-type domain short and long forms (2 domains) F49A5.5 F49A5.5 Member of the C-type lectin protein family Lectin C-type domain short and long forms (2 domains) F49A5.6 F49A5.6 Member of the thaumatin family of plant pathogenesis associated (PR) proteins, has high similarity to uncharacterized C. elegans F28D1.3 Thaumatin family F49A5.7 F49A5.7 Member of the C-type lectin protein family Lectin C-type domain short and long forms (2 domains) F49A5.8 F49A5.8 Putative ortholog of C. elegans C41G6.7 gene product 7TM chemoreceptor, srw family F49B2.1 F49B2.1 Protein containing an F-box domain, which serve as a link between a target protein and a ubiquitin-conjugating enzyme, has low similarity to uncharacterized C. elegans Y20C6A.2 This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins; its encoded protein also contains a Pfam-B45 motif of presently unknown function. F49B2.2 F49B2.2 Protein containing an F-box domain, which serve as a link between a target protein and a ubiquitin-conjugating enzyme, has moderate similarity to uncharacterized C. elegans F09C3.5 This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins; its encoded protein also contains a Pfam-B45 motif of presently unknown function. F49B2.3 F49B2.3 Protein of unknown function, has moderate similarity to C. elegans Y116A8B.1 F49B2.4 F49B2.4 Protein containing an F-box domain, which serve as a link between a target protein and a ubiquitin-conjugating enzyme This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins. F49B2.5 kin-22;Cehd-4;F49B2.5 Protein with high similarity to v-src avian sarcoma viral oncogene homolog (human SRC), which is a tyrosine kinase involved in cell proliferation and adhesion, contains protein kinase, Src homology 2 (SH2), and Src homology 3 (SH3) domains Src homology domain 2, Src homology domain 3, protein tyrosine kinase (src subfamily) F49B2.6 F49B2.6 Member of the M1 peptidase family of aminopeptidases F49C12.1 F49C12.1 Protein of unknown function, has high similarity to uncharacterized C. elegans F49C12.3 F49C12.10 F49C12.10 Protein of unknown function F49C12.11 F49C12.11 Protein of unknown function that has strong similarity to S. cerevisiae Ylr262C-Ap F49C12.12 F49C12.12 Protein of unknown function F49C12.13 F49C12.13 Protein of unknown function, has high similarity to uncharacterized lysosomal H+ transporting ATPase (vacuolar proton pump) 9kD (human ATP6H) F49C12.14 F49C12.14 Protein of unknown function, has weak similarity to uncharacterized C. elegans Y34B4A.9 F49C12.15 F49C12.15 Protein of unknown function F49C12.2 F49C12.2 Member of the domain of unknown function DUF13 family, has high similarity to uncharacterized C. elegans F49C12.4 F49C12.3 F49C12.3 Member of an uncharacterized protein family F49C12.4 F49C12.4 Member of the domain of unknown function DUF13 family, has high similarity to uncharacterized C. elegans F49C12.2 F49C12.5 F49C12.5 Protein containing two DUF23 domains of unknown function, has high similarity to uncharacterized C. elegans Y97E10B.1 F49C12.6 F49C12.6 Protein of unknown function, has moderate similarity to uncharacterized C. elegans W02D3.4 F49C12.7 F49C12.7 Protein containing a DUF227 domain of unknown function, has low similarity to uncharacterized C. elegans T16G1.4 F49C12.8 rpn-7;F49C12.8 Putative non-ATPase subunit of 19S proteasome particle, member of the PCI domain protein family rpn-7 is predicted to encode a non-ATPase subunit of the 19S regulatory complex of the proteasome that affects fertility and embryonic viability. F49C12.9 F49C12.9 Protein containing a UBA (ubiquitin associated) or TS-N domain F49C5.1 F49C5.1 Protein of unknown function, has high similarity to uncharacterized C. elegans T21B4.12 7TM receptor, srx family F49C5.2 F49C5.2 Member of the G protein-coupled receptor protein family 7TM receptor, srx family F49C5.3 F49C5.3 Protein of unknown function, has very strong similarity to uncharacterized C. elegans Y48A6B.8 F49C5.4 F49C5.4 Protein containing a protein kinase domain, has moderate similarity to S. pombe Cmk1p, which is a calmodulin-dependent protein kinase serine/threonine kinase (KIN1/SNF1/Nim1 subfamily) F49C5.5 F49C5.5 Protein of unknown function F49C5.6 F49C5.6 Member of the 7-transmembrane chemoreceptor family of G protein-coupled receptors (GPCR), has low similarity to C. elegans ODR-10, which is involved in odorant response F49C5.7 F49C5.7 Protein of unknown function, has high similarity to uncharacterized C. elegans C35A11.3 F49C5.8 F49C5.8 Protein of unknown function, has strong similarity to C. elegans K03H6.3 transposase F49D11.1 F49D11.1 Putative pre-mRNA splicing factor, putative ortholog of human hPrp17 and yeast Cdc40p/Prp17p, member of the WD repeat protein family F49D11.2 F49D11.2 Protein with moderate similarity to C. elegans Y45F10B.12 gene product F49D11.3 F49D11.3 Protein of unknown function, has high similarity to uncharacterized C. elegans F49D11.6 F49D11.4 F49D11.4 Protein with strong similarity to C. elegans Y39A1A.16 gene product F49D11.5 F49D11.5 Member of the reverse transcriptase protein family, which are RNA-dependent DNA polymerases, has high similarity to uncharacterized C. elegans F31A9.6 reverse transcriptase F49D11.6 F49D11.6 Protein of unknown function, has high similarity to uncharacterized C. elegans F49D11.3 F49D11.7 F49D11.7 Protein of unknown function F49D11.8 F49D11.8 Protein containing two calponin homology (CH) domains, which bind actin, has low similarity to a region of calponin 1 (human CNN1), which is a putative actin-binding protein expressed in smooth muscle cells cpn-4 encodes a calponin homolog, most closely related to its paralog CPN-3 in C. elegans; CPN-4 is somewhat more similar to calponins per se (such as CLP1 and CLP2 in humans) than to the to the calponin paralogs transgelin (SM22 alpha) or neuronal protein NP25. F49D11.9 F49D11.9 Protein containing four WD domains (WD-40 repeat), which may mediate protein-protein interactions F49E10.1 F49E10.1 Protein containing two TBC domains, which may be GTPase activators of Rab-like small GTPases, has a region of low similarity to a region of S. cerevisiae Gyp7p, which is a GTPase-activating protein for Ypt7p F49E10.2 F49E10.2 Member of the retinal pigment epithelial membrane protein family, has a region of weak similarity to beta,beta-carotene-9',10'-dioxygenase (mouse B-diox-II), which asymmetrically cleaves provitamin A to form beta-apo-10'-carotenal and beta-ionone F49E10.3 flp-7;F49E10.3 Putative FMRF-amide neurotransmitters flp-7 encodes an MVRFamide-containing peptide that, upon injection into A. suum, produces paralysis and loss of locomotory waveforms, increased body length, and decreased cAMP production. F49E10.4 F49E10.4 Protein of unknown function F49E10.5 F49E10.5 Protein containing two D-isomer specific 2-hydroxyacid dehydrogenase catalytic domains and two D-isomer specific 2-hydroxyacid dehydrogenase NAD binding domains, has a region of high similarity to rat Ctbp1, which is a GTP-binding protein dehydrogenase F49E11.1 F49E11.1 Protein containing three protein kinase domains, has low similarity to S. cerevisiae Yak1p, which is a serine-threonine protein kinase and a negative regulator of cell growth acting in opposition to cAMP-dependent protein kinase A serine/threonine kinase (2 domains) F49E11.10 F49E11.10 Member of the SCP-like extracellular protein family, has low similarity to a region of acidic epididymal glycoprotein (rat Aeg), which plays a role in sperm-egg fusion and may play a role in sperm development testis-specific protein TPX-1 like F49E11.11 F49E11.11 Member of the SCP-like extracellular protein family, has low similarity to a region of acidic epididymal glycoprotein (rat Aeg), which plays a role in sperm-egg fusion and may play a role in sperm development testis-specific protein TPX-1 like F49E11.2 F49E11.2 Protein of unknown function, has weak similarity to C. elegans ZK418.6 adenosine receptor like protein F49E11.3 F49E11.3 Member of the ammonium transporter family of membrane transporters, has weak similarity to S. cerevisiae Mep2p, which is an ammonia permease of low capacity and high affinity ammonium transporter like; a homolog of ammonium transporter. F49E11.4 F49E11.4 Protein of unknown function, has moderate similarity to uncharacterized C. elegans H10D18.4 testis-specific protein TPX-1 like F49E11.5 F49E11.5 Member of the testis-specific protein TPX-1 like protein family, has low similarity to a region of testis specific protein (rat Tpx1), which functions as a cell adhesion molecule that mediates interactions between spermatogenic and Sertoli cells testis-specific protein TPX-1 like F49E11.6 F49E11.6 Member of the SCP-like extracellular protein family, has low similarity to a region of testis specific protein 1 (rat Tpx1), which is a cell adhesion molecule that mediates interactions between spermatogenic and Sertoli cells testis-specific protein TPX-1 like F49E11.7 F49E11.7 Member of the protein phosphatase protein family serine/threonine protein phosphatase F49E11.8 F49E11.8 Protein of unknown function, has moderate similarity to C. elegans C52A10.3 F49E11.9 F49E11.9 Member of the SCP-like extracellular protein family, has low similarity to a region of S. cerevisiae Pry3p, which may have a role in mating efficiency testis-specific protein TPX-1 like F49E12.1 F49E12.1 Member of the animal heme peroxidase family, has low similarity to eosinophil peroxidase (human EPX), which produces reactive oxidants that may be cytotoxic during immune responses and may play a role in eosinophilic inflammatory disorders peroxidase F49E12.10 F49E12.10 Member of the sterol desaturase family, which are involved in cholesterol and plant cuticular wax biosynthesis, has low similarity to C-4 sterol methyl oxidase (S. cerevisiae Erg25p), which is an enzyme of the ergosterol biosynthesis pathway ERG-3 like protein F49E12.2 F49E12.2 Member of the calpain protease protein family F49E12.4 F49E12.4 Member of the ubiquitin-conjugating enzyme (E2) family, has low similarity to ubiquitin-conjugating enzyme E2L 6 (human UBE2L6), which catalyzes the ubiquitination of cellular proteins and marks them for degradation ubiquitin-conjugating enzyme (UBC); ubc-24 encodes a predicted conjugating enzyme (UBCs/E2s) of the ubiquitin-conjugation system. F49E12.5 F49E12.5 Member of C. elegans Sra integral membrane protein family, which contain 6-7 hydrophobic, putative transmembrane, regions, has low similarity to uncharacterized C. elegans SRA-11 F49E12.6 F49E12.6 Protein with an N-terminal region of strong similarity to human, C. elegans, and D. melanogaster E2F transcription factors RBB3 like protein; The F49E12.6 gene encodes a protein with two E2F domains that may be involved in apoptosis. F49E12.7 F49E12.7 Protein with moderate similarity to C. elegans C54G6.3 gene product F49E12.8 F49E12.8 Protein of unknown function F49E12.9 F49E12.9 Member of the sterol desaturase family, which are involved in cholesterol biosynthesis, has low similarity to sterol-C4-methyl oxidase-like (rat Sc4mol), which is a regulator of ecto-5'-nucleotidase that may play a role in neurogenesis ERG-3 like protein F49E2.1 F49E2.1 Member of the MoaC family, which are involved in molybdenum cofactor biosynthesis, contains two MoaA, nifB or pqqE family domains, which may be responsible for binding of an iron-sulfur cluster molybdenum cofactor biosynthesis protein F49E2.2 F49E2.2 Protein containing one Src homology 3 (SH3) domain, which bind proline-rich peptides F49E2.4 F49E2.4 Member of the globin family of oxygen transporters Globin F49E2.5 F49E2.5 Protein with moderate similarity to C. elegans H05O09.1 gene product F49E7.1 F49E7.1 Protein with strong similarity to C. elegans C05D9.6 gene product F49E7.2 F49E7.2 Protein of unknown function F49E8.1 F49E8.1 Protein of unknown function, has weak similarity to uncharacterized S. pombe Spac23h3.03cp F49E8.2 F49E8.2 Protein of unknown function F49E8.3 F49E8.3 Member of the M1 peptidase family of aminopeptidases, has moderate similarity to puromycin-sensitive aminopeptidase (mouse Psa), which is required for fertility and plays roles in prolactin (mouse Prl) secretion and testosterone-mediated signaling F49E8.4 F49E8.4 Protein with high similarity to cytidine deaminase (human CDA), which activity inhibits the growth of granulocyte macrophage colony forming cell, contains a cytidine deaminase zinc-binding domain cytidine deaminase; A functional cytidine deaminase that affects morphology of embryos; it is expressed at all life cycle stages. F49E8.5 dif-1;F49E8.5 Member of the mitochondrial carrier protein family involved in embryonic differentiation; putative ortholog of D. melanogaster colt gene product mitochondrial carrier family; dif-1 encodes a putative mitochondrial solute carrier, orthologous to human SLC25A20 (OMIM:212138, mutated in carnitine-acylcarnitine translocase deficiency) that is required for the maintenance of embryonic tissue differentiation and viability; expressed throughout development and in the intestinal cells and hypodermis of the embryo. F49E8.6 F49E8.6 Protein of unknown function F49E8.7 F49E8.7 Protein of unknown function F49F1.1 F49F1.1 Member of an uncharacterized protein family F49F1.10 F49F1.10 Member of the galectin family, which are lectins that bind beta galactosides, has strong similarity to uncharacterized C. elegans F46A8.4 F49F1.11 F49F1.11 Member of the galactoside-binding lectin protein family F49F1.12 F49F1.12 Protein of unknown function F49F1.3 F49F1.3 Protein of unknown function F49F1.4 F49F1.4 Protein of unknown function F49F1.5 F49F1.5 Member of an uncharacterized protein family F49F1.6 F49F1.6 Protein containing a DUF18 domain of unknown function, has high similarity to uncharacterized C. elegans F49F1.1 F49F1.7 F49F1.7 Protein of unknown function, has high similarity to uncharacterized C. elegans F49F1.6 F49F1.8 F49F1.8 Putative ortholog of C. elegans K03D3.8 gene product F49F1.9 F49F1.9 Protein of unknown function, has high similarity to uncharacterized C. elegans F46A8.8 F49H12.1 F49H12.1 Protein with strong similarity to C. elegans F52F12.4 C2H2-type zinc finger protein F49H12.2 F49H12.2 Protein of unknown function F49H12.3 F49H12.3 Protein with weak similarity to D. melanogaster EG:196F3.2 (Protein of unknown function) F49H12.4 F49H12.4 Protein of unknown function F49H12.5 F49H12.5 Protein with strong similarity to C. elegans Y57A10A.23 F49H12.B F49H12.6;F49H12.B Putative ortholog of D. melanogaster CG3209 F49H6.1 F49H6.1 Member of the C-type lectin family Lectin C-type domain short and long forms F49H6.10 F49H6.10 Protein containing a DUF216 domain of unknown function, has high similarity to uncharacterized C. elegans Y102A5C.33 F49H6.11 F49H6.11 Protein containing a DUF216 domain of unknown function, has high similarity to uncharacterized C. elegans Y102A5C.33 F49H6.12 F49H6.12 Protein of unknown function, has weak similarity to C. elegans F49H6.8; may be anchored to the membrane of a secretory vesicle or the Golgi apparatus F49H6.13 F49H6.13 Protein of unknown function, has high similarity to uncharacterized C. elegans T27C5.8 F49H6.2 F49H6.2 Protein containing a C-type lectin domain, which mediate calcium-dependent carbohydrate recognition, has high similarity to uncharacterized C. elegans F49H6.1 Lectin C-type domain F49H6.3 F49H6.3 Protein of unknown function, has high similarity to uncharacterized C. elegans T27C5.8 F49H6.4 F49H6.4 Member of the 7-transmembrane chemoreceptor family of G protein-coupled receptors (GPCR), has high similarity to uncharacterized C. elegans F21H7.11 F49H6.5 F49H6.5;MOCS1A;MOCS1A-B Protein containing a MoaA, nifB or pqqE family domain, has high similarity to uncharacterized molybdenum cofactor synthesis 1 (human MOCS1), which may catalyze the synthesis of molybdopterin and is linked to molybdenum cofactor deficiency type A The F49H6.5 gene encodes a homolog of the human gene MOCS1A, which when mutated leads to molybdenum cofactor deficiency (OMIM:252150). F49H6.7 F49H6.7 Protein of unknown function, has high similarity to uncharacterized C. elegans Y116F11B.5 7TM chemoreceptor, srw family F49H6.8 F49H6.8 Protein with moderate similarity to C. elegans F49H6.12 gene product F49H6.9 F49H6.9 Protein containing a DUF216 domain of unknown function, has moderate similarity to uncharacterized C. elegans Y102A5C.33 F52A8.1 F52A8.1 Protein of unknown function, has moderate similarity to uncharacterized C. elegans Y41C4A.13 F52A8.2 eat-11;gpb-2;F52A8.2 Beta subunit of G protein; member of the WD repeat protein family guanine nucleotide-binding protein; gpb-2 encodes an ortholog of Gbeta(5), that is dispensable for viability, but required for normal egg-laying, locomotion, and pharyngeal pumping; GBP-2 may regulate the interaction between the GOA-1 and EGL-30 signaling pathways based on genetic analysis; gpb-2 is expressed throughout development in the nervous system and in muscle, and expression is dependent upon expression of both EAT-16 and EGL-10. F52A8.3 F52A8.3 Protein of unknown function F52A8.4 F52A8.4 Member of the globin family of oxygen transporters, has weak similarity to uncharacterized C. elegans F19H6.2 globin like F52A8.5 F52A8.5 Protein with high similarity to glycine cleavage system protein H (human GCSH), which is the H-protein component of the glycine cleavage system that is associated with atypical nonketotic hyperglycinemia, member of the glycine cleavage H-protein family glycine cleavage system H protein like; F52A8.5 is orthologous to the human gene GLYCINE CLEAVAGE SYSTEM PROTEIN H (GCSH; OMIM:238330), which when mutated leads to glycine encephalopathy. F52A8.6 F52A8.6 Protein of unknown function, has a region of moderate similarity to I-kappa-B-interacting Ras-like protein 1 (human KBRAS1), which interacts with PEST domains and decreases the degradation rate of IkappaB alpha (CHUK) and beta (IKBKB) ras-like protein like F52B10.1 nmy-1;F52B10.1 Protein with high similarity to non-muscle myosin heavy chain 9 (human MYH9), contains a myosin N-terminal SH3-like domain, a myosin head domain (motor domain), a coiled-coil myosin heavy chain tail region, and an IQ calmodulin-binding domain myosin; nmy-1 encodes a class II non-muscle myosin heavy chain related to Drosophila zipper, which plays a role in several aspects of embryonic morphogenesis; in C. elegans, NMY-1 is required for embryonic elongation and establishment of normal body morphology; mutations in nmy-1 suppress the hypercontraction phenotype produced by mutations in mel-11, a myosin phosphatase that regulates actomyosin filament contraction; in addition, NMY-1 may partner with MLC-4, myosin light chain 4, during elongation; NMY-1 expression is detected during embryogenesis, particularly at the onset of elongation. F52B11.1 F52B11.1 Protein of unknown function, has a region of weak similarity to a region of CpG binding protein (human CGBP), which binds to unmethylated CpG dinucleotides, functions as a transcriptional activator, and may regulate gene expression within CpG islands F52B11.2 F52B11.2 Protein with high similarity to phosphomannomutase 2 (human PMM2), which participates in synthesis of the GDP-mannose required for protein glycosylation by converting mannose-1-phosphate to mannose-6-phosphate F52B11.2 is orthologous to the human gene PHOSPHOMANNOMUTASE 2 (PMS2; OMIM:601785), which when mutated leads to congenital disorder of glycosylation, type Ia. F52B11.3 F52B11.3 Member of an uncharacterized protein family F52B11.4 F52B11.4 Protein with high similarity to C. elegans SQT-3, which is a collagen, contains two collagen triple helix repeats, which are found in some extracellular proteins, and a nematode cuticle collagen N-terminal domain CUTICLE COLLAGEN 34 F52B11.5 F52B11.5 Protein of unknown function F52B11.6 F52B11.6 Protein of unknown function F52B11.7 F52B11.7 Protein of unknown function, has a region of high similarity to a region of solute carrier family 12 member 2 (human SLC12A2), which is a sodium-potassium-chloride cotransporter that transports chloride ions across secretory epithelia F52B5.1 F52B5.1 Protein with high similarity to sodium-driven chloride-bicarbonate exchanger (mouse Slc4a10), which exchanges extracellular sodium and bicarbonate with intracellular chloride, member of the bicarbonate (HCO3-) exchanger family of membrane transporters anion exchange protein F52B5.2 F52B5.2 Protein containing a protein kinase domain, has low similarity to C. albicans Cdc28p, which is a serine-threonine protein kinase involved in the cell cycle serine/threonine kinase (2 domains) F52B5.3 F52B5.3 Protein containing a helicase conserved C-terminal domain and a R3H domain, which may bind ssDNA, has a region of low similarity to RNA helicase A (mouse Ddx9), which has DNA and RNA helicase activity helicase; The F52B5.3 gene encodes a DEAH helicase orthologous to the Drosophila SpindleE protein. F52B5.5 cep-1;F52B5.5 Similar to human p53 tumor suppressor; involved in germ-line apoptosis, meiosis, and stress resistance pathways cep-1 encodes an ortholog of the human tumor suppressor p53 (OMIM:191170, mutated in Li-Fraumeni syndrome) that promotes DNA damage-induced apoptosis and is required for normal meiotic segregation in the germ line, and affects sensitivity to hypoxia-induced lethality and longevity in response to starvation; CEP-1 is expressed ubiquitously in embryos and in the nucleoli of a subset of pharyngeal cells. F52B5.6 F52B5.6 Member of the ribosomal protein L25 protein family 60S ribosomal protein; rpl-25.2 encodes a large ribosomal subunit L23a protein. F52C12.1 F52C12.1 Protein of unknown function, has low similarity to uncharacterized human TDP1 F52C12.2 F52C12.2 Putative ortholog of C. elegans F52C12.2A gene product F52C12.3 F52C12.3 Protein of unknown function F52C12.4 F52C12.4 Protein containing a DENN (AEX-3) domain and a PPR repeat, has a region of weak similarity to a region of rab6 interacting protein 1 (mouse Rab6ip1), which interacts with the mouse Rab6 small GTP-binding protein with a preference for the GTP-bound form F52C12.5 elt-6;F52C12.5 Protein containing two GATA-type zinc finger domains, has moderate similarity to C. elegans EGL-18, which is required for establishing the identity of hypodermal seam cells F52C6.1 F52C6.1 Protein containing a BTB (BR-C, ttk and babor) or POZ (Pox virus and zinc finger) domain, which are found in some DNA and actin binding proteins, and a meprin and TRAF homology (MATH) domain, has high similarity to uncharacterized C. elegans F40B1.1 F52C6.10 F52C6.10 Member of the BTB/POZ domain protein family F52C6.11 F52C6.11 Protein containing a BTB or POZ domain, which are found in some DNA and actin binding proteins and may mediate protein-protein interactions, and a meprin and TRAF homology (MATH) domain, has high similarity to uncharacterized C. elegans F59H6.9 F52C6.12 F52C6.12 Protein with high similarity to ubiquitin-conjugating enzyme E2D 3 (human UBE2D3), which catalyzes the ubiquitination of cellular proteins and marks them for degradation, member of the ubiquitin-conjugating enzyme (E2) family F52C6.13 F52C6.13 Protein of unknown function F52C6.14 F52C6.14 Protein of unknown function, has moderate similarity to uncharacterized C. elegans Y54G2A.20 F52C6.2 F52C6.2 Protein with strong similarity to C. elegans F52C6.3 gene product F52C6.3 F52C6.3 Member of the ubiquitin family, has low similarity to S. cerevisiae Ubi4p, which is a ubiquitin polyprotein F52C6.4 F52C6.4 Member of the ubiquitin family, has a region of moderate similarity to a region of C. elegans UBQ-1 F52C6.5 F52C6.5 Protein containing three meprin and TRAF homology (MATH) domains, has high similarity to uncharacterized C. elegans C46F9.2 F52C6.6 F52C6.6 Protein containing a meprin and TRAF homology (MATH) domain F52C6.7 F52C6.7 Protein containing a BTB (BR-C, ttk and babor) or POZ (Pox virus and zinc finger) domain, which are found in some DNA and actin binding proteins, and a meprin and TRAF homology (MATH) domain, has high similarity to C. elegans F40B1.1 F52C6.8 F52C6.8 Member of the BTB/POZ domain protein family F52C6.9 F52C6.9 Protein containing two BTB or POZ domains, which are found in some DNA and actin binding proteins and may mediate protein-protein interactions, and three meprin and TRAF homology (MATH) domains, has high similarity to uncharacterized C. elegans F59H6.11 F52C9.1 F52C9.1 Protein containing four WD domains (WD-40 repeat), which may mediate protein-protein interactions F52C9.2 F52C9.2 Protein with weak similarity to C. elegans VT23B5.2 (Putative acetic acid export pump, putative ortholog of S. cerevisiae BPH1 gene product [probable acetic acid export pump]) cell division control protein F52C9.3 F52C9.3 Protein of unknown function, has weak similarity to C. elegans VT23B5.2, a putative acetic acid export pump cell division control protein F52C9.5 F52C9.5 Protein of unknown function, has weak similarity to C. elegans T26C5.2 F52C9.6 F52C9.6 Member of the reverse transcriptase protein family, which are RNA-dependent DNA polymerases, has strong similarity to uncharacterized C. elegans B0302.3 F52C9.7 F52C9.7 Protein of unknown function F52C9.8 F52C9.8 Protein with weak similarity to S. cerevisiae SIR4 (Coiled-coil protein involved in maintenance of silencing of HMR, HML, and telomeres) F52D1.1 F52D1.1 Member of the glycosyl hydrolases family 31, which are involved in carbohydrate metabolism, has moderate similarity to alpha glucosidase II (mouse G2an), which plays roles in N-glycan processing and glycoprotein folding and maturation acid alpha-glucosidase F52D1.2 F52D1.2 Protein of unknown function F52D1.3 F52D1.3 Protein with weak similarity to C. elegans hmp-1 (Alpha-catenin) The protein product of this gene is predicted to contain a glutamine/asparagine (Q/N)-rich ('prion') domain, by the algorithm of Michelitsch and Weissman (as of the WS77 release of WormBase, i.e., in wormpep77). F52D10.1 F52D10.1 Member of the bicarbonate (HCO3-) exchanger family of membrane transporters, which may be anion exchange or cotransporter proteins, has weak similarity to a region of sodium bicarbonate cotransporter (human SLC4A4) anion exchange protein; The F52D10.1 gene encodes a protein that is homologous to the Arabidopsis and Saccharomyces boron exporters, BOR1 and YNL275w, and similar to the to the human BOR1/YNL275w ortholog, BTS1; like BOR1 and YNL275w, F52D10.1 protein might act to export borate ions. F52D10.2 F52D10.2 Protein of unknown function F52D10.3 ftt-2;F52D10.3 Protein with high similarity to 14-3-3 zeta (human YWHAZ), which is a protein kinase C inhibitor that activates inositol polyphosphate 5-phosphatase and may be associated with Alzheimer's disease, member of the 14-3-3 protein family 14-3-3 protein F52D10.4 F52D10.4 Protein with moderate similarity to C. elegans Y75B7AL.1 gene product F52D10.5 sto-3;F52D10.5 Member of the stomatin protein family erythrocyte band 7 protein F52D10.6 F52D10.6 Protein containing two pleckstrin homology (PH) domains, which mediate protein-protein and protein-lipid interactions, has low similarity to uncharacterized mouse AW228844 PH (pleckstrin homology) domain F52D2.1 F52D2.1 Protein containing an F-box domain, which serve as a link between a target protein and a ubiquitin-conjugating enzyme, and a DUF38 domain, has a region of weak similarity to C. elegans FOG-2, which is required for the sexual identity of germ cells This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins; this gene's encoded protein also contains an FTH/DUF38 motif, which may also mediate protein-protein interaction. F52D2.10 F52D2.10 Protein of unknown function, has weak similarity to C. elegans ZC47.6 This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins; this gene's encoded protein also contains an FTH/DUF38 motif, which may also mediate protein-protein interaction. F52D2.4 F52D2.4 Protein of unknown function, putative paralog of C. elegans C36C9.1 M. musculus T-cell activation protein TCA3; gei-12 encodes a novel protein that affects embryonic viability and development of the hypodermis; interacts with GEX-3 in yeast two-hybrid assays, and is expressed in all somatic cells. F52D2.5 F52D2.5 Protein of unknown function F52D2.6 F52D2.6 Putative paralog of C. elegans C36C9.1 gene product F52D2.7 F52D2.7 Protein of unknown function, has strong similarity to C. elegans T26H2.6 F52D2.8 F52D2.8 Protein of unknown function, putative paralog of C. elegans C39B5.9 This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins; this gene's encoded protein also contains an FTH/DUF38 motif, which may also mediate protein-protein interaction. F52D2.9 F52D2.9 Putative ortholog of C. elegans T26H2.6 gene product 7TM chemoreceptor, str family F52E1.1 pos-1;F52E1.1 Cytoplasmic zinc-finger protein involved in regulation of early morphogenesis zinc-finger protein F52E1.10 F52E1.10 Protein of unknown function, has high similarity to uncharacterized C. elegans T14F9.1 ATPase F52E1.12 F52E1.12 Protein of unknown function, has moderate similarity to C. elegans R05F9.4 F52E1.13 F52E1.13 Protein containing two GRAM domains, which are found in putative membrane-associated proteins, contains two LysM domains, which may bind peptidoglycans, has low similarity to uncharacterized nucleolar protein C7 (mouse Oxr1) F52E1.2 F52E1.2 Protein containing a C-type lectin domain, which mediate calcium-dependent carbohydrate recognition, has a region of moderate similarity to a region of pancreatic group I phospholipase A2 receptor (mouse Pla2g1br), which is involved in the immune response F52E1.3 F52E1.3 Protein of unknown function F52E1.4 gcy-7;F52E1.4 Putative guanylyl cyclase expressed in the ASEL neuron guanylate cyclase F52E1.5 F52E1.5 Protein of unknown function F52E1.6 F52E1.6 Protein of unknown function, has weak similarity to C. elegans R06C7.4 F52E1.8 F52E1.8 Member of the histidine acid phosphatase family, which hydrolyze phosphate esters at low pH, has low similarity to rat Acp2, which is a tartrate-inhibitable lysosomal acid phosphatase lysosomal acid phosphatase F52E1.9 F52E1.9 Protein with weak similarity to C. elegans Y71H2AM.2 gene product F52E10.1 sdc-1;egl-16;F52E10.1 Member of the zinc finger, C2H2 type protein family and involved in C. elegans sex determination and dosage compensation Zinc finger, C2H2 type (3 domains); sdc-1 encodes a zinc-finger protein of the C2H2-type that affects egg laying and vulval development, and hermaphrodite sex determination; expressed at highest levels in embryos and in adults. F52E10.2 F52E10.2 Protein of unknown function F52E10.3 F52E10.3 Protein of unknown function F52E10.4 F52E10.4 Protein of unknown function F52E10.5 ifa-3;Cel-IF-A3;F52E10.5 Member of the intermediate filament family, which are components of the cytoskeleton and nuclear envelope, contains an intermediate filament tail domain, has high similarity to uncharacterized C. elegans IFA-2 intermediate filament protein; ifa-3 encodes an essential intermediate filament protein that is coexpressed with the essential IF protein IFB-1; IFA-3 is required for survival past early larval stages, correct positioning of excretory canals and body muscles, attachment of cuticle to hypodermis, and locomotion; IFA-3 forms heteropolymeric intermediate filaments in vitro with an equimolar mixture of IFB-1; IFA-3 is expressed in embryonic and larval, but not adult, hypodermis. F52E4.1 F52E4.1 Protein with high similarity to propionyl Coenzyme A carboxylase (propanoyl-CoA:carbon-dioxide ligase (ADP-forming)) beta polypeptide (human PCCB), which degrades branched-chain amino acids and fatty acids, contains two carboxyl transferase domains propionyl-CoA carboxylase beta; F52E4.1 is orthologous to the human gene PROPIONYL-CoA CARBOXYLASE, BETA SUBUNIT (PCCB; OMIM:232050), which when mutated leads to propionicacidemia; F52E4.1 protein is predicted to be mitochondrial. F52E4.4 F52E4.4 Member of the ion transport family, which include calcium, sodium, and potassium channels, has a region of weak similarity to a region of potassium channel subfamily K member 10 (human KCNK10) F52E4.5 F52E4.5 Protein of unknown function F52E4.6 wrt-2;F52E4.6 Protein of unknown function, member of the hedgehog-like protein family wrt-2 encodes a (potentially secreted) protein, expressed in seam cells and hypodermal syncytia, with similarity to the carboxy-terminal autoprocessing domain of Drosophila hedgehog; WRT-2 also contains a glutamine/asparagine-rich domain. F52E4.7 F52E4.7 Protein of unknown function, has low similarity to uncharacterized human SEC3 F52E4.8 F52E4.8 Putative ortholog of C. elegans F32E4.8 gene product F52F10.1 F52F10.1 Protein of unknown function, has high similarity to uncharacterized C. elegans Y66H1A.1 F52F10.2 F52F10.2 Protein of unknown function, has moderate similarity to uncharacterized C. elegans C25E10.3 F52F10.3 F52F10.3 Member of the uncharacterized protein family UPF0063, has high similarity to uncharacterized C. elegans F52F10.4 F52F10.4 F52F10.4 Member of the uncharacterized protein family UPF0063, has high similarity to uncharacterized C. elegans F09B9.1 F52F10.5 F52F10.5 Protein of unknown function, has low similarity to uncharacterized C. elegans Y97E10B.4 7TM chemoreceptor, srsx family F52F10.6 F52F10.6 Protein of unknown function F52F12.1 oct-1;oct1;F52F12.1 Organic cation membrane transporter with broad substrate specificity; member of the major facilitator superfamily transporter; oct-1 encodes a organic cation transporter predicted to contain twelve transmembrane domains; OCT-1 induces the transport of the prototypical organic cation tetraethylammonium when expressed in mammalian cells, and has broad substrate specificity; OCT-1 is orthologous to human OCTN2 (OMIM:603377, mutated in primary carnitine deficiency). F52F12.2 F52F12.2 Protein containing two collagen triple helix repeats, which are found in some extracellular proteins, and a nematode cuticle collagen N-terminal domain, has moderate similarity to C. elegans DPY-7, which it a cuticle collagen collagen F52F12.3 mom-4;F52F12.3 Serine/threonine protein kinase with similarity to human transforming growth factor beta-activated kinase and D. melanogaster fibroblast growth factor receptor protein kinase tyrosine-protein kinase F52F12.4 F52F12.4 Protein containing five C2H2 type zinc finger domains, which bind nucleic acids, has low similarity to a region of zinc finger protein 234 (human ZNF234), which is a transcriptional corepressor that may play a role in developmental processes Zinc finger, C2H2 type (4 domains) F52F12.5 F52F12.5 Protein of unknown function F52F12.6 F52F12.6 Protein containing two C2HC-type zinc finger domains, which are involved in DNA binding, has a region of low similarity to a region of myelin transcription factor 1 (human MYT1), which is a transcriptional activator and protein serine-threonine kinase C2HC type zinc finger protein F52F12.7 F52F12.7 Protein containing a START (Steroidogenic Acute Regulatory protein) domain, has low similarity to a region of steroidogenic acute regulatory protein (human STAR), which acts in conversion of cholesterol into pregnenolone and lipoid adrenal hyperplasia steroidogenic acute regulatory protein like; F52F12.7 is orthologous to the human gene STEROIDOGENIC ACUTE REGULATORY PROTEIN (STAR; OMIM:600617), which when mutated leads to disease. F52G2.1 F52G2.1 Putative pyrophosphatase with similarity to S. cerevisiae DCP2, may be required for mRNA decapping Bacterial mutT protein; The ndx-5 gene encodes a NUDIX hydrolase. F52G2.2 F52G2.2 Protein with strong similarity to C. elegans F52G2.3 gene product F52G2.3 F52G2.3 Protein with strong similarity to C. elegans K04G11.3 gene product F52G3.1 F52G3.1 Putative ortholog of C. elegans F52G3.2 gene product F52G3.3 F52G3.3 Protein of unknown function, has moderate similarity to C. elegans F59H6.I F52G3.4 F52G3.4 Protein with moderate similarity to C. elegans F33H12.6 gene product F52G3.5 F52G3.5 Protein with moderate similarity to C. elegans ZK218.3 gene product F52H2.1 F52H2.1 Protein of unknown function F52H2.2 F52H2.2 Member of the amino acid permease family, has strong similarity to human cationic amino acid transporters, has moderate similarity to yeast methionine transporters amino acid permease F52H2.3 F52H2.3 Protein of unknown function F52H2.4 F52H2.4 Member of the sodium:solute symporter family of membrane transporters, has low similarity to sodium-dependent multivitamin transporter (rat Slc5a6), which mediates the electrogenic uptake of pantothenate, biotin, and lipoate by cells F52H2.5 F52H2.5 Protein of unknown function F52H2.6 F52H2.6 Protein containing a FAD-binding domain, has high similarity to uncharacterized human DHCR24 F52H2.6 is orthologous to the human gene 3BETA-HYDROXYSTEROL DELTA 24 REDUCTASE (DHCR24; OMIM:606418), which when mutated leads to disease. F52H2.7 F52H2.7 Protein containing a C2 domain, which may be involved in calcium-dependent phospholipid binding F52H3.1 let-268;F52H3.1 Putative lysine hydroxylase procollagen-lysine,2-oxoglutarate 5-dioxygenase precusor; let-268 encodes a procollagen lysyl hydroxylase that processes type IV collagen, a collagen secreted and incorporated into the basement membrane during embryogenesis (and encoded partly by emb-9); LET-268 activity is essential for type IV collagen processing and secretion and for the stability, but not the formation of, the basement membrane that provides mechanical support to body wall muscle once contraction begins; LET-268 also appears to be required for pharyngeal muscle contraction. F52H3.2 F52H3.2 Member of the glucose inhibited division protein A protein family glucose inhibited division protein; This gene encodes a protein predicted by Eisenberg and coworkers, with 68% accuracy, to be mitochondrial. F52H3.3 F52H3.3 Member of the BTB/POZ domain protein family BTB (also known as BR-C/Ttk) domain. F52H3.4 F52H3.4 Protein with weak similarity to C. elegans Y57A10A.A gene product F52H3.5 F52H3.5 Protein containing three TPR (tetratrico peptide repeat) domains, which may mediate protein-protein interactions F52H3.6 F52H3.6 PP1-type serine/threonine protein phosphatase serine/threonine specific protein phosphatase F52H3.7 lec-2;F52H3.7 Member of the galectin family, has a region of high similarity to galectin (C. elegans LEC-1), which is a galactoside-binding lectin galactoside-binding lectin; lec-2 encodes a 'tandem repeat' type galectin (beta-galactosyl-binding lectin) containing two, tandemly arranged carbohydrate recognition domains; by homology, LEC-2 may play roles in cell adhesion and aggregation, proliferation, or programmed cell death, but as loss of lec-2 activity via large-scale RNAi screens does not result in obvious abnormalities, the precise role of LEC-2 in C. elegans development and/or behavior is not yet known. F53A10.1 F53A10.1 Protein of unknown function F53A10.2 F53A10.2 Putative ortholog of D. melanogaster Rapgap1 (Protein of unknown function) F53A10.2 encodes a Rap1GAP homolog; a region of F53A10.2 encompassing one GoLoco motif specifically binds GOA-1 in yeast two-hybrid assays, and also binds itself; F53A10.2 is expressed in hypodermal seam cells, various neurons, and intestinal cells; F53A10.2 has no obvious function or phenotype in RNAi assays, whether in a normal background or in goa-1(-) or goa-1(gf) mutant backgrounds. F53A2.1 F53A2.1 Protein of unknown function, has a region of low similarity to C. elegans PHA-1, which is involved in pharyngeal development F53A2.2 F53A2.2 Protein of unknown function F53A2.3 F53A2.3 Protein with strong similarity to C. elegans K02E7.2 gene product F53A2.4 nud-1;F53A2.4 Protein with high similarity to nuclear distribution gene C homolog (Aspergillus) (rat Nudc), which interacts with Lis1 (rat Pafah1b1) and plays a role in the regulation of cell growth nud-1 encodes the C. elegans ortholog of the Aspergillus nidulans nudC, which mediates nuclear migration along Aspergillus hyphae. F53A2.5 dro-1;F53A2.5 Member of the eukaryotic histone-like transcription factor (CBF or NF-Y) and archaeal histone family, has moderate similarity to down-regulator of transcription 1 (human DR1), which is a TATA-box-binding protein that acts as a transcriptional repressor Archael histone like F53A2.6 ife-1;F53A2.6 Translation initiation factor eIF4E, binds to the mRNA cap structure; required for spermatogenesis EUKARYOTIC TRANSLATION INITIATION FACTOR 4E (EIF-4E) (EIF4E) (MRNA CAP-BINDING PROTEIN) (EIF-4F 25 KD SUBUNIT); The ife-1 gene encodes one of five C. elegans homologs of the mRNA cap-binding protein eIF4E; it is specifically required for spermatogenesis, and is expressed in P granules. F53A2.7 F53A2.7 Protein containing thiolase N-terminal and C-terminal domains, has moderate similarity to acetyl-coenzyme A acetyltransferase 2 (cytosolic acetoacetyl coenzyme A thiolase, human ACAT2), which is a liver enzyme that functions in acyl-CoA metabolism Thiolases F53A2.8 F53A2.8 Putative ortholog of H. sapiens MTMR6 (myotubularin related protein 6) FYVE zinc finger F53A2.9 F53A2.9 Protein of unknown function F53A3.1 F53A3.1 Protein of unknown function F53A3.2 F53A3.2 Member of the impB, mucB or samB family, which are involved in UV protection, has moderate similarity to a region of DNA polymerase eta (human POLH), which is a low fidelity and low processivity DNA polymerase The F53A3.2 gene encodes an ortholog of the human gene XERODERMA PIGMENTOSUM VARIANT RAD30 (POLH; OMIM:603968), which when mutated leads to xeroderma pigmentosum (OMIM:278750). F53A3.3 F53A3.3 Member of the ribosomal protein S22 protein family 40S ribosomal protein; rps-22 encodes a small ribosomal subunit S15a protein. F53A3.4 F53A3.4 Protein of unknown function The protein product of this gene is predicted to contain a glutamine/asparagine (Q/N)-rich ('prion') domain, by the algorithm of Michelitsch and Weissman (as of the WS77 release of WormBase, i.e., in wormpep77). F53A3.6 F53A3.6 Protein of unknown function F53A3.7 F53A3.7 Protein with weak similarity to D. melanogaster CG12379 (CG12379 gene product) F53A9.1 F53A9.1 Protein of unknown function F53A9.10 F53A9.10 Protein with high similarity to troponin T (C. elegans MUP-2), whic is involved in epidermal differentiation, member of the troponin family, which regulate calcium-induced muscle contraction F53A9.2 F53A9.2 Protein of unknown function F53A9.3 F53A9.3 Protein of unknown function F53A9.4 F53A9.4 Protein of unknown function F53A9.5 F53A9.5 Member of the rhodopsin family of G protein-coupled receptors (GPCR) G-protein coupled receptor F53A9.6 F53A9.6 Protein of unknown function F53A9.7 F53A9.7 Protein of unknown function F53A9.8 F53A9.8 Protein of unknown function F53A9.9 F53A9.9 Protein of unknown function F53B1.2 F53B1.2 Protein containing a SAM (sterile alpha motif) domain, which may mediate protein-protein interactions F53B1.3 F53B1.3 Protein of unknown function F53B1.4 F53B1.4 Member of the NAD-dependent epimerase or dehydratase family, which catalyze reactions involving nucleotide sugar substrates, has low similarity to UDP-glucuronate decarboxylase (C. neoformans Uxs1_D) thymidine diphosphoglucose 4,6-dehydratase F53B1.5 F53B1.5 Protein of unknown function, has weak similarity to C. elegans C03F11.2 F53B1.6 F53B1.6 Protein of unknown function F53B1.7 gpa-5;F53B1.7 Member of the G protein alpha subunit family guaninie nucleotide-binding protein; gpa-5 encodes a member of the G protein alpha subunit family of heterotrimeric GTPases; it is expressed in AWA, with faint expression in ASI. F53B1.8 F53B1.8 Protein containing organic anion transporter polypeptide (OATP) family N-terminus and C-terminus domains, has low similarity to solute carrier family 21 member 12 (human SLC21A12), which transports thyroid hormone by a Na+ independent process zinc-finger DNA-binding protein F53B2.1 F53B2.1 Putative ortholog of C. elegans R11A8.2 gene product F53B2.2 F53B2.2 Member of the tetraspanin family, which contain an N-terminal transmembrane domain that is a signal sequence and membrane anchor, has low similarity to transmembrane 4 superfamily member 2 (human TM4SF2), which is a putative tumor antigen tetraspanin F53B2.3 F53B2.3 Protein of unknown function, has weak similarity to C. elegans F14H8.2 F53B2.4 F53B2.4 Protein containing a DUF215 domain of unknown function, has high similarity to uncharacterized C. elegans Y45F10B.5 F53B2.5 F53B2.5 Protein containing four armadillo or beta-catenin repeats, which mediate interactions with diverse binding partners, has low similarity to a region of C. elegans IMA-3, which is important in germ line and other development Armadillo/beta-catenin-like repeats (2 domains) F53B2.6 F53B2.6 Protein of unknown function ham-1 encodes a novel protein with a winged helix DNA-binding motif; ham-1 is required for the asymmetric divisions of several neuroblasts in the developing embryo and may influence their spindle position; ham-1 mutations also exhibit HSN motor neuron migration defects; HAM-1 interacts with itself in a yeast two-hybrid screen and observations suggest that its multimerization is required for its proper localization; HAM-1 is cytoplasmic and is asymmetrically distributed to the posterior of the HSNPHB neuroblast. F53B2.8 F53B2.8 Protein of unknown function F53B3.1 F53B3.1 Protein containing six C2H2 type zinc finger domains, which bind nucleic acids, has a region of low similarity to a region of zinc finger protein 145 (human ZNF145), which is a transcriptional repressor that interacts with the histone deacetylase complex F53B3.2 F53B3.2 Member of the type 3 O-methyltransferase family F53B3.3 F53B3.3 Protein of unknown function F53B3.5 F53B3.5 Protein of unknown function F53B3.5 encodes a claudin homolog that may regulate ion channels; F53B3.5 is distantly similar to mammalian voltage-dependent calcium channel gamma subunits that are known or suspected to prevent epilepsy in vivo (e.g., stargazin; MGI:1316660); F53B3.5 has no obvious function in mass RNAi assays; claudins are integral membrane proteins with four transmembrane sequences that are found in mammalian tight junctions (TJs), induce TJs when transgenically expressed in cells normally lacking them, and can mediate the specific conductance of of specific ions (e.g., magnesium or calcium) through TJs while blocking the flow of water. F53B3.6 F53B3.6 Putative ortholog of C. elegans F23B3.6 gene product zinc finger protein F53B6.1 F53B6.1 Member of the tetraspanin family, which contain an N-terminal transmembrane domain that is a signal sequence and membrane anchor, has weak similarity to transmembrane 4 superfamily member 7 (novel antigen-2, human TM4SF7), which associates with integrins tetraspanin F53B6.2 F53B6.2 Protein containing an immunoglobulin (Ig) domain, which may be involved in protein-protein and protein-ligand interactions, has weak similarity to a region of C. elegans GON-1, which is a metalloprotease required for gonad morphogenesis thrombospondin like F53B6.4 F53B6.4 Protein containing a major sperm protein (MSP) domain, which are involved in sperm motility, has moderate similarity to uncharacterized C. elegans F21H7.5 F53B6.5 F53B6.5 Protein of unknown function, has a region of high similarity to a region of methionine aminopeptidase 2 (human METAP2), which is a positive regulator of translation that inhibits apoptosis and may be used as an anticancer therapy initiation factor associated protein F53B6.6 F53B6.6 Protein of unknown function, has a region of moderate similarity to a region of C. elegans CUT-1, which is a cuticulin component cuticulin F53B6.7 F53B6.7 Protein of unknown function, has weak similarity to C. elegans F09C12.2, a serine/threonine protein kinase of the MAP kinase subfamily F53B6.8 F53B6.8 Protein of unknown function F53B7.2 F53B7.2 Member of the rhodopsin family of G protein-coupled receptors (GPCR) G-protein coupled receptor; F53B7.2 encodes a homolog of the functionally active Fmrf Receptor (FR; CG2114) of D. melanogaster; it is thus possible that F53B7.2 is a receptor for one of the FMRF-like neurotransmitters in C. elegans (e.g., FLP-1 through FLP-12). F53B7.3 F53B7.3 Protein with weak similarity to S. cerevisiae Isy1p, which is an mRNA splicing factor that is a component of the S. cerevisiae Prp19p -associated complex and the spliceosome F53B7.4 F53B7.4 Protein of unknown function F53B7.5 F53B7.5 Protein containing 18 C. elegans C-terminal C6 domains and a type 1 thrombospondin domain, has a region of low similarity to a region of trans-golgi network protein 2 (human TGOLN2), which is predicted to be involved in Golgi to plasma membrane transport Thrombospondin type 1 domain F53B8.1 F53B8.1 Protein of unknown function F53C11.1 F53C11.1 Protein of unknown function, has low similarity to uncharacterized C. elegans F35E12.6 F53C11.2 F53C11.2 Member of the uncharacterized protein family UPF0063, has moderate similarity to uncharacterized C. elegans C31A11.1 F53C11.3 F53C11.3 Putative peroxisomal Delta(2),Delta(4)-dienoyl-CoA reductase 2,4-dienoyl-CoA reductase; This gene encodes a protein predicted by Eisenberg and coworkers, with 68% accuracy, to be mitochondrial. F53C11.4 F53C11.4 Protein of unknown function F53C11.5 F53C11.5 Protein of unknown function F53C11.6 twk-10;F53C11.6 Member of the ion transport family, contains a fibronectin type III domain, which are involved in cell surface binding, has weak similarity to potassium channel subfamily K member 2 (mouse Kcnk2), which is activated by membrane stretch and arachidonate potassium channel protein like F53C11.7 F53C11.7 Protein containing four WD domains (WD-40 repeat), which may mediate protein-protein interactions, has high similarity to uncharacterized human HAN11, which may be part of a conserved signal transduction pathway Yeast hypothetical protein YPL247C like F53C11.8 F53C11.8 Protein containing three WD domains (WD-40 repeat), which may mediate protein-protein interactions, has high similarity to uncharacterized human HAN11, which may be part of a conserved signal transduction pathway Yeast hypothetical protein YPL247C like F53C3.1 F53C3.1 Protein containing a protein kinase domain, has low similarity to casein kinase 1 delta (human CSNK1D), which is a serine/threonine protein kinase involved in DNA repair and found in neurofibrillary tangles of some neurodegenerative diseases protein kinase F53C3.11 F53C3.11 Protein with low similarity to C. elegans PHA-1, which is involved in pharyngeal development F53C3.12 F53C3.12 Member of the retinal pigment epithelial membrane protein family, has low similarity to beta-carotene 15, 15'-dioxygenase (mouse Bcdo), which catalyzes the oxidative cleavage and conversion of beta-carotene to retinal F53C3.13 F53C3.13 Phosphatidic acid phosphatase phosphatidic acid phosphatase F53C3.2 F53C3.2 Protein containing an F-box domain, which serve as a link between a target protein and a ubiquitin-conjugating enzyme, has low similarity to uncharacterized C. elegans F08D12.8 This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins. F53C3.3 F53C3.3 Protein containing a CX module domain, has high similarity to uncharacterized C. elegans F53C3.6 F53C3.4 F53C3.4 Protein containing a CX module domain, has high similarity to uncharacterized C. elegans F53C3.5 F53C3.5 F53C3.5 Protein containing a CX module domain, has high similarity to uncharacterized C. elegans F53C3.4 F53C3.6 F53C3.6 Protein containing two CX module domains, has high similarity to uncharacterized C. elegans F53C3.3 F53C3.7 F53C3.7 Protein of unknown function F53C3.8 F53C3.8 Protein of unknown function F53C3.9 F53C3.9 Member of the reverse transcriptase protein family, which are RNA-dependent DNA polymerases, has strong similarity to uncharacterized C. elegans F40F12.2 F53E10.1 F53E10.1 Protein of unknown function, has strong similarity to uncharacterized C. elegans F22B8.7 F53E10.2 acr-17;F53E10.2 Protein containing a neurotransmitter-gated ion-channel ligand binding domain, has low similarity to C. elegans DEG-3, which is a subunit of the nicotinic acetylcholine receptor and that is associated with neuronal degeneration acetylcholine receptor protein; an ortholog of alpha subunit of nicotinic acetylcholine receptor (nAChR). F53E10.3 F53E10.3 Protein of unknown function F53E10.4 F53E10.4 Protein of unknown function F53E10.5 F53E10.5 Protein with moderate similarity to C. elegans R03D7.2 gene product F53E10.6 F53E10.6 Protein of unknown function F53E2.1 F53E2.A;F53E2.1 Protein with weak similarity to H. sapiens Hs.106346 (Homo sapiens mRNA for RanBPM, complete cds) F53F1.1 F53F1.1 Protein of unknown function, has high similarity to a region of C. elegans CUT-1, which is a cuticulin component cuticlin F53F1.10 F53F1.10 Protein of unknown function, has high similarity to uncharacterized C. elegans F53F1.11 7TM chemoreceptor (srd-family) F53F1.11 F53F1.11 Member of the 7-transmembrane chemoreceptor family of G protein-coupled receptors (GPCR), has strong similarity to uncharacterized C. elegans Y38A10A.1 7TM chemoreceptor (srd-family) F53F1.2 F53F1.2 Member of the aldo-keto reductase family, which include some related monomeric NADPH-dependent oxidoreductases, has moderate similarity to aldehyde reductase (rat Akr1a1), which reduces carbonyl-containing substrates in a NADPH-dependent manner aldehyde reductase F53F1.3 F53F1.3 Member of the aldo-keto reductase family, which include some related monomeric NADPH-dependent oxidoreductases, has moderate similarity to aldo keto reductase family 1 member C2 (dihydrodiol dehydrogenase, human AKR1C2), which functions in bile transport aldehyde reductase F53F1.4 F53F1.4 Protein of unknown function cuticlin F53F1.5 cut-2;vmp-2;F53F1.5 Cuticulin component cuticlin F53F1.6 F53F1.6 Protein of unknown function F53F1.7 F53F1.7 Protein of unknown function, has high similarity to uncharacterized C. elegans F53F1.9 G-protein coupled receptor, srv family F53F1.8 F53F1.8 Protein of unknown function, has high similarity to uncharacterized C. elegans F53F1.9 G-protein coupled receptor, srv family F53F1.9 F53F1.9 Protein of unknown function, has high similarity to uncharacterized C. elegans F53F1.8 G-protein coupled receptor, srv family F53F10.1 F53F10.1 Protein of unknown function F53F10.2 F53F10.2 Protein containing pyridoxal-dependent decarboxylase pyridoxal binding and pyridoxal-dependent decarboxylase C-terminal sheet domains, has low similarity to ornithine decarboxylase (mouse Odc), which catalyzes decarboxylation of ornithine into putrescine decarbaxylase F53F10.3 F53F10.3 Protein of unknown function, has high similarity to uncharacterized human DKFZP564B167 F53F10.4 F53F10.4 Protein with strong similarity to ras-related GTP-binding protein 2 (mouse Rab2), which plays a role in neuronal cell adhesion and may play a role in vesicle transport, member of the Ras superfamily of GTP-binding proteins RAS-related protein; unc-108 encodes a small GTPase homologous to the Rab GTPases that function in endocytosis, membrane fusion, and vesicular trafficking events; the precise biological role and expression pattern of unc-108 are not yet known. F53F10.5 F53F10.5 Protein of unknown function, has low similarity to a region of S. cerevisiae Nup116p, which is a nuclear pore protein (nucleoporin) that may be involved in binding and translocation of nuclear proteins F53F4.1 F53F4.1 Protein of unknown function chorion protein like F53F4.10 F53F4.10 Putative subunit of NADH-ubiquinone dehydrogenase, has strong similarity to human NDUFV2 (NADH dehydrogenase (ubiquinone) flavoprotein 2, 24 kDa subunit) NADH-ubiquinone dehydrogenase 24 KD subunit; F53F4.10 is orthologous to the human gene NADH-UBIQUINONE OXIDOREDUCTASE FLAVOPROTEIN 2 (NDUFV2; OMIM:600532), which when mutated is associated with susceptibility to Parkinson disease (OMIM:168600); F53F4.10 protein is predicted to be mitochondrial. F53F4.11 F53F4.11 Protein of unknown function, has moderate similarity to the N-terminus of H. sapiens Hs.129849 gene product, PBK1, which is expressed in first trimester placentae F53F4.12 F53F4.12 Protein of unknown function F53F4.13 F53F4.13 Protein of unknown function, has weak similarity to C. elegans F20A1.10 F53F4.14 F53F4.14 Protein with weak similarity to C. elegans F01F1.7 (Putative U5 snRNP-associated splicing factor, putative ortholog of human U5-100K protein and yeast Prp28p, member of the RNA helicase protein family) F53F4.2 F53F4.2 Protein of unknown function F53F4.3 F53F4.3 Protein containing a CAP-Gly domain, has moderate similarity to cytoskeleton-associated protein 1 (human CKAP1), which facilitates alpha-tubulin folding by forming complexes with alpha-tubulin folding intermediates S.pombe hypothetical protein SPAC4G9.01 like F53F4.4 F53F4.4 Protein of unknown function F53F4.5 F53F4.5 Member of the flavin-binding monooxygenase family, which are xenobiotic-metabolising enzymes, has moderate similarity to flavin containing monooxygenase 5 (mouse Fmo5) flavin-containing monoxygenase; fmo-14 encodes a protein with homology to human hepatic flavin-containing monooxygenase 5. F53F4.6 F53F4.6 Protein of unknown function F53F4.7 F53F4.7 Protein of unknown function, has low similarity to uncharacterized C. elegans Y48E1B.8 F53F4.8 F53F4.8 Member of the glycosyl hydrolases family 31, which are involved in carbohydrate metabolism, contains a P-type trefoil domain, has low similarity to lysosomal acid alpha-glucosidase (human GAA), which acts in glycogen catabolism glycosyl hydralase F53F4.9 F53F4.9 Protein of unknown function, has high similarity to uncharacterized C. elegans C39H7.7 7TM chemoreceptor (srd-family) F53F8.1 F53F8.1 Protein with strong similarity to human BTEB2 (basic transcription element binding protein 2) a zinc finger domain containing and GC box binding protein Zinc finger, C2H2 type (3 domains); The F53F8.1 gene encodes a homolog of human WT1, which when mutated leads to Wilms tumour (OMIM:194070). F53F8.2 F53F8.2 Putative ortholog of C. elegans M01B2.7 gene product F53F8.3 F53F8.3 Protein with weak similarity to H. sapiens ARFD1 (ADP-ribosylation factor domain protein 1, 64kD) Zinc finger, C3HC4 type (RING finger) F53F8.4 F53F8.4 Protein containing a DB module domain, has high similarity to uncharacterized C. elegans ZK1010.4 F53F8.5 F53F8.5 Protein containing a SAM (sterile alpha motif) domain, which may mediate protein-protein interactions F53G12.1 rab-11;Ce-rab11;F53G12.1 Protein with strong similarity to ras p21-like small GTP-binding protein 11a (mouse Rab11a), which is a putative GTPase that plays a role in phagocytosis, member of the Ras superfamily of GTP binding proteins RAS-related protein; rab-11.1 encodes a small GTPase homologous to the Rab GTPases that function in endocytosis, membrane fusion, and vesicular trafficking events; RAB-11.1 activity is required for completion of the final stages of cytokinesis during early embryogenesis and for efficient uptake of yolk proteins during oocyte development; RAB-11.1 is also required for normal peripheral localization of nuclei in the synctial germ cell in the ovary. F53G12.10 F53G12.10 Protein with high similarity to ribosomal protein L7 (human RPL7), which is an mRNA- and double-stranded DNA-binding putative large 60S ribosomal subunit component that is associated with systemic lupus erythematos, contains a ribosomal L30p or L7e domain ribosomal protein; rpl-7 encodes a large ribosomal subunit L7 protein required in mass RNAi assays for embryonic viability and normally rapid growth. F53G12.11 F53G12.11 Protein with weak similarity to H. sapiens TRAMP (putative Ac-like transposon) F53G12.3 F53G12.3 Protein with similarity to S. cerevisiae ferric reductases, putative paralog of C. elegans F56C11.1 and F53G12.2 F53G12.3 encodes a large partial homolog of dual oxidase ('Ce-Duox2'), with an N-terminal peroxidase domain, two central calmodulin-binding EF hands, and a C-terminal superoxide-generating NADPH-oxidase domain; F53G12.3 may be required for dityrosine cross-linking of collagen, and thus for cuticular integrity; F53G12.3 may use cytosolic NADPH to generate reactive oxygen, which then may drive the peroxidase ectodomain to cross-link free tyrosine in collagen; F53G12.3 has no visible expression pattern detectable by antibodies, implying very low or rare expression. F53G12.4 F53G12.4 Protein of unknown function F53G12.5 mex-3;F53G12.5 Involved in muscle development and possibly an RNA-binding; has similarity over the middle region to human far upstream element DNA-binding proteins FUBP and FBP3 mex-3 encodes two KH domain-containing RNA binding proteins; MEX-3 is required maternally in the early embryo for specifying the identities of the anterior AB blastomere and its descendants, as well as for the identity of the P3 blastomere and proper segregation of the germline P granules; mex-3 mRNA is distributed uniformly in the syncytial core of the adult distal gonad, mature oocytes, and early 1-cell stage embryos, but then becomes more prominent in the AB blastomere and its daughters by the 4-cell stage after which it is rapidly degraded save for the D and P4 blastomeres; MEX-3 protein is also detected uniformly in the cytoplasm of oocytes and 1-cell stage embryos, but like the mRNA, becomes more abundant in AB and its daughters at the 2- and 4-cell stages, respectively, before disappearing; MEX-3 is also detected in association with P granules from the 2-cell stage until the late stages of embryogenesis. F53G12.6 F53G12.6 Protein containing one protein kinase domain and one Src homology 2 (SH2) domain, which are regulatory modules of intracellular signaling, has low similarity to fer (fps/fes related) tyrosine kinase (mouse Fert2), which may mediate cell-cell signaling protein-tyrosine kinase F53G12.7 F53G12.7 Protein containing two collagen triple helix repeats, which are found in some extracellular proteins, and a nematode cuticle collagen N-terminal domain, has a region of moderate similarity to a region of collagen type II alpha 1 subunit (human COL2A1) cuticular collagen F53G12.8 F53G12.8 Protein of unknown function F53G12.9 F53G12.9 Protein with weak similarity to D. melanogaster fax (failed axon connections) F53G2.1 F53G2.1 Protein with weak similarity to C. elegans ZYG-11, which is required for zygote formation F53G2.2 F53G2.2 Protein with strong similarity to C. elegans F53G2.3 gene product F53G2.3 F53G2.3 Protein with strong similarity to C. elegans F53G2.2 gene product F53G2.4 F53G2.4 Putative ortholog of C. elegans F53G2.5 gene product The protein product of this gene is predicted to contain a glutamine/asparagine (Q/N)-rich ('prion') domain, by the algorithm of Michelitsch and Weissman (as of the WS77 release of WormBase, i.e., in wormpep77). F53G2.6 F53G2.6;CeTRN-SR;tsr-1 Protein with low similarity to transportin-SR (human TRN-SR), which binds specifically to phosphorylated serine/arginine (SR) domains and mediates nuclear import of SR domain-bearing protein splicing factors tsr-1 encodes a homolog of human transportin-SR, a nuclear transport receptor, and affects embryonic viability. F53G2.7 F53G2.7 Protein with low similarity to menage a trois 1 (human MNAT1), which is a CAK kinase (with human CDK7 and human CCNH) and TFIIH component that functions in CAK assembly, human POLR2A hyperphosphorylation, transcription, and nucleotide excision repair F53G2.8 F53G2.8 Protein of unknown function F53H1.3 F53H1.3 Protein of unknown function F53H1.4 F53H1.4 Protein containing a PHD-finger, which may be involved in chromatin-mediated transcriptional regulation F53H10.2 F53H10.2 Protein with weak similarity to C. elegans D1014.9 gene product Zinc finger, C2H2 type F53H2.1 F53H2.1 Protein of unknown function, has weak similarity to uncharacterized C. elegans B0507.6 F53H2.2 F53H2.2 Protein of unknown function F53H2.3 F53H2.3 Protein of unknown function F53H4.1 F53H4.1 Protein containing two SNF2 related N-terminal domains and a helicase conserved C-terminal domain, has a region of low similarity to a region of Cockayne's syndrome complementation group B (human ERCC6), which is a transcription-coupled DNA repair protein excision repair protein ERCC-6 like; csb-1 is orthologous to human gene ERCC6 (OMIM:133530, mutated in Cockayne syndrome); CSB-1 is required for embryonic viability, and represses UV-induced apoptosis in germ cells. F53H4.2 F53H4.2 Protein of unknown function F53H4.3 F53H4.3 Protein of unknown function F53H4.4 F53H4.4 Protein of unknown function F53H4.5 F53H4.5 Protein containing two SAND (Sp100, AIRE-1, NucP41/75 and DEAF-1/suppressin) domains, has a region of moderate similarity to a region of glucocorticoid modulatory element binding protein 2 (rat Gmeb2), which binds to rat Gmeb1 to regulate transcription SAND domain F53H8.1 F53H8.1 Protein with high similarity to adaptor-related protein complex 3 mu 1 subunit (human AP3M1), which is involved in targeting proteins with tyrosine-based signals to lysosomes, member of the clathrin adaptor complexes medium chain family clathrin coat assembly protein; apt-7 gene encodes an adaptin, orthologous to the mu3 subunit of adaptor protein complex 3 (AP-3); APT-7 is also orthologous to human HPS, which when mutated leads to Hermansky-Pudlak syndrome (OMIM:203300); based on structural similarity, APT-7 may be involved in the formation of intracellular transport vesicles. F53H8.2 F53H8.2 Protein with high similarity to beta-arrestin 1 (rat Arrb1), which is an adaptor protein regulating desensitization and internalization of G protein-coupled receptors, contains C-terminal and N-terminal arrestin (or S-antigen) domains beta-arrestin; arr-1 encodes the C. elegans beta-arrestin ortholog (OMIM:107940, 107941, mice lacking beta-arrestin family members display defects in G protein-coupled receptor desensitization); by homology, ARR-1 is predicted to be a multifunctional adaptor protein that interacts with intracellular signaling molecules as well as activated and phosphorylated G protein-coupled and TGF-beta receptors to: 1) downregulate receptor signaling, 2) promote receptor endocytosis, and 3) activate MAP kinase- and Src-dependent signaling pathways; in C. elegans, loss of arr-1 function via mutation or RNAi does not result in any obvious abnormalities and, in particular, does not appear to affect chemosensation or odorant discrimination; however, animals doubly mutant for arr-1 and grk-2, which encodes a G protein-coupled receptor kinase, are sick and slow growing; an arr-1 transcriptional reporter is expressed in neurons, including the ASH chemosensory neurons, and in the intestine. F53H8.3 F53H8.3 Member of the sugar (and other) transporter family, has low similarity to solute carrier family 2 member 1 (human SLC2A1), which is associated with Glut-1 Deficiency Syndrome and glucose transporter protein syndrome upon gene mutation glucose transporter F53H8.4 F53H8.4 Protein of unknown function, has low similarity to uncharacterized C. elegans Y22D7AL.8 F54A3.1 F54A3.1 Putative ortholog of C. elegans T08D2.E gene product F54A3.2 F54A3.2 Putative ortholog of C. elegans F54A3.G gene product F54A3.3 F54A3.3 Putative ortholog of C. elegans F54A3.F gene product F54A3.4 F54A3.4 Putative ortholog of C. elegans F54A3.D gene product The F54A3.4 gene encodes a homolog of the human gene CBS, which when mutated leads to homocystinuria (OMIM:236200). F54A3.5 F54A3.5 Protein with strong similarity to C. elegans F54A3.C gene product F54A3.6 F54A3.6 Putative ortholog of C. elegans F54A3.B gene product F54A5.1 F54A5.E;F54A5.1 Protein containing two homeobox domains (homeodomains), which are found in transcription factors F54A5.3 F54A5.3 Protein containing a Src homology 2 (SH2) domain, which are regulatory modules of intracellular signaling, has a region of low similarity to a region of src homology 2 domain-containing transforming protein 1 (human SHC1) F54A5.3 encodes four proteins by multiple splicing, three of which are rather small (52-81 residues); however, one isoform (F54A5.3A, 316 residues) is a ortholog of vertebrate Shc proteins (e.g., p52/p46SHC and p66SHC); like its orthologs, F54A5.3A has a PTB and an SH2 domain in N- to C-terminal order; F54A5.3 has no obvious function in mass RNAi assays, but might be involved in RAS signal transduction or regulation of apoptosis. F54A5.C F54A5.2;F54A5.C Protein contains a ZP (Zona pellucida) domain, contains C. elegans telomere-like hexamer repeat CeRep26; may be anchored to the membrane of a secretory vesicle or the Golgi apparatus F54B11.1 col-9;F54B11.1 Protein with strong similarity to human COL9A1, alpha-1 collagen, type IX collagen; col-9 encodes a collagen protein. F54B11.10 F54B11.10 Protein of unknown function F54B11.11 F54B11.11 Protein of unknown function, has low similarity to uncharacterized C. elegans F35E12.10 F54B11.2 F54B11.2;col-9 Protein with high similarity to C. elegans SQT-3, which is a collagen, contains two collagen triple helix repeats, which are found in some extracellular proteins, and a nematode cuticle collagen N-terminal domain collagen F54B11.3 unc-84;F54B11.3 Required for nuclear migration and anchoring unc-84 encodes a transmembrane protein that contains a SUN domain with homology to S. pombe Sad1 and affects nuclear migration and anchoring of various cell types together with UNC-83 and ANC-1, thereby affecting coordinated locomotion, vulval formation, and egg laying; UNC-84 is localized to the nuclear envelope and requires LMN-1 for this localization, and it is expressed in the nuclear envelope of essentially all adult and embryonic cells. F54B11.4 F54B11.4 Protein of unknown function F54B11.5 F54B11.5 Protein of unknown function Zinc finger, C3HC4 type (RING finger) F54B11.6 bra-1;F54B11.6 Protein containing an MYND finger domain, has moderate similarity to a region of adenovirus 5 E1A binding protein (human BS69), which represses human MYB and adenovirus E1A-activated transcription F54B11.7 F54B11.7 Protein with strong similarity to C. elegans T23B12.10 gene product F54B11.8 F54B11.8 Protein of unknown function F54B11.9 F54B11.9 Protein of unknown function F54B3.1 F54B3.1 Protein of unknown function ATP binding protein (CDC48/PAS1/SEC18 family) F54B3.2 F54B3.2 Protein of unknown function F54B3.3 F54B3.3 Member of the ATPase family associated with various cellular activities, has weak similarity to S. cerevisiae Rpt5p, which is an ATPase component of 26S proteasome complex that functions in RNA polymerase II transcription elongation ATPases associated with various cellular activities (AAA) F54B8.1 F54B8.1 Protein of unknown function, has strong similarity to uncharacterized C. elegans M01B2.8 F54B8.10 F54B8.10 Protein containing a DUF40 domain of unknown function, which contain four conserved cysteines, has high similarity to uncharacterized C. elegans F54B8.9 7TM receptor, srbc family F54B8.11 F54B8.11 Protein containing a DUF40 domain of unknown function, which contain four conserved cysteines, has high similarity to uncharacterized C. elegans F54B8.9 7TM receptor, srbc family F54B8.12 F54B8.12 Protein containing two DUF40 domains of unknown function, which contain four conserved cysteines, has low similarity to uncharacterized C. elegans R09E12.1 7TM receptor, srbc family F54B8.2 F54B8.2 Protein containing a nuclear hormone receptor ligand-binding domain, has low similarity to a region of C. elegans NHR-51, which is involved in developmental processes Ligand-binding domain of nuclear hormone receptors F54B8.3 F54B8.3 Protein containing an F-box domain, which serve as a link between a target protein and a ubiquitin-conjugating enzyme, and a DUF38 domain of unknown function, has low similarity to C. elegans FOG-2, which is required for the sexual identity of germ cells This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins; this gene's encoded protein also contains an FTH/DUF38 motif, which may also mediate protein-protein interaction. F54B8.4 F54B8.4 Protein of unknown function, has moderate similarity to C. elegans T28F4.5 The F54B8.4 gene encodes a homolog of Death Associated Protein 1 (DAP-1) protein that may be involved in apoptosis. F54B8.5 F54B8.5 Protein of unknown function, has high similarity to uncharacterized C. elegans T22H6.5 abf-3 encodes a homolog of the antibacterial factor ASABF from Ascaris suum; ABF-3 may play a role in innate immunity, though at present the only evidence for its having an antimicrobial humoral function is its sequence similarity. F54B8.6 F54B8.6 Protein containing a DUF40 domain of unknown function, which contain four conserved cysteines, has high similarity to uncharacterized C. elegans F54B8.7 7TM receptor, srbc family F54B8.7 F54B8.7 Protein containing a DUF40 domain of unknown function, which contain four conserved cysteines, has high similarity to uncharacterized C. elegans F54B8.6 7TM receptor, srbc family F54B8.8 F54B8.8 Protein containing a DUF40 domain of unknown function, which contain four conserved cysteines, has high similarity to uncharacterized C. elegans F54B8.9 7TM receptor, srbc family F54B8.9 F54B8.9 Protein containing a DUF40 domain of unknown function, which contain four conserved cysteines, has high similarity to uncharacterized C. elegans F54B8.10 7TM receptor, srbc family F54C1.1 F54C1.1 Protein containing a UDP-glucoronosyl and UDP-glucosyl transferase domain, has a region of low similarity to a region of UDP-glucuronosyltransferase 8 (UDP-galactose ceramide galactosyltransferase, rat Ugt8), which acts in galactosylceramide synthesis F54C1.2 dom-3;F54C1.2 Protein of unknown function, has low similarity to uncharacterized mouse Dom3z F54C1.3 mes-3;F54C1.3 Required for germ line proliferation and maintenance mes-3 encodes a novel protein with no discernible motifs; however, as a member of a Polycomb-like chromatin repressive complex with MES-2 and MES-6, MES-3 is required maternally for normal germline development and during larval development, for anteroposterior patterning; during germline development, the MES-2/MES-3/MES-6 complex is believed to be essential for maintaining repression of the X chromosome, and in transgenic animals, the complex is necessary for germline repression of repetitive transgenes; in axial patterning, the MES-2/MES-3/MES-6 complex is required in somatic tissues for maintaining homeotic gene repression, acting upstream of the Hox genes lin-39, mab-5, and egl-5, as well as the egl-5 target gene lin-32; MES-3 expression is detected in the nuclei of all cells during early embryogenesis, in some somatic cells and the germline precursors Z2 and Z3 during late embryogenesis and the L1 larval stage; in adults, MES-3 is expressed at highest levels in oocytes and germline nuclei in the proximal meiotic region with expression in the pachytene region negatively regulated by the RNA-binding protein GLD-1; MES-3 appears to be localized primarily to the nucleoplasm with some chromosomal association detectable during metaphase and early anaphase; in >24-cell-stage embryos, normal MES-3 levels and localization are dependent upon wild-type activity of MES-2 and MES-6. F54C1.5 F54C1.5 Protein of unknown function F54C1.6 F54C1.6 Protein of unknown function F54C1.7 tnc-1;pat-10;F54C1.7 Protein containing four EF hand domains, has moderate similarity to calmodulin 1 (human CALM1), which regulates the calcium-dependent activity of proteins and enzymes including ion channels, kinases, phosphatases, and phosphodiesterases calcium binding protein; pat-10 encodes body wall muscle troponin C, the calcium-binding component of the troponin complex of actin thin filaments; PAT-10 is essential for muscle contraction and thus for completion of embryonic morphogenesis and elongation; by homology, PAT-10 likely functions to regulate body wall muscle contraction in response to changes in intracellular calcium; PAT-10 is expressed in body wall muscle but is also detected in vulval and anal muscles; expression in body wall muscle begins during early embryonic morphogenesis, concurrent with expression of other body wall muscle structural components. F54C1.8 F54C1.8 Protein with moderate similarity to C. elegans F59C6.3 gene product F54C1.9 sst-20;F54C1.9 Protein of unknown function; may be required for spermatogenesis F54C4.1 F54C4.1 Protein of unknown function, has weak similarity to human nuclear localization signal containing protein NLVCF, involved in velocardiofacial syndrome F54C4.2 F54C4.2 Protein with high similarity to suppressor of Ty (S.cerevisiae) 4 homolog 1 (human SUPT4H1), which is part of the DRB sensitivity inducing factor that binds RNA Pol II, regulates transcription elongation, and may modulate chromatin assembly and activity F54C4.3 F54C4.3 Protein of unknown function zinc finger protein F54C4.4 F54C4.4 Protein of unknown function F54C8.1 F54C8.1 Protein with high similarity to short chain L-3-hydroxyacyl-Coenzyme A (human HADHSC), which is involved in fatty acid beta oxidation and is associated with hyperinsulinism, contains 3-hydroxyacyl-CoA dehydrogenase C-terminal and NAD binding domains 3-hydroxyacyl-CoA dehydrogenase F54C8.2 F54C8.2 Member of the histone H3 protein family Histone H3 similarity F54C8.3 emb-30;apc-4;F54C8.3 Maternally required for embryonic development apparently acting in cell division; loss of protein function leads to anucleate spermatids emb-30 encodes an anaphase-promoting complex/cyclosome (APC/C) component orthologous to mammalian APC-4 and Schizosaccharomyces pombe Lid1; EMB-30 is required for the metaphase-to-anaphase transition during meiosis and mitosis, for establishing anterior-posterior polarity in the early embryo, and for proper localization of germline granules and the maternally provided PAR-2 and PAR-3 proteins. F54C8.4 F54C8.4 Protein of unknown function, has a region of low similarity to dual specificity phosphatase 11 (human DUSP11), which is a nuclear dual specificity phosphatase associated with RNA and ribonucleoprotein complexes and has protein and RNA phosphatase activity Protein-tyrosine phosphatase F54C8.5 F54C8.5 Member of the Ras superfamily of GTP binding proteins, has moderate similarity to ras homolog enriched in brain 2 (human RHEB2), which is a putative small monomeric GTPase that binds GTP and may play a role in signal transduction Ras family F54C8.6 F54C8.6 Protein with similarity to mouse Rae-38, a 3-hydroxyacyl CoA dehydrogenase F54C8.7 F54C8.7 Protein with low similarity to partner of RAC1 (human POR1), which is a RAC1 GTPase and ADP-ribosylation factor binding protein that is involved in actin cytoskeleton rearrangement during cellular membrane ruffling and lamellipodia formation F54C9.1 F54C9.1 Protein with high similarity to translation initiation factor eIF5A (S. cerevisiae Hyp2p), contains a eukaryotic initiation factor 5A hypusine DNA-binding OB fold domain and a eukaryotic initiation factor 5A hypusine SH3-like barrel domain initiation factor 5A F54C9.10 F54C9.10 Protein with high similarity to ADP-ribosylation factor 1 (rat Arl1), which is a GTP-binding protein and putative GTPase that may be involved in intracellular protein transport, member of the ADP-ribosylation factor (ARF) family GTP-binding ADP-ribosylation factor; arl-1 encodes a member of the GTP-binding ADP-ribosylation factor family. F54C9.11 F54C9.11 Protein of unknown function, has low similarity to a region of rabin 3 (rat RABIN3), which is a Rab3-interacting protein that associates with rat Rab3A and rat Rab3D (rat Rn.9822) F54C9.2 STCH;F54C9.2 Member of the heat shock HSP70 protein family with homology to human and rat STCH Heat shock 70Kd protein (HSP70) F54C9.3 F54C9.3 Protein of unknown function F54C9.4 col-38;F54C9.4 Protein containing two collagen triple helix repeats and a nematode cuticle collagen N-terminal domain, has a region of high similarity to a region of C. elegans BLI-1, which is a likely collagen that acts in embryogenesis and morphogenesis and chemotaxis collagen; col-38 encodes a member of the collagen superfamily containing collagen triple helix repeats (20 copies) required for normal body morphology. F54C9.5 rpl-5;F54C9.5 Protein with high similarity to ribosomal protein L5 (human RPL5), which is a 60S ribosomal subunit protein that binds 5S rRNA, undergoes nuclear export, and is associated with colorectal cancer and astrocytomas, member of the ribosomal L18p or L5e family 60S ribosomal protein L5; rpl-5 encodes a large ribosomal subunit L5 protein; by homology, RPL-5 is predicted to function in protein biosynthesis; in C. elegans RPL-5 activity is broadly required for embryonic, larval, germline, and vulval development, as well as normal body coloration, morphology, and postembryonic growth rates. F54C9.6 F54C9.6 Protein with high similarity to bcs1-like (human BCS1L), which is a mitochondrial respiratory chain complex III subunit associated with tubulopathy, encephalopathy, and liver failure, member of the ATPase family associated with various cellular activities ATP-binding protein (CDC48/PAS1/SEC18 family); F54C9.6 encodes a protein orthologous to the human mitochondrial protein BCS1 (YEAST HOMOLOG)-LIKE (BCS1L; OMIM:603647); mutation of BCS1L leads to neonatal tubulopathy, encephalopathy, and liver failure, or to GRACILE syndrome. F54C9.7 F54C9.7 Protein of unknown function F54C9.8 puf-5;F54C9.8 Member of the pumilio repeat protein family; appears to be required for appropriate germline development Pumilio-family RNA binding domains (aka PUM-HD, Pumilio homology domain) (6 domains) F54C9.9 F54C9.9 Protein with weak similarity to S. cerevisiae Kel1p (protein involved in cell fusion and morphology) F54D1.1 F54D1.1 Protein of unknown function, has a region of moderate similarity to a region of C. elegans GLD-1, which is an RNA binding protein required for transition from mitosis to meiosis during spermatogenesis and oogenesis in hermaphrodites F54D1.2 F54D1.2 Protein containing two collagen triple helix repeats and a nematode cuticle collagen N-terminal domain, has moderate similarity to a region of C. elegans BLI-1, which is a likely collagen, which functions in embryogenesis and morphogenesis and chemotaxis collagen F54D1.3 F54D1.3 Protein containing two collagen triple helix repeats and a nematode cuticle collagen N-terminal domain, has moderate similarity to a region of C. elegans BLI-1, which is a putative collagen that functions in embryogenesis and morphogenesis and chemotaxis collagen F54D1.4 nhr-7;F54D1.4 Member of the nuclear hormone receptor protein family nuclear hormone receptor F54D1.5 F54D1.5 Member of the ion transport family, which include calcium, sodium, and potassium channels, has low similarity to transient receptor potential channel (human TRPM7), which is a ligand-gated cation channel gtl-2 encodes a predicted receptor-activated calcium channel and represents a family of calcium channels, the other two family members being gtl-1 and gon-2. F54D1.6 F54D1.6 Protein of unknown function, has high similarity to uncharacterized C. elegans R09E10.5 F54D10.1 skr-15;F54D10.1 Member of the Skp1 family, has a region of low similarity to a region of S. cerevisiae Skp1p, which is a component (subunit D) of Cbf3 kinetochore and SCF (Skp1p-cullin-F-box) complexes and is involved in ubiquitin-dependent degradation The skr-15 gene encodes a homolog of Skp1 in S. cerevisiae that has no known function in vivo, since skr-15(RNAi) animals are at least superficially normal. F54D10.2 F54D10.2 Protein containing a DUF38 domain of unknown function, has low similarity to a region of C. elegans FOG-2, which is required for the sexual identity of germ cells F54D10.3 F54D10.3 Protein of unknown function, has low similarity to uncharacterized C. elegans C41H7.4 F54D10.4 F54D10.4 Protein with weak similarity to H. sapiens GOLGB1 (golgi autoantigen, golgin subfamily b, macrogolgin (with transmembrane signal), 1) F54D10.5 F54D10.5 Protein of unknown function F54D10.6 F54D10.6 Protein containing two DUF38 domains of unknown function and an F-box domain, which serves as a link between a target protein and a ubiquitin-conjugating enzyme, has low similarity to uncharacterized C. elegans C39B5.9 This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins; this gene's encoded protein also contains an FTH/DUF38 motif, which may also mediate protein-protein interaction. F54D10.7 F54D10.7 Member of the ubiquitin family F54D10.8 F54D10.8 Protein containing a DUF138 domain of unknown function, has moderate similarity to uncharacterized C. elegans R05A10.6 F54D10.9 F54D10.9 Protein of unknown function, has moderate similarity to C. elegans C04G6.2 F54D11.1 F54D11.1 Member of the ubiE or COQ5 methyltransferase family F54D11.2 F54D11.2 Protein of unknown function, has a region of weak similarity to a region of heavy polypeptide of neurofilament (mouse Nfh), which is a structural protein that may regulate axonal caliber, synaptic transmission, and type IV intermediate filament assembly F54D11.3 F54D11.3 Protein of unknown function, has moderate similarity to C. elegans F16B12.6 F54D11.4 F54D11.4 Protein of unknown function F54D12.1 F54D12.1 Protein of unknown function, has moderate similarity to C. elegans F54D12.7 F54D12.2 F54D12.2 Protein with moderate similarity to C. elegans F54D12.7 gene product F54D12.3 F54D12.3 Protein with low similarity to solute carrier family 7 member 11 (human SLC7A11), which is a high affinity cystine and glutamate transporter that requires the heavy chain of 4F2 cell surface antigen for activity F54D12.4 F54D12.4 Protein of unknown function F54D12.5 F54D12.5 Protein of unknown function F54D12.6 F54D12.6 Protein containing an insulin receptor substrate-1-like phosphotyrosine-binding (PTBI) domain, has low similarity to a region of Suc1-associated neurotrophic factor target 2 (human SNT-2), which binds to and is tyrosine phosphorylated by human FGFR1 F54D12.7 F54D12.7 Protein with strong similarity to C. elegans F54D12.1 gene product F54D12.8 F54D12.8 Protein of unknown function, has weak similarity to C. elegans F54D12.1 F54D5.1 CePCS;ce-pcs-1;pcs-1;PCS;F54D5.1 Phytochelatin synthase; may function to resist toxicity to heavy metals phytochelatin synthase F54D5.11 TFIIE-beta;F54D5.11 Transcription initiation factor TFIIE-beta transcription intiation factor TFIIE-BETA F54D5.12 F54D5.12 Protein with high similarity to mitochondrial d-lactate dehydrogenase (S. cerevisiae Dld2p), which is involved in pyruvate and lactate metabolism, contains a FAD-binding domain and a FAD-linked oxidase C-terminal domain, which have a ferredoxin-like fold yeast hyothetical YET1 like protein F54D5.14 F54D5.14 Protein with low similarity to S. pombe Rad18p, which functions in DNA repair F54D5.15 F54D5.15 Protein of unknown function F54D5.2 F54D5.2 Protein of unknown function F54D5.3 F54D5.3 Protein of unknown function, has high similarity to uncharacterized C. elegans F54D5.4 F54D5.4 F54D5.4 Protein of unknown function, has high similarity to uncharacterized C. elegans F54D5.3 F54D5.5 F54D5.5 Protein of unknown function, has weak similarity to C. elegans C17E7.4 F54D5.7 F54D5.7 Member of the acyl-CoA dehydrogenase protein family acyl-CoA dehydrogenase; The F54D5.7 gene encodes an ortholog of the human gene GLUTARYL-COENZYME A DEHYDROGENASE (GCDH), which when mutated leads to glutaricaciduria type I (OMIM:231670). F54D5.8 F54D5.8 Protein with high similarity to dnaJ (Hsp40) homolog, subfamily B, member 1 (human DNAJB1), contains a DnaJ C-terminal domain and a DnaJ domain, which are part of chaperone (protein folding) system that mediates interaction with heat shock proteins DNAJ protein; This gene encodes a protein containing a DnaJ ('J') domain. F54D5.9 F54D5.9 Protein of unknown function This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins. F54D7.1 F54D7.1 Member of the reverse transcriptase protein family, which are RNA-dependent DNA polymerases, has very strong similarity to uncharacterized C. elegans F28E10.3 reverse transcriptase F54D7.2 F54D7.2 Protein with strong similarity to C. elegans Y49A3A.A, has similarity to CDP-alcohol phosphotransferases F54D7.3 F54D7.3 Member of the rhodopsin family of G protein-coupled receptors (GPCR), has low similarity to gonadotropin-releasing hormone receptor (mouse Gnrhr), which activates phospholipase C, stimulates phosphoinositide turnover and regulates reproductive function seven-transmemebrane receptor; F54D7.3 is orthologous to the human gene GONADOTROPIN RELEASING HORMONE RECEPTOR (GNRHR; OMIM:138850), which when mutated leads to disease. F54D7.4 zig-7;F54D7.4 Protein containing two immunoglobulin (Ig) domains, which may be involved in protein-protein and protein-ligand interactions F54D7.5 F54D7.5 Protein of unknown function F54D7.6 F54D7.6 Protein of unknown function F54D7.7 F54D7.7 Protein of unknown function F54D8.1 F54D8.1 Protein containing two collagen triple helix repeats and one nematode cuticle collagen N-terminal domain, has moderate similarity to C. elegans SQT-1, which is a collagen Uncloned locus that affects body length and outgrowth of posterior canal cell processes. F54D8.2 F54D8.2 Member of the cytochrome c oxidase subunit VIa family, which are small polypeptidic subunits of cytochrome c Cytochrome C oxidase F54D8.3 F54D8.3 Member of the aldehyde dehydrogenase protein family Aldehyde dehydrogenase 2; alh-1 is orthologous to the human gene ALDEHYDE DEHYDROGENASE 2, MITOCHONDRIAL (ALDH2; OMIM:100650), in which a polymorphism can lead to acute ethanol intolerance. F54D8.4 F54D8.4 Protein containing a eukaryotic-type carbonic anhydrase domain, which catalyze reversible hydration of carbon dioxide, has low similarity to carbonic anhydrase 2 (human CA2), which catalyzes hydration of carbon dioxide to form bicarbonate ion and a proton carbonic anhydrase I; cah-1 encodes a member of the carbonic anhydrase family. F54D8.5 F54D8.5 Protein of unknown function, has high similarity to uncharacterized C. elegans T09F5.7 F54E12.1 F54E12.1 Member of the histone H3 protein family histone H3; his-55 encodes an H3 histone; by homology, HIS-55 is predicted to function as a nucleosome component required for packaging of DNA into chromatin; his-55 is a replication-dependent histone locus that resides in a histone gene-rich region on chromosome IV. F54E12.2 F54E12.2 Protein containing a helicase conserved C-terminal domain and an SNF2 related N-terminal domain, has low similarity to S. cerevisiae Rad16p, which is a nucleotide excision repair protein involved in G2 repair of inactive genes helicase F54E12.3 F54E12.3 Member of the histone H4 protein family histone H4; his-56 encodes an H4 histone. F54E12.4 F54E12.4 Member of the histone H2B protein family histone H2B; his-58 encodes an H2B histone. F54E12.5 F54E12.5 Member of the histone H2A protein family histone H2A; his-57 encodes an H2A histone. F54E2.1 F54E2.1 Protein of unknown function, has low similarity to uncharacterized C. elegans B0024.4 F54E2.5 F54E2.5 Putative ortholog of C. elegans F58F6.6 gene product F54E2.6 F54E2.6 Protein containing a DUF32 domain of unknown function, has high similarity to uncharacterized C. elegans C53A5.10 7TM chemoreceptor, srt family F54E4.1 F54E4.1 Protein with strong similarity to D. melanogaster DMX and human DMXL1 (DMX-like) proteins Drosophila protein X like F54E4.2 F54E4.2 Protein with weak similarity to H. sapiens OPRK1 (opioid receptor, kappa 1) 7 transmembrane receptor (rhodopsin family) F54E4.3 F54E4.3 Protein of unknown function F54E4.4 F54E4.4 Protein with strong similarity to C. elegans C34G6.2 gene product zinc metalloprotease F54E7.1 F54E7.1 Protein with weak similarity to S. cerevisiae Hut1p, which is involved in native disulfide bond formation in endoplasmic reticulum F54E7.2 F54E7.2 Member of the ribosomal S12e protein family rps-12 encodes a small ribosomal subunit S12 protein; by homology, RPS-12 is predicted to function in protein biosynthesis; in C. elegans, RPS-12 activity is required for embryonic and germline development, normal movement, and the overall health of the animal. F54E7.3 par-3;F54E7.3 Protein required for the asymmetric distribution of P granules and other factors during embryogenesis; likely involved in establishing anteroposterior polarity par-3 encodes a PDZ domain-containing protein orthologous to mammalian atypical PKC isotype-specific interacting protein (ASIP) and Drosophila Bazooka that is required maternally for polarization of the zygote along the anterior-posterior (A-P) axis; PAR-3, PAR-6, and PKC-3 form a complex that localizes to the anterior cytoplasmic cortex of the one- and two-cell embryo; this localization is regulated spatially by PAR-2, which segregates to the posterior cortex. F54E7.5 F54E7.5 Protein of unknown function, has weak similarity to C. elegans C05B5.4 F54E7.6 F54E7.6 Protein of unknown function F54E7.7 dscr1L;F54E7.7 Protein with moderate similarity to Down syndrome critical region gene homolog 1 (myocyte-enriched calcineurin interacting protein 1, mouse Dscr1), which inhibits calcineurin A (Ppp3CA)-dependent pathways and is associated with Down's syndrome in humans rcn-1 encodes a calcipressin, which binds and inhibits calcineurin; RCN-1's orthologs include yeast Rcn1p and human DSCR1 (OMIM:602917; overexpressed in Down syndrome and Alzheimer disease); rcn-1 is expressed in hypodermal seam cells, various neurons, vulval epithelial and muscle cells, marginal pharyngeal cells, and in the male tail; rcn-1 transcription is regulated by TAX-6, and RCN-1 binds TAX-6 protein if free Ca[2+] is present; RCN-1 overexpression, like calcineurin deficiency, causes defects in body size, cuticle thickness, fertility, growth rate, and serotonin-resistance in egg-laying. F54E7.8 F54E7.8 Protein of unknown function F54E7.9 F54E7.9 Protein with weak similarity to C. elegans Y97E10AL.3 gene product F54F11.1 F54F11.1 Protein of unknown function F54F11.2 F54F11.2 Member of the M13 peptidase family of zinc metalloproteases, has a region of low similarity to mel transforming oncogene-like 1 (soluble secreted endopeptidase, mouse Mell1), which is a metalloprotease that may be involved in sperm formation Zinc-binding metalloprotease; F54F11.2 encodes a neprilysin; neprilysins are thermolysin-like zinc metallopeptidases, found on the outer surface of animal cells, that negatively regulate small signalling peptides (e.g., enkephalin, tachykinin, insulin, and natriuretic peptides) by cleaving them; F54F11.2 has no clear orthologs in other organisms. F54F11.3 F54F11.3 Member of the C. elegans Sre G protein-coupled chemoreceptor family, which are putative chemosensory receptors, has moderate similarity to uncharacterized C. elegans Y39G8B.3 7TM receptor, sre family F54F12.1 F54F12.1 Member of the protein-tyrosine phosphatase family, which are involved in control of cell growth, proliferation, differentiation and transformation, has a region of weak similarity to a region of human PTPRA, which is a receptor type tyrosine phosphatase tyrosine protein phosphatase F54F12.2 F54F12.2 Protein of unknown function F54F2.1 F54F2.1 Protein containing five integrin alpha chain repeat domains and an alpha integrin cytoplasmic domain, has low similarity to alpha V subunit integrin (mouse Itgav), which is a subunit of the vitronectin receptor that is involved in cell adhesion Vitronectin receptor alpha subunit F54F2.2 zfp-1;CEZF;F54F2.2 Putative transcription factor with high similarity to H. sapiens AF10 over the zinc finger and leucine zipper domains zfp-1 encodes a leucine zipper, zinc finger, and PHD/LAP domain (plant homeodomain/leukemia-associated protein)-containing protein homologous to human AF10 (OMIM:602409, which is involved in chromosomal translocations associated with acute leukemia); loss of zfp-1 activity via RNA-mediated interference (RNAi) results in suppression of RNAi, suggesting that ZFP-1 plays a role in gene silencing; based on sequence similarity, ZFP-1 is predicted to associate with chromatin. F54F2.5 F54F2.5 Protein containing four C2H2 type zinc finger domains, which bind nucleic acids F54F2.6 F54F2.6 Protein of unknown function F54F2.7 F54F2.7 Protein of unknown function, has low similarity to uncharacterized human FLJ20457 F54F2.8 F54F2.8 Protein with low similarity to peroxisomal farnesylated protein (human PXF), which is a peroxisomal protein that binds several peroxisomal membrane proteins (PMP) and is involved in early stages of PMP import and peroxisomal biogenesis prx-19 is orthologous to the human gene PEROXISOMAL FARNESYLATED PROTEIN (PXF; OMIM:600279), which when mutated leads to peroxisome biogenesis (Zellweger) syndrome of complementation group J. F54F2.9 F54F2.9 Protein containing a Myb-like DNA-binding domain, has a region of low similarity to a region of zuotin related factor 1 (mouse Zrf2), which exhibits both sequence-specific DNA binding and Z-DNA binding that is inhibited by interaction with mouse Idb1 F54F3.1 nid-1;F54F3.1 Basement membrane glycoprotein; member of EGF-like repeat protein family; strongly similar to human basement membrane protein nidogen (entactin) nidogen like F54F3.3 F54F3.3 Member of the alpha or beta hydrolase fold family, has moderate similarity to lysosomal acid lipase A (human LIPA), which deacylates cholesteryl and triacylglyceryl ester lipids and is associated with Wolman disease and cholesteryl ester storage disease lipase F54F3.4 F54F3.4 Member of the alcohol/ribitol dehydrogenase-like protein family dehydrogenase; This gene encodes a protein predicted by Eisenberg and coworkers, with 68% accuracy, to be mitochondrial. F54F7.1 taf-8.1;F54F7.1 Protein of unknown function, has low similarity to a region of TATA box binding protein (TBP) associated factor RNA polymerase II F 55kD (human TAF7), which is a component of TFIID complex that is a transcriptional coactivator The taf-7.1 gene encodes an ortholog of mammalian TATA-binding protein associated factor TAF7L (TAFIIQ, OMIM:300314) that in mice exhibits testis-specific expression; TAF-7 function in C. elegans is not yet known, as taf-7 inactivation by RNA interference does not result in any obvious developmental defects. F54F7.2 F54F7.2 Protein of unknown function F54F7.3 F54F7.3 Protein of unknown function F54F7.4 trx-1;F54F7.4 Protein of unknown function, has a region of high similarity to a region of C. elegans TRA-2, which is a transmembrane protein that promotes female development in animals that have two X chromosomes TRA-2 like protein; xtr-1 encodes a protein with similarity to TRA-2A and TRA-2B in a region known as the MX region, hypothesized to be a protein-protein interaction domain involved in negatively regulating tra-2 activity in the germ line. F54F7.5 mes-1;F54F7.5 Protein containing two protein kinase domains, has high similarity to uncharacterized C. elegans B0198.3 tyrosine-protein kinase; The mes-1 gene encodes a receptor tyrosine kinase-like protein that is required for unequal cell divisions in the early embryonic germline; during embryonic cell divisions, mes-1 is involved in positioning of the early mitotic spindle and of associated P granules. F54F7.6 F54F7.6 Protein with weak similarity to C. elegans R04D3.2 F54F7.7 F54F7.7 Protein of unknown function, has a region of low similarity to a region of S. cerevisiae Dot1p, which is involved in silencing at telomeres and other repressed loci and meiotic arrest checkpoint F54G2.1 F54G2.1 Protein containing a C2 domain, which may be involved in calcium-dependent phospholipid binding, has low similarity to BAI1-associated protein 3 (human BAIAP3), which interacts with the cytoplasmic domain of BAI1 and may regulate neurotransmitter release F54G2.2 F54G2.2 Protein containing a zinc knuckle domain, which can bind RNA or DNA in eukaryotes F54G8.1 F54G8.1 Protein containing a DUF41 domain of unknown function, has weak similarity to uncharacterized C. elegans T26E4.1 F54G8.2 F54G8.2 Protein with high similarity to diacylglycerol kinase 90 kDa (rat Dagk), contains two phorbol esters or diacylglycerol binding domains (C1 domain), two EF hand domains, and diacylglycerol kinase (DAGK) catalytic and accessory domains Diacylglycerol kinase F54G8.3 ina-1;F54G8.3 Alpha integrin subunit; required for normal axonal migration and fasciculation and for normal morphogenesis of multiple tissues Integrin alpha chain F54G8.4 F54G8.4 Protein containing a C3HC4 type (RING) zinc finger, which may mediate protein-protein interactions, and six NHL repeats, has weak similarity to ring finger protein 22 (tripartite motif 3 protein, human TRIM3), which interacts with myosin V molecular motor Zinc finger, C3HC4 type (RING finger); The nhl-1 gene encodes an RBCC protein, orthologous to the mammalian protein BERP; its C. elegans paralogs include ncl-1 and lin-41. F54G8.5 F54G8.5 Putative ortholog of C. elegans ptr gene product F54H12.1 F54H12.1 Protein with high similarity to aconitase 2 mitochondrial (aconitate hydratase, human ACO2), which converts citrate to cis-aconitate in the tricarboxylic acid cycle, member of the aconitate hydratase family, contains two aconitase C-terminal domains Aconitate hydratase; aco-2 encodes an aconitase homolog that is required for embryonic viability, fertility, locomotion, and vulval morphogenesis, and perhaps for normal lifespan; ACO-2 is predicted to be mitochondrial. F54H12.2 F54H12.2 Protein of unknown function, putative paralog of C. elegans K09F6.5 F54H12.3 F54H12.3 Protein containing a retroviral integrase core domain, which are the central catalytic domains that can act as endonucleases F54H12.4 F54H12.4 Protein of unknown function, has very strong similarity to uncharacterized C. elegans Y57G11C.18 F54H12.5 F54H12.5 Protein containing an F-box domain, which serve as a link between a target protein and a ubiquitin-conjugating enzyme This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins. F54H12.6 F54H12.6 Protein with high similarity to translation elongation factor 1-beta (S. pombe Tef5p), contains an elongation factor 1 (EF-1) guanine nucleotide exchange domain Elongation factor 1 F54H5.2 F54H5.2 Protein containing a protein kinase domain, has low similarity to casein kinase I (S. cerevisiae Yck1p) F54H5.3 F54H5.3 Protein containing a major sperm protein (MSP) domain, which are involved in sperm motility vesicle-associated membrane protein/synaptobrevin binding protein (weak) F54H5.4 mua-1;F54H5.4 Putative DNA-binding protein involved in muscle cell attachment; contains a C2H2-type zinc finger domain; strongly similar to human and D. melanogaster BTEB2 proteins (basic transcription element binding protein 2, GC-box binding factors) Zinc finger; mua-1 encodes predicted transcription factor and xKLF homolog that affects cell matrix attachments that are critical for transmission of muscle contractions to the cuticle and for attachment of the uterus to the body wall, such that mutations result in paralysis of movement and prolapse of the uterus through the vulval opening, and many other secondary defects; its putative activation domain modestly activates transcription in COS cells and mua-1 expression is dynamic during development and includes the hypodermis, anterior pharynx, uv1, uv2, uv3, and utse cells of the uterus, and in the hypodermal nuclei bordering the seam. F54H5.5 F54H5.5 Protein of unknown function, has strong similarity to C. elegans D1081.5 F55A11.1 F55A11.1 Protein with weak similarity to H. sapiens Hs.159525 (Human cell growth regulator CGR11 mRNA, complete cds) EF hand domains F55A11.2 syn-3;F55A11.2 Member of the syntaxin family of vesicle transport receptors, has moderate similarity to syntaxin 5a (rat Stx5a), which is involved in vesicle docking and fusion in the Golgi apparatus epimorphin protein F55A11.3 F55A11.3 Protein containing a C3HC4 type (RING) zinc finger, has a region of weak similarity to a region of autocrine motility factor receptor (mouse Amfr), which is a cell surface glycoprotein involved in cell motility signaling and metastasis Zinc finger, C3HC4 type (RING finger) F55A11.4 F55A11.4 Member of the mitochondrial carrier (MCF) protein family, has similarity to H. sapiens MCF family member Aralar which binds calcium nucleotide translocator F55A11.5 F55A11.5 Member of the phospholipid and glycerol acyltransferase family, which are involved in phospholipid biosynthesis 1-acyl-glycerol-3-phosphate acyltransferase F55A11.6 F55A11.6 Protein containing a glutathione S-transferase C-terminal domain, which may be involved in conjugation of reduced glutathione to various targets glutathione S-transferase F55A11.7 F55A11.7 Protein of unknown function, has low similarity to uncharacterized C. elegans F55G1.6 F55A11.8 F55A11.8 Protein of unknown function F55A12.1 F55A12.1 Piwi-related protein with similarity over the C-terminal region to human and D. melanogaster PIWI proteins and C. elegans PRG-1 and PRG-2, all of which are involved in germ-line proliferation F55A12.10 F55A12.10 Protein with moderate similarity to C. elegans D1081.9 gene product F55A12.2 F55A12.2 Protein of unknown function F55A12.3 F55A12.3 Putative phosphatidylinositol-4-phosphate 5-kinase, has strong similarity to human PIP5K1A protein (phosphatidylinositol-4-phosphate 5-kinase, type I, alpha) F55A12.4 F55A12.4 Putative retinol dehydrogenase, has strong similarity to human RODH-4 protein (microsomal NAD+-dependent retinol dehydrogenase) dehydrogenase; dhs-2 encodes a short-chain dehydrogenase predicted to be mitochondrial. F55A12.5 F55A12.5 Protein of unknown function, has weak similarity to C. elegans Y2C2_202.B F55A12.6 F55A12.6 Protein of unknown function, has moderate similarity to uncharacterized C. elegans F48C1.8 F55A12.7 apm-1;F55A12.7 Member of the clathrin-associated protein family; RNA interference leads to 100% L1 larval stage lethality clathrin coat assembly protein complex 1 medium chain; The apm-1 gene encodes an adaptin: specifically, it encodes an ortholog of the mu1-II subunit of adaptor protein complex 1 (AP-1). F55A12.8 F55A12.8 Putative ortholog of S. cerevisiae Ynl132p, an essential protein of unknown function F55A12.9 F55A12.9 Putative ortholog of C. elegans F55A12.9 gene product The protein product of this gene is predicted to contain a glutamine/asparagine (Q/N)-rich ('prion') domain, by the algorithm of Michelitsch and Weissman (as of the WS77 release of WormBase, i.e., in wormpep77). F55A3.1 F55A3.1 Protein of unknown function, has a region of weak similarity to a region of S. cerevisiae Ssm4p, which is an E3 ubiquitin ligase of the endoplasmic reticulum that is involved in the S. cerevisiae Ubc6p-Ubc7p pathway of S. cerevisiae Alpha2p degradation F55A3.2 F55A3.2 Protein containing a C2H2 type zinc finger domain, which bind nucleic acids F55A3.3 F55A3.3 Protein with high similarity to facilitates chromatin transcription (chromatin-specific transcription elongation factor 140 kDa subunit, human FACTP140), which facilitates transcription elongation as a heterodimer with SSRP1 and binds nucleosomes transcritpion factor F55A3.5 F55A3.5 Protein of unknown function, has a region of moderate similarity to a region of glutathione peroxidase 4 (phospholipid hydroperoxide glutathione peroxidase, rat Gpx4), which is a selenoprotein that prevents peroxidation of membrane phospholipids glutathione peroxidase F55A3.6 F55A3.6 Member of the nucleoside diphosphate kinase family, which are involved in CTP, GTP and UTP biosynthesis, has a region of high similarity to a region of nucleoside diphosphate kinase B (human NME2), which is a transcription factor and endodeoxyribonuclease nucleoside diphosphate kinase F55A3.7 F55A3.7 Protein of unknown function, has low similarity to a region of facilitates chromatin transcription (chromatin-specific transcription elongation factor 140 kDa subunit, human FACTP140), which mediates transcription elongation as a heterodimer with SSRP1 transcritpion factor F55A4.1 F55A4.1 Protein with high similarity to SEC22 vesicle trafficking protein-like 1 (mouse Sec22l1), which may function in vesicle docking or fusion during transport between the endoplasmic reticulum and the Golgi apparatus, member of the synaptobrevin family vesicle trafficking protein sec22b F55A4.10 F55A4.10 Putative ortholog of C. elegans C09E10.1 gene product F55A4.2 F55A4.2 Protein of unknown function F55A4.3 F55A4.3 Protein of unknown function F55A4.4 F55A4.4 Protein containing a double-stranded RNA binding domain, has a region of low similarity to a region of staufen (mouse Stau1), which binds dsRNA, RNA-DNA hybrids, and tubulin and may help target RNA to the rough endoplasmic reticulum F55A4.5 F55A4.5 Protein containing four double-stranded RNA binding domains, has low similarity to staufen (human STAU), which binds dsRNA, RNA-DNA hybrids, telomerase RNA, and tubulin, may help target RNA to the rough endoplasmic reticulum and help in RNP assembly F55A4.6 F55A4.6 Member of the reverse transcriptase protein family, which are RNA-dependent DNA polymerases, has high similarity to uncharacterized C. elegans C49D10.1 F55A4.7 F55A4.7 Protein containing a calponin family repeat, which consist of a well conserved 26 amino acid domain F55A4.8 F55A4.8 Protein of unknown function, has a region of weak similarity to solute carrier family 18 A2 (vesicular monoamine transporter 2, human SLC18A2), which pumps monoamines and neurotransmitters into synaptic vesicles F55A8.1 egl-18;elt-5;F55A8.1 Protein containing a GATA-type zinc finger domain, has moderate similarity to C. elegans ELT-6, which is involved in epidermal differentiation zinc finger protein; egl-18 encodes a member of the GATA-family of transcription factors that affects cell migration, cell fate specification; expressed in the head, in hypodermal seam cells, VC neurons, and vulval precursor cells. F55A8.2 F55A8.2 Serine/threonine protein kinase, putative ortholog of human cGMP-dependent protein kinases PRKG1 and PRKG2 and of D. melanogaster cGMP-dependent protein kinase PKG21D cyclic-GMP-dependent protein kinase; The egl-4 gene encodes a cyclic GMP-dependant protein kinase that may act through the TGF-beta signalling pathway relay sensory cues that modulate chemosensory behavior, dauer formation, foraging and egg-laying. F55B11.1 F55B11.1 Protein with high similarity to xanthine dehydrogenase (human XDH), which acts in purine catabolism, contains a-b hammerhead, [2Fe-2S] binding, 2Fe-2S iron-sulfur cluster binding, molybdopterin binding, and dehydrogenase or oxidase FAD binding domains xanthine dehydrogenase; The F55B11.1 gene encodes an ortholog of the human gene XANTHINE DEHYDROGENASE (XDH), which when mutated leads to xanthinuria (OMIM:278300). F55B11.2 F55B11.2 Protein of unknown function, has similarity to human KIAA0170 protein (isolated from KG-1 cell line cDNA library), has weak similarity to C. elegans F55B11.2 F55B11.3 F55B11.3 Protein of unknown function, has a region of low similarity to a region of protein phosphatase 1 regulatory 5 (rat Egp), which is a targeting protein that stimulates glycogen biosynthesis and interacts with PP1, phosphorylase kinase and phosphorylase A F55B11.4 F55B11.4 Protein of unknown function F55B12.1 ceh-24;F55B12.1 Homeodomain transcription factor expressed in various nerve and muscle cells, mutant has no visible phenotype, has similarity over the homeodomain to many human and D. melanogaster homeodomain transcription factors homeobox protein (NK-2 subfamily); ceh-24 is orthologous to the human gene SIMILAR TO THYROID TRANSCRIPTION FACTOR 1 (TITF1; OMIM:600635), which when mutated leads to disease. F55B12.2 F55B12.2 Protein of unknown function, has high similarity to uncharacterized C. elegans C54F6.3 F55B12.3 sel-10;F55B12.3 Protein containing an F-box which negatively influences LIN-12 signaling; binds the presenilin homolog SEL-12 Candida CDC4 protein like; sel-10 encodes two isoforms of an F-box and WD-repeat-containing protein that is a member of the CDC4/CUL-1 family of E2-E3 ubiquitin ligases that target cell cycle control proteins for ubiquitin-mediated degradation; SEL-10 functions as a negative regulator of the LIN-12/Notch-like signaling pathway in C. elegans and thus may contribute to cell fate decisions mediated by LIN-12; SEL-10 physically interacts with LIN-12 and with SEL-12, a C. elegans presenilin, and as such, is proposed to regulate the levels and/or activity of these proteins; SEL-10 also plays a role in sexual fate determination by regulating sexually dimorphic apoptosis of hermaphrodite- and male-specific neurons; the targets of SEL-10 in these sex-specific fate decisions are not yet known. F55B12.4 F55B12.4 Member of the poly A polymerase family, which are nucleic acid independent RNA polymerases, has moderate similarity to uncharacterized human MtCCA poly(A) polymerase like; This gene encodes a protein predicted by Eisenberg and coworkers, with 52% accuracy, to be mitochondrial. F55B12.5 F55B12.5 Protein with weak similarity to H. sapiens BPI (bactericidal/permeability-increasing protein) F55B12.6 F55B12.6 Member of the 7-transmembrane chemoreceptor family of G protein-coupled receptors (GPCR), has low similarity to C. elegans ODR-10, which is involved in odorant response 7TM receptor F55B12.7 F55B12.7 Putative ortholog of C. elegans F09F3.12 gene product 7TM receptor, srx family F55B12.8 F55B12.8 Member of the rhodopsin family of G protein-coupled receptors (GPCR), has high similarity to uncharacterized C. elegans C47A10.8 F55C10.1 F55C10.1 Protein containing four EF hand domains, has a region of high similarity to calcineurin B (rat Ppp3r1), which is a calcium binding regulatory subunit of the calcium-calmodulin-dependent phosphatase calcineurin that functions in calcium-dependent signaling calcineurin B; cnb-1 encodes an ortholog of calcineurin B, the regulatory subunit of the protein phosphatase 2B with four EF-hand motifs for calcium binding, that binds TAX-6 (a calcineurin A ortholog) in a calcium-dependent manner; CNB-1 binds calcium, enhances the phosphatase activity of TAX-6 in vitro, promotes transcription of rcn-1, and is required for normal cuticle formation, sperm morphology, and brood size. F55C10.2 F55C10.2 Protein with high similarity to C. elegans DPY-16, which is a collagen that functions in morphogenesis of epithelium, contains two collagen triple helix repeats and one nematode cuticle collagen N-terminal domain collagen F55C10.3 F55C10.3 Protein with high similarity to C. elegans DPY-16, which is a collagen involved in epithelium morphogenesis, contains two collagen triple helix repeats, which are found in some extracellular proteins collagen F55C10.4 F55C10.4 Protein containing a DUF23 domain of unknown function, has high similarity to uncharacterized C. elegans F22F7.4 F55C12.1 F55C12.1 Possible coiled-coil protein of unknown function, has similarity to D. melanogaster NUF (nuclear fallout, regulates cortical microfilament organization) and human KIAA0665 protein, isolated from a brain cDNA library F55C12.2 F55C12.2 Protein of unknown function, has weak similarity to C. elegans R13H9.5 F55C12.4 F55C12.4 Protein of unknown function F55C12.5 F55C12.5 Protein of unknown function F55C12.6 F55C12.6 Protein of unknown function, has low similarity to uncharacterized C. elegans C28D4.8 F55C12.7 F55C12.7 Protein with weak similarity to C. elegans F55C12.3 gene product F55C5.1 F55C5.1 Protein containing a major sperm protein (MSP) domain, which are involved in sperm motility, has strong similarity to uncharacterized C. elegans ZC168.6 F55C5.2 F55C5.2 Protein of unknown function, has strong similarity to C. elegans T12B3.B, has weak similarity to glycerophosphoryldiester phosphodiesterases glycerophosphoryldiester phophodiesterase like F55C5.3 twk-11;F55C5.3 Member of the ion transport family, which include calcium, sodium, and potassium channels, has a region of weak similarity to a region of TASK-1 (rat Kcnk3), which forms an openly rectifying, weakly voltage-sensitive channel potassium channel protein F55C5.4 F55C5.4 Protein of unknown function F55C5.5 EF-Ts;F55C5.5 Member of the translation elongation factor TS family, contains a UBA (ubiquitin associated) or TS-N domain, has low similarity to uncharacterized TS translation elongation factor (mitochondrial, human TSFM) mitochondrial elongation factor TS; F55C5.5 encodes a translational elongation factor Ts (EF-Ts) that binds two different EF-Tu proteins (EF-TU1/Y71H2AM.23 and EF-TU2/C43E11.4) in vitro, stimulating guanine-nucleotide exchange and mRNA translation; F55C5.5 is predicted to be mitochondrial and has a putative N-terminal transit peptide sequence; F55C5.5 is required in mass RNAi assays for normally rapid growth and for maintenance of the germline. F55C5.6 F55C5.6 Member of the flavin containing amine oxidase family, has moderate similarity to uncharacterized C. elegans F25C8.2 amine oxidase like F55C5.7 F55C5.7 Protein containing two protein kinase domains, has weak similarity to uncharacterized human MGC11287 serine/threonine kinase F55C5.8 F55C5.8 Protein of unknown function, has low similarity to uncharacterized signal recognition particle 68kD (human SRP68), which is a putative component of the signal recognition particle complex involved in targeting nascent proteins to the ER signal recognition particle 68 KD protein F55C5.9 F55C5.9 Putatative G protein-coupled receptor with distant similarity to ODR-10 G-protein coupled receptor, srh family F55C7.2 F55C7.2 Protein of unknown function F55C7.7 unc-73;F55C7.7 Guanine nucleotide exchange factor required for axon guidance and directed cell migrations; acts in helping cells and axons to determine or interpret cellular polarity and functions in multiple aspects of axonogenesis and in sex myoblast migration guanine nucleotide exchange factor; The unc-73 gene encodes a guanine nucleotide exchange factor (GNEF) similar to the Trio protein; UNC-73 is required for vulval morphogenesis, for the migration of QL, QR, and hypodermal P cells, the commisure outgrowth of D type motoneurons, and amphid axon outgrowth; UNC-73 has GNEF activity for both CED-10 and MIG-2 in vitro; the requirement for UNC-73 in P cell migration can be suppressed by transgenic overexpression of rho-1; UNC-73 activates several small GTPases: RHO-1 in P cell migration, and both CED-10 and MIG-2 in vulval morphogenesis, P cell migration, and axon outgrowth. F55C9.1 F55C9.1 Protein containing an F-box domain, which serve as a link between a target protein and a ubiquitin-conjugating enzyme, has moderate similarity to uncharacterized C. elegans T26H2.2 This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins. F55C9.10 F55C9.10 Protein containing an F-box domain, which serve as a link between a target protein and a ubiquitin-conjugating enzyme, has high similarity to uncharacterized C. elegans F55C9.8 This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins. F55C9.11 F55C9.11 Protein containing an F-box domain, which serve as a link between a target protein and a ubiquitin-conjugating enzyme This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins. F55C9.2 F55C9.2 Protein of unknown function F55C9.3 F55C9.3 Protein containing a PAZ (Piwi, Argonaut and Zwille) domain, which may mediate protein-protein interactions F55C9.4 F55C9.4 Protein containing an F-box domain, which serve as a link between a target protein and a ubiquitin-conjugating enzyme, has low similarity to uncharacterized C. elegans F55C9.8 This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins. F55C9.5 F55C9.5 Protein of unknown function F55C9.6 F55C9.6 Protein containing a DUF141 domain of unknown function, has high similarity to uncharacterized C. elegans K08D8.6 F55C9.7 F55C9.7 Protein containing two F-box domains, which serve as a link between a target protein and a ubiquitin-conjugating enzyme, has weak similarity to uncharacterized C. elegans Y20C6A.2 This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins. F55C9.8 F55C9.8 Protein containing an F-box domain, which serve as a link between a target protein and a ubiquitin-conjugating enzyme, has high similarity to uncharacterized C. elegans F55C9.9 This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins. F55C9.9 F55C9.9 Protein containing an F-box domain, which serve as a link between a target protein and a ubiquitin-conjugating enzyme, has high similarity to uncharacterized C. elegans F55C9.8 F55D1.1 F55D1.1 Protein of unknown function F55D1.2 F55D1.2 Protein of unknown function F55D10.1 F55D10.1 Member of the glycosyl hydrolase family 38 of alpha-mannosidases, which are involved in carbohydrate metabolism, has moderate similarity to mannosidase 2 alpha B1 (mouse Man2b1), which catalyzes the hydrolysis of alpha-mannoside linkages Alpha-mannosidase; F55D10.1 is orthologous to the human gene MANNOSIDASE, ALPHA, CLASS 2B, MEMBER 1 (MAN2B1; OMIM:248500), which when mutated leads to disease. F55D10.2 F55D10.2 Protein with high similarity to C. elegans F52B5.6, which is involved in embryogenesis and morphogenesis, member of the ribosomal L23 family, which are part of the large ribosomal subunit Ribosomal protein L23; rpl-25.1 encodes a large ribosomal subunit L23a protein. F55D10.3 F55D10.3 Putative esterase, possible ortholog of D. melanogaster GLI (Gliotactin) Esterase F55D10.4 F55D10.4 Member of the rhodopsin family of G protein-coupled receptors (GPCR) olfactory receptor-like protein (weak) F55D10.5 F55D10.5 Protein containing neurotransmitter-gated ion-channel ligand binding and transmembrane domains, has moderate similarity to C. elegans MOD-1, which is a serotonin-gated chloride channel Ligand-gated ionic channel F55D12.1 F55D12.1 Protein of unknown function F55D12.2 F55D12.2 Putative coiled-coil protein, has weak similarity to human MYH3, a myosin heavy chain polypeptide F55D12.3 F55D12.3 Protein containing a nuclear hormone receptor C4-type zinc finger domain, which bind DNA and may be involved in regulation of transcription, and a nuclear hormone receptor ligand-binding domain, has low similarity to C. elegans NHR-51 Zinc finger, C4 type (two domains) F55D12.4 unc-55;F55D12.4 Nuclear hormone receptor involved in synaptic patterning nuclear hormone receptor F55D12.5 F55D12.5 Protein containing an activin type I or II receptor domain, which are found in the extracellular region of some growth factor receptors Activin types I and II receptor domain F55D12.6 F55D12.6 Protein of unknown function F55E10.1 F55E10.1 Protein of unknown function, has weak similarity to C. elegans F55E10.5 F55E10.2 F55E10.2 Protein of unknown function F55E10.3 F55E10.3 Protein of unknown function F55E10.4 F55E10.4 Protein of unknown function F55E10.5 F55E10.5 Protein of unknown function, has weak similarity to C. elegans F55E10.1 F55E10.6 F55E10.6 Putative retinol dehydrogenase, has strong similarity to human RODH-4 protein (microsomal NAD+-dependent retinol dehydrogenase) D-beta-hydroxybutyrate dehydrogenase (BDH); This gene encodes a protein predicted by Eisenberg and coworkers, with 52% accuracy, to be mitochondrial. F55E10.7 F55E10.7 Member of the rhodopsin family of G protein-coupled receptors (GPCR), has low similarity to somatostatin receptor 2 (human SSTR2), which inhibits adenylyl cyclase and mediates the inhibition of cell proliferation and secretion of pituitary hormones F55F1.1 F55F1.1 Protein with similarity to human huntingtin-associated protein interacting protein HAPIP, possibly involved in vesicle trafficking and ras-related signaling F55F1.2 F55F1.2 Protein of unknown function F55F1.3 F55F1.3 Protein of unknown function F55F10.1 F55F10.1 Protein of unknown function F55F10.2 F55F10.2 Putative ortholog of S. cerevisiae Ylr106p, a protein of unknown function F55F3.1 F55F3.1 Protein with high similarity to AMP-activated protein kinase beta 2 non-catalytic subunit (human PRKAB2), which is an AMP-activated protein kinase F55F3.2 F55F3.2 Member of the carboxylesterase protein family Carboxylesterases F55F3.3 F55F3.3 Protein with high similarity to C. elegans C17E4.9, which plays roles in gametogenesis and embryogenesis and morphogenesis, member of the Na+,K+ ATPase beta subunit family, which regulate the number of sodium pumps transported to the plasma membrane Sodium and potassium ATPases F55F3.4 F55F3.4 Protein of unknown function F55F8.1 ptr-10;F55F8.1 Member of the patched family, which are transmembrane receptors, has weak similarity to a region of Niemann-Pick disease type C1 (human NPC1), which is a lysosomal protein that plays a role cholesterol transport ptr-10 encodes a member of the Patched superfamily. F55F8.2 F55F8.2 Member of the DEAD or DEAH box ATP-dependent RNA helicase family and contains a helicase conserved C-terminal domain, has low similarity to S. cerevisiae Mak5p, which is involved in maintenance of M double-stranded RNA (dsRNA) killer plasmid RNA helicase F55F8.3 F55F8.3 Member of the WD repeat protein family F55F8.4 F55F8.4 Protein with similarity to hCIR, a human transcriptional repressor F55F8.5 F55F8.5 Protein containing six WD domains (WD-40 repeat), which may mediate protein-protein interactions, has a region of weak similarity to a region of C. albicans TUP1, which is a transcriptional repressor of genes involved in filamentous growth F55F8.6 F55F8.6 Protein of unknown function, has weak similarity to C. elegans F11C1.2 F55F8.7 F55F8.7 Member of the protein-tyrosine phosphatase family, which are involved in control of cell growth, proliferation, and differentiation, has a region of moderate similarity to a region of human PTPN3, which is a non-receptor protein tyrosine phosphatase protein-tyrosine phosphatase F55F8.8 F55F8.8 Protein of unknown function F55F8.9 F55F8.9 Member of the ZIP zinc transporter family, which may be metal transporters, has low similarity to uncharacterized C. elegans F30B5.7 F55G1.1 F55G1.1 Protein of unknown function F55G1.10 F55G1.10 Member of the histone H2A protein family Histone; his-61 encodes an H2A histone. F55G1.11 F55G1.11 Member of the histone H4 protein family Histone; his-60 encodes an H4 histone; by homology, HIS-60 is predicted to function as a nucleosome component required for packaging of DNA into chromatin; his-60 expression is detected in early embryos, beginning at the 28-cell stage and continuing through the comma stage (early morphogenesis); his-60 is a replication-dependent histone locus that resides in a histone gene-rich region on chromosome IV. F55G1.12 F55G1.12 Member of the amiloride-sensitive sodium channel family, which are involved in sodium reabsorption, has low similarity to a region of C. elegans UNC-8, which is an amiloride-sensitive sodium channel F55G1.13 F55G1.13 Protein containing eight epidermal growth factor (EGF)-like domains, has weak similarity to C. elegans SPE-9, which is a transmembrane protein found in sperm and required for spermatogenesis F55G1.14 F55G1.14 Protein of unknown function F55G1.15 F55G1.15 Protein of unknown function F55G1.17 F55G1.17 Protein of unknown function F55G1.2 F55G1.2 Member of the histone H3 protein family Histone; his-59 encodes an H3 histone; by homology, HIS-59 is predicted to function as a nucleosome component required for packaging of DNA into chromatin; his-59 is a replication-dependent histone locus that resides in a histone gene-rich region on chromosome IV. F55G1.3 F55G1.3 Member of the histone H2B protein family Histone; his-62 encodes an H2B histone. F55G1.4 F55G1.4 Protein of unknown function, has moderate similarity to H. sapiens Hs.115778 gene product F55G1.5 F55G1.5 Member of the mitochondrial carrier protein family of membrane transporters, has low similarity to 2-oxodicarboxylate transporter (S. cerevisiae ODC1), which is a transporter with specificity for 2-oxoadipate and 2-oxoglutarate carrier protein F55G1.6 F55G1.6 Protein of unknown function, has moderate similarity to C. elegans F55A11.7 F55G1.7 F55G1.7 Protein of unknown function F55G1.8 plk-2;plc-2;plc2;F55G1.8 Serine/threonine protein kinase with strong similarity to Drosophila POLO, human PLK, yeast Cdc5p, and other members of the polo family, which are involved in activation of the anaphase-promoting complex in late mitosis protein kinase F55G1.9 F55G1.9 Member of the delta 1-pyrroline-5-carboxylate reductase (P5CR) family, which are involved in proline biosynthesis, has low similarity to pyrroline-5-carboxylate reductase 1 (human PYCR1), which catalyzes reduction of pyrroline-5-carboxylate to proline carboxylate reductase F55G11.1 F55G11.1 Protein with strong similarity to C. elegans F14D7.4 gene product F55G11.10 F55G11.10 Protein with moderate similarity to C. elegans F28B1.5 gene product F55G11.2 F55G11.2 Protein containing a DUF141 domain of unknown function, has high similarity to uncharacterized C. elegans F55G11.4 F55G11.3 F55G11.3 Protein containing a DUF141 domain of unknown function, has high similarity to uncharacterized C. elegans F55G11.2 F55G11.4 F55G11.4 Member of an uncharacterized protein family F55G11.5 F55G11.5 Member of an uncharacterized protein family F55G11.6 F55G11.6 Member of an uncharacterized protein family F55G11.7 F55G11.7 Member of an uncharacterized protein family F55G11.8 F55G11.8 Member of an uncharacterized protein family F55G11.9 F55G11.9 Member of the ABC transporter family, which are involved in translocation of a variety of compounds across biological membranes, has low similarity to C. elegans CED-7 ABC transporters (2 domains) F55G7.1 F55G7.1 Protein of unknown function F55G7.2 F55G7.2 Protein of unknown function, has a region of low similarity to a region of S. cerevisiae Dot1p, which is involved in silencing at telomeres and other repressed loci and in the meiotic arrest checkpoint F55G7.3 F55G7.3 Protein of unknown function F55H12.1 F55H12.1 Member of the sodium:neurotransmitter symporter family, has low similarity to solute carrier family 6 member 5 (human SLC6A5), which is a sodium and chloride-dependent glycine transporter that may function in synaptic transmission Na(+)/Cl(-)-dependent betain transporter F55H12.2 F55H12.2 Member of the protein-tyrosine phosphatase family, which are involved in control of cell growth, proliferation, differentiation and transformation F55H12.3 F55H12.3 Protein containing nine epidermal growth factor-like, three sushi or short consensus repeat, low-density lipoprotein receptor class A, C-type lectin, and hyalin repeat domains, has a region of weak similarity to a region of mouse Notch2 LDL receptor F55H12.4 F55H12.4 Protein of unknown function, has weak similarity to C. elegans Y105C5.G F55H2.1 sod-4;F55H2.1 Cu/Zn superoxide dismutase Superoxide dismutase F55H2.2 F55H2.2 Protein with high similarity to vacuolar H(+)-ATPase (V-ATPase) subunit of the V1 catalytic sector (subunit D) (S. cerevisiae Vma8p), member of the ATP synthase subunit D family, which may constitute an integral portion of the V-ATPase catalytic sector Membrane-associated atpase gamma chain F55H2.3 F55H2.3 Putative ortholog of C. elegans let-99 gene product F55H2.4 F55H2.4 Protein containing a domain of unknown function, which are found in dishevelled, Egl-10, and Pleckstrin proteins, has high similarity to a region of C. elegans LET-99, which may act to establish embryonic polarity F55H2.5 F55H2.5 Protein of unknown function, has moderate similarity to uncharacterized cytochrome b-561 (human CYB561) Cytochrome B561 F55H2.6 clu-1;F55H2.6 Protein with weak similarity to translation initiation factor eIF3 p135 subunit (S. cerevisiae Clu1p) clu-1 encodes an ortholog of CLU1/TIF31 in S. cerevisiae, which directs proper cytoplasmic distribution of mitochondria and physically interacts with eukaryotic translation initiation factor 3 (eIF3); worm CLU-1 may be required for the proper distribution of mitochondria, but is dispensable for viability and gross morphology in mass RNAi screens. F55H2.7 F55H2.7 Protein of unknown function F55H2.7 encodes an unfamiliar protein that is dispensable for viability and gross morphology in mass RNAi screens; it residues in a common operon with clu-1, and thus might act in concert with it. F56A11.1 gex-2;F56A11.1 Protein with high similarity to cytoplasmic FMRP interacting protein 1 (CYFIPI, human KIAA0068), which binds F-actin and active GTP-bound human RAC1 and may function in membrane ruffling formation and in neuronal structure development or maintenance The gex-2 gene encodes a homolog of p140/Sra-1, a mammalian protein ligand of the small GTPase Rac1; gex-2 is required for tissue morphogenesis and cell migrations. F56A11.3 efn-4;F56A11.3 Member of the ephrin family, which are ligands of class V receptor protein-tyrosine kinases, has a region of low similarity to a region of ephrin-A1 (rat Efna1), which is a ligand of Eph-related receptor tyrosine kinases efn-4 encodes a member of the ephrin family of ligands that affects neuroblast migrations during closure of the ventral gastrulation cleft and subsequent epidermal morphogenesis, possibly functioning independently of EFN-1, EFN-2, EFN-3, and the VAB-1 receptor during morphogenesis; can interact with VAB-1 in vitro, and is expressed in neural and epidermal precursors at the 100-cell stage, in head neurons, pharyngeal cells, lateral and tail neurons, and in the ectoderm during epidermal enclosure. F56A11.4 F56A11.4 G protein-coupled receptor of unknown function, no homolog found in human or D. melanogaster F56A11.5 F56A11.5 Protein of unknown function, has high similarity to uncharacterized C. elegans F22B8.7 F56A11.6 F56A11.6 Protein of unknown function F56A12.1 ceh-35;F56A12.1 Protein with low similarity to sine oculis homeobox homolog 1 (human SIX1), which is a putative transcription factor that is hyperphosphorylated in mitosis and plays a role in cell cycle checkpoint and possibly muscle development and tumor progression so class homeobox protein; unc-39 encodes a Six-class homeodomain transcription factor homologous to Drosophila sine oculis and mammalian Six5 (OMIM:600963, associated with myotonic dystrophy type I (DMI)); UNC-39 is required for axonal pathfinding in anterior-derived neurons and for specification of most mesodermal cell types, and may regulate a developmental decision between migration and differentiation; UNC-39 is expressed in the embryo in anterior neurons, posteriorly derived mesoderm (somatic gonad, M mesoblast, and possibly the coelomocytes and muIntR), the CAN neurons, and body wall muscle. F56A12.2 F56A12.2 Protein of unknown function, has moderate similarity to uncharacterized C. elegans M04G7.3 F56A3.1 F56A3.1 Protein of unknown function F56A3.2 F56A3.2 Protein of unknown function F56A3.3 F56A3.3 Protein of unknown function npp-6 encodes a protein with weak similarity to mouse nuclear pore complex protein Nup160, and affects embryonic and larval viability. F56A3.4 F56A3.4 Putative coiled-coil protein, has weak similarity to S. cerevisiae Uso1p, required for protein transport from ER to Golgi F56A3.5 F56A3.5 Protein of unknown function F56A4.1 F56A4.1 Putative paralog of C. elegans K06A4.1 metalloprotease F56A4.11 F56A4.11 Putative paralog of C. elegans F56A4.12 F56A4.12 F56A4.12 Putative paralog of C. elegans F56A4.11 F56A4.2 F15E11.9;F56A4.2 Member of the C-type lectin family F56A4.3 F56A4.3 Protein with strong similarity to C. elegans Y45G12C.2 F56A4.4 F56A4.4 Putative paralog of C. elegans Y45G12C.L F56A4.5 F56A4.5 Putative paralog of C. elegans Y45G12C.4 F56A4.6 F56A4.6 Protein of unknown function, putative paralog of C. elegans Y45G12C.11 F56A4.7 F56A4.7 Protein of unknown function, putative paralog of C. elegans Y45G12C.12 7TM chemoreceptor, str family F56A4.8 F56A4.8 Putative paralog of C. elegans Y95B8A.3 transposase F56A4.9 F56A4.9 Protein of unknown function, has strong similarity to C. elegans Y19D10B.C F56A4.H Y45G12C.3;F56A4.H Protein containing a glutathione S-transferase N-terminal domain, has very strong similarity to uncharacterized C. elegans F56A4.4 F56A6.2 hum-7;F56A6.2 Putative myosin heavy chain myosin; hum-7 encodes a class IX unconventional myosin heavy chain that contains a myosin motor domain in the head region and zinc-finger and rhoGAP (rho GTPase activating protein) domains in the tail region; HUM-7 is required during embryogenesis for cytokinesis and normal cytoplasmic rearrangements, and by homology, may function in organization of the actin cytoskeleton; the precise expression and localization patterns of HUM-7 are not yet known. F56A6.3 F56A6.3 Member of the Tc3 Transposase protein family transposase F56A6.4 F56A6.4 Protein of unknown function F56A8.1 F56A8.1 Protein of unknown function, has weak similarity to uncharacterized human C11orf25 F56A8.2 F56A8.2 Protein containing three leucine rich repeats, which mediate protein-protein interactions, has a region of moderate similarity to a region of C. elegans LET-413, which plays a critical role in the process of organizing and positioning adherens junctions F56A8.3 F56A8.3 Protein containing three leucine rich repeats, which mediate protein-protein interactions, has a region of moderate similarity to a region of C. elegans LET-413, which plays a critical role in organizing and positioning adherens junctions Leucine Rich Repeat (2 copies) (2 domains) F56A8.4 F56A8.4 Protein containing an F-box domain, which serve as a link between a target protein and a ubiquitin-conjugating enzyme, has low similarity to uncharacterized C. elegans F56A8.5 F56A8.5 F56A8.5 Protein containing an F-box domain, which serve as a link between a target protein and a ubiquitin-conjugating enzyme, has low similarity to uncharacterized C. elegans F56A8.4 This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins. F56A8.6 F56A8.6 Putative RNA-binding protein; strongly similar to human CSTF2 protein (subunit 2 of cleavage stimulation factor); possibly involved in SL2-specific trans-splicing RNA recognition motif. (aka RRM, RBD, or RNP domain) F56A8.7 unc-64;F56A8.7 Protein with similarity to D. melanogaster and human syntaxin Syntaxin; unc-64 encodes syntaxin, an plasma membrane receptor for intracellular vesicles that is orthologous to vertebrate syntaxin 1A (OMIM:186590) and Drosophila Syx1A; UNC-64 is required for normal locomotion and possibly also for insulin secretion; as an essential component of the core synaptic vesicle fusion machinery, UNC-64 interacts with UNC-13, a diacylglycerol-binding protein, and SNB-1/synaptobrevin; UNC-64 protein levels are reduced in an unc-18 mutant background; unc-64 mutations can be suppressed by mutations in slo-1, a calcium-activated potassium channel; UNC-64 is expressed ubiquitously in the nervous system and in secretory cells such as the uv1 cell in the vulva and excretory gland cells. F56A8.8 F56A8.8 Protein of unknown function F56B3.1 F56B3.1 Protein containing two collagen triple helix repeats, which are found in some extracellular proteins, and one nematode cuticle collagen N-terminal domain, has a region of high similarity to a region of C. elegans BLI-1, which is involved in chemotaxis F56B3.10 F56B3.10 Protein containing glutathione S-transferase N-terminal and C-terminal domains, has low similarity to prostaglandin D2 synthase (human PGDS), which is a prostaglandin D synthase and glutathione S-transferase that regulates non-rapid eye movement sleep glutathione S-transferase F56B3.11 F56B3.11 Protein of unknown function F56B3.12 F56B3.12 Putative ortholog of C. elegans skr-17 gene product F56B3.2 F56B3.2 Protein containing two EB module domains, has weak similarity to a region of tenascin C (hexabrachion, human TNC), which may be involved in cell adhesion and neurite outgrowth F56B3.3 F56B3.3 Protein of unknown function, has moderate similarity to C. elegans F58D12.1 F56B3.4 F56B3.4 Member of the Skp1 family, which are required for targeted protein degradation during the cell cycle skr-18 encodes a homolog of Skp1 in S. cerevisiae, a core component of the SCF (Skp1p, Cullin, F-box) ubiquitin-ligase complex that facilitates ubiquitin-mediated protein degradation; SKR-18 has no known function in vivo, since skr-18(RNAi) animals are at least superficially normal. F56B3.5 F56B3.5 Protein with high similarity to AU-specific RNA binding enoyl-CoA hydratase (human AUH), which binds to the AU-rich regions in the 3' untranslated region of lymphokine and some proto-oncogene mRNAs, member of the enoyl-CoA hydratase or isomerase family F56B3.6 F56B3.6 Member of the TB2 or DP1 and HVA22 related protein family, has a region of moderate similarity to a region of S. cerevisiae Yop1p, which acts together with Yip1p in membrane trafficking F56B3.7 F56B3.7 Protein containing a UDP-glucoronosyl and UDP-glucosyl transferase domain, has low similarity to UDP-glucuronosyltransferase (rat Udpgtr-2), which is a liver enzyme that glucuronidates testosterone, 4-hydroxybiphenyl and chloramphenicol UDP-glucuronosyltransferase F56B3.8 F56B3.8 Member of the ribosomal L2 family, which are part of the large ribosomal subunit, has low similarity to uncharacterized mouse Mrpl2 F56B3.9 F56B3.9 Protein containing three C2H2 type zinc finger domains, which bind nucleic acids F56B6.2 rgs-7;C2-RGS;F56B6.2 Protein containing three regulator of G protein signaling domains, has a region of moderate similarity to a region of regulator of G protein signaling 3 (human RGS3), which stimulates the GTPase activity of G protein alpha subunits helix-loop-helix phosphoprotein F56B6.4 uvt-5;F56B6.4 Member of the glycosyl transferase family 8, has moderate similarity to glycogenin 2 (human GYG2), which acts in the transfer of glucose from UDP-glucose in a self-glucosylation reaction and is involved in the initiation phase of glycogen synthesis glycogenin F56B6.5 uvt-6;F56B6.5 Member of the rhodopsin family of G protein-coupled receptors (GPCR), has low similarity to somatostatin receptor 5 (rat Sstr5), which suppresses adenylyl cyclase and mediates the inhibition of cell proliferation and secretion of pituitary growth hormone G-protein coupled receptor; uvt-6 encodes a G protein-coupled receptor that is most similar to the mammalian somatostatin receptors; uvt-6 was first identified in molecular analyses of gene products linked to the vitellogenin (vit) loci on the X chromosome; as loss of uvt-6 activity via large-scale RNAi screens does not result in any obvious abnormalities, the precise role of uvt-6 in C. elegans development and/or behavior is not yet known; uvt-6 mRNA is expressed weakly in adult hermaphrodites. F56B6.6 F56B6.6 Protein of unknown function F56C11.1 F56C11.1 Protein with similarity to NAD(P)H oxidases and weak similarity to S. cerevisiae ferric reductases, paralog of C. elegans F53G12.3 bli-3 encodes a large homolog of dual oxidase ('Ce-Duox1'), with an N-terminal peroxidase domain, two central calmodulin-binding EF hands, and a C-terminal superoxide-generating NADPH-oxidase domain; BLI-3 is required for dityrosine cross-linking of collagen, and thus for cuticular integrity; BLI-3 is thought to use cytosolic NADPH to generate reactive oxygen, which then drives the peroxidase ectodomain to cross-link free tyrosine in collagen; BLI-3 is expressed exclusively in hypodermal cells at low levels, with peaks of expression corresponding to collagen/cuticle biosynthesis. F56C11.2 ptr-11;F56C11.2 Member of the patched family, which are transmembrane receptors, has a region of weak similarity to a region of C. elegans PTC-1, which is involved in patterning during development F56C11.3 F56C11.3 Protein of unknown function, has a region of high similarity to augmenter of liver regeneration (rat Gfer), which is a flavin-linked sulfhydryl oxidase involved in liver regeneration that catalyzes disulfide bond formation in reduced protein substrates F56C11.5 F56C11.5 Protein of unknown function, has weak similarity to C. elegans C05E11.3 F56C11.6 F56C11.6 Member of the carboxylesterase protein family carboxylesterases F56C3.1 F56C3.1 Protein of unknown function, has weak similarity to C. elegans H25K10.2 F56C3.2 F56C3.2 Member of an uncharacterized protein family This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins; this gene's encoded protein also contains an FTH/DUF38 motif, which may also mediate protein-protein interaction. F56C3.3 F56C3.3 Protein of unknown function F56C3.4 F56C3.4 Protein of unknown function F56C3.5 F56C3.5 Protein of unknown function F56C3.6 F56C3.6 Protein with strong similarity to C. elegans dgn-1 gene product F56C3.7 F56C3.7 Protein of unknown function F56C3.8 F56C3.8 Protein of unknown function F56C3.9 F56C3.9 Protein of unknown function, has high similarity to uncharacterized C. elegans F47B10.9 F56C4.1 F56C4.1 Protein of unknown function F56C4.2 F56C4.2 Protein of unknown function F56C9.1 CeGLC-7b;F56C9.1 PP1-gamma serine/threonine protein phosphatase F56C9.10 F56C9.10 Protein of unknown function, has weak similarity to S. cerevisiae Yfr021p F56C9.11 F56C9.11 Protein of unknown function F56C9.2 F56C9.2 Member of the reverse transcriptase protein family, which are RNA-dependent DNA polymerases, has strong similarity to uncharacterized C. elegans Y76B12C.5 F56C9.3 F56C9.3 Member of the cation efflux family, which may be membrane divalent cation transporters, has high similarity to uncharacterized C. elegans R02F11.3 F56C9.5 F56C9.5 Protein containing an acyl CoA binding domain F56C9.6 F56C9.6 Protein of unknown function F56C9.7 F56C9.7 Protein of unknown function, has low similarity to uncharacterized C. elegans T20D3.2 F56C9.8 F56C9.8 Protein of unknown function F56C9.9 F56C9.9 Protein of unknown function F56D1.1 F56D1.1 Protein containing five C2H2 type zinc finger domains, which bind nucleic acids, has weak similarity to a region of KRAB zinc finger protein (mouse Mzf22), which functions as a transcriptional repressor Zinc finger protein F56D1.2 F56D1.2 Protein of unknown function F56D1.3 F56D1.3 Possible small ribosomal subunit protein This gene encodes a protein predicted by Eisenberg and coworkers, with 52% accuracy, to be mitochondrial. F56D1.4 clr-1;F56D1.4 Type II receptor tyrosine phosphatase and putative member of Ig superfamily; negatively regulates EGL-15 signaling protein-tyrosine-phosphatase; A receptor tyrosine phosphatase that negatively regulates the FGF receptorsignaling pathway; it localizes to the plasma membrane. F56D1.5 daz-1;F56D1.5 Meiotic factor required for oogenesis dhs-5 encodes a possible steroid dehydrogenase; DHS-5 generally resembles short chain-type alcohol/other dehydrogenases, but has two predicted N-terminal transmembrane sequences, and its closest relatives in vertebrates are known or putative steroid dehydrogenases such as hydroxysteroid (17-beta) dehydrogenase 12 from mouse (also known as KIK-I or DHBK_MOUSE). F56D1.6 F56D1.6 Protein containing three EF hand domains, which are found in signaling, buffering or transport proteins, has low similarity to uncharacterized C. elegans T09A5.1, which is a putative calcium-binding protein calcium binding protein (weak) F56D12.1 F56D12.1 Protein with similarity to aldehyde dehydrogenases aldehyde dehydrogenase; alh-6 is orthologous to the human gene ALDEHYDE DEHYDROGENASE 4 FAMILY, MEMBER A1 (ALDH4A1; OMIM:606811), which when mutated leads to hyperprolinemia type II. F56D12.2 F56D12.2 Protein of unknown function F56D12.3 F56D12.3 Protein of unknown function F56D12.4 F56D12.4 Protein of unknown function JIP-1 is partly similar to the human gene ISLET-BRAIN 1 (MAPK8IP1; OMIM:604641), which when mutated leads to type II diabetes. F56D12.5 F56D12.5 May function in a double strand break DNA repair pathway F56D12.6 F56D12.6 Protein of unknown function F56D2.1 F56D2.1 Member of the insulinase (peptidase M16) family, which are divalent cation-dependent, has moderate similarity to mitochondrial processing peptidase beta subunit (rat Pmpcb), which acts as a metalloendopeptidase that cleaves mitochondrial precursors Mitochondrial processing protease enhancing protein; This gene encodes a protein predicted by Eisenberg and coworkers, with 52% accuracy, to be mitochondrial. F56D2.2 F56D2.2 Protein containing an IBR (In Between Ring Fingers) domain, has low similarity to ring finger protein 14 (human RNF14), which is a transcriptional coactivator that associates with human AR F56D2.3 F56D2.3 Protein of unknown function F56D2.4 F56D2.4 Member of the ubiquitin-conjugating enzyme (E2) family, which catalyze the covalent attachment of ubiquitin to target proteins, has low similarity to ubiquitin-conjugating enzyme E2 (C. albicans Rad6p), which is involved in DNA repair uev-2 encodes a ubiquitin-conjugating enzyme (UBC or E2) variant that contains the characteristic UBC motif, but lacks the critical active-site cysteine residue necessary for catalytic activity; as loss of UEV-2 function via RNA-mediated interference (RNAi) does not result in any abnormalities, the precise role of UEV-2 in C. elegans development and/or behavior is not yet known; based on similarity to Saccharomyces cerevisiae and human proteins, however, UEV-2 may play a role in cell cycle control or response to stress or DNA damage. F56D2.5 F56D2.5 Putative paralog of C. elegans F56D2.2, has similarity to a region of human retinoic acid inducible RING finger protein Hs.9899, has a TRIAD composite zinc finger domain F56D2.6 F56D2.6 Protein with high similarity to S. cerevisiae Prp43p, which is a pre-mRNA splicing factor, contains a helicase conserved C-terminal domain The F56D2.6 gene encodes a DEAH helicase orthologous to the Drosophila CG11107, the human DDX15, and the S. cerevisiae PRP43 proteins. F56D2.7 ced-6;F56D2.7 Protein containing a phosphotyrosine interaction domain (PTB or PID), which bind activated tyrosine-phosphorylated receptors, has a region of moderate similarity to human CED-6, which is an adaptor protein involved in apoptotic cell phagocytosis ced-6 encodes an Src homology (SH) 3 and phosphotyrosine-binding (PTB) domain-containing adaptor protein, orthologous to human CED-6/GULP, that is required for cell corpse engulfment during apoptosis; CED-6 is bound by the phosphotyrosine binding motif in the cytoplasmic tail of the transmembrane protein CED-1, and and within phagocytic cells this interaction may be part of a signal transduction pathway that promotes apoptotic cell engulfment. F56D2.8 F56D2.8 Protein of unknown function F56D3.1 F56D3.1 Protein of unknown function, has weak similarity to C. elegans F33E2.6 F56D5.1 F56D5.1 Protein containing one nematode cuticle collagen N-terminal domain and collagen triple helix repeats, which are found in some extracellular proteins, has moderate similarity to C. elegans DPY-7, which is a cuticle collagen collagen F56D5.10 F56D5.10 Protein of unknown function, has high similarity to uncharacterized C. elegans W07A8.1 F56D5.2 F56D5.2 Protein of unknown function F56D5.3 F56D5.3 Member of the NADH:flavin oxidoreductase or NADH oxidase family, which reduce a range of alternative electron acceptors, has a region of low similarity to a region of NADPH dehydrogenase isoform 2 (old yellow enzyme isoform 2, S. cerevisiae Oye2p) NADH oxidase F56D5.4 F56D5.4 Protein with strong similarity to C. elegans C45E1.4 gene product F56D5.5 F56D5.5 Protein of unknown function, has high similarity to uncharacterized C. elegans Y38E10A.3 F56D5.6 F56D5.6 Protein with weak similarity to S. cerevisiae UBP1 (Ubiquitin-specific protease (ubiquitin C-terminal hydrolase), cleaves at the C-terminus of ubiquitin) F56D5.7 F56D5.7 Member of the transposase family, which are required for excising and inserting mobile genetic elements, has very strong similarity to uncharacterized C. elegans C31A11.2 transposase F56D5.9 F56D5.9 Protein containing two BRCA1 (breast cancer type 1) C terminus (BRCT) domains, which are found in some cell cycle checkpoint proteins and two ankyrin (Ank) repeats, has high similarity to uncharacterized C. elegans C06G3.4 ankyrin repeats F56D6.1 F56D6.1 Protein containing a C-type lectin domain, which mediate calcium-dependent carbohydrate recognition, has low similarity to uncharacterized C. elegans F46A8.2 F56D6.2 F56D6.2 Protein containing a C-type lectin domain, which mediate calcium-dependent carbohydrate recognition, has high similarity to uncharacterized C. elegans Y46C8AL.5 F56D6.4 F56D6.4 Member of an uncharacterized protein family 7TM chemoreceptor, srz family F56D6.5 F56D6.5 Member of an uncharacterized protein family 7TM chemoreceptor, srz family F56D6.6 F56D6.6 Protein of unknown function, has weak similarity to C. elegans D2062.7 7TM chemoreceptor, srz family F56E10.1 F56E10.1 Protein of unknown function F56E10.2 F56E10.2 Protein containing a formin homology 2 domain, which are found in proteins that control rearrangements of the actin cytoskeleton, has a region of low similarity to a region of dishevelled associated activator of morphogenesis 1 (human DAAM1) F56E10.3 F56E10.3 Protein of unknown function F56E10.4 F56E10.4 Protein with high similarity to ribosomal protein S27 (metallopanstimulin-1, human RPS27), which is a small 40S ribosomal subunit protein and putative transcription regulator associated with breast cancer, member of the ribosomal S27 family ribosomal protein; rps-27 encodes a small ribosomal subunit S27 protein. F56E3.3 klp-4;F56E3.3 Protein with high similarity to kinesin family member 13a (mouse Kif13a), which functions as a plus end-directed microtubule-dependent motor protein and is involved in controlling intracellular vesicle transport, contains two kinesin motor domains kinesin-related protein; klp-4 encodes a kinesin-like motor protein paralogous to UNC-104 and KLP-6 and orthologous to Drosophila KHC-73 and the vertebrate KIF1A, KIF13B, and GAKIN motor proteins; as loss of KLP-4 function via RNA-mediated interference (RNAi) does not result in any abnormalities, the precise role of KLP-4 in C. elegans development and/or behavior is not yet known; based on sequence similarity, however, KLP-4 is predicted to play a role in neuronal development or function; in situ hybridization results suggest that klp-4 is expressed in the nervous system. F56E3.4 fax-1;F56E3.4 Putative nuclear hormone receptor involved in axon fasciculation nuclear hormone receptor; fax-1 encodes a predicted nuclear hormone receptor that contains two C4-type zinc fingers; FAX-1 is orthologous to the vertebrate photoreceptor-specific nuclear receptor (NR2E3 or PNR; OMIM:604485, mutated in enhanced S-cone syndrome and retinitis pigmentosa); FAX-1 is required for normal locomotion and for specification of neuronal identities, including pathfinding of the AVKR, AVKL, HSNL, and PVQL axons and expresion of the FMRFamide-like FLP-1 peptide neurotransmitter in AVKR and AVKL; FAX-1 is expressed in embryonic neurons, including the AVK interneurons, just prior to axon extension. F56F10.1 F56F10.1 Protein with low similarity to prolylcarboxypeptidase (angiotensinase C, human PRCP), which is a serine carboxypeptidase that catalyzes the cleavage of C-terminal amino acid residues linked to proline and may be associated with essential hypertension peptidase F56F10.2 F56F10.2 Protein containing an F-box domain, which serve as a link between a target protein and a ubiquitin-conjugating enzyme F56F10.3 F56F10.3 Protein with high similarity to cysteine dioxygenase 1 (rat Cdo1), which catalyzes the conversion of cysteine to 3-sulfinoalanine in cysteine catabolism cytenine dioxygenase F56F10.4 F56F10.4 Protein with weak similarity to lethal giant larvae (Drosophila) homolog 1 (human LLGL1), which is a cytoskeletal protein that associates with the heavy chain of nonmuscle myosin II F56F11.1 F56F11.1 Protein of unknown function F56F11.2 F56F11.2 Protein of unknown function F56F11.3 F56F11.3 Protein containing a C2H2-type zinc finger domain, has strong similarity over the C-terminus to human and D. melanogaster BTEB2 proteins (basic transcription element binding protein 2, GC-box binding factors) and human Kruppel-like zinc finger transcription factors zinc finger protein F56F11.4 F56F11.4 Member of the proteasome complex protein family 26S protease regulatory subunit F56F11.5 F56F11.5 Protein of unknown function, has high similarity to uncharacterized C. elegans Y38C1AB.6 F56F12.1 F56F12.1 Protein of unknown function F56F3.1 F56F3.1 Protein of unknown function The protein product of this gene is predicted to contain a glutamine/asparagine (Q/N)-rich ('prion') domain, by the algorithm of Michelitsch and Weissman (as of the WS77 release of WormBase, i.e., in wormpep77). F56F3.2 ndg-4;F56F3.2 Protein predicted to span a membrane twelve times, member of a family of C. elegans and D. melanogaster proteins F56F3.3 F56F3.3 Protein of unknown function F56F3.4 F56F3.4 Member of the ubiquitin family, contains an AN1-like zinc finger domain Ubiquitin family F56F3.5 F56F3.5 Member of the ribosomal protein S1 protein family Ribosomal protein S3a (human) homolog.; rps-1 encodes a small ribosomal subunit S3A protein. F56F3.6 ins-17;Ceinsulin-2;F56F3.6 Insulin-like protein of the type-gamma subfamily F56F4.1 F56F4.1 Member of the transthyretin-like family F56F4.2 F56F4.2 Member of the transthyretin-like family, has weak similarity to uncharacterized C. elegans T08A9.2 F56F4.3 F56F4.3 Protein with low similarity to solute carrier family 6 (neurotransmitter transporter, GABA) member 1 (human SLC6A1), which is a high affinity sodium and chloride-dependent GABA transporter that plays an important role in GABAergic neurotransmission F56F4.4 F56F4.4 Protein of unknown function F56F4.5 F56F4.5;opt3 Proton channel and proton-dependent oligopeptide transporter protein oligopeptide transporter F56F4.6 F56F4.6 Member of the ABC transporter family, which are involved in translocation of a variety of compounds across biological membranes, has moderate similarity to a region of C. elegans CED-7 F56F4.7 F56F4.7 Protein of unknown function, has weak similarity to C. elegans C06G3.12 F56G4.1 F56G4.1 Protein containing two DUF33 domains of unknown function, has low similarity to uncharacterized C. elegans T26H2.7 F56G4.2 pes-2;F56G4.2 Protein containing an F-box domain, which serve as a link between a target protein and a ubiquitin-conjugating enzyme, has very strong similarity to uncharacterized C. elegans F56G4.3 pes-2 encodes a protein containing a predicted signal sequence and an F-box, a motif believed to mediate protein-protein interactions either with homologs of yeast Skp1p or with other proteins; pes-2 was identified in two different molecular screens, a promoter-trapping screen and a screen for genes that are preferentially transcribed in pre-gastrulation embryos; by homology, pes-2 is predicted to function in ubiquitin-proteasome mediated protein degradation; pes-2 may also play a role in lifespan determination, as its expression is downregulated in young adult worms containing loss-of-function mutations in the daf-2 insulin/IGF-1 receptor, and loss of pes-2 function via RNA-mediated interference (RNAi) can enhance animal survival rates; pes-2 expression is first detected in 4- to 8-cell stage embryos, continues in early embryogenesis in cells from the AB, MS, and E founder cell lineages, and in later embryogenesis is becomes restricted to hypodermal cells; expression in larvae and adults has not yet been reported. F56G4.3 F56G4.3;pes-2 Protein containing an F-box domain, which serve as a link between a target protein and a ubiquitin-conjugating enzyme, has very strong similarity to C. elegans PES-2 F56G4.4 F56G4.4 Protein of unknown function, has weak similarity to human formin binding protein 21 ( Hs.28307) F56G4.5 F56G4.5 Member of the transglutaminase-like superfamily and the thioredoxin family, has a region of moderate similarity to peptide:N-glycanase (S. cerevisiae Png1p), which is an enzyme that may be involved in degradation of misfolded glycoproteins Thioredoxins; This gene encodes a protein predicted by Eisenberg and coworkers, with 52% accuracy, to be mitochondrial. F56G4.6 F56G4.6 Protein of unknown function F56H1.1 che-14;ptd-1;F56H1.1 Required for normal chemotaxis towards water-soluble chemicals as well as secretory processes in the hypodermis and the amphid support cells che-14 encodes a protein with a sterol-sensing domain; CHE-14 protein is involved in the exocytotic secretion of lipid-modified proteins at the apical surface of certain epithelial cells. F56H1.2 F56H1.2 Protein containing a WSN domain of unknown function zinc finger protein F56H1.3 F56H1.3 Protein containing one BRCA1 (breast cancer type 1) C terminus (BRCT) domain, which are found in some cell cycle checkpoint proteins and one WSN domain of unknown function, has low similarity to uncharacterized C. elegans F26D2.10 F56H1.4 rpt-5;F56H1.4 Putative ATPase subunit of 19S proteasome particle ATPase; rpt-5 encodes a triple A ATPase subunit of the 26S proteasome's 19S regulatory particle (RP) base subcomplex; RPT-5 is required for embryonic, larval, and germline development and by homology, is predicted to function in unfolding protein substrates and translocating them into the core proteolytic particle (CP) of the proteasome. F56H1.5 F56H1.5 Protein with strong similarity to C. elegans EEED8.6 gene product F56H11.1 F56H11.1 Putative ortholog of C. elegans fbl-1 gene product fibrulin-1D; fbl-1 encodes, through alternative splicing, at least three proteins orthologous to the vertebrate basement membrane protein fibulin; fbl-1 is is dispensable for viability and gross morphology in mass RNAi assays. F56H11.2 F56H11.2 Protein of unknown function F56H11.3 F56H11.3 Member of the GNS1 or SUR4 family of integral membrane proteins, has moderate similarity to polyunsaturated fatty acid (PUFA) elongase (C. elegans CEEl01), which contains the condensation activity required for fatty acid elongation Yeast GNS1 like; The elo-7 gene encodes a paralog of elo-1 and elo-2, each of which encodes a polyunsaturated fatty acid (PUFA) elongase; ELO-7 has no known function in vivo. F56H11.4 ceel01;F56H11.4 Polyunsaturated fatty acid (PUFA) elongase; contains the condensation activity required for fatty acid elongation, with a preference for delta6-desaturated (n-6 or n-3) C18 polyunsaturated fatty acids Yeast YJT6 like; elo-1 encodes a component of C-18 polyunsaturated fatty acid (PUFA) elongase that is required for normal elongation of n-6 and n-3 20-carbon PUFA in vivo; ELO-1 is a condensing enzyme that elongates n-6 and n-7 (and, with less efficiency, n-3) series C18 PUFAs. F56H11.6 F56H11.6 Protein of unknown function, has low similarity to uncharacterized C. elegans C49C8.1 casein kinase F56H6.1 F56H6.1 Member of the galactosyltransferase family, which transfer galactose to GlcNAc termini of growing oligosaccharide chains, has high similarity to uncharacterized C. elegans C02H6.1 F56H6.11 F56H6.11 Protein containing a DUF33 domain of unknown function, has high similarity to uncharacterized C. elegans F56H6.12 F56H6.12 F56H6.12 Protein containing a DUF33 domain of unknown function, has high similarity to uncharacterized C. elegans F56H6.11 F56H6.13 F56H6.13 Putative ortholog of C. elegans F40C5.1 gene product F56H6.2 F56H6.2 Protein of unknown function, has high similarity to uncharacterized C. elegans W08G11.1 F56H6.3 F56H6.3 Protein with moderate similarity to C. elegans F11D11.10 gene product F56H6.4 F56H6.4 Protein of unknown function, has high similarity to uncharacterized C. elegans F49D11.3 F56H6.5 F56H6.5 Protein with high similarity to GDP-mannose-4,6-dehydratase (human GMDS), which is an epimerase that converts GDP-mannose to GDP-mannose-4-keto-6-D-deoxymannose and is defective in leukocyte adhesion deficiency type II (LADII) probable GDP-mannose 4,6-dehydratase F56H6.6 F56H6.6 Protein of unknown function, has high similarity to uncharacterized C. elegans C54C8.2 F56H6.7 F56H6.7 Protein of unknown function, has high similarity to uncharacterized C. elegans F56H6.9 F56H6.8 F56H6.8 Member of the C-type lectin protein family CUB domain, Lectin C-type domain short and long forms (2 domains) F56H6.9 F56H6.9 Protein of unknown function, has high similarity to uncharacterized C. elegans F56H6.7 F56H9.1 F56H9.1 Protein containing two DUF225 domains of unknown function, has a region of low similarity to a region of podocalyxin like (human PODXL), which is a transmembrane sialomucin that is an L selectin ligand and important for lymphocyte adhesion and homing 7TM receptor, srx family F56H9.2 F56H9.2 Protein of unknown function F56H9.3 gpa-8;F56H9.3 Member of the G protein alpha subunit family guanine nucleotide-binding protein; gpa-8 encodes a member of the G protein alpha subunit family of heterotrimeric GTPases; expressed in URX, AQR, and PQR sensory cells. F56H9.4 gpa-9;F56H9.4 Member of the G protein alpha subunit family guanine nucleotide-binding protein; gpa-9 encodes a member of the G protein alpha subunit family of heterotrimeric GTPases; it is expressed in ASJ, PHB, PVQ, pharyngeal muscle, and the spermatheca. F56H9.5 lin-25;F56H9.5 Putative target of MAP kinase cascade pathway; required for vulva development lin-25 F57A10.1 F57A10.1 Member of the 7-transmembrane chemoreceptor family of G protein-coupled receptors (GPCR), has weak similarity to C. elegans ODR-10, which is involved in odorant response F57A10.2 F57A10.2 Protein containing a major sperm protein (MSP) domain, which are involved in sperm motility, has moderate similarity to uncharacterized C. elegans F38H4.6 F57A10.3 F57A10.3 Member of the ABC transporter family, which are involved in translocation of a variety of compounds across biological membranes, contains an ABC transporter transmembrane domain, has moderate similarity to S. cerevisiae Mdl1p multidrug resistance protein (p-glycoprotein); haf-3 encodes a member of the ABC transporter family with highest similarity to human ABCB10. F57A10.4 F57A10.4 Protein of unknown function F57A10.5 nhr-60;F57A10.5 Member of the nuclear hormone receptor/Zinc finger protein family Ligand-binding domain of nuclear hormone receptors, Zinc finger, C4 type (two domains) F57A8.1 F57A8.1 Protein of unknown function ETS domain F57A8.2 F57A8.2 Protein of unknown function, has moderate similarity to uncharacterized human 54TM F57A8.3 F57A8.3 Member of the 7-transmembrane chemoreceptor family of G protein-coupled receptors (GPCR), has low similarity to C. elegans ODR-10, which is involved in odorant response F57A8.4 F57A8.4 Protein of unknown function, has low similarity to uncharacterized C. elegans E04D5.2 7 transmembrane receptor (rhodopsin family) F57A8.5 F57A8.5 Member of the nuclear hormone receptor/Zinc finger protein family Zinc finger, C4 type (two domains) F57A8.6 F57A8.6 Protein containing a DX module domain F57A8.7 F57A8.7 Protein of unknown function, has moderate similarity to uncharacterized C. elegans F58G11.4 F57B1.1 F57B1.1 Protein with strong similarity to C. elegans T09E8.4 gene product F57B1.2 F57B1.2 Protein with weak similarity to C. elegans unc-84 (Protein required for nuclear migration and anchoring) F57B1.3 F57B1.3 Protein containing two collagen triple helix repeats and one nematode cuticle collagen N-terminal domain, has a region of high similarity to a region of collagen type V alpha 2 subunit (human COL5A2), which functions in connective tissue maintenance collagen F57B1.4 F57B1.4 Protein containing two collagen triple helix repeats and one nematode cuticle collagen N-terminal domain, has a region of moderate similarity to a region of collagen type V alpha 2 subunit (human COL5A2), which is involved in connective tissue maintenance collagen F57B1.5 F57B1.5 Protein of unknown function F57B1.6 F57B1.6 Protein of unknown function F57B1.7 F57B1.7 Protein of unknown function F57B10.1 F57B10.1 Protein containing a bZIP (basic-leucine zipper) transcription factor domain F57B10.10 dad-1;F57B10.10 Inhibitor of apoptosis with strong similarity (62% identity over 113 residues) to human DAD1 dad-1 encodes an ortholog of human DAD1 (OMIM:600243) that inhibits cell death and can functionally complement the hamster protein in cultured cells. F57B10.11 bag-1;F57B10.11 Member of the BAG-1-related family of proteins that regulate Hsp70/Hsc70 chaperone activity and, in humans, interact with nuclear hormone receptors A homolog of the human BAG-family of co-chaperone proteins, negatively regulates Hsp70 and affects cell stress and cell growth. F57B10.12 mei-2;F57B10.12 Involved in microtubule disassembly during meiotic spindle formation and the functional homolog of H. sapiens p60 katanin F57B10.3 F57B10.3 Protein with similarity to maize 2-3-bisphosphoglycerate-independent phosphoglycerate mutase phosphoglycerate mutase F57B10.4 F57B10.4 Putative coiled-coil protein, has weak similarity to human CENPE, centromere protein E F57B10.5 F57B10.5 Member of the p24 family of type I membrane proteins F57B10.6 F57B10.6 Protein containing a Xeroderma pigmentosum group G (XPG) N-terminal domain and an XPG I-region (Xeroderma pigmentosum group G internal region) domain, which function in DNA excision repair, has weak similarity to S. cerevisiae Rad2p DNA repair protein; F57B10.6 is orthologous to the human gene EXCISION REPAIR CROSS-COMPLEMENTING RODENT REPAIR DEFICIENCY, COMPLEMENTATION GROUP 5 (XERODERMA PIGMENTOSUM, COMPLEMENTATION GROUP G (COCKAYNE SYNDROME)) (ERCC5; OMIM:133530), which when mutated leads to disease. F57B10.7 F57B10.7 Member of the trehalase family, which are O-glycosyl hydrolases, has moderate similarity to trehalase (human TREH), which catalyzes the hydrolysis of the disaccharide trehalose to yield glucose and plays a role in digestion and metabolism of carbohydrates glycosyl hydrolase F57B10.8 F57B10.8 Protein with low similarity to activator of basal transcription 1 (mouse Abt1), which is a single- and double-stranded DNA binding protein that interacts with TATA-binding protein (Tbp) and functions as a basal transcriptional activator of class II genes F57B10.9 F57B10.9 Protein of unknown funciton F57B10.9 is orthologous to the human gene SPARTIN (TAHCCP1; OMIM:607111), which when mutated leads to disease. F57B7.1 F57B7.1 Member of the rhodopsin family of G protein-coupled receptors (GPCR), has low similarity to uncharacterized C. elegans D1069.4 G-protein coupled receptor F57B7.2 F57B7.2 Member of the SCP-like extracellular protein family SCP-like extracellular Proteins F57B7.3 F57B7.3 Protein containing two collagen triple helix repeats and one nematode cuticle collagen N-terminal domain, has high similarity to a region of C. elegans BLI-1, which is a putative collagen that functions in embryogenesis and morphogenesis and chemotaxis collagen F57B7.4 mig-17;F57B7.4 Secreted protein and a member of the metalloprotease-disintegrin family; it is likely required for the remodeling of the basement membrane for normal gonad distal tip cell migration zinc metallopeptidase (M12B family) F57B9.1 F57B9.1 Member of the pyridoxamine 5'-phosphate oxidase family, which are involved in biosynthesis of pyridoxine and derivatives, has moderate similarity to pyridoxine 5'-phosphate oxidase (rat U91561), which catalyzes the oxidation of pyridoxamine-5'-phosphate PNP/PMP oxidase F57B9.10 rpn-6;F57B9.10 Putative non-ATPase subunit of 19S proteasome particle rpn-6 is predicted to encode a non-ATPase subunit of the 19S regulatory complex of the proteasome that affects adult viability, larval viability, embryonic viability, fertility, and osmoregulation. F57B9.2 F57B9.2 Protein of unknown function, has a region of weak similarity to S. cerevisiae Cdc39p, which is a nuclear protein that negatively affects basal transcription from many promoters and is a member of the CCR4-Not complex F57B9.3 F57B9.3 Member of the RNA helicase, DEAD-box protein family Eukaryotic initiation factor 4A F57B9.4 F57B9.4 Member of the UbiA prenyltransferase family, which can prenylate proteins or small molecules, has moderate similarity to para-hydroxybenzoate--polyprenyltransferase mitochondrial precursor (S. pombe Ppt1p), which is involved in ubiquinone biosynthesis 4-hydroxybenzoate octaprenyltransferase; coq-2 encodes a para-hydroxybenzoate-polyprenyl transferase (UbiA prenyltransferase) whose yeast ortholog is mitochondrial. F57B9.5 F57B9.5 Protein with strong similarity to human bystin, which is involved in cell adhesion byn-1 encodes a homolog of mammalian BYSTIN-LIKE (BYSL; OMIM:603871). F57B9.6 inf-1;eIF-4A;F57B9.6 Putative eIF-4A RNA helicase inf-1 encodes a protein with high similarity to eukaryotic initiation factor 4A. F57B9.7 F57B9.7 Possible coiled-coil protein, has weak similarity to human to LRRFIP1, leucine rich repeat (in FLII) interacting protein 1 F57B9.8 F57B9.8 Protein containing a protein kinase domain and one Src homology 2 (SH2) domain, which are regulatory modules of intracellular signaling, has moderate similarity to fer (fps/fes related) tyrosine kinase (mouse Fert2), which may mediate cell-cell signaling putative protein tyrosine kinase F57B9.9 F57B9.9 Protein of unknown function The protein product of this gene is predicted to contain a glutamine/asparagine (Q/N)-rich ('prion') domain, by the algorithm of Michelitsch and Weissman (as of the WS77 release of WormBase, i.e., in wormpep77). F57C12.1 F57C12.1 Member of the astacin (M12A) family of metalloproteases, contains a CUB domain, has low similarity to C. elegans HCH-1, which is a putative zinc-dependent metalloprotease involved in cell migration and neurogenesis F57C12.2 F57C12.2 Protein of unknown function, has a region of low similarity to a region of S. cerevisiae Gtr1p, which is a GTP-binding protein involved in the function of the S. cerevisiae Pho84p phosphate transporter GTP-binding protein F57C12.3 F57C12.3 Protein of unknown function; member of the basic helix-loop-helix DNA-binding domain family helix-loop-helix DNA-binding proteinn F57C12.4 mrp-2;F57C12.4 Probable membrane transporter of the ATP-binding cassette (ABC) superfamily involved in heavy metal resistance, has strong similarity to human canalicular multispecific organic anion transporters CMOAT and CMOAT2 ATP-binding transport family; mrp-2 encodes a predicted multidomain transmembrane protein that is a member of the ATP-binding cassette (ABC) superfamily of transport proteins and is homologous to the human multidrug resistance-associated protein 1 (MRP1, OMIM:158343); by homology, MRP-2 is predicted to function as a membrane pump that couples the energy of ATP hydrolysis to membrane transport; as loss of MRP-2 function via RNA-mediated interference (RNAi) does not result in any abnormalities, the precise role of MRP-2 in C. elegans development and/or behavior is not yet known; mrp-2 expression is, however, upregulated early in the exit from the alternative dauer stage and then remains induced, suggesting that MRP-2 activity is required for the transition to, and maintenance of, a more active metabolic state. F57C12.5 mrp-1;F57C12.5 Protein of the ATP-binding cassette (ABC) superfamily involved in heavy metal tolerance, has strong similarity to human canalicular multispecific organic anion transporters ABC transporter F57C2.1 F57C2.1 Member of the BTB/POZ domain protein family F57C2.2 F57C2.2 Member of the BTB/POZ domain protein family BTB (also known as BR-C/Ttk) domain. F57C2.3 F57C2.3 Protein of unknown function, has high similarity to uncharacterized C. elegans 3R5.1 F57C2.4 F57C2.4 Protein of unknown function F57C2.5 F57C2.5 Member of the strictosidine synthase family, which catalyze the condensation of tryptamine with secologanin to form strictosidine, has low similarity to uncharacterized human C20ORF3 F57C2.6 F57C2.6 Protein of unknown function F57C7.1 F57C7.1 Protein containing several bromodomains, has strong similarity to human testis-specific bromodomain protein BRDT, has strong similarity to D. melanogaster female sterile homeotic protein FS(1)H, has moderate similarity to S. cerevisiae BDF1-like bromodomain proteins female sterile homeotic protein (Bromodomain protein) F57C7.2 F57C7.2 Member of the sodium or hydrogen exchanger family, which maintain the pH of actively metabolizing cells, has moderate similarity to human SLC9A7, which is a hydrogen-translocating V-type ATPase that mediates exchanges of calcium or sodium ions for protons Na(+)/H(+) exchanger; nhx-5 encodes a sodium/proton exchanger expressed intracellularly in many neurons, as well as in the vulC cells of the vulva and the excretory cell; nhx-5 has no obvious phenotype in mass RNAi screens; NHX-5 is thought to prevent intracellular acidification by catalysing the electroneutral exchange of vesicular sodium for an intracellular proton; the granular intracellular expression of NHX-5::GFP suggests association with some cytoplasmic organelle specifically required for neuronal function. F57C7.3 F57C7.3 Protein containing a syndecan domain, which are found in heparin sulfate proteoglycans that may bind extracellular matrix and growth factors syndecan like protein; sdn-1 encodes a homolog of vertebrate syndecan-2, a type I transmembrane heparan sulfate proteoglycan; by homology, SDN-1 is predicted to play a role in cell-cell and cell-matrix adhesion; loss of sdn-1 activity via RNA-mediated interference (RNAi) indicates that SDN-1 is required for backward locomotion and for normal development of the egg-laying system, particularly gonadal and vulval structures; SDN-1 is expressed in a subset of neuronal cell bodies and their associated processes in the nerve ring, and also in select tail neurons. F57C7.4 F57C7.4 Protein of unknown function F57C7.5 F57C7.5 Protein of unknown function F57C9.1 F57C9.1 Member of the PfkB family of carbohydrate kinases, has moderate similarity to pyridoxal kinase (vitamin B6 kinase, human PDXK), which catalyzes the phosphorylation of pyridoxal to form pyridoxal-5-phosphate in vitamin B6 metabolism F57C9.2 F57C9.2 Protein of unknown function F57C9.3 F57C9.3 Protein containing putative C2H2-type zinc finger domains, has weak similarity in the N-terminus to C2H2-type zinc finger domain proteins of human, D. melanogaster, C. elegans and S. cerevisiae F57C9.4 F57C9.4 Protein of unknown function, has strong similarity to C. elegans Y48A6B.8 F57C9.5 F57C9.5 Protein of unknown function F57C9.6 F57C9.6 Member of the rhodopsin family of G protein-coupled receptors (GPCR) F57C9.7 F57C9.7 Protein of unknown function F57E7.1 F57E7.1 Protein of unknown function, has high similarity to uncharacterized C. elegans F20A1.1 F57E7.2 F57E7.2 Protein with moderate similarity to C. elegans T08G3.11 gene product F57E7.3 F57E7.3 Member of the 7-transmembrane chemoreceptor family of G protein-coupled receptors (GPCR), has high similarity to uncharacterized C. elegans Y6E2A.6 F57F10.1 F57F10.1 Member of the bicarbonate (HCO3-) exchanger family of membrane transporters, has low similarity to human SLC4A1, which exchanges chloride and bicarbonate ions and plays a role in cell shape, size control and cytoskeletal anchoring Anion exchange protein; The F57F10.1 gene encodes two proteins, F57F10.1A and F57F10.1B that are homologous to the Arabidopsis and Saccharomyces boron exporters, BOR1 and YNL275w, and closely similar to the to the human BOR1/YNL275w ortholog, BTS1; like BOR1 and YNL275w, F57F10.1A/B proteins might act to export borate ions. F57F4.1 F57F4.1 Member of the cytosolic long-chain acyl-CoA thioester hydrolase family, has low similarity to mitochondrial acyl-CoA thioesterase of 48 kDa (mouse Mt-act48), which hydrolyzes the thioester bond of fatty acyl-CoA and releases free fatty acid F57F4.2 F57F4.2 Protein of unknown function F57F4.3 F57F4.3 Protein of unknown function, putative paralog of C. elegans F57F4.4 gfi-1 encodes a protein that contains 21 ET modules; interacts with unc-68 in yeast two-hybrid assays. F57F4.4 F57F4.4 Protein of unknown function, putative paralog of C. elegans F57F4.3 F57F5.1 F57F5.1 Protein with high similarity to cathepsin B (human CTSB), which is a cysteine (thiol) protease that degrades cartilage matrix proteins, the amyloid beta precursor protein (human APP), and other proteins, member of the papain family of cysteine proteases cysteine protease F57F5.2 gcy-33;F57F5.2 Putative soluble guanylyl cyclase expressed in the BAG sensory neurons guanylate cyclase F57F5.3 F57F5.3 Protein of unknown function F57F5.4 add-2;F57F5.4 Protein containing a Class II aldolase domain, has a region of high similarity to a region of alpha adducin (human ADD1), which may promote spectrin-actin complex assembly, regulate ion transport, and be associated with hypertension upon gene mutation adducin; add-2 encodes a protein containing an alpha-adducin-like head domain that while highly similar in sequence to the head domain of vertebrate and Drosophila adducins, atypically resides at the C-, rather than N-, terminus of the protein; by homology, ADD-2 is predicted to be a cell membrane-associated cytoskeletal protein that mediates cytoskeletal rearrangements in response to activation of signal transduction cascades; as loss of add-2 activity via large-scale RNAi screens does not result in any obvious abnormalities, the precise role of ADD-2 in C. elegans development and/or behavior is not yet known. F57F5.5 kin-13;F57F5.5;PKC1 Protein kinase C isoform, serine/threonine protein kinase with strong similarity to human, D. melanogaster, and S. cerevisiae protein kinase C isoforms Phorbol esters / diacylglycerol binding domain (2 domains), Protein kinase C terminal domain; pkc-1 encodes a serine/threonine protein kinase that is orthologous to mammalian protein kinase C epsilon (PRKCE), a member of the nPKC subgroup of the protein kinase C superfamily; together with UNC-13, PKC-1 may act downstream of goa-1 to modulate phorbol ester-induced stimulation of acetylcholine release at NMJs; PKC-1 positively regulates locomotion, and affects thermotaxis and chemotaxis together with kin-11; PKC-1 is required for regulating several behaviors including sensation of volatile and soluble compounds, osmolarity, and temperature (thermosensation); PKC-1 is also required for phorbolester-induced stimulation of acetylcholine release at neuromuscular junctions; PKC-1 localizes to the processes and cell bodies of approximately 75 sensory neurons and interneurons, and pkc-1 mRNA is detectable at varying levels during larval and adult stages. F57G12.1 F57G12.1 Protein of unknown function F57G12.2 F57G12.2 Protein of unknown function F57G4.1 F57G4.1 Protein containing two DUF38 domains of unknown function, has weak similarity to uncharacterized C. elegans Y6G8.2 F57G4.2 F57G4.2 Protein of unknown function, has high similarity to uncharacterized C. elegans F25G6.1 F57G4.3 F57G4.3 Protein of unknown function, has low similarity to uncharacterized C. elegans H20H17.1 F57G4.4 F57G4.4 Protein containing an F-box domain, which serve as a link between a target protein and a ubiquitin-conjugating enzyme, and a DUF38 domain of unknown function, has low similarity to C. elegans FOG-2, which is required for the sexual identity of germ cells This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins; this gene's encoded protein also contains an FTH/DUF38 motif, which may also mediate protein-protein interaction. F57G4.5 F57G4.5 Putative ortholog of C. elegans F57G4.7 gene product F57G4.6 F57G4.6 Protein of unknown function, putative paralog of C. elegans F57G4.7 F57G4.7 F57G4.7 Putative ortholog of C. elegans F57G4.6 gene product F57G4.8 F57G4.8 Protein containing an F-box domain, which serve as a link between a target protein and a ubiquitin-conjugating enzyme and a DUF38 domain of unknown function, has a region of low similarity to C. elegans FOG-2, which is required for germ cell identity This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins; this gene's encoded protein also contains an FTH/DUF38 motif, which may also mediate protein-protein interaction. F57G4.9 F57G4.9 Protein containing one transposase DDE domain F57G8.1 F57G8.1 Member of the 7-transmembrane chemoreceptor family of G protein-coupled receptors (GPCR), has high similarity to uncharacterized C. elegans ZK228.8 F57G8.2 F57G8.2 Protein of unknown function, has weak similarity to C. elegans F13A7.3 F57G8.3 F57G8.3 Member of the 7-transmembrane chemoreceptor family of G protein-coupled receptors (GPCR), has high similarity to uncharacterized C. elegans ZK228.7 F57G8.4 F57G8.4 Protein with strong similarity to C. elegans F18E3.5 gene product 7TM chemoreceptor, srw family F57G8.5 F57G8.5 Member of the sodium or hydrogen exchanger family, which maintain the pH of actively metabolizing cells, has high similarity to uncharacterized C. elegans F41E7.1 F57G8.6 F57G8.6 Putative paralog of C. elegans ZK488.2 Domain of unknown function F57G8.7 F57G8.7 Protein of unknown function, has weak similarity to C. elegans E04F6.9 F57G8.8 F57G8.8 Protein of unknown function, has weak similarity to C. elegans F13A7.4 F57G8.9 F57G8.9 Protein of unknown function F57G9.1 F57G9.1 Member of the C. elegans Sre G protein-coupled chemoreceptor family, which are putative chemosensory receptors, has high similarity to uncharacterized C. elegans F57G9.2 7TM receptor, sre family F57G9.2 F57G9.2 Member of the C. elegans Sre G protein-coupled chemoreceptor family, which are putative chemosensory receptors, has high similarity to uncharacterized C. elegans F57G9.1 7TM receptor, sre family F57G9.3 F57G9.3 Protein of unknown function, has strong similarity to C. elegans Y57A10C.1 F57G9.4 F57G9.4 Member of the C. elegans Sre G protein-coupled chemoreceptor family, which are putative chemosensory receptors, has high similarity to uncharacterized C. elegans W05H5.6 7TM receptor, sre family F57H12.1 arf-3;F57H12.1 Protein with strong similarity to ADP-ribosylation factor 5 (human ARF5), which stimulates cholera toxin ADP ribosyltransferase activity and plays a role in intracellular vesicular and membrane transport, member of the ADP-ribosylation factor (ARF) family GTP-binding protein; arf-3 encodes a member of the ADP-ribosylation factor related protein family; likely expressed in touch receptors and regulated by MEC-3. F57H12.2 unc-24;F57H12.2 Protein required for coordinated locomotion This gene encodes a protein predicted by Eisenberg and coworkers, with 52% accuracy, to be mitochondrial. F57H12.3 ora-1;F57H12.3 Protein containing a DUF148 domain of unknown function, has high similarity to uncharacterized C. elegans F57H12.6 F57H12.4 F57H12.4 Member of the rhodopsin family of G protein-coupled receptors (GPCR), has a region of weak similarity to a region of growth hormone secretagogue receptor (rat Ghsr), which binds ghrelin (rat LOC59301) and regulates growth hormone release seven trans-membrane receptor F57H12.5 F57H12.5 Member of the protein-tyrosine phosphatase family, which are involved in control of cell growth, proliferation, differentiation and transformation, has strong similarity to uncharacterized C. elegans C07E3.4 phosphatase F57H12.6 F57H12.6 Protein containing a DUF148 domain of unknown function, has high similarity to uncharacterized onchocerciasis-related antigen (C. elegans ORA-1), which is a putative receptor signaling protein F57H12.7 F57H12.7 Protein of unknown function, has weak similarity to C. elegans W06B11.1 F58A3.1 ldb-1;F58A3.1 Protein with strong similarity to H. sapiens LDB1 and D. melanogaster CHI (Chip) ldb-1 encodes an Ldb/NLI/Clim member of the nuclear LIM binding protein family that affects coordinated locomotion, vulval development, mechanosensation, and growth of larvae and is required for transcriptional activation of mec-2; can interact with MEC-3 to activate transcription using yeast two-hybrid assays and is expressed in all neurons, vulval cells, gonadal sheath cells, and in some body muscle cells. F58A3.2 egl-15;F58A3.2 Tyrosine protein kinase, member of fibroblast growth factor receptor (FGFR) and Ig superfamilies IG (immunoglobulin) superfamily (3 domains), protein tyrosine kinase (fibroblast growth factor subfamily); egl-15 encodes an FGF-like receptor tyrosine kinase orthologous to human FGFR1 (OMIM:136350, which when mutated leads to Pfeiffer syndrome); EGL-15 is required for several processes including fluid balance and sex myoblast migration, which is essential for proper development of the egg-laying system, and is required to phosphorylate SAX-7, which inhibits the colocalization of SAX-7 with the ankyrin UNC-44; EGL-15 activators may include the FGF-like signalling molecules EGL-17 and LET-756; negative regulators include CLR-1, a receptor protein-tyrosine phosphatase. F58A3.3 F58A3.3 Protein of unknown function F58A3.4 F58A3.4 Protein containing a major sperm protein (MSP) domain, which are involved in sperm motility, has moderate similarity to uncharacterized C. elegans T13F2.12 F58A3.5 F58A3.5 Member of the transthyretin-like family, has high similarity to uncharacterized C. elegans R90.2 Transthyretin-like family F58A4.1 F58A4.1 Protein of unknown function, has moderate similarity to uncharacterized C. elegans C48B4.12 F58A4.10 F58A4.10 Protein with high similarity to S. cerevisiae Ubc7p, which is a ubiquitin-conjugating enzyme, associates with S. cerevisiae Ubc6p on the cytoplasmic side of endoplasmic reticulum, member of the ubiquitin-conjugating enzyme (E2) family Ubiquitin conjugating enzyme F58A4.11 F58A4.11 Protein with weak similarity to C. elegans dpy-20 (Protein required for proper cuticle formation) gei-13 encodes a protein, with a BED finger domain (predicted to be DNA-binding) and a glutamine/asparagine-rich domain; GEI-13 physically interacts with GEX-3, and is required for normal body shape, cuticle synthesis, and locomotion. F58A4.2 F58A4.2 Protein of unknown function F58A4.3 hcp-3;F58A4.3 Centromeric histone-H3-like protein; required for chromosome segregation; putative ortholog of S. cerevisiae Cse4p and human CENP-A Histone H3 similarity; The hcp-3 gene encodes a centromere protein (CENP)-A homolog required for kinetochore function; inactivation of hcp-3 in one-cell embryos by RNAi causes a complete loss of kinetochores, with total failure of chromosomes to segregate properly during mitosis, to recruit components to the kinetochore other than HCP-3, or to assemble a stable mitotic spindle; in addition, HCP-4 fails to localize properly to the kinetochore in hcp-3(RNAi) embryos. F58A4.4 F58A4.4 Putative DNA polymerase alpha primase subunit D DNA primase 49Kd subunit; pri-1 encodes a homolog of the DNA polymerase alpha-primase subunit D that is required in embryos for the normal timing of embryonic cell divisions, much as DIV-1 is. F58A4.5 F58A4.5 Member of the lectin C-type domain protein family Reverse transcriptase F58A4.6 F58A4.6 Protein of unknown function F58A4.8 tbg-1;F58A4.8 Gamma tubulin Gamma-like tubulin F58A4.9 F58A4.9;AC19 Member of the RNA polymerases L / 13 To 16 Kd subunit protein family RNA Pol I/III 16Kd polypeptide F58A6.1 F58A6.1 Member of the enoyl-CoA hydratase or isomerase family, has low similarity to short chain enoyl-Coenzyme A hydratase 1 (rat Echs1), which catalyzes the hydration of trans-2-enoyl-CoA forming 3-hydroxyacyl-CoA in mitochondrial fatty acid beta-oxidation F58A6.10 F58A6.10 Member of the C. elegans Srb family of receptor-like integral membrane proteins, has high similarity to uncharacterized C. elegans SRB-1 7TM chemoreceptor, srb family F58A6.11 F58A6.11 Member of the C. elegans Srb family of receptor-like integral membrane proteins, has high similarity to uncharacterized C. elegans SRB-5 7TM chemoreceptor, srb family F58A6.2 F58A6.2 Protein of unknown function F58A6.4 F58A6.4 Member of the astacin (M12A) family of metalloproteases, contains a CUB domain, has moderate similarity to a region of C. elegans HCH-1, which is a putative zinc-dependent metalloprotease involved in cell migration and neurogenesis F58A6.5 F58A6.5 Protein with moderate similarity to C. elegans Y69E1A.1 gene product F58A6.6 F58A6.6 Member of the C. elegans Sre G protein-coupled chemoreceptor family, which are putative chemosensory receptors, has weak similarity to uncharacterized C. elegans F58A6.11 7TM chemoreceptor, srb family F58A6.8 msp-45;F58A6.8 Major sperm protein required for spermatogenesis in C. elegans major sperm protein; msp-45 encodes a member of the major sperm protein family. F58A6.9 F58A6.9 Protein of unknown function, has very strong similarity to a region of C. elegans MSP-10, which is involved in oocyte maturation major sperm protein F58B3.1 F58B3.1 Member of an uncharacterized protein family with similarity to Entemeba histolytica lysozymes F58B3.2 F58B3.2 Member of an uncharacterized protein family with similarity to Entemeba histolytica lysozymes F58B3.3 F58B3.3 Member of an uncharacterized protein family with similarity to Entemeba histolytica lysozymes lys-6 (lys=laterally symmetrical) encodes a microRNA, a small non-protein coding RNA and was the first miRNA to have a role in nervous system development in vivo; lys-6 is involved in the pathway for functional lateralization of the chemosensory ASE neuron; lys-6 controls the asymmetrical expression of the gcy chemoreceptors, gcy-5 and gcy-7, in ASER and ASEL; reporter gene fusions indicate that lys-6 is expressed in one pair of tail neurons and seven head neurons including ASEL, but not in ASER. F58B3.4 F58B3.4 Protein of unknown function, has low similarity to uncharacterized human C20orf6 F58B3.5 F58B3.5 Member of the class I isoleucyl, leucyl, valyl, and methionyl (I, L, M, and V) tRNA synthetase family, contains a putative tRNA binding domain, has a region of high similarity to methionine-tRNA synthetase (human MARS) methionyl-tRNA synthetase; mrs-1 encodes a predicted cytoplasmic methionyl-tRNA synthetase (MetRS), a class I aminoacyl-tRNA synthetase that catalyzes the attachment of methionine to its cognate tRNA and is thus required for protein biosynthesis; MRS-1 is essential for embryogenesis and required also for a normal rate of postembryonic growth. F58B3.6 F58B3.6 Protein with low similarity to interferon-related developmental regulator (rat Ifrd1), which plays a role in muscle differentiation and is induced by by viral infection, nerve growth factor, mitogens and by the tumor promoter tetradecanoyl phorbol acetate interferon-related protein PC4 like F58B3.7 F58B3.7 Protein containing an RNA recognition motif (RRM, RBD, or RNP) and a G-patch domain, which are found in RNA processing proteins, has low similarity to an uncharacterized human SPF45, which is a putative 45 kDa pre-mRNA splicing factor Arabidopsis DNA-damage-repair protein D11 like F58B3.8 F58B3.8 Protein containing a delta serrate ligand (DSL) domain, has a region of low similarity to a region of C. elegans LAG-2, which appears to interact with C. elegans LIN-12 and C. elegans GLP-1 Notch receptors to influence cell fate decisions EGF-like domain F58B3.9 F58B3.9 Member of the transthyretin-like family Transthyretin-like family F58B4.1 F58B4.1 Member of the astacin (M12A) family of metalloproteases, has a region of low similarity to a region of C. elegans HCH-1, which is a putative zinc-dependent metalloprotease zinc metalloprotease F58B4.2 F58B4.2 Protein containing a heme-binding domain cytochrome b5 like F58B4.3 F58B4.3 Protein of unknown function F58B4.4 F58B4.4 Protein of unknown function F58B4.5 F58B4.5 Member of an uncharacterized protein family F58B6.1 F58B6.1 Member of the lipase class 3 family, which are a subset of lipolytic enzymes that hydrolyze ester linkages of triglycerides, has high similarity to uncharacterized C. elegans T10B5.7 F58B6.2 F58B6.2 Protein containing a formin homology 2 domain, which are found in proteins that control rearrangements of the actin cytoskeleton, has a region of low similarity to a region of diaphanous homolog 1 (mouse Diap1), which induces focal contact formation F58B6.3 F58B6.3 Putative ortholog of C. elegans F58B6.3A gene product par-2 encodes a protein containing a C3HC4-type RING-finger, a specialized type of zinc-finger found in E3 ubiquitin ligase subunits; PAR-2 is required maternally for polarization of the C. elegans zygote along the anterior-posterior (A-P) axis and is asymmetrically localized to the posterior cortex of the one- and two-cell embryo via interdependent interactions with PAR-3, PAR-6, and PKC-3. F58D12.1 F58D12.1 Protein of unknown function, has strong similarity to uncharacterized C. elegans K08D10.11 F58D12.3 F58D12.3 Protein of unknown function, has weak similarity to C. elegans Y48G1A_53.E F58D2.1 F58D2.1 Protein containing a leucine rich repeat, which mediate protein-protein interactions, has weak similarity to a region of C. elegans ZYG-11, which is required for zygote formation C.elegans ZYG-11 protein like F58D2.2 F58D2.2 Protein of unknown function, has moderate similarity to uncharacterized C. elegans T08B6.4 F58D5.1 F58D5.1 Putative ortholog of H. sapiens NSAP1 (NS1-associated protein 1) F58D5.2 F58D5.2 Protein of unknown function F58D5.3 F58D5.3 Protein of unknown function, has strong similarity to C. elegans F08A8.5 F58D5.4 ksr-2;F58D5.4 Protein may be a serine/threonine kinase, and has similarity to H. sapiens and D. melanogaster KSR (kinase suppressor of ras) protein kinases F58D5.5 F58D5.5 Protein of unknown function, has weak similarity to C. elegans Y39B6B.GG F58D5.6 F58D5.6 Protein of unknown function, has weak similarity to C. elegans K02F6.4 F58D5.7 F58D5.7 Protein of unknown function, putative paralog of C. elegans C54G4.3 F58D5.8 F58D5.8 Protein of unknown function, has moderate similarity to C. elegans C09B9.2 F58D7.1 F58D7.1 Member of the rhodopsin family of G protein-coupled receptors (GPCR), has high similarity to uncharacterized C. elegans C04E6.2 7TM chemoreceptor, srsx family F58E1.1 F58E1.1 Member of the reverse transcriptase protein family, which are RNA-dependent DNA polymerases, has high similarity to uncharacterized C. elegans F40F12.2 reverse transcriptase F58E1.10 F58E1.10 Protein of unknown function, has high similarity to uncharacterized C. elegans F58E1.11 F58E1.11 F58E1.11 Protein of unknown function, has high similarity to uncharacterized C. elegans F58E1.10 F58E1.12 F58E1.12 Protein of unknown function, has high similarity to uncharacterized C. elegans K09F6.8 F58E1.13 F58E1.13 Protein with strong similarity to C. elegans C08E3.8 gene product F58E1.14 F58E1.14 Protein containing an F-box domain, which serve as a link between a target protein and a ubiquitin-conjugating enzyme, has moderate similarity to uncharacterized C. elegans K05F6.7 This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins. F58E1.2 F58E1.2 Protein containing an F-box domain, which serve as a link between a target protein and a ubiquitin-conjugating enzyme, has high similarity to uncharacterized C. elegans F58E1.3 This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins. F58E1.3 F58E1.3 Protein containing an F-box domain, which serve as a link between a target protein and a ubiquitin-conjugating enzyme, has high similarity to uncharacterized C. elegans F58E1.2 This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins. F58E1.4 F58E1.4 Member of an uncharacterized protein family F58E1.5 F58E1.5 Protein containing an F-box domain, which serve as a link between a target protein and a ubiquitin-conjugating enzyme, has low similarity to uncharacterized C. elegans F58E1.9 This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins. F58E1.6 F58E1.6 Member of the sodium or hydrogen exchanger family, which maintain the pH of actively metabolizing cells, has moderate similarity to a region of sodium-hydrogen exchanger 2 (human SLC9A2), which may play a role in sodium absorption Na+/H+ exchanger; nhx-6 encodes a sodium/proton exchanger expressed mainly in the basolateral plasma membranes of the most posterior and anterior cells of the intestine, but mainly in the apical surface of medial intestinal cells; nhx-6 has no obvious phenotype in mass RNAi screens; NHX-6 is thought to prevent intracellular acidification by catalysing the electroneutral exchange of extracellular sodium for an intracellular proton. F58E1.7 F58E1.7 Protein of unknown function, has strong similarity to C. elegans K07G6.A F58E1.8 F58E1.8 Protein containing an F-box domain, which serve as a link between a target protein and a ubiquitin-conjugating enzyme, has high similarity to uncharacterized C. elegans F58E1.9 This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins; this gene's encoded protein also contains leucine-rich repeats. F58E1.9 F58E1.9 Protein containing an F-box domain, which serve as a link between a target protein and a ubiquitin-conjugating enzyme, has high similarity to uncharacterized C. elegans F58E1.8 This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins. F58E10.1 F58E10.1 Protein of unknown function F58E10.2 end-1;F58E10.2 GATA transcription factor expressed in zygotes and required for development of the gut GATA family of transcription factors; end-1 encodes a GATA-like transcription factor sufficient to initiate endoderm differentiation and binds to the canonical target DNA sequence WGATAR with specificity similar to GATA-1 and D4 transcription factors; its expression bypasses requirement for maternal SKN-1 and the maternal Wnt signaling pathway in endoderm formation and it activates endoderm differentiation in isolated Xenopus ectoderm. F58E10.3 F58E10.3 Protein with high similarity to human DDX5, which is an ATP-dependent RNA helicase that has ATP-independent RNA renaturation activity and catalyses branch migration, contains a helicase conserved C-terminal domain ATP-dependent helicase (DEAD box) F58E10.4 aip-1;F58E10.4 Protein containing two AN1-like zinc finger domains, has a region of moderate similarity to mouse AA407930, which is an arsenite inducible RNA associated protein that binds RNA and may function in protecting cells from arsenite toxicity aip-1 encodes an AN-1-like zinc finger-containing protein homologous to arsenite-inducible RNA-associated protein (AIRAP), conserved among C. elegans, Drosophila, and mammals; like AIRAP itself, AIP-1 protects cells from arsenite toxicity; AIP-1 is a predicted RNA binding protein that may function in ubiquitin-mediated proteolysis following aresenite treatment; AIP-1 does not appear to be essential for viability, but is expressed at high levels in hypodermal and intestinal cells following such treatment. F58E10.5 end-3;F58E10.5 Protein involved in differentiation of intestinal cells; has moderate similarity to D. melanogaster pnr gene product GATA family of transcription factors; end-3 encodes a GATA zinc finger protein, paralogous to end-1, that helps specify mesoendodermal (as opposed to mesectodermal) lineages derived from the E blastomere. F58E10.6 F58E10.6 Member of the 7-transmembrane chemoreceptor family of G protein-coupled receptors (GPCR), has moderate similarity to uncharacterized C. elegans ZK228.5 F58E10.7 F58E10.7 Protein of unknown function, has high similarity to uncharacterized C. elegans F23D12.3 F58E2.2 F58E2.2 Protein of unknown function, has high similarity to uncharacterized C. elegans K03D3.2 F58E2.3 F58E2.3 Protein containing two DUF38 domains of unknown function and an F-box domain, which serve as a link between a target protein and a ubiquitin-conjugating enzyme, has high similarity to uncharacterized C. elegans F58E2.4 This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins; this gene's encoded protein also contains an FTH/DUF38 motif, which may also mediate protein-protein interaction. F58E2.4 F58E2.4 Protein containing two DUF38 domains of unknown function and an F-box domain, which serve as a link between a target protein and a ubiquitin-conjugating enzyme, has high similarity to uncharacterized C. elegans F58E2.3 F58E2.5 F58E2.5 Protein of unknown function, has low similarity to uncharacterized C. elegans ZK384.2 F58E2.7 F58E2.7 Protein of unknown function, has weak similarity to C. elegans K03D3.3 F58E2.9 F58E2.9 Member of an uncharacterized protein family 7TM chemoreceptor, srz family F58E6.1 stat-b;F58E6.1 Protein of unknown function, has a region of weak similarity to a region of signal transducer and activator of transcription 5B (human STAT5B), which mediates JAK kinase signal transduction and is a component of interleukin 2 receptor signalling SH2 domain; The F58E6.1 encodes a protein that may be involved in apoptosis. F58E6.10 unc-42;F58E6.10 Homeodomain transcription factor; similar over the homeodomain to many human and D. melanogaster homeodomain transcription factors; involved in recognition of pioneering axons by subsequent axons within the left bundle of the ventral nerve cord Homeobox domain; unc-42 encodes a paired-like homeodomain protein of the Q50 class; UNC-42 is required to specify the fate of ASH sensory neurons, AVA, AVD, and AVE interneurons, and a subset of motor neurons; unc-42 mutants fail to express cell-surface receptors required for differentiated neuronal function (sra-6, srb-6, glr-1, glr-5, and glr-6); UNC-42 is also required for AVKR and HSNL growth cones to follow the PVPR and PVQL pioneer axons, for axonal outgrowth in the backward command interneurons AVA, AVD, and AVE, and for inhibition of ectopic FMRFamide-positive and GABAergic axons; unc-42 mutants are defective in mechanosensation, backward motion, and regulation of egg-laying. F58E6.3 F58E6.3 Protein containing two epidermal growth factor (EGF)-like domains, has low similarity to a region of notch (Drosophila) homolog 2 (mouse Notch2), which is involved in cell fate determination during embryogenesis and morphogenesis EGF-like domain F58E6.4 F58E6.4 Protein of unknown function, has weak similarity to C. elegans F10G2.2 F58E6.5 F58E6.5 Protein containing a major sperm protein (MSP) domain, which are involved in sperm motility F58E6.6 F58E6.6 Protein of unknown function, has low similarity to uncharacterized C. elegans F58E6.8 F58E6.7 F58E6.7 Protein of unknown function F58E6.8 F58E6.8 Protein of unknown function, has low similarity to uncharacterized C. elegans F58E6.6 F58F12.1 F58F12.1 Protein containing an ATP synthase delta or epsilon chain long alpha-helix and beta-sandwich domains, has moderate similarity to delta subunit of F1-ATP synthase (S. cerevisiae Atp16p) ATP synthase F58F12.2 F58F12.2 Protein of unknown function F58F12.3 F58F12.3 Protein of unknown function, has low similarity to uncharacterized C. elegans K03H9.3 F58F6.1 F58F6.1 Protein containing two collagen triple helix repeats and one nematode cuticle collagen N-terminal domain, has high similarity to a region of C. elegans BLI-1, which is a putative collagen that plays a role in embryogenesis and morphogenesis and chemotaxis cuticular collagen F58F6.2 F58F6.2 Protein with high similarity to C. elegans SQT-3, which is a collagen that is involved in morphogenesis of an epithelium and cuticle synthesis, contains two collagen triple helix repeats and one nematode cuticle collagen N-terminal domain cuticular collagen F58F6.3 F58F6.3 Protein of unknown function F58F6.4 F58F6.4 Protein with high similarity to replication factor C 2 (human RFC2), which is a subunit of replication factor C (activator 1) that activates DNA polymerases and functions as an ATPase that loads proliferating cell nuclear antigen to the DNA template DNA replication factor; rfc-2 encodes a member of the AAA family that are ATPases associated with DNA replication and has highest similarity to the mouse Replication factor C 40 kDa subunit, and affects embryonic viability, fertility, and locomotion in a large-scale RNAi screen. F58F6.5 F58F6.5 Putative ortholog of C. elegans ZC196.8 gene product F58F6.6 F58F6.6 Protein of unknown function, has very strong similarity to uncharacterized C. elegans ZC196.9 F58F6.7 F58F6.7 Protein of unknown function F58F9.1 F58F9.1 Protein of unknown function, has high similarity to uncharacterized C. elegans F54H12.2 F58F9.2 F58F9.2 Protein with strong similarity to C. elegans C49A9.1 gene product F58F9.3 F58F9.3 Protein of unknown function, has moderate similarity to uncharacterized C. elegans M04C3.3 F58F9.4 F58F9.4 Protein of unknown function, has low similarity to uncharacterized C. elegans C49A9.1 F58F9.6 F58F9.6 Member of an uncharacterized protein family F58F9.7 F58F9.7 Member of the acyl-CoA oxidase protein family acyl-coenzyme A oxidase F58G1.1 F58G1.1 Protein containing a piwi domain and a PAZ (Piwi, Argonaut and Zwille) domain, which may mediate protein-protein interactions, has weak similarity to Golgi endoplasmic reticulum protein 95 (rat Gerp95), which interacts with Hsp90 F58G1.2 F58G1.2 Protein containing six C2H2 type zinc finger domains, which bind nucleic acids, has a region of low similarity to a region of CCCTC-binding factor (rat Ctcf), which is a transcription factor with multiple DNA binding specificities Zinc finger, C2H2 type (6 domains) F58G1.3 F58G1.3 Protein with high similarity to serine-threonine protein phosphatase PP1-2 minor type (S. pombe Sds21p), member of the serine or threonine protein phosphatase family Protein phosphatase-1 (PP1) (2 domains) F58G1.4 F58G1.4 Protein of unknown function, has weak similarity to uncharacterized C. elegans T05A7.1 F58G1.5 F58G1.5 Member of the class 2 lipase family, has moderate similarity to uncharacterized C. elegans C09E8.2 F58G1.6 F58G1.6 Protein of unknown function, has weak similarity to C. elegans Y17G7B.14 F58G1.7 F58G1.7 Protein of unknown function F58G1.8 F58G1.8 Protein with strong similarity to C. elegans F29C12.4 gene product F58G1.9 F58G1.9 Protein of unknown function F58G11.1 F58G11.1 Putative ortholog of S. cerevisiae Yol027p, a protein of unknown function Yeast cosmid 9642 hypothetical protein like F58G11.2 F58G11.2 Member of the DEAD or DEAH box ATP-dependent RNA helicase family and contains a helicase conserved C-terminal domain, has a region of low similarity to S. cerevisiae Ded1p, which is an ATP-dependent RNA helicase involved in protein synthesis ATP-dependent RNA helicase like F58G11.3 F58G11.3 Putative ortholog of C. elegans C38D4.4 gene product F58G11.4 F58G11.4 Protein of unknown function, has moderate similarity to uncharacterized C. elegans F57A8.7 F58G11.5 F58G11.5 Protein containing a G-patch domain, which are found in RNA processing proteins, has weak similarity to calcium homeostasis endoplasmic reticulum protein (human CHERP), which is involved in the regulation of IP3-induced calcium release from the ER F58G11.6 F58G11.6 Protein of unknown function, has low similarity to uncharacterized human LOC51622 F58G4.1 F58G4.1 Protein with high similarity to sarcomeric myosin heavy chain (C. elegans UNC-54), contains two IQ calmodulin-binding domains, a myosin head domain (motor domain), a coiled-coil myosin heavy chain tail region, and a myosin N-terminal SH3-like domain myosin F58G4.2 F58G4.2 Member of the 7-transmembrane chemoreceptor family of G protein-coupled receptors (GPCR), has low similarity to C. elegans ODR-10, which is a G protein-coupled receptor involved in odorant response 7TM chemoreceptor, str family F58G4.3 F58G4.3 Protein containing a DUF148 domain of unknown function, has moderate similarity to uncharacterized C. elegans F11F1.4 F58G4.4 F58G4.4 Protein containing an epidermal growth factor (EGF)-like domain F58G4.5 F58G4.5 Member of the 7-transmembrane chemoreceptor family of G protein-coupled receptors (GPCR), has low similarity to C. elegans ODR-10, which is a G protein-coupled receptor involved in odorant response 7TM chemoreceptor, str family F58G4.6 F58G4.6 Member of the 7-transmembrane chemoreceptor family of G protein-coupled receptors (GPCR), has low similarity to C. elegans ODR-10, which is a G protein-coupled receptor involved in odorant response 7TM chemoreceptor, str family F58G6.1 F58G6.1 Protein containing a Src homology 3 (SH3) domain and a BAR domain, which are found in amphiphysins and clathrin binding proteins, has low similarity to amphiphysin II (human BIN1), which regulates cellular apoptosis, proliferation and differentiation amphiphysin like F58G6.2 F58G6.2 Protein with strong similarity to C. elegans K12C11.3 gene product F58G6.3 F58G6.3 Protein with strong similarity to C. elegans K12C11.3 gene product F58G6.4 F58G6.4 Protein containing neurotransmitter-gated ion-channel ligand bindingand transmembrane domains, has moderate similarity to C. elegans MOD-1, which is a serotonin-gated chloride channel glycine receptor F58G6.5 nhr-34;F58G6.5 Member of the nuclear hormone receptor, C4-type zinc finger protein family nuclear hormone receptor; nhr-34 encodes a member of the nuclear receptor superfamily; phylogenetic analyses indicate that NHR-34 is a divergent nuclear receptor that likely arose from the expansion and diversification of the HNF4 (NR2A) subgroup in C. elegans; the role of NHR-34 in C. elegans development and/or behavior, and the NHR-34 expression pattern, are not yet known. F58G6.6 F58G6.6 Putative ortholog of C. elegans W09C2.4 gene product del-2 encodes an unfamiliar protein whose promoter drives expression in IL1, ASH, and OLQ. F58G6.7 F58G6.7 Protein with strong similarity to C. elegans K12C11.3 gene product F58H1.1 F58H1.1 Member of the glycosyl hydrolase family 38 of alpha-mannosidases, has moderate similarity to alpha-mannosidase II (human MAN2A1), which catalyzes the processing of N-linked glycans and may be associated with congenital dyserythropoietic anemia type II alpha-mannosidase F58H1.2 F58H1.2 Protein of unknown function F58H1.3 F58H1.3 Member of the haloacid dehalogenase or epoxide hydrolase family E-1 enzyme F58H1.4 F58H1.4 Protein of unknown function F58H1.5 F58H1.5 Protein of unknown function F58H1.6 F58H1.6 Putative ortholog of C. elegans M70.2 gene product F58H1.7 F58H1.7 Protein containing a low-density lipoprotein (LDL) receptor class A domain low-density lipoprotein receptor F58H10.1 F58H10.1 Protein of unknown function F58H12.1 kin-29;F58H12.1 Putative ortholog of C. elegans par-1 gene product serine/threonine-protein kinase; kin-29 encodes a serine/threonine kinase with significant homology in the kinase domain to the AMP-activated protein kinase (AMPK) and SNF1 kinases; the AMP-kinase cascade is activated by cellular stresses that deplete ATP; AMP-kinase is believed to protect the mammalian cell by 'switching off' ATP-consuming pathways like fatty acid synthesis, by phosphorylating key regulatory enzymes, and switching on alternative pathways for ATP generation; kin-29 is involved in regulating the expression of chemosensory receptors and entry into the daur pathway; kin-29 also affects body size via interaction with the Sma/Mab pathway and lifespan, with mutants exhibiting a smaller body size and increased life span; a functional KIN-29-GFP fusion protein is expressed in sensory neurons and many other cell types, and localizes to the cytoplasm; under conditions of cellular stress like heat shock and starvation, KIN-29-GFP translocates to the nucleus. F58H7.1 F58H7.1 Protein of unknown function F58H7.2 F58H7.2 Member of the amidase family, which catalyze hydrolysis of amides, has moderate similarity to fatty acid amide hydrolase (mouse Faah), which degrades neuromodulatory fatty acid amides and may be important for embryo development and implantation This gene encodes a protein predicted by Eisenberg and coworkers, with 52% accuracy, to be mitochondrial. F58H7.3 F58H7.3 Protein containing a neurotransmitter-gated ion-channel ligand binding domain, has a region of low similarity to a region of neuronal nicotinic acetylcholine receptor alpha 6 subunit (human CHRNA6), which may be involved in neural synaptic transmission F58H7.5 F58H7.5 Protein of unknown function F58H7.6 F58H7.6 Member of the reverse transcriptase protein family, which are RNA-dependent DNA polymerases, contains a retroviral integrase core domain, which are the central catalytic domains that can act as endonucleases F58H7.7 F58H7.7 Protein containing an F-box domain, which serve as a link between a target protein and a ubiquitin-conjugating enzyme This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins. F58H7.8 F58H7.8 Protein containing an F-box domain, which serve as a link between a target protein and a ubiquitin-conjugating enzyme, has low similarity to uncharacterized C. elegans F42G2.3 F59A1.10 F59A1.10 Protein of unknown function, has high similarity to uncharacterized C. elegans Y53G8B.2 F59A1.11 F59A1.11 Protein of unknown function, has moderate similarity to uncharacterized C. elegans F59A1.12 F59A1.12 F59A1.12 Protein of unknown function, has moderate similarity to uncharacterized C. elegans F59A1.11 F59A1.13 F59A1.13 Member of the sugar (and other) transporter family, has low similarity to solute carrier family 17 member 1 (mouse Slc17a1), which is involved in sodium-dependent phosphate transport and mediates hepatic and renal anion drug transport F59A1.3 F59A1.3 Member of the 7-transmembrane chemoreceptor family of G protein-coupled receptors (GPCR), has low similarity to C. elegans ODR-10, which is a G protein-coupled receptor involved in odorant response F59A1.4 F59A1.4 Member of the 7-transmembrane chemoreceptor family of G protein-coupled receptors (GPCR), has low similarity to C. elegans ODR-10, which is a G protein-coupled receptor involved in odorant response F59A1.6 F59A1.6 Protein of unknown function, has weak similarity to C. elegans W05B10.3 F59A1.7 F59A1.7 Protein containing an F-box domain, which serve as a link between a target protein and a ubiquitin-conjugating enzyme, and a DUF38 domain of unknown function, has a region of low similarity to C. elegans FOG-2, which is required for germ cell identity This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins; this gene's encoded protein also contains an FTH/DUF38 motif, which may also mediate protein-protein interaction. F59A1.8 F59A1.8 Protein of unknown function, has weak similarity to C. elegans T25E12.11 F59A1.9 F59A1.9 Protein containing an F-box domain, which serve as a link between a target protein and a ubiquitin-conjugating enzyme, has low similarity to uncharacterized C. elegans Y47H9C.11 F59A2.1 RANUP96;F59A2.1 Putative nucleoporin, has strong similarity to H. sapiens RANBP2L1 gene product [RAN binding protein 2-like 1 (GenBank)] Nucleoporin F59A2.2 F59A2.2 Protein with moderate similarity to C. elegans F59A2.6, has weak similarity to human MYH9, non-muscle myosin Coiled-coil protein F59A2.3 F59A2.3 Member of the MAM33 mitochondrial glycoprotein family, has low similarity to a region of complement component 1 q subcomponent binding protein (mouse C1qbp), which binds the globular heads of complement subcomponent C1q (mouse C1q) Splicing factor-associated 32K chain F59A2.4 F59A2.4 Protein with high similarity to ATP-GTP-binding protein (human HEAB), which is a subunit of the CFIIAm pre-mRNA cleavage complex that functions in pre-mRNA cleavage and is associated with acute monoblastic leukemia F59A2.5 F59A2.5 Protein of unknown function F59A2.6 F59A2.6 Protein containing a large coiled-coil domain and a putative golgi-localization (GRIP) domain F59A3.1 F59A3.1 Member of the carboxypeptidase A metalloprotease (M14) family of zinc carboxypeptidases, has low similarity to a region of carboxypeptidase D (mouse Cpd), which is a putative membrane-bound metalloprotease that may act in processing secretory proteins carboxypeptidase F59A3.10 F59A3.10 Protein of unknown function F59A3.2 F59A3.2 Protein of unknown function F59A3.3 F59A3.3 Member of the KOW (Kyprides-Ouzounis-Woese) motif family, which are either part of the large ribosomal subunit or transcriptional antitermination proteins F59A3.4 F59A3.4 Member of the ZIP zinc transporter family, which may be metal transporters F59A3.5 F59A3.5 Putative ortholog of C. elegans F59A3.6 gene product F59A3.6 F59A3.6 Protein of unknown function, has low similarity to uncharacterized C. elegans M04F3.1 F59A3.7 F59A3.7 Protein of unknown function F59A3.8 F59A3.8 Protein containing two Src homology 2 (SH2) domains and one protein kinase domain, has low similarity to human BMX, which is a non-receptor tyrosine kinase involved in STAT activation and regulation of breast cancer cell proliferation and tumorigenicity protein kinase F59A3.9 F59A3.9 Protein of unknown function, has a region of weak similarity to DNA polymerase kappa (S. pombe Cid1p), which is involved in caffeine sensitivity F59A6.1 nsy-1;F59A6.1 Protein containing a protein kinase domain, has moderate similarity to mitogen activated protein kinase kinase kinase 5 (apoptosis signal-regulating kinase 1, human MAP3K5), which activates SAPK, Jun kinase and p38 signaling pathways Protein kinase; nsy-1 encodes a MAP kinase kinase kinase homolog that affects chemotaxis, egg laying, and pathogen response; NSY-1 activity is activated by the calmodulin kinase UNC-43, and is required for lateral signalling that leads to asymmetric olfactory neuron fates; interacts with SEK-1, and is expressed in the intestine, hypodermis, rectal gland cells, and neurons. F59A6.2 F59A6.2 Protein of unknown function F59A6.3 F59A6.3 Protein of unknown function, has weak similarity to a region of S. pombe Nup124p, which is a nuclear pore complex protein required for spore germination Glycoprotein F59A6.4 F59A6.4 Protein containing two protein kinase domains, has a region of low similarity to putative casein kinase I (CKI, S. pombe Hhp1p), which is required for DNA repair Protein kinase F59A6.5 F59A6.5 Putative coiled-coil protein, has weak similarity to S. cerevisiae Uso1p, required for protein transport from ER to Golgi F59A6.6 F59A6.6 Member of the RNase H family, which digest the RNA strand of an RNA-DNA duplex, has low similarity to ribonuclease H1 (mouse Rnaseh1), which binds to double stranded RNA and DNA-RNA hybrids and degrades the RNA strand of DNA-RNA hybrids ribonuclease H; rnh-1 encodes a putative RNAse H that is predicted, by phylogenetic profiling, to be mitochondrial. F59A7.1 F59A7.1 Protein containing a C-type lectin domain, which mediate calcium-dependent carbohydrate recognition, has high similarity to uncharacterized C. elegans F38A1.5 F59A7.2 F59A7.2 Protein of unknown function, has high similarity to uncharacterized C. elegans R08E5.4 F59A7.3 F59A7.3 Protein of unknown function, has moderate similarity to uncharacterized C. elegans C33G8.5 7TM chemoreceptor, srab family F59A7.4 H1.6;F59A7.4 Protein with high similarity to histone H1 (C. elegans H1.4), member of the histone H1 and H5 family of linker histones histone H1 F59A7.5 F59A7.5 Protein of unknown function F59A7.6 F59A7.6 Protein of unknown function F59A7.7 F59A7.7 Putative ortholog of C. elegans F59A7.9 gene product This gene encodes a protein predicted by Eisenberg and coworkers, with 52% accuracy, to be mitochondrial. F59A7.8 F59A7.8 Protein containing a helicase conserved C-terminal domain and two SNF2 related N-terminal domains, has low similarity to a region of transcription termination factor RNA polymerase II (human TTF2), which is a DNA-dependent ATPase helicase F59A7.9 F59A7.9 Member of the pyridoxal phosphate dependent enzyme beta family, has moderate similarity to a region of cystathionine beta-synthase (beta-CTSase, S. cerevisiae Cys4p), which converts serine and homocysteine to cystathionine cysteine sythase F59B1.1 F59B1.1 Member of the 7-transmembrane chemoreceptor family of G protein-coupled receptors (GPCR), has low similarity to C. elegans ODR-10, which is a G protein-coupled receptor involved in odorant response 7TM chemoreceptor, str family F59B1.2 F59B1.2 Protein of unknown function F59B1.3 F59B1.3 Member of the rhodopsin family of G protein-coupled receptors (GPCR), has high similarity to uncharacterized C. elegans H12C20.5 7TM chemoreceptor, srx family F59B1.4 F59B1.4 Protein with moderate similarity to C. elegans F59B1.6 gene product F59B1.5 F59B1.5 Protein of unknown function, has high similarity to uncharacterized C. elegans F59B1.3 F59B1.6 F59B1.6 Protein with moderate similarity to C. elegans F59B1.4 gene product F59B1.7 F59B1.7 Protein of unknown function, has moderate similarity to uncharacterized C. elegans Y43B11AL.2 7TM chemoreceptor, srx family F59B1.8 F59B1.8 Protein containing a DUF 227 domain of unknown function F59B1.9 acr-23;F59B1.9 Protein containing a neurotransmitter-gated ion-channel ligand binding domain, has low similarity to C. elegans ACR-4, which is an acetylcholine-gated channel subunit channel protein; acr-23 encodes an alpha 7-like homomer-forming subunit of the nicotinic acetylcholine receptor (nAChR) superfamily which encode ligand-gated ion channels that regulate fast action of acetylcholine at neuromuscular junctions and in the nervous system; ACR-23 is a member of the DEG-3-like group of nAChR subunits which appears to be unique to nematodes. F59B10.1 F59B10.1 Protein of unknown function, has high similarity to uncharacterized C. elegans F21A10.2 pqn-47 encodes a protein with a glutamine/asparagine-rich domain, homologous to human C11orf9 and Drosophila CG3328, that is required for locomotion, vulval development, full body size, cuticular integrity, and general health in mass RNAi assays; pqn-47(cxP5915) homozygotes are sluggish. F59B10.2 F59B10.2 Protein with weak similarity to H. sapiens Hs.14894 (H.sapiens mRNA for TGN46 protein) F59B10.3 F59B10.3 Protein with strong similarity to C. elegans Y102A11A.7 gene product cadherin transmembranous domain F59B10.4 F59B10.4 Protein of unknown function F59B10.5 F59B10.5 Protein of unknown function F59B10.6 F59B10.6 Protein of unknown function F59B2.10 F59B2.10 Protein of unknown function F59B2.11 F59B2.11 Protein of unknown function F59B2.12 F59B2.12 Protein with weak similarity to dentin sialophosphoprotein (mouse Dspp), which may be proteolytically cleaved to form dentin phosphoprotein and dentin sialoprotein thereby contributing to dentin mineralization and tooth development F59B2.13 srq-1;F59B2.13 Putative 7 transmembrane receptor possible G protein coupled receptor F59B2.2 F59B2.2 Member of the transmembrane amino acid transporter (permease) family, has low similarity to lysosomal amino acid transporter 1 (rat Lyaat1), which transports gamma-aminobutyric acid, glycine, L-alanine, L-proline, and D-proline F59B2.3 F59B2.3 Member of the N-acetylglucosamine-6-phosphate deacetylase family, has moderate similarity to N-acetylglucosamine-6-P deacetylase (C. albicans NAG2), which acts in N-acetylglucosamine catabolism and plays a role in growth, adherence and virulence N-acetyl-glucosamine-6-phosphate deacetylase F59B2.5 F59B2.5 Protein containing a PCI (proteasome, COP9-complex and eIF3 ) or PINT (Proteasome, Int-6, Nip-1 and TRIP-15) domain, which are found in multi-protein complexes, has low similarity to S. cerevisiae Rpn6p, which is part of the 26S proteasome complex F59B2.6 F59B2.6 Protein of unknown function zif-1 encodes a SOCS-box protein that promotes establishment of the germ line by targetting germline proteins for cullin-dependent degradation in non-germline (somatic) cells; ZIF-1 binds germline CCCH-(zinc)-finger proteins and the E3 ubiquitin ligase subunit elongin C (ELC-1); while ZIF-1 has no obvious homologs, it may be analogous to the Drosophila SOCS-box protein GUSTAVUS, which is required for VASA localization to the germline and which does have mammalian homologs. F59B2.7 F59B2.7 Protein with high similarity to ras-related GTP-binding protein 6 human RAB6A, which is involved in intracellular protein trafficking, protein secretion, and retrograde (Golgi to ER) transport, member of the Ras superfamily of GTP binding proteins Rab6 (ras protein) F59B2.8 F59B2.8 Protein containing an F-box domain, which serve as a link between a target protein and a ubiquitin-conjugating enzyme, has moderate similarity to uncharacterized C. elegans F59B2.9 F-box domain.; This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins. F59B2.9 F59B2.9 Protein containing an F-box domain, which serve as a link between a target protein and a ubiquitin-conjugating enzyme, has moderate similarity to uncharacterized C. elegans F59B2.8 F-box domain.; This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins. F59B8.1 F59B8.1 Protein of unknown function F59B8.2 F59B8.2 Protein with high similarity to cytosolic NADP(+)-dependent isocitrate dehydrogenase (rat Idh1), which catalyzes the oxidative decarboxylation of isocitrate into alpha-ketoglutarate, member of the isocitrate and isopropylmalate dehydrogenase family isocitrate dehydrogenase F59C12.1 cdh-9;F59C12.1 Protein containing two cadherin domains, has low similarity to a region of cadherin EGF LAG seven-pass G-type receptor (mouse Celsr1), which is a seven-pass transmembrane domain putative receptor which may act in contact-mediated cell communication cadherin-type repeat; cdh-9 encodes a member of the cadherin superfamily of transmembrane glycoproteins that mediate homophilic cell-cell adhesion; as loss of CDH-9 activity via RNA-mediated interference (RNAi) does not result in any abnormalities, the precise role of CDH-9 in C. elegans development and/or behavior is not yet known. F59C12.2 5HT-Ce2;F59C12.2 Serotonin (5-hydroxytryptamine) receptor, member of the G protein-coupled receptor family G-protein coupled receptor, family 1 F59C12.3 F59C12.3 Putative coiled-coil protein, has similarity to human a centromere protein CENPE F59C6.1 F59C6.1 TcA transposase Tc1 transposase F59C6.11 F59C6.11 Protein with strong similarity to C. elegans F59C6.3 gene product F59C6.11 encodes a claudin homolog that may be required for normal cohesion of apical junctions in epithelia; F59C6.11 is worm-specific, with obvious homologs only in C. elegans; F59C6.11 has no obvious function in mass RNAi assays; claudins are integral membrane proteins with four transmembrane sequences that are found in mammalian tight junctions (TJs), induce TJs when transgenically expressed in cells normally lacking them, and can mediate the specific conductance of of specific ions (e.g., magnesium or calcium) through TJs while blocking the flow of water. F59C6.2 F59C6.2 Protein containing a DHHC-type zinc finger (NEW1) domain, has low similarity to uncharacterized C. elegans C43H6.7 F59C6.3 F59C6.3 Protein with strong similarity to C. elegans F59C6.11 gene product F59C6.4 F59C6.4 Protein with low similarity to S. cerevisiae Rrp40p, which is a component of the exosome complex involved in 3' end processing and degradation of many RNA species F59C6.5 F59C6.5 Protein of unknown function, has moderate similarity to H. sapiens NDUFB10 gene product, NADH:ubiquinone oxidoreductase PDSW subunit NADH ubiquinone oxidoreductase F59C6.6 F59C6.6 neuropeptide neurotrasmitter nlp-4 encodes three predicted neuropeptide-like proteins; nlp-4 has no none homologs in other nematode species, and its expression pattern has not been determined; in addition, as loss of nlp-4 activity via large-scale RNAi screens does not result in any obvious abnormalities, the precise role of nlp-4-encoded peptides in development and/or behavior is not yet known. F59C6.7 F59C6.7 Protein of unknown function che-13 encodes a novel protein homologous to mammalian IFT57/Hippi (OMIM:606621, protein interactor of Huntingtin-interacting protein 1 that is implicated in neuronal apoptosis in the Huntington disease state); CHE-13 is a proposed component of the intraflagellar transport (IFT) complex B, and is required for the construction and maintenance of cilia on a subset of sensory neurons; in addition, CHE-13 is required for proper localization of OSM-5, a murine polaris homolog, to IFT complex B; CHE-13 is expressed in ciliated sensory neurons including the amphids, phasmids, inner and outer labial neurons, and sensory rays of the male tail, localizing to the cilia base (transition zone) as well as to the axoneme; che-13 expression, like that of ciliogenic genes osm-1, osm-5, osm-6, and che-2, is positively regulated by the DAF-19 RFX-type transcription factor. F59C6.8 F59C6.8 Protein containing two DUF23 domains of unknown function F59C6.9 F59C6.9 Protein of unknown function F59D12.1 F59D12.1 Member of the rhodopsin family of G protein-coupled receptors (GPCR), has low similarity to neuropeptide Y-Y2 receptor (human NPY2R), which signals through intracellular cAMP levels and calcium flux G-protein coupled receptor (gastrin/cholecystokinin) F59D12.2 F59D12.2 Protein of unknown function F59D12.3 F59D12.3 Protein of unknown function, has low similarity to uncharacterized C. elegans C41C4.1 F59D12.4 F59D12.4 Member of the glypican family of heparan sulfate proteoglycans, has weak similarity to glypican 4 (k-glypican) (mouse Gpc4), which is a cell surface heparan sulfate proteoglycan that binds mouse Fgf2 glypican; gpn-1 encodes a glypican, a heparan sulfate proteoglycan anchored to the cell membrane by a GPI linkage, that is orthologous to Drosophila Dally-like (Dlp) and mammalian glypicans (OMIM:312870, mutated in Simpson-Golabi-Behmel overgrowth syndrome); by homology, GPN-1 is predicted to function as a cell surface protein that regulates intercellular signaling, perhaps within the context of cell division and growth regulation; however, as loss of gpn-1 activity via large-scale RNAi screens does not result in any obvious abnormalities, the precise role of GPN-1 in C. elegans development and/or behavior is not yet known. F59D12.5 F59D12.5 Protein of unknown function F59D6.1 F59D6.1 Protein of unknown function, has weak similarity to C. elegans EGAP4.1 F59D6.2 F59D6.2 Member of the protease protein family aspartyl protease F59D6.3 F59D6.3 Putative aspartyl protease, has similarity to human and S. cerevisiae aspartyl proteases, putative paralog of C. elegans F59D6.2 aspartyl protease F59D6.4 F59D6.4 Protein containing a DUF41 domain of unknown function, has high similarity to uncharacterized C. elegans ZC482.4 F59D6.5 F59D6.5 Protein of unknown function, has moderate similarity to uncharacterized C. elegans H10D18.3 7TM chemoreceptor, srw family F59D6.6 F59D6.6 Protein containing a DUF41 domain of unknown function, has moderate similarity to uncharacterized C. elegans ZC482.2 F59D6.7 F59D6.7 Member of an uncharacterized protein family F59D8.A vit-3;F59D8.1;F59D8.A Member of the vitellogenin protein family F59D8.B vit-4;yp170A;F59D8.2;F59D8.B Member of the vitellogenin protein family; expressed only in C. elegans intestinal cells F59D8.E F59D8.E Putative ortholog of C. elegans F56B6.1 gene product F59D8.F F59D8.F Protein of unknown function, putative paralog of C. elegans F59D8.D F59E10.1 orc-2;ceOrc2;F59E10.1 Protein with low similarity to origin recognition complex subunit 2 (yeast homolog)-like (human ORC2L), which is likely required for initiation of DNA replication and may have a role in transcriptional silencing origin recognition complex, second largest subunit ORC2 F59E10.2 cyp-4;mog-6;F59E10.2 Cyclophilin-related peptidylprolyl cis-trans-isomerase cyclophilin; cyp-4 encodes a peptidyl-propyl cis-trans isomerase of the cyclophilin family that is required for sexual differentiation of germ cells in hermaphrodites and affects body-wall muscle cell development; expression is most abundant in early larval stages and is observed exclusively in body- wall striated muscle cells. F59E10.3 F59E10.3 Member of the clathrin adaptor complex small chain family, has low similarity to coatomer (COPI) complex zeta chain (zeta-COP) (S. cerevisiae Ret3p), which is required for retrograde Golgi to endoplasmic reticulum transport Clathrin adaptor complex small chain; F59E10.3 encodes a zeta subunit of the coatomer (COPI) complex; in mass RNAi assays, F59E10.3 is required for embryonic, larval, and adult viability, for fertility, and for normal osmoregulation. F59E11.1 F59E11.1 Protein of unknown function, has moderate similarity to uncharacterized C. elegans R03H4.2 7TM chemoreceptor, srx family F59E11.10 F59E11.10 Member of the nuclear hormone receptor/Zinc finger protein family zinc finger protein F59E11.11 F59E11.11 Member of the nuclear hormone receptor/Zinc finger protein family F59E11.12 F59E11.12 Member of the nuclear hormone receptor/Zinc finger protein family F59E11.13 F59E11.13 Member of the 7-transmembrane chemoreceptor family of G protein-coupled receptors (GPCR), has low similarity to C. elegans ODR-10, which is involved in odorant response 7TM chemoreceptor, str family F59E11.14 F59E11.14 Member of the 7-transmembrane chemoreceptor family of G protein-coupled receptors (GPCR), has low similarity to C. elegans ODR-10, which is involved in odorant response 7TM chemoreceptor, str family F59E11.15 F59E11.15 Member of the 7-transmembrane chemoreceptor family of G protein-coupled receptors (GPCR), has low similarity to C. elegans ODR-10, which is involved in odorant response 7TM chemoreceptor, str family F59E11.16 F59E11.16 Member of the 7-transmembrane chemoreceptor family of G protein-coupled receptors (GPCR), has low similarity to C. elegans ODR-10, which is involved in odorant response 7TM chemoreceptor, str family F59E11.2 F59E11.2 Member of the alcohol dehydrogenase protein family This gene encodes a protein predicted by Eisenberg and coworkers, with 68% accuracy, to be mitochondrial. F59E11.4 F59E11.4 Protein of unknown function, has high similarity to uncharacterized C. elegans K03F8.1 F59E11.5 F59E11.5 Protein of unknown function, has low similarity to uncharacterized C. elegans F59E11.7 F59E11.6 F59E11.6 Protein containing a DUF19 domain of unknown function, which contain twelve conserved cysteines, has low similarity to uncharacterized C. elegans F59E11.7 F59E11.7 F59E11.7 Protein of unknown function, has low similarity to uncharacterized C. elegans F59E11.5 F59E11.8 F59E11.8 Member of the nuclear hormone receptor/Zinc finger protein family zinc finger protein F59E12.1 F59E12.1 Protein with weak similarity to H. sapiens Hs.159613 (Human mRNA for KIAA0181 gene, partial cds) F59E12.10 F59E12.10 Protein of unknown function F59E12.11 F59E12.11 Protein of unknown function F59E12.12 bli-2;F59E12.12 Protein containing two collagen triple helix repeats and a nematode cuticle collagen N-terminal domain, has a region of high similarity to a region of C. elegans BLI-1, which is a likely collagen involved in embryogenesis and morphogenesis and chemotaxis A cuticle collagen involved in strut assembly in the adult cuticle. F59E12.13 F59E12.13 Member of the glycosyltransferase family 10 of fucosyltransferases, has low similarity to fucosyltransferase 5 (alpha (1,3) fucosyltransferase, human FUT5), which transfers fucose to oligosaccharide acceptors and synthesizes Lewis x cell surface epitopes F59E12.2 zyg-1;F59E12.2 Required, possibly maternally for centrosome separation and possibly duplication zyg-1 encodes a homolog of polo-like and calcium-dependent kinases that is required for the cell cycle; specifically, it is required for daughter centriole formation. F59E12.3 F59E12.3 Protein containing two protein kinase domains, has low similarity to C. elegans KIN-19, which is a putative casein kinase 1 that appears to regulate polarity of the EMS blastomere F59E12.4 F59E12.4 Member of the nuclear pore Npl4p-like protein family F59E12.5 F59E12.5 Protein with moderate similarity to S. cerevisiae Npl4p, which is a nuclear pore protein F59E12.6 F59E12.6 Member of the ubiquitin carboxyl-terminal hydrolase family 2, which are cysteine proteases involved in deubiquination, contains a ubiquitin carboxyl-terminal hydrolases family 2 domain F59E12.7 F59E12.7 Protein with strong similarity to C. elegans C17G10.9 gene product F59E12.8 F59E12.8 Protein containing a ligand-gated ion channel domain, which are found in ionotropic glutamate receptors and NMDA receptors F59E12.9 F59E12.9 Coiled-coil protein, has weak similarity to myosins and S. cerevisiae Uso1p F59F3.1 F59F3.1 Protein containing two protein kinase domains and four immunoglobulin domains, has weak similarity to fms related tyrosine kinase 1 (vascular endothelial growth factor-vascular permeability factor receptor, mouse Flt1), which functions in angiogenesis IG (immunoglobulin) superfamily (3 domains), tyrosine-protein kinase (KIN15/KIN16 subfamily) (2 domains) F59F3.2 F59F3.2 Protein containing two collagen triple helix repeats, has a region of moderate similarity to a region of C. elegans BLI-1, which is a putative collagen that is involved in embryogenesis and morphogenesis and chemotaxis collagen F59F3.4 F59F3.4 Member of the amiloride-sensitive sodium channel family, which are involved in sodium reabsorption F59F3.5 F59F3.5 Protein containing four immunoglobulin (Ig) domains and a protein kinase domain, has weak similarity to fms related tyrosine kinase 1 (vascular endothelial growth factor-vascular permeability factor receptor, human FLT1), which functions in angiogenesis IG (immunoglobulin) superfamily (3 domains), tyrosine-protein kinase (KIN15/KIN16 subfamily) F59F4.1 F59F4.1 Member of the acyl-CoA oxidase family, which convert acyl-CoA into trans-2-enoyl-CoA, has moderate similarity to peroxisomal acyl-coenzyme A oxidase (rat RATACOA1), which catalyzes the first step in very long chain fatty acid beta-oxidation acyl-CoA oxidase I F59F4.2 F59F4.2 Protein with high similarity to ribosome associated membrane protein 4 (Stress-associated endoplasmic reticulum protein 1, human SERP1), which may be involved in membrane biogenesis, protein glycosylation, and the response to stress F59F4.3 F59F4.3 Protein of unknown function F59F4.4 F59F4.4 Member of the phospholipid and glycerol acyltransferase family, has moderate similarity to lysophosphatidic acid acyltransferase-alpha (1-acyl sn-glycerol-3-phosphate acyltransferase, human AGPAT1), which acts in phosphatidic acid biosynthesis 1-acyl-SN-glycerol-3-phosphate acyltransferase F59F5.1 F59F5.1 Protein with weak similarity to H. sapiens SLC16A3 (solute carrier family 16 (monocarboxylic acid transporters), member 3) F59F5.2 F59F5.2 Putative ortholog of C. elegans XL153 gene product F59F5.3 F59F5.3 Protein containing a protein kinase domain, has a region of low similarity to a region of v-abl Abelson murine leukemia viral oncogene homolog 2 (ARG) (human ABL2), which is a cytoplasmic protein tyrosine kinase tyrosine-protein kinase F59F5.4 F59F5.4 Protein with weak similarity to C. elegans col-1 (Collagen) collagen F59F5.5 F59F5.5 Protein of unknown function F59F5.6 syd-2;liprin-alpha;F59F5.6 Member of liprin (LAR-interacting protein) family of proteins liprin-alpha; syd-2 encodes alpha-liprin, a member of the liprin family of proteins that interact with LAR (leukocyte common antigen related)-type receptor tyrosine phosphatases (RPTPs) to facilitate clustering of RPTPs to focal adhesions; SYD-2 is required for establishing normal presynaptic density, and is expressed in all neurons and muscles; SYD-2 is required cell autonomously in neurons for differentiation of presynaptic active zones, where SYD-2 is localized. F59F5.7 F59F5.7 Protein of unknown function F59F5.8 F59F5.8 Protein of unknown function F59G1.1 F59G1.1 Member of the glycosyl transferase family 2, has moderate similarity to UDP-glucose ceramide glucosyltransferase (human UGCG), which catalyzes the biosynthesis of glucosylceramide and may act in cell-HIV-1 fusion and multidrug resistance to chemotherapy F59G1.2 F59G1.2 Member of the tetraspanin family, which contain an N-terminal transmembrane domain that is a signal sequence and membrane anchor transpanin F59G1.3 F59G1.3 Protein with low similarity to S. cerevisiae Vps35p, which is involved in vacuolar sorting S. cerevisiae vacuolar sorting protein F59G1.4 F59G1.4 Protein of unknown function F59G1.5 stp-1;ptp-2;F59G1.5 Putative protein tyrosine phosphatase PROTEIN-TYROSINE PHOSPHATASE F59G1.7 F59G1.7 Protein with strong similarity to human FRDA (Friedreich ataxia 1), frataxin, may be involved in iron homeostasis and free radical toxicity in the mitochondria frh-1 encodes an ortholog of human frataxin (FRDA; OMIM:136533), which when mutated leads to Friedreich ataxia (OMIM:229300). F59G1.8 F59G1.8 Protein of unknown function F59H5.1 F59H5.1 Putative ortholog of C. elegans F28H6.4 gene product F59H5.1 encodes an unfamiliar protein with a low-complexity N-terminal region and a C-terminal DUF545 motif (of unknown function, found solely in nematode proteins); F59H5.1 is expressed in neuronal head ganglia, intestinal cells, hypodermal cells, and coelomocytes, with strong expression in embryos; F59H5.1 has no obvious function or phenotype in RNAi assays, whether in a normal background or in goa-1(-) or goa-1(gf) mutant backgrounds. F59H5.3 F59H5.3 Protein containing a meprin and TRAF homology (MATH) domain, has high similarity to uncharacterized C. elegans F40B1.1 F59H6.1 F59H6.1 Putative ortholog of C. elegans F59H6.A gene product F59H6.3 F59H6.J;F59H6.3 Protein of unknown function, has weak similarity to C. elegans wee-1.3 F59H6.4 F59H6.4 Putative ortholog of C. elegans C16C4.14 gene product F59H6.7 F59H6.F;F59H6.7 Protein containing a cyclin N-terminal domain, has very strong similarity to uncharacterized C. elegans F08F1.9 F59H6.9 F59H6.9 Protein of unknown function, contains similarity to Pfam domain PF00651 F59H6.C F59H6.11;F59H6.C Protein containing a meprin and TRAF homology (MATH) domain and a BTB (BR-C, ttk and babor) or POZ (Pox virus and zinc finger) domain, which are found in some DNA and actin binding proteins, has high similarity to uncharacterized C. elegans F52C6.9 F59H6.D F59H6.10;F59H6.D Protein containing a BTB or POZ domain, which are found in some DNA and actin binding proteins and may mediate protein-protein interactions, and two meprin and TRAF homology domains, has strong similarity to uncharacterized C. elegans F52C6.8 F59H6.E F59H6.8;F59H6.E Protein containing a meprin and TRAF homology domain and a BTB (BR-C, ttk and babor) or POZ (Pox virus and zinc finger) domain, has high similarity to uncharacterized C. elegans F59H6.9 F59H6.H F59H6.6;F59H6.H Protein of unknown function F59H6.I F59H6.5;F59H6.I Putative paralog of C. elegans ZK250.9 gene product F59H6.K F59H6.2;F59H6.K Protein of unknown function, has strong similarity to C. elegans K09F6.6 F59H6.L F59H6.12;F59H6.L Protein containing a BTB (BR-C, ttk and babor) or POZ (Pox virus and zinc finger) domain, which are found in some DNA and actin binding proteins and may mediate protein-protein interactions, has high similarity to uncharacterized C. elegans F47C10.2 FLR-1 flr-1 Membrane protein that confers wild-type sensitivity to fluoride; member of the DEG/ENaC superfamily of proteins GAR-2 gar-2 Member of the G protein-linked acetylcholine receptor family H01A20.1 nhr-3;H01A20.1 Member of the nuclear hormone receptor/Zinc finger protein family Zinc finger, C4 type (two domains) H01G02.1 H01G02.1 Protein with moderate similarity to C. elegans F19B6.3 gene product H01G02.2 H01G02.2 Protein containing two protein kinase domains, has low similarity to cyclin-dependent protein kinase 2 (human CDK2), which interacts with cyclins to regulate kinase activity and cell cycle progression, and which regulates DNA replication serine/threonine kinase (2 domains) H01M10.1 H01M10.1 Protein of unknown function H01M10.2 H01M10.2 Protein of unknown function H02F09.1 H02F09.1 Protein of unknown function H02F09.2 H02F09.2 Protein of unknown function, has similarity to C. elegans K06A9.1A H02F09.3 H02F09.3 Protein with weak similarity to S. cerevisiae Egtp, which is a cell-cycle regulation protein that may be involved in the correct timing of cell separation after cytokinesis H02F09.4 H02F09.4 Member of the reverse transcriptase protein family, which are RNA-dependent DNA polymerases, has high similarity to uncharacterized C. elegans F38E9.3 reverse transcriptase H02I12.1 H02I12.1 Protein containing twelve chitin binding peritrophin-A domains, which contain six conserved cysteines that probably form three disulphide bridges, has a region of low similarity to C. elegans CEJ-1, which is involved in embryogenesis and morphogenesis H02I12.2 H02I12.2 Protein containing an F-box domain, which serve as a link between a target protein and a ubiquitin-conjugating enzyme This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins. H02I12.3 H02I12.3 Member of the rhodopsin family of G protein-coupled receptors (GPCR), has low similarity to uncharacterized C. elegans C01F1.4 7 transmembrane receptor (rhodopsin family) H02I12.4 H02I12.4 Protein containing a delta serrate ligand (DSL) domain, has a region of moderate similarity to a region of C. elegans LAG-2, which appears to interact with C. elegans LIN-12 and C. elegans GLP-1 Notch receptors to influence cell fate decisions EGF-like domain H02I12.5 H02I12.5 Protein of unknown function, has strong similarity to uncharacterized C. elegans Y17G9B.9 H02I12.6 H02I12.6 Member of the histone H2B protein family Core histones H2A, H2B, H3 and H4; his-66 encodes an H2B histone. H02I12.7 H02I12.7 Member of the histone H2A protein family Core histones H2A, H2B, H3 and H4; his-65 encodes an H2A histone. H02I12.8 H02I12.8 Member of the cytochrome P450 family, has moderate similarity to cytochrome P450 subfamily 4F polypeptide 2 (human CYP4F2), which is an arachidonic acid- and leukotriene B4 omega-hydroxylase that regulates salt and water homeostasis in liver and kidney Cytochrome P450 H02K04.1 H02K04.1 Member of the C-type lectin family Lectin C-type domain H03A11.1 H03A11.1 Protein of unknown function, has moderate similarity to uncharacterized human KIAA0475 H03A11.2 H03A11.2 Protein of unknown function H03E18.1 H03E18.1 Protein containing five PAN domains, which may mediate protein-protein or protein-carbohydrate interactions H03E18.2 H03E18.2 Protein of unknown function H03G16.1 H03G16.1 Protein containing a DUF38 domain of unknown function H03G16.2 H03G16.2 Protein of unknown function, has weak similarity to C. elegans F40F12.4 H03G16.3 H03G16.3 Protein of unknown function, has a region of weak similarity to a region of immunoglobulin mu binding protein 2 (rat Ighmbp2), which is a DNA binding protein that functions as a transcriptional regulator H03G16.4 H03G16.4 Protein containing an F-box domain, which serve as a link between a target protein and a ubiquitin-conjugating enzyme, and a DUF38 domain of unknown function, has high similarity to uncharacterized C. elegans C18B12.5 This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins; this gene's encoded protein also contains an FTH/DUF38 motif, which may also mediate protein-protein interaction. H03G16.5 H03G16.5 Protein with weak similarity to S. cerevisiae USO1 (Coiled-coil protein with similarity to mammalian integrin, required for protein transport from ER to Golgi) H04D03.1 H04D03.1 Putative ortholog of C. elegans W05F2.2 gene product H04D03.2 H04D03.2 Protein of unknown function, has a region of very strong similarity to a region of heterochromatin protein 1 family protein (C. elegans HPL-2), which is required for vulval development and germ line silencing H04D03.3 H04D03.3 Putative ortholog of C. elegans D2045.2 gene product H04J21.1 H04J21.1 Protein containing a WSN domain of unknown function, has moderate similarity to uncharacterized C. elegans R155.4 H04J21.2 H04J21.2 Protein of unknown function, has high similarity to uncharacterized C. elegans F48F5.4 7TM chemoreceptor, srd family H04J21.3 H04J21.3 Protein of unknown function gip-1 encodes the C. elegans homolog of Saccharomyces cerevisiae Spc98p, a gamma-tubulin-binding protein that with Spc97p forms part of a gamma-tubulin ring complex that can nucleate microtubule formation in vitro and in vivo; in C. elegans, GIP-1 is essential for embryogenesis and required for formation of centrosomal asters during interphase and formation of the mitotic spindle, but not for formation of mitotic asters; GIP-1 colocalizes with TBG-1/gamma-tubulin to centrosomes during interphase and mitosis; GIP-1 and TBG-1 are required reciprocally for centrosomal localization. H04M03.2 H04M03.F;H04M03.2 Protein of unknown function, has weak similarity to C. elegans F38A5.12 H04M03.3 H04M03.E;H04M03.3 Member of the short-chain dehydrogenase-reductase family, which are NAD- or NADP-dependent oxidoreductases H04M03.4 H04M03.D;H04M03.4 Protein of unknown function H04M03.5 H04M03.5 Protein with strong similarity to C. elegans C06E7.7 gene product H05B21.2 H05B21.2 Member of the 7-transmembrane chemoreceptor family of G protein-coupled receptors (GPCR), has high similarity to uncharacterized C. elegans C31B8.13 7TM chemoreceptor, srh family H05B21.3 H05B21.3 Protein of unknown function, has strong similarity to uncharacterized C. elegans H27D07.2 7TM chemoreceptor, srw family H05B21.4 H05B21.4 Protein of unknown function, has high similarity to uncharacterized C. elegans H27D07.3 7TM chemoreceptor, srw family H05C05.1 H05C05.1 Protein of unknown function H05C05.2 H05C05.2 Protein of unknown function, has weak similarity to C. elegans F23C8.J H05C05.3 H05C05.3 Protein of unknown function, has high similarity to uncharacterized C. elegans Y54G2A.20 H05G16.1 H05G16.1 Protein containing one FERM domain (Band 4.1 family), which link cytoplasmic proteins to membranes, has a region of low similarity to mouse Epb4.1l1, which is a GTPase inhibitor Band 4.1 family; frm-3 encodes a protein containing a FERM domain (Band 4.1 family); expressed in a few cells in the head. H05L03.3 H05L03.3 Protein of unknown function H05L14.1 H05L14.1 Protein containing three protein kinase domains, has a region of low similarity to casein kinase 1 alpha 1 (rat Csnk1a1), which is a serine/threonine protein kinase that may play a role in signal transduction casein kinase H05L14.2 H05L14.2 Protein with weak similarity to H. sapiens MYH9 (myosin, heavy polypeptide 9, non-muscle) Zinc finger, C3HC4 type (RING finger) H05O09.1 H05O09.1 Putative member of Immunoglobulin superfamily H06A10.1 H06A10.1;cdk-4 Protein with strong similarity to C. elegans XG314 gene product H06H21.1 H06H21.1 Protein of unknown function, has high similarity to uncharacterized C. elegans H06H21.2 7TM chemoreceptor, srw family H06H21.10 H06H21.10 Protein with moderate similarity to aminophospholipid ATPase transporter (Familial intrahepatic cholestasis 1, human ATP8B1), which is a putative P-type ATPase associated with familial intrahepatic cholestasis when deficient ATPase H06H21.2 H06H21.2 Protein of unknown function, has high similarity to uncharacterized C. elegans H06H21.1 7TM chemoreceptor, srw family H06H21.3 H06H21.3 Protein with high similarity to translation initiation factor eIF1A (S. cerevisiae Tif11p), member of the eukaryotic initiation factor 1A family of translation factors translation initiation factor H06H21.6 H06H21.6 Protein of unknown function H06H21.7 H06H21.7 Protein of unknown function H06H21.8 H06H21.8 Protein of unknown function, has strong similarity to C. elegans D1044.1 H06H21.9 H06H21.9 Protein with strong similarity to C. elegans C50F7.3 gene product H06I04.1 H06I04.1 Protein of unknown function, has moderate similarity to C. elegans Y53G8B_93.E H06I04.2 H06I04.2 Protein with strong similarity to H. sapiens SURF1 (surfeit 1) The sft-1 gene encodes a homolog of the human gene SURF1, which when mutated leads to Leigh syndrome (OMIM:256000). H06I04.3 H06I04.3 Putative ortholog of S. cerevisiae SPB1 gene product; Putative S-adenosyl-methionine-dependent methyltransferase required for synthesis of 60S ribosomal subunit H06I04.5 H06I04.5 Putative paralog of C. elegans F54F12.1 protein-tyrosine phoshatase H06I04.F H06I04.4;H06I04.F Fusion protein comprised of ribosomal protein S31 at the C-terminal half fused to ubiquitin at the N-terminal half H06O01.1 ceERp57;H06O01.1 Member of the protein disulfide isomerase protein family of transglutaminases protein disulphide isomerase ER-60 precursor like; pdi-3 encodes a protein disulfide isomerase (PDI) required for normal cuticle collagen deposition and, subliminally, for maintenance of normal body shape; PDI-3 has both PDI and calcium-dependent transglutaminase activity in vitro, crosslinking proteins through a gamma-glutamyl epsilon-lysine dual residue; PDI-3 is homologous to the human PDI ERp60, as well as a homolog in the dog heartworm Dirofilaria immitis that is required for larval molting; the joint PDI/transglutaminase activity of PDI-3 is biochemically conserved in nematodes and mammals; pdi-3 is constitutively and broadly expressed, particularly in gut and hypodermis. H06O01.2 H06O01.2 Protein containing two Chromo domains, which bind chromatin, an SNF2 related N-terminal domain, and a helicase conserved C-terminal domain, has moderate similarity to chromo domain helicase DNA binding protein 1 (mouse Chd1) chromodomain-helicase-DNA-biniding protein H06O01.3 H06O01.3 Protein containing a CRAL-TRIO domain, has low similarity to SEC14-like 2 (human SEC14L2), which is an alpha-tocopherol-binding protein that translocates from the cytosol to the nucleus and activates transcription retinal-binding protein like H06O01.4 H06O01.4 Member of the protein-tyrosine phosphatase family, which are involved in control of cell growth, proliferation, differentiation and transformation protein-tyrosine phosphatase H08J11.2 H08J11.2 Putative ortholog of C. elegans H08J11.A gene product H08J11.B H08J11.1;H08J11.B Protein of unknown function H08J19.1 H08J19.1 Protein of unknown function H08M01.1 H08M01.1 Protein with moderate similarity to C. elegans C34F11.1 gene product Zinc finger, C3HC4 type (RING finger) H08M01.2 H08M01.2 Protein containing a RhoGAP (GTPase activator protein) domain, has a region of low similarity to a region of beta 2-chimaerin (human CHN2), which is a GTPase activating protein for RAC1 and a high affinity receptor for diacylglycerol and phorbol esters GTPase-activator protein for Rho-like GTPases H09F14.1 H09F14.1 Member of the rhodopsin family of G protein-coupled receptors (GPCR), has weak similarity to somatostatin receptor 2 (human SSTR2), which inhibits adenylyl cyclase and mediates inhibition of cell proliferation and secretion of pituitary hormones 7 transmembrane receptor (rhodopsin family) H09G03.1 H09G03.1 Protein of unknown function H09G03.2 H09G03.2 Protein containing a WW domain, which bind proline-rich peptide epitopes, and a PDZ, DHR, or GLGF domain, which are found in signaling proteins frm-8 encodes a protein containing a WW domain, a PDZ domain, and a FERM domain and has homology to the human predicted protein KIAA0316. H09I01.1 H09I01.1 Protein of unknown function, has weak similarity to C. elegans F21H12.3 H10D12.2 H10D12.2 Protein of unknown function H10D18.1 H10D18.1 Protein of unknown function H10D18.2 H10D18.2 Putative paralog of C. elegans H10D18.4 H10D18.3 H10D18.3 Protein of unknown function, has strong similarity to C. elegans R08F11.5 7TM chemoreceptor, srw family H10D18.4 H10D18.4 Putative paralog of C. elegans H10D18.2 extracellular protein H10D18.5 H10D18.5 Protein of unknown function H10D18.6 H10D18.6 Putative paralog of C. elegans F47C10.6 UDP-glucuronosyltransferase H10E21.1 H10E21.1 Protein of unknown function H10E21.2 H10E21.2 Protein of unknown function, has low similarity to uncharacterized C. elegans ZC84.4 G-protein coupled receptor H10E21.3 nhr-80;H10E21.3 Member of the zinc finger, C4 type protein family with similarity to nuclear hormone receptors zinc finger protein H10E21.4 H10E21.4 Protein containing six EF hand domains, which are found in signaling, buffering or transport proteins, has a region of low similarity to calmodulin (C. albicans Cmd1p), which is involved in cell polarization, nuclear division, and chromosome maintenance calcium-binding protein H10E21.5 H10E21.5 Protein containing a C3HC4 type (RING) zinc finger, which may mediate protein-protein interactions zinc finger protein H11E01.1 H11E01.1 Protein of unknown function, has low similarity to uncharacterized C. elegans F55C9.9 H11E01.2 H11E01.2 Member of the sugar (and other) transporter family, has weak similarity to human SLC17A1, which is a sodium-dependent phosphate transporter that mediates organic anion transport at the renal apical membrane transporter H11E01.3 H11E01.3 Protein of unknown function, has a region of weak similarity to a region of S. cerevisiae Muc1p, which is cell surface flocculin that is required for invasive and pseudohyphal growth H11L12.1 H11L12.1 Protein of unknown function, has high similarity to uncharacterized C. elegans C27C7.1 H12C20.3 H12C20.3 Protein containing nuclear hormone receptor C4-type zinc finger and ligand-binding domains, has low similarity to hepatocyte nuclear factor 4 gamma (human HNF4G), which is involved in differential transcriptional regulation of HNF4-dependent genes nuclear hormone receptor H12C20.4 H12C20.4 Protein of unknown function, has high similarity to uncharacterized C. elegans H12C20.5 H12C20.5 H12C20.5 Protein of unknown function, has high similarity to uncharacterized C. elegans F59B1.3 H12C20.6 H12C20.6 Putative ortholog of C. elegans H12C20.3 gene product nhr-101 encodes a member of the nuclear hormone receptor family. H12D21.1 H12D21.1 Protein of unknown function, has weak similarity to C. elegans ZC412.7 H12D21.10 H12D21.10 Protein of unknown function H12D21.2 H12D21.2 Protein with strong similarity to C. elegans ZC412.9 gene product H12D21.3 H12D21.3 Protein of unknown function, has weak similarity to C. elegans ZC412.8 H12D21.4 H12D21.4 Protein containing a rhodanese-like domain, has weak similarity to thiosulfate sulfotransferase (rhodanese, human TST), which functions in detoxification of cyanide Rhodanese-like domain H12D21.5 H12D21.5 Protein with moderate similarity to C. elegans H12D21.4 H12D21.6 H12D21.6 Protein with weak similarity to H. sapiens TRO (trophinin) H12D21.7 H12D21.7 Protein with similarity to human and S. cerevisiae rhodanese (thiosulfate sulfurtransferase) proteins, has strong similarity to C. elegans H12D21.4 H12D21.8 H12D21.8 Protein of unknown function, putative paralog of C. elegans F25G6.1 H12D21.9 H12D21.9 Protein of unknown function H12I13.1 H12I13.1 Putative haspin-like protein kinase; has strong similarity to C. elegans ZK177.2 protein kinase H12I13.2 H12I13.2 Protein with moderate similarity to C. elegans F59E12.6 ubiquitin hydrolase H12I13.3 H12I13.3 Protein of unknown function, putative paralog of C. elegans C33E10.6 H12I13.4 fbf-1;H12I13.A;H12I13.4 RNA-binding protein involved in sex determination RNA-binding protein; fbf-1 encodes an RNA-binding protein that is one of 11 C. elegans members of the PUF family (Pumilio and FBF) of translational regulators; FBF-1 is nearly identical to FBF-2 with which it is largely redundant in regulating two aspects of germline development: 1)maintenance of stem cell proliferation, and 2)the hermaphroditic switch between spermatogenesis and oogenesis; in maintaining germline stem cells, the FBF proteins, acting through NOS-3, negatively regulate the activity of gld-1 mRNA, which encodes a translational repressor required for meiotic entry; in regulating the sperm-to-oocyte switch, the FBFs act downstream of GLD-3 to negatively regulate the activity of fem-3 mRNA, which encodes a novel protein required for germline sex determination; consistent with their role in germline development, FBF-1 and FBF-2 are expressed in the germline cytoplasm, becoming enriched in the mitotic region during the L4 larval and adult stages. H12I13.5 H12I13.5 Protein of unknown function H12I13.6 H12I13.6 Protein of unknown function H12I19.1 H12I19.1 Member of an uncharacterized protein family H12I19.2 H12I19.2 Member of an uncharacterized protein family H12I19.3 H12I19.3 Member of an uncharacterized protein family H12I19.4 H12I19.4 Member of an uncharacterized protein family H12I19.5 H12I19.5 Protein containing three DUF33 domains of unknown function, has moderate similarity to uncharacterized C. elegans F37C4.2 H12I19.6 H12I19.6 Member of the transposase family, which are required for excising and inserting mobile genetic elements, has very strong similarity to uncharacterized C. elegans F16D3.5 Transposase H13N06.2 H13N06.2 Protein containing a von Willebrand factor (vWF) type A domain von Willebrand factor type A domain H13N06.3 H13N06.3 Protein with strong similarity to C. elegans F19H8.1 gene product H13N06.4 H13N06.4 Protein with high similarity to sulfite oxidase (rat Suox), which binds molybdenum and catalyzes the conversion of sulfite to sulfate in the last step of cysteine and methionine degradation, contains molybdopterin oxidoreductase and heme-binding domains Heme-binding domain in cytochrome b5 and oxidoreductases, Oxidoreductase molybdopterin binding domain; H13N06.4 is orthologous to the human gene UNKNOWN (PROTEIN FOR MGC:12715) (SUOX; OMIM:602216), which when mutated leads to disease. H13N06.5 H13N06.5 Member of the ZIP zinc transporter family, which may be metal transporters, has high similarity to uncharacterized C. elegans T28F3.3 H13N06.6 H13N06.6 Member of the copper type II ascorbate-dependent monooxygenase family, has moderate similarity to dopamine beta-hydroxylase (human DBH), which is associated with noradrenergic denervation, adrenomedullary failure and orthostatic hypotension Copper type II, ascorbate-dependent monooxygenase; tbh-1 is orthologous to the human gene DOPAMINE BETA-HYDROXYLASE (DOPAMINE BETA-MONOOXYGENASE) (DBH; OMIM:223360), which when mutated leads to disease. H14A12.1 H14A12.1 Protein with strong similarity to C. elegans C24G7.3 gene product transposase H14A12.2 H14A12.2 Putative fumarase enzyme fumarase; fum-1 is orthologous to human FUMARASE (FH; OMIM:136850), which when mutated leads to fumarase deficiency; FUM-1A and FUM-1B are predicted to be mitochondrial. H14A12.3 H14A12.3 Protein of unknown function H14A12.4 mls-1;Ce-tbx-17;H14A12.4 Member of the T-box protein family involved in the specification of nonstriated muscle fates in the M lineage mls-1 encodes a T-box transcription factor orthologous to members of the Tbx1 subfamily of T-box transcription factors (OMIM:602054, mutations in human TBX1 are associated with the developmental disorder DiGeorge syndrome (DGS)/velocardiofacial syndrome (VCFS)); MLS-1 is required for fate specification of the eight nonstriated uterine muscle cells generated during postembryonic development, and ectopic expression of MLS-1 is sufficient for uterine muscle specification in other mesodermal lineages; mls-1 reporter gene expression is detected in uterine progenitors and differentiated uterine muscles, Type 2 vulval muscles, the left and right intestinal muscles, and the anal depressor muscle; mls-1 expression is positively regulated by the basic helix-loop-helix transcription factors HLH-8/Twist and HLH-2/Daughterless. H14A12.5 H14A12.5 Protein of unknown function H14E04.2 H14E04.2 Protein with moderate similarity to C. elegans Y46E12A.A gene product H14E04.4 H14E04.4 Protein of unknown function H14E04.A H14E04.5;H14E04.A Protein containing a cyclin N-terminal domain, has low similarity to cyclin C (human CCNC), which functions in transcription, cell-cell adhesion, and cell proliferation and may be associated with lymphoid malignancies H14E04.C H14E04.3;H14E04.C Protein of unknown function H14E04.F H14E04.1;H14E04.F Member of the ubiE or COQ5 methyltransferase family, has low similarity to S-adenosyl-L-methionine delta-24-sterol-C-methyltransferase (C. albicans Erg6p), which carries out methylation of zymosterol as part of the ergosterol biosynthesis pathway H14N18.1 unc-23;bag-2;vab-4;H14N18.1 Highly similar to mammalian BAG-2, BCL2-associated athanogene 2, a chaperone regulator H14N18.2 H14N18.2 Protein of unknown function H14N18.3 H14N18.3 Member of the transthyretin-like family, has moderate similarity to uncharacterized C. elegans ZC64.2 H14N18.4 H14N18.4 Member of the gamma-glutamyltransferase (tentative) protein family transpeptidase H15N14.1 H15N14.1 Protein containing four double-stranded RNA binding domains and two adenosine-deaminase (editase) domain, which deaminate adenosine residues on mRNA, has a region of weak similarity to a region of RNA-specific adenosine deaminase B1 (rat Adarb1) Double-stranded RNA binding motif (2 domains); adr-1 encodes, through alternative splicing, at least five isoforms of an adenosine deaminase that acts on RNA (ADAR); ADARs are RNA-editing enzymes that deaminate adenosines to create inosines in double-stranded RNA (dsRNA); adr-1 is expressed in embryos, most or all neurons (e.g., sensory neurons and cilia, the ventral nerve cord, motor neurons and interneurons) and in the developing (but not the adult) vulva; ADR-1 is required for ADAR activity in vivo, and for normal chemotaxis and vulval development; ADR-1 is also required (redundantly with ADR-2) to prevent the silencing of transgenes in somatic tissues by RNAi; ADR-1 (with ADR-2) may protect transgenic RNA from RNAi silencing by deaminating transgenic dsRNA; ADR-1 contains a glutamine/asparagine-rich domain, as well as two N-terminal double-stranded RNA-binding motifs. H16D19.3 H16D19.3 Putative ortholog of C. elegans T07D10.3 gene product H16D19.4 H16D19.4 Protein with moderate similarity to C. elegans F52G3.4 gene product H16O14.1 H16O14.1 Putative ortholog of H. sapiens DKFZP434D2135 (solute carrier family 12 (potassium/chloride transporters), member 6) H16O14.2 H16O14.2 Protein of unknown function H17B01.1 H17B01.1 Member of the sugar (and other) transporter family, has moderate similarity to facilitative glucose transporter 3 (human SLC2A3), which is a high-affinity glucose transporter that may provide glucose to regions of the brain with high metabolic activity sugar transporter H17B01.2 H17B01.2 Putative paralog of C. elegans Y51H7C_254.B, has similarity to collagen collagen H17B01.3 H17B01.3 Member of the class 2 lipase family, has low similarity to uncharacterized C. elegans T13B5.7 H17B01.4 H17B01.4 Protein of unknown function, has weak similarity to uncharacterized S. pombe Spac25h1.07p H18N23.1 H18N23.1 Protein of unknown function, has strong similarity to C. elegans B0403.1 H18N23.2 H18N23.2 Putative ortholog of C. elegans F15G10.1 gene product H19J13.1 H19J13.1 Protein of unknown function, has high similarity to uncharacterized C. elegans F45F2.7 H19M22.2 let-805;H19M22.1;H19M22.2 Putative cell adhesion protein required for movement and elongation during embryogenesis, has strong similarity to C. briggsae myotactin H19M22.3 H19M22.3 Putative matrix metalloprotease protease H19M22.4 H19M22.4 Protein of unknown function, has weak similarity to C. elegans Y76B12C_67.C H19N07.1 H19N07.1 Protein with high similarity to G1 to S phase transition 2 (mouse Gspt2), which adopt a beta barrel structure and may be a translation release factor, contains an elongation factor Tu domain 2, and elongation factor Tu GTP binding and C-terminal domains elongation factor H19N07.2 H19N07.2 Member of the ubiquitin carboxyl-terminal hydrolase family 2, contains two ubiquitin carboxyl-terminal hydrolases family 2 domains and two meprin and TRAF homology (MATH) domains, has low similarity to ubiquitin specific protease 7 (human USP7) ubiquitin carboxyl-terminal hydrolase; The H19N07.2 gene encodes a protein with a meprin-associated Traf homology (MATH) domain that may be involved in apoptosis. H19N07.3 H19N07.3 Protein of unknown function H19N07.4 H19N07.4;DGAT Acyl-CoA:diacylglycerol acyltransferase H19N07.4 encodes an integral membrane protein with acyl-CoA:diacylglycerol o-acyltransferase activity when expressed in yeast; H19N07.4 belongs to the MBOAT protein family, whose biochemically characterized members transfer fatty acids or acetate to membrane-associated hydroxyl-bearing substrates such as cholesterol, diacylglycerol, long-chain alcohols, or alginate; MBOAT proteins include MOM-1 and its Drosophila homolog PORCUPINE, involved in Wnt signalling; H19N07.4 has no obvious function in mass RNAi assays. H20E11.1 H20E11.1 Protein containing a DUF141 domain of unknown function, has low similarity to uncharacterized C. elegans C14C11.4 H20E11.2 H20E11.2 Protein of unknown function, has high similarity to uncharacterized C. elegans H20E11.3 H20E11.3 H20E11.3 Protein of unknown function, has high similarity to uncharacterized C. elegans H20E11.2 H20H17.1 H20H17.1 Protein of unknown function, has low similarity to uncharacterized C. elegans F57G4.3 H20J04.1 H20J04.1 Protein of unknown function, has weak similarity to C. elegans C38D9.5 H20J04.2 H20J04.2 Putative paralog of C. elegans H20J04_865.B H20J04.3 H20J04.3 Putative paralog of C. elegans H20J04_717.D (Member of the RNA helicase, DEAD-box protein family) H20J04.4 H20J04.4 Putative paralog of C. elegans H20J04_717.D (Member of the RNA helicase, DEAD-box protein family) helicase H20J04.5 H20J04.5 Protein with strong similarity to C. elegans H20J04_717.C H20J04.6 H20J04_717.A;H20J04.B;H20J04.6 Protein of unknown function H20J04.7 H20J04_865.A;H20J04.A;H20J04.7 Protein of unknown function, has moderate similarity to C. elegans C50E3.7 H20J04.8 H20J04.8 Putative ortholog of C. elegans H20J04_717.B gene product H20J18.1 H20J18.1 Protein with weak similarity to H. sapiens Hs.194785 (Homo sapiens 130 kD Golgi-localized phosphoprotein (GPP130) mRNA, complete cds) scd-1 encodes a novel protein with several regions that are extremely glutamine (Q) rich, interspersed with other residues (usually alanine); SCD-1 affects signalling by proteins in the DAF-7/transforming growth factor (TGF)-beta pathway (DAF-1, DAF-8, and DAF-14), and the Q-rich regions of SCD-1 protein may mediate epigenetic changes of stably heritable tertiary conformation. H21P03.1 H21P03.1 Protein with high similarity to endothelial differentiation-related factor 1 (human EDF1), which is a putative transcriptional coactivator that binds to human CALM1 in a calcium-dependent manner, member of the DNA binding helix-turn helix protein family Helix-turn-helix H21P03.2 H21P03.2 Protein of unknown function, has weak similarity to S. cerevisiae Qri2p H21P03.3 H21P03.3 Protein with strong similarity to C. elegans F53H8.4 gene product H22D07.1 H22D07.1 Member of the rhodopsin family of G protein-coupled receptors (GPCR), has a region of low similarity to a region of v1a vasopressin receptor (human AVPR1A), which is coupled to phospholipase_C through a pertussin toxin-insensitive G protein H22D14.1 H22D14.1 Protein containing a nuclear hormone receptor C4-type zinc finger domain, has a region of low similarity to a region of retinoic acid receptor beta (human RARB), which may be associated with hepatocellular carcinogenesis upon gene mutation Zinc finger, C4 type (two domains) H22K11.1 asp-3;H22K11.1 Probable aspartyl protease and an ortholog of human cathepsin D aspartyl protease; asp-3 encodes an aspartyl protease homolog that is required, in parallel with ASP-4 but downstream of CLP-1 and TRA-3, for degenerative (necrotic-like) cell death in neurons induced by mutations such as mec-4(d), deg-3(d), or gsa-1(gf). H22K11.2 H22K11.2 Member of the glycosyl hydrolases family 35 of beta-galactosidases, has moderate similarity to beta galactosidase 1 (mouse Glb1), which catalyzes cleavage of the terminal galactose from gangliosides, glycoproteins, and glycosaminoglycans glycosyl hydrolases H22K11.3 H22K11.3 Protein of unknown function H22K11.4 H22K11.4 Protein of unknown function H22K11.4 is orthologous to the human gene SARCOGLYCAN, ALPHA (50KD DYSTROPHIN-ASSOCIATED GLYCOPROTEIN) (SGCA; OMIM:600119), which when mutated leads to disease. H23L24.1 H23L24_11.E;H23L24.E;H23L24.1 Protein of unknown function H23L24.2 H23L24.2 Putative paralog of C. elegans H23L24_11.D H23L24.3 H23L24.3 Putative paralog of C. elegans H23L24_11.C H23L24.4 H23L24.4 Putative paralog of C. elegans H23L24_11.B 7tm_1 H23L24.6 H23L24.6 Protein of unknown function H23L24_11.A H23L24.5;H23L24_11.A Protein of unknown function, has low similarity to a region of poly (ADP-ribose) glycohydrolase (mouse Parg), which is required for turnover of polymeric ADP-ribose, may play a role in DNA repair, and inhibition blocks oxidative death of astrocytes H23N18.2 H23N18.2 Member of the UDP-glucuronosyltransferase protein family transferase H23N18.3 H23N18.3 Member of the UDP-glucuronosyltransferase protein family transferase H23N18.4 H23N18.C;H23N18.4 Protein containing a UDP-glucoronosyl and UDP-glucosyl transferase domain, has low similarity to UDP-glucuronosyltransferase 8 (UDP-galactose ceramide galactosyltransferase, rat Ugt8), which catalyzes the formation of galactosylceramide transferase H23N18.A H23N18.5;H23N18.A Protein of unknown function, has weak similarity to C. elegans Y52B11A.8 H23N18.D H23N18.1;H23N18.D Protein containing a UDP-glucoronosyl and UDP-glucosyl transferase domain, has weak similarity to UDP-glucuronosyltransferase 2B family member 5 (mouse Ugt2b5), which conjugates lipophilic aglycon substrates with glucuronic acid H24D24.1 H24D24.1 Protein of unknown function, has high similarity to uncharacterized C. elegans H24D24.2 7TM chemoreceptor, srw family H24D24.2 H24D24.2 Protein of unknown function, has high similarity to uncharacterized C. elegans H24D24.1 7TM chemoreceptor, srw family H24G06.1 H24G06.1 Protein containing multiple WD domains (WD-40 repeat), which may mediate protein-protein interactions, has a region of low similarity to a region of Jun N-terminal kinase-binding protein 1 (mouse Jnkbp1), which associates with Jun N-terminal kinases H24K24.1 H24K24.1 Protein with weak similarity to H. sapiens SETMAR (SET domain and mariner transposase fusion gene) H24K24.2 H24K24.2 Protein of unknown function, has strong similarity to C. elegans C33A12.12 H24K24.3 H24K24.3 Putative ortholog of S. cerevisiae SFA1 gene product (Long-chain alcohol dehydrogenase (ADH) with similarity to mammalian ADH class III) alcohol dehydrogenase H24K24.4 H24K24.4 Protein with moderate similarity to D. melanogaster CG3808 (CG3808 gene product) RNA-binding protein H24K24.5 H24K24.5 Putative ortholog of H. sapiens FMO5 (flavin containing monooxygenase 5) flavin-containing monooxygenase; fmo-15 encodes a flavin-containing monooxygenase (FMO) homologous to various human FMOs mutated in trimethylaminuria (OMIM:602079). H24O09.1 H24O09.1 Protein of unknown function, has moderate similarity to C. elegans T05E12.2 H24O09.2 H24O09.2 Protein of unknown function, has strong similarity to C. elegans F40F4.1 H25K10.1 H25K10.1 Member of the purple acid phosphatase family, which catalyze hydrolysis of phosphate esters, has weak similarity to a region of acid phosphatase PII (A. niger aphA), which is an acid-repressible metallo phosphoesterase H25K10.2 H25K10.2 Protein of unknown function, has weak similarity to C. elegans F56C3.1 H25K10.3 H25K10.3 Protein of unknown function, has weak similarity to uncharacterized C. elegans F53F1.9 G-protein coupled receptor, srv family H25K10.4 H25K10.4 Protein of unknown function, has strong similarity to uncharacterized C. elegans F38C2.1 H25K10.5 H25K10.5 Member of an uncharacterized protein family H25K10.6 H25K10.6 Member of an uncharacterized protein family H25K10.7 H25K10.7 Protein of unknown function, has moderate similarity to uncharacterized C. elegans T11F1.1 7TM chemoreceptor, srw family H25P06.1 H25P06.1 Member of the hexokinase family, which convert aldo- and keto-hexose sugars to hexose-6-phosphate, has moderate similarity to glucokinase (human GCK), which converts glucose to glucose-6-phosphate and is associated with diabetes mellitus Hexokinases H25P06.2 H25P06.2 Protein with high similarity to cyclin-dependent kinase 9 (human CDK9), which binds cyclin T to form the transcription elongation factor P-TEFb that hyperphosphorylates the RNA polymerase II subunit POLR2A, contains four protein kinase domains serine/threonine kinase (CDC2/CDKX subfamily) (2 domains); cdk-9 encodes an ortholog of the metazoan transcription elongation factor kinase CDK-9; it is required for general expression of early embryonic genes, and thought (in conjunction with partners such as cyclin T) to form a transcription factor (P-TEFb) that which prevents transcription from stalling in vitro. H25P06.4 H25P06.4 Protein of unknown function, has a region of low similarity to a region of calpain I (rat Capn1), which is a catalytic subunit of the calcium-dependent cysteine (thiol) protease mu-calpain H25P19.1 H25P19.1 Protein with moderate similarity to C. elegans T03D3.5 gene product H26D21.1 hus-1;H26D21.1 Believed to function in a DNA damage checkpoint pathway, has similarity to S. pombe HUS1, a cell cycle checkpoint protein H26D21.2 msh-2;H26D21.2 Protein containing a MutS family N-terminal DNA binding domain, has low similarity to mutS homolog 2 (human MSH2), which is a mismatch repair protein involved in transcription coupled repair and is associated with hereditary nonpolyposis colorectal cancer DNA mismatch repair protein; The msh-2 gene encodes a DNA mismatch repair protein homolog that is orthologous to human MSH2 (OMIM:120435); mutation of the human MSH2 gene leads to hereditary non-polyposis colon cancer (OMIM:120436). H27A22.1 H27A22.1 Protein with moderate similarity to glutaminyl-peptide cyclotransferase (glutaminyl cyclase, human QPCT), which is expressed in the pituitary and downregulated in lens epithelium during oxidative stress guanylate cyclase H27C11.1 nhr-97;H27C11.1 Protein containing nuclear hormone receptor C4-type zinc finger and ligand-binding domains, has low similarity to a region of retinoid X receptor gamma (human RXRG), which is a transcriptional coactivator that binds 9-cis retinoic acid Zinc finger, C4 type (two domains) ; Ligand-binding domain of nuclear hormone receptors H27D07.1 H27D07.1 Protein of unknown function, has strong similarity to uncharacterized C. elegans C44C3.2 H27D07.2 H27D07.2 G protein-coupled receptor of unknown function; has similarity to C. elegans H05B21.3 and H05B21.4, has weak similarity to human proteinase-activated receptor 7TM chemoreceptor, srw family H27D07.3 H27D07.3 Protein of unknown function, has high similarity to uncharacterized C. elegans H05B21.4 7TM chemoreceptor, srw family H27D07.4 H27D07.4 Protein with similarity to G protein-coupled receptors in the C-terminal region 7TM chemoreceptor, srw family H27D07.5 H27D07.5 G protein-coupled receptor of unknown function, no homolog found in human or D. melanogaster 7TM chemoreceptor, srw family H27D07.6 H27D07.6 Protein of unknown function, putative paralog of C. elegans C44C3.9 7TM chemoreceptor, srh family H27M09.1 H27M09.1 Putative ortholog of H. sapiens ABS (DEAD-box protein abstrakt) helicase H27M09.2 H27M09.2 Putative ortholog of D. melanogaster CG11979 (CG11979 gene product) RNA polymerase H27M09.3 H27M09.3 Protein with weak similarity to C. elegans nmy-1 (Myosin family member) H27M09.4 H27M09.4 Putative paralog of C. elegans F14H12.1 H27M09.5 H27M09.5 Putative paralog of C. elegans Y119C1B.J H28G03.1 H28G03.1 Protein containing six RNA recognition motifs (RRM, RBD, or RNP), has moderate similarity to a region of heterogeneous nuclear ribonucleoprotein A1 (human HNRPA1), which is an RNA-binding protein involved in RNA splice site selection and mRNA export RNA binding protein H28G03.2 H28G03.2 Protein of unknown function, has weak similarity to C. elegans ZC477.8 H28G03.3 H28G03.3 Protein of unknown function intermediate filament protein H28G03.4 H28G03.4 Protein of unknown function, has a region of low similarity to C. elegans C01B12.6, which is a transposase transposase H28G03.6 H28G03.6 Protein containing a PH (pleckstrin homology) domain, has similarity to human and D. melanogaster SBF proteins (SET domain binding factors), has similarity over the N-terminus to human myotubularin-related proteins H28O16.1 H28O16.1 Protein with high similarity to ATP synthase H+ transporting mitochondrial F1 complex alpha subunit 1 (mouse Atp5a1), contains ATP synthase subunit alpha and beta C-terminal and ATP synthase alpha or beta family nucleotide-binding and beta-barrel domains ATP synthase alpha and beta subunits, ATP synthase Alpha chain, C terminal H28O16.2 H28O16.2 Protein of unknown function, has weak similarity to a region of microspherule protein 1 (human MCRS1), which interacts with human NOL1, and may be involved in nucleolar size control or act as a regulator of HSV1 transcription factor human ICP22 expression H30A04.1 eat-20;crl-1;H30A04.1 Protein of unknown function; may be membrane binding; contains three EGF-like domains EGF-like domain (3 domains); eat-20 encodes a paralog of the C. elegans and Drosophila genes crb-1 and crumbs, expressed in pharynx, head neurons, hypodermis, and developing embryos. H31G24.1 H31G24.1 Protein with weak similarity to C. elegans cyk-1 (Formin homology (FH) family member required for completion of cytokinesis) H31G24.3 H31G24.3 Protein of unknown function, has strong similarity to C. elegans Y43E12A.3 H31G24.4 H31G24.4 Putative paralog of C. elegans Y43E12A.1 cyclin H32K16.1 H32K16.1 Member of the transmembrane amino acid transporter (permease) family, has low similarity to lysosomal amino acid transporter 1 (rat Lyaat1), which transports gamma-aminobutyric acid, glycine, L-alanine, L-proline, and D-proline H34C03.1 H34C03.1 Protein of unknown function H34C03.2 H34C03.2 Member of the ubiquitin carboxyl-terminal hydrolase family 2, contains a ubiquitin carboxyl-terminal hydrolases family 2 domain, has low similarity to ubiquitin specific protease 4 (ubiquitous nuclear protein human, human USP4) ubiquitin carboxy-terminal hydrolase H34I24.1 H34I24.1 Protein of unknown function, has weak similarity to C. elegans E02H9.2 H34I24.2 H34I24.2 Putative ortholog of C. elegans Y71H2AR.C gene product H34P18.1 H34P18.1 Protein of unknown function, has high similarity to uncharacterized C. elegans T15B7.12 H35B03.1 H35B03.1 Protein of unknown function H35N03.1 H35N03.1 Protein containing a neurotransmitter-gated ion-channel ligand binding domain, has low similarity to the beta 3 subunit of gamma-amino butyric acid A receptor (human GABRB3), which is the major neuronal inhibitory neurotransmitter receptor ion channel H35N09.1 H35N09.1 Protein of unknown function, has weak similarity to C. elegans C50H11.8 H35N09.2 H35N09.2 Protein of unknown function H36L18.1 H36L18.1 Member of the matrixin family, contains three hemopexin domains, which may facilitate binding to various proteins and molecules, has low similarity to a region of matrix metalloproteinase 24 (human MMP24), which is associated with Alzheimer's disease matrix metalloprotease H36L18.2 H36L18.2 Protein of unknown function H37A05.1 H37A05.1 Protein with low similarity to mouse Lpin1, which is involved in developmental processes H37A05.2 H37A05.2 Protein containing a DUF227 domain of unknown function, has moderate similarity to uncharacterized C. elegans F58B4.5 H37N21.1 H37N21.1 Protein with weak similarity to human MAP/ERK kinase kinase 3 (MEKK3), has similarity to C. elegans protein kinase C46C2.1 tyrosine-protein kinase H38K22.1 H38K22.1 Protein with weak similarity to androgen-induced prostate proliferative shutoff associated protein 3 (human AS3), which inhibits cell proliferation and is upregulated during androgen-induced proliferative shutoff evl-14 encodes a homolog of the yeast sister cohesion protein Pds5p that functions during both mitosis and meiosis and is implicated in the maintenance of sister chromatid cohesion in late prophase, and affects vulval morphology, meiotic germline development, embryonic and larval viability, fertility, and cell divisions in the germ line as well as in vulval and somatic gonad lineages; some of the defects, such as somatic gonad defects, are due at least partially to cell division defects. H38K22.2 H38K22.2 Protein of unknown function, has moderate similarity to uncharacterized RP42 (human RP42) H38K22.3 H38K22.3 Protein containing a steroid binding domain H38K22.4 H38K22.4 Protein of unknown function H38K22.5 gly-6;H38K22.5 N-acetylgalactosaminyltransferase Glycosyl transferases H39E20.1 H39E20.1 Protein of unknown function H39E23.1 par-1;zyg-14;H39E23.1 Serine/threonine protein kinase required for cytoplasmic partitioning during cleavage of early embryonic cells; has strong similarity to human EMK1 and MARK3 protein kinases, which are involved in microtubule-related events serine/threonine kinase (KIN1/SNF1/Nim1 subfamily) H40L08.1 H40L08.1 Protein containing a UBA (ubiquitin associated) or TS-N domain H40L08.3 H40L08.3 Protein of unknown function H41C03.1 H41C03.1 Protein containing a CRAL-TRIO domain, has low similarity to SEC14-like 2 (human SEC14L2), which is an alpha-tocopherol-binding protein that translocates from the cytosol to the nucleus and activates transcription H41C03.2 H41C03.2 Member of the lipase class 3 family, which are a subset of lipolytic enzymes that hydrolyze ester linkages of triglycerides, has low similarity to uncharacterized C. elegans T10B5.7 H41C03.3 H41C03.3 Member of the core-2 or I-branching enzyme family, which form blood group I-antigens or O-glycan side-chains, has weak similarity to human GCNT1, which forms O-glycan branched structures and is involved in Wiskott-Aldrich syndrome and multiple sclerosis H42K12.2 H42K12.2 Protein of unknown function H42K12.3 H42K12.3 Protein containing two PAN domains, which may mediate protein-protein or protein-carbohydrate interactions H43E16.1 H43E16.1 Protein of unknown function, has weak similarity to uncharacterized mouse S3-12, which is a plasma membrane associated protein that is induced during adipocyte differentiation H43I07.1 H43I07.1 Protein of unknown function H43I07.2 H43I07.2 Protein of unknown function, similar to glycosyl transferases transferase HOT-3 hot-3 Ly-6-related protein HOT-4 hot-4 Ly-6-related protein HSP12.3 F38E11.1;hsp12.3 Member of the Hsp20 or alpha crystallin family, has moderate similarity to a region of alpha-B crystallin (mouse Cryab), which functions as a molecular chaperone and modulates components of cell remodeling and apoptosis HSP17.5 F52E1.7;hsp17.5 Member of the Hsp20 or alpha crystallin family, has low similarity to alpha-B crystallin (mouse Cryab), which functions as a molecular chaperone and modulates components of cell remodeling and apoptosis ICP-1 icp-1 Protein with similarity to human INCENP inner centromere protein JC8.10 JC8.10 Protein with similarity to inositol polyphosphate phosphatase catalytic domain Inositol polyphosphate phosphatase, catalytic domain homologues; unc-26 encodes synaptojanin, a polyphosphoinositide phosphatase orthologous to human synaptojanin 1 (OMIM:604297, 309000, which when mutated leads to Lowe oculocerebrorenal syndrome); UNC-26 is required for normal locomotion, pharyngeal pumping, and defecation, and specifically, appears to function in multiple steps of synaptic vesicle recycling; UNC-26 may also play a role in cytoskeletal organization. JC8.11 JC8.11 Protein with strong similarity to C. elegans T23B5.1 gene product JC8.12 JC8.12 Protein of unknown function JC8.13 JC8.13 Protein of unknown function JC8.2 JC8.2 Protein containing five WD domains (WD-40 repeat), which may mediate protein-protein interactions, has moderate similarity to uncharacterized periodic tryptophan protein 1 (human PWP1), which may be involved in cell proliferation and transcription JC8.3 rpl-12;JC8.3 Member of the ribosomal protein L12 protein family Ribosomal protein L11; rpl-12 encodes a large ribosomal subunit L12 protein required in mass RNAi assays for embryonic viability, fertility, normally rapid growth, and general health; the rpl-12 transcription unit has a nonsense transcript that is up-regulated in vivo by smg[-] mutations, indicating that rpl-12 is a natural substrate for SMG-mediated nonsense suppresssion; several other natural mRNA substrates of SMG suppression (e.g., rpl-3, rpl-7, rpl-10) have protein products that are involved in translation. JC8.4 JC8.4 Protein containing a cytidine deaminase zinc-binding domain, has moderate similarity to a region of S. cerevisiae Tad2, which is a subunit of tRNA[Ala]-specific adenosine deaminase JC8.5 JC8.5 Protein of unknown function, has high similarity to a region of S. cerevisiae Cox11p, which is required for heme A synthesis JC8.6 JC8.6 Protein of unknown function, has a region of moderate similarity to a region of tesmin (mouse Mtl5), which is a cysteine-rich protein with a metallothionein-like motif that is expressed specifically in spermatocytes and may be required for male fertility JC8.7 JC8.7 Protein of unknown function JC8.8 JC8.8 Member of the transthyretin-like family, has high similarity to uncharacterized C. elegans C56A3.2 Transthyretin-like family K01A11.1 K01A11.1 Protein of unknown function K01A11.2 K01A11.2 Protein of unknown function, has low similarity to uncharacterized C. elegans F22B7.9 Yeast YIL-0 like protein K01A11.3 K01A11.3 Protein containing a ubiquitin carboxyl-terminal hydrolases family 2 domain K01A11.4 K01A11.4 Member of the ion transport family, contains one ankyrin (Ank) repeat, has weak similarity to transient receptor potential channel 6 (human TRPC6), which is a non-voltage sensitive cation channel calmodulin-binding trp1 like protein K01A12.1 K01A12.1 Protein of unknown function K01A12.2 K01A12.2 Protein of unknown function K01A12.3 K01A12.3 Protein of unknown function K01A2.1 K01A2.1 Protein of unknown function K01A2.1 is orthologous to the human gene SARCOGLYCAN, BETA (43KD DYSTROPHIN-ASSOCIATED GLYCOPROTEIN) (SGCB; OMIM:600900), which when mutated leads to disease. K01A2.10 K01A2.10 Protein with weak similarity to C. elegans let-502 (Serine/threonine protein kinase required for embryonic elongation) K01A2.11 K01A2.11 Protein containing ten EF hand domains, which are found in signaling, buffering or transport proteins calcium-binding protein K01A2.2 K01A2.2 Protein of unknown function, has weak similarity to C. elegans F15B9.2 K01A2.3 K01A2.3 Putative ortholog of C. elegans K01A2.4 gene product K01A2.5 K01A2.5 Member of the alpha or beta hydrolase fold family, has low similarity to biphenyl hydrolase-like (human BPHL), which is a putative serine hydrolase that may catalyze hydrolysis of p-nitrophenylbutyrate and may be involved in xenobiotic metabolism K01A2.6 K01A2.6 Protein of unknown function, has weak similarity to C. elegans ZK512.7 K01A2.7 K01A2.7 Protein containing two collagen triple helix repeats and a nematode cuticle collagen N-terminal domain, has a region of high similarity to a region of C. elegans BLI-1, which is a likely collagen involved in embryogenesis and morphogenesis and chemotaxis cuticular collagen K01A2.8 K01A2.8 Protein of unknown function, has strong similarity to uncharacterized C. elegans K01A2.9 K01A2.9 K01A2.9 Protein of unknown function, has strong similarity to uncharacterized C. elegans K01A2.8 K01A6.1 K01A6.1 Protein containing five PDZ, DHR, or GLGF domains, which are found in signaling proteins, and two WW domains, has low similarity to activin receptor-interacting protein 1 (mouse Acvrip1), which inhibits activin-induced transcriptional activity K01A6.2 K01A6.2 Protein with similarity to membrane-associated guanylate kinases (MAGUKs); has moderate similarity to the N-terminus of H. sapiens BAIAP1 gene product, BAI1-associated protein 1 membrane-associated guanylate kinase homolog (MAGUK) K01A6.3 K01A6.3 Protein of unknown function K01A6.4 K01A6.4 Protein of unknown function K01A6.5 K01A6.5 Protein of unknown function, has moderate similarity to C. elegans F46B6.10 K01A6.6 K01A6.6 Protein with similarity to G protein-coupled receptors of C. elegans K01B6.1 K01B6.1 Protein containing a formin homology 2 domain, which are found in proteins that control rearrangements of the actin cytoskeleton Zinc-finger motif C2H2 type; K01B6.1 encodes a protein with a zinc-finger domain, a formin homology 2 domain, and a glutamine/asparagine-rich domain; it is dispensable, in RNAi assays, for viability and gross anatomy. K01B6.2 K01B6.2 Protein with moderate similarity to C. elegans Y43B11AL.2 gene product K01B6.3 K01B6.3 Protein of unknown function K01C8.1 K01C8.1 Member of the pyridoxal phosphate dependent enzyme beta family, contains an ACT domain, has a region of low similarity to serine racemase (human SRR), which catalyzes the racemisation of L-serine to D-serine in a pyridoxal 5'-phosphate-dependent manner threonine dehydratase; This gene encodes a protein predicted by Eisenberg and coworkers, with 52% accuracy, to be mitochondrial. K01C8.10 cct-4;K01C8.10 Putative T-complex chaperonin, has strong similarity to T-complex chaperonins of human, D. melanogaster, S. cerevisiae, and C. elegans, member of the TCP-1/cpn60 chaperonin protein family T-complex protein; cct-4 encodes a putative T complex chaperonin that affects fertility and body morphology and intergrity; expressed in touch receptor neurons. K01C8.2 K01C8.2 Member of the EGF-repeat protein family K01C8.3 K01C8.3 Protein containing two pyridoxal-dependent group II decarboxylase conserved domains, which bind pyridoxal-phosphate groups, has a region of high similarity to dopa decarboxylase (aromatic L-amino acid decarboxylase, mouse Ddc) aromatic-L-amino-acid decarboxylase K01C8.4 K01C8.4 Protein with moderate similarity to C. elegans K01C8.3 gene product K01C8.5 K01C8.5 Protein of unknown function gei-14 encodes a novel protein that interacts with GEX-3 in yeast two-hybrid assays. K01C8.6 K01C8.6 Protein of unknown function This gene encodes a protein predicted by Eisenberg and coworkers, with 52% accuracy, to be mitochondrial. K01C8.7 K01C8.7 Member of the mitochondrial carrier protein family of membrane transporters, has moderate similarity to human LOC81034, which is a mitochondrial folate transporter that facilitates the transport of folates from the cytosol into the mitochondrial matrix Mitochondrial carrier proteins K01C8.8 K01C8.8 Protein of unknown function K01C8.9 K01C8.9 Putative ortholog of S. cerevisiae Yer006p, a protein of unknown function GTP-binding protein; nst-1 encodes a homolog of human FLJ10613 and nucleostemin (OMIM:608011); nucleostemin is a nucleolar protein found in stem cells that is required in quantitatively correct amounts (neither too little nor too much) for continued cell division and survival by stem cells or transformed cells; NST-1 is required in mass RNAi assays for normally rapid growth, larval viability, and normal body morphology and pigmentation; it is thus possible that NST-1 acts in the nucleolus to maintain cell proliferation. K01D12.1 K01D12.1 Member of the domain of unknown function DUF13 family, has high similarity to uncharacterized C. elegans C33H5.1 K01D12.10 K01D12.10 Protein of unknown function K01D12.11 K01D12.11 Member of the glutathione S-transferase protein family glutathione S-transferase K01D12.12 K01D12.12 Protein of unknown function, has strong similarity to uncharacterized C. elegans K01D12.11 glutathione S-transferase K01D12.13 K01D12.13 Protein containing a glutathione S-transferase C-terminal domain, which may be involved in conjugation of reduced glutathione to various targets, has high similarity to uncharacterized C. elegans K01D12.12 glutathione S-transferase K01D12.14 K01D12.14 Protein containing a glutathione S-transferase C-terminal domain, which may be involved in conjugation of reduced glutathione to various targets, has high similarity to uncharacterized C. elegans K01D12.11 K01D12.15 K01D12.15 Protein of unknown function, has weak similarity to C. elegans K01D12.7 K01D12.2 K01D12.2 Protein of unknown function, has high similarity to uncharacterized C. elegans Y87G2A.12 K01D12.3 K01D12.3 Member of the domain of unknown function DUF13 family, has high similarity to uncharacterized C. elegans C13A2.9 K01D12.4 twk-12;K01D12.4 Member of the 4 TM potassium channel protein family potassium channel protein K01D12.5 K01D12.5 Protein of unknown function K01D12.6 K01D12.6 Protein of unknown function K01D12.7 K01D12.7 Protein of unknown function, has weak similarity to C. elegans K01D12.15 K01D12.8 K01D12.8 Protein of unknown function, has high similarity to uncharacterized C. elegans K01D12.9 K01D12.9 K01D12.9 Protein of unknown function, has weak similarity to C. elegans K01D12.8 K01G12.2 K01G12.2 Protein of unknown function, has weak similarity to C. elegans K01G12.3 K01G12.3 K01G12.3 Protein with strong similarity to C. elegans F02H6.2 K01G5.1 K01G5.1;3K846 Putative DNA-binding protein, has strong similarity to human ZNF183 protein (Hs.64794, isolated from an infant brain cDNA library) Zinc finger, C3HC4 type (RING finger) K01G5.10 K01G5.10 Protein of unknown function K01G5.2 hpl-2;K01G5.2 Heterochromatin protein 1 family protein, required for vulval development and germ line silencing, has similarity over the N-terminus to human chromobox homologs CBX1, CBX3, and CBX5 'chromo' (CHRromatin Organization MOdifier) domain; The hpl-2 gene encodes a homolog of heterochromatin protein 1 (HP1) which is required for germline function, silencing of transgenes in the germline, and vulval development. K01G5.3 K01G5.3 Putative ortholog of C. elegans C38D4.1 gene product K01G5.4 K01G5.4 Ran, GTP-binding protein of the ras superfamily possibly involved in trafficking through the nuclear pore; putative ortholog of S. cerevisiae Gsp1p and Gsp2p and putative ortholog of human androgen receptor associated protein ARA24 GTP-binding protein K01G5.5 K01G5.5 Possible ortholog of S. cerevisiae (Cbf5p) and D. melanogaster (Nop60B) nucleolar ribosomal processing proteins, possible ortholog of human DKC (associated with X-linked dyskeratosis congenita) centromere/microtubule binding protein; The K01G5.5 gene encodes an ortholog of human DYSKERIN (DKC1; OMIM:300126), which when mutated leads to X-linked dyskeratosis congenita (OMIM:305000); the K01G5.5 protein is predicted to be mitochondrial with 68% accuracy. K01G5.6 rib-2;K01G5.6 alpha-1,4-N-Acetylglucosaminyl transferase, thought to be involved in the initiation and elongation reactions of heparan sulfate biosynthesis MULTIPLE EXOSTOSES HOMOLOG 2; The rib-2 gene encodes an ortholog of human EXT2, which when mutated leads to hereditary multiple exostoses, type II (OMIM:133701). K01G5.7 K01G5.7 Protein with strong similarity to beta tubulin (C. elegans BEN-1), member of the tubulin-FtzA family, which are involved in polymer formation tubulin beta-chain; This gene encodes a homolog of mammalian beta-tubulin (TUBB) that is expressed at high levels in the germline; TBB-1 is redundant for embryonic viability, due to its paralog TBB-2. K01G5.8 K01G5.8 Protein of unknown function, has strong similarity to uncharacterized C. elegans K01G5.8 K01G5.9 K01G5.9 Protein with low similarity to uncharacterized S. pombe Spac823.09cp K01H12.1 K01H12.1 Protein of unknown function, has high similarity to uncharacterized S. pombe Spac8f11.02cp K01H12.1 encodes a small protein conserved in diverse eukaryotes, with a CSL motif (a probable zinc finger, sometimes found associated with the N-terminal domain of DnaJ protein); K01H12.1 is probably a small subunit or ancillary protein of RNA polymerase II Elongator or of a hypothetical diphthamide synthase complex; K01H12.1 is orthologous to to mammalian DESR1 (diphtheria toxin and Pseudomonas exotoxin A sensitivity required gene 1) and S. cerevisiae KTI11; DESR1, and probably KTI11, enables the first step in posttranslational modification of histidine to dipthamide; K01H12.1 has no obvious function in mass RNAi assays. K01H12.2 K01H12.2 Protein with high similarity to heart-skeletal muscle adenine nucleotide translocator (mouse Slc25a4), which is required for heart, brain, and muscle metabolism, member of the mitochondrial carrier protein family of membrane transporters ADP/ATP carrier protein K01H12.3 nhr-38;K01H12.3 Protein containing a nuclear hormone receptor C4-type zinc finger domain, has a region of moderate similarity to a region of nuclear receptor subfamily 5 group A member 2 (rat Nr5a2), which is a transcriptional activator of several liver specific genes Zinc finger, C4 type (two domains) K01H12.4 K01H12.4 Protein of unknown function K02A11.1 K02A11.1 Protein containing ten ankyrin (Ank) repeats, has moderate similarity to the regulatory subunit of protein phosphatase 1 (mouse Ppp1r16a), which inhibits protein phosphatase 1 activity toward phosphorylase, myosin light chain, and myosin ankyrin motifs K02A11.2 K02A11.2 Protein of unknown function, has strong similarity to C. elegans B0379.2 K02A11.3 K02A11.3 Protein with moderate similarity to serine protease 22 (placental protein 11, human P11), which is a serine protease that may be useful as a diagnostic marker for ovary adenocarcinoma and breast carcinoma placental protein 11 K02A2.1 K02A2.1 Member of the dienelactone hydrolase family, has high similarity to uncharacterized C. elegans D1022.5 K02A2.2 K02A2.2 Protein of unknown function, has high similarity to uncharacterized C. elegans F13G3.2 7TM chemoreceptor, srd family K02A2.3 K02A2.3 Protein with moderate similarity to solute carrier family 12 member 4 (mouse Slc12a4), which is a potassium-chloride cotransporter that mediates chloride-dependent cell-swelling activated potassium effux and is likely involved in cell volume regulation Bumetanide-sensitive Na-K-C1 cotransporter K02A2.5 K02A2.5 Protein of unknown function K02A2.6 K02A2.6 Member of the reverse trancriptase family, which are RNA-dependent DNA polymerases, contains a retroviral integrase core domain and a zinc knuckle domain, has strong similarity to uncharacterized C. elegans T03F1.4 POL Polyprotein (reverse transcriptase) K02A4.1 ECA39;K02A4.1 Member of the transaminase protein family twt1 like protein; eca-39 encodes a branched-chain amino acid aminotransferase that, by homology, is predicted to catalyze the first reaction in the catabolism of essential branched-chain amino acids such as leucine, isoleucine, and valine; in C. elegans, large-scale RNA-mediated interference (RNAi) screens indicate that eca-39 activity is required for embryonic and larval development. K02A4.2 gpc-1;K02A4.2 Member of the G protein gamma subunit protein family guanine nucleotide-binding protein gamma subunit; The gpc-1 gene encodes a heterotrimeric guanine nucleotide-binding protein gamma subunit, expressed specifically in sensory neurons, that is involved in taste adaptation. K02A6.1 K02A6.1 Protein of unknown function K02A6.2 K02A6.2 Protein of unknown function K02A6.3 K02A6.3 Protein containing an F-box domain, which serve as a link between a target protein and a ubiquitin-conjugating enzyme This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins. K02B12.1 ceh-6;K02B12.1 POU domain homeodomain transcription factor, has similarity over 260 amino acids to human POU3F4 homeodomain transcription factor, has similarity over 168 amino acids to D. melanogaster VVL (ventral veins lacking) homeodomain transcription factor Homeobox domain, Pou domain - N-terminal to homeobox domain; ceh-6 encodes a POU family homeodomain protein, homologous to human POU3F4 (OMIM:304400, mutated in conductive deafness 3) that affects embryonic viability, locomotion, and molting, and that regulates ectodermal and excretory function; CEH-6 is expressed dynamically during development and expression includes neurons, the excretory cell, and ectodermal cells. K02B12.2 K02B12.2 Protein of unknown function K02B12.3 K02B12.3 Protein containing three WD domains (WD-40 repeat), which may mediate protein-protein interactions, has weak similarity to prolactin regulatory element binding protein (human PREB), which is a transcriptional activator that may have a role in development WD domain, G-beta repeat K02B12.4 K02B12.4 Protein with strong similarity to human POU3F4 K02B12.5 K02B12.5 Protein containing three ankyrin (Ank) repeats, has a region of low similarity to a region of NF-kappaB inhibitor-like 2 (human NFKBIL2), which inhibits DNA binding of NFKB1-RELA NF-kappaB heterodimers and NFKB1 homodimers ankyrin motif K02B12.6 K02B12.6 Protein of unknown function K02B12.7 K02B12.7 Putative GTPase-activating protein, has similarity to D. melanogaster GTPase-activating protein 69C (GAP69C) ADP-ribosylation factor 1-directed GTPase activating protein K02B12.8 K02B12.8 Protein with moderate similarity to C. elegans D1081.9 gene product K02B2.1 K02B2.1 Protein with high similarity to 6-phosphofructo-2-kinase (human PFKFB3), which synthesizes and degrades fructose-2,6-bisphosphate and thus regulates glycolysis, member of the phosphoglycerate mutase and 6-phosphofructo-2-kinase families 6-phosphofructo-2-kinase K02B2.3 K02B2.3 Protein of unknown function, has low similarity to uncharacterized human FLJ20647 K02B2.4 opu-7;inx-7;K02B2.4 Member of the integral membrane innexin family, which are involved in the formation of gap junctions, has low similarity to C. elegans UNC-9, which is required for normal locomotion K02B2.5 K02B2.5 Protein with moderate similarity to ribosomal protein S25A (S. cerevisiae Rps25ap), which is a structural protein of the ribosome that is involved in protein biosynthesis ribosomal protein; rps-25 encodes a small ribosomal subunit S25 protein. K02B2.6 K02B2.6 Protein with moderate similarity to C. elegans K09F6.6 gene product K02B7.1 K02B7.1 Protein of unknown function, has strong similarity to uncharacterized C. elegans W03G1.4 K02B7.2 K02B7.2 Protein of unknown function, has strong similarity to uncharacterized C. elegans W03G1.3 K02B7.3 K02B7.3 Protein of unknown function K02B9.1 K02B9.1 Putative isocitrate lyase isocitrate lyase like K02B9.2 K02B9.2 Putative paralog of C. elegans K02B9.1 which encodes a putative isocitrate lyase MYB-related protein like K02B9.3 K02B9.3 Protein of unknown function K02B9.4 elt-3;K02B9.4 GATA-binding factor; required for hypodermal cell differentiation GATA-binding transcription factor like; The elt-3 gene encodes a GATA transcription factor expressed in the embryonic hypodermis; specifically, it is expressed in expressed in all of the major hypodermal cells except the lateral seam cells. K02C4.2 K02C4.2 Protein of unknown function K02C4.3 K02C4.3 Member of the ubiquitin carboxyl-terminal hydrolase family 2, contains a ubiquitin carboxyl-terminal hydrolases family 2 domain, has a region of weak similarity to a region of ubiquitin specific protease 25 (human USP25), which is a ubiquitin hydrolase ubiquitin carboxyl-terminal hydrolase K02C4.4 K02C4.4 Protein containing a LIM domain, which may mediate protein-protein interactions, has a region of low similarity to a region of kyphoscoliosis (mouse Ky), which is critical for muscle growth and function and for neuromuscular junction maturation LIM domain; ltd-1 encodes a protein with LIM and transglutaminase domains; LTD-1 is homologous to the mouse KY protein (MGI:96709, mutated in kyphoscoliosis), and to the HILLARIN protein of Hirudo medicinalis, found at axon hillocks; ltd-1 is expressed in hypodermal cells from the twofold stage embryo to adulthood, but has no obvious function in mass RNAi assays. K02D10.1 K02D10.1 Member of the haloacid dehalogenase or epoxide hydrolase family, has a region of moderate similarity to S. pombe Pho2p, which is a specific p-nitrophenylphosphatase 4-NITROPHENYLPHOSPHATASE K02D10.2 K02D10.2 Protein of unknown function K02D10.3 K02D10.3 Protein of unknown function K02D10.4 K02D10.4 Protein of unknown function, has weak similarity to C. elegans T20F7.2 K02D10.5 K02D10.5 Member of the synaptosome-associated protein 25 kD (SNAP-25) family, which are components of SNARE complexes synaptosomal associated protein K02D3.1 K02D3.1 Protein of unknown function, has moderate similarity to C. elegans T22F7.4 K02D3.2 K02D3.2 Protein containing a START (Steroidogenic Acute Regulatory protein) domain, which is a lipid-binding domain in StAR, HD-ZIP and signalling proteins K02D7.1 K02D7.1 Protein with high similarity to nucleoside phosphorylase (purine nucleoside phosphorylase, human NP), which acts in the purine salvage pathway and is associated with severe combined immunodeficiency, member of the purine phosphorylases family 2 phosphorylase; K02D7.1 is orthologous to the human gene PURINE NUCLEOSIDE PHOSPHORYLASE (NP; OMIM:164050), which when mutated leads to disease. K02D7.2 K02D7.2 Protein containing six C2H2 type zinc finger domains, which bind nucleic acids, has high similarity to a region of slug (human SNAI2), which is a transcriptional repressor that may repress basal and activator-mediated transcription zinc finger protein K02D7.3 K02D7.3 Protein containing two collagen triple helix repeats and one nematode cuticle collagen N-terminal domain, has a region of high similarity to a region of the alpha 1 subunit of type II collagen (rat Col2a1), which may be involved in cartilage development cuticular collagen K02D7.4 K02D7.4 Protein of unknown function Uncloned locus that affects the length of the defecation cycle and genetically interacts with clk-1 with respect to defecation cycle length, and also with respect to the clk-1- dependent adjustment of defecation cycle length to temperature. K02D7.5 K02D7.5 Member of the MtN3-saliva family, which contain a region of two transmembrane helices, has moderate similarity to uncharacterized C. elegans C54F6.4 K02D7.6 K02D7.6 Protein with weak similarity to C. elegans T24A6.15 gene product K02E10.1 K02E10.1 Member of the Ras superfamily of GTP binding proteins, has moderate similarity to human RAB1, which is a ras-related GTP-binding protein involved in vesicle transport GTP-binding protein K02E10.2 hid-1;K02E10.2 Protein of unknown function, has weak similarity to uncharacterized S. pombe Spac17a5.16p K02E10.4 K02E10.4 Protein of unknown function, has weak similarity to C. elegans W01F3.3 K02E10.5 K02E10.5 Protein of unknown function K02E10.6 K02E10.6 Protein of unknown function that may be anchored to the membrane of a secretory vesicle or the Golgi apparatus K02E10.7 K02E10.7 Protein with weak similarity to C. elegans par-1 (Serine/threonine protein kinase required for cytoplasmic partitioning during cleavage of early embryonic cells) protein kinase K02E10.8 K02E10.8 Protein containing eight immunoglobulin (Ig) domains, has a region of weak similarity to a region of nephrosis 1 (nephrin) (human NPHS1), which is a putative adhesion molecule that may have a role in the development of the kidney filtration barrier K02E11.1 K02E11.1 Member of the nucleoside transporter family, which transport nucleosides across the plasma, and possibly nuclear, membrane, has a region of low similarity to solute carrier family 29 member 1 (human SLC29A1), which transports nucleosides K02E11.2 K02E11.2 Member of the C. elegans Sre G protein-coupled chemoreceptor family, which are putative chemosensory receptors, has high similarity to uncharacterized C. elegans F40G12.1 7TM receptor, sre family K02E11.3 K02E11.3 Protein of unknown function, has high similarity to uncharacterized C. elegans K02E11.5 K02E11.4 K02E11.4 Member of an uncharacterized protein family K02E11.5 K02E11.5 Protein of unknown function, has high similarity to uncharacterized C. elegans K02E11.6 K02E11.6 K02E11.6 Protein of unknown function, has strong similarity to C. elegans K02E11.5 K02E11.7 K02E11.7 Member of an uncharacterized protein family K02E2.1 K02E2.1 Protein with moderate similarity to C. elegans C15C8.1 gene product K02E2.2 grd-11;K02E2.2 Protein containing a HINT (Hedgehog/Intein) domain, putative paralog of C. elegans GRD-1 K02E2.3 K02E2.3 Member of the 7-transmembrane chemoreceptor family of G protein-coupled receptors (GPCR), has high similarity to uncharacterized C. elegans ZK228.7 chemoreceptor K02E2.4 K02E2.4 Protein of unknown function ins-35 encodes one of several insulin-related peptides. K02E2.6 K02E2.6 Member of the retroviral aspartyl protease family K02E2.7 K02E2.7 Protein with weak similarity to H. sapiens TRIP11 (thyroid hormone receptor interactor 11) K02E2.8 K02E2.8 Protein with moderate similarity to C. elegans C04G6.2 gene product K02E7.1 K02E7.1 Protein containing one C. elegans C-terminal C6 domain, which contain conserved cysteine residues K02E7.10 K02E7.10 Member of the papain family of cysteine proteases, has moderate similarity to cathepsin J (rat Ctsj), which is a lysosomal cysteine protease that exhibits dipeptidyl-aminopeptidase activity protease K02E7.11 K02E7.11 Protein of unknown function, has high similarity to uncharacterized C. elegans Y51H7BR.3 K02E7.2 K02E7.2 Protein of unknown function, has very strong similarity to uncharacterized C. elegans R09E12.5 K02E7.3 K02E7.3 Protein of unknown function, has very strong similarity to uncharacterized C. elegans R09E12.6 K02E7.4 K02E7.4 Protein containing a K+ channel tetramerization domain, which facilitate assembly of alpha-subunits into functional tetrameric channels K02E7.5 K02E7.5 Protein of unknown function, has strong similarity to C. elegans M01D1.2 K02E7.6 K02E7.6 Member of an uncharacterized protein family K02E7.7 K02E7.7 Protein of unknown function, has strong similarity to C. elegans F45D11_39.B K02E7.9 K02E7.9 Protein containing one BTB (BR-C, ttk and babor) or POZ (Pox virus and zinc finger) domain, which are found in some DNA and actin binding proteins and may mediate protein-protein interactions, has strong similarity to uncharacterized C. elegans M01D1.3 K02F2.1 K02F2.1 Member of the prolyl oligopeptidase family, has weak similarity to dipeptidyl aminopeptidase B (DPAP B, S. cerevisiae Dap2p) peptidase K02F2.2 dpy-14;CEAHH;K02F2.2 Protein with high similarity to S-adenosylhomocysteine hydrolase (mouse Ahcy), which reversably converts S-adenosylhomocysteine to adenosine and homocysteine, member of the S-adenosylhomocysteine hydrolase family S-adenosylhomocysteine hydrolase K02F2.3 K02F2.3 Protein with high similarity to splicing factor 3b subunit 3 (human SF3B3), which is a component of the U2 snRNP-associated protein complex SF3b that plays a role in spliceosome assembly K02F2.4 K02F2.4 Protein containing a ubiquitin-like protein-specific protease (Ulp1) family C-terminal catalytic domain, which may bind other protein domains K02F2.5 K02F2.5 Protein of unknown function K02F2.6 K02F2.6 Member of the rhodopsin family of G protein-coupled receptors (GPCR), has low similarity to adrenergic receptor alpha 2b (mouse Adra2b), which signals through adenylyl cyclase and controls blood pressure, sensory perception, synaptic transmission and pain seven trans-membrane receptor; ser-3 encodes a predicted G protein-coupled receptor that is a candidate metabotropic serotonin receptor; SER-3 activity is required for fertility and for embryonic development; to date, SER-3 expression has been detected in the pharynx. K02F3.1 K02F3.1 Member of the conserved C-terminal helicase domain protein family, member of the RECQ family of helicases helicase K02F3.10 K02F3.10 Protein of unknown function K02F3.11 K02F3.11 Protein containing two RNA recognition motifs (RRM, RBD, or RNP), has moderate similarity to RNA-binding protein S1 (human RNPS1), which is a mRNA splicing factor that may play a role in nucleocytoplasmic mRNA export and in nonsense-mediated mRNA decay Probable RNA binding protein; rnp-5 encodes a putative member of the exon-exon junction complex, orthologous to human RNPS1 (OMIM:606447); RNP-5 is dispensable for embryonic viability. K02F3.12 K02F3.12 Putative ortholog of H. sapiens RECQL (RecQ protein-like (DNA helicase Q1-like)) K02F3.2 K02F3.2 Member of the mitochondrial carrier (MCF) protein family, has similarity to H. sapiens MCF family member Aralar which binds calcium The K02F3.2 gene encodes a homolog of human SLC25A13, which when mutated leads to adult onset type II citrullinaemia (OMIM:603471). K02F3.3 K02F3.3 Protein of unknown function, has weak similarity to C. elegans F15B9.1 K02F3.4 K02F3.4 Protein with weak similarity to H. sapiens CEBPG (CCAAT/enhancer binding protein (C/EBP), gamma) K02F3.5 K02F3.5 Protein containing a C-type lectin domain, which mediate calcium-dependent carbohydrate recognition K02F3.6 K02F3.6 Member of the alpha or beta hydrolase fold family, has a region of low similarity to a region of epoxide hydrolase cytoplasmic (mouse Ephx2), which metabolizes xenobiotic molecules and may play a role in blood pressure regulation K02F3.7 K02F3.7 Protein with strong similarity to C. elegans T05D4.4 gene product K02F3.8 K02F3.8 Protein of unknown function K02F3.9 K02F3.9 Protein of unknown function K02F6.1 K02F6.1 Member of the protease protein family K02F6.2 K02F6.2 Putative ortholog of C. elegans K02F6.4 gene product K02F6.3 K02F6.3 Protein containing one ankyrin (Ank) repeat, which may mediate protein-protein interactions, and a WSN domain of unknown function, has high similarity to uncharacterized C. elegans K02F6.4 K02F6.4 K02F6.4 Protein containing two ankyrin (Ank) repeats, which may mediate protein-protein interactions, and a WSN domain of unknown function, has high similarity to uncharacterized C. elegans K02F6.3 K02F6.5 K02F6.5 Protein containing a K+ channel tetramerization domain, which facilitate assembly of alpha-subunits into functional tetrameric channels, has very strong similarity to uncharacterized C. elegans K02F6.8 K02F6.6 K02F6.6 Protein containing a K+ channel tetramerization domain, which facilitate assembly of alpha-subunits into functional tetrameric channels K02F6.7 K02F6.7 Protein of unknown function, has low similarity to uncharacterized C. elegans C04E7.2 K02F6.8 K02F6.8 Protein containing a K+ channel tetramerization domain, which facilitate assembly of alpha-subunits into functional tetrameric channels, has very strong similarity to uncharacterized C. elegans K02F6.5 K02F6.9 K02F6.9 Putative protease, has strong similarity to human endothelin converting enzyme ECE1, a membrane-bound zinc-dependent metalloprotease associated with Hirschsprung disease, heart defects, and autonomic dysfunction K02F6.9 encodes a neprilysin; neprilysins are thermolysin-like zinc metallopeptidases, found on the outer surface of animal cells, that negatively regulate small signalling peptides (e.g., enkephalin, tachykinin, insulin, and natriuretic peptides) by cleaving them; K02F6.9 has no clear orthologs in other organisms. K02G10.1 K02G10.1 Protein containing a DHHC-type zinc finger (NEW1) domain K02G10.3 K02G10.3 Protein of unknown function K02G10.4 flp-11;K02G10.4 Protein with weak similarity to C. elegans flp-6 (KSAYMRF-amide neurotransmitter) K02G10.5 K02G10.5 Protein containing organic anion transporter polypeptide (OATP) family N-terminus and C-terminus domains, has low similarity to solute carrier family 21 member 12 (human SLC21A12), which transports thyroid hormone by a Na+ independent process zinc-finger DNA-binding protein K02G10.6 K02G10.6;lagCe-2 Protein of unknown function, has a region of weak similarity to a region of S. cerevisiae Lac1p, which is required with Lag1p for ceramide synthesis and ER-to-Golgi transport of GPI-anchored proteins hyl-2 encodes a predicted transmembrane protein that is related to Saccharomyces cerevisiae LAG1 (longevity assurance gene), a protein preferentially expressed in young yeasts; by homology, HYL-2 is predicted to have several possible functions, including regulation of lipid, particularly ceramide, biosynthesis, regulation of lipid transport, and regulation of protein translocation in the endoplasmic reticulum ; however, as loss of hyl-2 activity via RNA-mediated interference (RNAi) does not result in any obvious abnormalities, the precise role of hyl-2 in C. elegans development and/or behavior is not yet known. K02G10.7 K02G10.7 Member of the major intrinsic protein (MIP) family, which are transmembrane channels, has low similarity to aquaporin 3 (mouse Aqp3), which is a water transporter that is sensitive to inhibition by mercury and is linked to nephrogenic diabetes insipidus transmembrane channel protein K02G10.8 K02G10.8 Protein with high similarity to cysteine string protein (rat Csp), which is a highly fatty acylated chaperone protein that stimulates rat Hsc70 ATPase activity and is involved in exocytosis regulation, contains a DnaJ domain, which act in protein folding This gene encodes a protein containing a DnaJ ('J') domain. K02H11.2 K02H11.2 Member of the 7-transmembrane chemoreceptor family of G protein-coupled receptors (GPCR), has low similarity to C. elegans ODR-10, which is involved in odorant response 7TM chemoreceptor, str family K02H11.3 K02H11.3 Member of the 7-transmembrane chemoreceptor family of G protein-coupled receptors (GPCR), has weak similarity to C. elegans ODR-10, which is involved in odorant response 7TM chemoreceptor, str family K02H11.4 K02H11.4 Protein containing a DUF23 domain of unknown function, has moderate similarity to uncharacterized C. elegans C13A2.6 K02H11.6 K02H11.6 Member of the thioredoxin family, which are small enzymes involved in redox reactions, has a region of moderate similarity to C. elegans R05H5.3, which may function as a nuclear thioredoxin thioredoxin K02H11.7 K02H11.7 Member of the 7-transmembrane chemoreceptor family of G protein-coupled receptors (GPCR), has low similarity to C. elegans ODR-10, which is involved in odorant response 7TM chemoreceptor, str family K02H8.1 K02H8.1 Protein with strong similarity to D. melanogaster mblC (muscleblind isoform C), a zinc finger protein K03A1.2 K03A1.2 Protein containing 16 leucine rich repeats and two leucine rich repeat C-terminal cysteine rich domains, has a region of low similarity to a region of insulin-like growth factor binding protein acid-labile subunit (human IGFALS) LRR (leucine-rich repeats); FSHR (follicle stimulating hormone receptor) K03A1.4 K03A1.4 Protein containing four EF hand domains, which are found in signaling, buffering or transport proteins, has a region of moderate similarity to calmodulin 1 (mouse Calm1), which regulates the calcium-dependent activity of proteins and enzymes calmodulin calcium-binding sites K03A1.5 sur-5;K03A1.5 Member of the acetyl-CoA synthetase protein family,  negative regulator of let-60 ras function in vulval induction acetyl-coenzyme A synthetase K03A1.6 his-10;his-38;K03A1.6 Histone H4 in the HIS3 gene cluster histone-H4; his-38 encodes an H4 histone; by homology, HIS-38 is predicted to function as a nucleosome component required for packaging of DNA into chromatin; his-38 is a replication-dependent histone locus that does not reside in a cluster, but exists as a single histone locus on the X chromosome. K03A11.1 K03A11.1 Protein of unknown function, has strong similarity to C. elegans T05B4.11 K03A11.2 K03A11.2 Protein with weak similarity to H. sapiens Hs.158294 (Human complexin II mRNA, complete cds) K03A11.3 K03A11.3 Homeodomain transcription factor, has similarity over the homeodomain to many human and D. melanogaster homeodomain transcription factors homeobox protein (NK-2 subfamily); A homeobox protein of the NK-2 family; it is expressed in a single pharyngeal neuron, M4. K03A11.4 K03A11.4 Member of an uncharacterized protein family K03A11.5 K03A11.5 Protein of unknown function K03B4.1 K03B4.1 Protein of unknown function K03B4.2 K03B4.2 Protein of unknown function K03B4.3 taf-11;K03B4.3 Protein of unknown function, has a region of high similarity to a region of TBP-associated factor H (mouse Taf10), which is a component of the TFIID complex involved in the assembly of the transcription complex and regulation of gene expression K03B4.4 K03B4.4 Protein of unknown function K03B4.5 K03B4.5 Protein of unknown function, has moderate similarity to uncharacterized C. elegans C01G10.2 7TM chemoreceptor, srx family K03B4.6 K03B4.6 Protein with strong similarity to C. elegans F14H3.9 gene product K03B4.7 K03B4.7 Protein of unknown function K03B8.1 K03B8.1 Member of the zinc metalloprotease protein family zinc metalloprotease K03B8.2 K03B8.2 Member of the zinc metalloprotease protein family zinc metalloprotease K03B8.3 K03B8.3 Putative zinc metalloprotease, possible paralog of C. elegans K03B8.1 zinc metalloprotease K03B8.4 K03B8.4 Protein of unknown function, has a region of very strong similarity to a region of C. elegans C18E3.2, which is involved in histogenesis and organogenesis K03B8.5 K03B8.5 Member of the zinc metalloprotease protein family zinc metalloprotease K03B8.6 K03B8.6 Protein of unknown function, has a region of low similarity to a region of C. elegans C31B8.8, which is a metalloprotease K03B8.7 K03B8.7 Protein of unknown function containing a Ground-like domain, has weak similarity to C. elegans K10C2.5 K03B8.8 K03B8.8 Protein of unknown function K03B8.9 deg-3;K03B8.9 Subunit of the nicotinic acetylcholine receptor and member of the neurotransmitter-gated ion-channel protein family; mutant forms cause neuronal degeneration in worms nicotinic acetylcholine receptor; deg-3 encodes an alpha subunit of a nicotinic acetylcholine receptor (nAChR); originally defined by a gain-of-function mutation that results in neuronal degeneration and uncoordinated movement, DEG-3 can form heteromeric channels with a second alpha subunit, DES-2, and in vivo these channels appear to be required for chemosensation of choline; deg-3 and des-2 reside in an operon, and consistent with their role in metabolite chemosensation, are expressed in nonsynaptic regions such as the sensory endings of the IL2 chemosensory neurons; DEG-3 and DES-2 are also detected in the touch cell neurons, M1 head muscles, FLP and PVD sensory neurons, and the PVC interneuron; in subsets of these neurons, DEG-3 expression is not detectable in mec-3 or unc-86 mutant backgrounds. K03C7.1 K03C7.1 Protein of unknown function, has a region of low similarity to a region of heavy polypeptide of neurofilament (mouse Nfh), which is a cytoskeletal structural protein that may act in axonal caliber, synaptic transmission, and intermediate filament assembly K03C7.2 K03C7.2 Putative transcription factor of the forkhead family DNA-binding; fkh-9 encodes a member of the forkhead domain transcription factor family. K03C7.3 K03C7.3 Protein of unknown function K03D10.1 kal-1;K03D10.1 Protein with strong similarity to human KAL1 (Kallmann syndrome 1, protein involved in neuronal development), contains a WAP (whey acidic protein) domain and three fibronectin type III domains WAP-type (Whey Acidic Protein) 'four-disulfide core', Fibronectin type III domain (3 domains); kal-1 encodes a cell surface protein that contains a WAP-type protease inhibitor domain and Type III fibronectin domains and is the C. elegans ortholog of human KAL-1, mutated in the X-linked form of the neurological disorder Kallmann syndrome; in C. elegans, both kal-1 loss-of-function mutations and kal-1 overexpression result in similar phenotypes that indicate KAL-1 activity is required for epithelial morphogenesis and axon branching; kal-1 transcriptional reporters reveal expression beginning in the 50-cell stage embryo in 2-3 cells with later embryonic expression in at least 8-10 AB-derived ventral neuroblasts that are a substrate for migrating epidermal cells during ventral enclosure; later expression in larvae and adults is restricted to anterior neurons, including AIY, AIZ, RID, M5, ASI, and labial sensory neurons, ventral nerve cord motorneurons, midbody neurons HSN, CAN, and PVM, tail neurons DVB, DVC, and PDB, and the nonneuronal excretory cell as well as in uterine muscles; in the AIY interneurons, kal-1 is part of a gene battery whose expression is under the control of the CEH-10 and TTX-3 Paired and LIM-type homeodomains, respectively. K03D10.3 K03D10.3 Protein with strong similarity to histone acetyltransferases The K03D10.3 gene encodes a MYST acetyltransferase orthologous to the Drosophila MALES-ABSENT-ON-THE-FIRST (MOF) and CG1894 proteins, the human MOF protein, and the S. cerevisiae SAS2 protein. K03D3.1 K03D3.1 Protein containing a DUF216 domain of unknown function, has high similarity to uncharacterized C. elegans C09G12.2 K03D3.2 K03D3.2 Protein of unknown function, has high similarity to uncharacterized C. elegans F58E2.2 K03D3.3 K03D3.3 Protein containing a DUF216 domain of unknown function, has low similarity to uncharacterized C. elegans F58E2.7 K03D3.4 K03D3.4 Protein containing two DUF216 domains of unknown function K03D3.5 K03D3.5 Protein of unknown function, has strong similarity to uncharacterized C. elegans C09G12.5 K03D3.6 K03D3.6 Protein containing two zinc knuckle domains, which can bind RNA or DNA in eukaryotes Zinc finger, CCHC class (2 domains) K03D3.7 rac-2;CeRac2;K03D3.10;K03D3.9;K03D3.7 Member of the Ras superfamily of GTP-binding proteins, has moderate similarity to cell division cycle 42 (human CDC42), which is a Rho GTPase involved in actin cytoskeleton organization, cell migration, cell cycle progression and apoptosis K03D3.8 K03D3.8 Protein of unknown function, has low similarity to uncharacterized C. elegans Y37H2A.3 Retroviral aspartyl proteases K03D7.11 K03D7.11 Protein of unknown function, has strong similarity to uncharacterized C. elegans K03D7.2 7TM chemoreceptor, srw family K03D7.2 K03D7.2 Protein of unknown function, has strong similarity to uncharacterized C. elegans K03D7.11 7TM chemoreceptor, srw family K03D7.4 K03D7.4 Member of the 7-transmembrane chemoreceptor family of G protein-coupled receptors (GPCR), has strong similarity to uncharacterized C. elegans K10G4.7 K03D7.6 K03D7.6 Member of the 7-transmembrane chemoreceptor family of G protein-coupled receptors (GPCR), has with strong similarity to uncharacterized C. elegans K10G4.6 K03D7.7 K03D7.7 Protein of unknown function, has moderate similarity to C. elegans F09C3.4 This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins; this gene's encoded protein also contains an FTH/DUF38 motif, which may also mediate protein-protein interaction. K03D7.8 K03D7.8 Protein with moderate similarity to C. elegans T23E7.1 gene product K03D7.9 K03D7.9 Protein with strong similarity to C. elegans Y38H6C.21 gene product K03E5.1 K03E5.1 Protein containing two CUB domains, which occur in developmentally regulated proteins, has a region of low similarity to a region of bone morphogenetic protein 1 (human BMP1), which is a metalloprotease that stimulates extracellular matrix formation K03E5.2 K03E5.2 Protein containing four calponin family repeats, has a region of moderate similarity to a region of C. elegans UNC-87, which is an actin-bundling protein calponin K03E5.3 K03E5.3 Protein with high similarity to cell division cycle control protein 2 (rat Cdc2a), which is a cyclin-dependent protein kinase that interacts with B-type cyclins and is involved in entry into mitosis and the G2 checkpoint, contains a protein kinase domain protein kinase K03E5.5 K03E5.5 Protein of unknown function K03E6.1 lim-6;K03E6.1 LIM homeodomain transcription factor involved in asymmetric division of vulval blast cells, has strong similarity to human LIM homeodomain transcription factor LMX1B and D. melanogaster LIM homeodomain transcription factor LIM3 Homeobox protein K03E6.3 Ce-ncs-3;K03E6.3 Protein with high similarity to human FREQ, which is a putative kinase inhibitor that may have a regulatory role in secretion, contains six EF hand domains, which are found in signaling, buffering or transport proteins calcium binding protein; ncs-3 encodes a neuronal calcium sensor (NCS) protein with no obvious null phenotype. K03E6.4 K03E6.4 Protein of unknown function, has weak similarity to C. elegans Y38F2A_5743.H K03E6.5 unc-1;unc-102;K03E6.5 Protein similar to mammalian stomatin required for wild-type sensitivity to anesthetics Erythrocyte band 7 intergral membrane protein; unc-1 encodes a homolog of human stomatin (OMIM:133090; deficient in stomatocytosis); UNC-1 protein is found in major nerve tracts, particularly in the nerve ring; unc-1 is required for anesthetic sensitivity; unc-24, which also encodes a stomatin homolog, is epistatic to unc-1 and is required for UNC-1 localization to the nerve ring. K03E6.6 K03E6.6 Member of the profilin protein family Profilin K03E6.7 K03E6.7 Protein of unknown function, has a region of low similarity to a region of human SH3BP5, which preferentially associates with and inhibits activity of Bruton's tyrosine kinase (BTK) and B cell receptor-induced BTK -dependent calcium mobilization K03F8.1 K03F8.1 Protein of unknown function, has high similarity to uncharacterized C. elegans F59E11.4 K03F8.2 acr-5;K03F8.2 Encodes an alpha-like subunit of a nicotinic acetylcholine receptor ACHR; acr-5 encodes a predicted member of the alpha subunit family of nicotinic acetylcholine receptors that is expressed in the nervous system. K03H1.1 K03H1.1 Protein with high similarity to glutamine synthase (rat Glul), which catalyzes the condensation of glutamate and ammonia to form glutamine and may clear L-glutamate from neuronal synapses, contains one glutamine synthetase domain Glutamine synthetase K03H1.10 K03H1.10 Putative paralog of C. elegans CBP-1, a member of the bromodomain protein family K03H1.11 K03H1.11 Protein of unknown function K03H1.12 K03H1.12 Protein of unknown function K03H1.2 mog-1;K03H1.2 Protein required for the hermaphrodite switch from spermatogenesis to oogenesis RNA helicase (DEAH subfamily); The mog-1 gene encodes a DEAH helicase orthologous to the Drosophila CG1375/1405, the human PRP16, and the S. cerevisiae PRP16 proteins. K03H1.3 K03H1.3 Member of the transthyretin-like family, has very strong similarity to uncharacterized C. elegans F40F12.1 Transthyretin-like family K03H1.4 K03H1.4 Member of the transthyretin-like family, has high similarity to uncharacterized C. elegans K03H1.3 Transthyretin-like family K03H1.5 K03H1.5 Protein containing two von Willebrand factor (vWF) type D domains and a sushi or short consensus repeat (SCR) domain, which are found in complement and adhesion proteins, has a region of moderate similarity to a region of alpha-tectorin (mouse Tecta) Transmembrane and sushi domain K03H1.6 K03H1.6 Member of the transthyretin-like family, has high similarity to uncharacterized C. elegans K03H1.4 Transthyretin-like family K03H1.7 K03H1.7 Protein of unknown function K03H1.8 K03H1.8 Member of the protein-tyrosine phosphatase family, which are involved in control of cell growth, proliferation, differentiation and transformation, has high similarity to uncharacterized C. elegans Y116A8C.37 Protein tyrosine phosphatase K03H1.9 K03H1.9 Protein of unknown function K03H4.1 K03H4.1 Protein of unknown function K03H4.2 K03H4.2 Protein of unknown function K03H6.1 srq-3;K03H6.1 Member of the rhodopsin family of G protein-coupled receptors (GPCR), has moderate similarity to uncharacterized C. elegans SRQ-4 K03H6.2 K03H6.2 Member of the lipase class 3 family, which are a subset of lipolytic enzymes that hydrolyze ester linkages of triglycerides, has high similarity to uncharacterized C. elegans Y49E10.P K03H6.3 K03H6.3 Protein containing a paired box (PAX) domain, has low similarity to TcA transposase (C. elegans C03E10.2), which is an endonuclease and transferase that transfers phosphorus-containing groups K03H6.4 K03H6.4 Protein containing a C-type lectin domain, which mediate calcium-dependent carbohydrate recognition K03H6.5 srq-4;K03H6.5 Member of the rhodopsin family of G protein-coupled receptors (GPCR), has moderate similarity to uncharacterized C. elegans SRQ-3 K03H9.1 K03H9.1 Protein with strong similarity to C. elegans F58F12.3 gene product K03H9.2 K03H9.2 Protein containing two collagen triple helix repeats, has moderate similarity to C. elegans DPY-7, which is a cuticle collagen involved in epithelium morphogenesis and cuticle synthesis collagen alpha chain K03H9.3 K03H9.3 Protein of unknown function, has low similarity to uncharacterizred C. elegans F58F12.3 K04A8.1 K04A8.1 Protein of unknown function, has high similarity to uncharacterized C. elegans K06H6.1 K04A8.10 K04A8.10 Protein containing a UDP-glucoronosyl and UDP-glucosyl transferase domain, has a region of low similarity to a region of olfactory UDP-glucuronosyltransferase (human UGT2A1), which glucuronidates compounds such as odorants, steroids, drugs and carcinogens UDP-glucuronosyltransferase K04A8.2 K04A8.2 Protein of unknown function, has high similarity to uncharacterized C. elegans K04A8.1 K04A8.3 K04A8.3 Protein of unknown function K04A8.4 twk-24;K04A8.4 Member of the 4 TM potassium channel protein family K04A8.5 K04A8.5 Member of the alpha or beta hydrolase fold family, has moderate similarity to lysosomal acid lipase A (human LIPA), which deacylates cholesteryl and triacylglyceryl ester lipids and is associated with Wolman disease and cholesteryl ester storage disease lipase K04A8.6 K04A8.6 Putative paralog of C. elegans F46E10.A gene product This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins. K04A8.7 K04A8.7 Member of the reverse transcriptase protein family, which are RNA-dependent DNA polymerases, has high similarity to uncharacterized C. elegans Y37E3.18 transposon reverse transcriptase K04A8.8 K04A8.8 Protein of unknown function K04A8.9 K04A8.9 Protein of unknown function K04B12.1 K04B12.1 Protein containing three IPT or TIG domains, which contain immunoglobulin-like folds, and three plexin repeats, has low similarity to plexin 1 (mouse Plxn1), which acts as a coreceptor with neuropilin (Nrp) for semaphorins that function in cell repulsion K04B12.2 K04B12.2 Protein of unknown function K04B12.3 K04B12.3 Protein of unknown function K04C1.1 K04C1.1 Protein of unknown function, has high similarity to uncharacterized C. elegans K04C1.6 K04C1.2 K04C1.2 Protein with weak similarity to H. sapiens Hs.198760 (Homo sapiens mRNA for KIAA0845 protein, partial cds) K04C1.3 K04C1.3 Protein of unknown function, has moderate similarity to C. elegans F21G4.5 Zinc finger, C2H2 type K04C1.4 K04C1.4 Protein containing two EF hand domains, which are found in signaling, buffering or transport proteins, has moderate similarity to myosin light chain 1 slow a (human MLC1SA), which may regulate muscle contraction motor activity by modulating actin binding myosin light chain K04C1.5 K04C1.5 Protein containing a protein kinase domain, has high similarity to uncharacterized C. elegans E02H4.6 serine/threonine kinase K04C1.6 K04C1.6 Protein of unknown function, has high similarity to uncharacterized C. elegans K04C1.1 K04C2.2 K04C2.2 Protein of unknown function K04C2.3 K04C2.3 Protein of unknown function K04C2.4 K04C2.4 Protein containing two BRCA1 (breast cancer type 1) C terminus (BRCT) domains and two ankyrin (Ank) repeats, has low similarity to a region of BRCA1 associated RING domain 1 (human BARD1), which may function in BRCA1-mediated tumor suppression K04C2.5 K04C2.5 Protein of unknown function K04C2.6 med-2;K04C2.6 GATA-type transcription factor The med-2 gene encodes a GATA-type transcription factor that is an immediate target of maternal SKN-1, and that participates in specifying the mesendoderm. K04D7.1 K04D7.1 Protein with high similarity to guanine nucleotide binding protein beta 2 related sequence 1 (human GNB2L1), which is a protein kinase C (PKC) anchoring system subunit that is associated with Alzheimers disease, contains seven WD domains (WD-40 repeat) guanine nucleotide-binding protein K04D7.2 K04D7.2 Member of the proteasome complex protein family, contains a putative conserved ATPase domain, has strong similarity to S. cerevisiae intra-mitochondrial sorting protein Msp1p TAT binding homolog 4 like K04D7.3 K04D7.3 Protein with high similarity to 4-aminobutyrate aminotransferase (rat Abat), which catalyzes the formation of glutamate from GABA and alpha-ketoglutarate, member of the aminotransferase class III pyridoxalphosphate-dependent enzyme family 4-aminobutyrate aminotransferase; The gta-1 gene encodes an ortholog of the human gene GABAT, which when mutated leads to GABA-transaminase deficiency (OMIM:137150). K04D7.4 K04D7.4;nemPTP Member of the protein-tyrosine phosphatase family, which are involved in cell differentiation, contains three fibronectin type III domains and an immunoglobulin domain, has low similarity to protein tyrosine phosphatase receptor type D (mouse Ptprd) protein-tyrosine phosphatase K04D7.5 gon-4;K04D7.5 Protein required for the formation of somatic gonadal structures gon-4 encodes a large (1336-residue), unfamiliar, acidic (20% acidic residues and pI of 4.4), nuclear protein directly required for gonadogenesis in both sexes and, indirectly, for proper germ line and vulval development; gon-4 is expressed (and functionally required) in somatic gonadal cells during early gonadal development; while Z1 and Z4 (the somatic gonad precursor cells) appear to be specified correctly in gon-4 mutant L1 larvae, and other postembryonic events in somatic gonadal development appear to still occur at normal times, the postembryonic cell divisions of Z1 and Z4 are greatly delayed or missing in gon-4 larvae; GON-4 is subtly similar to human HCCA2 (OMIM:607860, expression associated with hepatocellular carcinoma). K04E7.1 K04E7.1 Protein of unknown function K04E7.2 pep-2;CPTB;K04E7.2;opt2 Member of the proton-coupled oligopeptide transporter superfamily Oligopeptide transporter K04E7.3 K04E7.3 Member of the astacin family of metalloproteases, contains a CUB domain, which often occurs extracellularly in developmentally regulated proteins, has low similarity to C. elegans HCH-1, which is a putative zinc-dependent metalloprotease zinc metallprotease K04F1.1 K04F1.1 Protein containing a plant ATP-guanido phosphotransferase N-terminal domain K04F1.10 K04F1.10 Protein containing a DUF41 domain of unknown function, has high similarity to uncharacterized C. elegans K04F1.7 K04F1.11 K04F1.11 Protein containing a DUF41 domain of unknown function, has low similarity to uncharacterized C. elegans C17E7.10 K04F1.12 K04F1.12 Protein containing a DUF41 domain of unknown function, has moderate similarity to uncharacterized C. elegans K04F1.10 K04F1.13 K04F1.13 Protein containing a DUF41 domain of unknown function, has moderate similarity to uncharacterized C. elegans K04F1.14 K04F1.14 K04F1.14 Protein containing a DUF41 domain of unknown function, has moderate similarity to uncharacterized C. elegans K04F1.13 K04F1.15 K04F1.15 Member of the aldehyde dehydrogenase protein family aldehyde dehydrogenase K04F1.16 K04F1.16 Protein of unknown function, has strong similarity to C. elegans K09D9.8 7TM chemoreceptor, srh family K04F1.2 K04F1.2 Protein of unknown function, has moderate similarity to uncharacterized C. elegans ZC204.15 7TM chemoreceptor, srw family K04F1.3 K04F1.3 Protein of unknown function, has high similarity to uncharacterized C. elegans ZC204.15 7TM chemoreceptor, srw family K04F1.4 K04F1.4 Protein of unknown function, has high similarity to uncharacterized C. elegans F32A7.2 7TM chemoreceptor, srw family K04F1.5 K04F1.5 Protein of unknown function, has high similarity to uncharacterized C. elegans K09D9.6 7TM chemoreceptor, srh family K04F1.6 K04F1.6 Protein containing a DUF41 domain of unknown function, has moderate similarity to uncharacterized C. elegans K04F1.7 K04F1.7 K04F1.7 Protein containing a DUF41 domain of unknown function, has high similarity to uncharacterized C. elegans K04F1.10 K04F1.8 K04F1.8 Protein of unknown function, has moderate similarity to uncharacterized C. elegans K04F1.9 K04F1.9 K04F1.9 Protein of unknown function, has moderate similarity to uncharacterized C. elegans K04F1.8 K04F10.1 K04F10.1 Protein of unknown function, has a region of moderate similarity to a region of spinocerebellar ataxia type 1 homolog (ataxin-1, mouse Sca1), which is an RNA-binding protein that may function in RNA metabolism and cerebellar development The K04F10.1 gene encodes a homolog of SCA1, which when mutated leads to spinocerebellar ataxia 1 (OMIM:164400). K04F10.2 K04F10.2 Protein of unknown function K04F10.3 K04F10.3 Protein of unknown function K04F10.4 K04F10.4 Putative ortholog of C. elegans K04F10.4B gene product endoprotease; bli-4 encodes a variety of related subtilases (serine endoproteases of the KEX2/subtilisin class), with shared N-termini but varying C-termini, that are collectively required both for larval viability and for stable adhesion of the adult cuticle. K04F10.5 K04F10.5 Member of the reverse transcriptase protein family, which are RNA-dependent DNA polymerases, and member of the apurinic or apyrimidinic (AP) endonuclease family 1, which cleave DNA at AP sites K04F10.6 K04F10.6 Protein with strong similarity to C. elegans F31C3.2 gene product rde-3 was identified in screens for loci required for RNA-mediated interference (RNAi); RDE-3 activity, in addition to being required for RNAi, is also required for low levels of transposon mobilization and meiotic chromosome segregation; the molecular identity of rde-3 is not yet known. | rde-3 encodes a nucleotidyltransferase that is a member of the polymerase beta nucleotidyltransferase superfamily that includes poly(A) polymerases, 2-5 oligoadenylate synthetases, C. elegans GLD-2, and S. cerevisiae Trf4p; by homology, RDE-3 is predicted to function as a poly(A) polymerase whose activity is required for meiotic chromosome segregation, negative regulation of DNA transposition, non-transgene-induced RNAi (i.e. RNAi via feeding is affected, whereas RNAi via expression of sense and antisense RNA from a transgene is not), fertility, and viability; analysis of siRNA levels in rde-3 mutant animals indicates that during RNAi, RDE-3 activity is required at a point upstream of siRNA accumulation; neither the precise mechanistic role of RDE-3 in posttranscriptional silencing, nor the RDE-3 expression pattern, is yet known. K04F10.7 K04F10.7 Protein of unknown function, has moderate similarity to H. sapiens Hs.105911 gene product K04G11.1 K04G11.1 Protein of unknown function K04G11.2 K04G11.2 Protein of unknown function sel-7 encodes a novel protein with two predicted PEST sequences that is conserved in the related nematode C. briggsae and several parasitic nematodes, but has no known homologs in other organisms; sel-7 was identified in screens for suppressors of dominant lin-12 mutations that result in vulvaless and egg-laying defective animals; although loss of SEL-7 function via mutation or RNAi results in no obvious defects in a wild-type background, genetic studies suggests that SEL-7 acts downstream of LIN-12/Notch to positively regulate LIN-12 signaling, perhaps by regulating the activity or formation of the LAG-1, LIN-12(intra), SEL-8 nuclear complex; in vitro, SEL-7 self-associates and also interacts with TIR-1 (F13B10.1B), a protein that contains sterile alpha and Toll interleukin receptor motifs, and MDT-29 (K08E3.8), a glutamine-rich protein similar to mediator complex subunits, however the functional significance of these interactions is not yet known; a SEL-7::GFP translational fusion reveals expression in the nuclei of several cell types, including vulval precursor cells and those of the developing gonad. K04G11.3 K04G11.3 Protein with strong similarity to C. elegans F52G2.3 gene product K04G11.4 K04G11.4 Protein containing seven WD domains (WD-40 repeat), which may mediate protein-protein interactions, has low similarity to platelet-activating factor acetylhydrolase (isoform 1b) alpha subunit (human PAFAH1B1), which is a noncatalytic enzyme subunit guanine nucleotide bionding protein beta subunit K04G11.5 irk-3;K04G11.5 Member of the inward rectifier potassium channel family, which are involved in shaping neuronal excitability, has low similarity to K+ inwardly-rectifying channel subfamily J member 14 (Kir2.4, rat Rn.14528), which has low affinities for Ba2+ and Cs+ inward rectifier potassium channel (IRK) K04G11.6 K04G11.6 Protein of unknown function K04G2.1 K04G2.1 Protein with high similarity to human EIF2S2, which is the beta subunit of the eukaryotic translation initiation factor 2 (eIF2) that binds GDP, contains a translation initiation factor IF2B or IF5 domain translational initiation factor 2 beta subunit K04G2.10 K04G2.10 Protein with weak similarity to C. elegans Y11D7A.14 (Putative myosin, has strong similarity to S. cerevisiae, D. melanogaster and human myosin heavy chain) K04G2.11 K04G2.11 Protein of unknown function K04G2.2 K04G2.2 Protein with strong similarity to C. elegans F01D5.8 gene product BEM-1/BUD5 suppressor-like K04G2.3 K04G2.3 Member of the proteasome complex protein family AAA ATPase; This gene encodes a protein predicted by Eisenberg and coworkers, with 52% accuracy, to be mitochondrial. K04G2.4 K04G2.4 Protein of unknown function K04G2.5 K04G2.5 Protein with high similarity to lysophospholipase 1 (human LYPLA1), which is a putative serine hydrolase that hydrolyzes lysophospholipids, member of the phospholipase and carboxylesterase family, which have broad substrate specificity esterase; This gene encodes a protein predicted by Eisenberg and coworkers, with 52% accuracy, to be mitochondrial. K04G2.6 K04G2.6 Putative ortholog of S. cerevisiae Ylr386p, a protein of unknown function K04G2.7 K04G2.7 Protein of unknown function K04G2.8 K04G2.8 Putative ortholog of C. elegans apr-1 gene product The apr-1 gene encodes an ortholog of human APC (OMIM:175100, mutated in familial adenomatous polyposis) that is required for germline fertility, the control of homeodomain expression (CEH-13 and LIN-39) during embryogenesis and vulval development, and for the migration and elongation of hypodermal cells during embryo morphogenesis; APR-1 is thought to reside in adherens junctions, while also stimulating two beta-catenins in Wnt signalling (HMP-2 in migrating epithelial cells, and BAR-1 in the vulval precursor cells); however, APR-1 also binds PRY-1/axin, and with PRY-1 inhibits RAS-independent Wnt induction of LIN-39. K04G2.9 K04G2.9 Protein with weak similarity to H. sapiens PLP2 (proteolipid protein 2 (colonic epithelium-enriched)) K04G7.1 K04G7.1 Protein of unknown function K04G7.10 K04G7.10 Protein containing an RNA recognition motif (RRM, RBD, or RNP), has low similarity to U1 snRNA-associated protein (S. cerevisiae SNP1), which is a pre-mRNA splicing factor SN-RNP U1 K04G7.11 K04G7.11 Protein of unknown function, has high similarity to uncharacterized human P29 K04G7.2 K04G7.2 Protein of unknown function, has weak similarity to a region of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA)-type glutamate receptor (GluR, C. elegans GLR-1), which is a putative ligand-gated ion channel in post-synaptic structures K04G7.3 K04G7.3 Putative O-linked GlucNAc transferase ogt-1 encodes an ortholog of O-linked N-acetylglucosamine (O-GlcNAc) transferase (OGT; OMIM:300255) with 12 N-terminal tetratricopeptide (TPR) domains (generally thought to enable protein-protein interactions) and a C-terminal putative catalytic domain; OGT catalyses the O-glycosylation of serine or threonine residues with N-acetylglucosamine, notably in nuclear proteins such as nuclear pore proteins, the carboxy-terminal domain (CTD) of the largest subunit of RNA polymerase II (RNAPII), and various transcription factors (e.g., Sp1, c-Fos, c-Jun, c-Myc, v-Erb A, and the estrogen receptor); this glycosylation is not elongated to more complex structures, is dynamic in vivo, and competes for serine or threonine residues similar to those phosphorylated by S/T-kinases, and may thus negatively regulate S/T-kinase signalling; in transgenic animals, OGT-1 accumulates in the nucleus and in perinuclear aggregates; OGT-1 might be recruited to gene promoters by binding to the mSin3A ortholog PQN-28. K04G7.4 K04G7.4 Putative NADH dehydrogenase, has similarity to human NDUFA10 (alpha-1 NADH (ubiquinone) dehydrogenase) NADH dehydrogenase K04H4.1 clb-2;emb-9;zyg-6;K04H4.1 Type IV collagen of basement membrane, ortholog of mammalian alpha1 collagen Collagen; emb-9 encodes the alpha-1 chain of Type IV basement membrane collagen most closely equivalent to human COL4A1 (OMIM:120130) on the basis of biological function; EMB-9 forms heterotrimeric Type IV collagen with LET-2, the alpha-2-like chain, and is required for the assembly and/or secretion of LET-2; EMB-9 is essential for embryonic morphogenesis, particularly epidermal elongation, and for larval development; EMB-9 is expresed primarily by body wall muscles and some somatic cells of the gonad and is detected in nearly all basement membranes. K04H4.2 K04H4.2 Protein of unknown function, has weak similarity to a region of notch homolog 4 (human NOTCH4), which is a transmembrane receptor involved in cell proliferation and developmental processes and associated with various cancers and CADASIL when mutated Chitin-binding motifs K04H4.5 K04H4.5 Protein of unknown function K04H4.6 YMV6;K04H4.6 Protein with similarity to human DNASE2 protein, a lysosomal deoxyribonuclease II K04H8.1 K04H8.1 Protein containing a C-type lectin domain, which mediate calcium-dependent carbohydrate recognition, has moderate similarity to uncharacterized C. elegans C49A1.6 Lectin C-type domain K04H8.2 K04H8.2 Protein with strong similarity to C. elegans C49A1.6 gene product K04H8.3 K04H8.3 Protein of unknown function, predicted to contain a glycosylphosphatidylinositol (GPI) lipid anchor K05B2.2 K05B2.2 Protein with moderate similarity to C. elegans K05B2.1 gene product K05B2.3 ifa-4;Cel-IF-A4;K05B2.3 Member of the intermediate filament family, which are components of the cytoskeleton and nuclear envelope, contains an intermediate filament tail domain, has low similarity to lamin B1 (human LMNB1) Intermediate filament protein; IFA-4 encodes a nonessential intermediate filament protein that is coexpressed with the essential IF protein IFB-1; IFA-4 binds IFB-1 in blot overlay assays; ifa-4 is expressed in larvae in the pharyngeal-intestinal valve, the rectum, some neurons of the tail, the excretory cell, and the intestine of dauer (but not nondauer) larvae; IFA-4 has no function in RNAi assays. K05B2.4 K05B2.4 Putative acyl-CoA thioesterase K05B2.5 K05B2.5 Putative monocarboxylic acid transporter, possible ortholog of D. melanogaster MCT1 (monocarboxylate transporter 1), member of the major facilitator superfamily pes-22 encodes a predicted transmembrane protein that is a member of the monocarboxylate porter subfamily of the major facilitator superfamily of transmembrane transporters; pes-22 was identified in promoter-trapping screens and by homology, is predicted to function in the transport of lactate and pyruvate across cell membranes, possibly as part of a metabolic pathway that allows these metabolites to be converted back to glucose when the organism is under high energy demand; however, as loss of pes-22 activity via RNA-mediated interference (RNAi) does not result in any obvious abnormalities, the precise role of PES-22 in C. elegans development and/or behavior is not yet known; a pes-22 reporter is expressed in the excretory gland cells and the ventral nerve cord from late embryogenesis through adulthood, and also in the intestine in late embryos and early larvae. K05C4.1 pbs-5;K05C4.1 Putative beta-type subunit of 20S proteasome particle Proteasome A-type and B-type K05C4.10 K05C4.10 Protein of unknown function K05C4.11 K05C4.11 Protein containing two CUB domains and a low-density lipoprotein (LDL) receptor class A domain, has a region of low similarity to a region of cubilin (intrinsic factor-cobalamin receptor, rat Cubn), which is a vitamin B12 and intrinsic factor receptor CUB domain (2 domains), Low-density lipoprotein receptor domain class A K05C4.2 K05C4.2 Protein of unknown function K05C4.3 K05C4.3 Protein of unknown function, has low similarity to uncharacterized C. elegans K05C4.9 K05C4.4 K05C4.4 Protein of unknown function, has strong similarity to C. elegans F31C3.2 K05C4.5 K05C4.5 Protein containing four WD domains (WD-40 repeat), which may mediate protein-protein interactions K05C4.6 hmp-2;K05C4.6 Beta-catenin required for body elongation and normal leading-cell migration and adhesion during embryonic ventral closure Armadillo/beta-catenin-like repeats (4 domains); hmp-2 is orthologous to the human gene BETA-CATENIN (CTNNB1; OMIM:116806), which when mutated leads to disease. K05C4.7 K05C4.7 Protein of unknown function K05C4.8 K05C4.8 Protein with moderate similarity to C. elegans Y105E8A.13 gene product K05C4.9 K05C4.9 Protein containing a leucine rich repeat, which mediate protein-protein interactions, has weak similarity to C. elegans ZYG-11, which is required for zygote formation Leucine Rich Repeat (2 copies) (3 domains) K05D4.2 K05D4.2 Member of the 7-transmembrane chemoreceptor family of G protein-coupled receptors (GPCR), has low similarity to C. elegans ODR-10, which is involved in odorant response 7TM receptor K05D4.3 K05D4.3 Protein containing a DUF216 domain of unknown function K05D4.4 K05D4.4 Member of the cytochrome P450 family, has low similarity to cytochrome P450 subfamily 2J polypeptide 2 (human CYP2J2), which is an arachidonic acid epoxygenase cytochrome P450 K05D4.6 K05D4.6 Member of the 7-transmembrane chemoreceptor family of G protein-coupled receptors (GPCR), has high similarity to uncharacterized C. elegans T09F5.8 K05D4.7 K05D4.7 Member of the 7-transmembrane chemoreceptor family of G protein-coupled receptors (GPCR), has moderate similarity to uncharacterized C. elegans Y59A8A.7 K05F1.1 K05F1.1 Protein containing a DX module domain K05F1.10 K05F1.10 Protein containing a trypsin inhibitor-like cysteine rich domain K05F1.2 msp-142;K05F1.2 Sperm-specific protein involved in sperm motility, member of the major sperm protein (MSP) family Major sperm protein (msp-142); msp-142 encodes a protein that belongs to a family of proteins called the Major Sperm Proteins (MSPs) that is conserved in nematodes; this family consists of closely related, small, basic proteins that make up 15% of sperm protein; this multigene family consists of over fifty genes, including many pseudogenes; MSPs are involved in both extracellular signaling and cytoskeletal functions during reproduction-MSP antagonizes Eph/ephrin signaling, in part, by binding VAB-1 Eph receptor tyrosine kinase on oocytes and sheath cells to promote oocyte maturation and MAPK activation; MSPs assemble into fibrous networks that drive movement of the C. elegans sperm; msp genes are expressed only in late primary spermatocytes. K05F1.3 K05F1.3 Member of the acyl-CoA dehydrogenase protein family Acyl-coA dehydrogenase K05F1.4 K05F1.4 Putative ortholog of C. elegans K05F1.5 gene product K05F1.5 K05F1.5 Putative ortholog of C. elegans K05F1.4 gene product K05F1.6 K05F1.6 Member of the sugar (and other) transporter family, has low similarity to C. elegans OCT-1, which is an organic cation membrane transporter with broad substrate specificity K05F1.7 msp-63;msp-63ps;K05F1.7 Member of the major sperm-specific protein (MSP) family Major sperm protein; msp-63 encodes a protein that belongs to a family of proteins called the Major Sperm Proteins (MSPs) that is conserved in nematodes; this family consists of closely related, small, basic proteins that make up 15% of sperm protein; this multigene family consists of over fifty genes, including many pseudogenes; MSPs are involved in both extracellular signaling and cytoskeletal functions during reproduction-MSP antagonizes Eph/ephrin signaling, in part, by binding VAB-1 Eph receptor tyrosine kinase on oocytes and sheath cells to promote oocyte maturation and MAPK activation; MSPs assemble into fibrous networks that drive movement of the C. elegans sperm; msp genes are expressed only in late primary spermatocytes. K05F1.8 K05F1.8 Protein of unknown function K05F1.9 K05F1.9 Protein containing a major sperm protein (MSP) domain, which are involved in sperm motility, has high similarity to uncharacterized C. elegans ZK354.7 K05F6.1 K05F6.1 Protein of unknown function, has moderate similarity to uncharacterized C. elegans K05F6.4 K05F6.10 K05F6.10 Protein with moderate similarity to C. elegans T07H3.3 gene product K05F6.2 K05F6.2 Protein containing an F-box domain, which serve as a link between a target protein and a ubiquitin-conjugating enzyme, has low similarity to uncharacterized C. elegans K05F6.1 This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins; its encoded protein also contains a Pfam-B45 motif of presently unknown function. K05F6.3 K05F6.3 Protein of unknown function, has low similarity to uncharacterized C. elegans K05F6.1 K05F6.4 K05F6.4 Protein containing two F-box domains, which serve as a link between a target protein and a ubiquitin-conjugating enzyme, has moderate similarity to uncharacterized C. elegans K05F6.1 This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins; its encoded protein also contains a Pfam-B45 motif of presently unknown function. K05F6.5 K05F6.5 Member of the arylesterase family, which catalyze organophosphorus ester hydrolysis, contains an F-box domain, which serve as a link between a target protein and a ubiquitin-conjugating enzyme, has a region of low similarity to paraoxonase 2 (human PON2) K05F6.5 encodes an unusual paraoxonase-like protein with an N-terminal F-box domain; it is homologous to the human PARAOXONASE 1 gene (PON1, OMIM:168820), which in some allelic forms is associated with susceptibility to coronary artery disease. K05F6.6 K05F6.6 Protein containing a K+ channel tetramerization domain, which facilitate assembly of alpha-subunits into functional tetrameric channels K05F6.7 K05F6.7 Protein containing an F-box domain, which serve as a link between a target protein and a ubiquitin-conjugating enzyme, has moderate similarity to uncharacterized C. elegans F58E1.14 K05F6.8 K05F6.8 Protein containing an F-box domain, which serve as a link between a target protein and a ubiquitin-conjugating enzyme This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins. K05F6.9 K05F6.9 Protein containing an F-box domain, which serve as a link between a target protein and a ubiquitin-conjugating enzyme, has moderate similarity to uncharacterized C. elegans M01D1.10 This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins; its encoded protein also contains a Pfam-B45 motif of presently unknown function. K05G3.1 K05G3.1 Protein containing a 3'-5' exonuclease domain, which catalyze the hydrolysis of mismatched or unpaired nucleotides K05G3.2 K05G3.2 Protein of unknown function K05G3.3 K05G3.3 Protein containing a eukaryotic-type carbonic anhydrase domain, which catalyze reversible hydration of carbon dioxide, has moderate similarity to carbonic anhydrase 2 (rat Ca2), which catalyzes hydration of carbon dioxide to bicarbonate carbonic anhydrase; carbonic anhydrase 2. K06A1.1 K06A1.1 Protein of unknown function, has a region of high similarity to a region of transcription factor AP-2 gamma (mouse Tcfap2c), which is a transcription co-activator of placenta-specific genes and may play a key role in trophoblast development transcription factor AP-2 K06A1.2 K06A1.2 Protein of unknown function K06A1.3 K06A1.3 Protein of unknown function, has strong similarity to C. elegans CUT-1 (cuticulin component) Cuticulin precursor K06A1.4 nhr-22;K06A1.4 Member of the nuclear hormone receptor protein family C4-type zinc finger domain K06A1.5 K06A1.5 Protein containing seven WD domains (WD-40 repeat), which may mediate protein-protein interactions, has weak similarity to S. cerevisiae Ste4p, which is a beta subunit of a trimeric G protein that mediates signal transduction by pheromones K06A1.6 K06A1.6 Protein containing a diacylglycerol kinase (DAGK) accessory domain, which are involved in the conversion of diacylglycerol, and a diacylglycerol kinase catalytic domain (presumed), has moderate similarity to diacylglycerol kinase zeta (rat Dgkz) DIACYLGLYCEROL KINASE K06A4.1 K06A4.1 Member of the astacin (M12A) family of metalloproteases, has a region of low similarity to a region of bone morphogenetic protein 1 (human BMP1), which is a metalloprotease that cleaves C-propeptides of procollagens I, II, and III zinc metalloprotease K06A4.2 K06A4.2 Protein of unknown function K06A4.3 K06A4.3 Member of the gelsolin family, which act as actin-modulating proteins that end-block or cap actin filaments, has low similarity to adseverin (mouse Scin), which caps, severs, and nucleates actin in a calcium-dependent manner gelsolin K06A4.4 K06A4.4 Protein of unknown function K06A4.5 K06A4.5 Protein with high similarity to 3-hydroxyanthranilate 3,4-dioxygenase (human HAAO), which catalyzes the conversion of 3-hydroxyanthranilic acid to quinolinic acid in nicotinic acid biosynthesis and tryptophan catabolism 3-hydroxyanthranilate 3,4-dioxygenase K06A4.6 K06A4.6 Protein with moderate similarity to C. elegans K06A4.1 gene product K06A5.1 K06A5.1 Protein with strong similarity to C. elegans ZK973.2 gene product K06A5.2 K06A5.2 Protein of unknown function, has low similarity to uncharacterized C. elegans W03D8.9 K06A5.3 K06A5.3 Protein containing a major sperm protein (MSP) domain, which are involved in sperm motility K06A5.4 K06A5.4 Protein of unknown function K06A5.6 K06A5.6 Member of the acyl-CoA dehydrogenase protein family acyl-coA dehydgrogenase K06A5.7 K06A5.7;cdc-25.1 Protein involved in cell division, has weak similarity to human and D. melanogaster CDC25 homologs protein phosphatase; cdc-25.1 encodes a CDC25 phosphatase homolog that affects embryonic viability, meiosis, mitosis, proliferation of the intestine (E cell lineage), and germ line proliferation; it is expressed in the developing germline, in the nuclei of oocytes, embryonic nuclei, nuclei of embryonic cortical membranes, and sperm pronuclei, and in the germline precursors Z2 and Z3. K06A5.8 K06A5.8 Protein containing ten WD domains (WD-40 repeat), which may mediate protein-protein interactions, has a region of weak similarity to a region of C. elegans LIN-23, which is an F-box WD-repeat protein that is required for regulating cell proliferation K06A9.1 K06A9.1 Protein with low similarity to S. cerevisiae Fig2p, which is involved in mating induction The K06A9.1 gene encodes an homolog of human TCOF1, which when mutated leads to Treacher-Collins syndrome (OMIM:154500). K06A9.2 K06A9.2 Protein of unknown function This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins. K06A9.3 K06A9.3 Protein containing an epidermal growth factor (EGF)-like domain K06B4.1 nhr-51;K06B4.1 Member of the nuclear hormone receptor/Zinc finger protein family Zinc finger, C4 type (two domains) K06B4.10 K06B4.10 Protein containing two nuclear hormone receptor C4-type zinc finger domains and a nuclear hormone receptor ligand-binding domain, has weak similarity to estrogen-related receptor beta (mouse Esrrb), which is a putative transcription factor Zinc finger, C4 type (two domains) (2 domains) K06B4.11 nhr-53;K06B4.11 Member of the nuclear hormone receptor/Zinc finger protein family Zinc finger, C4 type (two domains) K06B4.12 K06B4.12 Member of the ion transport family, which include calcium, sodium, and potassium channels, has a region of low similarity to a region of potassium channel subfamily K member 1 (TWIK-1, human KCNK1), which forms disulfide-linked homodimeric K+ channels potassium channel protein K06B4.2 nhr-52;K06B4.2 Member of the nuclear hormone receptor/Zinc finger protein family Zinc finger, C4 type (two domains) K06B4.3 K06B4.3 Protein of unknown function, has weak similarity to C. elegans Y41C4A.13 K06B4.4 K06B4.4 Protein of unknown function K06B4.5 K06B4.5 Protein containing nuclear hormone receptor C4-type zinc finger and ligand-binding domains, has moderate similarity to C. elegans NHR-51, which is a putative transcription factor involved in developmental processes Zinc finger, C4 type (two domains) K06B4.6 K06B4.6 Protein containing nuclear hormone receptor C4-type zinc finger and ligand-binding domains, has moderate similarity to C. elegans NHR-51, which is a putative transcription factor involved in developmental processes Ligand-binding domain of nuclear hormone receptors, Zinc finger, C4 type (two domains) K06B4.7 K06B4.7 Protein containing nuclear hormone receptor C4-type zinc finger and ligand-binding domains, has moderate similarity to C. elegans NHR-51, which is a putative transcription factor involved in developmental processes Ligand-binding domain of nuclear hormone receptors, Zinc finger, C4 type (two domains) K06B4.8 K06B4.8 Protein containing nuclear hormone receptor ligand-binding and C4-type zinc finger domains, has moderate similarity to C. elegans NHR-51, which is a putative transcription factor involved in developmental processes Zinc finger, C4 type (two domains) K06B4.9 K06B4.9 Protein of unknown function, has high similarity to uncharacterized C. elegans R13D11.9, which is predicted to be a G protein-coupled receptor 7TM receptor, srx family K06B9.1 K06B9.1 Member of the cytochrome P450 family, has low similarity to a region of cytochrome P450 subfamily 3A polypeptide 4 (human CYP3A4), which is a major drug metabolizing enzyme cytochrome P450 K06B9.2 K06B9.2 Member of the UTP-glucose-1-phosphate uridylyltransferase family, has moderate similarity to a region of UDP-N-acetylglucosamine pyrophosphorylase 1 (sperm associated antigen 2, human UAP1), which acts in UDP-N-acetylglucosamine synthesis K06B9.3 K06B9.3 Protein with moderate similarity to C. elegans C36A4.4 (Member of the UDP-N-acetylglucosamine pyrophosphorylase protein family) K06B9.4 K06B9.4 Protein of unknown function, has high similarity to uncharacterized C. elegans C18H2.2 K06B9.5 K06B9.5 Protein with high similarity to C. elegans EGL-38, which is a homeodomain transcription factor involved in hindgut development and in the regulation of LIN-3, contains a paired box (PAX) domain paired box transcription factor K06C4.1 K06C4.1 Protein of unknown function, has moderate similarity to C. elegans C17B7.2 K06C4.10 his-18;K06C4.10 Protein with very strong similarity to H4 histone family member E (human H4FE), which is a chromatin assembly complex component that may play a role in the condensation of DNA into nucleosomes, member of the histone family of nucleosomal core proteins histone H4; his-18 encodes an H4 histone; by homology, HIS-18 is predicted to function as a nucleosome component required for packaging of DNA into chromatin; his-18 is a replication-dependent histone locus that resides in the HIS4 cluster on chromosome V. K06C4.11 his-19;K06C4.11 Protein with very strong similarity to C. elegans HIS-16, member of the histone family of nucleosomal core proteins histone H2A; his-19 encodes an H2A histone; his-19 is contained within the histone gene cluster HIS4. K06C4.12 his-22;K06C4.12 Protein with high similarity to histone H2B (S. cerevisiae Htb1p), which plays a role in chromatin organization, member of the histone family of nucleosomal core proteins histone H2B; his-22 encodes an H2B histone. K06C4.13 his-27;K06C4.13 Member of the histone H3 protein family histone H3; his-27 encodes an H3 histone; by homology, HIS-27 is predicted to function as a nucleosome component required for packaging of DNA into chromatin; his-27 is a replication-dependent histone locus that resides in the HIS4 cluster on chromosome V. K06C4.14 K06C4.14 Putative paralog of C. elegans Y43F4A.2 K06C4.15 K06C4.15 Protein of unknown function, putative paralog of C. elegans Y43F4A.2 K06C4.17 K06C4.17 Protein with strong similarity to C. elegans F21C10.9 gene product K06C4.2 his-28;K06C4.2 Protein with very strong similarity to H4 histone family member E (human H4FE), which is a chromatin assembly complex component that may play a role in condensation of DNA into nucleosomes, member of the histone family of nucleosomal core proteins histone H4; his-28 encodes an H4 histone. K06C4.3 his-21;K06C4.3 Protein with very strong similarity to C. elegans HIS-16, which is involved in cell migration, regulation of body size, histogenesis and organogenesis and DNA packaging, member of the histone family of nucleosomal core proteins histone H2A; his-21 encodes an H2A histone. K06C4.4 his-20;K06C4.4 Strongly similar to C. elegans HIS-8, member of the histone H2B protein family histone H2B; his-20 encodes an H2B histone; by homology, HIS-20 is predicted to function as a nucleosome component required for packaging of DNA into chromatin. K06C4.5 his-17;K06C4.5 Member of the histone H3 protein family histone H3; his-17 encodes an H3 histone; his-17 is contained within the histone gene cluster HIS4. K06C4.6 mod-1;K06C4.6 Serotonin-gated chloride channel ligand-gated ionic channel protein K06C4.7 K06C4.7 Protein of unknown function K06C4.8 K06C4.8 Putative paralog of C. elegans K06C4.9 G-protein coupled receptor K06C4.9 K06C4.9 Putative paralog of C. elegans K06C4.8 transmemebrane protein K06G5.1 K06G5.1 Protein containing a CUB domain, which often occurs extracellularly in developmentally regulated proteins K06G5.2 K06G5.2 Member of the cytochrome P450 family, has low similarity to cytochrome P450 subfamily 3a polypeptide 9 (rat Cyp3a9), which is a sexually dimorphically expressed enzyme that demethylates erythromycin and benzphetamine Cytochrome P450 K06G5.3 K06G5.3 Protein of unknown function K06H6.1 K06H6.1 Protein of unknown function, has high similarity to uncharacterized C. elegans K04A8.1 K06H6.2 K06H6.2 Member of an uncharacterized protein family K06H6.3 K06H6.3 Protein with low similarity to solute carrier family 35 (UDP-N-acetylglucosamine(UDP-GlcNAc) transporter) member 3 (human SLC35A3), which transports nucleotide sugars K06H6.4 K06H6.4 Protein containing a DUF138 domain of unknown function, has high similarity to uncharacterized C. elegans T15D6.10 K06H6.5 K06H6.5 Protein of unknown function, has high similarity to uncharacterized C. elegans C31B8.9 K06H6.6 K06H6.6 Member of the glycosyl transferase family 11, which hydrolyze the glycosidic bond between two or more carbohydrates, has high similarity to uncharacterized C. elegans C14C6.3 K06H7.1 plk-1;plc1;C14B9.4;K06H7.1 Serine/threonine protein kinase with strong similarity to Drosophila POLO, human PLK, yeast Cdc5p, and other members of the polo family, which are involved in activation of the anaphase-promoting complex in late mitosis Protein kinase K06H7.2 K06H7.2 Protein containing an F-box domain, which serve as a link between a target protein and a ubiquitin-conjugating enzyme, has moderate similarity to uncharacterized C. elegans T05H4.15 This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins. K06H7.3 K06H7.3 Protein of unknown function, has weak similarity to uncharacterized S. cerevisiae Ydr049p Isopentenyl-diphosphate delta isomerase K06H7.4 grp-1;grp1;K06H7.4 Protein containing a Sec7 domain, which are guanine nucleotide exchange factors for ARF GTPases, contains a pleckstrin homology (PH) domain, which mediate protein-protein and protein-lipid interactions, has moderate similarity to cytohesin 3 (mouse Pscd3) sec7; This gene encodes a protein predicted by Eisenberg and coworkers, with 52% accuracy, to be mitochondrial. K06H7.6 apc-2;K06H7.6 Protein of unknown function, has a region of low similarity to a region of anaphase-promoting complex subunit 2 (human APC2), which is a ubiquitin protein ligase that is involved in the ubiquitin-dependent degradation of cyclin cell-cycle proteins K06H7.7 K06H7.7 Protein of unknown function K06H7.8 K06H7.8 Protein with similarity to serine/threonine protein kinase of the casein kinase I subfamily, has similarity to S. cerevisiae Yck1p and Yck2p casein kinase I isoforms K06H7.9 K06H7.9 Protein of unknown function The K06H7.9 gene encodes a NUDIX hydrolase. K07A1.1 K07A1.1 Protein of unknown function K07A1.10 K07A1.10 Protein of unknown function K07A1.11 rba-1;K07A1.11 Member of the WD repeat protein family retinablastoma-binding protein RBAP46 like K07A1.12 rba-2;lin-53;K07A1.12 Class B synthetic multivulva gene which is redundant with the Class A synthetic multivulva pathway in antagonizing vulval induction, may act in chromatin formation chromatin assembly factor 1 P55 subunit like K07A1.13 K07A1.13 Protein of unknown function K07A1.2 K07A1.2 Member of the dUTPase family, which hydrolyze dUTP during uridine metabolism, has a region of high similarity to dUTP pyrophosphatase (rat Dut), which maintains dUTP at low levels to prevent misincorporation into DNA during replication deoxyuridine 5'-triphosphate nucleotidohydrolase; This gene encodes a protein predicted by Eisenberg and coworkers, with 52% accuracy, to be mitochondrial. K07A1.3 K07A1.3 Protein of unknown function K07A1.4 K07A1.4 Protein of unknown function, has similarity in the N-terminal half to C. elegans C18H7.7 and similarity in the C-terminal half to C. elegans R102.4, a putative threonine aldolase K07A1.5 K07A1.5 Protein containing a DUF236 domain of unknown function, has high similarity to uncharacterized C. elegans F42H11.1 K07A1.6 K07A1.6 Protein containing a trypsin inhibitor-like cysteine rich domain K07A1.7 K07A1.7 Protein of unknown function K07A1.8 K07A1.8 Protein with moderate similarity to mannose-binding lectin 1 (human LMAN1), which is involved in traffic of glycoproteins between the endoplasmic reticulum and the Golgi apparatus and is associated with combined factor V and VIII coagulation deficiency P58 protein like; ile-1 is orthologous to the human gene human ERGIC-53, which when mutated leads to deficiency of coagulation factors V/VIII (OMIM:227300). K07A1.9 K07A1.9 Protein with moderate similarity to arginyl-tRNA-protein transferase (R-transferase, mouse Ate1), which conjugates arginine to N-terminal aspartate and glutamate residues of proteins thus promoting their degradation by the N-end rule pathway arginyl-tRNA protein transferase like K07A12.1 K07A12.1 Protein of unknown function, has low similarity to uncharacterized human KIAA1049 K07A12.2 K07A12.2 Protein containing 14 leucine rich repeats, which mediate protein-protein interactions, has a region of low similarity to a region of C. elegans SYM-1, which is required for attachment of body muscle to cuticle in the absence of C. elegans MEC-8 Rat insulin-like growth factor binding protien complex acid labile chain like K07A12.3 K07A12.3 Protein with similarity to human F1F0-type ATP synthase subunit g, putative paralog of C. elegans C53B7.4 ATP synthase subunit g; asg-1 encodes a homolog of the proton-translocating F0 ATP synthase complex subunit g; by homology, ASG-1 is predicted to function in ATP synthesis, although its precise role in ATP anabolism is not yet known; in C. elegans, asg-1 activity is required for transposon silencing in the germline, suggesting that healthy energy metabolism is necessary for this process; in addition, large-scale RNAi screens indicate that asg-1 activity is required for embryonic and germline development, normal post-embryonic growth rates, and normal body morphology. K07A12.4 K07A12.4 Protein containing elongation factor Tu GTP binding, domain 2, and C-terminal domains, has moderate similarity to HSB1-like (eukaryotic release factor 3, human HBS1L), which is a GTP-binding protein involved in translation termination elongation factor 1-alpha K07A12.5 K07A12.5 Protein of unknown function K07A12.6 hot-5;K07A12.6 Ly-6-related protein hot-5 encodes a predicted membrane-associated protein that is a member of the Ly-6 superfamily of glycosylphosphatidylinositol (GPI)-linked signaling proteins and is homologous to ODR-2, a neuronally expressed protein required for olfaction; as loss of hot-5 activity via RNA-mediated interference (RNAi) does not result in any abnormalities, the precise role of HOT-5 in C. elegans development and/or behavior is not yet known. K07A12.7 K07A12.7 Possible small ribosomal subunit protein K07A3.1 K07A3_50.C;K07A3.B;K07A3.1 Putative fructose-1,6-bisphosphatase fructose-bisphosphatase; fbp-1 encodes fructose 1,6-bisphosphatase, a gluconeogenic enzyme that catalyzes the hydrolysis of fructose 1,6-bisphosphate to fructose 6-phosphate and inorganic phosphate in a reaction that reverses the third enzymatic step of glycolysis; in C. elegans, loss of fbp-1 activity via RNA-mediated interference (RNAi) does not result in any obvious abnormalities; FBP-1 is orthologous to human FBP1 (OMIM:229700, mutated in FBP deficiency). K07A3.2 ptr-12;K07A3.2 Putative paralog of C. elegans K07A3_50.B K07A3.3 K07A3.3 Putative paralog of C. elegans K07A3_50.A (Protein with strong similarity to bacterial clpX protein, a chaperone and a regulatory subunit of Clp protease that is induced by heat shock) chaperone K07A9.2 cmk-1;K07A9.2 Serine/threonine protein kinase, has similarity to human, D. melanogaster, and S. cerevisiae calcium/calmodulin-dependent protein kinases ser/thr protein kinase; An ortholgue of mammalian CaM-KI that is involved in calcium dependent signal transduction; it is expressed in some sensory neurons in the head and tail. K07A9.3 K07A9.3 Protein of unknown function K07B1.1 K07B1.1 Member of the trypsin family of serine proteases K07B1.2 K07B1.2 Member of the flavoprotein monooxygenase family of aromatic ring hydroxylases, has low similarity to S. cerevisiae Coq6p, which is a monooxygenase required for coenzyme Q (ubiquinone) biosynthesis coq-6 encodes a putative aromatic-ring monooxygenase, homologous to yeast COQ6; COQ-6 is required for ubiquinone biosynthesis and for normally short lifespan; coq-6(RNAi) animals have reduced levels of coenzyme Q8, coenzyme Q9, and superoxide, and have abnormally long lifespans. K07B1.3 K07B1.3 Protein with high similarity to uncoupling protein 4 (human UCP4), which is an mitochondrial transporter that uncouples electron transport from oxidative phosphorylation, member of the mitochondrial carrier protein family of membrane transporters proton-channel protein K07B1.4 K07B1.4 Protein of unknown function, has high similarity to uncharacterized C. elegans Y53G8B.2 K07B1.5 K07B1.5 Protein of unknown function, has moderate similarity to uncharacterized human KIAA0205 K07B1.6 K07B1.6 Protein of unknown function K07B1.7 K07B1.7 Protein containing two G-patch domains, which are found in RNA processing proteins, has low similarity to uncharacterized human FLJ12455 K07B1.8 K07B1.8 Protein of unknown function K07C10.1 ptr-13;K07C10.1 Member of the patched family, which are transmembrane receptors, has weak similarity to a region of Niemann-Pick disease type C1 (human NPC1), which is a lysosomal protein that plays a role cholesterol transport ptr-13 encodes a member of the Patched superfamily. K07C11.1 K07C11.1 Protein containing a paired box (PAX) domain, has a region of high similarity to a region of paired box gene 9 (mouse Pax9), which is a transcription factor that may play a role in tooth development DNA-binding transcription factor K07C11.10 K07C11.10 Protein of unknown function, has weak similarity to C. elegans Y38H6C.3 K07C11.2 air-1;K07C11.2 Serine/threonine protein kinase associated with mitotic chromosomes, required for cytokinesis and polar body extrusion; has strong similarity to Drosophila AURORA and S. cerevisiae Ipl1p protein kinases, both of which are involved in chromosome segregation protein kinase; AIR-1 belongs to the Aurora-A family of serine/threonine kinases that localize to centrosomes; AIR-1 is required for embryonic survival, germline proliferation and development, locomotion, and vulval development; AIR-1 is required to recruit centrosomal gamma-tubulin during maturation; Aurora-A kinases are implicated in centrosome separation and spindle assembly. K07C11.3 K07C11.3 Protein of unknown function, has weak similarity to C. elegans K07C11.5 K07C11.4 K07C11.4 Member of the carboxylesterase protein family esterase K07C11.5 K07C11.5;5I683 Member of the tissue inhibitor of metalloproteinases family, which irreversibly inactivate extracellular matrix metalloproteinases metalloproteinase inhibitor; K07C11.5 is orthologous to the human gene SIMILAR TO TISSUE INHIBITOR OF METALLOPROTEINASE 3 (SORSBY FUNDUS DYSTROPHY, PSEUDOINFLAMMATORY) (TIMP3; OMIM:188826), which when mutated leads to disease. K07C11.7 K07C11.7 Protein of unknown function, has high similarity to uncharacterized C. elegans C25E10.12 K07C11.8 K07C11.8 Protein of unknown function K07C11.9 K07C11.9 Protein of unknown function, has weak similarity to uncharacterized human KIAA1134 K07C5.1 K07C5.1;ACTL Protein with high similarity to actin-related protein 2 homolog (human ACTR2), which is involved in cell migration and is activated by the Wiskott Aldrich syndrome protein for actin filament nucleation and polymerization, member of the actin family actin K07C5.2 K07C5.2 Member of the aldo-keto reductase family, which include some related monomeric NADPH-dependent oxidoreductases, has low similarity to NAD(P)H-dependent xylose reductase (C. tropicalis XYRB), which is a subunit of xylose reductases II and III reductase K07C5.3 K07C5.3 Protein containing a Poly(ADP-ribose) polymerase zinc finger domain, which bind DNA and are involved in DNA nick detection, has low similarity to a region of ATP-dependent DNA ligase III (human LIG3), which is a DNA ligase is involved in DNA repair DNA ligase like domain K07C5.4 K07C5.4 Protein with high similarity to S. cerevisiae Sik1p, which is a nucleolar protein component of box C-D snoRNPs that are involved in 2'-O-methylation of ribosomal RNAs, contains a putative snoRNA binding domain, which may bind RNA or ribonuclear proteins yeast protein L8167.9-like K07C5.5 K07C5.5 Member of the alpha or beta hydrolase fold family, has weak similarity to a region of epoxide hydrolase cytoplasmic (mouse Ephx2), which metabolizes xenobiotic molecules and may play a role in blood pressure regulation hydrolase K07C5.6 K07C5.6 Protein containing a zinc knuckle domain, which can bind RNA or DNA in eukaryotes, has moderate similarity to splicing factor SLU7 (human SLU7), which plays an essential role in the spliceosome structure transition that occurs prior to step I Zinc finger, CCHC class K07C5.7 K07C5.7 Protein of unknown function K07C5.8 K07C5.8 Protein containing five WD domains (WD-40 repeat), which may mediate protein-protein interactions, has moderate similarity to striatin (mouse Strn), which binds to and possibly regulates the protein phosphatase 2A complex nuclear autoantigen K07C6.1 K07C6.1 Protein containing a DUF216 domain of unknown function, has low similarity to uncharacterized C. elegans Y68A4A.6 K07C6.10 K07C6.10 Member of the rhodopsin family of G protein-coupled receptors (GPCR), has high similarity to uncharacterized C. elegans K07C6.11 7TM chemoreceptor, srx family K07C6.11 K07C6.11 Member of the rhodopsin family of G protein-coupled receptors (GPCR), has high similarity to uncharacterized C. elegans K09D9.10 7TM chemoreceptor, srx family K07C6.12 K07C6.12 Member of the transposase family, which are required for excising and inserting mobile genetic elements, has very strong similarity to uncharacterized C. elegans C14A6.4 K07C6.13 K07C6.13 Protein of unknown function, has high similarity to uncharacterized C. elegans K09D9.10 K07C6.14 K07C6.14 Protein with high similarity to C. elegans C01B12.6, which is a transposase, member of the transposase family, which are required for excising and inserting mobile genetic elements, contains a retroviral integrase core domain K07C6.15 K07C6.15 Protein of unknown function, has high similarity to uncharacterized C. elegans K07C6.9 K07C6.2 K07C6.2 Member of the cytochrome P450 family, has low similarity to cytochrome P450 subfamily 2C polypeptide 8 (mephenytoin 4-hydroxylase, human CYP2C8), which is a heme-binding monooxygenase that metabolizes steroids, fatty acids, and xenobiotics cytochrome P450 K07C6.3 K07C6.3 Member of the cytochrome P450 family, has low similarity to cytochrome P450 subfamily 2C polypeptide 8 (mephenytoin 4-hydroxylase, human CYP2C8), which is a heme-binding monooxygenase that metabolizes steroids, fatty acids, and xenobiotics cytochrome P450 K07C6.4 K07C6.4 Member of the cytochrome P450 family, has low similarity to cytochrome P450 subfamily 2C polypeptide 8 (mephenytoin 4-hydroxylase, human CYP2C8), which is a heme-binding monooxygenase that metabolizes steroids, fatty acids, and xenobiotics cytochrome P450 K07C6.5 K07C6.5 Member of the cytochrome P450 family, has low similarity to cytochrome P450 subfamily 2F polypeptide 1 (mouse Cyp2f2), which is a monooxygenase that catalyzes hydroxylation of naphthalene cytochrome P450 K07C6.6 K07C6.6 Protein of unknown function, has high similarity to uncharacterized C. elegans K07C6.9, which is predicted to be a G protein-coupled receptor 7TM chemoreceptor, srx family K07C6.7 K07C6.7 Putative G protein-coupled receptor, no homolog found in human or D. melanogaster 7TM chemoreceptor, srx family K07C6.8 K07C6.8 Protein of unknown function, has high similarity to C. elegans K07C6.9, which is predicted to be a G protein-coupled receptor 7TM chemoreceptor, srx family K07C6.9 K07C6.9 Protein of unknown function, has high similarity to uncharacterized C. elegans K07C6.8 7TM chemoreceptor, srx family K07D4.2 K07D4.2 Protein of unknown function, has weak similarity to C. elegans F42H11.2 K07D4.3 rpn-11;K07D4.3 Protein with high similarity to 26S proteasome-associated pad1 homolog (human POH1), which is a subunit of the 26S proteasome that confers multidrug resistance and resistance to ultraviolet light, member of the Mov34, MPN or PAD-1 family rpn-11 encodes a predicted non-ATPase subunit of the 19S regulatory complex of the proteasome that affects adult viability, osmoregulation, embryonic viability, and movement; interacts with itself, RPN-9, and F55A11.3, based on yeast two-hybrid assays. K07D4.4 K07D4.4 Protein of unknown function K07D4.5 K07D4.5 Protein of unknown function K07D4.6 K07D4.6 Protein with weak similarity to C. elegans F57H12.3 K07D4.7 K07D4.7 Putative ortholog of C. elegans K07D4.7A gene product K07D4.8 K07D4.8 Protein of unknown function, has weak similarity to C. elegans F37H8.5 The protein product of this gene is predicted to contain a glutamine/asparagine (Q/N)-rich ('prion') domain, by the algorithm of Michelitsch and Weissman (as of the WS77 release of WormBase, i.e., in wormpep77). K07D8.2 mup-4;Yny3;K07D8.1;K07D8.2 Member of the EGF-repeat protein family; required for hypodermal closure and attachment of nerve cords K07E1.1 K07E1.1 Member of the acireductone dioxygenase family, has moderate similarity to uncharacterized human SIPL K07E12.1 dig-1;K07E12.1 Protein involved in gonad development, member of the immunoglobulin superfamily CAM K07E12.2 K07E12.2 Protein of unknown function K07E3.1 K07E3.1 Protein with weak similarity to S. cerevisiae YIL169C K07E3.2 K07E3.2 Protein of unknown function K07E3.3 dao-3;K07E3.3 Member of the C1-tetrahydrofolate synthase protein family methylenetetrahydrofolate dehydrogenase; dao-3 encodes a protein containing a tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain; expression is regulated by DAF-2. K07E3.4 K07E3.4 Member of the formate-tetrahydrofolate ligase family, which participate in transfer of one-carbon units, has high similarity to a region of C1-tetrahydrofolate synthase (rat LOC64300), which is a trifunctional enzyme tetrahydrofolate synthase K07E3.7 K07E3.7 Member of the E1-E2 (P-type) ATPase family, which are cation transporters, member of the haloacid dehalogenase or epoxide hydrolase family, has low similarity to a putative Ca2+-transporting ATPase (S. cerevisiae SPF1) K07E3.8 K07E3.8 Putative ortholog of C. elegans K07E3.6 gene product K07E8.1 K07E8.1 Protein of unknown function, has moderate similarity to C. elegans T02H6.D K07E8.10 K07E8.10 Protein of unknown function, has strong similarity to C. elegans R09E12.5 7TM chemoreceptor, sri family K07E8.11 K07E8.11 Member of the 7-transmembrane chemoreceptor family of G protein-coupled receptors (GPCR), has high similarity to uncharacterized C. elegans K07E8.9 7TM chemoreceptor, sri family K07E8.3 K07E8.3 Protein of unknown function, has moderate similarity to C. elegans R03H10.6 K07E8.5 K07E8.5 G protein-coupled receptor with weak similarity to human somatostatin receptor K07E8.5 encodes a homolog of the functionally active Fmrf Receptor (FR; CG2114) of D. melanogaster; it is thus possible that K07E8.5 is a receptor for one of the FMRF-like neurotransmitters in C. elegans (e.g., FLP-1 through FLP-12). K07E8.6 K07E8.6 Protein with moderate similarity to C. elegans W08F4.8 K07E8.7 K07E8.7 Member of the pseudouridine synthase family, which synthesize pseudouridine from uracil in RNA, has low similarity to pseudouridine synthase (S. cerevisiae Pus6p), which modifies cytoplasmic and mitochondrial tRNAs at position 31 This gene encodes a protein predicted by Eisenberg and coworkers, with 68% accuracy, to be mitochondrial. K07E8.8 K07E8.8 Protein of unknown function, has weak similarity to C. elegans K07E8.5 K07E8.9 K07E8.9 Member of the 7-transmembrane chemoreceptor family of G protein-coupled receptors (GPCR), has high similarity to uncharacterized C. elegans K07E8.11 7TM chemoreceptor, sri family K07F5.1 msp-81;K07F5.1 Major sperm protein involved in C. elegans spermatogenesis major sperm protein; msp-81 encodes a member of the major sperm protein family. K07F5.11 K07F5.11 Protein with similarity to human trophinin (TRO, cell adhesion protein possibly involved in embryo implantation), putative paralog of C. elegans T28H11.5 K07F5.12 K07F5.12;K07F5.12 Protein of unknown function, has low similarity to uncharacterized human FLJ11155 K07F5.13 K07F5.13 Protein of unknown function, has a region of low similarity to nucleoporin p54 (rat Nup54), which is a component of the p62 complex that is localized on both sides of the nuclear pore complex and binds to nuclear import factors rat Impnb and rat Rn.7345 K07F5.14 K07F5.14 Protein with strong similarity to C. elegans K07F5.15 gene product K07F5.15 K07F5.15 Protein with strong similarity to C. elegans K07F5.14 gene product The K07F5.15 gene encodes a small protein that is of ancient origin, and thus is presumably important to eukaryotic life; it is homologous to YNL024C-A (also known as NNL005C) in S. cerevisiae, and has homologs in Drosophila, mammals, and Neurospora, most of which are also small (<100-residue) proteins. K07F5.2 msp-10;K07F5.2 Member of the major sperm-specific protein (MSP) family major sperm protein; msp-10 encodes a protein that belongs to a family of proteins called the Major Sperm Proteins (MSPs) that is conserved in nematodes; this family consists of closely related, small, basic proteins that make up 15% of sperm protein; this multigene family consists of over fifty genes, including many pseudogenes; MSPs are involved in both extracellular signaling and cytoskeletal functions during reproduction-MSP antagonizes Eph/ephrin signaling, in part, by binding VAB-1 Eph receptor tyrosine kinase on oocytes and sheath cells to promote oocyte maturation and MAPK activation; MSPs assemble into fibrous networks that drive movement of the C. elegans sperm; msp genes are expressed only in late primary spermatocytes. K07F5.3 K07F5.3 Protein with very strong similarity to C. elegans MSP-10, which is involved in oocyte maturation, contains a major sperm protein (MSP) domain, which are involved in sperm motility major sperm protein; msp-56 encodes a protein that belongs to a family of proteins called the Major Sperm Proteins (MSPs) that is conserved in nematodes; this family consists of closely related, small, basic proteins that make up 15% of sperm protein; this multigene family consists of over fifty genes, including many pseudogenes; MSPs are involved in both extracellular signaling and cytoskeletal functions during reproduction-MSP antagonizes Eph/ephrin signaling, in part, by binding VAB-1 Eph receptor tyrosine kinase on oocytes and sheath cells to promote oocyte maturation and MAPK activation; MSPs assemble into fibrous networks that drive movement of the C. elegans sperm; msp genes are expressed only in late primary spermatocytes. K07F5.4 kin-24;cehd-8;K07F5.4 Putative tyrosine protein kinase, has similarity to human and D. melanogaster FER (fps/fes-related) protein kinases tyrosine-protein kinase K07F5.5 K07F5.5 Protein of unknown function K07F5.6 K07F5.6 Member of the protein-tyrosine phosphatase family, which are involved in control of cell growth, proliferation, differentiation and transformation, has a region of low similarity to C. elegans F10G8.1 protein-tyrosine phosphatase K07F5.7 K07F5.7 Protein containing a major sperm protein (MSP) domain, which are involved in sperm motility, has high similarity to uncharacterized C. elegans C25D7.1 K07F5.8 K07F5.8 Protein with high similarity to C. elegans F10G8.1, which is involved in embryogenesis or morphogenesis, member of the protein-tyrosine phosphatase family, which are involved in control of cell growth, proliferation, differentiation and transformation protein-tyrosine phosphatase K07F5.9 K07F5.9 Protein containing a major sperm protein (MSP) domain, which are involved in sperm motility, has very strong similarity to uncharacterized C. elegans SSP-11 major sperm protein K07G5.1 K07G5.1;ALP Protein containing four leucine rich repeats, which mediate protein-protein interactions Leucine Rich Repeat (2 copies) (4 domains) K07G5.2 K07G5.2 Member of the XPA protein family, which participate in DNA excision repair, has moderate similarity to xeroderma pigmentosum group A (human XPA), which is a zinc-binding nuclear DNA excision repair protein that provides UV protection DNA-repair protein XP-A homolog like; xpa-1 encodes an ortholog of human XPA, the xeroderma pigmentosum complementation group A protein (OMIM:278700, mutations are associated with sensitivity to ultraviolet light and carcinomata at an early age); by homology, XPA-1 is predicted to function as a DNA-binding protein that is required for nucleotide excision repair of damaged DNA; in C. elegans, loss of xpa-1 activity via mutation or RNA-mediated interference (RNAi) results in increased sensitivity to UV irradiation at all stages of development; xpa-1 mRNA is detected in eggs and mixed stage populations. K07G5.3 K07G5.3 Protein with weak similarity to S. cerevisiae YAL035W (Translation initiation factor 2 (eIF2)) C2 domain K07G5.4 K07G5.4 Protein of unknown function K07G5.5 K07G5.5 Member of the cation efflux family, which may be membrane divalent cation transporters, has moderate similarity to uncharacterized C. elegans PDB1.1 K07G5.6 K07G5.6 Protein of unknown function K07G6.A K07G6.1;K07G6.A Protein of unknown function, has moderate similarity to uncharacterized C. elegans R52.4 K07H8.1 K07H8.1 Putative tubulin-specific chaperone, has strong similarity to human TBCE (tubulin-specific chaperone E), has similarity to S. cerevisiae Pac2p K07H8.10 K07H8.10 Protein containing two RNA recognition motifs (RRM, RBD, or RNP) RNA-binding protein K07H8.2 K07H8.2 Member of the divalent cation transporter family, which may transport Mg2+ or other divalent cations into the cell, has high similarity to uncharacterized human DKFZP434K0427 K07H8.3 K07H8.3 Protein with high similarity to S. cerevisiae Ard1p, which is an N-acetyltransferase subunit in a complex with Nat1p and is required for transcriptional silencing at telomeres and transcriptional repression, contains an acetyltransferase (GNAT) domain K07H8.4 K07H8.4 Protein of unknown function K07H8.5 K07H8.5 Protein of unknown function, has moderate similarity to C. elegans F58D2.2 K07H8.6 vit-6;K07H8.6 Yolk proteins yp115 and yp88 vitellogenin K07H8.7 K07H8.7 Protein of unknown function, has strong similarity to C. elegans B0432.11 K07H8.8 K07H8.8 Member of an uncharacterized protein family K07H8.9 K07H8.9 Protein containing a KH domain, which may bind RNA, has moderate similarity to a region of C. elegans GLD-1, which is an RNA binding protein that is required for transition from mitosis to meiosis during spermatogenesis and oogenesis in hermaphrodites K08A2.1 K08A2.1 Protein of unknown function, putative paralog of C. elegans K08A2_45.G K08A2.2 K08A2_45.F;K08A2.F;K08A2.2 Protein of unknown function, has high similarity to uncharacterized C. elegans T09F5.10 K08A2.4 K08A2.4 Protein of unknown function, putative paralog of C. elegans K08A2_45.E K08A2.5 K08A2_45.D;K08A2.D;K08A2.5 Protein containing a nuclear hormone receptor ligand-binding domain, has a region of low similarity to a region of hepatocyte nuclear factor 4 gamma (mouse Hnf4g), which is involved in differential transcriptional regulation of HNF4-dependent genes transposase K08A2.6 K08A2_45.C;K08A2.C;K08A2.6 Member of the Tc3 Transposase protein family K08A2.7 nhr-88;K08A2.7 Putative paralog of C. elegans K08A2_45.B K08A8.1 mek-1;kin-17;mkk7;K08A8.1 MAP kinase kinase with strong similarity to H. sapiens MKK7 Map kinase kinase; mek-1 encodes a MAP kinase kinase (MAPKK) that is involved in the stress response to heavy metals and starvation, and that has the highest homology to mammalian MKK7. K08A8.2 K08A8.2 Protein containing a high mobility group box (HMG1 or 2) family domain, has a region of high similarity to a region of SRY box 2 (mouse Sox2), which is a transcriptional activator that may be involved in the induction of lens cell differentiation sex-determining protein SRY; The sox-2 gene encodes a homolog of human SRY, which when mutated leads to gonadal dysgenesis (OMIM:306100). K08A8.3 coh-1;K08A8.3 Sister chromatid cohesion protein; strongly similar to D. melanogaster Rad21 S. pombe double-strand-break repair protein, RAD21 K08B12.1 K08B12.1 Member of the lipase class 3 family, which are a subset of lipolytic enzymes that hydrolyze ester linkages of triglycerides, has low similarity to uncharacterized C. elegans F28H7.3 K08B12.2 K08B12.2 Protein containing two DM (dsx and mab-3) DNA binding domains K08B12.3 K08B12.3 Member of the haloacid dehalogenase or epoxide hydrolase family, has high similarity to human uncharacterized DKFZP564D1378 This gene encodes a protein predicted by Eisenberg and coworkers, with 52% accuracy, to be mitochondrial. K08B12.5 K08B12.5 Protein containing two phorbol esters or diacylglycerol binding domains, which bind two zinc ions, a pleckstrin homology, two protein kinase, two protein kinase C-terminal, and two regulatory citron homology domains, has moderate similarity to rat Pk428 serine/threonine-protein kinase; tag-59/K08B12.5 encodes a serine/threonine-protein kinase that is homologous to human DMK (OMIM:160900l; mutated in dystrophia myotonica I). K08B4.1 lag-1;K08B4.1 CBF1 homolog and a potential transcriptional regulator of the LIN-12 and GLP-1 (Lag) pathways DNA-binding protein; lag-1 encodes a transcription factor orthologous to members of the CSL (CBF1, Suppressor of Hairless, LAG-1) family that is highly conserved amongst metazoans; during development, LAG-1 functions as a downstream effector in both the lin-12- and glp-1-mediated Notch-like signaling pathways and accordingly, is required for such processes as germline induction, AC/VU lateral signaling, and embryonic development; LAG-1 can bind a consensus CSL family binding site found in multiple copies in the predicted regulatory regions of lin-12, glp-1, and lag-1, thus implicating LAG-1 as an important component of the positive feedback loop observed in the LIN-12/GLP-1 signaling pathway; LAG-1 is detected in all nuclei of the germ line except mature sperm, somatic gonad, and early embryo. K08B4.2 K08B4.2 Proein of unknown function K08B4.3 K08B4.3 Protein containing two UDP-glucoronosyl and UDP-glucosyl transferase domains, has weak similarity to UDP glycosyltransferase 1 A3 (human UGT1A3), which converts hydrophobic xenobiotic and endobiotic compounds to hydrophilic compounds glucuronosyltransferase K08B4.4 K08B4.4 Protein containing two UDP-glucoronosyl and UDP-glucosyl transferase domains, has low similarity to UDP glycosyltransferase 1 A3 (human UGT1A3), which converts hydrophobic xenobiotic and endobiotic compounds to hydrophilic compounds glucuronosyltransferase K08B4.5 K08B4.5 Member of the ubiquitin carboxyl-terminal hydrolase family 2, which are cysteine proteases involved in deubiquination K08B4.6 K08B4.6 Protein containing a cystatin domain, has high similarity to uncharacterized C. elegans R01B10.1 protease inhibitor; cli-2 encodes a homolog of cysteine protease inhibitors (cystatins); cli-2 is at least superficially dispensable for viability and gross morphology. K08B5.1 K08B5.1 Protein of unknown function K08B5.2 K08B5.2 Protein of unknown function K08C7.1 K08C7.1 Protein with similarity to human and D. melanogaster sodium-dependent inorganic phosphate cotransporters, member of the major facilitator superfamily sodium/phosphate transport protein K08C7.2 K08C7.2 Member of the flavin-binding monooxygenase family, which are xenobiotic-metabolising enzymes, has moderate similarity to flavin containing monooxygenase 5 (human FMO5) flavin-containing monoxygenase; The fmo-11 gene encodes a flavin-containing monoxygenase; fmo-11 is homologous to the human genes FMO1, FMO2, and FMO3, which when mutated lead to trimethylaminuria (OMIM:602079). K08C7.3 epi-1;lgx-3;K08C7.3 Laminin alpha chain laminin; epi-1 encodes a laminin alpha chain that affects oogenesis due to its affect on gonad development, and also affects cell migrations, axon extension and GABAergic defasciculation, morphology of the VD and DD motor neurons, body morphology, locomotion, gonad sheath epithelialization, body muscle structure, and germ cell proliferation. K08C7.4 K08C7.4 Protein of unknown function K08C7.5 K08C7.5 Member of the flavin-binding monooxygenase family, which are xenobiotic-metabolising enzymes, has moderate similarity to flavin containing monooxygenase 5 (human FMO5) flavin-containing monoxygenase K08C7.6 K08C7.6 Protein of unknown function K08C7.7 K08C7.7 Protein of unknown function This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins. K08C9.1 K08C9.1 Protein with strong similarity to C. elegans K08C9.2 gene product K08C9.2 K08C9.2 Protein with strong similarity to C. elegans K08C9.1 gene product K08C9.4 K08C9.4 Protein containing two collagen triple helix repeats, which are found in some extracellular proteins and a nematode cuticle collagen N-terminal domain, has moderate similarity to C. elegans DPY-7, which is cuticle collagen K08C9.5 K08C9.5 Protein containing an F-box domain, which serve as a link between a target protein and a ubiquitin-conjugating enzyme This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins. K08C9.6 K08C9.6 Protein of unknown function K08C9.7 K08C9.7 Protein of unknown function, has high similarity to uncharacterized C. elegans F34H10.1 Ubiquitin family K08D10.1 K08D10.1 Protein of unknown function, has very strong similarity to uncharacterized C. elegans K08F11.2 K08D10.10 K08D10.10 Protein of unknown function, has high similarity to uncharacterized C. elegans R07C12.1 K08D10.11 K08D10.11 Protein of unknown function, has strong similarity to uncharacterized C. elegans F58D12.1 K08D10.2 K08D10.2 Protein containing a DnaJ domain, which are part of the chaperone (protein folding) system that mediates interaction with heat shock proteins This gene encodes a protein containing a DnaJ ('J') domain. K08D10.3 K08D10.3 Protein with high similarity to U2 small nuclear ribonucleoprotein (snRN) B" (human SNRPB2), which is an snRNP- and snRNA-binding protein that is associated with some rheumatic diseases, contains two RNA recognition motifs (RRM, RBD, or RNP) U1 small nuclear ribonucleoprotein A K08D10.4 K08D10.4 Protein with high similarity to U2 small nuclear ribonucleoprotein (snRN) B" (human SNRPB2), which is an snRNP- and snRNA-binding protein that is associated with some rheumatic diseases, contains two RNA recognition motifs (RRM, RBD, or RNP) U1 small nuclear ribonucleoprotein A K08D10.5 K08D10.5 Protein with similarity to helicases, putative paralog of C. elegans R03D7.2 K08D10.6 K08D10.6 Protein with strong similarity to C. elegans F46A8.10 gene product K08D10.7 K08D10.7 Protein with low similarity to phospholipid scramblase 2 (mouse Plscr2), which mediates the calcium-dependent transbilayer movement of phospholipids and may be responsible for the redistribution of membrane phospholipids in damaged or apoptotic cells K08D10.7 encodes a homolog of human scramblase (PLSCR1; OMIM:604170), which is activated by a rise of intracellular calcium, and which promotes the exposure of phosphatidylserine on the surface of cells undergoing activation, injury, or apoptosis; a close paralog of K08D10.7 is K08D10.8, and other paralogs include F46A8.9, F46A8.10, and Y50E8A.9> Exposure of phosphatidylserine on the surface of apoptotic cells occurs because of a phospholipid scramblase and inactivation of an aminophospolipid translocase that would normally keep the PS on the interior of the cell; by virtue of its similarity to mammalian scramblase, K08D10.7 may promote clearage of apoptotic cells by phagocytosis. K08D10.8 K08D10.8 Protein with low similarity to plasma membrane phospholipid scramblase 1 (human PLSCR1), which mediates Ca2+-dependent movement of membrane phospholipids in activated, injured, or apoptotic cells and is a substrate of tyrosine kinase c-Abl K08D10.7 encodes a homolog of human scramblase (PLSCR1; OMIM:604170), which is activated by a rise of intracellular calcium, and which promotes the exposure of phosphatidylserine on the surface of cells undergoing activation, injury, or apoptosis; a close paralog of K08D10.8 is K08D10.7, and other paralogs include F46A8.9, F46A8.10, and Y50E8A.9> Exposure of phosphatidylserine on the surface of apoptotic cells occurs because of a phospholipid scramblase and inactivation of an aminophospolipid translocase that would normally keep the PS on the interior of the cell; by virtue of its similarity to mammalian scramblase, K08D10.8 may promote clearage of apoptotic cells by phagocytosis. K08D10.9 K08D10.9 Protein of unknown function, has high similarity to uncharacterized C. elegans R07C12.4 K08D12.1 pbs-1;K08D12.1 Putative beta-type subunit of 20S proteasome particle K08D12.2 K08D12.2 Protein of unknown function K08D12.2 is orthologous to the human gene XRP2 PROTEIN (RP2; OMIM:312600), which when mutated leads to disease. K08D12.3 K08D12.3 Protein with moderate similarity to C. elegans glh-2 gene product K08D12.3 is orthologous to the human gene UNNAMED PROTEIN PRODUCT (ZNF9; OMIM:116955), which when mutated leads to disease. K08D12.4 K08D12.4 Protein of unknown function K08D12.5 K08D12.5 Protein with weak similarity to C. elegans C47F8.6 gene product K08D8.1 K08D8.1 Protein of unknown function K08D8.2 K08D8.2 Protein of unknown function K08D8.3 K08D8.3 Protein containing a DUF141 domain of unknown function, has moderate similarity to uncharacterized C. elegans C32H11.1 K08D8.4 K08D8.4 Protein containing a DUF141 domain of unknown function, has high similarity to uncharacterized C. elegans C32H11.1 K08D8.5 K08D8.5 Protein containing a DUF141 domain of unknown function, has moderate similarity to uncharacterized C. elegans C32H11.12 K08D8.6 K08D8.6 Protein containing a DUF141 domain of unknown function, has high similarity to uncharacterized C. elegans F55C9.6 K08D9.1 K08D9.1 Member of the 7-transmembrane chemoreceptor family of G protein-coupled receptors (GPCR), has low similarity to uncharacterized C. elegans R11D1.6 K08D9.2 K08D9.2 Protein containing a DUF138 domain of unknown function, has moderate similarity to uncharacterized C. elegans T06A1.1 K08D9.3 apx-1;K08D9.3 Ligand for the GLP-1 receptor; induces the ABp cell fate apx-1 encodes one of ten C. elegans DSL (Delta, Serrate, LAG-2) proteins, transmembrane and secreted proteins containing DSL and EGF-like motifs that function as signaling ligands for the Notch-like receptors LIN-12 and GLP-1; as a GLP-1 ligand, APX-1 is required maternally for an inductive interaction in the 4-cell embryo that specifies the fate of the ABp blastomere; APX-1 is also required during the early 16E-cell stage of intestinal development for a LIN-12-dependent invariant, asymmetrical twist that is part of normal gut morphogenesis; further, APX-1 is required redundantly with LAG-2 and DSL-1 for a LIN-12-dependent lateral signal that spatially patterns the primary and secondary vulval cell lineages; in the embryo, antibody staining indicates that APX-1 is expressed in the signaling blastomere, P2, and normal levels and localization in P2 are dependent upon wild-type PIE-1 activity; in the vulval precursor cells, a transcriptional reporter fusion reveals expression in the primary vulval precursor P6.p that is dependent upon inductive signaling mediated by the LET-23-Ras pathway and wild-type activity of the SUR-2 transcriptional mediator component. | apx-1 encodes one of ten C. elegans DSL (Delta, Serrate, LAG-2) proteins, transmembrane and secreted proteins containing DSL and EGF-like motifs that function as signaling ligands for the Notch-like receptors LIN-12 and GLP-1; as a GLP-1 ligand, APX-1 is required maternally for an inductive interaction in the 4-cell embryo that specifies the fate of the ABp blastomere; APX-1 is also required during the early 16E-cell stage of intestinal development for a LIN-12-dependent invariant, asymmetrical twist that is part of normal gut morphogenesis; further, APX-1 is required redundantly with LAG-2 and DSL-1 for a LIN-12-dependent lateral signal that spatially patterns the primary and secondary vulval cell lineages; in the embryo, antibody staining indicates that APX-1 is expressed in the signaling blastomere, P2, and normal levels and localization in P2 are dependent upon wild-type PIE-1 activity; in the vulval precursor cells, a transcriptional reporter fusion reveals expression in the primary vulval precursor P6. K08D9.4 K08D9.4 Protein of unknown function, has strong similarity to uncharacterized C. elegans Y73C8B.1 K08D9.5 K08D9.5 Protein containing a DUF23 domain of unknown function K08D9.6 K08D9.6 Protein containing two DUF23 domains of unknown function, has high similarity to uncharacterized C. elegans C13A2.6 K08E3.1 K08E3.1 Protein containing two tyrosinase central domains, which bind copper, has a region of low similarity to a region of tyrosinase (mouse Tyr), which is required for melanin synthesis and is associated with causes classic type I oculocutaneous albinism tyrosinase K08E3.2 K08E3.2 Protein containing a major sperm protein (MSP) domain, which are involved in sperm motility, has moderate similarity to uncharacterized C. elegans F36H12.3 K08E3.3 K08E3.3 Protein containing two Src homology 3 (SH3) domains, which bind proline-rich peptides, two Fes or CIP4 homology domains, and two EF hand domains, has weak similarity to formin binding protein 1 (human FBP17), which may mediate protein complex assembly EF hand, Src homology domain 3 K08E3.4 K08E3.4 Member of the cofilin or tropomyosin-type actin-binding protein family, which depolymerize actin filaments and bind actin, contains a Src homology 3 (SH3) domain, has low similarity to human HIP-55, which is an SH3 adaptor protein that may bind actin Cofilin/tropomyosin-type actin-binding proteins, Src homology domain 3 K08E3.5 K08E3.5 Protein with high similarity to UDP-glucose pyrophosphorylase 2 (human UGP2), which catalyzes the formation of UDP-glucose from glucose-1-phosphate and MgUTP, member of the UTP-glucose-1-phosphate uridylyltransferase family UTP--GLUCOSE-1-PHOSPHATE URIDYLYLTRANSFERASE (EC 2.7.7.9) (UDP-GLUCOSE PYROPHOSPHORYLASE) (UDPGP) K08E3.6 cyk-4;K08E3.6 Required for completion of mitosis Phorbol esters/diacylglycerol binding domain (C1 domain), GTPase-activator protein for Rho-like GTPases; cyk-4 encodes a GTPase activating protein (GAP) for the Rho family of GTPases that, together with ZEN-4, is sufficient to promote the formation of the large bundles of microtubules that form the central spindle during anaphase, and is required for fertility and coordinated locomotion postembryonically; localizes to the central spindle during anaphase interdependently with ZEN-4, and interacts with ZEN-4 in vitro and in vivo. K08E3.7 K08E3.7;Parkin Protein with low similarity to Parkinson disease (autosomal recessive, juvenile) 2 (human PARK2), which is a ubiquitin-protein ligase that functions to ubiquinate human SNCA, human SNCAIP, and human PNUTL1, and is associated with juvenile Parkinsonism pdr-1 encodes an ortholog of human parkin (PARK2; OMIM:602544), which when mutated leads to the juvenile 2 form of Parkinson disease (OMIM:600116). K08E3.8 K08E3.8 Putative ortholog of C. elegans 3R5.2 gene product K08E4.1 K08E4.1 Protein with moderate similarity to suppressor of Ty (S.cerevisiae) 5 homolog (human SUPT5H), which is part of the DRB sensitivity inducing factor that regulates transcription elongation that stimulates mRNA capping and is required for HIV-1 transcription translation initiation protein SPT5 like K08E4.2 K08E4.2 Protein of unknown function, has low similarity to uncharacterized mouse BC002216 K08E4.3 K08E4.3 Protein of unknown function K08E4.4 K08E4.4 Protein of unknown function K08E4.5 K08E4.5 Protein containing one BTB (BR-C, ttk and babor) or POZ (Pox virus and zinc finger) domain, which are found in some DNA and actin binding proteins and may mediate protein-protein interactions K08E4.6 K08E4.6 Member of the emp24 family, which are involved in protein transport from endoplasmic reticulum to Golgi, has moderate similarity to T1-ST2 receptor binding protein (human IL1RL1LG), which binds to human IL1RL1 and may be involved in signal transduction emp24/gp25L/p24 family K08E5.2 K08E5.2 Member of the Sodium:sulfate symporter family of membrane transporters, has moderate similarity to sodium-dependent dicarboxylate cotransporter (solute carrier family 13 member 2, rat Slc13a2), which reabsorbs Krebs cycle intermediates Yeast ORF YCR37C K08E5.3 K08E5.3 LDL receptor-related protein, has similarity to C. elegans LRP-1, contains a putative EGF-repeat domain LDL receptor related protein, EGF and CMP repeats K08E7.1 K08E7.1 Protein of unknown function K08E7.2 hsb-1;K08E7.2 Heat shock factor binding protein K08E7.3 let-99;K08E7.3 Protein that may act to establish embryonic polarity, contains a Dishevelled/Egl-10/Pleckstrin domain Domain found in Dishevelled, Egl-10, and Pleckstrin; let-99 encodes a protein with a DEP domain (Domain found in Dishevelled, Egl-10, and Pleckstrin); LET-99 has no obvious homologs in non-nematodes, but has a truncated paralog (LRG-1) in C. elegans; LET-99 is required for the mitotic spindle to be properly oriented with respect to the axis of cellular polarity, both during anterior migration and rotation of the nuclear-centrosome complex and during anaphase; let-99 mutants exhibit hyperactive nuclear movement and abnormal anaphase spindle pole behavior; LET-99 is mislocalized in par-2 and par-3 mutants; like other proteins containing DEP domains, LET-99 may act as part of a G protein signalling pathway (e.g., the one controlling spindle position). K08E7.4 K08E7.4 Protein with strong similarity to C. elegans Y53F4A.2 gene product K08E7.5 K08E7.5 Protein of unknown function, has a region of weak similarity to a region of a cell surface flocculin (S. cerevisiae Muc1p), which is required for invasive and pseudohyphal growth K08E7.6 K08E7.6 Protein of unknown function K08E7.7 cul-6;K08E7.7 Protein with high similarity to C. elegans CUL-1, which is a cell cycle control protein, member of the cullin family LIN-19 like protein; cul-6 encodes a member of the cullin family that may physically interact with SKR-3. K08E7.8 K08E7.8 Protein containing three leucine rich repeats, which mediate protein-protein interactions Leucine Rich Repeat (2 copies) (2 domains) K08E7.9 pgp-1;K08E7.9 P-glycoprotein of intestinal cells, multidrug resistance protein of the ATP-binding cassette (ABC) superfamily, has strong similarity to human, Drosophila, and S. cerevisiae multidrug resistance proteins multidrug resistance protein; pgp-1 encodes a transmembrane protein that is a member of the P-glycoprotein subclass of the ATP-binding cassette (ABC) transporter superfamily; along with PGP-3, PGP-1 is required for defense against the pathogenic Pseudomonas aeruginosa strain PA14, and may facilitate ATP-dependent efflux of the toxic phenazine compounds produced by the bacteria; PGP-1 is expressed in the apical membrane of intestinal cells and in the intestinal valve cells; loss of pgp-1 activity via large-scale RNAi screens does not result in any obvious abnormalities. K08F11.1 K08F11.1 Protein of unknown function K08F11.2 K08F11.2 Protein of unknown function, has very strong similarity to uncharacterized C. elegans K08D10.1 K08F11.3 K08F11.3 Protein of unknown function, has low similarity to uncharacterized human GA17 K08F11.4 K08F11.4 Member of the class I tryptophanyl and tyrosyl (W and Y) tRNA synthetase family, has low similarity to S. cerevisiae Msy1p, which is a mitochondrial tyrosyl-tRNA synthetase tyrosyl-tRNA synthetase; yrs-1 encodes a tyrosinyl tRNA synthetase predicted to be mitochondrial. K08F11.5 K08F11.5 Protein containing two EF hand domains, which are found in signaling, buffering or transport proteins, has high similarity to uncharacterized C. elegans C47C12.4 RAS-related protein K08F4.1 K08F4.1 Protein of unknown function, has a region of weak similarity to S. cerevisiae Ctf18p, which is required for accurate chromosome transmission in mitosis and maintenance of normal telomere length and may play a role in sister chromatid cohesion Yeast Chl2p like K08F4.11 gst-3;CeGST3;K08F4.11 Protein containing glutathione S-transferase N-terminal and C-terminal domains, has low similarity to prostaglandin D2 synthase (human PGDS), which is a prostaglandin D synthase and glutathione S-transferase that regulates non-rapid eye movement sleep glutathione S-transferase; gst-3 encodes a predicted glutathione S-transferase. K08F4.2 K08F4.2 Protein containing a nuclear transport factor 2 (NTF2) domain, which facilitate protein transport into the nucleus, and an RNA recognition motif (RRM, RBD, or RNP) RNA recognition motif. (aka RRM, RBD, or RNP domain) K08F4.3 K08F4.3 Protein of unknown function, has low similarity to uncharacterized signal sequence receptor beta (translocon-associated protein beta, human SSR2), which is the putative beta subunit of the signal sequence receptor complex translocon-associated protein K08F4.4 K08F4.4 Protein with high similarity to C. elegans GLT-2, which is a glutamate transporter, member of the sodium:dicarboxylate symporter family of membrane transporters excitatory amino acid transporter 2 like; glt-3 encodes an ortholog of glutamate/aspartate and neutral amino acid transporters. K08F4.5 K08F4.5 Protein of unknown function K08F4.6 gst-2;CeGST2;K08F4.6 Protein containing glutathione S-transferase N-terminal and C-terminal domains, has low similarity to prostaglandin D2 synthase (human PGDS), which is a prostaglandin D synthase and glutathione S-transferase that regulates non-rapid eye movement sleep glutathione S-transferase K08F4.7 gst-4;K08F4.7;CeGST1 Protein containing glutathione S-transferase N-terminal and C-terminal domains, has moderate similarity to prostaglandin D2 synthase 2 (hematopoietic) (mouse Ptgds2), which is both a prostaglandin D synthase and a glutathione S-transferase glutathione S-transferase; gst-4 encodes a predicted glutathione S-transferase; mRNA is expressed in adults and accumulation increases in response to paraquat. K08F4.8 msp-38;K08F4.8 Sperm-specific protein involved in sperm motility, member of the major sperm protein (MSP) family major sperm protein MSP-38; msp-38 encodes a member of the major sperm protein family. K08F4.9 K08F4.9 Member of the alcohol dehydrogenase protein family alcohol dehydrogenase K08F8.1 K08F8.1 Serine/threonine protein kinase with strong similarity to human and D. melanogaster mitogen-activated protein kinase-activated protein kinases (MAPKAPKs) ribosomal S6 kinase K08F8.2 K08F8.2 Protein containing a bZIP (basic-leucine zipper) transcription factor domain, has weak similarity to nuclear factor interleukin 3-regulated (mouse Nfil3), which is a transcription factor that mediates pro-B lymphocyte survival transcription factor K08F8.3 CEFT-1;K08F8.3 Alpha1,3 fucosyltransferase fucosyltransferase; fut-1 encodes a functional fucosyl transferase; evidence from biophysical experiments indicates that FUT-1 is a golgi-localized glycosyltransferase. K08F8.4 bas-2;K08F8.4 Putative phenylalanine hydroxylase and ortholog of human phenylalanine hydroxylase phenylalanine-4-hydroxylase (PH4H); The bas-2 gene encodes an ortholog of the human gene PHENYLALANINE HYDROXYLASE (PAH), which when mutated leads to phenylketonuria (OMIM:261600). K08F8.5 K08F8.5 Protein of unknown function, has low similarity to uncharacterized C. elegans Y69E1A.B K08F8.6 K08F8.6 Protein with weak similarity to thyroid hormone receptor associated protein 240 (human TRAP240), which is a subunit of TRAP/SMCC complex and coactivates ligand-dependent thyroid hormone receptor and p53 (TP53)-mediated transcription The let-19 gene encodes a protein related to human TRAP240 (thyroid hormone receptor-associated protein 240, OMIM:300182), a transcriptional co-activation complex subunit conserved in yeast, Drosophila, and humans; LET-19 is required for proper asymmetric cell divisions and cell fusions regulated by LIN-44/Wnt and LIN-17/frizzled, as well as for proper development of secondary vulval cell fates as regulated by Notch signaling. K08F9.1 K08F9.1 Protein with high similarity to C. elegans C35A11.4, which is involved in embryogenesis and morphogenesis, member of the sugar (and other) transporter family glucose transporter K08F9.2 K08F9.2 Protein with high similarity to C. elegans UNC-78, which is required for appropriate muscle structure development, contains ten WD domain (WD-40 repeat), which may mediate protein-protein interactions beta-transducin like protein K08F9.3 K08F9.3 Protein with moderate similarity to C. elegans T19H5.1 gene product chitinase K08F9.4 K08F9.4 Protein of unknown function K08G2.2 K08G2.2 Member of the 7-transmembrane chemoreceptor family of G protein-coupled receptors (GPCR), has high similarity to uncharacterized C. elegans F40D4.3 K08G2.5 K08G2.5 Member of the 7-transmembrane chemoreceptor family of G protein-coupled receptors (GPCR), has moderate similarity to uncharacterized C. elegans D1054.12 K08G2.6 K08G2.6 Member of the 7-transmembrane chemoreceptor family of G protein-coupled receptors (GPCR), has high similarity to uncharacterized C. elegans F40D4.3 K08G2.7 K08G2.7 Protein containing a DUF216 domain of unknown function, has low similarity to uncharacterized C. elegans C08F11.9 K08G2.8 K08G2.8 Member of the 7-transmembrane chemoreceptor family of G protein-coupled receptors (GPCR), has weak similarity to uncharacterized C. elegans T21B4.10 K08H10.1 lea-1;lea;K08H10.1 Protein containing nine late embryogenesis abundant (LEA) protein domains, which are expressed under conditions of dehydration stress The lea-1 gene encodes a protein that is predicted to be hydrophilic and heat-resistant, and that might participate in anhydrobiosis. K08H10.2 K08H10.2 Protein containing five late embryogenesis abundant (LEA) protein domains, which are expressed under conditions of dehydration stress The K08H10.2 gene encodes a protein (K08H10.2A) that is predicted to be hydrophilic and heat-resistant, and that might participate in anhydrobiosis. K08H10.3 K08H10.3 Protein of unknown function K08H10.4 K08H10.4 Member of the GDA1 or CD39 family of nucleoside phosphatases, has moderate similarity to mouse Entpd5, which is an ectonucleoside triphosphate diphosphohydrolase that hydrolyzes UDP to UMP GDA1/CD39 (nucleoside phosphatase) family K08H10.6 K08H10.6 Member of the sugar (and other) transporter family, has low similarity to C. elegans C35A11.4 Sugar (and other) transporters K08H10.7 rde-1;K08H10.7 Protein involved in the mechanism of RNA-mediated gene silencing; has similarity to rabbit eIF2C, Arabidopsis ZWILLE, and D. melanogaster Sting K08H10.8 K08H10.8 Putative ortholog of S. cerevisiae Yer156p, a nonessential protein of unknown function K08H10.9 K08H10.9 Protein of unknown function, has low similarity to a region of S. cerevisiae Trs33p, which is a subunit of both the transport protein particle I (TRAPPI) and II (TRAPPII) complexes involved in endoplasmic reticulum to golgi transport and golgi trafficking K08H2.1 skr-21;K08H2.1 Member of the Skp1 family, which are required for targeted protein degradation during the cell cycle, has low similarity to uncharacterized C. elegans Y47D7A.1 RNA polymerase II elongation factor like; The skr-21 gene encodes a homolog of Skp1 in S. cerevisiae that has no known function in vivo, since skr-21(RNAi) animals are at least superficially normal. K08H2.2 K08H2.2 Protein with moderate similarity to C. elegans K08H2.3 gene product K08H2.3 K08H2.3 Protein of unknown function, has weak similarity to C. elegans K08H2.2 K08H2.4 K08H2.4 Protein of unknown function, has weak similarity to C. elegans K08H2.3 K08H2.5 K08H2.5 Serine/threonine protein kinase with weak similarity to protein kinases of human, D. melanogaster, and S. cerevisiae serine/threonine kinase K08H2.6 hpl-1;K08H2.6 Protein containing a Chromo shadow domain and a Chromo domain, which bind chromatin, has moderate similarity to chromobox homolog 3 (mouse Cbx3), which is involved in gene silencing, nuclear membrane assembly and transcriptional repression murine modifier 2 protein like; The hpl-1 gene encodes a homolog of heterochromatin protein 1 (HP1) that acts to support the activity of HPL-2 in promoting germline function, but that by itself is dispensable for any obvious function in vivo. K08H2.7 K08H2.7 Protein of unknown function K08H2.8 K08H2.8 Protein containing nuclear hormone receptor C4-type zinc finger domain and nuclear hormone receptor ligand-binding domain, has low similarity to hepatocyte nuclear factor 4 gamma (human HNF4G), which is involved in differential transcriptional regulation Zinc finger, C4 type (two domains) K09A11.1 K09A11.1 Member of the transposase protein family transposase K09A11.2 K09A11.2 Member of the cytochrome P450 family, has low similarity to cytochrome P450 subfamily 2C polypeptide 8 (mephenytoin 4-hydroxylase, human CYP2C8), which is a heme-binding monooxygenase that metabolizes steroids, fatty acids and xenobiotics cytochrome p450 K09A11.3 K09A11.3 Member of the cytochrome P450 family, has low similarity to cytochrome P450 subfamily 2E polypeptide 1(mouse Cyp2e1), which is an ethanol-inducible monooxygenase involved in xenobiotic, lipid, and drug metabolism, and in cytotoxicity Cytochrome P450 K09A11.4 K09A11.4 Member of the cytochrome P450 family, has low similarity to cytochrome P450 subfamily 2D polypeptide 6 (debrisoquine hydroxylase, human CYP2D6), which is a monooxygenase associated with ankylosing spondylitis and basal cell carcinoma cytochrome p450 K09A11.5 K09A11.5 Protein containing a PHD-finger, which may be involved in chromatin-mediated transcriptional regulation, has weak similarity to uncharacterized C. elegans F17A2.3 PHD-finger. K09A9.1 K09A9.1 Protein containing a protein kinase domain serine/threonine kinase K09A9.2 K09A9.2 Protein with high similarity to ras-related GTP-binding protein 2 (mouse Rab2), which plays a role in neuronal cell adhesion and may play a role in vesicle transport, member of the Ras superfamily of GTP binding proteins RAS-related protein; rab-14 encodes a member of the Rab GTPase family. K09A9.3 K09A9.3 Member of the nucleoside transporter family, which transport nucleosides across the plasma, and possibly nuclear, membrane, has low similarity to equilibrative nucleoside transporter 1 (human SLC29A1), which transports nucleosides K09A9.4 K09A9.4 Member of the ubiquitin carboxyl-terminal hydrolase family 2, which are cysteine proteases involved in deubiquination, contains a ubiquitin carboxyl-terminal hydrolases family 2 domain, has low similarity to S. cerevisiae Ubp8p ubiquitin caroboxyl-terminal hydrolase K09A9.5 gas-1;K09A9.5 Component of mitochondrial Complex I NADH dehydrogenase NADH-ubiquinone oxidoreductase 49KD subunit; The gas-1 gene encodes a predicted subunit of the mitochondrial electron transport complex I that is involved in anesthetic sensitivity, fecundity, and lifespan. K09A9.6 K09A9.6 Protein with low similarity to aspartyl beta-hydroxylase (human ASPH), which hydroxylates Asp/Asn in EGF domains and that binds calcium and calsequestrins and ryanodine receptor and that is associated with malignant transformation aspartyl beta hydroxylase like K09B11.1 pik-1;K09B11.1 Protein containing two protein kinase domains and one death domain, which mediate protein-protein interactions, has low similarity to interleukin-1 receptor-associated kinase M (human IRAK-M), which plays a role in signal transduction Eukaryotic protein kinase domain; The pik-1 gene encodes a pelle/IRAK kinase homolog that may be involved in apoptosis. K09B11.10 K09B11.10 Protein with strong similarity to C. elegans C47E12.6 gene product K09B11.2 K09B11.2 Protein of unknown function K09B11.3 K09B11.3 Protein of unknown function K09B11.4 K09B11.4 Putative ortholog of C. elegans T01A4.3 gene product K09B11.5 K09B11.5 Protein containing one protein kinase domain and one Src homology 2 (SH2) domain, which are regulatory modules of intracellular signaling, has low similarity to csk homologous kinase (rat Matk), which is a non-receptor protein tyrosine kinase Eukaryotic protein kinase domain K09B11.9 K09B11.9 Protein of unknown function K09B3.1 K09B3.1 Protein of unknown function K09B3.2 K09B3.2 Protein with strong similarity to C. elegans C47F8.4 gene product K09C4.1 K09C4.1 Member of the sugar (and other) transporter family, has weak similarity to glucose trasporter 4 (mouse Slc2a4), which plays a role in carbohydrate metabolism and is associated with insulin resistance and diabetes upon gene mutation glucose transporter K09C4.10 K09C4.10 Protein with weak similarity to S. cerevisiae NSP1 (Nuclear pore protein (nucleoporin) with XFXFG motifs) K09C4.2 K09C4.2 Protein with moderate similarity to C. elegans F11D5.5 gene product K09C4.3 hsp-2;K09C4.3 Member of the heat shock HSP70 protein family K09C4.4 K09C4.4 Putative ortholog of C. elegans K09C4.1 gene product sugar transporter K09C4.5 K09C4.5 Member of the sugar (and other) transporter family, has weak similarity to C. elegans C35A11.4 sugar transporter K09C4.6 K09C4.6 Protein of unknown function K09C4.7 K09C4.7 Protein of unknown function K09C4.8 K09C4.8 Member of the sulfatase family, has a region of moderate similarity to a region of N-acetylglucosamine-6-sulphate sulphatase (human GNS), which hydrolyzes sulfate groups from glycosaminoglycans and is associated with Sanfilippo disease IIID sulfatase; sul-1 encodes a member of the sulfatase family. K09C4.9 K09C4.9 Protein of unknown function K09C6.1 K09C6.1 Putative ortholog of C. elegans C28A5.6 gene product K09C6.2 K09C6.2 Protein with strong similarity to C. elegans C28A5.6 gene product K09C6.3 K09C6.3 Protein with moderate similarity to C. elegans D2096.9 gene product K09C6.4 K09C6.4 Protein containing a DUF40 domain of unknown function, which contain four conserved cysteines, has high similarity to uncharacterized C. elegans K09C6.5 K09C6.5 K09C6.5 Protein containing a DUF40 domain of unknown function, which contain four conserved cysteines, has high similarity to uncharacterized C. elegans K09C6.4 K09C6.6 K09C6.6 Putative ortholog of C. elegans F41H8.1 gene product K09C6.7 K09C6.7 Putative ortholog of C. elegans K09C6.8 gene product K09C6.8 K09C6.8 Putative ortholog of C. elegans T10B5.2 gene product K09C6.9 K09C6.9 Protein of unknown function, has high similarity to uncharacterized C. elegans T02B11.4 K09C8.1 K09C8.1 Member of the sodium or hydrogen exchanger family, which maintain the pH of actively metabolizing cells, has low similarity to sodium-hydrogen exchanger 1 (mouse Slc9a1), which is an antiporter that plays a role in pH and cell volume regulation Na(+)/H(+) exchanger; pbo-4 encodes a sodium/proton exchanger (also known as nhx-7), with a potential Ca[2+]/calmodulin binding domain in its C-terminal cytosolic region that could mediate calcium signaling; PBO-4 is expressed in the basolateral membrane of posterior intestinal cells; PBO-4 is required for normal posterior body muscle contraction (pBoc) during the defecation cycle; PBO-4 is thought to prevent intracellular acidification by catalysing the electroneutral exchange of extracellular sodium for an intracellular proton; specifically, PBO-4 may enable intercellular signals from intestinal cells (by secreting protons which then might activate PBO-5 in adjacent muscle cells). K09C8.2 K09C8.2 Neuropeptide neurotransmitter K09C8.3 K09C8.3 Putative paralog of C. elegans K11G12.1, has similarity to C. elegans TOH-2, a member of the CUB domain protein family metalloprotease K09C8.4 K09C8.4 Member of the glycosyl transferase family 8, has low similarity to acetylglucosaminyltransferase-like protein (mouse Large), which is an N-acetylglucosaminyltransferase that functions in protein glycosylation and may contribute to myodystrophy K09C8.5 K09C8.5 Member of the animal heme peroxidase family, contains four leucine rich repeats, two immunoglobulin domains, and a leucine rich repeat N-terminal cysteine rich domain, has moderate similarity to melanoma associated gene (human D2S448) peroxidase K09D9.11 K09D9.11 Protein with similarity to BRCA1 C Terminus (BRCT) domain K09D9.12 K09D9.12 Putative ortholog of C. elegans F16B12.6 gene product K09D9.2 K09D9.J;K09D9.2 Member of the cytochrome P450 family, has low similarity to cytochrome P450 subfamily IIC (mephenytoin 4-hydroxylase) polypeptide 9 (human CYP2C9), which has tolbutamide hydroxylase and phenacetin O deethylase activities and roles in xenobiotic metabolism cytochrome P450 K09D9.3 K09D9.I;K09D9.3 Protein of unknown function K09D9.9 K09D9.9 Protein of unknown function K09D9.B K09D9.10;K09D9.B Member of the rhodopsin family of G-protein coupled receptors (GPCR), has high similarity to uncharacterized C. elegans K07C6.7 K09D9.E K09D9.8;K09D9.E Member of the 7-transmembrane chemoreceptor family of G-protein coupled receptors (GPCR), has high similarity to uncharacterized C. elegans K09D9.7 K09D9.F K09D9.7;K09D9.F Member of the 7-transmembrane chemoreceptor family of G-protein coupled receptors (GPCR), has high similarity to uncharacterized C. elegans K09D9.8 K09D9.G K09D9.6;K09D9.G Protein of unknown function, has high similarity to uncharacterized C. elegans K04F1.5 K09D9.K K09D9.1;K09D9.K Protein of unknown function, has low similarity to uncharacterized C. elegans C49G7.5 K09E10.1 K09E10.1 Protein containing a DUF33 domain of unknown function, has high similarity to uncharacterized C. elegans K09E10.2 K09E10.2 K09E10.2 Protein containing a DUF33 domain of unknown function, has high similarity to uncharacterized C. elegans K09E10.1 K09E10.3 K09E10.3 Member of the transposase family, which are required for excising and inserting mobile genetic elements, has very strong similarity to uncharacterized C. elegans C29E6.6 transposase K09E2.1 K09E2.1 Protein containing a von Willebrand factor (vWF) type A domain K09E2.2 K09E2.2 Protein of unknown function K09E2.3 K09E2.3 Protein of unknown function K09E2.4 K09E2.4 Protein containing four immunoglobulin (Ig) domains and two fibronectin type III domains, has a region of weak similarity to a region of roundabout (axon guidance receptor, Drosophila) homolog 2 (human ROBO2), which is involved in axon guidance K09E3.1 K09E3.1 Putative ortholog of C. elegans Y43F4A.2 gene product S. lavendulae subtilisin inhibitor-like protein-4 (SIL-4) K09E3.2 K09E3.2 Protein of unknown function K09E3.3 K09E3.3 Protein of unknown function K09E3.4 K09E3.4 Protein of unknown function K09E3.5 K09E3.5 Protein of unknown function, has high similarity to uncharacterized C. elegans C08A9.9 K09E3.6 K09E3.6 Protein of unknown function, has low similarity to uncharacterized C. elegans C08A9.6 K09E3.7 K09E3.7 Putative ortholog of C. elegans T23C6.3 gene product K09E4.1 K09E4.1 Protein of unknown function, has weak similarity to uncharacterized C. elegans C08F8.6 K09E4.2 K09E4.2 Protein of unknown function, has a region of low similarity to S. cerevisiae Rhk1p, which is a mannosyltransferase that is involved in N-glycosylation and is a Hansenula mrakii HM-1 killer toxin resistance protein K09E4.3 K09E4.3 Protein of unknown function, has moderate similarity to uncharacterized C. albicans Orf6.3919p K09E4.4 K09E4.4 Protein with moderate similarity to alpha-N-acetylglucosaminidase (Sanfilippo disease IIIB, human NAGLU), which catalyzes the stepwise degradation of heparan sulfate and is associated with Sanfilippo syndrome type B upon mutation K09E4.4 is orthologous to the human gene N-ACETYLGALACTOSAMINIDASE, ALPHA- (NAGLU; OMIM:104170), which when mutated leads to disease. K09E4.5 K09E4.5 Protein of unknown function, has moderate similarity to uncharacterized C. elegans ZK622.2 K09E9.1 K09E9.1 Member of the sugar (and other) transporter family, has weak similarity to organic cation-carnitine transporter 3 (mouse Slc22a9), which is a a sodium and pH-independent organic cation and carnitine transporter that may be involved in spermatogenesis Sugar (and other) transporters K09E9.2 K09E9.2 Protein with low similarity to S. cerevisiae Erv46p, which is a component of COPII-coated vesicles that is involved in vesicular transport between the endoplasmic reticulum and the Golgi apparatus Yeast YAE2 hypothetical protein K09E9.3 K09E9.3 Protein of unknown function K09F5.1 K09F5.1 Protein with weak similarity to C. elegans R03D7.4 (Elongin B) K09F5.2 vit-1;K09F5.2 Member of the Vitellogenin worm-specific protein family; pseudogene of vit-2 vit-1 K09F5.3 uvt-1;K09F5.3 Protein of unknown function, has a region of high similarity to a region of C. elegans T08A9.9, which is an antibacterial peptide K09F5.4 K09F5.4 Protein of unknown function K09F5.5 K09F5.5 Protein containing a SET domain, has a region of moderate similarity to a region of S. cerevisiae Set2p, which is a histone methyltransferase specific for lysine 36 of histone H3 and is involved in repression Zinc finger protein HRX K09F6.1 K09F6.1 Protein of unknown function, has high similarity to uncharacterized C. elegans F54H12.4 K09F6.2 K09F6.2 Putative ortholog of C. elegans C17B7.7 gene product K09F6.3 K09F6.3 Member of the protein-tyrosine phosphatase family, which are involved in control of cell growth, proliferation, differentiation and transformation, has moderate similarity to uncharacterized C. elegans C40A11.5 protein-tyrosine phosphatase K09F6.4 K09F6.4 Protein containing a WSN domain of unknown function K09F6.5 K09F6.5 Protein of unknown function, has strong similarity to uncharacterized C. elegans F54H12.2 K09F6.6 K09F6.6 Putative ortholog of C. elegans F57C9.4 gene product K09F6.7 K09F6.7 Member of an uncharacterized protein family K09F6.8 K09F6.8 Protein of unknown function, has high similarity to uncharacterized C. elegans F58E1.12 K09G1.1 K09G1.1 Protein of unknown function, has weak similarity to C. elegans F28H1.4 K09G1.2 K09G1.2 Protein of unknown function K09G1.3 K09G1.3 Protein of unknown function K09G1.4 K09G1.4 Member of the rhodopsin family of G protein-coupled receptors (GPCR), has low similarity to dopamine D2 receptor (mouse Drd2), which inhibits adenylyl cyclase and glutamaterigic neurotransmission and is important for locomotory behavior dopamine receptor like; dop-2 is orthologous to the human gene DOPAMINE RECEPTOR D2 (DRD2; OMIM:126450), which when mutated leads to myoclonus-dystonia syndrome. K09H11.1 K09H11.1 Protein containing a putative acyl-CoA dehydrogenase domain, has strong similarity at the C-terminus to human ACADSB, an acyl-CoA dehydrogenase K09H11.2 K09H11.2 Protein of unknown function, has moderate similarity to uncharacterized C. elegans F32H5.6 K09H11.3 K09H11.3 Protein containing a RhoGAP (GTPase activator protein) domain, has high similarity to uncharacterized C. elegans Y75B7AL.4 K09H11.4 K09H11.4 Protein of unknown function, has weak similarity to C. elegans C09G5.6 K09H11.5 K09H11.5 Protein of unknown function K09H11.6 K09H11.6 Protein of unknown function K09H11.7 K09H11.7 Member of the haloacid dehalogenase or epoxide hydrolase family, has moderate similarity to S. cerevisiae Pho13p, which is a 4-nitrophenylphosphatase nitrophenylphosphatase K09H9.1 K09H9.1 Protein of unknown function, has a region of low similarity to a region of C. elegans PHA-1, which is involved in pharyngeal development K09H9.2 K09H9.2 Protein of unknown function K09H9.3 K09H9.3 Protein containing two collagen triple helix repeats, which are found in some extracellular proteins and a nematode cuticle collagen N-terminal domain, has a region of high similarity to a region of collagen type IX alpha 2 subunit (mouse Col9a2) cuticular collagen K09H9.4 K09H9.4 Member of the reverse transcriptase protein family, which are RNA-dependent DNA polymerases, has strong similarity to uncharacterized C. elegans C29F5.6 reverse transcriptase K09H9.5 K09H9.5 Protein with moderate similarity to C. elegans Y43F8B.C gene product K09H9.6 K09H9.6 Protein with low similarity to peter pan homolog (human PPAN), which suppresses anchorage-dependent cell growth and is associated with granulocytic differentiation in promyelocytic leukemia cells K09H9.7 K09H9.7 Protein of unknown function K10B2.1 lin-23;stu-1;K10B2.1 F-box/WD-repeat protein; required for regulating cell proliferation Transducin beta chain; lin-23 encodes an F-box- and WD-repeat-containing protein that is orthologous to Saccharomyces cerevisiae MET30 and human beta TRCP (OMIM:603482), both components of the SCF (Skp1, Cullin, F-box) ubiquitin-ligase complex that regulates ubiquitin-mediated protein degradation; LIN-23 negatively regulates postembryonic cell divsions in all tissue types, and specifically, has been shown to function cell autonomously in the vulva to negatively regulate cell cycle progression and allow for cell cycle exit; LIN-23 is most highly expressed in the early embryo and adult germline. K10B2.2 K10B2.2 Member of the serine carboxypeptidase protein family Carboxypeptidase K10B2.3 K10B2.3 Member of the lectin protein family lectin K10B2.4 K10B2.4 Protein of unknown function, has high similarity to uncharacterized human PTD008 K10B2.5 K10B2.5 Protein with similarity over the C-terminus to C. elegans Y49E10.S and D. melanogaster ANI (anillin) actin-binding protein K10B3.1 K10B3.1 Protein of unknown function, has weak similarity to C. elegans C01F6.9 K10B3.10 spc-1;imo-1;K10B3.10 Putative spectrin, has strong similarity to human alpha-spectrins and apparently involved in embryonic elongation spectrin alpha chain K10B3.2 K10B3.2 Protein of unknown function, putative paralog of C. elegans F38A1.3 transposase K10B3.5 K10B3.5 Protein with weak similarity to C. elegans F32E4.8 gene product K10B3.6 K10B3.6 Protein of unknown function, putative paralog of C. elegans T05H10.7, has similarity to S. cerevisiae Ypl110p K10B3.7 gpd-3;K10B3.7 Glyceraldehyde-3-phosphate dehydrogenase gpd-3 encodes a predicted glyceraldehyde 3-phosphate dehydrogenase that affects embryonic viability; GPD-3 interacts with LIN-2 in two-hybrid assays. K10B3.8 gpd-2;K10B3.8 Glyceraldehyde-3-phosphate dehydrogenase gpd-2 encodes one of four C. elegans glyceraldehyde-3-phosphate dehydrogenases (GAPDHs); by homology, GPD-2 is predicted to reversibly catalyze the oxidation and phosphorylation of glyceraldehyde-3-phosphate to 1,3-diphosphoglycerate during glycolysis; in C. elegans, GPD-2 and GPD-3 constitute the major GAPDH isoenzymes and are expressed at highest levels during postembryonic development, primarily in the actin-containing A and I zones of body-wall muscle; loss of gpd-2 function via RNA-mediated interference (RNAi) does not result in any abnormalities. K10B3.9 mai-1;K10B3.9 Protein of unknown function, has weak similarity to C. elegans B0546.1 and mitochondrial ATPase inhibitors mai-1 encodes a protein with similarity to human mitochondrial ATPase inhibitor; exists as the upstream gene in an operon with gpd-2 and gpd-3. K10B4.1 K10B4.1 Member of the animal heme peroxidase family, which catalyze biosynthetic and degradative reactions using hydrogen peroxide as the electron acceptor, has a region of low similarity to a region of human D2S448, which is a melanoma associated gene product peroxidase K10B4.2 K10B4.2 Protein containing a DUF32 domain of unknown function, has moderate similarity to uncharacterized C. elegans W01D2.4 7TM chemoreceptor, srt family K10B4.3 K10B4.3 Protein of unknown function K10B4.4 K10B4.4 Member of the rhodopsin family of G protein-coupled receptors (GPCR), has low similarity to neuromedin U receptor 2 (human NMU2R), which increases levels of intracellular calcium and may play a role in sensory transmission or modulation and feeding seven trans-membrane receptor K10B4.5 K10B4.5 Member of the 7-transmembrane chemoreceptor family of G protein-coupled receptors (GPCR), has high similarity to uncharacterized C. elegans SRD-1 7TM chemoreceptor, srd family K10B4.6 wnt-1;cwn-1;Ce-wnt-1;K10B4.6 Wnt family member cwn-1 is orthologous to the human gene SIGNALING PROTEIN WNT-4 (WNT4; OMIM:603490), which when mutated leads to disease. K10C2.1 K10C2.1 Putative serine carboxypeptidase, has strong similarity to human PPGB, protective protein for beta-galactosidase serine carboxypeptidase K10C2.2 K10C2.2 Protein of unknown function K10C2.3 K10C2.3 Putative aspartyl protease, has similarity to human renin (REN) and pepsinogen C (PGC) aspartyl protease K10C2.4 K10C2.4 Protein with high similarity to fumarylacetoacetate hydrolase (human FAH), which is involved in tyrosine catabolism and associated with type 1 hereditary tyrosinemia, member of the fumarylacetoacetate (FAA) hydrolase family fumarylacetoacetase; K10C2.4 is orthologous to the human gene FUMARYLACETOACETATE (FAH; OMIM:276700), which when mutated leads to disease. K10C2.5 K10C2.5 Protein of unknown function containing a Ground-like domain, has moderate similarity to C. elegans F42C5.7 K10C2.6 K10C2.6 Protein of unknown function K10C2.7 K10C2.7 Protein of unknown function K10C3.2 K10C3.2 Protein with weak similarity to H. sapiens Hs.199114 (Homo sapiens mRNA for ARPP-19 protein) cAMP-regulated phosphoprotein K10C3.3 zig-1;K10C3.3 Protein containing four immunoglobulin (Ig) domains, which may be involved in protein-protein and protein-ligand interactions IG superfamily repeats (I-type) K10C3.4 K10C3.4 Protein of unknown function K10C3.5 K10C3.5 Protein containing an elongation factor Tu GTP binding domain, an elongation factor G C-terminal domain, and an elongation factor Tu domain 2, has low similarity to S. cerevisiae Ria1p, which is a GTPase required for maturation of 60S ribosomal subunits elongation factor EF-2 like K10C3.6 nhr-49;K10C3.6 Member of the nuclear hormone receptor/Zinc finger protein family Ligand-binding domain of nuclear hormone receptors, Zinc finger, C4 type (two domains) K10C8.1 K10C8.1 Protein of unknown function, has low similarity to a region of poly(A)-specific ribonuclease (deadenylation nuclease, human PARN), which is a 3'-5' exoribonuclease that degrades mRNA poly(A) tails during oocyte maturation and in mRNA decay K10C8.2 K10C8.2 Protein of unknown function, has weak similarity to uncharacterized C. elegans T19F4.1, which is a putative G-protein coupled receptor (GPCR) G-protein coupled receptor; K10C8.2 encodes a homolog of the functionally active Fmrf Receptor (FR; CG2114) of D. melanogaster; it is thus possible that K10C8.2 is a receptor for one of the FMRF-like neurotransmitters in C. elegans (e.g., FLP-1 through FLP-12). K10C8.3 K10C8.3 Protein of unknown function, has a region of low similarity to S. cerevisiae Ist1p, which has a role in resistance to high concentrations of sodium Human KIIAA0174 protein like K10C9.1 K10C9.1 Protein of unknown function K10C9.2 K10C9.2 Member of the ribonuclease T2 (RNase T2) family, which cleave RNA to produce 2',3'-cyclic nucleotide products K10C9.3 K10C9.3 Member of the ribonuclease T2 (RNase T2) family, which cleave RNA to produce 2',3'-cyclic nucleotide products, has low similarity to uncharacterized ribonuclease 6 precursor (human RNASE6PL), which may be involved in negative regulation of proliferation ribonuclease K10C9.4 K10C9.4 Protein of unknown function, has weak similarity to C. elegans F44G3.11 K10C9.6 K10C9.6 Member of the 7-transmembrane chemoreceptor family of G protein-coupled receptors (GPCR), has weak similarity to C. elegans ODR-10, which is involved in odorant response 7TM chemoreceptor, str family K10C9.7 K10C9.7 Protein with strong similarity to C. elegans Y39A1A.18 gene product K10C9.8 K10C9.8 Member of the 7-transmembrane chemoreceptor family of G protein-coupled receptors (GPCR), has low similarity to C. elegans ODR-10, which is involved in odorant response 7TM chemoreceptor, str family K10D11.1 K10D11.1 Member of an uncharacterized protein family K10D11.2 K10D11.2 Member of an uncharacterized protein family K10D11.3 K10D11.3 Member of an uncharacterized protein family K10D11.4 K10D11.4 Protein of unknown function, has low similarity to uncharacterized C. elegans K10D11.6 K10D11.5 K10D11.5 Member of an uncharacterized protein family K10D11.6 K10D11.6 Protein containing a DUF141 domain of unknown function, has high similarity to uncharacterized C. elegans K10D11.3 K10D2.1 K10D2.1 Protein containing seven WD domains (WD-40 repeat) and seven leucine rich repeats, which mediate protein-protein interactions, has low similarity to histone cell cycle regulation defective homolog A (human HIRA), which is a transcriptional regulator K10D2.2 K10D2.2 Protein of unknown function, has a region of low similarity to a region of DNA polymerase kappa (S. pombe Cid1p), which is involved in caffeine sensitivity K10D2.3 K10D2.3 Protein containing a zinc knuckle domain, which can bind RNA or DNA in eukaryotes, has a region of low similarity to DNA polymerase kappa (S. pombe Cid1p), which is involved in caffeine sensitivity K10D2.4 K10D2.4 Protein of unknown function K10D2.5 K10D2.5 Protein of unknown function K10D2.6 K10D2.6 Member of the NADP-cytochrome P450 reductase (tentative) protein family NADPH-cytochrome P450 K10D2.7 K10D2.7 Protein of unknown function K10D3.1 glr-3;K10D3.1 Protein containing a ligand-gated ion channel domain, which are found in ionotropic glutamate receptors and NMDA receptors, has moderate similarity to kainate-selective ionotropic glutamate receptor 2 (human GRIK2), which functions in neurotransmission glutamate receptor; glr-3 encodes a protein that contains a ligand-gated ion channel domain and a receptor family ligand binding domain with similarity to kainate-selective ionotropic glutamate receptor 2 (human GRIK2); expressed in the RIA neuron. K10D3.2 unc-14;K10D3.2 Protein required for normal axon morphology The unc-14 gene encodes an activity required for both axonogenesis and sex myoblast migration. K10D3.3 taf-7.2;K10D3.3 Protein of unknown function, has a region of moderate similarity to TATA box binding protein (TBP)-associated factor RNA polymerase II I 28 (human TAF11), which forms a histone-like pair with TAF2K and coactivates transcription of some nuclear receptors transcription factor K10D3.4 K10D3.4 Member of the EGF-repeat protein family serine proteinase inhibitor (kunitz type) K10D3.5 K10D3.5 Protein containing two protein kinase domains K10D3.6 K10D3.6 Protein of unknown function K10D6.1 K10D6.1 Protein containing neurotransmitter-gated ion-channel ligand binding and transmembrane domains, has moderate similarity to C. elegans MOD-1, which is a serotonin-gated chloride channel GABA receptor beta subunit K10D6.2 K10D6.2 Putative ortholog of C. elegans C24H10.1 gene product K10D6.2 encodes three isoforms of a claudin homolog that may be required for normal cohesion of apical junctions in epithelia; K10D6.2A-C are worm-specific, with obvious homologs only in C. elegans; K10D6.2A-C are required for embryonic viability in mass RNAi assays; claudins are integral membrane proteins with four transmembrane sequences that are found in mammalian tight junctions (TJs), induce TJs when transgenically expressed in cells normally lacking them, and can mediate the specific conductance of of specific ions (e.g., magnesium or calcium) through TJs while blocking the flow of water. K10D6.3 K10D6.3 Protein of unknown function K10D6.4 K10D6.4 Protein of unknown function K10E9.1 K10E9.1 Protein of unknown function K10E9.2 K10E9.2 Protein of unknown function, has very strong similarity to uncharacterized C. elegans F30F8.4 transposase K10F12.2 K10F12.2 Protein of unknown function, has low similarity to a region of phospholipase C epsilon (rat LOC84587), which is stimulated by H-Ras (Hras) and mediates Ras-induced signal transduction by generating inositol triphosphate (IP3) second messenger K10F12.3 K10F12.3 Protein containing phosphatidylinositol-specific phospholipase C X and C Y domains and a C2 domain, has moderate similarity to phospholipase C epsilon (rat LOC84587), which is a phospholipase C that mediates ras-induced signal transduction phospholipase C K10F12.4 K10F12.4 Protein containing glutathione S-transferase N-terminal and C-terminal domains, has low similarity to glutathione-S-transferase like (human GSTTLP28), which has thiol transferase and dehydroascorbate reductase activity and modulates ryanodine receptors K10F12.5 rte-1;K10F12.5 Member of the reverse transcriptase protein family, which are RNA-dependent DNA polymerases, has very strong similarity to uncharacterized C. elegans F20B4.7 reverse transcriptase K10F12.6 K10F12.6 Protein of unknown function, has a region of moderate similarity to a region of C. elegans MES-1, which is required for asymmetric divisions of the germline in early embryos K10G4.1 K10G4.1 Protein containing two DUF38 domains of unknown function and an F-box domain, which serve as a link between a target protein and a ubiquitin-conjugating enzyme, has weak similarity to uncharacterized C. elegans T06E6.5 K10G4.2 K10G4.2 Protein of unknown function, has high similarity to uncharacterized C. elegans F14F8.6 7TM chemoreceptor, srw family K10G4.3 K10G4.3 Protein of unknown function, has moderate similarity to C. elegans Y32B12C.1 K10G4.4 K10G4.4 Protein containing a DUF38 domain of unknown function K10G4.5 K10G4.5 Protein containing two DUF38 domains of unknown function and an F-box domain, which serve as a link between a target protein and a ubiquitin-conjugating enzyme K10G4.6 K10G4.6 Member of the 7-transmembrane chemoreceptor family of G protein-coupled receptors (GPCR), has strong similarity to uncharacterized C. elegans K03D7.6 K10G4.7 K10G4.7 Member of the 7-transmembrane chemoreceptor family of G protein-coupled receptors (GPCR), has strong similarity to uncharacterized C. elegans K03D7.4 K10G6.1 lin-31;K10G6.1 HNF-3/forkhead transcription factor required for both inhibition and promotion of vulval cell fates lin-31 encodes a winged helix (WH)-like transcription factor that is a member of the HNF3/Forkhead family of DNA-binding proteins; LIN-31 acts as a tissue-specific effector of MAP kinase-mediated signaling in the vulva; when MAP kinase is inactive, LIN-31 forms a complex with LIN-1/Ets that inhibits vulval cell fates; upon MAP kinase activation (vulval induction), LIN-31 becomes phosphorylated, dissociates from LIN-1, and goes on to promote primary and secondary vulval cell fates; LIN-31 is expressed in the vulval precursor cells. K10G6.2 K10G6.2 Protein of unknown function K10G6.3 K10G6.3 Protein containing nine C2H2 type zinc finger domains, which bind nucleic acids sea-2 is an autosomal signal element gene, whose protein product contains four C2H2 zinc finger domains and three involucrin repeats embedded in extensive regions of low-complexity (e.g., glutamine/asparagine-rich) protein sequence; sea-2 has no obvious biological function in mass RNAi assays. K10G6.4 K10G6.4 Putative coiled-coil protein, has weak similarity to S. cerevisiae Uso1p, required for protein transport from ER to Golgi K10G9.1 K10G9.1 Protein with high similarity to C. elegans EAT-4, which is a putative Na+:Pi-cotransporter that is involved in muscle contraction, synaptic transmission, chemotaxis and mechanosensory perception sodium/phosphate transporter protein K10G9.2 K10G9.2 Protein of unknown function K10H10.1 K10H10.1 Member of the sugar (and other) transporter family, has weak similarity to human SLC17A7, which is a brain-specific Na+-dependent inorganic phosphate cotransporter that localizes exclusively to neuron-rich regions Sugar (and other) transporters K10H10.2 K10H10.2 Member of the pyridoxal phosphate dependent enzyme beta family, has moderate similarity to a region of cystathionine beta-synthase (L-serine hydrolyase (adding homocysteine), human CBS), which generates cystathionine from serine and homocysteine beta-synthase; This gene encodes a protein predicted by Eisenberg and coworkers, with 68% accuracy, to be mitochondrial. K10H10.3 K10H10.3 Member of an uncharacterized protein family Alcohol/other dehydrogenases, short chain type K10H10.4 K10H10.4 Protein of unknown function K10H10.5 K10H10.5 Protein of unknown function K10H10.6 K10H10.6 Protein with similarity to alcohol dehydrogenases, putative paralog of C. elegans K10H10.3 Alcohol/other dehydrogenases, short chain type K10H10.7 K10H10.7 Protein of unknown function, has high similarity to uncharacterized C. elegans ZK945.8 K10H10.9 K10H10.9 Protein of unknown function K11B4.1 K11B4.1 Possible small ribosomal subunit protein K11B4.2 K11B4.2 Protein of unknown function K11C4.1 K11C4.1 Serine/threonine protein kinase of the casein kinase I subfamily, has similarity to S. cerevisiae Hrr25p casein kinase I serine/threonine-protein kinase K11C4.2 K11C4.2 Member of the uncharacterized protein family (Hly-III or UPF0073), which may be hemolysins K11C4.3 unc-70;bgs-1;K11C4.3 Putative spectrin, has strong similarity to human, D. melanogaster and C. elegans spectrin proteins and necessary for the maintenance of organized muscle structure and normal neurite outgrowth spectrin beta chain; unc-70 encodes two isoforms of a beta-spectrin ortholog required for normal body curvature and shape, normal movement, and correct localization of the alpha-spectrin SPC-1; the predominant UNC-70 isoform is expressed in all embryonic cells except the intestine, at the plasma membrane at sites of intercellular contact; UNC-70 becomes largely restricted to muscles and neurons from hatching to adulthood, with expression in adult spermetheca and hypodermis as well; conversely, the minor isoform is predominantly expressed in gut, and is also apposed to intercellular membrane junctions in embryos; sma-1 mutations (which impair the one beta-H-spectrin ortholog in C. elegans) enhance the unc-70 phenotype; UNC-70 is dispensable for viability (under undemanding laboratory culture conditions). K11C4.4 odc-1;K11C4.4 Ornithine decarboxylase ornithine decarboxylase; odc-1 encodes ornithine decarboxylase, the first enzyme of polyamine biosynthesis that catalyzes the conversion of ornithine to putrescine; ODC-1 is required for development when animals are deprived of exogenous polyamines, which are required for oogenesis and completion of embryogenesis; in addition,ODC-1 may contribute to male fertility; ODC-1 activity is detectable at all developmental stages, with highest levels observed in adults and L4 larvae. K11C4.5 unc-68;ryr-1;kra-1;K11C4.5 Ryanodine receptor calcium channel ryanodine receptor; unc-68 encodes a ryanodine receptor ortholog that is expressed in body-wall muscle cells and is required for normal body tension and locomotion; unc-68 mutants are flaccid, sluggish, and resistant to ryanodine, but have normal muscle ultrastructure; UNC-68 is dispensable for excitation-contraction coupling itself, but may amplify its calcium signals; the unc-68/kra-1(kh30) mutation is an S1444N substitution at a putative protein kinase C phosphorylation site; UNC-68 reduced unc-103(sy557)-induced spicule protraction by one half; unc-68 is orthologous to the human genes RYR1 (OMIM:180901, mutated in malignant hyperthermia and central core disease), RYR2 (OMIM:180902, mutated in stress-induced polymorphic ventricular tachycardia), and RYR3 (OMIM:180903). K11D12.1 K11D12.1 Protein containing two C2H2 type zinc finger domains, which bind nucleic acids cwp-4 encodes a protein with some similarity to mucins that is predicted to be secreted, and is alleged to be coexpressed with polycystins; CWP-4 is dispensable for viability and gross morphology in mass RNAi screens. K11D12.10 K11D12.10 Protein containing a Src homology 3 (SH3) domain, which bind proline-rich peptides, and a protein kinase domain, has a region of low similarity to a region of human MAP3K9, which is an apoptosis activator involved in the JNK cascade K11D12.11 K11D12.11 Protein with strong similarity to C. elegans K11D12.7 gene product K11D12.2 K11D12.2 Protein with low similarity to human GTF2A1, which comprises the alpha and beta subunits of RNA polymerase II transcription factor II that are involved in transcriptional activation through interactions with TBP and the TFIID complex The protein product of this gene is predicted to contain a glutamine/asparagine (Q/N)-rich ('prion') domain, by the algorithm of Michelitsch and Weissman (as of the WS77 release of WormBase, i.e., in wormpep77). K11D12.3 K11D12.3 Protein of unknown function, has moderate similarity to uncharacterized C. elegans C13D9.1 K11D12.4 K11D12.4 Member of the choline or carnitine o-acyltransferase family, has low similarity to carnitine palmitoyltransferase I (rat Cpt1a), which acts in long-chain fatty acid beta-oxidation and influences energy production, cell signaling and apoptosis acetyltransferase K11D12.5 K11D12.5 Member of the MtN3-saliva family, which contain a region of two transmembrane helices, has high similarity to uncharacterized C. elegans R10D12.9 K11D12.6 K11D12.6 Member of an uncharacterized protein family K11D12.7 K11D12.7 Member of an uncharacterized protein family K11D12.8 K11D12.8 Protein of unknown function K11D12.9 K11D12.9 Protein containing N-terminal coiled-coil structure and a C-terminal C3HC4-type (RING finger) zinc finger domain zinc finger protein K11D2.1 K11D2.1 Protein containing two regulator of chromosome condensation (RCC1) repeat domains Human P619 protein like K11D2.2 K11D2.2 Member of the choloylglycine hydrolase family, which cleave carbon-nitrogen non-peptide bonds in linear amides, has moderate similarity to acid ceramidase (N-acylsphingosine amidohydrolase, human ASAH), which catalyzes the hydrolysis of ceramide Human PHP32 protein like; K11D2.2 is orthologous to the human gene N-ACYLSPHINGOSINE AMIDOHYDROLASE (ASAH; OMIM:228000), which when mutated leads to Farber lipogranulomatosis. K11D2.3 unc-101;K11D2.3 Putative clathrin-associated protein that negatively regulates vulval differentiation clathrin coat assembly protein; unc-101 encodes an adaptin orthologous to the mu1-I subunit of adaptor protein complex 1 (AP-1) that is involved in motility, egg-laying, negative regulation of LET-23 / EGF-receptor signalling, and localization of the neuronal receptors ODR-10 and GLR-1; it is broadly expressed. K11D2.4 K11D2.4 Protein containing four C2H2 type zinc finger domains, which bind nucleic acids, has a region of high similarity to a region of transcription factor 17 (rat Kid1), which is a transcriptional repressor that is involved in postnatal kidney development Zinc finger, C2H2 type (3 domains) K11D9.1 K11D9.1;CelMCAK Putative kinesin; has strong similarity to human KIF2 heavy chain kinesin; localized to kinetochores kinesin, kinesin-13 (MCAK/KIF-2) family, isoform b; klp-7 encodes two isoforms of a kinesin, related to XKCM1/MCAK, that is required to pull mitotic spindles asymmetrically to the posterior, probably by means of their posterior spindle poles, at the end of anaphase during the first embryonic mitosis. K11D9.2 mca-4;ser-1;sca-1;K11D9.2 Member of the P-type ATPase, Ca2+-type subfamily protein family; highly similar to mammalian SERCAs (Sarco/Endoplasmic Reticulum Calcium ATPase) E1-E2 ATPases; The sca-1 gene encodes a sarco-endoplasmic reticulum Ca[2+] ATPase homolog that is required for development and muscle function; sca-1 is also a ortholog of human ATP2A1 (OMIM:108730), which when mutated leads to Darier-White disease (OMIM:124200). K11D9.3 K11D9.3 Member of the sugar (and other) transporter family, has low similarity to solute carrier family 22 member 7 (rat Slc22a7), which is a multispecific sodium-independent organic anion transporter that transports nucleoside analogs and some drugs Sugar (and other) transporter K11E4.1 K11E4.1 Protein of unknown function K11E4.2 K11E4.2 Protein containing a Src homology 2 (SH2) domain, which are regulatory modules of intracellular signaling Src homology domain 2 K11E4.3 K11E4.3 Protein of unknown function, has moderate similarity to H. sapiens PON3 gene product paraoxonase-3 The K11E4.3 gene encodes one of five paraoxonase-like proteins; it is homologous to the human PARAOXONASE 1 gene (PON1, OMIM:168820), which in some allelic forms is associated with susceptibility to coronary artery disease. K11E4.4 K11E4.4 Protein containing a RhoGEF (GTPase exchange factor) domain and a Src homology 3 (SH3) domain, has low similarity to pak3 binding protein (mouse Arhgef7), which is a putative GTPase exchange factor for Rho GTPases that recruits Pak to focal complexes Src homology domain 3 K11E4.5 nhr-71;K11E4.5 Protein containing a nuclear hormone receptor C4-type zinc finger domain and a nuclear hormone receptor ligand-binding domain, has weak similarity to C. elegans NHR-80, which is involved in embryogenesis and morphogenesis Zinc finger, C4 type (two domains) K11E8.1 unc-43;dec-8;K11E8.1 Calcium/calmodulin dependent serine/threonine kinase type II (CaMKII) Ca2+/calmodulin-dependent protein kinase; unc-43(gf) mutants (in which unc-43 is overexpressed) suppress the excess motoneuron branching, and thus the uncoordinated phenotype, induced by an unc-6deltaC transgene. K11G12.1 K11G12.1 Member of the astacin (M12A) family of metalloproteases, has a region of low similarity to a region of tolloid-like (mouse Tll), which is a putative metalloprotease that processes probiglycan and appears to facilitate collagen-elastin crosslinking K11G12.2 acr-2;K11G12.2 Putative subunit of nicotinic (non-alpha) acetylcholine receptor nicotinic acetylcholine receptor subunit; A homolog of a non-alpha type nicotinic acetylcholine receptor subunit that forms a functional channel when co-expressed with the unc-38 alpha subunit. K11G12.3 K11G12.3 Protein with high similarity to iron transporter protein (rat Slc11a2), which is essential for intestinal iron absorption and iron transport out of endosomes in the transferrin cycle, member of the natural resistance-associated macrophage protein family transport system membrane protein K11G12.4 K11G12.4 Protein with high similarity to iron transporter protein (rat Slc11a2), which is essential for intestinal iron absorption and iron transport out of endosomes in the transferrin cycle, member of the natural resistance-associated macrophage protein family transport system membrane protein K11G12.5 K11G12.5 Dicarboxylate carrier protein, member of the mitochondrial carrier (MCF) protein family mitochondrial 2-oxoglutartae K11G12.6 K11G12.6 Protein of unknown function, has strong similarity to human Hs.150540 gene product (hypothetical protein, chromosome 22q13 BAC) K11G12.7 acr-3;K11G12.7 Component of a levamisole-gated channel nicotinic acetylcholine receptor subunit; acr-3 encodes a non-alpha subunit of the nicotinic acetylcholine receptor (nAChR) superfamily; ACR-3 functions as a ligand-gated ion channel that likely mediates fast actions of acetylcholine at neuromuscular junctions and in the nervous system; when coexpressed with UNC-38, an nAChR alpha subunit, the resulting hetero-oligomer can form levamisole-gated channels; ACR-3 is a member of the UNC-29-like group of nAChR subunits. K11G9.1 K11G9.1 Member of the carboxylesterase protein family esterase K11G9.2 K11G9.2 Member of the carboxylesterase protein family esterase K11G9.3 K11G9.3 Member of the carboxylesterase protein family esterase K11G9.4 egl-46;K11G9.4 C2H2-type zinc finger protein involved in neuronal development, has strong similarity to human INSM1, insulinoma-associated 1 zinc finger protein; egl-46 encodes a predicted transcription factor and conserved member of a TFIIA-like zinc finger protein family that affects coordinated locomotion, morphology and process formation of the touch cells, male mating efficiency, HSN cell migration, differentiation, and axonal outgrowth, serotonin production and also affects terminal divisions of the Q neuroblasts; acts to inhibit touch cell fate in FLP cells together with egl-44 and is expressed dynamically in neurons, specifically in touch cells, FLP, and HSN neurons. K11G9.5 K11G9.5 Member of the sugar (and other) transporter family, has weak similarity to solute carrier family 17 member 1 (mouse Slc17a1), which is involved in sodium-dependent phosphate transport and mediates hepatic and renal anion drug transport K11G9.6 mtl-1;CeMT-I;met-I;mt-I;K11G9.6 Protein of unknown function, has high similarity to uncharacterized C. elegans MTL-2, which is a likely metallothionein-related cadmium-binding protein mtl-1 encodes a metallothionein, a small, cysteine-rich, metal-binding protein; MTL-1 functions in metal detoxification and homeostasis and in stress adaptation; MTL-1 expression is induced in larval and adult intestinal cells following exposure to cadmium or heat stress, and in addition, is detected constitutively in three cells in the posterior pharyngeal bulb; MTL-1 intestinal expression is dependent upon ELT-2, an intestine-specific GATA-type transcription factor. K11H12.1 K11H12.1 Protein containing one BolA-like protein domain, which may be involved in controlling cell morphology, has high similarity to uncharacterized human LOC51027 DNA-binding protein; This gene encodes a protein predicted by Eisenberg and coworkers, with 52% accuracy, to be mitochondrial. K11H12.2 rpl-15;K11H12.2 Protein with high similarity to ribosomal protein L15 (S. cerevisiae Rpl15bp), which is a ribosomal structural protein, member of the ribosomal L15e family, which are part of the large ribosomal subunit 60S ribosomal protein L15; rpl-15 encodes a large ribosomal subunit L15 protein. K11H12.3 K11H12.3 Putative ortholog of C. elegans K11H12.4 gene product K11H12.4 K11H12.4 Member of an uncharacterized protein family; predicted to contain a glycosylphosphatidylinositol (GPI) lipid anchor K11H12.5 K11H12.5 Protein of unknown function K11H12.6 K11H12.6 Protein of unknown function, has high similarity to uncharacterized C. elegans K11H12.7 K11H12.7 K11H12.7 Protein of unknown function, has high similarity to uncharacterized C. elegans K11H12.6 K11H12.8 K11H12.8 Protein with weak similarity to H. sapiens TEGT (testis enhanced gene transcript) K11H12.9 K11H12.9 Putative serine/threonine protein kinase of the mitogen-activated protein kinase (MAP kinase) subfamily protein kinase K11H3.1 K11H3.1 Member of the glycerol-3-phosphate dehydrogenase, cytoplasmic protein family Glycerol-3-phosphate dehydrogenase K11H3.2 K11H3.2 Protein of unknown function K11H3.3 K11H3.3 Protein with high similarity to solute carrier family 25 member 1 (rat Slc25a1), which is a mitochondrial membrane citrate transporter, member of the mitochondrial carrier protein family of membrane transporters Mitochondrial carrier family K11H3.4 K11H3.4 Protein containing two GYF (glycine, tyrosine, phenylalanine) domains, which are proline-binding domains K11H3.5 K11H3.5 Protein of unknown function K12B6.1 K12B6.1 Protein containing a piwi domain and a PAZ (Piwi, Argonaut and Zwille) domain, which may mediate protein-protein interactions, has a region of weak similarity to a region of C. elegans ALG-1, which plays a role in LIN-4 stRNA production K12B6.2 K12B6.2 Protein of unknown function K12B6.3 K12B6.3 Member of the class 2 lipase family, has high similarity to uncharacterized C. elegans T01C3.4 K12B6.4 K12B6.4 Protein of unknown function K12B6.5 K12B6.5 Protein with weak similarity to C. elegans srd-1 (G protein-coupled receptor, expressed in chemosensory neurons, no homolog found in human or D. melanogaster) 7TM chemoreceptor, srn family K12B6.6 K12B6.6 Protein of unknown function K12B6.7 K12B6.7 Protein of unknown function, has weak similarity to C. elegans C24A3.1 K12B6.8 K12B6.8 Putative paralog of C. elegans F19B10.10 gene product K12C11.1 K12C11.1 Protein with high similarity to peptidase D (prolidase, human PEPD), which hydrolyzes dipeptides containing a C-terminal proline residue and functions in proline recycling during collagen synthesis, member of the metallopeptidase family M24 The K12C11.1 gene encodes an ortholog of the human gene PEPTIDASE D (PEPD), which when mutated leads to prolidase deficiency (OMIM:170100). K12C11.2 SMT3;K12C11.2 Ubiquitin-like protein K12C11.3 K12C11.3 Protein with strong similarity to C. elegans F58G6.2 gene product K12C11.4 K12C11.4 Protein containing seven ankyrin (Ank) repeats, a death domain, and a protein kinase domain, has low similarity to death associated protein kinase 1 (human DAPK1), which is a serine-threonine kinase that is a positive mediator of apoptosis ankyrin and protein kinase; tag-119/K12C11.4 encodes a death-associated protein (DAP) kinase homolog that may be involved in apoptosis. K12D12.1 K12D12.1 Protein with high similarity to DNA topoisomerase II alpha (mouse Top2a), member of the DNA gyrase or topoisomerase IV subunit A family and the ATP-dependent DNA topoisomerase II family, contains a histidine kinase-like ATPase domain DNA topoisomerase II; This gene encodes a protein predicted by Eisenberg and coworkers, with 52% accuracy, to be mitochondrial. K12D12.2 K12D12.2 Putative nuclear pore protein, with similarity to S. cerevisiae Nup192p and human p205 nuclear pore protein Hs.84790 npp-3 encodes a predicted nucleoporin that is a homolog of vertebrate Nup205, and is required for normal nuclear pore complex distribution in the nuclear envelope, affects nuclear exclusion of large non-nuclear macromolecules, chromatin condensation, early embryonic viability, body integrity and locomotion. K12D12.3 K12D12.3 Protein with high similarity to C. elegans SQT-1, which is a collagen, contains two collagen triple helix repeats, which are found in some extracellular proteins, and a nematode cuticle collagen N-terminal domain cuticle collagen K12D12.4 K12D12.4 Protein of unknown function K12D12.5 K12D12.5 Protein with similarity over a small region of the N-terminus to human ribonuclease H1 (RNASEH1) and C. elegans putative ribonuclease H (F59A6.6), has similarity over a small region of the C-terminus to D. melanogaster ribonuclease H1 (RNH1) K12D9.1 K12D9.1 Protein of unknown function, has high similarity to uncharacterized C. elegans R08F11.4 K12D9.10 K12D9.10 Protein of unknown function, has weak similarity to uncharacterized C. elegans ZK697.5, which is a putative G protein-coupled receptor 7TM chemoreceptor, srw family K12D9.11 K12D9.11 Putative ortholog of C. elegans K12D9.10 gene product K12D9.12 K12D9.12 Member of an uncharacterized protein family; predicted to contain a glycosylphosphatidylinositol (GPI) lipid anchor K12D9.3 K12D9.3 Protein of unknown function, has low similarity to uncharacterized C. elegans T05B4.6, which is a G protein-coupled receptor of unknown function 7TM chemoreceptor, srw family K12D9.4 K12D9.4 Protein of unknown function, has high similarity to uncharacterized C. elegans K12D9.5, which is a putative G protein-coupled receptor 7TM chemoreceptor, srw family K12D9.5 K12D9.5 Protein of unknown function, has strong similarity to uncharacterized C. elegans K12D9.7 7TM chemoreceptor, srw family K12D9.6 K12D9.6 Protein with similarity to members of the G protein-coupled receptor family, no homolog found in human or D. melanogaster K12D9.7 K12D9.7 Protein of unknown function, has strong similarity to uncharacterized C. elegans K12D9.5, which is a putative G protein-coupled receptor 7TM chemoreceptor, srw family K12D9.8 K12D9.8 Protein of unknown function, has high similarity to uncharacterized C. elegans K12D9.5, which is a putative G protein-coupled receptor K12D9.9 K12D9.9 Protein of unknown function, has moderate similarity to uncharacterized C. elegans T05B4.7, which is a putative G protein-coupled receptor 7TM chemoreceptor, srw family K12F2.1 myo-3;sup-3;mhc-a;Myosin;K12F2.1 Sarcomeric myosin heavy chain, minor component required for thick filaments in body-wall muscle myosin heavy chain; myo-3 encodes MHC A, the minor isoform of MHC (myosin heavy chain) that is essential for thick filament formation, and for viability, movement, and embryonic elongation; expressed in body muscle, the somatic sheath cell covering the hermaphrodite gonad, and also expressed in enteric muscle, vulval muscles of the hermaphrodite and the diagonal muscles of the male tail. K12F2.2 K12F2.2 Protein of unknown function, has very strong similarity to a region of C. elegans VAB-8, which is required for some cell migrations and growth cone outgrowth kinesin-like protein; The vab-8 gene encodes a novel protein containing an atypical kinesin-like motor domain that is required for many posteriorly-directed cell migrations, as well as axonal outgrowth and pathfinding; vab-8 encodes two protein isoforms: VAB-8S, a novel protein expressed in migrating cells, and VAB-8L, which contains a kinesin-related domain, is expressed in neurons and functions in growth cone migrations; VAB-8 interacts with UNC-51, a serine-threonine kinase also required for axon outgrowth. K12G11.1 K12G11.1 Member of the sulfate transporter family, contains a sulphate transporter and antisigma factor antagonist (STAS) domain, which may bind NTPs, has low similarity to diastrophic dysplasia sulfate transporter (solute carrier family 26 member 2, rat Slc26a2) sulphate transporter K12G11.2 K12G11.2 Member of the sulfate transporter family, contains a sulphate transporter and antisigma factor antagonist (STAS) domain, which may bind NTPs, has low similarity to diastrophic dysplasia sulfate transporter (solute carrier family 26 member, rat Slc26a2) sulphate transporter K12G11.3 K12G11.3 Protein with high similarity to C. albicans Adh1p, which is an alcohol dehydrogenase and may function as an extracellular matrix adhesin, member of the zinc-containing alcohol dehydrogenase family, which catalyze oxidation of ethanol to acetaldehyde alcohol dehydrogenase K12G11.4 K12G11.4 Member of the alcohol dehydrogenase protein family alcohol dehydrogenase K12G11.5 K12G11.5 Protein with weak similarity to members of the SRG subfamily of G protein-coupled receptors, has a short region of similarity to human amyloid beta precursor protein, which is involved in Alzheimer's disease 7TM receptor, srx family K12H4.1 ceh-26;K12H4.1 Protein with low similarity to prospero-related homeobox 1 (human PROX1), which is a transcription factor that may be involved in development of the lens ceh-26 encodes a protein that contains a prospero-related homeodomain; expressed in nuclei of the adult head, tail neurons, and one cell in the postdeirids. K12H4.2 K12H4.2 Protein containing a DUF143 domain of unknown function K12H4.3 K12H4.3 Putative ortholog of S. cerevisiae Yol077p, a protein of unknown function whose expression is downregulated by DNA damage K12H4.4 K12H4.4 Putative subunit of signal peptidase complex, has similarity to S. cerevisiae Spc3p Signal peptidase K12H4.5 K12H4.5 Protein of unknown function K12H4.6 K12H4.6 Protein of unknown function K12H4.7 K12H4.7 Member of the carboxypeptidase protein family K12H4.8 dcr-1;let-740;K12H4.8 Helicase and RNase; functions in the production of stRNAs (small temporal RNAs) and in RNA interference, probably via a role in the production of siRNAs, small interfering RNAs dead box helicase; The dcr-1 gene encodes a bidentate ribonuclease that is homologous to E. coli RNAse III; dcr-1 is required both for RNA interference and for synthesis of small developmental RNAs; DCR-1 interacts in vivo with RDE-4, a double-stranded RNA (dsRNA) binding protein required for RNAi that interacts with trigger dsRNAs and may function to deliver dsRNAs to DCR-1 for endonucleolytic processing. K12H6.1 K12H6.1 Protein containing two nuclear hormone receptor C4-type zinc finger domains and a nuclear hormone receptor ligand-binding domain, has low similarity to nuclear receptor subfamily 2 group F member 6 (human NR2F6), which is a transcriptional corepressor zinc finger protein K12H6.10 K12H6.10 Protein of unknown function K12H6.11 K12H6.11 Protein containing a SET domain, which are involved in protein-protein interactions, has low similarity to uncharacterized C. elegans C41G7.4 K12H6.12 K12H6.12 Protein containing three C2H2 type zinc finger domains, which bind nucleic acids K12H6.2 K12H6.2 Protein of unknown function K12H6.3 K12H6.3 Protein with low similarity to fucosyltransferase 7 (alpha 1,3 fucosyltransferase, mouse Fut7), which is involved in cell adhesion, P-selectin glycoprotein ligand-1 (Selpl) and other selectin ligand biosynthesis, and forms the sialyl Lewis x moiety fut-4 encodes a member of the glycosyltransferase 10 family. K12H6.4 K12H6.4 Protein of unknown function K12H6.5 K12H6.5 Protein of unknown function K12H6.6 K12H6.6 Protein of unknown function, has high similarity to uncharacterized C. elegans Y63D3A.8 K12H6.7 K12H6.7 Protein with moderate similarity to C. elegans F40G9.9 gene product K12H6.8 K12H6.8 Protein with moderate similarity to C. elegans K12H6.9 gene product K12H6.9 K12H6.9 Protein with moderate similarity to C. elegans K12H6.8 gene product LEV-11 tmy-1;lev-11 Tropomyosin LLC1.1 tra-3;LLC1.1 Atypical calpain regulatory protease required in hermaphrodites for soma and germ line development calpain (TRA-3) LLC1.2 LLC1.2 Protein of unknown function, has low similarity to uncharacterized C. elegans F19C7.1 LLC1.3 LLC1.3 Protein with high similarity to dihydrolipoamide dehydrogenase (human DLD), member of the pyridine nucleotide-disulphide oxidoreductase family, contains a pyridine nucleotide-disulphide oxidoreductase dimerization domain dihydrolipoamide dehydrogenase; LLC1.3 is orthologous to the human gene DIHYDROLIPOAMIDE DEHYDROGENASE (DLD; OMIM:246900), which when mutated leads to dihydrolipoamide dehydrogenase deficiency; LLC1.3 protein is predicted to be mitochondrial. M01A10.1 M01A10.1 Protein containing four KH domains, which may bind RNA, has low similarity to far upstream element binding protein 3 (human FUBP3), which is a single-strand DNA binding transcription factor that activates MYC gene expression via far-upstream element DNA-binding protein; M01A10.1 encodes a protein, belonging to an ancient family of single-stranded nucleic acid-binding proteins, that is predicted to regulate gene expression through binding either mRNA or (locally) single-stranded DNA; it is most likely to specifically bind one or more discrete mRNAs and regulate their spatial localization or alternative splicing. M01A10.2 M01A10.2 Protein containing six WD domains (WD-40 repeat), which may mediate protein-protein interactions, has low similarity to m-tomosyn (rat LOC81022), which is a SNARE binding protein that interacts with syntaxin 1a (rat Stx1a) M01A10.3 M01A10.3 Putative ribophorin, has strong similarity to human RPN2, ribophorin II M01A10.4 M01A10.4 Member of the reverse transcriptase protein family, which are RNA-dependent DNA polymerases, has strong similarity to uncharacterized C. elegans C49D10.1 M01A10.5 M01A10.5 Protein of unknown function M01A12.1 M01A12.1 Member of the protein-tyrosine phosphatase family, contains two collagen triple helix repeats, which are found in some extracellular proteins, has a region of high similarity to a region of procollagen type VI alpha 2 subunit (mouse Col6a2) collagen M01A12.2 M01A12.2 Protein of unknown function M01A8.1 M01A8.1 Protein of unknown function M01A8.2 M01A8.2 Protein containing one CAP-Gly domain, which is predicted to be in an alpha-helical coiled-coil conformation CAP-Gly domain M01B12.1 M01B12.1 Protein of unknown function, has moderate similarity to uncharacterized C. elegans K03F8.1 M01B12.2 M01B12.2 Protein of unknown function, has low similarity to a region of phosphatidylinositol glycan class N (mouse Pign), which transfers phosphoethanolamine to the first mannose of glycosylphosphatidylinositol anchors M01B12.3 M01B12.3 Protein of unknown function, has high similarity to uncharacterized C. elegans AR16 M01B12.4 M01B12.4 Protein with weak similarity to S. cerevisiae MNN4 (Protein required for transfer of mannosylphosphate to core and outer chain portions of N-linked oligosaccharides) M01B12.5 M01B12.5 Putative ortholog of S. cerevisiae Rio1p, an essential protein of unknown function M01B2.1 Cehd-5;M01B2.1 Putative receptor tyrosine protein kinase, has similarity to human and D. melanogaster fibroblast growth factor receptor-related protein kinases tyrosine-protein kinase (KIN15/KIN16 subfamily); kin-30 encodes a predicted tyrosine kinase; kin-30 is expressed during larval stages, but has not been detected in adults; the expression of kin-30 was experimentally verified by RT-PCR. M01B2.10 M01B2.10 Putative ortholog of C. elegans Y92H12BR.7 gene product M01B2.2 M01B2.2 Protein of unknown function, has very strong similarity to uncharacterized C. elegans T26E4.12 M01B2.3 M01B2.3 Protein containing a DUF40 domain of unknown function, which contain four conserved cysteines, has high similarity to uncharacterized C. elegans M01B2.4 7TM receptor, srbc family M01B2.4 M01B2.4 Protein containing a DUF40 domain of unknown function, which contain four conserved cysteines, has strong similarity to uncharacterized C. elegans T26E4.13 7TM receptor, srbc family M01B2.5 M01B2.5 Protein of unknown function, has high similarity to uncharacterized C. elegans F40D4.8 M01B2.6 M01B2.6 Member of the glycosyl hydrolase 18 family, has a region of low similarity to chitinase 3-like 1 (cartilage glycoprotein-39, human CHI3L1), which binds chitin but lacks chitinase activity, and is associated with rheumatoid arthritis cartilage Glycosyl hydrolases family 18 M01B2.7 M01B2.7 Member of the rhodopsin family of G protein-coupled receptors (GPCR), has strong similarity to uncharacterized C. elegans T26E4.15 7 transmembrane receptor (rhodopsin family) M01B2.8 M01B2.8 Protein of unknown function, has strong similarity to uncharacterized C. elegans F54B8.1 M01B2.9 M01B2.9 Protein of unknown function, has strong similarity to uncharacterized C. elegans T26E4.14 7 transmembrane receptor (rhodopsin family) M01D1.1 M01D1.1 Member of the 7-transmembrane chemoreceptor family of G protein-coupled receptors (GPCR), has low similarity to C. elegans ODR-10, which is a G protein-coupled receptor involved in odorant response 7TM chemoreceptor, str family M01D1.10 M01D1.10 Putative ortholog of C. elegans K05F6.9 gene product M01D1.2 M01D1.2 Protein containing two meprin and TRAF homology (MATH) domains M01D1.3 M01D1.3 Protein containing one BTB (BR-C, ttk and babor) or POZ (Pox virus and zinc finger) domain, which are found in some DNA and actin binding proteins and may mediate protein-protein interactions, has strong similarity to uncharacterized C. elegans K02E7.9 M01D1.4 M01D1.4 Member of the transposase family, which are required for excising and inserting mobile genetic elements, has very strong similarity to uncharacterized C. elegans F27B3.4 transposase M01D1.5 M01D1.5 Protein containing 23 GLTT repeat region domains M01D1.6 M01D1.6 Protein containing 17 GLTT repeat region domains M01D1.7 M01D1.7 Protein containing an F-box domain, which serve as a link between a target protein and a ubiquitin-conjugating enzyme, has moderate similarity to uncharacterized C. elegans K05F6.9 This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins; its encoded protein also contains a Pfam-B45 motif of presently unknown function. M01D1.8 M01D1.8 Protein containing an F-box domain, which serve as a link between a target protein and a ubiquitin-conjugating enzyme, has moderate similarity to uncharacterized C. elegans M01D1.10 This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins; its encoded protein also contains a Pfam-B45 motif of presently unknown function. M01D1.9 M01D1.9 Protein containing an F-box domain, which serve as a link between a target protein and a ubiquitin-conjugating enzyme, has moderate similarity to uncharacterized C. elegans M01D1.10 This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins; its encoded protein also contains a Pfam-B45 motif of presently unknown function. M01D7.1 M01D7.1 Protein containing an F-box domain, which serve as a link between a target protein and a ubiquitin-conjugating enzyme, has high similarity to uncharacterized C. elegans Y39A1A.16 This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins; its encoded protein also contains a Pfam-B45 motif of presently unknown function. M01D7.2 scamp;M01D7.2 Protein of unknown function, has moderate similarity to uncharacterized secretory carrier membrane protein 3 (mouse Scamp3) M01D7.3 M01D7.3 Protein with moderate similarity to C. elegans C54G7.4 gene product M01D7.4 M01D7.4 Protein containing a GHMP (galactose-homoserine-mevalonate-phosphomevalonate) kinase ATP-binding domain, has moderate similarity to galactokinase 2 (human GALK2), which may phosphorylate N-acetylgalactosamine during UDP-N-acetylgalactosamine biosynthesis galactokinase M01D7.5 M01D7.5 LQFamide neurotransmitter nlp-12 encodes two predicted neuropeptide-like proteins; nlp-12 is part of a LQFamide neuropeptide family that has members in at least one other nematode species; nlp-12 is expressed in one tail neuron; as loss of nlp-12 activity via large-scale RNAi screens does not result in any obvious abnormalities, the precise role of nlp-12-encoded peptides in development and/or behavior is not yet known. M01D7.6 emr-1;Ce-Emerin;M01D7.6 Integral membrane protein with a LEM (LAP2-emerin-MAN1) domain, it has similarity to emerin emr-1 gene encodes a homolog of the human integral nuclear membrane protein emerin (EMD, OMIM:300384, mutated in X-linked Emery-Dreifuss muscular dystrophy); EMR-1 belongs to a family of proteins sharing the LEM-domain that are generally conserved in metazoa; EMR-1 protein is found in the nuclear envelopes of all cell types except sperm, in embryos, larvae, and adults; EMR-1 binds the lamin LMN-1, and functionally overlaps with LEM-2 with respect to chromosome segregation and cell division. M01D7.7 egl-30;gqa-1;M01D7.7 Guanine nucleotide-binding protein alpha subunit involved in regulation of muscle contraction guanine nucleotide-binding protein; The egl-30 gene encodes an ortholog of the heterotrimeric G protein alpha subunit Gq (Gq/G11 class) that affects viability, locomotion, egg laying, synaptic transmission, and pharyngeal pumping; it genetically interacts with the goa-1 pathway, and is probably expressed ubiquitously, with highest expression in excitable cells. M01E10.2 M01E10.2 Protein containing a von Willebrand factor (vWF) type A domain, has a region of low similarity to a region of cuticulin component (C. elegans CUT-1) M01E10.3 M01E10.3 Protein with strong similarity to C. elegans Y39A3A.2 gene product M01E11.1 M01E11.1 Protein with moderate similarity to farnesyl cysteine carboxyl methyltransferase (S. pombe Mam4p), which is required for the production of mature M-factor mating pheromone M01E11.2 M01E11.2 Protein of unknown function, has low similarity to uncharacterized S. pombe Spac1952.06cp M01E11.3 M01E11.3 Protein of unknown function, has weak similarity to C. elegans T07C12.3 M01E11.4 M01E11.4 Protein of unknown function M01E11.5 M01E11.5 Protein containing a cold-shock nucleic acid binding domain, which bind both single-stranded DNA and single-stranded RNA, has a region of moderate similarity to a region of Y-box binding protein 1 (mouse Nsep1), which binds single stranded DNA and RNA cey-3 encodes a protein with a cold-shock/Y-box domain; it is predicted to be mitochondrial by phylogenetic profiling. M01E11.6 klp-15;CeKLP-15;M01E11.6 C-terminal motor Kinesin kinesins M01E11.7 M01E11.7 Protein containing a Src homology 2 (SH2) domain, which are regulatory modules of intracellular signaling, has a region of high similarity to a region of tensin (mouse Tns), which is involved in myoblast fusion and is required for kidney development tensin M01E5.1 M01E5.1 Protein of unknown function M01E5.2 M01E5.2 Member of the GTP1 or OBG family of GTP-binding proteins, has a region of low similarity to a region of developmentally regulated GTP-binding protein 1 (human DRG1), which is a putative GTP-binding protein that binds the transcription factor human TAL1 GTP-binding protein M01E5.3 M01E5.3 Protein of unknown function M01E5.4 M01E5.4 Protein of unknown function M01E5.5 topoI;M01E5.5 DNA topoisomerase I, predicted to relax supercoiled DNA by making single-stranded breaks DNA topoisomerase I M01E5.6 M01E5.6 Protein containing a KIX domain, which bind transcription factor transactivation domains, has a region of low similarity to a region of C. elegans CBP-1, which is a transcriptional activator that may be involved in cell differentiation M01F1.1 gly-14;M01F1.1 UDP-N-acetylglucosamine:alpha-3-D-mannoside beta-1,2-N-acetyl-glucosaminyltransferase I alpha-1,3-mannosyl-glycoprotein beta-1,2-N-acetylglucosaminyltransferase M01F1.2 M01F1.2 Protein with high similarity to ribosomal protein L13A (mouse Rpl13a), which is a putative component of the large 60S ribosomal subunit that may act as a tissue-specific transplantation antigen, member of the ribosomal L13 family L13P family ribosomal protein; rpl-16 encodes a large ribosomal subunit L13a protein. M01F1.3 M01F1.3 Putative ortholog of S. cerevisiae Lip5p, a lipoic acid synthase lipoic acid synthase; This gene encodes a protein predicted by Eisenberg and coworkers, with 68% accuracy, to be mitochondrial. M01F1.4 M01F1.4 Protein has similarity to human CG2 gene identified in the Familial dysautonomia candidate region on 9q31 M01F1.5 M01F1.5 Member of the sugar (and other) transporter family, has low similarity to S. pombe Itr2p, which is an essential myo-inositol transporter glucose transport protein M01F1.6 M01F1.6 Possible large ribosomal subunit protein M01F1.7 M01F1.7 Member of the phosphatidylinositol transfer protein family, which are involved in phospholipid intracellular transport, contains a DDHD domain, has moderate similarity to retinal degeneration B2 (mouse Rdgb2), which may play a role in phototransduction RETINAL DEGENERATION B PROTEIN (PROBABLE CALCIUM TRANSPORTER RDGB); M01F1.7 encodes a phosphatidylinositol transfer protein, with a C-terminal DDHD domain, that is orthologous to RETINAL DEGENERATION B (RDGB) in D. melanogaster, as well as other orthologs in mammals (NIR1-3); M01F1.7 is expressed in the egg membrane, the germline, the spermatheca and three pairs of head neurons; while M01F1.7 would be expected to mediate PIP(2) signalling in either neuronal function or cytokinesis, it has not yet had a published mutant phenotype, and has no obvious function in mass RNAi assays. M01F1.8 M01F1.8 Protein of unknown function M01G12.1 M01G12.1 Member of the 7-transmembrane chemoreceptor family of G-protein coupled receptors (GPCR), has very strong similarity to uncharacterized C. elegans M01G12.13 7TM chemoreceptor, sri family M01G12.10 M01G12.10 Protein of unknown function M01G12.11 M01G12.11 Protein with strong similarity to C. elegans M01G12.3 gene product M01G12.12 rrf-2;M01G12.12 Protein with high similarity to C. elegans EGO-1, which is necessary for germ-line development rrf-2 encodes an RNA-directed RNA polymerase (RdRP) homolog of unknown function; RRF-2 is not obviously required for either somatic or germline RNAi, or for transitive RNAi. M01G12.13 M01G12.13 Member of the 7-transmembrane chemoreceptor family of G protein-coupled receptors (GPCR), has very strong similarity to uncharacterized C. elegans M01G12.1 7TM chemoreceptor, sri family M01G12.14 M01G12.14 Protein of unknown function, has moderate similarity to uncharacterized C. elegans Y47H10A.4 M01G12.2 M01G12.2 Protein of unknown function, has high similarity to uncharacterized C. elegans M01G12.5 M01G12.3 M01G12.3 Protein containing a DUF32 domain of unknown function, has high similarity to uncharacterized C. elegans F47D2.1 M01G12.4 M01G12.4 Protein of unknown function, has moderate similarity to uncharacterized C. elegans ZK1037.9 7TM chemoreceptor, srw family M01G12.5 M01G12.5 Protein of unknown function, has high similarity to uncharacterized C. elegans M01G12.2 M01G12.6 M01G12.6 Protein of unknown function, has weak similarity to uncharacterized C. elegans T03E6.6 M01G12.7 M01G12.7 Protein of unknown function, has moderate similarity to uncharacterized C. elegans M01G12.14 M01G12.9 M01G12.9 Protein of unknown function, has moderate similarity to uncharacterized C. elegans Y47H10A.4 M01G4.1 M01G4.1 Protein of unknown function M01G5.1 M01G5.1 Protein of unknown function M01G5.3 M01G5.3 Protein of unknown function, has moderate similarity to uncharacterized human TMPIT M01G5.4 M01G5.4 Protein with strong similarity to C. elegans M01G5.3 gene product M01G5.5 M01G5.5 Member of the sodium:neurotransmitter symporter family, has low similarity to solute carrier family 6 member 5 (human SLC6A5), which is a sodium and chloride-dependent glycine transporter that may function in synaptic transmission sodium-dependent transporter; snf-6 encodes a member of the sodium:neurotransmitter symporter family. M01H9.1 M01H9.1 Member of the thioredoxin family, which are small enzymes involved in redox reactions, has moderate similarity to C. elegans R05H5.3, which is a putative nuclear thioredoxin M01H9.2 M01H9.2 Protein of unknown function, has weak similarity to C. elegans F01D5.1 M01H9.3 M01H9.3 Protein of unknown function M01H9.4 M01H9.4 Protein of unknown function M02A10.1 M02A10.1 Protein of unknown function M02A10.2 irk-2;M02A10.2 Member of the 2 TM potassium channel protein family potassium channel; irk-2 encodes an inwardly rectifying potassium channel based on sequence homology to the the human potassium channel genes KCNJ1/KCNJ2. M02A10.3 sli-1;M02A10.3 Putative negative regulator of let-23 and/or other genes of the vulval induction pathway adaptor-like E3 ubiquitin ligase M02B1.1 M02B1.1 Protein with low similarity to solute carrier family 35 member 3 (UDP-N-acetylglucosamine(UDP-GlcNAc) transporter, human SLC35A3), which transports nucleotide sugars CMP-sialic acid transporter M02B1.2 M02B1.2 Protein of unknown function M02B1.3 M02B1.3 Protein of unknown function, has moderate similarity to uncharacterized C. elegans F41H10.5 M02B1.4 M02B1.4 Protein of unknown function M02B7.1 M02B7.1 Protein of unknown function, has high similarity to uncharacterized C. elegans Y54G2A.22 M02B7.2 M02B7.2 Member of the exonuclease family, has strong similarity to uncharacterized C. elegans R02D3.8 M02B7.3 osm-3;avr-5;caf-1;klp-2;M02B7.3 Kinesin-related motor protein required for normal chemotaxis and dauer formation kinesin; osm-3 encodes a homolog of the heavy chain subunit of heteromeric anterograde motor kinesins; OSM-3 is required for formation of the distal segment of amphid channel cilia, for responses to osmotic stimuli, for normal dauer formation, and for sensitivity to caffeine. M02B7.4 M02B7.4 Protein of unknown function M02B7.5 M02B7.5 Protein containing a Sec7 domain, which are guanine nucleotide exchange factors for ARF family GTPases, and an IQ calmodulin-binding domain, has a region of moderate similarity to a region of pleckstrin homology Sec7 and coiled coil domains 1 (rat Pscd1) This gene encodes a protein predicted by Eisenberg and coworkers, with 52% accuracy, to be mitochondrial. M02B7.6 M02B7.6 Protein with high similarity to calmodulin 1 (human CALM1), which regulates the calcium-dependent activity of proteins, enzymes and ion channels, contains four EF hand domains, which are found in signaling, buffering or transport proteins calmodulin-like protein; cal-3 encodes a member of the calmodulin family. M02D8.1 M02D8.1 Protein containing an immunoglobulin (Ig) domain, has low similarity to a region of C. elegans UNC-22, which is a serine-threonine protein kinase that may regulate contraction M02D8.2 M02D8.2 Protein of unknown function M02D8.3 M02D8.3 Protein with weak similarity to D. melanogaster eIF-4G (Eukaryotic-initiation-factor-4G) M02D8.4 M02D8.4 Protein with high similarity to asparagine synthetase (S. cerevisiae Asn1p), which acts in nitrogen metabolism, member of the asparagine synthase family, contains a glutamine amidotransferases class II (purF-type) domain asparagine synthase M02D8.5 M02D8.5 Protein of unknown function M02E1.1 M02E1.1 Protein of unknown function M02E1.2 M02E1.2 Protein of unknown function M02F4.1 M02F4.1 Protein of unknown function, has strong similarity to C. elegans R04D3.3 M02F4.2 M02F4.2 Putative paralog of C. elegans T15D6.12 M02F4.3 M02F4.3 Protein of unknown function, has moderate similarity to C. elegans C52D10.12 M02F4.3 encodes a homolog of human ACDP1-ACDP4 and a paralog of C01H6.6, C33D12.2, C52D10.12, R04E5.2, and R13G10.4; both M02F4.3 and ACDP1-ACDP4 belong to a family of proteins (defined by NCBI as KOG2118) that are predicted to be membrane-spanning and that share a motif (the 'ACD domain') with proteins from bacteria, yeast, plants, and metazoa; murine Acdp1 is a plasma membrane protein bacterial proteins containing the ACD domain include CorC from Salmonella typhimurium, which is involved in magnesium and cobalt efflux; M02F4.3 has no obvious function in RNAi assays. M02F4.7 M02F4.7 Protein with weak similarity to H. sapiens LY75 (lymphocyte antigen 75) M02F4.8 M02F4.8 Protein with strong similarity to C. elegans AQP (Protein with strong similarity to H. sapiens AQP3 (aquaporin 3)) MIP family protein M02F4.9 M02F4.9 Protein of unknown function, has moderate similarity to C. elegans M02F4.1 M02G9.1 M02G9.1 Protein containing 32 uncharacterized DUF139 cysteine repeat domains keratin like protein M02G9.2 M02G9.2 Protein containing six uncharacterized DUF139 cysteine repeat domains, has low similarity to uncharacterized C. elegans AC3.3 M02G9.3 M02G9.3 Protein containing ten uncharacterized DUF139 cysteine repeat domains, has low similarity to uncharacterized C. elegans F35A5.4 M02H5.1 nhr-99;M02H5.1 Member of the nuclear hormone receptor/Zinc finger protein family M02H5.10 M02H5.10 Putative ortholog of C. elegans M02H5.11 gene product 7TM chemoreceptor, srh family M02H5.11 M02H5.11 Putative ortholog of C. elegans M02H5.10 gene product 7TM chemoreceptor, srh family M02H5.12 M02H5.12 Putative ortholog of C. elegans F54B8.9 gene product M02H5.2 M02H5.2 Putative ortholog of C. elegans C24B9.6 gene product 7TM chemoreceptor, srt family M02H5.3 M02H5.3 Putative ortholog of C. elegans M02H5.5 gene product M02H5.4 M02H5.4 Putative ortholog of C. elegans M02H5.5 gene product M02H5.5 M02H5.5 Putative ortholog of C. elegans M02H5.4 gene product M02H5.7 M02H5.7 Putative ortholog of C. elegans nhr-98 gene product M02H5.8 M02H5.8 Protein with moderate similarity to C. elegans Y38H6C.1 gene product M02H5.9 M02H5.9 Putative ortholog of C. elegans srh-37 gene product 7TM chemoreceptor, srh family M02H5.D nhr-98;M02H5.6;M02H5.D Member of the nuclear hormone receptor/Zinc finger protein family M03A1.1 vab-1;M03A1.1 Putative receptor tyrosine protein kinase, is autophosphorylated and involved in directing epidermal morphogenesis by signaling from neuronal cells to hypodermal cells, has strong similarity to human and D. melanogaster eph-like receptor tyrosine kinases tyrosine-protein kinase receptor M03A1.3 dao-2;M03A1.3 Protein containing a DB module domain M03A1.3 encodes a protein with ~10 predicted transmembrane sequences; it has an internal repeat (in residues 74-351 and 377-668), with some similarity in these repeated domains to worm C05D12.1 and C13B4.1, and to mammalian stromal cell derived factor receptor 2. M03A1.6 M03A1.6 Protein containing a DDHD domain, which may bind metal, has weak similarity to human P125, which interacts with SEC23 vesicle trafficking proteins and may play a role in the early secretory pathway M03A8.1 M03A8.1;fat-2 Member of the SCP-2 sterol transfer family and of the short-chain dehydrogenase-reductase family, has weak similarity to C. elegans C17G10.8, which functions in lipid metabolism alcohol dehydrogenase; non-specific lipid transfer protein; dhs-28 encodes an ortholog of human 17-BETA-HYDROXYSTEROID DEHYDROGENASE 4 (HSD17B4; OMIM:601860, mutated in D-bifunctional protein deficiency), which contains a C-terminal SCP-2 sterol transfer domain; the deletion allele dhs-28(ok450) is superficially wild-type. M03A8.2 M03A8.2 Protein of unknown function, has weak similarity to uncharacterized human KIAA0404 M03A8.3 M03A8.3 Protein of unknown function M03A8.4 M03A8.4 Protein of unknown function M03A8.5 M03A8.5 Protein of unknown function M03B6.1 M03B6.1 Protein of unknown function M03B6.2 M03B6.2 Protein with weak similarity to solute carrier family 16 member 4 (human SLC16A4), which is a a proton-dependent lactate transport protein that is associated with mitochondrial myopathies upon overexpression monocarboxylate transporter like M03B6.3 M03B6.3 Protein of unknown function M03B6.4 M03B6.4 Protein of unknown function M03C11.1 M03C11.1 Serine/threonine protein kinase with similarity to human and D. melanogaster cAMP-dependent kinases, G protein-coupled receptor kinases and ribosomal protein S6 kinases cAMP-dependant protein kinase M03C11.2 M03C11.2 Protein with low similarity to DEAD-H box protein 11 (human DDX11), which is a DNA helicase that may function in maintaining the fidelity of chromosome segregation during mitosis CHL1 protein M03C11.3 M03C11.3 Protein of unknown function M03C11.4 M03C11.4 Protein of unknown function, has a region of low similarity to histone acetyltransferase 1 (human HAT1), which acetylates soluble newly synthesized histone H4 at Lys5 and Lys12 and histone H2A at Lys5 and may target chromatin factors to histone substrates M03C11.5 M03C11.5 Member of the ATPases associated with various cellular activities (AAA) protein family ATP-binding protein (AAA protein family member) M03C11.6 M03C11.6 Protein of unknown function M03C11.7 M03C11.7 Protein with moderate similarity to U4/U6-associated RNA splicing factor 3P (human HPRP3P), which is a component of the spliceosome that may be necessary for the splicing reaction M03C11.8 M03C11.8 Protein containing a helicase conserved C-terminal domain and an SNF2 related N-terminal domain, has low similarity to S. cerevisiae Yal019p, which is involved in resistance to UV radiation helicase M03D4.1 M03D4.1 Putative ortholog of C. elegans zen-4 gene product kinesin-like protein; The zen-4 gene encodes a kinesin-like protein. M03D4.3 M03D4.3 Protein of unknown function M03D4.4 M03D4.4 Protein containing seven C2H2 type zinc finger domains, which bind nucleic acids, has a region of low similarity to a region of zinc-finger protein 91 (human ZNF91), which is a transcriptional repressor that may play a role in formation of seminomas zinc-finger protein M03D4.6 M03D4.6 Protein containing a piwi domain and a PAZ (Piwi, Argonaut and Zwille) domain, which may mediate protein-protein interactions, has a region of low similarity to a region of C. elegans ALG-1, which plays role in the production of small temporal RNA M03E7.1 M03E7.1 Protein containing a major sperm protein (MSP) domain, which are involved in sperm motility M03E7.2 M03E7.2 Protein of unknown function M03E7.3 M03E7.3 Protein of unknown function M03E7.4 M03E7.4 Protein containing two low-density lipoprotein (LDL) receptor class A domains and a chitin binding peritrophin-A domain, has a region of low similarity to a region of sortilin-related receptor (human SORL1), which is a mosaic receptor LDL receptor-related protein M03E7.5 M03E7.5 Protein with low similarity to membrin (rat Gosr2), which functions in intracellular transport of proteins between the endoplasmic reticulum and Golgi M03F4.2 act-4;M03F4.2 Actin actin; An actin that is expressed in body wall and vulval muscles and the spermatheca. M03F4.3 M03F4.3 Member of the rhodopsin family of G protein-coupled receptors (GPCR), has low similarity to 5-hydroxytryptamine (serotonin) 1A receptor (mouse Htr1a), which inhibits adenylyl cyclase and plays a role in anxiety, aggression, sleep and feeding behavior G-protein coupled receptor M03F4.4 M03F4.4 Protein of unknown function M03F4.5 M03F4.5 Protein containing an EB module domain M03F4.6 M03F4.6 Protein containing an EB module domain, has weak similarity to a region of tenascin-X (mouse Tnxb), which is an extracellular matrix glycoprotein that may play a role in angiogenesis M03F4.7 M03F4.7 Protein with high similarity to calumenin (human CALU), which may serve in Ca2+-dependent processes in the ER, immunological defense and amyloidosis, contains five EF hand domains, which are found in signaling, buffering or transport proteins calcium binding protein M03F4.8 M03F4.8 Protein of unknown function, has a region of moderate similarity to a region of phosphatidylinositol 4-kinase type II (rat Pi4KII), which is a membrane-bound phosphatidylinositol kinase that phosphorylates inositol and interacts with Lck tyrosine kinase M03F8.1 M03F8.1 Protein of unknown function, has weak similarity to uncharacterized C. elegans ZK596.3 M03F8.2 M03F8.2 Protein containing one uncharacterized domain DUF6 M03F8.3 M03F8.3 Protein containing ten HAT (Half A TPR) repeats, which are found in several RNA processing proteins, has moderate similarity to S. cerevisiae Clf1p, which is an essential pre-mRNA splicing factor M03F8.4 M03F8.4 Protein of unknown function, has weak similarity to C. elegans ZK488.6 M03F8.5 M03F8.5 Member of uncharacterized DUF229 family, has low similarity to uncharacterized C. elegans F07C3.3 M03F8.6 M03F8.6 Protein of unknown function M04B2.1 mep-1;M04B2.1 Protein containing twelve C2H2 type zinc finger domains, which bind nucleic acids zinc-finger protein; mep-1 is required for repression by the fem-3 3' UTR in vivo, and for maintenance of somatic (versus germline) differentiation; MEP-1 protein has zinc-finger domains and a glutamine/asparagine-rich domain. M04B2.2 M04B2.2 Protein containing one thiouridine synthase, methylase or pseudouridine synthase (THUMP) domain, which may bind RNA, has low similarity to uncharacterized human DKFZP434F091 M04B2.3 gfl-1;M04B2.3 Required for RNA interference (RNAi); has high similarity to H. sapiens GAS41, the gene of which is amplified in glioblastomas Human AF-9 protein like; gfl-1 encodes an ortholog of human GLIOMA-AMPLIFIED SEQUENCE-41 (GAS41; OMIM:602116, found in increased copy number in low-grade glioma); loss of GLF-1, which is predicted to associate with chromatin, results in potent suppression of the RNA interference (RNAi) mechanism; GLF-1 is also similar to the transcription factors (yeast and human) AF-9 and human ENL, and thus may represent a novel class of transcription factors. M04B2.4 M04B2.4 Member of the FAD dependent oxidoreductase family, which catalyze oxidation of D-amino acids into the corresponding keto acids, has weak similarity to a region of sarcosine dehydrogenase (rat Sardh), which catalyzes oxidative sarcosine demethylation M04B2.5 twk-13;M04B2.5 Member of the potassium channel TWK-13 protein family potassium channel protein M04C3.1 M04C3.1 Protein containing an SNF2 related N-terminal domain, has high similarity to uncharacterized C. elegans C25F9.5 M04C3.2 M04C3.2 Protein of unknown function, has strong similarity to uncharacterized C. elegans C25F9.4 M04C3.3 M04C3.3 Protein of unknown function, has moderate similarity to uncharacterized C. elegans F58F9.3 M04C7.1 gpa-15;M04C7.1 Member of the G protein alpha subunit family guanine nucleotide-binding protein; gpa-15 encodes a member of the G protein alpha subunit family of heterotrimeric GTPases; it is expressed in ADL, ASH, ASK, PHA, PHB, the distal tip cell, the anchor cell, and many male-specific neurons. M04C7.2 M04C7.2 Member of the reverse transcriptase protein family, which are RNA-dependent DNA polymerases, has high similarity to uncharacterized C. elegans F22B3.3 reverse transcriptase M04C7.3 M04C7.3 Protein of unknown function, has moderate similarity to uncharacterized C. elegans Y71A12B.Q M04C9.1 M04C9.1 Protein of unknown function, has low similarity to uncharacterized C. elegans F16H6.5 M04C9.2 M04C9.2 Protein of unknown function M04C9.3 M04C9.3 Protein of unknown function, has low similarity to uncharacterized human FLJ20208 M04C9.4 M04C9.4 Protein of unknown function, has low similarity to uncharacterized C. elegans F23C8.11 M04C9.5 M04C9.5 Serine/threonine protein kinase with similarity to cyclin-dependent protein kinases serine/threonine kinase (CDC2/CDKX subfamily) M04C9.6 M04C9.6 Protein containing 18 HEAT repeat domains, which appear to function as protein-protein interaction surfaces, has a region of weak similarity to a region of the 65 kDa regulatory subunit of protein phosphatase 2A (S. pombe Paa1p) M04D8.1 ins-21;M04D8.1 Insulin-like protein of the type-alpha subfamily M04D8.2 ins-22;M04D8.2 Insulin-like protein of the type-alpha subfamily ins-22 encodes predicted type-alpha insulin-like molecule that lacks a C peptide domain and does not have an A6/A11 disulfide bond; expressed throughout development in some neurons beginning in the four-fold elongated embryo. M04D8.3 ins-23;M04D8.3 Insulin-like protein of the type-alpha subfamily ins-23 encodes an insulin-like peptide of the insulin superfamily of proteins (OMIM:176730, 147440); INS-23 is one of 38 insulin-like peptides in C. elegans, and is expressed in amphid sensory neurons, labial neurons, the nerve ring, and ventral nerve cord neurons; as loss of INS-23 function via RNA-mediated interference does not results in any abnormalities, the precise role of INS-23 in C. elegans development is not yet clear. M04D8.4 M04D8.4 Protein of unknown function M04D8.5 M04D8.5 Protein of unknown function M04D8.6 M04D8.6 Protein of unknown function M04D8.7 M04D8.7 Protein with moderate similarity to C. elegans C05B5.6 gene product M04F3.1 M04F3.1 Protein with weak similarity to replication protein A2 (human RPA2), which is the second subunit of the single-stranded DNA-binding protein complex replication protein A and has roles in DNA replication, repair, and recombination M04F3.2 M04F3.2 Protein of unknown function, has strong similarity to C. elegans K09H9.6 M04F3.3 M04F3.3 Protein with similarity to serine/threonine protein kinases of the casein kinase I subfamily, has similarity to S. cerevisiae Yck1p and Yck2p casein kinase I isoforms protein kinase M04F3.4 M04F3.4 Protein with high similarity to programmed cell death 6 (apoptosis-linked gene 2, mouse Pdcd6), which may mediate calcium-regulated signals needed for apoptosis, contains four EF hand domains, which are found in signaling, buffering or transport proteins calcium binding protein M04F3.5 M04F3.5 Protein of unknown function M04G12.1 M04G12.1 Protein of unknown function M04G12.2 M04G12.2 Putative cysteine protease , has strong similarity to human CTSZ (cathepsin Z) cysteine protease M04G12.3 gcy-34;M04G12.3 Protein containing an adenylate and guanylate cyclase catalytic domain, has low similarity to beta 2 subunit of guanylate cyclase (rat Gucy1b2), which is a subunit of guanylate cyclase that converts GTP to cGMP and is a part of the nitric oxide receptor guanylate cyclase beta chain like; gcy-34 encodes a predicted soluble guanylyl cyclase that is expressed in four candidate sensory neurons connected to the pseudocoelom, URXL, URXR, AQR, and PQR; as loss of gcy-34 activity via RNA-mediated interference does not result in any abnormalities, the precise role of GCY-34 in C. elegans development and/or behavior is not yet known; GCY-34 expression in neurons connected to the pseudocoelom suggests, however, that GCY-34 may play a role in fluid homeostasis. M04G12.4 M04G12.4 Protein containing a C2H2 type zinc finger domain, which bind nucleic acids Zinc finger, C2H2 type M04G7.1 M04G7.1 Protein containing a DUF18 domain of unknown function, has low similarity to uncharacterized C. elegans C46H11.9 M04G7.2 M04G7.2 Member of the protein-tyrosine phosphatase family, which are involved in control of cell growth, proliferation, differentiation and transformation, has a region of moderate similarity to a region of human PTPRA, which is a receptor tyrosine phosphatase protein-tyrosine phosphatase M04G7.3 M04G7.3 Protein of unknown function, has moderate similarity to uncharacterized C. elegans F56A12.2 M05B5.1 M05B5.1 Member of the protein-tyrosine phosphatase family, which are involved in control of cell growth, proliferation, differentiation and transformation, has weak similarity to rat Ptpn2, which is a non-receptor protein tyrosine phosphatase protein-tyrosine phosphatase M05B5.2 myo2-B;M05B5.2 Protein with moderate similarity to C. elegans F28B4.4 gene product M05B5.3 M05B5.3 Protein of unknown function M05B5.4 M05B5.4 Protein with high similarity to LCAT-like lysophospholipase (human LYPLA3), which hydrolyzes lysophosphatidylcholine and is involved in lipoprotein metabolism, member of the lecithin-cholesterol acyltransferase family phosphatidylcholine-sterol acyltransferase; The M05B5.4 gene encodes an ortholog of the human gene LECITHIN-CHOLESTEROL ACYLTRANSFERASE (LCAT; OMIM:606967), which when mutated leads to lecithin-cholesterol acyltransferase deficiency (OMIM:245900). M05B5.5 hlh-2;CeDA;M05B5.5 Helix-loop-helix DNA-binding domain family member; important for specification of male tail ray, non-striated muscle, and some neural cell fates transcription factor E2-A like; hlh-2 encodes a Class I basic helix-loop-helix (bHLH) transcription factor that is the C. elegans ortholog of the mammalian E and Drosophila Daughterless transcriptional activators; HLH-2 activity is required for cell fate specifications occuring during embryonic and larval development that affect such processes as gonadogenesis, male tail formation, and programmed cell death; HLH-2 has been shown to dimerize with at least two C. elegans Acheate-scute homologs, LIN-32, a neural-specific protein with which it functions in male tail development and HLH-3, with which it is coexpressed in the nuclei of embryonic neuronal prescursors and with which it regulates the transcription of the EGL-1 cell death activator in the NSM sister cells; in gonadogenesis, HLH-2 is required for bestowing proAC competence on the cells that undergo the AC/VU (anchor cell/ventral uterine precursor) cell fate decision, for specification, differentiation, and function of the distal tip cell (DTC) and AC, including transcriptional regulation of the LAG-2 Delta-like ligand in the latter, and for formation of the uterine seam cell (utse); genetic analysis also suggests that HLH-2 functions with HLH-14, an additional Acaete-scute homolog, to specify the PVQ/HSN/PHB neuroblast cell lineage; HLH-2 is expressed in all nuclei of early embryos until the ~200-cell stage, when expression becomes increasingly restricted to neuronal cells and their immediate precursors; later expression is detected in, but not limited to, pharyngeal cells, anterior neurons, vulval and uterine muscles, the DTCs, the presumptive and mature AC, the Q neuroblast, and enteric muscles; comparative analysis of transcriptional and translational reporters indicates that hlh-2 is expressed in both the anchor cell and the ventral uterine (VU) precursor, but that expression in the latter is subject to post-transcriptional down-regulation; HLH-2 accumulation in the presumptive AC is the first detectable difference between the AC and VU precursors during the lateral specification event that distinguishes these two cell fates. M05B5.6 M05B5.6 Putative transmembrane protein, has weak similarity across the middle region to H. sapiens ANKTM1 (ankyrin-like with transmembrane domains 1) and C. elegans ankyrin-repeat protein C29E6.2 M05D6.1 M05D6.1 Serine/threonine protein kinase of the casein kinase I subfamily, has similarity to S. cerevisiae Hrr25p casein kinase I serine/threonine kinase M05D6.2 M05D6.2 Protein with weak similarity to T-complex protein 11 mouse (Tcp11), which plays a role in sperm function regulation, capacitation stimulation and inhibition of the spontaneous acrosome reaction testis-specific like protein M05D6.3 M05D6.3 Member of the protein-tyrosine phosphatase family, which are involved in control of cell growth, proliferation, differentiation and transformation, has a region of low similarity to a region of human PTPN9, which is a non-receptor tyrosine phosphatase protein-tyrosine-phosphatase M05D6.4 M05D6.4 Protein of unknown function, has moderate similarity to uncharacterized C. elegans ZK945.1 esterase M05D6.5 M05D6.5 Protein of unknown function, has weak similarity to C. elegans T20D3.6 M05D6.6 M05D6.6 Protein of unknown function M05D6.7 M05D6.7 Protein with weak similarity to butyrobetaine (gamma) 2-oxoglutarate dioxygenase (gamma-butyrobetaine hydroxylase) 1 (human BBOX1), which catalyzes the conversion of gamma butyrobetaine to L-carnitine in carnitine biosynthesis gamma-butyrobetaine,2-oxoglutarate dioxygenase; gbh-2 encodes an ortholog of human gamma butyrobetaine hydroxilase 2 involved in carnitine biosynthesis; RNA interference of gbh-2 results in malformation of the gonad and accumulation of fat in the pseudocoelomic cavity and in intestinal cells; the GBH-2-GFP fusion protein is predominantly expressed in intestinal cells from early embryogenesis. M106.1 mix-1;let-29;M106.1 Component of the C. elegans dosage compensation complex; involved in meiosis and X chromosome dosage compensation mitotic chromosome and X-chromosome associated MIX-1 protein; The mix-1 gene encodes a homolog of SMC2 involved in chromosome segregation, X-chromosome gene regulation, and repression of X-linked genes during dosage compensation. M106.2 M106.2 Protein of unknown function M106.3 M106.3 Protein with similarity to NADP-dependent oxidoreductases, has similarity over C-terminal 130 amino acids to human zeta-crystallin/quinone reductase CRYZ Zinc-binding dehydrogenases M106.4 M106.4 Protein with high similarity to guanine monophosphate synthetase (human GMPS), which aminates xanthosine 5'-monophosphate to form GMP, member of the glutamine amidotransferase class I (trpG-type) family, contains a GMP synthase C terminal domain GMP synthase; M106.4 is orthologous to human GUANINE MONOPHOSPHATE SYNTHETASE (GMPS; OMIM:600358), a partner gene of MLL in treatment-related acute myeloid leukemia with the karyotype t(3;11)(q25;q23). M106.5 cap-2;M106.5 Member of the F-actin capping protein beta subunit protein family F-actin capping protein beta subunit; The beta subunit of actin capping protein that regulates actin cytoskeleton assembly and establishment of initial asymmetry in the embryo; it is expressed in the cytoplasm of all cells in the embryo. M110.1 M110.1 Protein containing two collagen triple helix repeats, which are found in some extracellular proteins, and a nematode cuticle collagen N-terminal domain, has a region of moderate similarity to a region of collagen type XI alpha 2 subunit (human COL11A2) collagen M110.2 twk-14;M110.2 Member of the 4 TM potassium channel protein family M110.3 M110.3 Protein with weak similarity to S. cerevisiae SSM4 (Protein involved in mRNA turnover) M110.4 M110.4 Protein containing a MIF4G (middle domain of eukaryotic initiation factor 4G) domain, has weak similarity to S. cerevisiae Tif4632p, which is the 130 kDa subunit of the mRNA cap-binding protein (eIF4F) eukaryotic initiation factor; ifg-1 encodes, by alternative splicing, two orthologs of the translational initiation factor eIF4 (eIF-4) gamma. M110.5 M110.5 Protein with strong similarity to human and D. melanogaster DISABLED (DAB) proteins (tyrosine protein kinase substrates; human DAB2 associated with ovarian cancer) disabled-like protein M110.6 M110.6 Protein of unknown function, has high similarity to uncharacterized C. elegans K09H9.4 reverse transcriptase M110.7 M110.7 Member of the UPF0028 protein family, contains a cyclic nucleotide-binding domain, has moderate similarity to a region of neuropathy target esterase (human NTE), which is a carboxylesterase that is associated with organophosphate delayed neuropathy Uncharacterized protein family UPF0028 M116.2 M116.2;mut-2 Protein of unknown function, has high similarity to a region of glycogenin-1 (glycogenin glucosyltransferase 1, mouse Gyg1), which is an autocatalytic enzyme that primes de novo glycogen synthesis and acts as its own substrate glycogenin glucosyltransferase M116.3 M116.3;mut-2 Putative paralog of C. elegans Tc5 transposase T13C2.1 transposase M117.1 M117.1 Protein with similarity to human and D. melanogaster sodium-dependent inorganic phosphate cotransporters, member of the major facilitator superfamily sodium/phosphate transporter M117.2 ftt-1;M117.2 Fourteen-three-three protein that has a role in maintaining the anterior-posterior boundary at the embryonic cortex 14-3-3 protein; PAR-5 is a 14-3-3 protein. M117.3 M117.3 Member of the 14-3-3 protein family, which are found in mammalian brain cells, has high similarity to a region of C. elegans FTT-1, which has a role in maintaining the anterior-posterior boundary at the embryonic cortex 14-3-3 protein M117.4 M117.4 Protein of unknown function, has high similarity to uncharacterized C. elegans Y39G10AR.15 M117.5 M117.5 Member of an uncharacterized protein family This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins; its encoded protein also contains a Pfam-B45 motif of presently unknown function. M142.1 unc-119;M142.1 Neuronal protein required for coordinated movement ; suppresses axon branching and maintains the structure of the nervous system unc-119 encodes a novel protein that is highly conserved amongst metazoans; unc-119 activity is required for proper development of the nervous system, including axonal branching and fasciculation, and hence, for normal movement, chemosensation, and feeding; unc-119 is expressed pan-neuronally beginning in the early embryo (~60 cells) and continuing through adulthood; although the molecular function of UNC-119 is not yet known, human UNC119, which can rescue C. elegans unc-119 mutant animals, is reported to function as a receptor-associated activator of signal transduction; thus, UNC-119 may be part of a signal transduction pathway that mediates axonal patterning in response to external developmental cues. M142.2 M142.2 Protein containing a von Willebrand factor (vWF) type A domain, has a region of moderate similarity to a region of cuticulin component (C. elegans CUT-1) cuticulin M142.4 vab-7;M142.4 Member of the homeobox (HOX) family of DNA-binding proteins; required for posterior patterning homeobox protein (even-skipped subfamily); The vab-7 gene encodes an even-skipped-like homeodomain protein that is required for DB motoneuron identity and posterior DB axonal polarity. M142.5 M142.5 Protein of unknown function M142.6 M142.6 Protein with moderate similarity to C. elegans K08E3.3 gene product Zinc finger, C3HC4 type (RING finger) M151.1 M151.1 Protein with moderate similarity to C. elegans C01B4.2 gene product M151.2 M151.2 Putative ortholog of C. elegans M151.3 gene product M151.3 M151.3 Putative ortholog of C. elegans M151.2 gene product M151.4 M151.4 Putative coiled-coil protein, possible paralog of C. elegans M151.3 and M151.2, has weak similarity to myosin heavy chains M151.5 M151.5 Putative ortholog of C. elegans M151.6 gene product M151.6 M151.6 Protein of unknown function, has low similarity to uncharacterized C. elegans W08F4.2 M151.7 M151.7 Putative coiled-coil protein M153.1 M153.1 Putative pyrroline-5-carboxylate reductase, has strong similarity to human, D. melanogaster and S. cerevisiae pyrroline-5-carboxylate reductases pyrroline-5-carboxylate reductase M153.2 M153.2 Protein of unknown function, has high similarity to uncharacterized C. elegans F36G9.3 M153.3 M153.3 Protein with strong similarity to C. elegans T24C12.4 gene product M162.1 M162.1 Protein of unknown function, has moderate similarity to uncharacterized C. elegans Y51A2A.6 M162.2 M162.2 Member of the C-type lectin family M162.3 M162.3 Protein containing a DUF32 domain of unknown function, has strong similarity to uncharacterized C. elegans M162.4 M162.4 M162.4 Protein containing a DUF32 domain of unknown function, has strong similarity to uncharacterized C. elegans M162.3 M162.5 M162.5 Member of the sugar (and other) transporter family, has weak similarity to human SLC17A7, which is a brain-specific Na+-dependent inorganic phosphate cotransporter that localizes exclusively to neuron-rich regions M162.6 M162.6 Protein with moderate similarity to C. elegans M162.1 gene product M162.7 M162.7 Protein containing a WSN domain of unknown function, has high similarity to uncharacterized C. elegans Y51A2B.6 M162.8 M162.8 Member of an uncharacterized protein family This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins; this gene's encoded protein also contains an FTH/DUF38 motif, which may also mediate protein-protein interaction. M163.1 M163.1 Protein of unknown function M163.2 M163.2 Protein with weak similarity to C. elegans tra-1, which is a zinc-finger transcription factor involved in sex determination Zinc finger, C2H2 type M163.3 his-24;M163.3 Histone H1, 21.5 kDa form histone H1; The his-24 gene encodes a histone H1 isoform (H1.1) that is essential for chromatin silencing and germline development. M163.4 apc-5;M163.4 Protein of unknown function, has moderate similarity to uncharacterized C. elegans Y66D12A.17 gfi-3 is also known as apc-5, encoding a distant homolog of the human anaphase promoting complex subunit APC5, but is most closely related to its C. elegans paralog Y66D12A.17; gfi-3(RNAi) animals are generally unable to progress through meiotic divisions; initially they produce reduced numbers of viable embryos mixed with inviable embryos, but then show severe germline maintenance defects and become sterile. M163.5 M163.5 Protein of unknown function M163.6 M163.6 Protein of unknown function M163.7 M163.7 Protein of unknown function M176.1 M176.1 Protein of unknown function, has low similarity to uncharacterized C. elegans Y17G7B.11 tag-50 encodes a predicted member of the arrestin family. M176.10 M176.10 Protein of unknown function M176.2 M176.2 Protein with moderate similarity to glutathione synthetase (human GSS), which catalyzes the final step of glutathione synthesis and is implicated in metabolic acidosis, 5 oxoprolinuria, neurological dysfunction, or hemolytic anemia upon deficiency glutathione synthase; M176.2 is orthologous to the human gene GLUTATHIONE SYNTHETASE (GSS; OMIM:601002), which when mutated leads to 5-oxoprolinuria, or to GSS deficiency restricted to erythrocytes and associated only with hemolytic anemia. M176.3 M176.3 Protein of unknown function M176.4 M176.4 Protein of unknown function M176.5 M176.5 Protein of unknown function M176.6 kin-15;M176.6 Putative receptor tyrosine protein kinase, has similarity to human and D. melanogaster fibroblast growth factor receptor-related protein kinases tyrosine-protein kinase (KIN15/KIN16 subfamily) M176.7 kin-16;M176.7 Putative receptor tyrosine protein kinase, has similarity to human and D. melanogaster fibroblast growth factor receptor-related protein kinases tyrosine-protein kinase (KIN15/KIN16 subfamily) (2 domains); kin-16 encodes a predicted receptor protein tyrosine kinase; like kin-15, with which it is cotranscribed, kin-16 encodes a protein that displays some unusual features, including a very small extracellular domain (50 amino acids) that lacks a cysteine-rich region typical of ligand-binding domains of known receptor tyrosine kinases, an unusual amino acid substitution in the subdomain VI motif, and a lack of typical autophosphorylation sites in the kinase insert and C-terminal domains; genetic analysis suggests that kin-16 may be required for normal rates of larval development and for fecundity; a kin-16 reporter is first detected in young L1 larvae in the hypodermal cells that make up the hyp7 syncytium; later expression is detected in ventral and lateral cells that fuse with hyp7 as well as in the more anterior hyp6 syncytium; this distinct expression pattern suggests that kin-16 may also play a role in development of the hypodermal syncytium and perhaps be involved in cell-cell interactions regulating cell fusion during postembryonic development. M176.8 M176.8 Member of the glycosyl hydrolase 18 family, has high similarity to uncharacterized C. elegans R09D1.3 chitinase M176.9 M176.9 Protein containing a Src homology 2 (SH2) domain, which are regulatory modules of intracellular signaling, contains a protein kinase domain, has low similarity to fer (fps/fes related) tyrosine kinase (mouse Fert2), which may mediate cell-cell signaling M18.1 M18.1 Protein containing two collagen triple helix repeats, which are found in some extracellular proteins, and a nematode cuticle collagen N-terminal domain, has a region of high similarity to a region of C. elegans BLI-1 collagen M18.2 M18.2 Member of the dynein light chain type 1 family, has moderate similarity to dynein light chain (protein inhibitor of neuronal nitric oxide synthase) (rat Pin), which is a component of the dynein motor complex that acts as a nitric oxide synthase inhibitor dynein like M18.3 M18.3 Protein of unknown function, has low similarity to uncharacterized human FLJ20752 M18.5 M18.5 Protein with moderate similarity to damage-specific DNA-binding protein 1 (human DDB1), which is a larger subunit of a complex that recognizes and binds damaged DNA and stimulates repair and is associated with xeroderma pigmentosum DNA repair protein like; M18.5 is orthologous to the human gene DAMAGE-SPECIFIC DNA BINDING PROTEIN 1 (127KD) (DDB1; OMIM:600045), which when mutated leads to disease. M18.6 M18.6 Protein of unknown function M18.7 M18.7 Protein of unknown function, has high similarity to uncharacterized C. elegans F23B2.6 RNA recognition motif. (aka RRM, RBD, or RNP domain) M18.8 M18.8 Protein containing a DHHC-type zinc finger (NEW1) domain, has a region of moderate similarity to a region of huntingtin interacting protein H (human HYPH), which interacts with huntingtin (HD) and this interaction may be altered in Huntington's disease M195.1 M195.1 Protein containing two collagen triple helix repeats, which are found in some extracellular proteins and a nematode cuticle collagen N-terminal domain, has low similarity to C. elegans MEC-5 cuticle collagen M195.2 M195.2 Protein containing six uncharacterized DUF139 cysteine repeat domains, has low similarity to uncharacterized C. elegans R09B5.5 M195.3 M195.3 Member of the ammonium transporter family of membrane transporters, has a region of low similarity to S. cerevisiae Mep2p, which is an ammonia permease of low capacity and high affinity NH(4+) transporter; amt-3 encodes one of four C. elegans homologs of AMT1 (AT11_ARATH), a high-affinity ammonium transporter from Arabidopsis thaliana; AMT-3 is closely similar to its paralog AMT-2, with somewhat more distant paralogy to AMT-1 and AMT-4. M195.4 M195.4 Protein with moderate similarity to C. elegans T08H10.3 gene product M199.1 M199.1 Protein containing a DUF32 domain of unknown function, has high similarity to uncharacterized C. elegans Y41E3.12 M199.2 M199.2 Protein containing a major sperm protein (MSP) domain, which are involved in sperm motility, has a region of high similarity to C. elegans MSP-10, which is involved in oocyte maturation MSP (Major sperm protein) domain. M199.3 M199.3 Protein of unknown function, has weak similarity to C. elegans Y77E11A_3443.O M199.4 M199.4 Protein with similarity to members of the C-type lectin family M28.1 M28.1 Protein of unknown function, has a region of moderate similarity to a region of C. elegans CUT-1, which is a cuticulin component cuticulin 1 M28.2 M28.2 Protein of unknown function, has high similarity to uncharacterized C. elegans M28.9 M28.4 M28.4 Protein of unknown function, has moderate similarity to uncharacterized C. elegans M28.8 M28.5 Snu13ce;M28.5 Putative component of the U4/U6.U5 snRNP complex, putative ortholog of S. cerevisiae Snu13p, member of the ribosomal L7Ae protein family ribosomal protein (L7AE family) M28.6 M28.6 Protein of unknown function, has moderate similarity to uncharacterized C. elegans ZK945.1 esterase M28.7 M28.7 Protein containing a Src homology 3 (SH3) domain, which bind proline-rich peptides, has weak similarity to nephrocystin (mouse Nphp1), which associates with Cas, tensin and Pyk2 and may function in polarized epithelial cell-cell contacts SH3 domain M28.8 M28.8 Protein of unknown function, has moderate similarity to uncharacterized C. elegans M28.9 M28.9 M28.9 PRotein of unknown function, has high similarity to uncharacterized C. elegans M28.2 M4.1 M4.1 Protein containing a forkhead associated (FHA) domain, which bind phosphopeptides M4.2 M4.2 Protein containing four Pumilio-family (Puf) RNA binding domains, has low similarity to C. elegans FBF-1, which is an RNA-binding protein involved in sex determination M57.1 M57.1 Protein of unknown function, has high similarity to uncharacterized C. elegans B0212.3 M57.2 M57.2 Putative prenyltransferase, has strong similarity to human Rab geranylgeranyltransferase, alpha subunit, RABGGTA (Hs.78920) M6.1 ifc-2;M6.1;Cel-IF-C2 Member of the intermediate filament family, which are components of the cytoskeleton and nuclear envelope intermediate filament proteim A; ifc-2 encodes three isoforms of an intermediate filament protein dispensable for viability but required for normal movement, growth rate, body size, body shape, and cuticle strength; IFC-2 is present in the cytoplasm of intestinal cells, and at the desmosomes of intestinal and pharyngeal cells. M6.3 M6.3 Protein containing a homeobox domain (homeodomain), which are found in transcription factors, has a region of moderate similarity to a region of hematopoietically expressed homeobox (human HHEX), which is a transcriptional repressor homeobox protein M6.4 M6.4 Protein of unknown function M60.1 M60.1 Protein of unknown function, has low similarity to a region of serine protease 22 (placental protein 11, human P11), which is a serine protease that may be useful as a diagnostic marker for ovary adenocarcinoma and breast carcinoma M60.2 M60.2 Protein of unknown function, has a region of low similarity to serine protease 22 (placental protein 11, human P11), which is a serine protease that may be useful as a diagnostic marker for ovary adenocarcinoma and breast carcinoma M60.3 M60.3 Protein of unknown function M60.4 M60.4 Protein of unknown function M60.5 klq-2;M60.5;nKQT2 Putative KQT potassium channel; a human homolog of which is indicated in long QT syndrome channel protein; kqt-2 encodes a predicted M-type potassium channel for which mutations in humans are associated with heredity diseases that affect epithelial cells, cardiac muscle and neurons, and affects defecation cycle intervals in C. elegans; may function as a heterotrimeric channel with KQT-3 based on genetic evidence and is expressed in intestinal cells. M60.6 M60.6 Protein of unknown function M60.7 M60.7 Protein containing nine ankyrin (Ank) repeats, which may mediate protein-protein interactions, has low similarity to a region of ankyrin 1 (human ANK1), which is a cytoskeletal anchor protein that attaches cytoskeletal elements to the plasma membrane M7.1 let-70;ubc-2;M7.1 Ubiquitin-conjugating enzyme required for viability ubiquitin-conjugating enzyme E2-17 KD M7.10 M7.10 Protein containing a DUF148 domain of unknown function, has high similarity to uncharacterized C. elegans C28C12.3 M7.12 M7.12 Protein of unknown function, has high similarity to uncharacterized C. elegans M7.8 M7.13 str-3;M7.13 Member of the 7-transmembrane chemoreceptor family of G protein-coupled receptors (GPCR), has low similarity to C. elegans ODR-10, which is involved in odorant response str-3 encodes a seven transmembrane chemosensory receptor; STR-3 is expressed in the ASI chemosensory neurons; STR-3 expression in ASI is repressed in the presence of dauer pheromone at concentrations lower than that which induces dauer formation. M7.2 klc-1;M7.2 Putative kinesin light chain, possible ortholog of human and D. melanogaster kinesins kinesin M7.3 M7.3 Protein containing a SAM (sterile alpha motif) domain, which may mediate protein-protein interactions, contains a KH domain, which may bind RNA, has weak similarity to uncharacterized mouse Bicc1 KH domain family of RNA binding proteins.; bcc-1 encodes a homolog of Drosophila and vertebrate Bicaudal C (BICC) that contains KH RNA-binding domains, a serine-rich region, and a SAM (sterile alpha motif) domain; by homology, BCC-1 is predicted to function as a cytoplasmic RNA-binding protein that is required for translational regulation and/or mRNA stability during embryonic or germline development; however, as loss of bcc-1 activity via large-scale RNAi screens does not result in any obvious abnormalities, the precise role of BCC-1 in C. elegans development and/or behavior is not yet known. M7.5 M7.5 Putative ortholog of S. cerevisiae Apg7p, a protein involved in autophagy and the cytoplasm-to-vacuole protein targeting pathway Yeast YHX1 like M7.7 M7.7 Serine/threonine protein kinase of the casein kinase I subfamily, has similarity to S. cerevisiae Yck1p, Hrr25p, and Yck2p casein kinase I isoforms serine/threonine kinase M7.8 M7.8 Protein of unknown function, has high similarity to uncharacterized C. elegans M7.12 M7.9 M7.9 Protein containing a DUF148 domain of unknown function M70.3 M70.3 Putative ortholog of C. elegans M70.D gene product M70.B M70.B Putative paralog of C. elegans M70.4 M70.C M70.C Protein of unknown function, has strong similarity to C. elegans Y105C5.U M70.D M70.D Protein of unknown function, putative paralog of C. elegans M70.F M70.E M70.E Protein of unknown function, putative paralog of C. elegans M70.2 M70.F M70.F Protein of unknown function, putative paralog of C. elegans M70.D M79.1 abl-1;Cehd-15;M79.1 Putative tyrosine protein kinase, putative ortholog of human and D. melanogaster Abelson proto-oncogene homologs Src homology domain 2, Src homology domain 3, protein tyrosine kinase (ABL subfamily); abl-1 encodes a Src homology (SH) 2 and 3 domain-containing non-receptor tyrosine kinase of the ABL family, which negatively regulates germ cell apoptosis in response to ionizing radiation and which interacts genetically with ced-3 and ced-9, core components of the programmed cell death pathway; abl-1 mutations are suppresed by mutations in unc-34/enabled, a known modifier of abl activity in Drosophila, and hus-1, rad-5, and mrt-2 check point genes are required for the increased germ cell apoptosis seen in abl-1 mutant animals; ABL-1 is homologous to the mammalian proto-oncogene c-ABL (OMIM:189980) and to human CANALICULAR MULTIDRUG RESISTANCE PROTEIN (ABL2; OMIM:601107), which when mutated leads to Dubin-Johnson syndrome (OMIM:237500). M79.2 M79.2 Protein of unknown function, has weak similarity to C. elegans F49H12.B M79.3 M79.3 Protein with strong similarity to C. elegans F49H12.6 gene product M79.4 flp-19;M79.4 FMRF-amide-like-peptide neurotransmitter M88.1 M88.1 Protein containing a UDP-glucoronosyl and UDP-glucosyl transferase domain, has low similarity to UDP glycosyltransferase 2 family polypeptide B7 (human UGT2B7), which glucuronidates androgens, retinoids, lipids, and specific drugs UDP-glucuronosyltransferase M88.2 M88.2 Possible large ribosomal subunit protein M88.3 M88.3 Protein of unknown function, has moderate similarity to uncharacterized C. elegans F37A8.2 M88.4 M88.4 Protein of unknown function M88.5 M88.5 Protein containing four KH domains, which may bind RNA, has a region of low similarity to a region of IGF-II mRNA-binding protein 2 (human IMP-2), which binds to the 5' UTR of human IGF2 mRNA and may repress translation during late development hnRNP K; The protein product of this gene is predicted to contain a glutamine/asparagine (Q/N)-rich ('prion') domain, by the algorithm of Michelitsch and Weissman (as of the WS77 release of WormBase, i.e., in wormpep77). M88.6 M88.6 Protein containing twenty leucine rich repeats, which mediate protein-protein interactions, has a region of low similarity to a region of insulin-like growth factor binding protein acid-labile subunit (rat Igfals) Leucine-rich repeats M88.7 M88.7 Protein with weak similarity to D. melanogaster CG3420 (CG3420 gene product) MAB-18 mab-18 Homeodomain transcription factor involved in development of the male tail, has similarity over the homeodomain to many human and D. melanogaster homeodomain transcription factors MDF-2 mdf-2 Protein involved in mitotic genome stability and has strong similarity to mitotic feedback control protein, human MAD2 MED-1 med-1 GATA-type transcription factor MMP-Y19 MMP-Y19 Putative matrix metalloproteinase ND6M NU6M;ND6;ND6M Mitochondrial encoded, NADH-ubiquinone oxidoreductase chain 6 NHR-87 nhr-87 Putative nuclear hormone receptor transcription factor NHR-92 nhr-92 Putative nuclear hormone receptor transcription factor NU2M ND2;NU2M Mitochondrial encoded NADH-ubiquinone oxidoreductase chain 2 NU3M ND3;NU3M Member of the NADH-ubiquinone or plastoquinone oxidoreductase chain 3 family NU4M ND4;NU4M Member of the NADH-Ubiquinone or plastoquinone (complex I) family, which catalyze transfer of two electrons from NADH to ubiquinone, has low similarity to mitochondrial NADH dehydrogenase 4 (human MTND4), which is a NADH-ubiquinone oxidoreductase subunit NU5M ND5;NU5M Member of the NADH-Ubiquinone or plastoquinone (complex I) family, which catalyze transfer of two electrons from NADH to ubiquinone, has a region of moderate similarity to a region of NADH dehydrogenase subunit 5 (human MTND5) OCT-2 oct-2 Organic cation membrane transporter, member of the major facilitator superfamily PAR-4 par-4 Probable serine/threonine kinase required for the asymmetric distribution of P granules and other factors during embryogenesis PAR2.1 PAR2.1 Member of the prokaryotic single-stranded DNA binding family This gene encodes a protein predicted by Eisenberg and coworkers, with 68% accuracy, to be mitochondrial. PAR2.3 PAR2.3 Protein with strong similarity to human AMP-activated serine/threonine protein kinases and S. cerevisiae Snf1p serine/threonine protein kinase Protein kinase PAR2.4 PAR2.4 Protein of unknown function, has low similarity to uncharacterized human KIAA1402 PDB1.1 PDB1.1 Member of the cation efflux family, which may be membrane divalent cation transporters, has low similarity to uncharacterized C. elegans R02F11.3 PDK-1 pdk-1 Serine/threonine protein kinase; putative ortholog of human, D. melanogaster, and S. cerevisiae 3-phosphoinositide-dependent protein kinases PEX1 pex-1;pex1 Member of the AAA family of ATPases, has low similarity to peroxisome biogenesis factor 1 (human PEX1), which functions in peroxisomal protein import and is associated with Zellweger syndrome, neonatal adrenoleukodystrophy, and infantile Refsum disease PRA-1 pra-1 Protein with weak similarity to C. elegans Y92C3B.3 gene product R01B10.1 R01B10.1 Protein with strong similarity to C. elegans K08B4.6 gene product cli-1 encodes a protein that contains a cystatin-like domain. R01B10.2 R01B10.2 Protein with moderate similarity to C. elegans Y49E10.26 gene product R01B10.3 R01B10.3 Protein of unknown function R01B10.4 R01B10.4 Protein with low similarity to S. cerevisiae Ycr044p, which is a suppressor of the S. cerevisiae cdc1-1 temperature-sensitive growth defect and is involved in Mn2+ homeostasis R01B10.5 R01B10.5;5G528 Protein of unknown function, has low similarity to uncharacterized human HSPC213 R01E6.1 gcy-10;odr-1;R01E6.1 Putative guanylyl cyclase expressed in neurons and involved in chemosensation of volatile odorants guanylate cyclase; odr-1 encodes a putative guanylyl cyclase required for normal responses to all AWC-sensed odorants; it is expressed in chemosensory neurons. R01E6.2 R01E6.2 Protein of unknown function, has weak similarity to C. elegans F32A5.4 R01E6.3 R01E6.3 Protein containing three eukaryotic-type carbonic anhydrase domains, which catalyze reversible hydration of carbon dioxide, has low similarity to carbonic anhydrase 2 (human CA2), which hydrates carbon dioxide to form a bicarbonate ion and a proton carbonic anhydrase; cah-4 encodes a carbonic anhydrase homolog, which is rather divergent from other such homologs in C. elegans (with at most 38% identity to any other carbonic anhydrase, in or out of C. elegans); it is individually dispensable for viability and for grossly normal postembryonic morphology, and thus may have a more subtle biological function than the basic cytoprotective functions expected for carbonic anhydrases. R01E6.4 acr-12;R01E6.4 Protein containing two neurotransmitter-gated ion-channel ligand binding and two transmembrane domains, has moderate similarity to C. elegans UNC-38, which is a nicotinic acetylcholine receptor alpha subunit acetylcholine receptor protein; an ortholog of nicotinic acetylcholine receptor (nAChR). R01E6.5 R01E6.5 Protein of unknown function, has weak similarity to C. elegans Y39B6.X R01E6.6 R01E6.6 Protein with moderate similarity to C. elegans C36E8.2 gene product 951004: R01E6.6 has homology with C36E8.2 R01E6.7 R01E6.7 Protein of unknown function R01H10.1 R01H10.1 Protein with strong similarity to DNA polymerase alpha primase subunit B DNA polymerase alpha associated subunit; div-1 encodes a homolog of the B subunit of the DNA polymerase alpha-primase complex; DIV-1 is required in embryos for the normal timing of interphase in cell divisions, and for the asymmetric distribution of PIE-1 and P granules. R01H10.3 R01H10.3 Protein containing three WD domains (WD-40 repeat), which may mediate protein-protein interactions, has low similarity to coronin (S. cerevisiae Crn1p), which is an actin-binding protein Coronin (beta transducin); The cor-1 gene encodes an ortholog of the actin-binding protein coronin. R01H10.4 R01H10.4 Protein of unknown function, has low similarity to uncharacterized C. elegans T19C3.2 R01H10.5 R01H10.5 Protein of unknown function R01H10.6 R01H10.6 Protein of unknown function R01H10.7 R01H10.7 Protein with weak similarity to inositol polyphosphate-4-phosphatase I (rat Inpp4a), which is a Mg2+-independent enzyme hydrolyzes the position 4 phosphate of inositol polyphosphates and is involved in the inositol phosphate signaling pathway R01H10.8 R01H10.8 Protein containing PDZ, DHR, or GLGF, pleckstrin homology (PH), and SAM (sterile alpha motif) domains, has weak similarity to membrane-associated guanylate kinase-interacting protein 1 (rat LOC59322), which is involved in synaptic junction assembly PDZ domain (Also known as DHR or GLGF).; cnk-1 encodes a protein that contains a SAM domain, a PDZ domain, and a PH domain. R01H2.1 R01H2.1 Protein of unknown function R01H2.2 R01H2.2 Protein with moderate similarity to C. elegans F35E2.5 gene product R01H2.3 R01H2.3 Protein containing eight low-density lipoprotein (LDL) receptor class A domains, has low similarity to a region of low density lipoprotein receptor-related protein 1B (human LRP1B), which is involved in endocytosis and is inactivated in some lung cancers R01H2.4 R01H2.4 Protein with strong similarity to C. elegans Y66A7A.4 gene product R01H2.5 R01H2.5 Protein with high similarity to GDP-keto-6-deoxymannose 3 5-epimerase 4-reductase (human TSTA3), which catalyzes an epimerization and an NADPH-dependent reduction to convert GDP-4-keto-6-D-deoxymannose to GDP-L-fucose R01H2.6 R01H2.6 Protein with high similarity to ubiquitin-conjugating enzyme E2L 3 (human UBE2L3), member of the ubiquitin-conjugating enzyme (E2) family, which catalyze the covalent attachment of ubiquitin to target proteins ubc-18 encodes an E2 ubiquitin-conjugating enzyme related to human UBCH7 (OMIM:603731); UBC-18 activity is required for normal growth and reproduction, and UBC-18 functions redundantly with LIN-35/Rb and other class B synthetic multivulval (SynMuv) gene products to regulate pharyngeal morphogenesis during embryonic development; ubc-18 transcripts are detected in the germline, embryos, late larval stages, and adults, suggesting that UBC-18 may function maternally to regulate several aspects of C. elegans development; the substrates of UBC-18 are not yet known. R02C2.1 R02C2.1 Protein containing two protein kinase domains, has low similarity to ribosomal protein S6 kinase 2 (human RPS6KA3), which is a protein kinase involved in MAPK signaling that is required for epidermal growth factor (EGF)-stimulated H3 phosphorylation protein kinase R02C2.2 R02C2.2 Protein containing a protein kinase domain, has a region of moderate similarity to a region of human CHEK1, which is a protein kinase that inhibits mitotic entry after DNA damage via a mechanism that involves the phosphatase CDC25 protein kinase R02C2.3 R02C2.3 Member of the uncharacterized protein family UPF0063, has high similarity to uncharacterized C. elegans Y39H10A.2 R02C2.4 R02C2.4 Putative nuclear hormone receptor, has strong similarity to C. elegans F57A10.5 nuclear hormone receptor R02C2.5 R02C2.5 Member of the 7-transmembrane chemoreceptor family of G protein-coupled receptors (GPCR), has low similarity to C. elegans ODR-10, which is a G protein-coupled receptor involved in odorant response 7TM chemoreceptor, str family R02D1.1 R02D1.1 Putative paralog of C. elegans T04A11.2 gene product R02D3.1 R02D3.1 Protein with high similarity to lysine-oxoglutaratereductase/saccharopine dehydrogenase (mouse Lorsdh), which is a bifunctional enzyme of the lysine-degradative pathway that catalyzes conversion of lysine to alpha-aminoadipic semialdehyde dehydrogenase; The R02D3.1 gene encodes an ortholog of the human gene ALPHA-AMINOADIPATE SEMIALDEHYDE SYNTHASE (AASS; OMIM:605113), which when mutated leads to hyperlysinemia (OMIM:238700). R02D3.2 R02D3.2 Protein with weak similarity to H. sapiens Hs.177410 (Human GAP SH3 binding protein mRNA, complete cds) R02D3.3 R02D3.3 Protein with low similarity to general transcription factor IIH polypeptide 1 62kD subunit (human GTF2H1), which is a part of transcription factor TFIIH involved in transcription initiation and nucleotide excision repair and possibly in Cockayne syndrome R02D3.4 R02D3.4 Protein with strong similarity to D. melanogaster MAT89Ba (ovary2) protein R02D3.5 R02D3.5 Putative prenyltransferase, has strong similarity to human farnesyltransferase, alpha subunit, FNTA (Hs.138381) farnesyltransferase alpha subunit R02D3.6 R02D3.6 Protein of unknown function containing a Ground-like domain, has weak similarity to C. elegans F28A12.2 R02D3.7 R02D3.7 Protein containing three C2H2 type zinc finger domains, which bind nucleic acids R02D3.8 R02D3.8 Member of the exonuclease family, has strong similarity to uncharacterized C. elegans M02B7.2 R02D5.1 R02D5.1 Protein of unknown function R02D5.3 R02D5.3 Protein of unknown function, has weak similarity to C. elegans F01D5.6 R02D5.4 R02D5.4 Protein of unknown function R02D5.6 R02D5.6 Protein with moderate similarity to C. elegans C27H5.6 gene product R02D5.7 R02D5.7 Protein of unknown function, has high similarity to uncharacterized C. elegans C25A8.2 R02E12.2 R02E12.2 Protein of unknown function, has a region of low similarity to S. cerevisiae Hym1p, which is required for sporulation, apical cell growth, and efficient cell separation mouse MO25 protein R02E12.4 R02E12.4 Protein containing a C3HC4 type (RING) zinc finger, which may mediate protein-protein interactions Sea urchin tektin A1 ; trans-acting transcriptional factor R02E12.5 R02E12.5 Protein of unknown function R02E12.6 R02E12.6 Protein of unknown function, has low similarity to uncharacterized C. elegans F36H1.5 R02E12.8 acr-10;R02E12.1;R02E12.8 Protein containing neurotransmitter-gated ion-channel ligand bindingand transmembrane domains, has moderate similarity to C. elegans ACR-16, which is a nicotinic acetylcholine receptor alpha-1 subunit acr-10 encodes an alpha-7-like homomer-forming subunit of the nicotinic acetylcholine receptor (nAChR) superfamily which encode ligand-gated ion channels that regulate fast action of acetylcholine at neuromuscular junctions and in the nervous system; ACR-10 is a member of the ACR-16-like group of nAChR subunits. R02E4.1 R02E4.1 Protein of unknown function R02F11.1 R02F11.1 Protein with strong similarity to C. elegans C43F9.5 gene product R02F11.2 R02F11.2 Protein containing three CX module domains and a C-type lectin domain, which mediate calcium-dependent carbohydrate recognition R02F11.3 R02F11.3 Member of the cation efflux family, which may be membrane divalent cation transporters, has high similarity to uncharacterized C. elegans F56C9.3 R02F11.4 R02F11.4 Protein containing five leucine rich repeats, which mediate protein-protein interactions, has a region of low similarity to a region of adenylate cyclase (S. cerevisiae Cyr1p), which generates cAMP in response to ras activation R02F2.1 R02F2.1 Protein containing two cyclin N-terminal domains R02F2.2 R02F2.2 Protein containing two RhoGEF (GTPase exchange factor) domains, has a region of low similarity to a region of breakpoint cluster region (human BCR), which is a GTPase-activating protein for p21rac with serine/threonine kinase activity R02F2.4 R02F2.4 Protein containing six chitin binding peritrophin-A domains, which contain six conserved cysteines that probably form three disulphide bridges, has a region of low similarity to a region of C. elegans CEJ-1, which is involved in developmental processes R02F2.5 R02F2.5 Protein of unknown function R02F2.6 R02F2.6 Protein of unknown function R02F2.7 R02F2.7 Protein of unknown function R02F2.8 R02F2.8 Member of the transmembrane amino acid transporter (permease) family, has weak similarity to a region of S. cerevisiae Ynl101p, which is involved in vacuolar efflux of the large neutral amino acids glutamine, tyrosine, and isoleucine R02F2.9 R02F2.9 Protein of unknown function R03A10.1 R03A10.1 Protein of unknown function R03A10.2 R03A10.2 Protein of unknown function R03A10.3 R03A10.3 Protein of unknown function R03A10.4 R03A10.4 Member of the aminotransferase (tentative) protein family gluamine-phenylpyruvate transaminase R03A10.5 R03A10.5 Protein of unknown function, has low similarity to uncharacterized C. elegans F20G2.3 R03A10.6 R03A10.6 Member of the rhodopsin family of G protein-coupled receptors (GPCR) steroid hormone receptor R03C1.1 R03C1.1 Interacts with UNC-101 in a large scale two-hybrid assay R03C1.2 R03C1.2 Protein of unknown function R03C1.3 R03C1.3 Protein containing a homeobox domain (homeodomain), which are found in transcription factors, has low similarity to C. elegans CEH-17, which is a homeodomain transcription factor that promotes longitudinal growth of axons in certain neurons Homeobox domain; The cog-1 gene encodes an ortholog of a Nkx6.1/Gtx homeodomain protein that affects connection of uterus to the vulva and vulval cell specification. R03D7.1 R03D7.1 Protein with high similarity to methionine synthase (human MTR), member of the homocysteine S-methyltransferase family, contains B12 (adenosylcobamide) binding, B12 binding, and vitamin B12 dependent methionine synthase activation domains 5-methyltetrahydrofolate-homocysteine methyltransferase; R03D7.1 is orthologous to the human gene METHIONINE SYNTHASE (MTR; OMIM:156570), which when mutated leads to disease. R03D7.2 R03D7.2 Putative ortholog of C. elegans K08D10.5 gene product helicase domain R03D7.4 R03D7.4 Elongin A, stimulator of RNA pol II transcription R03D7.5 R03D7.5 Serine/threonine protein kinase of the glycogen synthase kinase 3 subfamily, has similarity to D. melanogaster SGG (shaggy) protein kinase and human GSK3B protein kinase serine/threonine kinase R03D7.6 R03D7.6 Protein containing glutathione S-transferase N-terminal and C-terminal domains, has moderate similarity to prostaglandin D2 synthase (human PGDS), which is prostaglandin D synthase and glutathione S-transferase that regulates non-rapid eye movement sleep glutathione S-transferase R03D7.7 nos-1;R03D7.7 Protein that functions in development of the germ lineage, has similarity to D. melanogaster nanos nanos protein; nos-1 encodes an putative RNA-binding protein that contains a zinc-binding motif homologous to that of Drosophila Nanos, a posterior-group protein required for embryonic patterning and primordial germ cell development; in C. elegans, NOS-1 is required redundantly with NOS-2, a second Nanos homolog, for maintenance of germ cell viability during postembryonic development and for preventing primordial germ cells from dividing in the absence of food; nos-1 mRNA is expressed dynamically in the embryo, with early expression seen throughout the embryo and later expression restricted solely to germline blastomeres; nos-1 mRNA becomes undetectable after the 200-cell stage, but reappears later at the 550-cell stage; NOS-1 protein is not detectable in germline blastomeres until the 550-cell stage, suggesting that NOS-1 might actually function zygotically in germline specification. R03D7.8 R03D7.8 Member of the serine/threonine protein phosphatase protein family protein phosphatase R03E1.1 R03E1.1 Protein containing six WD domains (WD-40 repeat), which may mediate protein-protein interactions, has a region of low similarity to U5 snRNP-specific 40 kDa protein (human HPRP8BP), which is a U5 snRNP protein that binds to human PRPF8 WD domain, G-beta repeat (3 domains) R03E1.2 R03E1.2 Protein with moderate similarity to C. elegans T14B4.3 gene product R03E1.3 R03E1.3 Protein containing a neurotransmitter-gated ion-channel ligand binding domain and a homeobox domain (homeodomain), has a region of weak similarity to a region of nicotinic acetylcholine receptor alpha-1 subunit (C. elegans ACR-16) Neurotransmitter-gated ion-channel R03E9.1 mdl-1;R03E9.1 Member of the MAD family of putative transcription factors, interacts with C. elegans MAX-1 human Max-interacting bHLH-Zip protein R03E9.2 R03E9.2 Protein of unknown function R03E9.3 R03E9.3 Member of the bicarbonate (HCO3-) exchanger family of membrane transporters, which may be anion exchange or cotransporter proteins, has low similarity to anion exchanger 3 (rat Slc4a3), which is a chloride and bicarbonate exchanger anion exchange protein R03E9.4 irk-1;irk-4;R03E9.4 Member of the 2 TM potassium channel protein family inward rectifier potassium channel (IRK) R03G5.1 R03G5.1 Protein with strong similarity to eukaryotic translation elongation factor 1 alpha 2 (wasted, mouse Eef1a2), which regulates apoptosis in the thymus, contains an elongation factor Tu domain 2, and elongation factor Tu GTP binding and C-terminal domains elongation factor EF-1-alpha; eft-4 encodes a translation elongation factor 1-alpha homolog that is required for embryonic viability, fertility, and a normal postembryonic growth rate; eft-4 encodes at least one alternatively spliced coding sequence identical to that of eft-3. R03G5.2 sek-1;mkk-4;R03G5.2 Serine/threonine protein kinase with strong similarity to human and D. melanogaster MAP kinase kinases (MEK kinases) SER/THR-protein kinase; SEK-1 has MAPKK activity and belongs to the MAPKK family; SEK-1 can activate both JNK-1 and PMK-1 in the yeast Hog pathway. R03G5.3 R03G5.3 Protein containing two DUF41 domains of unknown function R03G5.5 R03G5.5 Member of the glutathione peroxidase family, which catalyze reduction of hydroxyperoxides by glutathione, has moderate similarity to glutathione peroxidase 4 (phospholipid hydroperoxide glutathione peroxidase, mouse Gpx4) glutathione peroxidase R03G5.6 R03G5.6 Protein of unknown function R03G8.1 R03G8.1 Member of uncharacterized DUF229 family, has moderate similarity to uncharacterized C. elegans R03G8.3 R03G8.2 R03G8.2 Protein with strong similarity to C. elegans C49A1.8 gene product reverse transcriptase R03G8.3 R03G8.3 Member of uncharacterized DUF229 family, has high similarity to uncharacterized C. elegans Y73F8A.35 R03G8.4 R03G8.4 Member of the M1 peptidase family of aminopeptidases, has low similarity to a region of leucine aminopeptidase (oxytocinase, rat IRAP), which is an insulin-regulated zinc aminopeptidase zinc metallopeptidase (M1 family) R03G8.5 R03G8.5 Member of the 7-transmembrane chemoreceptor family of G protein-coupled receptors (GPCR), has weak similarity to C. elegans ODR-10, which is a G protein-coupled receptor involved in odorant response R03G8.6 R03G8.6 Member of the M1 peptidase family of aminopeptidases, has low similarity to alanine/arginine aminopeptidase (S. cerevisiae Aap1p) zinc metallopeptidase (M1 family) R03H10.1 R03H10.1 Protein containing an F-box domain, which serve as a link between a target protein and a ubiquitin-conjugating enzyme This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins. R03H10.2 R03H10.2 Putative ortholog of C. elegans R03H10.3 gene product R03H10.4 R03H10.4 Protein containing a DUF130 domain of unknown function, has high similarity to uncharacterized C. elegans R03H10.5 R03H10.5 R03H10.5 Protein containing a DUF130 domain of unknown function, has high similarity to uncharacterized C. elegans R03H10.4 R03H10.6 R03H10.6 Protein containing an OB-fold nucleic acid binding domain, has a region of weak similarity to a region of DNA replication factor A 69kDa subunit (S. cerevisiae Rfa1p), which binds single-stranded DNA R03H10.7 R03H10.7 Putative ortholog of C. elegans R03H10.6 gene product R03H10.8 R03H10.8 Protein of unknown function R03H10.9 R03H10.9 TcA transposase transposase R03H4.1 R03H4.1 Protein containing a DUF33 domain of unknown function, has high similarity to uncharacterized C. elegans R03H4.6 R03H4.2 R03H4.2 Protein of unknown function, has moderate similarity to uncharacterized C. elegans Y49C4A.5 7TM chemoreceptor, srx family R03H4.3 R03H4.3 Protein of unknown function, has moderate similarity to uncharacterized C. elegans Y49C4A.5 7TM chemoreceptor, srx family R03H4.4 R03H4.4 Protein containing a DUF32 domain of unknown function, has high similarity to uncharacterized C. elegans C50H11.10 7TM chemoreceptor, srt family R03H4.5 R03H4.5 Protein containing a DUF33 domain of unknown function, has high similarity to uncharacterized C. elegans Y67A10A.1 R03H4.6 R03H4.6 Protein containing a DUF33 domain of unknown function, has high similarity to uncharacterized C. elegans R03H4.1 R03H4.7 R03H4.7 Protein of unknown function, has high similarity to uncharacterized C. elegans T22G5.4 7TM chemoreceptor, srsx family R03H4.9 R03H4.9 Member of the 7-transmembrane chemoreceptor family of G protein-coupled receptors (GPCR), has high similarity to uncharacterized C. elegans F07C4.13 7TM chemoreceptor, srh family R04A9.1 R04A9.1 Protein of unknown function R04A9.2 R04A9.2 Protein containing a piwi domain and a PAZ (Piwi, Argonaut and Zwille) domain, which may mediate protein-protein interactions, has a region of weak similarity to a region of C. elegans ALG-1, which plays role in the production of small temporal RNA R04A9.3 R04A9.3 Protein of unknown function R04A9.4 ife-2;R04A9.4 Translation initiation factor eIF4E, binds to mRNA cap structure eukaryotic initiation factor 4E (EIF-4E); The ife-2 gene encodes a member of the Initiation Factor 4E (eIF4E) family. R04A9.5 R04A9.5 Protein containing two homeobox domains (homeodomains), a protein kinase domain, and a protein kinase C-terminal domain, has a region of high similarity to a region of ribosomal protein S6 kinase 2 (p70 ribosomal S6 kinase beta, mouse Rps6kb2) R04A9.6 R04A9.6 Protein of unknown function R04B3.1 R04B3.1 Protein with weak similarity to C. elegans R04B3.3 gene product R04B3.2 R04B3.2 Protein with high similarity to aspartylglucosaminidase (N4-(beta-N-acetylglucosaminyl)-L-asparaginase, human AGA), which catalyzes cleavage of amide bonds in N-linked glycoproteins, member of the asparaginase family glycosylasparaginase; The R04B3.2 gene encodes an ortholog of the human gene LYSOSOMAL GLYCOSYLASPARAGINASE (AGA; OMIM:208400), which when mutated leads to aspartylglucosaminuria (OMIM:208400). R04B3.3 R04B3.3 Protein of unknown function, has weak similarity to C. elegans F09B12.1A R04B5.1 R04B5.1 Protein of unknown function R04B5.10 R04B5.10 Member of C. elegans Sra integral membrane protein family, which contain 6-7 hydrophobic, putative transmembrane, regions R04B5.11 R04B5.11 Protein of unknown function R04B5.3 R04B5.3 Protein containing a nuclear hormone receptor C4-type zinc finger domain and a nuclear hormone receptor ligand-binding domain, has weak similarity to C. elegans NHR-80, which is involved in embryogenesis and morphogenesis Zinc finger, C4 type (two domains) R04B5.4 nhr-12;R04B5.4 Member of the nuclear hormone receptor/Zinc finger protein family Zinc finger, C4 type (two domains) R04B5.5 R04B5.5 Member of the alcohol dehydrogenase protein family sorbitol dehydrogenase R04B5.6 R04B5.6 Protein with high similarity to sorbitol dehydrogenase 1 (mouse Sdh1), which is an L-iditol 2-dehydrogenase acting in sorbitol metabolism, member of the zinc-containing alcohol dehydrogenase family sorbitol dehydrogenase R04B5.7 R04B5.7 Protein of unknown function Weak similarity to PAB-dependent poly(A)-specific ribonuclease (Swiss Prot accession number P32521) R04B5.8 R04B5.8 Protein of unknown function, has low similarity to uncharacterized C. elegans F15A2.4 R04B5.9 R04B5.9 Member of the purple acid phosphatase family, contains a UDP-glucoronosyl and UDP-glucosyl transferase domain, has a region of low similarity to UDP-glucuronosyltransferase (rat Udpgtr-2), which acts on testosterone, 4-hydroxybiphenyl and chloramphenicol UDP-glucuronosyltransferase R04D3.1 R04D3.1 Member of the cytochrome P450 family, has low similarity to cytochrome P450 subfamily 2C polypeptide 8 (mephenytoin 4-hydroxylase, human CYP2C8), which is a heme-binding monooxygenase superfamily that metabolizes steroids, fatty acids, and xenobiotics cytochrome P450 R04D3.10 R04D3.10 Member of an uncharacterized protein family R04D3.12 R04D3.12 Protein of unknown function, putative paralog of C. elegans R04D3.6 R04D3.2 R04D3.2 Protein of unknown function, has high similarity to uncharacterized C. elegans R04D3.3 R04D3.3 R04D3.3 Has high similarity to uncharacterized C. elegans R04D3.2 R04D3.4 R04D3.4 Protein of unknown function R04D3.6 R04D3.6 Protein of unknown function, has high similarity to uncharacterized C. elegans R04D3.12 R04D3.7 R04D3.7 Protein of unknown function, has high similarity to uncharacterized C. elegans R04D3.9 R04D3.8 R04D3.8 Protein of unknown function, has moderate similarity to uncharacterized C. elegans F17A2.12 R04D3.9 R04D3.9 Protein of unknown function, has high similarity to uncharacterized C. elegans F17A2.8 R04E5.10 ifd-1;R04E5.10 Member of the intermediate filament family, which are components of the cytoskeleton and nuclear envelope, has high similarity to uncharacterized C. elegans IFD-2 cytoplasmic intermeidate filament protein; ifd-1 encodes two isoforms of a nonessential intermediate filament protein; IFD-1 is predicted to function as a structural component of the cytoskeleton; IFD-1 has no obvious function in RNAi assays. R04E5.2 R04E5.2 Protein containing a DUF21 domain of unknown function, has a region of low similarity to a region of S. cerevisiae Ami3p, which is required for normal mitochondrial structure R04E5.2 encodes a homolog of human ACDP1-ACDP4 and a paralog of C01H6.6, C33D12.2, C52D10.12, M02F4.3, and R13G10.4; both R04E5.2 and ACDP1-ACDP4 belong to a family of proteins (defined by NCBI as KOG2118) that are predicted to be membrane-spanning and that share a motif (the 'ACD domain') with proteins from bacteria, yeast, plants, and metazoa; murine Acdp1 is a plasma membrane protein bacterial proteins containing the ACD domain include CorC from Salmonella typhimurium, which is involved in magnesium and cobalt efflux; R04E5.2 has no obvious function in RNAi assays. R04E5.7 R04E5.7 Protein of unknown function R04E5.8 R04E5.8 Protein with weak similarity to C. elegans T23E7.2 gene product R04E5.9 R04E5.9 Protein of unknown function R04F11.1 R04F11.1 Protein of unknown function, has low similarity to uncharacterized C. elegans C24H10.1 R04F11.1 encodes a claudin homolog that may be required for normal cohesion of apical junctions in epithelia; R04F11.1 is worm-specific, with obvious homologs only in C. elegans; R04F11.1 has no obvious function in mass RNAi assays; claudins are integral membrane proteins with four transmembrane sequences that are found in mammalian tight junctions (TJs), induce TJs when transgenically expressed in cells normally lacking them, and can mediate the specific conductance of of specific ions (e.g., magnesium or calcium) through TJs while blocking the flow of water. R04F11.2 R04F11.2 Protein of unknown function R04F11.3 R04F11.3 Protein with weak similarity to H. sapiens Hs.169504 (Human mRNA for KIAA0170 gene, complete cds) R04F11.4 twk-15;R04F11.4 Member of the 4 TM potassium channel protein family potassium channel protein; twk-13 encodes one of 44 C. elegans TWK (two-P domain K+) potassium channel subunits that contain two pore-forming domains and four transmembrane domains; as loss of TWK-13 function via RNA-mediated interference (RNAi) does not result in any abnormalities, the precise role of TWK-13 in C. elegans development and/or behavior is not yet known; however, TWK-13 likely functions redundantly with other TWK channels; the TWK-13 expression pattern has not been determined. R04F11.5 R04F11.5 Protein with weak similarity to C. elegans R04F11.3 gene product R05A10.1 R05A10.1 Member of the reverse transcriptase protein family, which are RNA-dependent DNA polymerases, has high similarity to uncharacterized C. elegans T19C9.7 R05A10.2 R05A10.2 Protein of unknown function R05A10.3 R05A10.3 Protein of unknown function R05A10.4 R05A10.4 Protein of unknown function, has weak similarity to C. elegans Y45F10C.4 R05A10.5 R05A10.5 Protein of unknown function, has low similarity to uncharacterized C. elegans F58F9.6 R05A10.6 R05A10.6 Protein containing a DUF138 domain of unknown function, has moderate similarity to uncharacterized C. elegans F54D10.8 R05A10.7 R05A10.7 Protein containing two DUF235 domains of unknown function, has high similarity to uncharacterized C. elegans F41D3.9 R05A10.8 R05A10.8 Protein of unknown function, has high similarity to uncharacterized C. elegans K06H6.2 R05C11.C mca-2;R05C11.3;R05C11.C Protein with high similarity to a plasma membrane Ca2+ ATPase type 2 pump (rat Atp2b2), which may affect vestibular hair cell function, member of the E1-E2 (P-type) ATPase and haloacid dehalogenase families, contains an ATPase N- and a C-terminus domain R05D11.1 R05D11.1 Member of the dwarfin family, has low similarity to MAD (mothers against decapentaplegic, Drosophila) homolog 1 (rat Madh1), which is a transcription factor that is phosphorylated and regulated in response to members of the TGF-beta superfamily MAD protein R05D11.3 Ce-ntf2;R05D11.3 Putative nuclear transport factor that has high similarity to H. sapiens NTF2 (nuclear transport factor 2) and appears to be required for embryonic development nuclear transport factor 2 like; ran-4 encodes a ortholog of NUCLEAR TRANSPORT FACTOR 2 (NTF2) from S. cerevisiae and metazoa, which is predicted to interact with nucleoporins and to promote transport of RAN-1(+GDP) into the nucleus; RAN-4/NTF2 proteins are paralogous to the N-terminal domain of RasGAP SH3 binding proteins such as Drosophila RASPUTIN, and to delta-5-3-ketosteroid isomerases, while having no homology to Ran proteins per se; RAN-4 is essential for early embryogenesis; in mass RNAi assays, ran-4 is needed for embryonic viability, normally rapid growth, fertility, and normal pronuclear envelopes in the embryo. R05D11.4 R05D11.4 Member of the DEAD or DEAH box ATP-dependent RNA helicase family and contains a helicase conserved C-terminal domain, has low similarity to S. cerevisiae Rok1p, which is an ATP-dependent RNA helicase required for rRNA processing ATP dependent RNA helicase R05D11.5 R05D11.5 Protein of unknown function R05D11.6 R05D11.6 Protein of unknown function R05D11.7 R05D11.7 Protein of unknown function, has high similarity to uncharacterized putative nucleic acid binding protein RY1 (human RY1) R05D11.8 R05D11.8 Protein of unknown function R05D11.9 R05D11.9 Protein of unknown function R05D3.1 R05D3.1 Member of the ATP-dependent DNA topoisomerase II family, and of the DNA gyrase or topoisomerase IV subunit A family, contains a histidine kinase-like ATPase domain, has moderate similarity to DNA topoisomerase II (S. pombe Top2p) DNA topoisomerase II; This gene encodes a protein predicted by Eisenberg and coworkers, with 52% accuracy, to be mitochondrial. R05D3.11 YNCA;R05D3.11 Protein containing a SET domain, which are involved in protein-protein interactions, and a methyl-CpG binding domain, has a region of weak similarity to a region of S. pombe Clr4p, which is required for mating-type locus and centromeric silencing R05D3.2 R05D3.2 Protein of unknown function R05D3.2 is orthologous to the human gene UNKNOWN (PROTEIN FOR MGC:16889) (C7orf2; OMIM:605522), which when mutated leads to disease. R05D3.3 R05D3.3 Protein with weak similarity to H. sapiens Hs.181409 (Human X2 box repressor mRNA, complete cds) Zinc finger R05D3.4 R05D3.4 Putative coiled-coil protein, contains a C3HC4-type (RING finger) zinc finger domain R05D3.5 R05D3.5 Protein with strong similarity to C. elegans ZC262.1 gene product R05D3.6 R05D3.6 Protein of unknown function, has very strong similarity to uncharacterized C. elegans ZC262.5 ATPase epsilon chain R05D3.7 unc-116;R05D3.7 Member of the kinesin motor domain protein family required for coordinated movement Kinesin heavy chain R05D3.8 R05D3.8 Protein of unknown function R05D3.9 R05D3.9 Putative ortholog of C. elegans R05D3.10 gene product R05D7.1 R05D7.1 Protein of unknown function, has weak similarity to C. elegans F17E9.5 R05D7.2 R05D7.2 Protein of unknown function, has low similarity to uncharacterized C. elegans Y57A10A.H R05D7.3 R05D7.3 Protein of unknown function R05D7.4 R05D7.4 Member of the alpha or beta hydrolase fold family, has moderate similarity to uncharacterized C. elegans F32B4.6 alpha/beta hydrolase fold R05D7.5 R05D7.5 Protein of unknown function R05D8.10 R05D8.10 Putative paralog of C. elegans R05D8.7 alcohol dehydrogenase; dhs-15 encodes a member of the short chain dehydrogenase/reductase family. R05D8.11 R05D8.11 Protein of unknown function, has moderate similarity to C. elegans F43C11.11 R05D8.12 R05D8.12 Putative ortholog of C. elegans R05D8.5 gene product R05D8.2 R05D8.2 Protein of unknown function, putative paralog of C. elegans Y45G12C.14 7TM chemoreceptor, srj family R05D8.3 R05D8.3 Protein of unknown function, putative paralog of C. elegans Y49F6A.2 7TM chemoreceptor, srh family R05D8.4 R05D8.4 Putative paralog of C. elegans C24B9.13 7TM chemoreceptor, srx family R05D8.5 R05D8.5 Protein with strong similarity to C. elegans R13D11.9 7TM chemoreceptor, srx family R05D8.6 R05D8.6 Protein of unknown function, has strong similarity to C. elegans C24B9.7 7TM chemoreceptor, srg family R05D8.7 R05D8.7 Putative paralog of C. elegans F25D1.5 R05D8.8 R05D8.8 Putative paralog of C. elegans R05D8.9 alcohol dehydrogenase; dhs-14 encodes a short chain-type of alcohol/other dehydrogenase, more similar to 18 paralogs in C. elegans than to any non-worm protein; it is dispensable for viability and gross morphology in mass RNAi screens. R05D8.9 R05D8.9 Putative paralog of C. elegans R05D8.8 alcohol dehydrogenase R05D8.A kettin;F54E2.3;F54E2.4;R05D8.A Protein containing many immunoglobulin (Ig) domains, has weak similarity to a region of titin (human TTN), which is a large sarcomeric protein that extends from the I band to the Z disk of sarcomeres and maintains resting tension in muscle R05D8.O F54E2.2;R05D8.O Protein with moderate similarity to C. elegans T28C12.6 gene product R05F9.1 R05F9.1 Protein containing two K+ channel tetramerization domains, which facilitate assembly of alpha-subunits into functional tetrameric channels yeast suppressor protein SRP40 (weak) R05F9.10 R05F9.10 Member of the heat shock/TPR repeat protein family TPR domain repeats R05F9.11 R05F9.11 Protein of unknown function, has moderate similarity to uncharacterized C. elegans Y39E4B.2 A. thaliana ELI3-2 protein R05F9.12 R05F9.12 Putative sucrase-isomaltase, putative ortholog of H. sapiens SI gene product [sucrase-isomaltase] glycosyl hydralase; sucrase-isomaltase R05F9.13 msp-31;R05F9.13 Member of the major sperm protein family major sperm protein; msp-31 encodes a member of the major sperm protein family; expression is enriched in sperm. R05F9.3 msp-32;R05F9.3 Member of the MSP (major sperm protein) domain protein family major sperm protein; msp-32 encodes a protein that belongs to a family of proteins called the Major Sperm Proteins (MSPs) that is conserved in nematodes; this family consists of closely related, small, basic proteins that make up 15% of sperm protein; this multigene family consists of over fifty genes, including many pseudogenes; MSPs are involved in both extracellular signaling and cytoskeletal functions during reproduction-MSP antagonizes Eph/ephrin signaling, in part, by binding VAB-1 Eph receptor tyrosine kinase on oocytes and sheath cells to promote oocyte maturation and MAPK activation; MSPs assemble into fibrous networks that drive movement of the C. elegans sperm; msp genes are expressed only in late primary spermatocytes. R05F9.4 R05F9.4 Member of the reverse transcriptase protein family, which are RNA-dependent DNA polymerases, has very strong similarity to uncharacterized C. elegans Y37E3.18 reverse transcriptase R05F9.5 R05F9.5 Protein containing two glutathione S-transferase N-terminal domains and two glutathione S-transferase C-terminal domains, has low similarity to human PGDS, which is a prostaglandin D2 synthase and glutathione S-transferase glutathione S-transferase; gst-9 encodes a predicted glutathione S-transferase; by homology, GST-9 is predicted to play a role in the detoxification of environmental toxins and xenobiotics by transferring glutathione to reactive electrophilic compounds; however, as loss of gst-9 activity via large-scale RNAi screens does not result in any obvious abnormalities, the precise role of GST-9 in C. elegans development and/or behavior is not yet known. R05F9.6 R05F9.6 Protein with high similarity to phosphoglucomutase 1 (human PGM1), which catalyzes the conversion of glucose 1-phosphate to glucose 6-phosphate, contains phosphoglucomutase/phosphomannomutase alpha-beta-alpha I/II/III and C-terminal domains phosphoglucomutase; This gene encodes a protein predicted by Eisenberg and coworkers, with 68% accuracy, to be mitochondrial. R05F9.7 R05F9.7 G protein-coupled receptor, member of a subfamily with SRE proteins which are expressed in chemosensory neurons, no homolog found in human or D. melanogaster R05F9.8 msp-33;R05F9.8 Member of the major sperm protein family major sperm protein; msp-33 encodes a protein that belongs to a family of proteins called the Major Sperm Proteins (MSPs) that is conserved in nematodes; this family consists of closely related, small, basic proteins that make up 15% of sperm protein; this multigene family consists of over fifty genes, including many pseudogenes; MSPs are involved in both extracellular signaling and cytoskeletal functions during reproduction-MSP antagonizes Eph/ephrin signaling, in part, by binding VAB-1 Eph receptor tyrosine kinase on oocytes and sheath cells to promote oocyte maturation and MAPK activation; MSPs assemble into fibrous networks that drive movement of the C. elegans sperm; msp genes are expressed only in late primary spermatocytes. R05F9.9 R05F9.9 Protein of unknown function, has weak similarity to C. elegans Y38A8.3 R05G6.1 R05G6.1 Protein of unknown function R05G6.10 R05G6.10 Protein containing two ras guanine nucleotide exchange factor (GEF) domains, has weak similarity to a region of S. cerevisiae Cdc25p, which is a guanine-nucleotide exchange protein for S. cerevisiae Ras1p and Ras2p Cell Division control protein R05G6.2 R05G6.2 Member of the transposase family, which are required for excising and inserting mobile genetic elements, has very strong similarity to uncharacterized C. elegans Y95B8A.3 transposase R05G6.3 R05G6.3 Protein of unknown function R05G6.4 R05G6.4 Protein of unknown function, has moderate similarity to uncharacterized human NOSIP R05G6.5 R05G6.5 Protein of unknown function, has similarity to human NME5, a protein abundant in testes and having similarity to nucleoside-diphosphate kinases R05G6.6 R05G6.6 Protein with high similarity to C. elegans GLT-2, which is a glutamate transporter, member of the sodium:dicarboxylate symporter family of membrane transporters Amino Acid Transporter; glt-6 encodes an ortholog of glutamate/aspartate and neutral amino acid transporters. R05G6.7 R05G6.7 Member of the eukaryotic porin family, which are mitochondrial membrane channel proteins, has moderate similarity to voltage-dependent anion channel 2 (mouse Vdac2), which is a voltage-gated pore that may be involved in transport of adenine nucleotides Channel Protein R05G6.8 R05G6.8 Protein containing an EF hand domain, a C2 domain, and phosphatidylinositol-specific phospholipase C X and Y domains, has low similarity to phospholipase C delta 1 (human PLCD1), which hydrolyzes phosphatidylinositol 4,5-bisphosphate to second messengers phospholipase R05G6.9 R05G6.9 Protein containing five epidermal growth factor (EGF)-like domains, has low similarity to a region of notch (Drosophila) homolog 2 (rat Notch2), which is involved in cell fate determination and differentiation of muscle, eye and tooth R05G9.B R05G9.3;R05G9.B Protein of unknown function R05G9.C R05G9.2;R05G9.C Protein with weak similarity to C. elegans twk-20 gene product R05G9.E R05G9.1;R05G9.E Protein of unknown function R05G9R.A R05G9R.1;R05G9R.A Protein of unknown function R05H10.1 R05H10.1 Protein of unknown function, has moderate similarity to uncharacterized C. elegans W02D7.4 R05H10.2 R05H10.2 Protein containing two RNA recognition motifs (RRM, RBD, or RNP), has low similarity to a region of S. cerevisiae Nop4p, which is a nucleolar protein required for ribosome biogenesis RNA recognition motif. (aka RRM, RBD, or RNP domain) (2 domains) R05H10.3 R05H10.3 Putative ortholog of C. elegans Y53F4A.3 gene product R05H10.5 R05H10.5 Protein with high similarity to glutathione peroxidase 4 (phospholipid hydroperoxide glutathione peroxidase, mouse Gpx4), which is a selenoprotein that protects membrane phospholipids against peroxidation, member of the glutathione peroxidase family Glutathione peroxidases R05H10.6 cdh-7;R05H10.6 Protein containing three cadherin domains, which are found in the extracellular domain of some receptors and cell adhesion proteins, has weak similarity to a region of cadherin related 23 (human CDH23), which is associated with Usher syndrome type 1D Cadherin (3 domains); cdh-7 encodes a protein that contains a cadherin domain. R05H11.1 R05H11.1 Protein containing an F-box domain, which serve as a link between a target protein and a ubiquitin-conjugating enzyme, has weak similarity to uncharacterized C. elegans F59B2.9 This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins. R05H5.1 srd-2;R05H5.1 G protein-coupled receptor, member of a subfamily with SRD proteins which are expressed in chemosensory neurons, no homolog found in human or D. melanogaster R05H5.2 R05H5.2 Protein containing a rhodanese-like domain, has a region of moderate similarity to a region of C. elegans K06A5.7, which is involved in cell division M-phase inducer phosphatase; a homolog of dual specificity phosphatase Cdc25. R05H5.3 R05H5.3 Putative nuclear thioredoxin thioredoxin R05H5.4 R05H5.4 Protein containing a Src homology 2 (SH2) domain, which are regulatory modules of intracellular signaling, and a protein kinase domain, has low similarity to fer (fps/fes related) tyrosine kinase (mouse Fert2), which may have roles in cell-cell signaling tyrosine-protein kinase (FES/FPS subfamily) R05H5.5 R05H5.5 Protein of unknown function, has low similarity to uncharacterized human ARV1 R05H5.6 srb-6;R05H5.6 G protein-coupled receptor, expressed in chemosensory neurons, no homolog found in human or D. melanogaster 7TM receptor, srb family R05H5.7 R05H5.7 Protein of unknown function, has weak similarity to C. elegans T28C12.6 R06A10.1 R06A10.1 Protein of unknown function R06A10.2 gsa-1;R06A10.2 G-protein alpha subunit guanine nucleotide-binding protein; The gsa-1 gene encodes a Gs alpha subunit of heterotrimeric G proteins which affects L1 larval stage viability, movement, and egg laying; it is genetically upstream of sgs-1 with respect to neuronal degeneration, as defined by gain-of-function analysis, and is expressed in excitable cells. R06A10.3 R06A10.3 Protein of unknown function R06A10.4 R06A10.4 Serine/threonine protein kinase, has similarity to human, D. melanogaster, and S. cerevisiae calcium/calmodulin-dependent protein kinases protein kinase R06A4.10 R06A4.10 Nicotinic acetylcholine receptor nicotinic acetylcholine receptor; acr-20 encodes an alpha 7-like homomer-forming subunit of the nicotinic acetylcholine receptor (nAChR) superfamily which encode ligand-gated ion channels that regulate fast action of acetylcholine at neuromuscular junctions and in the nervous system; ACR-20 is a member of the DEG-3-like group of nAChR subunits which appears to be unique to nematodes. R06A4.2 R06A4.2 Protein of unknown function, has high similarity to uncharacterized C. elegans T12E12.3 R06A4.3 R06A4.3 Protein of unknown function, has strong similarity to uncharacterized C. elegans Y73B3A.6 transposase R06A4.4 R06A4.4 Protein with high similarity to transportin (karyopherin beta 2, human KPNB2), which is a nuclear pore complex component that mediates human HNRPA1 import via M9 nuclear localization sequence binding and binds nuclear GTP-bound human RAN and human NUP153 importin beta, nuclear transport factor R06A4.6 R06A4.6 Protein of unknown function, has low similarity to uncharacterized C. elegans Y57A10B.6 similar to PES-10 R06A4.7 mes-2;R06A4.7 May regulate chromatin structure SET domain; mes-2 encodes a SET domain-containing protein that is orthologous to the Drosophila Polycomb group protein Enhancer of zeste [E(Z)]; as a member of a Polycomb-like chromatin repressive complex with MES-3 and MES-6, MES-2 is required maternally for normal germline development and during larval development, for anteroposterior patterning; during germline development, the MES-2/MES-3/MES-6 complex is believed to be essential for maintaining repression of the X chromosome, and in transgenic animals, the complex is necessary for germline repression of repetitive transgenes; in axial patterning, the MES-2/MES-3/MES-6 complex is required in somatic tissues for maintaining homeotic gene repression, acting upstream of the Hox genes lin-39, mab-5, and egl-5, as well as the egl-5 target gene lin-32; in addition, MES-2 activity is required for normal levels and localization of MES-3 in >24-cell-stage embryos; MES-2 expression is detected in the primordial germ cells and germline nuclei throughout development, in all nuclei in early embryos, and in somatic nuclei, including those of the male tail, in L2 and L3 larvae; in the nucleus, MES-2 appears to localize to chromatin. R06A4.8 R06A4.8 Protein with moderate similarity to glycogen debranching enzyme (amylo-1,6-glucosidase 4-alpha-glucanotransferase, human AGL), which acts as a glycantransferase and glucosidase in glycogen degradation and is implicated in type III glycogen storage disease Alpha amylase; R06A4.8 is orthologous to the human gene GLYCOGEN DEBRANCHING ENZYME ISOFORM 6 (AGL; OMIM:232400), which when mutated leads to glycogen storage disease, type III. R06A4.9 R06A4.9 Protein of unknown function, contains six WD40 Repeats six WD40 repeats R06B10.1 R06B10.1 Member of the protein-tyrosine phosphatase family and containing a WSN domain of unknown function, has a region of low similarity to a region of C. elegans F10G8.1, which is a putative tyrosine protein phosphatase involved in embryogenesis protein-tyrosine phosphatase R06B10.2 R06B10.2 Member of the protein-tyrosine phosphatase family, which are involved in control of cell growth, proliferation, and differentiation, contains a WSN domain of unknown function, has moderate similarity to uncharacterized C. elegans C08G5.1 R06B10.4 R06B10.4 Putative paralog of C. elegans ZC21.2 (Member of the ank repeat protein family) ion transport protein R06B10.5 R06B10.5 Putative ortholog of H. sapiens Hs.8003 R06B9.1 R06B9.1 Protein of unknown function, has a region of weak similarity to a region of vitamin D-3 upregulated protein-1 (human TXNIP), which binds to and inhibits thioredoxin activity and may thus contribute to cellular redox mechanisms in myeloid differentiation dihydroxyvitamin D3-induced protein R06B9.2 R06B9.2 Protein with strong similarity to C. elegans R06B9.3 gene product dihydroxyvitamin D3-induced protein R06B9.3 R06B9.3 Protein of unknown function, has a region of low similarity to a region of vitamin D-3 upregulated protein-1 (mouse Txnip), which is induced by oxidative stress and functions as an oxidative stress mediator by binding and inhibiting thioredoxin activity R06B9.4 R06B9.4 Protein of unknown function, has low similarity to uncharacterized C. elegans R06B9.3 dihydroxyvitamin D3-induced protein R06B9.5 R06B9.5 Protein of unknown function R06C1.1 hda-3;R06C1.1 Protein with high similarity to histone deacetylase 1 (mouse Hdac1), which is a protein deacetylase and transcriptional corepressor that controls proliferation and differentiation through histone deacetylation, member of the histone deacetylase family Histone deacetylase family; hda-3 encodes a member of the histone deacetylase family most similar to human histone deacetylase 1 (HD1) that affects radiation sensitivity. R06C1.2 R06C1.2 Member of the polyprenyl synthetase family, which function in isoprenoid biosynthesis, has low similarity to farnesyl diphosphate synthetase (rat Fdps), which catalyzes the synthesis of farnesyl pyrophosphate during cholesterol biosynthesis Polyprenyl synthetases R06C1.3 R06C1.3;CeSCAR Protein containing a Wiskott Aldrich syndrome homology region 2 (WH2) domain, has low similarity to WAS protein family member 3 (human WASF3), which associates with and may regulate the Arp2-Arp3 complex involved in regulating the actin cytoskeleton wve-1 encodes a homolog of the mammalian WAVE protein; based on homology WVE-1 might be involved in actin cytoskeletal dynamics; wve-1 is required for early cell migrations in the epidermis during embryonic morphogenesis and may require gex-2 and gex-3 for its function. R06C1.4 R06C1.4 Protein containing an RNA recognition motif (RRM, RBD, or RNP), has high similarity to a region of cleavage stimulation factor subunit 2 tau (mouse Cstf2t), which is a variant of mouse Cstf2 and is part of a complex that functions in RNA processing RNA recognition motif. (aka RRM, RBD, or RNP domain) R06C1.6 R06C1.6 Protein with moderate similarity to C. elegans Y32G9A.B gene product R06C7.1 R06C7.1 Protein containing a piwi domain and a PAZ (Piwi, Argonaut and Zwille) domain, which may mediate protein-protein interactions, has a region of weak similarity to a region of C. elegans ALG-1, which plays role in the production of small temporal RNA R06C7.10 myo-1;mhc-d;let-75;Myosin;R06C7.10 Protein with high similarity to sarcomeric myosin heavy chain (C. elegans UNC-54), which is a component of thick filaments in muscle, contains a myosin head domain, a myosin N-terminal SH3-like domain, and a coiled-coil myosin heavy chain tail region myosin heavy chain; let-75 encodes a pharynx-specific type II myosin heavy chain (MHC D); LET-75 is required for pharyngeal muscle contraction and thus for normal feeding behavior and post-embryonic development; in vitro, the LET-75 tail domain interacts with ITR-1, an IP3 receptor, and this interaction has been proposed to mediate, in vivo, increased pharnygeal pumping in response to food; LET-75 is expressed exclusively in pharyngeal muscle. R06C7.2 R06C7.2 Protein with moderate similarity to C. elegans Y110A7A.B gene product R06C7.3 dhp-1;CeCRMP;UlipB;R06C7.3 Putative dihydropyrimidinase; strongly similar to human DPYS and related genes; putative paralog of C. elegans UNC-33 dihydropyrimidinase; The R06C7.3 gene encodes a homolog of the human gene DPYS, which when mutated leads to dihydropyrimidinuria (OMIM:222748). R06C7.4 R06C7.4 Protein with strong similarity to C. elegans Y94H6A_148.S gene product R06C7.5 R06C7.5 Protein with high similarity to adenylosuccinate lyase (human ADSL), which catalyzes two steps in adenosine monophosphate biosynthesis and is associated with psychomotor retardation, epilepsy, and autism, member of the fumarate lyase family adenylosuccinate lyase; The R06C7.5 gene encodes an ortholog of the human gene ADSL, which when mutated leads to adenylosuccinate lyase deficiency (OMIM:103050). R06C7.6 R06C7.6 Protein of unknown function, has moderate similarity to uncharacterized human FLJ10204 R06C7.7 R06C7.7 Protein containing three mbt repeat domains, which are found in some nuclear proteins, has moderate similarity to uncharacterized C. elegans Y48G1A.6 lin-61 encodes a protein that contains mbt repeats and has similarity to the Drosophila Polycomb group protein Sex Comb on Midleg and human protein H-l-(3)mbl-like; by homology, LIN-61 is predicted to function as part of a transcriptional regulatory complex that may play a role in transcriptional repression during development; loss of lin-61 activity via RNAi and forward mutations indicates that LIN-61 is required for embryogenesis, genome stability in the soma and the germline, and postembryonic developmental processes including vulval development, in which lin-61 acts as a class B synthetic multivulval (SynMuv) gene. R06C7.8 R06C7.8;CeBub1 Protein required for meiotic progression in the germline; has strong similarity to S. cerevisiae Bub1p, a serine/threonine protein kinase required for cell cycle arrest in response to loss of microtubule function Eukaryotic protein kinase domain; bub-1 encodes a serine/threonine kinase orthologous to Saccharomyces cerevisiae BUB1 which is required for proper function of the mitotic spindle assembly checkpoint and human BUB1 (OMIM:602452) which is mutated in some colorectal cancers; BUB-1 activity is required at several stages of development, including embryogenesis; BUB-1 is expressed predominantly in the anterior of the embryo and in hypodermal seam cells during the L1 and L2 larval stages. R06C7.9 R06C7.9 Protein containing ten C2H2 type zinc finger domains, which bind nucleic acids, has weak similarity to zinc finger protein 255 (human ZNF255), which is a Kruppel-like protein that positively regulates transcription Zinc finger, C2H2 type (5 domains) R06F6.1 cdl-1;R06F6.1 Stem-loop binding protein involved in the regulation of core histone expression cdl-1 encodes a homolog of human hairpin (stem-loop) binding proteins (HBP/SLBP) that bind to the hairpin (stem-loop) structure in the 3' untranslated region (3' UTR) of histone mRNAs, and thus promote histone pre-mRNA processing and translation of mature histone mRNA; CDL-1 is required for normally high levels of histone gene expression, normal cell division during late larval development, embryonic viability, normal vulval morphogenesis, normally rapid apoptosis, and fertility; CDL-1 binds to the stem-loop structure in the 3' UTR of core-histone mRNA; the cdl-1 promoter is most active in dividing cells during embryogenesis and postembryonic development; both CDL-1 and human HBP contain a minimal RNA-binding domain (RBD) of roughly 73 amino acids that has no similarity with other known RNA-binding motifs. R06F6.11 R06F6.11 Protein of unknown function R06F6.2 R06F6.2 Protein containing one clathrin and vacuolar protein sorting-associated (VPS) protein 7-fold repeat domain, has low similarity to uncharacterized human VPS11 vacuolar biogenesis protein (pep5) R06F6.4 R06F6.4 Protein containing an MYND finger domain, has weak similarity to uncharacterized C. elegans F33H2.7 R06F6.5 R06F6.5 Protein of unknown function, has weak similarity to C. elegans T24B8.4 R06F6.6 R06F6.6 Protein containing a homeobox domain (homeodomain), which are found in transcription factors, has a region of moderate similarity to a region of gastrulation brain homeo box 2 (human GBX2), which is a putative transcription factor Homeobox domain R06F6.7 R06F6.7 Protein of unknown function R06F6.8 R06F6.8 Putative ortholog of C. elegans R06F6.8 gene product R06F6.9 R06F6.9 Protein with high similarity to peroxisomal D3,D2-enoyl-CoA isomerase (human PECI), which catalyzes a step in the beta oxidation of fatty acids, member of the enoyl-CoA hydratase or isomerase family, contains an acyl CoA binding domain enoyl CoA hydratase/isomerase R07A4.1 egl-36;shw-2;nShaw2;R07A4.1 Member of the voltage-gated potassium channel protein family potassium channel protein; egl-36 encodes a shaw voltage-gated potassium channel that affects egg laying and defecation; expressed in the uterine, vulval, anal depressor, sphincter, and four anterior head muscles muscles, and in the AVL and DVB neurons. R07A4.2 R07A4.2;egl-36 Protein of unknown function R07A4.3 R07A4.3 Protein of unknown function R07A4.4 R07A4.4 Protein containing two PAN domains, which may mediate protein-protein or protein-carbohydrate interactions R07B1.1 msx1;VAB-15;R07B1.1 Homeodomain transcription factor; similar over the homeodomain to many human and D. melanogaster homeodomain transcription factors homeobox protein (msh subfamily); The vab-15 gene encodes a msh-like homeobox gene that appears required for production of touch cell precursors, and that is orthologous to the human gene MSH HOMEO BOX HOMOLOG 1 (MSX1; OMIM:142983) which when mutated leads to disease. R07B1.10 lec-8;R07B1.10 Member of the galectin family, which are lectins that bind beta galactosides, has low similarity to a region of galectin 8 (rat Lgals8), which interacts with integrins to modulate cell adhesion, migration and apoptosis galaptin domain R07B1.2 lec-7;R07B1.2 Member of the galectin family, which are lectins that bind beta galactosides, has low similarity to a region of lectin galactoside-binding soluble 9 (galectin 9, human LGALS9), which is involved in cell adhesion and chemoattraction galaptin domain R07B1.3 R07B1.3 Member of the CD36 family of putative scavenger receptors, has weak similarity to scavenger receptor BI (rat Cd36l1), which mediates the selective uptake of cholesterol from high density lipoprotein membrane glycoprotein R07B1.4 R07B1.4 Protein containing glutathione S-transferase N-terminal and C-terminal domains, has low similarity to prostaglandin D2 synthase (human PGDS), which is a prostaglandin D synthase and glutathione S-transferase that regulates non-rapid eye movement sleep glutathione S-transferase R07B1.5 R07B1.5 Protein containing one C. elegans C-terminal C6 domain, which contain conserved cysteine residues, has high similarity to uncharacterized C. elegans R07B1.6 R07B1.6 R07B1.6 Protein containing one C. elegans C-terminal C6 domain, which contain conserved cysteine residues, has high similarity to uncharacterized C. elegans R07B1.5 R07B1.7 R07B1.7 Protein of unknown function R07B1.8 R07B1.8 Protein with weak similarity to C. elegans rab-8 gene product GTP binding protein R07B1.9 R07B1.9 Protein of unknown function R07B5.3 R07B5.3 Protein containing a DUF215 domain of unknown function, has low similarity to uncharacterized C. elegans C50C10.1 R07B5.4 R07B5.4 Protein containing a DUF215 domain of unknown function, has high similarity to uncharacterized C. elegans C50C10.1 R07B5.5 R07B5.5 Protein of unknown function, has low similarity to uncharacterized C. elegans Y97E10B.2 R07B5.6 R07B5.6 Protein containing a DUF215 domain of unknown function, has high similarity to uncharacterized C. elegans C33D9.4 R07B5.7 R07B5.7 Protein containing a DUF215 domain of unknown function, has low similarity to uncharacterized C. elegans C38C3.2 R07B5.8 R07B5.8 Protein with similarity to S. cerevisiae Sas3p, which has a role in silencing of transcription zinc finger protein; The R07B5.8 gene encodes a MYST acetyltransferase homologous to the S. cerevisiae SAS3 protein; it is also more distantly homologous to the human MOZ and MORF proteins, which share a similar domain organization C-terminal to the MYST domain. R07B7.1 clh-6;R07B7.1 Putative chloride channel, possible ortholog of human chloride channel 7, CLCN7 (Hs.80768) chloride channel; clh-6 encodes a voltage-gated chloride channel orthologous to the human CLCN7 chloride channel (OMIM:602727, which when mutated lead to osteopetrosis); although the precise role of CLH-6 in C. elegans development and/or behavior is not yet known, CLH-6 expression is detected in two GABA-ergic neurons, RMEL and RMER, suggesting that CLH-6 could play a role in membrane excitability and/or GABA packaging; as CLH-6 is also detected in many non-neuronal tissues, such as the gut and body wall muscle, it could also have a broader role in such as processes as transepithelial transport and muscle excitation. R07B7.10 R07B7.10 Member of the mitochondrial carrier protein family of membrane transporters, has low similarity to solute carrier family 25 member 20 (carnitine-acylcarnitine translocase, rat Slc25a20), which is a mitochondrial carnitine transporter mitochondrial carrier protein R07B7.11 R07B7.11 Member of the melibiase family of O-glycosyl hydrolases, has moderate similarity to alpha-galactosidase A (alpha-D-galactoside galactohydrolase, mouse Gla), which hydrolyses glycosphingolipids to release alpha-D-galactosyl residues alpha-N-acetylgalactosaminidase; R07B7.11 is orthologous to the human gene ALPHA-GALACTOSIDASE B (GALB; OMIM:104170), which when mutated leads to Schindler disease, Kanzaki disease, or NAGA deficiency. R07B7.12 R07B7.12 Protein containing a DUF23 domain of unknown function, has moderate similarity to uncharacterized C. elegans ZK381.2 R07B7.13 R07B7.13 Protein containing a nuclear hormone receptor C4-type zinc finger domain, which bind DNA, and a nuclear hormone receptor ligand-binding domain, has low similarity to nuclear receptor subfamily 1 (group H member 3, mouse Nr1h3) nuclear hormone receptor R07B7.14 R07B7.14 Protein containing nuclear hormone receptor C4-type zinc finger and ligand-binding domains, has low similarity to nuclear receptor subfamily 1 (group H member 3) (mouse Nr1h3), which functions in cholesterol, fatty acid, and bile metabolism nuclear hormone receptor R07B7.15 R07B7.15 Protein containing a nuclear hormone receptor C4-type zinc finger domain and two ligand-binding domains, has low similarity to a region of nuclear receptor subfamily 1 group H member 3 (mouse Nr1h3), which is a nuclear receptor transcription factor Zinc finger, C4 type (two domains) R07B7.16 R07B7.16 Protein containing two nuclear hormone receptor C4-type zinc finger domains, which bind DNA, and a nuclear hormone receptor ligand-binding domain, has low similarity to nuclear receptor subfamily 1 (group H member 3, human NR1H3) nuclear hormone receptor R07B7.2 R07B7.2 Protein of unknown function R07B7.3 R07B7.3 Protein of unknown function The protein product of this gene is predicted to contain a glutamine/asparagine (Q/N)-rich ('prion') domain, by the algorithm of Michelitsch and Weissman (as of the WS77 release of WormBase, i.e., in wormpep77). R07B7.4 R07B7.4 Member of the flavoprotein monooxygenase family of aromatic ring hydroxylases, has low similarity to kynurenine 3-monooxygenase (human KMO), which is a mitochondrial flavoenzyme that hydroxylates kynurenine to 3-hydroxykynurenine in tryptophan catabolism Monooxygenase R07B7.5 R07B7.5 Protein with high similarity to kynurenine 3-monooxygenase (human KMO), which catalyzes kynurenine hydroxylation and is associated with pellagra and colitis, member of the flavoprotein monooxygenase family of aromatic ring hydroxylases Monooxygenase R07B7.6 R07B7.6 Member of the core-2 or I-branching enzyme family, which form blood group I-antigens or side-chains of O-glycans, has weak similarity to human GCNT3, which forms O-glycan branches of the core 2, core 4, and I type and plays a role in O-glycan synthesis acetylglucosaminyltransferase-like domain R07B7.7 R07B7.7 Protein of unknown function R07B7.8 R07B7.8 Member of the phospholipase protein family phospholipase R07B7.9 R07B7.9 Member of the phospholipase protein family phospholipase R07C12.1 R07C12.1 Protein of unknown function, has high similarity to uncharacterized C. elegans K08D10.10 R07C12.2 R07C12.2 Protein of unknown function, has high similarity to uncharacterized C. elegans R07C12.1 R07C12.3 R07C12.3 Protein of unknown function, has high similarity to uncharacterized C. elegans R07C12.1 R07C12.4 R07C12.4 Putative ortholog of C. elegans K08D10.10 gene product R07C3.1 R07C3.1 Member of the C-type lectin protein family R07C3.10 R07C3.10 Protein of unknown function, has low similarity to uncharacterized C. elegans F58E1.12 R07C3.11 R07C3.11 Protein of unknown function, has low similarity to uncharacterized C. elegans F58E1.11 R07C3.12 R07C3.12 Member of the C-type lectin protein family R07C3.13 R07C3.13 Protein of unknown function, has weak similarity to C. elegans F46F5.15 R07C3.14 R07C3.14 Protein of unknown function, has high similarity to uncharacterized C. elegans R07C3.5 R07C3.2 R07C3.2 Protein of unknown function, has low similarity to uncharacterized C. elegans F45D11.10 R07C3.3 R07C3.3 Member of the core-2 or I-branching enzyme family, which form blood group I-antigens or side-chains of O-glycans, has low similarity to human GCNT3, which forms O-glycan branches of the core 2, core 4, and I type and plays a role in O-glycan synthesis R07C3.4 R07C3.4 Member of the AMP-binding enzyme family, has moderate similarity to acyl-CoA synthetase 5 (human FACL5), which catalyzes the synthesis of acyl-CoA from fatty acids, ATP, and CoA ATP-dependent AMP-binding protein R07C3.5 R07C3.5 Protein of unknown function, has high similarity to uncharacterized C. elegans R07C3.14 R07C3.6 R07C3.6 Protein of unknown function, has low similarity to uncharacterized C. elegans C32B5.10 R07C3.7 R07C3.7 Protein of unknown function, has low similarity to uncharacterized C. elegans C44C8.2 R07C3.8 R07C3.8 Protein of unknown function, has high similarity to uncharacterized C. elegans C32B5.10 R07C3.9 R07C3.9 Protein containing an F-box domain, which serve as a link between a target protein and a ubiquitin-conjugating enzyme, has moderate similarity to uncharacterized C. elegans R07C3.8 R07D5.1 unc-7;unc-12;R07D5.1 Member of the OPUS/innexin protein family required in motor neurons for coordinated locomotion unc-7 membrane protein; unc-7 encodes an innexin required for gap junction formation in invertebrates; UNC-7 is also required for normal locomotion, egg-laying, inhibition of feeding by tapping, avermectin sensitivity, and ivermectin sensitivity, as well as for the antagonism of UNC-79 and UNC-80 activity by volatile anesthetics; unc-7 is genetically required, and transcribed in, neurons rather than muscle cells, from larval stages L1 through L4; homologs of UNC-7 include Drosophila OGRE and SHAKING-B, as well as 24 C. elegans paralogs (including EAT-5, UNC-9, and INX-1 through INX-20); UNC-7 genetically interacts with UNC-124, and unc-7 mutants are phenotypically similar to unc-9 and unc-124 mutants; UNC-7 genetically interacts with AVR-14 and GLC-1 in the response to ivermectin. R07D5.2 R07D5.2 Protein of unknown function R07E3.1 R07E3.1 Member of the papain family of cysteine proteases, has low similarity to cathepsin H (rat Ctsh), which is a cysteine (thiol) protease cysteine proteinase R07E3.2 R07E3.2 Protein of unknown function R07E3.3 R07E3.3 Protein of unknown function, has a region of high similarity to a region of C. elegans CUT-1, which is a cuticulin component cuticulin R07E3.4 R07E3.4 Protein with high similarity to solute carrier family 25 member 4 (mouse Slc25a4), which is anadenine nucleotide transporter that functions in metabolism and apoptosis, member of the mitochondrial carrier protein family of membrane transporters ADP,ATP carrier protein R07E3.5 R07E3.5 Member of the phospholipid and glycerol acyltransferase family, which are involved in phospholipid biosynthesis, has moderate similarity to uncharacterized C. elegans F49H12.6 R07E3.6 R07E3.6 Protein of unknown function, has weak similarity to H. sapiens KIAA0170 protein (Hs.169504), has similarity over the C-terminus to D. melanogaster calcium-binding protein CPN R07E3.7 R07E3.7 Protein of unknown function R07E4.1 R07E4.1 Protein of unknown function R07E4.2 R07E4.2 Protein containing a fibronectin type III domain, which are involved in cell surface binding R07E4.3 R07E4.3 Member of the UcrQ ubiquinol-cytochrome C reductase family, has strong similarity to uncharacterized C. elegans F45H10.2 R07E4.4 R07E4.4 Putative uridine diphosphatase, member of the GDA1/CD39 (nucleoside phosphatase) protein family guanosine-diphosphatase R07E4.5 R07E4.5 Protein of unknown function R07E4.6 kin-2;R07E4.6 Regulatory subunit of cAMP-dependent protein kinase that binds KAP-1 kin-2 encodes a predicted regulatory subunit of a cAMP-dependent protein kinase that may act downstream of, or in parallel to, ric-8. R07E5.1 R07E5.1 Protein containing a G-patch domain, which are found in RNA processing proteins R07E5.10 R07E5.10 Protein containing an MYND finger domain, has moderate similarity to uncharactrized mouse Pdcd2 Apoptosis protein RP-8; This gene encodes a homolog of mammalian PROGRAMMED CELL DEATH 2 (PDCD2). R07E5.11 R07E5.11 Protein of unknown function R07E5.12 R07E5.12 Protein of unknown function R07E5.13 R07E5.13 Protein of unknown function, has moderate similarity to uncharacterized S. cerevisiae Ygl080p This gene encodes a homolog of mammalian BRAIN PROTEIN 44-LIKE (BRP44L). R07E5.14 R07E5.14 Protein with high similarity to RNA binding motif protein 8A (human RBM8A), which is an RNA-binding protein that associates with mRNA produced by splicing, contains an RNA recognition motif (RRM, RBD, or RNP) RNA binding domain; rnp-4 encodes a putative member of the exon-exon junction complex, orthologous to Y14 in S. cerevisiae and TSUNAGI in D. melanogaster; RNP-4 is required for embryonic viability, fertility, vulval development, and cuticular integrity; however, rnp-4(RNAi) animals show no accumulation of poly(A)+ mRNA in their nuclei, indicating that RNP-4 is dispensable for mRNA export. R07E5.15 R07E5.15 Protein of unknown function, has strong similarity to uncharacterized C. elegans T23F11.2 R07E5.2 R07E5.2 Member of the thiol antioxidant (thioredoxin peroxidase) protein family Mer5 (mouse) R07E5.3 R07E5.3 Putative component of SWI/SNF-related chromatin remodeling complex; possible ortholog of human matrix associated; actin dependent regulator of chromatin SMARCB1 Snf5 (yeast); The R07E5.3 gene encodes a homolog of SNF5/Ini1, a component of the SWI/SNF complex that is conserved from yeast to mammals and that is involved in chromatin remodeling; R07E5.3 may be involved in asymmetric cell division of the T cells. R07E5.4 R07E5.4 Protein with weak similarity to C. elegans C02D5.2 Glutaredoxin R07E5.5 R07E5.5 Protein containing a C2H2 type zinc finger domain, which bind nucleic acids Zinc finger, C2H2 type R07E5.6 R07E5.6 Protein with weak similarity to C. elegans F54D5.14 (Putative coiled-coil protein, has strong similarity to S. cerevisiae Rhc18p, involved in recombinational DNA repair) Coiled-coil protein R07E5.7 R07E5.7 Protein of unknown function R07E5.8 R07E5.8;CeKu80 Protein containing a KU domain, which bind DNA, has weak similarity to ku 80 (human XRCC5), which is the large subunit of the Ku autoantigen that binds free ends of double-stranded DNA and is involved in DNA repair and V(D)J recombination cku-80 encodes an ortholog of the mammalian XRCC5 gene (also known as Ku autoantigen, 80kD; OMIM:194364), whose product is a subunit of ATP-dependent DNA helicase II and promotes repair by the nonhomologous end-joining pathway; RNA interference of cku-80 results in increased life span though the mechanism seems to be unrelated to nonhomologous end-joining or telomere maintenance; cku-80 is at least superficially dispensable for viability and gross morphology in RNAi assays. R07G3.1 cdc-42;CDC42;R07G3.1 GTP-binding protein of the rho family (ras superfamily); putative ortholog of S. cerevisiae Cdc42p; acts with PAK-1 to mediate hypodermal cell shape changes during embryonic elongation RAS protein; The cdc-42 gene encodes a RHO GTPase which controls polarity of both individual cells and developing embryos by regulating the localization of PAR proteins; it is expressed at hypodermal cell boundaries. R07G3.2 R07G3.2 Member of the class 2 lipase family, has moderate similarity to oncharacterized C. elegans C09E8.2 Lipase R07G3.3 R07G3.3 Coiled-coil protein with strong similarity to human and D. melanogaster TPR proteins, nuclear pore-associated proteins involved in humans in activation of oncogenic kinases myosin heavy chain R07G3.5 R07G3.5 Member of the phosphoglycerate mutase family R07G3.6 R07G3.6 Protein of unknown function R07G3.7 R07G3.7 Protein of unknown function R07G3.8 R07G3.8 Protein of unknown function, has moderate similarity to uncharacterized human DKFZP566A1524 R07H5.1 R07H5.1 Protein with weak similarity to human peroxisomal biogenesis factor PEX14 R07H5.10 R07H5.10 Protein with weak similarity to H. sapiens Hs.79334 (Human bZIP protein NF-IL3A (IL3BP1) mRNA, complete cds) R07H5.2 R07H5.2 Protein with high similarity to carnitine palmitoyltransferase II (human CPT2), which is a mitochondrial long-chain fatty acid oxidation enzyme, member of the choline or carnitine o-acyltransferase family carnitine palmitoyltransferase II; R07H5.2 is orthologous to the human gene CARNITINE PALMITOYLTRANSFERASE II (CPT2; OMIM:600650), which when mutated leads to disease. R07H5.3 R07H5.3 Protein of unknown function R07H5.4 R07H5.4 Protein of unknown function R07H5.5 R07H5.5 Member of the transposase family, which are required for excising and inserting mobile genetic elements, has very strong similarity to uncharacterized C. elegans F11D11.9 transposase R07H5.6 R07H5.6 Protein of unknown function, has strong similarity to uncharacterized C. elegans T07G12.7 Tc5 transposase R07H5.7 R07H5.7 Protein of unknown function, has moderate similarity to uncharacterized C. elegans T27E9.8 R07H5.8 R07H5.8 Protein with strong similarity to adenosine kinase adenosine kinase R07H5.9 R07H5.9 Protein of unknown function, has weak similarity to C. elegans T10B11.4 R08A2.1 R08A2.1 Protein of unknown function, putative paralog of C. elegans Y8G1A.1 R08A2.2 R08A2.2 Putative paralog of C. elegans R08C7.8 serine/threonine protein phosphatase R08A2.3 R08A2.3 Protein of unknown function, has strong similarity to C. elegans ZK1225.6 R08A2.4 R08A2.4 Protein of unknown function, has weak similarity to C. elegans C38D9.4 This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins; this gene's encoded protein also contains an FTH/DUF38 motif, which may also mediate protein-protein interaction. R08A2.5 R08A2.5 Protein of unknown function R08B4.1 grd-1;R08B4.1 Protein of the hedgehog-like family containing four Ground domains and one Hog domain, putative paralog of C. elegans GRD-2 protein groundhog; grd-1 encodes a protein that contains a Hog domain (has similarity to Hedgehog) and a novel Ground domain that is closely related to GRD-2 and GRD-11; expressed in the rectal cells of larvae and adults. R08B4.2 R08B4.2 Protein containing a homeobox domain (homeodomain), which are found in transcription factors, has a region of high similarity to a region of aristaless-like homeobox 4 (mouse Alx4), which is a potent transcription activator homeobox protein (otd subfamily); R08B4.2 is orthologous to the human gene ARISTALESS-RELATED HOMEOBOX, X-LINKED (ARX; OMIM:300382), which when mutated leads to West syndrome (OMIM:308350). R08B4.3 R08B4.3 Protein of unknown function R08C7.1 R08C7.1 Protein of unknown function R08C7.10 R08C7.10 Protein of unknown function R08C7.11 R08C7.11 Protein of unknown function R08C7.12 R08C7.12 Putative ortholog of C. elegans 4F223 gene product R08C7.2 R08C7.2 Member of the Cdc50p-like protein family R08C7.3 R08C7.3 Protein with high similarity to histone H2A variant (S. pombe Pht1p), member of the histone family of nucleosomal core proteins histone H2A variant R08C7.4 R08C7.4 Protein containing a DUF138 domain of unknown function R08C7.5 R08C7.5;icp-2 Protein with weak similarity to C. elegans ICP-1, which is involved in meiosis and cytokinesis R08C7.6 R08C7.6 Protein containing a C-type lectin domain, which mediate calcium-dependent carbohydrate recognition, has high similarity to uncharacterized C. elegans Y25C1A.1 R08C7.7 R08C7.7 Member of the 7-transmembrane chemoreceptor family of G-protein coupled receptors (GPCR), has low similarity to C. elegans ODR-10, which is a G protein-coupled receptor involved in odorant response 7TM chemoreceptor, str family R08C7.8 R08C7.8 Member of the serine/threonine protein phosphatase protein family serine/threonine protein phosphatase R08C7.9 R08C7.9 Protein containing three F-box domains, which serve as a link between a target protein and a ubiquitin-conjugating enzyme, has weak similarity to uncharacterized C. elegans Y20C6A.2 This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins; its encoded protein also contains a Pfam-B45 motif of presently unknown function. R08D7.1 R08D7.1 Protein of unknown function, has low similarity to uncharacterized human MGC13125 R08D7.2 R08D7.2 Protein of unknown function R08D7.3 R08D7.3 Putative eukaryotic translation initiation factor 3 that is expressed in 4 head ganglia late during embryogeneis eif-3. R08D7.4 R08D7.4 Protein of unknown function R08D7.5 R08D7.5 Protein containing two EF hand domains, which are found in signaling, buffering or transport proteins, has low similarity to centrin EF hand protein 2 (caltractin, human CETN2), which is involved in nucleotide excision repair and possibly differentiation caltractin R08D7.6 R08D7.6 Member of the 3'5'-cyclic nucleotide phosphodiesterase protein family, contains a GAF domain, has a region of moderate similarity to a region of cGMP-stimulated phosphodiesterase 2A (human PDE2A), which may play a role in penile erection Cyclic GMP phosphodiesterase R08D7.7 R08D7.7 Protein containing FGGY family of carbohydrate kinases N-terminal and C-terminal domains, has moderate similarity to d-xylulose kinase (A. niger AkiA), which is a xylulokinase Carbohydrate kinase R08E3.1 R08E3.1 Protein with weak similarity to C. elegans lin-12 (Notch family member) LDL receptor-related protein R08E3.2 R08E3.2 Protein with weak similarity to H. sapiens HXB (hexabrachion (tenascin C, cytotactin)) human tenascin-X R08E3.3 R08E3.3 Putative coiled-coil protein, has weak similarity to myosins R08E3.4 R08E3.4 Protein containing six C2H2 type zinc finger domains, has a region of low similarity to a region of S. cerevisiae Pzf1p, which is an RNA polymerase III transcription initiation factor TFIIIA C2H2-type zinc finger R08E5.1 R08E5.1 Putative ortholog of C. elegans R08E5.3 gene product R08E5.2 R08E5.2 Member of the pyridoxal phosphate dependent enzyme beta family, has moderate similarity to a region of cystathionine beta-synthase (rat Cbs), which catalyzes condensation of serine and homocysteine to give cystathionine cysteine synthase R08E5.3 R08E5.3 Member of the ubiE or COQ5 methyltransferase family, has high similarity to uncharacterized C. elegans R08F11.4 R08E5.4 R08E5.4 Protein of unknown function, has high similarity to uncharacterized C. elegans F59A7.2 R08F11.1 R08F11.1 Protein of unknown function, has moderate similarity to uncharacterized C. elegans Y105E8A.10 R08F11.2 R08F11.2 Protein containing a DUF32 domain of unknown function, has high similarity to uncharacterized C. elegans C24B9.5 7TM chemoreceptor, srt family R08F11.3 R08F11.3 Member of the cytochrome P450 family, has moderate similarity to cytochrome P450 subfamily 2J polypeptide 2 (human CYP2J2), which is an arachidonic acid epoxygenase cytochrome P450 R08F11.4 R08F11.4 Member of an uncharacterized protein family R08F11.5 R08F11.5 Protein of unknown function, has moderate similarity to uncharacterized C. elegans H10D18.3 7TM chemoreceptor, srw family R08F11.6 R08F11.6 Member of the transposase family, which mediate transposition of mobile genetic elements, has a region of low similarity to a region of solute carrier family 11 (proton-coupled divalent metal ion transporters) member 3 (ferroportin 1, human SLC11A3) R08F11.7 R08F11.7 Member of the animal heme peroxidase family, which catalyze biosynthetic and degradative reactions using hydrogen peroxide as the electron acceptor, has low similarity to lactoperoxidase (human LPO), which is a milk peroxidase with antimicrobial activity peroxidase R08H2.1 R08H2.1 Member of the alcohol/ribitol dehydrogenase-like protein family dehydrogenase; dhs-23 encodes a short-chain dehydrogenase predicted to be mitochondrial. R08H2.10 R08H2.10 Protein containing a major sperm protein (MSP) domain, which are involved in sperm motility R08H2.11 R08H2.11 Member of the 7-transmembrane chemoreceptor family of G-protein coupled receptors (GPCR), has high similarity to uncharacterized C. elegans F08E10.6 R08H2.12 R08H2.12 Member of the 7-transmembrane chemoreceptor family of G-protein coupled receptors (GPCR), has high similarity to uncharacterized C. elegans R08H2.5 R08H2.13 R08H2.13 Member of the 7-transmembrane chemoreceptor family of G-protein coupled receptors (GPCR), has low similarity to C. elegans ODR-10, which is involved in odorant response 7TM receptor R08H2.2 R08H2.2 Member of the 7-transmembrane chemoreceptor family of G-protein coupled receptors (GPCR), has low similarity to C. elegans ODR-10, which is a G protein-coupled receptor involved in odorant response olfactory receptor ODR-10 like R08H2.3 R08H2.3 Member of the 7-transmembrane chemoreceptor family of G-protein coupled receptors (GPCR), has high similarity to uncharacterized C. elegans Y60A3A.6 G-protein coupled receptor, srh family R08H2.4 R08H2.4 Member of the 7-transmembrane chemoreceptor family of G-protein coupled receptors (GPCR), has high similarity to uncharacterized C. elegans T19C9.3 G-protein coupled receptor, srh family R08H2.5 R08H2.5 Member of the 7-transmembrane chemoreceptor family of G-protein coupled receptors (GPCR), has high similarity to uncharacterized C. elegans R08H2.12 G-protein coupled receptor, srh family R08H2.6 R08H2.6 Member of the 7-transmembrane chemoreceptor family of G-protein coupled receptors (GPCR), has moderate similarity to uncharacterized C. elegans R08H2.11 R08H2.7 R08H2.7 Member of the 7-transmembrane chemoreceptor family of G-protein coupled receptors (GPCR), has low similarity to uncharacterized C. elegans R05D8.3 G-protein coupled receptor, srh family R08H2.8 R08H2.8 Protein of unknown function, has low similarity to uncharacterized C. elegans T19C9.8 R08H2.9 R08H2.9 Protein containing a nuclear hormone receptor C4-type zinc finger domain and two nuclear hormone receptor ligand-binding domains, has moderate similarity to uncharacterized C. elegans ZK1037.5 Zinc finger, C4 type (two domains) R09A1.1 R09A1.1 Protein containing two PAZ (Piwi, Argonaut and Zwille) domains, which may mediate protein-protein interactions, and two piwi domains, has a region of low similarity to a region of Golgi endoplasmic reticulum protein 95 (rat Gerp95) R09A1.2 R09A1.2 Protein containing one BTB (BR-C, ttk and babor) or POZ (Pox virus and zinc finger) domain, which are found in some DNA and actin binding proteins and may mediate protein-protein interactions R09A1.3 R09A1.3 Protein of unknown function R09A1.4 R09A1.4 Protein with strong similarity to C. elegans B0478.2 gene product R09A1.5 R09A1.5 Protein of unknown function R09A8.1 R09A8.1 Putative ortholog of C. elegans T24D5.5 gene product R09A8.2 R09A8.2 Protein of unknown function, has low similarity to uncharacterized C. elegans F02E8.4 R09A8.3 R09A8.3 Protein containing five Kelch motif domains and a BTB or POZ (Pox virus and zinc finger) domain, has weak similarity to kelch-like ECH-associated protein 1 (mouse Keap1), which binds to and inhibits mouse Nfe2l2 translocation to the nucleus ring canal like protein R09A8.4 R09A8.4 Protein containing two collagen triple helix repeats, which are found in some extracellular proteins, has high similarity to a region of collagen type VI, alpha 1 subunit (human COL6A1), which is associated with Bethlem myopathy cuticle collagen R09A8.5 R09A8.5 Protein of unknown function R09B3.1 exo-3;R09B3.1;CeEXOIII Protein with high similarity to apurinic and apyrimidinic endonuclease 1 (rat Apex1), which is a multifunctional DNA repair enzyme that coordinates the repair of abasic sites, member of the apurinic or apyrimidinic (AP) endonuclease family 1 AP endonucleases family 1; exo-3 encodes an ortholog of human APEX/REF1 and rat apurinic/apyrimidinic endonuclease (AP endonuclease 1); EXO-3 is implicated in a DNA damage checkpoint pathway that affects embryonic and larval viability. R09B3.2 R09B3.2 Protein containing an RNA recognition motif (RRM, RBD, or RNP), has high similarity to a region of cleavage stimulation factor subunit 2 tau (mouse Cstf2t), which is a variant of mouse Cstf2 and is part of a complex involved in mRNA processing RNA recognition motif. (aka RRM, RBD, or RNP domain) R09B3.3 R09B3.3 Protein containing an RNA recognition motif (RRM, RBD, or RNP), has high similarity to a region of cleavage stimulation factor subunit 2 tau (mouse Cstf2t), which is an RNA binding protein and a variant of the cleavage stimulation factor 2 (mouse Cstf2) RNA recognition motif. (aka RRM, RBD, or RNP domain) R09B3.4 ubc-12;R09B3.4 Putative NED-8 conjugating enzyme Ubiquitin-conjugating enzymes; The ubc-12 gene encodes a ubiquitin-conjugating enzyme whose substrate is NED-8, and which is required for both embryogenesis and terminal hypodermal differentiation; ubc-12(RNAi) mutants either arrest during embryonic development or show pleotropic defects (e.g., vulval eversion during the L4 stage), as well as defective alae. R09B3.5 mag-1;Ce-mago;R09B3.5 Protein is very similar to D. melanogaster mago, capable of functionally complementing a D. melanogaster point mutation in mago MAGO NASHI PROTEIN R09B5.1 R09B5.1 Protein of unknown function, has strong similarity to C. elegans Y38A10A.4 This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins; this gene's encoded protein also contains an FTH/DUF38 motif, which may also mediate protein-protein interaction. R09B5.10 R09B5.10 Protein of unknown function R09B5.11 R09B5.11 Member of the sugar (and other) transporter family, has moderate similarity to glucose transporter 1 (mouse Slc2a1), which is involved in antiapoptosis and may be involved in carbohydrate metabolism sugar transporter R09B5.12 R09B5.12 Protein with strong similarity to C. elegans C44C1.2 gene product R09B5.2 R09B5.2 Protein of unknown function R09B5.3 R09B5.3 Protein of unknown function R09B5.4 R09B5.4 Protein with weak similarity to solute carrier family 11 (proton-coupled divalent metal ion transporters) member 3 (ferroportin 1) (human SLC11A3), which is a putative iron transporter that shows zinc-inducible expression R09B5.4 is orthologous to the human gene HYPOTHETICAL PROTEIN (SLC11A3; OMIM:604653), which when mutated leads to disease. R09B5.5 R09B5.5 Protein containing nine uncharacterized DUF139 cysteine repeat domains, has strong similarity to uncharacterized C. elegans C03A7.4 The protein product of this gene is predicted to contain a glutamine/asparagine (Q/N)-rich ('prion') domain, by the algorithm of Michelitsch and Weissman (as of the WS77 release of WormBase, i.e., in wormpep77). R09B5.6 R09B5.6 Member of the hydroxyacyl-CoA dehydrogenase protein family 3-hydroxyacyl-CoA dehydrogenase R09B5.7 R09B5.7 Member of the 7-transmembrane chemoreceptor family of G-protein coupled receptors (GPCR), has weak similarity to C. elegans ODR-10, which is involved in odorant response 7TM chemoreceptor, srj family R09B5.8 R09B5.8 Protein of unknown function R09B5.9 R09B5.9 Protein of unknown function R09D1.1 R09D1.1 Member of the glycosyl hydrolase 18 family, has weak similarity to chitinase 3-like 1 (cartilage glycoprotein-39, human CHI3L1), which binds chitin but does not have chitinase activity and is expressed in rheumatoid arthritis cartilage and synovial cells chitinase R09D1.10 R09D1.10 Member of the glycosyl hydrolase 18 family, has low similarity to chitinase 3-like protein 1 (cartilage glycoprotein-39, human CHI3L1), which binds chitin and is expressed in rheumatoid arthritis cartilage and synovial cells chitinase R09D1.11 R09D1.11 Member of the glycosyl hydrolase 18 family, has weak similarity to chitinase 3-like protein 1 (cartilage glycoprotein-39, human CHI3L1), which binds chitin and is expressed in rheumatoid arthritis cartilage and synovial cells chitinase R09D1.12 R09D1.12 Protein containing a protein kinase domain, has moderate similarity to C. elegans OLD-1, which is a putative receptor tyrosine protein kinase thar extends lifespan upon overproduction tyrosine-protein kinase (KIN15/KIN16 subfamily) R09D1.13 R09D1.13 Protein containing a protein kinase domain, has moderate similarity to C. elegans KIN-15, which is a putative receptor tyrosine protein kinase tyrosine-protein kinase (KIN15/KIN16 subfamily) R09D1.14 R09D1.14 Protein with strong similarity to C. elegans R09D1.8 R09D1.2 R09D1.2 Member of the glycosyl hydrolase 18 family, has low similarity to chitinase 1 (chitotriosidase, human CHIT1), which catalyzes the hydrolysis of chitin and is associated with Gaucher disease and chitotriosidas chitinase R09D1.3 R09D1.3 Member of the glycosyl hydrolase 18 family, has low similarity to chitinase 3-like 1 (cartilage glycoprotein-39, human CHI3L1), which binds chitin but does not have chitinase activity and is expressed in rheumatoid arthritis cartilage and synovial cells chitinase R09D1.4 R09D1.4 Member of the glycosyl hydrolase 18 family, has a region of weak similarity to a region of chitinase 1 (human CHIT1), which catalyzes hydrolysis of chitin and is associated with Gaucher disease and chitotriosidase deficiency chitinase R09D1.5 R09D1.5 Member of the glycosyl hydrolase 18 family, has weak similarity to chitinase 3-like 3 (mouse Chi3l3), which is a lectin with chitinase activity that plays roles in chemotaxis and the response to infection with chitin-bearing microorganisms chitinase R09D1.6 R09D1.6 Member of the glycosyl hydrolase 18 family, has weak similarity to chitinase 3-like 1 (cartilage glycoprotein-39, human CHI3L1), which binds chitin but does not have chitinase activity and is expressed in rheumatoid arthritis cartilage and synovial cells chitinase R09D1.7 R09D1.7 Member of the glycosyl hydrolase 18 family, has low similarity to chitinase 3-like 1 (cartilage glycoprotein-39, human CHI3L1), which binds chitin but does not have chitinase activity and is expressed in rheumatoid arthritis cartilage and synovial cells chitinase R09D1.8 R09D1.8 Member of the glycosyl hydrolase 18 family, has weak similarity to chitinase 3-like 1 (cartilage glycoprotein-39, human CHI3L1), which binds chitin but does not have chitinase activity and is expressed in rheumatoid arthritis cartilage and synovial cells chitinase R09D1.9 R09D1.9 Member of the glycosyl hydrolase 18 family, has weak similarity to chitinase 3-like protein 1 (cartilage glycoprotein-39, human CHI3L1), which binds chitin and is expressed in rheumatoid arthritis cartilage and synovial cells chitinase R09E10.1 R09E10.1 Putative ortholog of C. elegans C17G10.3 gene product R09E10.2 R09E10.2 Member of the protein-tyrosine phosphatase family, which are involved in control of cell growth, proliferation, differentiation and transformation, has low similarity to a region of human PTPRJ, which is a receptor type protein tyrosine phosphatase R09E10.3 R09E10.3 Member of the AMP-binding enzyme family, has moderate similarity to acyl-CoA synthetase 5 (human FACL5), which catalyzes the synthesis of acyl-CoA from fatty acids, ATP, and CoA long-chain-fatty-acid-CoA ligase R09E10.4 R09E10.4 Member of the AMP-binding enzyme family, has moderate similarity to a region of acyl-CoA synthetase 5 (rat Acs5), which catalyzes the synthesis of acyl-CoA from fatty acids, ATP, and CoA with a substrate preference for C16-C18 unsaturated fatty acids long-chain-fatty-acid-CoA ligase R09E10.5 R09E10.5 Protein of unknown function, has high similarity to uncharacterized C. elegans F54D1.6 R09E10.6 R09E10.6 Protein of unknown function, has low similarity to uncharacterized C. elegans C15C6.2 R09E10.7 R09E10.7 Protein of unknown function The protein product of this gene is predicted to contain a glutamine/asparagine (Q/N)-rich ('prion') domain, by the algorithm of Michelitsch and Weissman (as of the WS77 release of WormBase, i.e., in wormpep77). R09E10.8 R09E10.8 Protein of unknown function, has weak similarity to C. elegans F30A10.2 R09E12.1 R09E12.1 Protein containing three DUF40 domains of unknown function, which contain four conserved cysteines, has low similarity to uncharacterized C. elegans C02A12.5 R09E12.2 R09E12.2 Protein containing a DUF40 domain of unknown function, which contain four conserved cysteines, has high similarity to uncharacterized C. elegans Y39G10AR.22 R09E12.3 R09E12.3 Protein containing six TPR (tetratrico peptide repeat) domains, which may mediate protein-protein interactions, has weak similarity to human TOMM34, which is a subunit of the mitochondrial translocase that is involved in mitochondrial protein import R09E12.4 R09E12.4 Member of the 7-transmembrane chemoreceptor family of G-protein coupled receptors (GPCR), has low similarity to C. elegans ODR-10, which is involved in odorant response 7TM chemoreceptor, str family R09E12.5 R09E12.5 Protein of unknown function, has very strong similarity to uncharacterized C. elegans K02E7.2 R09E12.6 R09E12.6 Protein of unknown function, has very strong similarity to uncharacterized C. elegans K02E7.3 R09F10.1 R09F10.1 Putative cathepsin (cysteine proteinase) peptidase R09F10.2 R09F10.2 Protein containing nine uncharacterized DUF139 cysteine repeat domains, has very strong similarity to uncharacterized C. elegans R09F10.7 abu-9 encodes a transmembrane protein (identical to that predicted for the pqn-57 gene) with a predicted signal sequence, a glutamine/asparagine-rich domain and multiple cysteine-rich repeats (DUF139); abu-9 expression is induced by blockage of the unfolded-protein response in the endoplasmic reticulum, and ABU-9 may help protect the organism from damage by improperly folded nascent protein. R09F10.3 R09F10.3 Protein of unknown function R09F10.4 opu-5;inx-5;R09F10.4 Member of the integral membrane innexin family, which are involved in the formation of gap junctions, has moderate similarity to C. elegans INX-3, which is an innexin that forms connexin-like intercellular channels unc-7-like protein; inx-5 encodes a predicted member of the innexin family; expressed in the embryonic hypodermis, developing vulva, seam cells, and spermatheca. R09F10.5 R09F10.5 Protein of unknown function, predicted to contain a glycosylphosphatidylinositol (GPI) lipid anchor R09F10.6 R09F10.6 Member of the 7-transmembrane chemoreceptor family of G-protein coupled receptors (GPCR), has low similarity to uncharacterized C. elegans C50B6.5 7TM chemoreceptor, srh family R09F10.7 R09F10.7 Protein containing nine uncharacterized DUF139 cysteine repeat domains, has very strong similarity to uncharacterized C. elegans R09F10.2 The protein product of this gene is predicted to contain a glutamine/asparagine (Q/N)-rich ('prion') domain, by the algorithm of Michelitsch and Weissman (as of the WS77 release of WormBase, i.e., in wormpep77). R09F10.8 R09F10.8 Member of an uncharacterized protein family; may be anchored to the membrane of a secretory vesicle or the Golgi apparatus R09F10.9 cip-1;R09F10.9 Protein of unknown function R09G11.1 sup-10;R09G11.1 Protein involved in coordination of muscle contraction R09G11.2 nhr-1;crf-1;R09G11.2 Putative nuclear hormone receptor; contains C4-type zinc finger domains; similar to human and D. melanogaster hepatocyte nuclear factors (HNF4) zinc finger protein; nhr-1 encodes a member of the nuclear receptor superfamily; phylogenetic analyses indicate that NHR-1 is a divergent nuclear receptor that likely arose from expansion and diversification of the HNF4 (NR2A) subgroup in C. elegans; nhr-1 reporter gene expression is detected in hypodermal cells from the 3-fold stage of embryogenesis until adulthood, but as loss of nhr-1 activity via mutation or large-scale RNAi screens does not result in any obvious abnormalities, the precise role of NHR-1 in C. elegans development and/or behavior is not yet known. R09H10.1 R09H10.1 Member of the domain of unknown function DUF13 family, has moderate similarity to uncharacterized C. elegans R09H10.2 R09H10.2 R09H10.2 Member of the domain of unknown function DUF13 family, has high similarity to uncharacterized C. elegans C17A2.7 R09H10.3 R09H10.3 Protein containing a transthyretin signature motif, has similarity to human transthyretin TTR transthyretin like; R09H10.3 is orthologous to the human gene TRANSTHYRETIN (PREALBUMIN, AMYLOIDOSIS TYPE I) (TTR; OMIM:176300), which when mutated leads to disease. R09H10.4 ptr-14;R09H10.4 Member of the Niemann-Pick(NPC)-like transmembrane protein family R09H10.5 R09H10.5 Protein with strong similarity to C. elegans C05D12.2 gene product EGF domains R09H3.1 R09H3.1 Protein of unknown function, has moderate similarity to uncharacterized C. elegans C38D9.3 R09H3.2 R09H3.2 Protein of unknown function R09H3.3 R09H3.3 Protein with moderate similarity to C. elegans C38D9.2 gene product R102.1 R102.1 Member of an uncharacterized protein family R102.2 R102.2 Member of an uncharacterized protein family R102.3 R102.3 Protein of unknown function, has weak similarity to C. elegans Y17G9B.A R102.4 R102.4 Putative threonine aldolase Yeast GLY1 like R102.5 R102.5 Protein of unknown function, contains a putative coiled-coil domain R102.6 R102.6 Protein of unknown function R102.7 R102.7 Protein of unknown function, has strong similarity in the C-terminal half to C. elegans BE10.1, has similarity to C. elegans R10E4.3 and T28C6.5 R102.8 R102.8 Protein of unknown function, putative paralog of C. elegans R102.4 R105.1 R105.1 Protein of unknown function, has moderate similarity to C. elegans T02H6.F R105.2 R105.2 Protein of unknown function R106.1 R106.1 Protein of unknown function R106.2 R106.2 Member of the rhodopsin family of G-protein coupled receptors (GPCR), has low similarity to somatostatin receptor 2 (human SSTR2), which inhibits adenylyl cyclase and mediates inhibition of cell proliferation and secretion of pituitary hormones G-protein coupled receptor R107.1 R107.1 Member of the Sodium:sulfate symporter family of membrane transporters, has low similarity to solute carrier family 13 (sodium-dependent dicarboxylate transporter member 3, rat Nadc3), which acts in di- and tri-carboxylic acid transport R107.2 R107.2 Member of the uncharacterized protein family UPF0031, has moderate similarity to uncharacterized S. pombe Spcc61.03p Uncharacterized protein family UPF0031 R107.4 R107.4 Protein with similarity over the N-terminus to serine/threonine protein kinases, putative paralog of C. elegans Y39G8B.F, expressed in the anal sphincter cell and intestinal muscle cells in L1 larvae tyrosine-protein kinase R107.5 R107.5 Protein of unknown function R107.6 R107.6 Protein of unknown function, has weak similarity to cytoplasmic linker protein associating protein 2 (human CLASP2), which is a microtubule-binding protein that may play a role in microtubule stabilization cls-2 encodes one of three predicted orthologs of mammalian CLASPs and of Drosophila ORBIT/MAST, microtubule-binding proteins required for fibroblast polarization and mitosis; cls-2 is required in mass RNAi assays for embryonic development and normal mitotic spindles; it has been claimed that, in an RNAi screen of potential microtubule tip-binding proteins, only cls-2(RNAi) yielded embryonic lethality and meiotic defects. R107.7 gst-1;R107.7 Protein containing glutathione S-transferase N-terminal and C-terminal domains, has moderate similarity to glutathione S-transferase pi 2 (mouse Gstp2), which conjugates glutathione to electrophilic compounds and may play a role in cancer susceptibility glutathione S-transferase; gst-1 encodes a putative glutathione S-transferase with highest similarity to the pi class. R107.8 lin-12;R107.8 Putative receptor involved in cell fate specification, has a well-characterized role in vulval development, member of the EGF-like repeat protein family and the Notch protein family LIN-12 protein; The lin-12 gene encodes a member of the Notch/LIN-12/glp-1 transmembrane receptor family that affects cell fate specification events during development, notably including the anchor cell, secondary vulval precursor cells, and the embryonic ABplp lineage; its expression is dynamic, including Z1. | The lin-12 gene encodes a member of the Notch/LIN-12/glp-1 transmembrane receptor family that affects cell fate specification events during development, notably including the anchor cell, secondary vulval precursor cells, and the embryonic ABplp lineage; its expression is dynamic, including Z1.ppp and Z4.aaa, ABplaa descendants, ABplpa descendants, and the intestinal primordium. R10A10.1 R10A10.1 Protein of unknown function R10A10.2 R10A10.2 Protein with high similarity to ring finger protein 7 (human RNF7), which acts as a cellular protective antioxidant against apoptosis induced by reactive oxygen species and metal ions zinc finger protein; The R10A10.2 gene encodes an ortholog of the mammalian zinc RING finger protein SAG, which protects cells from apoptosis induced by redox agents and is a component of ubiquitin-ligase (E3) complexes; mammalian SAG binds to the yeast Cul1 protein, complements the lethality of a mutation in yeast Sag, and (when bound to yeast Cul1) has ubiquitin ligase activity and promotes poly-ubiquitination of E2/Cdc34. R10D12.1 R10D12.1 Member of the sugar (and other) transporter family, has low similarity to brain-specific Na+-dependent inorganic phosphate cotransporter (rat Slc17a7), which is a vesicular glutamate transporter with a presynaptic role in glutamatergic neurotransmission sodium/phosphate transporter R10D12.10 R10D12.10 Protein containing a protein kinase domain, has weak similarity to S. cerevisiae Yck1p, which is a casein kinase I isoform serine/threonine kinase R10D12.11 R10D12.11 Member of the 7-transmembrane chemoreceptor family of G-protein coupled receptors (GPCR), has low similarity to uncharacterized C. elegans F26F12.6 R10D12.12 R10D12.12 Protein of unknown function, has moderate similarity to uncharacterized human MDS031 R10D12.13 R10D12.13 Protein of unknown function R10D12.14 R10D12.14 Protein containing a GYF (glycine, tyrosine, phenylalanine) domain, which are proline-binding domains R10D12.15 R10D12.15 Member of the plant chitinase class I family, which hydrolyze the beta-1,4-N-acetyl-D-glucosamine bonds in chitin polymers destroying cell walls of fungal and insect pathogens, has very strong similarity to uncharacterized C. elegans T26F2.1 chitinase R10D12.2 R10D12.2 Protein containing nuclear hormone receptor C4-type zinc finger and ligand-binding domains, has weak similarity to FTZ-F1 beta2 protein (rat Nr5a2), which is a transcriptional activator of the alpha-fetoprotein (Afp) gene Zinc finger, C4 type (two domains); dpr-1 encodes a putative nuclear hormone receptor that affects endoderm differentiation and may promote entry into the dauer state and maintenance of the dauer state; expressed in the endoderm lineage and localization appears dependent on growth conditions. R10D12.3 R10D12.3 Protein of unknown function, has high similarity to uncharacterized C. elegans F09F3.1 R10D12.4 R10D12.4 G protein-coupled receptor, member of an unnamed subfamily, no homolog in human or D. melanogaster 7TM receptor, srx family R10D12.5 R10D12.5 Putative ortholog of C. elegans ZC15.2 gene product G-protein coupled receptor R10D12.6 R10D12.6 Member of the uncharacterized protein family UPF0057, has high similarity to uncharacterized C. elegans R10D12.7 R10D12.7 R10D12.7 Member of the uncharacterized protein family UPF0057, has high similarity to uncharacterized C. elegans R10D12.6 R10D12.8 R10D12.8 Protein containing one BTB (BR-C, ttk and babor) or POZ (Pox virus and zinc finger) domain, which are found in some DNA and actin binding proteins and may mediate protein-protein interactions R10D12.9 R10D12.9 Member of the MtN3-saliva family, which contain a region of two transmembrane helices, has high similarity to uncharacterized C. elegans K11D12.5 R10E11.1 cbp-1;R10E11.1 Putative ortholog of human p300/CBP, histone acetyl transferase transcription coactivators and a member of the bromodomain protein family required for differentiation of non-neuronal cells bromodomain; cbp-1 encodes a homolog of the mammalian transcriptional cofactors CBP (OMIM:600140) and p300 (E1A-BINDING PROTEIN, 300-KD; OMIM:602700) that have been shown to possess histone acetyltransferase activity, and which, when mutated, lead to Rubinstein-Taybi syndrome (OMIM:180849) and colorectal cancer (OMIM:114500); at least one splicing form of CBP-1 exhibits histone acetyltransferase (HAT) activity in vitro and has a glutamine/asparagine-rich domain; CBP-1 is required during embryogenesis for differentiation of all non-neuronal somatic cell types; CBP-1 is expressed very early in embryogenesis, suggesting that it may interact with maternally provided transcription factors, such as SKN-1, to specific developmental fates. R10E11.2 vha-2;R10E11.2 Vacuolar-type H+ ATPase Vacuolar ATP synthase subunit; vha-2 encodes a 16-kDa proteolipid of the vacuolar-type H+-ATPase (V-ATPase) not required for embryonic viability; VHA-2 is 100% identical to VHA-3 with respect to amino acid sequence; vha-2 is located in a polycistronic region with vha-1 and it is expressed in the excretory cell, rectum, and a pair of cells posterior to the anus. R10E11.3 R10E11.3 Putative ortholog of H. sapiens USP12 (ubiquitin specific protease 12) Ubiquitin-specifc processing protease R10E11.4 sqv-3;R10E11.4 Galactosyl transferase I, involved in glycosaminoglycan biosynthesis; important for vulval invagination, has similarity to human XgalT-1 Galactosyltransferase; sqv-3 encodes a beta(1,4)-galactosyltransferase, biochemically active in vitro, that is required for cytokinesis of one-cell embryos, vulval morphogenesis, and chondroitin synthesis; SQV-3 is orthologous to human human galactosyltransferase I (B4GALT7; OMIM:604327, mutated in the progeroid form of Ehlers-Danlos syndrome); sqv-3 transgenically rescues hamster cells lacking galactosyl transferase I; the common requirement for SQV-3 in both cytokinesis and morphogenesis may be to promote filling an extracellular space with hygroscopic proteoglycans (either in the eggshell, or underneath the L4 cuticle), which in turn may cause the space to fill with fluid. R10E11.5 R10E11.5 Protein of unknown function R10E11.6 R10E11.6 Protein of unknown function, has a region of low similarity to a region of AP1 gamma subunit binding protein 1 (human AP1GBP1), which may be involved in intracellular protein trafficking R10E11.7 R10E11.7 Protein of unknown function, has low similarity to uncharacterized C. elegans Y44A6B.1 R10E11.8 vha-1;R10E11.8 Member of the V-ATPase proteolipid protein family ATP synthase subunit C (2 domains); vha-1 encodes a 16-kDa proteolipid of the vacuolar-type H+-ATPase (V-ATPase) and required for embryogenesis and for oocyte ovulation, based on RNAi analysis: expressed in the excretory cells and the rectum of adult animals as well as in a pair of cells posterior to the anus. | vha-1 encodes a 16-kDa proteolipid of the vacuolar-type H+-ATPase (V-ATPase) and is required for embryogenesis and for oocyte ovulation, based on RNAi analysis; expressed in the excretory cells and the rectum of adult animals as well as in a pair of cells posterior to the anus. R10E11.9 R10E11.9 Protein of unknown function, has weak similarity to C. elegans F42C5.6 R10E12.1 ynk1;R10E12.1 Protein containing two BRO1-like domains, which are found in some proteins involved in signal transduction, has low similarity to C. albicans Enx3p, which is involved in pH signaling R10E12.2 R10E12.2 Protein of unknown function, has moderate similarity to uncharacterized C. elegans C05B5.4 R10E4.1 R10E4.1 Protein containing one BTB (BR-C, ttk and babor) or POZ (Pox virus and zinc finger) domain, which are found in some DNA and actin binding proteins and may mediate protein-protein interactions R10E4.11 R10E4.11 Protein containing two C2H2 type zinc finger domains, which bind nucleic acids Zinc finger, C2H2 type R10E4.2 R10E4.2 Protein containing four RNA recognition motifs (RRM, RBD, or RNP), has low similarity to C. elegans RBP-1, which is a protein involved in oogenesis RNA recognition motif. (aka RRM, RBD, or RNP domain) (2 domains) R10E4.3 R10E4.3 Protein of unknown function, has strong similarity to C. elegans R102.7 R10E4.4 R10E4.4 Protein with high similarity to mini chromosome maintenance deficient 5 (human MCM5), which is a transcriptional coactivator that enhances IFNG -induced and STAT1 -dependent transactivation, member of the MCM family of DNA-dependent ATPases CDC46 R10E4.5 R10E4.5 Protein with similarity to E. coli endonuclease III endonuclease R10E4.6 R10E4.6 Protein of unknown function R10E4.7 R10E4.7 Protein of unknown function R10E4.8 R10E4.8 Member of the transposase family, which are required for excising and inserting mobile genetic elements, has very strong similarity to uncharacterized C. elegans C31A11.2 transposase R10E4.9 R10E4.9 Protein of unknown function R10E8.1 R10E8.1 Protein containing a DUF38 domain of unknown function R10E8.2 R10E8.2 Protein containing a DUF38 domain of unknown function R10E8.3 R10E8.3 Protein of unknown function, putative paralog of C. elegans R10E8.4 R10E8.4 R10E8.4 Protein of unknown function, has moderate similarity to uncharacterized C. elegans R10E8.3 R10E8.5 R10E8.5 Member of the 7-transmembrane chemoreceptor family of G-protein coupled receptors (GPCR), has low similarity to C. elegans ODR-10, which is involved in odorant response R10E8.6 R10E8.6 Protein containing six DUF38 domains of unknown function and an F-box domain, which serves as a link between a target protein and a ubiquitin-conjugating enzyme, has high similarity to uncharacterized C. elegans C01B9.1 This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins; this gene's encoded protein also contains an FTH/DUF38 motif, which may also mediate protein-protein interaction. R10E9.1 msi-1;R10E9.1 Has strong similarity to human MSI1, the musashi-like protein; putative RNA-binding protein contains two RNA recognition motifs RNA binding protein R10E9.2 R10E9.2 Protein of unknown function, has high similarity to uncharacterized C. elegans R07E5.15 R10E9.3 R10E9.3 Protein of unknown function R10F2.2 cdh-1;R10F2.1;R10F2.2 Protein containing fifteen cadherin domains, which are found in the extracellular domain of some receptors and cell adhesion proteins, has weak similarity to a region of cadherin related 23 (human CDH23), which is associated with Usher syndrome type 1D R10F2.4 R10F2.4 Protein of unknown function R10F2.5 R10F2.5 Protein of unknown function R10F2.6 R10F2.6 Member of the protein-tyrosine phosphatase family, which are involved in control of cell growth, proliferation, differentiation and transformation R10H1.1 R10H1.1 Protein containing two trypsin inhibitor-like cysteine rich domains trypsin inhibitor R10H1.2 R10H1.2 Member of the C. elegans Sre G protein-coupled chemoreceptor family, which are putative chemosensory receptors 7TM chemoreceptor, srab family R10H1.3 R10H1.3 Member of the Tc3 Transposase protein family transposase R10H10.1 R10H10.1 Protein containing a NifU-like domain, has high similarity to uncharacterized human HIRIP5 Yeast hypothetical protein YKE0 like; lpd-8 encodes a homolog of human and mouse HIRA-interacting protein-5; LPD-8 has C-terminal similarity to a domain of NifU observed in thioredoxin-like proteins and domains (COG0694), and is predicted to be mitochondrial on phylogenetic grounds. R10H10.2 spe-26;R10H10.2 Protein containing four Kelch motif domains, has weak similarity to gigaxonin (human GAN), which is a cytoskeletal protein that may be involved in neurofilament organization MIPP repeats; spe-26 encodes a Kelch motif-containing protein similar to the Drosophila proteins kelch and diablo and the Limulus (horseshoe crab) actin-bundling protein scruin; SPE-26 activity is required for several processes including embryogenesis, spermatogenesis, thermotolerance, and regulation of lifespan; SPE-26 mRNA is detected in spermatogonial cells and spermatocytes, but not in spermatids. R10H10.3 R10H10.3 Protein containing one CUB domain, which occurs extracellularly often in developmentally regulated proteins CUB domain, von Willebrand factor type A domain R10H10.4 R10H10.4 Protein of unknown function, has high similarity to uncharacterized C. elegans T01C8.2 R10H10.5 gpa-7;R10H10.5 Member of the G protein alpha subunit family guanine nucleotide-binding protein; gpa-7 encodes a member of the G protein alpha subunit family of heterotrimeric GTPases that affects egg laying and response to water- soluble odorants; it is expressed in excitable cells. R10H10.6 R10H10.6 Member of the riboflavin kinase or FAD synthetase family, has low similarity to a region of riboflavin kinase (S. cerevisiae Fmn1p), which is involved in vitamin B2 biosynthesis Yeast protein YD8419.03c like R10H10.7 R10H10.7 Protein containing a Src homology 2 (SH2) domain, which are regulatory modules of intracellular signaling tyrosine-protein kinase like R11.1 R11.1 Protein with high similarity to solute carrier family 25 member 21 (human SLC25A21), which is a mitochondrial oxodicarboxylate carrier associated with 2-oxoadipate acidemia, member of the mitochondrial carrier protein family of membrane transporters mitochondrial transporter protein R11.2 R11.2 Protein of unknown function R11.3 R11.3 Protein of unknown function R11.4 R11.4 Protein of unknown function, predicted to contain a glycosylphosphatidylinositol (GPI) lipid anchor R119.1 R119.1 Protein of unknown function R119.2 R119.2 Protein with similarity to aminopeptidase peptidase R119.3 R119.3 Member of the short-chain dehydrogenase-reductase family, which are NAD- or NADP-dependent oxidoreductases, has low similarity to mouse H2-Ke6, which is a 17-beta dehydroxysteroid dehydrogenase that is involved in androgen and estrogen metabolism dehydrogenase; This gene encodes a protein predicted by Eisenberg and coworkers, with 68% accuracy, to be mitochondrial. R119.4 prp-1;R119.4 Putative RNA-binding protein The protein product of this gene is predicted to contain a glutamine/asparagine (Q/N)-rich ('prion') domain, by the algorithm of Michelitsch and Weissman (as of the WS77 release of WormBase, i.e., in wormpep77). R119.5 R119.5 Protein of unknown function R119.6 taf-5;R119.6 Putative component of RNA polymerase II pre-initiation complex, required for embryonic transcription taf-4 encodes a TAFII (TBP(TATA-binding protein)-associated factor) that is orthologous to human TAF4 (hTAFII130); TAF-4 is predicted to be a component of the TFIID mRNA transcription complex and is generally required for early embryonic mRNA transcription; consistent with this observation, taf-4(RNAi) results in embryonic lethality at the ~100-cell stage with little cell differentiation, similar to the loss of AMA-1/RNA polymerase II activity; TAF-4 is detected in nuclei in the adult germline, oocytes, and embryo, from the 2-cell stage through early morphogenesis. R119.7 R119.7 Protein containing an RNA recognition motif (RRM, RBD, or RNP) R11A5.1 R11A5.1 Protein containing two clathrin-associated adaptin N-terminal domains, has moderate similarity to adaptor-related protein complex 3 beta 1 subunit (mouse Ap3b1), which is a subunit of the AP-3 adaptor complex involved in protein sorting to lysosomes Human beta-nap protein like; apt-6 encodes an adaptin, orthologous to the beta3 subunit of adaptor protein complex 3 (AP-3); based on structural similarity, APT-6 may be involved in the formation of intracellular transport vesicles. R11A5.2 R11A5.2 Protein of unknown function R11A5.3 R11A5.3 Protein of unknown function R11A5.4 R11A5.4 Protein with high similarity to phosphoenolpyruvate carboxykinase 2 (human PCK2), which catalyzes the formation of phosphoenolpyruvate by decarboxylation of oxaloacetate, member of the phosphoenolpyruvate carboxykinase (GTP) family phosphoenolpyruvate carboxykinase R11A5.5 R11A5.5 Protein containing three GLTT repeat region domains R11A5.6 R11A5.6 Protein of unknown function R11A5.7 R11A5.7 Putative carboxypeptidase, has strong similarity to human carboxypeptidases zinc carboxypeptidase R11A8.1 R11A8.1 Protein with weak similarity to S. cerevisiae USO1 (Coiled-coil protein with similarity to mammalian integrin, required for protein transport from ER to Golgi) R11A8.2 R11A8.2 Protein of unknown function, has low similarity to uncharacterized human T54 R11A8.3 R11A8.3 Member of the UDP-glucuronosyltransferase protein family UDP-glucuronosyltransferase R11A8.4 sir-2.1;R11A8.4 Member of the Sir2 family of putative NAD-dependent histone deacetylases, functions in extended life span and dauer formation, has similarity to S. cerevisiae Sir2p Yeast regulatory protein SIR2 like; sir-2.1 encodes a homolog of the S. cerevisiae gene SIR2. R11A8.5 R11A8.5 Protein with similarity to D. melanogaster SU(P), suppressor of ref(2)P sterility, related to glutathione S-transferases glutathione S-transferase R11A8.6 R11A8.6 Protein with high similarity to isoleucine-tRNA synthetase (human IARS), which aminoacylates isoleucyl-tRNA with isoleucine for protein biosynthesis, member of the class I isoleucyl, leucyl, valyl, and methionyl (I, L, M, and V) tRNA synthetase family isoleucyl-tRNA synthetase R11A8.7 R11A8.7 Protein containing two KH domains and multiple ankyrin (Ank) repeats, has a region of low similarity to a region of C. elegans UNC-44, which is involved in axonogenesis and axon guidance ankyrin repeats; The protein product of this gene is predicted to contain a glutamine/asparagine (Q/N)-rich ('prion') domain, by the algorithm of Michelitsch and Weissman (as of the WS77 release of WormBase, i.e., in wormpep77). R11B5.1 R11B5.1 Protein with a predicted TBC domain, has strong similarity to human KIAA0608 protein (Hs.45054, isolated from a brain cDNA library) R11D1.1 R11D1.1 Protein containing four WD domains (WD-40 repeat), which may mediate protein-protein interactions WD domain, G-beta repeat R11D1.10 R11D1.10 Protein with weak similarity to S. cerevisiae NSR1 (Nucleolar protein involved in processing 20S to 18S rRNA) R11D1.11 R11D1.11 Member of the short-chain dehydrogenase-reductase family, which are NAD- or NADP-dependent oxidoreductases, has low similarity to 1,3,6,8-tetrahydroxynaphthalene reductase (A. fumigatus Arp2), which is involved in conidial pigment biosynthesis Mouse adipocyte P27 protein like; dhs-21 encodes a member of the short-chain dehydrogenases/reductases family (SDR) expressed in the intestine, hypodermis, uterus, and spermatheca. R11D1.2 R11D1.2 Protein of unknown function, has weak similarity to C. elegans K08C9.5 R11D1.3 R11D1.3 Protein of unknown function, has moderate similarity to uncharacterized C. elegans R11D1.4 R11D1.4 R11D1.4 Protein of unknown function, has moderate similarity to uncharacterized C. elegans R11D1.3 R11D1.5 R11D1.5 Member of the 7-transmembrane chemoreceptor family of G-protein coupled receptors (GPCR), has high similarity to uncharacterized C. elegans R11D1.6 7TM receptor R11D1.6 R11D1.6 Member of the 7-transmembrane chemoreceptor family of G-protein coupled receptors (GPCR), has low similarity to C. elegans ODR-10, which is involved in odorant response 7TM receptor R11D1.7 R11D1.7 Protein of unknown function R11D1.8 R11D1.8 Member of the ribosomal L28e family, which are part of the large ribosomal subunit ribsomal protein L28 like; rpl-28 encodes a large ribosomal subunit L28 protein. R11D1.9 R11D1.9 possible mitochondrial large ribosomal subunit protein Human NOF1 protein like R11E3.1 R11E3.1 Protein containing a protein kinase domain, has low similarity to Fer (fps/fes related) tyrosine kinase (mouse Fert2), which may mediate cell-cell signaling and play a role in cell size-dependent cytoskeletal reorganization and cell cycle control protein kinase R11E3.2 R11E3.2 Member of the nucleobase transporter protein family permease R11E3.3 R11E3.3 Member of the apurinic or apyrimidinic (AP) endonuclease family 1, which cleave DNA, member of the reverse transcriptase family, which are RNA-dependent DNA polymerases, has weak similarity to a region of LINE retrotransposable element 1 (human LRE1) reverse transcriptase R11E3.4 R11E3.4 Protein containing a SET domain, which are involved in protein-protein interactions, has low similarity to uncharacterized C. elegans C49F5.2 R11E3.5 R11E3.5 Protein containing a nuclear hormone receptor C4-type zinc finger domain, which bind DNA and may regulate transcription, and a nuclear hormone receptor ligand-binding domain, has weak similarity to hepatocyte nuclear factor 4 gamma (mouse Hnf4g) nuclear hormone receptor R11E3.6 R11E3.6 Protein containing nine C2H2 type zinc finger domains and a BTB or POZ (Pox virus and zinc finger) domain, has a region of low similarity to a region of zinc finger protein 85 (human ZNF85), which functions as a transcriptional co-repressor zinc-finger protein; eor-1 encodes an ortholog of the human BTB/zinc-finger transcription factor PLZF (OMIM:176797), which is is found as a retinoic acid receptor alpha (RARA) fusion in acute promyelocytic leukemia (APL); EOR-1 positively regulates RAS/RAF-mediated signalling during excretory system development, as well as RAS/RAF- and WNT-mediated signalling during P12 fate specification; EOR-1 may function with EOR-2 and Hox genes to control the expression of Ras- and Wnt-responsive genes. R11E3.7 R11E3.7 Protein of unknown function, has weak similarity to uncharacterized C. elegans R11E3.8 R11E3.8 R11E3.8 Protein with moderate similarity to N-acylaminoacyl-peptide hydrolase (rat Apeh), which catalyzes the hydrolysis of an amino-terminally acetylated peptide to release an N-acetylamino acid This gene encodes a protein predicted by Eisenberg and coworkers, with 52% accuracy, to be mitochondrial. R11F4.1 R11F4.1 Protein with high similarity to glycerol kinase (human GK), which catalyzes the phosphorylation of glycerol to glycerol 3-phosphate, contains FGGY family of carbohydrate kinases N-terminal and C-terminal domains Glycerol kinase; The R11F4.1 gene encodes a homolog of human glycerol kinase (GK), which when mutated leads to hyperglycerolemia (glycerol kinase deficiency; OMIM:307030). R11F4.2 R11F4.2 Protein of unknown function, has low similarity to uncharacterized C. elegans F32D8.10 R11F4.3 R11F4.3 Protein of unknown function, predicted to contain a glycosylphosphatidylinositol (GPI) lipid anchor R11G1.1 R11G1.1 Protein containing two low-density lipoprotein (LDL) receptor class A domains, has a region of low similarity to a region of mucin 2 (human MUC2), which is an secreted glycoprotein associated with neoplastic cells and mucus obstruction in cystic fibrosis LDL receptor related protein R11G1.2 R11G1.2 Protein of unknown function, has weak similarity to C. elegans C17F4.2 R11G1.3 R11G1.3 Protein containing glutathione S-transferase N- and C-terminal domains, has moderate similarity to prostaglandin D2 synthase (human PGDS), which is a prostaglandin D synthase and glutathione S-transferase that regulates non-rapid eye movement sleep glutathione S-transferase R11G1.4 sax-1;R11G1.4 Serine/threonine protein kinase with strong similarity to H. sapiens and D. melanogaster nuclear protein kinase NDR, has similarity to S. cerevisiae nuclear protein kinases Dbf2p and Dbf20p protein kinase; The sax-1 gene encodes a homolog of Ndr kinase that regulates neuronal cell shape and neurite initiation. R11G1.5 R11G1.5 Protein of unknown function R11G1.6 R11G1.6 Protein of unknown function R11G10.1 avr-15;T10G3.7;R11G10.1;GluClalpha2 Subunits of a glutamate-gated chloride channel, GluClalpha2A and GluClalpha2B glutamate-gated chloride channel; avr-15 encodes, via alternative splicing, two glutamate-gated chloride channel subunit homologs; these proteins mediate fast inhibitory glutamatergic neuromuscular transmission, as well as ivermectin sensitivity, and are required for normal pharyngeal function. R11G10.2 R11G10.2 Protein of unknown function, has moderate similarity to uncharacterized C. elegans Y37A1B.5 selenium-binding protein like R11G11.1 R11G11.1 Protein with high similarity to C. elegans NHR-58, contains two nuclear hormone receptor C4-type zinc finger domains and a nuclear hormone receptor ligand-binding domain zinc finger protein R11G11.10 R11G11.10 Protein of unknown function, has high similarity to uncharacterized C. elegans R11G11.13 R11G11.11 R11G11.11 Protein of unknown function, has strong similarity to C. elegans R11G11.10 R11G11.12 R11G11.12 Protein containing a nuclear hormone receptor C4-type zinc finger domain, which bind DNA and may be involved in regulation of transcription, has moderate similarity to C. elegans NHR-58, which is involved in embryogenesis and morphogenesis zinc finger protein R11G11.13 R11G11.13 Protein of unknown function, has high similarity to uncharacterized C. elegans ZK488.9 7TM chemoreceptor, srw family R11G11.14 R11G11.14 Protein with moderate similarity to gastric lipase (human LIPF), which is a serine esterase lipase expressed in the stomach that catalyzes the hydrolysis of dietary triacylglycerol substrates and plays a role in neutral lipid metabolism lipase R11G11.2 nhr-58;R11G11.2 Member of the nuclear hormone receptor/Zinc finger protein family zinc finger protein R11G11.3 R11G11.3 Predicted member of the serpin superfamily according to sequence similarity R11G11.5 R11G11.5 Protein with strong similarity to C. elegans ZK697.5 gene product 7TM chemoreceptor, srw family R11G11.6 R11G11.6 Protein containing a DUF148 domain of unknown function, has high similarity to uncharacterized C. elegans ZK488.10 R11G11.7 R11G11.7 Protein containing a DUF148 domain of unknown function, has high similarity to uncharacterized C. elegans ZK488.10 The protein product of this gene is predicted to contain a glutamine/asparagine (Q/N)-rich ('prion') domain, by the algorithm of Michelitsch and Weissman (as of the WS77 release of WormBase, i.e., in wormpep77). R11G11.8 R11G11.8 Protein of unknown function, has high similarity to uncharacterized C. elegans ZK488.8 R11G11.9 srh-37;R11G11.9 Protein of unknown function, has strong similarity to uncharacterized C. elegans C31B8.11 7TM chemoreceptor, srh family R11H6.1 R11H6.1 Putative ortholog of S. cerevisiae Yfr044p, a protein of unknown function Yeast hypothetical 52.9 KD protein like; pes-9 encodes a zinc metallopeptidase; pes-9 was originally identified in a promoter trap screen for sequences that direct reporter gene expression in specific cell types during C. elegans development; pes-9 sequences direct expression in a limited number of cells in the early embryo and in putative head and tail hypodermal cells in adults; after some confusion, the pes-9 reporter gene fusion was mapped to R11H6.1. R11H6.2 R11H6.2 Protein of unknown function, has moderate similarity to uncharacterized human KIAA1253 Human placenta (DIFF33) protein like R11H6.3 R11H6.3 Protein of unknown function, has weak similarity to uncharacterized C. elegans F46C8.7 R11H6.4 R11H6.4 Protein of unknown function R11H6.5 R11H6.5 Protein with moderate similarity to nuclear factor 45 (human ILF2), which is a component of the nuclear factor of activated T cells (NFAT) and a transcription factor that is required for T-cell expression of interleukin 2 (IL2) Human NF45 protein like R12A1.2 R12A1.2 Protein containing two C2 domains, which may be involved in calcium-dependent phospholipid binding, has low similarity to synaptotagmin 7 (rat Syt7), which regulates exocytosis and may facilitate entry of Trypanosoma cruzi into cells via lysosomes R12A1.3 R12A1.3 Protein containing a WAP-type (Whey Acidic Protein) four-disulfide core domain and a kunitz or bovine pancreatic trypsin inhibitor domain protease inhibitor R12A1.4 ges-1;ges1;R12A1.4 Carboxylesterase expressed in gut cells carboxylesterase; ges-1 encodes a gut-specific type B carboxylesterase; by homology, GES-1 hydrolyzes carboxylic ester substrates to yield an alcohol and a carboxylic anion, however, loss of GES-1 activity via mutation or RNAi does not result in any obvious abnormalities; GES-1 is expressed solely in the intestinal, or E, lineage from the 4 E-cell stage of gut development through adulthood; GES-1 contains a C-terminal endoplasmic reticulum (ER) retention sequence, KDEL, which suggests that it localizes to the ER lumen; GES-1 expression in the gut appears to be positively regulated by ELT-2, a gut-specific GATA-type transcription factor expressed throughout the C. elegans life cycle and essential for normal gut development. R12B2.1 sma-4;cem-3;R12B2.1 Smad protein similar to vertebrate DPC4 that may act as a general cofactor for pathway-specific Smads SMA-2 and SMA-3 The sma-4 gene encodes a homolog of human DPC4, which when mutated leads to pancreatic carcinoma (OMIM:260350). R12B2.2 R12B2.2 Protein of unknown function, has similarity over the N-terminal two-thirds to human basic-leucine zipper nuclear factor JEM1 R12B2.3 R12B2.3 Protein of unknown function R12B2.4 him-10;NUF2;R12B2.4 Coiled coil protein structurally related to H. sapiens Nuf2 and S. pombe Nuf2, component of the kinetochore R12B2.5 R12B2.5 Protein of unknown function R12B2.6 R12B2.6 Protein with weak similarity to C. elegans F01F1.7 (Putative U5 snRNP-associated splicing factor, putative ortholog of human U5-100K protein and yeast Prp28p, member of the RNA helicase protein family) R12C12.1 R12C12.1 Protein with high similarity to glycine dehydrogenase (P-protein) (human GLDC), which catalyzes the decarboxylation of glycine and is associated with nonketotic hyperglycinemia, member of the glycine cleavage P-protein family Glycine dehydrogenase; R12C12.1 is orthologous to human GLYCINE DECARBOXYLASE (GLDC; OMIM:238300), which when mutated leads to glycine encephalopathy. R12C12.2 R12C12.2 Protein containing a RanBP1 domain, which mediate protein-protein interactions, has low similarity to a region of ran binding protein 3 (human RANBP3), which binds the Ran GTPase (human RAN) and is a nuclear effecter of the Ran pathway ran-5 encodes a protein containing a RanBP1 domain, domains which are predicted to interact with Ran proteins to inhibit dissociation of GTP and to stimulate GAP-mediated GTP hydrolysis by Ran, that affects body morphology, locomotion, and embryonic viability. R12C12.3 R12C12.3 Member of the rhodopsin family of G-protein coupled receptors (GPCR), has weak similarity to galanin receptor 2 (rat Galr2), which modulates adenylyl cyclase, phospholipase C and intracellular calcium and regulates jejunal contraction and pain perception thyrotropin-releasing hormone receptor R12C12.4 R12C12.4 Protein of unknown function R12C12.5 R12C12.5 Protein of unknown function, has moderate similarity to uncharacterized C. elegans C56C10.3 R12C12.6 R12C12.6 Protein of unknown function, has low similarity to uncharacterized human C11orf15 R12C12.7 R12C12.7 Protein with strong similarity to C. elegans K02B7.1 gene product R12C12.8 R12C12.8 Putative ortholog of C. elegans C25H3.8 gene product R12C12.9 R12C12.9 Protein of unknown function R12E2.1 R12E2.1 Protein containing five Kelch motif domains and a BTB or POZ domain, has moderate similarity to kelch-like 2 (Mayven) (human KLHL2), which is a protein-binding protein and putative transporter that may be involved in intracellular protein traffic R12E2.10 R12E2.10 Protein with very strong similarity to C. elegans T21E3.1, which is involved in eggshell formation, member of the protein-tyrosine phosphatase family, which are involved in control of cell growth, proliferation, differentiation and transformation protein-tyrosine phosphatase R12E2.11 R12E2.11 Protein containing a phosphoribosyl transferase domain, has low similarity to orotate phosphoribosyltransferase 1 (S. cerevisiae Ura5p), which catalyzes the fifth step in the pyrimidine biosynthesis pathway purine/pyrimidine phosphoribosyl transferase R12E2.12 R12E2.12 Possible mitochondrial small ribosomal subunit protein R12E2.13 R12E2.13 Protein containing three MIR (protein mannosyltransferase, IP3R and RyR) domains, has low similarity to a region of mannosyltransferase (dolichyl phosphate-D-mannose:protein O-D-mannosyltransferase, S. cerevisiae Pmt2p), which initiates O-glycosylation R12E2.14 R12E2.14 Protein of unknown function R12E2.15 R12E2.15 Protein of unknown function R12E2.2 R12E2.2 Protein of unknown function R12E2.3 rpn-8;R12E2.3 Putative subunit (non-ATPase) of the 19S particle of the 26S proteasome complex R12E2.4 R12E2.4;1E733 Member of the integral membrane innexin family, which are involved in the formation of gap junctions, has low similarity to C. elegans UNC-9, which is required for normal locomotion R12E2.5 R12E2.5 Member of the integral membrane innexin family, which are involved in the formation of gap junctions, has moderate similarity to C. elegans INX-3, which is an innexin that forms connexin-like intercellular channels inx-16 encodes an innexin, an integral transmembrane channel protein that is a structural component of invertebrate gap junctions; as loss of INX-16 activity via RNA-mediated interference (RNAi) does not result in any abnormalities, the precise role of INX-16 in C. elegans development and/or behavior is not yet known; the INX-16 expression pattern has not been determined. R12E2.6 R12E2.6 Protein of unknown function R12E2.7 R12E2.7 Protein of unknown function R12E2.8 R12E2.8 Protein of unknown function R12E2.9 R12E2.9 Member of the integral membrane innexin family, which are involved in the formation of gap junctions, has low similarity to C. elegans UNC-9, which is required for normal locomotion R12G8.1 R12G8.1 Putative protein kinase C isoform, has strong similarity to human, D. melanogaster, and S. cerevisiae protein kinase C isoforms Phorbol esters / diacylglycerol binding domain (2 domains) R12G8.2 R12G8.2 Member of the potassium channel TWK-13 protein family R12H7.1 unc-9;R12H7.1 Member of the OPUS/innexin protein family required for normal locomotion UNC-7-like protein; unc-9 encodes an innexin, an integral transmembrane channel protein that is a structural component of invertebrate gap junctions; UNC-9 is required for normal forward locomotion and egg-laying and also plays a role in the response to antihelminthics and volatile anesthetics; UNC-9 may form a functional pair with UNC-7, another C. elegans innexin, as mutations in unc-7 result in defects nearly identical to those in unc-9 mutant animals. R12H7.2 asp-4;R12H7.2 Probable aspartyl protease and ortholog of human cathepsin D aspartyl protease; asp-4 encodes an aspartyl protease homolog that is required, in parallel with ASP-3 but downstream of CLP-1 and TRA-3, for degenerative (necrotic-like) cell death in neurons induced by mutations such as mec-4(d), deg-3(d), or gsa-1(gf). R12H7.3 skr-19;R12H7.3 Member of the Skp1 family, which are required for targeted protein degradation during the cell cycle, has moderate similarity to uncharacterized C. elegans SKR-1 RNA polymerase II elongation factor like; The skr-19 gene encodes a homolog of Skp1 in S. cerevisiae that has no known function in vivo, since skr-19(RNAi) animals are at least superficially normal. R12H7.4 R12H7.4 Putative aspartic protease R12H7.5 skr-20;R12H7.5 Member of the Skp1 family, which are required for targeted protein degradation during the cell cycle, has low similarity to a region of S. cerevisiae Skp1p, which is a component of the Cbf3 kinetochore and SCF (Skp1p-cullin-F-box) complexes RNA polymerase II elongation factor like; The skr-20 gene encodes a homolog of Skp1 in S. cerevisiae that has no known function in vivo, since skr-20(RNAi) animals are at least superficially normal. R13.1 R13.1 Protein containing a MIZ zinc finger domain R13.2 R13.2 One member of a four protein Pax-like gene family, the Npax family, in C. elegans; the protein contains only the N-terminal PAI subdomain of the Paired domain paired box protein like R13.3 R13.3 Member of the C. elegans putative membrane protein family 8, has moderate similarity to uncharacterized C. elegans ZK688.2 Putative membrane protein R13.4 R13.4 Protein of unknown function R134.1 gcy-3;R134.1 Putative guanylyl cyclase guanylate cyclase; gcy-3 is predicted to encode a guanylate cyclase. R134.2 gcy-2;R134.2 Putative guanylyl cyclase guanylate cyclase; gcy-2 encodes a predicted transmembrane guanylyl cyclase; as loss of gcy-2 activity via RNA-mediated interference does not result in any abnormalities, the precise role of GCY-2 in C. elegans development and/or behavior is not yet known; by sequence similarity, however, GCY-2 can be predicted to function in chemosensory signal transduction. R13A1.1 R13A1.1 Protein of unknown function R13A1.2 R13A1.2 Protein with moderate similarity to solute carrier family 12 member 4 (human SLC12A4), which is a potassium-chloride cotransporter that mediates chloride dependent cell-swelling activated potassium effux and is involved in cell volume regulation This gene encodes a protein predicted by Eisenberg and coworkers, with 52% accuracy, to be mitochondrial. R13A1.3 R13A1.3 Protein containing one BTB (BR-C, ttk and babor) or POZ (Pox virus and zinc finger) domain, which are found in some DNA and actin binding proteins and may mediate protein-protein interactions, has high similarity to uncharacterized C. elegans B0496.2 degenerin R13A1.4 unc-8;R13A1.4 Member of the amiloride-sensitive sodium channel family, degenerin family and DEG/ENaC superfamily of proteins degenerin; unc-8 encodes an amiloride-sensitive DEG/ENaC cation-selective channel subunit orthologous to human ENaCB (OMIM:600760, associated with Liddle syndrome, an autosomal dominant form of hypertension); UNC-8 is predicted to function as part of a mechanically gated channel that responds to stretch, and is required for modulating the sinusoidal body wave that is characteristic of C. elegans locomotion; unc-8 interacts genetically with unc-1 and unc-24, which encode stomatin-like proteins, and with mec-6, which encodes a paraoxonase; UNC-8 is expressed in motor neurons, sensory neurons, and interneurons in the nerve ring; UNC-8 may form a channel with the degenerin DEL-1, with which it is coexpressed in ventral cord motor neurons. R13A1.5 R13A1.5 Protein of unknown function R13A1.7 R13A1.7 Protein of unknown function Na-K-Cl cotransporter R13A1.8 R13A1.8 Member of the globin family of oxygen transporters R13A5.1 cup-5;R13A5.1 Putative ortholog of human mucolipin-1; functions in endocytosis The cup-5 gene encodes an ortholog of the human mucolipin-1 gene, and is required for the normal, negative regulation of endocytotic uptake of markers from pseudocoelomic fluid. R13A5.10 R13A5.10 Protein containing a cytidine deaminase zinc-binding domain, has high similarity to uncharacterized C. elegans Y48A6B.7 R13A5.11 R13A5.11 Serine/threonine protein phosphatase Protein phosphatase R13A5.12 R13A5.12 Member of the Ygr103p-like protein family R13A5.3 R13A5.3 Member of the transthyretin-like family, has high similarity to uncharacterized C. elegans R13A5.6 R13A5.4 R13A5.4 Protein containing two neurotransmitter-gated ion-channel ligand binding domains, has weak similarity to C. elegans UNC-29, which is a subunit of the acetylcholine receptor family ACHR R13A5.5 ceh-13;R13A5.5 Homeodomain transcription factor with role in embryonic development, has similarity over 191 amino acids to human HOX A1, which is thought to act in early development a homolog of Hox genes of labial/Hox1 type; affects viability, body shape and anterior patterning during embryogenesis, interacts genetically with hox genes; and is expressed in A, D, E and MS lineages in the early embryo, and in the anterior dorsal hypodermal cells, anterior body wall muscle cells, and in the cells of the prospective ventral nerve cord at the comma stage; and in the ventral nerve cord and and ventral and dorsal hypodermal cells in L1 larvae. R13A5.6 R13A5.6 Member of the transthyretin-like family, has high similarity to uncharacterized C. elegans C40H1.5 R13A5.7 R13A5.7 Protein of unknown function R13A5.8 R13A5.8 Member of the ribosomal protein L9 protein family Ribosomal protein L9; rpl-9 encodes a large ribosomal subunit L9 protein that affects fertility and embryonic viability. R13A5.9 R13A5.9 Protein of unknown function R13D11.1 R13D11.1 Protein of unknown function, has high similarity to uncharacterized C. elegans F41H8.2, which is predicted to be a G protein-coupled receptor R13D11.10 R13D11.10 Protein of unknown function R13D11.3 R13D11.3 G protein-coupled receptor, member of an unnamed subfamily, no homolog found in human or D. melanogaster R13D11.4 R13D11.4 Putative ortholog of C. elegans F17A9.5 gene product R13D11.5 R13D11.5 G protein-coupled receptor, member of a subfamily with SRB proteins which are expressed in chemosensory neurons, no homolog found in human or D. melanogaster R13D11.6 R13D11.6 G protein-coupled receptor, member of a subfamily with SRB proteins which are expressed in chemosensory neurons, no homolog found in human or D. melanogaster 7TM chemoreceptor, srab family R13D11.7 R13D11.7 Protein of unknown function, has weak similarity to uncharacterized C. elegans K06C4.15 R13D11.8 R13D11.8 Protein containing nuclear hormone receptor C4-type zinc finger and ligand-binding domains, has a region of low similarity to a region of hepatocyte nuclear factor 4 alpha (human HNF4A), which is a transcription factor regulating liver gene expression R13D11.9 R13D11.9 Putative G protein-coupled receptor, has weak similarity to human G protein-coupled receptor 50 7TM chemoreceptor, srx family R13D7.1 R13D7.1 Member of the 7-transmembrane chemoreceptor family of G-protein coupled receptors (GPCR), has low similarity to C. elegans ODR-10, which is involved in odorant response 7TM chemoreceptor, str family R13D7.10 R13D7.10 Protein containing a DUF32 domain of unknown function, has high similarity to uncharacterized C. elegans C50H11.4 7TM chemoreceptor, srt family R13D7.2 R13D7.2 Protein of unknown function, has moderate similarity to uncharacterized C. elegans C12D5.9 R13D7.3 R13D7.3 Member of the 7-transmembrane chemoreceptor family of G-protein coupled receptors (GPCR), has low similarity to C. elegans ODR-10, which is involved in odorant response 7TM chemoreceptor, srj family R13D7.4 R13D7.4 Member of the 7TM receptor protein family 7TM chemoreceptor, srx family R13D7.6 R13D7.6 Protein of unknown function, has high similarity to uncharacterized C. elegans Y49C4A.4 7TM chemoreceptor, srx family R13D7.7 R13D7.7 Protein containing glutathione S-transferase N-terminal and C-terminal domains, has moderate similarity to glutathione S-transferase p1 (human GSTP1), which is involved in carcinogen detoxification and protection against reactive oxygen species glutathione S-transferase R13F6.1 R13F6.1 Protein of unknown function R13F6.10 R13F6.10 Protein of unknown function R13F6.2 R13F6.2 Protein of unknown function, has strong similarity to uncharacterized C. elegans R13F6.8 R13F6.3 srg-12;R13F6.3 G protein-coupled receptor, probably involved in chemosensation by sensory amphid neurons, no homolog found in human or D. melanogaster 7TM chemoreceptor, srv family R13F6.4 R13F6.4 Protein containing four epidermal growth factor (EGF)-like domains and two NHL repeats, has low similarity to neuregulin 1 (mouse Nrg1), which activates mouse Erbb2 and other members of the EGF receptor family of tyrosine kinase-linked receptors R13F6.5 R13F6.5 Protein containing a DHHC-type zinc finger (NEW1) domain, has low similarity to uncharacterized human FLJ14524 R13F6.6 R13F6.6 Protein containing a protein kinase domain, has a region of low similarity to a region of human ZAK, which is a mixed lineage kinase protein that stimulates the JNK/SAPK pathway and activates NF-kappaB R13F6.8 R13F6.8 Member of the C-type lectin family R13F6.9 sma-3;cem-2;R13F6.9 R-Smad (receptor-regulated Smad) is a component of the TGF-beta signaling pathway affecting postembryonic growth and male tail development R13G10.1 dpy-27;R13G10.1 Member of the highly conserved SMC family of proteins; specifically required for proper dosage compensation chromosome segregation protein (SMC-1); The dpy-27 gene encodes a homolog of the SMC4 subunit of mitotic condensin; DPY-27, in combination with other proteins including MIX-1, act as a unit to repress X-linked genes during dosage compensation. R13G10.2 R13G10.2 Member of the flavin containing amine oxidase family, has a region of weak similarity to monoamine oxidase B (human MAOB), which is involved in the metabolism of various biologically important amines such as dopamine monoamine oxidase R13G10.4 R13G10.4 Protein containing two CBS (cystathionine-beta-synthase) domains and a DUF21 domain of unknown function, has a region of weak similarity to a region of S. cerevisiae Ami3p, which is required for normal mitochondrial structure R13G10.4 encodes a homolog of human ACDP1-ACDP4 and a paralog of C01H6.6, C33D12.2, C52D10.12, M02F4.3, and R04E5.2; both R13G10.4 and ACDP1-ACDP4 belong to a family of proteins (defined by NCBI as KOG2118) that are predicted to be membrane-spanning and that share a motif (the 'ACD domain') with proteins from bacteria, yeast, plants, and metazoa; murine Acdp1 is a plasma membrane protein bacterial proteins containing the ACD domain include CorC from Salmonella typhimurium, which is involved in magnesium and cobalt efflux; R13G10.4 has no obvious function in RNAi assays. R13H4.1 R13H4.1 Protein of unknown function, has similarity to human KIAA0673 protein, isolated from a brain cDNA library R13H4.2 R13H4.2 Protein of unknown function, has moderate similarity to C. elegans T14G12.3 R13H4.3 R13H4.3 Member of the histidine acid phosphatase family, which hydrolyze phosphate esters at low pH, has low similarity to prostatic acid phosphatase (rat Ppal), which is a protein tyrosine phosphatase histidine acid phosphatase R13H4.4 hmp-1;R13H4.4 Alpha-catenin; cell junction protein required for body elongation and normal leading-cell migration and adhesion during embryonic ventral closure alpha-catenin R13H4.5 R13H4.5 Protein containing an F-box domain, which serve as a link between a target protein and a ubiquitin-conjugating enzyme This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins. R13H4.6 R13H4.6 Protein with moderate similarity to C. elegans F43E2.10 gene product ATP-dependent protease R13H4.7 R13H4.7 Protein of unknown function R13H7.1 R13H7.1 Protein of unknown function, has high similarity to uncharacterized C. elegans F31F4.3, which is predicted to be a G protein-coupled receptor 7TM chemoreceptor, srx family R13H7.2 srq-6;R13H7.2 Member of the rhodopsin family of G-protein coupled receptors (GPCR), has low similarity to uncharacterized C. elegans SRQ-3 R13H8.1 daf-16;daf-17;R13H8.2;R13H8.1 Transcription factor of the HNF-3/forkhead family; involved in control of multiple processes including dauer larva formation, longevity, and fertility daf-16 encodes a transcription factor of the HNF-3/forkhead family (orthologous to mammalian AFX, FKHR, and FKHRL1) that acts in an insulin-mediated pathway to affect dauer formation, and that also affects life span and reproduction; DAF-16 can interact with CBP-1 in vitro, and interacts genetically both with other genes in the insulin signaling and with the nuclear hormone receptor DAF-12; daf-16 is broadly expressed in most if not all cells (though expression in the pharynx and in the somatic gonad differ for the two isoforms); DAF-16 is homologous to human FORKHEAD BOX O1A (FOXO1A), which when mutated leads to rhabdomyosarcoma (OMIM:136533). R13H9.1 R13H9.1 Protein of unknown function, has very strong similarity to uncharacterized C. elegans B0491.3 R13H9.2 msp-57;R13H9.2 Member of the major sperm-specific protein (MSP) family major sperm protein (MSP-57); msp-57 encodes a member of the major sperm protein family. R13H9.4 msp-53;R13H9.4 Sperm-specific protein involved in sperm motility, member of the major sperm protein (MSP) family major sperm protein (MSP-53); msp-53 encodes a protein that belongs to a family of proteins called the Major Sperm Proteins (MSPs) that is conserved in nematodes; this family consists of closely related, small, basic proteins that make up 15% of sperm protein; this multigene family consists of over fifty genes, including many pseudogenes; MSPs are involved in both extracellular signaling and cytoskeletal functions during reproduction-MSP antagonizes Eph/ephrin signaling, in part, by binding VAB-1 Eph receptor tyrosine kinase on oocytes and sheath cells to promote oocyte maturation and MAPK activation; MSPs assemble into fibrous networks that drive movement of the C. elegans sperm; msp genes are expressed only in late primary spermatocytes. R13H9.5 R13H9.5 Serine/threonine protein kinase of the casein kinase I subfamily, has similarity to S. cerevisiae Yck1p and Yck2p casein kinase I isoforms R13H9.6 R13H9.6 Protein containing a protein kinase domain, has low similarity to C. elegans Y106G6E.6, which is a serine-threonine protein kinase that plays a role in embryogenesis and morphogenesis R144.1 klp-6;R144.1 Protein containing a kinesin motor domain, which binds ATP and microtubules, has a region of moderate similarity to a region of mouse Kif1a, which is a neuronal kinesin motor protein that transports synaptic vesicle proteins klp-6 encodes a predicted monomeric kinesin and member of the UNC-104 family. R144.10 R144.10 Protein of unknown function R144.11 R144.11 Protein of unknown function R144.2 R144.2 Protein of unknown function R144.3 R144.3 Protein of unknown function This gene encodes a protein predicted by Eisenberg and coworkers, with 52% accuracy, to be mitochondrial. R144.4 R144.4 Protein containing two Wiskott Aldrich syndrome homology region 2 (WH2) domains R144.5 R144.5 Protein of unknown function R144.6 R144.6 Putative ortholog of C. elegans W02D3.4 gene product R144.7 R144.7 Protein with moderate similarity to C. elegans T12F5.5 gene product R144.9 R144.9 Protein of unknown function R148.1 R148.1 Protein of unknown function R148.2 R148.2 Protein of unknown function R148.3 R148.3 Protein of unknown function, has a region of weak similarity to a region of heavy polypeptide of neurofilament (mouse Nfh), which is a structural protein that may regulate axonal caliber, synaptic transmission, and type IV intermediate filament assembly R148.4 R148.4 Protein of unknown function R148.5 R148.5 Protein of unknown function R148.6 R148.6 Member of the E1 family, which include allergens R148.7 R148.7 Protein of unknown function R151.1 R151.1 Protein of unknown function R151.10 R151.10 Protein of unknown function R151.2 R151.2 Protein with strong similarity to phosphoribosyl pyrophosphate synthetase subunit 2 (rat Prps2), which associates with rat Prps1 in aggregates that generate PRPP for the initiation of purine biosynthesis, contains four phosphoribosyl transferase domains Ribose-phosphate pyrophosphokinase R151.3 R151.3 Member of the ribosomal protein L6 protein family Ribosomal protein ML16; rpl-6 encodes a large ribosomal subunit L6 protein. R151.4 R151.4 Protein containing a protein kinase domain, has moderate similarity to a region of fibroblast growth factor receptor 1 (human FGFR1), which is a fibroblast growth factor receptor tyrosine kinase involved in cell proliferation and skeletal development Tyrosine kinase R151.5 toh-2;R151.5 Member of the astacin (M12A) family of metalloproteases, contains a CUB domain and a type 1 thrombospondin domain, has low similarity to C. elegans HCH-1, which is a putative zinc-dependent metalloprotease Zinc metalloprotease R151.6 R151.6 Protein with weak similarity to S. cerevisiae Der1p, which is involved in degradation of misfolded soluble proteins in the endoplasmic reticulum R151.8 R151.8 Protein is GS1-like and may have phosphatase function, strong similarity to the N-terminal region of H. sapiens GS1 (Hs.78991) R151.9 R151.9;3H288 Putative prefoldin subunit 5 (component of the Gim complex that facilitates formation of tubulin), has similarity to human PFDN5 and S. cerevisiae Gim5p R153.1 R153.1 Protein with high similarity to phosphodiesterase 4D (rat Pde4d), which is a cAMP-specific phosphodiesterase that is sensitive to the antidepressant rolipram and affects cellular cAMP levels, member of the 3',5'-cyclic nucleotide phosphodiesterase family cyclic nucleotide phosphodiesterase R153.2 R153.2 Protein of unknown function R155.1 R155.1 Member of the membrane bound O-acyl transferase (MBOAT) family, which are found in acyltransferase enzymes, has low similarity to uncharacterized mouse Grcc3f R155.2 R155.2 Member of the protein-tyrosine phosphatase family, which are involved in cell growth, proliferation, differentiation and transformation, contains a WSN domain of unknown function, has moderate similarity to uncharacterized C. elegans Y22D7AR.2 R155.3 R155.3 Member of the protein-tyrosine phosphatase family, has a region of weak similarity to a region of protein tyrosine phosphatase receptor type C (mouse Ptprc), which is a receptor tyrosine phosphatase that plays a role in signal transduction R155.4 R155.4 Protein containing two WSN domains of unknown function, has moderate similarity to uncharacterized C. elegans H04J21.1 R160.1 dpy-23;apm-2;CEAP50;R160.1 Member of the clathrin-associated protein family clathrin coat assembly protein; The dpy-23 gene encodes an adaptin: specifically, it encodes an ortholog of the mu2 subunit of adaptor protein complex 2 (AP-2). R160.2 R160.2 Protein of unknown function R160.3 R160.3 Protein of unknown function R160.4 R160.4 Protein of unknown function R160.5 R160.5 Protein of unknown function R160.6 R160.6 Protein of unknown function R160.7 R160.7 Protein containing a FYVE zinc finger domain, which bind phosphatidylinositol 3-phosphate, has a region of moderate similarity to a region of rab4-interacting protein (mouse Rab4ip), which helps to induce enlargement of early endosomal structures R166.1 R166.1 Protein with moderate similarity to human transcriptional regulatory protein p54 (Hs.171510, isolated from cell-line KG1) and murine transcriptional regulatory proteins NAB1 and NAB2 drop9 R166.2 R166.2 Protein with moderate similarity to cleft lip and palate associated transmembrane protein 1 (mouse Clptm1), which is an antigen found on the surface of thymic epithelial cells that plays a role in T cell development R166.3 R166.3 Member of the DUF51 family of unknown function, has moderate similarity to uncharacterized S. pombe Spac688.03cp The R166.3 gene encodes an unfamiliar protein, with homologs in yeast and archaea, that is orthologous to the human gene ALPORT SYNDROME, MENTAL RETARDATION, MIDFACE HYPOPLASIA, AND ELLIPTOCYTOSIS CHROMOSOMAL REGION GENE 1 (AMMECR1; OMIM:300195); AMMECR1, when mutated, may be at least partially responsible for mental retardation, midface hypoplasia, or elliptocytosis. R166.4 R166.4 Protein containing three WD domains (WD-40 repeat), which may mediate protein-protein interactions R166.5 R166.5 Protein containing a protein kinase domain, has a region of moderate similarity to MAP kinase-interacting serine-threonine kinase 1 (human MKNK1), which is a kinase activated by the ERK and p38 MAP kinase signaling pathways serine/threonine kinase R17.1 R17.1 Protein containing an F-box domain, which serve as a link between a target protein and a ubiquitin-conjugating enzyme, has moderate similarity to uncharacterized C. elegans T27E9.8 This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins; its encoded protein also contains a Pfam-B45 motif of presently unknown function. R17.2 R17.2 Protein of unknown function, has a region of weak similarity to a region of S. cerevisiae Ccr4p, which is a component of the CCR4 transcriptional complex and a component of the major cytoplasmic mRNA deadenylase R17.3 R17.3 Protein containing a type 1 thrombospondin domain Thrombospondin type 1 domain R173.1 R173.1 Member of the eukaryotic-type carbonic anhydrase protein family carbonic anhydrase; cah-5 encodes a member of the carbonic anhydrase family. R173.2 R173.2 TcA transposase transposase R173.3 R173.3 Member of the carboxylesterase type B family, has low similarity to butyrylcholinesterase (human BCHE), which is associated fluoride resistance and acholinesterasemia upon gene mutation and the K variant is implicated in late-onset Alzheimer's disease esterase R186.1 R186.1 Protein of unknown function, has high similarity to uncharacterized C. elegans Y80D3A.9 R186.2 R186.2 G protein-coupled receptor, member of a subfamily with SRD proteins which are expressed in chemosensory neurons, no homolog found in human or D. melanogaster R186.3 R186.3 Protein with low similarity to signal recognition particle receptor subunit B (mouse Srprb), which mediates signal sequence release from the signal recognition particle and may be required for the association of the receptor alpha subunit with the ER signal recognition particle receptor beta subunit like R186.4 lin-46;R186.4 Member of the molybdenum cofactor biosynthesis protein family, has low similarity to a region of gephyrin (human GPHN), which is a tubulin binding protein that mediates clustering of GABA and glycine receptors and is an autoantigen in Stiff Man Syndrome gephyrin like R186.5 shw-3;R186.5 Protein with high similarity to C. elegans EGL-36, which is a voltage-sensitive potassium channel, contains a K+ channel tetramerization domain, which aid assembly of alpha-subunits into functional tetrameric channels, member of the ion transport family potassium channel protein; This gene encodes a protein predicted by Eisenberg and coworkers, with 52% accuracy, to be mitochondrial. R186.6 R186.6 Protein containing a rhodanese-like domain, has low similarity to mercaptopyruvate sulfotransferase (3-mercaptopyruvate sulfotransferase, rat Rn.32263), which catalyzes the transfer of a sulfur ion from mercaptopyruvate to mercaptoethanol Rhodanese-like domain R186.7 R186.7 Protein of unknown function R193.2 R193.2 Protein with weak similarity to H. sapiens COL6A3 (collagen, type VI, alpha 3) R193.3 R193.3 Protein of unknown function R31.1 sma-1;sma-7;sma1;R31.1 Putative spectrin, contains putative CH (calponin homology) and spectrin domains, has strong similarity to D. melanogaster beta-spectrin and is apparently required for embryonic elongation spectrin beta chain R31.2 R31.2 Protein containing one ankyrin (Ank) repeat, which may mediate protein-protein interactions ankyrin motif R31.3 osm-6;R31.3 Protein required in many ciliated neurons for growth of distal parts of the axonemes; required for normal osmotic avoidance, chemotaxis, dauer larvae formation, and mechanosensation N-acetyllactosamine synthase; osm-6 males are defective in their response to hermaphrodite-derived diffusible cues. R52.1 R52.1 Protein containing one meprin and TRAF homology (MATH) domain and one BTB (BR-C, ttk and babor) or POZ (Pox virus and zinc finger) domain, which are found in some DNA and actin binding proteins, has high similarity to uncharacterized C. elegans R52.10 R52.10 R52.10 Protein containing two meprin and TRAF homology (MATH) domains, has high similarity to uncharacterized C. elegans R52.1 R52.2 R52.2 Putative ortholog of C. elegans W03H1.1 gene product R52.3 R52.3 Protein containing three meprin and TRAF homology (MATH) domains, has high similarity to uncharacterized C. elegans C46F9.3 R52.4 R52.4 Protein of unknown function, has moderate similarity to uncharacterized C. elegans K07G6.1 R52.5 R52.5 Protein containing a DUF130 domain of unknown function, has high similarity to uncharacterized C. elegans F07E5.7 R52.6 R52.6 Protein containing a DUF130 domain of unknown function R52.7 R52.7 Member of the 7-transmembrane chemoreceptor family of G-protein coupled receptors (GPCR), has high similarity to uncharacterized C. elegans F47D2.9 7TM chemoreceptor, srh family R52.8 R52.8 Protein containing two meprin and TRAF homology (MATH) domains, has high similarity to uncharacterized C. elegans C16C4.14 R52.9 R52.9 Protein containing a meprin and TRAF homology (MATH) domain, has moderate similarity to uncharacterized C. elegans C16C4.3 R53.1 R53.1 Protein of unknown function, has strong similarity to human Hs.118666 gene product (isolated from an infant brain cDNA library) FAD-1 like protein R53.2 R53.2 Member of the thymidylate kinase family, which phosphorylate thymidine 5'-monophosphate, has moderate similarity to deoxythymidylate kinase (dTMP kinase, human DTYMK), which phosphorylates dTMP to dTDP in dTTP biosynthesis thymidylate kinase R53.3 egl-43;R53.3 Zinc finger containing protein involved in development of phasmid and hermaphrodite-specific neurons Zinc finger, C2H2 type (2 domains); egl-43 encodes a zinc finger protein that affects HSN cell migration and development of the phasmid neurons; expressed in the HSN and phasmid neurons. R53.4 R53.4 Protein of unknown function, has weak similarity to human F1Fo-ATPase synthase f subunit ATP5JL ATP synthase complex f subunit like protein R53.5 R53.5 Protein of unknown function R53.6 R53.6 Protein of unknown function, has moderate similarity to uncharacterized human KIAA0186 R53.7 R53.7 Protein containing three CBS (cystathionine-beta-synthase) domains, has a region of weak similarity to a region of AMP-activated protein kinase gamma 3 (human PRKAG3), which is a protein kinase regulatory subunit and serves in energy homeostasis protein kinase like protein R53.8 R53.8 Protein of unknown function R57.1 R57.1 Protein containing two PA (protease associated) domains, has moderate similarity to folate hydrolase 1 (rat Folh1), which is an enzyme with folate hydrolase and N-acetylated alpha-linked acidic dipeptidase activity trans-membrane protein R57.2 R57.2 Protein containing a DB module domain R74.1 R74.1 Member of the class I isoleucyl, leucyl, valyl, and methionyl (I, L, M, and V) tRNA synthetase family, has moderate similarity to C. albicans Cdc60p, which is a leucine tRNA ligase leucyl-tRNA synthetase; lrs-1 encodes a predicted cytoplasmic leucyl-tRNA synthetase (LeuRS), a class I aminoacyl-tRNA synthetase that catalyzes the attachment of leucine to its cognate tRNA and is thus required for protein biosynthesis; LRS-1 activity is required for embryonic, larval, and germline development, as well as normal body morphology and rates of postembryonic growth. R74.2 R74.2 Protein of unknown function R74.3 xbp-1;R74.3 Putative X-box DNA-binding protein, involved in the ER-overload response and the unfolded protein response X box DNA binding protein-1; xbp-1 encodes a bZIP transcription factor orthologous to yeast Hac1 and mammalian X box-binding protein 1 (XBP-1, OMIM:194355); XBP-1 is required for the unfolded protein response (UPR) that counteracts cellular stress induced by accumulation of unfolded proteins in the endoplasmic reticulum (ER); XBP-1 mRNA is spliced by the IRE-1 endoribonuclease to promote translation of transcriptionally active XBP-1 that positively regulates UPR gene expression to maintain ER homeostasis and promote normal development. R74.4 R74.4 Protein containing a DnaJ domain, which are part of chaperone (protein folding) system that mediates interaction with heat shock proteins, has a region of high similarity to a region of DnaJ subfamily A member 3 (HSP40, human DNAJA3) DNAJ domain; This gene encodes a protein containing a DnaJ ('J') domain. R74.5 R74.5 Protein containing an RNA recognition motif (RRM, RBD, or RNP), has moderate similarity to C. elegans FOX-1, which is an RNA-binding protein involved in establishment or assessment of the X:A ratio for sex determination and dosage compensation RNA binding protein; R74.5 encodes a putative RNA-binding protein, with both an RNA recognition motif and a glutamine/asparagine-rich domain. R74.6 R74.6 Member of the eukaryotic release factor 1 (eRF1) family, which are involved in translation termination, has low similarity to S. cerevisiae Dom34p, which is involved in protein translation DOM34 protein R74.7 R74.7 Member of a protein family R74.8 R74.8 Protein with strong similarity to C. elegans M70.5 gene product R90.1 R90.1 Protein containing a protein kinase domain, has a region of low similarity to putative casein kinase I (CKI, S. pombe Hhp1p), which is required for DNA repair casein Kinase I R90.2 R90.2 Member of the transthyretin-like family, has high similarity to uncharacterized C. elegans F36A4.8 Transthyretin-like family R90.3 R90.3 Member of the transthyretin-like family, has high similarity to uncharacterized C. elegans R90.4 Transthyretin-like family R90.4 R90.4 Member of the transthyretin-like family, has high similarity to uncharacterized C. elegans R90.3 Transthyretin-like family RAD-9 rad-9 Putative homolog of H. sapiens Rad9 cell cycle checkpoint protein RNH2 rnh2 Putative ribonuclease H2 large subunit SLO-1 slo-1 Calcium-activated potassium channel; required for a normal rate of embryonic development SOC-1 soc-1 Suppressor of clr-1; a multisubstrate adaptor protein involved in FGF signaling SSSD1.1 SSSD1.1 Protein containing three immunoglobulin (Ig) domains and a fibronectin type III domain, which are involved in cell surface binding, has a region of weak similarity to a region of plasmacytoma-associated neuronal glycoprotein (rat Pang) neural cell adhesion protein STH-1 sth-1 Protein of unknown function STR-145 str-145 Chemoreceptor SYN syn Synapsin, member of a family of vertebrate and invertebrate neuron-specific phophoproteins concentrated at synapses T01A4.2 T01A4.B;T01A4.2 Protein with strong similarity to C. elegans T01A4.1 gene product T01A4.A T01A4.3;T01A4.A Putative ortholog of C. elegans Y47H9C.9 gene product T01A4.E T01A4.1;T01A4.E Protein containing six adenylate and guanylate cyclase catalytic domains, four protein kinase domains, and two receptor family ligand binding domains, has moderate similarity to natriuretic peptide receptor A (mouse Npr1), which is a guanylate cyclase T01B10.1 grd-4;T01B10.1 Protein of unknown function, has strong similarity to C. elegans GRD-3 grd-4 encodes a member of the C. elegans hedgehog-like family and contains a DUF398 domain, a domain thus far unique to C. elegans. T01B10.2 grd-14;T01B10.2 Protein of unknown function, has strong similarity to C. elegans GRD-3 T01B10.4 nhr-14;T01B10.4 Member of the nuclear hormone receptor/Zinc finger protein family, similar to mammalian HTF-1alpha nuclear hormone receptor T01B10.5 T01B10.5 Protein of unknown function T01B11.1 T01B11.1 Protein of unknown function, has low similarity to uncharacterized C. elegans C04C3.6 T01B11.2 T01B11.2 Member of the aminotransferase class III pyridoxalphosphate-dependent enzyme family, has moderate similarity to beta-alanine-pyruvate aminotransferase (rat Agt2), which acts in transamination and defluorination and is inhibited by chemotherapeutic agents aminotransferase T01B11.3 syn-4;T01B11.3 Member of the syntaxin protein family syntaxin; syn-4 encodes a Type-I transmembrane protein that is orthologous to mammalian Syntaxin 1, a t-SNARE (soluble N-ethylmaleimide-sensitive factor attachment protein (SNAP) receptor); by homology, SYN-4 is predicted to function as a receptor for intracellular transport vesicles during membrane fusion reactions; in C. elegans, SYN-4 activity is essential for three aspects of early embryogenesis: polar body extrusion, cytokinesis, and nuclear envelope reassembly following mitosis; in addition, SYN-4 may also play a role in formation of the vitelline membrane and/or eggshell; SYN-4 is expressed in the outer membrane of the early embryo, in a punctate pattern around reforming nuclear envelopes, and at the cleavage furrow during ingression; in L1 larvae, SYN-4 is expressed at high levels in lateral seam cells, and in adult hermaphrodites SYN-4 localizes to the incomplete membranes that separate germline nuclei in the gonad. T01B11.4 T01B11.4 Protein with high similarity to solute carrier family 25 member 4 (mouse Slc25a4), which is an adenine nucleotide translocator that functions in metabolism and apoptosis, member of the mitochondrial carrier protein family of membrane transporters ADP/ATP translocase T01B11.7 oat-1;T01B11.6;T01B11.7 Member of the sugar (and other) transporter family, has low similarity to human SLC22A5, which is a sodium-dependent carnitine transporter that provides carnitine for fatty acid beta-oxidation transmembrane transporter; oat-1 encodes a transmembrane organic anion transporter; although loss of oat-1 activity via large-scale RNAi screens results in no obvious abnormalities, when expressed in mammalian cells OAT-1 can transport a variety of structurally diverse organic anions via an anion exchange mechanism that is functionally coupled to a sodium-coupled dicarboxylate transporter; by homology with mammalian OAT1 transporters, C. elegans OAT-1 is predicted to function in xenobiotic elimination. T01B4.1 twk-16;T01B4.1 Member of the 4 TM potassium channel protein family potassium channel protein T01B4.2 twk-17;T01B4.2 Member of the 4 TM potassium channel protein family potassium channel protein like T01B6.1 T01B6.1 Protein of unknown function T01B6.3 T01B6.3 Protein with similarity to human and D. melanogaster AMP-activated protein kinase gamma subunits T01B6.4 T01B6.4 Protein of unknown function T01B7.1 T01B7.1 Member of the C. elegans Srg family of integral membrane proteins, which may be involved in chemosensation T01B7.2 T01B7.2 Member of the C. elegans Srg family of integral membrane proteins, which may be involved in chemosensation, has moderate similarity to uncharacterized C. elegans F15A4.4 T01B7.3 T01B7.3 Member of the Ras superfamily of GTP binding proteins, has moderate similarity to Ras-related GTP-binding protein 5C (human RAB5C), which is a putative GTPase involved in endosome to lysosome transport ras-related protein T01B7.4 cyp-11;T01B7.4 Cyclophilin-related peptidylprolyl cis-trans-isomerase peptidyl-prolyl cis-trans isomerase; cyp-11 encodes a divergent cyclophilin D isoform, with alterations in the normally well-conserved cyclophilin-binding domain, and a central 7-8 residue insert not usually found in cyclophilins, except from plants; CYP-11 has sluggish but detectable peptidyl-prolyl isomerase activity in vitro, suggesting that it has a specialized substrate in vivo; CYP-11 is dispensable for viability and gross morphology in mass RNAi screens. T01B7.5 T01B7.5 Protein of unknown function T01B7.6 T01B7.6 Protein of unknown function T01B7.7 rol-6;T01B7.7 Member of the collagen triple helix repeat (20 Copies) protein family cuticle collagen ROL-6; The rol-6 gene encodes a cuticle collagen related to human collagen alpha 1 (III) chain precursor (OMIM:120180), and is required for normal cuticular morphology; ROL-6 interacts with SQT-1, a closely related cuticle collagen, and is expressed at all stages from L2 to adult with transcripts detected at each of the molts preceding these stages. T01B7.8 T01B7.8 Protein of unknown function, has weak similarity to C. elegans C27A2.5 T01C1.1 T01C1.1 Protein of unknown function, has high similarity to uncharacterized C. elegans C17B7.6 T01C1.2 T01C1.2 Protein of unknown function T01C1.3 T01C1.3 Protein of unknown function T01C2.1 T01C2.1 Protein with strong similarity to C. elegans acy-2 gene product acy-4 encodes an adenylate cyclase most similar to vertebrate type V and type VI adenylate cyclases; by homology, ACY-4 is a predicted plasma membrane protein that catalyzes the conversion of ATP to cyclic AMP, a key second messenger in intracellular signaling; as loss of acy-4 activity via large-scale RNAi screens does not result in any obvious abnormalities, the precise role of ACY-4 in C. elegans development and/or behavior is not yet known. T01C3.1 T01C3.1 Protein containing seven WD domains (WD-40 repeat), which may mediate protein-protein interactions WD domain, G-beta repeats T01C3.10 nmr-2;T01C3.10 Protein containing a ligand-gated ion channel domain, which are found in ionotropic glutamate receptors and NMDA receptors, has low similarity to rat Grin1, which is a major subunit of the N-methyl-D-aspartate (NMDA) glutamate receptor glutamate receptor subunit epsilon T01C3.2 T01C3.2 Protein of unknown function T01C3.3 T01C3.3 Protein containing a C3HC4 type (RING) zinc finger, which may mediate protein-protein interactions, has low similarity to uncharacterized C. elegans Y45F10B.8 Zinc finger, C3HC4 type (RING finger) T01C3.4 T01C3.4 Member of the class 2 lipase family, has high similarity to uncharacterized C. elegans K12B6.3 lipase T01C3.5 T01C3.5 Protein with moderate similarity to C. elegans T06E4.5 gene product T01C3.6 rps-16;T01C3.6 Protein with high similarity to ribosomal protein S16 (S. cerevisiae Rps16bp), which is a ribosomal structural protein, contains a ribosomal S9 or S16 domain, which are present in the small ribosomal subunit 40S ribosomal protein S16; rps-16 encodes a small ribosomal subunit S16 protein. T01C3.7 T01C3.7 Member of the fibrillarin protein family fibrillarin T01C3.8 T01C3.8 Protein of unknown function T01C3.9 T01C3.9 Protein of unknown function, has weak similarity to C. elegans F43C11_37.B T01C4.1 T01C4.1 Member of the glycosyl hydrolase 18 family, contains three LysM domains, which may bind peptidoglycans, has a region of low similarity to chitinase 1 (human CHIT1), which catalyzes the hydrolysis of chitin and may play a role in response to pathogens glycosyl hyrolase T01C4.2 odr-2;T01C4.2 Protein involved in AWC-mediated chemosensation of volatile odorants odr-2 encodes three isoforms of a predicted membrane-associated protein related to the Ly-6 (leukocyte antigen-6) family of GPI (glycosylated phosphatidylinositol)-linked signaling proteins; ODR-2 activity is required for proper functioning of the AWC olfactory neurons and thus for chemotaxis in response to AWC-sensed odorants; ODR-2 is expressed at high levels in sensory neurons, motor neurons, and interneurons, where it appears to be enriched in axons. T01C4.3 T01C4.3 Protein of unknown function, has low similarity to uncharacterized C. elegans K09D9.10 7TM chemoreceptor, srx family T01C4.4 T01C4.4 Member of the rhodopsin family of G-protein coupled receptors (GPCR), has low similarity to uncharacterized C. elegans K09D9.10 7TM chemoreceptor, srx family T01C4.5 T01C4.5 Protein of unknown function, has low similarity to uncharacterized C. elegans K09D9.10, which is a putative G-protein coupled receptor (GPCR) 7TM chemoreceptor, srx family T01C4.6 T01C4.6 Member of the rhodopsin family of G-protein coupled receptors (GPCR), has low similarity to uncharacterized C. elegans K09D9.10 7TM chemoreceptor, srx family T01C8.1 T01C8.1 Protein with high similarity to catalytic alpha 2 subunit of the 5'-AMP-activated protein kinase (rat Prkaa2), which is a metabolic sensor of AMP levels that is involved in fatty acid beta-oxidation and glucose transport, contains a protein kinase domain ser/thr-protein kinase T01C8.2 T01C8.2 Protein of unknown function, has high similarity to uncharacterized C. elegans R10H10.4 T01C8.3 T01C8.3 Protein of unknown function T01C8.4 T01C8.4 Protein containing an aminotransferase class I and II domain, has moderate similarity to soluble glutamate-oxaloacetate transaminase (cytosolic aspartate aminotransferase, human GOT1), which transaminates 2-oxoglutarate and may be an indicator of hepatoma aminotransferase T01C8.5 T01C8.5 Protein with high similarity to soluble glutamate-oxaloacetate transaminase (cytosolic aspartate aminotransferase, mouse Got1), which transaminates 2-oxoglutarate, contains an aminotransferase class I and II domain aminotransferase T01C8.7 mec-4;mec-13;T01C8.7 Member of the amiloride-sensitive sodium channel family, member of the degenerin family and DEG/ENaC superfamily of proteins mec-4 encodes an amiloride-sensitive Na+ channel protein (degenerin) required to sense gentle mechanical stimuli (e.g. touch) along the body wall; MEC-4 is paralogous to, and coexpressed with, MEC-10, in all six touch cell neurons where they form a heteromeric mechanotransduction channel. T01D1.1 T01D1.1 Protein of unknown function T01D1.2 etr-1;T01D1.2 Putative RNA-binding protein with high similarity to human CUG triplet repeat-binding protein NAB50 (Hs.81248, involved in myotonic dystrophy); has similarity to D. melanogaster BRUNO and ARET (arrest) RNA-binding protein; etr-1 encodes a muscle-specific ELAV-type RNA-binding protein, whose homologs include Drosophila ELAV and human CUG-BINDING PROTEIN (CUGBP1; OMIM:601074); etr-1 function is required for embryonic muscle development, which suggests that ETR-1's homology to CUG-BP (implicated in myotonic dystrophy) might reflect conserved roles in development. T01D1.3 T01D1.3 Protein of unknown function T01D1.4 T01D1.4 Member of the acireductone dioxygenase family, has moderate similarity to uncharacterized human SIPL T01D1.5 T01D1.5 Protein of unknown function, has weak similarity to C. elegans C42D4.9 T01D1.6 T01D1.6 Protein containing eight uncharacterized DUF139 cysteine repeat domains abu-11 encodes a transmembrane protein with a predicted signal sequence, a glutamine/asparagine-rich domain and multiple cysteine-rich repeats (DUF139); abu-11 expression is induced by blockage of the unfolded-protein response in the endoplasmic reticulum, and ABU-11 may help protect the organism from damage by improperly folded nascent protein. T01D3.1 T01D3.1 Protein containing three epidermal growth factor (EGF)-like domains, has a region of low similarity to a region of tenascin C (human HXB), which is a multidomain extracellular matrix glycoprotein that may be involved in cell adhesion EGF-like domains T01D3.2 T01D3.2 Protein with strong similarity to mammalian and D. melanogaster SINGLE-MINDED (SIM) proteins, transcriptional regulators of the basic helix-loop-helix (bHLH)-PAS family (GenBank)] single minded protein T01D3.3 T01D3.3 Member of the copper-zinc superoxide dismutase family, which convert superoxide into molecular oxygen and hydrogen peroxide, contains two thyroglobulin type-1 repeats and 12 trypsin inhibitor-like cysteine rich domains Von Willebrand factor-like T01D3.4 T01D3.4 Protein of unknown function, has low similarity to uncharacterized C. elegans F09F3.13 somatostatin receptor T01D3.5 T01D3.5 Protein with weak similarity to S. cerevisiae Atx2p (a manganese-trafficking protein), has weak similarity to C. elegans T28F3.3 T01D3.6 T01D3.6 Protein containing a beta or gamma fibrinogen C-terminal globular domain, a trypsin inhibitor-like cysteine rich domain, and a von Willebrand factor (vWF) type D domain, has a region of low similarity to a region of igGFc binding protein (human FCGBP) EGF-like domain, Fibrinogen beta and gamma chains, C-terminal globular domain T01E8.1 T01E8.1 Protein with weak similarity to S. cerevisiae GRR1 (F-box protein that targets G1 cyclins and Gic1p and other proteins for degradation by the SCF-Grr1p complex (Skp1p-Cdc53p-Cdc34p-Grr1p)) T01E8.2 ref-1;T01E8.2 Contains two basic helix-loop-helix domains; regulates Pn.p cell fusion and lin-39 expression Helix-loop-helix DNA-binding domain (2 domains); ref-1 encodes a protein with two basic helix-loop-helix (bHLH) domains that is distantly related to the hairy/Enhancer of split subfamily of bHLH transcription factors; REF-1 is required in hermaphrodites during early larval development for regulating the pattern of posterior Pn.p hypodermal cell fusions, primarily through regulation of MAB-5 homeodomain protein activity; REF-1 is also required for head morphogenesis and specification of the V6 lateral seam cell fate. | ref-1 encodes a protein with two basic helix-loop-helix (bHLH) domains that is distantly related to the hairy/Enhancer of split subfamily of bHLH transcription factors; REF-1 is required in hermaphrodites during early larval development for regulating the pattern of posterior Pn. T01E8.3 T01E8.3 Protein containing Src homology 2 (SH2) domains, Src homology 3 (SH3), C2, and pleckstrin homology (PH) domains, and phosphatidylinositol-specific phospholipase C X and C Y domains, has moderate similarity to phospholipase C gamma 1 (human PLCG1) 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase T01E8.4 T01E8.4 Protein containing five WD domains (WD-40 repeat), which may mediate protein-protein interactions, and an F-box domain, which serve as a link between a target protein and a ubiquitin-conjugating enzyme WD domain, G-beta repeats; This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins; its encoded protein also contains WD repeats. T01E8.5 T01E8.5 Protein of unknown function T01E8.6 T01E8.6 Possible mitochondrial small ribosomal subunit protein mitochondrial ribosomal protein S14 T01E8.7 T01E8.7 Protein of unknown function, has strong similarity to C. elegans F37B4.4 G-protein coupled receptor, srh family T01G1.1 klp-12;T01G1.1 An anterograde N-terminal kinesin apparently required for chromosomal segregation kinesin, kinesin-4 family T01G1.2 T01G1.2 Protein of unknown function T01G1.3 T01G1.3 Protein with strong similarity to S. cerevisiae Sec31p, a component (p150) of COPII coat of secretory pathway vesicles involved in endoplasmic reticulum to Golgi transport Yesat transport protein WEB1 like T01G5.1 T01G5.1 Protein containing a protein kinase domain, has moderate similarity to C. elegans KIN-15, which is a putative receptor tyrosine protein kinase tyrosine-protein kinase (KIN15/KIN16 subfamily) T01G5.2 T01G5.2 Protein containing a UDP-glucoronosyl and UDP-glucosyl transferase domain, has weak similarity to UDP-glycosyltransferase 1 A9 (human UGT1A9), which converts hydrophobic xenobiotic and endobiotic compounds to hydrophilic compounds for removal from cell UDP-glucuronysltransferase T01G5.3 T01G5.3 Member of the 7-transmembrane chemoreceptor family of G-protein coupled receptors (GPCR), has weak similarity to C. elegans ODR-10, which is involved in odorant response T01G5.4 T01G5.4 Protein of unknown function, has high similarity to uncharacterized C. elegans C13D9.3 T01G5.5 T01G5.5 Member of the 7-transmembrane chemoreceptor family of G-protein coupled receptors (GPCR), has low similarity to C. elegans ODR-10, which is involved in odorant response 7TM receptor T01G5.6 T01G5.6 Protein with moderate similarity to C. elegans T23D5.7 gene product T01G5.7 T01G5.7 Protein containing a C3HC4 type (RING) zinc finger, which may mediate protein-protein interactions, has moderate similarity to uncharacterized C. elegans Y45F10B.9 Zinc finger, C3HC4 type (RING finger) T01G6.1 T01G6.1 Member of the alcohol/ribitol dehydrogenase-like protein family dehydrogenase; This gene encodes a protein predicted by Eisenberg and coworkers, with 68% accuracy, to be mitochondrial. T01G6.10 T01G6.10 Member of the short-chain dehydrogenase-reductase family, which are NAD- or NADP-dependent oxidoreductases, has low similarity to 1,3,6,8-tetrahydroxynaphthalene reductase (A. fumigatus Arp2), which is involved in conidial pigment biosynthesis dehydrogenase; This gene encodes a protein predicted by Eisenberg and coworkers, with 68% accuracy, to be mitochondrial. T01G6.2 nhr-C;T01G6.2 Protein containing two nuclear hormone receptor C4-type zinc finger domains, which bind DNA and may be involved in regulation of transcription, has moderate similarity to C. elegans NHR-58, which is involved in embryogenesis and morphogenesis zinc finger protein T01G6.3 T01G6.3 Member of the 7-transmembrane chemoreceptor family of G-protein coupled receptors (GPCR), has high similarity to uncharacterized C. elegans STR-2 7TM chemoreceptor, str family T01G6.4 nhr-E;T01G6.4 Protein containing two nuclear hormone receptor C4-type zinc finger domains, has moderate similarity to C. elegans NHR-58, which may be involved in embryogenesis and morphogenesis zinc finger protein T01G6.5 T01G6.5 Protein containing a nuclear hormone receptor C4-type zinc finger domain, which bind DNA and may be involved in regulation of transcription, has moderate similarity to C. elegans NHR-58, which is involved in embryogenesis and morphogenesis zinc finger protein T01G6.6 T01G6.6 Protein containing a nuclear hormone receptor C4-type zinc finger domain, which bind DNA and may be involved in regulation of transcription, has moderate similarity to C. elegans NHR-58, which is involved in embryogenesis and morphogenesis nuclear hormone receptor T01G6.7 nhr-55;T01G6.7 Member of the nuclear hormone receptor/Zinc finger protein family zinc finger protein T01G6.8 T01G6.8 Protein containing a nuclear hormone receptor C4-type zinc finger domain and a nuclear hormone receptor ligand-binding domain, has moderate similarity to C. elegans NHR-58, which is involved in embryogenesis and morphogenesis zinc finger protein T01G6.9 str-256;T01G6.9 Member of the 7-transmembrane chemoreceptor family of G-protein coupled receptors (GPCR), has weak similarity to C. elegans ODR-10, which is involved in odorant response 7TM chemoreceptor, str family T01G9.1 T01G9.1 Protein of unknown function T01G9.2 T01G9.2;lin-10;ORF1 Protein of unknown function T01G9.3 T01G9.3 Protein containing nine leucine rich repeats and a leucine rich repeat C-terminal cysteine rich domain, has a region of low similarity to a region of insulin-like growth factor binding protein acid-labile subunit (human IGFALS) leucine rich repeats T01G9.4 kup-2;T01G9.4 Protein of unknown function npp-2 encodes a protein with low similarity to rat nucleoporin Nup75 that affects embryonic viability and has a variety of other defects in RNAi screens including: nuclear morphology, growth, fertility, locomotion, and egg laying; enriched in oocytes. T01G9.5 mei-1;T01G9.5 Involved in microtubule disassembly during meiotic spindle formation and the functional homolog of H. sapiens p60 katanin MEI-1 meiotic spindle formation protein; mei-1 encodes, by alternative splicing, two slightly different isoforms of an ortholog of the catalytic subunit of katanin (OMIM:606696) that is required for oocyte meiotic spindle formation, for stable association of the meiosis I spindle with the oocyte cortex, and for microtubule severing; MEI-1 exists in a physical complex with MEI-2 at the polar ends of meiotic spindle microtubules and meiotic chromatin; MEI-1 must be inactivated for meiosis to give way to mitosis, and ectopic expression of MEI-1/MEI-2 during mitosis is normally lethal; MEI-1 is bound by the BTB protein MEL-26 (both in vivo and in vitro), which physically links MEI-1 to CUL-3 (an E3 ubiquitin ligase); CUL-3, in turn, promotes MEI-1 proteolysis by the 26S proteasome during the transition from meiosis to mitosis; the MEI-1/MEI-2 complex requires tubules containing the germline-enriched beta tubulin TBB-2 in vivo, but does not require tubules made from TBB-2's (superficially) redundant paralog TBB-1. T01G9.6 kin-10;CKIIbeta;T01G9.6 Protein with strong similarity to the casein kinase II beta polypeptide (human CSNK2B), which is a casein kinase II regulatory subunit that confers stability to catalytic subunits, member of the casein kinase II regulatory subunit (beta subunit) family KIN-10 casein kinase T01H10.1 T01H10.1 Protein containing a neurotransmitter-gated ion-channel ligand binding domain, has low similarity to a region of 5-hydroxytryptamine (serotonin) receptor 3A (human HTR3A), which is a ligand-gated ion channel that mediates many neurophysiological effects nitcotinic acetylcholine receptor T01H10.2 T01H10.2 Protein containing a neurotransmitter-gated ion-channel ligand binding domain, has low similarity to a region of 5-hydroxytryptamine 3B (serotonin) receptor subunit (rat Htr3b), which associates with subunit rat Htr3a to form ligand-gated cation channels nicotinic acetylcholine receptor T01H10.3 T01H10.3 Protein containing a neurotransmitter-gated ion-channel ligand binding domain, has low similarity to a region of 5-hydroxytryptamine (serotonin) receptor 3A (human HTR3A), which is a ligand-gated ion channel that mediates many neurophysiological effects nicotinic acetylcholine receptor T01H10.4 T01H10.4 Protein containing a protein kinase domain, has moderate similarity to uncharacterized C. elegans ZC373.3 serine/threonine kinase T01H10.5 T01H10.5 Protein containing a neurotransmitter-gated ion-channel ligand binding domain, has weak similarity to a region of 5-hydroxytryptamine (serotonin) receptor 3A (mouse Htr3a), which is a ligand-gated ion channel that mediates many neurophysiological effects nicotinic acetylcholine receptor T01H10.6 T01H10.6 Protein containing a neurotransmitter-gated ion-channel ligand binding domain, has weak similarity to a region of 5-hydroxytryptamine (serotonin) receptor 3A (human HTR3A), which is a ligand-gated ion channel that mediates many neurophysiological effects nicotinic acetylcholine receptor T01H10.7 T01H10.7 Protein containing a neurotransmitter-gated ion-channel ligand binding domain, has low similarity to a region of the neuronal nicotinic acetylcholine receptor alpha 6 subunit (human CHRNA6), which may be involved in neural synaptic transmission nicotininc acetylcholine receptor T01H10.8 T01H10.8 Protein containing one beige or BEACH domain, has a region of moderate similarity to a region of lysosomal trafficking regulator protein (mouse Lyst), which is required for vesicular transport to and from the lysosome and late endosome Yeast hypothetical protein YCR32 like T01H3.1 vha-4;T01H3.1 Putative subunit of a Vacuolar-type H+ ATPase proteolipid protein PPA1 like protein T01H3.2 T01H3.2 Protein of unknown function T01H3.3 T01H3.3 Protein of unknown function, has a region of weak similarity to a region of human SLC17A7, which is a brain-specific Na+-dependent inorganic phosphate cotransporter sodium/phosphate transporter T01H3.4 T01H3.4 Protein of unknown function T01H3.5 T01H3.5 Protein of unknown function T01H8.1 rsk-1;T01H8.1 Protein with high similarity to ribosomal protein S6 kinase 1 (human RPS6KA1), which is a mitogen activated serine-threonine protein kinase, contains two protein kinase C-terminal domains and four protein kinase domains Protein kinase C terminal domain T01H8.2 T01H8.2 Member of the pyridoxal phosphate dependent enzyme beta family, has moderate similarity to serine racemase (human SRR), which catalyzes the racemisation of L-serine to form D-serine and may mediate the synthesis of D-serine in the brain threonine dehydratase; This gene encodes a protein predicted by Eisenberg and coworkers, with 52% accuracy, to be mitochondrial. T01H8.5 gon-2;T01H8.3;T01H8.4;T01H8.5 TRP channel protein that may mediate signal transduction for gonadal growth transient receptor protein; The gon-2 gene encodes a predicted transmembrane cation channel homologous to the long transient receptor potential channel (LTRPC) subfamily of TRP channels including Drosophila DLTRP and mammalian melastatin and LTRPC7; GON-2 regulates the onset and continuation of post-embryonic mitotic cell divisions in the somatic gonad precursor cells perhaps by mediating an increase in intracellular calcium in response to activating signals. T02B11.1 T02B11.1 Protein of unknown function, has moderate similarity to uncharacterized C. elegans Y40H7A.8 7TM chemoreceptor, srg family T02B11.3 T02B11.3 Putative ortholog of C. elegans T02B11.4 gene product T02B11.4 T02B11.4 Protein of unknown function, has high similarity to uncharacterized C. elegans K09C6.9 T02B11.5 T02B11.5 Member of the 7-transmembrane chemoreceptor family of G-protein coupled receptors (GPCR), has weak similarity to C. elegans ODR-10, which is involved in odorant response 7TM chemoreceptor, srj family T02B11.6 T02B11.6 Member of the sugar (and other) transporter family, has weak similarity to solute carrier family 17 member 1 (mouse Slc17a1), which is involved in sodium-dependent phosphate transport and mediates hepatic and renal anion drug transport T02B11.7 T02B11.7 Member of the astacin (M12A) family of metalloproteases, has low similarity to C. elegans HCH-1, which is a putative zinc-dependent metalloprotease involved in cell migration and neurogenesis protease T02B5.1 T02B5.1 Member of the carboxylesterase protein family carboxylesterase T02B5.2 T02B5.2 Protein of unknown function T02B5.2 encodes a protein with an OCAM domain, a nematode-specific motif conserved between T02B5.2 and two other nematode ONECUT homeobox proteins (CEH-21 and CEH-41); this gene is probably derived from a ONECUT gene that lost both tit cut domain and its homeodomain; T02B5.2 has no obvious function in mass RNAi assays. T02B5.3 T02B5.3 Member of the carboxylesterase protein family carboxylesterase T02B5.4 T02B5.4 Protein of unknown function, has high similarity to uncharacterized C. elegans M01B2.2 T02C1.1 T02C1.1 Protein containing a C3HC4 type (RING) zinc finger, which may mediate protein-protein interactions Zinc finger, C3HC4 type (RING finger) T02C12.1 hum-5;mceIA;T02C12.1 Putative myosin myosin IA T02C12.2 tbb-2;T02C12.2 Protein with low similarity to small nuclear RNA activating complex polypeptide 3 50kD (human SNAPC3), which is a DNA binding subunit of SNAPc complex required for transcription by both RNA polymerase II and III snRNA genes T02C12.3 T02C12.3 Has low similarity to general transcription factor IIIC polypeptide 5 (human GTF3C5), which is a subunit of the DNA-binding subcomplex TFIIIC2 that may be involved in recruiting TFIIIB and RNA polymerase III to the pre-initiation complex T02C5.1 T02C5.1 Protein containing two TNFR-NGFR cysteine-rich regions, which are found in some cell surface receptors The T02C5.1 gene encodes a protein that may be involved in apoptosis; it has some similarity to the tumor necrosis factor (TNF) receptor of vertebrates. T02C5.2 T02C5.2 Protein of unknown function T02C5.3 T02C5.3 Protein containing two immunoglobulin (Ig) domains, which may be involved in protein-protein and protein-ligand interactions T02C5.4 T02C5.4 Protein of unknown function T02C5.5 unc-2;T02C5.5 Putative subunit of a voltage-dependent calcium channel required for coordinated movement unc-2 encodes a calcium channel alpha subunit required for desensitization to dopamine, normal flexion and speed during movement, normally low sensitivity of whole animals to serotonin, and neuronal migrations promoted by humoral serotonin; UNC-2 is orthologous to human CACNA1A (OMIM:601011, mutated in familiar hemiplegic migraine or episodic ataxia 2) and to Drosophila CACOPHONY; UNC-2 is expressed primarily in motor neurons, several sensory neurons, and HSN and VC neurons controlling egg-laying. T02D1.1 T02D1.1 Member of the reverse transcriptase protein family, which are RNA-dependent DNA polymerases, has very strong similarity to uncharacterized C. elegans F43G9.7 Reverse transcriptase (RNA-dependent DNA polymerase) T02D1.3 T02D1.3 Protein containing a DUF215 domain of unknown function, has high similarity to uncharacterized C. elegans Y45F10B.6 T02D1.4 T02D1.4 Protein with similarity to G protein-coupled receptors of C. elegans T02D1.5 T02D1.5 Protein with high similarity to ATP-binding cassette subfamily D (ALD) member 2 (mouse Abcd2), which is a peroxisomal membrane protein half-transporter involved in very long chain fatty acid beta-oxidation, member of the ABC transporter family ABC transporters; The pmp-4 gene encodes a homolog of human ALD, which when mutated leads to X-linked adrenoleukodystrophy (OMIM:300100). T02D1.6 T02D1.6 Member of the rhodopsin family of G-protein coupled receptors (GPCR), has a region of low similarity to galanin receptor 1 (mouse Galr1), which inhibits adenylyl cyclase and may mediate digestive, endocrine, and central nervous system functions 7 transmembrane receptor (rhodopsin family) T02D1.7 T02D1.7 Protein with moderate similarity to C. elegans T02D1.6 gene product T02E1.1 spe-12;T02E1.1 Protein required for spermatogenesis spe-12 T02E1.2 T02E1.2 Protein of unknown function T02E1.3 T02E1.3 Protein containing four CCCH-type zinc finger domains, which bind DNA or RNA TS11 protein like T02E1.4 T02E1.4 Protein with moderate similarity to C. elegans T11F9.11 gene product dehydrogenase T02E1.5 T02E1.5 Member of the short-chain dehydrogenase-reductase family, which are NAD- or NADP-dependent oxidoreductases, has moderate similarity to a region of short-chain dehydrogenase-reductase 1 (human SDR1), which reduces all-trans-retinal to retinol 3-oxoacyl-[acyl-carrier protein] reductase; dhs-3 encodes a member of the short-chain dehydrogenases/reductases family (SDR) predicted to be mitochondrial. T02E1.6 T02E1.6 Protein of unknown function T02E1.7 T02E1.7 Member of the SURF4 (surfeit locus) family, has low similarity to S. cerevisiae Erv29p, which is a component of COPII-coated vesicles and is required for vesicular transport between the ER and Golgi Yeast hypothetical protein YG5Y like T02E9.1 T02E9.1 Member of the rhodopsin family of G-protein coupled receptors (GPCR), has low similarity to kappa opioid receptor 1 (mouse Oprk1), which signals through an inhibitory G-protein to modulate sensory and chemosensory perception G-protein coupled receptor T02E9.2 T02E9.2 Protein of unknown function containing a Ground-like domain, has weak similarity to C. elegans F28A12.2 T02E9.3 T02E9.3 Member of the rhodopsin family of G-protein coupled receptors (GPCR), has weak similarity to G protein-linked acetylcholine receptor (C. elegans GAR-1), which functions in synaptic transmission G-protein coupled receptor T02E9.5 T02E9.5 Protein of unknown function T02G5.1 T02G5.1 Protein of unknown function T02G5.10 T02G5.10 Putative ortholog of C. elegans Y73B6BL.15 gene product T02G5.11 T02G5.11 Protein of unknown function, has strong similarity to a region of C. elegans NOS-2, which functions in development of the germ lineage T02G5.12 T02G5.12 Protein with low similarity to solute carrier family 16 member 4 (human SLC16A4), which is a proton-dependent lactate transport protein that is associated with mitochondrial myopathies upon overexpression T02G5.13 T02G5.13 Protein of unknown function T02G5.14 T02G5.14 Protein of unknown function T02G5.2 T02G5.2 Protein of unknown function T02G5.3 T02G5.3 Protein of unknown function T02G5.4 T02G5.4 Protein containing thiolase N-terminal and C-terminal domains, has moderate similarity to acetyl-CoA acetyltransferase (acetoacetyl-CoA thiolase, S. cerevisiae Erg10p), which catalyzes the first step in mevalonate-sterol pathway acetly-CoA thiolase T02G5.5 T02G5.5 Member of the Tc3 Transposase protein family transposase T02G5.6 T02G5.6 Member of the MutS family, which are DNA mismatch repair proteins, has very strong similarity to a region of C. elegans HIM-14, which is required for meiotic recombination This gene encodes a protein predicted by Eisenberg and coworkers, with 52% accuracy, to be mitochondrial. T02G5.7 T02G5.7 Protein with high similarity to acetoacetyl-CoA thiolase I (C. tropicalis T1p), which is involved in the mevalonate pathway of ergosterol biosynthesis and peroxisomal beta-oxidation of fatty acids, contains thiolase N-terminal and C-terminal domains acetoacetyl CoA thiolase; The T02G5.7 gene encodes a homolog of the human gene ACAT1, which when mutated leads to alpha-methylacetoaceticaciduria (OMIM:203750). T02G5.8 T02G5.8 Protein with high similarity to acetyl-CoA acetyltransferase (acetoacetyl-CoA thiolase, S. cerevisiae Erg10p), which catalyzes the first step in the mevalonate-sterol pathway, contains two thiolase N-terminal domains and two thiolase C-terminal domains acetoacetyl-C0A thiolase; kat-1 encodes a homolog of the human gene ACAT1, which when mutated leads to alpha-methylacetoaceticaciduria (OMIM:203750). T02G5.9 T02G5.9 Protein with high similarity to lysyl-tRNA synthetase (human KARS), which is packaged into HIV virions, contains two class II asparagine, aspartic acid and lysine tRNA synthetase (D, K and N) domains and two OB-fold nucleic acid binding domains lysyl-tRNA synthetase T02G6.1 T02G6.1 Protein of unknown function T02G6.2 T02G6.2 Protein of unknown function T02G6.3 T02G6.3 Protein of unknown function T02G6.4 T02G6.4 Protein of unknown function T02G6.5 T02G6.5 Protein containing an F-box domain, which serve as a link between a target protein and a ubiquitin-conjugating enzyme This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins; its encoded protein also contains a Pfam-B45 motif of presently unknown function. T02G6.6 T02G6.6 Protein of unknown function, has weak similarity to C. elegans T22G5.3 T02G6.7 T02G6.7 Member of the galectin family, has a region of moderate similarity to a region of galectin (C. elegans LEC-1), which is a galactoside-binding lectin Vertebrate galactoside-binding lectins T02H6.10 T02H6.C;T02H6.10 Protein of unknown function, has weak similarity to C. elegans C47F8.7 T02H6.11 T02H6.A;T02H6.11 Protein of unknown function ubiquinol-cytochrome c reductase complex subunit T02H6.5 T02H6.5 Putative ortholog of C. elegans F21D9.1 gene product T02H6.6 T02H6.6 Protein with moderate similarity to C. elegans W07E6.5 gene product T02H6.8 T02H6.E;T02H6.8 Protein with strong similarity to C. elegans T02H6.3 gene product T02H6.D T02H6.9;T02H6.D Protein of unknown function, has moderate similarity to C. elegans Y54E2A.9 T02H6.F T02H6.7;T02H6.F Protein of unknown function, has high similarity to uncharacterized C. elegans T02H6.4 T02H6.I T02H6.4;T02H6.I Protein of unknown function, putative paralog of C. elegans T02H6.F T02H6.J T02H6.3;T02H6.J Protein of unknown function, has a region of weak similarity to histidine-rich calcium-binding protein (human HRC), which is a luminal sarcoplasmic reticulum protein that may play a role in calcium homeostasis T02H6.K T02H6.2;T02H6.K Protein with similarity to human nuclear matrix protein P84 T03A1.3 T03A1.3 Protein of unknown function T03A1.4 T03A1.4 Protein containing two calponin homology (CH) domains, which bind actin, has low similarity to plectin 1 (mouse Plec1), which is a cytoskeletal linker protein involved in cell adhesion and motility T03D3.1 T03D3.1 Protein containing a UDP-glucoronosyl and UDP-glucosyl transferase domain, has low similarity to phenobarbital-inducible liver UDP-glucuronosyltransferase (rat Udpgtr-2), which glucuronidates testosterone, 4-hydroxybiphenyl, and chloramphenicol UDP-glucuronosyltransferase T03D3.11 T03D3.11 Member of the 7-transmembrane chemoreceptor family of G-protein coupled receptors (GPCR), has weak similarity to C. elegans ODR-10, which is a G protein-coupled receptor involved in odorant response 7TM chemoreceptor, srj family T03D3.12 T03D3.12 Member of the 7-transmembrane chemoreceptor family of G-protein coupled receptors (GPCR), has weak similarity to C. elegans ODR-10, which is a G protein-coupled receptor involved in odorant response 7TM chemoreceptor, srj family T03D3.14 T03D3.14 Member of the 7-transmembrane chemoreceptor family of G-protein coupled receptors (GPCR), has weak similarity to C. elegans ODR-10, which is a G protein-coupled receptor involved in odorant response 7TM chemoreceptor, srj family T03D3.2 T03D3.2 Member of the 7-transmembrane chemoreceptor family of G-protein coupled receptors (GPCR), has high similarity to uncharacterized C. elegans T03D3.14 7TM chemoreceptor, srj family T03D3.3 T03D3.3 Protein of unknown function, has low similarity to uncharacterized C. elegans C41G6.3 7TM chemoreceptor, srw family T03D3.4 T03D3.4 Protein of unknown function, has high similarity to uncharacterized C. elegans C31B8.11 7TM chemoreceptor, srh family T03D3.5 T03D3.5 Protein of unknown function, has moderate similarity to C. elegans Y49C4A_71.A T03D3.6 T03D3.6 Member of the 7-transmembrane chemoreceptor family of G-protein coupled receptors (GPCR), has high similarity to uncharacterized C. elegans T03D3.11 7TM chemoreceptor, srj family T03D8.1 T03D8.1 Protein containing a phosphotyrosine interaction domain (PID), has strong similarity to D. melanogaster NUMB, a zinc finger and PID domain-containing protein involved in neuronal and muscle cell fate specification Phosphotyrosine interaction domain (PTB/PID). T03D8.2 T03D8.2 Putative mitochondrial ribosomal protein S12; has strong similarity to D. melanogaster TKO (technical knockout) mitochondrial ribosomal protein S12 Ribosomal protein S12 T03D8.3 T03D8.3 Protein of unknown function, has low similarity to a region of secretory granule neuroendocrine protein 1 (rat Sgne1), which is a putative GTP-binding protein that functions as a molecular chaperone and activates proprotein convertase 2 (rat Pcsk2) neuroendocrine protein 7B2 T03D8.4 T03D8.4 Protein of unknown function containing a Ground-like domain, has weak similarity to C. elegans K10C2.5 T03D8.5 gcy-22;T03D8.5 Protein containing a protein kinase domain, an adenylate and guanylate cyclase catalytic domain and three receptor family ligand binding domains, has low similarity to natriuretic peptide receptor A (mouse Npr1), which is associated with hypertension Natriuretic peptides receptors, guanylate cyclase; gcy-22 is predicted to encode a guanylate cyclase. T03D8.6 T03D8.6 Member of the gamma-glutamyltranspeptidase family, has moderate similarity to gamma-glutamyl transferase (gamma glutamyl transpeptidase, mouse Ggtp), which transfers gamma-glutamyl from glutathione to amino acid acceptor and regulates cysteine homeostasis Gamma-glutamyltranspeptidase T03D8.7 T03D8.7 Protein of unknown function, has weak similarity to C. elegans R02F11.1 T03E6.1 T03E6.1 Member of the 7-transmembrane chemoreceptor family of G-protein coupled receptors (GPCR), has very strong similarity to uncharacterized C. elegans T03E6.4 T03E6.2 T03E6.2 Member of the 7-transmembrane chemoreceptor family of G-protein coupled receptors (GPCR), has low similarity to uncharacterized C. elegans T22H6.3 T03E6.3 T03E6.3 Member of the nuclear hormone receptor/Zinc finger protein family zinc finger protein T03E6.4 T03E6.4 Member of the 7-transmembrane chemoreceptor family of G-protein coupled receptors (GPCR), has low similarity to C. elegans ODR-10, which is a G protein-coupled receptor involved in odorant response T03E6.5 T03E6.5 Member of the 7-transmembrane chemoreceptor family of G-protein coupled receptors (GPCR), has moderate similarity to uncharacterized C. elegans W02H5.6 T03E6.6 T03E6.6 Protein of unknown function, has high similarity to uncharacterized C. elegans ZK1037.7, which is predicted to be a G protein-coupled receptor T03E6.7 cpl-1;T03E6.7 Member of the cathepsin L-like cysteine protease protein family cathepsin-like protease; cpl-1 encodes a member of the cathepsin L-like cysteine protease family required for embryonic viability and normal growth; expressed in eggshells and throughout early embryos, accumulates in intestinal cells during late embryogenesis, and expressed in the cuticle, gonad, and pharynx later in development. T03E6.8 T03E6.8 Protein of unknown function, has weak similarity to C. elegans F07C3.10 T03F1.1 T03F1.1 Member of the UBA-THIF-type NAD-FAD binding fold family, has a region of low similarity to a region of S. pombe Uba2p, which is required for activation of ubiquitin-like S. pombe Ubl2p prior to conjugation to other enzymes T03F1.10 T03F1.10 Member of the C-type lectin family, has similarity to human C-type mannose receptor MRC1 and D. melanogaster selectin FW (furrowed) T03F1.11 T03F1.11 Protein containing two EF hand domains, which are found in signaling, buffering or transport proteins T03F1.12 T03F1.12 Protein of unknown function T03F1.2 T03F1.2 Protein with moderate similarity to S. cerevisiae Coq4p, which is involved in coenzyme Q (ubiquinone) biosynthesis T03F1.3 T03F1.3 Protein with high similarity to phosphoglycerate kinase 1 (human PGK1), which catalyzes conversion of 1,3-diphosphoglycerate to 3-phosphoglycerate in glycolysis forming one molecule of ATP, member of the phosphoglycerate kinase family phosphoglycerate kinase; T03F1.3 is orthologous to the human gene PHOSPHOGLYCERETE KINASE 1 (PGK1; OMIM:311800), which when mutated leads to hemolytic anemia and neurologic disturbances. T03F1.4 T03F1.4 Member of the reverse trancriptase family, which are RNA-dependent DNA polymerases, contains a retroviral integrase core domain and a zinc knuckle domain, has strong similarity to uncharacterized C. elegans K02A2.6 T03F1.5 T03F1.5 Protein with very strong similarity to C. elegans W09C3.6, which is involved in spermatogenesis, member of the serine or threonine protein phosphatase family serine/threonine protein phosphatase PP1 T03F1.6 T03F1.6 Protein of unknown function T03F1.7 T03F1.7 Member of the ribosomal RNA adenine dimethylases family, has low similarity to a region of dimethyladenosine transferase, (rRNA (adenine-N6,N6-)-dimethyltransferase, S. cerevisiae Dim1p), which is responsible for 18S rRNA 3'-terminal loop dimethylation T03F1.8 T03F1.8 Protein with high similarity to guanylate kinase (S. cerevisiae Guk1p), which carries out conversion of ATP and has a role in endoplasmic reticulum glycopeptide export, contains a guanylate kinase domain, which catalyze phosphorylation of GMP into GDP guanylate kinase; This gene encodes a protein predicted by Eisenberg and coworkers, with 68% accuracy, to be mitochondrial. T03F1.9 hcp-4;T03F1.9 Protein with weak similarity to H. sapiens ROCK1, Rho-associated, coiled-coil containing protein kinase 1 The hcp-4 gene encodes a centromere protein (CENP)-C homolog, holocentric protein (HCP)-4. T03F6.1 T03F6.1 Protein with high similarity to quinoid dihydropteridine reductase (rat Qdpr), which catalyzes the NADH-dependent reduction of dihydrobiopterin Alcohol/other dehydrogenases, short chain type; The T03F6.1 gene encodes an ortholog of the human gene QUINOID DIHYDROPTERIDINE REDUCTASE (QDPR; DHPR), which when mutated leads to phenylketonuria II (OMIM:261630). T03F6.2 T03F6.2 Protein containing a C2H2 type zinc finger domain and a DnaJ domain, has weak similarity to a region of zuotin related factor 1 (mouse Zrf2), which exhibits both sequence-specific DNA binding and Z-DNA binding DnaJ, prokaryotic heat shock protein, Zinc finger, C2H2 type; This gene encodes a protein containing a DnaJ ('J') domain. T03F6.3 T03F6.3 Protein with high similarity to glucosamine-6-phosphate deaminase (oscillin, human GNPI), which catalyzes the conversion of glucosamine-6-phosphate to fructose-6-phosphate in glucosamine catabolism, member of the glucosamine-6-phosphate isomerase family Glucosamine-6-phosphate isomerase T03F6.4 T03F6.4 Protein of unknown function T03F6.5 lis-1;T03F6.5 Member of the WD repeat protein family, has strong similarity to human LIS1 WD domain, G-beta repeats (4 domains); lis-1 encodes an ortholog of human LIS1, which when mutated leads to lissencephaly (OMIM:247200); it also encodes an ortholog of the Aspergillus nidulans nudF, which mediates nuclear migration along Aspergillus hyphae. T03F6.6 T03F6.6 Protein with strong similarity to C. elegans F56B3.6 gene product T03F7.1 T03F7.1 Protein with high similarity solute carrier family 6 member 1 (human SLC6A1), which is a high affinity sodium and chloride-dependent GABA transporter that plays a role in neurotransmission, member of the sodium:neurotransmitter symporter family Na(+)/Cl(-)-dependent GABA transporter T03F7.2 T03F7.2 Member of the 7-transmembrane chemoreceptor family of G-protein coupled receptors (GPCR), has moderate similarity to uncharacterized C. elegans T03F7.4 T03F7.3 T03F7.3 Member of the 7-transmembrane chemoreceptor family of G-protein coupled receptors (GPCR), has low similarity to uncharacterized C. elegans F58E10.6 T03F7.4 T03F7.4 Member of the 7-transmembrane chemoreceptor family of G-protein coupled receptors (GPCR), has moderate similarity to uncharacterized C. elegans T03F7.2 T03F7.5 T03F7.5 Protein of unknown function, has weak similarity to C. elegans ZC190.2 T03F7.6 T03F7.6 Protein with strong similarity to C. elegans C03E10.1 gene product T03F7.7 T03F7.7 Protein containing a CRAL-TRIO domain, has weak similarity to uncharacterized C. elegans C34C12.6 Candida SEC14 cytosolic factor like T03G11.1 T03G11.1 Protein of unknown function The protein product of this gene is predicted to contain a glutamine/asparagine (Q/N)-rich ('prion') domain, by the algorithm of Michelitsch and Weissman (as of the WS77 release of WormBase, i.e., in wormpep77). T03G11.2 T03G11.2 Protein containing a DUF215 domain of unknown function 7TM chemoreceptor, sru family T03G11.3 T03G11.3 Protein containing a C2H2 type zinc finger domain, which bind nucleic acids T03G11.4 T03G11.4 Member of the glycosyl hydrolase 47 family of alpha-mannosidases, which hydrolyze terminal mannose residues, has moderate similarity to alpha1,2-mannosidase IB (Golgi alpha mannosidase IB, mouse Man1b), which functions in N-glycan maturation man(9)-alpha-mannosidase T03G11.5 T03G11.5 Protein of unknown function exopolygalacturonase T03G11.6 T03G11.6 Protein of unknown function, has moderate similarity to uncharacterized human DREV1 T03G11.8 zig-6;T03G11.8 Protein containing two immunoglobulin (Ig) domains, which may be involved in protein-protein and protein-ligand interactions human leukocyte surface protein (weak); zig-6 encodes a predicted membrane-associated protein containing two C2-type immunoglobulin domains and a GPI (glycosylated phosphatidylinositol) anchor site, but no transmembrane domain; ZIG-6 is predicted to function in cell adhesion and/or signaling, and as loss of zig-6 activity via RNA-mediated interference results in a Clear phenotype, zig-6 appears also to be required for maintenance of body fluid homeostasis; ZIG-6 is expressed in anterior and posterior body wall muscles. T03G6.1 T03G6.1 Protein of unknown function T03G6.2 nhr-40;T03G6.2 Protein with moderate similarity to C. elegans R09G11.2 steroid/thyroid/retinoic nuclear hormone receptor family T03G6.3 T03G6.3 Protein with similarity to human phosphodiesterase I/nucleotide pyrophosphatases (autoautotaxins, tumor motility-stimulating proteins), has weak similarity to S. cerevisiae Ycr026p plasma cell membrane protein and phosphodiesterase I (weak) T04A11.1 T04A11.1 Member of an uncharacterized protein family T04A11.10 T04A11.10 Protein containing a DUF215 domain of unknown function, has high similarity to uncharacterized C. elegans Y45F10B.4 7TM receptor T04A11.2 T04A11.2 Member of an uncharacterized protein family T04A11.3 T04A11.3 Protein containing four fibronectin type III domains, three DB module domains, and one immunoglobulin (Ig) domain, has very strong similarity to uncharacterized C. elegans C25G4.10 fibronectin T04A11.4 T04A11.4 Member of an uncharacterized protein family T04A11.5 T04A11.5 Member of an uncharacterized protein family T04A11.6 T04A11.6 Protein with strong similarity over the middle region to human BLM (Bloom syndrome) and RecQ proteins and other DNA helicases of the DEAD/DEAH box family; has similarity over the N-terminal region to C. elegans G protein-coupled receptors of the SRG subfamily helicase; him-6 encodes a RecQ-like ATP-dependent DNA helicase orthologous to human BLM (OMIM:604610, mutated in Bloom syndrome); HIM-6 is required for normal levels of recombination during meiosis and as such, loss of HIM-6 function results in an increased frequency of genotypically XO males and inviable aneuoploid embryos as a result of higher levels of chromosome nondisjunction; HIM-6 interacts both genetically and in vitro with TOP-3, DNA topoisomerase IIIalpha, with which it functions to regulate genomic stability during germ-line mitosis; HIM-6 is expressed primarily in the germ line. T04A11.7 T04A11.7 Protein containing a DUF215 domain of unknown function, has high similarity to uncharacterized C. elegans T04A11.9 7TM receptor T04A11.8 T04A11.8 Protein containing a DUF215 domain of unknown function, has high similarity to uncharacterized C. elegans Y45F10B.4 7TM receptor T04A11.9 T04A11.9 Protein containing a DUF215 domain of unknown function, has high similarity to uncharacterized C. elegans T04A11.7 7TM receptor T04A6.1 T04A6.1 Protein of unknown function T04A6.2 T04A6.2 Protein of unknown function T04A6.3 T04A6.3 Protein of unknown function, has similarity over the middle region to members of an unnamed protein family including C. elegans Y59E9_116.A T04A8.1 srg-10;T04A8.1 G protein-coupled receptor, probably involved in chemosensation by sensory amphid neurons, no homolog found in human or D. melanogaster 7tm receptor T04A8.10 T04A8.10 Protein of unknown function non-histone chromosomal protein HMG-1 T04A8.11 T04A8.11 Protein of unknown function 50S ribosomal protein L16 T04A8.12 T04A8.12 Protein of unknown function, has moderate similarity to uncharacterized FGF receptor activating protein 1 (rat Frag1) Yeast 107.9KD PGK1-MAK32 intergenic hypothetical protein T04A8.13 T04A8.13 Protein containing an F-box domain, which serve as a link between a target protein and a ubiquitin-conjugating enzyme neurofilament triplet M protein T04A8.14 emb-5;T04A8.14 Putative effector of LIN-12, has strong similarity to S. cerevisiae Spt6p S1 RNA binding domain T04A8.15 T04A8.15 Protein of unknown function glucose-6-phosphate 1-dehydrogenase T04A8.16 T04A8.16 Putative calpain-like thiol protease Calpain thiol protease; clp-2 encodes a large calpain subunit that contains two predicted MIT (microtubule interacting and trafficking) domains and is homologous to the mammalian Calpain 7 proteins and the atypical, nuclear-localized Aspergillus calpain, PalB; by homology, CLP-2 is predicted to function as a calcium-dependent, cysteine protease that is involved in intracellular proteolysis and peptidolysis; however, as loss of clp-2 activity via RNA-mediated interference (RNAi) does not result in any obvious abnormalities, the precise role of CLP-2 in C. elegans development and/or behavior is not yet known. T04A8.2 srg-11;T04A8.2 G protein-coupled receptor, probably involved in chemosensation by sensory amphid neurons, no homolog found in human or D. melanogaster 7tm receptor T04A8.3 T04A8.3 Member of the C-type lectin family C-type lectin T04A8.4 T04A8.4 Protein with strong similarity to C. elegans F36F2.1 gene product T04A8.5 T04A8.5 Putative glutamine phosphoribosyl pyrophosphate (PRPP) amidotransferase, predicted to catalyze the first step in de novo purine biosynthesis Amidophosphoribosyltransferase T04A8.6 T04A8.6 Protein containing an RNA recognition motif (RRM, RBD, or RNP), has low similarity to nucleolar protein interacting with the FHA domain of Ki-67 antigen (nucleolar phosphoprotein 34, human NIFK), which may be involved in mitosis ribonuleoprotein T04A8.7 T04A8.7 Protein with high similarity to glycogen branching enzyme (human GBE1), which is a glycosyl-(4->6)-transferase involved in carbohydrate metabolism, contains an isoamylase N-terminal domain and an alpha amylase N-terminal catalytic domain 1,4-Alpha-glucan branching enzyme; T04A8.7 is orthologous to human GLUCOSIDASE, ACID BETA (GBA; OMIM:606463), which when mutated leads to Gaucher disease. T04A8.8 T04A8.8 Protein of unknown function T04A8.9 T04A8.9 Protein containing a DnaJ domain, which are part of a chaperone (protein folding) system that mediates interaction with heat shock proteins, has a region of moderate similarity to a region of dnaJ homolog subfamily A member 3 (Hsp40, human DNAJA3) DNAJ; This gene encodes a protein containing a DnaJ ('J') domain. T04B2.1 T04B2.1 Member of the short-chain dehydrogenase-reductase family, which are NAD- or NADP-dependent oxidoreductases, has high similarity to uncharacterized C. elegans K08F4.9 T04B2.2 T04B2.2 Protein containing a protein kinase domain and a Src homology 2 (SH2) domain, which are regulatory modules of intracellular signaling, has moderate similarity to fer (fps/fes related) tyrosine kinase (mouse Fert2) Src homology domain 2, tyrosine-protein kinase (FES/FPS subfamily); frk-1 encodes a protein homologous to human proto-oncogene tyrosine kinase FER that affects viability and embryonic epidermal enclosure; expressed in most epithelial tissue types, including the epidermis, pharynx, intestine, and muscle. T04B2.3 T04B2.3 Protein of unknown function T04B2.4 T04B2.4 Protein with weak similarity to members of the SRG subfamily of G protein-coupled receptors G-protein coupled receptor, srv family T04B2.5 T04B2.5 Member of the palatin family, which are storage proteins that may also catalyze the cleavage of fatty acids from membrane lipids, has low similarity to a region of cytosolic group VI phospholipase A2 (mouse Pla2g6), which stimulates arachidonate release T04B2.6 T04B2.6 Member of the short-chain dehydrogenase-reductase family, which are NAD- or NADP-dependent oxidoreductases, has low similarity to a region of 17 beta-hydroxysteroid dehydrogenase type 2 (mouse Hsd17b2) dehydrogenase T04B8.1 T04B8.1 Putative ortholog of C. elegans F46F5.1 gene product T04B8.2 T04B8.2 Protein containing an F-box domain, which serve as a link between a target protein and a ubiquitin-conjugating enzyme, has high similarity to uncharacterized C. elegans T27A1.2 This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins; its encoded protein also contains a Pfam-B45 motif of presently unknown function. T04B8.3 T04B8.3 Protein of unknown function, has strong similarity to C. elegans ZK938.2 T04B8.4 T04B8.4 Protein with strong similarity to C. elegans T27D12.3 gene product T04B8.5 T04B8.5 Putative sodium-potassium-chloride cotransport protein, putative ortholog of H. sapiens SLC12A2 gene product T04C10.1 mbk-1;T04C10.1 Protein containing four protein kinase domains, has low similarity to S. cerevisiae Yak1p, which is a serine-threonine protein kinase that negatively regulates cell growth serine/threonine kinase (2 domains); mbk-1 encodes a putative dual-specificity kinase (predicted to have both serine/threonine and tyrosine substrates) that is orthologous to Drosophila MINIBRAIN and mammalian DYRK1A/MnbK and that has a glutamine/asparagine-rich domain; MBK-1 is found in most or all nuclei, is dispensable for viability, and perturbs olfaction in AWC when overexpressed. T04C10.2 T04C10.2 Protein containing six ubiquitin interaction motifs and three epsin N-terminal homology (ENTH) domains, has moderate similarity to epsin 1 (human EPSIN), which is a component of a multi-protein complex that plays a role in clathrin-mediated endocytosis Yeast hypothetical protein L8167.6 like T04C10.3 T04C10.3 Protein of unknown function T04C10.4 T04C10.4 Protein containing a bZIP (basic-leucine zipper) transcription factor domain transcription factor ATF4 like T04C12.1 T04C12.1 Protein with strong similarity to C. elegans C24B9.9 gene product T04C12.2 T04C12.2 Member of the 7-transmembrane chemoreceptor family of G-protein coupled receptors (GPCR), has high similarity to uncharacterized C. elegans C45B11.4 T04C12.3 T04C12.3 Protein of unknown function T04C12.4 act-1;T04C12.4 Actin actin; act-3 encodes an invertebrate actin, highly similar to ACT-1, ACT-2, and ACT-4, that functions in body wall muscle. T04C12.5 act-2;T04C12.5 Member of the actin and actin-related protein family actin; act-2 encodes an invertebrate actin that may function specifically in the pharynx. T04C12.6 act-3;T04C12.6 Member of the actin and actin-related protein family actin; An actin that affects body wall and pharyngeal muscle structure and function and motility of animals. T04C4.1 T04C4.1 Protein of unknown function, has weak similarity to C. elegans Y94H6A_124.A T04C9.1 T04C9.1 Protein containing a pleckstrin homology (PH) domain, which mediate protein-protein interactions, a RhoGAP (GTPase activator protein) domain, and a Src homology 3 (SH3) domain, has a region of moderate similarity to oligophrenin 1 (human OPHN1) T04C9.2 T04C9.2 Protein of unknown function T04C9.3 T04C9.3 Protein of unknown function dual bar protein (weak) T04C9.4 T04C9.4 Protein containing three LIM domains, which may mediate protein-protein interactions, has a region of moderate similarity to cysteine- and glycine-rich protein 3 (mouse Csrp3), which is a zinc-finger LIM domain protein required for heart development contains LIM-like binding domain T04C9.6 T04C9.6 Protein containing one FERM domain (Band 4.1 family), which link cytoplasmic proteins to membranes, has low similarity to differentially expressed adenocarcinoma of lung 1 (human EPB41L3), which suppresses cancer cell growth band 4.1-like domain T04D1.2 T04D1.2 Protein containing an F-box domain, which serve as a link between a target protein and a ubiquitin-conjugating enzyme, has low similarity to uncharacterized C. elegans Y39A1A.16 This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins; its encoded protein also contains a Pfam-B45 motif of presently unknown function. T04D1.3 T04D1.3 Protein containing a Src homology 3 (SH3) domain, which bind proline-rich peptides, has moderate similarity to SH3-domain GRB2-like 1 (rat Sh3p8), which binds synaptojanin and dynamin and may be involved in synaptic vesicle recycling unc-57 encodes an ortholog of endophilin A that is required for synaptic vesicle endocytosis; UNC-57 is expressed in all neurons, at synapses and neuromuscular junctions, and (weakly) in the spermetheca; like other endophilins, UNC-57 has a large BAR domain, an N-terminal coiled-coil domain within the BAR domain, and a C-terminal SH3 domain; UNC-57 protein is necessary for proper localization of UNC-26 (synaptojanin) protein, which in turn is needed for endocytosis; unc-57 and unc-26 mutants are morphologically, ultrastructurally, and electrophysiologically similar both to one another and to double mutants, indicating that UNC-57 and UNC-26 act in a single genetic pathway. T04D1.4 T04D1.4 Protein containing a helicase conserved C-terminal domain and an SNF2 related N-terminal domain, has a region of low similarity to mouse Chd1, which is a DNA binding protein implicated in regulation of gene expression and chromatin structure helicase; The protein product of this gene is predicted to contain a glutamine/asparagine (Q/N)-rich ('prion') domain, by the algorithm of Michelitsch and Weissman (as of the WS77 release of WormBase, i.e., in wormpep77). T04D3.1 T04D3.1 Protein of unknown function, has low similarity to uncharacterized C. elegans T04D3.2 T04D3.2 T04D3.2 Protein of unknown function, has strong similarity to C. elegans M01E5.6 T04D3.3 T04D3.3 Protein with high similarity to Ca2+-calmodulin dependent cyclic nucleotide phosphodiesterase (rat Pde1c), which has high affinity for cAMP, member of the 3',5'-cyclic nucleotide phosphodiesterase family 3',5' cyclic phosphodieterase T04D3.4 gcy-35;T04D3.4 Protein containing an adenylate and guanylate cyclase catalytic domain, has moderate similarity to rat Gucy1b2, which is the beta 2 subunit of guanylate cyclase that is involved in GTP to cGMP conversion and binds nitric oxide and nitrovasodilator drugs guanylate cyclase beta subunit T04D3.5 T04D3.5 Protein of unknown function T04D3.8 T04D3.8 Protein of unknown function T04F3.1 T04F3.1 Putative coiled-coil protein, has weak similarity to myosin heavy chains and human centromere proteins CENPE and CENPF 1-aminocyclopropane-1-carboxylate synthase T04F3.2 T04F3.2 Protein containing a thyroglobulin type-1 repeat, which may be involved in the control of proteolytic degradation, has low similarity to uncharacterized human SMOC2 thyroglobulin and EF hand domains T04F3.3 T04F3.3 Member of the protein-tyrosine phosphatase family, has a region of weak similarity to a region of protein tyrosine phosphatase non-receptor type 9 (human PTPN9), which is a non-membrane spanning tyrosine phosphatase that may be associated with autism protein tyrosine phosphatase T04F3.4 T04F3.4 Protein with weak similarity to H. sapiens Hs.159525 (Human cell growth regulator CGR11 mRNA, complete cds) EF hand domains T04F8.1 T04F8.1 Protein of unknown function, has high similarity to uncharacterized mouse Sfxn1 T04F8.2 T04F8.2 Protein of unknown function, has weak similarity to C. elegans C15A7.2 T04F8.3 T04F8.3 Protein of unknown function T04F8.4 T04F8.4 Protein with strong similarity to C. elegans cuticulin CUT-1, putative paralog of C. elegans Y53H1B.B cuticlin T04F8.6 T04F8.6 Protein of unknown function T04F8.7 T04F8.7 Protein of unknown function T04F8.8 T04F8.8 Protein of unknown function T04G9.1 T04G9.1 Protein containing an AT-hook motif, which bind DNA with a preference for A-T rich regions T04G9.2 T04G9.2 Member of the astacin (M12A) family of metalloproteases, has a region of moderate similarity to a region of tolloid-like 1 (human TLL1), which is a metalloprotease that may mediate collagen-elastin crosslinking during extracellular matrix biogenesis zinc metalloprotease T04G9.3 T04G9.3 Protein of unknown function, has low similarity to a region of mannose-binding lectin 1 (rat Lman1), which is a mannose-binding lectin that is localized to the endoplasmic reticulum and Golgi apparatus similar to mammalian lectin VIP36 T04G9.4 T04G9.4 Member of the 4'-phosphopantetheinyl transferase (holo-acyl carrier protein synthase, ACPS) family, has moderate similarity to uncharacterized C. elegans T28H10.1 B. subtilis sfp protein; Anabaena sp. HETI protein T04G9.5 T04G9.5 Protein of unknown function, has moderate similarity to uncharacterized signal sequence receptor beta (translocon-associated protein beta, human SSR2), which is a putative beta subunit of the signal sequence receptor complex C. familiaris signal sequence receptor beta T04G9.6 T04G9.6 Protein of unknown function T04G9.7 T04G9.7 Protein of unknown function T04H1.1 T04H1.1 Protein of unknown function, has high similarity to uncharacterized C. elegans T02B11.6 sodium/phosphate transporter T04H1.10 T04H1.10 Protein of unknown function, has low similarity to uncharacterized C. elegans F20E11.6 7TM chemoreceptor, srw family T04H1.2 T04H1.2 Protein containing an elongation factor Tu GTP binding domain, which contain a P-loop motif, and an elongation factor Tu domain 2, which are involved in binding to charged tRNA, has moderate similarity to GTP binding protein 1 (human GTPBP1) GTP-binding protein T04H1.3 T04H1.3 Member of the transthyretin-like family, has high similarity to uncharacterized C. elegans F09F3.6 Transthyretin-like family T04H1.4 rad-50;RAD50;T04H1.4 Protein with low similarity to RAD50 (S. cerevisiae) homolog (human RAD50), which is a subunit of a double-strand break repair complex that may be involved in sensing of abnormal DNA structures and is associated with gastrointestinal carcinomas DNA repair protein RAD50 like T04H1.5 T04H1.5 Protein containing a G-patch domain, which are found in RNA processing proteins T04H1.6 lrx-1;T04H1.6 Protein containing three low-density lipoprotein (LDL) receptor class A domains, has moderate similarity to a region of low density lipoprotein receptor-related protein 1B (human LRP1B), which acts in endocytosis and is inactivated in some lung cancers low-density lipoprotein receptor; lrx-1 encodes a protein that contains four class A low-density lipoprotein receptor domains. T04H1.7 T04H1.7 Member of the UDP-glucuronosyltransferase protein family UDP-sugartransferase T04H1.8 T04H1.8 Member of the UDP-glucuronosyltransferase protein family UDP-glucuronosyltransferase T04H1.9 T04H1.9 Protein with high similarity to beta tubulin (C. elegans BEN-1), which is involved in drug susceptibility and resistance, member of the tubulin-FtzA family, which are involved in polymer formation tubulin beta-chain T05A1.1 npr-2;T05A1.1 G protein-coupled receptor with similarity to human and D. melanogaster neuropeptide Y receptors G-protein coupled receptor T05A1.2 T05A1.2 Protein with high similarity to C. elegans SQT-3, which is a collagen involved in epithelium morphogenesis and cuticle synthesis, contains two collagen triple helix repeats and one nematode cuticle collagen N-terminal domain collagen T05A1.3 T05A1.3 Protein containing nine leucine rich repeats, has a region of weak similarity to a region of slit homolog 1 (Drosophila) (mouse Slit1), which is a ligand for mouse Robo1 and may be involved in midline neural development and axon guidance Leucine Rich Repeat (2 copies) (6 domains) T05A1.4 T05A1.4 Protein containing a retroviral integrase core domain, which are the central catalytic domains that can act as endonucleases, has high similarity to uncharacterized C. elegans T14G12.5 T05A1.5 T05A1.5 Protein with weak similarity to human renal organic anion transporter ROAT1, member of the major facilitator superfamily This gene encodes a protein predicted by Eisenberg and coworkers, with 52% accuracy, to be mitochondrial. T05A1.7 T05A1.7 Protein of unknown function, has weak similarity to a region of human SLC22A1, which is an organic cation transporter that mediates the elimination of diverse endogenous amines and xenobiotics T05A10.1 T05A10.1 Protein containing seven C2H2 type zinc finger domains, has a region of high similarity to a region of human immunodeficiency virus type I enhancer-binding protein 1 (human HIVEP1), which binds the HIV NF-kappa B motif and other related enhancer elements sma-9 encodes, by alternative splicing, at least two large (~2000-residue) protein with at least three N-terminal involucrin domains, seven C-terminal zinc-finger domains, and a glutamine/asparagine-rich domain; SMA-9 is orthologous to human HIVEP1 (OMIM:194540), HIVEP2 (OMIM:143054), and HIVEP3 (OMIM:606649), and to Drosophila SCHNURRI (FBgn0003396); SMA-9 proteins are required for growth to normally large body size. T05A10.2 T05A10.2 Protein of unknown function, has moderate similarity to C. elegans C09F12.1 clc-4 encodes a claudin homolog that may be required for normal cohesion of apical junctions in epithelia; CLC-4 is worm-specific, with obvious homologs only in C. elegans; claudins are integral membrane proteins with four transmembrane sequences that are found in mammalian tight junctions (TJs), induce TJs when transgenically expressed in cells normally lacking them, and can mediate the specific conductance of of specific ions (e.g., magnesium or calcium) through TJs while blocking the flow of water. T05A10.3 T05A10.3 Member of the transthyretin-like family Transthyretin-like family T05A10.4 T05A10.4 Protein with moderate similarity to C. elegans vap-1 gene product SCP-like extracellular Proteins T05A10.5 T05A10.5 Member of the SCP-like extracellular protein family, has low similarity to testis specific protein 1 (rat Tpx1), which functions as a cell adhesion molecule that mediates interactions between spermatogenic and Sertoli cells testes-specific protein like T05A10.6 T05A10.6 Protein of unknown function T05A12.1 T05A12.1 Putative G protein-coupled receptor, no homolog found in human or D. melanogaster 7TM chemoreceptor, srx family T05A12.2 T05A12.2 Member of the trehalase family, which are O-glycosyl hydrolases, has moderate similarity to trehalase (human TREH), which catalyzes the hydrolysis of the disaccharide alpha, alpha-trehalose and plays a role in carbohydrate digestion and metabolism trehalase precursor; tre-2 encodes one of four putative trehalases in C. elegans of unknown function, as RNAi analysis has not produced an obvious phenotype; expressed throughout development. T05A12.3 T05A12.3 Protein of unknown function, has weak similarity to C. elegans R07G3.3 T05A6.1 cki-1;T05A6.1 G1-phase cyclin-dependent kinase inhibitor; member of the CIP/KIP (p21/p27) family of cyclin-dependent kinase inhibitors cki-1 encodes a homolog of the mammalian cyclin-dependent kinase inhibitor p27/KIP1 that is required for the arrest of cell division in larval blast lineages, dauer larvae and starved L1 larvae; excess CKI-1 expression prematurely stops cell division while cki-1(RNAi) induces extra cell divisions, indicating that CKI-1 quantitatively regulates the amount of mitosis in postembryonic worms. T05A6.2 cki-2;T05A6.2 G1 phase cyclin-dependent kinase inhibitor; member of the CIP/KIP (p21/p27) family of cyclin-dependent kinase inhibitors posterior sex combs protein-like domain; cki-2 encodes a cyclin-dependent kinase (CDK) inhibitor of the CIP/KIP family, orthologous to human CDKN1C (OMIM:600856, which when mutated leads to Beckwith-Wiedemann syndrome) that may play a role in cell cycle progression during embryogenesis; CKI-2 interacts with PCN-1, a proliferating cell nuclear antigen homolog, SMO-1, a SUMO (ubiquitin related) homolog, and the RING domain-containing protein C06A5.9. T05A6.4 T05A6.4 Protein containing a DUF41 domain of unknown function, has high similarity to uncharacterized C. elegans Y37A1B.8 T05A6.5 T05A6.5 Protein of unknown function, has low similarity to uncharacterized C. elegans Y37A1B.9 T05A7.1 T05A7.1 Protein of unknown function, has weak similarity to C. elegans F58G1.4 T05A7.2 T05A7.2 Member of the C-type lectin protein family T05A7.3 T05A7.3 Protein containing a CUB domain, which often occurs extracellularly in developmentally regulated proteins T05A7.4 hmg-11;hmg-I-alpha;T05A7.4 Protein of unknown function nuclear phosphoprotein (weak) T05A7.5 T05A7.5 Protein with similarity to human and C. elegans alpha (1,3) fucosyltransferases galactoside 3(4)-L-fucosyltransferase (weak) T05A7.6 T05A7.6 Protein containing three protein kinase domains, has a region of low similarity to casein kinase 1 epsilon (human CSNK1E), which is a serine/threonine protein kinase with broad substrate specificity that may function in DNA repair casein kinase T05A7.7 T05A7.7 Protein with weak similarity to C. elegans T10E10.4 7TM chemoreceptor, sre family T05A7.8 T05A7.8 Member of the C. elegans Sre G protein-coupled chemoreceptor family, which are putative chemosensory receptors, has low similarity to uncharacterized C. elegans Y39G8B.3 7TM chemoreceptor, sre family T05A7.9 T05A7.9 Protein containing three GLTT repeat region domains small histidine-alanine-rich protein precursor (SHARP) T05A8.1 T05A8.1 Protein with strong similarity to C. elegans Y47G7B.2 gene product T05A8.2 T05A8.2 Protein of unknown function T05A8.3 T05A8.3 Protein of unknown function T05A8.4 T05A8.4 Member of the M13 peptidase family of zinc metalloproteases, has moderate similarity to mel transforming oncogene-like 1 (soluble secreted endopeptidase, mouse Mell1), which is a type II membrane bound metalloprotease that has an alternative secreted form protease; T05A8.4 encodes a neprilysin; neprilysins are thermolysin-like zinc metallopeptidases, found on the outer surface of animal cells, that negatively regulate small signalling peptides (e.g., enkephalin, tachykinin, insulin, and natriuretic peptides) by cleaving them; while T05A8.4 is an ortholog of mammalian neutral endopeptidase (NEP), expressed on the brush-border membranes of kidney; more generally, T05A8.4 falls into a group of proteins that includes the classical neprilysins found in mammals (e.g., PEX [OMIM:307800] and the enkephalin cleaving enzymes). T05A8.5 T05A8.5 Protein containing four WD domains (WD-40 repeat), has a region of low similarity to a region of katanin p80 subunit B1 (human KATNB1), which is the regulatory subunit of katanin, an ATPase that severs and disassembles microtubules into tubulin dimers T05A8.6 T05A8.6 Protein of unknown function T05B11.1 T05B11.1 Protein containing an F-box domain, which serve as a link between a target protein and a ubiquitin-conjugating enzyme This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins. T05B11.2 T05B11.2 Member of an uncharacterized protein family T05B11.3 T05B11.3 Protein with weak similarity to D. melanogaster Clc (Clathrin light chain) T05B11.4 T05B11.4 Protein containing a DUF138 domain of unknown function, has strong similarity to uncharacterized C. elegans F46F5.7 T05B4.1 T05B4.1 Protein containing a neurotransmitter-gated ion-channel ligand binding domain, has weak similarity to 5-hydroxytryptamine 3B (serotonin) receptor subunit (rat Htr3b), which associates with subunit rat Htr3a to form ligand-gated cation channels ionic channel protein T05B4.10 T05B4.10 Protein containing a DUF18 domain of unknown function, has strong similarity to uncharacterized C. elegans T05B4.9 T05B4.11 T05B4.11 Protein containing a DUF18 domain of unknown functionm has high similarity to uncharacterized C. elegans T05B4.8 T05B4.12 T05B4.12 Protein containing a DUF18 domain of unknown function, has strong similarity to uncharacterized C. elegans T05B4.3 T05B4.13 T05B4.13 Protein containing a DUF18 domain of unknown function, has low similarity to uncharacterized C. elegans F49F1.6 T05B4.2 nhr-57;T05B4.2 Member of the nuclear hormone receptor/ Zinc finger protein family zinc finger protein T05B4.3 T05B4.3 Protein containing a DUF18 domain of unknown function, has strong similarity to uncharacterized C. elegans T05B4.12 T05B4.4 T05B4.4 Protein containing a DUF18 domain of unknown function, has high similarity to uncharacterized C. elegans Y46H3D.8 T05B4.5 T05B4.5 Putative ortholog of C. elegans T05B4.7 gene product 7TM chemoreceptor, srw family T05B4.6 T05B4.6 G protein-coupled receptor of unknown function, no homolog found in human or D. melanogaster 7TM chemoreceptor, srw family T05B4.7 T05B4.7 G protein-coupled receptor of unknown function, no homolog found in human or D. melanogaster 7TM chemoreceptor, srw family T05B4.8 T05B4.8 Protein containing a DUF18 domain of unknown function, has strong similarity to uncharacterized C. elegans T05B4.10 T05B4.9 T05B4.9 Protein containing a DUF18 domain of unknown function, has strong similarity to uncharacterized C. elegans T05B4.10 T05B9.1 T05B9.1 Protein of unknown function T05B9.2 T05B9.2 Protein of unknown function T05C1.1 T05C1.1 Protein of unknown function, predicted to contain a glycosylphosphatidylinositol (GPI) lipid anchor T05C1.2 T05C1.2 Protein of unknown function T05C1.3 T05C1.3 Protein of unknown function T05C1.4 T05C1.4 Protein containing three IQ calmodulin-binding domains T05C1.4 encodes, by alternative splicing, two members of the CAMTA family of calmodulin-binding transcriptional activators that are required for embryonic development; CAMTA proteins are conserved in animals and plants but absent from unicellular eukaryotes, and may thus represent a transcriptional activator specific to multicellular organisms; the common organization of CAMTA proteins is to have two N-terminal DNA-binding domains (CG-1 and TIG), followed by two ankyrin repeats, and then two or more calmodulin-binding IQ repeats. T05C1.5 T05C1.5 Protein of unknown function T05C1.6 T05C1.6 Protein containing two ankyrin (Ank) repeats, which may mediate protein-protein interactions, and an IPT or TIG domain, which contain immunoglobulin-like folds, has weak similarity to uncharacterized human KIAA0909 T05C12.1 T05C12.1 Protein containing a protein kinase domain, has low similarity to S. pombe Hhp1p, which is a putative casein kinase I (CKI) that is required for DNA repair serine/threonine kinase T05C12.10 M110;T05C12.10 Protein containing a C-terminal Hint (hedgehog/intein) domain, has similarity to hedgehog proteins and to D. melanogaster VKG, collagen type IV hedgehog-like protein T05C12.2 acr-14;T05C12.2 Protein containing neurotransmitter-gated ion-channel ligand binding and transmembrane domains, has moderate similarity to C. elegans ACR-16, which is a nicotinic acetylcholine receptor alpha-1 subunit neuronal acetylcholine receptor protein; acr-14 encodes a protein that contains neurotransmitter-gated ion-channel ligand-binding and transmembrane domains. T05C12.3 T05C12.3 Putative Delta(2),Delta(4)-dienoyl-CoA reductase 2,4-dienoyl-CoA reductase; This gene encodes a protein predicted by Eisenberg and coworkers, with 68% accuracy, to be mitochondrial. T05C12.4 T05C12.4 Protein of unknown function T05C12.5 T05C12.5 Protein with similarity to t-complex-associated-testis-expressed (tctex-1) light chain dynein of human, mouse, rat, D. melanogaster, and Chlamydomonas reinhardtii tctex-1 T05C12.6 mig-5;T05C12.6 Protein containing three DIX or DAX (dishevelled and axin) domains, which may be involved in the Wnt-mediated signaling pathway, three PDZ, DHR, or GLGF domains, and three domains of unknown function, has low similarity to dishevelled 2 (mouse Dvl2) presynaptic density protein (PSD-95) repeat-like domain; mig-5 encodes one of three C. elegans Dishevelled homologs; as part of both canonical and non-canonical Wnt signaling pathways, mig-5 activity is required maternally and embryonically for cell migration, cell fate specification, and proper spindle orientation in the early embryo; cells affected by mig-5 mutations include the distal tip cells (DTCs), the QL neuroblast descendants (QL.d), the vulval precursor cells, and the P12 ectoblast; in the early embryo, MIG-5 functions downstream of MOM-2/Wnt and MOM-1/Porc, and redundantly with two other Dishevelled homologs, DSH-1 and DSH-2, in a non-canonical Wnt pathway that specifies the endoderm cell fate and regulates mitotic spindle orientation in the EMS and ABar blastomeres; in posteriorly directed QL.d migrations, MIG-5 functions downstream of EGL-20/Wnt and upstream of PRY-1/Axin in a canonical Wnt pathway to positively regulate Wnt signaling and effect MAB-5 expression in QL.d; a mig-5::GFP fusion is reportedly expressed in many cells in the embryo, migrating DTCs, P cells, and the nerve ring. T05C12.7 cct-1;T05C12.7 Member of the chaperonin complex protein family T-complex protein; eukaryotic cytosolic chaperonin; affects viability and fertility, and is expressed in various muscle and neuronal cells: near the pharynx, near the anal sphincter, in the ventral nerve cord and the nerve ring; occasionally the expression is visible in hypodermal cells and in some vulval cells. T05C12.8 T05C12.8 Protein of unknown function T05C12.9 T05C12.9 Protein of unknown function T05C3.1 nhr-47;T05C3.1 Protein containing a nuclear hormone receptor C4-type zinc finger domain, has high similarity to a region of nuclear receptor subfamily 4 (group A, member 2) (rat Nr4a2), which is a transcriptional coactivator zinc-finger protein T05C3.2 T05C3.2 Protein with strong similarity to C. elegans F09G2.8, has two copies of a motif characteristic of phospholipase D related proteins The T05C3.2 gene encodes a protein that may be involved in apoptosis. T05C3.3 T05C3.3 Protein with weak similarity to C. elegans unc-15 (Paramyosin, major component of muscle filaments, structural equivalent of the rod region of myosin heavy chains) T05C3.4 T05C3.4 Protein with similarity to G protein-coupled receptors of the SRG subfamily, no homolog found in human or D. melanogaster T05C3.5 T05C3.5 Protein with high similarity to dnaJ homolog subfamily A member 2 (Hsp40, human DNAJA2), which is a cochaperone for hsc70 (HSPA8) involved in protein import into the mitochondrial, contains DnaJ, cysteine-rich DnaJ central, and DnaJ C-terminal domains DNAJ-like protein; This gene encodes a protein containing a DnaJ ('J') domain. T05C3.6 T05C3.6 Putative ortholog of C. elegans F09G2.8 gene product The T05C3.6 gene encodes a paralog of T05C3.2, a protein with NACHT and WD domains that may be involved in apoptosis. T05D4.1 T05D4.1 Fructose-1,6-bisphosphate aldolase Fructose-bisphosphate aldolase class-I; T05D4.1 is orthologous to the human gene ALDOLASE A, FRUCTOSE-BISPHOSPHATE (ALDOA; OMIM:103850), which when mutated leads to aldolase A deficiency. T05D4.2 T05D4.2 Protein of unknown function, has weak similarity to C. elegans F22G12.3 T05D4.3 T05D4.3 Protein of unknown function T05D4.4 T05D4.4 Protein of unknown function, has moderate similarity to C. elegans K02F3.7 T05D4.5 T05D4.5 Protein containing a major sperm protein (MSP) domain, which are involved in sperm motility T05E11.1 rps-5;T05E11.1 Protein with high similarity to ribosomal protein Rps5p (S. cerevisiae Rps5p), which is a ribosomal structural protein, contains a ribosomal S7p or S5e domain, which are present in the small ribosomal subunit 40S ribosomal protein S5; rps-5 encodes a small ribosomal subunit S5 protein. T05E11.2 T05E11.2 Protein of unknown function T05E11.2 encodes a claudin homolog that may be required for normal cohesion of apical junctions in epithelia; T05E11.2 is worm-specific, with a with highly divergent sequence lacking obvious homologs; T05E11.2 has no obvious function in mass RNAi assays; claudins are integral membrane proteins with four transmembrane sequences that are found in mammalian tight junctions (TJs), induce TJs when transgenically expressed in cells normally lacking them, and can mediate the specific conductance of of specific ions (e.g., magnesium or calcium) through TJs while blocking the flow of water. T05E11.3 T05E11.3 Protein with high similarity to tumor rejection antigen 1 (human TRA1), which is a putative molecular chaperone that may play roles in protein folding, member of the heat shock Hsp90 protein family, contains a histidine kinase-like ATPase domain endoplasmin precursor (GRP94) T05E11.4 spo-11;T05E11.4 Topoisomerase-like protein that generates double strand breaks to initiate recombination during meiosis; homolog of yeast Spo11p spo-11 encodes an ortholog of Spo11p in S. cerevisiae that is required for meiotic DNA recombination, and (in conjunction with CHK-2 and MRE-11) for the localization of RAD-51 to foci in late zygotene/early pachytene nuclei; like its yeast ortholog, SPO-11 is related to a subunit of archaebacterial topoisomerase VI, and probably causes double-stranded DNA breaks through a topoisomerase-like transesterase mechanism; however, unlike Spo11p, SPO-11 is dispensable for homologous synapsis and formation of the synaptonemal complex; SPO-11 is active even in syp-1 mutants where its double-stranded breaks cannot be correctly processed; spo-11 is transcribed in the germline. T05E11.5 T05E11.5 Protein with low similarity to histocompatibility 13 (mouse H13), which is a minor antigen and source of nonapeptide presented by the Db MHC class I molecule that induces cellular immune responses resulting in graft rejection and graft-versus-host disease Yeast YKK0 like T05E11.6 T05E11.6 Putative glycosylphosphatidylinositol (GPI) transamidase haemoglobinase like T05E11.7 T05E11.7 Protein containing a DUF236 domain of unknown function, has high similarity to uncharacterized C. elegans F47B3.5 T05E11.8 T05E11.8 Protein containing a DUF148 domain of unknown function, has high similarity to uncharacterized C. elegans T23G4.5 T05E12.1 T05E12.1 Member of the 7-transmembrane chemoreceptor family of G-protein coupled receptors (GPCR), has low similarity to C. elegans ODR-10, which is involved in odorant response T05E12.2 T05E12.2 Protein containing two DUF40 domains of unknown function, which contain four conserved cysteines, has high similarity to uncharacterized C. elegans C45H4.16 7TM receptor, srbc family T05E12.3 T05E12.3 Protein with moderate similarity to C. elegans ZC239.15 T05E12.4 T05E12.4 Protein with strong similarity to C. elegans F49A5.8 gene product 7TM chemoreceptor, srw family T05E12.5 T05E12.5 Protein of unknown function, has moderate similarity to C. elegans C29F3.7 T05E12.6 T05E12.6 Protein containing a DUF141 domain of unknown function, has weak similarity to uncharacterized C. elegans K08D8.5 T05E12.7 T05E12.7 Member of the 7-transmembrane chemoreceptor family of G-protein coupled receptors (GPCR), has high similarity to uncharacterized C. elegans T26H5.3 T05E7.1 T05E7.1 Putative acyl-CoA thioesterase T05E7.2 T05E7.2 Protein containing a nematode cuticle collagen N-terminal domain, has a region of moderate similarity to a region of C. elegans BLI-1, which is a putative collagen involved in embryogenesis and morphogenesis and chemotaxis T05E7.3 T05E7.3 Protein of unknown function, has strong similarity to ubiquitously-expressed human Hs.8294 gene product T05E7.4 T05E7.4 Protein of unknown function T05E7.5 T05E7.5 Putative coiled-coil protein, has weak similarity to S. cerevisiae Myo1p, a myosin heavy chain polypeptide T05E8.1 T05E8.1 Protein of unknown function, has strong similarity to a region of C. elegans FER-1, which is expressed in the testis and is required for functional sperm T05E8.2 T05E8.2 Putative haspin-like protein kinase T05E8.3 T05E8.3 Protein containing a helicase conserved C-terminal domain, has low similarity to S. cerevisiae Prp43p, which is a pre-mRNA splicing factor helicase; The T05E8.3 gene encodes a divergent DEAH helicase that is (apparently) unique to Caenorhabditis; it has no well-characterized orthologs in the complete Drosophila or S. cerevisiae genomes, and no obvious orthologs in the draft human genome sequence either. T05F1.1 T05F1.1 Protein with weak similarity to S. cerevisiae YMR317W T05F1.10 T05F1.10 Member of the short-chain dehydrogenase-reductase family, which are NAD- or NADP-dependent oxidoreductases, has low similarity to short-chain dehydrogenase-reductase 1 (human SDR1), which catalyzes the reduction of all-trans-retinal to retinol Alcohol/other dehydrogenases, short chain type; dhs-4 encodes a short-chain dehydrogenase predicted to be mitochondrial. T05F1.11 T05F1.11 Putative ortholog of C. elegans F17B5.1 gene product This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins. T05F1.12 T05F1.12 Member of the reverse transcriptase protein family, which are RNA-dependent DNA polymerases, has high similarity to uncharacterized C. elegans C12D12.6 reverse transcriptase T05F1.2 T05F1.2 Protein of unknown function T05F1.3 rps-19;rpS19;T05F1.3 Protein with high similarity to ribosomal protein S19 (S. cerevisiae Rps19ap), which is a ribosomal structural protein, member of the ribosomal S19e family, which are part of the small ribosomal subunit Ribosomal protein S19e; rps-19 encodes a small ribosomal subunit S19 protein, orthologous to human RPS19 (OMIM:603474, mutated in Diamond-Blackfan anemia). T05F1.4 T05F1.4 Protein of unknown function T05F1.5 T05F1.5 Member of an uncharacterized protein family T05F1.6 hsr-1;T05F1.6 Protein containing two BRCA1 (breast cancer type 1) C terminus (BRCT) domains, has weak similarity to a region of transformation-related protein p53-binding protein 1 (mouse Trp53bp1), which is a transcription factor inhibitor BRCA1 C Terminus (BRCT) domain; hsr-9 encodes a protein containing a BRCT (BRCA 1 C terminus) domain that is found in proteins that regulate the cell cycle checkpoint in response to DNA damage; HSR-9 activity is required for a normal response to DNA damage caused by gamma-irradiation; loss of HSR-9 function via RNA-mediated interference after gamma-irradiation results in defects in mitotic cell cycle arrest, reduction of apoptosis of pachytene nuclei, and radiation sensitivity of progeny; the expression pattern and subcellular localization of HSR-9 are not yet known. T05F1.7 T05F1.7 Putative coiled-coil protein, has similarity to S. cerevisiae Zip1p, a structural protein of the synaptonemal complex T05F1.8 T05F1.8 Member of the mitochondrial carrier protein family of membrane transporters, has moderate similarity to mitochondrial import receptor (S. cerevisiae Mir1p), which is a phosphate transporter mitochondrial phosphate carrier protein T05F1.9 T05F1.9 Protein of unknown function, has weak similarity to C. elegans F59B2.9 T05G11.1 T05G11.1 Protein containing six C2H2 type zinc finger domains, has a region of low similarity to a region of C. elegans HAM-2, which is a putative transcription factor required for hermaphrodite-specific neuron migration and a downstream target of C. elegans EGL-5 Zinc finger, C2H2 (2 domains) T05G11.2 T05G11.2 Protein containing a DUF40 domain of unknown function, which contain four conserved cysteines, has high similarity to uncharacterized C. elegans M01B2.3 7TM receptor, srbc family T05G11.3 T05G11.3 G protein-coupled receptor of unknown function, no homolog found in human or D. melanogaster 7TM chemoreceptor, srw family T05G11.4 T05G11.4 G protein-coupled receptor of unknown function, has weak similarity to human coagulation factor II (thrombin) receptor-like protein 7TM chemoreceptor, srw family T05G11.6 T05G11.6 G protein-coupled receptor of unknown function, has weak similarity to D. melanogaster neuropeptide Y receptor NepYr T05G11.7 T05G11.7 G protein-coupled receptor of unknown function, no homolog found in human or D. melanogaster 7TM chemoreceptor, srw family T05G5.1 T05G5.1 Protein with weak similarity to D. melanogaster Tm2 tropomyosin 2 Caldesmon-like repeats T05G5.10 T05G5.10 Protein with high similarity to translation initiation factor eIF5A (S. cerevisiae Hyp2p), contains a eukaryotic initiation factor 5A hypusine DNA-binding OB fold domain and a eukaryotic initiation factor 5A hypusine SH3-like barrel domain Initiation factor 5A; iff-1 encodes an eIF-5A homolog that affects fertility and is required for germ cell proliferation and for some P granule components to localize properly; expression is germline specific and mRNA is expressed in the distal region of gonads where germ cells actively proliferate. T05G5.11 dao-6;CePqM96;T05G5.11 Paraquat-inducible protein T05G5.2 T05G5.2 Member of the helix-loop-helix DNA-binding domain protein family Achaete-scute/HLH T05G5.3 ncc-1;CECDC2A;T05G5.3 Serine/threonine protein kinase required for mitosis; putative ortholog of human CDC2 and S. cerevisiae Cdc28p cyclin-dependent serine/threonine protein kinases serine/threonine kinase (CDC2/CDKX subfamily); cdk-1 encodes a cyclin-dependent kinase, orthologous to and functionally interchangeable with CDC28 from S. cerevisiae; CDK-1 is required for cell-cycle progression through M phase in both meiosis and mitosis. T05G5.4 T05G5.4 Protein of unknown function T05G5.5 T05G5.5 Member of the uncharacterized protein family UPF0038, has moderate similarity to uncharacterized C. albicans Orf6.7418p Hypothetical protein A (T. aquaticus); This gene encodes a protein predicted by Eisenberg and coworkers, with 52% accuracy, to be mitochondrial. T05G5.6 T05G5.6 Protein with high similarity to short chain enoyl-Coenzyme A hydratase 1 (rat Echs1), which catalyzes the hydration of trans-2-enoyl-CoA forming 3-hydroxyacyl-CoA in fatty acid beta-oxidation, member of the enoyl-CoA hydratase or isomerase family Enoyl-CoA hydratase T05G5.7 T05G5.7 Protein of unknown function, has moderate similarity to uncharacterized C. elegans C27H6.4 T05G5.8 T05G5.8 Protein with weak similarity to S. cerevisiae Vps53p, which is a subunit of the VFT S. cerevisiae Sac2p, S. cerevisiae Vps53p, S. cerevisiae Luv1p complex that is involved in protein sorting in the late Golgi T05G5.9 T05G5.9 Protein containing a large coiled-coil domain and a putative golgi-localization (GRIP) domain Coiled coil protein T05H10.1 T05H10.1 Member of the ubiquitin carboxyl-terminal hydrolase family 2, which are cysteine proteases involved in deubiquination, has a region of low similarity to a region of S. cerevisiae Ubp15p, which is a putative ubiquitin-specific protease ubiquitin carboxyl-terminal hydrolase T05H10.2 apn-1;CeAPN1;T05H10.2 Member of the apurinic or apyrimidinic (AP) endonuclease family 2, which cleave DNA at AP sites, has a region of moderate similarity to AP endonuclease (S. cerevisiae Apn1p), which is a DNA (apurinic or apyrimidinic site) lyase (3'-repair diesterase) AP endonuclease (family 2); apn-1 encodes a member of the AP (apurinic or apyrimidinic) endonuclease family. T05H10.3 T05H10.3 Protein of unknown function, has weak similarity to C. elegans C35A5.3 T05H10.4 T05H10.4 Protein of unknown function T05H10.5 T05H10.5 Putative ortholog of S. cerevisiae Ufd2p, a ubiquitin fusion degradation protein T05H10.6 T05H10.6 Member of the dehydrogenase E1 component protein family pyruvate dehydrogenase E1 alpha subunit; T05H10.6 encodes an ortholog of the human gene PYRUVATE DEHYDROGENASE (LIPOAMIDE) ALPHA 1 (PDHA1; OMIM:312170), which when mutated leads to Leigh syndrome (OMIM:256000); the T05H10.6 protein is predicted to be mitochondrial with 68% accuracy. T05H10.7 T05H10.7 Protein of unknown function, putative paralog of C. elegans K10B3.6 glycerophosphoryl diester phosphodiesterase domain T05H10.8 T05H10.8 Protein of unknown function T05H4.1 T05H4.1 Putative acyltransferase, possible paralog of C. elegans ZK40.1 T05H4.10 T05H4.10 Protein of unknown function, has similarity to human KIAA0539 protein (isolated from a brain cDNA library) T05H4.11 T05H4.11 Protein of unknown function T05H4.12 T05H4.12 Protein of unknown function T05H4.13 T05H4.13 Member of the aldehyde dehydrogenase protein family aldehyde dehydrogenase T05H4.14 T05H4.14 Protein containing six WD domains (WD-40 repeat), which may mediate protein-protein interactions, has a region of low similarity to a region of S. pombe Tup12p, which is a transcriptional repressor functioning redundantly with S. pombe Tup11p The gad-1 gene encodes a WD repeat-containing protein that is required maternally for gastrulation initiation during early embryogenesis by regulating the division timing, spindle orientation, and subsequent inward migration of the two gut precusor (E) cells at the 26-cell stage. T05H4.15 T05H4.15 Member of an uncharacterized protein family T05H4.2 T05H4.2 Member of an uncharacterized protein family This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins; this gene's encoded protein also contains an FTH/DUF38 motif, which may also mediate protein-protein interaction. T05H4.3 T05H4.3 Protein containing nine leucine rich repeats, which mediate protein-protein interactions, has a region of low similarity to a region of adenylate cyclase (S. cerevisiae Cyr1p), which generates cAMP in response to ras activation T05H4.4 T05H4.4 Member of the cytochrome b5 reductase protein family NADH-cytochrome B5 reductase; The T05H4.4 gene encodes a homolog of the human gene B5R, which when mutated leads to methemoglobinemia (OMIM:250800). T05H4.5 T05H4.5 Member of the cytochrome b5 reductase protein family NADH-cytochrome B5 reductase; The T05H4.5 gene encodes an ortholog of the human gene NADH-CYTOCHROME B5 REDUCTASE (DIA1), which when mutated leads to methemoglobinemia (OMIM:250800). T05H4.6 T05H4.6 Protein with high similarity to eukaryotic translation termination factor 1 (human ETF1), which is an RNA binding translation release factor involved in translation termination, member of the eukaryotic release factor 1 (eRF1) family eukaryotic peptide chain release factor subunit 1 T05H4.7 T05H4.7 Member of the plant chitinase class I family, which hydrolyze the beta-1,4-N-acetyl-D-glucosamine bonds in chitin polymers destroying chitin-containing cell walls of fungal and insect pathogens, has high similarity to uncharacterized C. elegans C08B6.4 chitinase T05H4.8 T05H4.8 Protein of unknown function, has moderate similarity to C. elegans C01G10.13 T05H4.9 T05H4.9 Member of the transposase protein family T06A1.1 T06A1.1 Protein containing a DUF138 domain of unknown function, has high similarity to uncharacterized C. elegans C05C8.8 T06A1.2 T06A1.2 Member of the 7-transmembrane chemoreceptor family of G-protein coupled receptors (GPCR), has weak similarity to C. elegans ODR-10, which is involved in odorant response 7TM chemoreceptor, srj family T06A1.3 T06A1.3 Protein of unknown function T06A1.4 T06A1.4 Protein of unknown function T06A1.5 T06A1.5 Protein containing a DUF138 domain of unknown function, has high similarity to uncharacterized C. elegans C31B8.7 T06A10.2 T06A10.2 Putative ortholog of C. elegans Y116A8A.Y gene product T06A10.3 T06A10.3 Putative ortholog of C. elegans Y116A8A.Z gene product T06A10.4 T06A10.4 Protein with strong similarity to C. elegans Y116A8A.Z gene product T06A4.1 T06A4.1 Putative zinc carboxypeptidase, has strong similarity to human carboxypeptidases carboxypeptidase T06A4.2 T06A4.2 Protein of unknown function T06A4.3 T06A4.3 Member of the metallocarboxypeptidase protein family carboxypeptidase T06C10.2 T06C10.2 Protein of unknown function, has weak similarity to C. elegans T28A11.15 7TM chemoreceptor, srt family T06C10.3 T06C10.3 Putative tyrosine protein kinase, has similarity to human and D. melanogaster FER (fps/fes-related) protein kinases T06C10.4 flp-10;T06C10.4 Putative FMRF-amide neurotransmitter T06C10.5 T06C10.5 Member of the reverse transcriptase protein family, which are RNA-dependent DNA polymerases, has very strong similarity to uncharacterized C. elegans B0302.3 T06C10.6 kin-26;Cehd-22;T06C10.6 Putative tyrosine protein kinase, has similarity to human and D. melanogaster FER (fps/fes-related) protein kinases tyosine-protein kinase T06C12.1 T06C12.1 Member of the 7-transmembrane chemoreceptor family of G-protein coupled receptors (GPCR), has low similarity to C. elegans ODR-10, which is involved in odorant response 7TM receptor T06C12.10 T06C12.10 Protein with moderate similarity to UDP-glucose ceramide glucosyltransferase (glucosylceramide synthase, rat Ugcg), which converts UDP-glucose and ceramide to glucosylceramide in glycosphingolipid biosynthesis and may be involved in apoptosis T06C12.11 T06C12.11 Member of the 7-transmembrane chemoreceptor family of G-protein coupled receptors (GPCR), has low similarity to C. elegans ODR-10, which is a G protein-coupled receptor involved in odorant response 7TM receptor T06C12.12 T06C12.12 Protein of unknown function, has weak similarity to C. elegans F59G1.1 T06C12.13 T06C12.13 Protein containing a nuclear hormone receptor ligand-binding domain and a nuclear hormone receptor C4-type zinc finger domain, which bind DNA and may be involved in regulation of transcription, has low similarity to C. elegans NHR-58 Zinc finger, C4 type (two domains) T06C12.14 T06C12.14 Protein containing a DUF18 domain of unknown function, has strong similarity to uncharacterized C. elegans F35E8.9 T06C12.2 T06C12.2 Member of the 7-transmembrane chemoreceptor family of G-protein coupled receptors (GPCR), has weak similarity to C. elegans ODR-10, which is a G protein-coupled receptor involved in odorant response 7TM receptor T06C12.3 T06C12.3 Member of the 7-transmembrane chemoreceptor family of G-protein coupled receptors (GPCR), has high similarity to uncharacterized C. elegans T06C12.2 7TM receptor T06C12.4 T06C12.4 Protein containing a DUF38 domain of unknown function, has moderate similarity to C. elegans T07D3.1, which may function in germ-line stem cell differentiation and body size regulation T06C12.5 T06C12.5 Member of an uncharacterized protein family T06C12.6 T06C12.6 Protein containing a nuclear hormone receptor ligand-binding domain and a nuclear hormone receptor C4-type zinc finger domain, which bind DNA and may be involved in regulation of transcription, has low similarity to C. elegans NHR-58 Zinc finger, C4 type (two domains) T06C12.7 nhr-84;T06C12.7 Member of the nuclear hormone receptor/Zinc finger protein family Zinc finger, C4 type (two domains) T06C12.8 T06C12.8 Protein containing a DUF33 domain of unknown function, has high similarity to uncharacterized C. elegans F37C4.3 T06C12.9 T06C12.9 Member of the uncharacterized protein family UPF0057, has high similarity to uncharacterized C. elegans R10D12.7 T06D10.1 T06D10.1 Protein of unknown function, has strong similarity to C. elegans T06D10.E T06D10.2 T06D10.2 Protein with moderate similarity to C. elegans F36H12.3 T06D4.1 T06D4.1 Protein of unknown function T06D4.2 T06D4.2 Protein of unknown function T06D4.3 T06D4.3 Member of the protease protein family T06D4.3 encodes a neprilysin; neprilysins are thermolysin-like zinc metallopeptidases, found on the outer surface of animal cells, that negatively regulate small signalling peptides (e.g., enkephalin, tachykinin, insulin, and natriuretic peptides) by cleaving them; T06D4.3 has no clear orthologs in other organisms. T06D4.4 T06D4.4 Member of the protease protein family T06D4.4 encodes a neprilysin; neprilysins are thermolysin-like zinc metallopeptidases, found on the outer surface of animal cells, that negatively regulate small signalling peptides (e.g., enkephalin, tachykinin, insulin, and natriuretic peptides) by cleaving them; T06D4.4 has no clear orthologs in other organisms. T06D8.1 T06D8.1 Putative coiled-coil protein, has weak similarity to human GRAVIN, a putative scaffold protein involved in localization of kinases, also has weak similarity to human and S. cerevisiae mucins T06D8.10 T06D8.10 Member of the animal heme peroxidase family, which catalyze biosynthetic and degradative reactions using hydrogen peroxide as the electron acceptor, has a region of moderate similarity to a region of human D2S448, which is involved in the immune response peroxidase T06D8.2 T06D8.2 Protein containing a UvrB-uvrC motif, which are involved in incision of the damaged strand during E. coli DNA repair T06D8.3 T06D8.3 Member of the phosphatidic acid phosphatase-related (PAP2) phosphoesterase family, has a region of low similarity to phosphatidic acid phosphatase 2b (human PPAP2B), which dephosphorylates phosphatidic acid to diacylglycerol in glycerolipid biosynthesis T06D8.4 T06D8.4 Member of the transposase family, which are required for excising and inserting mobile genetic elements, has very strong similarity to uncharacterized C. elegans C14A6.4 transposase T06D8.5 T06D8.5 Putative ortholog of S. cerevisiae Cox15p, a protein required for cytochrome oxidase assembly YER141W; This gene encodes a protein predicted by Eisenberg and coworkers, with 52% accuracy, to be mitochondrial. T06D8.6 T06D8.6 Protein with high similarity to holocytochrome c synthase (cytochrome c heme-lyase, human HCCS), member of the cytochrome C and C1 heme lyase family, which catalyze covalent attachment of a heme group onto cytochromes C and C1 cyctochrome c1 heme lyase T06D8.7 T06D8.7 Protein of unknown function T06D8.8 rpn-9;T06D8.8 Putative non-ATPase subunit of the 19S particle of the 26S proteasome complex, possible ortholog of human 26S proteasome subunit p40.5, PSMD13 (Hs.18700) rpn-9 is predicted to encode a non-ATPase subunit of the 19S regulatory complex of the proteasome that that affects body morphology, embryonic viability, locomotion, larval viability, fertility, and growth; interacts with RPN-11 in yeast two-hybrid assays. T06D8.9 T06D8.9 Protein of unknown function, has low similarity to uncharacterized human MGC8721 T06E4.1 hcp-2;T06E4.1 Predicted centromeric protein involved in chromosome segregation T06E4.10 T06E4.10 Protein of unknown function, has weak similarity to C. elegans T06E4.8 T06E4.11 T06E4.11 Protein of unknown function, has weak similarity to human KIAA0181 protein (Hs.159613) The protein product of this gene is predicted to contain a glutamine/asparagine (Q/N)-rich ('prion') domain, by the algorithm of Michelitsch and Weissman (as of the WS77 release of WormBase, i.e., in wormpep77). T06E4.3 atl-1;Ce-atl1;T06E4.3 Involved in chromosome stability, believed to function in a DNA damage checkpoint pathway phosphatidylinositol 3-kinase; The atl-1 gene encodes a large, 2514-residue protein of the ATM family, homologous to human AT (OMIM:208900, mutated in ataxia telangiectasia); the C-terminal sequence of ATL-1 contains a PI-3 kinase-like domain; ATL-1 is required for survival through early embryogenesis and normal chromosomal segregation; atl-1 is expressed in both the mitotic and meiotic cells of adult gonads. T06E4.4 T06E4.4 Protein containing two collagen triple helix repeats and one nematode cuticle collagen N-terminal domain, has moderate similarity to a region of C. elegans BLI-1, which is a putative collagen involved in embryogenesis and morphogenesis and chemotaxis collagen T06E4.5 T06E4.5 Protein of unknown function, has weak similarity to C. elegans T01C3.5 T06E4.6 T06E4.6 Protein containing two collagen triple helix repeats and one nematode cuticle collagen N-terminal domain, has moderate similarity to a region of C. elegans BLI-1, which is a putative collagen involved in embryogenesis and morphogenesis and chemotaxis collagen T06E4.7 T06E4.7 Protein of unknown function, has weak similarity to human mucin MUC1 T06E4.8 T06E4.8 Protein of unknown function, has moderate similarity to C. elegans T06E4.9 T06E4.9 T06E4.9 Protein of unknown function, has moderate similarity to C. elegans T06E4.8 T06E6.1 T06E6.1 Protein of unknown function, has weak similarity to human U5 snRNP-specific 40 kDa protein (HPRP8BP), has weak similarity to S. cerevisiae Ygl111p T06E6.10 T06E6.10 Protein containing a trypsin inhibitor-like cysteine rich domain, has high similarity to uncharacterized C. elegans Y69H2.3 T06E6.11 T06E6.11 Protein containing a DUF40 domain of unknown function, which contain four conserved cysteines, has high similarity to uncharacterized C. elegans T19C9.1 7TM receptor, srbc family T06E6.12 T06E6.12 Member of the 7-transmembrane chemoreceptor family of G-protein coupled receptors (GPCR), has high similarity to uncharacterized C. elegans T06E6.9 T06E6.13 T06E6.13 Protein containing a DUF38 domain of unknown function, has low similarity to a region of feminization of germline 2 (C. elegans FOG-2), which is required for the sexual identity of germ cells T06E6.2 T06E6.2 Member of the cyclin B protein family cyclin B like; cyb-3 encodes a member of the cyclin B family that is required for embryonic viability, and may be involved with sister chromatid segregation. T06E6.3 T06E6.3 Protein of unknown function, putative paralog of C. elegans C03A7.5 7 transmembrane receptor (rhodopsin family); srx-40 encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins; this gene's encoded protein also contains an FTH/DUF38 motif, which may also mediate protein-protein interaction. T06E6.4 T06E6.4 Member of the 7-transmembrane chemoreceptor family of G-protein coupled receptors (GPCR), has high similarity to uncharacterized C. elegans T09E8.5 7TM chemoreceptor, sri family T06E6.5 T06E6.5 Protein containing two DUF38 domains of unknown function and an F-box domain, which serves as a link between a target protein and a ubiquitin-conjugating enzyme, has weak similarity to uncharacterized C. elegans K10G4.1 This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins; this gene's encoded protein also contains an FTH/DUF38 motif, which may also mediate protein-protein interaction. T06E6.6 T06E6.6 Member of the 7-transmembrane chemoreceptor family of G-protein coupled receptors (GPCR), has high similarity to uncharacterized C. elegans T06E6.8 T06E6.7 T06E6.7 Member of the 7-transmembrane chemoreceptor family of G-protein coupled receptors (GPCR), has moderate similarity to uncharacterized C. elegans T06E6.8 T06E6.8 T06E6.8 Member of the 7-transmembrane chemoreceptor family of G-protein coupled receptors (GPCR), has high similarity to uncharacterized C. elegans T06E6.9 T06E6.9 T06E6.9 Member of the 7-transmembrane chemoreceptor family of G-protein coupled receptors (GPCR), has high similarity to uncharacterized C. elegans T06E6.8 T06E8.1 T06E8.1 Member of the phospholipid and glycerol acyltransferase family, has moderate similarity to lysophosphatidic acid acyltransferase-alpha (1-acyl sn-glycerol-3-phosphate acyltransferase, human AGPAT1), which changes lysophosphatidic acid to phosphatidic acid 1-acyl-SN-glycerol-3-phophate acyltransferase; T06E8.1 is orthologous to the human gene 1-ACYLGLYCEROL-3-PHOSPHATE O-ACYLTRANSFERASE 2 (LYSOPHOSPHATIDIC ACID ACYLTRANSFERASE, BETA) (AGPAT2; OMIM:603100), which when mutated leads to disease; T06E8.1 protein is predicted to be mitochondrial. T06E8.2 T06E8.2 Protein of unknown function T06F4.1 T06F4.1 Protein of unknown function T06F4.2 clc-4;clh-4;T06F4.2 Chloride channel protein chloride channel protein; A homolog of a mammalian CIC-type chloride channel that is uniquely expressed in adult worms. T06G6.1 T06G6.1 Member of C. elegans Sra integral membrane protein family, which contain 6-7 hydrophobic, putative transmembrane, regions, has high similarity to uncharacterized C. elegans F28C12.5 7TM chemoreceptor, sra family T06G6.11 T06G6.11 Thioredoxin Thioredoxin ; FYVE zinc finger T06G6.2 T06G6.2 Protein of unknown function, has high similarity to uncharacterized C. elegans F28C12.4, 7TM chemoreceptor, sra family T06G6.3 T06G6.3 Putative coiled-coil protein, has weak similarity to myosins T06G6.4 T06G6.4 Protein with weak similarity to S. cerevisiae IMH1 (Probable coiled-coil protein, single copy and multicopy suppressor of ypt6) T06G6.5 T06G6.5 Protein of unknown function, has moderate similarity to C. elegans F23A7.6 T06G6.6 T06G6.6 Protein of unknown function T06G6.7 T06G6.7 Protein of unknown function, has moderate similarity to uncharacterized C. elegans Y46H3C.3 7TM chemoreceptor, srw family T06G6.8 T06G6.8 Protein of unknown function, has weak similarity to C. elegans Y47H9B.2 T06G6.9 T06G6.9 Protein with moderate similarity to von Hippel-Lindau binding protein 1 (human VBP1), which forms a complex with the tumor suppressor von Hippel-Lindau protein (human VHL) and may regulate its intracellular localization Human VHL binding protein like T06H11.1 twk-18;T06H11.1 Member of the 4 TM potassium channel protein family unc-58 encodes one of 44 C. elegans TWK (two-P domain K+) potassium channel subunits that contain two pore-forming domains and four transmembrane domains; unc-58 was originally defined by gain-of-function (gf) mutations that result in paralysis and a shortened (dumpy) body morphology due to hypercontraction of body wall muscle; unc-58 gf mutations also result in constitutive egg-laying; as loss of UNC-58 function via reversion or RNA-mediated interference (RNAi) results in either no abnormalities or only a weakly uncoordinated phenotype, UNC-58 likely functions redudantly with other TWK channels to regulate locomotion and egg-laying; UNC-58 is expressed in motor neurons and interneurons. T06H11.2 T06H11.2 Protein of unknown function T06H11.3 T06H11.3 Protein of unknown function T06H11.4 T06H11.4 Member of the molybdenum cofactor biosynthesis protein family, has moderate similarity to a region of gephyrin (human GPHN), which is a tubulin binding protein that mediates clustering of GABA(A) receptors and is an autoantigen in Stiff Man Syndrome gephyrin; moc-1 encodes an ortholog of human GEPHYRIN (GPHN; OMIM:603930), which when mutated leads to molybdenum cofactor (MoCo) deficiency; MOC-1 is also paralogous to LIN-46. T07A5.1 T07A5.1 Protein with strong similarity to C. elegans T07D3.4 gene product T07A5.2 T07A5.2 Protein of unknown function, has high similarity to uncharacterized rat Rn.3446 YK10 homolog T07A5.3 T07A5.3 Protein with similarity to human and D. melanogaster sodium-dependent inorganic phosphate cotransporters, member of the major facilitator superfamily sodium/phosphate transporter protein T07A9.1 T07A9.1 Protein with low similarity to polyglutamine binding protein 1 (human PQBP1), which is a transcriptional co-activator that binds polyglutamine tracts of many proteins and may act in mRNA synthesis, ubiquitination, cell cycle control, and RNA splicing T07A9.10 T07A9.10 Member of the Sec 1 family, has low similarity to syntaxin-binding protein 1 (human STXBP1), which binds syntaxins and may be involved in synaptic vesicle exocytosis acetylcholine regulator T07A9.11 T07A9.11 Member of the ribosomal S24e family, which are part of the small ribosomal subunit, has a region of high similarity to ribosomal protein S24 (S. cerevisiae Rps24Bp), which is a ribosomal structural protein ribosomal protein; rps-24 encodes a small ribosomal subunit S24 protein; by homology, RPS-24 is predicted to function in protein biosynthesis; in C. elegans, RPS-24 activity is required for germline development and the overall health of the animal. T07A9.12 T07A9.12 Protein of unknown function T07A9.13 T07A9.13 Protein of unknown function T07A9.2 T07A9.2 Member of the class I glutamyl and glutaminyl (E and Q) tRNA synthetase family, has moderate similarity to mitochondrial glutamyl-tRNA synthetase (S. cerevisiae Mse1p), which is involved in aerobic respiration tRNA synthetase; ers-3 encodes a a glutamine (E)/glutaminyl (Q) tRNA synthetase. T07A9.3 T07A9.3 Protein with high similarity to mitogen-activated protein kinase 10 (human MAPK10), which phosphorylates c-Jun (human JUN) in response to cellular stressors such as ultraviolet light and osmotic stress, contains a protein kinase domain protein kinase T07A9.5 T07A9.5 Member of the exonuclease family, contains two SAP domains, which may bind DNA T07A9.6 daf-18;T07A9.6 Involved in dauer formation; related to human PTEN tumor suppressor daf-18 encodes a lipid phosphatase homologous to the human PTEN tumor suppresor (OMIM:601728, mutated in Cowden disease and several cancers); DAF-18 negatively regulates insulin-like signaling mediated by DAF-2/IR and AGE-1/PI3K and thus plays a role in metabolism, development, and longevity; based on sequence and genetic analysis, DAF-18 is predicted to dephosphorylate AGE-1-generated PIP3 in order to limit activation of the downstream AKT-1 and AKT-2 kinases that negatively regulate DAF-16. T07A9.7 gpa-4;T07A9.7 Member of the G protein alpha subunit family guanine nucleotide-binding protein; gpa-4 encodes a member of the G protein alpha subunit family of heterotrimeric GTPases; it is expressed in ASI. T07A9.8 T07A9.8 Protein with low similarity to S. cerevisiae Rrp8p, which cleaves pre-rRNA at site A2 during ribosomal RNA processing T07A9.9 T07A9.9 Putative ortholog of S. cerevisiae Ypl093p, a protein of unknown function T07C12.1 T07C12.1 Member of the 7-transmembrane chemoreceptor family of G-protein coupled receptors (GPCR), has low similarity to C. elegans ODR-10, which is a G protein-coupled receptor involved in odorant response T07C12.10 T07C12.10 Protein of unknown function, has weak similarity to C. elegans Y4C6A.I T07C12.11 T07C12.11 Protein of unknown function T07C12.2 T07C12.2 Member of the reverse transcriptase protein family, which are RNA-dependent DNA polymerases, has very strong similarity to uncharacterized C. elegans F28E10.3 reverse transcriptase T07C12.3 T07C12.3 Protein with strong similarity to C. elegans T07C12.1 gene product T07C12.5 T07C12.5 Protein with similarity to G protein-coupled receptors of the ODR-10 subfamily, has fewer than 7 transmembrane domains, no homolog found in human or D. melanogaster T07C12.6 T07C12.6 Member of the C. elegans Sre G protein-coupled chemoreceptor family, which are putative chemosensory receptors, has moderate similarity to uncharacterized C. elegans Y57A10C.3 7TM receptor, sre family T07C12.7 T07C12.7 Member of the transthyretin-like family, has high similarity to uncharacterized C. elegans C56A3.2 Transthyretin-like family T07C12.8 T07C12.8 Protein of unknown function, has weak similarity to C. elegans CD4.5 T07C12.9 T07C12.9 Member of the NNMT, PNMT or TEMT family of methyltransferases, has low similarity to nicotinamide N-methyltransferase (human NNMT), which transfers a S-adenosyl L-methionine methyl group to nicotinamide and other substrates N-methyltransferase T07C4.1 T07C4.1 Member of the orotidine 5'-phosphate (OMP) decarboxylase family, contains a phosphoribosyl transferase domain, has moderate similarity to uridine monophosphate (UMP) synthase (orotate phosphoribosyl transferase and orotidine-5'-decarboxylase, human UMPS) UMP synthase; T07C4.1 is orthologous to the human gene URIDINE MONOPHOSPHATE SYNTHETASE (OROTATE PHOSPHORIBOSYL TRANSFERASE AND OROTIDINE-5'-DECARBOXYLASE) (UMPS; OMIM:258900), which when mutated leads to disease. T07C4.10 T07C4.10 Putative coiled-coil protein, has weak similarity to S. cerevisiae Uso1p, required for protein transport from ER to Golgi T07C4.2 tbx-8;T07C4.2 Member of the T-box protein family Brachyury T07C4.3 T07C4.3 Protein of unknown function T07C4.4 T07C4.4 Protein with similarity to bactericidal amoebapores that may act as an antibacterial agent spp-1 encodes a predicted transmembrane protein containing a saposin (B) domain that is a member of a saposin-like protein superfamily containing mammalian NK-lysin and granulysin and the protozoan amoebapores; SPP-1 is predicted to function as a lipid-binding protein with cytotoxic, pore-forming activity, and in vitro, does exhibit antibacterial activity; loss of SPP-1 function via RNA-mediated interference (RNAi) does not, however, result in any abnormalities. T07C4.5 T07C4.5 Member of the transthyretin-like family, has high similarity to uncharacterized C. elegans Y5F2A.1 Transthyretin-like family T07C4.6 tbx-9;T07C4.6 Member of the T-box protein family Brachyury T07C4.7 mev-1;cyt-1;T07C4.7 Cytochrome b560, cytochrome b subunit of succinate dehydrogenase (complex II) of the electron transporter chain Succinate dehydrogenase cytochrome b chain; mev-1 is orthologous to the human gene SUCCINATE DEHYDROGENASE COMPLEX, SUBUNIT C, INTEGRAL MEMBRANE PROTEIN, 15KD (SDHC; OMIM:602413), which when mutated leads to familial nonchromaffin paragangliomas type 3. T07C4.8 ced-9;T07C4.8 Inhibitor of programmed cell death; protein with similarity to human Bcl-2 Apoptosis regulator proteins, Bcl-2 family; ced-9 is required for control of programmed cell death during development; it encodes the only C. elegans homolog of BCL-2. T07C4.9 nex-2;T07C4.9 Member of the annexin family, which exhibit calcium-dependent phospholipid binding, has moderate similarity to annexin VII (synexin) (human ANXA7), which is a calcium-dependent GTPase that acts as a voltage-dependent calcium channel Annexin; nex-2 encodes an annexin, a member of a family of calcium-dependent phospholipid binding proteins; by homology, NEX-2 could function in a number of processes, such as membrane fusion, cytoskeletal interactions, and intracellular signaling; however, as loss of nex-2 function via RNA-mediated interference (RNAi) does not result in any abnormalities, the precise role of NEX-2 in C. elegans development and/or behavior is not yet known. T07C5.1 T07C5.1 Protein containing a UDP-glucoronosyl and UDP-glucosyl transferase domain, has low similarity to UDP-glucuronosyltransferase 8 (UDP glycosyltransferase 8, UDP-galactose ceramide galactosyltransferase, rat Ugt8), which acts in galactosylceramide synthesis UDP-glucuronosyltransferase T07C5.2 T07C5.2 Protein containing a nuclear hormone receptor ligand-binding domain, has low similarity to C. elegans NHR-51 Ligand-binding domain of nuclear hormone receptors, Zinc finger, C4 type (two domains) T07C5.3 T07C5.3 Protein containing a nuclear hormone receptor ligand-binding domain, has low similarity to C. elegans NHR-51 Ligand-binding domain of nuclear hormone receptors T07C5.4 T07C5.4 Protein containing a nuclear hormone receptor ligand-binding domain, has moderate similarity to uncharacterized C. elegans F16H9.2 T07C5.5 T07C5.5 Protein containing two nuclear hormone receptor C4-type zinc finger domains, which bind DNA and may be involved in regulation of transcription, and a nuclear hormone receptor ligand-binding domain, has low similarity to C. elegans NHR-51 Ligand-binding domain of nuclear hormone receptors, Zinc finger, C4 type (two domains) T07D1.1 gcy-31;T07D1.1 Putative soluble guanylyl cyclase guanylate cyclase T07D1.2 T07D1.2 Protein of unknown function, has low similarity to uncharacterized human FLJ13910 T07D1.3 T07D1.3 Protein of unknown function T07D1.4 fox-1;T07D1.4 RNA-binding protein involved in establishment or assessment of the X:A ratio for sex determination and dosage compensation RNA-binding protein T07D1.5 T07D1.5 Protein of unknown function T07D10.1 T07D10.1 Protein of unknown function T07D10.2 T07D10.2 Member of the rhodopsin family of G-protein coupled receptors (GPCR), has low similarity to v1a vasopressin receptor (rat Avpr1a), which mobilizes intracellular calcium through phosphoinositide hydrolysis conopressin receptor like; T07D10.2 is orthologous to the human gene VASOPRESSIN RECEPTOR TYPE 2 (AVPR2; OMIM:304800), which when mutated leads to nephrogenic diabetes insipidus. T07D10.3 T07D10.3 Protein of unknown function, putative paralog of C. elegans H16D19.3 zinc finger protein T07D10.4 H16D19.1;T07D10.4 Member of the C-type lectin protein family C-type lectin T07D10.5 H16D19.2;T07D10.5 Member of the C-type lectin protein family T07D3.1 T07D3.1 Protein which may function in germ-line stem cell differentiation, has strong similarity to rat GERp95 T07D3.2 T07D3.2 Protein of unknown function, has low similarity to uncharacterized C. elegans F10A3.11 T07D3.3 T07D3.3 Protein with moderate similarity to C. elegans T07D3.9 T07D3.4 T07D3.4 Protein of unknown function, has a region of low similarity to a region of Fukuyama type congenital muscular dystrophy (human FCMD), which acts in neuronal migration and brain and muscle development and is associated with Fukuyama-type muscular dystrophy T07D3.4 is orthologous to the human gene FUKUTIN (FCMD; OMIM:253800), which when mutated leads to disease. T07D3.5 T07D3.5 Protein with strong similarity to C. elegans T07D3.4 gene product T07D3.6 T07D3.6 Protein of unknown function, putative paralog of C. elegans T07D3.4 T07D3.7 alg-2;T07D3.7 Piwi-related protein with a role in the production of stRNA (small temporal RNA) lin-4 from its precursor; functionally overlaps with ALG-1 alg-2 encodes a PAZ and PIWI-domain containing protein that is a member of the highly conserved eukaryotic RDE-1/AGO1/PIWI family of proteins that regulate posttranscriptional gene silencing (PTGS); ALG-2 functions with ALG-1 to control specific developmental timing events by positively regulating expression of small temporal RNAs (stRNAs) encoded by lin-4 and let-7; ALG-2 and ALG-1 are also required for RNAi in the germline, although they are not required for RNAi in the soma. T07D3.8 T07D3.8 TcA transposase transposase T07D3.9 T07D3.9 Putative paralog of C. elegans F57F4.1 gene product T07D4.1 T07D4.1 Member of the rhodopsin family of G-protein coupled receptors (GPCR), has weak similarity to cholecystokinin A receptor (human CCKAR), which stimulates phospholipase C, regulates contraction and secretion and is associated with obesity and diabetes G-protein coupled receptor T07D4.2 T07D4.2 Protein of unknown function, has strong similarity to human C11ORF8/Hs.46638 gene product possibly associated with mental retardation component of the WAGR syndrome T07D4.3 T07D4.3 Putative RNA helicase ATP-dependent RNA helicase; rha-1 encodes an ATP-dependent DEAD/H box RNA helicase orthologous to human RNA helicase A and Drosophila Maleless, an essential component of the dosage compensation machinery required for increased X-linked transcription in males; by homology, RHA-1 is predicted to function in regulation of transcription, translation, RNA processing, and/or RNA replication; in C. elegans, RHA-1 is required for germ cell proliferation, normal germ cell nuclear morphology, RNA-mediated interference (RNAi) of germline-expressed genes, and silencing of germline-expressed transgenes; RHA-1 is reported to localize to the nucleus and the cytoplasm. T07D4.4 T07D4.4 Member of the DEAD or DEAH box ATP-dependent RNA helicase family and contains two helicase conserved C-terminal domains, has low similarity to C. elegans GLH-1, which is an RNA helicase that localizes to P granules ATP-dependent helicase (DEAD box) T07E3.1 T07E3.1 Member of the reverse transcriptase protein family, which are RNA-dependent DNA polymerases, has high similarity to uncharacterized C. elegans C49D10.1 T07E3.2 T07E3.2 Protein of unknown function, has weak similarity to C. elegans T07C12.10 T07E3.3 T07E3.3 Protein of unknown function T07E3.4 T07E3.4 Protein containing an F-box domain, which serve as a link between a target protein and a ubiquitin-conjugating enzyme This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins. T07E3.5 T07E3.5 Protein which contains a single BRC motif that is also present in the human tumor suppressor protein BRCA2 The T07E3.5 gene encodes a single BRC domain (in residues 12-109) that might promote double-stranded DNA break repair; eight tandem BRC domains are encoded by the central coding region of the human BRCA2 gene, which when mutated leads to early-onset breast cancer 2 or hereditary male breast cancer (OMIM:600185). T07E3.6 T07E3.6 Protein of unknown function T07E3.7 T07E3.7 Protein with weak similarity to H. sapiens TRIP11 gene product [thyroid hormone receptor interactor 11 (GenBank)] T07F10.1 T07F10.1 Member of the M1 peptidase family of aminopeptidases, has low similarity to aminopeptidase N (aminopeptidase M, rat APN), which is a zinc metallopeptidase that converts angiotensin III to angiotensin IV and is involved in regulatory peptide degradation aminopeptidase N T07F10.2 T07F10.2 Protein of unknown function, has moderate similarity to C. elegans T24A6.2 T07F10.3 T07F10.3 Protein containing two RNA recognition motifs (RRM, RBD, or RNP), has a region of low similarity to a region of rat Secp43, which is a protein that associates with tRNA selenocysteine and may act in the selenocysteine incorporation pathway polyadenylate-binding protein like T07F10.4 T07F10.4 Protein of unknown function, has moderate similarity to uncharacterized human MGC15397 Human mRNA (KIAA0033) like protein T07F10.5 T07F10.5 Member of an uncharacterized protein family T07F10.6 T07F10.6 Protein of unknown function T07F12.1 T07F12.1 Member of the phosphoglycerate mutase family T07F12.2 T07F12.2 Protein containing a PA (protease associated) domain T07F12.3 T07F12.3 Protein of unknown function, has weak similarity to C. elegans Y17G7B.14 T07F12.4 T07F12.4 Protein containing a protein kinase domain, has low similarity to S. pombe Pef1p, which is a putative cyclin-dependent serine-threonine protein kinase that is involved in G1 to S phase transition Serine/Threonine protein kinase T07F12.5 T07F12.5 Protein of unknown function T07F8.1 T07F8.1 Member of an uncharacterized protein family T07F8.2 T07F8.2 Member of the rhodopsin family of G-protein coupled receptors (GPCR), has weak similarity to somatostatin receptor 2 (rat Sstr2), which inhibits adenylyl cyclase and mediates the inhibition of secretion of growth hormone (rat Gh1) and glucagon (rat Gcg) T07F8.3 T07F8.3 Protein of unknown function T07F8.4 T07F8.4 Protein containing an Egl-27 and MTA1 homology 2 (ELM2) domain, which may be involved in DNA or protein-protein binding, and a Myb-like DNA-binding domain, has high similarity to uncharacterized C. elegans F10E7.11 T07G12.1 T07G12.1 Member of an uncharacterized protein family calmodulin; cal-4 encodes one of five predicted C. elegans calcium-binding calmodulin homologs (the others being CAL-1, CAL-2, CAL-3 and CMD-1); as loss of cal-4 function via RNA-mediated interference (RNAi) does not result in any abnormalities, the precise role of CAL-4 in C. elegans development and/or behavior is not yet known; based on sequence similarity however, CAL-4 is predicted to function, perhaps redundantly, in cellular processes dependent upon calcium, such as cell signaling and muscle contraction. T07G12.10 T07G12.10 Putative paralog of C. elegans T07G12.9, contains a C2H2-type zinc finger domain Zinc finger, C2H2 type T07G12.11 T07G12.11 Putative paralog of C. elegans T07G12.10, contains a C2H2-type zinc finger domain Zinc finger, C2H2 type T07G12.12 T07G12.12 Protein of unknown function, has moderate similarity to C. elegans T07G12.10 Zinc finger, C2H2 type T07G12.13 T07G12.13 Putative ortholog of C. elegans T07G12.9 gene product T07G12.2 T07G12.2 Member of the nucleobase transporter protein family permease T07G12.3 T07G12.3 Member of uncharacterized DUF229 family, has moderate similarity to uncharacterized C. elegans Y73F8A.35 T07G12.4 T07G12.4 Member of the xanthine or uracil permeases family of membrane transporters, has low similarity to solute carrier family 23 member 1 (human SLC23A1), which catalyzes sodium-dependent uptake of L-ascorbic acid permease T07G12.5 T07G12.5 Member of the nucleobase transporter protein family permease T07G12.6 T07G12.6 Putative ortholog of C. elegans T07G12.11 gene product T07G12.7 T07G12.7 Protein of unknown function, has strong similarity to uncharacterized C. elegans R07H5.6 TC5 transposase T07G12.8 T07G12.8 Protein of unknown function T07H3.1 T07H3.1 Protein containing two BTB (BR-C, ttk and babor) or POZ (Pox virus and zinc finger) domains, which are found in some DNA and actin binding proteins and may mediate protein-protein interactions, and two meprin and TRAF homology (MATH) domains T07H3.2 T07H3.2 Protein containing a BTB (BR-C, ttk and babor) or POZ (Pox virus and zinc finger) domain, which are found in some DNA and actin binding proteins and may mediate protein-protein interactions, and a meprin and TRAF homology (MATH) domain T07H3.3 T07H3.3 Protein containing two meprin and TRAF homology (MATH) domains T07H3.4 T07H3.4 Member of the C-type lectin protein family T07H3.5 T07H3.5 Member of the C-type lectin protein family T07H3.6 T07H3.6 Protein containing a meprin and TRAF homology (MATH) domain, has low similarity to uncharacterized C. elegans R52.1 T07H6.1 T07H6.1 Member of the carboxylesterase protein family esterase T07H6.2 mom-1;bop-1;T07H6.2 Protein required for polarization of the EMS blastomere; has similarity to D. melanogaster Porcupine which is involved in secretion of Wingless mom-1 encodes a predicted O-acyltransferase that is orthologous to Porcupine proteins conserved across a wide range of species; MOM-1 functions as part of a Wnt/MAPK signaling pathway that is required maternally for endoderm induction in the early embryo; by homology, MOM-1 is predicted to be a membrane-spanning endoplasmic reticulum protein that stimulates post-translational processing of Wnt signaling molecules such as MOM-2; embryonic mosaic analysis indicates that MOM-1 activity is required in the signaling cell, P2, for proper specification of endoderm, consistent with its predicted role in processing MOM-2/Wnt. T07H6.3 T07H6.3 Protein containing two collagen triple helix repeats, which are found in some extracellular proteins, and a nematode cuticle collagen N-terminal domain, has moderate similarity to C. elegans ROL-8 collagen T07H6.4 T07H6.4 Protein containing seven sushi or short consensus repeat (SCR) domains, which are found in complement and adhesion proteins, has weak similarity to a region of complement receptor 1 (human CR1), which is a regulator of complement activation sushi repeats T07H6.5 T07H6.5 Protein containing seven sushi or short consensus repeat (SCR) domains, which are found in complement and adhesion proteins, has low similarity to complement component 4-binding protein alpha chain (human C4BPA), which is associated with thromoembolism T07H6.6 T07H6.6 Protein with strong similarity to C. elegans R173.3 gene product T07H8.1 T07H8.1 Member of the rhodopsin family of G-protein coupled receptors (GPCR), has high similarity to uncharacterized C. elegans C47A10.8 7TM chemoreceptor, srx family T07H8.2 T07H8.2 Putative G protein-coupled receptor, no homolog found in human or D. melanogaster 7TM chemoreceptor, srx family T07H8.3 T07H8.3 Protein of unknown function, has high similarity to uncharacterized C. elegans K09D9.10 7TM chemoreceptor, srx family T07H8.4 T07H8.4 Member of the EGF-repeat protein family T07H8.5 T07H8.5 Protein with weak similarity to members of the SRG subfamily of G protein-coupled receptors 7TM chemoreceptor, srg family T07H8.6 ptr-15;T07H8.6 Member of the patched family, which are transmembrane receptors, has weak similarity to a region of Niemann-Pick disease type C1 (human NPC1), which plays a role cholesterol transport and is associated with Niemann-Pick disease upon gene mutation ptr-15 encodes a member of the Patched superfamily. T07H8.7 T07H8.7 Member of the C. elegans Sre G protein-coupled chemoreceptor family, which are putative chemosensory receptors, has moderate similarity to uncharacterized C. elegans F10D2.3 7TM chemoreceptor, sre family T08A11.1 T08A11.1 Protein of unknown function, has a region of weak similarity to a region of S. cerevisiae Iml1p, which has a role in stability of artificial minichromosomes T08A11.2 T08A11.2 Putative ortholog of S. cerevisiae Ymr288p, a predicted spliceosomal protein T08A9.1 T08A9.1 Protein of unknown function keratin; T08A9.1 is orthologous to the human gene LIKELY ORTHOLOG OF MOUSE COILED COIL FORMING PROTEIN 1 (RB1CC1; OMIM:606837), which when mutated leads to disease. T08A9.10 T08A9.10 Protein with similarity to bactericidal amoebapores that may act as an antibacterial agent spp-6 encodes a predicted transmembrane protein containing a saposin (B) domain that is a member of a saposin-like protein superfamily containing mammalian NK-lysin and granulysin and the protozoan amoebapores; SPP-6 is predicted to function as a lipid-binding protein that may possess pore-forming, cytotoxic activity; as loss of SPP-6 function via RNA-mediated interference (RNAi) does not result in any abnormalities, the precise role of SPP-6 in C. elegans development and/or behavior is not yet known. T08A9.2 T08A9.2 Member of the transthyretin-like family, has low similarity to uncharacterized C. elegans F22A3.2 T08A9.3 sng-1;T08A9.3 Has moderate similarity to human synaptogyrins synaptogyrin T08A9.4 T08A9.4 Protein containing an F-box domain, which serve as a link between a target protein and a ubiquitin-conjugating enzyme This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins. T08A9.5 T08A9.5 Protein of unknown function, has moderate similarity to C. elegans T10C6.10 T08A9.6 T08A9.6 Protein containing an F-box domain, which serve as a link between a target protein and a ubiquitin-conjugating enzyme This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins. T08A9.7 T08A9.7 Protein with similarity to bactericidal amoebapores that may act as an antibacterial agent T08A9.8 T08A9.8 Protein with similarity to bactericidal amoebapores that may act as an antibacterial agent T08A9.9 T08A9.9 Protein with similarity to bactericidal amoebapores that may act as an antibacterial agent spp-5 encodes a predicted transmembrane protein containing a saposin (B) domain that is a member of a saposin-like protein superfamily containing mammalian NK-lysin and granulysin and the protozoan amoebapores; SPP-5 is predicted to function as a lipid-binding protein that may possess pore-forming,cytotoxic activity; loss of SPP-5 function via RNA-mediated interference (RNAi) can result in larval lethality, suggesting that SPP-5 activity may be required for postembryonic development. T08B1.1 T08B1.1 ember of the sugar (and other) transporter family, has weak similarity to human SLC22A4, which is a proton-organic cation transporter that transports various organic cations efficiently in a pH-dependent manner sugar transporter T08B1.2 T08B1.2 Member of the troponin family, which regulate calcium-induced muscle contraction, has moderate similarity to troponin T (C. elegans MUP-2), which is involved in epidermal differentiation T08B1.3 T08B1.3 Protein with high similarity to cytosolic aldehyde dehydrogenase class 3 (mouse Aldh3a1), which oxidizes aromatic aldehydes and medium-chain aliphatic aldehyde products of lipid peroxidation, member of the aldehyde dehydrogenase family aldehyde dehydrogenase T08B1.4 T08B1.4 Member of the lipase class 3 family, which are a subset of lipolytic enzymes that hydrolyze ester linkages of triglycerides, has low similarity to uncharacterized C. elegans Y110A7A.7 T08B1.5 T08B1.5 Protein of unknown function, has moderate similarity to C. elegans Y66A7A.1 T08B1.6 T08B1.6 Member of the AMP-binding enzyme family, has moderate similarity to acyl-CoA synthetase 5 (human FACL5), which catalyzes the synthesis of acyl-CoA from fatty acids, ATP, and CoA long-chain fatty-acid CoA ligase T08B2.10 T08B2.10 Member of the ribosomal protein S17 protein family 40S ribosomal protein S17; rps-17 encodes a small ribosomal subunit S17 protein. T08B2.11 T08B2.11 Member of a protein family T08B2.12 T08B2.12 Putative paralog of C. elegans C48E7.7 gene product T08B2.2 T08B2.2 Protein containing two collagen triple helix repeats, has moderate similarity to a region of C. elegans BLI-1, which is a putative collagen involved in embryogenesis and morphogenesis and chemotaxis T08B2.3 T08B2.3 Protein with strong similarity to C. elegans F53C3.9 gene product T08B2.4 T08B2.4 Protein of unknown function, has weak similarity to C. elegans K10D2.2 T08B2.5 T08B2.5 Putative RNA-binding protein, contains an RRM (RNA recognition motif) domain and C2H2-type zinc finger domain, has similarity to human putative tumor suppressor (LUCA15) protein, has similarity to human RNA binding motif protein 5 (RBM5) T08B2.7 T08B2.7 Putative alpha subunit of mitochondrial fatty acid beta-oxidation trifunctional protein (enoyl-CoA hydratase/3-hydroxyacyl-CoA dehydrogenase), possible ortholog of human HADHA (Hs.75860) 3-hydroxyacyl-CoA dehydrogenase T08B2.8 T08B2.8 Protein of unknown function, has low similarity to mitochondrial ribosomal protein L23 (human MRPL23), which is a putative RNA-binding mitochondrial large ribosome subunit that is likely to play a role in protein biosynthesis T08B2.9 T08B2.9 Protein with high similarity to phenylalanine-tRNA synthetase-like (human FARSL), which is the alpha subunit of phenylalanine-tRNA synthetase that aminoacylates phenylalanyl-tRNA, member of the class II phenylalanyl (F)-tRNA synthetase family phenylalanyl-tRNA synthetase; frs-1 encodes a predicted phenylalanyl-t-RNA synthetase. T08B6.1 T08B6.1 Protein of unknown function, has weak similarity to C. elegans T08B6.5 T08B6.2 T08B6.2 Member of the phospholipase A2 receptor protein family T08B6.3 T08B6.3 Member of the 7-transmembrane chemoreceptor family of G-protein coupled receptors (GPCR), has low similarity to C. elegans ODR-10, which is involved in odorant response 7TM chemoreceptor, str family T08B6.4 T08B6.4 Protein of unknown function, possible paralog of C. elegans F58D2.2 T08B6.5 T08B6.5 Protein containing an RNA recognition motif (RRM, RBD, or RNP), has a region of high similarity to a region of poly(A)-binding protein (nuclear 1, human PABPN1), which stimulates poly(A) tail synthesis and and may play a role in nuclear export of mRNAs RNA binding protein T08B6.6 T08B6.6 Member of the 7-transmembrane chemoreceptor family of G-protein coupled receptors (GPCR), has low similarity to C. elegans ODR-10, which is involved in odorant response 7TM chemoreceptor, str family T08B6.7 T08B6.7 Member of the 7-transmembrane chemoreceptor family of G-protein coupled receptors (GPCR), has high similarity to uncharacterized C. elegans T01G5.5 7TM chemoreceptor, str family T08B6.8 T08B6.8 Protein with similarity to G protein-coupled receptors of the ODR-10 subfamily, has fewer than 7 transmembrane domains, no homolog found in human or D. melanogaster T08D10.1 T08D10.1 Member of the CCAAT-binding transcription factor (CBF-B or NF-YA) subunit B family, which are involved in subunit interaction and DNA-binding, has a region of moderate similarity to a region of nuclear transcription factor Y alpha (mouse Nfya) DNA binding protein T08D10.2 T08D10.2 Member of the flavin containing amine oxidase family, has moderate similarity to uncharacterized C. elegans Y40B1B.6 corticosteroid-binding protein T08D10.3 T08D10.3 Protein of unknown function T08D2.2 T08D2.2 Putative paralog of C. elegans Y60A3A.14 T08D2.3 T08D2.3 ATP-dependent helicase ATP-dependent helicase (DEAD box), Zinc finger, CCHC class (3 domains) T08D2.4 T08D2.H;T08D2.4 Protein containing a C3HC4 type (RING) zinc finger, which may mediate protein-protein interactions Zinc finger, C3HC4 type (RING finger) T08D2.5 T08D2.I;T08D2.5 Protein of unknown function, has high similarity to uncharacterized C. elegans T12F5.2 T08D2.7 Ce-cds-2;T08D2.7 Strongly similar to C. elegans CDS-1; similar to D. melanogaster Dmnk-related kinase; may be required for meiotic recombination Forkhead-associated (FHA) domain ; Eukaryotic protein kinase domain T08D2.8 T08D2.L;T08D2.8 Protein of unknown function, has a region of low similarity to a region of C. elegans ZYG-9, which is a microtubule-associated protein (MAP) protein that is a component of meiotic and mitotic spindle poles T08E11.1 T08E11.1 Protein containing four DUF38 domains of unknown function, and two F-box domains, which serve as a link between a target protein and a ubiquitin-conjugating enzyme, has high similarity to uncharacterized C. elegans ZK250.5 This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins; this gene's encoded protein also contains an FTH/DUF38 motif, which may also mediate protein-protein interaction. T08E11.2 T08E11.2 Protein containing two meprin and TRAF homology (MATH) domains, has high similarity to uncharacterized C. elegans T08E11.3 T08E11.3 T08E11.3 Protein containing two meprin and TRAF homology (MATH) domains, has high similarity to uncharacterized C. elegans T08E11.2 T08E11.4 T08E11.4 Protein containing four meprin and TRAF homology (MATH) domains T08E11.5 T08E11.5 Member of an uncharacterized protein family T08E11.6 T08E11.6 Protein containing an F-box domain, which serve as a link between a target protein and a ubiquitin-conjugating enzyme, has high similarity to uncharacterized C. elegans C08F1.3 This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins; its encoded protein also contains a Pfam-B45 motif of presently unknown function. T08E11.7 T08E11.7 Protein containing a DUF38 domain of unknown function and an F-box domain, which serve as a link between a target protein and a ubiquitin-conjugating enzyme, has low similarity to C. elegans FOG-2, which is required for the sexual identity of germ cells This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins; this gene's encoded protein also contains an FTH/DUF38 motif, which may also mediate protein-protein interaction. T08E11.8 T08E11.8 Protein containing two DUF38 domains of unknown function, has high similarity to uncharacterized C. elegans ZK250.5 T08G11.1 T08G11.1 Putative ortholog of S. cerevisiae Vps13p, a nonessential protein involved in vacuolar sorting nucleotide binding protein T08G11.2 T08G11.2 Protein contains a putative SH2 (Src homology 2) domain, is a member of an uncharacterized protein family egl-32 encodes a novel protein that contains an SH2 domain highly similar to C. briggsae CBP06632 and affects egg laying, development of the male gonad and germline, and chemosensation mediated by the AWC neurons with slight effects on chemosensation mediated by the AWA neurons; may be partially functional within the TGF beta signaling pathway with respect to egg-laying and is required during the L4 larval stage for egg laying. T08G11.3 T08G11.3 Protein of unknown function, has weak similarity to C. elegans Y55F3C_751.C T08G11.4 T08G11.4 Protein of unknown function, has a region of high similarity to a region of nuclear receptor coactivator 6 interacting protein (human NCOA6IP), which is a ligand-dependent nuclear receptor transcription co-activator and putative RNA methyltransferase T08G11.5 unc-29;unc-56;T08G11.5 Acetylcholine receptor family subunit acetylcholine receptor, beta precursor; unc-29 encodes an non-alpha subunit of the nicotinic acetylcholine receptor (nAChR) superfamily; UNC-29 is required for normal locomotion and egg-laying, and functions as a subunit of a ligand-gated ion channel that likely mediates fast actions of acetylcholine at neuromuscular junctions and in the nervous system; when coexpressed with LEV-1, a non-alpha nAChR subunit, and UNC-38 or UNC-63, alpha AChR subunits, the resulting multimer can form levamisole-gated channels; UNC-29 is expressed in body wall muscle. T08G2.2 T08G2.2 Protein of unknown function, has strong similarity to C. elegans ZK1055.2 T08G2.3 T08G2.3 Protein with high similarity to medium chain acyl-coenzyme A dehydrogenase (human ACADM), which is involved in fatty acid beta-oxidation and possibly energy pathways and is associated with medium-chain acyl-CoA dehydrogenase deficiency upon gene mutation acyl-CoA dehydrogenase; T08G2.3 is orthologous to the human gene ACYL-CoA DEHYDROGENASE, MEDIUM-CHAIN (ACADM; OMIM:607008), which when mutated leads to MCAD deficiency. T08G3.1 T08G3.1 Member of the 7-transmembrane chemoreceptor family of G-protein coupled receptors (GPCR), has low similarity to C. elegans ODR-10, which is involved in odorant response T08G3.10 T08G3.10 G protein-coupled receptor of unknown function, has weak similarity to human somatostatin receptor 7TM chemoreceptor, srw family T08G3.11 T08G3.11 Protein of unknown function, has weak similarity to C. elegans F57E7.2 T08G3.2 T08G3.2 Member of the 7-transmembrane chemoreceptor family of G-protein coupled receptors (GPCR), has low similarity to C. elegans ODR-10, which is a G protein-coupled receptor involved in odorant response T08G3.3 T08G3.3 Member of the 7-transmembrane chemoreceptor family of G-protein coupled receptors (GPCR), has high similarity to uncharacterized C. elegans F26D2.4 T08G3.4 T08G3.4 Member of the C-lectin binding domain protein family T08G3.5 T08G3.5 Member of the 7-transmembrane chemoreceptor family of G-protein coupled receptors (GPCR), has high similarity to uncharacterized C. elegans T08G3.3 T08G3.6 T08G3.6 Protein of unknown function, has strong similarity to C. elegans F58F9.6 T08G3.7 T08G3.7 Protein containing a BRCA1 (breast cancer type 1) C terminus (BRCT) domain, which are found in some cell cycle checkpoint proteins, and one ankyrin (Ank) repeat, has high similarity to uncharacterized C. elegans F36D3.5 Ank repeat, BRCA1 C Terminus (BRCT) domain T08G3.8 T08G3.8 Protein containing a DUF215 domain of unknown function, has moderate similarity to uncharacterized C. elegans F23B12.2 T08G3.9 T08G3.9 Member of the G protein-coupled receptor protein family T08G5.1 T08G5.1 Protein of unknown function T08G5.10 mtl-2;CeMT-II;met-II;MTCe-1;MTCe-2;T08G5.10 Metallothionein-related, cadmium-binding protein mtl-2 encodes a metallothionein, a small, cysteine-rich, metal-binding protein; MTL-2 functions in metal detoxification and homeostasis and stress adaptation; MTL-2 expression is induced in larval and adult intestinal cells following exposure to cadmium or heat stress; MTL-2 intestinal expression is dependent upon ELT-2, an intestine-specific GATA-type transcription factor. T08G5.2 T08G5.2 Protein containing a protein kinase domain, has a region of low similarity to a region of fer (fps/fes related) tyrosine kinase (human FER), which may serve in cell signaling, growth and adhesion, and is associated with prostatic proliferative diseases tyrosine-protein kinase T08G5.3 T08G5.3 Protein of unknown function, has weak similarity to C. elegans D1086.1 T08G5.5 T08G5.5 Protein of unknown function, has weak similarity to a region of TGF beta receptor associated protein-1 (human TRAP-1), which associates with inactive Type I TGF beta receptor (human TGFBR1) and interacts with human Smad4 T08G5.7 T08G5.7 Protein containing three C2H2 type zinc finger domains, which bind nucleic acids Zinc finger, C2H2 type (3 domains) T08G5.8 T08G5.8 Protein of unknown function, putative paralog of C. elegans T08G5.9 T08G5.9 T08G5.9 Protein of unknown function, putative paralog of C. elegans T08G5.8 T08H10.1 T08H10.1 Member of the aldo-keto reductase family, which include some related monomeric NADPH-dependent oxidoreductases, has moderate similarity to aldehyde reductase (rat Akr1a1), which is an aldehyde reductase that reduces carbonyl-containing substrates aldose reductase T08H10.3 T08H10.3 Protein of unknown function, has strong similarity to uncharacterized C. elegans E03H12.7 T08H10.4 T08H10.4 Protein containing a DUF33 domain of unknown function T08H4.1 T08H4.1 Protein containing a RhoGEF (GTPase exchange factor) domain, has a region of weak similarity to a region of rho guanine nucleotide exchange factor 1 (human ARHGEF1), which is involved in cell cycle control and cell proliferation T08H4.2 T08H4.2 Protein of unknown function T08H4.3 T08H4.3 Protein containing an ETS domain, has a region of high similarity to a region of friend leukemia virus integration 1 (human FLI1), which is a transcription factor associated with Ewing sarcoma and related primitive neuroectodermal tumors ETS protein T09A12.1 T09A12.1 Putative ortholog of C. elegans C17E4.1 gene product T09A12.2 T09A12.2 Protein with high similarity to glutathione peroxidase 4 (phospholipid hydroperoxide glutathione peroxidase, mouse Gpx4), which is an selenoprotein that protects membrane phospholipids against peroxidation, member of the glutathione peroxidase family glutathione peroxidase T09A12.3 T09A12.3 Putative 7 transmembrane domain channel protein, has strong similarity to osm-9 gene product [Predicted six transmembrane domain channel protein required for mechanosensation, AWA-mediated olfactory responses, AWC-mediated olfactory adaptation, and ASH-mediated avoidance responses] ocr-2 encodes a TRPV (transient receptor potential channel, vanilloid subfamily) ion channel; OCR-2 activity is required for several types of sensory transduction including olfaction, osmosensation, mechanosensation, and chemosensation; an OCR-2 fusion protein is expressed in sensory cilia and requires the OSM-9 TRPV channel protein for proper localization; likewise, OSM-9 requires OCR-2 for its cilial localization. T09A12.4 nhr-66;T09A12.4 Putative nuclear hormone receptor, has similarity to human and D. melanogaster hepatocyte nuclear factors zinc finger protein T09A5.1 T09A5.1 Putative calcium-binding protein, has similarity to D. melanogaster sarcoplasmic calcium-binding protein SCP2, has similarity to C. elegans F56D1.6 calcium binding protein T09A5.10 lin-5;T09A5.10 Genetic locus that is required for mitotic cell divisions lin-5 encodes a novel protein with a centrally located alpha-helical coiled-coil domain and ten potential proline-directed kinase phosphorylation sites; LIN-5 activity is required for mitosis and cytokinesis at all stages of development, specifically for spindle positioning, chromosome alignment and segregation, and perhaps also for blocking exit from mitosis when chromosome segregation fails; LIN-5, which is expressed maternally, embryonically, and during larval stages, localizes to the cell periphery and, in microtubule-dependent manner, to the meiotic spindle and the asters and kinetochore microtubules of the mitotic spindle; in regulating spindle function, LIN-5 interacts with two G protein regulators, GPR-1 and GPR-2, which require LIN-5 activity for localization to the spindle and cell cortex; additionally, LIN-5 interacts in vitro with itself, the coiled-coil protein LFI-1, GEI-16, and several other novel proteins; genetic studies indicate that in regulating embryonic spindle function, lin-5 acts downsteam of par-2, par-3, mes-1, and src-1 and upstream of gpr-1, gpr-2, goa-1, and gpa-16. T09A5.11 T09A5.11 Protein with weak similarity to S. cerevisiae Wbp1p, which is the oligosaccharyltransferase beta subunit and is involved in the transfer of core oligosaccharide from dolichol carrier to Asn-X-Ser/Thr motif N-oligosaccharyl transferase 48kd subunit T09A5.12 T09A5.12 Protein containing two C2H2 type zinc finger domains, which bind nucleic acids Zinc finger, C2H2 type (2 domains) T09A5.2 klp-3;T09A5.2 Member of the kinesin C-terminal motor domain protein family, possibly involved in chromosome movement and segregation including that of the sex chromosomes kinesin like protein; klp-3 encodes a kinesin-like motor protein orthologous to Saccharomyces cerevisiae Kar3 and Drosophila NcD, minus-end-directed motors with C-terminal ATP- and microtubule-binding domains; KLP-3 plays a role in chromosome movement and segregation and is required for germline and embryonic development; KLP-3 binds microtubules and in newly hatched larvae is expressed in only the specialized epithelial marginal cells of the pharynx and cells in the posterior gut near the anal region. T09A5.3 acr-7;T09A5.3 Member of the acetylcholine receptor protein family, has moderate similarity to C. elegans ACR-16, which is a nicotinic acetylcholine receptor alpha-1 subunit Acetylcholine receptor; acr-7 encodes an alpha-7-like homomer-forming subunit of the nicotinic acetylcholine receptor (nAChR) superfamily which encode ligand-gated ion channels that regulate fast action of acetylcholine at neuromuscular junctions and in the nervous system; ACR-7 is expressed pharyngeal muscle and in tail neurons distal to the anus, and is a member of the ACR-16-like group of nAChR subunits. T09A5.4 T09A5.4 Protein of unknown function T09A5.5 T09A5.5 Protein of unknown function T09A5.6 T09A5.6;CeMed10;CeNut2 Component of the Mediator complex required for transcriptional regulation of certain genes T09A5.7 T09A5.7;2I146 Protein with weak similarity to S. cerevisiae YKL053C-A T09A5.8 T09A5.8 Protein containing a Chromo domain, which bind chromatin chromosomal organisation modifier protein T09A5.9 T09A5.9 Protein containing nine leucine rich repeats, which mediate protein-protein interactions, has moderate similarity to S. pombe Sds22p, which is a protein phosphatase PP1 regulatory subunit that plays a role in mitosis SDS22 protein T09B4.1 T09B4.1 Protein of unknown function, has weak similarity to uncharacterized human FLJ20477 T09B4.10 T09B4.10 Protein containing six TPR (tetratrico peptide repeat) domains, which may mediate protein-protein interactions, has moderate similarity to STIP1 homology and U-box containing protein 1 (mouse Stub1), which interacts with the carboxyl terminus of HSC70 T09B4.2 T09B4.2 Protein with strong similarity to C. elegans Y37A1B.14 gene product T09B4.3 T09B4.3 Protein of unknown function T09B4.4 T09B4.4 Putative calcium-binding protein, has similarity to calmodulins and human caltractin (CALT) T09B4.5 T09B4.5 Protein with weak similarity to H. sapiens Hs.169504 (Human mRNA for KIAA0170 gene, complete cds) T09B4.6 T09B4.6 Protein of unknown function SER/THR-protein kinase T09B4.7 T09B4.7 Protein containing a protein kinase domain, has weak similarity to C. elegans Y106G6E.6, which is a putative serine-threonine protein kinase involved in embryogenesis and morphogenesis T09B4.8 T09B4.8 Member of the aminotransferase protein family aminotransferase T09B4.9 T09B4.9 Protein with low similarity to S. cerevisiae Tim44p, which is a mitochondrial inner membrane protein required in transport across the inner membrane T09B9.2 T09B9.2 Protein with similarity to human and D. melanogaster sodium-dependent inorganic phosphate cotransporters, member of the major facilitator superfamily Sodium/phosphate transporter T09B9.3 T09B9.3 Protein of unknown function, has weak similarity to uncharacterized C. elegans ZC155.4 T09B9.4 T09B9.4 Protein with strong similarity to human D10S170, involved in rearrangement of the RET proto-oncogene T09B9.4 is orthologous to the human gene PUTATIVE CYTOSKELETAL PROTEIN (D10S170; OMIM:601985), which when mutated leads to disease. T09B9.5 T09B9.5 Protein of unknown function T09D3.1 T09D3.1 Protein of unknown function, has moderate similarity to uncharacterized C. elegans C39H7.7 7TM chemoreceptor, srd family T09D3.2 T09D3.2 Member of the C. elegans Srg family of integral membrane proteins, which may be involved in chemosensation 7TM chemoreceptor, srg family T09D3.3 T09D3.3 Protein containing two uncharacterized DUF139 cysteine repeat domains T09D3.4 T09D3.4 Protein containing a nuclear hormone receptor C4-type zinc finger domain, which bind DNA and may be involved in regulation of transcription, has weak similarity to C. elegans NHR-58, which is involved in embryogenesis and morphogenesis nuclear hormone receptor T09D3.5 T09D3.5 Member of the C. elegans Srg family of integral membrane proteins, has low similarity to uncharacterized C. elegans C10G8.1 7TM chemoreceptor, srg family T09E11.1 T09E11.1 Protein with moderate similarity to glucuronyltransferase-P (beta-1,3-glucuronyltransferase 1, rat GlcAT-P), which is involved in the synthesis of the HNK-1 carbohydrate epitope on glycoproteins and in cell adhesion during nervous system development Carbohydate phosphorylases T09E11.10 T09E11.10 Member of an uncharacterized protein family T09E11.11 T09E11.11 Protein of unknown function, has strong similarity to C. elegans C47F8.3 T09E11.2 nhr-A;T09E11.2 Member of the zinc finger protein family of the nuclear receptor superfamily Zinc finger, C4 type (two domains) T09E11.3 T09E11.3 Member of an uncharacterized protein family T09E11.4 T09E11.4 Putative G protein-coupled receptor, member of a subfamily with distant similarity to members of the SRG subfamily, no homolog found in human or D. melanogaster T09E11.5 T09E11.5 Putative G protein-coupled receptor, member of a subfamily with distant similarity to members of the SRG subfamily, no homolog found in human or D. melanogaster T09E11.6 T09E11.6 Protein containing an acetylglucosaminyltransferase-like domain, has similarity across the C-terminal region to human glucosaminyl (N-acetyl) transferases acetylglucosaminyltransferase-like domain T09E11.7 T09E11.7 Putative G protein-coupled receptor, member of a subfamily with distant similarity to members of the SRG subfamily, no homolog found in human or D. melanogaster T09E11.8 T09E11.8 Protein of unknown function, putative paralog of C. elegans F18F11.4 T09E11.9 T09E11.9 Member of the core-2 or I-branching enzyme family, which form blood group I-antigens or side-chains of O-glycans, has weak similarity to core 2 beta-1,6-N-acetylglucosaminyltransferase (rat Gcnt1), which forms O-glycan branched structures acetylglucosaminyltransferase-like domain T09E8.1 T09E8.1 Protein with weak similarity to C. elegans F58G4.1 (Putative myosin heavy chain, has strong similarity to human, D. melanogaster and C. elegans myosin heavy chain protein) T09E8.2 T09E8.2 Protein of unknown function him-17 encodes a novel chromatin-associated protein required for initiation of meiotic recombination via the formation of double-strand DNA breaks; him-17 mutants have inviable embryos and a high frequency of males in the population; the HIM-17::GFP fusion protein localizes to chromatin in germline nuclei. T09E8.3 T09E8.3 Protein with low similarity to S. cerevisiae Erv14p, which is a protein of ER-derived vesicles that is required for efficient degradation of soluble ER quality control substrates cornichon protein like T09E8.4 T09E8.4 Protein of unknown function, has strong similarity to C. elegans F54E2.5 7 transmembrane receptor (rhodopsin family) T09E8.5 T09E8.5 Member of the 7-transmembrane chemoreceptor family of G-protein coupled receptors (GPCR), has high similarity to uncharacterized C. elegans T06E6.4 7TM chemoreceptor, sri family T09F3.1 T09F3.1 Protein containing two C2H2 type zinc finger domains, which bind nucleic acids Zinc finger, C2H2 type T09F3.2 T09F3.2 Member of the mitochondrial carrier protein family of membrane transporters, has low similarity to replication in mitochondria 2 (S. cerevisiae Rim2p), which is a mitochondrial carrier membrane transporter that is required for respiration carrier protein C2 T09F3.3 gpd-1;T09F3.3 Glyceraldehyde-3-phosphate dehydrogenase; embryonic form glyceraldehyde 3-phosphate dehydrogenase 1; gpd-1 encodes one of four C. elegans glyceraldehyde-3-phosphate dehydrogenases (GAPDHs); by homology, GPD-1 is predicted to reversibly catalyze the oxidation and phosphorylation of glyceraldehyde-3-phosphate to 1,3-diphosphoglycerate during glycolysis; GPD-1 is required for embryogenesis, normal body morphology, and gonad development; in C. elegans, GPD-1 and GPD-4 constitute the minor GAPDH isoenzymes and are expressed primarily in embryos, in all cell types. T09F3.4 T09F3.4 Protein of unknown function T09F5.1 T09F5.1 Member of an uncharacterized protein family T09F5.10 T09F5.10 Protein of unknown function, has high similarity to uncharacterized C. elegans K08A2_45.F T09F5.11 T09F5.11 Protein containing a DUF38 domain of unknown function and an F-box domain, which serve as a link between a target protein and a ubiquitin-conjugating enzyme, has low similarity to C. elegans FOG-2, which is required for the sexual identity of germ cells This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins; this gene's encoded protein also contains an FTH/DUF38 motif, which may also mediate protein-protein interaction. T09F5.2 T09F5.2 Protein of unknown function T09F5.3 T09F5.3 Member of the 7-transmembrane chemoreceptor family of G-protein coupled receptors (GPCR), has low similarity to C. elegans ODR-10, which is a G protein-coupled receptor involved in odorant response T09F5.5 T09F5.5 Member of the 7-transmembrane chemoreceptor family of G-protein coupled receptors (GPCR), has low similarity to uncharacterized C. elegans T27E7.2 T09F5.6 T09F5.6 Member of the 7-transmembrane chemoreceptor family of G-protein coupled receptors (GPCR) T09F5.7 T09F5.7 Protein of unknown function, putative paralog of C. elegans F54D8.5 reverse transcriptase T09F5.8 T09F5.8 Member of the 7-transmembrane chemoreceptor family of G-protein coupled receptors (GPCR), has high similarity to uncharacterized C. elegans K05D4.6 T09F5.9 T09F5.9 Member of the C-type lectin family, has weak similarity to human LY75 lymphocyte antigen and C-type mannose receptor MRC1 C-type lectin T09H2.1 T09H2.1 Member of the cytochrome P450 family, has low similarity to cytochrome P450 subfamily 2C polypeptide 8 (mephenytoin 4-hydroxylase, human CYP2C8), which is a heme-binding monooxygenase that metabolizes steroids, fatty acids, and xenobiotics cytochrome P450 T10A3.1 T10A3.1 Protein containing four C2 domains, which may be involved in calcium-dependent phospholipid binding, and two PDZ, DHR, or GLGF domains, which are found in signaling proteins, has low similarity to rab3 interacting molecule 2 (rat Rim2) C2 domain of protein kinase C; unc-10 encodes a protein with zinc-finger, Q/N-rich, PDZ, and C2 domains that is homologous to vertebrate Rim1, a presynaptic protein which binds, and effects the activity of, synaptic vesicle-associated GTP-Rab3; UNC-10 is required for normal locomotion and synaptic transmission, and localizes to a subdomain of presynaptic termini, where it probably acts to regulate the priming step of presynaptic vesicle fusion by promoting conformational changes in syntaxin. T10B10.1 col-41;T10B10.1 Protein containing two collagen triple helix repeats and one nematode cuticle collagen N-terminal domain, has moderate similarity to a region of C. elegans BLI-1, which is a putative collagen involved in embryogenesis and morphogenesis and chemotaxis collagen T10B10.2 T10B10.2 Member of the insulinase (peptidase M16) family, which are divalent cation-dependent, has low similarity to beta (enhancing) subunit of mitochondrial processing peptidase (S. cerevisiae Mas1p) ubiquinol-cytochrome c reductase complex core protein 2; This gene encodes a protein predicted by Eisenberg and coworkers, with 52% accuracy, to be mitochondrial. T10B10.3 T10B10.3 Protein containing a pleckstrin homology (PH) domain, which mediate protein-protein and protein-lipid interactions T10B10.4 T10B10.4 Protein of unknown function T10B10.5 T10B10.5 Protein containing a C2 domain, which may be involved in calcium-dependent phospholipid binding, has low similarity to synaptotagmin 7 (human SYT7), which likely facilitates entry of Trypanosoma cruzi into cells via lysosomes synaptotagmin like T10B10.6 T10B10.6 Protein of unknown function T10B10.7 T10B10.7 Protein containing four ankyrin (Ank) repeats, which may mediate protein-protein interactions, has a region of moderate similarity to a region of C. elegans OSM-9, which is a predicted six transmembrane domain channel protein required for mechanosensation ankyrin repeats; ocr-3 encodes a predicted TRPV channel (transient receptor potential cation channel, subfamily V) containing six membrane-spanning regions, cytoplasmic ankyrin repeats, and a long, unconserved cytoplasmic tail that is related to the mammalian TRPV1 cation channel (OMIM:602076) activated by capsaicin and other noxious stimuli; although the precise role of OCR-3 in C. elegans development and/or behavior is not yet known, OCR-3 expression is detected solely in the rectal gland cells and occasionally the glial socket cells of the head, suggesting that OCR-3 may function in sensory signal transduction in these cell types. T10B10.8 T10B10.8 Putative glycogenin glycogenin like T10B10.9 T10B10.9 Protein of unknown function T10B11.1 T10B11.1 Member of the pterin 4 alpha carbinolamine dehydratase family factor 1 (TCF1), has a region of high similarity to dimerization cofactor of hepatocyte nuclear factor 1 alpha (mouse Pcbd), which is a transcription co-activator for mouse Tcf1 T10B11.1 is orthologous to the human gene 6-PYRUVOYL-TETRAHYDROPTERIN SYNTHASE or DIMERIZATION COFACTOR OF HEPATOCYTE NUCLEAR FACTOR 1 ALPHA (PCBD or TCF1; OMIM:126090), which when mutated leads to hyperphenylalaninemia with primapterinuria. T10B11.2 T10B11.2 Protein containing a diacylglycerol kinase catalytic domain (presumed), different forms of which have different affinities for diacylglycerol-containing substrates, has a region of low similarity to a region of sphingosine kinase 2 (human SPHK2) T10B11.3 T10B11.3 Protein containing two C2H2 type zinc finger domains, which bind nucleic acids, and an RNA recognition motif (RRM, RBD, or RNP) RNA-binding T10B11.4 T10B11.4 Protein of unknown function, has moderate similarity to uncharacterized C. elegans F37A8.2 T10B11.5 T10B11.5 Protein of unknown function, has low similarity to uncharacterized C. elegans T24H10.4 T10B11.6 T10B11.6 Protein of unknown function, has moderate similarity to uncharacterized C. elegans C09B8.4 T10B11.7 T10B11.7 Protein of unknown function T10B11.8 T10B11.8 Protein of unknown function, has weak similarity to C. elegans F27C8.5 T10B11.9 T10B11.9 Protein containing a CCCH-type zinc finger domain, which bind DNA or RNA T10B5.2 T10B5.2 Protein of unknown function, putative paralog of C. elegans K09C6.7 T10B5.3 T10B5.3 Protein of unknown function T10B5.4 T10B5.4 Protein of unknown function T10B5.5 T10B5.5 Protein with high similarity to chaperonin containing T-complex polypeptide-1 subunit 7 (mouse Cct7), which plays a role in protein folding, member of the tailless complex polypeptide or chaperonin cpn60 family T10B5.6 T10B5.6 Protein of unknown function T10B5.7 T10B5.7 Member of the lipase class 3 family, which are a subset of lipolytic enzymes that hydrolyze ester linkages of triglycerides, has high similarity to uncharacterized C. elegans F58B6.1 lipase T10B5.8 T10B5.8 Member of the NADH:flavin oxidoreductase or NADH oxidase family, which reduce a range of alternative electron acceptors, has weak similarity to C. albicans Ebp1p, which is an oxidoreductase with estrogen-binding properties NADH oxidase T10B5.9 T10B5.9 TcA transposase transposase T10B9.1 T10B9.1 Member of the cytochrome P450 family, has low similarity to cytochrome P450 subfamily 3a polypeptide 11 (mouse Cyp3a11), which is a steroid-inducible microsomal enzyme that catalyzes oxidation of tetrahydrocannabinol compounds and activates aflatoxin B1 cytochrome P450 T10B9.10 T10B9.10 Member of the cytochrome P450 family, has low similarity to cytochrome P450 subfamily 3a polypeptide 9 (rat Cyp3a9), which is a sexually dimorphically expressed enzyme that demethylates erythromycin and benzphetamine cytochrome P450; ccp-13A7 encodes a homolog of cytochrome P450 proteins; these proteins are membrane proteins with a heme prosthetic group that catalyse the synthesis of steroid hormones (and bile salts), and also detoxify foreign substances (xenobiotic compounds). T10B9.2 T10B9.2 Member of the cytochrome P450 family, has low similarity to cytochrome P450 subfamily 3a polypeptide 9 (rat Cyp3a9), which is a sexually dimorphically expressed enzyme that demethylates erythromycin and benzphetamine cytochrome P450 T10B9.3 T10B9.3 Member of the cytochrome P450 family, has low similarity to cytochrome P450 subfamily 3a polypeptide 11 (mouse Cyp3a11), which is a steroid-inducible microsomal enzyme that catalyzes oxidation of tetrahydrocannabinol compounds and activates aflatoxin B1 cytochrome P450 T10B9.4 T10B9.4 Member of the cytochrome P450 family, has low similarity to cytochrome P450 subfamily 3a polypeptide 9 (rat Cyp3a9), which is a sexually dimorphically expressed enzyme that demethylates erythromycin and benzphetamine cytochrome P450 T10B9.5 T10B9.5 Member of the cytochrome P450 family, has low similarity to cytochrome P450 subfamily 3a polypeptide 13 (mouse Cyp3a13), which is a liver enzyme that activates aflatoxin B1 to form a genotoxic product cytochrome P450 T10B9.7 T10B9.7 Member of the cytochrome P450 family, has low similarity to cytochrome P450 subfamily 3a polypeptide 9 (rat Cyp3a9), which is a sexually dimorphically expressed enzyme that demethylates erythromycin and benzphetamine cytochrome P450 T10B9.8 T10B9.8 Member of the cytochrome P450 family, has low similarity to cytochrome P450 subfamily 3a polypeptide 9 (rat Cyp3a9), which is a sexually dimorphically expressed enzyme that demethylates erythromycin and benzphetamine cytochrome P450 T10B9.9 T10B9.9 Protein of unknown function T10C6.1 T10C6.1 Member of the 7-transmembrane chemoreceptor family of G-protein coupled receptors (GPCR), has low similarity to C. elegans ODR-10, which is involved in odorant response 7TM receptor T10C6.10 T10C6.10 Protein containing an F-box domain, which serve as a link between a target protein and a ubiquitin-conjugating enzyme, has high similarity to uncharacterized C. elegans F29G9.7 This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins. T10C6.11 his-4;T10C6.11 Protein with high similarity to histone H2B (S. cerevisiae Htb1p), which binds chromatin and is involved in the stress response and repression of transcription, member of the histone family of nucleosomal core proteins histone H2B; his-4 encodes an H2B histone. T10C6.12 his-3;T10C6.12 Histone H3, core nucleosomal component histone H2A; his-3 encodes an H2A histone; by homology, HIS-3 is predicted to function as a nucleosome component required for packaging of DNA into chromatin; his-3 is a replication-dependent histone locus that resides in the HIS1 cluster on chromosome V. T10C6.13 his-2;T10C6.13 Member of the histone H3 protein family histone H3; his-2 encodes an H3 histone; his-2 is contained within the histone gene cluster HIS1. T10C6.14 his-1;T10C6.14 Member of the histone H4 protein family histone H4; his-1 encodes an H4 histone; his-1 is contained within the histone gene cluster HIS1; transcript analysis suggests that it encodes the major class of H4 transcripts. T10C6.2 T10C6.2 Member of the 7-transmembrane chemoreceptor family of G-protein coupled receptors (GPCR), has low similarity to C. elegans ODR-10, which is involved in odorant response 7TM receptor T10C6.3 T10C6.3 Protein of unknown function, has moderate similarity to uncharacterized C. elegans T10C6.4 7TM receptor, srx family T10C6.4 T10C6.4 Protein of unknown function, has moderate similarity to uncharacterized C. elegans T10C6.3 7TM receptor, srx family T10C6.5 T10C6.5 Protein of unknown function, has high similarity to uncharacterized human HSPC148 T10C6.6 T10C6.6 Member of the sugar (and other) transporter family, has moderate similarity to uncharacterized C. elegans T11G6.2 This gene encodes a protein predicted by Eisenberg and coworkers, with 52% accuracy, to be mitochondrial. T10C6.7 T10C6.7 Protein containing an F-box domain, which serve as a link between a target protein and a ubiquitin-conjugating enzyme, has moderate similarity to uncharacterized C. elegans T10C6.8 This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins. T10C6.8 T10C6.8 Protein containing an F-box domain, which serve as a link between a target protein and a ubiquitin-conjugating enzyme, has low similarity to uncharacterized C. elegans F08F3.6 T10C6.9 T10C6.9 Protein of unknown function, has strong similarity to uncharacterized C. elegans F29G9.7 T10D4.1 T10D4.1 Protein of unknown function, has moderate similarity to C. elegans R03H10.5 T10D4.10 T10D4.10 Member of the 7-transmembrane chemoreceptor family of G-protein coupled receptors (GPCR), has high similarity to uncharacterized C. elegans T10D4.9 7TM chemoreceptor, sri family T10D4.11 T10D4.11 Protein of unknown function, has weak similarity to C. elegans R03H10.5 T10D4.12 T10D4.12 Putative ortholog of C. elegans Y27F2A.7 gene product 7TM chemoreceptor, sri family T10D4.3 T10D4.3 Member of the glycosyl hydrolase 18 family, has weak similarity to chitinase 3-like 1 (cartilage glycoprotein-39, human CHI3L1), which binds chitin but lacks chitinase activity and is associated with rheumatoid arthritis synovial cells T10D4.4 T10D4.4 Protein of unknown function ins-31 encodes an insulin-like peptide of the insulin superfamily of proteins (OMIM:176730, 147440); INS-31 is one of 38 insulin-like peptides in C. elegans, but is unique in that it contains three insulin repeats; although overexpression with INS-19 can result in low levels of larval lethality, the precise role of INS-31 in C. elegans development is not yet clear as INS-31/19 overexpression does not enhance dauer arrest in either a wild-type or daf-2 mutant background, and loss of INS-31 function does not result in a mutant phenotype. T10D4.5 T10D4.5 Member of the 7-transmembrane chemoreceptor family of G-protein coupled receptors (GPCR), has high similarity to uncharacterized C. elegans ZC204.5 7TM chemoreceptor, srh family T10D4.6 T10D4.6 Protein of unknown function, has similarity in the C-terminus to C. elegans F28H6.6 T10D4.7 T10D4.7 Protein containing a DUF130 domain of unknown function, has moderate similarity to uncharacterized C. elegans R03H10.5 T10D4.8 T10D4.8 Member of the 7-transmembrane chemoreceptor family of G-protein coupled receptors (GPCR), has high similarity to uncharacterized C. elegans F22E5.15 7TM chemoreceptor, sri family T10D4.9 T10D4.9 Member of the 7-transmembrane chemoreceptor family of G-protein coupled receptors (GPCR), has high similarity to uncharacterized C. elegans T10D4.10 7TM chemoreceptor, sri family T10E10.3 srq-7;T10E10.3 G protein-coupled receptor of unknown function, no homolog found in human or D. melanogaster G-protein receptor T10E9.1 T10E9.1 Protein containing an F-box domain, which serve as a link between a target protein and a ubiquitin-conjugating enzyme This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins. T10E9.2 T10E9.2 Protein of unknown function T10E9.3 T10E9.3 Protein of unknown function T10E9.4 T10E9.4 Protein containing a DX module domain T10E9.5 T10E9.5 Protein of unknown function T10E9.6 T10E9.6 Member of the TB2 or DP1 and HVA22 related protein family T10E9.7 T10E9.7 Member of the respiratory-chain NADH dehydrogenase 30 Kd subunit family, contains a KH domain, which may bind RNA NADH-ubiquinone oxidoredutase 30 kd subunit; This gene encodes a protein predicted by Eisenberg and coworkers, with 68% accuracy, to be mitochondrial. T10E9.8 T10E9.8 Protein of unknown function T10E9.9 T10E9.9 Putative acyl-CoA dehydrogenase, has strong similarity to human short chain acyl-CoA dehydrogenases ACADSB and ACADS acyl-CoA dehydrongenase T10F2.1 T10F2.1 Protein with high similarity to glycyl-tRNA synthetase (human GARS), which is associated with dermatomyositis, contains a tRNA synthetase class II core domain (G, H, P, S and T), an anticodon binding domain and a WHEP-TRS domain Glycyl-tRNA synthetase; grs-1 encodes a member of the glycyl-tRNA synthetase family that affects embryonic viability and spindle maintenance during anaphase. T10F2.2 T10F2.2 Protein with high similarity to solute carrier family 25 member 15 (mitochondrial ornithine transporter 1, human SLC25A15), which functions in ornithine metabolism and is implicated in hyperornithinemia-hyperammonemia-homocitrullinuria (HHH) syndrome Mitochondrial carrier protein; T10F2.2 is orthologous to the human gene SOLUTE CARRIER FAMILY 25 (MITOCHONDRIAL CARRIER; ORNITHINE TRANSPORTER) MEMBER 15 (SLC25A15; OMIM:603861), which when mutated leads to disease. T10F2.3 T10F2.3 Protein with weak similarity to ubiquitin-specific proteases, has similarity to S. cerevisiae Ulp1p and Smt4p T10F2.4 T10F2.4 Protein containing six WD domains (WD-40 repeat), which may mediate protein-protein interactions, has low similarity to S. cerevisiae Prp19p, which is a non-snRNP spliceosome component involved in mitotic recombination and gene conversion T10G3.1 T10G3.1 Protein of unknown function T10G3.2 T10G3.2 Protein of unknown function, has weak similarity to C. elegans T10G3.4 T10G3.3 T10G3.3 Protein of unknown function, has weak similarity to C. elegans ZC412.4 T10G3.4 T10G3.4 Member of the C. elegans Sre G protein-coupled chemoreceptor family, which are putative chemosensory receptors, has low similarity to uncharacterized C. elegans T10G3.2 7TM receptor-like T10G3.5 eea1;T10G3.5 Putative coiled-coil protein, has similarity to human EEA1, an early endosome associated protein endosomal protein P162 like T10G3.6 T10G3.6 Protein with strong similarity to U6 snRNA-associated Sm-like protein (human LSM2), which is a heteromeric complex subunit that binds to the 3' end of U6 small nuclear RNA, member of the Sm family, which are core constituents of snRNP complexes Yeast hypothetical 11.2 KD protein like; gut-2 encodes a member of the Sm protein family with highest similarity to human U6 snRNA-associated Sm-like protein, LSm2, that affects embryonic viability. T10H10.1 hum-6;T10H10.1 Myosin I, class VII unconventional myosin heavy chain myosin; hum-6 is orthologous to the human gene MYOSIN VIIA (MYO7A; OMIM:276903), which when mutated leads to Usher syndrome type IB. T10H10.2 T10H10.2 Member of the thioredoxin family, which are small enzymes involved in redox reactions, has low similarity to quiescin Q6 (FAD-dependent sulfhydryl oxidase, rat Qscn6), which is a secreted enzyme expressed primarily in the male reproductive tract T10H10.3 T10H10.3 Protein containing two WW domains, which bind proline-rich peptide epitopes T10H4.10 T10H4.10 Member of the cytochrome P450 family, has low similarity to cytochrome P450 subfamily 2F polypeptide 1 (mouse Cyp2f2), which is a monooxygenase that catalyzes hydroxylation of naphthalene cytochrome P450 T10H4.11 T10H4.11 Member of the cytochrome P450 family, has low similarity to cytochrome P450 subfamily 2C polypeptide 8 (mephenytoin 4-hydroxylase, human CYP2C8), which is a heme-binding monooxygenase that metabolizes steroids, fatty acids, and xenobiotics cytochrome P450 T10H4.12 cpr-3;T10H4.12 Member of the Cathepsin B-like cysteine protease family cathepsin protease T10H4.2 T10H4.2 Member of the 7-transmembrane chemoreceptor family of G-protein coupled receptors (GPCR), has low similarity to C. elegans ODR-10, which is involved in odorant response 7TM receptor T10H4.3 T10H4.3 G protein-coupled receptor of unknown function, no homolog found in human or D. melanogaster 7TM chemoreceptor, srw family T10H4.4 T10H4.4 Protein of unknown function, has strong similarity over the C-terminus to C. elegans M01B2.10 T10H4.5 T10H4.5 G protein-coupled receptor of unknown function, no homolog found in human or D. melanogaster 7TM chemoreceptor, srw family T10H4.6 T10H4.6 G protein-coupled receptor of unknown function, no homolog found in human or D. melanogaster 7TM chemoreceptor, srw family T10H4.7 T10H4.7 G protein-coupled receptor of unknown function, no homolog found in human or D. melanogaster T10H4.8 T10H4.8 Putative ortholog of C. elegans T10H4.6 gene product 7TM chemoreceptor, srw family T10H4.9 T10H4.9 Member of the rhodopsin family of G-protein coupled receptors (GPCR), has high similarity to uncharacterized C. elegans Y43B11AL.2 7 transmembrane receptor (rhodopsin family) T10H9.1 T10H9.1 G protein-coupled receptor with similarity to members of the SRE subfamily, no homolog found in human or D. melanogaster T10H9.2 T10H9.2 Protein containing a protein kinase domain, has low similarity to a region of anaplastic lymphoma kinase (human ALK), which is a tyrosine kinase that may be involved in brain development and be associated with anaplastic large cell non-Hodgkin's lymphomas protein kinase T10H9.3 T10H9.3 Protein with weak similarity to syntaxin 18 (human STX18), which functions in transport between the endoplasmic reticulum and Golgi and causes endoplasmic reticulum aggregation when overexpressed T10H9.4 snb-1;T10H9.4 Synaptic-vesicle membrane protein, synaptobrevin synaptobrevin; The snb-1 gene encodes synaptobrevin, a synaptic vesicle protein orthologous to human vesicle-associated membrane protein 1 (VAMP1 OMIM:185880) and 2 (VAMP2 OMIM:185881), and is required for viability and synaptic transmission; SNB-1 is likely to play a role in vesicle docking and/or fusion and is expressed in neurons where it colocalizes with synaptic vesicle proteins RAB-3 and synaptotagmin. T10H9.5 T10H9.5 Member of the ABC transporter family, which are involved in membrane translocation of a variety of compounds, contains an ABC transporter transmembrane domain, has low similarity to ATP-binding cassette subfamily D (ALD) member 3 (rat Abcd3) ABC transporter T10H9.6 T10H9.6 Member of the 7-transmembrane chemoreceptor family of G-protein coupled receptors (GPCR), has low similarity to C. elegans ODR-10, which is involved in odorant response 7TM chemoreceptor, str family T11A5.1 T11A5.1 Protein containing an AT-hook motif, which bind DNA with a preference for A-T rich regions, and a ubiquitin interaction motif T11A5.2 T11A5.2 Protein of unknown function, has high similarity to uncharacterized C. elegans T11A5.3 T11A5.3 T11A5.3 Protein of unknown function, has high similarity to uncharacterized C. elegans T11A5.2 T11A5.4 T11A5.4 Putative ortholog of C. elegans T11A5.3 gene product T11A5.5 T11A5.5 Protein of unknown function, has moderate similarity to uncharacterized C. elegans AH10.2 T11A5.6 sol;T11A5.6 Member of the calpain family of cysteine proteases, has a region of low similarity to a region of calpain I (rat Capn1), which is a catalytic subunit of the calcium-dependent cysteine (thiol) protease mu-calpain calpain T11B7.1 T11B7.1 Putative coiled-coil protein, has weak similarity to myosins T11B7.2 T11B7.2 Protein of unknown function T11B7.3 T11B7.3 Protein containing two collagen triple helix repeats and one nematode cuticle collagen N-terminal domain, has moderate similarity to a region of C. elegans BLI-1, which is a putative collagen involved in embryogenesis and morphogenesis and chemotaxis cuticle collagen T11B7.4 T11B7.4 Protein containing eight LIM domains, which may mediate protein-protein interactions, and a PDZ, DHR, or GLGF domain, which are found in signaling proteins, has a region of high similarity to a region of LIM domain binding 3 (human LDB3) LIM domains; eat-1 encodes both a homolog of mammalian alpha-actinin associated LIM protein (ALP) and a homolog of mammalian Enigma protein, through alternative splicing; eat-1 is homologous to a mouse gene (Alp) causing right ventricular cardiomyopathy when mutated; EAT-1a/b proteins are collectively required for normal life span determination, feeding (pharyngeal pumping), locomotion, integrity of muscle cell-cell attachments, and body shape; the Enigma proteins are localised to all muscle types and more specifically to dense bodies and sites of cell-cell contact in body wall muscle; while ALP localises to body wall muscle dense bodies, it is different from the Enigma proteins in that, it also localises to muscle cell nuclei and is absent from sites of muscle cell-cell adhesion. T11B7.5 T11B7.5 Protein of unknown function T11F1.1 T11F1.1 Protein of unknown function, has moderate similarity to uncharacterized C. elegans H25K10.7 7TM chemoreceptor, srw family T11F1.2 T11F1.2 Member of an uncharacterized protein family T11F1.3 T11F1.3 Protein of unknown function T11F1.5 T11F1.5 Protein of unknown function, has weak similarity to C. elegans F18E3.9 7TM chemoreceptor, srw family T11F1.6 T11F1.6 Member of an uncharacterized protein family T11F1.7 T11F1.7 Protein of unknown function, has strong similarity to N-terminal region of C. elegans T11F1.8 T11F1.8 T11F1.8 Protein containing two DUF41 domains of unknown function, has low similarity to uncharacterized C. elegans K12D9.12 T11F8.1 T11F8.1 Protein of unknown function, has high similarity to uncharacterized C. elegans C24D10.5 T11F8.2 T11F8.2 Putative ortholog of C. elegans T11F8.1 gene product T11F8.3 rme-2;lr;T11F8.3 Vitellogenin receptor LDL-like receptor T11F8.4 T11F8.4 Protein containing two protein kinase domains, has weak similarity to S. cerevisiae Yck1p, which is a casein kinase I isoform involved in protein amino acid phosphorylation protein kinase T11F9.1 T11F9.1 Protein of unknown function, has moderate similarity to uncharacterized C. elegans F32D8.10 G-protein coupled receptor T11F9.10 T11F9.10 Protein of unknown function, putative paralog of C. elegans F40D4.13 T11F9.11 T11F9.11 Member of the short-chain dehydrogenase-reductase family, which are NAD- or NADP-dependent oxidoreductases, has moderate similarity to short-chain dehydrogenase-reductase 1 (human SDR1), which reduces all-trans-retinal to retinol 3-OXOACYL-[ACYL-CARRIER PROTEIN] REDUCTASE; dhs-19 encodes a short-chain dehydrogenase predicted to be mitochondrial. T11F9.12 T11F9.12 Protein of unknown function T11F9.13 T11F9.13 Protein of unknown function, has strong similarity to C. elegans F41C6.2 T11F9.14 T11F9.14 Protein of unknown function, has strong similarity to uncharacterized C. elegans C53B7.6 T11F9.2 T11F9.2 Member of the ZIP zinc transporter family, which may be metal transporters Human mRNA (KIAA0062) like T11F9.3 T11F9.3 Member of the astacin (M12A) family of metalloproteases, has low similarity to a region of C. elegans HCH-1, which is a putative zinc-dependent metalloprotease involved in cell migration and neurogenesis zinc metalloprotease T11F9.4 T11F9.4 Member of the amino acid permease family, has strong similarity to human cationic amino acid transporters, has moderate similarity to yeast methionine transporters amino acid permease like T11F9.5 T11F9.5 Member of the astacin (M12A) family of metalloproteases, has low similarity to a region of C. elegans HCH-1, which is a putative zinc-dependent metalloprotease involved in cell migration and neurogenesis zinc metalloprotease T11F9.6 T11F9.6 Putative zinc metalloprotease zinc metalloprotease T11F9.7 T11F9.7 Protein of unknown function, has strong similarity to C. elegans F23C8.B T11F9.8 T11F9.8 Member of the zinc metalloprotease protein family zinc metalloprotease T11F9.9 T11F9.9 Protein with high similarity to C. elegans DPY-16, which is a collagen that is inovlved in morphogenesis of epithelium, contains two collagen triple helix repeats and one nematode cuticle collagen N-terminal domain collagen T11G6.1 T11G6.1 Putative histidyl-tRNA synthetase histidyl-tRNA synthetase (mitochondrial); hrs-1 encodes predicted cytoplasmic and mitochondrial histidyl-tRNA synthetases (HisRS), class II aminoacyl-tRNA synthetases that catalyze the attachment of histidine to its cognate tRNAs and are thus required for protein biosynthesis; HRS-1 synthetases are required for embryogenesis, germline development, wild type body morphology, and normal rates of postembryonic growth. T11G6.2 T11G6.2 Member of the sugar (and other) transporter family, has weak similarity to glucose-6-phosphate translocase (human G6PT1), which is involved in glycogen metabolism and is associated with glycogen storage disease type Ib, Ic, and Id bacterial regulatory protein UHPC like; This gene encodes a protein predicted by Eisenberg and coworkers, with 52% accuracy, to be mitochondrial. T11G6.3 T11G6.3 Member of the sugar (and other) transporter family, has weak similarity to glucose-6-phosphate translocase (human G6PT1), which involved in glycogen metabolism and is associated with glycogen storage disease type Ib, Ic, and Id bacterial regulatory protein UHPC like; This gene encodes a protein predicted by Eisenberg and coworkers, with 52% accuracy, to be mitochondrial. T11G6.4 T11G6.4 Putative ortholog of C. elegans T11G6.3 gene product bacterial regulatory protein UHPC like; This gene encodes a protein predicted by Eisenberg and coworkers, with 52% accuracy, to be mitochondrial. T11G6.5 T11G6.5 Protein with strong similarity to C. elegans Y73B3A.9 gene product T11G6.7 T11G6.7 Protein of unknown function T11G6.8 PX1;T11G6.8 Protein containing a phox protein (PX) domain, a CCCH-type zinc finger domain, and an RNA recognition motif (RRM, RBD, or RNP), has a region of low similarity to a region of S. cerevisiae Ecm2p, which is a pre-mRNA splicing factor RNA recognition motif. (aka RRM, RBD, or RNP domain) T12A2.1 T12A2.1 Member of chlorohydrolase family, which catalyze hydrolytic dechlorination T12A2.10 srg-9;T12A2.10 G protein-coupled receptor, probably involved in chemosensation by sensory amphid neurons, no homolog found in human or D. melanogaster 7TM chemoreceptor, srg family T12A2.11 srg-5;T12A2.11 G protein-coupled receptor, probably involved in chemosensation by sensory amphid neurons, no homolog found in human or D. melanogaster 7TM chemoreceptor, srg family T12A2.12 srg-4;T12A2.12 G protein-coupled receptor, probably involved in chemosensation by sensory amphid neurons, no homolog found in human or D. melanogaster 7TM chemoreceptor, srg family T12A2.13 srg-6;T12A2.13 G protein-coupled receptor, probably involved in chemosensation by sensory amphid neurons, no homolog found in human or D. melanogaster 7TM chemoreceptor, srg family T12A2.14 T12A2.14 Protein containing a C2 domain, which may be involved in calcium-dependent phospholipid binding T12A2.15 T12A2.15 Protein containing two C2 domains, which may be involved in calcium-dependent phospholipid binding T12A2.2 T12A2.2 Putative subunit of oligosaccharyltransferase T12A2.3 T12A2.3 Protein of unknown function T12A2.5 T12A2.5 Putative ortholog of C. elegans T12A2.6 gene product T12A2.6 T12A2.6 Putative ortholog of C. elegans T12A2.5 gene product T12A2.7 T12A2.7 Protein of unknown function, has moderate similarity to uncharacterized human BCAS2 T12A2.8 T12A2.8 Protein containing a Xeroderma pigmentosum group G (XPG) N-terminal domain and an XPG I-region (Xeroderma pigmentosum group G internal region) domain, which function in DNA excision repair, has a region of low similarity to a region of S. cerevisiae Rad2p DNA repair protein T12A2.9 srg-8;T12A2.9 G protein-coupled receptor, probably involved in chemosensation by sensory amphid neurons, no homolog found in human or D. melanogaster 7TM chemoreceptor, srg family T12A7.1 T12A7.1 Protein containing a C2 domain, which may be involved in calcium-dependent phospholipid binding, has moderate similarity to copine III (human CPNE3), which displays protein kinase activity and may play a role in membrane trafficking C2 domain (2 domains); gem-4 encodes a Ca[2+]-dependent phosphatidylserine binding protein (copine) that antagonizes GON-2 in gonadal cell division, with no other obvious function in normal animals; GEM-4 is highly similar to three human proteins, copine I, copine III, and KIA1599 (40% identity over 590 residues); GEM-4 is also similar to its C. elegans paralog, F26D10.4 (73% identity over 637 residues), with at least three other copines being encoded by the C. elegans genome; since both GEM-4 and GON-2 are predicted to be plasma membrane proteins, they may interact directly. T12A7.2 T12A7.2 Protein of unknown function, has a region of low similarity to a region of C. elegans CED-1, which is a putative cell surface phagocytic receptor that recognizes cell corpses in apoptosis T12A7.3 T12A7.3 Member of the SCP-like extracellular protein family, has moderate similarity to uncharacterized C. elegans F49E11.10 testis-specific protein TPX1 like T12A7.4 T12A7.4 Member of the class 2 lipase family, has high similarity to uncharacterized C. elegans T01C3.4 lipase T12A7.5 T12A7.5 Protein of unknown function T12A7.6 T12A7.6 Protein of unknown function T12A7.7 T12A7.7 Putative ortholog of C. elegans W05H5.4 gene product T12B3.1 T12B3.D;T12B3.1 Protein with similarity across the middle region to tyrosine protein phosphatases, has weak similarity to human cyclin-dependent kinase inhibitor CDKN3 phosphatase T12B3.3 T12B3.B;T12B3.3 Member of the glycerophosphoryl diester phosphodiesterase family, which are involved in lipid metabolism, has low similarity to membrane interacting protein of RGS16 (rat Mir16), which associates with Rgs16 and Rgs2 phosphodiesterase T12B5.1 T12B5.1 Protein containing a DUF38 domain of unknown function and an F-box domain, which serve as a link between a target protein and a ubiquitin-conjugating enzyme, has high similarity to uncharacterized C. elegans T12B5.8 This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins; this gene's encoded protein also contains an FTH/DUF38 motif, which may also mediate protein-protein interaction. T12B5.10 T12B5.10 Protein containing a DUF38 domain of unknown function and an F-box domain, which serve as a link between a target protein and a ubiquitin-conjugating enzyme, has low similarity to C. elegans FOG-2, which is required for the sexual identity of germ cells This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins; this gene's encoded protein also contains an FTH/DUF38 motif, which may also mediate protein-protein interaction. T12B5.11 T12B5.11 Protein containing a DUF38 domain of unknown function and an F-box domain, which serve as a link between a target protein and a ubiquitin-conjugating enzyme, has low similarity to C. elegans FOG-2, which is required for the sexual identity of germ cells This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins; this gene's encoded protein also contains an FTH/DUF38 motif, which may also mediate protein-protein interaction. T12B5.12 T12B5.12 Protein containing a DUF38 domain of unknown function and an F-box domain, which serve as a link between a target protein and a ubiquitin-conjugating enzyme, has low similarity to C. elegans FOG-2, which is required for the sexual identity of germ cells This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins; this gene's encoded protein also contains an FTH/DUF38 motif, which may also mediate protein-protein interaction. T12B5.13 T12B5.13 Member of an uncharacterized protein family T12B5.2 T12B5.2 Protein containing a DUF38 domain of unknown function and an F-box domain, which serve as a link between a target protein and a ubiquitin-conjugating enzyme, has low similarity to C. elegans FOG-2, which is required for the sexual identity of germ cells This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins; this gene's encoded protein also contains an FTH/DUF38 motif, which may also mediate protein-protein interaction. T12B5.3 T12B5.3 Protein containing a DUF38 domain of unknown function and an F-box domain, which serve as a link between a target protein and a ubiquitin-conjugating enzyme, has low similarity to C. elegans FOG-2, which is required for the sexual identity of germ cells This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins; this gene's encoded protein also contains an FTH/DUF38 motif, which may also mediate protein-protein interaction. T12B5.4 T12B5.4 Protein containing a DUF38 domain of unknown function and an F-box domain, which serve as a link between a target protein and a ubiquitin-conjugating enzyme, has low similarity to C. elegans FOG-2, which is required for the sexual identity of germ cells This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins; this gene's encoded protein also contains an FTH/DUF38 motif, which may also mediate protein-protein interaction. T12B5.5 T12B5.5 Member of an uncharacterized protein family T12B5.6 T12B5.6 Member of the transposase family, which are required for excising and inserting mobile genetic elements, contains an F-box domain, which serve as a link between a target protein and a ubiquitin-conjugating enzyme, and a DUF38 domain of unknown function transposase; This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins; this gene's encoded protein also contains an FTH/DUF38 motif, which may also mediate protein-protein interaction. T12B5.7 T12B5.7 Member of an uncharacterized protein family T12B5.8 T12B5.8 Member of an uncharacterized protein family This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins; this gene's encoded protein also contains an FTH/DUF38 motif, which may also mediate protein-protein interaction. T12C9.1 nhr-16;T12C9.1;nhr-G Member of the nuclear hormone receptor/Zinc finger protein family zinc finger DNA-binding protein T12C9.2 T12C9.2 Protein of unknown function T12C9.5 T12C9.5 Protein containing a nuclear hormone receptor ligand-binding domain and a nuclear hormone receptor C4-type zinc finger domain, which bind DNA and may be involved in regulation of transcription, has weak similarity to C. elegans NHR-80 T12C9.6 T12C9.6 Putative ortholog of C. elegans nhr-16 gene product T12C9.7 T12C9.7 Putative ortholog of C. elegans T12C9.4 gene product T12D8.1 T12D8.1 Protein containing four PHD-fingers, which may be involved in transcriptional regulation, and a SET domain, which are involved in protein-protein interactions, has a region of low similarity to a region of myeloid-lymphoid leukemia (human MLL) PHD-finger. (2 domains), SET domain T12D8.2 T12D8.2 Protein containing an RNA recognition motif (RRM, RBD, or RNP) RNA recognition motif. (aka RRM, RBD, or RNP domain) T12D8.3 T12D8.3 Protein containing two ankyrin (Ank) repeats, which may mediate protein-protein interactions, a BolA-like protein domain, which may be involved in controlling cell morphology, and an acyl CoA binding domain Ank repeat T12D8.4 T12D8.4 Protein with weak similarity to vitamin D-3 upregulated protein-1 (mouse Txnip), which is thioredoxin binding protein induced by oxidative stress that functions as an oxidative stress mediator by inhibiting thioredoxin activity T12D8.5 T12D8.5 Protein of unknown function T12D8.6 T12D8.6 Member of an uncharacterized protein family EF hand T12D8.7 taf-10;T12D8.7 Putative component of RNA polymerase II pre-initiation complex, important for embryonic transcription T12D8.8 T12D8.8 Protein with high similarity to suppression of tumorigenicity 13 (Hsp70-interacting protein, human ST13), which is a cochaperone that acts in protein complex assembly, heat shock response, and lysosomal transport and is downregulated in colorectal cancer TPR Domain (2 domains) T12D8.9 T12D8.9 Protein of unknown function, has weak similarity to C. elegans C56G2.2 T12E12.1 T12E12.1 Protein with a TRIAD composite zinc finger domain, has strong similarity to human TRIAD1 type I (Hs.9899) and D. melanogaster ARI2 (ariadne 2) proteins T12E12.2 T12E12.2 Protein containing a Chromo domain, which bind chromatin T12E12.3 T12E12.3 Protein of unknown function, has high similarity to uncharacterized C. elegans R06A4.2 T12E12.4 drp-1;T12E12.4 Member of the dynamin-related GTPase protein family, this protein acts either as a regulator of mitochondrial outer membrane scission or is actively involved in the severing process dynamin-like protein; drp-1 encodes a dynamin-related protein, orthologous to Dnm1p in S. cerevisiae and DRP1 in mammals, that is required for severing of the mitochondrial outer membrane during mitochondrial division. T12E12.5 T12E12.5 Protein of unknown function T12E12.6 T12E12.6 Member of the M1 peptidase family of aminopeptidases, has low similarity to region of aminopeptidase N (aminopeptidase M, human ANPEP), which is a zinc metallopeptidase that degrades regulatory peptides and is involved in extracellular matrix degradation zinc metalloprotease T12F5.1 T12F5.1 Protein of unknown function T12F5.2 T12F5.2 Putative paralog of C. elegans T08D2.C gene product T12F5.3 glh-4;T12F5.3 Member of the RNA helicase, DEAD-box protein family that is a component of P-granules helicase; glh-4 encodes a putative germline RNA helicase that affects germline proliferation, oogenesis, spermatogenesis, and hence fertility in combination with glh-1, and is partially redundant with glh-1; glh-4 is a constituent of P granules and expression is most abundant in newly fertilized embryos. T12F5.4 lin-59;T12F5.4 Trithorax-related protein functioning in hindgut development T12F5.5 T12F5.5 Protein with moderate similarity to C. elegans R144.7 gene product The protein product of this gene is predicted to contain a glutamine/asparagine (Q/N)-rich ('prion') domain, by the algorithm of Michelitsch and Weissman (as of the WS77 release of WormBase, i.e., in wormpep77). T12G3.1 T12G3.1 Protein containing a ZZ zinc finger Drosphila REF (2)P like T12G3.2 T12G3.2 Protein of unknown function, has moderate similarity to uncharacterized C. elegans C27D8.3 The T12G3.2 gene encodes a protein that may be involved in apoptosis. T12G3.4 T12G3.4 Member of the strictosidine synthase family, which catalyze the condensation of tryptamine with secologanin to form strictosidine, has low similarity to uncharacterized human C20ORF3 strictosidine synthase like T12G3.5 T12G3.5 Possible mitochondrial large ribosomal subunit protein T12G3.6 T12G3.6 Protein of unknown function T12G3.7 T12G3.7 Protein of unknown function T13A10.1 T13A10.1 Protein of unknown function, has high similarity to uncharacterized C. elegans F36H12.5 T13A10.10 T13A10.10 Member of the amino acid permease family (major facilitator superfamily), has strong similarity to human cationic amino acid transporters, has moderate similarity to yeast methionine transporters amino acid permease T13A10.11 T13A10.11 Protein with high similarity to C. elegans C49F5.1, contains two S-adenosylmethionine synthetase N-terminal domains, one S-adenosylmethionine synthetase C-terminal domain, and one S-adenosylmethionine synthetase central domain S-adenosylmethionine synthetase T13A10.12 T13A10.12 Protein of unknown function, has high similarity to uncharacterized C. elegans T13A10.13 7TM chemoreceptor, srv family T13A10.13 T13A10.13 Protein of unknown function, has high similarity to uncharacterized C. elegans T13A10.12 7TM chemoreceptor, srv family T13A10.2 T13A10.2 Protein containing a C3HC4 type (RING) zinc finger, has very strong similarity to uncharacterized C. elegans F19G12.1 T13A10.4 T13A10.4 Protein of unknown function T13A10.5 T13A10.5 Protein with moderate similarity to C. elegans Y39B6A.1 gene product nlp-16 encodes a predicted neuropeptide that does not belong to a multigene family in C. elegans and is not clearly related to well-characterized neuropeptides; the peptide encoded by nlp-16 has been isolated from Ascaris suum. T13A10.6 T13A10.6 Protein of unknown function, has high similarity to uncharacterized C. elegans T13A10.13 7TM chemoreceptor, srv family T13A10.7 T13A10.7 Protein of unknown function, has high similarity to uncharacterized C. elegans Y73B6BL.10 7TM chemoreceptor, srv family T13A10.8 T13A10.8 Protein with strong similarity to C. elegans T13A10.7 gene product T13A10.9 T13A10.9 Putative ortholog of C. elegans T13A10.7 gene product 7TM chemoreceptor, srv family T13B5.1 T13B5.1 Member of the sodium:neurotransmitter symporter family, has moderate similarity to betaine:gamma-aminobutyric acid transporter 1 (human SLC6A12), which is a symporter that mediates the sodium and chloride dependent transport of gamma-aminobutyric acid sodium/chloride-dependent GABA transporter T13B5.3 T13B5.3 Member of the histidine acid phosphatase family, which hydrolyze phosphate esters at low pH, has low similarity to lysosomal acid phosphatase (rat Acp2), which is a tartrate-inhibitable lysosomal enzyme acid phosphatase T13B5.4 T13B5.4 Protein containing two collagen triple helix repeats and one nematode cuticle collagen N-terminal domain, has a region of moderate similarity to a region of collagen type V alpha 2 subunit (human COL5A2), which functions in connective tissue maintenance cuticular collagen; col-40 encodes a cuticle collagen protein that belongs to the col-6 cuticle collagen family; col-40 transcript is present in L1 larvae and at the L2d-dauer molt. T13B5.5 T13B5.5 Member of the class 2 lipase family, has high similarity to uncharacterized C. elegans T13B5.6 T13B5.6 T13B5.6 Member of the class 2 lipase family, has high similarity to uncharacterized C. elegans T13B5.5 T13B5.7 T13B5.7 Member of the class 2 lipase family, has high similarity to uncharacterized C. elegans T13B5.5 T13B5.8 T13B5.8 Protein of unknown function, has weak similarity to C. elegans W02F12.6 T13B5.9 T13B5.9 Protein of unknown function T13C2.1 T13C2.1 Tc5 transposase T13C2.2 T13C2.2 Protein of unknown function T13C2.3 T13C2.3 Protein of unknown function T13C2.6 T13C2.6 Putative ortholog of C. elegans lrp-1 gene product T13C5.1 daf-9;T13C5.1 Cytochrome P450 involved in cholesterol-dependent synthesis of a steroid that promotes larval growth and reproductive development cytochrome P450; daf-9 encodes a cytochrome P450 of the CYP2 subfamily that by homology is predicted to function as a steroidogenic or fatty acid hydroxylase; DAF-9 likely functions cell nonautonomously in hypodermal and neuronal cells to produce, for the DAF-12 nuclear receptor, a lipophilic hormone whose presence is necessary for bypassing entry into the alternative L3/dauer larval stage and promoting reproductive development; in regulating dauer formation, daf-9 acts downstream of the DAF-2/insulin/IGF receptor and the DAF-7/TGFbeta ligand, suggesting that at least two of the signaling pathways that control dauer formation converge, in part, upon daf-9; in addition, daf-9 activity is required for gonadal cell migration; a DAF-9::GFP fusion is expressed in the XXXL/R head cells at all developmental stages, in hypodermal cells from the L2 to L4 larval stages, and in the spermatheca of adult hermaphrodites. T13C5.2 T13C5.2 Protein of unknown function, has strong similarity to C. elegans T13C5.3 T13C5.3 T13C5.3 Protein of unknown function, has strong similarity to C. elegans T13C5.2 T13C5.4 T13C5.4 Protein containing a homeobox domain (homeodomain), which are found in transcription factors, has a region of moderate similarity to a region of cone-rod homeobox protein (rat Crx), which is a transcription factor regulating pineal gland gene expression homeobox protein; T13C5.4 encodes a paired-like homeodomain protein of the Q50 class, which has no obvious function in mass RNAi assays. T13C5.5 T13C5.5 Member of the carbonic anhydrase family, which catalyze the reversible hydration of carbon dioxide, has moderate similarity to uncharacterized C. elegans Y116A8C.28 carbonic anhydrase; bca-1 encodes a member of the carbonic anhydrase family. T13C5.6 T13C5.6 Member of the phosphatidic acid phosphatase-related (PAP2) phosphoesterase family T13F2.1 fat-4;des-5;T13F2.1 Delta5-fatty acid desaturase; has strong similarity to H. sapiens Hs.132898 gene product cytochrome B5 containing fusion protein; fat-4 encodes a delta-5 fatty acid desaturase; when expressed heterologously in S. cerevisiae, FAT-4 converts di-homo-gamma-linolenic acid (20:3delta8,11,14) to arachidonic acid (20:4delta5,8,11,14), an important precursor in eicosanoid metabolism, as well as on other fatty acids (C18 to C20); FAT-4 is is required in vivo for delta-5 unsaturated fatty acid synthesis. T13F2.10 T13F2.10 Sperm-specific protein involved in sperm motility, member of the major sperm protein (MSP) family major sperm protein; msp-79 encodes a member of the major sperm protein family. T13F2.11 msp-78;T13F2.11 Sperm-specific protein involved in sperm motility, member of the major sperm protein (MSP) family major sperm protein; msp-78 encodes a protein that belongs to a family of proteins called the Major Sperm Proteins (MSPs) that is conserved in nematodes; this family consists of closely related, small, basic proteins that make up 15% of sperm protein; this multigene family consists of over fifty genes, including many pseudogenes; MSPs are involved in both extracellular signaling and cytoskeletal functions during reproduction-MSP antagonizes Eph/ephrin signaling, in part, by binding VAB-1 Eph receptor tyrosine kinase on oocytes and sheath cells to promote oocyte maturation and MAPK activation; MSPs assemble into fibrous networks that drive movement of the C. elegans sperm; msp genes are expressed only in late primary spermatocytes. T13F2.12 T13F2.12 Protein containing a major sperm protein (MSP) domain, which are involved in sperm motility, has very strong similarity to uncharacterized C. elegans F32B6.7 T13F2.2 T13F2.2 Member of the transcriptional coactivator p15 (PC4) family, which mediate activation by several distinct factors, has moderate similarity to RNA polymerase II transcriptional coactivator PC4 (human PC4), which is a transcriptional coactivator or repressor single-stranded DNA binding protein P9 T13F2.3 T13F2.3 Protein containing eight BRCA1 (breast cancer type 1) C terminus (BRCT) domains, which are found in some cell cycle checkpoint proteins human KIAA0170 protein-like; pis-1 encodes an ortholog of mammalian Pax transcription activation domain interacting protein PTIP; PIS-1 has an N-terminal glutamine/asparagine-rich domain and four C-terminal BRCT domains, and is dispensable for obvious functions in mass RNAi assays; mammalian PTIP binds to the activation domain of Pax2 and other Pax proteins, and colocalizes with Pax2 to actively expressed chromatin, and appears to be required for embryonic mitosis (perhaps because of a link between BRCT domains and DNA repair). T13F2.4 T13F2.4 Protein of unknown function T13F2.5 T13F2.5 Member of the C. elegans Sre G protein-coupled chemoreceptor family, which are putative chemosensory receptors 7TM receptor, sre family T13F2.6 T13F2.6 Protein of unknown function T13F2.7 T13F2.7 Protein of unknown function T13F2.8 cav-1;T13F2.8 Member of the caveolin protein family caveolin; cav-1 encodes a member of the caveolin protein family that affects viability and Ras/MAP-kinase-dependent progression through the meiotic cell cycle meiotic; expressed in the adult germ line and during embryonic development. T13F2.9 T13F2.9 Member of a protein family T13F3.1 T13F3.1 Member of the 7-transmembrane chemoreceptor family of G-protein coupled receptors (GPCR), has low similarity to C. elegans ODR-10, which is involved in odorant response 7TM receptor T13F3.2 T13F3.2 Protein containing a nuclear hormone receptor C4-type zinc finger domain, has weak similarity to C. elegans NHR-58, which is a putative transcription regulator involved in embryogenesis and morphogenesis Zinc finger, C4 type (two domains) T13F3.3 T13F3.3 Protein containing a nuclear hormone receptor C4-type zinc finger domain, which bind DNA and may be involved in regulation of transcription, has low similarity to C. elegans NHR-58, which is involved in embryogenesis and morphogenesis Zinc finger, C4 type (two domains); nhr-127 encodes a member of the nuclear hormone receptor family; expressed in hypodermal seam cells from the embryonic 1.5-fold stage until the L1 larval stage. T13F3.4 T13F3.4 Protein of unknown function, has moderate similarity to C. elegans C03G6.5 T13F3.5 T13F3.5 Protein containing a DUF38 domain of unknown function and an F-box domain, which serve as a link between a target protein and a ubiquitin-conjugating enzyme, has a region of low similarity to C. elegans FOG-2 F-box domain.; This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins; this gene's encoded protein also contains an FTH/DUF38 motif, which may also mediate protein-protein interaction. T13F3.6 T13F3.6 Putative ortholog of C. elegans T13F3.5 gene product T13G4.1 T13G4.1 Protein with strong similarity to C. elegans K11H3.4 gene product T13G4.2 T13G4.2 Protein of unknown function T13G4.3 T13G4.3 Putative ortholog of C. elegans B0416.1 gene product T13G4.4 T13G4.4 Protein of unknown function T13G4.5 T13G4.5 Protein with weak similarity to C. elegans W08F4.10 gene product T13G4.6 T13G4.6 Protein of unknwon function T13G4.7 T13G4.7 Protein of unknown function T13H10.1 kin-5;T13H10.1 Protein containing a protein kinase domain and a Src homology 2 (SH2) domain, which are regulatory modules of intracellular signaling, has low similarity to fyn proto-oncogene (rat Fyn), which is cell surface receptor-linked signal transduction mediator Src homology domain 2, tyrosine-protein kinase (FES/FPS subfamily); kin-5 encodes a predicted protein tyrosine kinase that is most closely related to the non-receptor tyrosine kinases Fes/Fps and Fer that contain an SH2 domain and a tyrosine kinase domain (OMIM:190030, murine Fes appears to be required for hemopoietic homeostasis); as loss of kin-5 activity via large-scale RNAi screens does not result in any obvious abnormalities, the precise role of kin-5 in C. elegans development and/or behavior is not yet known. T13H2.3 T13H2.3 Protein containing two C3HC4 type (RING) zinc fingers, has a region of low similarity to a region of ring finger protein 2 (mouse Rnf2), which interacts with a transcriptional repressor and may be involved in development T13H2.4 T13H2.4 Protein with weak similarity to S. cerevisiae SNF5 (Component of SWI-SNF global transcription activator complex, acts to assist gene-specific activators through chromatin remodeling) The protein product of this gene is predicted to contain a glutamine/asparagine (Q/N)-rich ('prion') domain, by the algorithm of Michelitsch and Weissman (as of the WS77 release of WormBase, i.e., in wormpep77). T13H5.1 T13H5.1 Member of the protein-tyrosine phosphatase family, has low similarity to receptor-type protein tyrosine phosphatase epsilon (human PTPRE), which exists in cytoplasmic and transmembrane forms and may be involved in brain inflammation protein-tyrosine phosphatase T13H5.2 T13H5.2 Protein containing a CRAL-TRIO domain, has low similarity to SEC14-like 2 (tocopherol-associated protein, human SEC14L2), which is an alpha-tocopherol-binding protein that activates transcription in an alpha-tocopherol-dependent manner retinal-binding like protein T13H5.3 T13H5.3 Member of the glycosyl hydrolase 18 family, has a region of low similarity to chitinase 1 (chitotriosidase, human CHIT1), which catalyzes the hydrolysis of chitin and is associated with chitotriosidase deficiency upon gene mutation chitinase-like repeats T13H5.4 T13H5.4 Protein with high similarity to spliceosome-associated protein 61 (human SF3A3), which is a subunit of the heterotrimeric splicing factor SF3a that is involved in the formation of the 17S U2 snRNP and assembly of the prespliceosome PRP9 like protein T13H5.5 T13H5.5 Possible mitochondrial small ribosomal subunit protein T13H5.6 T13H5.6 Protein with weak similarity to C. elegans Y39B6B.GG T13H5.7 T13H5.7 Putative ortholog of C. elegans rnh2 gene product T13H5.8 T13H5.8 Putative ortholog of C. elegans R166.2 gene product T13H5.8 is the closest C. elegans homolog of the human gene CRR9, which promotes cisplatin-induced apoptosis in ovarian cancer cells, and of CLPTM1, a human gene associated with cleft lip and palate. T14A8.1 T14A8.1 Protein with weak similarity to H. sapiens Hs.931 (Homo sapiens type IIA myosin heavy chain mRNA, partial cds) The ric-3 gene encodes a novel, highly charged protein with two transmembrane domains and extensive coiled-coil domains; it is necessary for the function of at least four nicotinic acetylcholine receptors; specifically, it is needed for assembly or trafficking of the DEG-3 nicotinic acetylcholine receptor. T14A8.2 T14A8.2 Protein of unknown function that may be anchored to the membrane of a secretory vesicle or the Golgi apparatus T14B1.1 T14B1.1 Protein of unknown function expressed in hypodermis, neurons, and muscle T14B1.2 T14B1.2 G protein-coupled receptor with weak similarity to human alpha-adrenergic and galanin receptors possible G protein coupled receptor T14B4.1 T14B4.1 Member of the RNA methyltransferase family, which may be 2'-O-methyltransferases, has a region of low similarity to a region of TAR (HIV) RNA-binding protein 1 (human TARBP1), which is an RNA-binding protein involved in regulating HIV gene expression rRNA methylase; This gene encodes a protein predicted by Eisenberg and coworkers, with 52% accuracy, to be mitochondrial. T14B4.2 T14B4.2 Protein of unknown function T14B4.3 T14B4.3 Protein with moderate similarity to C. elegans R03E1.2 gene product T14B4.4 T14B4.4 Member of the tetraspanin family, which contain an N-terminal transmembrane domain that is a signal sequence and membrane anchor transpanin T14B4.5 T14B4.5 Protein of unknown function T14B4.6 dpy-2;rol-2;T14B4.6 Collagen of the collagen triple helix repeat (20 copies) family The dpy-2 gene encodes an unusual cuticular collagen that is required for maintaining the normal body length of the animal in later larval stages; dpy-2 interacts with other cuticular collagens such as dpy-10 and sqt-1, and suppresses mutations in glp-1, mup-1, and emb-5. T14B4.7 dpy-10;rol-7;T14B4.7 Collagen similar to DPY-2 collagen A cuticle collagen protein that afffects body morphology and movement and genetically interacts with the sqt-1 collagen gene. T14B4.8 T14B4.8 Protein of unknown function T14B4.9 T14B4.9 Member of the core-2 or I-branching enzyme family, which form blood group I-antigens or O-glycan side-chains, has weak similarity to human GCNT1, which forms O-glycan branched structures and is involved in Wiskott-Aldrich syndrome and multiple sclerosis T14C1.1 T14C1.1 Member of the rhodopsin family of G-protein coupled receptors (GPCR), has low similarity to uncharacterized C. elegans C56A3.3 7 transmembrane receptor (rhodopsin family); T14C1.1 encodes a homolog of the functionally active Fmrf Receptor (FR; CG2114) of D. melanogaster; it is thus possible that T14C1.1 is a receptor for one of the FMRF-like neurotransmitters in C. elegans (e.g., FLP-1 through FLP-12). T14C1.2 T14C1.2 Protein of unknown function, has high similarity to uncharacterized C. elegans F52E1.12 reverse transcriptase T14D7.1 T14D7.1 Putative serine-pyruvate aminotransferase serine-pyruvate aminotransferase; T14D7.1 is orthologous to the human gene ALANINE-GLYOXYLATE AMINOTRANSFERASE HOMOLOG (AGXT; OMIM:604285), which when mutated leads to disease. T14D7.2 T14D7.2 Member of the uncharacterized protein family UPF0063, has low similarity to uncharacterized C. elegans C31A11.5 T14D7.3 T14D7.3 Member of the synaptobrevin family, which are intrinsic membrane proteins found in small synaptic vesicles, has strong similarity to uncharacterized C. elegans C30A5.5 vesicle associated membrane protein T14E8.1 T14E8.1 Protein containing two protein kinase domains, has a region of moderate similarity to a region of met protooncogene (rat Met), which may function in cell proliferation, differentiation, and migration and in organ development protein-tyrosine kinase T14E8.2 T14E8.2 Protein of unknown function T14E8.3 T14E8.3 Member of the rhodopsin family of G-protein coupled receptors (GPCR), has a region of low similarity to dopamine D2 receptor (rat Drd2), which inhibits adenylyl cyclase, activates phospholipase D and is important in locomotory behavior G-protein coupled receptor (family 1) T14F9.1 T14F9.1 Protein of unknown function, has high similarity to uncharacterized human CGI-11 ATPase subunit T14F9.2 T14F9.2 Protein of unknown function T14F9.3 T14F9.3 Protein containing glycosyl hydrolase family 20 domain 2 and catalytic domains, has moderate similarity to hexosaminidase B (mouse Hexb), which is a subunit of an enzyme that catalyzes the degradation of ganglioside GM2 and blocks polyspermy beta-hexosaminidase beta subunit; T14F9.3 is orthologous to the human gene CERVICAL CANCER PROTO-ONCOGENE 7 (HEXB; OMIM:606873), which when mutated leads to disease. T14F9.4 peb-1;T14F9.4 DNA-binding protein involved in target gene activation in pharynx, vulva and hindgut morphogenesis T14F9.5 lin-32;T14F9.5 Basic helix-loop-helix (bHLH) protein required for expression of neuroblast cell fate hlh transcription factor T14G10.1 T14G10.1 Protein with high similarity to 3'-phosphoadenosine 5'-phosphosulfate synthase 2 (mouse Papss2), which has ATP sulfurylase and adenosine 5'-phosphosulfate kinase activites, contains an adenylylsulfate kinase domain and an ATP-sulfurylase domain sulphate adenyltransferase; pps-1 is orthologous to human PAPSS1 (OMIM:603262) and human PAPSS2 (OMIM:603005, mutated in spondyloepimetaphyseal dysplasia). T14G10.2 pxf;T14G10.2;ra-gef Protein containing three cyclic nucleotide-binding domains, three Ras association (RalGDS or AF6) domains, three ras guanine nucleotide exchange factor (GEF) domains, and three PDZ, DHR, or GLGF domains, has moderate similarity to human PDZ-GEF1 cell division control protein 25 like T14G10.3 T14G10.3 Member of the transthyretin-like family, has low similarity to uncharacterized C. elegans T14G10.4 Transthyretin-like family T14G10.4 T14G10.4 Member of the transthyretin-like family, has low similarity to uncharacterized C. elegans T14G10.3 Transthyretin-like family T14G10.5 T14G10.5 Protein containing a clathrin-associated adaptin N-terminal domain, which are components of coated vesicles, has moderate similarity to S. cerevisiae Sec21p, which is a coatomer (COPI) complex gamma chain (gamma-COP) of secretory pathway vesicles protein transport protein; T14G10.5 encodes a gamma subunit of the coatomer (COPI) complex; in mass RNAi assays, T14G10.5 is required for locomotion, fertility, normally rapid growth, and general health. T14G10.6 T14G10.6 Member of the tetraspanin family, has low similarity to kangai 1 (human KAI1), which may be involved in the progression of prostatic and colorectal and possibly esophegeal, cervical, lung, and breast cancers tetraspanin T14G10.7 T14G10.7 Protein of unknown function T14G10.8 T14G10.8 Protein of unknown function T14G11.1 T14G11.1 Protein of unknown function T14G11.3 T14G11.3 Protein of unknown function, has low similarity to uncharacterized C. elegans W06H3.1 L96 protein (tipula iridescent virus (TIV) (weak)) T14G12.1 T14G12.1 Protein containing a paired box (PAX) domain, has low similarity to tcA transposase (C. elegans C03E10.2) transposase and homeobox paired-box protein T14G12.2 T14G12.2 Member of the synaptosome-associated protein 25 kD (SNAP-25) family, which are components of SNARE complexes synaptosomal associated protein 25A (SNAP-25A) T14G12.3 fil-1;beta-filagenin;T14G12.3 Protein of unknown function, has low similarity to uncharacterized C. elegans R13H4.2 T14G12.4 fkh-2;T14G12.4 Putative forkhead transcription factor; strongly similar to C. elegans C47G2.2; functions redundantly with PES-1 fork head domain transcription factor (SLP2, D. melanogaster); fkh-2 encodes one of 15 forkhead transcriptional regulators encoded by the C. elegans genome, and is homologous to Drosophila sloppy-paired (slp) and the vertebrate Brain Factor 1 (BF-1, OMIM:164874, expression is restricted to the central nervous system); by homology, FKH-2 is predicted to function as a transcription factor that regulates gene expression during development; while loss of fkh-2 activity via RNA-mediated interference (RNAi) results only in mild locomotion defects in L1 larvae, further RNAi experiments indicate that fkh-2 and pes-1, which encodes another C. elegans forkhead transcription factor, are required redundantly for completion of embryonic and larval development; fkh-2 expression, which partially overlaps that of pes-1, is detected in embryos in descendants of the D and AB founder cell lineages. T14G12.5 T14G12.5 Member of the reverse transcriptase protein family, which are RNA-dependent DNA polymerases, contains a retroviral integrase core domain, which can act as endonucleases, has high similarity to uncharacterized C. elegans T05A1.4 reverse transcriptase and Epstein-Barr virus large tegument protein T14G12.6 T14G12.6 Member of an uncharacterized protein family T14G8.1 chd-3;T14G8.1 Likely Chromodomain-Helicase-DNA-binding protein with strong identity to human CHD-3 helicase-DNA-binding like protein; chd-3 encodes a PHD-finger SNF2 family member containing a chromo domain and a C-terminal helicase domain that affects Notch-dependent vulval development; expressed in virtually all embryonic cells and in many larval nuclei. T14G8.2 T14G8.2 Protein of unknown function This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins. T14G8.3 T14G8.3 Member of the Hsp70 family, which are stress-induced protein chaperones, has low similarity to oxygen regulated protein 150 kDa (human ORP150), which is a putative endoplasmic reticulum chaperone for angiogenic factors such as human VEGF heat shock protein T14G8.4 T14G8.4 Protein of unknown function T15B12.1 T15B12.1 Protein containing a calponin homology (CH) domain, which bind actin, has a region of high similarity to a region of beta spectrin (human SPTB), which is a component of the erythrocyte membrane-associated cytoskeleton that is associated with spherocytosis T15B12.2 T15B12.2 Protein containing two protein kinase domains, has low similarity to casein kinase I (serine/threonine/tyrosine protein kinase, S. cerevisiae Hrr25p), which is involved in DNA repair and meiosis Protein kinase/Aldehyde dehydrogenase T15B7.1 T15B7.1 Protein containing a beta or gamma fibrinogen C-terminal globular domain, has moderate similarity to a region of ficolin 3 (Hakata antigen) (human FCN3), which is a thermolabile beta2-macroglycoprotein and an autoantigen in systemic lupus erythematosus T15B7.10 T15B7.10 Protein of unknown function, has strong similarity to C. elegans T15B7.8 T15B7.11 T15B7.11 G protein-coupled receptor of unknown function, has weak similarity to human somatostatin receptor T15B7.12 T15B7.12 G protein-coupled receptor of unknown function, no homolog found in human or D. melanogaster T15B7.13 T15B7.13 Protein with similarity to G protein-coupled receptors of C. elegans T15B7.14 T15B7.14 Protein of unknown function T15B7.15 T15B7.15 Protein with weak similarity to C. elegans nmy-2 (Nonmuscle myosin II heavy chain-related protein required for cytokinesis and establishment of early embryonic polarity) T15B7.16 T15B7.16 Protein containing neurotransmitter-gated ion-channel ligand binding and transmembrane domains, has low similarity to C. elegans UNC-49 ligand-gated ionic channel protein T15B7.17 T15B7.17 Protein of unknown function, putative paralog of C. elegans T15B7.7 T15B7.2 T15B7.2 Protein of unknown function, has low similarity to a region of butyrate-induced transcript 1 (human HSPC121), which functions in the biochemical pathway leading to activation of nuclear factor kappa B (NF-kappaB) and Jun N-terminal kinase (MAPK8) T15B7.3 T15B7.3 Protein containing two collagen triple helix repeats and a nematode cuticle collagen N-terminal domain, has a region of moderate similarity to a region of C. elegans BLI-1, which is a likely collagen acting in embryogenesis and chemotaxis collagen T15B7.4 T15B7.4 Protein containing two collagen triple helix repeats and one nematode cuticle collagen N-terminal domain, has a region of high similarity to a region of C. elegans BLI-1, which is a putative collagen involved in embryogenesis and chemotaxis collagen T15B7.5 T15B7.5 Protein containing two collagen triple helix repeats and a nematode cuticle collagen N-terminal domain, has a region of high similarity to a region of C. elegans BLI-1, which is a likely collagen involved in embryogenesis and morphogenesis and chemotaxis collagen T15B7.6 T15B7.6 Protein of unknown function, has moderate similarity to C. elegans T15B7.17; may be anchored to the membrane of a secretory vesicle or the Golgi apparatus T15B7.7 T15B7.7 Protein of unknown function, putative paralog of C. elegans F02C9.2 T15B7.8 T15B7.8 Protein of unknown function, has strong similarity to C. elegans Y45G12C.F T15B7.9 T15B7.9 Protein containing a C-type lectin domain, which mediate calcium-dependent carbohydrate recognition T15D6.1 T15D6.1 Member of an uncharacterized protein family T15D6.10 T15D6.10 Member of an uncharacterized protein family T15D6.11 T15D6.11 Member of the domain of unknown function DUF13 family, has high similarity to uncharacterized C. elegans T15D6.8 T15D6.12 T15D6.12 Member of an uncharacterized protein family T15D6.2 gly-16;T15D6.2 Member of the core-2 or I-branching enzyme family, which form blood group I-antigens or O-glycan side-chains, has low similarity to human GCNT1, which forms O-glycan branched structures and is involved in Wiskott-Aldrich syndrome and multiple sclerosis acetylglucosaminyltransferase; gly-16 encodes a protein similar to 2/I N-acetylglucosaminyltransferase; gly-16 is expressed in the seam cells during embryonic stages. T15D6.3 gly-17;T15D6.3 Member of the core-2 or I-branching enzyme family, which form blood group I-antigens or side-chains of O-glycans, has low similarity to leukocyte type core 2 beta-1,6-N-acetylglucosaminyltransferase (human GCNT1), which functions in the immune response acetylglucosaminyltransferase; gly-17 encodes a protein similar to 2/I N-acetylglucosaminyltransferase. T15D6.4 T15D6.4 Member of the acetylglucosaminyltransferase-like protein family T15D6.5 T15D6.5 Member of an uncharacterized protein family T15D6.6 nhr-77;T15D6.6 Member of the zinc finger protein family with similarity to nuclear hormone receptors Zinc finger, C4 type (two domains) T15D6.7 T15D6.7 Protein with moderate similarity to beta-1,3-glucuronyltransferase 3 (glucuronosyltransferase I, human B3GAT3), which is a type II transmembrane protein that catalyzes the transfer of glucuronic acid in proteoglycan biosynthesis T15D6.8 T15D6.8 Member of the domain of unknown function DUF13 family, has high similarity to uncharacterized C. elegans T15D6.11 T15D6.9 T15D6.9 Member of an uncharacterized protein family T15H9.1 T15H9.1 Member of the heat shock/DnaJ protein family T15H9.2 T15H9.2 Protein with weak similarity to H. sapiens MYH3 (myosin, heavy polypeptide 3, skeletal muscle, embryonic) coiled-coil T15H9.3 T15H9.3 Protein containing a helix-loop-helix DNA-binding domain, which mediate protein dimerization achaete-scute helix-loop-helix domain T15H9.4 T15H9.4 Protein of unknown function, has moderate similarity to uncharacterized C. elegans F10D11.5 T15H9.5 T15H9.5 Protein of unknown function, has high similarity to uncharacterized C. elegans F10D11.4 T15H9.6 T15H9.6 Putative poly(A) polymerase, has a predicted rol in mRNA 3' end formation poly(A) polymerase T16A1.1 T16A1.1 Protein containing four meprin and TRAF homology (MATH) domains, has low similarity to uncharacterized C. elegans F36H5.1 T16A1.2 T16A1.2 Member of an uncharacterized protein family T16A1.3 T16A1.3 Protein with strong similarity to C. elegans M02B7.1 gene product T16A1.4 T16A1.4 Protein of unknown function T16A1.5 T16A1.5 Protein of unknown function T16A1.7 T16A1.7 Putative ortholog of C. elegans W03B1.2 gene product The protein product of this gene is predicted to contain a glutamine/asparagine (Q/N)-rich ('prion') domain, by the algorithm of Michelitsch and Weissman (as of the WS77 release of WormBase, i.e., in wormpep77). T16A1.8 T16A1.8 Protein containing an F-box domain, which serve as a link between a target protein and a ubiquitin-conjugating enzyme, has moderate similarity to uncharacterized C. elegans F58E1.3 This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins; its encoded protein also contains a Pfam-B45 motif of presently unknown function. T16A1.9 T16A1.9 Member of the reverse transcriptase protein family, which are RNA-dependent DNA polymerases T16A9.1 T16A9.1 Putative ortholog of C. elegans Y71A12B.K gene product T16A9.2 T16A9.2 Member of the 7-transmembrane chemoreceptor family of G-protein coupled receptors (GPCR), has moderate similarity to uncharacterized C. elegans C17E7.11 T16A9.3 T16A9.3 Protein of unknown function, has high similarity to uncharacterized C. elegans Y49F6B.8 T16A9.4 T16A9.4 Member of the M13 peptidase family of zinc metalloproteases, has low similarity to Mel transforming oncogene-like 1 (soluble secreted endopeptidase, mouse Mell1), which is a protease that may be involved in cleavage of intra- and extracellular peptides endothelin converting enzyme 1; T16A9.4 encodes a neprilysin; neprilysins are thermolysin-like zinc metallopeptidases, found on the outer surface of animal cells, that negatively regulate small signalling peptides (e.g., enkephalin, tachykinin, insulin, and natriuretic peptides) by cleaving them; while T16A9.4 has no clear orthologs in other organisms, it falls into a group of proteins that includes the classical neprilysins found in mammals (e.g., PEX [OMIM:307800] and the enkephalin cleaving enzymes). T16A9.5 T16A9.5 Protein of unknown function, has very strong similarity to uncharacterized C. elegans Y69E1A.A T16D1.1 T16D1.1 Protein of unknown function T16D1.2 T16D1.2 Member of the histidine acid phosphatase family, which hydrolyze phosphate esters at low pH, has low similarity to a region of lysosomal acid phosphatase (human ACP2), which is a tartrate-inhibitable lysosomal enzyme T16G1.1 T16G1.1 Protein of unknown function The protein product of this gene is predicted to contain a glutamine/asparagine (Q/N)-rich ('prion') domain, by the algorithm of Michelitsch and Weissman (as of the WS77 release of WormBase, i.e., in wormpep77). T16G1.10 T16G1.10 Protein containing one uncharacterized ACR domain, has moderate similarity to S. cerevisiae Dtd1p, which is a D-Tyr-tRNA[Tyr] deacylase The protein product of this gene was predicted to contain a glutamine/asparagine (Q/N)-rich ('prion') domain, by the algorithm of Michelitsch and Weissman (as of the WS72 release of WormBase, i.e., in wormpep77). T16G1.11 T16G1.11 Protein of unknown function The protein product of this gene was predicted to contain a glutamine/asparagine (Q/N)-rich ('prion') domain, by the algorithm of Michelitsch and Weissman (as of the WS72 release of WormBase, i.e., in wormpep77). T16G1.2 T16G1.2 Protein of unknown function T16G1.3 T16G1.3 Protein of unknown function, has high similarity to uncharacterized C. elegans T16G1.7 T16G1.4 T16G1.4 Member of an uncharacterized protein family T16G1.5 T16G1.5 Member of an uncharacterized protein family T16G1.6 T16G1.6 Member of an uncharacterized protein family T16G1.7 T16G1.7 Member of an uncharacterized protein family T16G1.7 is orthologous to the human gene ALIAS DLC1~CANDIDATE TUMOR SUPPRESSOR GENE (DLEC1; OMIM:604050), which when mutated leads to disease. T16G1.8 T16G1.8 Protein of unknown function containing a Ground-like domain, has weak similarity to C. elegans F42C5.7 T16G1.9 T16G1.9 Protein containing three ankyrin (Ank) repeats, which may mediate protein-protein interactions Ank repeat T16G12.1 T16G12.1 Putative aminopeptidase (SANGER), has strong similarity to H. sapiens ANPEP gene product [aminopeptidase] Aminopeptidase T16G12.3 T16G12.3 Protein of unknown function, putative paralog of C. elegans H11L12.1 T16G12.4 T16G12.4 Protein of unknown function T16G12.5 T16G12.5 Protein of unknown function T16G12.6 T16G12.6 Protein with unknown function T16G12.7 T16G12.7 PP1-type serine/threonine protein phosphatase Protein phosphatase 1 T16G12.8 T16G12.8 Protein of unknown function T16H12.1 T16H12.1 Protein of unknown function T16H12.10 T16H12.10 Protein of unknown function, has moderate similarity to C. elegans T16H12.8 T16H12.2 T16H12.2 Protein of unknown function T16H12.3 T16H12.3 Protein of unknown function T16H12.4 T16H12.4 Protein with moderate similarity to ]general transcription factor IIH polypeptide 2 (human GTF2H2), which is a subunit of general transcription initiation factor TFIIH involved in initiation and elongation and may be involved in Cockayne syndrome transcription factor IIH subunit T16H12.5 T16H12.5 Protein containing a meprin and TRAF homology (MATH) domain, and a BTB (BR-C, ttk and babor) or POZ (Pox virus and zinc finger) domain, has low similarity to C. elegans MEL-26, which is a negative regulator of the meiotic-spindle protein C. elegans MEI-1 Kruppel-like zinc finger protein (outside zinc fingers); The T16H12.5 gene encodes a protein with a meprin-associated Traf homology (MATH) domain that may be involved in apoptosis. T16H12.6 T16H12.6 Protein containing five Kelch motif domains and a BTB (BR-C, ttk and babor) or POZ (Pox virus and zinc finger) domain, has weak similarity to kelch-like 2 (Mayven) (human KLHL2), which is a protein-binding protein and putative transporter MIPP repeats T16H12.8 T16H12.8 Member of an uncharacterized protein family T16H12.9 T16H12.9 Protein of unknown function, has weak similarity to C. elegans B0222.9 T16H5.1 T16H5.1 Member of the integral membrane innexin family, which are involved in the formation of gap junctions, has moderate similarity to C. elegans UNC-9, which is required for normal locomotion inx-19 encodes a predicted member of the innexin family that affects body size and growth. T17A3.1 T17A3.1 Protein containing three immunoglobulin (Ig) domains and a protein kinase domain, has weak similarity to fms related tyrosine kinase 1 (vascular endothelial growth factor-vascular permeability factor receptor) (human FLT1), which functions in angiogenesis protein kinase T17A3.10 T17A3.10 Protein of unknown function, has moderate similarity to uncharacterized C. elegans F40G9.8 T17A3.11 T17A3.11 Protein with strong similarity to C. elegans K08G2.7 gene product T17A3.2 T17A3.2 Member of an uncharacterized protein family T17A3.3 T17A3.3 Protein containing an F-box domain, which serve as a link between a target protein and a ubiquitin-conjugating enzyme, has high similarity to uncharacterized C. elegans T17A3.4 This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins; its encoded protein also contains a Pfam-B45 motif of presently unknown function. T17A3.4 T17A3.4 Protein containing an F-box domain, which serve as a link between a target protein and a ubiquitin-conjugating enzyme, has high similarity to uncharacterized C. elegans T17A3.3 This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins; its encoded protein also contains a Pfam-B45 motif of presently unknown function. T17A3.6 T17A3.6 Member of an uncharacterized protein family T17A3.7 T17A3.7 Protein containing an F-box domain, which serve as a link between a target protein and a ubiquitin-conjugating enzyme, has high similarity to uncharacterized C. elegans T17A3.4 This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins; its encoded protein also contains a Pfam-B45 motif of presently unknown function. T17A3.8 T17A3.8 Protein containing three protein kinase domains, a ZZ zinc finger, and an immunoglobulin (Ig) domain, which may be involved in protein-protein and protein-ligand interactions, has a region of low similarity to C. elegans KIN-15 protein kinase T17A3.9 T17A3.9 Protein of unknown function, has strong similarity to C. elegans VW02B12L.4 T17E9.1 kin-18;Sulu;T17E9.1 Protein containing a protein kinase domain, has moderate similarity to thousand and one amino acid protein kinase (rat Tao1), which associates with Mek3 and is involved in regulating the p38-containing stress responsive MAP kinase pathway T17E9.2 T17E9.2 Protein with high similarity to human NMT2, which is an n-myristoyltransferase that catalyzes the N-myristoylation of proteins, contains a myristoyl-CoA:protein N-myristoyltransferase N-terminal domain and a C-terminal domain T17H7.1 T17H7.1 Protein containing a DUF148 domain of unknown function, has a region of low similarity to a region of collagen type IV alpha 2 (human COL4A2), which is a basement membrane component T17H7.3 T17H7.3 Protein of unknown function T17H7.4 T17H7.4 Putative ortholog of C. elegans T17H7.5 gene product gei-16 can encode a protein with similarity to the B20 antigen of the parasitic nematode Onchocerca volvulus; GEI-16 is required for ventral enclosure and elongation during embryonic development, larval development, and normal rates of postembryonic growth; GEI-16 interacts with GEX-3, a homolog of mammalian protein ligands of the small GTPase Rac1 that is also essential for embryonic morphogenesis. T17H7.7 T17H7.7 Protein of unknown function T18D3.1 T18D3.1 Protein with weak similarity to C. elegans T13A10.5 T18D3.2 odr-7;T18D3.2 Member of the zinc finger, C4 type (two domains) protein family, involved in AWA-mediated chemosensation of volatile odorants Zinc finger, C4 type (two domains); The odr-7 gene encodes an olfactory specific member of the nuclear receptor superfamily that affects chemotaxis to some volatile odorants and the cell fate of the AWA neuron; it is expressed in AWA neurons. T18D3.3 T18D3.3 Protein with high similarity to zinc transporter 2 (rat Slc30a2), which transports zinc into vesicles and may protect cells from zinc toxicity by inducing zinc accumulation in a lysosomal or endosomal compartment, member of the cation efflux family cobalt uptake like protein T18D3.4 myo-2;mhc-c;Myosin;T18D3.4 Protein with high similarity to sarcomeric myosin heavy chain (C. elegans UNC-54), which is a component of thick filaments in muscle, contains a myosin head domain, a myosin N-terminal SH3-like domain, and two coiled-coil myosin heavy chain tail regions myosin heavy chain C; myo-2 encodes a muscle-type specific myosin heavy chain isoform; myo-2 is expressed in pharyngeal muscle. T18D3.5 T18D3.5 Protein of unknown function T18D3.6 T18D3.6 Protein of unknown function T18D3.7 T18D3.7 Member of the TSC-22, dip, or bun family, which may act as transcriptional regulators TSC-22 / dip / bun family T18D3.8 T18D3.8 Protein of unknown function T18H9.1 grd-6;T18H9.1 Protein with strong similarity to C. elegans GRD-8, has weak similarity to C. elegans MUC1, transmembrane mucin 1 grd-6 encodes a protein that contains a novel Ground domain; may be expressed in the hypodermis and in some neurons. T18H9.2 asp-2;T18H9.2 Probable aspartyl protease protease; asp-2 encodes aspartic protease. T18H9.4 T18H9.4 Member of the 7-transmembrane chemoreceptor family of G-protein coupled receptors (GPCR), has low similarity to C. elegans ODR-10, which is involved in odorant response 7TM chemoreceptor, str family T18H9.5 opu-10;inx-10;T18H9.5 Member of the integral membrane innexin family, which are involved in the formation of gap junctions, has a region of moderate similarity to C. elegans UNC-9, which is required for normal locomotion type-1 membrane protein; inx-10 encodes an innexin, an integral transmembrane channel protein that is a structural component of invertebrate gap junctions; as loss of INX-10 function via RNA-mediated interference (RNAi) does not result in any abnormalities, the precise role of INX-10 in C. elegans development and/or behavior is not yet known; INX-10 is broadly expressed and detected in the developing embryonic pharynx and in larvae and adults in the pharyngeal corpus and terminal bulb, the sheath, several ventral cord neurons, rectal epithelial cells, the developing spermathecum, and in a few vulval cells. T18H9.6 T18H9.6 Protein of unknown function T19A5.1 T19A5.1 Protein containing three TPR (tetratrico peptide repeat) domains, which may mediate protein-protein interactions T19A5.2 T19A5.2 Protein containing three protein kinase domains, has a region of high similarity to serine threonine kinase 25 (human STK25), which is a oxidant stress-activated kinase that may regulate a novel oxidative stress response intracellular signaling pathway serine/threonine kinase; gck-1 encodes a member of the germinal center kinase III (GCK-III) family of Ste20PAK kinases that affects fertility due to improper meiotic prophase progression and interacts with AIR-2 in yeast two-hybrid assays; associated with P-granules in embryos and dissected gonads, and localizes to the mitotic cleavage furrow in embryonic somatic cells. T19A5.3 T19A5.3 Protein of unknown function T19A5.4 nhr-44;T19A5.4 Member of the nuclear hormone receptor/Zinc finger protein family zinc finger protein T19A5.5 T19A5.5 Protein containing a nuclear hormone receptor ligand-binding domain and a nuclear hormone receptor C4-type zinc finger domain, which bind DNA and may be involved in regulation of transcription, has low similarity to C. elegans NHR-58 zinc finger protein T19A6.1 T19A6.1 Protein with weak similarity to S. cerevisiae YMR010W T19A6.2 T19A6.2 Member of an uncharacterized GTPase family, has a region of low similarity to S. cerevisiae Nug1p, which is a nuclear protein required for 60S ribosomal subunit export from the nucleus AUTOANTIGEN NGP-1 T19A6.3 T19A6.3 Member of an uncharacterized protein family T19A6.4 T19A6.4 Putative ortholog of C. elegans W02D3.4 gene product T19B10.1 T19B10.1 Member of the cytochrome P450 family, has moderate similarity to cytochrome P450 4B1 (human CYP4B1), which is a putative risk factor for bladder cancer that is involved in the detoxification response and metabolism of drugs and lipids cytochrome P450 T19B10.10 T19B10.10 Protein containing a neurotransmitter-gated ion-channel ligand binding domain, has a region of low similarity to gamma aminobutyric acid receptor subunit alpha 6 (human GABRA6), which is a subunit of a benzodiazepine receptor and chloride channel T19B10.11 max-1;mxl-1;T19B10.11 Member of the MAX family of basic helix-loop-helix DNA-binding proteins Helix-loop-helix DNA-binding domain T19B10.2 T19B10.2 Protein of unknown function T19B10.3 T19B10.3 Member of the glycosyl hydrolases family 35 of beta-galactosidases, has moderate similarity to beta galactosidase 1 (mouse Glb1), which catalyzes cleavage of the terminal galactose from gangliosides, glycoproteins, and glycosaminoglycans beta-galactosidase; The T19B10.3 gene encodes an ortholog of the human gene GALACTOSIDASE, BETA 1 (GLB1), which when mutated leads to gangliosidosis type I (OMIM:230500). T19B10.4 T19B10.4 Protein of unknown function The protein product of this gene is predicted to contain a glutamine/asparagine (Q/N)-rich ('prion') domain, by the algorithm of Michelitsch and Weissman (as of the WS77 release of WormBase, i.e., in wormpep77). T19B10.5 T19B10.5 Protein containing a PDZ, DHR, or GLGF domain, which are found in signaling proteins PDZ domain (Also known as DHR or GLGF).; T19B10.5 encodes a protein with partial similarity to human PERIAXIN (PRX; OMIM:605725), which when mutated leads to Dejerine-Sottas neuropathy. T19B10.6 T19B10.6 Protein of unknown function T19B10.7 ima-1;T19B10.7 Member of the karyopherin-alpha protein family; meiosis-specific protein associated with the nuclei of developing germ cells that have finished pachytene importin alpha, nuclear transport factor; ima-1 encodes a member of the importin family. T19B10.8 T19B10.8 Protein of unknown function, has a region of weak similarity to a region of S. cerevisiae Bst1p, which negatively regulates COPII vesicle formation and is required for proper vesicle cargo sorting Yeast hyptothetical protein YFC5 like T19B10.9 T19B10.9 Protein with strong similarity to C. elegans CD4.5 gene product max protein like T19B4.1 T19B4.1 Member of the copper type II ascorbate-dependent monooxygenase family, contains four NHL repeats, which are often associated with RING finger and B-box motifs, has low similarity to peptidylglycine alpha-amidating monooxygenase (mouse Pam) monooxygenase T19B4.2 T19B4.2 Protein with weak similarity to C. elegans F53F10.5 gene product T19B4.3 T19B4.3;1G247 Protein with high similarity to adenine phosphoribosyltransferase (human APRT), which is an adenine salvage enzyme implicated in 2,8-dihydroxyadenine (DHA) urolithiasis and renal failure, contains a phosphoribosyl transferase domain adenine phosphoribosyltransferase T19B4.4 T19B4.4 Protein containing a DnaJ domain, which are part of a chaperone (protein folding) system that mediates interaction with heat shock proteins, has high similarity to uncharacterized human MCJ This gene encodes a protein containing a DnaJ ('J') domain. T19B4.5 T19B4.5 Protein of unknown function T19B4.6 unc-40;unc-91;T19B4.7;T19B4.6 Type 1 transmembrane receptor of motile cells and axonal processes required for ventrally-directed guidance of circumferential movement along the epidermis; similar to vertebrate DCC (Deleted in Colorectal Cancer) and neogenin T19C3.1 T19C3.1 Member of the C. elegans putative membrane protein family 8, has moderate similarity to a region of bestrophin (human VMD2), which functions in vision and may be associated with vitelliform macular dystrophy and bull's eye maculopathy T19C3.2 T19C3.2 Protein of unknown function, has low similarity to uncharacterized C. elegans Y54F10AM.6 T19C3.3 T19C3.3 Protein of unknown function T19C3.4 T19C3.4 Member of the TB2 or DP1 and HVA22 related protein family, has high similarity to uncharacterized human FLJ13110 Polyposis locus protein 1 T19C3.5 T19C3.5 Protein containing two N- and one C-terminal lipopolysaccharide-binding protein, bactericidal permeability-increasing protein, or cholesteryl ester transfer protein domains, has weak similarity to lipopolysaccharide (LPS)-binding protein (human LBP) T19C3.6 T19C3.6 Protein of unknown function T19C3.7 T19C3.7 Protein of unknown function, has weak similarity to C. elegans F53B2.3 protein phosphatase 2c T19C3.8 fem-2;isx-2;T19C3.8 Serine/threonine protein phosphatase required for male germ line and somatic gonad development; type 2C phosphatase A CB5161 ortholog of fem-2, Cs-fem-2, has been isolated from the sibling Caenorhabditis species CB5161. T19C4.1 T19C4.1 Protein with weak similarity to H. sapiens Hs.129892 (Homo sapiens mRNA for KIAA0522 protein, partial cds) T19C4.2 T19C4.2 Protein of unknown function, has low similarity to uncharacterized C. elegans T19C4.3 T19C4.3 T19C4.3 Protein of unknown function, has high similarity to uncharacterized C. elegans C51F7.2 T19C4.4 T19C4.4 Protein with strong similarity to C. elegans T19C4.3 gene product G-protein coupled receptor, srg family T19C4.5 T19C4.5 Protein of unknown function T19C4.6 gpa-1;T19C4.6 Member of the G protein alpha subunit family guanine nucleotide-binding protein; gpa-1 encodes a member of the G protein alpha subunit family of heterotrimeric GTPases that is involved in chemotaxis to water-soluble odorants; it is expressed in sensory neurons and in the spicule and phasmid neurons of the male tail. T19C4.7 T19C4.7 Protein of unknown function T19C9.1 T19C9.1 Protein containing a DUF40 domain of unknown function, which contain four conserved cysteines, has strong similarity to uncharacterized C. elegans F08E10.2 7TM receptor, srbc family T19C9.2 T19C9.2 Member of the 7-transmembrane chemoreceptor family of G-protein coupled receptors (GPCR), has strong similarity to uncharacterized C. elegans F08E10.6 G-protein coupled receptor, srh family T19C9.3 T19C9.3 Member of the 7-transmembrane chemoreceptor family of G-protein coupled receptors (GPCR), has strong similarity to uncharacterized C. elegans F08E10.5 G-protein coupled receptor, srh family T19C9.4 T19C9.4 Member of the 7-transmembrane chemoreceptor family of G-protein coupled receptors (GPCR), has high similarity to uncharacterized C. elegans F08E10.6 G-protein coupled receptor, srh family T19C9.5 T19C9.5 Protein of unknown function, has strong similarity to uncharacterized C. elegans F08E10.7 T19C9.6 T19C9.6 Protein containing a DUF141 domain of unknown function T19C9.7 T19C9.7 Member of the reverse transcriptase protein family, which are RNA-dependent DNA polymerases, has high similarity to uncharacterized C. elegans R05A10.1 Reverse transcriptase (RNA-dependent DNA polymerase) T19C9.8 T19C9.8 Protein of unknown function, has low similarity to uncharacterized C. elegans C29F3.7 T19D12.1 T19D12.1 Protein of unknown function, has a region of low similarity to a region of sialophorin (leukosialin, human SPN), which is an integral membrane protein that binds ICAM-1 and has roles in T-cell activation and neutrophil migration A. faecalis PHB depolymerase; zinc finger protein 40 T19D12.10 T19D12.10 Member of the sugar (and other) transporter family, has low similarity to solute carrier family 17 member 1 (human SLC17A1), which is involved in sodium-dependent phosphate transport and mediates organic anion transport at the renal apical membrane sodium/phosphate trasnsprter T19D12.2 T19D12.2 Putative ortholog of C. elegans T19D12.1 gene product A. faecalis PHB depolymerase T19D12.3 T19D12.3 Putative ortholog of C. elegans T19D12.2 gene product T19D12.4 T19D12.4 Protein containing a von Willebrand factor (vWF) type A domain T19D12.5 T19D12.5 Protein containing a protein kinase domain, has low similarity to casein kinase 1 alpha 1 (rat Csnk1a1), which is a serine/threonine protein kinase that may play a role in signal transduction casein kinase I T19D12.6 T19D12.6 Protein containing an extracellular laminin G domain, has weak similarity to a region of agrin (rat Agrn), which is a proteoglycan component of the basal lamina that stimulates acetylcholine receptor aggregation through the activation of rat Nsk1 laminin repeats; EGF-like repeats T19D12.7 T19D12.7 Protein of unknown function T19D12.8 T19D12.8 Protein of unknown function, has high similarity to uncharacterized C. elegans F28C12.4 7TM chemoreceptor, sra family T19D12.9 T19D12.9 Member of the sugar (and other) transporter family, has low similarity to solute carrier family 17 member 1 (human SLC17A1), which is involved in sodium-dependent phosphate transport and mediates organic anion transport at the renal apical membrane sodium/phosphate trasnsprter T19D2.1 T19D2.1 Member of the reprolysin (M12B) zinc metalloprotease family, which are also called adamalysins, contains seven type 1 thrombospondin domains, has weak similarity to human ADAMTS1, which is a disintegrin metalloprotease that inhibits cell proliferation T19D2.2 prl-1;T19D2.2 Protein with similarity to mammalian PRL-1 protein tyrosine phosphatases protein-tyrosine phosphotase T19D2.3 T19D2.3 Protein of unknown function T19D7.1 T19D7.1 Protein with moderate similarity to C. elegans T27E9.9 gene product T19D7.2 T19D7.2 Protein of unknown function, has weak similarity to C. elegans W04G3.8 T19D7.3 T19D7.3 Protein of unknown function T19D7.4 T19D7.4 Protein containing a RUN domain, which may be involved in Ras-like GTPase signaling pathways T19D7.5 T19D7.5 Protein of unknown function T19D7.6 T19D7.6 Protein of unknown function T19D7.7 T19D7.7 Putative ortholog of C. elegans Y9C12A.B gene product T19E10.1 T19E10.1 Protein containing four BRCA1 (breast cancer type 1) C terminus (BRCT) domains and two RhoGEF (GTPase exchange factor) domains, has weak similarity to epithelial cell transforming sequence 2 (human ECT2), which is a guanine nucleotide exchange factor transforming protein etc2 T19E10.2 T19E10.2 Protein of unknown function T19E7.1 T19E7.1 Protein with C-type lectin family domain T19E7.2 skn-1;T19E7.2 Transcription factor required for early embryogenesis T19E7.3 T19E7.3 Protein of unknown function, has low similarity to a region of beclin (mouse Becn1), which is a mouse Bcl2-interacting protein that protects cells from viral-induced apoptosis and may also act as a tumor suppressor and inhibit cellular proliferation bec-1 encodes a coiled-coil protein that is orthologous to the yeast and mammalian autophagy proteins Apg6/Vps30p/beclin1; bec-1 activity is required for normal dauer morphogenesis and survival of dauer larvae, as well as for adult life span extension of daf-2(e1370) mutants at 15 degrees; in addition, loss of bec-1 activity by large-scale RNAi indicates that BEC-1 is required for normal growth rates, movement, and vulval morphogenesis; by homology, BEC-1 may be part of a Class III phosphatidylinositol 3-kinase complex that plays a role in localizing autophagy proteins to preautophagosomal structures, and overexpression of C. elegans bec-1 in S. cerevisiae APG6/VPS30 mutants can rescue associated autophagy defects; a bec-1::GFP reporter fusion is expressed in the hypodermis, intestine, nervous system, pharynx, and reproductive organs, all tissues that are remodelled during dauer larval development. T19E7.5 T19E7.5 Protein of unknown function, has moderate similarity to uncharacterized C. elegans C39H7.6 7TM chemoreceptor, srd family T19F4.1 T19F4.1 Member of the rhodopsin family of G-protein coupled receptors (GPCR), has weak similarity to orexin (hypocretin) receptor 2 (rat Hcrtr2), which may stimulate feeding behavior and function in sleep and wakefulness T19H12.1 T19H12.1 Member of the UDP-glucuronosyltransferase protein family UDP-glucuronosyltransferase T19H12.10 T19H12.10 Protein containing a UDP-glucoronosyl and UDP-glucosyl transferase domain, has weak similarity to UDP-glucuronosyltransferase 8 (UDP-galactose ceramide galactosyltransferase, rat Ugt8), which catalyzes the formation of galactosylceramide from ceramide UDP-glucuronosyltransferase T19H12.11 T19H12.11 Protein containing a UDP-glucoronosyl and UDP-glucosyl transferase domain, has low similarity to UDP glycosyltransferase 2 family polypeptide B15 (human UGT2B15), which glucuronidates steroids and several xenobiotics UDP-glucuronosyltransferase T19H12.2 T19H12.2 Protein with low similarity to putative human HLA class II associated protein 1 (human ANP32), which is a protein phosphatase inhibitor and a tumor suppressor that may control nuclear shape T19H12.3 T19H12.3 Putative ortholog of C. elegans T19H12.9 gene product T19H12.4 T19H12.4 Protein of unknown function, has moderate similarity to uncharacterized C. elegans T19H12.5 7TM chemoreceptor, srd family T19H12.5 T19H12.5 Protein of unknown function, has moderate similarity to uncharacterized C. elegans T19H12.4 7TM chemoreceptor, srd family T19H12.6 T19H12.6 Member of the gamma-glutamyltranspeptidase family, which catalyze transfer of the gamma-glutamyl moiety of glutathione to an acceptor, has a region of low similarity to gamma-glutamyl transferase (gamma glutamyl transpeptidase, mouse Ggtp) T19H12.7 T19H12.7 Member of the 7-transmembrane chemoreceptor family of G-protein coupled receptors (GPCR), has low similarity to C. elegans ODR-10, which is involved in odorant response 7TM chemoreceptor, str family T19H12.8 nhr-D;T19H12.8 Protein containing two nuclear hormone receptor C4-type zinc finger domains, which bind DNA and may be involved in regulation of transcription, has moderate similarity to C. elegans NHR-58, which is a putative nuclear receptor involved in morphogenesis nuclear hormone receptor T19H12.9 T19H12.9 Member of the UDP-glucuronosyltransferase protein family UDP-glucuronosyltransferase T19H5.1 T19H5.1 Member of the glycosyl hydrolase 18 family, has a region of low similarity to a region of chitinase 1 (human CHIT1), which catalyzes the hydrolysis of chitin and is associated with Gaucher disease and chitotriosidase deficiency chitinase-like repeats T19H5.2 T19H5.2 Member of the glycosyl hydrolase 18 family, has low similarity to uncharacterized C. elegans R09D1.2 T19H5.3 T19H5.3 Protein with strong similarity to C. elegans R09D1.11 gene product T19H5.4 T19H5.4 Protein of unknown function T20B12.1 T20B12.1 Protein containing eight TPR (tetratrico peptide repeat) domains, which may mediate protein-protein interactions, has low similarity to uncharacterized human FLJ20272 T20B12.2 tbp-1;CeTBP;TBP;T20B12.2;3H475 TATA-binding protein; required for basal transcription tbp-1 encodes the C. elegans ortholog of the human TATA-box-binding protein (TBP; OMIM:600075; mutated in spinocerebellar ataxia 17); consistent with its proposed role in transcriptional regulation, TBP-1 has been shown to provide TFIID-like basal transcription activity in human and C. elegans extracts, to bind specifically to a TATA box sequence, and to interact with TFIIA and TFIIB transcription factors from other species; large-scale RNA-mediated interference (RNAi) screens indicate that tbp-1 activity is required for embryonic and larval development, as well as for normal rates of postembryonic growth. T20B12.3 T20B12.3 Protein of unknown function T20B12.4 T20B12.4 Protein of unknown function, has moderate similarity to uncharacterized C. elegans Y45G5AM.3 T20B12.4 is orthologous to the human gene INTERLEUKIN 2 RECEPTOR, GAMMA (SEVERE COMBINED IMMUNODEFICIENCY) (IL2RG; OMIM:308380), which when mutated leads to disease. T20B12.5 T20B12.5 Protein of unknown function T20B12.6 myc;mio;T20B12.6 Protein containing two helix-loop-helix DNA-binding domains, which mediate protein dimerization, and two cyclin C-terminal domains, has low similarity to Williams-Beuren syndrome chromosome region 14 (mouse Wbscr14) T20B12.7 T20B12.7 Protein of unknown function T20B12.8 T20B12.8 Contains a high mobility group box (HMG1 or 2) family domain, has moderate similarity to structure-specific recognition protein 1 (human SSRP1), which is a transcription cofactor that binds DNA in regions of bending or unwinding hmg-4 encodes a protein with strong similarity to the highly conserved high mobility group protein SSRP1 (structure-specific DNA recognition protein); by homology, HMG-4 is predicted to be a member of the FACT (facilitates chromatin transcription) complex that functions as a transcription elongation factor; RNAi experiments indicate that hmg-4 is required for locomotion and larval development, and required redundantly with hmg-3, its paralog, for embryonic development. T20B12.9 T20B12.9 Protein containing neurotransmitter-gated ion-channel ligand binding and transmembrane domains, has moderate similarity to C. elegans MOD-1, which is a serotonin-gated chloride channel T20B3.1 T20B3.1 Member of the choline or carnitine o-acyltransferase family, has low similarity to carnitine O-octanoyltransferase (human CROT), which converts branched and medium chain fatty acyl-CoA to carnitine esters and acts in peroxisomal fatty acid beta-oxidation Carnitate acyltransferase T20B3.12 T20B3.12 Protein containing two C-type lectin domains, which mediate calcium-dependent carbohydrate recognition, has high similarity to uncharacterized C. elegans Y102A5B.1 Lectin C-type domain short and long forms T20B3.13 T20B3.13 Protein containing two C-type lectin domains, has a region of low similarity to a region of macrophage mannose receptor C1 (mouse Mrc1), which acts in the uptake and clearance of mannose-containing microorganisms and glycoproteins Lectin C-type domain short and long forms T20B3.2 T20B3.2 Member of the troponin family, which regulate calcium-induced muscle contraction, has high similarity to uncharacterized C. elegans ZK721.2 Troponin T20B3.3 T20B3.3 Member of the 7-transmembrane chemoreceptor family of G-protein coupled receptors (GPCR), has high similarity to uncharacterized C. elegans T20B3.5 T20B3.4 T20B3.4 Member of the 7-transmembrane chemoreceptor family of G-protein coupled receptors (GPCR), has high similarity to uncharacterized C. elegans T20B3.5 T20B3.5 T20B3.5 Member of the 7-transmembrane chemoreceptor family of G-protein coupled receptors (GPCR), has high similarity to uncharacterized C. elegans Y113G7B.2 T20B3.6 T20B3.6 Protein of unknown function T20B3.7 vhl-1;T20B3.7 Involved in response to hypoxia with similarity to human proline 4-hydroxylase alpha subunits; has strong similarity to C. elegans C14E2.4 T20B3.8 T20B3.8 Protein containing two C-type lectin domains, has low similarity to a region of macrophage mannose receptor C1 (human MRC1), which acts in the uptake and clearance of microorganisms and host glycoproteins T20B5.1 T20B5.1 Protein with high similarity to alpha-adaptin-C (human AP2A2), which interacts with human HD, contains an alpha adaptin AP2 C-terminal domain, an adaptin C-terminal domain, and a clathrin-associated adaptin N-terminal domain alpha-adaptin; The apt-4 gene encodes an adaptin: specifically, it encodes an ortholog of the alpha subunit of adaptor protein complex 2 (AP-2). T20B5.2 T20B5.2 Protein of unknown function T20B5.3 T20B5.3 Protein with low similarity to meningioma expressed antigen 5 (human MGEA5), which is a tumor antigen with both hyaluronidase and beta-N-acetylglucosaminidase activity T20B5.3 encodes an ortholog of mammalian O-GlcNAc selective N-acetyl-beta-D-glucosaminidase (O-GlcNAcase), an enzyme distinct from lysosomal hexosaminidases that removes O-GlcNAc modifications from intracellular proteins; T20B5.3 has no obvious phenotype in mass RNAi screens; T20B5.3 is predicted to be located in both the cytoplasm and the nucleus, to counteract O-linked N-acetylglucosamine (O-GlcNAc) transferase, and to be needed for rapid changes of O-GlcNAc modification in signal transduction. T20B6.1 T20B6.1 Member of the protein-tyrosine phosphatase family, has low similarity to a region of protein tyrosine phosphatase receptor type alpha (mouse Ptpra), which is a receptor tyrosine phosphatase that negatively regulates proliferation protein-tyrosine phosphatase T20B6.2 T20B6.2 Protein of unknown function, has strong similarity to C. elegans Y55D5A_391.C T20B6.3 T20B6.3 Protein of unknown function, has weak similarity to D. melanogaster collagen type IV protein VKG T20C4.1 T20C4.1 Putative ortholog of C. elegans T28A11.9 gene product 7TM chemoreceptor, srj family T20C7.1 T20C7.1 Putative ortholog of C. elegans K07C6.10 gene product T20D3.1 T20D3.1 Protein with strong similarity to C. elegans F26A1.12 gene product T20D3.11 T20D3.11 Protein of unknown function, has similarity to human KIAA0233 protein (isolated from KG-1 cell line cDNA library) T20D3.2 T20D3.2 Protein of unknown function, has high similarity to uncharacterized C. elegans Y53G8AM.5 T20D3.3 T20D3.3 Protein of unknown function T20D3.5 T20D3.5 Member of the mitochondrial carrier protein family of membrane transporters ADP/ATP carrier protein like T20D3.6 T20D3.6 Protein with weak similarity to S. cerevisiae YML030W T20D3.7 T20D3.7 Protein with low similarity to S. cerevisiae Pep8p, which is involved in vacuolar protein targeting H(beta)58 protein T20D3.8 T20D3.8 Protein with low similarity to phosphatidylinositol glycan class C (GPI GlcNAc transferase C, human PIGC), which is a subunit of the GPI GlcNAc transferase complex that catalyzes the transfer of N-acetylglucosamine in GPI anchor biosynthesis T20D3.9 T20D3.9 Protein of unknown function, has strong similarity to C-terminal half of human KIAA0233 protein (Hs.79077, isolated from a myeloblast cDNA library) T20D4.1 T20D4.1 Protein of unknown function, has high similarity to uncharacterized C. elegans C36C5.2 7TM chemoreceptor, srab family T20D4.10 T20D4.10 Member of an uncharacterized protein family T20D4.11 T20D4.11 Member of an uncharacterized protein family T20D4.12 T20D4.12 Member of an uncharacterized protein family T20D4.13 T20D4.13 Putative ortholog of C. elegans F35F10.1 gene product T20D4.15 T20D4.15 Protein of unknown function, has strong similarity to C. elegans F35F10.13 T20D4.16 T20D4.16 Protein of unknown function, has weak similarity to C. elegans F35F10.13 T20D4.17 T20D4.17 Protein of unknown function, has moderate similarity to C. elegans T28A11.3 T20D4.18 T20D4.18 Protein of unknown function, has strong similarity to uncharacterized C. elegans C36C5.2 7TM chemoreceptor, srab family T20D4.19 T20D4.19 Protein of unknown function, has moderate similarity to C. elegans F10G2.1 T20D4.2 T20D4.2 Protein of unknown function, has high similarity to uncharacterized C. elegans C36C5.2 7TM chemoreceptor, srab family T20D4.3 T20D4.3 Protein of unknown function, has moderate similarity to uncharacterized C. elegans F35F10.10 T20D4.4 T20D4.4 Protein of unknown function, has moderate similarity to uncharacterized C. elegans C04E12.3 T20D4.5 T20D4.5 Protein of unknown function, has moderate similarity to uncharacterized C. elegans C04E12.5 T20D4.6 T20D4.6 Protein of unknown function, has a region of low similarity to a region of vitamin D-3 upregulated protein-1 (mouse Txnip), which is induced by oxidative stress and functions as an oxidative stress mediator by inhibiting thioredoxin activity T20D4.7 T20D4.7 Protein with high similarity to C. elegans R05H5.3, which is a putative nuclear thioredoxin involved in embryogenesis and morphogenesis T20D4.8 T20D4.8 Member of the M13 peptidase family of zinc metalloproteases, has high similarity to uncharacterized C. elegans Y19D10B.6 T20D4.8 encodes a neprilysin; neprilysins are thermolysin-like zinc metallopeptidases, found on the outer surface of animal cells, that negatively regulate small signalling peptides (e.g., enkephalin, tachykinin, insulin, and natriuretic peptides) by cleaving them; T20D4.8 has no clear orthologs in other organisms. T20D4.9 T20D4.9 Member of the M13 peptidase family of zinc metalloproteases, has high similarity to uncharacterized C. elegans Y19D10B.6 T20D4.9 encodes a neprilysin; neprilysins are thermolysin-like zinc metallopeptidases, found on the outer surface of animal cells, that negatively regulate small signalling peptides (e.g., enkephalin, tachykinin, insulin, and natriuretic peptides) by cleaving them; T20D4.9 has no clear orthologs in other organisms. T20F10.1 T20F10.1 Protein containing a protein kinase domain and a protein kinase C-terminal domain, has moderate similarity to Large Tumor Suppressor 1 (human LATS1), which is a serine/threonine kinase that functions in cell cycle control and control of mitosis Protein kinase C terminal domain T20F10.2 T20F10.2 Protein contains a putative coiled-coil domain, has weak similarity to C. elegans myo-3 gene product [A/Band-1/myosin/K12F2.1 Sarcomeric myosin heavy chain, minor component required for thick filaments in body-wall muscle] T20F10.4 T20F10.4 Protein of unknown function, putative paralog of C. elegans Y40C7B.A T20F10.5 T20F10.5 Protein of unknown function, has weak similarity to C. elegans C41D11.7 T20F5.1 T20F5.1 Protein of unknown function T20F5.2 pbs-4;T20F5.2 Putative beta-type subunit of 20S proteasome particle peptidase; pbs-4 encodes a B-type subunit of the 26S proteasome's 20S protease core particle; by homology, PBS-4 is predicted to function in ATP/ubiquitin-dependent nonlysosomal protein degradation; loss of pbs-4 activity via RNAi indicates that, in C. elegans, PBS-4 is required for embryonic, germline, and larval development. T20F5.3 T20F5.3 Member of the ribosome recycling factor family, which dissociate ribosomes from mRNA after termination of translation T20F5.4 T20F5.4 Protein of unknown function T20F5.5 T20F5.5 Protein of unknown function T20F5.6 T20F5.6 Protein containing a C3HC4 type (RING) zinc finger, which may mediate protein-protein interactions zinc finger protein T20F5.7 T20F5.7 Protein containing a C3HC4 type (RING) zinc finger, which may mediate protein-protein interactions T20F7.1 T20F7.1 Protein of unknown function T20F7.2 T20F7.2 Protein containing two C2H2 type zinc finger domains, which bind nucleic acids T20F7.3 T20F7.3 Protein of unknown function, has a region of low similarity to a region of inositol hexakisphosphate kinase 2 (regulator of IFN-induced death-2, human IHPK2), which phosphorylates inositol hexaphosphate to yield diphosphoinositol pentakisphosphate T20F7.5 T20F7.5 Putative ortholog of C. elegans T20F7.4 gene product T20F7.6 T20F7.6 Protein containing four CBS (cystathionine-beta-synthase) domains, has moderate similarity to a region of AMP-activated protein kinase gamma 3 (human PRKAG3), which is a regulatory subunit of AMP-activated protein kinase and serves in energy homeostasis AMP-activated protein kinase T20F7.7 T20F7.7 Member of the AMP-binding enzyme family, has weak similarity to C. albicans Acs1p, which is acetyl-coenzyme A synthetase (acetate-CoA ligase) AMP-binding protein; This gene encodes a protein predicted by Eisenberg and coworkers, with 52% accuracy, to be mitochondrial. T20G5.1 Ce-chc;T20G5.1 Clathrin heavy chain Clathrin heavy chain T20G5.10 T20G5.10 Protein of unknown function, has high similarity to uncharacterized general control of amino acid synthesis-like 1 (human GCN5L1) T20G5.11 T20G5.11 Protein contains two double-stranded RNA binding domains Double-stranded RNA binding motif T20G5.12 T20G5.12 Protein containing a DB module domain, has high similarity to uncharacterized C. elegans C56C10.4 T20G5.13 T20G5.13 Protein with strong similarity to C. elegans ZK1010.4 gene product T20G5.2 T20G5.2 Member of the citrate synthase protein family Citrate synthase; cts-1 encodes a citrate synthase, predicted to be mitochondrial, that is required for embryonic development. T20G5.3 mua-3;T20G5.3;Ynx3 Transmembrane cell adhesion receptor MUA-3 precursor, member of the EGF-repeat protein family T20G5.4 T20G5.4 Member of the C. elegans putative membrane protein family 8, has low similarity to a region of bestrophin (human VMD2), which plays a role in vision and is associated with several macular pathologies Putative membrane protein T20G5.5 T20G5.5 Protein containing two cyclic nucleotide-binding domains, a ras guanine nucleotide exchange factor (GEF) and N-terminal domain, and a domain of unknown function, has low similarity to cAMP-regulated guanine nucleotide exchange factor II (human CAMP-GEFII) cAMP dependent protein kinase regulatory chain + guanine nucleotide releasing factors T20G5.6 unc-47;T20G5.6 Vesicular GABA transporter (VGAT) unc-47 encodes a novel transmembrane vesicular GABA transporter; UNC-47 and UNC-46, a predicted novel transmembrane protein, are required in GABAergic neurons for all GABA neurotransmission, specifically for loading of GABA into synaptic vesicles, where UNC-47 is localized; UNC-47 is required for the localization of UNC-46, and when overexpressed can rescue unc-46 mutant animals; UNC-47 expression in type D neurons is transcriptionally regulated by the UNC-30 homeodomain protein. T20G5.7 T20G5.7 Protein of unknown function, has strong similarity to uncharacterized C. elegans T20G5.8 T20G5.8 T20G5.8 Protein of unknown function, has moderate similarity to C. elegans T20G5.7 T20G5.9 T20G5.9 Protein of unknown function, has weak similarity to C. elegans E04D5.1 T20H12.1 T20H12.1 Protein of unknown function T20H12.2 T20H12.2 Member of the Tc3 Transposase protein family transposase T20H4.1 T20H4.1 Protein containing a major sperm protein (MSP) domain, which are involved in sperm motility T20H4.2 T20H4.2 Protein containing two C2H2 type zinc finger domains, which bind nucleic acids T20H4.3 T20H4.3 Putative glutamyl-prolyl-tRNA synthetase Prolyl-tRNA synthetase region; prs-1 encodes a predicted cytoplasmic prolyl-tRNA synthetase (ProRS), a class II aminoacyl-tRNA synthetase that catalyzes the attachment of proline to its cognate tRNA and is thus required for protein biosynthesis; PRS-1 is required for embryonic, germline, and postembryonic development. T20H4.4 adr-1;T20H4.4;ADAR Predicted to be an adenosine deaminase that acts on RNA adr-2 encodes an adenosine deaminase that acts on RNA (ADAR); ADARs are RNA-editing enzymes that deaminate adenosines to create inosines in double-stranded RNA (dsRNA); adr-2 is expressed ubiquitously in early embryos, as well as in the germline of early adults; ADR-2 is required for ADAR activity in vivo, and for normal chemotaxis. T20H4.5 T20H4.5 Putative 23 kDa subunit of NADH-coenzyme Q reductase, possible ortholog of human NDUFS8, 23 kDa subunit of NADH dehydrogenase (ubiquinone) Fe-S complex Mitochondrial complex I 23K chain; The T20H4.5 gene encodes an ortholog of the human gene NADH DEHYDROGENASE-UBIQUINONE FE-S PROTEIN 8 23 KDA SUBUNIT; MITOCHONDRIAL COMPLEX I TYKY SUBUNIT (NDUFS8; OMIM:602141), which when mutated leads to Leigh syndrome (OMIM:256000); the T20H4.5 protein is predicted to be mitochondrial with 52% accuracy. T20H9.1 T20H9.1 Protein containing a DUF38 domain of unknown function, has moderate similarity to uncharacterized C. elegans ZC47.6 T20H9.2 T20H9.2 Protein containing a DUF38 domain of unknown function T20H9.3 T20H9.3 Protein containing a DUF38 domain of unknown function, has weak similarity to feminization of germline 2 (C. elegans FOG-2), which is required for the sexual identity of germ cells T20H9.4 T20H9.4 Protein containing a DUF38 domain of unknown function, has weak similarity to C. elegans FOG-2, which is required for the sexual identity of germ cells T20H9.5 T20H9.5 Protein containing a DUF38 domain of unknown function and an F-box domain, which serve as a link between a target protein and a ubiquitin-conjugating enzyme, has low similarity to C. elegans FOG-2, which is required for the sexual identity of germ cells This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins; this gene's encoded protein also contains an FTH/DUF38 motif, which may also mediate protein-protein interaction. T20H9.6 T20H9.6 Protein containing a WSN domain of unknown function, has low similarity to uncharacterized C. elegans Y22D7AR.2 T21B10.1 T21B10.1 Possible mitochondrial large ribosomal subunit protein T21B10.2 T21B10.2 Protein with high similarity to enolase 1 (human ENO1, alpha enolase) which converts 2-phospho-D-glycerate to phosphoenolpyruvate in glycolysis and is an autoantigen in multiple autoimmune diseases, member of the enol-ase family enolase; T21B10.2 is orthologous to human ENOLASE 1 (also CRYSTALLIN, TAU; ENO1; OMIM:172430), which when mutated leads to spherocytic red cell enolase deficiency. T21B10.3 T21B10.3 Protein with strong similarity to C. elegans B0035.6 gene product T21B10.4 T21B10.4 Protein of unknown function, has moderate similarity to uncharacterized C. elegans F13D12.5 T21B10.5 T21B10.5 Protein containing a SET domain, has a region of moderate similarity to a region of B lymphocyte-induced maturation protein 1 (human PRDM1), which is a transcription factor that promotes B-cell maturation and represses human beta-interferon expression transcriptional repressor like T21B10.6 T21B10.6 Protein of unknown function, has a region of low similarity to a region of C. elegans CUT-1, which is a cuticulin component cuticlin like T21B10.7 cct-2;T21B10.7 Member of the chaperonin complex protein family t-complex protein 1 T21B4.1 T21B4.1 Protein containing a DUF216 domain of unknown function T21B4.10 T21B4.10 Member of the 7-transmembrane chemoreceptor family of G-protein coupled receptors (GPCR), has moderate similarity to uncharacterized C. elegans T27E7.2 T21B4.11 T21B4.11 TcA transposase Tc1 transposase T21B4.12 T21B4.12 Member of the G protein-coupled receptor protein family 7TM receptor, srx family T21B4.2 T21B4.2 Protein containing a nematode cuticle collagen N-terminal domain, has a region of moderate similarity to a region of the alpha 1 subunit of type II collagen (human COL2A1), which is involved in cartilage development and maintenance collagen T21B4.3 T21B4.3 Protein containing one C. elegans C-terminal C6 domain, which contain conserved cysteine residues, has moderate similarity to uncharacterized C. elegans R07B1.5 T21B4.4 T21B4.4 Member of the rhodopsin family of G-protein coupled receptors (GPCR), has low similarity to A3 adenosine receptor (mouse Adora3), which binds a pertussis toxin sensitive G protein and is involved in inflammatory responses and mast cell degranualization adenosine A1 receptor T21B4.5 T21B4.5 Member of the 7-transmembrane chemoreceptor family of G-protein coupled receptors (GPCR), has high similarity to uncharacterized C. elegans T21B4.6 7TM receptor T21B4.6 T21B4.6 Member of the 7-transmembrane chemoreceptor family of G-protein coupled receptors (GPCR), has high similarity to uncharacterized C. elegans T21B4.5 7TM receptor T21B4.7 T21B4.7 Member of the 7-transmembrane chemoreceptor family of G-protein coupled receptors (GPCR), has high similarity to uncharacterized C. elegans T21B4.9 7TM receptor T21B4.8 T21B4.8 Member of the 7-transmembrane chemoreceptor family of G-protein coupled receptors (GPCR), has moderate similarity to uncharacterized C. elegans T21B4.9 7TM receptor T21B4.9 T21B4.9 Member of the 7-transmembrane chemoreceptor family of G-protein coupled receptors (GPCR), has high similarity to uncharacterized C. elegans T21B4.7 7TM receptor T21B6.1 dgn-1;T21B6.1 Protein with strong similarity to C. elegans F56C3.6 gene product T21B6.2 T21B6.2 Member of the histidine acid phosphatase family, has low similarity to prostatic acid phosphatase (human ACPP), which is a phosphatase that is expressed in prostate epithelium in response to androgens and negatively regulates cell growth histidine acid phosphatase T21B6.3 T21B6.3 Protein containing a PAN domain and six type 1 thrombospondin domains, has a region of low similarity to a region of semaphorin F (mouse Sema5a), which is differentially expressed during early embryogenesis f-spondin like protein; The protein product of this gene is predicted to contain a glutamine/asparagine (Q/N)-rich ('prion') domain, by the algorithm of Michelitsch and Weissman (as of the WS77 release of WormBase, i.e., in wormpep77). T21B6.4 T21B6.4 Protein of unknown function T21B6.5 T21B6.5 Protein with strong similarity to D. melanogaster CG9620 (CG9620 gene product) T21C12.1 unc-49;T21C12.1 Protein with strong similarity across the N-terminal half to ligand-gated ion channels of human, D. melanogaster, and C. elegans gamma-aminobutyric-acid receptor T21C12.2 T21C12.2 Protein with high similarity to 4-hydroxyphenylpyruvic acid dioxygenase (mouse Hpd), which is an enzyme of tyrosine catabolism that is associated with hereditary tyrosinemia, member of the glyoxalase, bleomycin resistance or dioxygenase superfamily 4-hydroxyphenylpyruvate dioxygenase; hpd-1 encodes a 4-hydroxyphenylpyruvate dioxygenase that is required for normally short lifespan and negative regulation of the dauer larval stage, with loss of hpd-1 function prolonging lifespan and promoting dauer formation; hpd-1 is a (perhaps evolutionarily conserved) target of transcriptional activation by DAF-16; HPD-1 is orthologous to human HPD (OMIM:276710, mutated in tyrosinemia type III). T21C12.3 T21C12.3;3K628 Protein of unknown function T21C12.4 T21C12.4 Protein of unknown function T21C9.1 T21C9.1 Protein containing a PDZ, DHR, or GLGF domain, which are found in signaling proteins discs large like repeats T21C9.10 T21C9.10 Protein of unknown function T21C9.11 T21C9.11 Protein with strong similarity to C. elegans T21C9.13 gene product T21C9.12 T21C9.12 Member of the NLI interacting factor family, has a region of low similarity to a region of S. cerevisiae Psr2p, which is a plasma membrane phosphatase required for sodium stress response REV protein (anti-repression transactivator protein) T21C9.13 T21C9.13 Protein with strong similarity to C. elegans T21C9.11 gene product T21C9.2 vps-54;T21C9.2 Protein of unknown function, has low similarity to uncharacterized human HCC8 Zinc finger, C2H2 type; The vps-54 gene encodes an ortholog of VPS54 in S. cerevisiae, a protein involved in vacuolar trafficking. T21C9.4 T21C9.4 Member of the enhancer of rudimentary protein family Enhancer of rudimentary T21C9.5 T21C9.5 Protein of unknown function T21C9.6 T21C9.6 Protein containing a pyruvate phosphate dikinase, phosphoenolpyruvate (PEP) or pyruvate binding domain, which catalyze conversion of ATP to AMP, pyrophosphate and PEP, and a phosphoenolpyruvate-utilizing enzyme mobile domain, which are swivelling domains pyruvate, water dikinase; This gene encodes a protein predicted by Eisenberg and coworkers, with 68% accuracy, to be mitochondrial. T21C9.7 T21C9.7 Protein of unknown function, has moderate similarity to uncharacterized C. elegans F21F8.1 G-protein coupled receptor, srg family T21C9.8 T21C9.8 Member of the transthyretin-like family, has high similarity to uncharacterized C. elegans F09F3.6 Transthyretin-like family T21C9.9 T21C9.9 Protein of unknown function T21D11.1 T21D11.1 Member of the matrixin family, which are extracellular matrix metalloproteases that may be involved in tissue remodeling, has a region of moderate similarity to a region of matrix metalloproteinase 28 (epilysin, human MMP28) zinc protease T21D12.11 T21D12.11 Protein with weak similarity to C. elegans F35C5.3 gene product T21D12.12 T21D12.12 Member of an uncharacterized protein family protease inhibitor T21D12.2 T21D12.2 Protein containing two collagen triple helix repeats, has moderate similarity to a region of type XI collagen alpha 1 (human COL11A1), which is a component of cartilage and the vitreous of the eye and is associated with Type 2 Stickler syndrome cuticular collagen; dpy-9 encodes a cuticular collagen family member with similarity to human collagen alpha 5, type IV, and affects body length. T21D12.3 T21D12.3 Protein containing a WW domain, which bind proline-rich peptide epitopes, has low similarity to polyglutamine binding protein 1 (mouse Pqbp1), which functions as a transcriptional co-repressor and binds to polyglutamine tracts of several proteins T21D12.4 pat-6;T21D12.4 Protein with high similarity to parvin alpha (actopaxin, human PARVA), which is a focal adhesion protein that binds integrin-linked kinase (human ILK) and regulates cell adhesion and spreading, contains a calponin homology (CH) domain, which bind actin pat-6 encodes the worm ortholog of alpha-parvin; it is required for muscle assembly and function, with mutations leading to embryonic lethality. T21D12.5 T21D12.5 Member of the 7-transmembrane chemoreceptor family of G-protein coupled receptors (GPCR), has moderate similarity to uncharacterized C. elegans C47A10.2 7TM chemoreceptor, srh family T21D12.6 T21D12.6 Protein containing six GLTT repeat region domains T21D12.7 T21D12.7 Member of the EGF-repeat protein family protease inhibitor T21D12.9 T21D12.9 Member of the C. elegans putative membrane protein family 8, contains leucine rich repeats, 11 immunoglobulin domains, four leucine rich repeat C-terminal domains and three N-terminal domains, has a region of moderate similarity to bestrophin (human VMD2) T21D9.1 T21D9.1 Protein containing two collagen triple helix repeats and one nematode cuticle collagen N-terminal domain, has moderate similarity to a region of alpha 1 subunit of type XI collagen (mouse Col11a1), which functions in the development of the skeletal system procollagen alpha T21D9.2 T21D9.2 Protein of unknown function T21E12.2 T21E12.2 Protein of unknown function T21E12.3 T21E12.3 Protein of unknown function, has weak similarity to C. elegans ZC581.6 T21E12.4 dhc-1;T21E12.4 Member of the dynein heavy chain protein family, required for many events in one-cell stage embryos dynein heavy chain; dhc-1 encodes a cytoplasmic dynein heavy chain homolog required in one-cell embryos for pronuclear migration, centrosome separation, centrosome proximity to the male pronucleus, and mitotic spindle orientation, suggesting that DHC-1 helps position the microtubule organizing center; DHC-1 genetically interacts with SPD-5, a coiled-coil centrosomal protein. T21E12.5 T21E12.5 Protein of unknown function T21E3.1 T21E3.1 Member of the protein-tyrosine phosphatase family, has a region of low similarity to a region of protein tyrosine phosphatase non-receptor type 9 (human PTPN9), which is a non-membrane spanning tyrosine phosphatase that may be associated with autism T21E3.2 T21E3.2 Protein of unknown function T21E3.3 T21E3.3 Protein containing 18 low-density lipoprotein receptor class A domains, eight epidermal growth factor-like domains and eight class B low-density lipoprotein receptor repeats, has weak similarity to mouse Fbn2, which is an extracellular matrix protein EGF-like protein T21E8.1 T21E8.1 Member of the ABC transporter family, which are involved in translocation of a variety of compounds across biological membranes, contains two ABC transporter transmembrane domains, has moderate similarity to C. elegans C47A10.1 p-glycoprotein; This gene encodes a protein predicted by Eisenberg and coworkers, with 52% accuracy, to be mitochondrial. T21E8.2 T21E8.2 Member of the ABC transporter family, which are involved in translocation of a variety of compounds across biological membranes, contains two ABC transporter transmembrane domains, has moderate similarity to C. elegans C47A10.1 p-glycoprotein; This gene encodes a protein predicted by Eisenberg and coworkers, with 52% accuracy, to be mitochondrial. T21E8.3 T21E8.3 Member of the ABC transporter family, which are involved in translocation of a variety of compounds across biological membranes, contains two ABC transporter transmembrane domains, has moderate similarity to C. elegans C47A10.1 p-glycoprotein; This gene encodes a protein predicted by Eisenberg and coworkers, with 68% accuracy, to be mitochondrial. T21E8.4 T21E8.4 Protein of unknown function T21E8.5 T21E8.5 Protein of unknown function T21F2.1 T21F2.1 Protein containing neurotransmitter-gated ion-channel ligand binding and transmembrane domains, has moderate similarity to C. elegans MOD-1, which is a serotonin-gated chloride channel ligand-gated ionic channel T21F4.1 URH;T21F4.1 Putative ureohydrolase, member of an arginase enzyme family T21F4.1 is orthologous to the human gene ARGINASE TYPE I ERYTHROID VARIANT (ARG1; OMIM:207800), which when mutated leads to argininemia. T21G5.1 T21G5.1 Protein containing two protein kinase domains and a Src homology 2 (SH2) domain, which are regulatory modules of intracellular signaling, has low similarity to fer (fps/fes related) tyrosine kinase (mouse Fert2) tyrosine-protein kinase T21G5.2 T21G5.2 Protein of unknown function T21G5.3 glh-1;T21G5.3 RNA helicase in the germ line and localized to P granules; putative ortholog of S. cerevisiae DBP1 gene product [ATP-dependent RNA helicase of the DEAD box family] RNA helicase; glh-1 encodes a putative DEAD-box RNA helicase that contains four CCHC zinc fingers and is homologous to Drosophila VASA, a germ-line-specific, ATP-dependent RNA helicase; at permissive temperature, GLH-1 is required redundantly with GLH-4 for proper germ-line development and fertility, specifically for regulating the normal extent of germ-line proliferation, oogenesis, and the production of functional sperm; GLH-1 activity is also likely required for the wild-type morphology of P granules and for localization of several protein components, such as PGL-1, but not for accumulation of P granule mRNAs; GLH-1 interacts in vivo with CSN-5, a COP9 signalosome component, and in vitro with itself and with KGB-1, a JNK-like MAP kinase, ZYX-1, a LIM domain-containing zyxin homologue, and GLH-3; GLH-1 is a constitutive P granule component and thus, with the exception of mature sperm, is expressed in germ cells at all stages of development; consistent with its P granule localization, GLH-1 is cytoplasmic in oocytes and the early embryo, while perinuclear in all later developmental stages as well as in the distal and medial regions of the hermaphrodite gonad; GLH-1 is also expressed in males. T21G5.4 T21G5.4 Protein with very strong similarity to C. elegans C25G4.6, which is a protein required for spermatogenesis, contains two PDZ, DHR, or GLGF domains, which are found in signaling proteins T21G5.5 T21G5.5 Protein containing a KH domain, which may bind RNA, has a region of high similarity to a region of C. elegans GLD-1, which is an RNA binding protein that is required for transition from mitosis to meiosis during spermatogenesis and oogenesis T21H3.1 T21H3.1 Member of the lipase class 3 family, which are a subset of lipolytic enzymes that hydrolyze ester linkages of triglycerides, has high similarity to uncharacterized C. elegans F28H7.3 T21H3.2 ptr-16;T21H3.2 Member of the patched family, which are transmembrane receptors, has weak similarity to a region of Niemann-Pick disease type C1 (human NPC1), which is invoved in cholesterol transport and endocytosis and is associated with Niemann-Pick disease T21H3.3 cmd-1;T21H3.3 Calmodulin calmodulin; cmd-1 encodes a putative homolog of calmodulin 1 that affects growth rate and fertility. T21H3.4 T21H3.4 Protein of unknown function, has weak similarity to uncharacterized C. elegans Y53H1B.1 T21H3.5 T21H3.5 Protein of unknown function T21H8.1 Celiprin-beta;T21H8.1 Protein containing two SAM (sterile alpha motif) domains, has low similarity to PTPRF interacting protein binding protein 1 (liprin beta 1, human PPFIBP1), which is a beta liprin that binds to alpha liprins T21H8.2 T21H8.2 Protein of unknown function, has low similarity to uncharacterized C. elegans T21H8.4 7TM receptor, sra family T21H8.3 T21H8.3 Member of C. elegans Sra integral membrane protein family, which contain 6-7 hydrophobic putative transmembrane regions, has high similarity to uncharacterized C. elegans T21H8.4 7TM receptor like T21H8.4 T21H8.4 Protein of unknown function, has high similarity to uncharacterized C. elegans T21H8.3 7TM receptor like T21H8.5 T21H8.5 Protein of unknown function T22A3.2 T22A3.2 Member of the Hsp20 or alpha crystallin family, has moderate similarity to a region of alpha B crystallin (human CRYAB), which is a molecular chaperone that prevents protein aggregation in the lens and cardiac and skeletal muscle alpha crystallin B chain T22A3.3 T22A3.3 Protein of unknown function lst-1 encodes an unfamiliar protein with no known homologs outside of nematodes; in two-hybrid assays, LST-1 does not interact with control baits, but does interact with GPA-6, LAG-1, MPK-1 and K06A1.4, suggesting broad or unspecific interaction activity; however, T22A3.3 solely binds the normal form of GPA-6, without binding its constitutively active mutant form; LST-1 is expressed in head neurons (AWB, ADF, ASG, various interlabial sensory), socket cells, sheath cells in the nose tip, pharyngeal muscle, and intestine; LST-1 has no obvious function or phenotype in RNAi assays. T22A3.4 T22A3.4 Protein containing an MYND finger domain, has low similarity to uncharacterized C. elegans ZC8.3 T22A3.5 T22A3.5 Protein containing a WW domain, which bind proline-rich peptide epitopes, and a double-stranded RNA binding domain T22A3.6 T22A3.6 Protein containing a kringle domain, which may regulate proteolytic activity and may bind mediators such as membranes, other proteins or phospholipids kringle domain T22A3.8 T22A3.8 Putative ortholog of C. elegans C54D1.5 gene product laminin B; lam-3 is orthologous to human LAMININ ALPHA-2 (LAMA2; OMIM:156225), which when mutated leads to merosin-deficient congenital muscular dystrophy. T22B11.1 T22B11.1 Protein of unknown function, has weak similarity to C. elegans F22D3.4 T22B11.2 T22B11.2 Member of the galactosyltransferase family, which transfer galactose to GlcNAc termini of growing oligosaccharide chains, has moderate similarity to uncharacterized C. elegans C02H6.1 T22B11.3 T22B11.3 Protein containing a protein kinase domain, has low similarity to a region of fibroblast growth factor receptor 1 (mouse Fgfr1), which is a fibroblast growth factor receptor tyrosine kinase that is involved in cell proliferation and organ development ser/thr protein kinase T22B11.4 T22B11.4 Protein of unknown function, has weak similarity to human kinase scaffold protein GRAVIN (Hs.788) T22B11.5 T22B11.5 Protein with high similarity to 2-oxoglutarate dehydrogenase (alpha-ketoglutarate dehydrogenase, human OGDH), which converts alpha-ketoglutarate to succinyl coA and may act in Alzheimer's and Parkinson's disease, member of the dehydrogenase E1 family 2-oxoglutarate dehydrogenase; The T22B11.5 gene encodes an ortholog of the human gene OGDH, which when mutated leads to alpha-ketoglutarate deficiency (OMIM:203740); the T22B11.5 protein is predicted to be mitochondrial with 68% accuracy. T22B2.1 T22B2.1 Protein of unknown function, has high similarity to uncharacterized C. elegans Y73C8C.8 T22B2.2 T22B2.2 Protein of unknown function T22B2.3 T22B2.3 Protein of unknown function T22B2.4 T22B2.4 Protein containing an RNA recognition motif (RRM, RBD, or RNP), has low similarity to a region of deleted in azoospermia associated protein 1 (human DAZAP1), which is an RNA-binding protein that may play a role in spermatogenesis RNA-binding protein T22B2.5 T22B2.5 Protein of unknown function T22B2.6 T22B2.6 Protein containing an uncharacterized DUF139 cysteine repeat domain T22B2.7 T22B2.7 Protein of unknown function, has high similarity to uncharacterized C. elegans H24K24.1 T22B3.1 dpy-20;T22B3.1 Protein containing a BED zinc finger domain DPY-20 protein; dpy-20 encodes a BED zinc finger protein, with no known homologs outside of nematodes, that is required for normal body morphology. T22B3.2 T22B3.2 Protein containing two piwi domains and two PAZ (Piwi, Argonaut and Zwille) domains, which may mediate protein-protein interactions, has moderate similarity to C. elegans ALG-1, which is involved in C. elegans LIN-4 stRNA (small temporal RNA) production T22B3.3 T22B3.3 Protein containing a major sperm protein (MSP) domain, which are involved in sperm motility, has low similarity to uncharacterized C. elegans K05F1.9 T22B7.1 cog-2;T22B7.1 SOX family transcription factor required for formation of a vulva-uterine connection egl-13 encodes a transcription factor of the HMG (high mobility group) box family that affects the cell fusion process that makes the vulval-uterine connection and thereby affects egg laying; expressed in the pi lineage cells, transiently expressed in the rho lineage, in the anchor cell following fusion, and in neurons, body wall muscles, and intestinal cells. T22B7.2 T22B7.2 Protein with strong similarity to C. elegans F38H4.5 gene product T22B7.3 T22B7.3 Protein with strong similarity to C. elegans F38H4.5 gene product T22B7.4 T22B7.4 Protein with strong similarity to C. elegans Y17G9B.8 gene product T22B7.5 T22B7.5 Protein of unknown function, has weak similarity to C. elegans F53F1.7 7TM chemoreceptor, srv family T22B7.6 T22B7.6 Protein with weak similarity to members of the SRG subfamily of G protein-coupled receptors T22B7.7 T22B7.7 Protein with moderate similarity to C. elegans F57F4.1 T22C1.1 T22C1.1 Protein containing a putative zinc finger in N-recognin domain, has low similarity to uncharacterized S. pombe Mlo2p, which may play a role in chromosome segregation T22C1.10 T22C1.10 Protein with weak similarity to rab3 GTPase-activating protein non-catalytic subunit 150 kDa (human RAB3-GAP150) T22C1.11 T22C1.11 Protein of unknown function T22C1.2 T22C1.2 Member of the globin family of oxygen transporters Globin T22C1.3 T22C1.3 Protein of unknown function, has weak similarity to uncharacterized human CDC91L1 cell division control protein T22C1.4 T22C1.4 Protein of unknown function T22C1.5 T22C1.5 Protein of unknown function T22C1.6 T22C1.6 Putative coiled-coil protein, has weak similarity to S. cerevisiae Uso1p, required for protein transport from ER to Golgi myosin T22C1.7 jp;T22C1.7 Junctophilin; member of the junctophilin family; component of the junctional membrane complexes that mediate physiological coupling between the plasma membrane and intracellular membrane channels found in excitable cells jph-1 encodes a junctophilin, a protein that belongs to a transmembrane family of proteins implicated in the formation of the junctional membrane complex that forms between the plasma membrane and the endoplasmic reticulum in excitable cells; this complex facilitates cross-talk between the cell surface and intracellular ionic channels; RNA interference of jph-1 results in a locomotion defect suggesting impaired body-wall muscle function; a jph-1 promoter-gfp fusion reporter is expressed in all muscle cells and certain neurons of the nerve ring. T22C1.8 T22C1.8 Member of the protein-tyrosine phosphatase family, which are involved in control of cell growth, proliferation, differentiation and transformation, has a region of low similarity to C. elegans F10G8.1, which is a putative tyrosine protein phosphatase tyrosine specific protein phosphatase T22C1.9 T22C1.9 Protein of unknown function T22C8.1 T22C8.1 Protein of unknown function T22C8.2 T22C8.2 Member of the hyaluronidase family of glycosyl hydrolases, which hydrolyze glycosidic bonds, has low similarity to hyaluronidase 1 (mouse Hyal1), which degrades hyaluronan hyaluronidase T22C8.3 T22C8.3 Protein containing two C2H2 type zinc finger domains, which bind nucleic acids, has moderate similarity to uncharacterized C. elegans T22C8.4 Zinc finger, C2H2 type T22C8.4 T22C8.4 Protein containing two C2H2 type zinc finger domains, which bind nucleic acids, has moderate similarity to uncharacterized C. elegans T22C8.3 Zinc finger, C2H2 type T22C8.5 T22C8.5 Protein containing three C2H2 type zinc finger domains, which bind nucleic acids, has high similarity to a region of trans-acting transcription factor 1 (mouse Sp1), which is a transcriptional activator involved in stress response Zinc finger, C2H2 type (3 domains) T22C8.6 T22C8.6 Protein of unknown function, has strong similarity to C. elegans E04F6.6 T22C8.7 T22C8.7 Putative cuticulin, has strong similarity to C. elegans CUT-1 and T04F8.4 cuticulin T22C8.8 T22C8.8 Protein of unknown function vab-9 encodes a claudin homolog orthologous to human brain cell membrane protein 1 (BCMP1) and Drosophila CG6982; VAB-9 colocalizes with HMP-1 to an apical layer of the adherens junctions of all epithelial cells, one layer more apically than AJM-1; vab-9 mutants have disorganized F-actin at the adherens junction, implying that VAB-9 links junctions to circumferential actin filaments; VAB-9 is also expressed in the nerve ring; VAB-9 requires the cadherin HMR-1 to localize to the cell membrane, and both alpha-catenin (HMP-1) and beta-catenin (HMP-2) to remain at the cell junction after membrane localization. T22D1.1 T22D1.1 Protein containing a DUF23 domain of unknown function, has high similarity to uncharacterized C. elegans C13A2.6 T22D1.10 T22D1.10 Member of a protein family T22D1.11 T22D1.11 Member of the carboxylesterase type B family, has low similarity to esterase 1 (mouse Es1), which catalyzes hydrolysis of a variety of esters including fatty acid esters of estradiol carboxyesterase T22D1.12 T22D1.12 Member of the rhodopsin family of G-protein coupled receptors (GPCR), has low similarity to pancreatic polypeptide receptor Y4 (human PPYR1), which is a neuropeptide Y receptor that inhibits adenylyl cyclase and stimulates intracellular calcium flux seven transmembrane receptor T22D1.2 T22D1.2 Protein of unknown function, has moderate similarity to a region of carboxyl ester lipase (human CEL), which hydrolyzes cholesterol and other dietary esters and is involved in the intestinal absorption of dietary lipids and fat soluble vitamins T22D1.3 T22D1.3 Protein with high similarity to inosine monophosphate dehydrogenase type 2 (human IMPDH2), which catalyzes inosine monophosphate oxidation, contains four CBS (cystathionine-beta-synthase) and two IMP dehydrogenase or GMP reductase N and C terminus domains inosine monophosphate dehydrogenase T22D1.4 T22D1.4 Protein with moderate similarity to ribophorin I (human RPN1), which is a putative subunit of oligosaccharyltransferase involved in transcription initiation and possibly protein retention in the endoplasmic reticulum glycotransferase T22D1.5 T22D1.5 Protein with moderate similarity to C. elegans C06G1.5 gene product T22D1.6 T22D1.6 Protein of unknown function, has moderate similarity to C. elegans T22D1.7 T22D1.7 T05A12.4;T22D1.7 Protein containing an SNF2 related N-terminal domain, a helicase conserved C-terminal domain, and a C3HC4 type (RING) zinc finger, has a region of weak similarity to a region of mouse Smarca3, which is a transcriptional activator and ATPase T22D1.8 T22D1.8 Protein of unknown function T22D1.9 rpn-1;T22D1.9 Putative non-ATPase component of the 19S particle of the 26S proteasome complex rpn-1 encodes a non-ATPase subunit of the 26S proteasome's 19S regulatory particle (RP) base subcomplex; RPN-1 is required for embryonic, larval, and germline development and by homology, is predicted to function in unfolding and recognition of protein substrates and/or recycling of ubiquitin moieties during protein degradation. T22D2.1 T22D2.1 Protein containing four ankyrin (Ank) repeats, has a region of low similarity to a region of ankyrin 1 (mouse Ank1), which is a cytoskeletal anchor protein that attaches cytoskeletal elements to the plasma membrane T22E5.1 T22E5.1 Protein of unknown function T22E5.2 T22E5.2 Protein with high similarity to excitatory amino acid transporter 1 (human SLC1A3), which is a high affinity glutamate-aspartate transporter important for glutamate reuptake in excitatory neurotransmissions sodium-dependent glutamate/aspartate transporter; glt-4 encodes an ortholog of glutamate/aspartate and neutral amino acid transporters. T22E5.3 T22E5.3 Protein containing a fibronectin type III domain, which are involved in cell surface binding, and a DB module domain T22E5.5 mup-2;T22E5.5;TnT Troponin T, putative paralog of C. elegans F53A9.10 protein troponin T-like protein; mup-2 encodes the muscle contractile protein troponin T ( TnT ) homologous to vertebrate and invertebrate TnT and contains an invertebrate- specific COOH -terminal tail; mup-2 affects embryonic body wall muscle cell contraction, sarcomere organization, cell positioning, regulated muscle contraction in larval and adult body wall muscle, epidermal morphogenesis, and is required for proper function of the hermaphrodite nonstriated oviduct myoepithelial sheath, proper growth, and fertility. T22E5.6 T22E5.6 Protein of unknown function T22E7.1 T22E7.1 Protein containing five leucine rich repeats, which mediate protein-protein interactions T22E7.2 T22E7.2 Protein containing a DHHC-type zinc finger (NEW1) domain, has a region of low similarity to a region of S. cerevisiae Psl10p, which is an ER integral membrane protein involved in protein palmitoylation T22F3.10 T22F3.10 Protein of unknown function, has low similarity to a region of solute carrier family 17 member 1 (human SLC17A1), which is involved in sodium-dependent phosphate transport and mediates organic anion transport at the renal apical membrane T22F3.11 T22F3.11 Member of the sugar (and other) transporter family, has weak similarity to solute carrier family 17 member 1 (human SLC17A1), which is involved in sodium-dependent phosphate transport and mediates organic anion transport at the renal apical membrane T22F3.2 T22F3.2 Member of the ubiquitin carboxyl-terminal hydrolase family 2, which are cysteine proteases involved in deubiquination, has weak similarity to a region of ubiquitin C-terminal hydrolase (S. cerevisiae Ubp10p), which is involved in telomeric silencing T22F3.3 T22F3.3 Protein with high similarity to muscle glycogen phosphorylase (mouse Pygm), which catalyzes the catabolism of glycogen, member of the carbohydrate phosphorylase family, which catalyze the formation of phosphorylated glucose molecules T22F3.3 is orthologous to the human gene MUSCLE GLYCOGEN PHOSPHORYLASE (PYGM; OMIM:232600), which when mutated leads to McArdle disease. T22F3.4 T22F3.4 Protein with strong similarity to ribosomal protein L11 (human RPL11), which is a large 60S ribosomal structural protein that interacts with bleomycin hydrolase (human BLMH), member of the ribosomal L5 family, contains a ribosomal L5P C-terminal domain 60S ribososmal protein L11; rpl-11.1 encodes a large ribosomal subunit L11 protein. T22F3.5 T22F3.5 Member of the 7-transmembrane chemoreceptor family of G-protein coupled receptors (GPCR), has high similarity to uncharacterized C. elegans T22F3.6 7TM chemoreceptor, srh family T22F3.6 T22F3.6 Member of the 7-transmembrane chemoreceptor family of G-protein coupled receptors (GPCR), has high similarity to uncharacterized C. elegans T22F3.5 7TM chemoreceptor, srh family T22F3.7 T22F3.7 Member of the sugar (and other) transporter family, has weak similarity to solute carrier family 17 member 1 (human SLC17A1), which is involved in sodium-dependent phosphate transport and mediates organic anion transport at the renal apical membrane T22F3.8 T22F3.8 Member of the sugar (and other) transporter family, has weak similarity to solute carrier family 17 member 1 (mouse Slc17a1), which is involved in sodium-dependent phosphate transport and mediates hepatic and renal anion drug transport T22F7.1 T22F7.1 Member of the sugar (and other) transporter family, has weak similarity to solute carrier family 22 member 2 (rat Slc22a2), which may play a role in the transport of cationic drugs in the kidney T22F7.3 T22F7.3 Protein containing ten kunitz or bovine pancreatic trypsin inhibitor domains and four EB module domains, has a region of low similarity to tissue factor pathway inhibitor (human TFPI), which is a protease inhibitor that inhibits fibrin clot formation T22F7.4 T22F7.4 Protein with strong similarity to C. elegans K02D3.1 gene product transposase T22F7.5 T22F7.5 Protein with strong similarity to C. elegans ZC84.1 gene product T22G5.1 T22G5.1 Member of an uncharacterized protein family T22G5.2 lbp-7;T22G5.2 Protein with high similarity to C. elegans LBP-5, which is involved in locomotory behavior, member of the lipocalin and cytosolic fatty-acid binding protein family fatty-acid binding protein; lbp-7 encodes a predicted intracellular fatty acid binding protein (iFABP) that is most similar to the vertebrate muscle and heart FABPs; by homology, LBP-7 is predicted to function as an intracellular transporter for small hydrophobic molecules such as lipids and steroid hormones; as loss of lbp-7 activity via large-scale RNAi screens does not result in any obvious abnormalities, the precise role of LBP-7 in C. elegans development and/or behavior is not yet known. T22G5.3 T22G5.3 Protein containing an F-box domain, which serve as a link between a target protein and a ubiquitin-conjugating enzyme This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins. T22G5.4 T22G5.4 Protein of unknown function, has high similarity to uncharacterized C. elegans R03H4.7 7 transmembrane receptor (rhodopsin family) T22G5.5 T22G5.5 Protein with high similarity to serine palmitoyltransferase long chain base subunit 2 (human SPTLC2), which catalyzes the first step in ceramide biosynthesis, contains an aminotransferase class I and II domain serine palmitoyltransferase; This gene encodes a protein predicted by Eisenberg and coworkers, with 68% accuracy, to be mitochondrial. T22G5.6 lbp-8;T22G5.6 Member of the lipocalin and cytosolic fatty-acid binding protein family, has high similarity to a region of C. elegans LBP-5, which is involved in locomotory behavior retinol binding protein T22G5.7 T22G5.7 Protein with weak similarity to C. elegans T07C4.4 (Protein with similarity to bactericidal amoebapores that may act as an antibacterial agent) T22H2.1 T22H2.1 Member of the 7-transmembrane chemoreceptor family of G-protein coupled receptors (GPCR), has high similarity to uncharacterized C. elegans C54E10.4 7TM chemoreceptor, sri family T22H2.2 T22H2.2 Protein containing two DUF33 domains of unknown function, has high similarity to uncharacterized C. elegans F35E2.7 T22H2.3 T22H2.3 Member of the 7-transmembrane chemoreceptor family of G-protein coupled receptors (GPCR), has high similarity to uncharacterized C. elegans T22H2.1 7TM chemoreceptor, sri family T22H2.4 T22H2.4 Protein of unknown function, has weak similarity to C. elegans T12C9.3 T22H2.5 T22H2.5 Protein with moderate similarity to plasma membrane phospholipid scramblase 1 (human PLSCR1), which mediates Ca2+-dependent movement of membrane phospholipids in activated, injured, or apoptotic cells and may play a role in the DNA damage response T22H2.5 encodes a homolog of human scramblase (PLSCR1; OMIM:604170), which is activated by a rise of intracellular calcium, and which promotes the exposure of phosphatidylserine on the surface of cells undergoing activation, injury, or apoptosis; closely related paralogs of T22H2.5 include C04E12.7 and ZK1053.5. T22H2.6 T22H2.6 Protein containing five granulin domains, which are rich in cysteine residues, has a region of moderate similarity to a region of granulin (human GRN), which is a cysteine-rich putative growth factor with pleiotropic effects on epithelial cell growth granulin precursor T22H6.1 T22H6.1 Protein with strong similarity to C. elegans C44B12.6 gene product T22H6.2 T22H6.2 Putative ortholog of C. elegans T22H6.2 gene product 1-pyroline-5-carboxylate synthetase T22H6.3 T22H6.3 Member of the 7-transmembrane chemoreceptor family of G-protein coupled receptors (GPCR), has low similarity to C. elegans ODR-10, which is a G protein-coupled receptor involved in odorant response T22H6.4 T22H6.4 Member of the 7-transmembrane chemoreceptor family of G-protein coupled receptors (GPCR), has low similarity to C. elegans ODR-10, which is a G protein-coupled receptor involved in odorant response T22H6.5 T22H6.5 Protein of unknown function, has high similarity to uncharcterized C. elegans F54B8.5 The abf-5 gene encodes a homolog of the antibacterial factor ASABF from Ascaris suum. T22H6.6 T22H6.6 Protein containing a high mobility group box (HMG1 or 2) family domain, has a region of low similarity to a region of lymphoid enhancer-binding factor 1 (human LEF1), which is a transcriptional activator that also binds beta-catenin (human CTNNB1) HMG box transcription factor; gei-3 encodes a member of the high mobility group (HMG) protein family; interacts with GEX-3 in yeast two-hybrid assays. T22H9.1 T22H9.1 Protein of unknown function T22H9.2 T22H9.2 Protein of unknown function, has a region of low similarity to a region of S. cerevisiae Apg9p, which is required for starvation-induced autophagy T22H9.3 T22H9.3 Protein containing a piwi domain and a PAZ (Piwi, Argonaut and Zwille) domain, which may mediate protein-protein interactions, has a region of weak similarity to a region of C. elegans ALG-1, which plays a role in stRNA (small temporal RNA) production T22H9.4 T22H9.4 Protein with two DM DNA-binding domains T23B12.1 T23B12.1 Protein containing a PHD-finger, which may be involved in chromatin-mediated transcriptional regulation T23B12.10 T23B12.10 Protein with strong similarity to C. elegans ZK994.5 T23B12.2 T23B12.2 Member of the ribosomal L4 or L1 family, which are part of the large ribosomal subunit, has moderate similarity to uncharacterized mitochondrial ribosomal protein L4 (human MRPL4) ribosomal protein; This gene encodes a protein predicted by Eisenberg and coworkers, with 52% accuracy, to be mitochondrial. T23B12.3 T23B12.3 Similar to S. cerevisiae Mrp4p, part of the small subunit of the mitochondrial ribosome ribosomal protein; This gene encodes a protein predicted by Eisenberg and coworkers, with 68% accuracy, to be mitochondrial. T23B12.4 T23B12.4 Protein of unknown function T23B12.5 T23B12.5 Protein of unknown function, has weak similarity to C. elegans Y11D7A.9 T23B12.6 T23B12.6 Has high similarity to NY-REN-45 tumor antigen (human LOC51133), which is a tumor antigen, contains a K+ channel tetramerization domain, which facilitate assembly of alpha-subunits into functional tetrameric channels T23B12.7 T23B12.7 Protein containing a DnaJ domain, which are part of a chaperone (protein folding) system that mediates interaction with heat shock proteins, has a region of high similarity to a region of DnaJ homolog subfamily B member 4 (Hsp40, human DNAJB4) This gene encodes a protein containing a DnaJ ('J') domain that is predicted to be mitochondrial. T23B12.8 T23B12.8 Protein of unknown function T23B12.9 T23B12.9 Protein containing a retroviral integrase core domain, which are the central catalytic domains that can act as endonucleases, has high similarity to uncharacterized C. elegans F07C7.1 T23B3.1 T23B3.1 Protein of unknown function T23B3.2 T23B3.2 Member of the uncharacterized protein family UPF0057 T23B3.3 T23B3.3 Putative ortholog of C. elegans R13H9.1 gene product T23B3.4 T23B3.4 Member of the rhodopsin family of G-protein coupled receptors (GPCR), has low similarity to cholecystokinin A receptor (rat Cckar), which is a G protein-coupled receptor that activates phospholipase C and regulates dopamine signaling G-protein coupled receptor T23B3.5 T23B3.5 Protein with similarity to S. cerevisiae nuclear pore protein NSP1, has weak similarity to C. elegans K08H10.2 T23B3.6 T23B3.6 Protein of unknown function T23B5.1 T23B5.1 Protein with strong similarity to C. elegans JC8.11 gene product T23B5.3 T23B5.3 Putative ortholog of C. elegans C27D8.5 gene product T23B7.1 T23B7.1 Protein of unknown function T23C6.1 T23C6.1 Protein of unknown function, has strong similarity to C. elegans Y71F9B_271.A T23C6.3 T23C6.3 Putative ortholog of C. elegans K09E3.7 gene product T23C6.4 T23C6.4 Protein of unknown function T23C6.5 T23C6.5 Member of the rhodopsin family of G-protein coupled receptors (GPCR), has low similarity to bombesin receptor subtype 3 (human BRS3), which is a G protein-coupled receptor that activates phospholipase C and increases intracellular calcium ion levels G-protein coupled receptor T23D5.1 T23D5.1 Member of the 7-transmembrane chemoreceptor family of G-protein coupled receptors (GPCR), has low similarity to C. elegans ODR-10, which is a G protein-coupled receptor involved in odorant response 7TM receptor T23D5.10 T23D5.10 Member of the 7-transmembrane chemoreceptor family of G-protein coupled receptors (GPCR), has very strong similarity to uncharacterized C. elegans T23D5.12 7TM receptor T23D5.11 T23D5.11 Member of the 7-transmembrane chemoreceptor family of G-protein coupled receptors (GPCR), has strong similarity to uncharacterized C. elegans F57A10.1 7TM receptor T23D5.12 T23D5.12 Member of the 7-transmembrane chemoreceptor family of G-protein coupled receptors (GPCR), has weak similarity to C. elegans odr-10p, which [...] is involved in odorant response 7TM receptor T23D5.2 T23D5.2 Member of the 7-transmembrane chemoreceptor family of G-protein coupled receptors (GPCR), has moderate similarity to uncharacterized C. elegans C24B9.1 7TM receptor T23D5.3 T23D5.3 Protein with strong similarity to C. elegans Y68A4A.10 gene product T23D5.6 T23D5.6 Member of the 7-transmembrane chemoreceptor family of G-protein coupled receptors (GPCR), has low similarity to C. elegans ODR-10, which is G protein-coupled receptor involved in odorant response 7TM receptor T23D5.7 T23D5.7 Member of the 7-transmembrane chemoreceptor family of G-protein coupled receptors (GPCR), has low similarity to C. elegans ODR-10, which is a G protein-coupled receptor involved in odorant response 7TM receptor T23D5.8 T23D5.8 Putative ortholog of C. elegans T23D5.11 gene product 7TM receptor T23D5.9 T23D5.9 Member of the 7-transmembrane chemoreceptor family of G-protein coupled receptors (GPCR), has weak similarity to C. elegans ODR-10, which is a G protein-coupled receptor involved in odorant response 7TM receptor T23D8.1 mom-5;T23D8.1 Member of the frizzled family of receptors, regulates polarity of the EMS blastomere Drosophila tissue polarity protein like T23D8.2 T23D8.2 Member of the tetraspanin family, has low similarity to melanoma 1 antigen (human CD63), which forms complexes with beta 1 integrins, associates with peptide-loaded MHC class II molecules, and acts to limit the invasion and progression of melanoma tetraspanin T23D8.3 T23D8.3 Protein of unknown function T23D8.4 T23D8.4 Putative translation initiation factor 3, putative ortholog of H. sapiens EIF3S8 gene product [translation initiation factor 3] T23D8.5 T23D8.5 Member of the histone H4 protein family histone H4; his-67 encodes an H4 histone required for embryonic viability and growth. T23D8.6 T23D8.6 Member of the histone H2A protein family histone H2A; his-68 encodes an H2A histone. T23D8.7 T23D8.7 Protein containing a piwi domain, and a PAZ (Piwi, Argonaut and Zwille) domain, which may mediate protein-protein interactions, has moderate similarity to C. elegans ALG-1, which is involved in the production of stRNA (small temporal RNA) T23D8.8 T23D8.8 Protein containing an ARID (AT-Rich Interaction Domain) DNA binding domain, has moderate similarity to a region of B cell regulator of IgH transcription (mouse Dri1), which is a transcription factor involved in immunoglobulin production ARID DNA-binding protein; cfi-1 encodes a DNA-binding protein containing an AT-rich interaction domain (ARID) that affects differentiation of the URA sensory neurons, AVD, and PVC interneurons; acts downstream of UNC-86 and LIN-32 in controlling URA and IL2 cell fate, and is expressed in some neurons and muscle cells. T23D8.9 T23D8.9 Protein of unknown function T23E1.1 T23E1.1 Member of uncharacterized DUF229 family T23E1.2 T23E1.2 Protein of unknown function, has high similarity to uncharacterized C. elegans Y67D8C.3 T23E7.1 T23E7.1 Member of the reverse trancriptase family, which are RNA-dependent DNA polymerases, contains a retroviral integrase core domain and a zinc knuckle domain, has high similarity to uncharacterized C. elegans T03F1.4 T23E7.2 T23E7.2 Protein of unknown function, has a region of low similarity to a region of heavy polypeptide of neurofilament (mouse Nfh), which is a structural protein that may regulate axonal caliber, synaptic transmission, and type IV intermediate filament assembly T23E7.3 T23E7.3 Protein of unknown function, has high similarity to uncharacterized C. elegans K03F8.1 T23E7.4 T23E7.4 MGL/Famide neurotransmitter T23F1.1 T23F1.1 Member of the 7-transmembrane chemoreceptor family of G-protein coupled receptors (GPCR), has high similarity to uncharacterized C. elegans T26H5.3 T23F1.3 T23F1.3 Member of the 7-transmembrane chemoreceptor family of G-protein coupled receptors (GPCR), has weak similarity to C. elegans ODR-10, which is a G protein-coupled receptor involved in the odorant response T23F1.4 T23F1.4 Member of the 7-transmembrane chemoreceptor family of G-protein coupled receptors (GPCR), has weak similarity to C. elegans ODR-10, which is a G protein-coupled receptor involved in the odorant response T23F1.5 T23F1.5 Protein with moderate similarity to C. elegans ZK265.8 gene product T23F1.6 T23F1.6 Protein containing seven uncharacterized DUF139 cysteine repeat domains, has moderate similarity to uncharacterized C. elegans Y73F8A.9 The protein product of this gene is predicted to contain a glutamine/asparagine (Q/N)-rich ('prion') domain, by the algorithm of Michelitsch and Weissman (as of the WS77 release of WormBase, i.e., in wormpep77). T23F1.7 T23F1.7;T23F1.7;T23F1.7 Member of the prolyl oligopeptidase family, contains two dipeptidyl peptidase IV N-terminal domains, has low similarity to dipeptidylpeptidase IV (rat Dpp4), which is a serine type peptidase that removes dipeptides from regulatory peptides dipeptidyl peptidase IV T23F11.1 T23F11.1 Protein with high similarity to S. pombe Ptc3p, which is a serine/threonine phosphatase that plays a role in osmoregulation, member of the protein phosphatase 2C family, which are Mg2+ dependent protein serine and threonine phosphatases phosphatase T23F11.2 T23F11.2 Protein of unknown function, has strong similarity to uncharacterized C. elegans R07E5.15 T23F11.3 T23F11.3 Protein of unknown function, has a region of moderate similarity to a region of cyclin-dependent kinase 5 regulatory subunit 1 (human CDK5R1), which is a non-cyclin regulatory subunit for human CDK5 that is associated with Alzheimer's disease T23F11.4 T23F11.4 Protein with weak similarity to C. elegans T09F3.1 Zinc finger protein (C2H2 type) T23F11.5 srg-13;T23F11.5 G protein-coupled receptor, probably involved in chemosensation by sensory amphid neurons, no homolog found in human or D. melanogaster 7tm receptor T23F2.1 T23F2.1 Member of the glycosyl transferases group 1 family, which transfer nucleotide-linked sugars to acceptor substrates, has low similarity to S. cerevisiae Alg2p, which is a mannosyltransferase involved in N-glycosylation glycosyltransferase T23F2.2 T23F2.2 Putative coiled-coil protein, has weak similarity to S. cerevisiae Uso1p, required for protein transport from ER to Golgi T23F2.3 T23F2.3 Member of the uncharacterized protein family UPF005, has strong similarity to uncharacterized C. elegans T23F2.5 blt101 protein-barley T23F2.4 T23F2.4 Member of the uncharacterized protein family UPF0057, has high similarity to uncharacterized C. elegans T23F2.3 T23F2.5 T23F2.5 Member of the uncharacterized protein family UPF0057, has strong similarity to uncharacterized C. elegans T23F2.3 T23F4.1 T23F4.1 Member of the dienelactone hydrolase family, has high similarity to uncharacterized C. elegans T23F4.3 T23F4.2 T23F4.2 Protein of unknown function T23F4.3 T23F4.3 Member of the dienelactone hydrolase family, has high similarity to uncharacterized C. elegans T23F4.1 T23F4.4 T23F4.4 Member of the astacin (M12A) family of metalloproteases, has low similarity to a region of C. elegans HCH-1, which is a putative zinc-dependent metalloprotease involved in cell migration and neurogenesis protease T23F6.1 T23F6.1 Protein of unknown function T23F6.2 T23F6.2 Protein of unknown function, has strong similarity to uncharacterized C. elegans C17F4.3 T23F6.3 T23F6.3 Protein of unknown function, has weak similarity to C. elegans T24D1.2 T23F6.4 T23F6.4 Protein containing six RNA recognition motifs (RRM, RBD, or RNP), has weak similarity to S. cerevisiae Nop4p, which is a nucleolar protein required for ribosome biogenesis RNA recognition motif. (aka RRM, RBD, or RNP domain) (6 domains) T23F6.5 T23F6.5 Protein of unknown function T23G11.1 T23G11.1 Protein of unknown function, has weak similarity to C. elegans K09G1.2 T23G11.2 T23G11.2 Member of the phosphoglucosamine acetyltransferase protein family Acetyltransferase (GNAT) family (2 domains); gna-2 encodes a member of the phosphoglucosamine acetyltransferase protein family that affects cytokinesis, embryonic viability, and fertility. T23G11.3 gld-1;T23G11.3 RNA binding protein, required for transition from mitosis to meiosis during spermatogenesis and oogenesis in hermaphrodites female germline-specific tumor suppressor; gld-1 encodes a protein containing a K homology RNA binding domain that is required for meiotic cell cycle progression during oogenesis in parallel with gld-2, and also affects spermatogenesis; it physically interacts with its putative mRNA targets in vitro and with FOG-2, and is expressed in the cytoplasm at high levels during meiotic prophase. T23G11.4 T23G11.4 Protein of unknown function T23G11.5 T23G11.5 Protein containing a RhoGAP (GTPase activator protein) domain, has weak similarity to a region of ral-interacting protein 1 (mouse Rip1), which interacts with the activated form of Ral GTP binding protein and activates GTPases Rac1 and Cdc42 T23G11.6 T23G11.6 Protein containing eleven leucine rich repeats, which mediate protein-protein interactions, has low similarity to C. elegans SYM-1, which is required for attachment of body muscle to cuticle in the absence of MEC-8 Rat insulin-like growth factor binding protein complex acid labile chain like T23G11.7 T23G11.7 Protein of unknown function, has moderate similarity to uncharacterized C. elegans Y34B4A.2 T23G11.9 T23G11.9 Protein with similarity to Rho GTPase-activating proteins (RhoGAPs) T23G4.1 tlp-1;T23G4.1 Apparent zinc finger protein; more abundant in adult males than hermaphrodites The tlp-1 gene encodes a C2H2-type zinc finger of the Sp-1-like protein family, which is required for normal asymmetry in the divisions of the T.p and T.ap cells; such asymmetry, in turn, is required for normal, rounded tail morphology in adult males. | The tlp-1 gene encodes a C2H2-type zinc finger of the Sp-1-like protein family, which is required for normal asymmetry in the divisions of the T. T23G4.2 T23G4.2 Protein of unknown function, has weak similarity to C. elegans ZK930.6 T23G4.3 T23G4.3 Protein of unknown function, has high similarity to uncharacterized C. elegans Y87G2A.7 T23G4.4 T23G4.4 Protein containing a DUF33 domain of unknown function, has high similarity to uncharacterized C. elegans K09E10.2 T23G4.5 T23G4.5 Protein containing a DUF148 domain of unknown function, has high similarity to uncharacterized C. elegans T05E11.8 T23G5.1 T23G5.1 Member of the ribonucleotide reductase large subunit protein family Ribonucleoside-disphosphate reductase large chain T23G5.2 T23G5.2 Protein containing a CRAL-TRIO domain, has a region of low similarity to SEC14-like 2 (tocopherol-associated protein, human SEC14L2), which is an alpha-tocopherol-binding protein that activates transcription in an alpha-tocopherol-dependent manner SEC14 (yeast) T23G5.3 T23G5.3 Protein of unknown function T23G5.5 dat-1;CeDAT;T23G5.5 Dopamine transporter sodium:neurotransmitter symporter; dat-1 is orthologous to the human gene NOREPINEPHRINE TRANSPORTER (SLC6A2; OMIM:163970), which when mutated leads to disease. T23G5.6 T23G5.6 Protein containing an AT-hook motif, which bind DNA with a preference for A-T rich regions T23G7.1 dpl-1;T23G7.1 Transcription factor; strongly similar to D. melanogaster E2F-related transcription factor DP transcription factor DP-1; dpl-1 encodes a homolog of mammalian DP required for embryonic asymmetry. T23G7.2 T23G7.2 Protein of unknown function, has low similarity to uncharacterized C. elegans F40B5.2 T23G7.3 T23G7.3 Protein containing a G-patch domain, which are found in RNA processing proteins, has low similarity to uncharacterized pin2-TRF1-interacting protein (mouse Pinx1), which may bind and inhibit the telomerase catalytic subunit mouse Tert T23G7.4 sec-5;T23G7.4 Protein containing an IPT or TIG domain, which contain immunoglobulin-like folds, has low similarity to uncharacterized rat secretion 5 (rat Rsec5) The sec-5 gene encodes an ortholog of SEC5 in S. cerevisiae, a component of the exocyst complex required genetically for endocytosis and for normal cellular morphology in the intestine. T23G7.5 T23G7.5 Protein containing a dual specificity phosphatase catalytic domain, has moderate similarity to a region of dual specificity phosphatase 11 (human DUSP11), which is a nuclear dual specificity phosphatase associated with RNA and ribonucleoprotein complexes tyrosine specific protein phosphatase T23H2.1 T23H2.1 Protein containing a bacterial Ig-like domain (group 2), which are found in bacterial and phage surface proteins, has low similarity to uncharacterized nuclear pore membrane glycoprotein (rat Nup210), which is a component of the nuclear pore complex integral membrane protein; npp-12 encodes Gp210, an evolutionarily conserved membrane protein of the nuclear pore complex (NPC); NPP-12 is required for embryonic viability and normal nuclear membrane structures. T23H2.2 T23H2.2 Protein containing two C2 domains, has moderate similarity to synaptotagmin 4 (rat Syt4), which regulates the kinetics of fusion pore opening during neurotransmitter release and serves in brain development and synaptic plasticity C2 domain protein T23H2.3 T23H2.3 Putative ortholog of human HuF2/TTF2, a RNA polymerase II termination factor helicase T23H2.4 T23H2.4 Protein of unknown function T23H2.5 T23H2.5 Protein with high similarity to A. niger SrgA, which is a putative GTPase with a role in secretion, member of the Ras superfamily of GTP binding proteins RAS T23H4.1 T23H4.1 Member of the integral membrane innexin family, which are involved in the formation of gap junctions, has moderate similarity to C. elegans UNC-9, which is required for normal locomotion Ogre family (2 domains) T23H4.2 nhr-69;T23H4.2 Protein containing nuclear hormone receptor ligand-binding and C4-type zinc finger domains, has moderate similarity to hepatocyte nuclear factor 4 gamma (mouse Hnf4g), which is a transcriptional activator Ligand-binding domain of nuclear hormone receptors, Zinc finger, C4 type (two domains); nhr-69 encodes a conserved nuclear receptor that is a member of the NR2 subfamily of nuclear receptors that contains Drosophila and human HNF4 (OMIM:600281, mutations in human HNF4A are associated with Type I MODY (maturity-onset diabetes of the young)); by homology, NHR-69 is predicted to function as a transcription factor that may activate or repress transcription in response to a hormonal signal; however, as loss of nhr-69 activity via RNAi does not result in any obvious abnormalities, the precise role of NHR-69 in C. elegans development and/or behavior is not yet known; nhr-69 is expressed strongly in the gut and hypodermis at all stages and is detected in the uterus during the late L4 and adult stages; nhr-69 expression is also occasionally detected in the rectal epithelia and posterior pharynx. T23H4.3 T23H4.3 Member of the astacin (M12A) family of metalloproteases, has a region of low similarity to a region of Meprin A beta subunit (mouse Mep1b), which is a metalloendopeptidase that forms a meprin A heterodimer with an Meprin A alpha subunit (mouse Mep1a) zinc metalloprotease T24A11.1 T24A11.1 Member of the myotubularin protein family T24A11.2 T24A11.2 Protein of unknown function T24A11.3 toh-1;T24A11.3 Member of the zinc metalloprotease protein family zinc metalloprotease T24A11.4 T24A11.4 Protein of unknown function T24A6.1 T24A6.1 Protein with strong similarity to C. elegans ZK678.3 gene product T24A6.10 T24A6.10 Protein containing a DUF40 domain of unknown function, which contain four conserved cysteines, has high similarity to uncharacterized C. elegans T24A6.13 T24A6.11 T24A6.11 Protein containing nuclear hormone receptor C4-type zinc finger and ligand-binding domains, has low similarity to C. elegans NHR-51, which is a putative transcriptional activator involved in developmental processes zinc finger protein T24A6.12 T24A6.12 Protein containing two DUF40 domains of unknown function, which contain four conserved cysteines, has high similarity to uncharacterized C. elegans T24A6.13 T24A6.13 T24A6.13 Protein containing a DUF40 domain of unknown function, which contain four conserved cysteines, has high similarity to uncharacterized C. elegans T24A6.10 T24A6.14 T24A6.14 Protein of unknown function, has moderate similarity to uncharacterized C. elegans C44C3.3 7TM chemoreceptor, srw family T24A6.15 T24A6.15 Protein of unknown function containing a Ground-like domain, has strong similarity to C. elegans F40C5.F T24A6.16 T24A6.16 Protein of unknown function, has strong similarity to uncharacterized C. elegans F40C5.1 T24A6.17 T24A6.17 Protein with moderate similarity to C. elegans F40C5.2 gene product T24A6.18 T24A6.18 Protein of unknown function containing a Ground-like domain, has moderate similarity to C. elegans F40C5.F T24A6.19 T24A6.19 Protein with strong similarity to C. elegans F40C5.3 gene product T24A6.2 T24A6.2 Protein with strong similarity to C. elegans T07F10.2 gene product T24A6.20 T24A6.20 Putative ortholog of C. elegans C03G6.17 gene product T24A6.3 T24A6.3 Protein of unknown function containing a Ground-like domain, has moderate similarity to C. elegans F40C5.F T24A6.4 T24A6.4 Member of the 7-transmembrane chemoreceptor family of G-protein coupled receptors (GPCR), has low similarity to uncharacterized C. elegans B0454.4 7TM chemoreceptor, sri family T24A6.5 T24A6.5 Protein containing a DUF40 domain of unknown function, which contain four conserved cysteines, has high similarity to uncharacterized C. elegans Y39G10AR.22 T24A6.6 T24A6.6 Member of the 7-transmembrane chemoreceptor family of G-protein coupledreceptors (GPCR), has low similarity to C. elegans ODR-10, which is a G protein-coupled receptor involved in the odorant response 7TM chemoreceptor, str family T24A6.7 T24A6.7 Protein of unknown function, has high similarity to uncharacterized C. elegans C07G3.2 T24A6.8 T24A6.8 Protein containing nuclear hormone receptor C4-type zinc finger and ligand-binding domains, has weak similarity to pregnane X receptor (mouse Nr1i2), which is a steroid activated nuclear hormone receptor that activates cytochrome P450 gene transcription zinc finger protein T24A6.9 T24A6.9 Protein containing two nuclear hormone receptor C4-type zinc finger domains and two nuclear hormone receptor ligand-binding domains, has low similarity to a region of glucocorticoid receptor (rat Nr3c1), which is a hormone-dependent transcription factor T24B1.1 T24B1.1 Putative ortholog of C. elegans T23G11.8 gene product T24B1.1 is orthologous to the human gene GOLGI AUTOANTIGEN, GOLGIN SUBFAMILY A, 5 (GOLGA5; OMIM:606918), which when mutated leads to disease. T24B8.1 rpl-32;T24B8.1 Protein with high similarity to ribosomal protein L32 (human RPL32), which is an RNA-binding structural component of the large 60S ribosomal subunit, member of the ribosomal L32e family 60S ribosomal protein L32; rpl-32 encodes a large ribosomal subunit L32 protein. T24B8.2 T24B8.2 Protein with similarity over C-terminal half to S. cerevisiae Snf7p, a protein involved in glucose derepression and in pre-vacuolar protein sorting Yeast SNF7 like protein T24B8.3 T24B8.3 Protein with weak similarity to C. elegans Y113G7B.12 gene product T24B8.4 T24B8.4 Protein containing two Wiskott Aldrich syndrome homology region 2 (WH2) domains T24B8.5 T24B8.5 Protein of unknown function, has weak similarity to C. elegans F49F1.7 T24B8.6 hlh-3;T24B8.6 Protein containing a helix-loop-helix DNA-binding domain, which mediate protein dimerization helix-loop-helix protein; hlh-3 encodes a basic helix-loop-helix transcription factor homologous to Drosophila Achaete-scute; in vitro, HLH-3 can heterodimerize, and bind an E-box-containing probe, with HLH-2, the C. elegans E/daughterless ortholog with which it is coexpressed in the nuclei of embryonic neuronal precursors. T24B8.7 T24B8.7 Protein containing three UBA (ubiquitin associated) or TS-N domains, has a region of weak similarity to a region of ubiquitin specific protease 9 X chromosome (human USP9X), which is translated from a gene that escapes X inactivation T24C12.1 T24C12.1 Protein of unknown function T24C12.2 gap-1;T24C12.2 GTPase activating protein; inhibitor of LET-60 Ras GTPase activating protein (GAP); gap-1 encodes a member of the Ras GTPase-activating protein family; negatively regulates the let-60 pathway with respect to vulval development. T24C12.3 T24C12.3 Member of the PfkB family of carbohydrate kinases, has low similarity to uncharacterized S. pombe Spbc1861.05p T24C12.4 T24C12.4 Protein of unknown function, has moderate similarity to C. elegans M153.3 T24C2.1 ram-5;T24C2.1 Protein with weak similarity to C. elegans CUT-1 (Cuticulin component) and required for normal ray morphology of the male tail cuticlin like T24C2.2 T24C2.2 Protein of unknown function, has weak similarity to C. elegans F43C11_37.B and T01C3.9 T24C2.3 T24C2.3 Protein of unknown function T24C2.4 T24C2.4 Protein containing an F-box domain, which serve as a link between a target protein and a ubiquitin-conjugating enzyme, and a DUF38 domain of unknown function, has low similarity to C. elegans FOG-2, which is required for the sexual identity of germ cells This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins; this gene's encoded protein also contains an FTH/DUF38 motif, which may also mediate protein-protein interaction. T24C2.5 T24C2.5 Protein of unknown function T24C4.1 T24C4.1 Member of the insulinase (peptidase M16) family, which are divalent cation-dependent, has moderate similarity to uncharacterized C. elegans T10B10.2 Ubiquinol-cytochrome C reductase complex core protein 2; This gene encodes a protein predicted by Eisenberg and coworkers, with 68% accuracy, to be mitochondrial. T24C4.2 T24C4.2 Protein of unknown function T24C4.3 T24C4.3 Protein of unknown function, has weak similarity to C. elegans C18A11.1 T24C4.4 T24C4.4 Protein of unknown function, has weak similarity to C. elegans F10A3.1 T24C4.5 T24C4.5 Member of the DNA primase subunit (tentative) protein family T24C4.6 T24C4.6 Protein of unknown function, has a region of weak similarity to C. elegans ZYG-11, which is required for zygote formation T24C4.7 T24C4.7 Protein containing a C2H2 type zinc finger domain, which bind nucleic acids, and a retroviral integrase core domain, which are the central catalytic domains that can act as endonucleases T24D1.1 T24D1.1 Protein of unknown function, has moderate similarity to uncharacterized human CHSY1 sqv-5 encodes a chondroitin synthase that both initiates and elongates chondroitin chains (unlike human chondroitin synthase, which only elongates them); SQV-5 is required for cytokinesis (e.g., at the one-cell embryo stage), gonad migration, and vulval morphogenesis (by expanding the extracellular space of the vulva in L4 larvae); the common requirement for SQV-5 in both processes may be to promote filling an extracellular space with fluid (either in the eggshell, or underneath the L4 cuticle); SQV-5 colocalizes with SQV-1 at punctate foci (probably the Golgi apparatus) in the cytoplasm of the vulva, the uterus and oocytes; SQV-5 is most similar to human chondroitin synthase (KIAA0990) and Drosophila CG9220. T24D1.2 T24D1.2 Protein with two RING-type (C3HC4 ) zinc finger domains, has similarity to C. elegans T24D1.3 Zinc finger, C3HC4 type (RING finger) (2 domains) T24D1.3 T24D1.3 Protein with strong similarity to C. elegans T24D1.2 gene product T24D1.4 T24D1.4 Protein with low similarity to potassium channel regulator 1 (rat KCR1), which functions as a regulatory component of non-inactivating potassium channels Yeast DIE2 protein like T24D1.5 T24D1.5 Putative ortholog of C. elegans T24D1.2 gene product T24D11.1 T24D11.1 Protein containing a TBC domain, which may be GTPase activators of Rab-like small GTPases, has moderate similarity to a region of RAB6 GTPase activating protein (human GAPCENA, GAP and centrosome-associated), which plays a role in microtubule nucleation T24D3.1 T24D3.1 Protein with very strong similarity to C. elegans MED-1, which is a GATA-type transcription factor, contains a GATA-type zinc finger domain GLN3 like; The med-1 gene encodes a GATA-type transcription factor that is an immediate target of maternal SKN-1, and that participates in specifying the mesendoderm. T24D5.1 T24D5.1 Protein of unknown function, has moderate similarity to C. elegans T24D5.3 T24D5.2 T24D5.2 Protein of unknown function T24D5.3 T24D5.3 Protein of unknown function, has moderate similarity to C. elegans T24D5.1 T24D5.4 T24D5.4 Protein of unknown function, has moderate similarity to a region of large tumor suppressor 1 (mouse Lats1), which is a putative protein kinase that regulates cell proliferation and the cell cycle and inhibits tumor growth protein kinase like T24D5.5 T24D5.5 Protein of unknown function, putative paralog of C. elegans R09A8.1 T24D8.1 T24D8.1 Protein containing neurotransmitter-gated ion-channel ligand binding and transmembrane domains, has low similarity to C. elegans AVR-14, which is a glutamate gated ion channel involved in drug resistance gamma-aminobutyric-acid receptor T24D8.2 T24D8.2 Protein of unknown function T24D8.3 T24D8.3 FRPamide neurotransmitter T24D8.4 T24D8.4 FRPamide neurotransmitter nlp-23 encodes three predicted neuropeptide-like proteins; in C. elegans, nlp-23 is part of the FRPamide neuropeptide family that also contains nlp-2 and nlp-22; nlp-23 is expressed in the tail and in dorsal and ventral hypodermis; as loss of nlp-23 activity via large-scale RNAi screens does not result in any obvious abnormalities, the precise role of the nlp-23-encoded peptides in development and/or behavior is not yet known. T24D8.5 T24D8.5 FRPamide neurotransmitter T24D8.6 T24D8.6 Protein of unknown function T24E12.1 T24E12.1 Protein of unknown function, has weak similarity to C. elegans Y8A9A.E T24E12.10 T24E12.10 Protein with weak similarity to C. elegans unc-44 (Set of ankyrin-related proteins generated by alternate splicing, required for axonal guidance and proper axon fasciculation) T24E12.11 T24E12.11 Protein of unknown function T24E12.2 T24E12.2 Protein of unknown function, has weak similarity to C. elegans T24E12.1 T24E12.3 T24E12.3 Protein of unknown function T24E12.4 T24E12.4 Protein of unknown function, has moderate similarity to C. elegans F40H7.9 7TM chemoreceptor, srx family T24E12.5 T24E12.5 Protein of unknown function, has moderate similarity to C. elegans Y47G7B.2 T24E12.6 T24E12.6 Protein of unknown function T24E12.8 T24E12.8 Protein of unknown function, has strong similarity to C. elegans C46E10.6 7TM chemoreceptor, srx family T24E12.9 T24E12.9 Protein of unknown function, has weak similarity to C. elegans C36C9.5 T24F1.1 T24F1.1 Putative GTP-binding protein; possible ortholog of S. cerevisiae Gtr1p, which is involved in phosphate transport GTP-binding protein T24F1.2 T24F1.2 Protein of unknown function T24F1.3 T24F1.3 Protein containing a protein kinase C conserved region 1 (C1) domain and a Ras association (RalGDS/AF-6) domain, both of which are able to bind RasGTP DAG binding domain T24F1.4 T24F1.4 Protein with weak similarity to H. sapiens JAG1 (jagged1 (Alagille syndrome)) T24F1.5 T24F1.5 Protein of unknown function T24F1.6 T24F1.6 Putative calcium channel protein, has similarity to human CACNA2, voltage-dependent calcium channel, alpha 2/delta subunit calcium channel alpha-2 subunit T24G10.2 T24G10.2 Protein containing a BAF60b domain of the SWIB complex T24H10.1 T24H10.1 Protein with high similarity to transcription elongation factor A (SII) 1 (mouse Tcea1), which activates cleavage of transcripts by RNA polymerase II elongation complexes, member of the S-II (TFIIS) transcription factor family transcription factor S-II T24H10.2 T24H10.2 Protein containing a bZIP (basic-leucine zipper) transcription factor domain T24H10.3 T24H10.3 Protein containing a DnaJ domain, which are part of chaperone (protein folding) system that mediates interaction with heat shock proteins, has low similarity to S. pombe Spac1071.09cp, which is a DnaJ protein DNAJ protein; This gene encodes a protein containing a DnaJ ('J') domain. T24H10.4 T24H10.4 Protein of unknown function, has low similarity to uncharacterized C. elegans T10B11.6 T24H10.5 T24H10.5 Protein with moderate similarity to C. elegans C46C2.3 gene product T24H10.6 T24H10.6 Protein of unknown function, has high similarity to uncharacterized human DNLC2A bithoraxoid-like protein T24H10.7 T24H10.7 Protein of unknown function, has weak similarity to C. elegans Y51B11_80.A BZIP protein T24H5.1 T24H5.1 Putative ortholog of C. elegans F07C7.1 gene product T24H7.1 T24H7.1 Protein with high similarity to human REA (B-cell receptor-associated protein), which is a repressor of the estrogen-bound estrogen receptor activity that interacts with prohibitin (human PHB), member of the SPFH domain or Band 7 family Prohibitin T24H7.2 T24H7.2 Putative ER chaperone (GenBank), has strong similarity to H. sapeins ORP150 gene product [oxygen-regulated protein] T24H7.3 T24H7.3 Protein with strong similarity to C. elegans Y43F8B.M gene product T24H7.4 T24H7.4 Protein of unknown function T24H7.5 T24H7.5 Putative ortholog of S. cerevisiae Drs2p, a membrane-spanning Ca-ATPase (P-type) required for ribosome assembly ATPase T25B2.1 T25B2.1 Protein with strong similarity to C. elegans T13C5.2 gene product T25B2.2 T25B2.2 Protein of unknown function T25B6.1 T25B6.1 Protein of unknown function T25B6.2 T25B6.2 Member of the M13 peptidase family of zinc metalloproteases, has low similarity to endothelin-converting enzyme 1 (human ECE1), which is a zinc metalloprotease that generates endothelin vasoconstrictors and is associated with developmental defects zinc metalloprotease; T25B6.2 encodes two isoforms of a neprilysin; neprilysins are thermolysin-like zinc metallopeptidases, found on the outer surface of animal cells, that negatively regulate small signalling peptides (e.g., enkephalin, tachykinin, insulin, and natriuretic peptides) by cleaving them; T25B6.2 is orthologous to Ac-mep-1, a gut luminal neprilysin which is specifically expressed in the adult life stage of Ancylostoma caninum hookworms, and whose protein product is localized to the microvilli of the gastrointestinal tract, suggesting a role in digestion. T25B6.3 T25B6.3 Protein of unknown function, has moderate similarity to uncharacterized C. elegans C09H10.5 T25B6.4 T25B6.4 Protein of unknown function T25B6.5 T25B6.5 Protein of unknown function T25B6.6 T25B6.6 Protein of unknown function T25B6.7 T25B6.7 Putative transporter, has strong similarity to a number of transporters from C. elegans and humans sodium dependent neurotransporter T25B9.1 T25B9.1 Protein containing an aminotransferase class I and II domain, has low similarity to delta-aminolevulinate synthase (mouse Alas1), which may play a role in heme biosynthesis glycine C-acetyltransferase; T25B9.1 encodes an protein highly similar to 2-amino-3-keto-butyrate coenzyme A ligases (also called AKB ligases or glycine acetyltransferases; EC 2.3.1.29; R.W. T25B9.10 T25B9.10 Protein containing an inositol polyphosphate phosphatase catalytic domain, has low similarity to skeletal muscle and kidney-enriched inositol phosphatase (human SKIP), which is an inositol polyphosphate 5-phosphatase Yeast hypothetical protein YIA2 like T25B9.2 T25B9.2 Serine/threonine protein phosphatase serine/threonine protein phosphatase T25B9.3 T25B9.3 Protein of unknown function T25B9.4 T25B9.4 Protein containing a protein kinase domain and a Src homology 2 (SH2) domain, which are regulatory modules of intracellular signaling, has low similarity to fyn-related kinase (B-cell src-homology tyrosine kinase, mouse Frk), which is a protein kinase Src homology domain 2, protein tyrosine kinase (ABL subfamily) T25B9.5 T25B9.5 Protein containing a protein kinase domain and a Src homology 2 (SH2) domain, which are regulatory modules of intracellular signaling, has low similarity to csk homologous kinase (mouse Matk), which is a non-receptor protein tyrosine kinase Src homology domain 2, protein tyrosine kinase (ABL subfamily) T25B9.6 T25B9.6 Protein of unknown function, has moderate similarity to uncharacterized C. elegans C31H1.1 T25B9.7 T25B9.7 Member of the UDP-glucuronosyltransferase protein family UDP-glucuronosyltransferase T25B9.8 T25B9.8 Protein of unknown function lin-15a like protein T25B9.9 T25B9.9 Protein with high similarity to 6-phosphogluconate dehydrogenase (human PGD), which converts 6-phospho-D-gluconate to D-ribulose 5-phosphate in the pentose phosphate shunt and may associated with hemolytic anemia upon deficiency 6-phosphogluconate dehydrogenase T25C12.1 T25C12.1 Putative ortholog of C. elegans lin-14 gene product embryonic nuclear protein lin-14 form A T25C12.2 T25C12.2 Protein of unknown function, has a region of moderate similarity to a region of C. elegans T08A9.9, which is an antibacterial peptide T25C12.3 T25C12.3 Member of the EGF-repeat protein family, member of the C-type lectin family EGF-repeats T25C8.1 T25C8.1 Protein of unknown function T25C8.2 act-5;T25C8.2 Protein with strong similarity to gamma actin (mouse Actg), which is a dystrophin binding protein involved in the establishment and maintenance of cellular morphology and cytoarchitecture, member of the actin family Actins; an ortholog of human cytoplasmic actin; and is expressed only in microvillous intestinal cells and excretory cell. T25C8.3 T25C8.3 Protein with high similarity to glutamine synthase (rat Glul), which catalyzes the condensation of glutamate and ammonia to form glutamine and may clear L-glutamate from neuronal synapses, contains one glutamine synthetase domain T25D1.1 T25D1.1 Putative ortholog of C. elegans C36C9.4 gene product T25D1.2 T25D1.2 Putative ortholog of C. elegans C36C9.4 gene product T25D1.3 T25D1.3 Protein containing two GLTT repeat region domains and an F-box domain, which serve as a link between a target protein and a ubiquitin-conjugating enzyme cleavage stimulation factor; This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins. T25D10.1 T25D10.1 Protein containing a BTB (BR-C, ttk and babor) or POZ (Pox virus and zinc finger) domain, which are found in some DNA and actin binding proteins and may mediate protein-protein interactions T25D10.2 T25D10.2 Protein of unknown function T25D10.3 T25D10.3 Protein of unknown function, has a region of low similarity to a region of periaxin (rat Prx), which interacts with rat Drp2, may have a role in stabilization of the myelin sheath, and is expressed by myelinating Schwann cells T25D10.4 T25D10.4 Protein of unknown function T25D3.2 T25D3.2 Simlar to a protein of the mitochondrial large ribosomal subunit T25D3.3 T25D3.3 Member of the pyridoxal phosphate dependent enzyme beta family, has weak similarity to a region of cystathionine beta-synthase (beta-CTSase, S. cerevisiae Cys4p), which converts serine and homocysteine to cystathionine serine/threonine dehydratase; This gene encodes a protein predicted by Eisenberg and coworkers, with 68% accuracy, to be mitochondrial. T25D3.4 T25D3.4 Putative ortholog of C. elegans T25D3.1 gene product T25E12.10 T25E12.10 Member of the C-type lectin protein family Lectin C-type domain short and long forms (2 domains) T25E12.11 T25E12.11 Protein containing two DUF216 domains of unknown function and one DUF38 domain of unknown function, has weak similarity to uncharacterized C. elegans H12I19.1 DUF-216 family T25E12.4 T25E12.4 Protein with high similarity to mu isoform of protein kinase C (protein kinase D, human PRKCM), contains two phorbol ester or diacylglycerol binding domains (C1 domains), a pleckstrin homology (PH) domain, and a protein kinase domain Phorbol esters/diacylglycerol binding domain (C1 domain) (2 domains), serine/threonine kinase T25E12.5 T25E12.5 Putative glycogenin (self-glucosylating protein involved in glycogen biosynthesis), has strong similarity to human glycogenins GYG/Hs.174071 and Hs.58589 glycogenin T25E12.6 T25E12.6 Protein containing a DUF38 domain of unknown function T25E12.7 T25E12.7 Member of the C-type lectin protein family Lectin C-type domain short and long forms (2 domains) T25E12.8 T25E12.8 Member of the C-type lectin protein family C-type lectin T25E12.9 T25E12.9 Protein containing two C-type lectin domains, has a region of low similarity to regeneration protein (lithostatin, pancreatic stone protein, rat Reg1), which induces pancreatic beta cell regeneration and ameliorates diabetes Lectin C-type domain short and long forms (2 domains) T25E4.1 T25E4.1 Protein of unknown function, has high similarity to uncharacterized C. elegans MYO2-D T25E4.2 T25E4.2 Protein of unknown function, has weak similarity to C. elegans C08B6.5 Glutamate receptor T25F10.1 T25F10.1 Protein of unknown function T25F10.2 dbl-1;cet-1;T25F10.2 Ligand involved in body size regulation and male tail development; member of the Dpp paralog class of the BMP family of the TGF-beta superfamily TGF-beta-like growth factor; dbl-1 encodes a transforming growth factor beta (TGF beta) homologoue related to Drosophila decapentaplegic (dpp) and the vertebrate bone morphogenetic proteins (BMPs); DBL-1 functions, in a dose-dependent manner, as the ligand for a Smad signaling pathway that regulates body size morphogenesis and patterning of the male tail sensory rays and copulatory spicules; DBL-1 signaling positively regulates expression of SMA-6, which along with DAF-4, comprise the heteromeric DBL-1 receptor, and negatively regulates expression of LON-1, a predicted secreted protein and downstream component in the body size signaling pathway; DBL-1 is expressed primarily in neurons. T25F10.3 T25F10.3 Protein with putative EGF-like repeats, has weak similarity to members of the Notch protein family over the central region T25F10.4 T25F10.4 Protein of unknown function T25F10.5 T25F10.5 Protein containing seven TPR (tetratrico peptide repeat) domains, which may mediate protein-protein interactions T25F10.6 T25F10.6 Putative paralog of C. elegans UNC-87 which encodes muscle thin filament-associated protein calponin-like protein T25G12.1 T25G12.1 Protein of unknown function T25G12.2 T25G12.2 Member of the short-chain dehydrogenase-reductase family, which are NAD- or NADP-dependent oxidoreductases, has a region of low similarity to a region of 11-beta-hydroxysteroid dehydrogenase type 1 (human HSD11B1) dehydrogenase; The T25G12.2 gene encodes a homolog of the human gene HSD, which when mutated leads to cortisol 11-beta ketoreductase deficiency (OMIM:218030); T25G12.2 protein is predicted to be mitochondrial with 68% accuracy. T25G12.3 T25G12.3 Protein of unknown function T25G12.4 T25G12.4 Protein with strong similarity to ras-related GTP-binding protein 6 (human RAB6A), which is a GTPase involved in intracellular protein trafficking, protein secretion, and Golgi to ER transport, member of the Ras superfamily of GTP binding proteins ras-related protein; rab-6.2 encodes a small, monomeric Rab GTPase that is most closely related to the Drosophila Rab6 and mammalian Rab6a GTPases; by homology, RAB-6.2 is predicted to function as a membrane-associated GTPase required for intracellular vesicular trafficking and for regulation of endo- and exocytosis; however, as loss of rab-6.2 function via RNA-mediated interference (RNAi) does not result in any obvious abnormalities, the precise role of RAB-6.2 in C. elegans development and/or behavior is not yet known. T25G12.5 T25G12.5 Member of the acyl-CoA dehydrogenase protein family acyl-CoA dehydrogenase T25G12.6 T25G12.6 Protein of unknown function T25G12.7 T25G12.7 Putative dehydrogenase, has strong similarity to C. elegans T25G12.2 dehydrogenase; dhs-30 encodes a member of the short-chain dehydrogenases/reductases family (SDR) homologous to HSD, which when mutated leads to cortisol 11-beta ketoreductase deficiency (OMIM:218030). T25G12.8 T25G12.8 Protein of unknown function, has weak similarity to C. elegans C01A2.1 T25G12.9 T25G12.9 Protein with high similarity to C. elegans C01B12.6, which is a transposase, member of the transposase family, which are required for excising and inserting mobile genetic elements, contains a retroviral integrase core domain transposase T25G3.1 T25G3.1 Protein of unknown function T25G3.2 chi-1;T25G3.2 Protein with similarity to chitin synthases, probable paralog of C. elegans F48A11.1 chitin synthase like; chi-1 encodes a putative chitin synthase, most closely related to chitin synthases characterized in filarial nematodes. T25G3.3 T25G3.3 Putative ortholog of S. cerevisiae Nmd3p, which is required for stable 60S ribosomal subunit formation Yeast nonsense-mediated mRNA decay protein like T25G3.4 T25G3.4 Member of the glycerol-3-phosphate dehydrogenase, mitochondrial protein family mitochondrial glycerol-3-phosphate dehydrogenase; T25G3.4 is orthologous to the human gene GLYCEROL-3-PHOSPHATE DEHYDROGENASE 3 (GPD2; OMIM:138430), which when mutated leads to disease. T26A5.1 T26A5.1 Member of the ABC transporter family, which are involved in translocation of a variety of compounds across biological membranes, has low similarity to ATP-binding cassette subfamily G member 2 (breast cancer resistance protein, mouse Abcg2) This gene encodes a protein predicted by Eisenberg and coworkers, with 52% accuracy, to be mitochondrial. T26A5.2 T26A5.2 Protein of unknown function T26A5.3 T26A5.3 Protein that can function in place of mitochondrial Complex I NADH dehydrogenase GAS-1, but with very low/unknown expression NADH-ubiquinone oxidoreductase; This gene encodes a protein predicted by Eisenberg and coworkers, with 52% accuracy, to be mitochondrial. T26A5.4 T26A5.4 Protein with strong similarity to S. cerevisiae Alg1p, a beta-mannosyltransferase involved in protein N-glycosylation Beta-mannosyltransferase T26A5.5 T26A5.5 Protein containing two Jumonji (jmjC) domains, has weak similarity to uncharacterized PHD finger protein 2 (human PHF2), which is a putative transcription factor T26A5.6 T26A5.6 Protein of unknown function, has low similarity to uncharacterized S. pombe Spac23h3.14p T26A5.7 T26A5.7 Protein containing a SET domain, has a region of low similarity to a region of myeloid-lymphoid (or mixed-lineage) leukemia (human MLL), which is transcription factor acting in cell cycle regulation and differentiation and is implicated in acute leukemias T26A5.8 T26A5.8 Member of the eukaryotic histone-like transcription factor (CBF or NF-Y) and archaeal histone family T26A5.9 dlc-1;T26A5.9 Protein with strong similarity to dynein light chain (protein inhibitor of neuronal nitric oxide synthase) (mouse Dnclc1), which is a component of the dynein motor complex and inhibits nitric oxide synthase, member of the dynein light chain type 1 family dlc-1 encodes a dynein light chain type 1 that affects pronuclear migrations and thus affects embryonic viability; also affects fertility, body wall morphology and integrity. T26A8.1 T26A8.1 Protein of unknown function T26A8.2 T26A8.2 Protein of unknown function T26A8.3 T26A8.3 Member of the transthyretin-like family, has moderate similarity to uncharacterized C. elegans F17E9.4 T26A8.4 T26A8.4 Protein containing three CCCH-type zinc finger domains, which bind DNA or RNA T26C11.1 T26C11.1 Protein containing a T-box domain, which bind DNA, has low similarity to uncharacterized C. elegans TBX-8 brachyury (weak) T26C11.2 T26C11.2 Protein of unknown function E. gracilis major membrane skeletal protein T26C11.3 T26C11.3 Protein of unknown function T26C11.4 T26C11.4 Protein with weak similarity to S. cerevisiae DDR48 (Stress protein induced by heat shock, DNA damage, or osmotic stress) T26C11.5 ceh-41;T26C11.5 Protein containing a homeobox domain (homeodomain), which are found in transcription factors paired-type homeobox protein; ceh-41 encodes a a ONECUT class CUT homeobox protein with a single N-terminal OCAM domain; the OCAM domain is a nematode-specific motif conserved between CEH-21, CEH-41, and T02B5.2; ceh-41 is one of three nematode-specific ONECUT genes in a cluster with ceh-21 and ceh-39; ceh-41 has no obvious function in mass RNAi assays. T26C11.6 ceh-21;T26C11.6 Protein containing two CUT domains, which bind DNA, contains two homeobox domains (homeodomains), which are found in transcription factors, has a region of moderate similarity to a region of hepatocyte nuclear factor-6 (rat Hnf6) homeobox; ceh-21 encodes a a ONECUT class CUT homeobox protein with a single N-terminal cut domain and an OCAM domain; the cut domain may be a compact DNA-binding domain composed of alpha helices; the OCAM domain is a nematode-specific motif conserved between CEH-21, CEH-41, and T02B5.2; ceh-21 is one of three nematode-specific ONECUT genes in a cluster with ceh-39 and ceh-41; CEH-21 may be required for muscle formation and differentiation, and is expressed in muscle precursor cells and differentiated gut cells; ceh-21 has no obvious function in mass RNAi assays. T26C11.7 ceh-39;T26C11.7 Homeodomain transcription factor; has similarity to human HNF6A hepatocyte nuclear factor alpha and OC-2 (ONECUT-2), homeodomain transcription factors with function in liver cells homeobox; ceh-39 encodes a a ONECUT class CUT homeobox protein with a single N-terminal cut domain; CEH-39 acts as an X-signal element (XSE) to affect sex determination; the cut domain may be a compact DNA-binding domain composed of alpha helices; ceh-39 is one of three nematode-specific ONECUT genes in a cluster with ceh-21 and ceh-41. T26C12.1 T26C12.1 Member of the decarboxylase (tentative) protein family acetolactate synthase T26C12.2 T26C12.2 Protein of unknown function T26C12.3 T26C12.3 Member of the Ras superfamily of GTP-binding proteins, contains a C-type lectin domain and a C3HC4 type (RING) zinc finger, has a region of low similarity to S. pombe Rhb1p, which is an essential GTPase with a function that is non-overlapping with Ras1p T26C12.4 gcy-23;T26C12.4 Protein containing two receptor family ligand binding domains, a protein kinase domain and an adenylate and guanylate cyclase catalytic domain, has low similarity to natriuretic peptide receptor A (mouse Npr1), which is a membrane-bound guanylate cyclase gcy-23 encodes a predicted transmembrane guanylyl cyclase that is expressed in the AFD thermosensory neurons; as loss of gcy-23 activity via RNA-mediated interference does not result in any abnormalities, the precise role of GCY-23 in C. elegans development and/or behavior is not yet known; however, expression in the AFD neurons suggests a possible role in thermotaxis. T26C5.1 T26C5.1 Protein containing glutathione S-transferase N-terminal and C-terminal domains, has low similarity to prostaglandin D2 synthase (human PGDS), which is a prostaglandin D synthase and a glutathione S-transferase that regulates non-rapid eye movement sleep glutathione S-transferase T26C5.2 T26C5.2 Protein containing three PAN domains, which may mediate protein-protein or protein-carbohydrate interactions T26C5.3 T26C5.3 Member of the acetyl-coenzyme A transporter (AcCoAT) protein family Yeast YB70 like; This gene encodes a protein predicted by Eisenberg and coworkers, with 68% accuracy, to be mitochondrial. T26C5.4 T26C5.4 Protein of unknown function T26E3.1 T26E3.1 Member of the C-type lectin family, has weak similarity to human neurocan and versican chondroitin sulfate proteoglycans C-type lectin T26E3.2 T26E3.2 Protein with weak similarity to S. cerevisiae YSA1, which is a nucleoside diphosphate-sugar hydrolase of the MutT nudix family MUTT protein like; The ndx-1 gene encodes a NUDIX hydrolase. T26E3.3 par-6;T26E3.3 Protein that may direct asymmetric distribution of cytoplasmic determinants during early embryonic cell divisions PDZ domain (Also known as DHR or GLGF).; PAR-6 protein is required for the localization of PAR-3 to the apical surface of embryonic cells. T26E3.4 T26E3.4 Protein of unknown function, has low similarity to uncharacterized S. pombe Spcc1393.09cp T26E3.5 T26E3.5 Protein containing an F-box domain, which serve as a link between a target protein and a ubiquitin-conjugating enzyme This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins. T26E3.6 T26E3.6 Protein of unknown function fibrillin T26E3.7 T26E3.7 Protein of unknown function, has a region of strong similarity to a region of cardiac muscle ATP synthase H+ transporting mitochondrial F1 complex alpha subunit isoform 1 (human ATP5A1), which is part of the synthase complex that catalyzes ATP synthesis ATP synthase alpha and beta subunits; This gene encodes a protein predicted by Eisenberg and coworkers, with 68% accuracy, to be mitochondrial. T26E3.8 T26E3.8 Protein of unknown function, has weak similarity to C. elegans W04A8.3 T26E3.9 T26E3.9 G protein-coupled receptor; member of a subfamily with SRA proteins, which are expressed in chemosensory neurons; no homolog found in human or D. melanogaster 7TM chemoreceptor, sra family T26E4.1 T26E4.1 Protein containing a DUF41 domain of unknown function, has low similarity to uncharacterized C. elegans Y73F8A.18 T26E4.10 T26E4.10 Protein of unknown function, has strong similarity to uncharacterized C. elegans T26E4.9 T26E4.11 T26E4.11 Protein containing a nuclear hormone receptor C4-type zinc finger domain, which bind DNA and may be involved in regulation of transcription, has low similarity to uncharacterized C. elegans T05G11.4 7TM chemoreceptor, srw family T26E4.12 T26E4.12 Protein of unknown function, has very strong similarity to uncharacterized C. elegans M01B2.2 T26E4.13 T26E4.13 Protein containing a DUF40 domain of unknown function, which contain four conserved cysteines, has strong similarity to uncharacterized C. elegans M01B2.4 T26E4.14 T26E4.14 Protein of unknown function, has strong similarity to uncharacterized C. elegans M01B2.9 7 transmembrane receptor (rhodopsin family) T26E4.15 T26E4.15 Member of the rhodopsin family of G-protein coupled receptors (GPCR), protein with strong similarity to uncharacterized C. elegans M01B2.7 7 transmembrane receptor (rhodopsin family) T26E4.2 T26E4.2 Protein with moderate similarity to C. elegans C03G6.13 gene product T26E4.3 T26E4.3 Protein of unknown function, has moderate similarity to uncharacterized C. elegans F08A8.5 T26E4.4 T26E4.4 Protein of unknown function, has high similarity to uncharacterized C. elegans T26E4.5 T26E4.5 T26E4.5 Protein of unknown function, has high similarity to uncharacterized C. elegans T26E4.4 T26E4.6 T26E4.6 Protein of unknown function, has high similarity to uncharacterized C. elegans F44G3.5 T26E4.7 T26E4.7 Member of an uncharacterized protein family T26E4.8 T26E4.8 Protein containing nuclear hormone receptor C4-type zinc finger and ligand-binding domains, has weak similarity to C. elegans NHR-51, which is involved in developmental processes Ligand-binding domain of nuclear hormone receptors, Zinc finger, C4 type (two domains) T26E4.9 T26E4.9 Protein of unknown function, has strong similarity to uncharacterized C. elegans T26E4.10 T26F2.1 T26F2.1 Member of the plant chitinase class I family, which hydrolyze the beta-1,4-N-acetyl-D-glucosamine bonds in chitin polymers destroying cell walls of fungal and insect pathogens, has very strong similarity to uncharacterized C. elegans R10D12.15 chitinase T26F2.2 T26F2.2 Protein with moderate similarity to C. elegans dom-3 gene product T26G10.1 T26G10.1 Protein with high similarity to S. cerevisiae Rrp3p, which is a helicase required for maturation of pre-rRNA, member of the DEAD or DEAH box ATP-dependent RNA helicase family and contains a helicase conserved C-terminal domain RNA helicase T26G10.3 T26G10.3 Member of the ribosomal S24e family, which are part of the small ribosomal subunit Ribosomal protein S24 T26G10.4 T26G10.4 Putative ortholog of C. elegans T27C5.9 gene product T26G10.5 T26G10.5 Protein of unknown function T26H10.1 acr-4;des-2;K03B8.10;T26H10.1 Acetylcholine-gated channel subunit nicotinic acetylcholine receptor; des-2 encodes an alpha subunit of nicotinic acetylcholine receptor (nAChR), predicted to be a ligand-gated ion channel regulating the fast action of acetylcholine at neuromuscular junctions and in the nervous system; DES-2 is coexpressed with and genetically interacts with DEG-3, which which it probably forms heteromultimers, and DES-2 falls into the 'DEG-3' class of nAChR subunits, probably unique to nematodes, which includes DEG-3, ACR-5, ACR-17, ACR-18 ACR-20, and ACR-23. T26H2.1 T26H2.1 Protein containing an F-box domain, which serve as a link between a target protein and a ubiquitin-conjugating enzyme, has high similarity to uncharacterized C. elegans T26H2.3 This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins; its encoded protein also contains a Pfam-B45 motif of presently unknown function. T26H2.2 T26H2.2 Protein containing an F-box domain, which serve as a link between a target protein and a ubiquitin-conjugating enzyme, has moderate similarity to uncharacterized C. elegans T26H2.4 This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins; its encoded protein also contains a Pfam-B45 motif of presently unknown function. T26H2.3 T26H2.3 Protein containing an F-box domain, which serve as a link between a target protein and a ubiquitin-conjugating enzyme, has high similarity to uncharacterized C. elegans T26H2.1 This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins; its encoded protein also contains a Pfam-B45 motif of presently unknown function. T26H2.4 T26H2.4 Protein containing an F-box domain, which serve as a link between a target protein and a ubiquitin-conjugating enzyme, has moderate similarity to uncharacterized C. elegans T26H2.2 This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins; its encoded protein also contains a Pfam-B45 motif of presently unknown function. T26H2.5 T26H2.5 Protein containing a ZZ zinc finger, has moderate similarity to uncharacterized C. elegans Y32B12A.1 Zinc finger present in dystrophin, CBP/p300 T26H2.6 T26H2.6 Member of the 7-transmembrane chemoreceptor family of G-protein coupled receptors (GPCR), has low similarity to C. elegans ODR-10, which is a G protein-coupled receptor involved in the odorant response T26H2.7 T26H2.7 Protein containing a DUF33 domain of unknown function, has high similarity to uncharacterized C. elegans F37C4.2 T26H2.8 T26H2.8 Protein of unknown function, has high similarity to uncharacterized C. elegans F36D3.3 T26H2.9 nhr-79;T26H2.9 Protein containing a nuclear hormone receptor ligand-binding domain and a nuclear hormone receptor C4-type zinc finger domain, which bind DNA and may be involved in regulation of transcription, has weak similarity to C. elegans NHR-80 Zinc finger, C4 type (two domains) T26H5.1 T26H5.1 Member of the 7-transmembrane chemoreceptor family of G-protein coupled receptors (GPCR), has high similarity to uncharacterized C. elegans T06E6.9 T26H5.2 T26H5.2 Member of the 7-transmembrane chemoreceptor family of G-protein coupled receptors (GPCR) T26H5.3 T26H5.3 Member of the 7-transmembrane chemoreceptor family of G-protein coupled receptors (GPCR), has strong similarity to uncharacterized C. elegans F08E10.1 T26H5.4 T26H5.4 Protein of unknown function, has weak similarity to C. elegans K01D12.9 T26H5.5 T26H5.5 Protein of unknown function, has moderate similarity to uncharacterized C. elegans T08G3.10 7TM chemoreceptor, srw family T26H5.8 T26H5.8 Protein of unknown function, has high similarity to uncharacterized C. elegans F08A8.5 T26H8.1 T26H8.1 Member of the transposase family, which are required for excising and inserting mobile genetic elements, has very strong similarity to uncharacterized C. elegans F16D3.5 transposase T26H8.2 T26H8.2 Member of the rhodopsin family of G-protein coupled receptors (GPCR), has high similarity to uncharacterized C. elegans Y43B11AL.2 7TM receptor, srx family T26H8.3 T26H8.3 Protein of unknown function, has moderate similarity to uncharacterized C. elegans T26H8.2 T27A1.1 T27A1.1 Protein of unknown function 7TM chemoreceptor, srh family T27A1.2 T27A1.2 Protein of unknown function, has high similarity to uncharacterized C. elegans C24H12.11 T27A1.3 T27A1.3 Protein containing an F-box domain, which serve as a link between a target protein and a ubiquitin-conjugating enzyme, has high similarity to uncharacterized C. elegans C24H12.11 This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins. T27A1.4 T27A1.4 Protein containing a neurotransmitter-gated ion-channel ligand binding domain, has low similarity to glycine receptor alpha 2 subunit (human GLRA2), which is a component of the glycine receptor chloride channel that binds strychnine ionic channel protein T27A1.5 T27A1.5 Member of the transmembrane amino acid transporter (permease) family, has low similarity to lysosomal amino acid transporter 1 (rat Lyaat1), which transports small neutral amino acids and some neurotransmitters T27A1.6 mab-9;tbx-12;Ce-tbx-12;T27A1.6 Transcriptional regulator; member of the Brachyury T-box family of DNA binding proteins; involved in cell differentiation in the male tail, hermaphrodite rectum, and locomotory system transcription regulator; mab-9 encodes a member of the T-box family of transcriptional regulators containing a 200-amino acid T-box DNA-binding domain most similar to mouse Brachyury; mab-9 is involved in hindgut and mail tail development, specifically affecting the fate of two posterior blast cells in the hindgut, B and F; in the male this results in a grossly abnormal tail lacking spicules, and renders them incapable of mating; in the hermaphrodite this results in hindgut defects; mab-9 may also be part of a network of T-box genes that includes tbx-8, tbx-9 and vab-7 and is important for the correct patterning of posterior cells in the developing embryo; mab-9 affects movement to some extent though the basis for this defect is unknown; MAB-9 localizes to the nucleus of B and F and their descendents during development. T27A1.7 T27A1.7 Protein with similarity to C. elegans olfactory receptor ODR-10 7TM chemoreceptor, srh family T27A10.2 T27A10.2 Protein of unknown function T27A10.3 T27A10.3 Member of the choline or ethanolamine kinase family, which catalyze the formation of phosphatidylcholine by the CDP-choline pathway, has moderate similarity to ethanolamine kinase 1 (human EKI1), which catalyzes ethanolamine phosphorylation choline kinase T27A10.5 T27A10.5 Protein of unknown function T27A10.6 T27A10.6 Protein of unknown function, has weak similarity to C. elegans H30A04.1 T27A10.7 T27A10.7 Protein containing a CRAL-TRIO domain, has weak similarity to SEC14-like 2 (tocopherol-associated protein, human SEC14L2), which is an alpha-tocopherol-binding protein that activates transcription in an alpha-tocopherol-dependent manner T27A3.1 T27A3.1 Putative coiled-coil protein, has weak similarity to S. cerevisiae Uso1p T27A3.2 T27A3.2 Member of the ubiquitin carboxyl-terminal hydrolase family 2, contains ubiquitin carboxyl-terminal hydrolases family 2, UBA (ubiquitin associated) or TS-N, and Zn-finger in ubiquitin-hydrolases and other proteins domains, has low similarity to human USP5 ubiquitin carboxyl-terminal hydrolase T27A3.3 T27A3.3 Protein containing a major sperm protein (MSP) domain, which are involved in sperm motility, has very strong similarity to uncharacterized C. elegans K07F5.9 T27A3.4 T27A3.4 Protein of unknown function, has very strong similarity to uncharacterized C. elegans C10G11.9 T27A3.5 T27A3.5 Member of the protein-tyrosine phosphatase family, which are involved in control of cell growth, proliferation, differentiation and transformation, has moderate similarity to C. elegans F10G8.1, which is a putative tyrosine protein phosphatase T27A3.6 T27A3.6 Member of the molydopterin converting factor subunit 2 family, has a region of moderate similarity to molybdenum cofactor synthesis 2 (molybdopterin synthase) (human MOCS2), which catalyzes the conversion of precursor Z to molybdopterin T27A3.6 is orthologous to the human gene MOLYBDENUM COFACTOR BIOSYSTHESIS PROTEIN E (MOCS2; OMIM:603708), which when mutated leads to disease. T27A3.7 T27A3.7 Protein of unknown function T27A8.1 T27A8.1 Putative zinc carboxypeptidase, has strong similarity to human carboxypeptidases; may be anchored to the membrane of a secretory vesicle or the Golgi apparatus carboxypeptidase T27A8.2 T27A8.2 Contains a forkhead domain forkhead domain T27A8.3 T27A8.3 Protein of unknown function, has a region of high similarity to a region of methionine aminopeptidase 2 (human METAP2), which is a positive regulator of translation that inhibits apoptosis and may be used as an anticancer therapy methionine aminopeptidase 2 T27A8.4 T27A8.4 Protein of unknown function T27A8.5 T27A8.5 Protein of unknown function, putative paralog of C. elegans C36C9.4 T27B1.1 T27B1.1 Protein containing four WD (WD-40 repeats) and two TPR (tetratrico peptide repeat) domains, which may mediate protein-protein interactions, has moderate similarity to selective LIM binding factor (rat Slb), which is a putative transcription cofactor leucine zipper transcription factor(weak); osm-1 encodes a predicted intraflagellar transport (IFT) raft protein and is a presumptive cargo molecule for kinesinII, and OSM-1 is required along with OSM-6 for the proper assembly of the middle segments of sensory cilia; osm-1 may act in a pathway with avr-14 to affect resistance to ivermectin-induced cessation of pumping, and mutants are defective in avoidance of solutions of high osmotic strength. T27B1.2 T27B1.2 Zinc finger protein of unknown function zinc finger T27B7.1 nhr-59;T27B7.1 Member of the nuclear hormone receptor/Zinc finger protein family T27B7.2 T27B7.2 Protein containing a nuclear hormone receptor C4-type zinc finger domain, which bind DNA and may be involved in regulation of transcription, has moderate similarity to C. elegans NHR-58 zinc finger protein T27B7.3 T27B7.3 Protein containing a nuclear hormone receptor ligand-binding domain and a nuclear hormone receptor C4-type zinc finger domain, which bind DNA and may be involved in regulation of transcription, has moderate similarity to C. elegans NHR-58 zinc finger protein T27B7.4 T27B7.4 Member of the nuclear hormone receptor/Zinc finger protein family zinc finger protein T27B7.5 T27B7.5 Protein containing a nuclear hormone receptor C4-type zinc finger domain, has low similarity to C. elegans NHR-58, which is involved in embryogenesis and morphogenesis zinc finger protein T27B7.6 T27B7.6 Protein containing nuclear hormone receptor C4-type zinc finger and ligand-binding domains, has moderate similarity to C. elegans NHR-58, which is a putative ligand-dependent nuclear receptor that functions in embryogenesis and morphogenesis zinc finger protein T27B7.7 T27B7.7 Protein containing a DUF38 domain of unknown function T27C10.1 T27C10.1 Protein of unknown function, has strong similarity to C. elegans T27C10.2 7TM chemoreceptor, srt family T27C10.2 T27C10.2 Protein of unknown function, has strong similarity to C. elegans T27C10.1 7TM chemoreceptor, srt family T27C10.3 T27C10.3 Protein with weak similarity to C. elegans Y53C12A.4 gene product T27C10.4 T27C10.4 Member of the BTB/POZ domain protein family calcium-binding protein T27C10.5 T27C10.5 Protein containing a protein kinase domain, has a region of low similarity to a region of human mitogen-activated protein kinase kinase kinase 10 (mixed lineage kinase 2, MAP3K10), which is involved in JNK activation and induction of apoptosis T27C10.6 T27C10.6 Protein containing five ankyrin (Ank) repeats, which may mediate protein-protein interactions Dictyostelium gene (GbpC) homolog; lrk-1 encodes a homolog of GbpC, the primary high-affinity cGMP-binding protein in Dictyostelium discoideum, which is required for normal phosphorylation and cytoskeletal assembly of myosin during chemotaxis; GbpC is generally conserved in eukaryotes, with homologs in mammals and flies. T27C4.1 T27C4.1 Protein of unknown function T27C4.2 T27C4.2 Protein of unknown function T27C4.3 T27C4.3 Member of the 7-transmembrane chemoreceptor family of G-protein coupled receptors (GPCR), has low similarity to C. elegans ODR-10, which is a G protein-coupled receptor involved in odorant response 7TM chemoreceptor, str family T27C4.4 lin-40;let-432;egr-1;T27C4.4 Required for normal posterior morphology, has strong similarity to human metastasis-associated protein MTA1 (Hs.101448, isolated from malignant melanoma cells) egr-1 encodes a homolog of human MTA1, part of an ATP-dependent complex with nucleosome remodelling and histone deacetylation activities that may promote tumor metastasis; in conjunction with its paralog egl-27, egr-1 is required for proper organization in all parts of the embryo, and for the embryonic expression of hlh-8. T27C5.1 T27C5.1 Member of the 7-transmembrane chemoreceptor family of G-protein coupled receptors (GPCR), has moderate similarity to uncharacterized C. elegans F21H7.7 G-protein coupled receptor, srh family T27C5.10 T27C5.10 Protein of unknown function, has strong similarity to C. elegans F40D4.8 T27C5.2 T27C5.2 Putative G protein-coupled receptor, no homolog found in human or D. melanogaster T27C5.3 T27C5.3 Protein of unknown function, has strong similarity to C. elegans Y102A5C.24 T27C5.4 T27C5.4 Protein containing a DUF216 domain of unknown function, has high similarity to uncharacterized C. elegans Y102A5C.26 T27C5.5 T27C5.5 Member of the 7-transmembrane chemoreceptor family of G-protein coupled receptors (GPCR), has strong similarity to uncharacterized C. elegans Y102A5C.31 T27C5.6 T27C5.6 Member of the 7-transmembrane chemoreceptor family of G-protein coupled receptors (GPCR) T27C5.7 T27C5.7 Protein of unknown function, has strong similarity to C. elegans F49D11.3 T27C5.8 T27C5.8 Member of an uncharacterized protein family T27C5.9 T27C5.9 Member of the reverse trancriptase family, contains a ubiquitin-like protein-specific protease family C-terminal catalytic domain, has a region of weak similarity to a region of LINE retrotransposable element 1 (human LRE1) Reverse transcriptase (RNA-dependent DNA polymerase) T27D1.1 cyp-9;T27D1.1 Cyclophilin-related peptidylprolyl cis-trans-isomerase cyclophilin related protein; The cyp-9 gene encodes a peptidyl prolyl cis-trans isomerase most similar to human cyclophilin G (OMIM:606093); CYP-9 likely functions as a catalyst in the folding and modification of cuticle collagens and is expressed in the cuticle synthesizing syncytial hypodermis most strongly at the mid-L3 and mid-L4 larval stages, the intermoult period when collagens are synthesized. T27D1.3 T27D1.3 Member of the rhodopsin family of G-protein coupled receptors (GPCR), has low similarity to mu opioid receptor 1 (human OPRM1), which signals through an inhibitory G-protein in sensory perception and processing and may be associated with drug addiction G-protein coupled receptor T27D12.1 T27D12.1 Protein with similarity to human and D. melanogaster sodium-dependent inorganic phosphate cotransporters, member of the major facilitator superfamily sodium/phosphate transporter T27D12.2 clc-1;clh-1;T27D12.2 Chloride channel protein chloride channel protein; clh-1 encodes two CLC-type chloride channels via alternative splicing, homologous to human CLC1 (OMIM:118425) and CLC2 (OMIM:600570); CLH-1a and CLH-1b are required for maintenance of normal body shape; null mutations of clh-1 cause abnormal alae and a wider body than normal, with the body phenotype being reversible by culture medium of high osmolarity. T27D12.3 T27D12.3 Protein containing a C-type lectin domain, which mediate calcium-dependent carbohydrate recognition, has high similarity to uncharacterized C. elegans W04H10.4 T27D12.4 T27D12.4 Putative ortholog of C. elegans Y6D1A.D gene product pes-5 encodes a novel protein that contains several arginine-rich regions, but no recognizably conserved domains; pes-5 was identified in promoter trapping screens, and as loss of pes-5 activity via RNA-mediated interference (RNAi) does not result in any obvious abnormalities, the precise role of pes-5 in C. elegans development and/or behavior is not yet known; a pes-5 reporter is expressed in most cells in the early embryo from the 28-cell stage through the end of cellular proliferation, with no expression detected past the comma stage of embryogenesis or in post-embryonic stages; embryonic expression is particularly strong in cells derived from the AB lineage. T27E4.1 T27E4.1 Protein of unknown function T27E4.2 hsp-16;hsp-16.1;hsp-16A;hsp-16A1;hsp16-1;hsp16-1b;T27E4.8;T27E4.2 Member of the C .elegans hsp-16 family; identical to hsp-16.11 heat shock protein HSP16-1; hsp-16.11 encodes a 16-kD heat shock protein (HSP) that is a member of the hsp16/hsp20/alphaB-crystallin (HSP16) family of heat shock proteins, and that is identical to the protein encoded by hsp-16.1; hsp-16.11 expression is induced in response to heat shock or other environmental stresses; HSP-16.11 is likely to function as passive ligand temporarily preventing unfolded proteins from aggregating; HSP-16.11 has been shown to interact with intracellular human beta amyloid peptide, a primary component of the extracellular plaques found in Alzheimer's disease. T27E4.3 hsp-16.48;hsp16-48;hsp16-48a;T27E4.3 Member of the Hsp20 or alpha crystallin family, has low similarity to alpha-B crystallin (mouse Cryab), which functions as a molecular chaperone and is involved in apoptosis and cell remodeling heat shock protein HSP16-48; hsp-16.48 encodes a 16-kD heat shock protein (HSP) that is a member of the hsp16/hsp20/alphaB-crystallin (HSP16) family of heat shock proteins; an hsp-16.48 reporter fusion, expressed broadly but most strongly in body muscle and hypodermis, is induced solely in response to heat shock or other environmental stresses; expression is detectable in somatic tissues in post-gastrulation embryos, all larval stages, and in adults; HSP-16.48 is likely to function as a passive ligand temporarily preventing unfolded proteins from aggregating. T27E4.4 T27E4.4 Protein of unknown function T27E4.5 T27E4.5 Protein of unknown function, has weak similarity to C. elegans F54E2.2 T27E4.6 T27E4.6 Member of the uncharacterized protein family UPF0063, has low similarity to uncharacterized C. elegans F52F10.3 T27E4.7 T27E4.7 Protein of unknown function T27E4.9 hsp-16.49;hsp16-48;hsp16-48b;T27E4.9 Member of the Hsp20 or alpha crystallin family, has low similarity to alpha A crystallin (human CRYAA), which is a major structural protein of the eye lens that acts as a molecular chaperone and protects lens epithelium from UVA stress heat shock protein HSP16-48; hsp-16.49 encodes a 16-kD heat shock protein (HSP) that is a member of the hsp16/hsp20/alphaB-crystallin (HSP16) family of heat shock proteins, and that is identical to the protein encoded by hsp-16.48; HSP-16.49 is likely to function as a passive ligand temporarily preventing unfolded proteins from aggregating. T27E7.1 T27E7.1 Protein with strong similarity to C. elegans Y53C10A.H gene product T27E7.2 T27E7.2 Member of the 7-transmembrane chemoreceptor family of G-protein coupled receptors (GPCR), has moderate similarity to uncharacterized C. elegans T21B4.10 T27E7.3 T27E7.3 Protein of unknown function, has strong similarity to C. elegans T27E7.5 T27E7.4 T27E7.4 Protein containing a DUF216 domain of unknown function, has high similarity to uncharacterized C. elegans T27E7.3 T27E7.5 T27E7.5 Protein of unknown function, has strong similarity to C. elegans T27E7.3 T27E7.6 T27E7.6 Member of an uncharacterized protein family T27E7.7 T27E7.7 Member of the transposase family, which are required for excising and inserting mobile genetic elements, has very strong similarity to uncharacterized C. elegans F44F4.8 transposase T27E9.1 T27E9.1 Protein with high similarity to solute carrier family 25 member 4 (mouse Slc25a4), which is an adenine nucleotide transporter that functions in metabolism and apoptosis, member of the mitochondrial carrier protein family of membrane transporters ADP/ATP carrier protein T27E9.2 T27E9.2 Small protein with strong similarity to human and bovine ubiquinol-cytochrome C reductase complex 11 Kd protein precursors ubiquinol-cytochrome c reductase complexn 11 KD protein T27E9.3 cdk-5;T27E9.3 Protein with high similarity to cyclin-dependent protein kinase 5 (rat Cdk5), which is a serine-threonine kinase that associates with the regulatory subunit p35 (rat Cdk5r) and phosphorylates neuronal proteins, contains a protein kinase domain serine/threonine kinase (CDC2/CDKX subfamily); cdk-5 encodes a putative homolog of cyclin dependent kinase 5 that affects pronuclear migration and rotation in one-cell embryos and may affect neuronal development; expressed in neurons. T27E9.4 T27E9.4 Protein containing 24 Kelch motif domains and four BTB (BR-C, ttk and babor) or POZ (Pox virus and zinc finger) domains, has moderate similarity to kelch-like 2 (Mayven) (human KLHL2), which is a protein-binding protein and putative transporter ring canal protein like T27E9.5 T27E9.5 Member of the phosphatidyl serine synthase family, which replace the head group of phospholipids with L-serine, has moderate similarity to phosphatidylserine synthase 1 (mouse Ptdss1) phosphatidylserine synthase I T27E9.6 T27E9.6 Protein of unknown function T27E9.7 T27E9.7 Protein with high similarity to S. cerevisiae Kre30p, which is a putative ATP-binding cassette (ABC) transporter involved in cell growth or maintenance, member of the ABC transporter family ABC transporters (2 domains) T27E9.8 T27E9.8 Member of an uncharacterized protein family This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins; its encoded protein also contains a Pfam-B45 motif of presently unknown function. T27E9.9 T27E9.9 Protein containing a neurotransmitter-gated ion-channel ligand binding domain, has low similarity to glycine receptor subunit alpha 3 (human GLRA3), which functions as a ligand-binding component of the neuronal glycine receptor ligand-gated ion channel T27F2.1 T27F2.1;Ce-SKIP Putative transcription regulator Drosophila puff specific protein BX42 like T27F2.2 T27F2.2 Protein containing a Rap or Ran-GAP domain, which activate nuclear regulatory proteins, has low similarity to signal-induced proliferation associated gene 1 (human SIPA1), which is a mitogen-induced GTPase activating protein for Rap1 and Rap2 Mouse GTPASE-ACTIVATING PROTEIN SPA-1 like; The T27F2.2 gene encodes a homoglog of human TSC2, which when mutated leads to tuberous sclerosis (OMIM:191090). T27F2.3 bir-1;T27F2.3 Contains a baculovirus IAP repeat and is required for chromosome alignment, separation/segregation, and condensation Inhibitor of Apoptosis domain.; bir-1 encodes a homolog of the baculoviral inhibitor-of-apoptosis (IAP) repeat (BIR) proteins (BIRPs) family. T27F2.4 T27F2.4 Protein of unknown function T27F6.1 T27F6.1 Member of the core-2 or I-branching enzyme family, which form blood group I-antigens or side-chains of O-glycans, has weak similarity to mucin type beta-1 6-N-acetylglucosaminyltransferase (human GCNT3) T27F6.2 T27F6.2 Member of the C-type lectin family, has similarity to human C-type mannose receptor MRC1, has similarity to D. melanogaster TOLLOID and TOLKIN proteins CUB domain, Lectin C-type domain short and long forms (2 domains) T27F6.4 T27F6.4 Protein of unknown function T27F6.5 T27F6.5 Protein containing a tRNA synthetase class II core domain (G, H, P, S and T), and an anticodon binding domain, which are found in histidyl, glycyl, threonyl and prolyl tRNA synthetases, has moderate similarity to uncharacterized human DKFZP727A071 tRNA synthetases class II (Gly, His, Pro and Ser); This gene encodes a protein predicted by Eisenberg and coworkers, with 52% accuracy, to be mitochondrial. T27F6.6 T27F6.6 Protein with low similarity to neutral sphingomyelinase (rat Smpd2), which is a magnesium-dependent enzyme that catalyzes sphingomyelin and lyso-platelet activating factor hydrolysis and functions in ceramide synthesis T27F6.7 T27F6.7 Protein of unknown function T27F6.8 T27F6.8 Protein of unknown function, has weak similarity to C. elegans R13H4.5 This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins. T27F7.1 T27F7.1 Protein with similarity to S. cerevisiae Vps24p, which is involved in sorting of proteins in pre-vacuolar endosome T27F7.2 T27F7.2 Protein contains putative PTB (phosphotyrosine-binding) and SH2 (Src homology 2) domains T27F7.2 encodes three proteins by multiple splicing, two of which (T27F7.2A-B) are fully orthologous to vertebrate Shc proteins (e.g., p52/p46SHC and p66SHC); like their orthologs, T27F7.2A-B have a PTB and an SH2 domain in N- to C-terminal order; T27F7.2 is expressed in gastrulating embryos (probably in neural precursors); T27F7.2 might be involved in RAS signal transduction or regulation of apoptosis. T27F7.3 PIG-B;T27F7.3 Member of the translation initiation factor SUI1 family, has moderate similarity to human PIGB, which is a putative transmembrane endoplasmic reticulum mannosyltransferase that is required for synthesis of GPI anchors T28A11.1 T28A11.1 Member of the 7-transmembrane chemoreceptor family of G-protein coupled receptors (GPCR), has strong similarity to uncharacterized C. elegans C17B7.1 7TM chemoreceptor, str family T28A11.10 T28A11.10 Member of the 7-transmembrane chemoreceptor family of G-protein coupled receptors (GPCR), has low similarity to C. elegans ODR-10, which is a G protein-coupled receptor involved in odorant response 7TM chemoreceptor, srj family T28A11.11 T28A11.11 Member of the glutathione S-transferase protein family, has similarity to human and D. melanogaster glutathione S-transferases glutathione S-transferase T28A11.12 T28A11.12 Putative ortholog of C. elegans Y40B10B.2 gene product 7TM chemoreceptor, srj family T28A11.13 T28A11.13 Member of the thioredoxin family, which are small enzymes involved in redox reactions, has moderate similarity to C. elegans R05H5.3, which is a putative nuclear thioredoxin involved in embryogenesis and morphogenesis T28A11.14 T28A11.14 TcA transposase transposase T28A11.15 T28A11.15 Protein of unknown function, putative paralog of C. elegans C03A7.9 7TM chemoreceptor, srt family T28A11.16 T28A11.16 Protein containing a DUF19 domain of unknown function, which contain twelve conserved cysteines, has high similarity to uncharacterized C. elegans C17B7.4 T28A11.17 T28A11.17 Member of the M13 peptidase family of zinc metalloproteases, has strong similarity to uncharacterized C. elegans C17B7.8 T28A11.17 encodes a neprilysin; neprilysins are thermolysin-like zinc metallopeptidases, found on the outer surface of animal cells, that negatively regulate small signalling peptides (e.g., enkephalin, tachykinin, insulin, and natriuretic peptides) by cleaving them; T28A11.17 has no clear orthologs in other organisms. T28A11.18 T28A11.18 Protein containing a DUF19 domain of unknown function, which contain twelve conserved cysteines, has strong similarity to uncharacterized C. elegans C17B7.9 T28A11.19 T28A11.19 Protein containing a DUF19 domain of unknown function, which contain twelve conserved cysteines, has strong similarity to uncharacterized C. elegans T20D4.11 T28A11.2 T28A11.2 Protein containing two DUF19 domains of unknown function, which contain twelve conserved cysteines, has high similarity to uncharacterized C. elegans C17B7.2 T28A11.20 T28A11.20 Member of an uncharacterized protein family T28A11.20 encodes a neprilysin; neprilysins are thermolysin-like zinc metallopeptidases, found on the outer surface of animal cells, that negatively regulate small signalling peptides (e.g., enkephalin, tachykinin, insulin, and natriuretic peptides) by cleaving them; T28A11.20 has no clear orthologs in other organisms. T28A11.21 T28A11.21 Member of an uncharacterized protein family This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins; this gene's encoded protein also contains an FTH/DUF38 motif, which may also mediate protein-protein interaction. T28A11.3 T28A11.3 Protein containing a DUF19 domain of unknown function, which contain twelve conserved cysteines, has strong similarity to uncharacterized C. elegans C17B7.3 T28A11.4 T28A11.4 Protein of unknown function, has moderate similarity to C. elegans E04F6.9 T28A11.5 T28A11.5 Protein containing a DUF19 domain of unknown function, which contain twelve conserved cysteines, has strong similarity to uncharacterized C. elegans C17B7.4 T28A11.6 T28A11.6 Protein of unknown function, has moderate similarity to C. elegans F35F10.10 T28A11.7 T28A11.7 Protein containing a DUF40 domain of unknown function, which contain four conserved cysteines, has strong similarity to uncharacterized C. elegans F35F10.9 T28A11.9 T28A11.9 Member of the 7-transmembrane chemoreceptor family of G-protein coupled receptors (GPCR), has high similarity to uncharacterized C. elegans T20C4.1 7TM chemoreceptor, srj family T28A8.1 T28A8.1 Member of the ion transport family, which include calcium, sodium, and potassium channels, has low similarity to potassium channel subfamily K member 16 (human KCNK16), which is a subunit of a pancreatic 2P domain background potassium channel T28A8.2 T28A8.2 Member of an uncharacterized protein family T28A8.3 T28A8.3 Member of a protein family T28A8.4 T28A8.4 Member of an uncharacterized protein family T28A8.5 T28A8.5 Protein of unknown function, has moderate similarity to C. elegans B0205.1 T28A8.6 T28A8.6 Member of an uncharacterized protein family T28A8.7 T28A8.7 Member of the mutL, hexB, or PMS1 family, which are DNA mismatch repair proteins, contains a histidine kinase-like ATPase domain, has low similarity to mutL (E. coli) homolog 1 (human MLH1), which is a DNA mismatch repair protein DNA mismatch repair protein; The mlh-1 gene encodes a DNA mismatch repair protein homolog that is orthologous to human MLH1. T28B11.1 T28B11.1 Protein of unknown function This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins. T28B4.1 T28B4.1 Protein containing an F-box domain, has weak similarity to S. cerevisiae Grr1p, an F-box protein involved in SCF/ubiquitin-mediated degradation of cell cycle regulators This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins. T28B4.2 T28B4.2 Protein of unknown function T28B4.3 T28B4.3 Member of the transthyretin-like family, has high similarity to uncharacterized C. elegans C40H1.5 T28B4.4 T28B4.4 Protein of unknown function, has weak similarity to C. elegans C09F12.1 T28B4.4 encodes a claudin homolog that may be required for normal cohesion of apical junctions in epithelia; T28B4.4 is worm-specific, weakly similar to CLC-1; T28B4.4 has no obvious function in mass RNAi assays; claudins are integral membrane proteins with four transmembrane sequences that are found in mammalian tight junctions (TJs), induce TJs when transgenically expressed in cells normally lacking them, and can mediate the specific conductance of of specific ions (e.g., magnesium or calcium) through TJs while blocking the flow of water. T28B8.1 T28B8.1 Protein of unknown function T28B8.2 ins-18;Ceinsulin-1;T28B8.2 Insulin-like protein of the type-beta subfamily; may be a ligand for the DAF-2 receptor insulin-like growth factor I like; The ins-18 gene encodes an insulin/IGF-like peptide that may act in a common pathway with daf-2 to regulate lifespan. T28B8.3 T28B8.3 Protein of unknown function, has high similarity to uncharacterized C. elegans T28B8.4 Human mRNA (KIAA0077) product like T28B8.4 T28B8.4 Protein of unknown function, has high similarity to uncharacterized C. elegans T28B8.3 T28B8.5 T28B8.5 Member of the amiloride-sensitive sodium channel family, which are involved in sodium reabsorption, has low similarity to C. elegans MEC-10, which is involved in mechanosensory perception mechanosensory protein T28C12.1 T28C12.1 Member of the multidrug resistance (putative) protein family T28C12.2 T28C12.2 Member of the multidrug resistance (putative) protein family T28C12.3 T28C12.3 Member of a protein family This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins; this gene's encoded protein also contains an FTH/DUF38 motif, which may also mediate protein-protein interaction. T28C12.4 T28C12.4 Member of the carboxylesterase type B family, has low similarity to C. elegans GES-1, which is a carboxylesterase esterase T28C12.5 T28C12.5 Member of the carboxylesterase protein family esterase T28C12.6 T28C12.6 Protein of unknown function, has weak similarity to C. elegans F54E2.2 T28C6.1 T28C6.1 Protein of unknown function T28C6.2 T28C6.2 Protein of unknown function T28C6.3 T28C6.3 Protein of unknown function, has weak similarity to C. elegans Y71A12B.A T28C6.4 T28C6.4 Protein with high similarity to C. elegans DPY-16, which is a collagen involved in epithelial morphogenesis, contains two collagen triple helix repeats and one nematode cuticle collagen N-terminal domain cuticle collagen T28C6.5 T28C6.5 Protein of unknown function, has moderate similarity to C. elegans R102.7 T28C6.6 col-3;T28C6.6 Collagen cuticle collagen; col-3 encodes a collagen protein that affects body morphogenesis, larval viability, and locomotion in large scale RNAi screens; mRNA is expressed during all developmental stages examined (in embryos, during the L2 to dauer molt, during the dauer to L4 larval molt, and during the L4 to adult molt). T28C6.7 T28C6.7 Putative coiled-coil protein, has similarity to human a centromere protein CENPE T28C6.8 T28C6.8 Protein of unknown function T28D6.1 phy-1;dpy-18;Y47D3B.10;P4HA;T28D6.1 Prolyl 4-hydroxylase alpha subunit of mutlienzyme complex prolyl 4-hydroxylase T28D6.2 T28D6.2 Protein with strong similarity to alpha tubulin (C. elegans TBA-1), which is specific to meiotic spindles and mitotic spindles of neurons, member of the tubulin-FtzA family, which are involved in polymer formation tubulin alpha subunit T28D6.3 T28D6.3 Protein of unknown function T28D6.4 T28D6.4 Protein containing 15 ankyrin (Ank) repeats, which may mediate protein-protein interactions, has a region of low similarity to a region of inversin (mouse Invs), which determines left-right asymmetry during embryogenesis Ank repeat (8 domains) T28D6.5 T28D6.5 Protein of unknown function T28D6.6 T28D6.6 Putative ortholog of C. elegans C02F5.3 gene product T28D6.7 T28D6.7 Protein containing a START (Steroidogenic Acute Regulatory protein) domain, which is a lipid-binding domain in StAR, HD-ZIP and signalling proteins, has moderate similarity to serologically defined colon cancer antigen 28 (human SDCCAG28) T28D6.9 T28D6.9 Protein of unknown function T28D9.1 T28D9.1 Protein of unknown function T28D9.10 T28D9.10 Protein with high similarity to small nuclear ribonucleoprotein D1 polypeptide (human SNRPD1), which binds to the survival of motor neurons protein (human SMN1) and is a major autoantigen in systemic lupus erythematosus patients, member of the Sm family small nuclear ribonucleoprotein Sm D1 (snRNP core protein D1) T28D9.11 T28D9.11 Protein of unknown function T28D9.2 rsp-5;srp-3;CeSC35-2;T28D9.2 SR protein involved in mRNA splicing; member of the RNA recognition motif (aka RRM, RBD, Or RNP domain) protein family splicing factor T28D9.3 T28D9.3 Member of the phosphatidic acid phosphatase-related (PAP2) phosphoesterase family, has low similarity to phosphatidic acid phosphatase 2b (human PPAP2B), which dephosphorylates phosphatidic acid to supply diacylglycerol in glycerolipid biosynthesis T28D9.4 T28D9.4 Protein of unknown function T28D9.7 T28D9.7 Member of the amiloride-sensitive sodium channel family, which are involved in sodium reabsorption, has a region of weak similarity to proton-gated cation channel (acid-sensing ion channel 1) (rat Accn2), which is an amiloride-sensitive sodium channel degenerin T28D9.9 T28D9.9 Protein of unknown function, has weak similarity to C. elegans F54D10.3 T28F12.2 unc-62;nob-5;let-328;ceh-25;T28F12.2 Protein containing two homeobox domains (homeodomain), which are found in transcription factors, has moderate similarity to myeloid ecotropic viral integration site 1 (mouse Meis1), which is a transcription factor regulating limb axis development homeobox protein; unc-62 encodes a Meis-class homeodomain protein required for posterior embryonic morphogenesis, male tail morphogenesis, commissure formation by VD and DD motor neurons, vulval morphogenesis, and normal locomotion; UNC-62 is orthologous to Drosophila HOMOTHORAX; both maternal-effect unc-62 alleles and the zygotic lethal unc-62(s472) allele phenotypically resemble mutations of the caudal ortholog pal-1; RNAi of the Pbc-class ceh-20 and ceh-40 homeodomain genes strongly enhances the hypomorphic unc-62(e644) allele to give either a strong loss-of-function or null-like phenotype, while overexpression of ceh-20 enhances the lethality of some unc-62 alleles. T28F12.3 T28F12.B;T28F12.3 Protein with strong similarity to C. elegans SOS-1, which is a guanine nucleotide exchange factor in the Ras developmental signaling pathway, contains a pleckstrin homology domain, a ras guanine nucleotide exchange factor (GEF) domain and a RhoGEF domain The sos-1 gene, also known as let-341, encodes an ortholog of Son of sevenless, a guanine nucleotide exchange factor that affects viability, sex myoblast migration, vulval induction, and oogenesis; it acts genetically downstream of let-23 and upstream of let-60 with respect to vulval development. T28F12.F T28F12.1;T28F12.F Protein with moderate similarity to C. elegans Y69A2AR.14 gene product T28F2.1 T28F2.1 Member of an uncharacterized protein family T28F2.2 T28F2.2 Protein of unknown function T28F2.3 T28F2.3 Protein containing a eukaryotic-type carbonic anhydrase domain, which catalyze reversible hydration of carbon dioxide, has low similarity to carbonic anhydrase (human CA3), which hydrates carbon dioxide to generate a proton and a bicarbonate ion carbonic anhydrase; cah-6 encodes a predicted carbonic anhydrase. T28F2.4 T28F2.4 Protein of unknown function T28F2.5 ccb-1;T28F2.5 Protein with high similarity to calcium channel (voltage-dependent, beta 2 subunit) (rat Cacnb2), which is a cardiac L-type calcium channel, member of the dihydropyridine sensitive L-type calcium channel beta subunit family calcium channel subunit; ccb-1 encodes a homolog of the beta subunits of dihydropyridine sensitive L-type calcium channels that, in RNAi screens, is dispensable for viability or grossly normal morphology; a mutant allele of ccb-1 exists, but its phenotype has not yet been described. T28F2.6 T28F2.6 Protein containing a nematode cuticle collagen N-terminal domain, has moderate similarity to a region of type II collagen alpha 1 (human COL2A1), which plays a role in cartilage development and is associated with osteoarthritis and chondrodysplasia cuticular collagen T28F2.7 T28F2.7 Member of the amiloride-sensitive sodium channel family, has similarity to human and D. melanogaster amiloride-sensitive cation channels T28F2.8 T28F2.8 Protein containing a nematode cuticle collagen N-terminal domain, has moderate similarity to a region of type II collagen alpha 1 (human COL2A1), which is involved in cartilage development and is associated with osteoarthritis and chondrodysplasias cuticular collagen T28F3.1 T28F3.1 Protein containing two C2 domains, which may be involved in calcium-dependent phospholipid binding, has moderate similarity to copine III (human CPNE3), which displays protein kinase activity and may play a role in membrane trafficking and C2 domain T28F3.3 T28F3.3 Member of the ZIP zinc transporter family, which may be metal transporters, has high similarity to uncharacterized C. elegans H13N06.5 T28F3.4 T28F3.4 Member of the sugar (and other) transporter family, has weak similarity to solute carrier family 17 member 1 (mouse Slc17a1), which is involved in sodium-dependent phosphate transport and mediates hepatic and renal anion drug transport Sugar (and other) transporters T28F3.5 T28F3.5 Protein containing biotin carboxylase C-terminal, biotin or lipoyl attachment, carboxyl transferase, and carbamoyl-phosphate synthase L chain N-terminal and ATP binding domains, has low similarity to acetyl-coenzyme A carboxylase alpha (rat Acac) Carbamoyl-phosphate synthase (CPSase) (2 domains), Biotin-requiring enzymes, Carboxyl transferase domain; This gene encodes a protein predicted by Eisenberg and coworkers, with 68% accuracy, to be mitochondrial. T28F3.6 T28F3.6 Protein of unknown function T28F3.7 T28F3.7 Protein of unknown function, putative paralog of C. elegans T28F3.8 T28F3.8 T28F3.8 Protein of unknown function, putative paralog of C. elegans T28F3.7 T28F3.9 T28F3.9 Member of the core-2 or I-branching enzyme family, which form blood group I-antigens or side-chains of O-glycans, has a region of weak similarity to human GCNT3, which is a mucin type beta-1 6-N-acetylglucosaminyltransferase T28F4.1 T28F4.1 Protein of unknown function T28F4.2 T28F4.2 Member of the amiloride-sensitive sodium channel family, has similarity to human and D. melanogaster amiloride-sensitive cation channels mechanosensory protein like T28F4.3 T28F4.3 Member of the protein-tyrosine phosphatase family, has a region of moderate similarity to a region of receptor-type protein tyrosine phosphatase epsilon (human PTPRE), which can be cytoplasmic or membrane-spanning and may have a role in brain inflammation protein-tyrosine phosphatase T28F4.4 T28F4.4 Protein of unknown function T28F4.5 T28F4.5 Protein with moderate similarity to C. elegans F54B8.4 The T28F4.5 gene encodes a homolog of Death Associated Protein 1 (DAP-1) protein that may be involved in apoptosis. T28F4.6 T28F4.6 Protein of unknown function T28H10.1 T28H10.1 Member of the 4'-phosphopantetheinyl transferase (holo-acyl carrier protein synthase, ACPS) family, has moderate similarity to uncharacterized C. elegans T04G9.4 B.subtilis SFP protein like T28H10.2 T28H10.2 Putative ortholog of C. elegans C15F1.1 gene product T28H10.3 T28H10.3 Member of the C13 peptidase family of asparaginyl peptidases, has moderate similarity to protease cysteine 1 (legumain, mouse Lgmn), which is a lysosomal cysteine endopeptidase that hydrolyzes asparaginyl bonds vacuolar processing enzyme like T28H11.1 T28H11.1 Protein with weak similarity to human eukaryotic translation initiation factor 3, subunit 8 ( EIF3S8), putative paralog of C. elegans ZC477.1 T28H11.2 T28H11.2 Protein of unknown function, has moderate similarity to C. elegans T28H11.3 7TM chemoreceptor, srm family T28H11.3 T28H11.3 Member of the 7-transmembrane chemoreceptor family of G-protein coupled receptors (GPCR), has moderate similarity to uncharacterized C. elegans T28H11.2 7TM chemoreceptor, srm family T28H11.4 pes-1;T28H11.4 Putative transcription factor of the forkhead family of transcription factors; expressed in early embryogenesis; functions redundantly with FKH-2 T28H11.5 T28H11.5 Protein of unknown function, has low similarity to a region of elastin (mouse Eln), which is a component of the artery extracellular matrix that regulates arterial development and is associated with supravalvular aortic stenosis and congenital cutis laxa T28H11.6 ssp-11;T28H11.6 Member of the MSP, major sperm protein, family T28H11.7 T28H11.7 Member of a protein family T28H11.8 T28H11.8 Protein with low similarity to solute carrier family 17 member 1 (mouse Slc17a1), which is involved in sodium-dependent phosphate transport and mediates hepatic and renal anion drug transport phosphate cotransporter TIM10 tim10 Small zinc finger-like protein TIM9B tim9b Small zinc finger-like protein UNC-48 unc-26;unc-48 Synaptojanin, phosphoinositide phosphatase UNC-83 unc-83 Involved in axon outgrowth and guidance VB0393L.2 VB0393L.2 Protein of unknown function, has strong similarity to C. elegans B0393.8 VC27A7L.1 VC27A7L.1 Member of the 7-transmembrane chemoreceptor family of G-protein coupled receptors (GPCR), has low similarity to C. elegans ODR-10, which is a G protein-coupled receptor involved in odorant response VC5.1 CelDi5;VC5.1 Protein of unknown function VC5.2 VC5.2 Protein with similarity to laminin EGF-like domain VC5.3 VC5.3 Ladder protein npa-1 encodes a large polyprotein precursor that is posttranslationally cleaved to multiple units of ~14.5kDa, each of which is a strong binding protein for fatty acids and retinol (Vitamin A); the lipid binding sites of NPA-1-derived peptides are unusually apolar; NPA-1-derived peptides probably are carrier proteins that enable distribution of these lipids within nematodes; NPA-1-derived peptides are also secreted by parasitic nematode species. VC5.4 VC5.4 Protein with similarity to C2H2-type zinc fingers and to the cullin family VC5.5 VC5.5 Protein with similarity to C4-type zinc fingers VF13D12L.1 VF13D12L.1 Protein with similarity to Spirodela myo-inositol-1-phosphate synthase myo-inisitol-1-phosphate synthase VF13D12L.C VF13D12L.3;VF13D12L.C Member of the malate or L-lactate dehydrogenase family, which are involved in sugar metabolism, has high similarity to uncharacterized C. elegans F36A2.3 VF13D12L.D F13D12.9;VF13D12L.D Protein of unknown function, has weak similarity to C. elegans H14E04.F VF36H2L.1 VF36H2L.1 Protein of unknown function, has low similarity to uncharacterized human DKFZP564D0372 aph-1 encodes an unfamiliar protein predicted to have seven transmembrane domains; APH-1 is a component of the GLP-1/LIN-12 (Notch) pathway, is required maternally for embryonic viability, and also affects morphogenesis, egg laying, germ line proliferation, and translocation of APH-2 to the cell surface; with PEN-2, APH-1 is required for Notch pathway signaling, gamma-secretase cleavage of beta-amyloid precursor protein, and presenilin protein accumulation. VF39H2L.1 VF39H2L.1 Protein with weak similarity to human syntaxin 7 (STX7 ), has weak similarity to C. elegans F36F2.4 VH15N14R.1 VH15N14R.1 Protein of unknown function, has strong similarity to C. elegans Y24F12A.C VM106R.1 VM106R.1 Protein containing a K+ channel tetramerization domain, which facilitate assembly of alpha-subunits into functional tetrameric channels VT23B5.1 VT23B5.1 Protein of unknown function VT23B5.2 VT23B5.2 Protein containing four WD domains (WD-40 repeat), which may mediate protein-protein interactions, a beige or BEACH domain, and a FYVE zinc finger domain, which bind phosphatidylinositol 3-phosphate, has low similarity to a region of human CHS1 FYVE zinc finger; The VT23B5.2 gene encodes a homolog of human CHS, when when mutated leads to Chediak-Higashi syndrome (OMIM:214500). VW02B12L.1 vha-6;VW02B12L.1 Member of the vacuolar H+-ATPase protein family vacuolar ATP synthase VW02B12L.2 VW02B12L.2 Protein with strong similarity to C. elegans F57H12.5 gene product VW02B12L.3 VW02B12L.3 Protein with moderate similarity to microtubule-associated protein RP-EB family member 2 (human MAPRE2), which a cytoskeletal localized protein that may have roles in the cellular defense response, signal transduction, and cell proliferation VW02B12L.4 VW02B12L.4 Protein of unknown function, has strong similarity to C. elegans T17A3.9 VW06B3R.1 VW06B3R.1 Putative ortholog of C. elegans VW06B3R.1 gene product Insulinase (proteinase M16) VZC374L.1 VZC374L.1 Protein with high similarity to mitogen-activated protein kinase kinase 4 (human MAP2K4), which is a putative tumor suppressor involved in the response to cellular stress and apoptosis activation, contains a protein kinase domain serine/threonine kinase VZK822L.1 fat-6;VZK822L.1 Likely stearoyl-CoA delta-9 fatty acid desaturase, specific for long chain (16:0 - 18:0) fatty acids acyl-CoA desaturase; fat-6 encodes a delta-9 fatty acid desaturase that is predicted to be mitochondrial. W01A11.1 W01A11.1 Protein with high similarity to microsomal epoxide hydrolase (human EPHX1), which hydrates reactive epoxides and detoxifies cytochrome p450-generated epoxides during xenobiotic metabolism, member of the alpha or beta hydrolase fold family epoxide hydrolase W01A11.2 W01A11.2 Protein with low similarity to S. cerevisiae Dga1p, which is a diacylglycerol acyltransferase W01A11.3 W01A11.3 Protein with weak similarity to S. cerevisiae IMH1 (Probable coiled-coil protein, single copy and multicopy suppressor of ypt6) W01A11.4 W01A11.4 Member of the galectin family, which are lectins that bind beta galactosides, has low similarity to a region of galectin 8 (rat Lgals8), which interacts with integrins to modulate cell adhesion, migration and apoptosis galaptin (S-lectin); lec-10 encodes a galectin, a soluble galactose-binding lectin; recombinant lec-10 can bind to sugar in an in vitro assay. W01A11.5 W01A11.5 Member of the choline or carnitine o-acyltransferase family, has low similarity to liver carnitine palmitoyltransferase I (rat Cpt1a), which acts in long-chain fatty acid beta-oxidation and influences energy production, cell signaling and apoptosis carnitine palmitoyltransferase W01A11.6 W01A11.6 Protein of unknown function, has moderate similarity to a region of gephyrin (human GPHN), which mediates clustering of inhibitory GABA(A) and glycine receptors (GlyR) at postsynaptic membranes and functions in molybdenum cofactor biosynthesis W01A6.E cul-3;W01A6.E Member of the cullin family of cell cycle control proteins W01A8.1 W01A8.1 Protein of unknown function W01A8.2 W01A8.2 Member of the YggU family, which contains an uncharacterized ACR domain W01A8.3 W01A8.3 Putative cuticulin cuticulin W01A8.4 W01A8.4 Protein of unknown function W01A8.5 W01A8.5 Protein of unknown function W01A8.6 W01A8.6 Member of the metallocarboxypeptidase protein family carboxypeptidase b like W01B11.1 W01B11.1 Protein of unknown function, has weak similarity to C. elegans W03D8.3 W01B11.2 W01B11.2 Member of the sulfate transporter family, contains a sulphate transporter and antisigma factor antagonist (STAS) domain, which may bind NTPs, has low similarity to diastrophic dysplasia sulfate transporter (rat Slc26a2) sulfate transporter W01B11.3 W01B11.3 Protein with high similarity to nucleolar protein 5 (human NOP5), which is a box C+D snoRNP delayed early response protein that may be involved in cell growth regulation, contains a putative snoRNA binding domain W01B11.4 W01B11.4 Protein of unknown function W01B11.5 W01B11.5 Protein of unknown function, has weak similarity to human KIAA0170 protein (Hs.169504, similar to Drosophila photoreceptor cell-specific protein, calphotin) possible trans-splice site at 11908; The protein product of this gene is predicted to contain a glutamine/asparagine (Q/N)-rich ('prion') domain, by the algorithm of Michelitsch and Weissman (as of the WS77 release of WormBase, i.e., in wormpep77). W01B11.6 W01B11.6 Protein with weak similarity to C. elegans Y55F3AR.2 gene product W01B6.1 cwn-2;wnt-2;W01B6.1 Member of the WNT family of secreted proteins WNT-2 precursor; cwn-2 encodes a member of the WNT family; expressed at highest levels in embryos and expression declines and is almost absent by the third larval stage. W01B6.2 W01B6.2 Protein containing a protein kinase domain, has low similarity to casein kinase 1 delta (human CSNK1D), which is a serine-threonine protein kinase involved in DNA repair and may play a role in circadian rhythms serine/threonine kinase W01B6.3 W01B6.3 Member of the multidrug resistance (putative) protein family tetracyclin resistance protein like W01B6.4 W01B6.4 Protein of unknown function, has weak similarity to C. elegans C35D10.11 W01B6.5 W01B6.5 Protein containing a protein kinase domain, has low similarity to hematopoietic cell kinase (mouse Hck), which functions in phagocytosis and interferon gamma (mouse Ifng) signaling in macrophages and may modulate ion transport tyrosine-protein kinase W01B6.6 W01B6.6 Member of the protein-tyrosine phosphatase family, has a region of weak similarity to a region of non-receptor protein tyrosine phosphatase type 2 (human PTPN2), which is involved in human EGFR signaling tyrosine phosphatase W01B6.7 col-2;W01B6.7 Collagen cuticle collagen (CC02); col-2 encodes a member of the collagen superfamily containing collagen triple helix repeats (20 copies); expression peaks during the molt that separates the L2 larval and dauer stages as the dauer cuticle is being formed, and mRNA is expressed at low levels in post-dauer L4 larvae and in adult animals. W01B6.8 W01B6.8 Protein of unknown function, has moderate similarity to C. elegans F35C5.1 W01B6.9 W01B6.9 Protein with weak similarity to human HEC, which is a nuclear protein that inhibits proteolysis of M phase cyclin B, may be involved in chromosome segregation and M phase progression, and is highly expressed in cancer ndc-80 encodes a member of the HEC/Ndc80p family that affects metaphase plate formation in embryos (thus affecting chromosome segregation), kinetochore-microtubule interactions, locomotion, vulval development, body morphology, and embryonic viability; interacts in vivo with KNL-1, HIM-10, and a homolog of Nuf2p, and NDC-80 and HIM-10 are codependent for kinetochore assembly. W01C8.1 W01C8.1 Protein of unknown function W01C8.3 W01C8.3 Protein containing two SET domains, which are involved in protein-protein interactions C. elegans protein C26E6.9; E. coli malate synthase G W01C8.4 W01C8.4 Protein containing a SET domain, which are involved in protein-protein interactions W01C8.5 W01C8.5 Protein of unknown function, has weak similarity to C. elegans H06A10.1 W01C8.6 cat-1;W01C8.6 Vesicular monoamine transporter (VMAT) with similarity to mammalian VMATs synaptic vesicle amine transporter; cat-1 encodes a synaptic vesicular monoamine transporter required for the presence of dopamine and serotonin in nerve terminals, for the normal slowing of worms on a bacterial lawn (versus clean agar), for faster pharyngeal pumping on food, and for a normally (high) rate of egg-laying. W01C9.1 W01C9.1 Protein of unknown function W01C9.2 W01C9.2 Protein of unknown function W01C9.3 W01C9.3 Protein of unknown function, has moderate similarity to C. elegans C09F5.1 The protein product of this gene is predicted to contain a glutamine/asparagine (Q/N)-rich ('prion') domain, by the algorithm of Michelitsch and Weissman (as of the WS77 release of WormBase, i.e., in wormpep77). W01C9.4 W01C9.4 Putative Delta(2),Delta(4)-dienoyl-CoA reductase 2,4-dienoyl-CoA reductase; This gene encodes a protein predicted by Eisenberg and coworkers, with 68% accuracy, to be mitochondrial. W01C9.5 W01C9.5 Protein of unknown function, has weak similarity to C. elegans Y17G7B.6 Globin W01D2.1 W01D2.1 Protein with very strong similarity to C. elegans RPL-37, which is involved in meiosis, embryogenesis, and morphogenesis, member of the ribosomal L37e family, which are part of the large ribosomal subunit ribosomal protein L37 W01D2.2 nhr-61;W01D2.2 Member of the nuclear hormone receptor/Zinc finger protein family Zinc finger, C4 type (two domains) W01D2.3 W01D2.3 Protein of unknown function W01D2.4 W01D2.4 Protein containing a DUF32 domain of unknown function, has high similarity to uncharacterized C. elegans C50H11.4 W01D2.5 W01D2.5 Protein of unknown function, has moderate similarity to C. elegans C01B12.4 W01F3.1 W01F3.1 Protein of unknown function W01F3.2 W01F3.2 Protein with moderate similarity to C. elegans C31B8.8 (Putative matrix metalloprotease) W01F3.3 W01F3.3 Protein containing ten kunitz or bovine pancreatic trypsin inhibitor domains and one thyroglobulin type-1 repeat, has a region of low similarity to tissue factor pathway inhibitor (human TFPI), which is a protease inhibitor Kunitz/Bovine pancreatic trypsin inhibitor domain (10 domains), Thyroglobulin type-1 repeat W01G7.1 W01G7.1 Protein of unknown function, has weak similarity to C. elegans H20J04_865.B daf-5 encodes a proline-rich protein, conserved in C. briggsae but not observed in non-nematode genomes, that promotes dauer formation in the group II branch of the dauer pathway, may regulate chemosensation via AWC neurons, and may regulate egg laying; daf-5 mutations suppress the dauer phenotype of group II Daf-c mutants; daf-5(e1385) partially suppresses dauer formation by aex-6(sa699) mutants at 26.8 degrees C. W01G7.3 W01G7.3 Putative subunit of RNA polymerase II RNA polymerases L / 13 to 16 Kd subunit W01G7.4 W01G7.4 Protein of unknown function W01G7.5 lem-2;Ce-MAN1;W01G7.5 Integral membrane LEM (LAP2-emerin-MAN1) domain-containing protein with similarity to MAN1 W01H2.1 W01H2.1 Protein of unknown function W01H2.2 W01H2.2 Protein of unknown function W01H2.3 W01H2.3 Protein with high similarity to Ras-related GTP-binding protein 26 (rat Rab26), which is a GTP-binding protein and putative GTPase that may be involved in vesicle exocytosis, member of the Ras superfamily of GTP binding proteins GTP-binding protein W02A11.1 W02A11.1 Protein with moderate similarity to S. pombe Cpd1p, which is a subunit of the DNA polymerase delta holoenzyme complex W02A11.2 W02A11.2 Protein with low similarity to S. cerevisiae Vps25p, which is required for normal mating efficiency, pseudohyphal growth, and resistance to NaCL, KCl, and H2O2 W02A11.3 W02A11.3 Protein containing a C3HC4 type (RING) zinc finger, which may mediate protein-protein interactions, has a region of moderate similarity to a region of RING finger protein 12 (mouse Rnf12), which is a corepressor of LIM that binds to LIM domains Zinc finger, C3HC4 type (RING finger) W02A11.4 W02A11.4 Member of the UBA-THIF-type NAD-FAD binding fold family, contains 2 repeat in ubiquitin-activating (UBA) protein domains, has high similarity to a region of SUMO-1 activating enzyme subunit 2 (human UBA2), which is involved in the activation of human UBL1 ThiF family; uba-2 encodes the C. elegans ortholog of Saccharomyces cerevisiae Uba2p and human ubiquitin-like 2 activating enzyme E1B; by homology, UBA-2 is predicted to form, with a regulatory subunit, AOS-1, a heterodimeric enzyme that activates the ubiquitin-like protein SMO-1/SUMO in preparation for its covalent attachment to target proteins to regulate their subcellular localization and/or stability; in C. elegans, UBA-2 is required for embryogenesis and vulval development, as well as for proper Hox gene regulation; uba-2/aos-1(RNAi) animals that survive embryogenesis show ectopic expression of EGL-5 and ectopic anterior sensory ray formation. W02A11.5 W02A11.5 Protein with moderate similarity to C. elegans W02A11.8 BTB (also known as BR-C/Ttk) domain. W02A11.8 W02A11.8 Protein containing a BTB (BR-C, ttk and babor) or POZ (Pox virus and zinc finger) domain, which are found in some DNA and actin binding proteins and may mediate protein-protein interactions, has moderate similarity to uncharacterized C. elegans F59H6.11 BTB (also known as BR-C/Ttk) domain. W02A2.2 W02A2.B;W02A2.2 Member of an uncharacterized protein family W02A2.3 W02A2.C;W02A2.3 Protein containing a chitin binding peritrophin-A domain, which contain six conserved cysteines that probably form three disulphide bridges The protein product of this gene is predicted to contain a glutamine/asparagine (Q/N)-rich ('prion') domain, by the algorithm of Michelitsch and Weissman (as of the WS77 release of WormBase, i.e., in wormpep77). W02A2.4 W02A2.D;W02A2.4 Protein containing a protein kinase domain, has low similarity to fer (fps/fes related) tyrosine kinase (mouse Fert2), which may mediate cell-cell signaling and may play roles in cell size-dependent cytoskeletal reorganization W02A2.5 W02A2.E;W02A2.5 Member of the uncharacterized protein family UPF0057, contains a ligand-gated ion channel domain, which are found in ionotropic glutamate receptors and NMDA receptors W02A2.6 rec-8;W02A2.F;W02A2.6 Sister chromatid cohesion protein that functions during meiosis rec-8 encodes a meiosis-specific cohesin complex subunit orthologous to Saccharomyces cerevisiae and Schizosaccharomyces pombe Rec8p; REC-8 is essential for pairing of homologoues and sister chromatids during meiosis and thus for proper chromosome disjunction; in the germline, REC-8 associates with chromatin of transition zone nuclei, and co-localizes with SMC-1 along the longitudinal axes of synapsed chromosomes at pachytene and in a cruciform pattern at diakinesis; REC-8 localization to chromatin is dependent upon TIM-1, a HEAT/Armadillo repeat-containing protein related to Drosophila TIMELESS, and additionally, REC-8 and SCC-3 are mutually required for chromatin localization; REC-8 cleavage and degradation during meiosis I is dependent on the AIR-2 aurora-like kinase and during meiosis II on AIR-2 and the PLK-1 polo-like kinase. W02A2.A fat-2;W02A2.1;W02A2.A Delta-12-fatty acid desaturase W02A2.G mex-5;W02A2.7;W02A2.G Zinc finger protein that is required and apparently sufficient for the repression of the expression of germline-specific proteins in the anterior of embryos W02A2.H W02A2.8;W02A2.H Protein of unknown function W02B12.1 W02B12.1 Member of the lipase or acylhydrolase family, has moderate similarity to a region of intestinal phospholipase B-lipase (rat PLB-LIP), which displays phospholipase A2, lysophospholipase, and triacylglycerol lipase activities phospholipase W02B12.10 W02B12.10 Putative methyltransferase, putative ortholog of human METTL1 and S. cerevisiae Ydl201p This gene encodes a protein predicted by Eisenberg and coworkers, with 52% accuracy, to be mitochondrial. W02B12.11 W02B12.11 Putative N-acetyllactosamine synthase n-acetyllactosamine synthase W02B12.12 W02B12.12 Protein containing a protein kinase domainhas low similarity to serine threonine kinase 22A (testis-specific serine kinase 1, mouse Stk22a), which is a putative testis-specific serine-threonine protein kinase that may play a role in spermatid development serine/threonine kinase W02B12.2 rsp-2;srp-4;CeSRp40;W02B12.2 SR protein involved in mRNA splicing pre-mRNA splicing factor like protein W02B12.3 rsp-1;srp-5;CeSRp75;W02B12.3 SR protein involved in mRNA splicing pre-mRNA splicing factor like protein W02B12.4 W02B12.4 Putative carboxylesterase, has strong similarity to C. elegans GES-1 esterase W02B12.6 W02B12.6 Member of the class II alanyl (A)-tRNA synthetase family, has moderate similarity to alanyl-tRNA synthetase (human AARS), which aminoacylates tRNA with alanine for protein biosynthesis and acts as an autoantigen in patients with polymyositis alanyl-tRNA synthetase; This gene encodes a protein predicted by Eisenberg and coworkers, with 52% accuracy, to be mitochondrial. W02B12.7 klp-17;W02B12.7 C-terminal motor kinesin that is involved in chromosome movement during early embryonic and germ line development kinesin, kinesin-14 family W02B12.8 W02B12.8 Protein containing a RhoGAP (GTPase activator protein) domain, has moderate similarity to rho GTPase activating protein 1 (human ARHGAP1), which is a GTPase activating protein for CDC42, rho (RHOA) and rac proteins and inhibits rho mediated responses GTPase-activating (rhoGAP) like protein W02B12.9 W02B12.9 Member of the mitochondrial carrier protein family of membrane transporters, has moderate similarity to mitochondrial RNA splicing protein 3 (S. cerevisiae Mrs3p) mitochondrial RNA splicing MSR4 like protein W02B3.2 W02B3.2 Putative G protein-coupled receptor kinase with strong similarity to G protein-coupled receptor kinases of human and Drosophila G-protein coupled receptor W02B3.3 W02B3.3 Protein of unknown function W02B3.4 W02B3.4 Protein of unknown function, has a region of low similarity to a region of Fukuyama type congenital muscular dystrophy (human FCMD), which acts in neuronal migration and brain and muscle development and is associated with Fukuyama-type muscular dystrophy W02B3.5 W02B3.5 Protein with strong similarity to C. elegans W02B3.4 gene product W02B3.6 W02B3.6 Protein containing four GLTT repeat region domains W02B3.7 W02B3.7 Protein of unknown function, has moderate similarity to C. elegans W02B3.4 W02B8.1 W02B8.1 Protein of unknown function W02B8.2 W02B8.2 Putative coiled-coil protein, contains a putative CHN (NIK1-like kinase) domain, has similarity to human a centromere protein CENPE Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2 W02B8.3 W02B8.3 Member of an uncharacterized protein family W02B8.4 W02B8.4 Putative paralog of C. elegans W02B8.3 gene product W02B9.1 hmr-1;ZK39.1;Y52B11B.2;W02B9.1 Two cadherin isoforms; HMR-1A required for epithelial morphogenesis and HMR-1B required for axonal guidance cadherin; hmr-1 encodes two isoforms of a classical cadherin that contain extracellular cadherin, EGF-like, and laminin G domains as well as a highly conserved intracellular domain that binds beta-catenin; by homology, the HMR-1 proteins are predicted to function as calcium-dependent, homophilic cell-cell adhesion receptors; in vivo, HMR-1A activity is required for mediating the cell migrations, cell shape changes, and presumably actin cytoskeleton rearrangements that occur during embryonic morphogenesis; HMR-1B is required for fasciculation and outgrowth of a subset of motor neuron processes; HMR-1 antibodies detect expression in all embryonic blastomeres at early stages of development but as hypodermal adherens junctions form and morphogenesis begins, HMR-1 becomes highly expressed in the apical junctions of all hypodermal cells; later, HMR-1 is expressed primarily at the apical margins of hypodermal, pharyngeal, and intestinal cells in a pattern consistent with localization to adherens junctions; an HMR-1B reporter fusion is expressed in neurons, including the DD, VD, and AS class of motor neurons; HMR-1 activity is required for proper localization of other junctional components, such as HMP-1/alpha-catenin and HMP-2/beta-catenin, but not for localization of AJM-1, the junctional component recognized by the MH27 antibody. | hmr-1 encodes two isoforms of a classical cadherin that contain extracellular cadherin, EGF-like, and laminin G domains as well as a highly conserved intracellular domain that binds beta-catenin; by homology, the HMR-1 proteins are predicted to function as a calcium-dependent, homophilic cell-cell adhesion receptor; in vivo, HMR-1A activity is required for mediating the cell migrations, cell shape changes, and presumably actin cytoskeleton rearrangements that occur during embryonic morphogenesis; HMR-1B is required for fasciculation and outgrowth of a subset of motor neuron processes; HMR-1 antibodies detect expression in all embryonic blastomeres at early stages of development but as hypodermal adherens junctions form and morphogenesis begins, HMR-1 becomes highly expressed in the apical junctions of all hypodermal cells; later, HMR-1 is expressed primarily at the apical margins of hypodermal, pharyngeal, and intestinal cells in a pattern consistent with localization to adherens junctions; an HMR-1B reporter fusion is expressed in neurons, including the DD, VD, and AS class of motor neurons; HMR-1 activity is required for proper localization of other junctional components, such as HMP-1/alpha-catenin and HMP-2/beta-catenin, but not for localization of AJM-1, the junctional component recognized by the MH27 antibody. W02C12.1 W02C12.1 Protein containing twelve epidermal growth factor (EGF)-like domains, one hyalin repeat (HYR) domain, which may be involved in cell adhesion, has a region of moderate similarity to a region of rat Notch2, which is involved in cell fate determination EGF-like protein W02C12.2 W02C12.2 Protein of unknown function W02C12.3 W02C12.3 Protein containing a helix-loop-helix DNA-binding domain, which mediate protein dimerization, has a region of moderate similarity to a region of microphthalmia-associated transcription factor (mouse Mitf), which is a transcription factor transcription factor W02D3.1 W02D3.1 Member of the cytochrome b-like protein family cytochrome B5 W02D3.10 W02D3.10 Protein of unknown function W02D3.11 W02D3.11 Putative ortholog of C. elegans F08B6.D gene product W02D3.11 encodes, by alternative splicing, two protein isoforms orthologous to human hnRNP F and hnRNP H proteins, which activate alternative mRNA splicing in neurons; W02D3.11A-B proteins localize to nuclear speckles thought to represent foci of pre-mRNA; with EXC-7 and UNC-75, W02D3.11A-B may act as pre-mRNA splicing factors. W02D3.2 W02D3.2 Protein with high similarity to dihydroorotate dehydrogenase (human DHODH), which catalyzes the fourth step in de novo pyrimidine biosynthesis whereby dihydroorotate is converted to orotate, member of the dihydroorotate dehydrogenase family dihydroorotate dehydrogenase W02D3.3 W02D3.3 Protein with similarity to human paraoxonases (arylesterases) paraoxonase/arylesterase; mec-6 is homologous to the human PARAOXONASE 1 gene (PON1, OMIM:168820), which in some allelic forms is associated with susceptibility to coronary artery disease; MEC-6 protein interacts physically with the MEC-4 degenerin ion channel, is colocalized with it in vivo, and is required for MEC-4 punctate expression along touch-receptor neural processes. W02D3.4 W02D3.4 Protein of unknown function, has moderate similarity to uncharacterized human FLJ11155 W02D3.5 lbp-6;W02D3.5 Protein with high similarity to C. elegans LBP-5, which is involved in locomotory behavior, member of the lipocalin and cytosolic fatty-acid binding protein family fatty acid-binding protein W02D3.6 W02D3.6 Protein with high similarity to heart-skeletal muscle adenine nucleotide translocator (mouse Slc25a4), which functions in heart and brain metabolism and induces apoptosis, member of the mitochondrial carrier protein family of membrane transporters ADP, ATP carrier protein W02D3.7 lbp-5;W02D3.7 Member of the fatty acid-binding protein family fatty acid-binding protein; lbp-5 encodes a predicted intracellular fatty acid binding protein (iFABP) that is most similar to the vertebrate muscle and heart FABPs; by homology, LBP-5 is predicted to function as an intracellular transporter for small hydrophobic molecules such as lipids and steroid hormones; loss of lbp-5 activity via large-scale RNAi screens indicates that, in C. elegans, LBP-5 is required for movement. W02D3.8 smg-5;mab-15;W02D3.8 Protein involved in nonsense-mediated mRNA decay, RNAi-mediated inhibition of gene expression W02D3.9 unc-37;let-76;ESG;W02D3.9 Transcription factor involved in regulation of body size, vulval and gonadal development; possible ortholog of Drosophila GROUCHO and human TLE4 transducin-like enhancer protein; The unc-37 gene encodes a transducin-like WD-repeat protein homologous to Drosophila GROUCHO that genetically interacts with components of the transcriptional Mediator complex. W02D7.10 W02D7.10 Protein of unknown function W02D7.2 W02D7.2 Member of the C-type lectin family W02D7.3 W02D7.3 Protein of unknown function W02D7.4 W02D7.4 Member of a protein family W02D7.5 W02D7.5 Member of an uncharacterized protein family W02D7.6 W02D7.6 Protein containing three C2H2 type zinc finger domains, which bind nucleic acids W02D7.7 sel-9;W02D7.7 Member of the p24 family of type I membrane proteins, involved in negative regulation of LIN-12 and GLP-1 activity type I membrane protein; sel-9 encodes a member of the p24 family of proteins that affects growth and locomotion and likely functions to negatively regulate the transport of lin-12 and glp-1 to the cell surface; genetically interacts with mutations in lin-12 that affect the extracellular domain with respect to egg laying, AC/VU fate decision, and vulval formation and interacts with glp-1 mutations with respect to proximal proliferation of the germline and embryonic viability. W02D7.8 W02D7.8 Protein of unknown function W02D7.9 W02D7.9 Protein of unknown function W02D9.1 W02D9.1 Putative DNA polymerase alpha primase subunit C, possible ortholog of human DNA primase PRIM2A, Hs.74519 DNA primase 58 KD subunit; pri-2 encodes a homolog of the DNA polymerase alpha-primase subunit C that is required in embryos for the normal timing of embryonic cell divisions (much as DIV-1 is) and for normal mitosis in the germline. W02D9.10 W02D9.10 Protein of unknown function, has strong similarity to C. elegans F31D4.8 W02D9.2 W02D9.2 Protein of unknown function, has a region of low similarity to a region of S. cerevisiae Yip1p, which is involved in vesicular transport and interacts with the transport GTPases S. cerevisiae Ypt1p and S. cerevisiae Ypt31p at the Golgi membrane Yeast YIP1 protein like W02D9.3 W02D9.3 Protein with a putative HMG (high mobility group) box, has weak similarity to C. elegans members of the DNA replication related (tentative) protein family high mobility group protein like W02D9.4 W02D9.4 Protein of unknown function, has strong similarity to C. elegans ZK154.5 W02D9.5 W02D9.5 Protein containing a major sperm protein (MSP) domain, which are involved in sperm motility, has high similarity to uncharacterized C. elegans K07F5.9 W02D9.6 W02D9.6 Protein of unknown function W02D9.7 W02D9.7 Protein of unknown function W02D9.8 W02D9.8 Protein of unknown function W02D9.9 W02D9.9 Protein of unknown function W02F12.2 W02F12.2 Protein with weak similarity to S. cerevisiae YPL087W W02F12.3 W02F12.3 Protein of unknown function W02F12.4 W02F12.4 Protein of unknown function W02F12.5 W02F12.5 Protein containing a 2-oxo acid dehydrogenases acyltransferase catalytic domain and a biotin or lipoyl attachment domain, has low similarity to dihydrolipoamidedehydrogenase-binding protein (protein X, human PDX1) dihydrolipoamide succinyltransferase; This gene encodes a protein predicted by Eisenberg and coworkers, with 68% accuracy, to be mitochondrial. W02F12.6 W02F12.6 Protein of unknown function, has weak similarity to C. elegans T13B5.8 W02F12.7 W02F12.7 Member of the C. elegans Srg family of integral membrane proteins, has low similarity to C. elegans SRG-9, which is a G protein-coupled receptor that may be involved in chemosensation by sensory amphid neurons 7TM chemoreceptor, srg family W02G9.1 W02G9.1 Protein with strong similarity to S. cerevisiae Ysa1p, a nucleoside diphosphate-sugar hydrolase ndx-2 encodes a NUDIX hydrolase; by sequence comparison, NDX-2 is predicted to be orthologous to human NUDT5 which, in vitro, possesses ADP-sugar diphosphatase activity; in C. elegans, loss of ndx-2 activity via RNA-mediated interference (RNAi) does not result in any obvious abnormalities, consistent with the proposed nonessential roles for Nudix proteins in eliminating potentially toxic nucleotide metabolites from cells and modulating levels of metabolic intermediates by shuttling them into alternative biochemical pathways. W02G9.2 W02G9.2 Protein containing six Kelch motif domains and a BTB (BR-C, ttk and babor) or POZ (Pox virus and zinc finger) domain, has low similarity to kelch-like 2 (Mayven) (human KLHL2), which is a protein-binding protein and putative transporter W02G9.3 W02G9.3 Protein containing a thiouridine synthase, methylase or pseudouridine synthase (THUMP) domain, which may bind RNA W02G9.4 W02G9.4 Protein containing two CUB domains, has low similarity to a region of cubilin (human CUBN), which is a receptor for vitamin B12 and intrinsic factor, mediates high density lipoprotein endocytosis, and is associated with hereditary megaloblastic anemia 1 W02G9.5 W02G9.5 Protein of unknown function, has low similarity to a region of S. cerevisiae Ccr4p, which is a component of the CCR4 transcriptional complex and a component of the major cytoplasmic mRNA deadenylase W02H3.1 W02H3.1 Protein of unknown function W02H3.2 W02H3.2 Protein with strong similarity to C. elegans C01H6.9 gene product W02H5.1 W02H5.1 Protein with strong similarity to C. elegans W02H5.M gene product W02H5.2 W02H5.2 Putative ortholog of C. elegans W02H5.J gene product W02H5.3 W02H5.3 Putative ortholog of C. elegans Y60A3.Q gene product W02H5.4 W02H5.4 Putative ortholog of C. elegans Y60A3.Q gene product W02H5.5 W02H5.5 Protein with strong similarity to C. elegans W02H5.D gene product W02H5.6 W02H5.6 Putative ortholog of C. elegans W02H5.C gene product 7TM chemoreceptor, srh family W02H5.7 W02H5.7 Putative ortholog of C. elegans W02H5.B gene product W02H5.8 W02H5.8 Putative ortholog of C. elegans W02H5.A gene product W03A3.1 ceh-10;W03A3.1 Homeodomain transcription factor expressed in many neuronal cells; has similarity over the homeodomain to many human and D. melanogaster homeodomain transcription factors ceh-10 encodes a member of the Paired-like class of homeodomain proteins; the CEH-10 homeodomain is closely related to the homeodomains of two vertebrate retina proteins (Chx10 from mice and Vsx-1 from goldfish); ceh-10 is required for CAN cell fate specification and migration, complete loss of ceh-10 function results in failure of CAN cell migration and loss of expression of CEH-23 and CEH-10 itself in the CAN and AIY interneurons; CEH-10, along with TTX-3 and CEH-23, constitutes a regulatory cascade of transcription factors that controls all sub-type specific features of the AIY interneurons. W03A3.2 mus-1;W03A3.2 Protein with strong similarity to prokaryotic DNA polymerase I and to D. melanogaster deoxyribonuclease MUS308 (mutagen sensitive) DNA polymerase; This gene encodes a protein predicted by Eisenberg and coworkers, with 52% accuracy, to be mitochondrial. W03A3.3 W03A3.3 Member of the DEAD or DEAH box ATP-dependent RNA helicase family and contains a helicase conserved C-terminal domain, has low similarity to a region of mouse U5-200-KD, which is an RNA unwindase and subunit of U5 small nuclear ribonucleoprotein (snRNP) W03A5.1 W03A5.1 Protein containing a protein kinase domain and a Src homology 3 (SH3) domain, which bind proline-rich peptides, has a region of low similarity to a region of fyn-related kinase (human FRK), which is involved in cell proliferation control W03A5.2 W03A5.2 Protein of unknown function, 58 amino acids near C-terminus are virtually identical to N-terminus of C. elegans C50E10.2 W03A5.2 is orthologous to the human gene UNKNOWN (PROTEIN FOR MGC:19580) (GGCX; OMIM:137167), which when mutated leads to disease. W03A5.3 W03A5.3 Protein of unknown function, has weak similarity to C. elegans T24A6.18, contains one ground-like (grl) domain grl-22 encodes a hedgehog-related protein with low sequence similarity to the ground-like domain. W03A5.4 W03A5.4 Protein of unknown function, has weak to moderate similarity to H. sapiens DLGAP1 and DLGAP2 gene products W03A5.5 W03A5.5 Protein of unknown function W03A5.6 W03A5.6 Protein of unknown function W03A5.7 W03A5.7 Protein with similarity to DNAJ domain This gene encodes a protein containing a DnaJ ('J') domain. W03B1.1 W03B1.1 Protein with strong similarity to C. elegans C08F11.10 gene product W03B1.2 W03B1.2 Protein of unknown function, has high similarity to uncharacterized C. elegans Y38C1AB.6 W03B1.3 W03B1.3 Protein of unknown function, has high similarity to uncharacterized C. elegans C08F11.10 W03B1.4 srs-1;W03B1.4;SerRS Protein containing a tRNA synthetase class II core domain (G, H, P, S and T), which is the catalytic domain, has low similarity to S. cerevisiae Ses1p, which is a cytoplasmic seryl-tRNA synthetase that is involved in seryl-tRNA aminoacylation srs-1 encodes a predicted mitochondrial seryl-tRNA synthetase (SerRS), a class II aminoacyl-tRNA synthetase that catalyzes the attachment of serine to its cognate tRNA and is thus required for protein biosynthesis; in C. elegans, SRS-1 activity is required for normal postembryonic morphology and rates of growth. W03B1.5 W03B1.5 Protein of unknown function, has very strong similarity to uncharacterized C. elegans W03B1.9 W03B1.6 W03B1.6 Protein of unknown function, putative paralog of C. elegans F37C4.1 W03B1.7 W03B1.7 Protein containing a DUF33 domain of unknown function W03B1.8 W03B1.8 Protein containing a DUF33 domain of unknown function, has high similarity to uncharacterized C. elegans F37C4.2 W03B1.9 W03B1.9 Protein of unknown function, has very strong similarity to uncharacterized C. elegans W03B1.5 W03C9.1 W03C9.1 Protein of unknown function W03C9.2 W03C9.2 Protein of unknown function W03C9.3 Ce-rab7;W03C9.3 Protein with high similarity to Ras-related GTP-binding protein 7 (rat Rab7), which is involved in vesicle transport and may play a role in actin organization and bone formation, member of the Ras superfamily of GTP-binding proteins ras related protein; rab-7 encodes a small GTPase homologous to the Rab GTPases that function in endocytosis, membrane fusion, and vesicular trafficking events; RAB-7 is required for proper yolk protein localization in oocytes, and for embryogenesis, locomotion, and normal body morphology; by sequence similarity, RAB-7 is predicted to be a late endosome component. W03C9.4 lin-29;egl-29;Y17G7A.2;W03C9.4 Transcription factor involved in terminal differentiation of cells transcription factor lin-29; lin-29 encodes a zinc finger transcription factor of the C2H2 type that affects the heterochronic development of the vulva, egg laying system, cuticle, and the molting cycle; expressed in uterine and vulval muscle cells, seam cells, pharynx, head neurons, ventral cord neurons, preanal ganglion, distal tip cells, anchor cell, vulval cells, and cells in the tail. W03C9.5 W03C9.5 Protein of unknown function W03C9.6 W03C9.6 Member of the multidrug resistance (putative) protein family W03C9.7 mex-1;W03C9.7 Highly conserved germline protein among eukaryotes; required for differentiation of some cell lineages; contains a C-X8-C-X5-C-X3-H-type zinc finger domain Zinc finger C-x8-C-x5-C-x3-H type (and similar). (2 domains); The mex-1 gene encodes a CCCH-type zinc-finger protein that is required maternally for segregation of P granules, germ cell formation, and somatic cell differentiation in the early embryo; mex-1 is expressed cytoplasmically in germ line blastomeres and is required for restricting PIE-1 expression and function to these cells; mex-1 RNA is also found transiently in association with P granules. W03D2.1 W03D2.1 Protein of unknown function, has a region of moderate similarity to a region of carboxyl ester lipase (human CEL), which is an enzyme that hydrolyzes cholesterol and other dietary esters and is involved in the intestinal absorption of dietary lipids The protein product of this gene is predicted to contain a glutamine/asparagine (Q/N)-rich ('prion') domain, by the algorithm of Michelitsch and Weissman (as of the WS77 release of WormBase, i.e., in wormpep77). W03D2.10 W03D2.10 Member of the 7-transmembrane chemoreceptor family of G-protein coupled receptors (GPCR), has low similarity to C. elegans ODR-10, which is a G protein-coupled receptor involved in odorant response 7TM chemoreceptor, str family W03D2.2 W03D2.2 Protein containing an F-box domain, which serve as a link between a target protein and a ubiquitin-conjugating enzyme This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins. W03D2.3 W03D2.3 Protein of unknown function W03D2.4 W03D2.4 Protein with high similarity to proliferating cell nuclear antigen (human PCNA), which is a processivity factor involved in DNA replication, DNA repair, and cell cycle progression, contains proliferating cell nuclear antigen N- and C-terminal domains cyclin; pcn-1 encodes the C. elegans ortholog of proliferating cell nuclear antigen (PCNA), an acidic protein that is an essential component of the DNA replication and repair machinery and serves as a processivity factor for DNA polymerase delta; PCN-1 is required for early embryogenesis and for proper germ-line development, and directly interacts with CKI-2, a cyclin-dependent kinase inhibitor homolog that may be required for cell cycle progression during embryogenesis, and with ATL-1/PI3K, KIN-20, MRT-2/RAD1, and RFC-1, proteins that all play a role in the DNA damage checkpoint pathway; PCN-1 is highly expressed in ovaries and developing embryos. W03D2.5 wrt-5;W03D2.5 Protein of unknown function, contains a Wart domain wrt-5 encodes a predicted secreted protein that, in C. elegans, comprises one of ten members of the warthog gene family; by homology, WRT-5 is predicted to be involved in cell communication, but as loss of wrt-5 activity via RNA-mediated interference (RNAi) does not result in any obvious abnormalities, the precise role of WRT-5 in C. elegans development and/or behavior is not yet known; a wrt-5 reporter gene is expressed in all seam cells and the excretory cell from the beginning of embryonic morphogenesis to the adult stage, in the six cells of the pharyngeal intestinal valve and rectal valve in larvae and adults, and in the gonadal sheath cells, spermathecal sheath cells, and uterus in adults. W03D2.6 W03D2.6 Protein of unknown function, has low similarity to uncharacterized C. elegans R07C12.3 W03D2.7 W03D2.7 Protein with moderate similarity to C. elegans C45G7.2 W03D2.8 W03D2.8 Protein of unknown function, has weak similarity to C. elegans C52A10.3 W03D2.9 W03D2.9 Protein of unknown function, has weak similarity to C. elegans C10F3.6 W03D8.1 W03D8.1 Protein of unknown function, has similarity to C. elegans Y71F9A_291.B W03D8.10 W03D8.10 Protein of unknown function, has high similarity to uncharacterized C. elegans W03D8.9 W03D8.2 W03D8.2 Member of the serine or threonine protein phosphatase family, has moderate similarity to S. pombe Sds21p, which is a serine-threonine protein phosphatase involved in mitotic chromosome segregation ser/thr protein phosphatase W03D8.3 W03D8.3 Protein of unknown function, has high similarity to uncharacterized C. elegans W01B11.1 W03D8.4 pop-1;W03D8.4 TCF-like HMG-box DNA-binding domain transcription factor; required for Wnt signaling and interpretation of anteroposterior polarity throughout embryogenesis and larval development W03D8.5 W03D8.5 Protein containing a major sperm protein (MSP) domain, which are involved in sperm motility W03D8.6 W03D8.6 Protein with similarity to human and D. melanogaster neurexins, involved in neuronal development; has weak similarity to human SLI (slit) homologs, which are also involved in neuronal development itx-1 encodes one of two Caspr orthologues found in the C. elegans genome; Caspr proteins belong to the Neurexin superfamily and are involved in mediating cell-cell contacts and in the formation of specialized membrane-domains in polarized epithelial and nerve cells; RNA interference of itx-1 suggests that itx-1 is involved in the correct positioning and maintenance of apical junctions and in maintaining epithelial integrity in the gut; gfp-reporter studies indicate that ITX-1 is expressed in intestinal cell epithelia and in the socket cells of the inner and outer labial sensilla; immunofluorescence studies indicate that ITX-1 localizes to the baso-lateral membranes of intestinal epithelia. W03D8.7 W03D8.7 Protein of unknown function, putative paralog of C. elegans C25G4.8 W03D8.8 W03D8.8 Putative acyl-CoA thioesterase W03D8.9 W03D8.9 Protein of unknown function, has strong similarity to uncharacterized C. elegans Y37D8A.5 W03F11.2 gcy-17;gcy-24;W03F11.2 Protein containing three protein kinase domains, two receptor family ligand binding domains, and an adenylate and guanylate cyclase catalytic domain, has low similarity to guanylyl cyclase G (rat Rn.10198) gcy-17 encodes a predicted guanylate cyclase. W03F11.5 W03F11.5 Protein of unknown function, has weak similarity to C. elegans W03D8.5 W03F8.1 W03F8.1 Member of the troponin family, which regulate calcium-induced muscle contraction, has high similarity to uncharacterized C. elegans T20B3.2 troponin W03F8.2 W03F8.2 Protein containing two Src homology 2 (SH2) domains, which are regulatory modules of intracellular signaling, and a protein kinase domain, has a region of low similarity to a region of human FER, which is a human FES related tyrosine kinase protein kinase W03F8.3 W03F8.3 Protein containing a peptidyl-tRNA hydrolase domain, which contain peptidyl-tRNA hydrolase activity, has low similarity to mitochondrial translational release factor 1 (human MTRF1), which may play a role in regulating translational termination protein releasing factor; This gene encodes a protein predicted by Eisenberg and coworkers, with 68% accuracy, to be mitochondrial. W03F8.4 W03F8.4 Protein of unknown function, has low similarity to uncharacterized human LOC51002 W03F8.5 lam-1;W03F8.5 Member of the laminin protein family laminin; lam-1 encodes a laminin beta that affects degenerin-induced cell death and is required redundantly with lam-2 for morphogenesis. W03F8.6 W03F8.6 Protein of unknown function, has weak similarity to C. elegans F55C12.3; may be anchored to the membrane of a secretory vesicle or the Golgi apparatus W03F8.8 W03F8.8 Protein of unknown function W03F8.9 W03F8.9 Protein with weak similarity to guanine nucleotide-binding protein alpha subunits (GPA) W03F9.10 W03F9.10 Protein of unknown function, has high similarity to a region of splicing factor 3b, subunit 2 (spliceosome associated protein 145, human SF3B2), which is part of a complex that binds pre-mRNA upstream of the branchpoint and interacts with HSV IE63 protein W03F9.2 W03F9.2 Protein of unknown function, has weak similarity to C. elegans C29E4.6 W03F9.3 W03F9.3 Protein with strong similarity to C. elegans Y32G9A.3 gene product W03F9.4 W03F9.4 Member of the choline or carnitine o-acyltransferase family, has moderate similarity to liver carnitine palmitoyltransferase I (rat Cpt1a), which acts in long-chain fatty acid beta-oxidation and influences energy production, cell signaling and apoptosis acetyltransferase W03F9.5 ttb-1;CeTFIIB;W03F9.5 Component of the RNA polymerase complex with moderate similarity to Drosophila TFIIB transcription factor W03F9.6 W03F9.6 Member of the 7-transmembrane chemoreceptor family of G-protein coupled receptors (GPCR), has high similarity to uncharacterized C. elegans C44C3.9 7TM chemoreceptor, srh family W03F9.9 W03F9.9 Member of the short-chain dehydrogenase-reductase family, which are NAD- or NADP-dependent oxidoreductases, has low similarity to rat Pecr, which is a peroxisomal trans 2-enoyl CoA reductase that catalyzes the reduction of trans 2-enoyl CoAs glucose 1-deydrogenase; This gene encodes a protein predicted by Eisenberg and coworkers, with 68% accuracy, to be mitochondrial. W03G1.1 W03G1.1 Member of the sodium:dicarboxylate symporter family of membrane transporters, has moderate similarity to C. elegans GLT-2, which is a glutamate transporter amino acid transporter W03G1.2 W03G1.2 Protein of unknown function, putative paralog of C. elegans Y52D5A_42.A W03G1.3 W03G1.3 Member of an uncharacterized protein family W03G1.4 W03G1.4 Member of the polypeptide chain release factor protein family W03G1.5 W03G1.5 Protein with weak similarity to C. elegans F58G11.2 gene product W03G1.6 W03G1.6 Protein containing a protein kinase domain and a C-terminal kinase associated domain 1, has low similarity to microtubule affinity regulating kinase (human MARK1), which is a serine-threonine kinase that phosphorylates protein tau (human MAPT) protein kinase W03G1.7 W03G1.7 Protein with low similarity to acid sphingomyelinase (C. elegans ASM-2) sphingomyelin phosphodiesterase W03G1.8 W03G1.8 Protein of unknown function W03G1.9 W03G1.9 Protein containing an F-box domain, which serve as a link between a target protein and a ubiquitin-conjugating enzyme W03G11.1 W03G11.1 Protein containing two collagen triple helix repeats and one nematode cuticle collagen N-terminal domain, has a region of moderate similarity to a region of the alpha 1 subunit of type II collagen (human COL2A1), which is involved in cartilage development cuticle collagen; col-181 is homologous to the human gene PRO ALPHA 1(I) COLLAGEN (COL1A1; OMIM:120150), which when mutated leads to osteogenesis imperfecta. W03G11.2 W03G11.2 Protein with moderate similarity to C. elegans R08C7.2 (Member of the Cdc50p-like protein family) W03G11.3 W03G11.3 Protein with high similarity to alpha-L-fucosidase (rat Fuca1), which is a glycosylated lysosomal hydrolase that catalyzes the cleavage of fucoglycoconjugates and may play a role in sperm-egg interactions, member of the alpha-L-fucosidase family alpha-L-fucosidase precursor W03G11.4 W03G11.4 Protein of unknown function W03G9.1 W03G9.1 Protein with weak similarity to choline transporter 1 (rat CHOT1), which is a sodium-dependent transporter of choline and creatine neurotransmitter transporter W03G9.2 W03G9.2 Protein with weak similarity to C. elegans Y45G5AM.2 gene product W03G9.3 W03G9.3 Member of an uncharacterized protein family W03G9.4 W03G9.4 Aminopeptidase P aminopeptidase W03G9.5 W03G9.5 Protein containing a protein kinase domain, has low similarity to S.pombe Cki3p, which is a putative casein kinase protein kinase W03G9.6 paf-1;W03G9.6 Protein with moderate similarity to platelet-activating factor acetylhydrolase 2 (serine-dependent phospholipase A2, human PAFAH2), which hydrolyzes short chain or oxidized phospholipids and the acetyl group of platelet-activating factor W03G9.7 W03G9.7 Protein with weak similarity to S. cerevisiae NIP100 (Nuclear import protein) W03H1.2 W03H1.2 Member of the Skp1 family, has a region of high similarity to transcription elongation factor B (SIII) polypeptide 1 (human TCEB1), which is a 15 kD regulatory subunit of the elongin complex that suppresses transient pausing of RNA polymerase II RNA polymerase II elongation factor; elc-2 encodes a protein containing a Skp1 dimerisation domain that has homology to human transcription elongation factor B (SIII), polypeptide I (15kD, elonginsC). W03H9.1 W03H9.1 Member of an uncharacterized protein family W03H9.2 W03H9.2 Protein of unknown function, has moderate similarity to C. elegans Y94H6A_148.L W03H9.3 W03H9.3 Protein of unknown function, has weak similarity to C. elegans Y53F4B.U W03H9.4 W03H9.4 Protein of unknown function, has a region of high similarity to a region of NY-REN-24 antigen (human LOC58509), which is a renal cell carcinoma tumor antigen that is recognized by patients' autologous antibody W04A4.2 W04A4.2 Protein of unknown function W04A4.3 W04A4.3 Protein of unknown function, has weak similarity to C. elegans Y18D10A.C W04A4.4 W04A4.4 Calpain family cysteine protease calpain thiol protease W04A4.5 W04A4.5 Putative ortholog of C. elegans W04A4.6 gene product W04A8.1 W04A8.1 Protein containing three BRCA1 (breast cancer type 1) C terminus (BRCT) domains, which are found in some cell cycle checkpoint proteins BRCA1 C Terminus (BRCT) domain; W04A8.1 encodes a protein weakly similar to human microcephalin (MCPH1; OMIM:607117, mutated in primary microcephaly); while their primary sequence similarity is very subtle (only being detectable with psi-BLAST on NCBI-nr, using C. briggsae CBG13622 as a query sequence), both W04A8.1 and microcephalin has similar ordering of BRCT domains (one N-terminal, two C-terminal); W04A8.1 has no obvious function in mass RNAi screens. W04A8.2 W04A8.2 Protein of unknown function W04A8.3 W04A8.3 Protein of unknown function, has moderate similarity to C. elegans W04A8.5 W04A8.4 W04A8.4 Protein of unknown function, has moderate similarity to C. elegans Y105C5.M W04A8.5 W04A8.5 Protein containing an F-box domain, which serve as a link between a target protein and a ubiquitin-conjugating enzyme, has low similarity to uncharacterized C. elegans W04A8.3 This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins. W04A8.6 W04A8.6 Protein with weak similarity to H. sapiens Hs.154230 (Homo sapiens nuclear domain 10 protein (ndp52) mRNA, complete cds) W04A8.7 taf-1;W04A8.7 Protein containing two bromodomains, has moderate similarity to TATA box binding protein (TBP)-associated factor RNA polymerase II A 250kD (human TAF1), which is a co-activator and TFIID complex component with kinase and histone acetyltransferase activity transcription initiation factor TFIID; The taf-1 gene encodes an ortholog of human TATA-binding protein associated factor TAF1L (TAFII250) that possesses histone acetyl transferase (HAT) activity and is a component of the TFIID general transcription factor that recognizes the transcription start site; TAF-1 is required for proper embryonic and larval development. W04B5.1 W04B5.1 Protein of unknown function W04B5.2 W04B5.2 Protein of unknown function, has weak similarity to C. elegans F49B2.3 W04B5.3 W04B5.3 Protein of unknown function W04B5.4 W04B5.4 Protein of unknown function W04B5.5 piak;W04B5.5 Serine/threonine protein kinase with similarity to phosphoinositide-dependent protein kinases, but not affected by phosphoinositides; may act as a "survival kinase" protein kinase; The W04B5.5 gene encodes a phospholipid-independent AKT/PKB kinase. W04B5.6 W04B5.6 Protein of unknown function, putative paralog of C. elegans E02H9.6 W04C9.1 W04C9.1 Member of the ABC transporter family, which are involved in membrane translocation of a variety of compounds, contains an ABC transporter transmembrane domain, has moderate similarity to transporter associated with antigen processing 2 (rat Tap2) ABC transporter; haf-4 encodes a member of the ABC transporter family. W04C9.2 W04C9.2 Protein of unknown function W04C9.3 W04C9.3 Protein with similarity to cuticlins cuticlin W04C9.4 W04C9.4 Protein of unknown function W04C9.5 W04C9.5 GTP-binding protein of the ras superfamily W04C9.6 W04C9.6 Protein with weak similarity to brain-specific Na+-dependent inorganic phosphate cotransporter (rat Slc17a7), which is a vesicular glutamate transporter that has a presynaptic role in glutamatergic neurotransmission W04D12.1 W04D12.1 Protein of unknown function W04D2.1 W04D2.1 Protein with high similarity to alpha actinin 2 (human ACTN2), which may act in cell communication, sarcomere alignment, and regulation of cardiac potassium channel localization, contains four calponin homology (CH) domains and eight spectrin repeats alpha-actinin; atn-1 encodes an alpha-actinin homolog. W04D2.2 W04D2.2 Protein containing a DUF32 domain of unknown function, has high similarity to uncharacterized C. elegans Y5H2B.7 W04D2.3 opu-11;inx-11;W04D2.3 Member of the integral membrane innexin family, which are involved in the formation of gap junctions, has moderate similarity to C. elegans UNC-7, which is required in motor neurons for coordinated locomotion Ogre family; inx-11 encodes a predicted member of the innexin family; expressed in the pharynx, a few head neurons, the tail hypodermis, posterior intestine and in some vulval and uterine muscles. W04D2.4 W04D2.4 Protein containing a C2H2 type zinc finger domain, which bind nucleic acids Zinc finger, C2H2 type W04D2.5 W04D2.5 Similar to S. cerevisiae Yn1306p, a mitochondrial ribosomal protein of the small subunit mitochondrial ribosomal protein S11 like; This gene encodes a protein predicted by Eisenberg and coworkers, with 68% accuracy, to be mitochondrial. W04D2.6 W04D2.6 Protein containing two PWI domains, which may be involved in mRNA splicing, and an RNA recognition motif (RRM, RBD, or RNP), has low similarity to uncharacterized human S164 RNA recognition motif. (aka RRM, RBD, or RNP domain) W04E12.1 W04E12.1 Protein containing a DUF38 domain of unknown function, has low similarity to a region of C. elegans FOG-2, which is required for the sexual identity of germ cells W04E12.2 W04E12.2 Protein of unknown function, has strong similarity to uncharacterized C. elegans C31G12.1 W04E12.3 W04E12.3 Protein of unknown function W04E12.4 W04E12.4 Protein with strong similarity to C. elegans C14A6.6 W04E12.5 W04E12.5 Protein of unknown function, has moderate similarity to C. elegans C14A6.5 W04E12.6 W04E12.6 Member of the C-type lectin family, has similarity to human lymphocyte antigen LY75, has similarity to D. melanogaster selectin FW (furrowed) Lectin C-type domain short and long forms (2 domains) W04E12.7 W04E12.7 Member of an uncharacterized protein family W04E12.8 W04E12.8 Member of the C-type lectin family, has similarity to human lymphocyte antigen LY75, has similarity to D. melanogaster selectin FW (furrowed) Lectin C-type domain short and long forms (2 domains) W04G3.1 W04G3.1 Protein of unknown function W04G3.2 W04G3.2 Protein of unknown function, has weak similarity to C. elegans W04G3.8 W04G3.3 W04G3.3 Protein with strong similarity to C. elegans W04G3.8 gene product W04G3.4 W04G3.4 Protein containing a VHS domain of unknown function, has low similarity to golgi-associated gamma-adaptin ear containing ARF-binding protein 2 (VHS and EAR domains, human GGA2), which binds clathrin and may link cargo molecules to clathrin-coated vesicles Domain present in VPS-27, Hrs and STAM; apt-9 gene encodes an ortholog of GGA (Golgi-localizing, gamma-adaptin ear homology, ARF-binding protein), which contains a domain paralogous to the gamma-adaptin subunits of adaptor protein complexes; based on structural similarity, APT-9 may beinvolved in the formation of intracellular transport vesicles. W04G3.5 W04G3.5 Protein with high similarity to phosphoribosylpyrophosphate synthetase-associated protein 39 (rat Prpsap1), which is a regulatory subunit of the PRPP synthetase complex and regulates the formation of PRPP, contains a phosphoribosyl transferase domain ribose-phosphate pyrophosphokinase W04G3.6 W04G3.6 Member of the sulfate transporter family, has moderate similarity to a region of solute carrier family 26 member 4 (pendrin, human SLC26A4), which is an anion transporter that may transport bicarbonate and iodide and is associated with Pendred syndrome dra like protein W04G3.7 W04G3.7 Protein of unknown function, has weak similarity to C. elegans Y52B11A.8 W04G3.8 W04G3.8 Protein of unknown function, has moderate similarity to C. elegans W04G3.3 W04G5.1 W04G5.1 Protein containing a paired box (PAX) domain, has low similarity to C. elegans C03E10.2, which is TcA transposase transposase W04G5.10 W04G5.10 Putative ortholog of C. elegans kin-23 gene product W04G5.2 W04G5.2 Protein with high similarity to ras p21-like small GTP-binding protein 11a (human RAB11A), which is a GTP-binding protein and putative GTPase that may play a role in vesicle transport and is associated with dysplasia of Barrett's epithelia W04G5.3 W04G5.3 Protein of unknown function, has weak similarity to C. elegans F59B1.9 W04G5.4 W04G5.4 Member of an uncharacterized protein family W04G5.5 W04G5.5 Protein of unknown function, has moderate similarity to C. elegans Y50D4B_7.A W04G5.6 W04G5.6 Putative tyrosine kinase receptor tyrosine-protein kinase (KIN15/KIN16 subfamily) (4 domains); kin-23 encodes a predicted protein tyrosine kinase; like KIN-30, KIN-23 contains an unusual K to R substitution in kinase subdomain VII; kin-23 mRNA is expressed strongly during the L1/L2 larval stages, weakly in L3 and L4 stages, and at undetectable levels in adults. W04G5.7 W04G5.7 Protein of unknown function, putative paralog of C. elegans W04G5.8 W04G5.8 W04G5.8 Protein of unknown function, putative paralog of C. elegans W04G5.7 W04G5.9 W04G5.9 Protein of unknown function, has weak similarity to C. elegans Y53H1C.A W04H10.1 W04H10.1 Protein of unknown function, has weak similarity to C. elegans Y51H7C_255.D W04H10.2 W04H10.2 Protein of unknown function W04H10.3 W04H10.3 Member of the B-box zinc finger family, contains two Filamin (ABP120) or Dictyostelium gelation factor (ABP280 ) repeat domains and two C3HC4 type (RING) zinc fingers, has low similarity to ring finger protein 22 (tripartite motif 3 protein, rat Rnf22) zinc finger protein W04H10.4 W04H10.4 Member of the C-type lectin family W05B10.1 W05B10.1 Member of the histone H3 protein family Core histones H2A, H2B, H3 and H4 W05B10.2 W05B10.2 Protein containing a CCCH-type zinc finger domain, which bind DNA or RNA W05B10.3 W05B10.3 Protein of unknown function, has weak similarity to C. elegans F59A1.6 W05B10.4 W05B10.4 Protein containing a Ras association (RalGDS or AF6) domain Ras association (RalGDS/AF-6) domain W05B10.5 W05B10.5 Protein with similarity to G protein-coupled receptors of an unnamed subfamily, no homolog found in human or D. melanogaster, may have fewer than 7 transmembrane domains W05B2.1 W05B2.1 Protein with high similarity to C. elegans DPY-16, which is a collagen involved in morphogenesis of the epithelium, contains two collagen triple helix repeats and one nematode cuticle collagen N-terminal domain W05B2.2 W05B2.2 Protein containing six kunitz or bovine pancreatic trypsin inhibitor domains and two EB module domains, has a region of weak similarity to C. elegans MEC-9, which is required for touch sensation Kunitz/Bovine pancreatic trypsin inhibitor domain W05B2.4 W05B2.4 Protein with similarity over the N-terminus to dynein heavy chains W05B2.5 W05B2.5 Protein with high similarity to C. elegans DPY-16, which is a collagen, contains two collagen triple helix repeats, which are found in some extracellular proteins, and a nematode cuticle collagen N-terminal domain W05B2.6 W05B2.6 Protein with high similarity to C. elegans DPY-16, which is a collagen, member contains two collagen triple helix repeats, which are found in some extracellular proteins, and a nematode cuticle collagen N-terminal domain W05B2.7 W05B2.7 Protein with weak similarity to S. cerevisiae DYN1 (Cytoplasmic dynein, heavy chain, mutants have defect in spindle orientation and nuclear migration) W05B5.1 W05B5.1 Protein of unknown function W05B5.2 W05B5.2 Member of the rhodopsin family of G-protein coupled receptors (GPCR), has low similarity to orexin (hypocretin) receptor 2 (rat Hcrtr2), which is a G protein-coupled receptor that binds the orexin (hypocretin, rat Hcrt) neuropeptides 7 transmembrane receptor (rhodopsin family) (2 domains) W05B5.3 nhr-85;W05B5.3 Protein containing nuclear hormone receptor C4-type zinc finger and ligand-binding domains, has low similarity to retinoid X receptor gamma (mouse Rxrg), which serves as transcriptional coactivator and plays a role in synaptic plasticity Ligand-binding domain of nuclear hormone receptors; nhr-85 encodes a nuclear receptor of the NR1 subfamily that is orthologous to the insect E75 nuclear receptors that regulate molting and metamorphosis, and human NR1D1, which is involved in mammalian circadian rhythms; by homology, NHR-85 likely functions as a transcription factor that,based upon RNAi experiments, is required for development of the egg-laying system and formation of SDS-resistant dauer larvae; an nhr-85 reporter fusion is expressed in the hypodermis, the excretory and rectal epithelia, and the vulva; nhr-85 mRNA is expressed in an oscillating manner throughout larval development, in a pattern that is slightly irregular with respect to the timing of larval molts. W05E10.1 W05E10.1 Member of the sugar (and other) transporter family, has moderate similarity to uncharacterized C. elegans ZK550.2 multidrug resistance protein W05E10.2 W05E10.2 Protein of unknown function W05E10.3 ceh-32;W05E10.3 Homeodomain transcription factor required for head morphogenesis; similar to the D. melanogaster SO (sine oculis) and human SIX3 homeodomain transcription factors, which are involved in eye formation homeobox protein (so subfamily); ceh-32 encodes a Six/sine oculis-type homeodomain protein most closely related to the Six3/6 subfamily that contains Drosophila OPTIX and human SIX3 (OMIM:603714, which when mutated leads to holoprosencephaly 2); CEH-32 appears to be essential for development and required for proper head morphogenesis; during embryogenesis, CEH-32 is expressed in hypodermal and neuronal precursors, and at later stages, in the descendants of these cells and in gonadal sheath cells; in some hypodermal cells, ceh-32 is a direct transcriptional target of VAB-3, a PAX-6 ortholog sufficient to induce ceh-32 expression in some cell types and able to bind the ceh-32 promoter in vitro. W05E10.4 W05E10.4 Member of the trehalase family, which are O-glycosyl hydrolases, has moderate similarity to trehalase (human TREH), which catalyzes the hydrolysis of the disaccharide alpha, alpha-trehalose and plays a role in digestion and metabolism of carbohydrates trehalase; tre-2 encodes one of four putative trehalases in C. elegans of unknown function, as RNAi analysis has not produced an obvious phenotype; expressed throughout development. W05E7.1 grd-3;grd-13;W05E7.1 Protein of unknown function, has strong similarity to C. elegans GRD-4 grd-3 encodes a predicted secreted protein that is a member of the C. elegans groundhog gene family; by homology, GRD-3 is predicted to be involved in cell communication, and likely plays a role in antibacterial defense, as its expression is robustly induced upon infection of C. elegans with a gram-negative bacterium; loss of grd-3 activity via RNA-mediated interference (RNAi), however, does not result in any obvious abnormalities; a grd-3 reporter gene is expressed in adults in anterior and posterior hypodermal seam cells, in a pattern that overlaps that of grd-5. W05E7.2 W05E7.2 Protein with moderate similarity to C. elegans Y116F11C.f gene product 7TM chemoreceptor, srz family W05F2.2 W05F2.2 Protein of unknown function, has strong similarity to uncharacterized C. elegans W03G9.3 W05F2.3 W05F2.3 Protein of unknown function W05F2.4 W05F2.4 Protein of unknown function W05F2.5 W05F2.5 Protein containing an F-box domain, which serve as a link between a target protein and a ubiquitin-conjugating enzyme, has weak similarity to uncharacterized C. elegans F59A1.9 This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins; this gene's encoded protein also contains an FTH/DUF38 motif, which may also mediate protein-protein interaction. W05F2.6 W05F2.6 Protein of unknown function W05F2.7 W05F2.7 Protein with moderate similarity to C. elegans hpl-2 gene product W05G11.2 W05G11.2 Putative ortholog of C. elegans ZK678.3 gene product W05G11.3 W05G11.3 Protein containing two collagen triple helix repeats, which are found in some extracellular proteins, and a nematode cuticle collagen N-terminal domain, has high similarity to a region of C. elegans BLI-1 cuticular collagen W05G11.4 W05G11.4 Member of the calpain family of cysteine proteases, has a region of low similarity to a region of mouse Capn9, which is a calcium-dependent non-lysosomal protease that suppresses neoplastic transformation protease W05G11.5 W05G11.5 Protein containing a BTB (BR-C, ttk and babor) or POZ (Pox virus and zinc finger) domain, which are found in some DNA and actin binding proteins and may mediate protein-protein interactions W05G11.6 W05G11.6 Protein with high similarity to cytosolic phosphoenolpyruvate carboxykinase (mouse Pck1), which catalyzes the formation of phosphoenolpyruvate by decarboxylation of oxaloacetate, member of the phosphoenolpyruvate carboxykinase (GTP) family phosphoenolpyruvate carboxykinase W05H12.1 W05H12.1 Protein with strong similarity to C. elegans Y40B1B.4 gene product W05H12.2 W05H12.2 Protein containing a 3'-5' exonuclease domain, which catalyze the hydrolysis of mismatched or unpaired nucleotides W05H5.1 W05H5.1 Protein with strong similarity to C. elegans Y57A10C.10 gene product W05H5.2 W05H5.2 Protein of unknown function, has weak similarity to C. elegans AH10.4 W05H5.3 W05H5.3 Phosphate permease phosphate permease W05H5.4 W05H5.4 Member of the 7-transmembrane chemoreceptor family of G-protein coupled receptors (GPCR), has high similarity to uncharacterized C. elegans T12A7.7 W05H5.5 W05H5.5 Member of the C. elegans Sre G protein-coupled chemoreceptor family, which are putative chemosensory receptors, has high similarity to uncharacterized C. elegans W05H5.6 7TM receptor, sre family W05H5.6 W05H5.6 Member of the C. elegans Sre G protein-coupled chemoreceptor family, which are putative chemosensory receptors, has high similarity to uncharacterized C. elegans F57G9.4 7TM receptor, sre family W05H5.7 W05H5.7 Member of the C. elegans Sre G protein-coupled chemoreceptor family, which are putative chemosensory receptors, has high similarity to uncharacterized C. elegans F57G9.4 7TM receptor, sre family W05H7.1 W05H7.1 Protein of unknown function W05H7.2 W05H7.2 Protein of unknown function, has moderate similarity to C. elegans C32H11.7 W05H7.3 W05H7.3 Protein with high similarity to spondyloepiphyseal dysplasia late (sedlin, human SEDL), which may play a role in vesicular transport between the endoplasmic reticulum and the Golgi and is associated with spondyloepiphyseal dysplasia when mutated W05H7.4 W05H7.4 Protein containing a CCCH-type zinc finger domain, which bind DNA or RNA W05H7.5 W05H7.5 Protein of unknown function W05H9.1 W05H9.1 Protein with weak similarity to C. elegans unc-54 (Sarcomeric Myosin Heavy Chain, major component of thick filaments in body-wall muscle) W05H9.2 W05H9.2 Protein of unknown function W05H9.3 W05H9.3 Protein of unknown function W06A11.1 W06A11.1 Protein of unknown function W06A11.2 W06A11.2 Member of the zyg-11 like protein family W06A11.3 W06A11.3 Protein of unknown function, has weak similarity to C. elegans B0462.3 W06A11.4 W06A11.4 Protein of unknown function, has moderate similarity to C. elegans ZC204.14 W06A7.2 W06A7.2 Protein of unknown function W06A7.3 W06A7.3 Member of the reticulon family, which are proteins that associate with the endoplasmic reticulum, has a region of low similarity to a region of reticulon 1 (human DLL1), which is involved in somite development and neuronal differentiation histone H4 protein like W06A7.4 W06A7.4 Protein of unknown function, has low similarity to uncharacterized C. elegans W02D3.4 W06A7.5 W06A7.5 Protein of unknown function, has weak similarity to C. elegans ZC412.7 W06B11.1 W06B11.1 Protein of unknown function, has low similarity to uncharacterized C. elegans F57H12.7 W06B11.2 W06B11.2 Putative ortholog of Drosophila pumilio protein pumilo repeats; The puf-9 gene encodes a predicted RNA binding protein orthologous to Drosophila PUMILIO and human PUMILIO 2 (OMIM:607205); PUF-9 is required for normal locomotion and fluid balance, and is expressed primarily in somatic tissues; PUF-9 contains a glutamine/asparagine-rich domain. W06B11.3 W06B11.3 Protein of unknown function W06B11.4 W06B11.4 Predicted pseudogene, has strong similarity to C. elegans grd-1 gene product warthog W06B3.1 W06B3.1 Member of the nicotinamide mononucleotide (NMN) adenylyltransferase protein family W06B3.2 W06B3.2 Protein containing a protein kinase domain, has low similarity to mitogen activated protein kinase 3 (rat Mapk3), which is a serine-threonine kinase that transduces signals from cell surface receptors and is involved in cell proliferation serine/threonine kinase (CDC2/CDC28 subfamily); sma-5 encodes a serine/threonine kinase homologous to the mammalian MAP kinase MAPK7/ERK5 (OMIM:602521, required for development of extraembryonic vasculature and embryonic cardiovasculature); SMA-5 is required for normal body size morphogenesis, growth rates, and intestinal granule distribution, and for regulating the size of the intestine, body wall muscle, and hypodermis, as well as the number of intestinal nuclei; SMA-5 is expressed in the intestine and in hypodermal seam cells. W06B4.1 W06B4.1 Protein of unknown function, has moderate similarity to C. elegans W06B4.2 W06B4.2 W06B4.2 Protein of unknown function, has a region of low similarity to N-acetylglucosamine kinase (mouse Nagk), which is an enzyme that phosphorylates N-acetylglucosamine and N-acetylmannosamine and promotes their entry into metabolic pathways W06B4.3 W06B4.3 Protein with weak similarity to S. cerevisiae Pep3p, which is a vacuolar peripheral membrane protein that is involved in vacuolar protein sorting and is required for vacuole biogenesis W06D11.1 W06D11.1 Protein of unknown function W06D11.2 W06D11.2 Protein with weak similarity to C. elegans C49D10.11 gene product W06D11.3 W06D11.3 Protein of unknown function W06D11.4 W06D11.4 Putative paralog of C. elegans F54F7.7, has similarity over the C-terminal half to S. cerevisiae cell cycle arrest protein Pch1p W06D11.5 W06D11.5 Protein of unknown function, has moderate similarity to C. elegans F02H6.4 W06D12.1 W06D12.1 Protein with moderate similarity to C. elegans cut-1 (Cuticulin component) W06D12.2 W06D12.2 Member of the ion transport family, which include calcium, sodium, and potassium channels, has weak similarity to tandem pore domain potassium channel THIK-1 (rat Kcnk13) W06D12.3 fat-5;W06D12.3 Likely a palmitoyl-CoA delta-9 fatty acid desaturase, specific for medium chain (14:0 - 17:0) fatty acids Fatty acid desaturase; fat-5 encodes a delta-9 fatty acid desaturase that is predicted to be mitochondrial; when expressed heterologously in S. cerevisiae, FAT-5 rescues the fatty acid auxotrophy of the yeast delta-9 desaturase mutant ole1. W06D12.4 W06D12.4 Member of the 7-transmembrane chemoreceptor family of G-protein coupled receptors (GPCR), has low similarity to C. elegans ODR-10, which is a G protein-coupled receptor involved in odorant response W06D12.5 W06D12.5 Member of the potassium channel TWK-13 protein family W06D12.6 W06D12.6 Protein of unknown function, has weak similarity to C. elegans F28B1.3 W06D12.7 W06D12.7 Protein of unknown function, putative paralog of C. elegans Y26G10.2 W06D4.1 hgo-1;HGO;W06D4.1 Protein with high similarity to homogentisate 1,2-dioxygenase (human HGD), which is an iron-dependent dioxygenase that is involved the catabolism of tyrosine and phenylalanine and is associated with alkaptonuria HOMOGENTISATE 1,2-DIOXYGENASE (EC 1.13.11.5) (HOMOGENTISICASE) (HOMOGENTISATE OXYGENASE) (HOMOGENTISIC ACID OXIDASE); hgo-1 is orthologous to the human gene SIMILAR TO HOMOGENTISATE 1,2-DIOXYGENASE (HOMOGENTISATE OXIDASE) (HGD; OMIM:203500), which when mutated leads to disease. W06D4.2 W06D4.2 Protein of unknown function, putative paralog of C. elegans T06D10.A W06D4.3 W06D4.3 Protein of unknown function, putative paralog of C. elegans T06D10.A W06D4.4 W06D4.4 Protein of unknown function, has low similarity to uncharacterized human FLJ10640 W06D4.5 W06D4.5 Protein with high similarity to sorting nexin 3 (human SNX3), which is a protein involved in intracellular protein trafficking, contains a phox protein (PX) domain, which bind phosphoinositides PhoX homologous domain, present in p47phox and p40phox. W06D4.6 rad-54;W06D4.6 Protein with high similarity to mouse Rad54l, which is a DNA-dependent ATPase and DNA helicase that functions in DNA recombination and repair, contains a helicase conserved C-terminal domain and an SNF2 related N-terminal domain SNF2 and others N-terminal domain; rad-54 is orthologous to the human gene RAD54 (RAD54L; OMIM:603615), which when mutated leads to disease. W06E11.1 W06E11.1 Protein of unknown function W06E11.2 W06E11.2 Protein of unknown function W06E11.4 W06E11.4 Member of the uncharacterized protein family UPF0023, has high similarity to uncharacterized human LOC51119 W06E11.5 W06E11.5 Protein of unknown function, has high similarity to uncharacterized cysteine-rich hydrophobic domain 2 (human CHIC2), which is predicted to function in calcium-regulated exocytosis W06E11.5 is orthologous to human CYSTEINE-RICH HYDROPHOBIC 2 (CHIC2; OMIM:604332); chromosomal rearrangements fusing CHIC2 to ETV6 are found in both myeloid and lymphoid leukemias. W06E11.7 W06E11.7 Protein of unknown function W06F12.1 W06F12.1 Serine/threonine protein kinase of the MAP kinase subfamily serine/threonine kinase (CDC2/CDC28 subfamily); lit-1 encodes a serine threonine protein kinase homolog related to the Drosophila protein Nemo that is required for embryonic viability, plays a central role in controlling the asymmetry of cell divisions during embryogenesis, and affects EMS, MS, and C lineages; acts downstream of mom-2 with respect to polarity defects and mediates larval cell fate decisions that involve POP-1, and is expressed in most embryonic and larval cells. W06F12.2 W06F12.2 Protein of unknown function, has weak similarity to C. elegans ZK1010.8 W06F12.3 lit-1;W06F12.3 Serine/threonine protein kinase of the MAP kinase subfamily; functions in establishing anteroposterior polarity of dividing embryonic cells serine/threonine kinase W06G6.1 W06G6.1 Member of the uncharacterized protein family UPF0063, has high similarity to uncharacterized C. elegans F52F10.4 W06G6.10 W06G6.10 Protein of unknown function W06G6.11 W06G6.11 Protein of unknown function W06G6.12 W06G6.12 Putative ortholog of C. elegans Y70C5B.1 gene product W06G6.13 W06G6.13 Putative paralog of C. elegans W06G6.8 7TM chemoreceptor, srw family W06G6.2 W06G6.2 Protein of unknown function W06G6.3 W06G6.3 G protein-coupled receptor, member of a subfamily with SRD proteins which are expressed in chemosensory neurons, no homolog found in human or D. melanogaster 7TM chemoreceptor (srd-family) W06G6.6 W06G6.6 G protein-coupled receptor of unknown function, no homolog found in human or D. melanogaster 7TM chemoreceptor, srw family W06G6.7 W06G6.7 Protein of unknown function, putative paralog of C. elegans W02B8.3 W06G6.8 W06G6.8 Protein of unknown function, has high similarity to uncharacterized C. elegans W06G6.13 7TM chemoreceptor, srw family W06G6.9 W06G6.9 Protein of unknown function W06H12.1 W06H12.1 Protein containing three C2H2 type zinc finger domains, which bind nucleic acids W06H3.1 W06H3.1 Protein of unknown function, has low similarity to uncharacterized C. elegans T14G11.3 [031110 dl] Modified prediction based on EST data, correct splice donor from exon 2 W06H3.2 W06H3.2 Member of the tRNA pseudouridine synthase family, has moderate similarity to pseudouridine synthase 1 (mouse Pus1), which is an RNA binding protein that converts uridine to pseudouridine in tRNA substrates and is involved in tRNA modification pus-1 encodes a putative tRNA pseudouridine synthase that is predicted, by phylogenetic profiling, to be mitochondrial. W06H3.3 W06H3.3 Protein with high similarity to CTP synthase type 2 (human CTPS2), which is an enzyme of the pyrimidine biosynthetic pathway, member of the glutamine amidotransferase class I (trpG-type) family CTP SYNTHASE (EC 6.3.4.2) (UTP--AMMONIA LIGASE) (CTP SYNTHETASE) W06H8.1 rme-1;W06H8.1 Peripheral endosomal protein in the intestine; required for normal basolateral-specific endocytic transport in the intestine The rme-1 gene encodes a C. elegans protein required for endocytosis. W06H8.2 W06H8.2 Putative paralog of C. elegans F17A9.4 (Protein with similarity to NADH oxidases) W06H8.3 W06H8.3 Putative paralog of C. elegans W06H8.C W06H8.4 W06H8.4 Protein of unknown function, putative paralog of C. elegans W06H8.B W06H8.5 W06H8.5 Protein of unknown function W06H8.6 W06H8.6 Protein of unknown function, putative paralog of C. elegans W06H8.A W06H8.7 W06H8.7 Putative ortholog of C. elegans C02E7.9 gene product 7TM chemoreceptor, str family W07A12.4 W07A12.4 Protein containing a BTB (BR-C, ttk and babor) or POZ (Pox virus and zinc finger) domain, which are found in some DNA and actin binding proteins and may mediate protein-protein interactions serine/threonine kinase W07A12.5 W07A12.5 Protein containing two collagen triple helix repeats, which are found in some extracellular proteins, has low similarity to C. elegans ROL-8, which is a collagen collagen W07A12.6 W07A12.6 G protein-coupled receptor, member of unnamed subfamily with distant homology to SRG subfamily, no homolog found in human or D. melanogaster W07A12.7 W07A12.7 Member of the uncharacterized protein family UPF0063, has high similarity to uncharacterized C. elegans W07A12.6 W07A8.1 W07A8.1 Protein of unknown function, has high similarity to uncharacterized C. elegans F56D5.10 W07A8.2 W07A8.2 Member of the palatin family, which are storage proteins, contains seven ankyrin (Ank) repeats, has low similarity to group VI phospholipase A2 (human PLA2G6), which is a cytosolic calcium-independent phospholipase that stimulates arachidonate release Ank repeat (4 domains) W07A8.3 auxilin;W07A8.3 J-domain protein essential for clathrin-mediated endocytosis; similar over C-terminal half to human KIAA0473 protein isolated from a brain cDNA library The dnj-25 (Ce-auxilin) gene is required in vivo for clathrin-mediated endocytosis and for normal development. W07A8.4 W07A8.4 Protein of unknown function, has high similarity to uncharacterized C. elegans F56D5.10 W07A8.5 W07A8.5 Protein of unknown function, has high similarity to uncharacterized C. elegans C31A11.6 W07B3.1 W07B3.1 Protein with strong similarity to C. elegans Y50D7A.8 gene product W07B3.2 W07B3.2 Member of an uncharacterized protein family gei-4 encodes a protein with a coiled-coil domain (predicted to mediate protein-protein interactions), an internal repeat of 69 residues (covering residues 134-202, 203-265, and 266-328 of W07B3.2a), and a glutamine/asparagine-rich domain; GEI-4 is paralogous to Y50D7A.8 and Y59C2A.3, physically interacts with GEX-2, and is required for embryonic viability, fertility, and vulval morphogenesis; GEI-4 is claimed to have weak homology to trichohyalin, a mammalian intermediate filament interacting protein; the similarity of the mutant phenotypes of gei-4, gex-2 and gex-3 and their interaction sugggest that the GEX-2/GEX-3/GEI-4 protein complex is essential for the regulation of intermediate filaments during rearrangement of the cytoskeleton that occurs in embryogenesis; GFI-2, an ankyrin-repeat protein associates with GEI-4 and exhibits a similar mutant phenotype, suggesting that gfi-2 is also involved in intermediate filament dynamics. W07B8.1 W07B8.1 Member of the cysteine protease protein family thiol protease W07B8.3 W07B8.3 Putative ortholog of C. elegans W07B8.2 gene product W07B8.4 W07B8.4 Member of the cysteine protease protein family thiol protease W07B8.5 cpr-5;W07B8.5 Member of the cysteine protease protein family thiol protease; cpr-5 encodes a cysteine protease. W07E11.1 W07E11.1 Protein with high similarity to glutamate synthase (NADPH, GOGAT, S. cerevisiae Glt1), member of the pyridine nucleotide-disulphide oxidoreductase family, contains a conserved region in glutamate synthase domain and a DUF14 domain of unknown function glutamate synthase W07E11.2 flp-3;W07E11.2 Putative FMRF-amide neurotransmitters FMRFamide neuropeptide repeats; flp-3 encodes nine copies of a GTMRFamide-containing peptide that is predicted to function as a neuropeptide that inhibits pharyngeal action potential in a manner similar to octopamine without having a significant effect on basal resting membrane potential; expressed in three pairs of neurons IL1D, OL1, URB. W07E11.3 flp-2;W07E11.3 Putative FMRF-amide neurotransmitters flp-2 encodes a predicted FMRFamide-like peptide neurotransmitter; expressed in the pharyngeal neuron I5. W07E6.1 W07E6.1 Putative ortholog of human proliferating-cell nucleolar protein P120, which is associated with cancer nucleolar protein W07E6.2 W07E6.2 Member of the WD repeat protein family W07E6.3 W07E6.3 Protein of unknown function, has moderate similarity to C. elegans H21P03.3 W07E6.4 prp-21;W07E6.4;Ceprp21 Putative U2 snRNP-associated splicing factor, putative ortholog of human SAP114/SF3a120 and yeast Prp21p, member of the SWAP protein family splicing factor W07E6.5 W07E6.5 Protein of unknown function, has weak similarity to C. elegans F21D9.2 W07E6.6 W07E6.6 Putative paralog of C. elegans ZC247.4 (Member of the Tc3 Transposase protein family) transposase W07G1.1 W07G1.A;W07G1.1 Protein with moderate similarity to C. elegans W07G1.E gene product W07G1.2 W07G1.B;W07G1.2 Member of the C. elegans Sre G protein-coupled chemoreceptor family, which are putative chemosensory receptors, has moderate similarity to uncharacterized C. elegans Y39G8B.3 7TM receptor, sre family W07G1.3 W07G1.C;W07G1.3 Protein with weak similarity to C. elegans F17C11.1 gene product W07G1.4 W07G1.D;W07G1.4 Protein of unknown function W07G1.5 W07G1.5 Putative paralog of C. elegans W07G1.E W07G1.6 W07G1.6 Protein of unknown function, putative paralog of C. elegans W07G1.F 7TM receptor, sre family W07G1.7 W07G1.7 Protein of unknown function, has strong similarity to C. elegans W07G1.F W07G4.1 W07G4.1 Protein of unknown function W07G4.2 W07G4.2 Member of the glycosyl transferase family 11, which hydrolyze the glycosidic bond between two or more carbohydrates, has high similarity to uncharacterized C. elegans K06H6.6 W07G4.3 W07G4.3 Protein containing a protein kinase domain, has low similarity to uncharacterized C. albicans Orf6.5474p serine/threonine kinase W07G4.4 W07G4.4 Protein of unknown function, has weak similarity to C. elegans ZK353.6; may be anchored to the membrane of a secretory vesicle or the Golgi apparatus cytosolic aminopeptidase; This gene encodes a protein predicted by Eisenberg and coworkers, with 68% accuracy, to be mitochondrial. W07G4.5 W07G4.5 Protein of unknown function W07G4.6 W07G4.6 Protein of unknown function, has moderate similarity to C. elegans C13D9.1 W07G9.1 W07G9.1 Protein of unknown function W08A12.1 W08A12.1 Protein of unknown function W08A12.2 W08A12.2 Protein of unknown function W08A12.3 W08A12.3 Protein of unknown function W08A12.4 W08A12.4 Putative coiled-coil protein W08D2.1 egl-20;W08D2.1 Member of the WNT protein family WNT protein; egl-20 encodes a member of the WNT family of developmental signaling proteins that affects migration of QL and QR and their descendents; expressed in muscle and epidermal cells at the posterior of the worm. W08D2.3 W08D2.3 Protein of unknown function W08D2.4 fat-3;W08D2.4 Protein with high similarity to C. elegans FAT-4, which is a delta5-fatty acid desaturase The fat-3 gene encodes a delta-6 fatty acid desaturase ('linoleoyl-CoA desaturase') containing an N-terminal cytochrome b5 domain; FAT-3 expressed in yeast uses linoleic and alpha-linolenic acid as substrates; FAT-3 is absolutely required in vivo for synthesis of delta-6 fatty acids, and also required for fully normal synthesis of C20 fatty acids; FAT-3 is required for a normally fast growth rate and movement speed, and for normal defecation rhythms and fertility. W08D2.5 W08D2.5 Member of the E1-E2 (P-type) ATPase and haloacid dehalogenase or epoxide hydrolase families, has weak similarity to S. cerevisiae Spf1p, which is a putative Ca2+-transporting ATPase Transport ATPase like W08D2.6 W08D2.6 Protein containing two collagen triple helix repeats, which are found in some extracellular proteins and a nematode cuticle collagen N-terminal domain, has moderate similarity to C. elegans SQT-1, which is a collagen collagen; col-123 is homologous to the human gene A TYPE IV COLLAGEN (COL6A1; OMIM:303631), which when mutated is sometimes associated with diffuse leiomyomatosis. W08D2.7 W08D2.7 Member of the DEAD or DEAH box ATP-dependent RNA helicase family and contains a helicase conserved C-terminal domain, has moderate similarity to S. cerevisiae Mtr4p, which is required for mRNA export from nucleus Human myeloid cell line protein 2 like W08D2.8 kin-21;Cehd-3;W08D2.8 Putative tyrosine protein kinase, has similarity to human and D. melanogaster fps/fes-related protein kinases tyrosine-protein kinase (FES/FPS subfamily) W08E12.2 W08E12_12.J;W08E12.J;W08E12.2 Protein of unknown function, has weak similarity to C. elegans W08E12_12.G W08E12.3 W08E12_12.I;W08E12.I;W08E12.3 Protein of unknown function, has moderate similarity to C. elegans W08E12_12.G W08E12.4 W08E12.4 Protein of unknown function, putative paralog of C. elegans W08E12_12.H W08E12.5 W08E12.5 Protein of unknown function, putative paralog of C. elegans W08E12_12.H W08E12.6 W08E12_12.F;W08E12.F;W08E12.6 Protein of unknown function W08E12.7 W08E12_12.E;W08E12.E;W08E12.7 Putative ortholog of human cell cycle protein PA2G4 (Hs.5181, similar to mouse cell cycle protein p38-2G4) peptidase W08E12.8 W08E12.8 Protein of unknown function, has weak similarity to C. elegans W08E12_12.D W08E12.9 W08E12.9 Protein of unknown function W08E3.1 W08E3.1 Member of the Sm family, has high similarity to a region of snRNP polypeptide B (human SNRPB), which is an autoantigen in systemic lupus erythematosus and a component of snRNP complexes that are required units of the spliceosome that bind RNA small nuclear ribonucleoprotein (SNRNP) W08E3.2 W08E3.2 Protein of unknown function, has moderate similarity to a region of H. sapiens Hs.83422/MLN51 gene product W08E3.3 W08E3.3 Member of the GTP-binding protein family GTP-binding protein like W08E3.4 W08E3.4 Protein of unknown function W08F4.1 W08F4.1 Protein of unknown function, has strong similarity to C. elegans Y94H6A_142.G W08F4.10 W08F4.10 Protein of unknown function, has strong similarity to C. elegans W10D9.2 W08F4.11 W08F4.11 Protein of unknown function, has weak similarity to C. elegans Y94H6A_142.I W08F4.12 W08F4.12 Protein of unknown function W08F4.2 W08F4.2 Protein containing an F-box domain, which serve as a link between a target protein and a ubiquitin-conjugating enzyme, has low similarity to uncharacterized C. elegans M151.6 This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins; its encoded protein also contains a Pfam-B45 motif of presently unknown function. W08F4.3 W08F4.3 Protein of unknown function, has weak similarity to human sigma receptor SR-BP1 W08F4.5 W08F4.5 Protein of unknown function, has moderate similarity to C. elegans F54F7.5 W08F4.6 W08F4.6 Protein of unknown function W08F4.7 W08F4.7 Protein of unknown function W08F4.8 W08F4.8 Protein with moderate similarity to cell division cycle 37 homolog (human CDC37), which is a cell cycle regulator that interacts with and is targeted by Hsp90 to human CDK4 to promote human CDK4 stability and plays a role in heme biosynthesis W08F4.9 W08F4.9 Protein of unknown function, has low similarity to uncharacterized C. elegans F58E1.9 W08G11.1 W08G11.1 Member of an uncharacterized protein family W08G11.3 W08G11.3 Protein contains a putative coiled-coil domain, has weak similarity to C. elegans unc-15 (Paramyosin, major component of muscle filaments, structural equivalent of the rod region of myosin heavy chains) W08G11.4 W08G11.4 Protein with high similarity to protein phosphatase 2 regulatory subunit B alpha (human PPP2R5A), which regulates the substrate specificity of cytoplasmic protein phosphatase 2A, member of the protein phosphatase 2A regulatory B subunit (B56) family RTS1 PROTEIN (SCS1 PROTEIN) W09B12.1 ace-1;W09B12.1 Type T acetylcholinesterase ace-1 encodes a class A acetylcholinesterase that functions redundantly with ACE-2 with respect to total class A acetylcholinesterase activity, and that genetically interacts with ace-2 and ace-3; ace-1 is expressed in the body wall muscle, sphincter muscle, head neurons, a few pharyngeal muscle cells, and the diagonal and spicule muscles of the male. W09B6.1 W09B6.1 Protein containing a biotin or lipoyl attachment, a carbamoyl-phosphate synthase L chain N-terminal and ATP binding, a biotin carboxylase C-terminal and a carboxyl transferase domain, has low similarity to acetyl-coenzyme A carboxylase alpha (rat Acac) acetyl-CoA carboxylase W09B6.2 taf-3.1;W09B6.2 Protein containing a TATA box binding protein associated factor (TAF) domain, has low similarity to a region of TAF6 RNA polymerase II TATA box binding protein-associated 80 kD factor (human TAF6), which is a general transcription factor W09B6.3 W09B6.3 Protein of unknown function W09B6.4 W09B6.4 Protein of unknown function W09B6.5 W09B6.5 Protein of unknown function W09B7.1 W09B7.1 Putative ortholog of C. elegans W09B7.C gene product W09B7.2 W09B7.2 Putative ortholog of C. elegans W09B7.B gene product W09B7.3 W09B7.3 Putative ortholog of C. elegans W09B7.A gene product W09C2.1 elt-1;W09C2.1 GATA transcription factor that may act to specify the major hypodermal cell fate elongation factor ELT; The elt-1 gene encodes a GATA transcription factor expressed in the embryonic hypodermis, and is essential for the production of most hypodermal cells. W09C2.3 mca-1;W09C2.3 Protein with high similarity to human ATP2B4, member of the E1-E2 (P-type) ATPase and haloacid dehalogenase or epoxide hydrolase families, contains one cation transporter or ATPase N-terminus domain and one cation transporting ATPase C-terminal domain calcium ATPase, isoform a W09C3.1 W09C3.1 Protein containing a protein kinase domain, has low similarity to casein kinase 1 delta (rat Csnk1d), which is a serine/threonine protein kinase possibly involved in DNA repair serine/threonine protein kinase W09C3.2 W09C3.2 Protein with weak similarity to H. sapiens Hs.18141 (Human ladinin (LAD) mRNA, complete cds) W09C3.3 W09C3.3 Member of the domain of unknown function DUF13 family, has high similarity to uncharacterized C. elegans F28A10.1 W09C3.4 W09C3.4 Protein with low similarity to RNA polymerase III subunit 39 (human POLR3F), which is a subunit of RNA polymerase III and part of a subcomplex important for the initiation of transcription W09C3.6 W09C3.6 Protein with high similarity to S. cerevisiae Glc7p, which is a protein serine threonine phosphatase PP1 required for glucose repression, membrane bilayer mixing, and vesicular trafficking, member of the serine or threonine protein phosphatase family serine/threonine protein phosphatase PP1 W09C3.7 W09C3.7 Protein of unknown function W09C3.8 W09C3.8 Putative ortholog of C. elegans F02E9.8 gene product W09C5.1 W09C5.1 Putative ortholog of S. cerevisiae Yer126p, a protein of unknown function W09C5.2 unc-59;W09C5.2 Septin, involved in cytokinesis Cell division protein; unc-59, by alternative splicing, encodes two septin isoforms required (like the septins UNC-61A/B) for normal axonal migration, distal tip cell migration, and postembryonic cytokinesis (at the cellular level) and for normal locomotion and formation of the postembryonic vulva, somatic gonad, and male tail (at the organismal level); both UNC-59 and UNC-61A/B are dispensable for embryonic cytokinesis and development, but are thought to be required for all postembryonic cytokinesis; UNC-59 and UNC-61A/B depend on each other for localization to the cytokinetic furrow. W09C5.4 W09C5.4 Protein of unknown function ins-33 encodes an insulin-like peptide of the insulin superfamily of proteins (OMIM:176730, 147440); INS-33 is one of 38 insulin-like peptides in C. elegans; loss of INS-33 function can result in embryonic lethality, slow growth, and lack of coordination; additionally, INS-33 appears to be a direct downstream target of LIN-14, a nuclear protein and key regulator of the temporal sequence of postembryonic developmental events. W09C5.5 W09C5.5 Serine/threonine protein kinase, has strong similarity to human novel protein kinase C family members EPK2 and mu Phorbol esters/diacylglycerol binding domain (C1 domain) ; Eukaryotic protein kinase domain W09C5.6 W09C5.6 Member of the ribosomal protein L31 family Ribosomal protein L31e; rpl-31 encodes a large ribosomal subunit L31 protein. W09C5.7 W09C5.7 Protein containing a SacI homology domain, has a region of moderate similarity to a region of supressor of actin 1 (rat Sacm1l), which is an integral membrane lipid phosphatase that acts on PI 3 phosphate, PI 4 phosphate, and PI 3,5 bisphosphate W09C5.8 W09C5.8 Member of the cytochrome c oxidase subunit IV family, which are part of the terminal oxidase in the mitochondrial electron transport chain, has low similarity to uncharacterized cytochrome c oxidase subunit IV (rat Cox4a) W09C5.9 W09C5.9 Protein of unknown function W09D10.1 W09D10.1 Protein containing a putative arf GTPase activation (GAP) domain, which have C-4 class zinc fingers, has a region of high similarity to a region of centaurin-alpha (rat Gcs1l), which is a PtdIns(3,4,5)P3-binding protein RNA recognition motif. (aka RRM, RBD, or RNP domain) W09D10.2 W09D10.2 Member of the P-type ATPase, Drs2p subfamily protein family ATPase W09D10.3 W09D10.3 Putative mitochondrial L12 ribosomal protein ribosomal protein L7/L12 mitochondrial; This gene encodes a protein predicted by Eisenberg and coworkers, with 52% accuracy, to be mitochondrial. W09D10.4 W09D10.4 Member of the protein phosphatase 2C family, which are Mg2+ dependent protein serine and threonine phosphatases, has moderate similarity to S. pombe Azr1p, which is involved in resistance to 5-azacytidine Protein phosphatase 2C (2 domains) W09D10.5 W09D10.5 Protein of unknown function, has weak similarity to C. elegans C38H2.2 W09D12.1 W09D12.1 Member of the matrixin family, which are extracellular matrix metalloproteases that may be involved in tissue remodeling, has a region of weak similarity to C. elegans C31B8.8, which is a metalloprotease zinc metalloprotease W09D12.2 W09D12.2 Putative ortholog of C. elegans W09D12.1 gene product G-protein coupled receptor, srg family W09D6.1 W09D6.1 Member of the AMP-binding enzyme family, contains three bacterial pyrrolo-quinoline quinone (PQQ) repeat domains AMP-binding enzyme, PQQ enzyme repeat (3 domains) W09D6.2 W09D6.2 Member of the 7-transmembrane chemoreceptor family of G-protein coupled receptors (GPCR), has low similarity to uncharacterized C. elegans Y9C9A.9 W09D6.3 W09D6.3 Member of the 7-transmembrane chemoreceptor family of G-protein coupled receptors (GPCR), has low similarity to C. elegans ODR-10, which is a G protein-coupled receptor involved in odorant response W09D6.4 W09D6.4 Protein of unknown function, has very strong similarity to uncharacterized C. elegans Y47D3A.13 W09D6.5 W09D6.5 Protein of unknown function W09D6.6 W09D6.6 Member of the ABC transporter family, which are involved in membrane translocation of a variety of compounds, has a region of moderate similarity to vacuolar ATP-binding cassette (ABC) transport protein involved in heavy metal tolerance (S. pombe Hmt1p) multidrug resistance protein (p-glycoprotein); haf-5 encodes a predicted transmembrane half-molecule ATP-binding cassette (ABC) transporter orthologous to Schizosaccharomyces pombe heavy metal tolerance factor 1 (SpHMT1), an ATP-dependent phytochelatin transporter; HAF-5 is required for cadmium detoxification and by homology, is predicted to promote sequestration of heavy metal-containing phytochelatins into intracellular vacuoles to protect cells from potential damage. W09G10.1 W09G10.1 Protein containing two collagen triple helix repeats, which are found in some extracellular proteins, has a region of high similarity to a region of collagen type IV, alpha 2 subunit (human COL4A2), which may be involved in endothelial cell apoptosis collagen W09G10.3 W09G10.3 Protein containing two EF hand domains, which are found in signaling, buffering, or transport proteins W09G10.4 W09G10.4 Protein containing two clathrin-associated adaptin N-terminal domains, which are components of coated vesicles, has moderate similarity to delta-adaptin (human AP3D1), which is a component of the AP-3 complex involved in intracellular vesicle transport The apt-5 gene encodes an adaptin: specifically, it encodes an ortholog of the delta subunit of adaptor protein complex 3 (AP-3). W09G10.5 W09G10.5 Member of the C-type lectin family, has weak similarity to human C-type mannose receptor MRC1, human neurocan and versican chondroitin sulfate proteoglycans, and human selectin E entothelial adhesion molecule W09G10.6 W09G10.6 Protein containing a C-type lectin domain, which mediate calcium-dependent carbohydrate recognition W09G12.1 W09G12.1 Protein with strong similarity to C. elegans F15B9.3 gene product W09G12.3 W09G12.3 Protein with strong similarity to C. elegans W09G12.4 gene product W09G12.4 W09G12.4 Protein containing a delta serrate ligand (DSL) domain, has low similarity to a region of C. elegans LAG-2, which appears to interact with C. elegans LIN-12 and C. elegans GLP-1 Notch receptors to influence cell fate decisions W09G12.5 W09G12.5 Protein containing an SRP54-type protein GTPase domain, has strong similarity to a region of signal recognition particle receptor (docking protein) (human SRPR), which binds the signal recognition particle in a complex with the ribosome GTP-binding protein W09G12.6 W09G12.6 Protein of unknown function, has weak similarity to C. elegans T28H11.1 W09G12.7 W09G12.7 Protein of unknown function, has weak similarity to human trans-Golgi network protein TGN51 (Hs. 14894) W09G12.8 W09G12.8 Protein with strong similarity to C. elegans F56G4.5 gene product W09G12.9 W09G12.9 Protein of unknown function W09G3.1 W09G3.1 Putative paralog of C. elegans W09G3.1A W09G3.2 W09G3.2 Protein with low similarity to macrophage erythroblast attacher (human MAEA), which attaches erythroblasts to macrophages and suppresses apoptosis of the erythroblasts W09G3.3 W09G3.3 Protein containing three regulator of chromosome condensation (RCC1) repeat domains W09G3.5 W09G3.5 Protein containing a DUF38 domain of unknown function, has low similarity to uncharacterized C. elegans Y37H2A.E W09G3.6 W09G3.6 Putative ortholog of C. elegans W09G3.1A gene product W09H1.1 W09H1.1 Protein of unknown function Dual specificity phosphatase, catalytic domain W09H1.2 W09H1.2 Member of the histone family of nucleosomal core proteins, has moderate similarity to centromere protein A (human CENPA), which is a histone H3-like protein that is an essential component of centromeres and a major autoantigen in some autoimmune diseases W09H1.3 W09H1.3 Protein with strong similarity to C. elegans F32A11.1 gene product W09H1.4 W09H1.4 Protein of unknown function W09H1.5 W09H1.5 Member of the alcohol dehydrogenase protein family, putative paralog of C. elegans Y48A6B.9 Zinc-binding dehydrogenases W09H1.6 lec-1;W09H1.6 Galectin, galactoside-binding lectin galectin; lec-1 encodes a tandem repeat-type galectin in which each galectin domain is homologous to typical vertebrate 14-kDa-type galectins; the two sugar binding sites have distinct sugar binding properties in vitro and lec-1 is expressed most abundantly in the adult cuticle. W10C6.1 mat-2;apc-1;evl-22;W10C6.1 Has strong similarity to S. cerevisiae Apc1p, a component of the anaphase-promoting complex (APC) that is required for cyclin degradation and for the metaphase-anaphase transition mat-2 encodes a subunit of the anaphase-promoting complex or cyclosome (APCC) which is a multi-subunit E3 ubiquitin ligase that targets proteins for degradation during the metaphase-to-anaphase transition of the cell cycle; mat-2 is required for chromosome segregation during meiosis I and is involved in polarity specification of the anterior/posterior axis in the developing embryo. W10C8.1 W10C8.1 Member of the dihydropyridine sensitive L-type calcium channel beta subunit family, contains a Src homology 3 (SH3) domain, which bind proline-rich peptides, has low similarity to a region of voltage-dependent calcium channel beta 4 subunit (human CACNB4) W10C8.3 W10C8.3 Protein of unknown function W10C8.4 W10C8.4 Protein containing a glutathione S-transferase C-terminal domain, which may be involved in conjugation of reduced glutathione to various targets W10C8.5 W10C8.5 Protein containing a plant ATP-guanido phosphotransferase N-terminal domain and an ATP:guanido phosphotransferase C-terminal catalytic domain, has moderate similarity to creatine kinase (muscle form, mouse Ckmm), which is important for energy homeostasis ATP transferase W10D5.1 mef-2;W10D5.1 Protein containing a SRF-type transcription factor (DNA-binding and dimerization domain) domain, which are involved in transcriptional regulation, has moderate similarity to myocyte enhancer factor 2A (mouse Mef2), which is a transcription factor MEF-2 protein; The mef-2 gene encodes the only MEF2 homolog in C. elegans, 'CeMEF2'; the alleged similarity of W04B5.3 to MEF2 is not well-attested. W10D5.2 W10D5.2 Member of the respiratory-chain NADH dehydrogenase 20 Kd subunit family, has high similarity to uncharacterized NADH dehydrogenase Fe-S protein 7 (human NDUFS7), which transports electrons from NADH to ubiquinone and is asociated with Leighs syndrome NADH-ubiquinone oxidoreductase 20 KD subunit; W10D5.2 is orthologous to the human gene NADH-UBIQUINONE OXIDOREDUCTASE Fe-S PROTEIN 7 (NDUFS7; OMIM:601825), which when mutated leads to Leigh syndrome (OMIM:256000). W10D5.3 W10D5.3 Protein containing three MIZ zinc finger domains, has a region of moderate similarity to a region of DEAD H box binding protein 1 (mouse Pias1), which binds and may inhibit the transcription activity of mouse Stat1 and may have a role in spermatogenesis gei-17 encodes a protein containing a MIZ domain (Msx-interacting-zinc finger) that affects embryonic viability, vulval development, and body morphology; interacts with GEX-3 in yeast two-hybrid assays. W10D9.1 W10D9.1 Protein of unknown function, has weak similarity to C. elegans W10D9.2 W10D9.2 W10D9.2 Protein containing an F-box domain, which serve as a link between a target protein and a ubiquitin-conjugating enzyme, has high similarity to uncharacterized C. elegans C24H12.11 This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins. W10D9.3 W10D9.3 Protein of unknown function W10D9.4 W10D9.4 Member of the eukaryotic histone-like transcription factor (CBF or NF-Y) and archaeal histone family, has a region of high similarity to a region of CCAAT binding transcription factor rat Nfyb W10D9.5 W10D9.5 Protein of unknown function W10G11.1 W10G11.1 Protein containing a DUF19 domain of unknown function, which contain twelve conserved cysteines, has high similarity to uncharacterized C. elegans W10G11.3 W10G11.10 W10G11.10 Member of the 7-transmembrane chemoreceptor family of G-protein coupled receptors (GPCR), has strong similarity to uncharacterized C. elegans W10G11.9 7TM chemoreceptor, srh family W10G11.11 W10G11.11 Protein containing a C-type lectin domain, which mediate calcium-dependent carbohydrate recognition W10G11.12 W10G11.12 Member of the C-type lectin family, has weak similarity to human C-type mannose receptor MRC1 W10G11.13 W10G11.13 Protein containing a C-type lectin domain, which mediate calcium-dependent carbohydrate recognition, has high similarity to uncharacterized C. elegans W10G11.14 W10G11.14 W10G11.14 Protein containing a C-type lectin domain, which mediate calcium-dependent carbohydrate recognition, has high similarity to uncharacterized C. elegans W10G11.15 W10G11.15 W10G11.15 Protein containing a C-type lectin domain, which mediate calcium-dependent carbohydrate recognition, has high similarity to uncharacterized C. elegans W10G11.14 W10G11.16 W10G11.16 Protein containing a neurotransmitter-gated ion-channel ligand binding domain, has low similarity to glycine receptor alpha 1 (human GLRA1), which is a subunit of the glycine-gated chloride channel that binds strychnine channel protein W10G11.17 W10G11.17 Protein of unknown function W10G11.19 W10G11.19 Protein of unknown function W10G11.2 W10G11.2 Protein containing a DUF19 domain of unknown function, which contain twelve conserved cysteines, has high similarity to uncharacterized C. elegans W10G11.1 W10G11.20 W10G11.20 Protein of unknown function W10G11.3 W10G11.3 Protein containing a DUF19 domain of unknown function, which contain twelve conserved cysteines, has high similarity to uncharacterized C. elegans W10G11.1 W10G11.4 W10G11.4 Protein containing two DUF19 domains of unknown function, which contain twelve conserved cysteines, has high similarity to uncharacterized C. elegans W10G11.3 W10G11.5 W10G11.5 Protein containing a C-type lectin domain, which mediate calcium-dependent carbohydrate recognition, has low similarity to uncharacterized C. elegans Y50D4B.5 W10G11.6 W10G11.6 Protein containing a C-type lectin domain, which mediate calcium-dependent carbohydrate recognition, has high similarity to uncharacterized C. elegans Y25C1A.4 W10G11.7 W10G11.7 Protein containing a C-type lectin domain, which mediate calcium-dependent carbohydrate recognition, has high similarity to uncharacterized C. elegans W10G11.6 W10G11.9 W10G11.9 Member of the 7-transmembrane chemoreceptor family of G-protein coupled receptors (GPCR), has strong similarity to uncharacterized C. elegans W10G11.10 7TM chemoreceptor, srh family W10G6.1 W10G6.1 Protein of unknown function, has strong similarity to C. elegans Y40H7A.7 W10G6.2 W10G6.2 Protein with high similarity to serum glucocorticoid regulated kinase (mouse Sgk), which is a putative serine-threonine kinase involved in sodium transport and stress response, contains a protein kinase domain and a protein kinase C-terminal domain Protein kinase C terminal domain W10G6.3 ifa-2;W10G6.3;Cel-IF-A2 Member of the intermediate filament family, which are components of the cytoskeleton and nuclear envelope, contains an intermediate filament tail domain, has low similarity to lamin B1 (mouse Lmnb1), which may be a structural member of the nuclear lamina intermediate filament protein; mua-6 encodes an essential intermediate filament protein (MUA-6/IFA-2) that is coexpressed with the essential IF protein IFB-1; MUA-6 is required for hypodermal integrity and for lasting attachment of muscles to the body wall; MUA-6 is also required for normal positioning of excretory canals and muscles; MUA-6 forms heteropolymeric intermediate filaments in vitro with an equimolar mixture of IFB-1; mua-6 is transcribed from L1 larval to adult stages; MUA-6 resides in main body hypodermal desmosomes, but not in seam cells. Y102A11A.1 Y102A11A.1 Putative ortholog of C. elegans Y102A11A.H gene product Y102A11A.2 Y102A11A.2 Putative ortholog of C. elegans Y102A11A.G gene product Y102A11A.3 Y102A11A.3 Putative ortholog of C. elegans Y102A11A.F gene product Y102A11A.6 Y102A11A.6 Putative ortholog of C. elegans Y102A11A.C gene product Y102A11A.8 Y102A11A.8 Putative ortholog of C. elegans Y102A11A.A gene product Y102A11A.B Y102A11A.7;Y102A11A.B Protein with strong similarity to C. elegans F59B10.3 gene product Y102A11A.D Y102A11A.5;Y102A11A.D Protein of unknown function Y102A11A.E Y102A11A.4;Y102A11A.E Putative ortholog of C. elegans B0302.3 gene product Y102A5A.1 Y102A5A.1 Protein with moderate similarity to TBP (TATA binding protein)-interacting protein 120A (rat Tip120A), which is a global transcription activator that interacts with TATA-binding protein and regulates transcription from polymerase 1, 2 and 3 promoters Y102A5B.1 Y102A5B.1 Member of the C-type lectin protein family Lectin C-type domain short and long forms (2 domains) Y102A5B.2 Y102A5B.2 Protein containing two C-type lectin domains, which mediate calcium-dependent carbohydrate recognition, has low similarity to a region of macrophage mannose receptor C1 (human MRC1), which acts in the uptake of microorganisms and host glycoproteins Lectin C-type domain short and long forms Y102A5B.3 Y102A5B.3 Member of the C-type lectin protein family Lectin C-type domain short and long forms Y102A5C.1 Y102A5C.1 Protein containing an F-box domain, which serve as a link between a target protein and a ubiquitin-conjugating enzyme, and a DUF38 domain of unknown function, has a region of weak similarity to C. elegans FOG-2, which is required for germ cell identity This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins; this gene's encoded protein also contains an FTH/DUF38 motif, which may also mediate protein-protein interaction. Y102A5C.10 Y102A5C.10 Protein containing an F-box domain, which serve as a link between a target protein and a ubiquitin-conjugating enzyme, has very strong similarity to uncharacterized C. elegans Y102A5C.12 This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins. Y102A5C.12 Y102A5C.12 Protein containing an F-box domain, which serve as a link between a target protein and a ubiquitin-conjugating enzyme, has low similarity to a region of C. elegans T07D3.1, which may function in germ-line stem cell differentiation This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins. Y102A5C.13 Y102A5C.13 Protein containing a DUF38 domain of unknown function, has moderate similarity to a region of C. elegans FOG-2, which is required for the sexual identity of germ cells Y102A5C.14 Y102A5C.14 Protein containing an F-box domain, which serve as a link between a target protein and a ubiquitin-conjugating enzyme, and a DUF38 domain of unknown function, has moderate similarity to C. elegans FOG-2, which is required for germ cell sexual identity This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins; this gene's encoded protein also contains an FTH/DUF38 motif, which may also mediate protein-protein interaction. Y102A5C.15 Y102A5C.15 Member of the 7-transmembrane chemoreceptor family of G-protein coupled receptors (GPCR), has high similarity to uncharacterized C. elegans ZK262.1 G-protein coupled receptor, srh family Y102A5C.16 Y102A5C.16 Protein containing a C-type lectin domain, which mediate calcium-dependent carbohydrate recognition, has high similarity to uncharacterized C. elegans Y102A5C.17 Lectin C-type domain Y102A5C.17 Y102A5C.17 Protein containing a C-type lectin domain, which mediate calcium-dependent carbohydrate recognition, has strong similarity to uncharacterized C. elegans Y102A5C.7 Lectin C-type domain Y102A5C.18 efl-1;Y102A5C.18 Member of the transcription factor E2F-dimerization partner (TDP) family, which stimulate E2F-dependent transcription, has a region of moderate similarity to a region of E2F transcription factor 4 (human E2F4), which is a cell cycle regulator efl-1 encodes a homolog of mammalian E2F that is required for embryonic asymmetry and that functions as a transcriptional repressor; during vulval development, efl-1, a class B synMuv gene, acts with class B synMuv genes dpl-1 and lin-35/Rb to antagonize receptor tyrosine kinase and Ras-mediated signaling; EFL-1 also negatively regulates the G1 to S phase cell cycle transition. Y102A5C.19 Y102A5C.19 Protein containing an F-box domain, which serve as a link between a target protein and a ubiquitin-conjugating enzyme, and a DUF38 domain of unknown function, has low similarity to C. elegans FOG-2, which is required for the sexual identity of germ cells This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins; this gene's encoded protein also contains an FTH/DUF38 motif, which may also mediate protein-protein interaction. Y102A5C.2 Y102A5C.2 Protein of unknown function Y102A5C.20 Y102A5C.20 Protein containing a DUF40 domain of unknown function, which contain four conserved cysteines Y102A5C.21 Y102A5C.21 Member of the 7-transmembrane chemoreceptor family of G-protein coupled receptors (GPCR), has high similarity to uncharacterized C. elegans F08E10.3 G-protein coupled receptor, srh family Y102A5C.22 Y102A5C.22 Member of the rhodopsin family of G-protein coupled receptors (GPCR), has high similarity to uncharacterized C. elegans Y102A5C.24 7TM receptor, srx family Y102A5C.23 Y102A5C.23 Protein containing a DUF216 domain of unknown function, has high similarity to uncharacterized C. elegans Y102A5C.25 Y102A5C.24 Y102A5C.24 Member of the rhodopsin family of G-protein coupled receptors (GPCR), has high similarity to uncharacterized C. elegans Y102A5C.22 7 transmembrane receptor (rhodopsin family) Y102A5C.25 Y102A5C.25 Protein containing a DUF216 domain of unknown function, has high similarity to uncharacterized C. elegans Y102A5C.26 Y102A5C.26 Y102A5C.26 Protein containing a DUF216 domain of unknown function, has high similarity to uncharacterized C. elegans Y102A5C.25 Y102A5C.27 Y102A5C.27 Protein of unknown function, has weak similarity to C. elegans Y68A4B.3 Y102A5C.28 Y102A5C.28 Member of the 7-transmembrane chemoreceptor family of G-protein coupled receptors (GPCR), has high similarity to uncharacterized C. elegans C55A1.1 G-protein coupled receptor, str family Y102A5C.29 Y102A5C.29 Member of the 7-transmembrane chemoreceptor family of G-protein coupled receptors (GPCR), has high similarity to uncharacterized C. elegans ZK666.10 7TM chemoreceptor, sri family Y102A5C.3 Y102A5C.3 Protein containing an F-box domain, which serve as a link between a target protein and a ubiquitin-conjugating enzyme, and a DUF38 domain of unknown function, has low similarity to C. elegans T07D3.1, which may act in germ-line stem cell differentiation Y102A5C.3 is orthologous to the human gene HISTIDINE-RICH GLYCOPROTEIN (HRG), which when mutated leads to thrombophilia (OMIM:142640). Y102A5C.31 Y102A5C.31 Member of the 7-transmembrane chemoreceptor family of G-protein coupled receptors (GPCR), has strong similarity to uncharacterized C. elegans T27C5.5 G-protein coupled receptor, srh family Y102A5C.32 Y102A5C.32 Member of the 7-transmembrane chemoreceptor family of G-protein coupled receptors (GPCR), has strong similarity to uncharacterized C. elegans Y61B8B.1 7TM chemoreceptor, sri family Y102A5C.33 Y102A5C.33 Protein containing a DUF216 domain of unknown function, has high similarity to uncharacterized C. elegans F49H6.10 Y102A5C.4 Y102A5C.4 Protein of unknown function, has moderate similarity to uncharacterized C. elegans B0462.1 Y102A5C.7 Y102A5C.7 Protein containing a C-type lectin domain, which mediate calcium-dependent carbohydrate recognition, has strong similarity to uncharacterized C. elegans Y102A5C.17 Lectin C-type domain Y102A5C.8 Y102A5C.8 Protein containing a DUF38 domain of unknown function and an F-box domain, which serve as a link between a target protein and a ubiquitin-conjugating enzyme, has low similarity to C. elegans FOG-2, which is required for the sexual identity of germ cells This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins; this gene's encoded protein also contains an FTH/DUF38 motif, which may also mediate protein-protein interaction. Y102A5C.9 Y102A5C.9 Protein containing a DUF38 domain of unknown function, has moderate similarity to C. elegans FOG-2, which is required for the sexual identity of germ cells Y102A5D.1 Y102A5D.1 Putative ortholog of C. elegans T26G10.4 gene product Y102E9.1 odr-4;Y102E9.1 Membrane-associated protein involved in localization of odorant receptors to olfactory neuron cilia odr-4 encodes a novel type II membrane protein required for the localization of a subset of seven transmembrane domain odorant receptors, including ODR-10, to the cilia of olfactory neurons, it affects response to a subset of AWA- and AWC- mediated olfactory responses, and is required for social feeding of npr-1 mutant animals; expressed in 12 pairs of chemosensory neurons. Y102E9.2 Y102E9.2 Protein of unknown function Y102E9.3 Y102E9.3 Protein of unknown function Y102E9.4 Y102E9.4 Protein of unknown function Y102F5A.1 Y102F5A.1 Protein of unknown function Y104H12BL.A Y104H12BL.1;Y104H12BL.A Protein with weak similarity to C. elegans Y110A2AM.1 gene product Y104H12BR.1 Y104H12BR.1 Putative ortholog of C. elegans Y104H12BR.B gene product Y104H12D.1 Y104H12D.1 Putative paralog of C. elegans Y104H12D_376.A decarboxylase Y104H12D.2 Y104H12D.2 Protein of unknown function Y104H12D.3 Y104H12D.3 Putative ortholog of C. elegans Y104H12D_376.A gene product Y105C5A.11 Y105C5A.11 Protein of unknown function, putative paralog of C. elegans ZC204.4 G-protein coupled receptor, srg family Y105C5A.14 Y105C5A.14 Protein of unknown function, putative paralog of C. elegans Y105C5.N Y105C5A.15 Y105C5A.15 Protein of unknown function, has moderate similarity to C. elegans Y105C5.Q Y105C5A.16 Y105C5A.16 Protein of unknown function, putative paralog of C. elegans Y105C5.S Y105C5A.17 Y105C5A.17 Protein with weak similarity to C. elegans F55C12.7 gene product Y105C5A.23 Y105C5A.23 Putative paralog of C. elegans Y105C5.V Y105C5A.25 Y105C5A.25 Protein of unknown function, has moderate similarity to C. elegans Y105C5.Z Y105C5A.5 Y105C5.D;Y105C5A.D;Y105C5A.5 Protein of unknown function, has very strong similarity to uncharacterized C. elegans Y105C5.E The protein product of this gene is predicted to contain a glutamine/asparagine (Q/N)-rich ('prion') domain, by the algorithm of Michelitsch and Weissman (as of the WS77 release of WormBase, i.e., in wormpep77). Y105C5A.6 Y105C5.E;Y105C5A.B;Y105C5A.E;Y105C5A.3;Y105C5A.6 Protein of unknown function, has very strong similarity to uncharacterized C. elegans Y105C5.D The protein product of this gene is predicted to contain a glutamine/asparagine (Q/N)-rich ('prion') domain, by the algorithm of Michelitsch and Weissman (as of the WS77 release of WormBase, i.e., in wormpep77). Y105C5A.8 Y105C5.G;Y105C5A.G;Y105C5A.8 Protein of unknown function, has low similarity to uncharacterized C. elegans C39E9.8 Y105C5A.L Y105C5A.13;Y105C5A.12;Y105C5A.K;Y105C5A.L Protein with strong similarity to C. elegans Y105C5.L gene product Y105C5B.13 skr-10;Y105C5B.13 Putative ortholog of C. elegans skr-9 gene product skr-10 encodes a homolog of Skp1 in S. cerevisiae, a core component of the SCF (Skp1p, Cullin, F-box) ubiquitin-ligase complex that facilitates ubiquitin-mediated protein degradation; SKR-10 is required for posterior body morphogenesis, embryonic and larval development, and cell proliferation; SKR-10 is expressed in the tip and end regions of the intestine and can interact in vivo with CUL-1 and CUL-2, C. elegans cullin homologs. Y105C5B.19 Y105C5B.19 Putative ortholog of C. elegans M199.2 gene product Y105C5B.2 gcy-25;Y105C5B.2 Member of the guanylyl cyclase family of membrane associated proteins gcy-25 encodes a predicted guanylate cyclase. Y105C5B.21 p120;Y105C5B.21 Putative member of the beta-catenin family jac-1 encodes the C. elegans p120 catenin orthologue; by homology, JAC-1 is predicted to be a component of the cadherin-catenin complex (CCC); although loss of jac-1 activity via RNAi does not result in obvious defects, jac-1(RNAi) does enhance embryonic morphogenesis defects produced by weak loss-of-function mutations in hmp-1/alpha-catenin, suggesting that JAC-1 positively regulates cadherin-catenin function in the embryo; JAC-1 likely regulates this function by promoting association between the actin cytoskeleton and the cadherin-catenin complex; a JAC-1 reporter fusion localizes to embryonic adherens junctions in a manner that is dependent upon the presence of HMR-1/cadherin, with which it specifically interacts in the yeast two-hybrid system. Y105E8A.12 Y105E8A.12 Putative ortholog of C. elegans C02E7.1 gene product Y105E8A.14 Y105E8A.14 Putative ortholog of C. elegans Y105E8E.R gene product Y105E8A.15 Y105E8A.15 Protein of unknown function Y105E8A.16 Y105E8A.16 Putative ortholog of C. elegans Y105E8E.S gene product rps-20 encodes a small ribosomal subunit S20 protein. Y105E8A.17 Y105E8A.17 Putative ortholog of C. elegans Y105E8E.T gene product Y105E8A.18 Y105E8A.18 Putative ortholog of C. elegans Y105E8E.U gene product Y105E8A.19 Y105E8A.19 Putative ortholog of C. elegans Y105E8E.V gene product Y105E8A.20 Y105E8A.20 Putative ortholog of C. elegans Y105E8E.W gene product Y105E8A.22 Y105E8A.22 Protein with moderate similarity to C. elegans Y105E8E.Y gene product chloride channel; exc-4 encodes a highly conserved member of the chloride intracellular channel (CLIC) family of anion channels; EXC-4 is required during early stages of excretory cell tubulogenesis and appears also to play a role in vulval and seam cell development, which subsequently affects viability, fertility, and locomotion; EXC-4 is localized to the apical/lumenal membrane of the excretory cell and is also expressed in the hypodermis, vulva, and rectal gland cell. Y105E8A.23 Y105E8A.23 Putative ortholog of C. elegans Y105E8C.C gene product Y105E8A.24 Y105E8A.24 Putative ortholog of C. elegans Y105E8C.D gene product Y105E8A.25 Y105E8A.25 Putative ortholog of C. elegans Y105E8A.GG gene product Y105E8A.3 Y105E8A.3 Putative ortholog of C. elegans Y105E8F.a gene product Y105E8A.7 Y105E8A.7 Putative ortholog of C. elegans Y105E8E.F gene product eat-18 encodes a YEATS family protein, homologous to mammalian YNK7, ENL, AF-9, and TFIIF, that is expected to be a transcriptional activator; EAT-18 is expressed in pharyngeal muscle, is required for neurotransmission by the MC pharyngeal neuron; eat-18 interacts genetically with eat-2, which encodes a nAChR beta subunit also expressed in pharyngeal muscle. Y105E8A.8 Y105E8A.8 Putative ortholog of C. elegans Y105E8E.I gene product Y105E8A.9 Y105E8A.9 Putative ortholog of C. elegans Y105E8E.J gene product The apt-1 gene encodes an adaptin: specifically, it encodes an ortholog of the gamma subunit of adaptor protein complex 1 (AP-1). Y105E8A.AA Y105E8A.21;Y105E8A.AA Putative ortholog of C. elegans Y105E8E.X gene product Y105E8A.B Y105E8A.1;Y105E8A.B Protein of unknown function Y105E8A.BB Y105E8A.BB Putative ortholog of C. elegans Y105E8E.Y gene product Y105E8A.C Y105E8A.2;Y105E8A.C Protein of unknown function, has low similarity to uncharacterized human CL25084 Y105E8A.E Y105E8A.4;Y105E8A.E Protein with high similarity to short chain enoyl-Coenzyme A hydratase 1 (rat Echs1), which catalyzes the hydration of trans-2-enoyl-CoA forming 3-hydroxyacyl-CoA in fatty acid beta-oxidation, member of the enoyl-CoA hydratase or isomerase family Y105E8A.F Y105E8A.5;Y105E8A.F Putative ortholog of C. elegans Y105E8E.C gene product Y105E8A.H Y105E8A.6;Y105E8A.H Protein containing a LIM domain, which may mediate protein-protein interactions Y105E8A.HH Y105E8A.HH Protein with strong similarity to C. elegans Y105E8B.A gene product Y105E8A.JJ Y105E8A.JJ Protein of unknown function Y105E8A.KK Y105E8A.KK Protein with weak similarity to C. elegans Y105E8B.C gene product Y105E8A.LL Y105E8A.LL Putative ortholog of C. elegans Y105E8B.2 gene product Y105E8A.MM Y105E8A.MM Putative ortholog of C. elegans Y105E8B.E gene product Y105E8A.NN Y105E8A.NN Putative ortholog of C. elegans Y105E8B.7 gene product Y105E8A.OO Y105E8A.OO Putative ortholog of C. elegans Y105E8B.4 gene product Y105E8A.P Y105E8A.11;Y105E8A.P Protein containing a BolA-like protein domain, which may be involved in controlling cell morphology, has moderate similarity to uncharacterized C. albicans Orf6.7573p Y105E8A.PP Y105E8A.PP Putative ortholog of C. elegans Y105E8B.H gene product Y105E8A.QQ Y105E8A.QQ Protein with strong similarity to C. elegans Y105E8B.I gene product Y105E8A.RR Y105E8A.RR Putative ortholog of C. elegans Y105E8B.5 gene product Y105E8A.SS Y105E8A.SS Protein with weak similarity to C. elegans Y105E8B.6 gene product Y105E8A.T Y105E8A.13;Y105E8A.T Putative ortholog of C. elegans Y105E8E.Q gene product Y105E8A.TT Y105E8A.TT Putative ortholog of C. elegans Y105E8B.L gene product Y105E8A.UU Y105E8A.UU Putative ortholog of C. elegans Y105E8B.M gene product Y105E8A.VV Y105E8A.VV Putative ortholog of C. elegans Y105E8B.N gene product Y105E8A.WW Y105E8A.WW Protein with strong similarity to C. elegans Y105E8B.O gene product Y105E8B.1 Y105E8B.1 Protein of unknown function lev-11 encodes tropomyosin, an actin-binding contractile structural protein orthologous to human TROPOMYOSIN 1 (TPM1; OMIM:191010), which when mutated leads to familial hypertrophic cardiomyopathy; LEV-11 is required for embryonic development, normal body morphology, and locomotion; expressed as multiple tissue-specific isoforms generated by alternative mRNA splicing and promoter use, LEV-11 is detected in several tissues including muscle, pharynx, intestine, and the germ line. Y105E8B.2 Y105E8B.2 Putative ortholog of C. elegans Y105E8A.LL gene product Y105E8B.3 Y105E8B.3 Putative ortholog of C. elegans Y105E8B.H gene product Y105E8B.8 Y105E8B.8 Putative ortholog of C. elegans Y105E8B.M gene product ero-1 encodes an endoplasmic reticulum oxidoreductase that affects ER-stress response and affects reactive oxygen species levels. Y105E8B.9 Y105E8B.9 Putative ortholog of C. elegans Y105E8A.VV gene product Y105E8B.9 is orthologous to the human gene GLUTATHIONE TRANSFERASE ZETA 1 (MALEYLACETOACETATE ISOMERASE) (GUSB; OMIM:603758), which when mutated leads to disease. Y105E8B.D Y105E8A.10;Y105E8A.O;Y105E8B.D Protein of unknown function, has moderate similarity to uncharacterized C. elegans R08F11.1 Y105E8B.F Y105E8B.7;Y105E8B.F Protein with weak similarity to S. cerevisiae YAF9 (Protein with similarity to human AF-9 protein) Y105E8B.G Y105E8B.4;Y105E8B.G Putative ortholog of C. elegans Y105E8A.OO gene product Y105E8B.J Y105E8B.5;Y105E8B.J Putative ortholog of C. elegans Y105E8A.RR gene product Y105E8B.K Y105E8B.6;Y105E8B.K Protein with weak similarity to C. elegans Y105E8A.SS gene product Y106G6A.1 Y106G6A.1 Protein containing a protein kinase domain, has a region of low similarity to a region of mitogen activated protein kinase kinase kinase 3 (human MAP3K3), which activates the SAPK (MAPK8) and ERK (MAPK3) but not the p38 MAP kinase (MAPK14) pathway serine/threonine kinase Y106G6A.2 Y106G6A.2 Protein of unknown function Y106G6A.3 Y106G6A.3 Protein of unknown function Y106G6A.4 Y106G6A.4 Protein of unknown function Y106G6A.5 Y106G6A.5 Protein of unknown function Y106G6D.1 Y106G6D.1 Protein with weak similarity to S. cerevisiae MYO1 (Myosin heavy chain (myosin II), coiled-coil protein involved in septation and cell wall organization) Y106G6D.2 Y106G6D.2 Protein with weak similarity to S. cerevisiae USO1 (Coiled-coil protein with similarity to mammalian integrin, required for protein transport from ER to Golgi) Y106G6D.3 Y106G6D.3 Protein of unknown function, has weak similarity to a number of different proteins Y106G6D.4 Y106G6D.4 Protein containing a protein kinase domain, has a region of low similarity to a region of glycogen synthase kinase-3 beta (mouse Gsk3b), which is a serine threonine protein kinase that is involved in embryonic development serine/threonine kinase Y106G6D.5 Y106G6D.5 Protein of unknown function, has low similarity to a region of immunoglobulin mu binding protein 2 (human IGHMBP2), which is a DNA binding protein that functions as a transcriptional regulator and may be involved in viral defense mechanisms Y106G6D.6 Y106G6D.6 Protein with moderate similarity to C. elegans Y106G6D.4 gene product Y106G6D.7 Y106G6D.7 Protein containing an RNA recognition motif (RRM, RBD, or RNP), has weak similarity to uncharacterized human RBM12 RNA recognition motif. (aka RRM, RBD, or RNP domain) Y106G6E.1 Y106G6E.1 Protein containing two protein kinase domains, has low similarity to C. elegans GSK-3, which is a serine/threonine protein kinase that is required for proper spindle orientation and polarization of the EMS blastomere Helix-loop-helix DNA-binding domain, serine/threonine kinase Y106G6E.2 Y106G6E.2 Putative ortholog of C. elegans B0379.7 gene product Y106G6E.3 Y106G6E.3 Protein of unknown function, has very strong similarity to uncharacterized C. elegans B0379.2 Y106G6E.4 Y106G6E.4 Member of the 5-formyltetrahydrofolate cyclo-ligase family, which are involved in 5-10-methenyltetrahydrofolate biosynthesis, has moderate similarity to 5,10-methenyltetrahydrofolate synthetase (5-formyltetrahydrofolate cyclo-ligase, human MTHFS) 5-formyltetrahydrofolate cyclo-ligase; This gene encodes a protein predicted by Eisenberg and coworkers, with 52% accuracy, to be mitochondrial. Y106G6E.5 ced-12;Y106G6E.5 Similar to mammalian ELMO proteins, involved in cell- corpse engulfment, cell migration, and development ced-12 is required both for phagocytotic engulfment of dying (apoptotic) cells, and for normal migrations of healthy cells during development. Y106G6E.6 Y106G6E.6 Serine/threonine protein kinase of the casein kinase I subfamily, has similarity to S. cerevisiae Yck1p and Yck2p casein kinase I isoforms casein kinase like Y106G6G.1 Y106G6G.1 Putative ortholog of C. elegans ZC434.1 gene product Y106G6G.2 Y106G6G.2 Putative ortholog of C. elegans T20F10.3 gene product Y106G6G.3 Y106G6G.3 Protein of unknown function Y106G6G.4 Y106G6G.4 Protein of unknown function Y106G6G.5 Y106G6G.5 Putative ortholog of C. elegans Y26D4A.9 gene product Y106G6H.1 Y106G6H.1 Protein of unknown function Y106G6H.10 Y106G6H.10 Protein containing an F-box domain, which serve as a link between a target protein and a ubiquitin-conjugating enzyme This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins. Y106G6H.12 Y106G6H.12 Member of the ubiquitin carboxyl-terminal hydrolase family 2, and of the ovarian tumor (OTU)-like cysteine protease family, contains a ubiquitin carboxyl-terminal hydrolases family 2 domain, has low similarity to uncharacterized C. elegans F38B7.5 Ubiquitin carboxyl-terminal hydrolases family 2 Y106G6H.13 Y106G6H.13 Protein of unknown function Y106G6H.14 Y106G6H.14 Protein with high similarity to osteoclast stimulating factor (human OSTF1), which indirectly stimulates osteoclast formation and enhances 1,25 dihydroxyvitamin D3-induced bone resorption, contains 3 ankyrin (Ank) repeats and a Src homology 3 domain Src homology domain 3 ; Ank repeat Y106G6H.15 Y106G6H.15 Protein of unknown function Y106G6H.2 Y106G6H.2 Protein with high similarity to poly(A)-binding protein cytoplasmic 1 (human PABPC1), which binds to mRNA poly(A) tails, contains four RNA recognition motifs (RRM, RBD, or RNP) and one polyadenylate binding protein (PABP) unique domain RNA recognition motif. (aka RRM, RBD, or RNP domain) ; Poly-adenylate binding protein, unique domain.; pab-1 encodes a polyadenylate-binding protein (i.e., poly(A)-binding protein, or PAB); while not extensively characterized, PAB-1 has been successfully used as an epitope-tagged transgenic reagent for tissue-specific isolation of mRNAs. Y106G6H.3 Y106G6H.3 Protein with high similarity to 60S ribosomal protein L30 (S. pombe Rpl30p), which binds DNA, member of the ribosomal L7Ae, L30e, S12e or Gadd45 family, which include ribosomal as well as growth control proteins rpl-30 encodes a large ribosomal subunit L30 protein; by homology, RPL-30 is predicted to function in protein biosynthesis; in C. elegans, loss of rpl-30 function via RNA-mediated interference (RNAi) does not result in any obvious abnormalities. Y106G6H.4 Y106G6H.4 Protein with moderate similarity to C. elegans F36D1.1 gene product Y106G6H.5 Y106G6H.5 Member of the glycine cleavage T-protein (aminomethyl transferase) family, has low similarity to sarcosine dehydrogenase (rat Sardh), which is a flavoenzyme that catalyzes the oxidative demethylation of sarcosine and is involved in choline catabolism The Y106G6H.5 gene encodes a homolog of the human gene SARDH, which when mutated leads to sarcosinemia, (OMIM:268900). Y106G6H.6 Y106G6H.6 Protein of unknown function Y106G6H.7 sec-8;Y106G6H.7 Protein with low similarity to secretory protein 8 (human SEC8), which may be part of a complex involved in basolateral cargo delivery and is absent from basolateral membranes of kidney cells in patients with autosomal dominant polycystic kidney disease The sec-8 gene encodes an ortholog of SEC8 in S. cerevisiae, a component of the exocyst complex required genetically for endocytosis, for normal cellular morphology in the intestine, and for growth at normal rates during development. Y106G6H.8 Y106G6H.8 Protein of unknown function Y106G6H.9 Y106G6H.9 Protein containing an F-box domain, which serve as a link between a target protein and a ubiquitin-conjugating enzyme This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins. Y108G3AL.6 Y108G3AL.6 Protein of unknown function Y108G3AL.A Y108G3AL.5;Y108G3AL.A Protein of unknown function Y108G3AL.D Y108G3AL.3;Y108G3AL.D Putative ortholog of C. elegans W01A6.I gene product Y108G3AL.F Y108G3AL.2;Y108G3AL.F Putative ortholog of C. elegans W01A6.H gene product Y10G11A.A Y10G11A.A Protein with strong similarity to C. elegans F25B5.3 gene product Y10G11A.B Y10G11A.B Protein with strong similarity to C. elegans F25B5.3 gene product Y10G11A.C Y10G11A.C Protein of unknown function Y110A2AL.1 Y110A2AL.1 Protein of unknown function, putative paralog of C. elegans Y110A2AL.10 Y110A2AL.10 Y110A2AL.10 Protein of unknown function, putative paralog of C. elegans Y110A2AL.1 Y110A2AL.11 Y110A2AL.11 Protein with weak similarity to D. melanogaster CG18173 (CG18173 gene product) Y110A2AL.12 Y110A2AL.12 Protein with weak similarity to D. melanogaster CG18173 (CG18173 gene product) Y110A2AL.13 Y110A2AL.13 Protein with strong similarity to C. elegans Y65B4BR.4 Y110A2AL.14 Y110A2AL.14 Protein with strong similarity to H. sapiens BETA3GNT (beta-1,3-N-acetylglucosaminyltransferase) sqv-2 encodes a glycosaminoglycan galactosyltransferase II, biochemically active in vitro, that is required for cytokinesis of one-cell embryos and for vulval morphogenesis; the common requirement for SQV-2 in both cytokinesis and morphogenesis may be to promote filling an extracellular space with hygroscopic proteoglycans (either in the eggshell, or underneath the L4 cuticle), which in turn may cause the space to fill with fluid. Y110A2AL.2 Y110A2AL.2 Protein with moderate similarity to C. elegans F08D12.3 Y110A2AL.3 Y110A2AL.3 Protein of unknown function, has strong similarity to C. elegans Y110A2A_54.J Y110A2AL.4 Y110A2AL.4 Protein of unknown function, putative paralog of C. elegans Y110A2AL.7 Y110A2AL.5 Y110A2AL.5 Protein of unknown function, putative paralog of C. elegans Y110A2A_54.J Y110A2AL.6 Y110A2AL.6 Protein of unknown function, has strong similarity to C. elegans Y110A2AL.7 Y110A2AL.7 Y110A2AL.7 Protein of unknown function, putative paralog of C. elegans Y110A2AL.4 Y110A2AL.8 ptc-3;Y110A2AL.8 Putative ortholog of D. melanogaster ptc (patched) Y110A2AL.9 Y110A2AL.9 Protein with weak similarity to C. elegans K04H4.2 (Protein with weak similarity to human and D. melanogaster NOTCH proteins) Y110A2AM.1 Y110A2AM.1 Putative ortholog of C. elegans Y110A2AM.A gene product Y110A2AM.2 Y110A2AM.2 Protein with moderate similarity to C. elegans ama-1 gene product Y110A2AR.1 Y110A2AR.1 Protein with weak similarity to H. sapiens D5S346 (DNA segment, single copy probe LNS-CAI/LNS-CAII (deleted in polyposis) Y110A2AR.2 Y110A2AR.2 Protein with strong similarity to S. cerevisiae UBC6 (Ubiquitin-conjugating enzyme) ubc-15 encodes an E2 ubiquitin-conjugating enzyme predicted to mediate the covalent attachment of an activated ubiquityl moiety to a substrate protein; as loss of UBC-15 activity via RNA-mediated interference (RNAi) does not result in any abnormalities, the precise role of UBC-15 in C. elegans development and/or behavior is not yet known; by sequence similarity, however, UBC-15 is predicted to function in protein modification and turnover. Y110A2AR.3 Y110A2AR.3 Protein with strong similarity to D. melanogaster CG9132 (CG9132 gene product) Y110A7A.1 Y110A7A.1 Protein of unknown function hcp-6 encodes a HEAT motif-containing protein that displays similarity to the XCAP-D2/CNAP1/Cnd1/YCS4 family of proteins that are homologous to the condensin complex subunit 1; HCP-6 activity is required during mitosis for some aspects of mitotic chromosome condensation, attachment of microtubules to kinetochores, mitotic chromosome alignment, and mitotic sister chromatid segregation; during interphase, HCP-6 is detectable in a punctate pattern in the nucleoplasm; at prophase, HCP-6 becomes associated with condensed chromosomes, colocalizing with the centromeric component HCP-3; HCP-6 localization to chromosomes depends upon the activity of HCP-3 and HCP-4, a C. elegans CENP-C-like protein. Y110A7A.17 mat-1;Y110A7A.D;Y110A7A.17 Similar to S. cerevisiae anaphase-producing complex (APC); mutations cause defects in metaphase to anaphase transitions Y110A7A.5 Y110A7A.5 Protein with strong similarity to human MTM1 myotubularin, which is associated with X-linked myotubular myopathy myotubularin-like protein; mtm-1 encodes an ortholog of human myotubularin (MTM1), which when mutated leads to myotubular myopathy (OMIM:310400); mtm-1(RNAi)suppresses the endocytosis defect of let-512 mutants, indicating that MTM-1 negatively regulates LET-512 (a phosphatidylinositol 3-kinase orthologous to yeast Vps34). Y110A7A.I Y110A7A.20;Y110A7A.I Protein of unknown function Y110A7A.O Y110A7A.6;Y110A7A.O Putative ortholog of C. elegans K02B2.1 gene product Y111B2A.11 Y111B2A.11 Putative ortholog of C. elegans Y111B2A.I gene product Y111B2A.12 Y111B2A.12 Putative ortholog of C. elegans Y111B2G.B gene product Y111B2A.14 Y111B2A.14 Putative ortholog of C. elegans Y111B2D.A gene product The protein product of this gene is predicted to contain a glutamine/asparagine (Q/N)-rich ('prion') domain, by the algorithm of Michelitsch and Weissman (as of the WS77 release of WormBase, i.e., in wormpep77). Y111B2A.16 taf8.2;Y111B2G.G;Y111B2A.16 Has similarity to a human TAFII Y111B2A.17 Y111B2A.17 Putative ortholog of C. elegans Y111B2A.O gene product Y111B2A.18 Y111B2A.18 Putative ortholog of C. elegans Y111B2D.f gene product splicing factor; rsp-3 encodes a putative ortholog of human SF2/ASF and member of the SR protein family of nuclear phosphoproteins that are required for constitutive splicing and influence alternative splicing regulation; rsp-3 affects the development of oocytes together with rsr-1, and is required for late embryonic viability; SPK-1 binds directly to and phosphorylates the RS domain of RSP-3 in vitro and the mRNA of rsp-3 is predominantly expressed in the germline. Y111B2A.19 Y111B2A.19 Putative ortholog of C. elegans Y111B2A.L gene product Y111B2A.2 Y111B2A.2 Protein with strong similarity to C. elegans F29C4.2 gene product Y111B2A.20 Y111B2A.20 Putative ortholog of C. elegans Y111B2E.B gene product Y111B2A.21 Y111B2A.21 Putative ortholog of C. elegans Y111B2B.A gene product Y111B2A.23 Y111B2A.23 Putative ortholog of C. elegans Y111B2A.R gene product Y111B2A.24 Y111B2A.24 Putative ortholog of C. elegans Y111B2E.A gene product Y111B2A.25 Y111B2A.25 Protein of unknown function Y111B2A.3 Y111B2A.3 Putative ortholog of C. elegans B0035.6 gene product Y111B2A.5 Y111B2A.5 Protein of unknown function Y111B2A.8 Y111B2A.8 Protein with strong similarity to C. elegans Y41G9A.3 gene product Y111B2A.8 is orthologous to the human gene AMP-ACTIVATED PROTEIN KINASE GAMMA SUBUNIT (PRKAG2; OMIM:602743), which when mutated leads to disease. Y111B2A.9 Y111B2A.9 Putative ortholog of C. elegans Y111B2C.J gene product Y111B2A.A Y111B2A.1;Y111B2A.A Protein containing a protein kinase domain, has low similarity to P. carinii Mkp2_carinii, which is a mitogen-activated protein kinase Y111B2A.C Y111B2A.4;Y111B2A.C Protein with strong similarity to C. elegans Y111B2A.E gene product Y111B2A.CC Y111B2A.22;Y111B2A.CC Putative ortholog of C. elegans Y111B2C.A gene product Y111B2A.J Y111B2A.7;Y111B2A.J Protein containing an SNF2 related N-terminal domain Y111B2A.V TPST-A;Y111B2A.15;Y111B2A.V Tyrosylprotein sulfotransferase Y113G7A.1 Y113G7A.1 Putative ortholog of C. elegans T26H5.3 gene product Y113G7A.10 Y113G7A.10 Putative ortholog of C. elegans Y113G7A.B gene product Y113G7A.11 Y113G7A.11 Member of the sulfotransferase family, has low similarity to hydroxysteroid sulfotransferase cytosolic 2B1 (human SULT2B1), which catalyzes the transfer of sulfonate from 3'-phosphoadenosine 5'-phosphosulfonate to cholesterol and dehydroepiandrosterone Y113G7A.12 Y113G7A.12 Protein with strong similarity to C. elegans Y113G7A.S Y113G7A.13 Y113G7A.13 Protein of unknown function, has strong similarity to C. elegans Y113G7A.T Y113G7A.14 Y113G7A.14 Protein of unknown function Y113G7A.15 Y113G7A.15 Protein with strong similarity to C. elegans Y113G7A.M gene product Y113G7A.3 Y113G7A.3 Putative ortholog of C. elegans Y113G7A.N gene product Y113G7A.4 Y113G7A.4 Protein with high similarity to solute carrier family 8 member 2 (sodium-calcium exchanger, rat Ncx2), which exports calcium from the cytosol to the extracellular matrix, member of the sodium or calcium exchanger protein family of membrane transporters Y113G7A.5 Y113G7A.5 Putative ortholog of C. elegans gbr-6 gene product Y113G7A.6 ttx-1;Y113G7A.6 Homeodomain protein involved in thermotaxis and specification of thermosensory neuron fate Y113G7A.8 Y113G7A.8 Member of the flavodoxin family of electron-transfer proteins, contains a FAD binding domain and an oxidoreductase FAD or NAD-binding domain, has moderate similarity to NADPH-dependent FMN and FAD containing oxidoreductase (human NR1) Y113G7A.9 Y113G7A.K;Y113G7A.9 Protein of unknown function, has moderate similarity to uncharacterized human HSPC015 Y113G7B.11 Y113G7B.11 Protein of unknown function Y113G7B.12 Y113G7B.12 Member of the reverse transcriptase protein family, which are RNA-dependent DNA polymerases, has a region of low similarity to a region of S. cerevisiae Srp40p, which is a nucleolar protein Y113G7B.14 Y113G7B.14 Protein containing an SNF2 related N-terminal domain, has low similarity to a region of transcription termination factor RNA polymerase II (human TTF2), which is an ATPase involved in transcription termination, transcriptional activation and repression Y113G7B.15 Y113G7B.15 Member of the papain family of cysteine proteases, has low similarity to cathepsin H (rat Ctsh), which is a lysosomal cysteine (thiol) protease that is involved in a variety of proteolytic processes Y113G7B.16 Y113G7B.16 Protein of unknown function, has moderate similarity to uncharacterized mouse BC002318 Y113G7B.17 Y113G7B.17 Protein with high similarity to heterogeneous nuclear ribonucleoproteins methyltransferase-like 2 (rat Hrmt1l2), which methylates arginine residues and is a transcriptional co-activator Y113G7B.18 Y113G7B.18 Protein of unknown function Y113G7B.2 Y113G7B.2 Protein of unknown function, putative paralog of C. elegans T20B3.5 Y113G7B.21 Y113G7B.21 Protein of unknown function Y113G7B.23 psa-1;Y113G7B.23 Putative component of a SWI/SNF chromatin remodeling complex, active in the control of mitosis SWI/SNF protein; The psa-1 (phasmid socket absent) gene encodes a ortholog of SWI3, a component of the SWI/SNF complex that is conserved from yeast to mammals and that is involved in chromatin remodeling; psa-1 is probably required during mitosis of the T cells for asymmetric cell division. Y113G7B.3 Y113G7B.3 Protein of unknown function, putative paralog of C. elegans Y113G7B.B This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins; this gene's encoded protein also contains an FTH/DUF38 motif, which may also mediate protein-protein interaction. Y113G7B.4 ftr-1;Y113G7B.4 Protein with high similarity to C. elegans FOG-2, which is required for the sexual identity of germ cells, contains a DUF38 domain of unknown function and an F-box domain, which serve as a link between a target protein and a ubiquitin-conjugating enzyme This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins; this gene's encoded protein also contains an FTH/DUF38 motif, which may also mediate protein-protein interaction. Y113G7B.5 fog-2;Y113G7B.C;Y113G7B.5 Protein required for the sexual identity of germ cells The fog-2 gene encodes a novel protein, with an N-terminal F-box and a C-terminal FTH domain, that is required for hermaphrodite spermatogenesis; FOG-2 interacts with the RNA-binding protein GLD-1 and the tra-2 3' untranslated region to translationally repress tra-2 expression in the hermaphrodite germ line and thus allow for a brief period of spermatogenesis. Y113G7B.6 Y113G7B.6 Protein containing a DUF38 domain of unknown function and an F-box domain, which serve as a link between a target protein and a ubiquitin-conjugating enzyme, has moderate similarity to C. elegans FOG-2, which is required for sexual identity of germ cells This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins; this gene's encoded protein also contains an FTH/DUF38 motif, which may also mediate protein-protein interaction. Y113G7B.7 Y113G7B.7 Protein containing a DUF38 domain of unknown function and an F-box domain, which serve as a link between a target protein and a ubiquitin-conjugating enzyme, has moderate similarity to C. elegans FOG-2, which is required for sexual identity of germ cells This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins; this gene's encoded protein also contains an FTH/DUF38 motif, which may also mediate protein-protein interaction. Y113G7B.8 Y113G7B.8 Putative ortholog of C. elegans Y113G7B.F gene product This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins. Y113G7B.9 Y113G7B.9 Putative ortholog of C. elegans C07G3.7 gene product 7TM receptor, srbc family Y113G7B.A Y113G7B.1;Y113G7B.A Protein containing a DUF38 domain of unknown function and an F-box domain, which serve as a link between a target protein and a ubiquitin-conjugating enzyme, has moderate similarity to C. elegans FOG-2, which is required for sexual identity of germ cells Y113G7C.B Y113G7C.1;Y113G7C.B Member of the protein-tyrosine phosphatase family, which are involved in control of cell growth, proliferation, differentiation and transformation, contains a WSN domain of unknown function, has a region of low similarity to C. elegans F10G8.1 Y116A8A.2 Y116A8A.2 Putative ortholog of C. elegans Y116A8A.7 gene product Y116A8A.3 Y116A8A.3 Putative ortholog of C. elegans Y116A8A.1 gene product Y116A8A.4 Y116A8A.4 Putative ortholog of C. elegans Y116A8A.6 gene product Y116A8A.6 Y116A8A.6 Putative ortholog of C. elegans Y116A8A.4 gene product Y116A8A.7 Y116A8A.7 Putative paralog of C. elegans Y116A8A.2 Y116A8A.8 Y116A8A.8 Protein of unknown function, has strong similarity to C. elegans C42D4.11 gene product, member of the C-type lectin family Y116A8A.9 Y116A8A.9 Putative ortholog of C. elegans F53B6.5 gene product Y116A8A.B Y116A8A.1;Y116A8A.B Protein containing a C-type lectin domain, which mediate calcium-dependent carbohydrate recognition, has low similarity to uncharacterized C. elegans Y53H1A.3 Y116A8A.F Y116A8C.20;Y116A8A.F Protein containing two CCCH-type zinc finger domains, which bind DNA or RNA, has a region of high similarity to a region of C. elegans POS-1, which is a protein involved in regulation of early morphogenesis Y116A8A.G Y116A8C.19;Y116A8A.G Protein containing two CCCH-type zinc finger domains, which bind DNA or RNA, has moderate similarity to a region of C. elegans POS-1, which is involved in regulation of early morphogenesis Y116A8A.J Y116A8C.16;Y116A8A.N;Y116A8A.J Member of the rhomboid family of integral membrane proteins, has high similarity to uncharacterized C. elegans Y116A8C.14 Y116A8A.L Y116A8C.15;Y116A8A.L Protein of unknown function, has moderate similarity to C. elegans Y116A8A.N Y116A8B.1 Y116A8B.1 Protein with strong similarity to C. elegans F49B2.3 gene product Y116A8B.2 Y116A8B.2 Member of the transposase family, which are required for excising and inserting mobile genetic elements, has very strong similarity to uncharacterized C. elegans F44F4.8 HYPOTHETICAL 29.3 KD PROTEIN B0280.6 IN CHROMOSOME III Y116A8B.4 Y116A8B.4 Protein of unknown function Y116A8B.5 Y116A8B.5 Member of the rhodopsin family of G-protein coupled receptors (GPCR), has low similarity to somatostatin receptor 2 (human SSTR2), which inhibits adenylyl cyclase and mediates the inhibitory effects of somatostatin 7 transmembrane receptor (rhodopsin family) Y116A8C.1 Y116A8C.1 Protein of unknown function, has strong similarity to uncharacterized C. elegans Y73F8A.Z Y116A8C.10 Y116A8C.10 Protein of unknown function, has a region of low similarity to a region of ras-related GTP-binding protein 28 (human RAB28), which is a GTP-binding protein and GTPase Y116A8C.11 Y116A8C.11 Putative coiled-coil protein, has similarity to C. elegans Y116A8A.H Y116A8C.12 Y116A8C.12 Putative ortholog of H. sapiens ARF6 (ADP-ribosylation factor 6) arf-6 encodes a small GTP-binding protein of the ADP-ribosylation factor (ARF) family that is orthologous to vertebrate ARF6; by homology, ARF-6 is predicted to function as a GTPase that regulates receptor-mediated endocytosis, and in C. elegans, ARF-6 is strongly expressed in the coelomocytes (highly endocytic cells located in the pseudocoelom) where it colocalizes in the cytoplasm and to a lesser degree at the plasma membrane with RME-1, a novel EH domain protein, and the myotubularins MTM-6 and MTM-9; loss of arf-6 activity via RNAi does not result in any obvious abnormalities. Y116A8C.13 Y116A8C.13 Protein containing an SNF2 related N-terminal domain and a helicase conserved C-terminal domain, has a region of moderate similarity to a region of S. cerevisiae Rad54p, which is a DNA-dependent ATPase required for mitotic recombination and DNA repair Y116A8C.14 Y116A8C.14 Putative ortholog of D. melanogaster CG5364 (CG5364 gene product) Y116A8C.17 Y116A8C.17 Protein containing two CCCH-type zinc finger domains, which bind DNA or RNA, has high similarity to a region of C. elegans POS-1, which is a protein involved in regulation of early morphogenesis Y116A8C.18 Y116A8C.18 Protein containing a nuclear hormone receptor C4-type zinc finger domain, which bind DNA and may be involved in regulation of transcription, has a region of low similarity to a region of thyroid hormone receptor beta (human THRB) Y116A8C.22 Y116A8C.22 Putative ortholog of C. elegans Y116A8A.D gene product Y116A8C.23 Y116A8C.23 Protein of unknown function, putative paralog of C. elegans Y116A8A.C Y116A8C.24 Y116A8C.24 Putative ortholog of C. elegans Y116A8C.38 gene product Y116A8C.25 Y116A8C.25 Protein of unknown function Y116A8C.26 Y116A8C.26 Protein of unknown function Y116A8C.28 Y116A8C.28 Protein with strong similarity to D. melanogaster CG11967 (CG11967 gene product) Y116A8C.29 Y116A8C.29 Protein of unknown function Y116A8C.3 Y116A8C.3 Member of the protease protein family Y116A8C.32 SF1;Y116A8C.32 Protein with similarity to SF1 and SF1-like splicing factors from human, Drosophila, Arabidopsis, C. briggsae, S. pombe, and S. cerevisiae Y116A8C.32 encodes an ortholog of splicing factor SF1, which enables 3' splice site recognition by binding U2AF65 and the intron branch site during splicing complex formation; Y116A8C.32 shares several domains with mammalian SF1 proteins (a U2AF65 binding domain, a hnRNP K homology domain, two RNA-binding zinc knuckles, and a proline-rich C-terminal domain), while also sharing a hydrophilic N-terminal domain (enriched for serine, arginine, lysine, and aspartate) with Drosophila but not mammalian SF1; Y116A8C.32's N-terminal domain resembles RS domains in other splicing proteins; Y116A8C.32 is required for embryonic viability, normally rapid growth, and proper body morphology. Y116A8C.33 Y116A8C.33 Protein of unknown function, putative paralog of C. elegans Y51A2B.6 Y116A8C.34 Y116A8C.34 Protein with strong similarity to C. elegans cyp-2 gene product cyp-13 encodes a predicted cyclophilin that can function as a nuclease in vitro; functions to regulate DNA degradation and cell death in a genetic pathway with wah-1, cps-6, crn-1, crn-4, crn-5 and these proteins are believed to form a complex in vivo. Y116A8C.35 Y116A8C.35 Protein of unknown function uaf-2 encodes an essential U2AF35 homolog clustered in an operon with cyp-13 (RRM/cyclophilin); UAF-2's sequence is somewhat atypical for U2AF proteins (it lacks an identifiable N-terminal RNA-binding RS domain, while having an glycine-rich C-terminal region). Y116A8C.36 Y116A8C.36 Protein with weak similarity to human NCF1 tag-11/Y116A8C.36 encodes a homolog of human NCF1, which when mutated leads to chronic granulomatous disease (OMIM:306400). Y116A8C.37 Y116A8C.37 Protein of unknown function, putative paralog of C. elegans C15H7.3 Y116A8C.38 Y116A8C.38 Putative ortholog of C. elegans Y116A8C.24 gene product Y116A8C.4 Y116A8C.4 Putative ortholog of C. elegans F18A12.1 gene product Y116A8C.4 encodes a neprilysin; neprilysins are thermolysin-like zinc metallopeptidases, found on the outer surface of animal cells, that negatively regulate small signalling peptides (e.g., enkephalin, tachykinin, insulin, and natriuretic peptides) by cleaving them; Y116A8C.4 has no clear orthologs in other organisms. Y116A8C.40 Y116A8C.40 Putative ortholog of C. elegans R08C7.7 gene product Y116A8C.41 Y116A8C.41 Putative ortholog of C. elegans T02H6.3 gene product Y116A8C.42 snr-1;Y116A8C.42 Protein with high similarity to small nuclear ribonucleoprotein D3 (human SNRPD3), which is an autoantigen in systemic lupus erythematosus that is involved in snRNP formation and mRNA splicing, member of the Sm family small nuclear ribonuclearprotein SM D3 Y116A8C.43 Y116A8C.43 Protein of unknown function Y116A8C.5 Y116A8C.5 Member of the M13 peptidase family of zinc metalloproteases, has weak similarity to mel transforming oncogene-like 1 (soluble secreted endopeptidase, mouse Mell1), which is a type II membrane bound metalloprotease with a secreted alternative form Y116A8C.5 encodes a neprilysin; neprilysins are thermolysin-like zinc metallopeptidases, found on the outer surface of animal cells, that negatively regulate small signalling peptides (e.g., enkephalin, tachykinin, insulin, and natriuretic peptides) by cleaving them; Y116A8C.5 has no clear orthologs in other organisms. Y116A8C.6 Y116A8C.6 Protein of unknown function Y116A8C.7 Y116A8C.7 Protein of unknown function, has weak similarity to C. elegans Y116A8A.T Y116A8C.8 Y116A8C.8 Protein of unknown function, has weak similarity to C. elegans F46F5.15 Y116A8C.9 Y116A8C.9 Protein of unknown function Y116F11A.1 Y116F11A.1 Protein with strong similarity to C. elegans C11G6.2 helicase Y116F11A.3 Y116F11A.3 Protein of unknown function Y116F11A.4 Y116F11A.4 Protein of unknown function, putative paralog of C. elegans Y51A2A.2 Y116F11A.5 Y116F11A.5 Protein of unknown function, has moderate similarity to C. elegans F16H6.7 Y116F11A.6 Y116F11A.6 Protein of unknown function Y116F11A.FF Y43F8B.H;Y43F8B.6;Y116F11A.FF Protein of unknown function Y116F11A.GG Y43F8B.I;Y43F8B.5;Y116F11A.GG Member of the SCP-like extracellular protein family, has low similarity to uncharacterized C. elegans H10D18.2 Y116F11A.JJ Y43F8B.4;Y43F8B.K;Y116F11A.JJ Possible prolyl hydroxylase; has strong similarity to C-terminal region of C. elegans Y47D3B.10, a prolyl 4-hydroxylase, alpha subunit Y116F11B.1 Y116F11B.1 Protein with strong similarity to C. elegans Y116F11B.B gene product Uncloned locus that affects dauer formation and life span. Y116F11B.10 Y116F11B.10 Putative ortholog of C. elegans Y116F11B.K gene product Y116F11B.12 gly-4;Y116F11B.12 N-acetylgalactosaminyltransferase UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase Y116F11B.13 Y116F11B.13 Putative ortholog of C. elegans Y116F11B.N gene product Y116F11B.14 Y116F11B.14 Putative ortholog of C. elegans Y116F11B.P gene product Y116F11B.5 Y116F11B.5 Putative ortholog of C. elegans F19B2.B gene product 7TM chemoreceptor, srw family Y116F11B.6 Y116F11B.6 Putative ortholog of C. elegans Y116F11B.F gene product Y116F11B.7 Y116F11B.7 Putative ortholog of C. elegans Y60A3.Q gene product Y116F11B.8 Y116F11B.8 Putative ortholog of C. elegans Y116F11B.I gene product Y116F11B.9 Y116F11B.9 Putative ortholog of C. elegans Y116F11B.J gene product Y116F11B.A Y116F11B.2;Y116F11B.A Protein of unknown function, has strong similarity to C. elegans F54D10.9 Y116F11B.C Y116F11B.3;Y116F11B.C Putative paralog of C. elegans F23B2.11 Y116F11B.E Y116F11B.4;Y116F11B.E Protein of unknown function, putative paralog of C. elegans Y116F11.B Y116F11B.L Y116F11B.11;Y116F11B.L Protein of unknown function; putative paralog of C. elegans Y51A2B.6 Y119C1A.1 Y119C1A.1 Protein of unknown function Y119C1B.1 Y119C1B.1 Protein with strong similarity to C. elegans Y119C1B.J gene product Y119C1B.10 Y119C1B.10 Putative ortholog of C. elegans Y119C1B.A gene product Y119C1B.4 Y119C1B.4 Putative ortholog of C. elegans Y119C1B.F gene product Y119C1B.5 Y119C1B.5 Putative ortholog of C. elegans Y119C1B.F gene product Y119C1B.8 Y119C1B.8 Putative ortholog of C. elegans Y119C1B.D gene product Y119C1B.C Y119C1B.9;Y119C1B.C Protein of unknown function, predicted to contain a glycosylphosphatidylinositol (GPI) lipid anchor Y119C1B.E Y119C1B.6;Y119C1B.E Protein of unknown function Y119C1B.H Y119C1B.3;Y119C1B.H Protein with strong similarity to D. melanogaster CG14238 (CG14238 gene product) Y119C1B.I Y119C1B.2;Y119C1B.I Protein of unknown function Y119D3A.4 Y119D3A.4 Putative ortholog of C. elegans Y119D3A.A gene product Y119D3A.5 Y119D3A.5 Putative ortholog of C. elegans B0513.7 gene product transposase Y119D3A.B Y119D3A.3;Y119D3A.B Putative ortholog of C. elegans ZC47.10 gene product Y119D3A.C Y119D3A.2;Y119D3A.C Putative ortholog of C. elegans Y82E9BL.7 gene product Y119D3B.12 Y119D3B.12 Protein with strong similarity to C. elegans Y119D3B.O gene product Y119D3B.15 Y119D3B.15 Putative ortholog of C. elegans ZC47.15 gene product Y119D3B.18 Y119D3B.18 Putative ortholog of C. elegans ZC47.2 gene product This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins; this gene's encoded protein also contains an FTH/DUF38 motif, which may also mediate protein-protein interaction. Y119D3B.19 Y119D3B.1;Y119D3B.19 Putative ortholog of C. elegans ZC47.7 gene product This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins; this gene's encoded protein also contains an FTH/DUF38 motif, which may also mediate protein-protein interaction. Y119D3B.2 Y119D3B.20;Y119D3B.2 Putative ortholog of C. elegans ZC47.2 gene product Y119D3B.21 Y119D3B.21 Protein with moderate similarity to C. elegans Y119D3B.Q gene product Y119D3B.8 Y119D3B.8 Protein with strong similarity to C. elegans F52D2.1 gene product Y119D3B.9 Y119D3B.9 Putative ortholog of C. elegans Y119D3B.13 gene product Y119D3B.C Y119D3B.17;Y119D3B.C Protein with moderate similarity to C. elegans C12D8.1 gene product Y119D3B.D Y119D3B.16;Y119D3B.D Putative mitochondrial large ribosomal subunit protein Y119D3B.F Y119D3B.14;Y119D3B.F Putative ortholog of C. elegans Y119D3B.J gene product Y119D3B.G Y119D3B.13;Y119D3B.G Putative ortholog of C. elegans Y119D3B.9 gene product Y119D3B.I Y119D3B.11;Y119D3B.I Protein of unknown function Y119D3B.P Y119D3B.7;Y119D3B.P Putative ortholog of C. elegans F52D2.8 gene product Y119D3B.R Y119D3B.6;Y119D3B.R Putative ortholog of C. elegans ZC47.15 gene product Y119D3B.S Y119D3B.5;Y119D3B.S Putative ortholog of C. elegans Y119D3B.3 gene product Y119D3B.T Y119D3B.3;Y119D3B.T Putative ortholog of C. elegans Y119D3B.5 gene product Y119D3B.U Y119D3B.4;Y119D3B.U Protein with strong similarity to C. elegans ZC47.15 gene product Y119D3_444.A Y82E9BR.20;Y119D3_444.A Protein of unknown function Y119D3_455.A ace-3;ace-y;Y48B6A.8;Y119D3_455.A Acetylcholine esterase Y11D7A.1 Y11D7A.1 Putative ortholog of C. elegans ZK1320.9 gene product Y11D7A.10 Y11D7A.10 Protein of unknown function Y11D7A.11 Y11D7A.11 Protein containing two collagen triple helix repeats, which are found in some extracellular proteins, and a nematode cuticle collagen N-terminal domain, has low similarity to C. elegans MEC-5, which is a collagen Y11D7A.12 Y11D7A.12 Protein with strong similarity to C. elegans C26E6.2 gene product Y11D7A.13 Y11D7A.13 Protein with moderate similarity to C. elegans C26E6.2 gene product Y11D7A.14 Y11D7A.14 Protein containing a myosin head domain (motor domain), has low similarity to non-muscle myosin heavy chain 9 (human MYH9), which is a motor protein that may provide force for cytokinesis and cell adhesion Myosin head (motor domain) Y11D7A.15 Y11D7A.15 Protein with strong similarity to C. elegans C01G6.2 gene product Y11D7A.2 Y11D7A.2 Protein of unknown function, has moderate similarity to C. elegans ZK1320.9 Y11D7A.3 Y11D7A.3 Member of an uncharacterized protein family Y11D7A.4 Y11D7A.4 Protein with high similarity to Ras-related GTP-binding protein 28 (human RAB28), which is a GTP-binding protein and GTPase, member of the Ras superfamily of GTP-binding proteins Ras family; rab-28 encodes a small GTPase homologous to the Rab GTPases that function in endocytosis, membrane fusion, and vesicular trafficking events; the precise biological role and expression pattern of rab-28 are not yet known. Y11D7A.5 Y11D7A.5 Protein of unknown function Y11D7A.6 Y11D7A.6 Member of the reverse transcriptase protein family reverse transcriptase Y11D7A.7 Y11D7A.7 Protein of unknown function Y11D7A.8 Y11D7A.8 Protein containing a DUF 227 domain of unknown function Y11D7A.9 Y11D7A.9 Protein of unknown function, has low similarity to uncharacterized C. elegans T23B12.5 Y12A6A.1 Y12A6A.1 Protein of unknown function, has weak similarity to C. elegans F15B9.5; may be anchored to the membrane of a secretory vesicle or the Golgi apparatus Y12A6A.2 Y12A6A.2 Protein of unknown function Y13C8A.1 Y13C8A.1 Protein of unknown function, has strong similarity to C. elegans F29G9.1 Y14H12A.1 Y14H12A.1 Putative ortholog of C. elegans Y14H12A_90.B gene product Y14H12B.1 Y14H12B.1 Protein of unknown function, has similarity to zinc finger domain zinc-finger protein Y14H12B.2 Y14H12B_90.A;Y14H12B.2 Protein of unknown function, has moderate similarity to uncharacterized C. elegans C16A11.4 Y15E3A.1 Y15E3A.1 Putative paralog of C. elegans Y15E3.A nuclear hormone receptor nhr-91; nhr-91 encodes a conserved nuclear receptor that is orthologous to members of the NR6 subfamily of nuclear receptors that includes Drosophila HR4 and human germ cell nuclear factor (GCNF, OMIM:600281, human and mouse GCNF are expressed primarily in the testis); by homology, NHR-91 is predicted to function as a transcription factor that may activate or repress transcription in response to a hormonal signal; however, as loss of nhr-91 activity via RNAi does not result in any obvious abnormalities, the precise role of NHR-91 in C. elegans development and/or behavior is not yet known; nhr-91 is expressed in anterior neurons, seam cells, excretory cells, the spermatheca, and the developing vulva. Y15E3A.2 Y15E3.B;Y15E3B.C;Y15E3A.2 Protein of unknown function, has weak similarity to C. elegans C26C6.7 Y15E3A.3 Y15E3A.3 Protein of unknown function, putative paralog of C. elegans Y15E3.C Y16B4A.1 unc-3;olf-1;Y16B4A.1 Transcription factor of the Olf-1/EBF family that is required for normal ventral motor neuron axonal outgrowth and guidance and normal ASI amphid neuron chemosensation transcription factor OLF-1 like; The unc-3 gene encodes a protein with homology to immunoglobulin (Ig) domain-containing transcription factors such as OLF-1 or SU(H). Y16B4A.2 Y16B4A.2 Serine carboxypeptidase serine carboxypeptidase Y16E11A.1 Y16E11A.1 Putative paralog of C. elegans ZK250.6 Y16E11A.2 ZK250.9;Y16E11A.2 Putative paralog of C. elegans F59H6.I, has similarity at the C-terminus of S. cerevisiae PIF1, mitochondrial DNA repair and recombination protein Y17D7A.1 Y17D7A.1 Protein containing two nuclear hormone receptor C4-type zinc finger domains, which bind DNA and may be involved in regulation of transcription, has moderate similarity to a region of C. elegans NHR-58, which is involved in embryogenesis and morphogenesis Zinc finger, C4 type (two domains) Y17D7A.2 Y17D7A.2 Protein containing a nuclear hormone receptor ligand-binding domain, has moderate similarity to a region of C. elegans NHR-58, which is a putative ligand-dependent nuclear receptor that plays a role in embryogenesis and morphogenesis Domain of unknown function Y17D7A.3 nhr-65;Y17D7A.3 Member of the nuclear hormone receptor/Zinc finger protein family Zinc finger, C4 type (two domains) Y17D7A.4 Y17D7A.4 Member of the cytochrome P450 family, has low similarity to cytochrome P450 2j4 (rat Cyp2j4), which is a monooxygenase that converts arachidonic acid to hydroxyeicosatetraenoic and epoxyeicosatrienoic acids Cytochrome P450 Y17D7B.1 Y17D7B.1 Protein containing a nuclear hormone receptor C4-type zinc finger domain, which bind DNA and may be involved in regulation of transcription, has weak similarity to C. elegans NHR-58, which is involved in embryogenesis and morphogenesis Zinc finger, C4 type (two domains) Y17D7B.2 Y17D7B.2 Protein of unknown function, has low similarity to uncharacterized C. elegans F17C11.11 Y17D7B.3 Y17D7B.3 Protein of unknown function, has weak similarity to C. elegans C06B3.7 Y17D7B.4 Y17D7B.4 Protein of unknown function Y17D7B.5 Y17D7B.5 Protein with similarity to members of the C-type lectin family Y17D7B.6 Y17D7B.6 Member of the C-type lectin family Lectin C-type domain Y17D7B.7 Y17D7B.7 Protein of unknown function Y17D7C.1 Y17D7C.1 Protein of unknown function Y17D7C.2 Y17D7C.2 Protein of unknown function, has strong similarity to C. elegans Y69H2.L Y17G7A.1 hmg-12;hmg-I-beta;Y17G7A.1 Protein containing seven AT-hook motifs, which bind DNA with a preference for A-T rich regions Y17G7B.1 Y17G7B.1 Protein containing an acyl CoA binding domain, has moderate similarity to uncharacterized mouse Dbi Acyl CoA binding protein Y17G7B.10 Y17G7B.10 Protein containing an uncharacterized domain DUF15, has moderate similarity to uncharacterized C. elegans Y77E11A.2 Y17G7B.11 Y17G7B.11 Protein with weak similarity to vitamin D-3 upregulated protein-1 (mouse Txnip), which is a thioredoxin binding protein induced by oxidative stress that functions as an oxidative stress mediator by inhibiting thioredoxin activity Y17G7B.12 Y17G7B.12 Member of the exonuclease family, has a region of moderate similarity to interferon-stimulated gene 20 kDa (human ISG20), which is an estrogen- and interferon-induced (human IFN) exonuclease with preference for RNA over single-stranded DNA Exonuclease Y17G7B.13 Y17G7B.13 Protein of unknown function Y17G7B.14 Y17G7B.14 Protein with weak similarity to vitamin D-3 upregulated protein-1 (mouse Txnip), which is a thioredoxin binding protein induced by oxidative stress that functions as an oxidative stress mediator by inhibiting thioredoxin activity Y17G7B.15 cnt-1A;Y17G7B.15 Protein containing 3 ankyrin repeats, 2 pleckstrin homology domains, and 2 putative arf GTPase activation domains, has a region of low similarity to a region of development and differentiation enhancing factor 2 (human DDEF2), which activates ARF GTPase PH (pleckstrin homology) domain, Ank repeat (2 domains); cnt-1 encodes a homolog of centaurin beta, an Arf GTPase activating protein (Arf GAP) that also contains a pleckstrin homology domain and C-terminal ankyrin repeats; by homology, CNT-1 is predicted to function as an Arf GAP that stimulates Arf GTPase activity and links cell signaling with cytoskeletal rearrangements and membrane trafficking; however, as loss of cnt-1 activity via large-scale RNAi screens does not result in any obvious abnormalities, the precise role of cnt-1 in C. elegans development and/or behavior is not yet known; cnt-1 is broadly expressed, being detected in the pharynx, excretory cell, spermatheca, distal tip cells of the gonad, neurons of the head and nerve ring, and anal epithelial cells; CNT-1 is able to bind the phosphoinositides PIP2 and PIP3 and upon production of PIP3, can translocate from the cytoplasm to the membrane. Y17G7B.17 Y17G7B.17 Protein with similarity to human myelodysplasia/myeloid leukemia factor 2 (MLF2) (Hs.79026) Y17G7B.18 Y17G7B.18 Protein of unknown function, has very strong similarity to uncharacterized C. elegans Y17G7B.18A Y17G7B.19 Y17G7B.19 Protein of unknown function, has weak similarity to C. elegans F09E8.1 Y17G7B.2 Y17G7B.2 Protein containing three SPRY (SPla and RYanodine Receptor) domains, has moderate similarity to uncharacterized ash2 like (human ASH2L) Y17G7B.3 Y17G7B.3 Protein with high similarity to hydroxyacyl glutathione hydrolase (glyoxalase II, human HAGH), which is involved in the detoxification of methylglyoxal and other alpha oxoaldehydes, member of the metallo-beta-lactamase family Metallo-beta-lactamase superfamily; Y17G7B.3 is orthologous to the human gene HYDROXYACYLGLUTATHIONE HYDROLASE (HAGH; OMIM:138760), which when mutated leads to disease. Y17G7B.4 Y17G7B.4 Protein with high similarity to deoxyhypusine synthase (S. cerevisiae Dys1p), which converts lysine and spermidine into deoxyhypusine during hypusine biosynthesis, member of the deoxyhypusine synthase family, which are involved in cell proliferation Y17G7B.5 Y17G7B.5 Protein with high similarity to mini chromosome maintenance deficient 2 (mouse Mcmd2), which is a chromatin-binding protein that binds histone H3 and is involved in regulation of DNA replication, member of the MCM family of DNA-dependent ATPases MCM2/3/5 family Y17G7B.6 Y17G7B.6 Protein of unknown function, has low similarity to uncharacterized C. elegans W01C9.5 Globin Y17G7B.7 tpi-1;Y17G7B.7;TPI Protein with high similarity to triosephosphate isomerase 1 (human TPI1), which catalyzes a step in glycolysis and is associated with hemolytic anemia, neurodegeneration and antigenicity of melanoma cells, member of the triosephosphate isomerase family Triosephosphate isomerase; tpi-1 is orthologous to the human gene TRIOSEPHOSPHATE ISOMERASE 1 (TPI1; OMIM:190450), which when mutated leads to disease. Y17G7B.8 Y17G7B.8 Protein containing an F-box domain, which serve as a link between a target protein and a ubiquitin-conjugating enzyme, has low similarity to uncharacterized C. elegans F16B4.2 Y17G7B.9 cyp-16;Y17G7B.9 Protein with high similarity to C. elegans CYP-10, which is a cyclophilin-related peptidylprolyl cis-trans-isomerase, member of the cyclophilin type peptidyl-prolyl cis-trans isomerase family Peptidyl-prolyl cis-trans isomerases Y17G9A.1 Y17G9A.1 Protein of unknown function, putative paralog of C. elegans Y17G9A_2.D 7TM chemoreceptor, str family Y17G9A.2 Y17G9A_2.G;Y17G9A.G;Y17G9A.2 Protein of unknown function, has moderate similarity to uncharacterized C. elegans Y17G9A.3 Y17G9A.3 Y17G9A.3 Protein of unknown function, putative paralog of C. elegans Y17G9A.4 Y17G9A.4 Y17G9A.4 Protein of unknown function, putative paralog of C. elegans Y17G9A.3 Y17G9A.5 Y17G9A.5 Protein of unknown function, putative paralog of C. elegans Y17G9A.6 7TM chemoreceptor, str family Y17G9A.6 Y17G9A.6 Protein of unknown function, putative paralog of C. elegans Y17G9A.5 7TM chemoreceptor, str family Y17G9B.1 Y17G9B.1 Protein with strong similarity to C. elegans Y75B8A.25 gene product Y17G9B.2 Y17G9B.2 Protein of unknown function, has weak similarity to C. elegans E04A4.1 Y17G9B.3 Y17G9B.3 Putative ortholog of D. melanogaster CG3540 (CG3540 gene product) cytochrome P450; The Y17G9B.3 gene encodes a homolog of the human gene CYP7B1, which when mutated leads to pseudovitamin D deficiency rickets (OMIM:264700). Y17G9B.4 Y17G9B.4 Protein with moderate similarity to C. elegans cyp-2 (Cyclophilin-related peptidylprolyl cis-trans-isomerase) isomerase Y17G9B.5 Y17G9B.5 Protein with moderate similarity to D. melanogaster ECSIT (Protein of unknown function) Y17G9B.6 Y17G9B.6 Protein of unknown function Y17G9B.7 Y17G9B.7 Protein of unknown function, has strong similarity to C. elegans E04A4.1 Y17G9B.8 Y17G9B.8 Protein with moderate similarity to D. melanogaster CG10509 (CG10509 gene product) Y17G9B.9 Y17G9B.9 Protein of unknown function, putative paralog of C. elegans H02I12.5 Y18D10A.11 Y18D10A.K;Y18D10A.11 Putative coiled-coil protein, has weak similarity to myosins Y18D10A.13 pad-1;DopA;Y18D10A.N;Y18D10A.13 Protein with strong similarity to S. cerevisiae Dop1p The pad-1 gene encodes a highly conserved, but unfamiliar, protein that is required for embryonic development. Y18D10A.16 Y18D10A.O;Y18D10A.16 Protein with similarity to S. cerevisiae Pet191p, involved in assembly of cytochrome oxidase Y18D10A.18 Y18D10A.18 Putative ortholog of C. elegans Y18D10A.Q gene product This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins; this gene's encoded protein also contains an FTH/DUF38 motif, which may also mediate protein-protein interaction. Y18D10A.19 FKBP-2;FKBP-12;Y18D10A.19 Similar to FKBP-type peptidyl-prolyl cis-trans isomerases FKBP-type peptidyl-prolyl cis-trans isomerases; fkb-2 encodes a peptidylprolyl cis/trans isomerase homologous to the mammalian FK506 immunosuppressant-binding protein 1A (FKBP1A, OMIM:186945, mutations associated with myocardial noncompaction); by homology, FKB-2 could function in a number of processes including protein folding, signal transduction, and regulation of muscle contraction; however, the precise role of FKB-2 in C. elegans development and/or behavior is not yet known,. Y18D10A.23 Y18D10A.M;Y18D10A.23 Member of an uncharacterized protein family Y18D10A.4 Y18D10A.E;Y18D10A.4 Protein of unknown function Y18D10A.5 gsk-3;sgg-1;Y18D10A.F;Y18D10A.5 Serine/threonine protein kinase; strongly similar to human GSK3B, glycogen synthase 3 beta; required for proper spindle orientation and polarization of the EMS blastomere Eukaryotic protein kinase domain Y18D10A.7 ptr-17;Y18D10A.7 Protein of unknown function with weak similarity to H. sapiens NPC1 Y18D10A.B Y18D10A.1;Y18D10A.B Protein of unknown function, has moderate similarity to H. sapiens Hs.169504 gene product Y18D10A.C Y18D10A.2;Y18D10A.C Protein of unknown function, has low similarity to uncharacterized C. elegans ZK669.2 Y18D10A.D Y18D10A.3;Y18D10A.D Protein of unknown function, has a region of moderate similarity to S. cerevisiae Ynl200p Y18D10A.G Y18D10A.6;Y18D10A.G Member of the sodium or hydrogen exchanger family, which maintain the pH of actively metabolizing cells, has a region of moderate similarity to a region of S. cerevisiae Nhx1p, which is a Na+/H+ antiporter required for endosomal protein trafficking Y18D10A.H Y18D10A.8;Y18D10A.H Protein containing a KH domain, which may bind RNA Y18D10A.I Y18D10A.9;Y18D10A.I Protein containing six WD domains (WD-40 repeat), which may mediate protein-protein interactions, has moderate similarity to WD40 protein Ciao1 (human CIAO1), which is a putative transcription cofactor Y18D10A.J Y18D10A.10;Y18D10A.J Protein containing a C-type lectin domain, which mediate calcium-dependent carbohydrate recognition, has high similarity to uncharacterized C. elegans Y18D10A.12 Y18D10A.L Y18D10A.12;Y18D10A.L Protein containing a C-type lectin domain, which mediate calcium-dependent carbohydrate recognition, has high similarity to uncharacterized C. elegans Y18D10A.10 Y18D10A.P Y18D10A.17;Y18D10A.P Protein of unknown function, has low similarity to uncharacterized S. cerevisiae Scd6p Y18D10A.T pfn-1;Y18D10A.20;Y18D10A.T Member of the profilin protein family Y18D10A.U Y18D10A.21;Y18D10A.U Protein with moderate similarity to C. elegans F46A9.1 gene product Y18H1A.1 Y18H1A.1 Putative ortholog of C. elegans C24D10.1 gene product Y18H1A.10 Y18H1A.10 Protein with strong similarity to C. elegans C01H6.9 gene product Y18H1A.2 Y18H1A.2 Protein of unknown function Y18H1A.3 Y18H1A.3 Protein with weak similarity to C. elegans F47F6.7 gene product Y18H1A.4 Y18H1A.4 Protein with strong similarity to C. elegans ZK484.6 gene product Y18H1A.6 Y18H1A.6 Putative ortholog of C. elegans cePIF1 gene product Y18H1A.7 Y18H1A.7 Protein with weak similarity to C. elegans F36F12.4 gene product Y18H1A.8 Y18H1A.8 Protein with strong similarity to C. elegans K04F1.9 gene product Y18H1A.9 Y18H1A.9 Putative ortholog of C. elegans R11A5.7 gene product Y19D10A.7 Y19D10A.7 Putative ortholog of C. elegans F56A4.9 gene product Y19D10A.8 Y19D10A.8 Putative ortholog of C. elegans F56A4.11 gene product Y19D10A.9 Y19D10A.9 Putative ortholog of C. elegans F15E11.9 gene product Y19D10A.A Y19D10A.14;Y19D10A.A Protein with strong similarity to C. elegans C01B4.A gene product Y19D10A.E Y19D10A.12;Y19D10A.E Protein with a region of low similarity to a region of monocarboxylate cotransporter 2, (rat Slc16a7), which mediates the transport of lactate and pyruvate across plasma membranes Y19D10A.F Y19D10A.11;Y19D10A.F Protein with similarity to human and D. melanogaster sodium-dependent inorganic phosphate cotransporters Y19D10A.G Y19D10A.10;Y19D10A.G Protein with similarity to human and D. melanogaster sodium-dependent inorganic phosphate cotransporters Y19D10A.K Y19D10A.6;Y19D10A.K Member of the astacin (M12A) family of metalloproteases, has very strong similarity to uncharacterized C. elegans F56A4.1 Y19D10A.M Y19D10A.5;Y19D10A.M Protein with low similarity to solute carrier family 17 member 1 (mouse SLC17A1), which is involved in sodium-dependent phosphate transport, mediates hepatic and renal anion drug transport and plays a role in maintaining phosphate homeostasis Y19D10A.N Y19D10A.4;Y19D10A.N Member of the aldose 1-epimerase family, which interconvert aldoses between their alpha- and beta-forms, has a region of low similarity to a region of S. cerevisiae Gal10p, which is an UDP-glucose 4-epimerase that catalyzes a step in galactose metabolism Y19D10A.O Y19D10A.3;Y19D10A.O Protein of unknown function, has high similarity to uncharacterized C. elegans C01B4.5 Y19D10A.P Y19D10A.2;Y19D10A.P Member of the 7-transmembrane chemoreceptor family of G-protein coupled receptors (GPCR), has low similarity to C. elegans ODR-10, which is a G protein-coupled receptor involved in odorant response Y19D10A.Q Y19D10A.1;Y19D10A.Q Putative ortholog of C. elegans C01B4.K gene product Y19D10B.A Y19D10B.7;Y19D10B.A Putative ortholog of C. elegans F15E11.13 gene product Y19D10B.B Y19D10B.6;Y19D10B.B Protein of unknown function, putative paralog of C. elegans T28A11.17 Y19D10B.D Y19D10B.4;Y19D10B.D Putative ortholog of C. elegans C05D12.2 gene product Y19D10B.E Y19D10B.3;Y19D10B.E Protein with strong similarity to C. elegans Y19D10B.2 gene product Y19D10B.F Y19D10B.2;Y19D10B.F Protein of unknown function, putative paralog of C. elegans F11A5.7 Y19D2B.1 Y19D2B.1 Member of the tubulin-FtzA family, which are involved in polymer formation, has strong similarity to a region of alpha tubulin (C. elegans TBA-2), which is involved in embryogenesis and morphogenesis Y1A5A.1 Y1A5A.1 Protein containing 2 LIM domains, which may mediate protein-protein interactions, has low similarity to a region of Z-band alternatively spliced PDZ-motif protein (human LDB3), which has a Z-band component and may act as a cytoskeletal adaptor protein LIM domain containing proteins (2 domains) Y1A5A.2 Y1A5A.2 Protein of unknown function Y1B5A.1 Y1B5A.1 Protein of unknown function Y20C6A.1 Y20C6A.1 Protein containing three DUF38 domains of unknown function and an F-box domain, which serve as a link between a target protein and a ubiquitin-conjugating enzyme, has strong similarity to uncharacterized C. elegans Y6G8.2 This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins; this gene's encoded protein also contains an FTH/DUF38 motif, which may also mediate protein-protein interaction. Y20C6A.2 Y20C6A.2 Protein of unknown function, has weak similarity to uncharacterized C. elegans R08C7.9 Y20C6A.3 Y20C6A.3 Putative ortholog of C. elegans Y67D8C.2 gene product Y20F4.2 Y20F4.2 Protein of unknown function Y20F4.3 Y20F4.3 Protein of unknown function Y20F4.4 Y20F4.4 Putative ortholog of C. elegans F09E5.10 gene product Y20F4.5 Y20F4.5 Putative ortholog of C. elegans K08D10.1 gene product Y20F4.7 Y20F4.7 Protein of unknown function Y22D7AL.4 Y22D7AL.4 Protein with strong similarity to C. elegans Y22D7AL.T gene product Y22D7AL.5 hsp-60;HSP60;CPN60;Y22D7AL.5 Protein with high similarity to chaperonin 60 (mouse Hsp60), which is a component of the chaperonin complex that is implicated in mitochondrial protein folding and function, member of the tailless complex polypeptide (TCP-1) or chaperonin (cpn60) family hsp-60 encodes a mitochondrial-specific chaperone that is a member of the GroE/Hsp10/60 superfamily of molecular chaperones; hsp-60 is believed to be involved in the mitochondrial unfolded protein response, as hsp-60 expression, normally broadly detected during development, is greatly increased in response to treatments that disrupt mitochondrial protein handling; loss of hsp-60 activity via RNAi results in severe growth defects with arrest at embryonic and early larval stages of development. Y22D7AL.A Y22D7AL.16;Y22D7AL.A Protein with weak similarity to C. elegans T20H4.2 gene product Y22D7AL.B Y22D7AL.15;Y22D7AL.B Protein with strong similarity to C. elegans Y41C4A.11 gene product Y22D7AL.C Y22D7AL.14;Y22D7AL.C Protein with moderate similarity to C. elegans cht-1 gene product Y22D7AL.E Y22D7AL.13;Y22D7AL.E Protein of unknown function Y22D7AL.F Y22D7AL.12;Y22D7AL.F Protein of unknown function Y22D7AL.G Y22D7AL.11;Y22D7AL.G Protein with strong similarity to C. elegans W02B3.4 gene product Y22D7AL.K Y22D7AL.10;Y22D7AL.J;Y22D7AL.K Protein of unknown function Y22D7AL.M Y22D7AL.9;Y22D7AL.M Protein of unknown function Y22D7AL.N Y22D7AL.8;Y22D7AL.N Protein with strong similarity to C. elegans F53H8.4 gene product Y22D7AL.O Y22D7AL.7;Y22D7AL.O Protein of unknown function Y22D7AL.P Y22D7AL.6;Y22D7AL.P Protein of unknown function Y22D7AL.U Y22D7AL.3;Y22D7AL.U Protein of unknown function Y22D7AL.V Y22D7AL.2;Y22D7AL.V Protein with moderate similarity to C. elegans F11D11.10 gene product Y22D7AL.W Y22D7AL.1;Y22D7AL.W Protein of unknown function Y22D7AR.10 Y22D7AR.10 Protein of unknown function Y22D7AR.12 Y22D7AR.12 Putative ortholog of C. elegans R06B10.1 gene product Y22D7AR.13 Y22D7AR.13 Putative ortholog of C. elegans 5HT3-Ce gene product Y22D7AR.D Y22D7AR.11;Y22D7AR.D Putative ortholog of C. elegans T12B5.11 gene product Y22D7AR.E Y22D7AR.9;Y22D7AR.E Protein with strong similarity to C. elegans ZC47.4 gene product Y22D7AR.F Y22D7AR.8;Y22D7AR.F Putative ortholog of C. elegans C39B5.12 gene product Y22D7AR.G Y22D7AR.7;Y22D7AR.G Putative ortholog of C. elegans Y22D7AR.12 gene product Y22D7AR.H Y22D7AR.6;Y22D7AR.H Protein with strong similarity to C. elegans F30A10.3 gene product Y22D7AR.I Y22D7AR.5;Y22D7AR.I Protein with moderate similarity to C. elegans C23H5.2 gene product Y22D7AR.J Y22D7AR.4;Y22D7AR.J Protein of unknown function Y22D7AR.K Y22D7AR.3;Y22D7AR.K Protein of unknown function Y22D7AR.L Y22D7AR.2;Y22D7AR.L Putative ortholog of C. elegans R155.2 gene product Y22D7AR.M Y22D7AR.1;Y22D7AR.M Protein with strong similarity to C. elegans R155.2 gene product Y22F5A.1 Y22F5A.1 Member of the nuclear hormone receptor/Zinc finger protein family Zinc finger, C4 type (two domains) Y22F5A.2 Y22F5A.2 Member of the 7-transmembrane chemoreceptor family of G-protein coupled receptors (GPCR), has low similarity to uncharacterized C. elegans F39E9.3 7TM chemoreceptor, sri family Y22F5A.3 Y22F5A.3 Protein with high similarity to synaptosomal-associated protein 25 kDa (rat Snap25), which is a t-SNARE that plays a role in membrane fusion duringexocytosis and neurotransmitter release, member of the synaptosome-associated protein 25 kD(SNAP-25)family SNAP-25 family Y22F5A.4 Y22F5A.4 Member of an uncharacterized protein family with weak similarity to Entemeba histolytica N-acetylmuraminidase Y22F5A.5 Y22F5A.5 Member of an uncharacterized protein family with weak similarity to Entemeba histolytica N-acetylmuraminidase lys-2 is one of ten C. elegans lysozyme genes; as such, lys-2 can be predicted to have a role in lysozymal function including immune function. Y22F5A.6 Y22F5A.6 Member of an uncharacterized protein family with weak similarity to Entemeba histolytica N-acetylmuraminidase lys-3 encodes one of a family of ten C. elegans lysozyme genes that are homologous to lysozymes in the amoeboid protozoon Entamoeba histolytica. Y23B4A.1 Y23B4A.1 Protein of unknown function Y23B4A.2 Y23B4A.2 Protein of unknown function Y23H5A.1 Y23H5A.1 Member of the class I cysteinyl (C) tRNA synthetase family, has a region of high similarity to a region of cysteinyl-tRNA synthetase (human CARS), which aminoacylates cognate tRNA with cysteine for protein biosynthesis aminoacyl-tRNA synthetase; crs-2 encodes a predicted cysteinyl-tRNA synthetase required for fertility. Y23H5A.2 Y23H5A.2 Protein of unknown function Y23H5A.3 Y23H5A.3 Protein of unknown function Y23H5A.4 Y23H5A.4 Protein containing a major sperm protein (MSP) domain, which is involved in sperm motility, has high similarity to uncharacterized C. elegans Y48B6A.5 Y23H5A.5 Y23H5A.5 Member of the vinculin family of cytoskeletal proteins, which mediate the binding of actin-based microfilaments to plasma membranes, has weak similarity to alpha-catenin (C. elegans HMP-1), which is a cell junction protein required normal body development ctn-1 encodes a protein that belongs to the alpha-catulin family of catenin-like proteins; the precise function of ctn-1 is not yet known; the CTN-1 promoter-GFP fusion protein is expressed in body wall, vulval and anal muscle tissues. Y23H5A.7 Y23H5A.7 Protein with high similarity to cysteinyl-tRNA synthetase (human CARS), which aminoacylates tRNA with cysteine for protein biosynthesis and interacts with elongation factor 1 gamma (human EEF1G), member of the class I cysteinyl (C) tRNA synthetase family aminoacyl-tRNA synthetase; crs-1 encodes a predicted cytoplasmic cysteinyl-tRNA synthetase (CysRS), a class I aminoacyl-tRNA synthetase that catalyzes the attachment of cysteine to its cognate tRNA and is thus required for protein biosynthesis; CRS-1 is essential for embryonic and larval development, and is required for molting and a normal rate of postembryonic development. Y23H5A.8 Y23H5A.8 Protein with strong similarity to C. elegans C49G7.9 gene product Y23H5B.7 Y23H5B.7 Protein with strong similarity to C. elegans Y39A1A.16 gene product Y23H5B.A Y23H5B.9;Y23H5B.A Protein of unknown function, has moderate similarity to C. elegans C24D10.8 Y23H5B.B Y23H5B.8;Y23H5B.B Protein with weak similarity to C. elegans Y23H5B.1 gene product Y23H5B.C Y23H5B.6;Y23H5B.C Putative ortholog of S. cerevisiae HCA4 gene product (Probable RNA helicase CA4, involved in ribosomal RNA processing) Y23H5B.D Y23H5B.5;Y23H5B.D Protein with moderate similarity to D. melanogaster EG:25E8.3 (Protein of unknown function) Y23H5B.E Y23H5B.4;Y23H5B.E Protein with moderate similarity to D. melanogaster CG13229 (CG13229 gene product) Y23H5B.F Y23H5B.3;Y23H5B.F Protein of unknown function, has weak similarity to C. elegans D1086.1 Y23H5B.G Y23H5B.2;Y23H5B.G Protein of unknown function, has moderate similarity to C. elegans K06A4.1 Y23H5B.H Y23H5B.1;Y23H5B.H Protein of unknown function, has moderate similarity to C. elegans C55C2.3 Y24D9A.2 Y24D9A.2 Putative ortholog of C. elegans Y24D9A_29.G gene product Y24D9A.3 Y24D9A.3 Putative transaldolase, which catalyzes a step in the pentose phosphate pathway Y24D9A.4 Y24D9A.4 Protein with strong similarity to C. elegans rpl-7a gene product rpl-8 encodes a large ribosomal subunit L7a protein required in mass RNAi assays for fertility, vulval development, and general health; the rpl-8 transcription unit has one nonsense transcript that is up-regulated in vivo by smg[-] mutations, indicating that rpl-8 is a natural substrate for SMG-mediated nonsense suppresssion; several other natural mRNA substrates of SMG suppression (e.g., rpl-3, rpl-10, rpl-12) have protein products that are involved in translation. Y24D9A.8 Y24D9A.8 Putative ortholog of C. elegans Y24D9A_29.F gene product Y24D9A.8 is orthologous to the human gene TRANSALDOLASE 1 (TALDO1; OMIM:602063), which when mutated leads to disease. Y24D9A.D rpl-7a;Y24D9A_29.D;Y24D9A.D Protein with high similarity to ribosomal protein L8 (S. cerevisiae Rpl8bp), which is involved in M1 dsRNA virus maintenance, member of the ribosomal L7Ae, L30e, S12e or Gadd45 family, which include ribosomal as well as growth control proteins Y24D9A_29.A Y24D9A.7;Y24D9A_29.A Protein of unknown function Y24D9A_29.B Y24D9A.6;Y24D9A_29.B Protein of unknown function Y24D9A_29.C Y24D9A.5;Y24D9A_29.C Protein of unknown function Y24D9A_29.I Y24D9A.1;Y24D9A_29.I Protein with weak similarity to H. sapiens Hs.5881 (Human ELL mRNA, complete cds) Y24D9B.1 Y24D9B.A;Y24D9B.1 Putative ortholog of C. elegans Y51H4A.K gene product Y24F12A.1 Y24F12A.1 Putative paralog of C. elegans Y37H2A.1 Y24F12A.2 Y24F12A.2 Protein with strong similarity to S. cerevisiae GTR2 (Putative small GTPase, has similarity to Gtr1p) Y24F12A.3 Y24F12A.3 Protein of unknown function, putative paralog of C. elegans Y24F12A.4 Y24F12A.4 Y24F12A.4 Protein of unknown function, putative paralog of C. elegans Y24F12A.3 Y25C1A.11 Y25C1A.11 Protein of unknown function, similar to SRG chemoreceptors 7TM chemoreceptor, srg family Y25C1A.12 Y25C1A.12 Protein of unknown function, similar to SRG chemoreceptors 7TM chemoreceptor, srg family Y25C1A.2 Y25C1A.N;Y25C1A.2 Protein containing a DUF130 domain of unknown function, has moderate similarity to uncharacterized C. elegans R03H10.5 Y25C1A.7 Y25C1A.7 Protein of unknown function Y25C1A.A Y25C1A.13;Y25C1A.A Member of the enoyl-CoA hydratase or isomerase family, has low similarity to short chain enoyl-Coenzyme A hydratase 1 (rat Echs1), which catalyzes the hydration of trans-2-enoyl-CoA forming 3-hydroxyacyl-CoA in mitochondrial fatty acid beta-oxidation Y25C1A.D Y25C1A.10;Y25C1A.D Member of the C.elegans Srg family of integral membrane proteins, which may be involved in chemosensation, has high similarity to uncharacterized C. elegans Y25C1A.11 Y25C1A.F Y25C1A.9;Y25C1A.F Member of the C.elegans Srg family of integral membrane proteins, which may be involved in chemosensation, has high similarity to uncharacterized C. elegans Y25C1A.11 Y25C1A.H Y25C1A.8;Y25C1A.H Member of the zinc finger in Ran binding proteins family, which may be involved in nuclear transport, has moderate similarity to zinc finger protein 265 (human ZNF265), which plays role in mRNA splicing Y25C1A.I Y25C1A.6;Y25C1A.I Protein of unknown function, putative paralog of C. elegans B0454.1 Y25C1A.J Y25C1A.5;Y25C1A.J Protein with high similarity to coatomer protein beta (rat Copb1), which is a component of non-clathrin-coated vesicles essential for membrane trafficking, contains a clathrin-associated adaptin N-terminal domain, which are components of coated vesicles Y25C1A.K Y25C1A.4;Y25C1A.K Protein containing a C-type lectin domain, which mediate calcium-dependent carbohydrate recognition, has high similarity to uncharacterized C. elegans W10G11.6 Y25C1A.L Y25C1A.3;Y25C1A.L Protein containing a C-type lectin domain, has a region of moderate similarity to a region of trophinin (human TRO), which is an adhesion molecule that forms a complex with tastin (human TROAP) and bystin (human BYSL) in the embryonic implantation process Y25C1A.O Y25C1A.1;Y25C1A.O Protein containing a C-type lectin domain, which mediate calcium-dependent carbohydrate recognition, has high similarity to uncharacterized C. elegans R08C7.6 Y26D4A.10 Y26D4A.10 Putative ortholog of C. elegans T20F10.4 gene product Y26D4A.11 Y26D4A.11 Putative paralog of C. elegans Y40C7B.2 Y26D4A.2 Y26D4A.B;Y26D4A.2 Putative ortholog of C. elegans F26F2.6 gene product Y26D4A.5 Y26D4A.E;Y26D4A.5 Protein of unknown function Y26D4A.9 Y26D4A.9 Putative ortholog of C. elegans Y106G6G.5 gene product Y26D4A.C Y26D4A.4;Y26D4A.C Protein containing a C-type lectin domain, which mediate calcium-dependent carbohydrate recognition Y26D4A.D Y26D4A.3;Y26D4A.D Protein containing a C-type lectin domain, which mediate calcium-dependent carbohydrate recognition Y26D4A.F Y26D4A.6;Y26D4A.F Protein containing a C-type lectin domain, which mediate calcium-dependent carbohydrate recognition, has high similarity to uncharacterized C. elegans Y53H1A.3 Y26D4A.G Y26D4A.8;Y26D4A.G Protein of unknown function, has moderate similarity to uncharacterized C. elegans C17H1.7 Y26E6A.1 Y26E6A.1 Protein of unknown function Y26E6A.2 Y26E6A.2 Protein containing an F-box domain, which serve as a link between a target protein and a ubiquitin-conjugating enzyme This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins. Y26G10.1 Y26G10.1 Protein of unknown function, has moderate similarity to C. elegans C50E3.7 Y26G10.2 Y26G10.2 Member of the 7-transmembrane chemoreceptor family of G-protein coupled receptors (GPCR), has high similarity to uncharacterized C. elegans W06D12.7 Y27F2A.2 Y27F2A.2 Putative ortholog of C. elegans F22E5.16 gene product 7TM chemoreceptor, sri family Y27F2A.3 Y27F2A.3 Putative ortholog of C. elegans Y27F2A.H gene product 7TM chemoreceptor, sri family Y27F2A.4 Y27F2A.4 Putative ortholog of C. elegans Y27F2A.G gene product 7TM chemoreceptor, sri family Y27F2A.5 Y27F2A.5 Putative ortholog of C. elegans F33H12.6 gene product Y27F2A.6 Y27F2A.6 Putative ortholog of C. elegans F22E5.1 gene product Y27F2A.7 Y27F2A.7 Putative ortholog of C. elegans Y27F2A.G gene product 7TM chemoreceptor, sri family Y2C2A.1 Y2C2A.1 Putative paralog of C. elegans T23A7.B Y2H9.A mes-4;Y2H9A.1;Y2H9.A Putative G protein-coupled receptor, member of a subfamily with SRD proteins which are expressed in chemosensory neurons, no homolog found in human or D. melanogaster Y2H9.B Y2H9A.3;Y2H9.B Protein containing two collagen triple helix repeats and one nematode cuticle collagen N-terminal domain, has moderate similarity to a region of C. elegans BLI-1, which is a putative collagen Y2H9A.2 Y2H9A.2 Protein of unknown function, has high similarity to uncharacterized C. elegans F53F1.10 7TM chemoreceptor (srd-family) Y32B12A.1 Y32B12A.1 Protein containing a ZZ zinc finger, has moderate similarity to uncharacterized C. elegans T26H2.5 Zinc finger present in dystrophin, CBP/p300 Y32B12A.2 Y32B12A.2 Protein containing a DUF40 domain of unknown function, which contain four conserved cysteines, has high similarity to uncharacterized C. elegans F54B8.9 Y32B12A.3 Y32B12A.3 Member of the type 3 O-methyltransferase family, has high similarity to uncharacterized C. elegans Y40B10A.2 This gene encodes a protein predicted by Eisenberg and coworkers, with 52% accuracy, to be mitochondrial. Y32B12A.4 Y32B12A.4 Protein of unknown function, has weak similarity to C. elegans Y57G7A.3 Y32B12A.5 Y32B12A.5 Protein of unknown function Y32B12B.1 Y32B12B.1 Protein of unknown function, has weak similarity to C. elegans F37B12.3 Y32B12B.2 Y32B12B.2 Protein of unknown function Y32B12B.3 Y32B12B.3 Protein containing a DUF40 domain of unknown function, which contain four conserved cysteines, has high similarity to uncharacterized C. elegans T24A6.5 7TM receptor, srbc family Y32B12B.4 Y32B12B.4 Protein with weak similarity to C. elegans lin-15B (Negative regulator of the LET-23 receptor-tyrosine kinase, LET-60 ras signaling pathway) Y32B12B.5 Y32B12B.5 Member of the 7-transmembrane chemoreceptor family of G-protein coupled receptors (GPCR), has a region of low similarity to C. elegans ODR-10, which is involved in odorant response Y32B12B.6 Y32B12B.6 Protein containing a nuclear hormone receptor ligand-binding domain, has low similarity to C. elegans NHR-51 nuclear hormone receptor Y32B12C.1 Y32B12C.1 Protein with moderate similarity to C. elegans K10G4.3 Y32B12C.2 Y32B12C.2 G protein-coupled receptor of unknown function, no homolog found in human or D. melanogaster 7TM chemoreceptor, srw family Y32B12C.3 Y32B12C.3 Protein containing two DUF38 domains of unknown function and an F-box domain, which serve as a link between a target protein and a ubiquitin-conjugating enzyme, has low similarity to uncharacterized C. elegans F58E2.4 Y32F6A.1 Y32F6A.1 Protein of unknown function, has weak similarity to C. elegans F15E6.1 Y32F6A.2 Y32F6A.2 Protein with weak similarity to serotonin transporter (human SLC6A4), which is a membrane bound sodium- and chloride-coupled transporter that is associated with affective and neurodegenerative disorders Sodium:neurotransmitter symporter family (2 domains); snf-10 encodes a member of the sodium:neurotransmitter symporter family. Y32F6A.3 Y32F6A.3 Protein with high similarity to poly A polymerase beta (mouse Papolb), which is a testis specific poly(A) polymerase that catalyzes the addition of polyadenosine to the 3' end of messenger RNAs POLY(A) POLYMERASE (EC 2.7.7.19) (PAP) (POLYNUCLEOTIDE ADENYLYLTRANSFERASE) Y32F6B.1 Y32F6B.1 Protein containing an organic anion transporter polypeptide (OATP) family N-terminus domain, has weak similarity to multispecific organic anion transporting polypeptide 2 (rat Slc21a5), which transports thyroid hormones and organic anions Y32F6B.2 Y32F6B.2 Protein with high similarity to potassium dependent Na/Ca exchanger (C. elegans F35C12.2), member of the sodium or calcium exchanger protein family of membrane transporters, which regulate intracellular Ca2+ concentrations NA(+)/Ca(2+),K(+)- exchanger Y32F6B.3 Y32F6B.3 Member of the Ras superfamily of GTP-binding proteins, has moderate similarity to C. elegans CDC-42, which is a GTP-binding protein that acts with PAK-1 to mediate hypodermal cell shape changes during embryonic elongation RAS-like GTP-binding protein Y32G9A.2 Y32G9A.2 Protein of unknown function Y32G9A.C Y32G9A.10;Y32G9A.C Protein with moderate similarity to C. elegans F44E5.2 gene product Y32G9A.E Y32G9A.9;Y32G9A.E Putative ortholog of C. elegans B0302.3 gene product Y32G9A.F Y32G9A.8;Y32G9A.F Protein with strong similarity to C. elegans zig-7 gene product Y32G9A.G Y32G9A.7;Y32G9A.G Putative ortholog of C. elegans Y58G8A_207.A gene product Y32G9A.I Y32G9A.5;Y32G9A.I Protein with moderate similarity to C. elegans F12F6.6 gene product Y32G9A.J Y32G9A.4;Y32G9A.J Putative ortholog of C. elegans F20D6.4 gene product Y32G9A.K Y32G9A.3;Y32G9A.K Protein with strong similarity to C. elegans W03F9.3 gene product Y32G9A.M Y32G9A.1;Y32G9A.M Putative ortholog of C. elegans F37B1.2 gene product Y32G9B.1 Y32G9B.1 Putative ortholog of C. elegans Y32G9B.A gene product Y32H12A.1 Y32H12A.1 Protein of unknown function, putative paralog of C. elegans Y32H12A_57.G Y32H12A.2 Y32H12A.2 Putative paralog of C. elegans Y32H12A_56.A Y32H12A.3 Y32H12A_57.F;Y32H12A.F;Y32H12A.3 Member of the short-chain dehydrogenase-reductase family, which are NAD- or NADP-dependent oxidoreductases, has a region of low similarity to a region of mouse Hsd17b4, which is a peroxisomal multifunctional type IV 17 beta-hydroxysteroid dehydrogenase dehydrogenase; dhs-9 encodes a member of the short-chain dehydrogenases/reductases family (SDR). Y32H12A.4 Y32H12A_57.E;Y32H12A.E;Y32H12A.4 Protein with low similarity to protein phosphatase 1 regulatory (inhibitor) subunit 2 (human PPP1R2), which interacts with and inhibits the activity of protein phosphatase 1 gamma (PPP1CC) Y32H12A.5 Y32H12A.5 Putative paralog of C. elegans Y32H12A_57.D Y32H12A.6 Y32H12A_57.B;Y32H12A.B;Y32H12A.6 Protein of unknown function Y32H12A.7 Y32H12A.7 Putative paralog of C. elegans Y32H12A_57.A Y32H12A.8 Y32H12A.8 Putative paralog of C. elegans Y32H12A_57.A Y34B4A.1 Y34B4A.1 Protein of unknown function Y34B4A.10 Y34B4A.10 Protein with weak similarity to C. elegans F13B9.2 gene product Y34B4A.3 Y34B4A.3 Protein of unknown function Y34B4A.4 Y34B4A.4 Putative ortholog of C. elegans cdc-25 gene product Y34B4A.5 Y34B4A.5 Protein with moderate similarity to C. elegans Y119D3B.9 gene product Y34B4A.9 Y34B4A.9 Protein with moderate similarity to C. elegans Y119D3B.9 gene product Y34B4A_2.A Y34B4A.2;Y34B4A_2.A Protein of unknown function, has moderate similarity to uncharacterized C. elegans T23G11.7 Y34B4A_3.A Y34B4A.8;Y34B4A_3.A Protein containing two RhoGAP (GTPase activator domain) domains, has weak similarity to mouse Sh3bp1, which is a protein with GTPase activating activity for the Rac subfamily of Ras-related GTP binding proteins Y34B4A_3.B Y34B4A.7;Y34B4A_3.B Protein with moderate similarity to C. elegans C24A8.3 gene product Y34B4A_3.C Y34B4A.6;Y34B4A_3.C Protein of unknown function, has low similarity to uncharacterized C. elegans Y34B4A.9 Y34B4A_3.D cdc-25;Y34B4A_3.D Putative ras guanine nucleotide releasing factor; putative ortholog of H. sapiens Hs.24117 gene product [ras guanine nucleotide releasing factor] Y34D9A.1 Y34D9A.1 Putative ortholog of C. elegans Y34D9A.F gene product Y34D9A.3 Y34D9A.3 Putative ortholog of C. elegans Y34D9A.I gene product Y34D9A.4 Y34D9A.4 Putative ortholog of C. elegans Y34D9A.D gene product spd-1 encodes a homolog of human PRC1, tobacco MAP-65, and S. cerevisiae Ase1p that is required for embryonic viability due to its requirement for mitotic spindle stability during the late stages of cytokinesis; SPD-1 is also required for fertility, gonad development, locomotion, and vulval development. Y34D9A.A Y34D9A.10;Y34D9A.A Protein of unknown function Y34D9A.B Y34D9A.9;Y34D9A.B Putative ortholog of H. sapiens SKD1 (suppressor of K+ transport defect 1) Y34D9A.C Y34D9A.8;Y34D9A.C Protein of unknown function Y34D9A.J Y34D9A.7;Y34D9A.J Protein with moderate similarity to C. elegans ZK632.11 Y34D9A.K Y34D9A.6;Y34D9A.K Protein with weak similarity to S. cerevisiae TTR1 (Glutaredoxin (thioltransferase, glutathione reductase)) Y34D9A.M Y34D9A.2;Y34D9A.M Protein with weak similarity to H. sapiens GPR37 (G protein-coupled receptor 37 (endothelin receptor type B-like)) Y34D9B.1 mig-1;frizzled-1;Cfz1;F54A5.D;Y34D9B.A;Y34D9B.1 Protein of the mab-5 pathway involved in neuronal cell migration Y34F4.4 Y34F4.4 Putative ortholog of C. elegans Y34F4.a gene product Y34F4.5 Y34F4.5 Protein of unknown function Y34F4.5 Y34F4.B Y34F4.3;Y34F4.B Protein with strong similarity to C. elegans K10D2.2 gene product Y34F4.C Y34F4.c Protein of unknown function Y34F4.E Y34F4.2;Y34F4.E Protein with strong similarity to C. elegans Y34F4.D gene product Y34F4.F Y34F4.1;Y34F4.F Protein with moderate similarity to C. elegans Y34F4.2 gene product Y36E3A.1 Y36E3A.1 Protein containing an F-box domain, which serve as a link between a target protein, and a ubiquitin-conjugating enzyme, and a DUF38 domain of unknown function, has low similarity to uncharacterized C. elegans C08E3.8 This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins; this gene's encoded protein also contains an FTH/DUF38 motif, which may also mediate protein-protein interaction. Y37A1A.1 Y37A1A.1 Member of the transposase family, which are required for excising and inserting mobile genetic elements, has very strong similarity to uncharacterized C. elegans C10H11.2 Transposase Y37A1A.2 Y37A1A.2 Protein of unknown function, has moderate similarity to uncharacterized C. elegans Y11D7A.3 Y37A1A.3 Y37A1A.3 Member of the sugar (and other) transporter family, has low similarity to C. elegans C35A11.4 Sugar (and other) transporters Y37A1B.1 Y37A1B.1 Protein containing a SAP domain, which may bind DNA Y37A1B.10 Y37A1B.10 Protein with similarity to G protein-coupled receptors of unknown function, has strong similarity in the C-terminal region to human mariner transposon EST 7TM chemoreceptor, srw family Y37A1B.11 Y37A1B.11 Member of the ion transport family, which include calcium, sodium, and potassium channels, has a region of weak similarity to a region of potassium channel subfamily K member 5 (human KCNK5), which is an ion channel involved in potassium transport potassium channel protein; egl-23 encodes one of 44 C. elegans TWK (two-P domain K+) potassium channel subunits that contain two pore-forming domains and four transmembrane domains; egl-23 was originally defined by gain-of-function mutations that result in defects in locomotion, egg-laying, and enteric muscle activation; loss of egl-23 function via reversion or RNA-mediated interference (RNAi) does not result in any abnormalities suggesting that EGL-23 may function redundantly with other TWK channels; egl-23 does not, however, interact genetically with the UNC-93 group of TWKs encoded by unc-93, sup-9, and sup-10; the EGL-23 expression pattern is not yet known. Y37A1B.12 Y37A1B.12 Protein of unknown function, has high similarity to uncharacterized C. elegans Y37A1B.13 Y37A1B.13 Y37A1B.13 Protein of unknown function, has high similarity to uncharacterized C. elegans Y37A1B.12 Y37A1B.14 Y37A1B.14 Protein containing two Src homology 3 (SH3) domains, which bind proline-rich peptides, has a region of low similarity to a region of rat Argbp2, which may play a role in linking the actin cytoskeleton to the postsynaptic density Y37A1B.15 Y37A1B.15 Protein containing a RhoGEF (GTPase exchange factor) domain and a Src homology 3 (SH3) domain, which bind proline-rich peptides Src homology domain 3 Y37A1B.2 Y37A1B.2 Protein containing a Src homology 3 (SH3) domain, which bind proline-rich peptides Src homology domain 3 Y37A1B.3 Y37A1B.3 Protein containing a phox protein (PX) domain, which bind phosphoinositides, has a region of low similarity to a region of S. cerevisiae Vps5p, which is a sorting nexin involved in Golgi retention and vacuolar sorting Y37A1B.4 Y37A1B.4 Protein of unknown function Y37A1B.5 Y37A1B.5 Protein of unknown function, has high similarity to uncharacterized rat Selenbp2 Y37A1B.6 Y37A1B.6 Protein of unknown function Y37A1B.7 Y37A1B.7 Protein of unknown function Y37A1B.8 Y37A1B.8 Protein containing a DUF41 domain of unknown function, has high similarity to uncharacterized C. elegans T05A6.4 Y37A1B.9 Y37A1B.9 Protein containing a DUF41 domain of unknown function, has moderate similarity to uncharacterized C. elegans ZK355.4 Y37A1C.1 Y37A1C.1 Protein with moderate similarity to renal sodium-potassium-chloride cotransporter (solute carrier family 12 member 1, human SLC12A1), which mediates renal salt reabsorption and is associated with Bartter's syndrome Amino acid permease; The Y37A1C.1 gene encodes a homolog of the human gene NKCC2, which when mutated leads to hypokalemicalkalosis (OMIM:241200); the Y37A1C.1A protein is predicted to be mitochondrial with 52% accuracy. Y37B11A.1 Y37B11A.1 Protein with strong similarity to C. elegans M142.2 gene product Y37B11A.1 is orthologous to the human gene COLLAGEN TYPE VI, ALPHA 3 CHAIN (COL6A3; OMIM:120250), which when mutated leads to disease. Y37B11A.2 Y37B11A.2 Putative ortholog of C. elegans F10C2.4 gene product Y37B11A.3 Y37B11A.3 Putative ortholog of C. elegans K11H3.3 gene product Y37D8A.1 Y37D8A.1 Protein with moderate similarity to S. cerevisiae Arc18p, which is a component of the ARP2/3 actin-organizing complex that is involved in actin assembly and function Y37D8A.10 Y37D8A.10 Protein of unknown function, has moderate similarity to H. sapiens Hs.77665 gene product Y37D8A.11 Y37D8A.11 Protein with moderate similarity to C. elegans Y37D8A.9 Y37D8A.12 Y37D8A.12 Member of an uncharacterized protein family Y37D8A.13 adm-1;Y37D8A.13 Member of the ADAM (A Disintegrin And Metalloprotease) protein family, has strong similarity to human ADAM15 Disintegrin; unc-71 encodes an ADAM, a disintegrin and metalloprotease-containing transmembrane protein that is a member of the metzincin superfamily of proteases; UNC-71 is required non-cell autonomously for motor axon guidance and sex myoblast migration; UNC-71 does not appear to have an active metalloprotease domain, but functions with UNC-6/netrin and integrins INA-1/PAT-3 to provide guidance cues during axonal migration; UNC-71 is expressed in a restricted pattern in the excretory and excretory gland cells, some head neurons, the sphincter muscles, and hypodermal cells surrounding the vulva. Y37D8A.14 Y37D8A.14 Member of the cytochrome c oxidase subunit Va family, has moderate similarity to uncharacterized cytochrome c oxidase subunit 5a (rat Cox5a), which a putative subunit of the cytochrome c oxidase complex at the mitochondrial inner membrane Y37D8A.15 Y37D8A.15 Member of the FMRFamide related peptide family, which are neuroactive peptides that have a variety of effects flp-14 encodes four copies of a single FMRFamide-related short peptide neurotransmitter; FLP-14 can increase pharyngeal action potential frequency, although its exact role in C. elegans neurotransmission is not yet clear. Y37D8A.16 Y37D8A.16 Protein of unknown function Y37D8A.17 Y37D8A.17 Protein of unknown function, has moderate similarity to uncharacterized mouse 2410089A21Rik Y37D8A.18 Y37D8A.18 Similar to S. cerevisiae Ydr041p, a mitochondrial ribosomal protein Y37D8A.19 Y37D8A.19 Protein of unknown function, has weak similarity to C. elegans ZC373.2 Y37D8A.2 Y37D8A.2 Protein of unknown function, has moderate similarity to uncharacterized C. elegans F09B12.3 Y37D8A.21 Y37D8A.21 Protein containing an RNA recognition motif (RRM, RBD, or RNP), has low similarity to uncharacterized human RBM7 RNA recognition motif. (aka RRM, RBD, or RNP domain) Y37D8A.22 Y37D8A.22 Protein of unknown function Y37D8A.23 unc-25;Y37D8A.23 Glutamic acid decarboxylase expressed in GABAergic neurons Pyridoxal-dependent decarboxylase conserved domain Y37D8A.3 Y37D8A.3 Protein with moderate similarity to C. elegans F42A8.1 gene product Y37D8A.4 Y37D8A.4 Protein with weak similarity to H. sapiens PLCG2 (phospholipase C, gamma 2 (phosphatidylinositol-specific)) Y37D8A.5 Y37D8A.5 Member of a protein family Y37D8A.6 Y37D8A.6 Protein of unknown function, has weak similarity to C. elegans B0348.1 Y37D8A.7 Y37D8A.7 TcA transposase Tc1 transposase Y37D8A.8 Y37D8A.8 Protein with moderate similarity to C. elegans B0348.1 gene product Y37D8A.9 Ce-1;Y37D8A.9 Protein with low similarity to MORF-related gene on chromosome 15 (human MRG15), which is a transcription factor binding protein and putative cell cycle regulator that may play roles in transcription de-repression, cellular aging, and senescence Y37E11A.94.A Y37E11AL.e;Y37E11A.94.a Contains a cadherin domain and an EGF domain Y37E11AL Y37E11AL Protein with moderate similarity to C. elegans M03A8.1 gene product Y37E11AL.5 Y37E11AL.5 Putative ortholog of C. elegans Y37E11AL.f gene product Y37E11AL.7 Y37E11AL.7 Protein with strong similarity to C. elegans Y37E11AL.d gene product Y37E11AL.B Y37E11AL.9;Y37E11AL.B Protein with weak similarity to C. elegans C01F6.5 gene product Y37E11AL.H Y37E11AL.4;Y37E11AL.H Protein with moderate similarity to C. elegans K07E8.1 gene product Y37E11AL.K Y37E11AL.2;Y37E11AL.K Protein with moderate similarity to C. elegans C35D10.8 gene product Y37E11AL.L Y37E11AL.1;Y37E11AL.L Protein with strong similarity to C. elegans T11F9.1 gene product Y37E11AM.3 Y37E11AM.3 Protein of unknown function Y37E11AM.B Y37E11AM.2;Y37E11AM.B Protein of unknown function Y37E11AR.2 sia-1;Y37E11A_93.G;Y37E11AR.2 Protein with high similarity to seven in absentia homolog 2 (human SIAH2), which is a negative regulator of signaling pathways that probably acts via the protein degradation ubiquitin-proteasome pathway, member of the seven in absentia protein family Y37E11AR.3 Y37E11AR.3 Putative ortholog of C. elegans Y37E11AR.4 gene product Y37E11AR.4 Y37E11AR.4 Putative ortholog of C. elegans Y37E11AR.3 gene product Y37E11AR.A Y37E11AR.6;Y37E11AR.A Protein with weak similarity to C. elegans efn-4 (Protein with some similarity to class A and B vertebrate ephrins) Y37E11AR.B Y37E11AR.5;Y37E11AR.B Protein with strong similarity to C. elegans C33A12.6 Y37E11AR.E Y37E11AR.1;Y37E11AR.E Putative paralog of C. elegans C37A5.1 Y37E11B.1 Y37E11B.1 Protein containing five C2H2 type zinc finger domains, which bind nucleic acids, has low similarity to a region of transcription factor 17 (rat Kid1), which is a transcriptional repressor involved in postnatal kidney development and kidney regeneration zinc finger protein Y37E11B.10 Y37E11B.10 Protein with strong similarity to C. elegans Y37E11B.9 gene product Y37E11B.2 Y37E11B.2 Protein of unknown function, has weak similarity to C. elegans W05H12.2 Y37E11B.3 Y37E11B.3 Protein of unknown function Y37E11B.4 taf-2;Y37E11B.4 Ortholog of human and D. melanogaster 150 kDa TATA box binding protein (TBP)-associated factor, predicted cofactor in TFIID-dependent transcription initiation TATA binding protein associated factor; taf-2 encodes a member of the peptidase M1 family, a predicted aminopeptidase with similarity to human TBP-associated factor 2. Y37E11B.5 Y37E11B.5 Putative ortholog of S. cerevisiae Ylr401p, a protein of unknown function This gene encodes a protein predicted by Eisenberg and coworkers, with 52% accuracy, to be mitochondrial. Y37E11B.6 Y37E11B.6 Protein of unknown function Y37E11B.7 Y37E11B.7 Protein of unknown function Y37E11B.9 Y37E11B.9 Protein of unknown function, has moderate similarity to C. elegans Y37E11B.10 Y37E11C.B Y37E11C.2;Y37E11C.B Protein of unknown function, has very strong similarity to a region of C. elegans UNC-33, which is a putative component of the axonal cytoskeleton required for proper axon morphology Y37E11C.C unc-33;Y37E11C.1;Y37E11C.C Putative component of the axonal cytoskeleton required for proper axon morphology; similar to the H. sapiens DPYS gene product Y37E3.1 Y37E3.1 Putative ortholog of C. elegans Y37E3.J gene product Y37E3.10 Y37E3.10 Putative ortholog of C. elegans Y37E3.P gene product Y37E3.11 Y37E3.11 Putative ortholog of C. elegans Y37E3.Q gene product Y37E3.12 Y37E3.12 Putative ortholog of C. elegans Y37E3.F gene product Y37E3.13 Y37E3.13 Protein of unknown function Y37E3.15 Y37E3.15 Putative ortholog of C. elegans Y37E3.S gene product Y37E3.16 Y37E3.16 Putative ortholog of C. elegans Y37E3.D gene product Y37E3.18 Y37E3.18 Putative ortholog of C. elegans C17H11.3 gene product Y37E3.4 Y37E3.4 Protein with strong similarity to C. elegans Y37E3.N gene product Y37E3.5 Y37E3.5 Protein with strong similarity to C. elegans Y37E3.N gene product Y37E3.9 Y37E3.9 Putative ortholog of C. elegans Y37E3.O gene product Y37E3.I Y37E3.7;Y37E3.I Protein with strong similarity to C. elegans Y37E3.I gene product Y37E3.M Y37E3.3;Y37E3.M Protein with strong similarity to C. elegans Y37E3.m gene product Y37E3.U Y37E3.17;Y37E3.U Protein with strong similarity to C. elegans Y106G6H.5 gene product Y37F4.1 Y37F4.1 Putative ortholog of C. elegans W03B1.3 gene product Y37F4.2 Y37F4.2 Protein of unknown function Y37F4.3 Y37F4.3 Protein of unknown function Y37F4.4 Y37F4.4 Protein with weak similarity to C. elegans B0205.10 gene product Y37F4.5 Y37F4.5 Protein of unknown function Y37F4.6 Y37F4.6 Protein of unknown function Y37H2A.1 Y37H2A.1 Putative paralog of C. elegans Y37H2A.B Y37H2A.10 Y37H2A.10 Protein of unknown function, putative paralog of C. elegans Y37H2A.11 Y37H2A.11 Y37H2A.11 Protein of unknown function, putative paralog of C. elegans Y37H2A.M Y37H2A.3 Y37H2A.3 Protein of unknown function, putative paralog of C. elegans Y37H2A.D Y37H2A.4 Y37H2A.E;Y37H2A.4 Protein containing a DUF38 domain of unknown function and an F-box domain, which serve as a link between a target protein and a ubiquitin-conjugating enzyme, has moderate similarity to C. elegans FOG-2, which is required for sexual identity of germ cells This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins; this gene's encoded protein also contains an FTH/DUF38 motif, which may also mediate protein-protein interaction. Y37H2A.5 Y37H2A.F;Y37H2A.5 Protein containing a DUF38 domain of unknown function and an F-box domain, which serve as a link between a target protein and a ubiquitin-conjugating enzyme, has low similarity to C. elegans FOG-2, which is required for the sexual identity of germ cells This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins; this gene's encoded protein also contains an FTH/DUF38 motif, which may also mediate protein-protein interaction. Y37H2A.6 Y37H2A.6 Protein of unknown function, putative paralog of C. elegans Y37H2A.G This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins; this gene's encoded protein also contains an FTH/DUF38 motif, which may also mediate protein-protein interaction. Y37H2A.7 Y37H2A.7 Protein of unknown function, putative paralog of C. elegans Y37H2A.I This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins; this gene's encoded protein also contains an FTH/DUF38 motif, which may also mediate protein-protein interaction. Y37H2A.8 Y37H2A.8 Protein of unknown function, putative paralog of C. elegans Y37H2A.J Y37H2A.9 Y37H2A.K;Y37H2A.9 Protein of unknown function, has moderate similarity to uncharacterized C. elegans M02B7.1 Y37H2B.1 Y37H2B.1 Protein of unknown function, has weak similarity to C. elegans F57G4.1 Y37H2C.1 Y37H2C.1 Protein of unknown function, has weak similarity to uncharacterized C. elegans ZK721.1 Y37H2C.2 Y37H2C.2 Member of the Skp1 family, which serve in targeted protein degradation during the cell cycle, has a region of low similarity to a region of S. cerevisiae Skp1p, which is a component of Cbf3 kinetochore and SCF (Skp1p-cullin-F-box) complexes The skr-6 gene encodes a homolog of Skp1 in S. cerevisiae that has no known function in vivo, since skr-6(RNAi) animals are at least superficially normal. Y37H2C.3 Y37H2C.3 Protein containing an F-box domain, which serve as a link between a target protein and a ubiquitin-conjugating enzyme, and a DUF38 domain of unknown function, has low similarity to C. elegans FOG-2, which is required for the sexual identity of germ cells This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins; this gene's encoded protein also contains an FTH/DUF38 motif, which may also mediate protein-protein interaction. Y37H2C.4 Y37H2C.4 Member of the 7-transmembrane chemoreceptor family of G-protein coupled receptors (GPCR), has high similarity to uncharacterized C. elegans F20E11.4 Y37H9A.1 Y37H9A.1 Protein of unknown function Y37H9A.2 Y37H9A.2 Protein of unknown function Y37H9A.3 Y37H9A.3 Protein of unknown function Y37H9A.6 Y37H9A.6 Member of the Nudix hydrolase family Bacterial mutT protein; The ndx-4 gene encodes a homodimeric diadenosine tetraphosphate (Ap(4)A) hydrolase that belongs to the NUDIX hydrolase family. Y38A10A.5 crt-1;Y38A10A.A;Y38A10A.5 Member of the calreticulin protein family; possibly a molecular chaperone; necessary for germ cell development calreticulin precursor Y38A10A.7 Y38A10A.7 Protein of unknown function Y38A10A.D Y38A10A.3;Y38A10A.D Protein of unknown function, has low similarity to uncharacterized C. elegans R09F10.6 Y38A10A.E Y38A10A.2;Y38A10A.E Member of uncharacterized DUF229 family Y38A10A.F Y38A10A.1;Y38A10A.F Protein of unknown function, has strong similarity to uncharacterized C. elegans F53F1.11 Y38A10A.G Y38A10A.6;Y38A10A.G Protein with high similarity to C. elegans MUT-14, which is involved in RNA catabolism, RNA interference, and the defense response, member of the DEAD or DEAH box ATP-dependent RNA helicase family, contains a helicase conserved C-terminal domain Y38A8.1 Y38A8.1 Member of the bacterial mutT protein family The ndx-3 gene encodes a homolog of peroxisomal CoA diphosphatases in both S. cerevisiae (PCD1) and C. elegans (NDX-8); more generally, NDX-3 protein belongs to the family of NUDIX hydrolases. Y38A8.2 pbs-3;Y38A8.2 Putative beta-type subunit of 20S proteasome particle Peptidase; pbs-3 encodes a B-type subunit of the 26S proteasome's 20S protease core particle; by homology, PBS-3 is predicted to function in ATP/ubiquitin-dependent nonlysosomal protein degradation; loss of pbs-3 activity via large-scale RNAi screens indicates that, in C. elegans, PBS-3 is required for embryonic and germline development, movement, normal body coloration, and normal body morphology. Y38A8.3 Y38A8.3 Protein containing a ubiquitin-like protein-specific protease (Ulp1) family C-terminal catalytic domain, which may bind other protein domains, has a region of weak similarity to a region of sentrin-SUMO specific protease (human SENP1) Y38B5A.A Y38B5A.1;Y38B5A.A Protein with strong similarity to C. elegans F12F3.3 gene product Y38C1AA.1 Y38C1AA.1 Putative ortholog of C. elegans Y38C1AA.J gene product Y38C1AA.A Y38C1AA.10;Y38C1_84.C;Y38C1AA.A Protein of unknown function Y38C1AA.B Y38C1AA.9;Y38C1AA.B Protein with moderate similarity to C. elegans R05G6.9 Y38C1AA.C Y38C1AA.8;Y38C1AA.C Protein of unknown function Y38C1AA.D Y38C1AA.7;Y38C1AA.D Protein of unknown function, has strong similarity to C. elegans F17E9.5 Y38C1AA.E Y38C1AA.6;Y38C1AA.E Protein of unknown function, has moderate similarity to C. elegans F23B2.10 Y38C1AA.F Y38C1AA.5;Y38C1AA.F Putative paralog of C. elegans Y53H1B.1 Y38C1AA.G Y38C1AA.4;Y38C1AA.G Protein of unknown function Y38C1AA.I Y38C1AA.2;Y38C1AA.I Putative ortholog of C. elegans Y38C1_90.A gene product Y38C1AB.1 Y38C1AB.1 Putative paralog of C. elegans Y38C1AB.5 Y38C1AB.2 Y38C1AB.2 Protein of unknown function, putative paralog of C. elegans Y38C1AB.6 Y38C1AB.3 Y38C1AB.3 Protein of unknown function, putative paralog of C. elegans T02H7.8 Y38C1AB.4 Y38C1AB.4 Putative paralog of C. elegans T02H7.5 Y38C1AB.5 Y38C1AB.5 Putative paralog of C. elegans Y38C1AB.1 Y38C1AB.6 Y38C1AB.6 Protein of unknown function, putative paralog of C. elegans Y38C1AB.2 Y38C1AB.7 Y38C1AB.7 Protein of unknown function, putative paralog of C. elegans T02H7.8 Y38C1AB.8 T02H7.9;Y38C1AB.B;Y38C1AB.H;Y38C1AB.8 Protein containing two PDZ, DHR, or GLGF domains, which are found in signaling proteins and one FERM domain (Band 4.1 family), has a region of weak similarity to a region of protein tyrosine phosphatase non-receptor type 13 (mouse Ptpn13) frm-5 encodes a protein that contains a FERM (Band 4.1-ezrin-radixin-moesin) domain near the center of the molecule and two C-terminal PDZ domains; by homology, FRM-5 is predicted to function as a membrane-cytoskeleton linker protein that plays a role in cell adhesion, migration, or organization of cell surface structures; however, as loss of frm-5 activity via large-scale RNAi screens does not result in any obvious abnormalities, the precise role of FRM-5 in C. elegans development and/or behavior is not yet known; the FRM-5 FERM and PDZ domains are most similar to those found in cytoplasmic protein tyrosine phosphatases, even though FRM-5 does not appear to be a phosphatase. Y38C1BA.1 Y38C1BA.1 Protein of unknown function, putative paralog of C. elegans Y38C1_87.E Y38C1BA.2 Y38C1BA.2 Putative paralog of C. elegans syn Y38C1BA.3 Y38C1_87.A;Y38C1BA.A;Y38C1BA.3 Protein with high similarity to C. elegans SQT-3, which is a collagen that is involved in morphogenesis of the epithelium and cuticle synthesis, contains two collagen triple helix repeats and one nematode cuticle collagen N-terminal domain collagen Y38C9A.2 cgp-1;Y38C9A.B;Y38C9A.2 Protein with high similarity to GTP binding protein 1 (human GTPBP1), which is a GTP binding protein that is induced in monocytes by interferon-gamma, contains elongation factor Tu GTP binding, domain 2, and C-terminal domains GTP-binding protein Y38C9A.A W03F9.1;Y38C9A.A Member of an uncharacterized protein family Y38C9A.D Y38C9A.1;Y38C9A.D Protein of unknown function Y38C9B.1 Y38C9B.1 Putative paralog of C. elegans B0331.1 cytochrome P450 Y38C9B.2 Y38C9B.2 Protein of unknown function, putative paralog of C. elegans F18E2.4 7TM chemoreceptor, srt family Y38C9B.3 Y38C9B.3 Protein of unknown function, has weak similarity to C. elegans T26E4.1 Y38E10A.6 Y38E10A.6 Protein with weak similarity to C. elegans unc-89, a muscle cell protein of the immunoglobulin-like protein family that is required for coordinated locomotion Y38E10A.C Y38E10A.3;Y38E10A.C Protein with moderate similarity to C. elegans F56D5.5 gene product Y38E10A.D Y38E10A.4;Y38E10A.D Putative ortholog of C. elegans F10G2.3 gene product Y38E10A.E Y38E10A.5;Y38E10A.E Putative ortholog of C. elegans B0454.7 gene product Y38E10A.G Y38E10A.7;Y38E10A.G Putative ortholog of C. elegans C09E8.2 gene product Y38E10A.H Y38E10A.8;Y38E10A.H Protein with strong similarity to C. elegans pek-1 gene product Y38E10A.I Y38E10A.9;Y38E10A.I Protein of unknown function Y38E10A.V rgs-4;Y38E10A.21;Y38E10A.V Protein with similarity to regulators of G protein signaling Y38E10A.X Y38E10A.23;Y38E10A.X Protein of unknown function Y38E10A.Y Y38E10A.24;Y38E10A.Y Protein of unknown function Y38F1A.1 Y38F1A.A;Y38F1A.1 Protein of unknown function Y38F1A.3 ptr-18;Y38F1A.E;Y38F1A.3 Putative paralog of C. elegans Y38F1A.3, has strong similarity to a number of C. elegans proteins and may be related to H. sapiens NPC1 which is involved in Niemann-Pick disease, type C1 Y38F1A.4 Y38F1A.D;Y38F1A.4 Protein of unknown function Y38F1A.5 cyd-1;Y38F1A.F;Y38F1A.5 Probably a Cyclin D homolog; required for postembryonic G1/S progression Cyclins; cyd-1 encodes a cyclin D homolog that is required for escape from G1 cycle arrest in postembryonic blast cells, affects movement and larval viability, and may physically interact with CDK-46 and CKI-1; expressed embryonically primarily in the head, ventral cord, tail, and is later expressed primarily in the seam cells and in the somatic gonad. Y38F1A.6 Y38F1A.G;Y38F1A.6 Putative alcohol dehydrogenase Iron-containing alcohol dehydrogenases Y38F1A.7 Y38F1A.H;Y38F1A.7 Protein of unknown function Y38F1A.8 Y38F1A.I;Y38F1A.8 Protein of unknown function, has weak similarity to uncharacterized FGF receptor activating protein 1 (human FRAG1) Y38F1A.9 Y38F1A.J;Y38F1A.9 Protein containing an immunoglobulin (Ig) domain, which may be involved in protein-protein and protein-ligand interactions Y38F1A.B Y38F1A.2;Y38F1A.B Protein containing a C3HC4 type (RING) zinc finger, which may mediate protein-protein interactions Y38F1A.K F18A11.5;Y38F1A.K Member of the Skp1 family, which are required for targeted protein degradation during the cell cycle, contains a K+ channel tetramerization domain, which facilitate assembly of alpha-subunits into functional tetrameric channels Y38F1A.L Y38F1A.10;Y38F1A.L Protein containing a protein kinase domain, has low similarity to S. cerevisiae Ipl1p, which is a serine-threonine protein kinase of the mitotic spindle that functions in chromosome segregation and activation of the spindle checkpoint Y38F1A.M F18A11.4;Y38F1A.M Protein of unknown function Y38F2AL.B Y38F2AL.5;Y38F2AL.B Protein of unknown function Y38F2AL.C Y38F2AL.4;Y38F2AL.C Putative paralog of C. elegans vha-3 Y38F2AL.E Y38F2AL.3;Y38F2AL.E Putative paralog of VHA-11; putative ortholog of S. cerevisiae Vma5p, Vacuolar H(+)-ATPase hydrophilic subunit C Y38F2AL.F Y38F2AL.2;Y38F2AL.F Protein with moderate similarity to D. melanogaster CG9227 (CG9227 gene product) Y38F2AL.H Y38F2AL.1;Y38F2AL.H Protein of unknown function, putative paralog of C. elegans Y67A10A.9 Y38F2AR.5 Y38F2AR.5 Protein with strong similarity to C. elegans Y38F2AR.J gene product Y38F2AR.A Y38F2AR.12;Y38F2AR.A Protein of unknown function Y38F2AR.B Y38F2AR.11;Y38F2AR.B Protein of unknown function Y38F2AR.C Y38F2AR.10;Y38F2AR.C Protein with moderate similarity to C. elegans F58E6.5 gene product Y38F2AR.G Y38F2AR.8;Y38F2AR.G Putative ortholog of C. elegans Y35H6.1 gene product Y38F2AR.H Y38F2AR.7;Y38F2A_5743.B;Y38F2AR.H Member of the AAA ATPase and M41 peptidase families, has moderate similarity to a region of S. cerevisiae Afg3p, which is a mitochondrial protein that acts in inner membrane proteolytic and chaperonin activities and in respiratory chain complex assembly Y38F2AR.I Y38F2AR.6;Y38F2A_5743.K;Y38F2AR.I Protein with strong similarity to C. elegans Y35H6.3 gene product Y38F2AR.K Y38F2AR.4;Y38F2AR.K Putative ortholog of C. elegans R07H5.6 gene product Y38F2AR.M Y38F2AR.2;Y38F2AR.M Protein of unknown function Y38F2AR.N Y38F2AR.1;Y38F2AR.N Protein with strong similarity to C. elegans F22D6.6 gene product Y38F2A_5743.E vha-3;Y38F2A_5743.E Putative vacuolar-type H+ ATPase Y38F2A_5743.G vha-11;Y38F2A_5743.F;Y38F2A_5743.G Required for embryogenesis and oocyte ovulation and a putative ortholog of S. cerevisiae VMA5 gene product [Vacuolar H(+)-ATPase (V-ATPase) hydrophilic subunit (subunit C), 42 kDa subunit of V1 sector] Y38F2A_6126.E Y38F2AR.9;Y38F2AR.E;Y38F2A_6126.E Protein with high similarity to protein translocation complex beta (human SEC61B), which facilitates cotranslational ER translocation of nascent proteins and may mediate retrograde transport of mis-folded proteins for cytosolic proteolysis Y38F2A_6126.H Y38F2AR.3;Y38F2AR.L;Y38F2A_6126.H Protein of unknown function Y38H6A.1 Y38H6A.1 Member of an uncharacterized protein family Y38H6A.2 Y38H6A.2 Protein of unknown function Y38H6A.3 Y38H6A.3 Protein of unknown function Y38H6C.1 Y38H6C.1 Protein of unknown function, has high similarity to uncharacterized C. elegans M02H5.8 Y38H6C.10 Y38H6C.10 Protein containing an F-box domain, which serve as a link between a target protein and a ubiquitin-conjugating enzyme, has moderate similarity to uncharacterized C. elegans Y38H6C.11 This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins. Y38H6C.11 Y38H6C.11 Protein containing an F-box domain, which serve as a link between a target protein and a ubiquitin-conjugating enzyme, has moderate similarity to uncharacterized C. elegans Y38H6C.10 This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins; this gene's encoded protein also contains an FTH/DUF38 motif, which may also mediate protein-protein interaction. Y38H6C.12 Y38H6C.12 Member of the 7-transmembrane chemoreceptor family of G-protein coupled receptors (GPCR), has high similarity to uncharacterized C. elegans F57G8.3 Y38H6C.13 Y38H6C.13 Protein containing an F-box domain, which serve as a link between a target protein and a ubiquitin-conjugating enzyme, has low similarity to uncharacterized C. elegans Y38H6C.11 Y38H6C.14 Y38H6C.14 Protein of unknown function Y38H6C.15 Y38H6C.15 Protein of unknown function, has weak similarity to C. elegans AH6.3 Y38H6C.16 Y38H6C.16 Protein of unknown function, has high similarity to uncharacterized C. elegans ZK84.2 Y38H6C.17 Y38H6C.17 Member of the transmembrane amino acid transporter (permease) family, has low similarity to lysosomal amino acid transporter 1 (rat Lyaat1), which transports small neutral amino acids and some neurotransmitters Y38H6C.18 Y38H6C.18 Protein of unknown function Y38H6C.19 Y38H6C.19 Protein of unknown function, has moderate similarity to uncharacterized C. elegans Y54E2A.9 Y38H6C.2 Y38H6C.2 Protein of unknown function, has moderate similarity to uncharacterized C. elegans F18E3.5 7TM chemoreceptor, srw family Y38H6C.20 Y38H6C.20 Protein containing a protein kinase domain, has a region of low similarity to a region of fibroblast growth factor receptor 1 (human FGFR1), which is a receptor tyrosine kinase that binds fibroblast growth factors and is involved in cell proliferation protein tyrosine kinase Y38H6C.21 Y38H6C.21 Protein of unknown function, has low similarity to uncharacterized C. elegans ZK697.1 Y38H6C.22 Y38H6C.22 Protein of unknown function, has high similarity to uncharacterized C. elegans T22H6.5 abf-4 encodes a homolog of the antibacterial factor ASABF from Ascaris suum; ABF-4 may play a role in innate immunity, though at present the only evidence for its having an antimicrobial humoral function is its sequence similarity. Y38H6C.3 Y38H6C.3 Protein of unknown function, has moderate similarity to uncharacterized C. elegans K07C11.10 Y38H6C.4 Y38H6C.4 Protein of unknown function Y38H6C.5 Y38H6C.5 Protein containing a zinc knuckle domain, which can bind RNA or DNA in eukaryotes Zinc finger, CCHC class Y38H6C.6 Y38H6C.6 Protein of unknown function, has very strong similarity to uncharacterized C. elegans F30F8.4 transposase Y38H6C.7 Y38H6C.7 Protein of unknown function, has weak similarity to C. elegans C01G10.13 Y38H6C.8 Y38H6C.8 Protein containing a C-type lectin domain, has weak similarity to human REG1A and REG1B (regenerating islet-derived 1, alpha and beta), has strong similarity to C. elegans C54D1.2 Lectin C-type domain short and long forms Y38H6C.9 Y38H6C.9 Protein containing a DUF38 domain of unknown function, has moderate similarity to uncharacterized C. elegans Y38H6C.11 Y38H8A.1 Y38H8A.1 Protein of unknown function Y38H8A.2 Y38H8A.2 Protein of unknown function, has low similarity to uncharacterized C. elegans F10E9.2 Zinc finger, C3HC4 type (RING finger) Y38H8A.3 Y38H8A.3 Protein containing a protein kinase domain, has low similarity to S. pombe Hhp2p, which is a casein kinase I homolog involved in DNA repair serine/threonine kinase Y38H8A.4 Y38H8A.4 Protein containing a protein kinase domain, has moderate similarity to serine threonine kinase 22b (mouse Stk22b), which is a serine/threonine kinase involved in the cytodifferentiation of late spermatids into sperm serine/threonine kinase Y38H8A.5 Y38H8A.5 Protein containing six C2H2 type zinc finger domains, which bind nucleic acids, has high similarity to a region of zinc finger protein 85 (human ZNF85), which functions as a transcriptional co-repressor Zinc finger, C2H2 type (2 domains); The Y38H8A.5 gene encodes a homolog of the human gene ZNF195 (or p57KIP2), which when mutated leads to Beckwith-Wiedemann syndrome (OMIM:130650). Y39A1A.1 Y39A1A.1 Protein of unknown function, has weak similarity to uncharacterized S. pombe Spac458.06p Y39A1A.10 Y39A1A.10 Protein of unknown function Y39A1A.11 Y39A1A.11 Member of the alcohol/ribitol dehydrogenase-like protein family Alcohol/other dehydrogenases, short chain type, Short chain dehydrogenase/reductase C-terminus; dhs-11 encodes a short-chain dehydrogenase predicted to be mitochondrial. Y39A1A.12 Y39A1A.12 Member of the ATPase family associated with various cellular activities, has low similarity to origin recognition complex subunit 1-like (human ORC1L), which is required for initiation of DNA replication and may mediate the acetylation state of chromatin ATPases associated with various cellular activities (AAA); Y39A1A.12 encodes a homolog of origin recognition complex 1, which is also a distant paralog of CDC-6; both Y39A1A.12 and CDC-6 encode homologs of the origin complex which, in yeast, controls the start of DNA replication; whether either Y39A1A.12 or CDC-6 are required for this function in C. elegans, individually or in parallel, is unknown. Y39A1A.13 Y39A1A.13 Protein of unknown function Y39A1A.14 Y39A1A.14 Has strong similarity to S. cerevisiae Emg1p, a protein involved in 18S rRNA maturation and 40S ribosomal subunit formation Y39A1A.15 cnt-2;Y39A1A.15 Protein containing 6 ankyrin (Ank) repeats, 3 pleckstrin homology (PH) domains, and 3 putative arf GTPase activation (GAP) domains, has a region of low similarity to a region of phosphoinositide 3-kinase enhancer (rat Pike), which is a nuclear GTPase Ank repeat (2 domains) Y39A1A.16 Y39A1A.16 Protein containing an F-box domain, which serve as a link between a target protein and a ubiquitin-conjugating enzyme, has high similarity to uncharacterized C. elegans F21D9.1 This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins. Y39A1A.17 Y39A1A.17 Protein of unknown function, has a region of low similarity to a region of C. elegans ZYG-11, which is a protein required for zygote formation Leucine Rich Repeat (2 copies) (2 domains) Y39A1A.18 Y39A1A.18 Protein with strong similarity to C. elegans K10C9.7 gene product Y39A1A.19 Y39A1A.19 Member of the flavin-binding monooxygenase family, which are xenobiotic-metabolising enzymes, has moderate similarity to flavin containing monooxygenase 5 (human FMO5), which catalyzes soft nucleophilic substance monooxygenation and oxidizes N-octylamine DIMETHYLANILINE MONOOXYGENASE (N-OXIDE FORMING) 5 (EC 1.14.13.8) (HEPATIC FLAVIN-CONTAINING MONOOXYGENASE 5) (FMO 5) (DIMETHYLANILINE OXIDA ..; The fmo-13 gene encodes a homolog of the human genes FMO1, FMO2, and FMO3, which when mutated lead to trimethylaminuria (OMIM:602079). Y39A1A.2 Y39A1A.2 Protein of unknown function Y39A1A.20 Y39A1A.20 Protein of unknown function Y39A1A.21 Y39A1A.21 Protein of unknown function Y39A1A.22 Y39A1A.22 Protein with high similarity to xenotropic and polytropic retrovirus receptor 1 (human XPR1), which acts as a viral receptor, contains an ERD1, XPR1, and SYG1 (EXS) domain and a SYG1, Pho81 and XPR1 (SPX) N-terminal domain Y39A1A.23 hpr-9;Y39A1A.23 Putative DNA repair protein, involved in DNA damage and replication checkpoints; strongly similar to C. elegans RAD-9 Y39A1A.3 Y39A1A.3 Protein of unknown function, has similarity to human p27 autoantigen (Hs.25723) involved in scleroderma and/or Sjogren's syndrome Y39A1A.4 Y39A1A.4 Protein containing an A20-like zinc finger domain Y39A1A.5 Y39A1A.5 Protein containing a vacuolar sorting protein 9 (VPS9) domain, which may interact with small GTPases Y39A1A.6 Y39A1A.6 Protein of unknown function Y39A1A.7 Y39A1A.7 Protein of unknown function, has low similarity to uncharacterized C. elegans Y53H1B.A Y39A1A.8 Y39A1A.8 Member of the MtN3-saliva family, which contain a region of two transmembrane helices, has low similarity to uncharacterized human LOC55974 Y39A1A.9 Y39A1A.9 Protein of unknown function Y39A1B.1 Y39A1B.1 Member of the C-type lectin protein family Lectin C-type domain short and long forms, von Willebrand factor type A domain Y39A1B.2 ptr-19;Y39A1B.2 Member of the patched family, which are transmembrane receptors, has weak similarity to human NPC1, which is a lysosomal protein that plays a role in cholesterol transport and is associated with Niemann-Pick type C1 disease Y39A1B.3 Y39A1B.3 Putative ortholog of C. elegans dpy-28 gene product dpy-28 encodes a non-SMC condensin subunit homolog, similar to XCAP-D2 in Xenopus, Cnd1 in S. pombe, and Ycs4p in S. cerevisiae, that is required for negative, chromosome-wide regulation of X-chromosomal genes in XX but not XO animals (dosage compensation), and for some undetermined aspect of body morphogenesis; DPY-28 is part of a multiprotein 'dosage compensation' complex with DPY-26, DPY-27 and MIX-1. Y39A1B.4 Y39A1B.4 Protein of unknown function Y39A1C.1 Y39A1C.1 Protein of unknown function Y39A1C.2 oxi-1;Y39A1C.2 Protein with similarity to ubiquitin-protein ligases HECT-domain (ubiquitin-transferase). Y39A1C.3 Y39A1C.3 Protein containing a cold-shock nucleic acid binding domain, which bind both single-stranded DNA and single-stranded RNA, has moderate similarity to cold shock domain protein A (mouse Csda), which is a transcriptional repressor 'Cold-shock' DNA-binding domain Y39A1C.4 Y39A1C.4 Protein of unknown function, has low similarity to uncharacterized C. elegans Y70D2A.2 Y39A3A.2 Y39A3A.2 Putative ortholog of C. elegans Y44A6B.3 gene product Y39A3A.B Y39A3A.4;Y39A3A.B Putative tyrosine protein phosphatase, possible paralog of C. elegans Y67D8A_377.A Y39A3A.C Y39A3A.3;Y39A3A.C Protein with moderate similarity to C. elegans Y40B10B.B gene product Y39A3A.D Y39A3A.1;Y39A3A.D Member of the transposase family, which are required for excising and inserting mobile genetic elements, has high similarity to uncharacterized C. elegans Y59E1A.3 Y39A3B.3 Y39A3B.3 Protein with unknown function Y39A3B.4 Y39A3B.4 Protein with unknown function 7TM chemoreceptor, srd family Y39A3B.A Y39A3B.5;Y39A3B.A Member of the rhodopsin family of G-protein coupled receptors (GPCR), has low similarity to cholecystokinin A receptor (mouse Cckar), which activates phospholipase C to regulate stress and satiety and is associated with hyperglycemia and hyperinsulinemia Y39A3B.H Y39A3B.2;Y39A3B.H Protein containing a neurotransmitter-gated ion-channel transmembrane and ligand binding domains, has moderate similarity to glycine receptor alpha 1 (rat Glra1), which is a subunit of glycine-gated chloride channel acting in inhibitory neurotransmission Y39A3B.I Y39A3B.1;Y39A3B.I Protein of unknown function Y39A3CL.1 Y39A3CL.1 Protein with weak similarity to C. elegans dig-1 (Protein involved in gonad development, and a member of the Immunoglobulin superfamily) Y39A3CL.2 Y39A3CL.2 Protein with strong similarity to H. sapiens PRAX-1 (peripheral benzodiazepine receptor-associated protein 1) Y39A3CL.3 Y39A3CL.3 Protein of unknown function Y39A3CL.4 Y39A3CL.4 Putative ortholog of C. elegans Y39A3CL.4 gene product Y39A3CL.5 Y39A3CL.5 Putative ortholog of D. melanogaster CalpB (Calpain-B) clp-4 encodes a large calpain subunit that is homologous to Drosophila CalpainB and the mammalian muscle-specific Calpain 3 proteins (OMIM:114240, mutations are associated with limb-girdle muscular dystrophy); by homology, CLP-4 is predicted to function as a nonlysosomal, calcium-dependent, cysteine protease that is involved in intracellular proteolysis and peptidolysis; however, as loss of clp-4 activity via RNA-mediated interference (RNAi) does not result in any obvious abnormalities, the precise role of CLP-4 in C. elegans development and/or behavior is not yet known. Y39A3CL.6 Y39A3CL.6 Protein with weak similarity to H. sapiens PDGFA (platelet-derived growth factor alpha polypeptide) Y39A3CL.7 Y39A3CL.7 Protein of unknown function Y39A3CR.1 Y39A3CR.1 Protein of unknown function, has weak similarity to C. elegans T01A4.D Y39A3CR.3 Y39A3CR.3 Protein with weak similarity to D. melanogaster BcDNA:LD21719 (Protein of unknown function) Y39A3CR.4 Y39A3CR.4 Protein with weak similarity to H. sapiens DFN1 (deafness, X-linked 1, progressive) ddp-1 encodes the C. elegans ortholog of Saccharomyces cerevisiae Tim8p and human deafness/dystonia peptide (DDP; OMIM:300356, mutated in Mohr-Tranebjaerg syndrome); by homology, DDP-1 is predicted to be part of a heterooligomeric complex that localizes to the mitochondrial intermembrane space and facilitates translocation of proteins from the cytosol to the inner mitochondrial membrane; loss of ddp-1 activity via large-scale RNAi screens does not result in any obvious abnormalities, indicating that ddp-1 is not essential for C. elegans development or may function redundantly with its paralogs, TIN-9, -10, and -13. Y39A3CR.5 Y39A3CR.5 Protein of unknown function Y39A3CR.6 Y39A3CR.6 Contains a basic helix-loop-helix DNA-binding domain Y39A3CR.7 Y39A3CR.7 Protein with weak similarity to C. elegans T05A10.1 (Protein containing C2H2-type zinc finger domains, has similarity to D. melanogaster transcription factor SHN (schnurri), has similarity to a region of human HIVEP1, immunodeficiency virus type I enhancer-binding protein 1) The protein product of this gene is predicted to contain a glutamine/asparagine (Q/N)-rich ('prion') domain, by the algorithm of Michelitsch and Weissman (as of the WS77 release of WormBase, i.e., in wormpep77). Y39A3CR.8 Y39A3CR.8 Protein with weak similarity to C. elegans C52B9.8 (Putative helicase, strongly related to chromatin remodeling and transcription activation proteins of the SNF2/RAD54 family) Y39B6.L Y39B6A.29;Y39B6A.O;Y39B6B.L;Y39B6.L Protein of unknown function, has high similarity to uncharacterized C. elegans B0554.5 Y39B6.N Y39B6A.31;Y39B6A.M;Y39B6B.N;Y39B6.N Protein of unknown function, has low similarity to uncharacterized C. elegans Y43F8A.2 Y39B6.Q Y39B6A.35;Y39B6A.J;Y39B6B.Q;Y39B6.Q Member of the queuine tRNA-ribosyltransferase family, which modify tRNAs for asparagine, aspartic acid, histidine and tyrosine with queuine, has low similarity to uncharacterized human FLJ12960 Y39B6.W Y39B6A.10;Y39B6A.EE;Y39B6B.W;Y39B6.W Putative ortholog of C. elegans B0413.5 gene product Y39B6.Z Y39B6A.7;Y39B6A.HH;Y39B6B.Z;Y39B6.Z Putative ortholog of C. elegans B0413.B gene product Y39B6A.D Y39B6A.41;Y39B6A.D Protein with strong similarity to C. elegans K09C4.5 gene product Y39B6A.F Y39B6A.39;Y39B6A.F Possible mitochondrial small subunit protein Y39B6A.JJ tsp-13;Y39B6A.6;Y39B6B.AA;Y39B6A.JJ Putative ortholog of C. elegans B0413.2 gene product Y39B6A.KK Y39B6A.5;Y39B6B.BB;Y39B6A.KK Protein with strong similarity to C. elegans B0413.1 gene product Y39B6A.MM hot-2;Y39B6B.DD;Y39B6A.MM Ly-6-related protein Y39B6A.W nhr-95;Y39B6.D;Y39B6B.D;Y39B6A.W Protein of unknown function, has a region of low similarity to a region of C. elegans NHR-58, which is a nuclear hormone receptor that is involved in embryogenesis and morphogenesis Y39B6A.X Y39B6A.47;Y39B6B.C;Y39B6.C;Y39B6A.X Protein containing a nuclear hormone receptor C4-type zinc finger domain, which bind DNA and may regulate transcription, has a region of high similarity to a region of C. elegans T23H2.1, which is involved in embryogenesis and morphogenesis Y39B6A.Y Y39B6.B;Y39B6B.B;Y39B6A.Y Protein with weak similarity to D. melanogaster EG:95B7.5 Y39B6B.CC Y39B6A.4;Y39B6A.LL;Y39B6B.CC Protein of unknown function Y39B6B.EE Y39B6A.3;Y39B6A.NN;Y39B6B.EE Protein of unknown function Y39B6B.FF Y39B6A.2;Y39B6A.OO;Y39B6B.FF Putative ortholog of C. elegans pef-1 gene product Y39B6B.G asp-1;Y39B6A.20;Y39B6A.T;Y39B6.G;Y39B6B.G Probable aspartyl protease Y39B6B.GG Y39B6A.1;Y39B6A.PP;Y39B6B.GG Protein with strong similarity to C. elegans T02H6.3 gene product Y39B6B.O Y39B6A.33;Y39B6A.L;Y39B6.O;Y39B6B.O Protein of unknown function, has weak similarity to S. cerevisiae Ypl146p Y39B6B.S Y39B6A.13;Y39B6A.AA;Y39B6.S;Y39B6B.S Protein of unknown function Y39B6B.V Y39B6A.11;Y39B6A.DD;Y39B6.V;Y39B6B.V Putative ortholog of C. elegans B0413.E gene product Y39B6B.X Y39B6A.9;Y39B6A.FF;Y39B6.X;Y39B6B.X Protein of unknown function, has weak similarity to a region of S. cerevisiae Ddr48p, which is a stress protein induced by heat shock, DNA damage, or osmotic stress Y39C12A.1 Y39C12A.1 Putative paralog of C. elegans Y39C12.A Y39C12A.2 Y39C12.B;Y39C12A.B;Y39C12A.2 Protein containing two ankyrin (Ank) repeats, which may mediate protein-protein interactions Y39C12A.3 Y39C12.C;Y39C12A.C;Y39C12A.3 Member of the C. elegans Sre G protein-coupled chemoreceptor family, which are putative chemosensory receptors, has high similarity to uncharacterized C. elegans Y39C12A.6 7TM receptor, sre family Y39C12A.4 Y39C12.D;Y39C12A.D;Y39C12A.4 Member of the C. elegans Sre G protein-coupled chemoreceptor family, which are putative chemosensory receptors Y39C12A.5 Y39C12.E;Y39C12A.E;Y39C12A.5 Member of the C. elegans Sre G protein-coupled chemoreceptor family, which are putative chemosensory receptors, has moderate similarity to uncharacterized C. elegans Y39C12A.6 7TM receptor, sre family Y39C12A.6 Y39C12A.6 Protein of unknown function, putative paralog of C. elegans Y39C12.F 7TM receptor, sre family Y39C12A.7 Y39C12A.7 Protein of unknown function, has moderate similarity to C. elegans Y39C12A.6 7TM receptor, sre family Y39C12A.8 Y39C12A.8 Putative paralog of C. elegans Y39C12.G This gene encodes a protein containing a DnaJ ('J') domain. Y39C12A.9 Y39C12A.9 Protein of unknown function Y39D8A.1 Y39D8A.1 Protein of unknown function, has strong similarity to uncharacterized C. elegans B0554.5 Y39D8B.1 Y39D8B.1 Protein of unknown function, putative paralog of C. elegans Y39D8B.2 Y39D8B.2 Y39D8B.2 Protein of unknown function, putative paralog of C. elegans Y39D8B.3 Y39D8B.3 Y39D8B.3 Protein of unknown function, putative paralog of C. elegans Y39D8B.2 Y39D8C.1 Y39D8C.1 Member of the ABC transporter family, has low similarity to ATP binding cassette subfamily A member 1 (human ABCA1), which mediates the transport of cholesterol, phospholipids and anions and is associated with Tangier disease upon gene mutation ABC transporter; The abt-4 gene encodes a putative ABC transporter homologous to human ABCR; mutation of human ABCR leads to Stargardt disease (OMIM:248200) or Tangier disease (OMIM:205400). Y39E4A.1 Y39E4A.1 Protein of unknown function, has high similarity to uncharacterized C. elegans Y71G12B.3 Y39E4A.2 Y39E4A.2 Protein with high similarity to zinc transporter 2 (rat Slc30a2), which transports zinc into vesicles and may protect cells from zinc toxicity, member of the cation efflux family, which may be membrane divalent cation transporters Y39E4A.3 Y39E4A.3 Protein with high similarity to branched-chain alpha-keto acid dehydrogenase E1 alpha subunit (mouse Bckdha), member of the dehydrogenase E1 family, which are thiamine pyrophosphate (TPP)-dependent dehydrogenase complex components Transketolase; Y39E4A.3 is orthologous to the human gene MAPLE SYRUP URINE DISEASE, TYPE IA (MSUD, TYPE IA; E1-alpha subunit of branched-chain keto acid dehydrogenase; OMIM:248600), which when mutated leads to maple syrup urine disease; Y39E4A.3 protein is predicted to be mitochondrial. Y39E4B.11 Y39E4B.O;Y39E4B.11 Protein of unknown function Y39E4B.12 Y39E4B.12 Putative paralog of C. elegans gly-5 (N-acetylgalactosaminyltransferase) gly-5 encodes a predicted member of the UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase (ppGaNTase) family. Y39E4B.13 Y39E4B.C;Y39E4B.13 Protein with moderate similarity to C. elegans Y57G11C.8 gene product Y39E4B.6 Y39E4B.A;Y39E4B.6 Protein of unknown function Y39E4B.8 Y39E4B.8 Putative member of Immunoglobulin superfamily Y39E4B.9 Y39E4B.G;Y39E4B.9 Member of the galactosyltransferase family, has a region of low similarity to a region of UDP-galactose:beta-N-acetylglucosamine beta-1,3-galactosyltransferase (human B3GALT1), which is specific for beta-linked acceptors and is low in some colon cancers bre-2 is required for Cry5B toxicity. Y39E4B.D Y39E4B.3;Y39E4B.D Protein with moderate similarity to C. elegans Y39E4B.B gene product Y39E4B.E Y39E4B.7;Y39E4B.E Protein containing a DHHC-type zinc finger (NEW1) domain, has a region of low similarity to a region of S. cerevisiae Erf2p, which is a protein involved in palmitoylation and localization of S. cerevisiae Ras2p Y39E4B.H Y39E4B.10;Y39E4B.H Protein of unknown function Y39E4B.I Y39E4B.1;Y39E4B.I Member of the ATP-binding cassette (ABC) superfamily, putative ortholog of human Rnase L inhibitor (RLI) of the interferon-regulated 2-5A pathway, putative ortholog of S. cerevisiae Ydr091p Y39E4B.J Y39E4B.14;Y39E4B.J Protein of unknown function Y39E4B.K Y39E4B.2;Y39E4B.K Protein of unknown function, has moderate similarity to uncharacterized C. elegans R05F9.11 Y39E4B.L Y39E4B.5;Y39E4B.L Member of the hexose transporter family of the major facilitator superfamily [MFS] Y39E4B.N gly-5;Y39E4B.M;Y39E4B.N N-acetylgalactosaminyltransferase Y39E4B.P Y39E4B.4;Y39E4B.P Member of the tetraspanin family, which contain an N-terminal transmembrane domain that is a signal sequence and membrane anchor, has weak similarity to rat Cd81, which plays a role in cell adhesion and in glial scar formation Y39F10A.3 Y39F10A.3 Putative ortholog of C. elegans Y55F3AM.11 gene product Y39F10A.4 Y39F10A.4 Tc1 Transposase transposase Y39F10A.A Y39F10A.2;Y39F10A.A Protein with strong similarity to C. elegans F08A8.5 gene product Y39F10A.B Y39F10A.1;Y39F10A.B Protein of unknown function Y39F10B.1 Y39F10B.1 Putative paralog of C. elegans Y39F10B_187.D Y39F10C.1 Y39F10C.A;Y39F10C.1 Protein with strong similarity to C. elegans Y40B10B.B gene product Y39G10AL.1 Y39G10AL.1 Protein with moderate similarity to C. elegans Y39G10AL.C gene product Y39G10AL.3 Y39G10AL.3 Putative ortholog of C. elegans cdk-7 gene product The cdk-7 gene encodes a cyclin-dependent kinase orthologous to human CDK7 (OMIM:601955) that is a component of the general transcription factor IIH (TFIIH) complex; CDK-7 is required during embryogenesis for mRNA transcription and phosphorylation of RNA polymerase II on serine 2 and serine 5, as well as for cell cycle progression, maintenance of ploidy, and completion of meiosis following fertilization. Y39G10AL.B Y39G10AL.2;Y39G10AL.B Protein with weak similarity to H. sapiens ABCR (ATP binding cassette transporter) Y39G10AR.10 Y39G10AR.10 Protein of unknown function Y39G10AR.12 Y39G10AR.12 Protein of unknown function Y39G10AR.13 Y39G10AR.13 Putative ortholog of C. elegans icp-1 gene product The icp-1 gene encodes a 'chromosomal passenger protein'; inactivation of icp-1 by RNAi leads to a complete failure of chromosome segregation during the first mitotic division of embryonic development. Y39G10AR.14 Y39G10AR.14 Putative ortholog of C. elegans Y17G7B.5 gene product mcm-4 encodes a member of the MCM2/3/5 family with similarity to human MCM4 minichromosome maintenance deficient 4 protein, and affects embryonic viability, nuclear morphology in early embryos, and larval viability. Y39G10AR.2 Y39G10AR.2 Protein of unknown function Y39G10AR.20 Y39G10AR.20 Protein of unknown function Y39G10AR.21 Y39G10AR.21 Protein with moderate similarity to C. elegans W07E6.1 gene product Y39G10AR.21 is orthologous to the human gene SIMILAR TO RIKEN CDNA 2810405F18 GENE (FAAH; OMIM:602935), which when mutated leads to disease. Y39G10AR.22 Y39G10AR.22 Putative ortholog of C. elegans T24A6.5 gene product Y39G10AR.8 Y39G10AR.8 Protein with moderate similarity to C. elegans Y71H2AM.A gene product Y39G10AR.9 Y39G10AR.9 Protein with weak similarity to C. elegans K04G11.4 gene product Y39G10AR.B Y39G10AR.18;Y39G10AR.B Putative ortholog of C. elegans Y39G10AR.19 gene product Y39G10AR.C Y39G10AR.17;Y39G10AR.C Protein of unknown function Y39G10AR.E Y39G10AR.16;Y39G10AR.E Protein with weak similarity to C. elegans Y23H5B.2 gene product Y39G10AR.F Y39G10AR.15;Y39G10AR.F Putative ortholog of C. elegans M117.4 gene product Y39G10AR.M Y39G10AR.11;Y39G10AR.M Protein of unknown function Y39G10AR.Q Y39G10AR.7;Y39G10AR.Q Protein of unknown function Y39G10AR.S Y39G10AR.6;Y39G10AR.S Putative ortholog of C. elegans Y49C4A.8 gene product Y39G10AR.T Y39G10AR.5;Y39G10AR.T Putative ortholog of C. elegans Y39G10A_229.A gene product Y39G10AR.U Y39G10AR.4;Y39G10AR.U Putative ortholog of C. elegans ZC581.1 gene product Y39G10AR.V Y39G10AR.3;Y39G10AR.V Protein of unknown function Y39G10AR.Z Y39G10AR.1;Y39G10AR.Z Protein of unknown function Y39G10A_236.E AF-6;W03F11.6;Y39G10A_236.E Protein containing three PDZ, DHR, or GLGF domains, which are found in signaling proteins, two Ras association (RalGDS or AF6) domains, and two DIL domains, has low similarity to afadin (human MLLT4), which is an intercellular junction protein Y39G10BM.B Y39G10BM.B Protein of unknown function Y39G10BM.C Y39G10BM.C Protein of unknown function Y39G10BM.D Y39G10BM.D Putative paralog of C. elegans AF-6 (Protein that interacts with LET-60 Ras) Y39G10BM.F Y39G10BM.F Protein with weak similarity to C. elegans AF-6 (Protein that interacts with LET-60 Ras) Y39G10BM.G Y39G10BM.G Putative paralog of C. elegans AF-6 (Protein that interacts with LET-60 Ras) Y39G10BR.A Y39G10BR.A Putative paralog of C. elegans AF-6 (Protein that interacts with LET-60 Ras) Y39G8B.1 Y39G8B.1 Protein with high similarity to aldose reductase (aldehyde dehydrogenase, human AKR1B1), which catalyzes the reduction of glucose to sorbitol in the polyol pathway and may be a detoxification enzyme, member of the aldo-keto reductase family Y39G8B.2 Y39G8B.2 Putative paralog of C. elegans Y39G8B.1B Y39G8B.3 Y39G8B.3 Protein of unknown function, putative paralog of C. elegans Y39G8B.4 7TM receptor, sre family Y39G8B.4 Y39G8B.4 Protein of unknown function, putative paralog of C. elegans Y39G8B.3 7TM receptor, sre family Y39G8B.5 Y39G8B.5 Putative paralog of C. elegans R107.4 Y39G8B.7 Y39G8B.7 Protein of unknown function, has strong similarity to C. elegans F01D5.1 Y39G8C.1 Y39G8C.1 Protein with moderate similarity to S. cerevisiae Kem1p, which is a nuclease with 5'-3' exonuclease activity for single-stranded RNA and DNA that primarily degrades decapped mRNA Y39G8C.C Y39G8C.2;Y39G8C.C Protein containing a protein kinase domain, has low similarity to casein kinase 1 alpha 1 (human CSNK1A1), which is a serine/threonine protein kinase that may play a role in Alzheimer's disease Y39H10A.5 Y39H10A.5 Putative ortholog of C. elegans Y39H10A.C gene product Y39H10A.6 Y39H10A.6 Putative ortholog of C. elegans Y39H10A.B gene product Y39H10A.D Y39H10A.4;Y39H10A.D Protein of unknown function Y39H10A.F Y39H10A.3;Y39H10A.F Protein with strong similarity to D. melanogaster CG5026 (CG5026 gene product) Y39H10A.H Y39H10A.2;Y39H10A.H Putative paralog of C. elegans R02C2.3 Y39H10A.I Y39H10A.1;Y39H10A.I Protein of unknown function, has weak similarity to C. elegans R08E5.4 Y39H10A_224.A chk-1;Y39H10A.7;Y39H10A.A;Y39H10A_224.A Protein containing three protein kinase domains, has moderate similarity to human CHEK1, which is a protein kinase required for the DNA damage checkpoint that inhibits mitotic entry after DNA damage via a mechanism that involves the phosphatase CDC25 Y39H10B.A Y39H10B.1;Y39H10B.A Member of the 7-transmembrane chemoreceptor family of G-protein coupled receptors (GPCR), has moderate similarity to C. elegans ODR-10, which is a G protein-coupled receptor involved in odorant response Y40A1A.1 Y40A1A.1 Putative paralog of C. elegans F22H10.5 Y40A1A.2 Y40A1A.2 Protein of unknown function, has strong similarity to C. elegans T02G6.5 Y40A1A.3 Y40A1A.3 Protein of unknown function Y40B10A.1 Y40B10A.1 Putative ortholog of C. elegans Y40B10A_106.C gene product Y40B10A.2 Y40B10A.2 Putative ortholog of C. elegans Y40B10A_107.A gene product Y40B10A.3 Y40B10A.3 Protein with strong similarity to C. elegans C33G8.5 gene product 7TM chemoreceptor, srab family Y40B10A.4 Y40B10A.4 Putative ortholog of C. elegans Y40B10A_112.D gene product Y40B10A.5 Y40B10A.5 Putative ortholog of C. elegans Y40B10A_112.D gene product Y40B10A.6 Y40B10A.6 Putative ortholog of C. elegans Y40B10A_112.C gene product Y40B10A.7 Y40B10A.7 Putative ortholog of C. elegans Y40B10A_112.A gene product Y40B10A.8 Y40B10A.8 Putative ortholog of C. elegans nhr-86 gene product Y40B10A.9 Y40B10A.9 Putative ortholog of C. elegans Y40B10A_106.A gene product Y40B10B.1 Y40B10B.B;Y40B10B.1 Protein of unknown function, has high similarity to uncharacterized C. elegans Y9C9A.1 Y40B10B.A Y40B10B.2;Y40B10B.A Member of the 7-transmembrane chemoreceptor family of G-protein coupled receptors (GPCR), has weak similarity to C. elegans ODR-10, which is a G protein-coupled receptor involved in odorant response Y40B1A.1 Y40B1A.A;Y40B1A.1 Protein of unknown function Y40B1A.2 Y40B1A.B;Y40B1A.2 Protein containing a WW domain, which bind proline-rich peptide epitopes WW domain Y40B1A.D Y40B1A.3;Y40B1A.D Protein of unknown function Y40B1A.E Y40B1A.4;Y40B1A.E Protein containing three C2H2 type zinc finger domain, which bind nucleic acids, has moderate similarity to a region of SP3 transcription factor (human SP3), which regulates gene expression through both transcriptional activation and repression Y40B1B.3 Y40B1B.3 Protein containing an F-box domain, which serve as a link between a target protein and a ubiquitin-conjugating enzyme, has low similarity to uncharacterized C. elegans F09C3.3 This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins. Y40B1B.5 Y40B1B.5 Protein of unknown function Y40B1B.6 Y40B1B.6 Member of the flavin containing amine oxidase family, has moderate similarity to uncharacterized C. elegans T08D10.2 Y40B1B.7 Y40B1B.7 Protein of unknown function Y40B1B.8 Y40B1B.8 Protein of unknown function Y40C5A.1 Y40C5A.1 Protein with weak similarity to H. sapiens Hs.158298 (Human phosphotyrosine independent ligand p62B B-cell isoform for the Lck SH2 domain mRNA, partial cds) Y40C5A.2 Y40C5A.2 Putative ortholog of D. melanogaster CG5842 (CG5842 gene product) ankyrin-like protein Y40C5A.3 Y40C5A.3 Protein with strong similarity to C. elegans ZK546.4 Y40C5A.4 Y40C5A.4 Protein with strong similarity to C. elegans ZK1307.7 Y40C5A.5 Y40C5A.5 Putative paralog of C. elegans T12B3.B Y40C7B.1 Y40C7B.1 Protein of unknown function, has moderate similarity to C. elegans ZC53.4 Y40C7B.2 Y40C7B.2 Putative paralog of C. elegans Y26D4A.11 Y40C7B.3 Y40C7B.3 Protein of unknown function, putative paralog of C. elegans T20F10.4 Y40C7B.4 Y40C7B.4 Protein of unknown function, has moderate similarity to C. elegans Y26D4A.H Y40C7B.5 Y40C7B.5 Protein of unknown function, has weak similarity to C. elegans F35D11.11 Y40D12A.1 Y40D12A.1 Member of the FtsJ-like methyltransferase family, which may bind RNA This gene encodes a protein predicted by Eisenberg and coworkers, with 52% accuracy, to be mitochondrial. Y40D12A.2 Y40D12A.2 Member of the serine carboxypeptidase family, has low similarity to protective protein for beta-galactosidase (cathepsin A, human PPGB), which is a serine carboxypeptidase activity that is associated with galactosialidosis upon gene mutation serine carboxypeptidase Y40D12A.3 Y40D12A.3 Member of the 7-transmembrane chemoreceptor family of G-protein coupled receptors (GPCR), has high similarity to uncharacterized C. elegans Y54G11A.12 7TM chemoreceptor, srh family Y40G12A.1 Y40G12A.1 Putative ortholog of C. elegans F46E10.7 gene product Y40H4A.A Y40H4A.1;Y40H4A.A Member of the rhodopsin family of G protein-coupled receptors (GPCR), has moderate similarity to muscarinic m3 acetylcholine receptor (human CHRM3), which is a G protein-coupled receptor that plays a variety of roles in the nervous system Y40H4A.B Y40H4A.2;Y40H4A.B Member of the protein phosphatase protein family Y40H7.A Y40H7A.1;Y40H7.A Member of the 7-transmembrane chemoreceptor family of G-protein coupled receptors (GPCR), has weak similarity to C. elegans ODR-10, which is a G protein-coupled receptor involved in odorant responser Y40H7.B Y40H7A.3;Y40H7.B Protein of unknown function, has high similarity to uncharacterized C. elegans Y40H7A.2 Y40H7.C Y40H7A.2;Y40H7.C Protein of unknown function, has high similarity to uncharacterized C. elegans Y40H7A.3 Y40H7.F Y40H7A.5;Y40H7.F Protein of unknown function, has high similarity to uncharacterized C. elegans F07C4.5 Y40H7.H Y40H7A.7;Y40H7.H Protein with strong similarity to C. elegans C18H2.1 gene product Y40H7.J Y40H7A.11;Y40H7.J Protein of unknown function, has moderate similarity to uncharacterized C. elegans Y22D7AL.15 Y40H7A.10 Y40H7.I;Y40H7A.10 Member of the papain family of cysteine proteases, has low similarity to cathepsin S (mouse Ctss), which is an endosomal and lysosomal cysteine protease that processes mouse Ii and mediates intracellular trafficking of mouse Ii and MHC class II molecules Cysteine protease Y40H7A.4 Y40H7.E;Y40H7A.4 Protein of unknown function, has high similarity to uncharacterized C. elegans K06H6.2 Y40H7A.6 Y40H7A.6 Putative ortholog of C. elegans Y40H7.G gene product 7TM chemoreceptor, sra family Y40H7A.8 Y40H7A.8 Protein with unknown function Y40H7A.9 Y40H7A.9 Protein with unknown function Cysteine protease Y41C4A.1 Y41C4A.1 Putative ortholog of C. elegans T08B6.5 gene product Y41C4A.10 Y41C4A.10 Elongin B, regulator of RNA polymerase II transcription elongation Y41C4A.11 Y41C4A.11 Protein containing six WD domains (WD-40 repeat), which may mediate protein-protein interactions, has weak similarity to guanine nucleotide-binding protein (G-protein) beta subunit (C. neoformans Gpb1_a), which is involved in signal transduction pathways WD domain, G-beta repeat; Y41C4A.11 encodes a divergent paralog of F38E11.5, the beta' (beta-prime) subunit of the coatomer (COPI) complex; unlike F38E11.5, Y41C4A.11 has no obvious function in mass RNAi assays. Y41C4A.12 Y41C4A.12 Protein of unknown function Y41C4A.13 Y41C4A.13 Protein of unknown function, has moderate similarity to uncharacterized C. elegans F52A8.1 Y41C4A.14 mrt-2;hpr-1;Y41C4A.14 Checkpoint protein required for telomere replication that has strong similarity to human RAD1, an S. pombe exonuclease Rad1p homolog mrt-2 encodes a highly conserved DNA-damage checkpoint protein homologous to the RAD1 protein found in S. pombe, Drosophila, and mammals; MRT-2 interacts with HUS-1 and HPR-9, also conserved DNA-damage checkpoint proteins, and is required in the germline for maintaining chromosomal integrity; mrt-2 mutations result in a failure to induce apoptosis in response to DNA damage, progressive telomere loss, chromosome fusion, and aneuploidy, all leading eventually to germline immortality. Y41C4A.2 Y41C4A.2 Member of the amidase family, which catalyze hydrolysis of amides, has low similarity to fatty acid amide hydrolase (rat Faah), which is a serine hydrolase that degrades neuromodulatory fatty acid amides and terminates their signaling function Y41C4A.3 Y41C4A.3 Protein of unknown function Y41C4A.4 Y41C4A.4 Protein containing two pKID (phosphorylated kinase-inducible) domains, which are involved in transcription regulation, and two bZIP (basic-leucine zipper) transcription factor domains bZIP transcription factor; crh-1 encodes a homolog of the cyclic AMP-response element binding protein (CREB); crh-1 is involved in the transcription of CRE-sequence dependant genes activated by a CaM kinase cascade; crh-1may also be involved in the integration of environmental cues that induce daur formation and may be part of a chemosensory cascade that regulates TGF-beta signaling; CRH-1 is ubiquitously expressed and localizes to nuclei. Y41C4A.5 Y41C4A.5 Protein with strong similarity to C. elegans F40H6.5 gene product The protein product of this gene is predicted to contain a glutamine/asparagine (Q/N)-rich ('prion') domain, by the algorithm of Michelitsch and Weissman (as of the WS77 release of WormBase, i.e., in wormpep77). Y41C4A.6 Y41C4A.6 Protein of unknown function Y41C4A.7 Y41C4A.7 Protein of unknown function Y41C4A.8 Y41C4A.8 Protein of unknown function Y41C4A.9 Y41C4A.9 Protein with strong similarity to S. cerevisiae Yil091p, a protein of unknown function Y41D4A.2 Y41D4A.2 Putative ortholog of C. elegans Y41D4A.G gene product Y41D4A.3 Y41D4A.3 Putative ortholog of C. elegans E04A4.1 gene product Y41D4A.A Y41D4A.8;Y41D4A.A Protein with strong similarity to C. elegans K10C8.2 gene product Y41D4A.B Y41D4A.7;Y41D4A.B Protein of unknown function Y41D4A.C Y41D4A.6;Y41D4A_5905.C;Y41D4A.C Member of the amidase family, which catalyze hydrolysis of amides, has low similarity to S. cerevisiae Ymr293p, which may be involved in mitochondrial function Y41D4A.E Y41D4A.5;Y41D4A.E Protein with strong similarity to C. elegans K04D7.4 gene product Y41D4A.F Y41D4A.4;Y41D4A.F Putative ortholog of C. elegans F08F1.7 gene product Y41D4A_2911.A Y41D4B.10;Y41D4B.S;Y41D4A_2911.A Protein containing a delta serrate ligand (DSL) domain, has a region of low similarity to a region of C. elegans LAG-2, which appears to interact with C. elegans LIN-12 and C. elegans GLP-1 Notch receptors to influence cell fate decisions Y41D4B.13 ced-2;Y41D4A_3457.B;Y41D4B.13 Required for engulfment of cells that have undergone programmed cell death The ced-2 gene encodes a Src homology (SH) 2 and 3-containing adaptor protein, homologous to human CrkII, that is required for phagocytosis during programmed cell death and for migration of the distal tip cells of the somatic gonad; CED-2 functions in the engulfing cell during apoptosis and interacts with CED-5/DOCK180 to activate CED-10/Rac and promote formation of the polarized cell extensions associated with cell corpse engulfment. Y41D4B.19 Y41D4B.19 Putative ortholog of C. elegans Y41D4B.F gene product Y41D4B.20 Y41D4B.20 Putative ortholog of C. elegans nhr-92 gene product Y41D4B.26 Y41D4B.26 Putative ortholog of C. elegans Y41D4B.U gene product Y41D4B.A Y41D4B.24;Y41D4B.A Protein with strong similarity to C. elegans T11F9.1 gene product Y41D4B.AA Y41D4B.1;Y41D4B.AA Protein of unknown function Y41D4B.B Y41D4B.23;Y41D4B.B Protein with moderate similarity to C. elegans Y51F10.4 gene product Y41D4B.C Y41D4B.22;Y41D4B.C Protein of unknown function Y41D4B.D Y41D4B.21;Y41D4B.D Putative ortholog of C. elegans F38H12.3 gene product Y41D4B.J Y41D4B.18;Y41D4B.J Putative ortholog of C. elegans Y41D4B.17 gene product Y41D4B.L Y41D4B.16;Y41D4B.L Putative ortholog of C. elegans Y41D4B.17 gene product Y41D4B.M Y41D4B.15;Y41D4B.M Protein with strong similarity to C. elegans Y51F10.4 gene product Y41D4B.N Y41D4B.14;Y41D4B.N Protein of unknown function Y41D4B.Q Y41D4B.12;Y41D4B.Q Protein with moderate similarity to C. elegans K09F5.5 gene product Y41D4B.R Y41D4B.11;Y41D4B.R Protein with weak similarity to C. elegans F45C12.3 gene product Y41D4B.T Y41D4B.9;Y41D4B.T Putative ortholog of C. elegans nhr-87 gene product Y41D4B.W Y41D4B.5;Y41D4B.W Protein of unknown function Y41D4B.X Y41D4B.4;Y41D4B.X Putative ortholog of C. elegans Y41D4B.3 gene product Y41D4B.Y Y41D4B.3;Y41D4B.Y Putative ortholog of C. elegans Y41D4B.4 gene product Y41D4B_7946.B Y41D4B.17;Y41D4B.K;Y41D4B_7946.B Protein of unknown function, has high similarity to uncharacterized C. elegans Y41D4B.18 Y41D4B_930.B Y41D4B.6;Y41D4B_930.B Putative ortholog of C. elegans Y41D4B.V gene product Y41E3.1 Y41E3.1 Member of uncharacterized DUF229 family, has low similarity to uncharacterized C. elegans F15H10.7 Y41E3.10 Y41E3.10 Protein with high similarity to eukaryotic translation elongation factor 1 delta (human EEF1D), which is a putative component of the a guanine nucleotide exchange protein complex, contains an elongation factor 1 (EF-1) guanine nucleotide exchange domain Elongation factor 1 (beta/delta chain) Y41E3.11 Y41E3.11 Putative E1B-associated protein (GenBank), putative ortholog of H. sapiens Hs.155218 gene product [E1B-55kDa-associated] Y41E3.12 Y41E3.12 Protein containing a DUF32 domain of unknown function, has high similarity to uncharacterized C. elegans M162.3 Y41E3.13 Y41E3.13 Protein of unknown function, has strong similarity to C. elegans F16B12.6 Y41E3.14 Y41E3.14 Protein containing a DUF32 domain of unknown function, has moderate similarity to uncharacterized C. elegans Y41E3.12 Y41E3.15 Y41E3.15 Protein containing a DUF32 domain of unknown function, has high similarity to uncharacterized C. elegans M199.1 Y41E3.16 Y41E3.16 Putative paralog of C. elegans Y53G8AR.D Y41E3.16 encodes an unfamiliar protein with an N-terminal DNA-binding SAP domain and extensive regions of low-complexity sequence, which has no clear homologs outside of nematodes; the Y41E3.16 transcription unit has a natural nonsense transcript that is up-regulated in vivo by smg[-] mutations, indicating that Y41E3.16 is a natural substrate for SMG-mediated nonsense suppresssion; since several other natural mRNA substrates of SMG suppression (e.g., rpl-3, rpl-8, rpl-10a, rpl-12) have protein products that are involved in translation, Y41E3.16 protein may function in translation as well. Y41E3.2 Y41E3.2 Protein with high similarity to C. elegans SQT-3, which is a collagen, contains two collagen triple helix repeats, which are found in some extracellular proteins, and a nematode cuticle collagen N-terminal domain CUTICLE COLLAGEN 1; dpy-4 is an uncloned gene required for normal body length; dpy-4 was first identified with the mutagen ICR. Y41E3.3 Y41E3.3 Protein of unknown function, has moderate similarity to uncharacterized human LOC51062 Y41E3.4 Y41E3.4 Protein with high similarity to glutaminyl-tRNA synthetase (human QARS), which aminoacylates cognate tRNAs with glutamine for protein biosynthesis, member of the class I glutamyl and glutaminyl (E and Q) tRNA synthetase family tRNA synthetases class I (E and Q); ers-1 encodes a glutaminyl (Q) tRNA synthetase that affects growth and embryonic and larval viability in large-scale RNAi screens; it is predicted to be mitochondrial. Y41E3.5 Y41E3.5 Protein of unknown function, has weak similarity to C. elegans R102.1 Y41E3.6 Y41E3.6 Member of an uncharacterized protein family Y41E3.7 Y41E3.7 Protein with moderate similarity to peripheral benzodiazepine receptor associated protein (mouse Pap7), which binds peripheral-type benzodiazepine receptor (mouse Bzrp) and mouse Prkar1a and regulates the hormone-induced signal transduction cascade Y41E3.8 Y41E3.8 Protein of unknown function Y41E3.9 Y41E3.9 Protein of unknown function The Y41E3.9 gene encodes an ortholog of the human gene FANCD2, which when mutated leads to one variety of Fanconi anemia (complementation group D2, FA-D2; OMIM:227646). Y41G9A.1 osm-5;Y41G9A.1 Involved in neuronal development and osmotic avoidance The osm-5 gene encodes a homolog of the murine cystic kidney disease gene Tg737 that is required for the production of cilia in sensory neurons. Y41G9A.2 Y41G9A.2 Protein of unknown function, has weak similarity to C. elegans ZK816.4; may be anchored to the membrane of a secretory vesicle or the Golgi apparatus Y41G9A.3 Y41G9A.3 Protein with strong similarity to H. sapiens PRKAG1 (protein kinase, AMP-activated, gamma 1 non-catalytic subunit) protein kinase Y41G9A.4 Y41G9A.4 Putative ortholog of H. sapiens GABBR1 (gamma-aminobutyric acid (GABA) B receptor, 1) glutamate receptor Y41G9A.6 Y41G9A.6 Protein of unknown function Y41G9A.8 Y41G9A.8 Protein with moderate similarity to C. elegans ZK180.1 gene product Y41G9A.B Y41G9A.5;Y41G9A.B Protein of unknown function Y42A5A.1 Y42A5A.1 Member of the M1 peptidase family of aminopeptidases, has low similarity to aminopeptidase N (aminopeptidase M, rat APN), which is a zinc metallopeptidase involved in degradation of regulatory peptides that converts angiotensin III (Agt) to angiotensin IV Zinc-binding metalloprotease domain Y42A5A.2 Y42A5A.2 Protein of unknown function, has moderate similarity to C. elegans C40H5.4 Y42A5A.3 Y42A5A.3 Protein of unknown function Y42A5A.4 Y42A5A.4 Protein with strong similarity to human KKIALRE protein, a serine/threonine protein kinase Eukaryotic protein kinase domain Y42G9A.1 Y42G9A.1 Protein of unknown function, has weak similarity to C. elegans Y42G9A_141.F Y42G9A.2 Y42G9A.2 Protein of unknown function Y42G9A.3 Y42G9A_141.D;Y42G9A.D;Y42G9A.3 Protein containing seven leucine rich repeats, which mediate protein-protein interactions, has a region of low similarity to ras suppressor 1 (human RSU1), which is a leucine-rich protein that reduces the oncogenic potential of glioblastoma cells Y42G9A.4 Y42G9A.4 Putative paralog of C. elegans Y42G9A_141.C The Y42G9A.4 gene encodes an ortholog of the human gene MEVALONATE KINASE (MVK), which when mutated leads to mevalonicaciduria (OMIM:251170). Y42G9A.5 Y42G9A_141.B;Y42G9A.B;Y42G9A.5 Member of the ABC transporter family, has low similarity to ATP-binding cassette subfamily G member 2 (breast cancer resistance protein, mouse Abcg2), which is a phospholipid and cholesterol transporter involved in the development of multidrug resistance Y42G9A.6 Y42G9A_141.A;Y42G9A.A;Y42G9A.6 Protein with moderate similarity to C. elegans C10C6.5 gene product Y42H9AR.3 Y42H9AR.3 Putative ortholog of C. elegans Y42H9AR.D gene product Y42H9AR.5 Y42H9AR.5 Protein of unknown function Y42H9AR.C Y42H9AR.4;Y42H9AR.C Protein of unknown function Y42H9AR.E Y42H9AR.2;Y42H9AR.E Protein with strong similarity to C. elegans F40F9.2 Y42H9AR.F Y42H9AR.1;Y42H9AR.F Protein with strong similarity to D. melanogaster CG7809 (CG7809 gene product) Y42H9B.A Y42H9B.3;Y42H9B.A Protein of unknown function Y42H9B.B Y42H9B.2;Y42H9B.B Putative ortholog of D. melanogaster sdk (sidekick) Y42H9B.C Y42H9B.1;Y42H9B.C Protein with strong similarity to C. elegans F38A3.1 (Putative collagen, protein with strong similarity to human COL5A2 protein, alpha-2 collagen, type V) Y43B11AL.1 Y43B11AL.1 Protein with strong similarity to C. elegans F59B2.8 gene product Y43B11AL.2 Y43B11AL.2 Putative paralog of C. elegans T10H4.9 7TM chemoreceptor, srx family Y43B11AL.3 Y43B11AL.3 Protein of unknown function, has weak similarity to C. elegans F18E3.5 Y43B11AR.B Y43B11AR.4;Y43B11AR.B Putative ortholog of S. cerevisiae RPS4B or RPS4A gene products (Ribosomal protein S4 (yeast S7) Y43B11AR.C Y43B11AR.3;Y43B11AR.C Protein with weak similarity to H. sapiens CLONE24922 (hypothetical protein) Y43B11AR.D Y43B11AR.2;Y43B11AR.D Protein of unknown function, has weak similarity to C. elegans T02B11.1 Y43B11AR.E Y43B11AR.1;Y43B11AR.E Protein of unknown function Y43C5A.1 Y43C5A.1 Protein of unknown function Y43C5A.2 Y43C5A.2 Protein containing a beta or gamma fibrinogen C-terminal globular domain, has low similarity to a region of angiopoietin 2 (mouse Agpt2), which is an antagonist of mouse Agpt1 and inhibits Agpt1-induced angiogenesis Fibrinogen beta and gamma chains, C-terminal globular domain Y43C5A.3 Y43C5A.3 Protein of unknown function Y43C5A.4 Y43C5A.4 Protein of unknown function Y43C5A.5 Y43C5A.5 Protein with high similarity to thymidine kinase 1 (human TK1), which is a cytosolic enzyme that generates thymidylate for DNA synthesis and activates nucleoside analog antiviral and anticancer drugs, member of the thymidine kinase family thymidine kinases Y43C5A.6 rad-51;rad51;rdh-1;RDH1;DMC1-LIM15;Y43C5A.6 Member of the RecA-like protein family, required for meiosis Helix-hairpin-helix motif.; rad-51 encodes two isoforms of a protein orthologous to S. cerevisiae Rad51p and Dmc1p, and to E. coli RecA, and paralogous to C30A5.2; RAD-51 proteins are probably required for meiotic recombination; while dispensable for viability and meiotic synapsis, RAD-51A/B are required for normal chromosomal morphology, univalent formation, dissociation of chiasmata, hyperresistance of meiotic pachytene nuclei to X-irradiation, and the progress of oocytes through diakinesis; RAD-51A/B require CHK-2, MRE-11, and SPO-11 to localize to foci in late zygotene/early pachytene nuclei, and genetically acts downstream of CHK-2 and SPO-11; RAD-51A/B foci later disappear from homologously synapsed chromosomes. Y43C5B.2 Y43C5B.2 Protein containing a Src homology 2 (SH2) domain, which are regulatory modules of intracellular signaling, and a protein kinase domain, has low similarity to a region of Fes related tyrosine kinase (human FER), which may mediate cell signaling Src homology domain 2, tyrosine-protein kinase Y43C5B.3 Y43C5B.3 Member of the mitochondrial carrier protein family of membrane transporters, has moderate similarity to uncharacterized C. elegans F13G3.7 Mitochondrial carrier proteins (2 domains) Y43D4A.1 Y43D4A.B;Y43D4A.1 Protein with strong similarity to C. elegans C49C3.1 gene product Y43D4A.2 Y43D4A.C;Y43D4A.2 Putative ortholog of C. elegans C08F11.8 gene product Y43D4A.4 Y43D4A.E;Y43D4A.4 Putative ortholog of C. elegans C27A7.6 gene product Y43D4A.5 Y43D4A.F;Y43D4A.5 Protein with moderate similarity to C. elegans F09B12.1 gene product Y43D4A.6 Y43D4A.G;Y43D4A.6 Putative ortholog of C. elegans chk-1 gene product Y43D4A.7 Y43D4A.7 Protein with strong similarity to C. elegans C27A7.1 gene product Y43D4A.D Y43D4A.3;Y43D4A.D Putative ortholog of C. elegans C27A7.6 gene product Y43E12A.1 Y43E12A.1 Protein containing cyclin N-terminal and C-terminal domains, which often form complexes with protein kinases and cyclin dependent protein kinases, has low similarity to a region of cyclin B1 (human CCNB1), which helps to mediate G2-M phase transition cyclin B Y43E12A.2 Y43E12A.2 Protein of unknown function Y43E12A.3 Y43E12A.3 Protein containing a BTB (BR-C, ttk and babor) or POZ (Pox virus and zinc finger) domain, which are found in some DNA and actin binding proteins and may mediate protein-protein interactions, has high similarity to uncharacterized C. elegans H31G24.3 BTB (also known as BR-C/Ttk) domain. Y43F11.D Y43F11A.1;Y43F11A.4;Y43F11.D Protein of unknown function, has moderate similarity to uncharacterized C. elegans Y57A10A.Y Y43F11A.2 Y43F11.B;Y43F11A.2 Protein of unknown function, has moderate similarity to C. elegans F56C9.2 Y43F11A.3 Y43F11A.3 Protein of unknown function, has weak similarity to C. elegans Y57A10A.1 Y43F11A.5 Y43F11A.5 Protein of unknown function, putative paralog of C. elegans Y43F11.E Y43F11A.6 Y43F11A.6 Protein with strong similarity to C. elegans Y53C10A.1 gene product Y43F4A.1 Y43F4A.1 Member of the metallopeptidase M8 family, has moderate similarity to uncharacterized human LMLN zinc metallopeptidase (M8 family) Y43F4A.2 Y43F4A.2 Member of the reverse transcriptase protein family, which are RNA-dependent DNA polymerases, contains a retroviral integrase core domain, which can act as endonucleases, has strong similarity to uncharacterized C. elegans F07B7.6 Reverse transcriptase (RNA-dependent DNA polymerase) Y43F4A.3 Y43F4A.3 Protein with strong similarity to C. elegans W09B7.C Y43F4A.4 Y43F4A.4 Protein of unknown function, has a region of high similarity to a region of branched-chain alpha-keto acid dehydrogenase E1 alpha subunit (human BCKDHA), which catalyzes mitochondrial oxidative decarboxylation of leucine, isoleucine, and valine Y43F4B.1 Y43F4B.1 Protein of unknown function, contains a putative SET domain, has weak similarity to human G9A (Hs.75196) of the major histocompatibility complex Y43F4B.2 Y43F4B.2 Putative ubiquitin carboxyl-terminal hydrolase Y43F4B.3 Y43F4B.3 Protein of unknown function Y43F4B.4 Y43F4B.4 Protein containing four WD domains (WD-40 repeat), which may mediate protein-protein interactions, has low similarity to S. cerevisiae Seh1p, which forms a complex with nuclear pore proteins WD domain, G-beta repeat (2 domains) Y43F4B.5 Y43F4B.5 Protein containing phosphoglucomutase or phosphomannomutase alpha-beta-alpha domains I and II, has high similarity to uncharacterized human FLJ10983 Phosphoglucomutase and phosphomannomutase phosphoserine Y43F4B.6 Y43F4B.6 Putative kinesin-like protein, protein has strong similarity to human KNSL1 and D. melanogaster Klp61F kinesin-like proteins Kinesin motor domain; klp-19 encodes a plus-end-directed microtubule motor protein that is most closely related to motors of the kinesin-4 family; KLP-19 activity is essential for embryonic and larval development and is required for generating a force that aligns sister chromatid kinetochores directly opposite the spindle poles thus ensuring proper holocentric chromosome segregation; KLP-19 expression is detected in embryos and in the gonad, where it is most strongly expressed in distal mitotic nuclei and in late meiotic prophase nucleoplasm; during meiosis and mitosis, KLP-19 expression is dynamic and is detected in the nucleoplasm, the spindle body, in association with condensed chromosomes (particularly between homologous chromosomes), and in the spindle interzone. Y43F4B.7 Y43F4B.7 Member of the transmembrane amino acid transporter (permease) family, has low similarity to lysosomal amino acid transporter 1 (rat Lyaat1), which transports small neutral amino acids and some neurotransmitters Y43F4B.8 Y43F4B.8 Protein of unknown function, has strong similarity to C. elegans R11E3.3 Y43F4B.9 Y43F4B.9 Protein of unknown function Y43F8A.3 Y43F8A.C;Y43F8A.3 Protein with low similarity to arylacetamide deacetylase (human AADAC), which is an esterase involved in the metabolic activation of arylamine carcinogens Y43F8A.A Y43F8A.1;Y116F11A.L;Y43F8A.A Protein with strong similarity to C. elegans Y116F11.O gene product Y43F8A.B Y43F8A.2;Y43F8A.B Protein of unknown function, has low similarity to uncharacterized C. elegans F31E8.5 Y43F8A.D Y43F8A.4;Y43F8A.D Protein of unknown function, has low similarity to uncharacterized C. elegans K04F1.3 Y43F8A.E Y43F8A.5;Y43F8A.E Protein of unknown function, has weak similarity to uncharacterized C. elegans Y4C6B.5 Y43F8B.10 Y43F8B.D;Y43F8B.10 Protein of unknown function Y43F8B.11 Y43F8B.C;Y43F8B.11 Protein with moderate similarity to C. elegans K09H9.5 gene product Y43F8B.12 Y43F8B.12 Protein with strong similarity to C. elegans C25F9.5 gene product Y43F8B.13 Y43F8B.B;Y43F8B.13 Protein with strong similarity to C. elegans C25F9.9 gene product Y43F8B.2 Y43F8B.2 Putative ortholog of C. elegans Y43F8B.M gene product Y43F8B.7 Y43F8B.7 Protein with strong similarity to C. elegans W04A8.4 gene product Y43F8B.A Y43F8B.14;Y43F8B.A Protein of unknown function, has moderate similarity to uncharacterized C. elegans M04C3.1 Y43F8B.E Y43F8B.9;Y43F8B.E Protein with strong similarity to C. elegans Y43F8B.F gene product Y43F8B.J Y43F8B.3;Y43F8B.J Protein containing sixteen kunitz or bovine pancreatic trypsin inhibitor domains, has a region of low similarity to tissue factor pathway inhibitor (human TFPI), which is a protease inhibitor that inhibits fibrin clot formation Y43F8B.P Y43F8B.1;Y43F8B.P Protein with strong similarity to C. elegans Y43F8B.O gene product Y43F8B.R B0399.2;Y43F8B.R Protein containing a DUF33 domain of unknown function, has high similarity to uncharacterized C. elegans F11A5.8 Y43F8C.1 Y43F8C.1 YGGWamide neurotransmitter Y43F8C.10 Y43F8C.10 Protein containing a putative DM (dsx, mab-3) DNA-binding domain DM DNA binding domain Y43F8C.11 Y43F8C.11 Protein of unknown function Y43F8C.12 Y43F8C.12 ABC transporter transmembrane region ABC transporter; mrp-7 encodes a predicted ATP-binding cassette (ABC) transporter that is a member of the ABCC subfamily of ABC transporters that includes the multidrug resistance-associated proteins and the cystic fibrosis transmembrane conductance regulator; by homology, MRP-7 is predicted to function as an ATP-dependent organic anion transporter that transports molecules across the plasma membrane into the extracellular space; at present, the precise role of MRP-7 in C. elegans development and/or behavior is not yet known. Y43F8C.13 Y43F8C.13 Protein of unknown function, similar to (inosine-uridine)IU-Nucleoside hydrolase Inosine-uridine preferring nucleoside hydrolase Y43F8C.14 Y43F8C.14 Protein of unknown function, contains putative (pleckstrin homology)PH-domain PH (pleckstrin homology) domain Y43F8C.15 Y43F8C.15 Protein of unknown function Y43F8C.16 Y43F8C.16 Protein of unknown function Y43F8C.17 Y43F8C.17 Protein of unknown function Y43F8C.2 Y43F8C.2 Neuropeptide neurotransmitter nlp-26 encodes a predicted neuropeptide not found in multigene families within C. elegans and is not clearly related to other well-characterized neuropeptides. Y43F8C.3 Y43F8C.3 Protein with weak similarity to C. elegans C08E3.2 gene product Y43F8C.4 Y43F8C.4 Protein of unknown function Y43F8C.5 Y43F8C.5 Protein with moderate similarity to C. elegans Y53G8AR.H gene product Y43F8C.6 Y43F8C.6 Possible mitochondrial ribosomal small subunit protein Y43F8C.7 Y43F8C.7 Protein of unknown function Y43F8C.8 Y43F8C.8 Possible mitochondrial small subunit protein Y43F8C.9 Y43F8C.9 Protein of unknown function, predicted to contain a glycosylphosphatidylinositol (GPI) lipid anchor Y43H11AL.3 Y43H11AL.3 Putative ortholog of C. elegans Y43H11AL.A gene product The protein product of this gene is predicted to contain a glutamine/asparagine (Q/N)-rich ('prion') domain, by the algorithm of Michelitsch and Weissman (as of the WS77 release of WormBase, i.e., in wormpep77). Y43H11AL.C Y43H11AL.2;Y43H11AL.C Protein with moderate similarity to S. cerevisiae YBR147W Y43H11AL.D Y43H11AL.1;Y43H11AL.D Protein of unknown function, has weak similarity to C. elegans Y51H1A.4 Y44A6B.1 Y44A6B.1 Member of an uncharacterized protein family Y44A6B.2 Y44A6B.2 Protein of unknown function, has moderate similarity to C. elegans Y44A6B.1 Y44A6B.3 Y44A6B.3 Protein of unknown function, has moderate similarity to uncharacterized C. elegans Y39A3A.2 Y44A6B.4 Y44A6B.4 Member of the transthyretin-like family Transthyretin-like family Y44A6C.1 Y44A6C.1 Protein of unknown function Y44A6C.2 Y44A6C.2 Protein of unknown function, has moderate similarity to uncharacterized C. elegans F31E9.4 Y44A6D.1 Y44A6D.1 Protein of unknown function, has weak similarity to C. elegans W04G5.3 Y44A6D.2 Y44A6D.2 Protein of unknown function Y44A6D.3 Y44A6D.3 Protein of unknown function Y44A6D.4 Y44A6D.4 Member of the transthyretin-like family, has low similarity to a region of protein tyrosine phosphatase receptor type alpha (human PTPRA), which is a putative receptor tyrosine phosphatase that negatively regulates proliferation and inhibits tumor growth Protein-tyrosine phosphatase; sdf-9 encodes a protein tyrosine phosphatase homolog, paralogous to F10G8.4; SDF-9 is required for a correct L3/dauer developmental decision, and that may promote DAF-9 activity by means of steroid hormone signalling; sdf-9 dauer larvae resemble those of daf-9 and daf-12 dauer-constitutive mutants, and these Daf-c mutants are all enhanced by cholesterol deprivation; SDF-9 is expressed in embryonic hypodermal cells (XXXL/R) whose ablation in wild-type L1 larvae also causes daf-9-like pseudodauer larvae. Y44A6D.5 Y44A6D.5 Protein with high similarity to cytosolic branched-chain amino acid aminotransferase (rat Bcat1), which reveribly transaminates branched-chain L-amino acids, member of the aminotransferases class IV family of pyridoxal-dependent enzymes Aminotransferase class IV; This gene encodes a protein predicted by Eisenberg and coworkers, with 52% accuracy, to be mitochondrial. Y44A6D.6 Y44A6D.6 Protein of unknown function Y44A6E.A Y44A6E.1;Y44A6E.A Protein containing a neurotransmitter-gated ion-channel ligand binding domain, has weak similarity to 5-hydroxytryptamine 3B (serotonin) receptor subunit (human HTR3B), which forms heteromers with human HTR3A that exhibit serotonin-induced conductance Y44E3A.1 Y44E3A.G;Y44E3A.1 Protein of unknown function Y44E3A.2 ace-2;Y44E3A.2 Type H, I acetylcholinesterase carboxylesterase; An acetylcholineesterase involved in the termination of cholinergic nerve transmission; it is predominantly expressed in motoneurons. Y44E3A.3 Y44E3A.E;Y44E3A.3 Member of the thioredoxin family, which are small enzymes involved in redox reactions, has moderate similarity to thioredoxin (human TXN), which has dithiol-disulfide oxidoreductase activity This gene encodes a protein predicted by Eisenberg and coworkers, with 52% accuracy, to be mitochondrial. Y44E3A.4 Y44E3A.4 Protein of unknown function Y44E3A.A Y44E3A.6;Y44E3A.A Putative ortholog of C. elegans Y44E3A.C gene product Y44E3A.D Y44E3A.5;Y44E3A.D Protein containing two Src homology 3 (SH3) domains, which bind proline-rich peptides, has low similarity to a region of c-Cbl-interacting protein (human SH3KBP1), which is an SH3 domain adaptor protein that interacts with human CBL and human BLNK Y44E3B.1 Y44E3B.1 Protein of unknown function, has high similarity to uncharacterized C. elegans D1005.3 Y44E3B.2 Y44E3B.2 Protein containing a tyrosinase central domain, which are copper-binding domains tyrosinase Y44F5A.1 Y44F5A.1;3E324 Protein containing five WD domains (WD-40 repeat), which may mediate protein-protein interactions Y45F10A.1 Y45F10A.1 Protein of unknown function Y45F10A.2 Y45F10A.2 Protein containing eight Pumilio-family (Puf) RNA binding domains, has high similarity to a region of C. elegans FBF-1, which is an RNA-binding protein involved in sex determination Pumilio-family RNA binding domains (aka PUM-HD, Pumilio homology domain); The puf-3 gene encodes a predicted RNA binding protein that is a member of the conserved PUF (Pumilio and FBF) family of RNA binding proteins; PUF-3 is expressed in the ovary and is required for multiple aspects of early embryogenesis including proper cell cycle timing, spindle positioning, and formation of the polar bodies and pronuclei. Y45F10A.3 Y45F10A.3 Protein of unknown function, has moderate similarity to uncharacterized C. elegans D2024.2 Y45F10A.4 Y45F10A.4 Protein with high similarity to selenophosphate synthetase 1 (human SPS), which produces monoselenophosphate from ATP plus selenide and is important in incorporation of selenocysteine in proteins, contains AIR synthase N-terminal and C-terminal domains AIR synthase related proteins Y45F10A.5 Y45F10A.5 MRxamide neurotransmitter Y45F10A.6 Y45F10A.6 Protein with strong similarity to Rab-GAP protein Probable rabGAP domains Y45F10A.7 Y45F10A.7 Protein of unknown function Y45F10A.8 Y45F10A.8 Protein of unknown function Y45F10B.1 Y45F10B.1 Member of the tetraspanin family, has weak similarity to the CD53 antigen (mouse Cd53), which is a pan-leukocyte cell surface antigen that is induced upon T-cell stimulation and may have an anti-apoptotic function tetraspanin Y45F10B.10 Y45F10B.10 Protein containing twelve WD domains (WD-40 repeat), which may mediate protein-protein interactions, has a region of weak similarity to a region of apoptotic protease activating factor 1 (human APAF1), which promotes a mitochondrial apoptotic pathway WD domain, G-beta repeat (4 domains); The qui-1 gene encodes a protein of unknown function that contains several WD-40 domains. Y45F10B.11 Y45F10B.11 Protein containing a DUF215 domain of unknown function, has high similarity to uncharacterized C. elegans Y45F10B.5 Y45F10B.12 Y45F10B.12 Protein of unknown function, has low similarity to uncharacterized C. elegans Y73E7A.5 Y45F10B.13 Y45F10B.13 Putative ortholog of C. elegans F52G2.4 gene product Y45F10B.14 srd-10;Y45F10B.14 Protein of unknown function, has strong similarity to C. elegans C39H7.6 7TM chemoreceptor (srd-family) Y45F10B.2 Y45F10B.2 Protein of unknown function, has strong similarity to uncharacterized C. elegans F37A8.2 Y45F10B.3 Y45F10B.3 Protein of unknown function, has very strong similarity to uncharacterized C. elegans C47A4.5 Y45F10B.4 Y45F10B.4 Protein containing a DUF215 domain of unknown function, has high similarity to uncharacterized C. elegans T04A11.10 Y45F10B.5 Y45F10B.5 Protein containing a DUF215 domain of unknown function, has high similarity to uncharacterized C. elegans F53B2.4 Y45F10B.6 Y45F10B.6 Protein containing a DUF215 domain of unknown function, has high similarity to uncharacterized C. elegans Y45F10B.5 Y45F10B.8 Y45F10B.8 Protein containing a C3HC4 type (RING) zinc finger, which may mediate protein-protein interactions, has very strong similarity to uncharacterized C. elegans Y45F10B.9 Zinc finger, C3HC4 type (RING finger) Y45F10B.9 Y45F10B.9 Protein containing a C3HC4 type (RING) zinc finger, which may mediate protein-protein interactions, has very strong similarity to uncharacterized C. elegans Y45F10B.8 Zinc finger, C3HC4 type (RING finger) Y45F10C.1 Y45F10C.1 Member of a protein family, putative paralog of C. elegans B0513.6 Y45F10C.2 Y45F10C.2 Protein of unknown function, has strong similarity to C. elegans C08F11.12 Y45F10C.3 Y45F10C.3 Protein containing an F-box domain, which serve as a link between a target protein and a ubiquitin-conjugating enzyme, and a DUF38 domain of unknown function, has a region of low similarity to C. elegans FOG-2, which is required for germ cell identity This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins; this gene's encoded protein also contains an FTH/DUF38 motif, which may also mediate protein-protein interaction. Y45F10C.4 Y45F10C.4 Protein of unknown function, has weak similarity to C. elegans C08F11.11 Y45F10C.5 Y45F10C.5 Member of the transposase protein family, putative paralog of C. elegans B0513.7 protein HYPOTHETICAL 29.3 KD PROTEIN B0280.6 IN CHROMOSOME III Y45F10D.1 Y45F10D.1 Member of the Tc3 Transposase protein family Y45F10D.10 Y45F10D.10 Protein of unknown function Y45F10D.11 Y45F10D.11 Possible mitochondrial large subunit protein This gene encodes a protein predicted by Eisenberg and coworkers, with 52% accuracy, to be mitochondrial. Y45F10D.12 Y45F10D.12 Protein with high similarity to ribosomal protein L18 (human RPL18), which is a negative regulator of double-stranded RNA-activated protein kinase, member of the eukaryotic ribosomal protein L18 family, which are part of the large ribosomal subunit Eukaryotic ribosomal protein L18; rpl-18 encodes a large ribosomal subunit L18 protein. Y45F10D.13 Y45F10D.13 Protein containing three Src homology 3 (SH3) domains, which bind proline-rich peptides, has low similarity to beta vinexin (SH3-containing adaptor molecule-1, human SCAM-1), which binds vinculin (human VCL) and may affect cell adhesion Src homology domain 3 (3 domains) Y45F10D.2 Y45F10D.2 Protein of unknown function Y45F10D.3 Y45F10D.3 Member of the glycosyl transferase family 2, contains a QXW (ricin B) lectin repeat domain, which may bind simple sugars, has moderate similarity to N-acetylgalactosaminyltransferase T1 (human GALNT1), which initiates O-glycosylation Glycosyl transferases Y45F10D.4 Y45F10D.4 Protein with high similarity to nitrogen fixation cluster protein (human NIFU), which is an iron-binding protein that appears to be involved in the assembly and compartmentalization of Fe-S clusters, contains a NifU-like N terminal domain This gene encodes a protein predicted by Eisenberg and coworkers, with 52% accuracy, to be mitochondrial. Y45F10D.6 Y45F10D.6 Protein of unknown function, has weak similarity to C. elegans R05A10.1 Y45F10D.7 Y45F10D.7 Protein containing a WD domain (WD-40 repeat), which may mediate protein-protein interactions, has low similarity to uncharacterized beta transducin (S. pombe Spcc1672.07p) Y45F10D.9 Y45F10D.9 Putative coiled-coil protein, has weak similarity to human CENPE and S. cerevisiae Uso1p sas-6 encodes a protein that contains a coiled-coil region and a novel PISA (present in SAS-6) motif which is conserved in similar proteins in at least eight other species that contain basal bodies or centrioles; SAS-6 activity, along with that of ZYG-1, SAS-4, SAS-5, and SPD-2, is essential for centriole duplication; SAS-6 functions in a dose-dependent manner and localizes to centriolar cylinders; SAS-6 co-localizes to centrioles with SAS-4 and SAS-5, and is mutually dependent upon SAS-5, with which it interacts physically, for centriolar localization; SAS-6 localization also requires the activity of the ZYG-1 kinase; in addition to the early embryo, SAS-6 is also detected in sperm. Y45F3A.1 Y45F3A.1 Protein with weak similarity to C. elegans nmy-2 (Nonmuscle myosin II heavy chain-related protein required for cytokinesis and establishment of early embryonic polarity) Y45F3A.2 Y45F3A.2 Protein with high similarity to S. cerevisiae Ypt1p, which is a GTP-binding protein required for vesicle transport from ER to Golgi and within the Golgi stack, member of the Ras superfamily of GTP-binding proteins Ras family; rab-30 encodes a rab related protein of the Ras GTPase superfamily. Y45F3A.3 Y45F3A.3 Protein containing acyl-CoA dehydrogenase middle and C-terminal domains, has weak similarity to rat Acadvl, which is a very-long-chain acyl-coenzyme A dehydrogenase Acyl-CoA dehydrogenase Y45F3A.4 Y45F3A.4 Protein of unknown function Y45F3A.5 Y45F3A.5 Protein of unknown function Y45F3A.8 Y45F3A.8 Protein containing a DUF18 domain of unknown function, has low similarity to uncharacterized C. elegans T05B4.11 Y45F3A.9 Y45F3A.9 Member of the RNA methyltransferase family, which may be 2'-O-methyltransferases, has low similarity to S. cerevisiae Pet56p, which is a ribose methyltransferase specific for G2270 in mitochondrial 21S rRNA SpoU rRNA Methylase family; This gene encodes a protein predicted by Eisenberg and coworkers, with 52% accuracy, to be mitochondrial. Y45G12A.A Y45G12A.1;Y45G12A.A Member of the 7-transmembrane chemoreceptor family of G protein-coupled receptors (GPCR), has high similarity to uncharacterized C. elegans T03D3.14 Y45G12B.1 Y45G12B.1 Putative NADH-Ubiquinone reductase NADH-ubiquinone reductase; Y45G12B.1 is orthologous to human NADH-UBIQUINONE OXIDOREDUCTASE Fe-S PROTEIN 1 (NDUFS1; OMIM:157655), which when mutated leads to mitochondrial complex I deficiency. Y45G12B.2 Y45G12B.2 Protein of unknown function Y45G12B.3 Y45G12B.3 Protein of unknown function Y45G12C.15 srj-20;Y45G12C.15 Putative chemoreceptor 7TM chemoreceptor, srj family Y45G12C.5 Y45G12C.5 Putative chemoreceptor 7TM chemoreceptor, srt family Y45G12C.6 Y45G12C.6 Putative chemoreceptor chemoreceptor Y45G12C.7 Y45G12C.7 Protein of unknown function, putative paralog of C. elegans Y45G12C.I 7TM chemoreceptor, srd family Y45G12C.8 Y45G12C.8 Putative ortholog of C. elegans T05G11.2 gene product Y45G12C.C srj-19;Y45G12C.14;Y45G12C.C Member of the 7-transmembrane chemoreceptor family of G-protein coupled receptors (GPCR), has weak similarity to C. elegans ODR-10, which is a G protein-coupled receptor involved in odorant response Y45G12C.D Y45G12C.13;Y45G12C.D Member of the transposase family, which are required for excising and inserting mobile genetic elements, has very strong similarity to uncharacterized C. elegans F27B3.4 Y45G12C.E str-154;Y45G12C.12;Y45G12C.E Member of the 7-transmembrane chemoreceptor family of G-protein coupled receptors (GPCR), has low similarity to C. elegans ODR-10, which is a G protein-coupled receptor involved in odorant response Y45G12C.F Y45G12C.11;Y45G12C.F Protein of unknown function, has very strong similarity to uncharacterized C. elegans F56A4.6 Y45G12C.G Y45G12C.10;Y45G12C.G Member of the 7-transmembrane chemoreceptor family of G-protein coupled receptors (GPCR), has a region of low similarity to C. elegans ODR-10, which is a G protein-coupled receptor involved in odorant response Y45G12C.H Y45G12C.9;Y45G12C.H Protein of unknown function, has low similarity to uncharacterized C. elegans F15A2.4 Y45G12C.K Y45G12C.4;Y45G12C.K Protein containing a DUF 227 domain of unknown function, has very strong similarity to uncharacterized C. elegans F56A4.5 Y45G12C.M Y45G12C.2;Y45G12C.M Protein containing glutathione S-transferase N-terminal and C-terminal domains, has moderate similarity to glutathione S-transferase pi (human GSTP1), which is involved in carcinogen detoxification and protection against reactive oxygen species Y45G12C.N Y45G12C.1;Y45G12C.N Protein containing a DUF235 domain of unknown function, has high similarity to uncharacterized C. elegans C06B8.2 Y45G5AL.1 Y45G5AL.1 Putative ortholog of C. elegans Y45G5AM.E gene product Y45G5AM.1 Y45G5AM.1 Putative ortholog of C. elegans H12C20.3 gene product nhr-114 encodes, by alternative splicing, two isoforms of a nuclear hormone receptor that specifically binds GPA-13 in yeast two-hybrid assays; the interaction of NHR-114 with GPA-13 is independent of whether GPA-13 is constitutively activated or not; NHR-114 is expressed in intestine (and weakly in hypodermal cells), with mainly nuclear localization; NHR-114 has no obvious function or phenotype in RNAi assays. Y45G5AM.2 Y45G5AM.2 Putative ortholog of C. elegans W03G9.4 gene product Y45G5AM.3 Y45G5AM.3 Putative ortholog of C. elegans F25E5.5 gene product Y45G5AM.4 Y45G5AM.4 Protein with moderate similarity to C. elegans Y45G5AM.5 gene product Y45G5AM.5 Y45G5AM.5 Protein with moderate similarity to C. elegans Y45G5AM.4 gene product Y45G5AM.6 Y45G5AM.6 Putative ortholog of C. elegans Y45G5AM.D gene product Y45G5AM.7 Y45G5AM.7 Protein with strong similarity to C. elegans Y45G5AM.B gene product Y45G5AM.8 Y45G5AM.8 Putative ortholog of C. elegans coh-3 gene product Y45G5AM.9 Y45G5AM.9 Protein with strong similarity to C. elegans Y45G5AR.1 gene product Y45G5AR.A Y45G5AR.1;Y45G5AR.A Protein with strong similarity to C. elegans Y45G5AM.9 gene product Y46B2A.3 Y46B2_176.A;Y46B2A.A;Y46B2A.3 Protein with strong similarity to C. elegans T02H6.3 gene product Y46B2A.C C11E4.5;Y46B2A.C Protein containing a GLTT repeat region domain Y46B2A.D Y46B2A.1;Y46B2A.D Putative ortholog of C. elegans Y46B2_176.C gene product Y46C8AL.A Y46C8AL.1;Y46C8AL.A Protein of unknown function, putative paralog of C. elegans F47C12.4 Y46C8AL.B Y46C8AL.2;Y46C8AL.B Protein with weak similarity to D. melanogaster CG15306 (CG15306 gene product) Y46C8AL.D Y46C8AL.3;Y46C8AL.D Putative ortholog of C. elegans F56D6.1 gene product Y46C8AL.E Y46C8AL.4;Y46C8AL.E Putative ortholog of C. elegans F56D6.1 gene product Y46C8AL.H Y46C8AL.5;Y46C8AL.H Putative paralog of C. elegans Y46C8AL.E Y46C8AL.I Y46C8AL.6;Y46C8AL.I Putative paralog of C. elegans K04A8.7 Y46C8AL.J Y46C8AL.7;Y46C8AL.J Protein with moderate similarity to C. elegans pep-2 (Member of the proton-coupled oligopeptide transporter superfamily) Y46C8AL.K Y46C8AL.8;Y46C8AL.K Protein of unknown function, putative paralog of C. elegans Y46C8AL.L Y46C8AL.9;Y46C8AL.L Putative paralog of C. elegans Y46C8AL.K Y46C8AR.2 Y46C8AR.2 Protein with strong similarity to C. elegans Y46C8AL.3 gene product Y46C8AR.A Y46C8AR.1;Y46C8AR.A Protein with strong similarity to C. elegans F56D6.2 gene product Y46D2A.1 Y46D2A.1 Protein of unknown function, has strong similarity to C. elegans K11H12.4 Y46D2A.2 Y46D2A.2 Protein of unknown function, has strong similarity to C. elegans K11H12.4 Y46D2A.3 Y46D2A.3 Protein of unknown function, has moderate similarity to C. elegans Y8A9A.2 Y46E12A.1 Y46E12A.1 Protein with strong similarity to C. elegans Y46E12A.D gene product Y46E12A.3 Y46E12A.3 Putative ortholog of C. elegans Y46E12A.B gene product Y46E12A.C Y46E12A.2;Y46E12A.C Protein of unknown function Y46E12BL.1 Y46E12BL.1 Protein of unknown function Y46E12BL.1 encodes a predicted transforming growth factor beta homolog; Y46E12BL.1 has not yet been targeted in mutational or RNAi screens, so its role in C. elegans development and/or behavior is currently unknown; Y46E12BL.1 transcripts are detected in SAGE (serial analysis of gene expression) experiments. Y46E12BL.3 Y46E12BL.3 Putative ortholog of C. elegans Y46E12BL.4 gene product Y46E12BL.B Y46E12BL.4;Y46E12BL.B Putative ortholog of C. elegans Y46E12BL.3 gene product Y46E12BL.C Y46E12BL.2;Y46E12BL.C Protein of unknown function Y46G5.BB Y46G5A.23;Y46G5.BB Protein of unknown function Y46G5.D Y46G5A.4;Y46G5.D Protein with high similarity to U5 snRNP-specific protein 200 kDa (mouse U5-200-KD), which is an RNA unwindase, member of the DEAD or DEAH box ATP-dependent RNA helicase family, contains two Sec63 domains and a helicase conserved C-terminal domain Y46G5.E Y46G5A.5;Y46G5.E Protein with high similarity to phosphatidylinositol synthase (CDP-1,2-diacyl-sn-glycerol: 3-phosphatidyltransferase, human CDIPT), which acts in PI synthesis and PI:inositol exchange, member of the CDP-alcohol phosphatidyltransferase family Y46G5.GG Y46G5A.28;Y46G5.GG Protein with strong similarity to C. elegans PES-10, a putative transmembrane protein Y46G5.H Y46G5A.32;Y46G5.H TcA transposase Y46G5.M Y46G5A.12;Y46G5.M Protein contains a putative N-terminal coiled-coil region Y46G5.N Y46G5A.13;Y46G5.N Protein containing three RNA recognition motifs (RRM, RBD, or RNP), has moderate similarity to cytotoxic granule-associated RNA-binding protein 1 (human TIA1), which functions in mRNA splicing and apoptosis, and may be associated with HIV progression Y46G5.U Y46G5A.18;Y46G5.U Protein of unknown function Y46G5.W spds;Y46G5A.19;Y46G5.W Protein with similarity to human SRM (spermidine synthase) Y46G5A.1 Y46G5A.1 Putative ortholog of H. sapiens KIAA0019 (KIAA0019 gene product) Y46G5A.10 Y46G5A.10 Protein of unknown function Y46G5A.11 Y46G5A.11 Protein of unknown function Y46G5A.14 Y46G5A.14 Protein of unknown function, has weak similarity to C. elegans T07C12.10 Y46G5A.15 Y46G5A.15 Protein of unknown function, has weak similarity to C. elegans xnp-1 Y46G5A.17 Y46G5A.17 Putative ortholog of D. melanogaster CPTI (mitochondrial carnitine palmitoyltransferase I) Y46G5A.17 is orthologous to the human gene SIMILAR TO CARNITINE PALMITOYLTRANSFERASE I, LIVER (CPT1A; OMIM:600528), which when mutated leads to disease. Y46G5A.2 Y46G5A.2 Protein with strong similarity to S. cerevisiae COX10 (Farnesyl transferase required for heme A synthesis) Y46G5A.2 is orthologous to the human gene COX10 (YEAST) HOMOLOG, CYTOCHROME C OXIDASE ASSEMBLY PROTEIN (HEME A: FARNESYLTRANSFERASE) (COX10; OMIM:602125), which when mutated leads to disease. Y46G5A.20 Y46G5A.20 Protein of unknown function, has weak similarity to C. elegans Y39B6B.GG Y46G5A.21 dapat;Y46G5.X;Y46G5A.21 Member of the phospholipid and glycerol acyltransferase family, has a region of moderate similarity to a region of glyceronephosphate O acyltransferase (Acyl-CoA:dihydroxyacetonephosphate acyltransferase, mouse Gnpat), which acts in plasmalogen synthesis Y46G5A.21 is orthologous to the human gene GLYCERONEPHOSPHATE O-ACYLTRANSFERASE (GNPAT; OMIM:602744), which when mutated leads to disease. Y46G5A.24 Y46G5A.24 Putative ortholog of H. sapiens FLJ10730 (beta,beta-carotene 15,15'-dioxygenase homolog, chicken) Y46G5A.25 Y46G5A.25 Putative paralog of C. elegans ZK1010.9 Y46G5A.26 Y46G5A.26 Putative paralog of C. elegans H35N03.1 Y46G5A.27 pes-10;Y46G5.FF;Y46G5A.27 Protein of unknown function, has high similarity to uncharacterized C. elegans Y46G5A.28 This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins. Y46G5A.29 Y46G5A.29 Protein with moderate similarity to D. melanogaster N (Notch) Y46G5A.30 Y46G5A.30 Putative ortholog of H. sapiens SLC6A5 (solute carrier family 6 (neurotransmitter transporter, glycine), member 5) Y46G5A.31 Y46G5A.31 Putative ortholog of the S. cerevisiae GSY1 gene product, UDP-glucose-starch glucosyltransferase, or glycogen synthetase isoform 1 gsy-1 is orthologous to the human gene GLYCOGEN SYNTHASE 1 (GYS1; OMIM:138570); deficiencies of GYS1 may be associated with susceptibility to type 2 diabetes. Y46G5A.6 Y46G5A.6 Putative ortholog of H. sapiens U5-200-KD (U5 snRNP-specific protein, 200 kDa (DEXH RNA helicase family)) This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins. Y46G5A.7 Y46G5A.7 Protein of unknown function, putative paralog of C. elegans C47D12.4 This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins. Y46G5A.8 Y46G5A.8 Protein of unknown function, has weak similarity to C. elegans Y46G5A.7 This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins. Y46G5A.Y Y46G5A.22;Y46G5A.Y Protein of unknown function Y46H3A.1 Y46H3A.1 Protein of unknown function, putative paralog of C. elegans F36H9.6 7TM chemoreceptor, srt family Y46H3A.3 Y46H3A.3 Protein with strong similarity to C. elegans hsp-16.1 (Member of the C .elegans hsp-16 family) heat shock protein; hsp-16.2 encodes a 16-kD heat shock protein (HSP) that is a member of the hsp16/hsp20/alphaB-crystallin (HSP16) family of heat shock proteins; hsp-16.2 expression, strongest in intestine and pharynx, is induced in response to heat shock or other environmental stresses; HSP-16.2 has been shown to interact with intracellular human beta amyloid peptide, a primary component of the extracellular plaques found in Alzheimer's disease; HSP-16.2 is likely to function as a passive ligand temporarily preventing unfolded proteins from aggregating. Y46H3A.4 Y46H3A.4 Protein of unknown function, has moderate similarity to C. elegans Y49E10.R Y46H3A.5 Y46H3A.5 Protein of unknown function Y46H3A.6 Y46H3A.6 Putative paralog of C. elegans gly-7 (N-acetylgalactosaminyltransferase) N-acetylgalactosaminyltransferase; gly-7 encodes an N-acetylgalactosaminyltransferase that exhibits activity when expressed in COS7 cells. Y46H3A.A gly-7;Y46H3A.A N-acetylgalactosaminyltransferase Y46H3A.D hsp-16.2;Y46H3A.D Member of the heat shock HSP16-1 protein family Y46H3A.E hsp16-41;Y46H3A.2;Y46H3A.E Member of the Hsp20 or alpha crystallin family, has low similarity to alpha A crystallin (human CRYAA), which is a major structural protein of the eye lens that acts as a molecular chaperone and protects the lens epithelium from UVA stress Y46H3B.1 Y46H3B.1 Putative paralog of C. elegans Y46H3B.2 Y46H3B.2 Y46H3B.2 Putative paralog of C. elegans Y46H3B.1 Y46H3C.1 Y46H3C.1 Putative paralog of C. elegans Y46H3C.2 7TM chemoreceptor, srw family Y46H3C.2 Y46H3C.2 Putative paralog of C. elegans Y46H3C.1 7TM chemoreceptor, srw family Y46H3C.3 Y46H3C.3 Putative paralog of C. elegans K09D9.4 7TM chemoreceptor, srw family Y46H3C.4 Y46H3C.4 Putative paralog of C. elegans K12D12.1 (Member of the topoisomerase II protein family) Y46H3C.5 Y46H3C.5 Protein of unknown function, has strong similarity to C. elegans Y49E10.26 Y46H3C.6 Y46H3C.6 Protein with weak similarity to C. elegans C34D4.14 (Protein with strong similarity to ubiquitin-protein ligase) Y46H3D.1 Y46H3D.1 Protein of unknown function, has weak similarity to C. elegans Y40B10A_110.A Y46H3D.2 Y46H3D.2 Protein of unknown function, putative paralog of C. elegans Y46H3D.3 7TM chemoreceptor, str family Y46H3D.3 Y46H3D.3 Protein of unknown function, putative paralog of C. elegans Y46H3D.2 7TM chemoreceptor, str family Y46H3D.4 Y46H3D.4 Protein of unknown function, has strong similarity to C. elegans C31E10.3 Y46H3D.5 Y46H3D.5 Putative paralog of C. elegans F16B4.12 zinc finger protein; nhr-110 encodes a member of the nuclear hormone receptor family. Y46H3D.6 Y46H3D.6 Protein with strong similarity to C. elegans nhr-42 zinc finger protein Y46H3D.7 Y46H3D.7 Protein with strong similarity to C. elegans Y46H3D.6 zinc finger protein Y46H3D.A Y46H3D.8;Y46H3D.A Putative ortholog of C. elegans T05B4.10 gene product Y47A7.1 Y47A7.1 Protein with weak similarity to C. elegans Y49G5B.B gene product Y47A7.2 Y47A7.2 Protein of unknown function Y47C4A.A Y47C4A.1;Y47C4A_211.A;Y47C4A.A Member of the ATPase family associated with various cellular activities and of the M41 peptidase family of Zn metalloproteases, has high similarity to a region of S. cerevisiae Afg3p, which is involved in proteolysis and chaperon activity in mitochondria Y47D3A.1 Y47D3A.1 Putative ortholog of C. elegans pha-1 gene product Y47D3A.10 Y47D3A.10 Protein with moderate similarity to C. elegans Y73F8A.O gene product Y47D3A.11 Y47D3A.11 Putative ortholog of C. elegans C10C6.5 gene product Y47D3A.12 Y47D3A.12 Putative ortholog of C. elegans C24H11.3 gene product Y47D3A.13 Y47D3A.13 Putative ortholog of C. elegans W09D6.4 gene product Y47D3A.14 Y47D3A.14 Protein of unknown function Y47D3A.15 Y47D3A.15 Putative ortholog of C. elegans F55F3.1 gene product Y47D3A.17 Y47D3A.17 Member of the Oxysterol-binding protein family Y47D3A.2 Y47D3A.2 Protein with strong similarity to C. elegans C17B7.11 gene product Y47D3A.21 Y47D3A.21 Protein of unknown function Y47D3A.22 Y47D3A.22 Protein with moderate similarity to C. elegans C29E6.2 gene product Y47D3A.23 gly-9;Y47D3A.23 N-acetylgalactosaminyltransferase Y47D3A.25 Y47D3A.25 GTP-binding protein rab-35 encodes a small, monomeric Rab GTPase that is most closely related to the human and Drosophila Rab35 GTPases; by homology, RAB-35 is predicted to function as a membrane-associated GTPase required for intracellular vesicular trafficking and for regulation of endo- and exocytosis; however, as loss of rab-35 function via RNA-mediated interference (RNAi) does not result in any obvious abnormalities, the precise role of RAB-35 in C. elegans development and/or behavior is not yet known. Y47D3A.26 Y47D3A.26 Protein with moderate similarity to C. elegans mix-1 gene product Y47D3A.28 Y47D3A.28 Protein of unknown function Y47D3A.29 Y47D3A.29 Protein with strong similarity to C. elegans F10C2.4 gene product DNA polymerase alpha subunit Y47D3A.4 Y47D3A.4 Protein of unknown function Y47D3A.5 Y47D3A.5 Protein of unknown function Y47D3A.6 Y47D3A.6 Putative ortholog of C. elegans tra-1 gene product The tra-1 gene encodes a homolog of human GLI3, which when mutated leads to either Greig cephalopolysyndactyly syndrome or Pallister-Hall syndrome (OMIM:165240). Y47D3A.DD teg-1;Y47D3A.27;Y47D3A.DD Protein of unknown function Y47D3A.I tra-1;her-2;Y47D3A.L;Y47D3A.K;Y47D3A.J;Y47D3A.I Putative zinc-finger transcription factor involved in sex determination Y47D3B.1 Y47D38.1;Y47D3B.1 Protein of unknown function, has weak similarity to C. elegans ZK1025.7 Y47D3B.11 Y47D3B.11 Protein with weak similarity to H. sapiens RNF13 (Homo sapiens RING zinc finger protein (RZF) mRNA, complete cds) Y47D3B.2 Y47D38.2;Y47D3B.2 GGARAF neurotransmitter nlp-21 encodes nine predicted neuropeptide-like proteins; in C. elegans, nlp-21 is part of the GGARAF neuropeptide family that also contains nlp-9; nlp-21 is expressed in a variety of neurons, including AFD, five head neurons, the ventral nerve cord, one anterior pharyngeal neuron, and one tail neuron; nlp-21 expression is also detected in the embryo and the intestine; as loss of nlp-21 activity via large-scale RNAi screens does not result in any obvious abnormalities, the precise role of nlp-21-encoded peptides in development and/or behavior is not yet known. Y47D3B.3 Y47D38.3;Y47D3B.3 Protein of unknown function, has weak similarity to C. elegans Y37D8A.3 Y47D3B.4 Y47D38.4;Y47D3B.4 Protein of unknown function, has weak similarity to C. elegans C01G5.6 Y47D3B.5 Y47D38.5;Y47D3B.5 Member of the ion transport family, which include calcium, sodium, and potassium channels, has a region of weak similarity to a region of tandem pore domain potassium channel THIK-1 (rat Kcnk13) Y47D3B.6 Y47D38.6;Y47D3B.6 Protein with weak similarity to H. sapiens Hs.180780 (Homo sapiens agrin precursor mRNA, partial cds) Y47D3B.7 Y47D38.7;Y47D3B.7 Protein containing a helix-loop-helix DNA-binding domain, which mediate protein dimerization, has weak similarity to sterol regulatory element binding factor 1 (mouse Srebf1), which is a transcription factor involved in cholesterol biosynthesis Helix-loop-helix DNA-binding domain; sbp-1 encodes a basic helix-loop-helix (bHLH) transcription factor homologous to the mammalian Sterol Regulatory Element Binding Proteins (SREBPs, OMIM:184756, overexpression of nuclear form of SREBP-1c is associated with insulin resistance and features of congenital generalized lipodystrophy); in C. elegans, SBP-1 activity is required for normal lipid metabolism and wild-type levels of lipogenic enzyme expression, as well as for embryonic and larval development; sbp-1 expression is detected exclusively in the intestine, the major site of fat storage, from early embryogenesis through adulthood. Y47D3B.9 Y47D3B.9 Protein containing two BED zinc finger domains Y47D7A.1 Y47D7A.1 Putative ortholog of C. elegans Y47D7A.M gene product The skr-7 gene encodes a homolog of Skp1 in S. cerevisiae that is required for posterior body morphogenesis, embryonic and larval development, and cell proliferation. Y47D7A.10 Y47D7A.10 Protein with strong similarity to C. elegans Y47D7A.E gene product Y47D7A.11 Y47D7A.11 Protein with strong similarity to C. elegans Y47D7A.D gene product Y47D7A.12 Y47D7A.12 Protein with strong similarity to C. elegans Y47D7A.C gene product Y47D7A.13 Y47D7A.13 Protein with moderate similarity to C. elegans Y47D7A.A gene product Y47D7A.14 Y47D7A.14 Putative ortholog of C. elegans Y47D7A.A gene product Y47D7A.15 Y47D7A.15 Protein with strong similarity to C. elegans Y47D7A.B gene product Y47D7A.2 Y47D7A.2 Protein with strong similarity to C. elegans Y47D7A.L gene product Y47D7A.3 Y47D7A.3 Putative ortholog of C. elegans nhr-21 gene product Y47D7A.4 Y47D7A.4 Putative ortholog of C. elegans Y47D7A.K gene product Y47D7A.5 Y47D7A.5 Putative ortholog of C. elegans Y47D7A.J gene product Y47D7A.6 Y47D7A.6 Putative ortholog of C. elegans Y47D7A.I gene product Y47D7A.7 Y47D7A.7 Protein with strong similarity to C. elegans Y47D7A.6 gene product Y47D7A.9 Y47D7A.9 Protein with strong similarity to C. elegans Y47D7A.F gene product Y47D7A.G skr-14;Y47D7A.8;Y47D7A.G Putative paralog of C. elegans C52D10.6 Y47D9A.1 Y47D9A.1 Putative ortholog of D. melanogaster CG8207 mannose-1-phosphate gaunyl transferase Y47D9A.5 Y47D9A.5 Protein of unknown function Y47D9A.B Y47D9A.4;Y47D9A.B Protein with moderate similarity to C. elegans F46B6.10 gene product Y47D9A.D Y47D9A.3;Y47D9A.D Protein with strong similarity to C. elegans K06A4.1 gene product Y47D9A.F Y47D9A.2;Y47D9A.F Protein with strong similarity to C. elegans B0379.4 gene product Y47G6A.1 Y47G6A.1 Putative paralog of C. elegans Y47G6A.2 inx-21 encodes an innexin, an integral transmembrane channel protein that is a structural component of invertebrate gap junctions; as loss of INX-21 activity via RNA-mediated interference (RNAi) does not result in any abnormalities, the precise role of INX-21 in C. elegans development and/or behavior is not yet known; the INX-21 expression pattern has not been determined. Y47G6A.10 Y47G6A.10 Putative ortholog of S. cerevisiae YTA12 gene product, a mitochondrial protein involved with Afg3p in proteolytic and chaperonin activities in the inner membrane; member of the AAA family of ATPases ATPase Y47G6A.11 Y47G6A.11 Member of the MutS family, which are DNA mismatch repair proteins, contains a MutS family N-terminal DNA binding domain, has moderate similarity to mutS (E. coli) homolog 6 (mouse Msh6), which is a subunit of the MutS alpha complex DNA mismatch repair protein; msh-6 is orthologous to the human gene MUTS (E. | msh-6 is orthologous to the human gene MUTS (E. COLI) HOMOLOG 6 (MSH6; OMIM:600678), which when mutated leads to disease. Y47G6A.12 sep-1;Y47G6A.12 Required for chromosome segregation during meiosis I; putative paralog of C. elegans ZK430.5 The sep-1 gene encodes a homolog of separase, a protease that splits segregating chromosomes at their centromeres during anaphase by proteolyzing the Scc1 subunit of cohesin. Y47G6A.13 Y47G6A.13 Protein with strong similarity to C. elegans C53A5.4 protein kinase Y47G6A.14 Y47G6A.14 Protein with weak similarity to C. elegans T20F5.6 (Protein with a putative N-terminal zinc finger domain) zinc finger protein Y47G6A.15 Y47G6A.15 Protein with weak similarity to C. elegans unc-54 (Sarcomeric Myosin Heavy Chain, major component of thick filaments in body-wall muscle) Y47G6A.16 Y47G6A.16 Putative paralog of C. elegans T25G12.9 Y47G6A.17 Y47G6A.17 Protein with moderate similarity to C. elegans myo-1 (Myosin heavy chain) Y47G6A.18 Y47G6A.18 Putative ortholog of D. melanogaster CG7085 (CG7085 gene product) Y47G6A.19 Y47G6A.19 Putative paralog of C. elegans ZC434.9 carboxypeptidase Y47G6A.2 Y47G6A.2 Putative paralog of C. elegans Y47G6A.1 Y47G6A.20 Y47G6A.20 Protein containing five RNA recognition motifs (RRM, RBD, or RNP), has low similarity to siah (seven-in-absentia homolog) binding protein 1 (human SIAHBP1, fuse binding protein interacting repressor), which is a transcriptional repressor RNA-binding protein; rnp-6 encodes an ortholog of HALF-PINT in D. melanogaster and FBP Interacting Repressor (FIR)/PUF60 in mammals, predicted to be involved in mRNA splicing regulation, mRNA localization, or transcriptional regulation via TFIIH. Y47G6A.22 Y47G6A.22 Putative paralog of C. elegans Y47G6A.21 Y47G6A.23 Y47G6A.23 Putative ortholog of D. melanogaster CG15133 (CG15133 gene product) lpd-3 encodes a novel protein that is nevertheless conserved amongst humans, mice, and Drosophila; in C. elegans, LPD-3 activity is required for normal lipid metabolism, as animals that have reduced lpd-3 activity as a result of RNA-mediated gene interference (RNAi) lack lipid storage granules in the intestine and are paler and skinnier than wild-type animals; lpd-3 is expressed prominently in the intestine, the major site of fat storage. Y47G6A.24 Y47G6A.24 Protein of unknown function Y47G6A.25 Y47G6A.25 Protein of unknown function Y47G6A.26 Y47G6A.26 Protein of unknown function, has weak similarity to C. elegans T03F1.9 Y47G6A.27 Y47G6A.27 Putative ortholog of C. elegans C47C12.4 gene product Y47G6A.28 Y47G6A.28 Protein of unknown function Y47G6A.29 Y47G6A.29 Protein of unknown function Y47G6A.3 Y47G6A.3 Protein of unknown function, has weak similarity to C. elegans F32E10.6 Y47G6A.4 Y47G6A.4 Protein of unknown function Y47G6A.5 Y47G6A.5 Protein with strong similarity to C. elegans kin-22 (Putative tyrosine protein kinase, has strong similarity to human FYN-related kinase and D. melanogaster C-SRC homologs) tyrosine kinase Y47G6A.6 Y47G6A.6 Putative ortholog of H. sapiens PCAF (p300/CBP-associated factor) Y47G6A.7 Y47G6A.7 Protein with strong similarity to D. melanogaster CG14971 (CG14971 gene product) Y47G6A.8 Y47G6A.8 Putative ortholog of S. cerevisiae RAD27 gene product (Single-stranded DNA endonuclease and 5'-3' exonuclease that functions in the MSH2-MLH1-PMS1-dependent mismatch repair system) endonuclease Y47G6A.9 Y47G6A.9 Protein with weak similarity to C. elegans emb-5 (Putative effector of LIN-12) Y47G7B.1 Y47G7B.1 Member of the 7-transmembrane chemoreceptor family of G-protein coupled receptors (GPCR), has high similarity to uncharacterized C. elegans F14F9.7 7TM chemoreceptor, srh family Y47G7B.2 Y47G7B.2 Protein with strong similarity to C. elegans T24E12.5 gene product Y47G7B.3 Y47G7B.3 Putative ortholog of C. elegans F34D6.5 gene product 7TM chemoreceptor, sri family Y47H10A.1 Y47H10A.1 Putative ortholog of D. melanogaster CalpB (Calpain-B) A calpain protease involved in neurodegeneration caused by necrotic cell death. Y47H10A.2 Y47H10A.2 Protein of unknown function, has strong similarity to C. elegans Y39A1A.16 This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins. Y47H10A.3 Y47H10A.3 Protein of unknown function, putative paralog of C. elegans Y47H10A.5 Y47H10A.4 Y47H10A.4 Protein of unknown function, putative paralog of C. elegans Y47H10A.3 Y47H10A.5 Y47H10A.5 Protein of unknown function, putative paralog of C. elegans Y47H10A.3 Y47H9A.1 Y47H9A.1 Protein of unknown function, has very strong similarity to uncharacterized C. elegans C17D12.3 Y47H9B.1 Y47H9B.1 Protein of unknown function Y47H9B.2 Y47H9B.2 Protein of unknown function, has low similarity to uncharacterized C. elegans F35E2.3 Y47H9C.1 Y47H9C.1 Protein of unknown function, has high similarity to uncharacterized C. elegans ZK6.1 Y47H9C.10 Y47H9C.10 Protein containing a DUF38 domain of unknown function, has a region of low similarity to a region of C. elegans FOG-2, which is required for the sexual identity of germ cells Y47H9C.11 Y47H9C.11 Protein containing an F-box domain, which serve as a link between a target protein and a ubiquitin-conjugating enzyme, and a DUF38 domain of unknown function, has moderate similarity to uncharacterized C. elegans Y47H9C.10 This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins. Y47H9C.12 Y47H9C.12 Protein with moderate similarity to C. elegans Y47H9C.11 gene product Y47H9C.13 Y47H9C.13 Protein of unknown function, has weak similarity to C. elegans K07A1.5 Y47H9C.14 Y47H9C.14 Protein with moderate similarity to C. elegans B0513.3 Y47H9C.15 Y47H9C.15 Protein with moderate similarity to C. elegans csp-2 gene product Y47H9C.2 Y47H9C.2 Protein containing a DHHC-type zinc finger (NEW1) domain, has a region of low similarity to a region of S. cerevisiae Erf2p, which is involved in palmitoylation and localization of S. cerevisiae Ras2p Y47H9C.3 Y47H9C.3 Member of the Tc3 Transposase protein family Y47H9C.4 ced-1;Y47H9C.4 Notch family member; putative cell surface phagocytic receptor that recognizes cell corpses in apoptosis EGF-like domain; The ced-1 gene encodes a transmembrane protein on phagocytic cells that is homologous to human CD91, a low density lipoprotein receptor paralog; the cytoplasmic tail of CED-1 contains two motifs important for engulfment. Y47H9C.5 Y47H9C.5 Member of the thioredoxin family, which are small enzymes involved in redox reactions, contains a DnaJ domain, which are part of the chaperone (protein folding) system, has a region of low similarity to a region of calcium binding protein (mouse Cai) DnaJ domain ; Thioredoxin; This gene encodes a protein containing a DnaJ ('J') domain. Y47H9C.6 Y47H9C.6 Protein containing an interleukin-1 beta converting enzyme (ICE)-like protease (caspase) p10 domain, has low similarity to a region of C. elegans CED-3, which is a aspartate-specific cysteine protease that is involved in the induction of apoptosis ICE-like protease (caspase) p10 domain.; csp-3 encodes a protein that is homologous to the C-terminal domain of caspase-like cysteine proteases; unlike other caspases, CSP-3 does not contain a middle or N-terminal domain, and thus may either function in concert with the middle domains of other caspases or may play a regulatory (dominant negative) role in caspase activation; as loss of csp-3 activity via large-scale RNAi does not result in any obvious abnormalities, the precise role of CSP-3 in C. elegans development and/or behavior is not yet known. Y47H9C.7 Y47H9C.7 Member of the initiation factor 2 subunit family, has low similarity to the uncharacterized beta subunit of translation initiation factor 2B (rat Eif2b2), which is part of a heteropentamer that may mediate the exchange of GDP for GTP Initiation factor 2 subunit; Y47H9C.7 is orthologous to the human gene EUKARYOTIC TRANSLATION INITIATION FACTOR 2B, SUBUNIT 2 (BETA, 39KD) (EIF2B2; OMIM:606454), which when mutated leads to disease. Y47H9C.8 Y47H9C.8 Protein of unknown function, has low similarity to uncharacterized C. elegans F01F1.11 Y47H9C.9 Y47H9C.9 Protein of unknown function, has weak similarity to uncharacterized C. elegans T07F8.1 Y48A5A.1 Y48A5A.1 Putative ortholog of C. elegans Y48A5A.B gene product Y48A6A.1 zig-5;Y48A6A.1 Protein containing an immunoglobulin (Ig) domain, which may be involved in protein-protein and protein-ligand interactions, has low similarity to uncharacterized C. elegans ZIG-4 zig-5 encodes a predicted membrane-associated protein containing two C2-type immunoglobulin domains and a GPI (glycosylated phosphatidylinositol) anchor site, but no transmembrane domain; ZIG-5 is predicted to function in cell adhesion and/or signaling, and appears to be required for embryogenesis as well as maintenance of ventral nerve cord organization during larval stages; ZIG-5 is expressed in several different neurons and is detected in the PVT guidepost neuron beginning at the three-fold stage of embryogenesis and continuing throughout larval development. Y48A6B.1 Y48A6B.1 Protein of unknown function, has moderate similarity to uncharacterized C. elegans D1069.4 Y48A6B.10 Y48A6B.10 Protein of unknown function Y48A6B.11 Y48A6B.11 Protein of unknown function Y48A6B.13 Y48A6B.13 Protein of unknown function Y48A6B.2 Y48A6B.2 Protein of unknown function Y48A6B.3 Y48A6B.3 Protein with strong similarity to S. cerevisiae Nhp2p, a nucleolar protein required in association with H/ACA snoRNAs for ribosomal RNA pseudouridinylation Ribosomal protein L7Ae Y48A6B.4 Y48A6B.4 Protein of unknown function, has weak similarity to C. elegans C06E1.5 Y48A6B.5 Y48A6B.5 Protein of unknown function, has low similarity to uncharacterized human CSL4 Y48A6B.6 Y48A6B.6 Protein with high similarity to C. elegans EXP-2, which is an inward rectifying pharyngeal K-type (voltage activated) potassium channel, member of the ion transport family, contains a K+ channel tetramerization domain Ion transport proteins Y48A6B.7 Y48A6B.7 Protein containing a cytidine deaminase zinc-binding domain, has high similarity to uncharacterized C. elegans R13A5.10 Cytidine and deoxycytidylate deaminases zinc-binding region; This gene encodes a protein predicted by Eisenberg and coworkers, with 68% accuracy, to be mitochondrial. Y48A6B.8 Y48A6B.8 Protein of unknown function, has very strong similarity to uncharacterized C. elegans F49C5.3 Y48A6B.9 Y48A6B.9 Member of the zinc-containing alcohol dehydrogenase family, which catalyze reversible oxidation of ethanol to acetaldehyde, has moderate similarity to rat Nrbf1, which is a ligand-dependent nuclear receptor binding factor Zinc-binding dehydrogenases Y48A6C.1 Y48A6C.1 Protein containing a C2H2 type zinc finger domain, which bind nucleic acids, has a region of low similarity to a region of C. elegans T05G5.7, which is involved in embryogenesis and morphogenesis Y48A6C.2 Y48A6C.2 Protein of unknown function, has a region of very strong similarity to a region of C. elegans TRA-1, which is a putative zinc-finger transcription factor involved in sex determination Y48A6C.3 Y48A6C.3 Protein containing two C2H2 type zinc finger domains, which bind nucleic acids, has a region of low similarity to C. elegans T05G5.7, which is involved in embryogenesis and morphogenesis Zinc finger, C2H2 type (2 domains) Y48A6C.4 Y48A6C.4 Putative ortholog of C. elegans Y48A6C.1 gene product Y48A6C.5 pha-1;Y48A6C.5 Protein involved in pharyngeal development DNA-binding protein pha-1 Y48B6A.10 Y48B6A.10 Putative haspin-like protein kinase Y48B6A.12 Y48B6A.12 Putative ortholog of C. elegans Y48B6A.O gene product Y48B6A.13 Y48B6A.13 Putative ortholog of C. elegans Y48B6A.L gene product Y48B6A.14 Y48B6A.14 Putative ortholog of C. elegans hmg-1.1 gene product hmg-1.1 encodes a member of the high mobility group (HMG) family of proteins. Y48B6A.15 Y48B6A.15 Protein of unknown function, has strong similarity to acetylcholine esterases Y48B6A.4 Y48B6A.4 Putative ortholog of C. elegans acr-16 gene product eat-2 encodes a beta subunit of the nicotinic acetylcholine receptor (nAChR) superfamily which encode ligand-gated ion channels that regulate fast action of acetylcholine at neuromuscular junctions and in the nervous system; EAT-2 regulates the rate of pharyngeal pumping by by affecting MC pharyngeal neuron transmission, and is required for neurotransmission from the MC pharyngeal neuron to pharyngeal muscle, in which it is expressed, and also affects life span and defecation; eat-2 genetically interacts with eat-18, which encodes a predicted transcriptional activator also expressed in pharyngeal muscle. Y48B6A.7 Y48B6A.7 Protein of unknown function, similar to ace-3, acetylcholine esterase acetylcholinesterase; ace-4 encodes an divergent acetylcholinesterase homolog with biochemically undetectable activity. Y48B6A.9 hot-7;Y48B6A.J;Y48B6A.9 Putative acetylcholine esterase, Ly-6-related protein glycosylphosphatidylinositol (GPI)-linked signalling protein, (Ly-6 superfamily); hot-7 encodes a predicted membrane-associated protein that is a member of the Ly-6 superfamily of glycosylphosphatidylinositol (GPI)-linked signaling proteins and is homologous to ODR-2, a neuronally expressed protein required for olfaction; as loss of hot-7 activity via RNA-mediated interference (RNAi) does not result in any abnormalities, the precise role of HOT-7 in C. elegans development and/or behavior is not yet known. Y48B6A.A Y48B6A.1;Y48B6A.A Putative ortholog of S. cerevisiae Erb1p, a protein of unknown function Y48B6A.B Y48B6A.2;Y48B6A.B Protein with high similarity to ribosomal protein L43B (S. cerevisiae Rpl43bp), which is a ribosomal structural protein, member of the ribosomal L37ae family, which are part of the large ribosomal subunit and may bind zinc Y48B6A.C Y48B6A.3;Y48B6A.C Protein with moderate similarity to S. pombe Dhp1p, which is an essential exoribonuclease that is required for normal sister chromatid segregation and mRNA export Y48B6A.F Y48B6A.5;Y48B6A.F Protein containing a major sperm protein (MSP) domain, which are involved in sperm motility, has high similarity to uncharacterized C. elegans Y23H5A.4 Y48B6A.G Y48B6A.6;Y48B6A.G Protein containing two EF hand domains, which are found in signaling, buffering or transport proteins Y48B6A.I ace-4;ace-x;Y48B6A.H;Y48B6A.I Acetylcholine esterase with weakly transcribed mRNA; no catalytic activity detected Y48B6A.P Y48B6A.11;Y48B6A.P Protein containing a Jumonji (jmjC) domain and a (jumanji) jmjN domain, has a region of low similarity to a region of S. cerevisiae Rph1p, which is a DNA damage-responsive repressor of S. cerevisiae Phr1p Y48B6A.Q hmg-1.1;Y48B6A.Q Protein containing a high mobility group box (HMG1 or 2) family domain, has very strong similarity to uncharacterized C. elegans Y48B6A.14 Y48C3A.1 Y48C3A.1 Protein of unknown function Y48C3A.10 Y48C3A.10 Protein with weak similarity to D. melanogaster CG11258 (CG11258 gene product) Y48C3A.11 Y48C3A.11 Protein with moderate similarity to C. elegans F57B7.1 Y48C3A.12 Y48C3A.12 Protein with weak similarity to C. elegans lov-1 (Protein required for males to locate the hermaphrodite vulva, has similarity to mammalian PKD1 (polycystic kidney disease) proteins) Y48C3A.13 Y48C3A.13 Protein with weak similarity to C. elegans lov-1 (Protein required for males to locate the hermaphrodite vulva, has similarity to mammalian PKD1 (polycystic kidney disease) proteins) Y48C3A.14 Y48C3A.14 Putative ortholog of S. cerevisiae TOP3 gene product (DNA topoisomerase III, relaxes negatively (but not positively) supercoiled DNA) Y48C3A.15 Y48C3A.15 Protein with strong similarity to H. sapiens TOP3B (topoisomerase (DNA) III beta) Y48C3A.16 Y48C3A.16 Protein with strong similarity to H. sapiens PIN4 (protein (peptidyl-prolyl cis/trans isomerase) NIMA-interacting, 4 (parvulin)) Y48C3A.17 efl-2;Y48C3A.17 Weakly similar to H. sapiens E2F3, E2F transcription factor 3 The efl-2 gene encodes an E2F/DP1-like protein of as yet unknown function; comparative genomic analysis suggests that EFL-2 may be involved in apoptosis. Y48C3A.18 Y48C3A.18 Protein with weak similarity to S. cerevisiae SUA5 (Protein involved in translation initiation, mutation suppresses the effect of an aberrant upstream ATG in CYC1) Y48C3A.2 Y48C3A.2 Putative paralog of C. elegans B0213.1 (TcA transposase) Tc1 transposase Y48C3A.20 Y48C3A.20 Protein with weak similarity to D. melanogaster CG3709 (CG3709 gene product) Y48C3A.4 Y48C3A.4 Protein with weak similarity to C. elegans ama-1 (Largest subunit of RNA Polymerase II) Y48C3A.5 Y48C3A.5 Protein of unknown function Y48C3A.6 mac-1;Y48C3A.6 AAA ATPase that blocks cell death caused by CED-4 Y48C3A.9 Y48C3A.9 Protein with weak similarity to C. elegans sap-49 (Putative U2 snRNP-associated protein, putative ortholog of human spliceosome associated protein SAP49 and yeast Hsh49p) Y48C3A.G Y48C3A.3;Y48C3A.G Protein of unknown function, has low similarity to uncharacterized C. elegans K01D12.11 Y48C3A.I Y48C3A.7;Y48C3A.I Protein with very strong similarity to C. elegans MAC-1, which is an AAA ATPase that blocks cell death caused by C. elegans CED-4, member of the ATPase family associated with various cellular activities Y48C3A.J Y48C3A.8;Y48C3A.J Protein with weak similarity to S. cerevisiae FLO8 (Putative transcriptional activator of FLO1, required for diploid filamentous growth) Y48D7A.2 flp-18;FaRP_I;Y48D7A.2 Protein containing SVPGVLRF-amide neuromodulator flp-18 encodes the only FMRFamide-related neuropeptide (FaRP) encoded by the C. elegans genome, other than flp-21, that activates the solitary (215V) form of NPR-1 in Xenopus oocytes; in addition, FLP-18 can activated the social (215F) form of NPR-1 in pharyngeal assays; FLP-18 is expressed in the interneurons AVA, AIY and RIG, the motor neuron RIM and the pharyngeal neurons M2 and M3. Y48D7A.B Y48D7A.1;Y48D7A.B Protein with strong similarity to C. elegans R04D3.3 gene product Y48E1A.1 Y48E1A.1 Member of both the RNA polymerase alpha subunit family and the RNA polymerase A-beta'-A double prime family, has moderate similarity to RNA polymerase 1-4 (194 kDa subunit, rat A194), which is the largest subunit of RNA polymerase I DNA-directed RNA polymerase I largest subunit Y48E1B.1 Y48E1B.1 Protein of unknown function Y48E1B.10 Y48E1B.10 Protein containing glutathione S-transferase N-terminal and C-terminal domains, has moderate similarity to prostaglandin D2 synthase 2 (hematopoietic, rat Ptgds2), which functions as both a prostaglandin D synthase and a glutathione S-transferase glutathione S-transferase Y48E1B.11 Y48E1B.11 Protein with moderate similarity to C. elegans F23C8.J gene product Y48E1B.12 Y48E1B.12 Protein of unknown function Y48E1B.13 csp-1;Y48E1B.13 Caspase C14 peptidase; The csp-1 gene encodes, by alternative splicing, three caspase homologs that may be involved in apoptosis. Y48E1B.14 Y48E1B.14 Protein of unknown function Y48E1B.2 Y48E1B.2 Protein of unknown function BR-1 protein-like Y48E1B.3 Y48E1B.3 Putative geranylgeranyl transferase beta subunit geranylgeranyl transferase beta subunit Y48E1B.4 Y48E1B.4 Protein of unknown function Y48E1B.5 Y48E1B.5 Protein of unknown function Y48E1B.6 Y48E1B.6 Protein of unknown function Y48E1B.7 Y48E1B.7 Protein of unknown function, has high similarity to uncharacterized C. elegans AC8.5 Zinc finger, C2H2 type Y48E1B.8 Y48E1B.8 Protein of unknown function, has high similarity to uncharacterized C. elegans Y57G11C.31 Y48E1B.9 Y48E1B.9 Member of the C-type lectin family C-type lectin binding domain Y48E1C.1 Y48E1C.1 Protein of unknown function Y48E1C.2 Y48E1C.2 Protein of unknown function, has moderate similarity to uncharacterized S. pombe Spbc1778.07p Y48E1C.3 Y48E1C.3 Protein containing a TBC domain, which may be GTPase activators of Rab-like small GTPases, has a region of moderate similarity to a region of GTPase-activating protein for S. cerevisiae Ypt7p (S. cerevisiae Gyp7p) Probable rabGAP domains Y48G10A.1 Y48G10A.1 Putative ortholog of D. melanogaster CG4390 (CG4390 gene product) putative esterase Y48G10A.2 Y48G10A.2 Protein of unknown function, has strong similarity to C. elegans Y48G10A.B Y48G10A.3 Y48G10A.3 Putative paralog of C. elegans Y48G10A.D Y48G10A.4 Y48G10A.4 Protein of unknown function, putative paralog of C. elegans Y48G10A.B Y48G10A.5 Y48G10A.A;Y48G10A.5 Putative ortholog of C. elegans Y48G10A.4 gene product Y48G1A.2 Y48G1A.2 Protein with strong similarity to C. elegans Y48G1A.G gene product Y48G1A.3 Y48G1A.3 Putative ortholog of C. elegans Y48G1A.F gene product Y48G1A.5 Y48G1A.5 Putative ortholog of C. elegans Y48G1A.C gene product importin beta, nuclear transport factor; imb-5 encodes an importin-beta-like protein orthologous to mammalian CAS proteins (cellular apoptosis susceptibility) and Saccharomyces cerevisiae CSE1 (chromosome segregation 1); IMB-5 is predicted to function in nuclear transport of proteins required for mitotic progression or apoptosis as well as in re-export of importin-alpha, a nuclear import protein; in C. elegans, IMB-5 is essential for embryogenesis and required for normal pronuclear envelope dynamics, and may also play a role in vulval morphogenesis. Y48G1A.6 Y48G1A.6 Putative ortholog of C. elegans Y48G1A.A gene product Y48G1A.E Y48G1A.4;Y48G1A.E Protein with strong similarity to D. melanogaster CG5824 (CG5824 gene product) Y48G1A.H Y48G1A.1;Y48G1A.H Protein of unknown function, has weak similarity to C. elegans F58D12.3 Y48G1BL.1 Y48G1BL.1 Putative ortholog of C. elegans Y48G1BL.H gene product Y48G1BL.2 Y48G1BL.2 Putative ortholog of C. elegans atm-1 gene product atm-1 encodes an ortholog of human ATM (OMIM:208900) that is required for the checkpoint response to DNA damage; human ATM encodes a phosphatidylinositol-3 kinase homolog that is biochemically activated by cellular irradiation, and mutation of ATM leads to ataxia-telengiectasia. Y48G1BL.E puf-10;Y48G1BL.3;Y48G1C_55.G;Y48G1BL.E Member of the pumilio family of RNA binding domain proteins; required for germline development Y48G1BM.9 Y48G1BM.9 Putative ortholog of C. elegans Y48G1BM.A gene product Y48G1BM.C Y48G1BM.8;Y48G1BM.C Protein with strong similarity to C. elegans puf-7 gene product Y48G1BM.D Y48G1BM.7;Y48G1BM.D Protein of unknown function Y48G1BM.E Y48G1BM.6;Y48G1BM.E Putative ortholog of C. elegans Y54G2A.21 gene product Y48G1BM.F Y48G1BM.5;Y48G1BM.F Putative ortholog of C. elegans Y116F11B.K gene product Y48G1BM.G Y48G1BM.4;Y48G1BM.G Putative ortholog of C. elegans Y48G1BM.2 gene product Y48G1BM.I Y48G1BM.3;Y48G1BM.I Protein with strong similarity to C. elegans Y54B9A.1 gene product Y48G1BM.J Y48G1BM.2;Y48G1BM.J Putative ortholog of C. elegans Y48G1BM.4 gene product Y48G1BM.K Y48G1BM.1;Y48G1BM.K Putative ortholog of C. elegans B0273.3 gene product Y48G1BR.A Y48G1BR.1;Y48G1BR.A Protein of unknown function, has weak similarity to C. elegans C32E12.4 Y48G1C.2 Y48G1C.2 Putative ortholog of C. elegans Y48G1C.F gene product Y48G1C.4 Y48G1C.4 Putative ortholog of C. elegans Y48G1C.3 gene product Y48G1C.5 Y48G1C.5 Putative ortholog of C. elegans Y48G1C.D gene product Y48G1C.7 Y48G1C.7 Putative ortholog of C. elegans Y48G1C.B gene product Y48G1C.9 Y48G1C.9 Protein with strong similarity to C. elegans Y48G1C.F gene product Y48G1C.A Y48G1C.8;Y48G1C.A Protein of unknown function, putative paralog of C. elegans F16B12.6 Y48G1C.C Y48G1C.6;Y48G1C.C Protein of unknown function, has moderate similarity to C. elegans F45D11_40.G Y48G1C.E Y48G1C.3;Y48G1C.E Protein with moderate similarity to D. melanogaster CG7718 (CG7718 gene product) Y48G1C.G Y48G1C.1;Y48G1C.G Protein of unknown function Y48G8AL.1 Y48G8AL.1 Protein with strong similarity to C. elegans Y54G2A.30 gene product The Y48G8AL.1 gene encodes a homolog of human E6-AP ubiquitin-protein ligase, (UBE3A; OMIM:601623) which when mutated leads to one form of Angelman syndrome (OMIM:105830). Y48G8AL.10 Y48G8AL.10 Protein with moderate similarity to C. elegans Y55F3AM.14 gene product Y48G8AL.11 Y48G8AL.11 Protein with strong similarity to C. elegans Y57G11C.1 gene product Y48G8AL.12 Y48G8AL.12 Protein of unknown function Y48G8AL.2 Y48G8AL.2 Protein of unknown function Y48G8AL.5 Y48G8AL.5 Protein of unknown function Y48G8AL.6 Y48G8AL.6 Putative ortholog of C. elegans smg-2 gene product Y48G8AL.7 Y48G8AL.7 Protein of unknown function Y48G8AL.9 Y48G8AL.9 Protein of unknown function Y48G8AR.1 Y48G8AR.1 Putative ortholog of C. elegans Y48G8AR.B gene product grh-1 encodes a LSF/GRH transcription factor homolog required for normal cuticular synthesis and embryonic development; both GRH-1 and its Drosophila homolog GRAINYHEAD bind to DNA sites upstream of dbl-1, mab-5, and tdc-1; all three of these target genes are homologs of genes regulated by GRAINYHEAD in Drosophila; grh-1(RNAi) animals die as embryos with soft, defective cuticles, which resembles the phenotype seen in Drosophila grainyhead mutants. Y48G8AR.C Y48G8AR.2;Y48G8AR.C Protein with weak similarity to C. elegans C33D9.1 Y48G8AR.D Y48G8AR.3;Y48G8AR.D Protein of unknown function Y48G8A_3304.A smg-2;mab-11;Y48G8A_3304.A Involved in nonsense-mediated mRNA decay, mRNA surveillance, and RNAi-mediated gene suppression Y48G9A.1 Y48G9A.1 Putative ortholog of C. elegans Y48G9A.O gene product Y48G9A.4 Y48G9A.4 Putative ortholog of C. elegans Y48G9A.L gene product Y48G9A.8 Y48G9A.8 Putative ortholog of C. elegans Y48G9A.H gene product Y48G9A.9 Y48G9A.9 Putative ortholog of C. elegans Y48G9A.F gene product Y48G9A.B Y48G9A.12;Y48G9A.B Protein of unknown function Y48G9A.C Y48G9A.11;Y48G9A.C Protein of unknown function, has strong similarity to C. elegans T20F7.2 Y48G9A.E Y48G9A.10;Y48G9A.E Putative paralog of C. elegans F09F3.9 Y48G9A.I Y48G9A.7;Y48G9A.I Protein of unknown function, has weak similarity to C. elegans R08E5.4 Y48G9A.J Y48G9A.6;Y48G9A.J Protein of unknown function Y48G9A.K Y48G9A.5;Y48G9A.15;Y48G9A.K Putative paralog of C. elegans C31A11.8 (TcA transposase) Y48G9A.M Y48G9A.3;Y48G9A.M Protein of unknown function Y48G9A.N Y48G9A.2;Y48G9A.N Protein of unknown function Y49A10A.1 Y49A10A.1 Protein of unknown function Y49A3A.3 Y49A3A.3 Protein of unknown function Y49A3A.5 cyp-1;Y49A3A.D;Y49A3A.5 Cyclophilin-related peptidylprolyl cis-trans-isomerase Peptidyl-prolyl cis-trans isomerase; cyp-1 encodes a functional cyclophilin that is predicted to be secreted; expression increases as worms progress from the L1 larval stage to the adult stage. Y49A3A.A Y49A3A.1;Y49A3A.A Protein with high similarity to choline-ethanolaminephosphotransferase (human CEPT1), which catalyzes the formation of phosphatidylcholine or phosphatidylethanolamine from diacylglycerol, member of the CDP-alcohol phosphatidyltransferase family Y49A3A.B Y49A3A.2;Y49A3A.B Protein with strong similarity to mouse Atp6a2, which is a vacuolar H+-ATPase alpha subunit that is involved in the maintenance of cytoplasmic pH, contains ATP synthase alpha or beta family beta-barrel, nucleotide-binding, and C-terminal domains Y49A3A.E Y49A3A.4;Y49A3A.E Protein of unknown function, has weak similarity to C. elegans F48G7.5 Y49C4A.1 Y49C4A.1 Putative ortholog of C. elegans Y49C4A.3 gene product Y49C4A.2 Y49C4A.2 Putative ortholog of C. elegans Y49C4A.3 gene product Y49C4A.3 Y49C4A.3 Putative ortholog of C. elegans Y49C4A.E gene product Y49C4A.4 Y49C4A.4 Putative ortholog of C. elegans Y49C4A.E gene product 7TM chemoreceptor, srx family Y49C4A.5 Y49C4A.5 Putative ortholog of C. elegans Y49C4A.C gene product 7TM chemoreceptor, srx family Y49C4A.6 Y49C4A.6 Putative ortholog of C. elegans T03D3.14 gene product 7TM chemoreceptor, srj family Y49C4A.8 Y49C4A.8 Putative ortholog of C. elegans C10H11.3 gene product Y49C4A.9 Y49C4A.9 Putative ortholog of C. elegans C45H4.2 gene product Y49E10.1 rpt-6;Y49E10.B;Y49E10.1 Putative ATPase subunit of 19S proteasome particle ATPases associated with various cellular activities (AAA); rpt-6 encodes a triple A ATPase that is a subunit of the 26S proteasome 19S regulatory particle (RP) base subcomplex; RPT-6 is required for embryonic and larval development and by homology, is predicted to function in unfolding protein substrates and translocating them into the core proteolytic particle (CP) of the proteasome. Y49E10.14 pie-1;Y49E10.N;Y49E10.14 Germline protein required for silencing transcription in early germ line precursors Zinc finger C-x8-C-x5-C-x3-H type (and similar).; pie-1 encodes a C-x8-C-x5-C-x3-H-type zinc-finger protein; maternally provided PIE-1 is essential for germline cell fate determination, as it functions as a repressor of RNA polymerase II-dependent gene expression in the developing germ line; PIE-1 localization, initially uniform and then concentrated in the posterior germ cell lineages, is regulated by other maternally supplied gene products including PAR-1, MEX-5, and MEX-6. Y49E10.15 Y49E10.O;Y49E10.15 Protein with high similarity to small nuclear ribonucleoprotein E (human SNRPE), which is a small nuclear ribonucleoprotein (snRNP) that forms a 6S core particle with other snRNPs and may be involved in snRNP maturation, member of the Sm family Y49E10.16 Y49E10.P;Y49E10.16 Member of the lipase class 3 family, which are a subset of lipolytic enzymes that hydrolyze ester linkages of triglycerides, has high similarity to uncharacterized C. elegans Y49E10.R Y49E10.17 Y49E10.Q;Y49E10.17 Protein containing a DUF38 domain of unknown function Y49E10.18 Y49E10.R;Y49E10.18 Member of the lipase class 3 family, which are a subset of lipolytic enzymes that hydrolyze ester linkages of triglycerides, has high similarity to uncharacterized C. elegans Y49E10.P Y49E10.2 Y49E10.D;Y49E10.2 Protein with high similarity to glutaredoxin (S. cerevisiae Grx5p), which is involved in protection against protein oxidative damage This gene encodes a protein predicted by Eisenberg and coworkers, with 52% accuracy, to be mitochondrial. Y49E10.21 Y49E10.U;Y49E10.21 Protein of unknown function Y49E10.22 Y49E10.W;Y49E10.22 Protein of unknown function, has weak similarity to C. elegans Y95B8A_85.H Y49E10.24 Y49E10.Z;Y49E10.24 Protein of unknown function, has a region of low similarity to a region of vitamin D-3 upregulated protein-1 (human TXNIP), which inhibits thioredoxin activity and may contribute to cellular redox associated with myeloid and macrophage differentiation Y49E10.25 Y49E10.25 Putative ortholog of C. elegans Y49E10.R gene product Y49E10.26 Y49E10.26 Protein of unknown function, putative paralog of C. elegans Y49E10.H Y49E10.4 Y49E10.F;Y49E10.4 Member of the thioredoxin family, which are small enzymes involved in redox reactions, has moderate similarity to protein disulfide isomerase-related protein (rat CaBP1), which catalyzes disulfide isomerization and the formation of disulfide bonds Thioredoxin Y49E10.6 Y49E10.A;Y49E10.6 Protein with very strong similarity to H3 histone family 3A (mouse H3f3a), which is a replacement histone expressed independently of DNA replication and is required for normal growth rates, member of the histone family of nucleosomal core proteins Core histone H2A/H2B/H3/H4; his-72 encodes an H3 histone required for embryonic viability. Y49E10.7 Y49E10.7 Putative ortholog of C. elegans Y45F10C.1 gene product Y49E10.8 Y49E10.8 Putative ortholog of C. elegans B0513.6 gene product Y49E10.E pph-4.2;Y49E10.3;Y49E10.E Protein with high similarity to protein phosphatase 4 catalytic (mouse Ppp4c), which may activate nuclear factor kappa B and stimulate c-Rel binding to DNA, member of the serine or threonine protein phosphatase family Y49E10.I Y49E10.9;Y49E10.I Member of the ABC transporter family, has a region of low similarity to a region of mouse Abcg1 (ATP-binding cassette subfamily G member 1), which is an ABC transporter involved in cellular sterol homeostasis Y49E10.J Y49E10.10;Y49E10.J Protein of unknown function, has a region of moderate similarity to a region of carboxyl ester lipase (human CEL), which hydrolyzes cholesterol and dietary esters and is involved in the intestinal absorption of dietary lipids and fat soluble vitamins Y49E10.L Y49E10.11;Y49E10.L Member of the haloacid dehalogenase or epoxide hydrolase family, has moderate similarity to S. cerevisiae Drs2p, which is a membrane-spanning Ca-ATPase (P-type) required for ribosome assembly and involved in late Golgi function Y49E10.S Y49E10.19;Y49E10.S Protein containing a C-terminal pleckstrin homology (PH) domain, which mediate protein-protein and protein-lipid interactions, has weak similarity to anillin (human ANLN), which is an actin binding protein that may play a role in cytokinesis Y49E10.T Y49E10.20;Y49E10.T Member of the CD36 family of putative scavenger receptors, has low similarity to scavenger receptor BI (rat Cd36l1), which mediates the selective uptake of cholesterol from high density lipoprotein Y49E10.Y Y49E10.23;Y49E10.Y Putative coiled-coil protein, has weak similarity to S. cerevisiae Uso1p, required for protein transport from ER to Golgi Y49F6A.2 Y49F6A.2 Protein of unknown function, putative paralog of C. elegans R05D8.3 7TM chemoreceptor, srh family Y49F6A.5 Y49F6A.5 Protein of unknown function, putative paralog of C. elegans Y49F6A_1689.A Y49F6A.D srh-305;Y49F6A.3;Y49F6A.D Chemoreceptor Y49F6A.F Y49F6A.1;Y49F6A.F Putative ortholog of C. elegans C16C10.3 gene product Y49F6B.1 Y49F6B.1 Putative paralog of C. elegans Y49F6B_108.I Y49F6B.10 Y49F6B.10 Putative paralog of C. elegans sqt-3 (Collagen) Y49F6B.11 Y49F6B.11 Protein of unknown function, putative paralog of C. elegans Y49F6B_108.C 7TM chemoreceptor, srz family Y49F6B.2 Y49F6B.2 Putative paralog of C. elegans Y49F6B_108.H Y49F6B.3 Y49F6B.3 Protein of unknown function, has weak similarity to C. elegans C08F1.3 Y49F6B.4 smu-2;Y49F6B.4 Involved in body development smu-2 encodes a protein with homology to the mammalian nuclear protein RED that affects the accumulation of alternatively spliced unc-52 transcripts; may function in a pathway with smu-1, interacts in vitro with SMU-1, and may be required for normal expression levels of SMU-1. Y49F6B.5 Y49F6B.5 Protein of unknown function, putative paralog of C. elegans Y49F6B_110.F Y49F6B.6 Y49F6B_110.E;Y49F6B.L;Y49F6B.6 Protein of unknown function Y49F6B.7 Y49F6B.7 Protein of unknown function, putative paralog of C. elegans Y49F6B.F Y49F6B.8 Y49F6B.8 Protein of unknown function, putative paralog of C. elegans Y49F6B.F Y49F6B.9 Y49F6B.9 Putative paralog of C. elegans Y49F6B_108.E Y49F6C.2 Y49F6C.H;Y49F6C.2 Protein with strong similarity to C. elegans Y49F6C.3 gene product Y49F6C.4 Y49F6C.4 Putative ortholog of C. elegans Y49F6C.3 gene product Y49F6C.5 Y49F6C.F;Y49F6C.5 Protein containing a meprin and TRAF homology domain and a BTB or POZ domain, which are found in some DNA and actin binding proteins and may mediate protein-protein interactions, has high similarity to uncharacterized C. elegans B0047.5 Y49F6C.6 Y49F6C.C;Y49F6C.6 Putative ortholog of C. elegans M70.E gene product Y49F6C.8 Y49F6C.A;Y49F6C.8 Protein of unknown function Y49F6C.B Y49F6C.7;Y49F6C.B Protein of unknown function, has weak similarity to C. elegans Y55B1B_119.A Y49F6C.G Y49F6C.3;Y49F6C.G Protein containing a meprin and TRAF homology (MATH) domain and a BTB (BR-C, ttk and babor) or POZ (Pox virus and zinc finger) domain, which are found in some DNA and actin binding proteins, has high similarity to C. elegans Y49F6C.4 Y49F6C.I Y49F6C.1;Y49F6C.I Protein containing a meprin and TRAF homology (MATH) domain and a BTB (BR-C, ttk and babor) or POZ (Pox virus and zinc finger) domain, which are found in some DNA and actin binding proteins, has high similarity to uncharacterized C. elegans Y49F6C.3 Y49G5A.A Y49G5A.1;Y49G5A.A Protein containing one kunitz or bovine pancreatic trypsin inhibitor domain, has moderate similarity to uncharacterized C. elegans K11D12.7 Y49G5B.1 Y49G5B.C;Y49G5B.1 Protein of unknown function Y4C6A.1 Y4C6A.1 Putative paralog of C. elegans T06C10.3 protein kinase Y4C6A.2 Y4C6A.2 Putative ortholog of H. sapiens GRM3 (glutamate receptor, metabotropic 3) glutamate receptor Y4C6A.3 Y4C6A.3 Protein with weak similarity to H. sapiens KIAA0517 (Homo sapiens mRNA for KIAA0517 protein, partial cds) zinc finger protein Y4C6B.1 Y4C6B.H;Y4C6B.1 Protein of unknown function Y4C6B.2 Y4C6B.G;Y4C6B.2 Member of an uncharacterized protein family Y4C6B.3 Y4C6B.3 Putative ortholog of C. elegans Y4C6B.E gene product Y4C6B.4 Y4C6B.4 Putative ortholog of C. elegans T22F3.11 gene product Y4C6B.5 Y4C6B.5 Putative ortholog of C. elegans Y4C6B.E gene product Y4C6B.6 Y4C6B.6 Putative ortholog of C. elegans Y4C6B.D gene product The Y4C6B.6 gene encodes a homolog of the human gene GLCM, which when mutated leads to Gaucher disease type I (OMIM:230800). Y50C1A.1 Y50C1A.1 Protein with moderate similarity to H. sapiens TNFAIP3 (tumor necrosis factor, alpha-induced protein 3) The Y50C1A.1 gene encodes an A20-like protease homolog that may be involved in apoptosis. Y50C1A.2 Y50C1A.2 Protein of unknown function, has moderate similarity to C. elegans D1046.5 Y50D4A.1 Y50D4A.1 Putative ortholog of C. elegans Y50D4A.H gene product Y50D4A.3 Y50D4A.3 Putative ortholog of C. elegans C08B6.4 gene product Y50D4A.4 Y50D4A.4 Putative ortholog of C. elegans Y50D4A.C gene product Y50D4A.F Y50D4A.2;Y50D4A.F Protein of unknown function, has weak similarity to C. elegans Y56A3A.9 Y50D4B.1 Y50D4B.1 Putative ortholog of C. elegans Y50D4B.F gene product Y50D4B.2 Y50D4B.2 Putative ortholog of C. elegans Y50D4B.E gene product Y50D4B.3 Y50D4B.3 Putative ortholog of C. elegans C17D12.3 gene product Y50D4B.4 Y50D4B.4 Putative ortholog of C. elegans C17D12.3 gene product Y50D4B.5 Y50D4B.5 Putative ortholog of C. elegans Y50D4B.C gene product Y50D4B.6 Y50D4B.6 Putative ortholog of C. elegans Y50D4B.B gene product Y50D4B.7 Y50D4B.7 Putative ortholog of C. elegans Y50D4B.A gene product Y50D4C.D Y50D4C.4;Y50D4C.D Protein of unknown function Y50D4C.E Y50D4C.3;Y50D4C.E Protein of unknown function Y50D4C.G Y50D4C.2;Y50D4C.G Putative ortholog of C. elegans H24K24.3 gene product Y50D4C.I Y50D4C.1;Y50D4C.I Protein of unknown function Y50D7A.10 Y50D7A.10 Protein of unknown function Y50D7A.2 Y50D7A.2 Putative ortholog of C. elegans Y50D7A.I gene product Y50D7A.2 is orthologous to the human gene SIMILAR TO XERODEMA PIGMENTOSUM D (ERCC2; OMIM:126340), which when mutated leads to disease. Y50D7A.3 Y50D7A.3 Putative ortholog of C. elegans Y50D7A.G gene product Y50D7A.3 is orthologous to human PHOSPHORYLASE KINASE, TESTIS/LIVER, GAMMA-2 (PHKG2; OMIM:172471), which when mutated leads to liver glycogenosis and cirrhosis. Y50D7A.4 Y50D7A.4 Putative ortholog of C. elegans Y50D7A.F gene product Y50D7A.5 Y50D7A.5 Putative ortholog of C. elegans Y50D7A.F gene product Y50D7A.6 Y50D7A.6 Putative ortholog of C. elegans krp85 gene product Y50D7A.7 Y50D7A.7 Protein required for a normal rate of growth and development ads-1 encodes an ortholog of human ALKYL-DIHYDROXYACETONEPHOSPHATE SYNTHASE PRECURSOR (AGPS; OMIM:603051) that is required for normal larval development; mutation of human AGPS leads to type 3 rhizomelic chondrodysplasia punctata (OMIM:600121). Y50D7A.8 Y50D7A.8 Putative ortholog of C. elegans Y50D7A.A gene product Y50D7A.9 Y50D7A.9 Putative ortholog of C. elegans Y50D7A.I gene product Y50D7A.L Y50D7A.1;Y50D7A.L Protein with weak similarity to D. melanogaster CG6758 Y50E8A.1 Y50E8A.A;Y50E8.A;Y50E8A.1 Protein of unknown function Y50E8A.12 Y50E8A.R;Y50E8.Q;Y50E8A.12 Protein of unknown function Y50E8A.14 Y50E8A.14 Protein of unknown function, putative paralog of C. elegans Y50E8A.L Y50E8A.15 Y50E8A.J;Y50E8.K;Y50E8A.15 Protein with strong similarity to C. elegans Y75D11A.5 gene product Y50E8A.16 Y50E8A.16 Putative ortholog of S. cerevisiae MDL2 gene product (Member of the ATP-binding cassette (ABC) superfamily, equivalent to a "half-sized" ABC protein) Y50E8A.2 Y50E8A.B;Y50E8.B;Y50E8A.2 Protein of unknown function, has strong similarity to a region of C. elegans MSP-142, which is a sperm-specific protein involved in sperm motility Y50E8A.3 Y50E8A.3 Putative member of Immunoglobulin superfamily Y50E8A.4 unc-61;Y50E8A.4 Septin, involved in cytokinesis unc-61, by alternative splicing, encodes two septin isoforms required (like the septin UNC-59) for normal axonal migration, distal tip cell migration, and postembryonic cytokinesis (at the cellular level) and for normal locomotion and formation of the postembryonic vulva, somatic gonad, and male tail (at the organismal level); both UNC-61A/B and UNC-59 are dispensable for embryonic cytokinesis and development, but are thought to be required for all postembryonic cytokinesis; UNC-61A/B and UNC-59 depend on each other for localization to the cytokinetic furrow. Y50E8A.5 Y50E8A.E;Y50E8.E;Y50E8A.5 Protein of unknown function Y50E8A.6 Y50E8A.F;Y50E8.F;Y50E8A.6 Member of the FAD dependent oxidoreductase family, which catalyze oxidation of D-amino acids into the corresponding keto acids, has moderate similarity to mitochondrial glycerol-3-phosphate dehydrogenase (rat Gpd2) Y50E8A.7 Y50E8A.7 Putative paralog of C. elegans Y50E8A.G Y50E8A.9 Y50E8A.O;Y50E8.N;Y50E8A.9 Protein with low similarity to plasma membrane phospholipid scramblase 1 (human PLSCR1), which mediates Ca2+-dependent movement of membrane phospholipids in activated, injured, or apoptotic cells and may play a role in the response to DNA damage Y50E8A.9 encodes a homolog of human scramblase (PLSCR1; OMIM:604170), which is activated by a rise of intracellular calcium, and which promotes the exposure of phosphatidylserine on the surface of cells undergoing activation, injury, or apoptosis; paralogs of Y50E8A.9 include F46A8.9, F46A8.10, K08D10.7, K08D10.8, and Y50E8A.9. Y50F7A.A Y50F7A.2;Y50F7A.A Protein of unknown function Y51A2A.1 Y51A2A.1 Protein with strong similarity to C. elegans F49H6.2 gene product Y51A2A.10 Y51A2A.10 Protein with strong similarity to C. elegans wee-1.3 gene product Y51A2A.3 Y51A2A.3 Protein of unknown function, has moderate similarity to uncharacterized C. elegans Y17D7B.5 Y51A2A.4 Y51A2A.4 Protein with strong similarity to C. elegans Y51A2A.7 gene product Y51A2A.5 Y51A2A.5 Protein of unknown function, has low similarity to uncharacterized C. elegans Y67D8C.2 Y51A2A.6 Y51A2A.6 Protein of unknown function, has moderate similarity to uncharacterized C. elegans M162.1 Y51A2A.7 Y51A2A.7 Protein containing a C-type lectin domain, which mediate calcium-dependent carbohydrate recognition, has low similarity to uncharacterized C. elegans ZK39.8 Lectin C-type domain Y51A2A.9 Y51A2A.9 Protein containing an F-box domain, which serve as a link between a target protein and a ubiquitin-conjugating enzyme, and a DUF38 domain of unknown function, has low similarity to C. elegans FOG-2, which is required for the sexual identity of germ cells Y51A2B.1 Y51A2B.1 Protein with strong similarity to C. elegans C07G3.2 gene product Y51A2B.2 Y51A2B.2 Protein of unknown function, has high similarity to uncharacterized C. elegans F58F6.6 Y51A2B.3 Y51A2B.3 Protein of unknown function, has low similarity to a region of C. elegans NHR-58, which is a member of the nuclear hormone receptor-zinc finger protein family Domain of unknown function Y51A2B.4 Y51A2B.4 Member of the lipase class 3 family, which are a subset of lipolytic enzymes that hydrolyze ester linkages of triglycerides, has weak similarity to uncharacterized C. elegans Y49E10.R Y51A2B.5 Y51A2B.5 Protein of unknown function Y51A2B.6 Y51A2B.6 Protein containing two WSN domains of unknown function, has high similarity to uncharacterized C. elegans M162.7 Y51A2C.1 Y51A2C.1 TcA transposase Tc1 transposase Y51A2D.1 Y51A2D.1 Member of the papain family of cysteine proteases, has low similarity to cathepsin H (mouse Ctsh), which is a cysteine (thiol) protease involved in a variety of proteolytic processes and may be involved in basement membrane fragmentation Cysteine proteases (2 domains) Y51A2D.10 Y51A2D.10 Member of the transthyretin-like family, has high similarity to uncharacterized C. elegans Y51A2D.9 Transthyretin-like family Y51A2D.11 Y51A2D.11 Member of the transthyretin-like family, has high similarity to uncharacterized C. elegans F09F3.6, Transthyretin-like family Y51A2D.12 Y51A2D.12 Protein of unknown function, has moderate similarity to uncharacterized C. elegans K04C1.6 Y51A2D.13 Y51A2D.13 Protein containing a phospholipase D active site motif, has moderate similarity to uncharacterized phospholipase D3 (mouse Pld3), which may play a role in signal transduction and neurogenesis phospholipase D Y51A2D.14 Y51A2D.14 Protein of unknown function, has weak similarity to C. elegans C54F6.6 Y51A2D.15 Y51A2D.15 Protein of unknown function Y51A2D.16 Y51A2D.16 Putative coiled-coil protein, has similarity to human a centromere protein CENPE Y51A2D.17 nhr-70;Y51A2D.17 Protein of unknown function, has similarity to zinc-finger domain Zinc finger, C4 type (two domains) Y51A2D.18 Y51A2D.18 Protein of unknown function, putative sugar transporter Sugar (and other) transporter Y51A2D.19 Y51A2D.19 Putative ortholog of D. melanogaster slo (slowpoke) slo-1 mutants have wild-type levels of motor activity, but have less smooth movement and tend to stop and reverse direction. Y51A2D.4 Y51A2D.4 Member of the sugar (and other) transporter family, has low similarity to S. pombe Itr2p, which is an essential myo-inositol transporter Sugar (and other) transporters Y51A2D.5 Y51A2D.5 Member of the sugar (and other) transporter family, has low similarity to myo-inositol permease (major) (S. cerevisiae Itr1p), which is involved in sterol metabolism Sugar (and other) transporters Y51A2D.7 Y51A2D.7 Protein with moderate similarity to C. elegans Y50D4A.4 gene product Y51A2D.8 Y51A2D.8 Member of the papain family of cysteine proteases, has low similarity to C. elegans CPL-1, which is involved in embryogenesis and morphogenesis and in extracellular matrix organization and biogenesis Cysteine proteases (2 domains) Y51A2D.9 Y51A2D.9 Member of the transthyretin-like family, has high similarity to uncharacterized C. elegans Y51A2D.10 Transthyretin-like family Y51B9A.3 Y51B9A.3 Putative ortholog of C. elegans F18C5.4 gene product Y51B9A.4 Y51B9A.4 Protein of unknown function, has low similarity to uncharacterized C. elegans F48F7.7 Y51B9A.5 Y51B9A.5 Protein of unknown function, has weak similarity to C. elegans F36A2.12 Y51B9A.6 Y51B9A.6 Member of the sugar (and other) transporter family, has weak similarity to solute carrier family 17 member 1 (mouse Slc17a1), which is involved in sodium-dependent phosphate transport and mediates hepatic and renal anion drug transport Sugar (and other) transporters Y51B9A.7 Y51B9A.7 Protein of unknown function Y51B9A.8 Y51B9A.8 Protein of unknown function, has weak similarity to uncharacterized C. elegans F15A4.6 Y51B9A.9 Y51B9A.9 Protein containing a protein kinase domain, has moderate similarity to jun N-terminal kinase 2 (mouse Mapk9), which is an apoptosis inducer that regulates c-Jun (Jun) in response to proinflammatory cytokines and is also involved in the immune response serine/threonine kinase Y51F10.1 Y51F10.1 Protein with strong similarity to C. elegans T02G5.5 gene product transposase Y51F10.10 Y51F10.10 Protein with moderate similarity to C. elegans Y92H12A.4 gene product Y51F10.2 Y51F10.2 Protein with moderate similarity to C. elegans B0281.3 gene product Y51F10.3 Y51F10.3 Protein of unknown function Y51F10.4 Y51F10.4 Putative ortholog of C. elegans Y92H12A.4 gene product Y51F10.5 Y51F10.5 Protein with strong similarity to C. elegans C14C11.3 gene product Y51F10.6 Y51F10.6 Protein of unknown function Y51F10.7 Y51F10.7 Putative ortholog of C. elegans C17F4.7 gene product Y51F10.8 Y51F10.8 Putative ortholog of C. elegans Y58G8A_207.A gene product Y51F10.9 Y51F10.9 Protein with weak similarity to C. elegans ZK180.2 gene product Y51H1A.1 Y51H1A.1 Protein with moderate similarity to C. elegans Y56A3A.N gene product Y51H1A.2 Y51H1A.2 Protein containing a RUN domain, which may be involved in Ras-like GTPase signaling pathways Y51H1A.3 Y51H1A.3 Protein of unknown function Y51H1A.4 Y51H1A.4 Protein containing a PHD-finger, which may be involved in chromatin-mediated transcriptional regulation, has a region of high similarity to a region of S. cerevisiae Yng2p, which is a component of the NuA4 histone acetyltransferase complex PHD-finger.; Y51H1A.4 is orthologous to the human gene P33ING1B (ING1; OMIM:601566), which when mutated leads to disease. Y51H1A.5 Y51H1A.5 Member of the histone deacetylase family, which catalyze removal of acetyl groups from histones, has moderate similarity to a region of histone deacetylase 6 (human HDAC6) Histone deacetylase family Y51H1A.6 Y51H1A.6 Protein containing a C2H2 type zinc finger domain, which bind nucleic acids Zinc finger, C2H2 type Y51H1A.7 Y51H1A.7 Protein of unknown function Y51H4A.1 Y51H4A.A;Y51H4A.1 Protein of unknown function Y51H4A.10 Y51H4A.J;Y51H4A.10 Protein of unknown function Y51H4A.12 Y51H4A.12 Putative paralog of C. elegans Y51H4A.L Y51H4A.13 Y51H4A.13 Putative paralog of C. elegans Y51H4A.K Y51H4A.14 Y51H4A.14 Putative paralog of C. elegans C44B12.7 Y51H4A.15 Y51H4A.M;Y51H4A.15 Protein of unknown function Y51H4A.16 Y51H4A.N;Y51H4A.16 Protein of unknown function Y51H4A.17 Y51H4A.O;Y51H4A.17 Putative ortholog of C. elegans Y51H4A.Q gene product The Y51H4A.17 gene encodes a protein that may be involved in apoptosis. Y51H4A.18 Y51H4A.P;Y51H4A.18 Protein with moderate similarity to C. elegans Y51H4A.O gene product Y51H4A.19 Y51H4A.Q;Y51H4A.19 Putative ortholog of C. elegans Y51H4A.O gene product Y51H4A.2 Y51H4A.2 Protein of unknown function, putative paralog of C. elegans Y51H4A.B Y51H4A.20 Y51H4A.R;Y51H4A.20 Protein with strong similarity to C. elegans Y51H4A.O gene product Y51H4A.21 Y51H4A.21 Protein of unknown function, has strong similarity to C. elegans Y51H4A.S Y51H4A.22 Y51H4A.T;Y51H4A.22 Putative ortholog of C. elegans T08B6.5 gene product Y51H4A.23 Y51H4A.23 Protein of unknown function, putative paralog of C. elegans Y51H4A.U Y51H4A.24 Y51H4A.24 Protein of unknown function, putative paralog of C. elegans Y51H4A.V Y51H4A.25 Y51H4A.25 Putative paralog of C. elegans T28F3.9 Y51H4A.26 Y51H4A.26 Protein of unknown function Y51H4A.3 rho-1;RhoA;Y51H4A.3;CeRhoA GTP-binding protein of the rho family (ras superfamily), putative ortholog of H. sapiens ARHA and ARHC p21 ras-related rho (RhoA) Y51H4A.4 Y51H4A.C;Y51H4A.4 Protein with moderate similarity to C. elegans ces-2 gene product Y51H4A.5 Y51H4A.D;Y51H4A.5 Putative ortholog of C. elegans Y49E10.P gene product Y51H4A.6 Y51H4A.6 Protein of unknown function, has moderate similarity to C. elegans Y51H4A.E Y51H4A.7 Y51H4A.F;Y51H4A.7 Protein with strong similarity to bacterial urocanase Y51H4A.8 Y51H4A.H;Y51H4A.8 Putative ortholog of C. elegans B0513.7 gene product Y51H4A.9 Y51H4A.I;Y51H4A.9 Protein with strong similarity to C. elegans col-12 gene product Y51H7BM.1 Y51H7BM.1 Protein with strong similarity to C. elegans ZK250.6 gene product Y51H7BR.1 Y51H7BR.1 Protein of unknown function, putative paralog of C. elegans Y51H7BR.2 Y51H7BR.2 Y51H7BR.2 Protein of unknown function, putative paralog of C. elegans Y51H7BR.1 Y51H7BR.3 Y51H7BR.3 Protein of unknown function, has weak similarity to C. elegans K02E7.11 Y51H7BR.4 Y51H7BR.4 Protein of unknown function Y51H7BR.5 Y51H7BR.5 Protein of unknown function Y51H7BR.6 Y51H7BR.6 Protein of unknown function, has strong similarity to C. elegans R07B5.3 Y51H7BR.7 Y51H7BR.7 Protein of unknown function Y51H7C.1 Y51H7C.1 Putative ortholog of C. elegans H17B01.2 gene product Y51H7C.10 Y51H7C.10 Protein with strong similarity to C. elegans Y51H7C.H gene product Y51H7C.11 Y51H7C.11 Putative ortholog of C. elegans Y51H7C.G gene product Y51H7C.12 Y51H7C.12 Putative ortholog of C. elegans Y51H7C.F gene product Y51H7C.13 Y51H7C.13 Protein predicted to contain a glycosylphosphatidylinositol (GPI) lipid anchor Y51H7C.2 Y51H7C.2 Putative ortholog of C. elegans Y51H7C.R gene product Y51H7C.3 Y51H7C.3 Protein with strong similarity to C. elegans Y51H7C.Q gene product Y51H7C.4 Y51H7C.4 Putative ortholog of C. elegans Y51H7C.P gene product Y51H7C.5 Y51H7C.5 Protein with strong similarity to C. elegans Y51H7C.O gene product Y51H7C.6 Y51H7C.6 Putative ortholog of C. elegans Y51H7C.O gene product Y51H7C.7 Y51H7C.7 Putative ortholog of C. elegans Y51H7C.M gene product Y51H7C.8 Y51H7C.8 Protein with strong similarity to C. elegans Y51H7C.L gene product Y51H7C.9 Y51H7C.9 Putative ortholog of C. elegans Y51H7C.I gene product Y52B11A.1 Y52B11A.1 Protein of unknown function Y52B11A.10 Y52B11A.10 Protein containing a MIF4G (middle domain of eukaryotic initiation factor 4G) domain and an MA3 domain, has weak similarity to uncharacterized S. pombe Spac24c9.11p Y52B11A.2 Y52B11A.2 Member of the uncharacterized protein family UPF0029, has low similarity to S. cerevisiae Yih1p, which may function in general amino acid control response Uncharacterized protein family UPF0029 Y52B11A.3 Y52B11A.3 Protein containing a heme-binding domain, and an oxidoreductase FAD-binding domain, has low similarity to flavohemoprotein b5+b5R (human b5&b5R), which is an NAD(P)H oxidoreductase that functions in energy pathways and may act as an oxygen sensor Heme-binding domain in cytochrome b5 and oxidoreductases Y52B11A.4 Y52B11A.4 Protein of unknown function, has a region of low similarity to ras-related protein associated diabetes (mouse Rrad), which binds tropomyosin Y52B11A.5 Y52B11A.5 Protein containing a C-type lectin domain, which mediate calcium-dependent carbohydrate recognition, has moderate similarity to uncharacterized C. elegans Y18D10A.10 Y52B11A.7 Y52B11A.7 Putative ortholog of C. elegans W02B8.3 gene product Y52B11A.8 Y52B11A.8 Protein with moderate similarity to C. elegans B0478.3 gene product Y52B11A.9 Y52B11A.9 Protein of unknown function, has a region of high similarity to antigenic determinant of recA protein (mouse Kin), which is a zinc finger protein that binds bent DNA and plays a role in cell proliferation Y52B11B.1 Y52B11B.1 Protein of unknown function Y52B11C.1 Y52B11C.1 Protein of unknown function, has moderate similarity to a region of human PIGL, which is an N-acetylglucosaminylphosphatidylinositol deacetylase Y52D3.1 Y52D3.1 Putative serine/threonine protein kinase, has similarity to human STE20-like (p21-activated) protein kinases, has similarity to S. cerevisiae Ste20p and Nrk1p serine/threonine kinase Y52D5A.1 Y52D5A.1 Putative ortholog of C. elegans Y52D5A_42.A gene product Y52D5A.2 Y52D5A.2 Putative ortholog of C. elegans T25B9.5 gene product protein kinase Y52E8A.1 Y52E8A.1 Putative ortholog of C. elegans Y52E8A.E gene product Y52E8A.2 Y52E8A.2 Putative ortholog of C. elegans Y52E8A.D gene product Y52E8A.3 Y52E8A.3 Putative ortholog of C. elegans Y52E8A.C gene product Y52E8A.4 Y52E8A.4 Putative ortholog of C. elegans F31D5.1 gene product Y52E8A.5 Y52E8A.5 Putative ortholog of C. elegans B0478.2 gene product 7TM chemoreceptor, srw family Y53C10A.1 Y53C10A.1 Protein with strong similarity to C. elegans Y43F11A.6 gene product Y53C10A.13 Y53C10A.13 Protein of unknown function, putative paralog of C. elegans Y53C10A.F Y53C10A.14 Y53C10A.14 Protein of unknown function, putative paralog of C. elegans Y53C10A.F Y53C10A.2 Y53C10A.2 Protein of unknown function Y53C10A.3 Y53C10A.3 Protein with moderate similarity to C. elegans Y53C10A.12 gene product Y53C10A.4 Y53C10A.A;Y53C10A.4 Protein containing a RhoGAP (GTPase activator protein) domain, has a region of low similarity to a region of Ral-interacting protein 1 (mouse Rip1), which interacts with the activated form of Ral GTP binding protein and activates GTPases Rac1 and Cdc42 RhoGAP domain Y53C10A.5 Y53C10A.B;Y53C10A.5 Protein of unknown function Y53C10A.6 Y53C10A.C;Y53C10A.6 Protein of unknown function Y53C10A.E Y53C10A.7;Y53C10A.E Protein containing a DUF38 domain of unknown function and an F-box domain, which serve as a link between a target protein and a ubiquitin-conjugating enzyme, has low similarity to C. elegans FOG-2, which is required for the sexual identity of germ cells Y53C10A.G Y53C10A.9;Y53C10A.G Member of the ABC transporter family, which are involved intranslocation of a variety of compounds across biological membranes, has low similarity to C. elegans CED-7, which is involved in phagocytosis and apoptosis Y53C10A.H Y53C10A.10;Y53C10A.H Protein with strong similarity to C. elegans T27E7.1 gene product Y53C12A.1 wee-1.3;Y53C12A.1 Serine/threonine/tyrosine protein kinase with similarity to human, D. melanogaster, and S. cerevisiae tyrosine- and threonine-specific cdc-2 inhibitory kinases serine/threonine kinase Y53C12A.2 Y53C12A.2 Protein with high similarity to C. elegans GLT-2, which is a glutamate transporter, member of the sodium:dicarboxylate symporter family of membrane transporters excitatory amino acid transporter; glt-5 encodes an ortholog of glutamate/aspartate and neutral amino acid transporters. Y53C12A.3 Y53C12A.3 Protein of unknown function Y53C12A.4 Y53C12A.4 Protein with moderate similarity to S. cerevisiae Hym1p, which is required for sporulation, apical cell growth, and efficient cell separation Mouse MO25 protein like Y53C12A.6 Y53C12A.6 Protein of unknown function Y53C12B.1 Y53C12B.1 Member of the WD repeat protein family WD domain, G-beta repeats (4 domains) Y53C12B.2 Y53C12B.2 Putative ortholog of S. cerevisiae Yor145p, a protein of unknown function Y53C12B.3 nos-3;Y53C12B.3 Protein with weak similarity to D. melanogaster nanos over the zinc finger domain nos-3 encodes a homolog of Drosophila NANOS that physically interacts with FBF-1 (similar, though not orthologous, to Drosophila PUMILIO); NOS-3 is required in development of the hermaphrodite germ-line to promote the switch from sperm to oocyte production, perhaps by forming a complex with FBF-1 that controls fem-3 mRNA. Y53C12B.5 mab-3;Y53C12B.5;Y53C12B.5 Protein required for sex-specific production of yolk proteins and male tail development DM DNA binding domain Y53C12B.6 Y53C12B.6 Protein of unknown function, has low similarity to a region of C. elegans CUT-1, which is a cuticulin component Y53C12C.1 Y53C12C.1 Homeodomain transcription factor, only member of a proposed Cpax family, containing no PAI subdomain but an apparent C-terminal RED domain, having similarity over 346 amino acids to the D. melanogaster EYG (eyegone) homeodomain transcription factor required for salivary duct development 'Paired box' domain, Homeobox domain; Y53C12C.1 encodes a divergent paired-like homeodomain protein that does not belong to the Q50, K50, or S50 classes; it has no obvious function in mass RNAi assays. Y53F4A.2 Y53F4A.2 Protein of unknown function, has moderate similarity to C. elegans K08E7.4 Y53F4B.1 Y53F4B.B;Y53F4B.1 Protein containing two protein kinase domains Y53F4B.10 Y53F4B.M;Y53F4B.10 Protein with weak similarity to H. sapiens Hs.198760 (Homo sapiens mRNA for KIAA0845 protein, partial cds) Y53F4B.10 is orthologous to the human gene INSULIN (IRF4; OMIM:176730), which when mutated leads to disease. Y53F4B.11 Y53F4B.O;Y53F4B.11 Protein of unknown function, has a region of weak similarity to a region of solute carrier family 7 member 1 (rat Slc7a1), which mediates the transport of basic amino acids and acts as a receptor for ecotropic retroviruses Y53F4B.12 Y53F4B.P;Y53F4B.12 Member of the FtsJ-like methyltransferase family, which may bind RNA, contains a G-patch domain, which are found in RNA processing proteins, has high similarity to uncharacterized C. elegans Y53F4B.13 Y53F4B.13 Y53F4B.13 Putative ortholog of D. melanogaster CG6379 (CG6379 gene product) Y53F4B.14 Y53F4B.14 Protein with weak similarity to C. elegans Y53F4B.Q Y53F4B.15 Y53F4B.15 Putative paralog of C. elegans asc-1 asc-1 encodes a homolog of human activating signal cointegrator-1 and affects long-term survival and longivity in adults and daur larvae. Y53F4B.16 Y53F4B.16 Protein of unknown function, has strong similarity to C. elegans Y53F4B.17 Y53F4B.17 Y53F4B.17 Protein of unknown function, putative paralog of C. elegans Y53F4B.V Y53F4B.18 Y53F4B.W;Y53F4B.18 Protein of unknown function Y53F4B.19 Y53F4B.19 Protein of unknown function, has weak similarity to C. elegans T05D4.5 Y53F4B.2 Y53F4B.C;Y53F4B.2 Member of the GNS1 or SUR4 family of integral membrane proteins, has low similarity to polyunsaturated fatty acid (PUFA) elongase (C. elegans CEEl01), which contains the condensation activity required for fatty acid elongation The elo-9 gene encodes a paralog of elo-1 and elo-2, each of which encodes a polyunsaturated fatty acid (PUFA) elongase; elo-9 has no known function in vivo. Y53F4B.20 Y53F4B.20 Protein with strong similarity to C. elegans T12E12.6 Y53F4B.22 Y53F4B.22 Putative ortholog of S. cerevisiae ACT1 gene product (Actin, involved in cell polarization, endocytosis, and other cytoskeletal functions) actin-like protein Y53F4B.23 Y53F4B.23 Protein of unknown function Y53F4B.24 Y53F4B.24 Protein of unknown function, has moderate similarity to C. elegans F22G12.3 Y53F4B.25 Y53F4B.25 Protein of unknown function, has weak similarity to C. elegans Y39B6B.J Y53F4B.26 Y53F4B.26 Protein of unknown function, has strong similarity to C. elegans Y53F4B.7 Y53F4B.27 Y53F4B.27 Protein with weak similarity to C. elegans T21B6.3 (Protein with similarity in the C-terminal region to thrombospondins) Y53F4B.28 ptr-20;Y53F4B.28 Putative paralog of C. elegans T21H3.2 Y53F4B.3 Y53F4B.D;Y53F4B.3 Protein of unknown function Y53F4B.34 ZK546.8;Y53F4B.34 Member of the transposase family, which are required for excising and inserting mobile genetic elements, has very strong similarity to uncharacterized C. elegans Y37A1A.1 mariner transposase Y53F4B.37 Y53F4B.37 Putative ortholog of C. elegans Y32G9A.1 gene product glutathione S-transferase Y53F4B.39 Y53F4B.39 Protein with strong similarity to C. elegans Y53F4B.S gene product Y53F4B.4 Y53F4B.4 Member of an uncharacterized protein family Y53F4B.5 Y53F4B.H;Y53F4B.5 Protein of unknown function, has weak similarity to C. elegans Y48B6A.E Y53F4B.6 Y53F4B.I;Y53F4B.6 Protein with strong similarity to C. elegans Y53F4B.26 gene product Y53F4B.7 Y53F4B.7 Protein of unknown function, putative paralog of C. elegans ZK250.9 Y53F4B.8 Y53F4B.8 Protein of unknown function, has moderate similarity to C. elegans F53A2.1 Y53F4B.9 Y53F4B.N;Y53F4B.9 Protein with strong similarity to C. elegans Y51F10.4 gene product Y53G8AL.1 Y53G8AL.1 Putative ortholog of C. elegans Y53G8AL.C gene product Y53G8AL.2 Y53G8AL.2 Putative ortholog of C. elegans Y53G8AL.A gene product Y53G8AL.3 Y53G8AL.3 Putative ortholog of C. elegans Y53G8AL.A gene product Y53G8AM.8 Y53G8AM.8 Putative ortholog of C. elegans Y53G8AM.B gene product Y53G8AM.D Y53G8AM.7;Y53G8AM.D Protein of unknown function, has moderate similarity to C. elegans Y53G8A_2706.B Y53G8AM.E Y53G8AM.6;Y53G8AM.E Protein of unknown function, has weak similarity to C. elegans Y53G8AR.H Y53G8AM.F Y53G8AM.5;Y53G8AM.F Protein of unknown function, putative paralog of C. elegans T20D3.2 Y53G8AM.G Y53G8AM.4;Y53G8AM.G Protein of unknown function, has weak similarity to C. elegans Y4C6A.3 Y53G8AM.H Y53G8AM.3;Y53G8AM.H Protein of unknown function, has weak similarity to C. elegans Y74C10AL.B Y53G8AM.I Y53G8AM.2;Y53G8AM.I Protein of unknown function Y53G8AM.J Y53G8AM.1;Y53G8AM.J Putative paralog of C. elegans F38A1.2 (Member of the Tc3 Transposase protein family) Y53G8AR.1 Y53G8AR.1 Putative ortholog of C. elegans Y53G8AR.H gene product Y53G8AR.2 Y53G8AR.2 Putative ortholog of C. elegans Y53G8AR.G gene product Y53G8AR.3 Y53G8AR.3 Putative ortholog of C. elegans Y53G8AR.F gene product Y53G8AR.5 Y53G8AR.5 Putative ortholog of C. elegans Y53G8AR.E gene product Y53G8AR.6 Y53G8AR.6 Putative ortholog of C. elegans Y53G8AR.D gene product Y53G8AR.7 Y53G8AR.7 Putative ortholog of C. elegans Y53G8AR.C gene product Y53G8AR.8 Y53G8AR.8 Putative ortholog of C. elegans Y53G8AR.B gene product Y53G8AR.9 Y53G8AR.9 Putative ortholog of C. elegans Y53G8AR.A gene product Y53G8B.1 Y53G8B.1 Putative paralog of C. elegans Y71F9AL.5 Y53G8B.2 Y53G8B.2 Putative paralog of C. elegans Y53G8B_93.B Y53G8B.3 Y53G8B.3 Protein of unknown function, has strong similarity to C. elegans Y53G8B_93.A Y53G8B.4 Y53G8B.4 Protein with strong similarity to D. melanogaster CG12292 (CG12292 gene product) Y53G8B.5 Y53G8B.5 Protein of unknown function Y53H1A.1 Y53H1A.1 Putative paralog of C. elegans Y53H1A.C Y53H1A.2 Y53H1A.2 Protein with moderate similarity to C. elegans T08D10.1 (Protein with similarity over a short region to transcription factors including S. cerevisiae Hap2p and human NFYA) Y53H1A.3 Y53H1A.3 Protein of unknown function, putative paralog of C. elegans Y53H1A.B Y53H1B.1 Y53H1B.1 Putative paralog of C. elegans Y38C1AA.F cuticlin Y53H1B.2 Y53H1B.2 Protein of unknown function, has weak similarity to C. elegans Y39A1A.7 Y53H1B.4 Y53H1B.4 Protein of unknown function, has weak similarity to C. elegans F47F6.4 Y53H1B.5 Y53H1B.5 Protein of unknown function, has weak similarity to C. elegans C18D4.7 Y53H1B.6 Y53H1B.6 Putative paralog of C. elegans H25P06.4 cysteine protease Y53H1C.1 Y53H1C.1 Putative paralog of C. elegans T13A10.10 Y53H1C.2 Y53H1C.2 Putative paralog of C. elegans Y53H1C.C Y53H1C.3 Y53H1C.3 Protein of unknown function, putative paralog of C. elegans Y53H1C.D Y54B9A.A Y54B9A.1;Y54B9A.A Protein with strong similarity to C. elegans Y105C5.U gene product Y54C5A.1 Y54C5A.1 Protein of unknown function Y54C5B.1 mut-2;Y54C5B.1 Protein of unknown function, has high similarity to uncharacterized C. elegans M116.3 transposase Y54E10A.1 Y54E10A.1 Protein of unknown function Y54E10A.10 Y54E10A.10 Protein with strong similarity to D. melanogaster CG7993 (CG7993 gene product) Y54E10A.11 Y54E10A.11 Protein with strong similarity to H. sapiens KIAA0714 (KIAA0714 protein) Y54E10A.12 Y54E10A.12 Protein of unknown function, has strong similarity to C. elegans F57B10.4 Y54E10A.13 Y54E10A.13 Putative ortholog of C. elegans Y54E10A_156.C gene product Y54E10A.14 Y54E10A.14 Protein with weak similarity to D. melanogaster CG8972 (CG8972 gene product) Y54E10A.15 Y54E10A.15 Protein with weak similarity to D. melanogaster CG8171 (CG8171 gene product) Y54E10A.16 Y54E10A.16 Protein of unknown function Y54E10A.17 Y54E10A.17 Protein with strong similarity to C. elegans Y73F4A.3 gene product Y54E10A.18 Y54E10A.18 Protein of unknown function Y54E10A.2 Y54E10A.2 Protein of unknown function Y54E10A.4 fog-1;Y54E10A_156.D;Y54E10A.4 Putative CPEB RNA binding protein required for the development of male germ cells The fog-1 gene encodes a cytoplasmic polyadenylation element binding (CPEB) protein that is required for specification of the sperm fate. Y54E10A.5 Y54E10A.5 Protein with moderate similarity to D. melanogaster CG17347 (CG17347 gene product) Y54E10A.6 Y54E10A.6 Protein with moderate similarity to S. cerevisiae FRS1 (Phenylalanyl-tRNA synthetase, alpha subunit, cytoplasmic) Y54E10A.7 Y54E10A.7 Protein with weak similarity to D. melanogaster CG13880 (CG13880 gene product) Y54E10A.9 Y54E10A.9 Putative ortholog of S. cerevisiae DBP1 gene product (ATP-dependent RNA helicase of the DEAD box family) helicase Y54E10A_156.C Y54E10A_156.C Putative ortholog of C. elegans Y54E10A.13 gene product Y54E10BL.1 Y54E10BL.1 Protein of unknown function Y54E10BL.2 Y54E10BL.2 Putative paralog of C. elegans col-14 collagen Y54E10BL.3 Y54E10BL.3 Protein of unknown function Y54E10BL.4 Y54E10BL.4 Putative ortholog of D. melanogaster CG8286 (CG8286 gene product) This gene encodes a protein containing a DnaJ ('J') domain. Y54E10BL.5 Y54E10BL.5 Protein with weak similarity to D. melanogaster CG11455 (CG11455 gene product) Y54E10BL.6 mex-2;Y54E10BL.6 Protein with very strong similarity to C. elegans mek-2, which is a serine-threonine protein kinase required for meiosis and vulval induction, contains a protein kinase domain protein kinase Y54E10BR.8 Y54E10BR.8 Putative ortholog of C. elegans Y54E10BR.A gene product Y54E10BR.B mod-5;Y54E10BR.7;Y54E10BR.B Serotonin reuptake transporter, SERT Y54E10BR.C Y54E10BR.6;Y54E10BR.C Protein with strong similarity to H. sapiens POLR2G (polymerase (RNA) II (DNA directed) polypeptide G) Y54E10BR.D Y54E10BR.5;Y54E10BR.D Protein with strong similarity to D. melanogaster BcDNA:GM04682 (Protein of unknown function) Y54E10BR.G Y54E10BR.4;Y54E10BR.G Putative ortholog of C. elegans Y54E10BR.F gene product Y54E10BR.H Y54E10BR.3;Y54E10BR.H Protein with weak similarity to C. elegans EEED8.9 (Serine/threonine protein kinase with weak similarity to protein kinases of human, D. melanogaster, and S. cerevisiae) Y54E10BR.I Y54E10BR.2;Y54E10BR.I Protein with moderate similarity to S. cerevisiae ARL3 (ADP-ribosylation factor-like protein, member of the arf-sar family in the ras superfamily) Y54E10BR.J Y54E10BR.1;Y54E10BR.J Putative ortholog of H. sapiens MDC4 (endoplasmic reticulum membrane protein) Y54E10B_152.C mek-2;let-537;Y54E10B_152.B;Y54E10B_152.C Serine/threonine protein kinase with strong similarity to human and D. melanogaster MAP kinase kinases (MEK kinases), required for meiosis and vulval induction Y54E2A.1 Y54E2A.1 Member of the rhodopsin family of G-protein coupled receptors (GPCR), has a region of low similarity to cholecystokinin A receptor (human CCKAR), which stimulates phospholipase C, regulates secretion and is associated with obesity and diabetes 7 transmembrane receptor (rhodopsin family) Y54E2A.10 Y54E2A.10 Protein of unknown function Y54E2A.11 Y54E2A.11 Putative subunit of translation initiation factor eIF3 Y54E2A.12 Y54E2A.12 Protein containing a TBC domain, which may be GTPase activators of Rab-like small GTPases Y54E2A.2 Y54E2A.2 Protein of unknown function, has weak similarity to human Hs.10116 gene product Y54E2A.3 Y54E2A.3;2P40 Protein with weak similarity to H. sapiens Hs.90415 (Homo sapiens TACC2 protein (TACC2) mRNA, partial cds) tac-1 encodes a novel protein that is a member of the transforming acidic coiled-coil (TACC) protein family whose members contain highly conserved C-terminal coiled-coil domains; TAC-1 is required during early embryogenesis for pronuclear migration and maintenance of microtubule stability and later, may also play roles in locomotion and establishment of normal body morphology; TAC-1 mutually stabilizes, and interacts in vivo with, ZYG-9, a microtubule-associated protein (MAP) that is also required for pronuclear migration; in vitro, TAC-1 interacts with ZYG-8, a kinase domain-containing MAP required for proper spindle positioning during anaphase of the first embryonic cell division; TAC-1 localizes primarily to spindle poles during mitosis. Y54E2A.4 Y54E2A.4 Protein of unknown function Y54E2A.5 Y54E2A.5 Protein of unknown function Y54E2A.6 Y54E2A.6 Member of the DEAD or DEAH box ATP-dependent RNA helicase family, contains two helicase conserved C-terminal domains and two Sec63 domains, has moderate similarity to S. cerevisiae Slh1p, which represses translation of mRNA that lacks poly(A)+ tail Helicases conserved C-terminal domain Y54E2A.7 Y54E2A.7 Protein of unknown function Y54E2A.8 Y54E2A.8 Protein of unknown function, has weak similarity to C. elegans C11G6.1 Y54E2A.9 Y54E2A.9 Protein of unknown function, has moderate similarity to uncharacterized C. elegans T02H6.9 Y54E5A.1 Y54E5A.1 Protein with high similarity to degenerative spermatocyte homolog (human DEGS), which regulates the biosynthesis of the epidermal growth factor receptor (human EGFR) Y54E5A.2 Y54E5A.2 Protein of unknown function Y54E5A.3 Y54E5A.3 Protein of unknown function Y54E5A.4 Y54E5A.4 Protein of unknown function, has a region of moderate similarity to a region of S. cerevisiae Nup100p, which is a nuclear pore protein (nucleoporin) that may be involved in binding and translocation of proteins during nucleocytoplasmic transport Y54E5A.5 Y54E5A.5 Protein of unknown function, has moderate similarity to uncharacterized C. albicans Orf6.8403p Y54E5A.6 Y54E5A.6 Member of the uncharacterized protein family UPF0034, contains a double-stranded RNA binding domain, has moderate similarity to uncharacterized human FLJ20399 Uncharacterized protein family UPF0034, Double-stranded RNA binding motif; This gene encodes a protein predicted by Eisenberg and coworkers, with 52% accuracy, to be mitochondrial. Y54E5A.7 Y54E5A.7 Protein containing a SPRY (SPla and RYanodine Receptor) domain, has a region of moderate similarity to a region of ran-binding protein 9 (human RANBP9), which binds human RAN and serves in microtubule nucleation and centrosomal function Domain in SPla and the ryanodine Receptor. Y54E5A.8 Y54E5A.8 Protein of unknown function Y54E5B.1 smp-1;Ce-Sema-1a;cesema;Y54E5B.1 Putative semaphorin, a class of repulsive axon guidance molecules identified in many organims Y54E5B.2 Y54E5B.2 Protein containing six WD domains (WD-40 repeat), which may mediate protein-protein interactions Y54E5B.3 CeMed7;Y54E5B.3 Component of the Mediator complex required for transcriptional regulation of certain genes let-49 encodes a putative mediator complex subunit zygotically required for postembryonic development and viability past larval stages, while being maternally required for germline and embryonic development; LET-49 is an ortholog of human CRSP9 (OMIM:605045) and of S. cerevisiae Med7p; Med7p is a component of a mediator complex that serves as a transcriptional coactivator, while CRSP9 mediates transcriptional activation by Sp1. Y54E5B.4 Y54E5B.4 Member of the ubiquitin-conjugating enzyme (E2) family, which catalyze the covalent attachment of ubiquitin to target proteins, has low similarity to ubiquitin-conjugating (E2) enzyme (S. cerevisiae Ubc4p), which catalyzes degradation of abnormal proteins Ubiquitin-conjugating enzymes Y54F10AL.2 Y54F10AL.2 Protein of unknown function est-1 encodes two isoforms of a putative telomerase subunit orthologous to human EST1A (KIAA0732), Drosophila CG6369, and (more distantly) to S. cerevisiae EST1; EST-1A/B proteins have, from their N- to C-termini, an EST domain, one and a half tetratricopeptide repeats (TPRs), and a PilT amino-terminal (PIN) domain; the first two domains are shared with both metazoan and fungal EST1 orthologs, while the PIN domain is found only in metazoan EST1s; although it seems likely to be required for long-term maintenance of the germline (perhaps by recruiting telomerase to telomeres), est-1 has no obvious function in mass RNAi assays. Y54F10AL.A Y54F10AL.3;Y54F10AL.A Protein with moderate similarity to H. sapiens KIAA0732 (Homo sapiens mRNA for KIAA0732 protein, partial cds) Y54F10AL.BB Y54F10AL.1;Y54F10AL.BA;Y54F10AL.BB Protein with strong similarity to C. elegans Y54F10AL.B gene product Y54F10AM.11 Y54F10AM.11 Putative ortholog of C. elegans Y54F10AM.A gene product Y54F10AM.2 feh-1;Y54F10AM.2 Putative ortholog of C. elegans Y54F10AM.L gene product feh-1 encodes the single C. elegans member of the Fe65 protein family that affects embryonic and larval viability and pharyngeal pumping; the PTB2 domain binds to cytosolic domain of C. elegans APL-1 in vitro; expressed in the neuromuscular structures of the pharynx and in a subset of neurons. Y54F10AM.4 Y54F10AM.4 Putative ortholog of C. elegans Y54F10AM.J gene product ceh-44 encodes at least three proteins via alternative splicing; the CEH-44A protein is an ortholog of the CUX class of CUT homeodomain proteins, expressed in early embryos (mostly anterior in the comma stage), in the larval nerve ring and the adult gonad; the CUX class includes Drosophila CUT, human CUTL1 and human CUTL2; ceh-44 is a complex gene, in which two alternatively spliced protein products completely lack the homeodomain, and instead resemble vertebrate CASP proteins; CASP proteins are also found in plants and fungi (though not associated with homeodomains); like its orthologs, CEH-44A has three N-terminal cut domains in addition to a C-terminal CUT homeodomain; the cut domain may be a compact DNA-binding domain composed of alpha helices. Y54F10AM.C Y54F10AM.10;Y54F10AM.C Protein of unknown function Y54F10AM.D Y54F10AM.9;Y54F10AM.D Protein of unknown function Y54F10AM.G Y54F10AM.7;Y54F10AM.G Protein with moderate similarity to C. elegans C53D5_1638.C gene product Y54F10AM.H Y54F10AM.6;Y54F10AM.H Protein with strong similarity to C. elegans T19C3.2 gene product Y54F10AM.I Y54F10AM.5;Y54F10AM.I Protein of unknown function Y54F10AM.K Y54F10AM.3;Y54F10AM.K Protein of unknown function Y54F10AM.M Y54F10AM.1;Y54F10AM.M Protein with strong similarity to C. elegans fax-1 gene product Y54F10AR.A Y54F10AR.1;Y54F10AR.A Putative ortholog of C. elegans Y71G12B.17 gene product Y54F10AR.B Y54F10AR.2;Y54F10AR.B Protein of unknown function Y54F10BM.1 Y54F10BM.1 Protein with moderate similarity to C. elegans T23F11.1 gene product Y54F10BM.10 Y54F10BM.10 Putative ortholog of C. elegans T12B5.11 gene product Y54F10BM.11 Y54F10BM.11 Putative ortholog of C. elegans T28A11.21 gene product Y54F10BM.12 Y54F10BM.12 Protein of unknown function Y54F10BM.13 Y54F10BM.13 Protein with moderate similarity to C. elegans lip-1 gene product Y54F10BM.2 Y54F10BM.2 Protein of unknown function Y54F10BM.3 Y54F10BM.3 Protein with moderate similarity to C. elegans F55F8.7 gene product Y54F10BM.4 Y54F10BM.4 Putative ortholog of C. elegans F52D2.1 gene product Y54F10BM.5 Y54F10BM.5 Protein with strong similarity to C. elegans T12B5.3 gene product Y54F10BM.6 Y54F10BM.6 Protein with moderate similarity to C. elegans F40G9.12 gene product Y54F10BM.7 Y54F10BM.7 Putative ortholog of C. elegans F52D2.1 gene product Y54F10BM.9 Y54F10BM.9 Putative ortholog of C. elegans Y54F10BM.8 gene product Y54F10BR.1 Y54F10BR.1 Protein of unknown function Y54G11A.1 Y54G11A.1 Protein of unknown function Y54G11A.10 lin-7;Y54G11A.10 Component of the LIN-2, LIN-7, LIN-10 cell junction complex required for localization of the tyrosine kinase receptor LET-23 PDZ domain (Also known as DHR or GLGF).; lin-7 encodes a protein that contains a PDZ domain and an L27 domain, two protein interaction domains that likely serve as organizational centers for large macromolecular complexes in polarized cells; LIN-7 is required for proper basolateral localization of the LET-23/EGF receptor in vulval epithelial cells, and along with LIN-2 and LIN-10, forms a protein complex that likely mediates this asymmetric localization with LIN-7 simultaneously binding to the C-terminus of LET-23 and an internal region of LIN-2; a LIN-7 translational reporter fusion indicates that LIN-7 is expressed at intestinal cell junctions; expression in vulval epithelial cells is detected only upon overexpression via heat shock, and reveals localization primarily at the lateral cell junctions of the vulval precursor cells P5.p and P6.p. Y54G11A.11 Y54G11A.11 Protein of unknown function Y54G11A.12 Y54G11A.12 Putative ortholog of C. elegans Y40D12A.3 gene product Y54G11A.2 Y54G11A.2 Protein with weak similarity to C. elegans F43C1.3 gene product Y54G11A.3 Y54G11A.3 Protein of unknown function, putative DEAD/DEAH box helicase DEAD/DEAH box helicase ; Helicases conserved C-terminal domain Y54G11A.4 Y54G11A.4 Putative ortholog of C. elegans Y54G11A.7 gene product Y54G11A.5 ctl-2;cat1;CAT;Y54G11A.5 Peroxisomal catalase Catalase; ctl-2 encodes a peroxisomal catalase, whose mRNA abundance decreases as animals age; ctl-2 is orthologous to human CATALASE (OMIM:115500, mutated in acatalasemia). Y54G11A.6 Y54G11A.6 Protein of unknown function, putative catalase catalase; ctl-1 encodes a cytoplasmic catalase. Y54G11A.7 Y54G11A.7 Putative ortholog of C. elegans Y54G11A.4 gene product Y54G11A.8 Y54G11A.8 Putative ortholog of C. elegans B0513.7 gene product Y54G11A.9 Y54G11A.9 Protein of unknown function Y54G11B.1 Y54G11B.1 Protein of unknown function, has moderate similarity to uncharacterized C. elegans D1069.4 Y54G2A.1 Y54G2A.1 Putative ortholog of C. elegans lin-22 gene product Y54G2A.11 Y54G2A.11 Putative ortholog of C. elegans Y94H6A_142.K gene product Y54G2A.17 Y54G2A.17 Putative ortholog of C. elegans Y94H6A_148.P gene product Y54G2A.2 Y54G2A.2 Putative ortholog of C. elegans Y94H6A_1.A gene product Y54G2A.3 Y54G2A.3 Putative ortholog of C. elegans Y94H6A_144.B gene product Y54G2A.31 Y54G2A.31 Protein with strong similarity to C. elegans let-70 gene product Y54G2A.32 Y54G2A.32 Putative ortholog of C. elegans Y94H6A_1.D gene product Y54G2A.33 Y54G2A.33 Putative ortholog of C. elegans F38A1.1 gene product Y54G2A.34 Y54G2A.34 Protein of unknown function Y54G2A.4 Y54G2A.4 Putative ortholog of C. elegans Y94H6A_148.V gene product Y54G2A.5 Y54G2A.5 Putative ortholog of C. elegans Y94H6A_148.Q gene product Y54G2A.7 Y54G2A.7 Putative ortholog of C. elegans Y94H6A_151.H gene product Y54G2A.8 Y54G2A.8 Putative ortholog of C. elegans Y94H6A_151.H gene product Y54G2A.9 Y54G2A.9 Putative ortholog of C. elegans Y94H6A_151.E gene product Y54G2A.A Y54G2A.30;Y94H6A_136.A;Y54G2A.A Protein containing a HECT domain, which may confer ubiquitin-protein ligase activity, has a region of moderate similarity to a region of S. cerevisiae Tom1p, which is required for the G2/M transition Y54G2A.B Y54G2A.29;Y94H6A_136.B;Y54G2A.B Protein of unknown function Y54G2A.C Y54G2A.28;Y54G2A.C Protein of unknown function, putative paralog of C. elegans Y94H6A_144.A Y54G2A.D Y54G2A.27;Y54G2A.D Protein of unknown function Y54G2A.F Y94H6A_148.A;Y54G2A.F Protein with strong similarity to C. elegans Y54G2A.26 gene product Y54G2A.G Y94H6A_148.B;Y54G2A.G Putative ortholog of C. elegans Y54G2A.26 gene product Y54G2A.H Y54G2A.26;Y94H6A_148.C;Y54G2A.H Putative ortholog of C. elegans Y94H6A_148.B gene product Y54G2A.I Y94H6A_148.D;Y54G2A.I Protein containing six immunoglobulin (Ig) domains, has low similarity to a region of close homologue of L1 (mouse Chl1), which is a cell adhesion molecule that promotes neurite outgrowth Y54G2A.J Y94H6A_148.E;Y54G2A.J Putative ortholog of C. elegans Y54G2A.25 gene product Y54G2A.K Y94H6A_148.F;Y54G2A.K Protein containing three fibronectin type III domains, which are involved in cell surface binding, has a region of moderate similarity to a region of L1 cell adhesion molecule (human L1CAM), which causes X-linked CRASH syndrome upon gene mutation Y54G2A.L Y54G2A.25;Y94H6A_148.G;Y54G2A.L Protein containing 10 immunoglobulin (Ig) domains, which may mediate protein-protein and protein-ligand interactions, and eight fibronectin type III domains, which mediate cell surface binding, has low similarity to L1 cell adhesion molecule (human L1CAM) Y54G2A.M Y54G2A.24;Y94H6A_148.H;Y54G2A.M Member of the serine or threonine protein phosphatase family, has low similarity to protein phosphatase 2 catalytic subunit alpha (rat Ppp2ca), which is involved in regulating diverse cellular processes via protein phosphorylation Y54G2A.N Y94H6A_148.I;Y54G2A.N Protein of unknown function Y54G2A.O Y54G2A.23;Y94H6A_148.J;Y54G2A.O Protein of unknown function Y54G2A.P Y54G2A.22;Y94H6A_148.K;Y54G2A.P Protein containing an F-box domain, which serve as a link between a target protein and a ubiquitin-conjugating enzyme, has high similarity to uncharacterized C. elegans M02B7.1 Y54G2A.Q Y54G2A.21;Y94H6A_148.L;Y54G2A.Q Putative ortholog of C. elegans F57G4.2 gene product Y54G2A.R Y54G2A.20;Y94H6A_148.M;Y54G2A.R Protein containing a C2H2 type zinc finger domain, which bind nucleic acids, has moderate similarity to uncharacterized C. elegans F52C6.14 Y54G2A.S Y54G2A.19;Y94H6A_148.N;Y54G2A.S Protein of unknown function, has weak similarity to C. elegans H11L12.1 Y54G2A.T Y54G2A.18;Y94H6A_148.O;Y54G2A.T;4D656 Protein of unknown function, has moderate similarity to B-cell receptor-associated protein 31 (human DXS1357E), which is a BCL2 binding protein that associates with membrane IgD and membrane IgM and may be involved in induction of apoptosis Y54G2A.V Y54G2A.16;Y94H6A_151.A;Y54G2A.V Protein of unknown function Y54G2A.W Y54G2A.15;Y94H6A_151.B;Y54G2A.W Protein of unknown function, has moderate similarity to C. elegans C33C12.4; may be anchored to the membrane of a secretory vesicle or the Golgi apparatus Y54G2A.X Y54G2A.14;Y94H6A_151.C;Y54G2A.X Protein containing a C-type lectin domain, which mediate calcium-dependent carbohydrate recognition, has moderate similarity to uncharacterized C. elegans F15E11.9 Y54G2A.Y Y54G2A.13;Y94H6A_151.D;Y54G2A.Y Protein with strong similarity to C. elegans Y69A2AR.12 gene product Y54G2A.Z Y54G2A.12;Y94H6A_142.H;Y54G2A.Z Putative ortholog of C. elegans F49D11.1 gene product Y54G9A.1 Y54G9A.1 Protein of unknown function Y54G9A.2 Y54G9A.2 Protein of unknown function Y54G9A.3 Y54G9A.3 Protein with high similarity to potassium voltage-gated channel (KQT-like subfamily) member 1 (human KCNQ1), which is associated with cardiac arrhythmia and deafness syndromes, member of the ion transport family, contains an IQ calmodulin-binding domain Ion transport proteins; The kqt-3 gene encodes a homolog of human KVLQT1, which when mutated leads to type 1 long QT syndrome (OMIM:192500). Y54G9A.4 Y54G9A.4 Member of the ZIP zinc transporter family, which may be metal transporters, has low similarity to zinc interacting protein 2 (human SLC39A2), which plays a role in the uptake of zinc and possibly other metal ions and may also be involved in apoptosis Y54G9A.5 Y54G9A.5 Protein of unknown function Y54G9A.6 Y54G9A.6 Member of the nuclear pore Gle2p-like protein family WD domain, G-beta repeat (2 domains) Y54G9A.7 Y54G9A.7;2O16 Protein of unknown function Y54H5A.1 Y54H5A.1 Putative ortholog of D. melanogaster CG12792 (CG12792 gene product) Y54H5A.2 Y54H5A.2 Putative ortholog of C. elegans Y54HA.2 gene product Y54H5A.3 Y54H5A.3 Protein with strong similarity to D. melanogaster CG2931 (CG2931 gene product) Y54H5A.4 Y54H5A.4 Protein with strong similarity to H. sapiens NARF (nuclear prelamin A recognition factor) Y55B1AL.1 Y55B1AL.1 Putative ortholog of C. elegans Y55B1AL.C gene product Y55B1AL.2 Y55B1AL.2 Protein with strong similarity to C. elegans Y55B1AL.B gene product The Y55B1AL.2 gene encodes a small protein that is of ancient origin, and thus is presumably important to eukaryotic life; it is homologous to YDR079C-A (also known as NDR019C) in S. cerevisiae, and has homologs in humans, plants, and Schizosaccharomyces pombe. Y55B1AL.3 Y55B1AL.3 Putative ortholog of C. elegans Y55B1AL.A gene product Y55B1AR.1 Y55B1AR.1 Protein with weak similarity to C. elegans W09H1.6 (Galactoside-binding lectin) lec-6 encodes a 'proto' type galectin (beta-galactosyl-binding lectin) containing a single carbohydrate recognition domain; by homology, LEC-6 may play roles in cell adhesion and aggregation, proliferation, or programmed cell death, but as loss of lec-6 activity via large-scale RNAi screens does not result in obvious abnormalities, the precise role of LEC-6 in C. elegans development and/or behavior is not yet known; in vitro, LEC-6 can interact with several types of blood group precursor oligosaccharides and gangliosides. Y55B1AR.3 Y55B1AR.3 Protein of unknown function, putative paralog of C. elegans Y55B1AR.4 Y55B1AR.4 Y55B1AR.4 Protein of unknown function, putative paralog of C. elegans Y55B1AR.3 Y55B1BL.1 Y55B1BL.1 Putative ortholog of C. elegans Y55B1BL.A gene product Y55B1BM.1 Y55B1BM.1 Putative ortholog of C. elegans Y55B1B_119.H gene product Y55B1BR.1 Y55B1BR.1 Protein of unknown function, putative paralog of C. elegans Y55B1BR.2 Y55B1BR.2 Y55B1BR.2 Protein of unknown function, putative paralog of C. elegans Y55B1BR.1 Y55B1BR.3 Y55B1BR.3 Putative paralog of C. elegans T10F2.3 Y55B1BR.4 Y55B1BR.4 Protein with strong similarity to C. elegans lin-2 (Component of the LIN-2, LIN-7, LIN-10 cell junction complex, involved in vulval development, probable ortholog of human and rat CASK proteins (putative scaffold proteins of the cytoskeletal membrane involved in signal transduction coordination)) Y55D5A.1 Y55D5A.1 Putative ortholog of C. elegans Y55D5A.I gene product Y55D5A.2 Y55D5A.2 Putative ortholog of C. elegans Y55D5A.G gene product Y55D5A.3 Y55D5A.3 Protein with strong similarity to C. elegans K11D2.2 gene product Y55D5A.6 Y55D5A.6 Putative ortholog of C. elegans Y55D5A.7 gene product Y55D5A.E Y55D5A.e Putative ortholog of C. elegans Y55D5A.4 gene product Y55D5A.F Y55D5A.4;Y55D5A.F Putative ortholog of C. elegans Y55D5A.e gene product Y55D5A_392.A daf-2;Y55D5A.5;Y55D5A.E;Y55D5A_391.B;Y55D5A_392.A Insulin/IGF-1 tyrosine-kinase receptor homolog involved in control of multiple processes including dauer larva formation, reproductive development, longevity, fertility, thermotolerance, embryonic viability and adult motility Y55D9A.1 Y55D9A.1 Protein containing two Sec7 domains, which are ARF family GTPase guanine nucleotide exchange factors, and two pleckstrin homology (PH) domains, which mediate protein-protein and protein-lipid interactions, has a region of low similarity to mouse Pscd3 Sec7 domain Y55D9A.2 Y55D9A.2 Protein containing four G-patch domains, which are found in RNA processing proteins, has a region of low similarity to a region of rat D83948, which is an S1-1 protein from liver that is an RNA-binding protein Y55F3AL.1 plx-1;Y55F3AL.1 Putative ortholog of D. melanogaster plexA (plexin A) Y55F3AM.1 Y55F3AM.1 Possible mitochondrial ribosomal small subunit protein Y55F3AM.10 Y55F3AM.10 Protein of unknown function Y55F3AM.11 Y55F3AM.11 Protein of unknown function, putative paralog of C. elegans Y39F10A.3 Y55F3AM.12 Y55F3AM.12 Protein with moderate similarity to D. melanogaster CG11183 (CG11183 gene product) Y55F3AM.13 Y55F3AM.13 Protein with weak similarity to C. elegans unc-89, a muscle cell protein of the immunoglobulin-like protein family that is required for coordinated locomotion Y55F3AM.14 Y55F3AM.14 Protein with strong similarity to H. sapiens DKFZP572C163 (DKFZP572C163 protein) Y55F3AM.15 Y55F3AM.15 Protein with strong similarity to D. melanogaster CH4 (COP9 complex homolog subunit 4) csn-4 encodes a protein with similarity to human COP9 proteasome subunit 4. Y55F3AM.2 Y55F3AM.2 Putative paralog of C. elegans C44B12.4 7TM chemoreceptor, srx family Y55F3AM.3 Y55F3AM.3 Protein of unknown function that is similar to a number of RNA binding proteins Y55F3AM.4 Y55F3AM.4 Protein with moderate similarity to S. cerevisiae AUT1 (Protein involved in autophagocytosis during starvation) Y55F3AM.5 Y55F3AM.5 Protein of unknown function Y55F3AM.6 Y55F3AM.6 Protein with strong similarity to H. sapiens HSPC070 (HSPC070 protein) Y55F3AM.7 Y55F3AM.7 Protein with strong similarity to H. sapiens EGR1 (early growth response 1) Y55F3AM.8 Y55F3AM.8 Protein with moderate similarity to D. melanogaster CG11110 (CG11110 gene product) Y55F3AM.9 Y55F3AM.9 Protein with weak similarity to S. cerevisiae YPL191C Y55F3AR.1 Y55F3AR.1 Protein of unknown function Y55F3AR.2 Y55F3AR.2 Putative paralog of C. elegans Y54E10A.3 Y55F3AR.3 Y55F3AR.3 Putative ortholog of S. cerevisiae CCT8 gene product (Component of Chaperonin-containing T-complex) Y55F3BL.1 Y55F3BL.1 Possible mitochondrial large subunit protein Y55F3BL.2 Y55F3BL.2 Protein with moderate similarity to H. sapiens KIAA0062 (KIAA0062 protein) Y55F3BL.3 Y55F3BL.3 Protein with weak similarity to H. sapiens KIAA0062 (KIAA0062 protein) Y55F3BR.1 Y55F3BR.1 Putative ortholog of C. elegans C44C8.5 gene product Y55F3BR.8 Y55F3BR.8 Putative ortholog of C. elegans Y55F3BR.c gene product Y55F3BR.C Y55F3BR.c Putative ortholog of C. elegans Y55F3BR.8 gene product Y55F3BR.E Y55F3BR.7;Y55F3BR.E Protein of unknown function Y55F3BR.F Y55F3BR.6;Y55F3BR.F Protein with moderate similarity to C. elegans F52E1.7 gene product Y55F3BR.G Y55F3BR.5;Y55F3BR.G Protein with weak similarity to C. elegans C32D5.1 gene product Y55F3BR.J Y55F3BR.3;Y55F3BR.J Putative ortholog of C. elegans F30H5.3 gene product Y55F3BR.K Y55F3BR.2;Y55F3BR.K Putative ortholog of C. elegans F30H5.3 gene product Y55H10A.1 Y55H10A.1 Protein with weak similarity to H. sapiens ATP6S1 (ATPase, H+ transporting, lysosomal (vacuolar proton pump), subunit 1) cadherin Y55H10A.2 Y55H10A.2 Protein of unknown function, has strong similarity to uncharacterized C. elegans F42A6.1 Y56A3A.10 Y56A3A.10 Protein of unknown function, putative paralog of C. elegans Y56A3A.14 This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins. Y56A3A.11 Y56A3A.11 Protein of unknown function, putative paralog of C. elegans Y56A3A.K Y56A3A.13 nft-1;NitFhit;Y56A3A.V;Y56A3A.13 Protein with similarity to both nitrilase and FHIT (a tumor suppressor) from mammals, member of the Nit and NitFhit branch of the nitrilase superfamily, which also includes human NIT1 and NIT2, M. musculus Nit1 and Nit2, S. cerevisiae Nit2p and Nit3p and S. pombe SPBC651.02p The nft-1 gene encodes an ortholog of human FHIT, which when mutated is associated with head and neck cancers (OMIM:601153). Y56A3A.16 Y56A3A.N;Y56A3A.16 Protein with moderate similarity to C. elegans Y51H1A.1 gene product Y56A3A.18 Y56A3A.Q;Y56A3A.18 Protein with moderate similarity to human LOC51042, which has transcriptional repressor activity Y56A3A.19 Y56A3A.O;Y56A3A.19 Protein containing a phosphopantetheine attachment site domain, has moderate similarity to S. cerevisiae Acp1p, which is an acyl carrier protein that is a component of the mitochondrial type II fatty acid synthase acyl-carrier protein Y56A3A.20 ccf-1;ccaf1;Y56A3A.R;Y56A3A.20 Protein with high similarity to CCR4-NOT transcription complex subunit 7 (CCR4 associated factor, mouse Cnot7), which is a transcription factor that may negatively regulate cell proliferation a homolog of subunit 7 of CCR4-NOT transcription complex from S. cerevisiae. Y56A3A.27 top-3;TOP3;Y56A3A.Z;Y56A3A.27 Topoisomerase IIIalpha DNA topoisomerase III Y56A3A.28 Y56A3A.28 Protein with weak similarity to C. elegans C55B7.12 gene product Y56A3A.29 Y56A3A.29 Protein of unknown function Y56A3A.3 mif-1;Y56A3A.B;Y56A3A.3 Member of the macrophage migration inhibitory factor family, has moderate similarity to macrophage migration inhibitory factor (human MIF), which is a cytokine involved in monocyte migration and chemotaxis, T cell activation and delayed hypersensitivity Y56A3A.30 Y56A3A.30 Protein with weak similarity to C. elegans K06A9.1 gene product Y56A3A.31 Y56A3A.31 Protein of unknown function Y56A3A.32 Y56A3A.32 Putative ortholog of C. elegans C51G7.5 gene product Y56A3A.5 Y56A3A.I;Y56A3A.5 Member of the amidase family, which catalyze hydrolysis of amides, has a region of low similarity to fatty acid amide hydrolase (human FAAH), which degrades neuromodulatory fatty acid amides and is associated with Parkinson's disease Y56A3A.A Y56A3A.1;Y56A3A.A Protein of unknown function Y56A3A.C Y56A3A.2;Y56A3A.C Member of the sterol-regulatory element binding protein (SREBP) site 2 protease family, which cleave SREBP transcription factors, has low similarity to human MBTPS2, which is a membrane-bound metalloendoprotease that plays a role in cholesterol metabolism Y56A3A.D Y56A3A.4;Y56A3A.D Protein with weak similarity to human and S. cerevisiae TAF (TATA box-binding protein-associated factor) proteins Y56A3A.F Y56A3A.6;Y56A3A.F Protein with weak similarity to H. sapiens Hs.18192 (Homo sapiens Ser/Arg-related nuclear matrix protein (SRM160) mRNA, complete cds) Y56A3A.G Y56A3A.15;Y56A3A.G Protein containing an F-box domain, which serve as a link between a target protein and a ubiquitin-conjugating enzyme, has strong similarity to uncharacterized C. elegans Y56A3A.14 Y56A3A.H Y56A3A.9;Y56A3A.H Putative ortholog of C. elegans Y64G10.C gene product Y56A3A.L Y56A3A.12;Y56A3A.L Member of the amidase family, which catalyze hydrolysis of amides, has low similarity to fatty acid amide hydrolase (rat Faah), which is an integral membrane serine hydrolase that degrades neuromodulatory fatty acid amides Y56A3A.M Y56A3A.14;Y56A3A.M Protein containing an F-box domain, which serve as a link between a target protein and a ubiquitin-conjugating enzyme, has strong similarity to uncharacterized C. elegans Y56A3A.10 Y56A3A.P Y56A3A.17;Y56A3A.P Protein of unknown function Y56A3A.S Y56A3A.21;Y56A3A.S Protein with low similarity to signal sequence receptor delta (translocon-associated protein delta, human SSR4), which is putative subunit of the translocon-associated protein complex involved in the oxidative stress response Y56A3A.T Y56A3A.22;Y56A3A.T Putative ortholog of C. elegans Y56A3A.U gene product Y56A3A.Y Y56A3A.7;Y56A3A.Y Protein contains a putative coiled-coil domain, has weak similarity to C. elegans unc-54 (Sarcomeric Myosin Heavy Chain, major component of thick filaments in body-wall muscle) Y57A10A.1 Y57A10A.1 Putative paralog of C. elegans Y57A10A.A Y57A10A.10 Y57A10A.Y;Y57A10A.10 Protein of unknown function, has very strong similarity to uncharacterized C. elegans Y57A10A.9 Y57A10A.13 Y57A10A.13 Putative paralog of C. elegans Y57A10A.K Y57A10A.14 Y57A10A.L;Y57A10A.14 Protein of unknown function Y57A10A.15 Y57A10A.15 Putative ortholog of D. melanogaster tam (Protein of unknown function) Y57A10A.15 is orthologous to the human gene MITOCHONDRIAL DNA POLYMERASE GAMMA (POLG; OMIM:174763), which when mutated leads to disease. Y57A10A.16 Y57A10A.N;Y57A10A.16 Protein with low similarity to DNA polymerase gamma (human POLG), which is the catalytic subunit of mitochondrial DNA polymerase required for mitochondrial DNA replication and is associated with progressive external ophthalmoplegia Y57A10A.18 Y57A10A.18 Putative paralog of C. elegans Y57A10A.Q The protein product of this gene is predicted to contain a glutamine/asparagine (Q/N)-rich ('prion') domain, by the algorithm of Michelitsch and Weissman (as of the WS77 release of WormBase, i.e., in wormpep77). Y57A10A.19 Y57A10A.19 Putative paralog of C. elegans Y57A10A.S Y57A10A.2 Y57A10A.2 Protein of unknown function, putative paralog of C. elegans Y57A10A.B Y57A10A.20 Y57A10A.20 Putative paralog of C. elegans Y57A10A.T Y57A10A.21 Y57A10A.21 Protein of unknown function, putative paralog of C. elegans Y57A10A.U rsr-2 encodes an SR-related protein, a likely homolog of human Srm300, that is predicted to be involved in pre-mRNA splicing and is required for larval viability. Y57A10A.22 Y57A10A.22 Protein of unknown function, has moderate similarity to C. elegans Y57A10A.V Y57A10A.23 Y57A10A.23 Putative paralog of C. elegans Y57A10A.W Y57A10A.24 Y57A10A.24 Protein of unknown function, putative paralog of C. elegans Y57A10A.X Y57A10A.25 Y57A10A.X;Y57A10A.25 Protein of unknown function, has very strong similarity to uncharacterized C. elegans Y57A10A.24 Y57A10A.26 Y57A10A.Z;Y57A10A.26 Protein of unknown function, has similarity in the N-terminal region to human poly(A)-specific ribonuclease PARN Y57A10A.27 Y57A10A.27 Protein of unknown function Y57A10A.28 Y57A10A.CC;Y57A10A.28 Protein of unknown function Y57A10A.29 Y57A10A.DD;Y57A10A.29 Protein of unknown function Y57A10A.3 Y57A10A.3 Protein of unknown function, has strong similarity to C. elegans Y57A10A.C Y57A10A.30 Y57A10A.30 Putative paralog of C. elegans ife-5 (Putative translation initiation factor eIF4E, binds to mRNA cap structure) ife-5 encodes a member of the Initiation Factor 4E (eIF4E) family; it is expressed in the germ line. Y57A10A.31 Y57A10A.FF;Y57A10A.31 Protein with moderate similarity to C. elegans Y73F8A.34 gene product Y57A10A.4 Y57A10A.4 Protein of unknown function, putative paralog of C. elegans Y57A10A.5 Y57A10A.5 Y57A10A.5 Protein of unknown function, putative paralog of C. elegans Y57A10A.4 Y57A10A.6 Y57A10A.F;Y57A10A.6 Protein of unknown function, has high similarity to uncharacterized C. elegans Y57A10A.4 Y57A10A.7 Y57A10A.G;Y57A10A.7 Protein of unknown function, has moderate similarity to uncharacterized C. elegans T28A8.4 Y57A10A.8 Y57A10A.H;Y57A10A.8 Protein of unknown function, has moderate similarity to uncharacterized C. elegans T28A8.4 Y57A10A.9 Y57A10A.9 Protein of unknown function, putative paralog of C. elegans Y57A10A.Y Y57A10A.EE ife-5;Y57A10A.EE Putative translation initiation factor eIF4E, binds to mRNA cap structure Y57A10A.I rol-1;Y57A10A.11;Y57A10A.I Protein containing two collagen triple helix repeats and one nematode cuticle collagen N-terminal domain, has low similarity to C. elegans DPY-16, which is a collagen and is involved in morphogenesis of the epithelium Y57A10A.S rsr-2;Y57A10A.S Protein of unknown function, has strong similarity to uncharacterized C. elegans Y57A10A.19 Y57A10B.1 Y57A10B.1 Protein with weak similarity to C. elegans C17E4.3 gene product Y57A10B.2 Y57A10B.2 Protein of unknown function Y57A10B.3 Y57A10B.3 Protein containing a BTB (BR-C, ttk and babor) or POZ (Pox virus and zinc finger) domain, which are found in some DNA and actin binding proteins and may mediate protein-protein interactions, has moderate similarity to uncharacterized C. elegans F57C2.1 Y57A10B.4 Y57A10B.4 Member of the C. elegans Sre G protein-coupled chemoreceptor family, which are putative chemosensory receptors, has high similarity to uncharacterized C. elegans Y57A10B.5 7TM receptor, sre family Y57A10B.5 Y57A10B.5 Member of the C. elegans Sre G protein-coupled chemoreceptor family, which are putative chemosensory receptors, has high similarity to uncharacterized C. elegans Y57A10B.4 7TM receptor, sre family Y57A10B.6 Y57A10B.6 Protein of unknown function, has low similarity to uncharacterized C. elegans Y46G5A.28 Y57A10B.7 Y57A10B.7 Protein of unknown function Y57A10C.1 Y57A10C.1 Protein of unknown function, has high similarity to uncharacterized C. elegans F57G9.3 Y57A10C.10 Y57A10C.10 Protein containing two DUF40 domains of unknown function, which contain four conserved cysteines, has low similarity to uncharacterized C. elegans Y57A10C.8 Y57A10C.3 Y57A10C.3 Member of the C. elegans Sre G protein-coupled chemoreceptor family, which are putative chemosensory receptors, has moderate similarity to uncharacterized C. elegans T07C12.6 7TM receptor, sre family Y57A10C.4 Y57A10C.4 Member of the C. elegans Sre G protein-coupled chemoreceptor family, which are putative chemosensory receptors, has high similarity to uncharacterized C. elegans Y57A10C.5 7TM receptor, sre family Y57A10C.5 Y57A10C.5 Member of the C. elegans Sre G protein-coupled chemoreceptor family, which are putative chemosensory receptors, has high similarity to uncharacterized C. elegans Y57A10C.4 Y57A10C.6 P-44;Y57A10C.6 3-keto-acyl-CoA thiolase 3-keto-acyl-CoA thiolase Y57A10C.7 Y57A10C.7 Protein of unknown function, has high similarity to uncharacterized C. elegans Y57A10C.8 7 transmembrane receptor (rhodopsin family) Y57A10C.8 Y57A10C.8 Member of the rhodopsin family of G-protein coupled receptors (GPCR), has high similarity to uncharacterized C. elegans Y57A10C.7 7 transmembrane receptor (rhodopsin family) Y57A10C.9 Y57A10C.9 Protein of unknown function, has high similarity to uncharacterized C. elegans Y57A10C.7 Y57E12AL.2 Y57E12AL.2 Putative ortholog of C. elegans Y57E12AL.E gene product Y57E12AL.4 Y57E12AL.4 Protein of unknown function Y57E12AL.6 Y57E12AL.6 Putative ortholog of C. elegans Y57E12AL.A gene product Y57E12AM.1 Y57E12AM.1 Protein with strong similarity to C. elegans Y57E12AM.A gene product Y57E12B.A Y57E12B.4;Y57E12B.A Protein with strong similarity to C. elegans Y57E12B.1 gene product Y57E12B.B Y57E12B.3;Y57E12B.B Putative ortholog of H. sapiens LIPF (lipase, gastric) Y57E12B.C Y57E12B.2;Y57E12B.C Protein of unknown function Y57E12B.D Y57E12B.1;Y57E12B.D Protein with strong similarity to C. elegans Y57E12B.4 gene product Y57E12_247.D mdt-6;CeMed6;c-MED6;Y57E12AL.5;Y57E12_247.D Protein of unknown function, has a region of moderate similarity to RNA polymerase II transcriptional regulation mediator (human MED6), which hyperphosphorylates the C-terminal domain of RNA polymerase II and regulates transcription Y57G11A.1 Y57G11A.1 Protein containing a LIM domain, which may mediate protein-protein interactions LIM domain containing proteins Y57G11A.2 Y57G11A.2 Protein with strong similarity to C. elegans Y9C9A.1 gene product Y57G11A.3 Y57G11A.3 Protein containing a LIM domain, which may mediate protein-protein interaction, has weak similarity to a region of epithelial protein lost in neoplasm beta (human EPLIN), which is a component of the actin cytoskeleton that regulates cell growth LIM domain containing proteins Y57G11A.4 Y57G11A.4 Protein of unknown function Y57G11A.5 Y57G11A.5 Protein containing an RNA recognition motif (RRM, RBD, or RNP), has a region of moderate similarity to a region of splicing factor arginine serine rich 7 (human SFRS7), which is a splicing factor of the SR protein family RNA recognition motif. (aka RRM, RBD, or RNP domain) Y57G11B.1 Y57G11B.1 Protein of unknown function, has high similarity to uncharacterized C. elegans T27E7.6 Y57G11B.2 Y57G11B.2 Protein of unknown function, has weak similarity to C. elegans Y4C6B.C Y57G11B.3 Y57G11B.3 Protein with moderate similarity to C. elegans F21A3.6 gene product Ubiquitin carboxyl-terminal hydrolases family 2 Y57G11B.5 Y57G11B.5 Protein of unknown function, has low similarity to uncharacterized C. elegans C40C9.3 Y57G11C.1 Y57G11C.1 Member of the ABC transporter family, contains an ABC transporter transmembrane domain, has moderate similarity to a region of P-glycoprotein (ATP-binding cassette subfamily B member 1, human ABCB1), which is a multidrug efflux pump ABC transporter; The haf-8 gene encodes a homolog of human CHM, which when mutated leads to choroideraemia (OMIM:303100). Y57G11C.10 gdi-1;Y57G11C.10 Putative GDP dissociation inhibitor GDI-1 GDP dissociation inhibitor; gdi-1 encodes a member of the Rab GDP dissociation inhibitor (GDI) family with high similarity to Drosophila Gdi; expressed around the pharyngeal, vulval, and tail regions. Y57G11C.11 coq-3;Y57G11C.11 Methyltransferase required for ubiquinone synthesis; similar to S. cerevisiae Coq3p dihydroxypolyprenylbenzoate methyltransferase; coq-3 encodes a putative 3,4-dihydroxy-5-hexaprenylbenzoate methyltransferase, orthologous to S. cerevisiae COQ3; COQ-3 is required for ubiquinone biosynthesis and for normally short lifespan; coq-3(RNAi) animals have reduced levels of coenzyme Q8, coenzyme Q9, and superoxide, and have abnormally long lifespans. Y57G11C.12 Y57G11C.12 Protein with strong similarity to human NADH-ubiquinone oxidoreductase subunit CI-B14 (NDUFA6) NADH-ubiquinone oxidoreductase Y57G11C.13 Y57G11C.13 Member of the ADP-ribosylation factor (ARF) family, has low similarity to human ARF1, which is a GTP-binding protein that regulates the binding of coat protein complex proteins to endosomes ADP-ribosylation factor Y57G11C.14 Y57G11C.14 Protein of unknown function, has strong similarity to uncharacterized C. elegans ZK637.12 Y57G11C.15 Y57G11C.15 Protein with high similarity to S. cerevisiae Sec61p, which is a component of the Sec61p-Sss1p-Sbh1p complex and is involved in protein translocation into the endoplasmic reticulum, member of the SecY protein family, which are protein translocators protein transport protein SEC61 alpha subunit Y57G11C.16 Y57G11C.16 Protein with high similarity to ribosomal protein S18 (S. cerevisiae Rps18ap), which is a ribosomal structural protein, member of the ribosomal S13 or S18 family, which are part of the small ribosomal subunit ribosomal protein S13; rps-18 encodes a small ribosomal subunit S18 protein. Y57G11C.17 Y57G11C.17 Protein of unknown function, has low similarity to uncharacterized human FLJ10724 Y57G11C.18 Y57G11C.18 Protein of unknown function, has very strong similarity to uncharacterized C. elegans F54H12.4 Y57G11C.19 Y57G11C.19 Protein containing a retroviral integrase core domain, which are the central catalytic domains that can act as endonucleases, has moderate similarity to uncharacterized C. elegans Y40C7B.2 chromatin organization modifier domain Y57G11C.2 Y57G11C.2 Protein containing three neurotransmitter-gated ion-channel ligand binding domains, has a region of low similarity to a region of C. elegans ACR-4, which is an acetylcholine-gated channel subunit neurotransmitter-gated ion-channel Y57G11C.20 Y57G11C.20 Putative ortholog of C. elegans K09F6.6 gene product Y57G11C.21 Y57G11C.21 Putative ortholog of C. elegans K09F6.5 gene product Y57G11C.22 pick1-like;Y57G11C.22 PKC alpha-binding protein perinuclear binding protein Y57G11C.23 Y57G11C.23 Member of the sugar (and other) transporter family, has weak similarity to solute carrier family 22 (organic cation transporter) member 2 (human SLC22A2), which is a organic cation transporter transport protein Y57G11C.24 Y57G11C.24 Protein containing a Src homology 3 (SH3) domain, which bind proline-rich peptides, has low similarity to epidermal growth factor (EGF) receptor pathway substrate 8 (mouse Eps8), which enhances EGF-induced mitogenesis and mediates mouse Rac1 activation epidermal growth factor receptor kinase substrate; eps-8 is predicted to encode five protein isoforms with similarity to mouse epidermal growth factor receptor kinase substrate that affects embryonic viability, growth, locomotion, osmoregulation, and larval viability; interacts with GEX-3 in yeast two-hybrid assays. Y57G11C.25 Y57G11C.25 Protein containing two CCCH-type zinc finger domains, which bind DNA or RNA, has a region of high similarity to a region of C. elegans POS-1, which is a zinc-finger protein involved in regulation of early morphogenesis Zinc finger C-x8-C-x5-C-x3-H type (and similar). (2 domains) Y57G11C.27 Y57G11C.27 Protein of unknown function, has high similarity to uncharacterized C. elegans M162.4 Y57G11C.3 Y57G11C.3 Member of the glucosamine-6-phosphate isomerase family, which catalyze conversion of glucosamine 6-phosphate into fructose-6-phosphate, has low similarity to S. pombe Pglp, which is a 6-phosphoglucolactonase SOL/DEVB family Y57G11C.31 Y57G11C.31 Protein of unknown function, has high similarity to uncharacterized C. elegans Y48E1B.8 Y57G11C.32 Y57G11C.32 Protein of unknown function Y57G11C.33 Y57G11C.33 Protein with weak similarity to D. melanogaster CG5447 (CG5447 gene product) Y57G11C.34 Y57G11C.34 Protein of unknown function mitochondrial ribosomal protein S7 Y57G11C.4 Y57G11C.4 Possible mitochondrial small subunit protein Y57G11C.5 Y57G11C.5 Putative ortholog of C. elegans Y73F8A.20 gene product Y57G11C.6 Y57G11C.6 Member of the protein-tyrosine phosphatase family, which are involved in control of cell growth, proliferation, differentiation and transformation, has high similarity to uncharacterized C. elegans C24D10.1, which is involved in control of cell growth protein-tyrosine phosphatase Y57G11C.7 Y57G11C.7 Protein containing two DUF38 domains of unknown function, and an F-box domain, which serve as a link between a target protein and a ubiquitin-conjugating enzyme, has a region of moderate similarity to a region of C. elegans FOG-2 Y57G11C.8 Y57G11C.8 Protein with moderate similarity to C. elegans Y39E4B.C gene product Y57G11C.9 Y57G11C.9 Protein containing two RNA recognition motifs (RRM, RBD, or RNP) RNA recognition motif Y57G7A.1 Y57G7A.1 Protein of unknown function Y57G7A.10 Y57G7A.10 Protein containing three TPR (tetratrico peptide repeat) domains, which may mediate protein-protein interactions, has moderate similarity to uncharacterized human KIAA0103 Y57G7A.11 Y57G7A.11 Protein of unknown function Y57G7A.2 Y57G7A.2 Protein of unknown function Y57G7A.3 Y57G7A.3 Protein of unknown function, has high similarity to uncharacterized C. elegans C06C6.8 Y57G7A.4 Y57G7A.4 Protein of unknown function, has high similarity to uncharacterized C. elegans F18E3.5 7TM chemoreceptor, srw family Y57G7A.5 Y57G7A.5 Protein of unknown function Y57G7A.6 Y57G7A.6 Protein containing a WSN domain of unknown function, has high similarity to uncharacterized C. elegans F36G9.13 Y57G7A.7 Y57G7A.7 Protein containing a DUF216 domain of unknown function, has moderate similarity to uncharacterized C. elegans F40D4.9 7TM chemoreceptor, srz family Y57G7A.8 Y57G7A.8 Protein of unknown function, has weak similarity to C. elegans Y71A12B.D Y57G7A.9 Y57G7A.9 Protein of unknown function, has weak similarity to C. elegans C29F5.7 Y58A7A.1 Y58A7A.1 Putative ortholog of C. elegans Y58A7A.E gene product Y58A7A.2 Y58A7A.2 Protein with strong similarity to C. elegans Y58A7A.D gene product Y58A7A.3 Y58A7A.3 Putative ortholog of C. elegans Y58A7A.B gene product Y58A7A.4 Y58A7A.4 Putative ortholog of C. elegans Y58A7A.B gene product Y58A7A.5 Y58A7A.5 Putative ortholog of C. elegans Y58A7A.B gene product Y58A7A.6 Y58A7A.6 Putative ortholog of C. elegans Y58A7A.A gene product Y58G8A.1 Y58G8A.1 Putative paralog of C. elegans Y58G8A_208.B ion channel protein Y58G8A.2 Y58G8A.2 Putative paralog of C. elegans F09C3.6 Y58G8A.3 Y58G8A.3 Putative paralog of C. elegans Y58G8A_208.A Y58G8A.4 Y58G8A.4 Protein of unknown function, has strong similarity to C. elegans Y58G8A_208.A Y59A8A.1 Y59A8A.1 Protein of unknown function csn-1 encodes an ortholog of subunit 1 of the COP9 signalosome complex (CSN1), which in turn is a pan-eukaryotic multiprotein complex that positively regulates E3 ubiquitin ligases, physically interacts with SCF-type E3 ubiquitin ligases, and probably regulates protein degradation; in mass RNAi assays, csn-1 is required for embryonic viability, maintenance of the germline, and general health. Y59A8A.2 Y59A8A.2 Protein with moderate similarity to C. elegans lin-49 gene product Y59A8A.3 Y59A8A.3 Protein of unknown function Y59A8A.4 Y59A8A.4 Putative ortholog of C. elegans Y59A8A.7 gene product G-protein coupled receptor, srh family Y59A8A.5 Y59A8A.5 Putative ortholog of C. elegans Y94A7B.9 gene product Y59A8A.7 Y59A8A.7 Putative ortholog of C. elegans Y59A8A.4 gene product Y59A8B.1 Y59A8B.1 Putative ortholog of C. elegans Y59A8A.A gene product Y59A8B.10 Y59A8B.10 Putative ortholog of C. elegans Y59A8A.G gene product Y59A8B.11 Y59A8B.11 Putative ortholog of C. elegans Y59A8A.F gene product Y59A8B.12 Y59A8B.12 Putative ortholog of C. elegans Y59A8A.E gene product Y59A8B.13 Y59A8B.13 Putative ortholog of C. elegans Y59A8B.W gene product Y59A8B.14 Y59A8B.14 Putative ortholog of C. elegans par-4 gene product serine-threonine protein kinase; par-4 is orthologous to the human gene UNKNOWN (PROTEIN FOR MGC:12715) (STK11; OMIM:602216), which when mutated leads to disease. Y59A8B.19 Y59A8B.19 Protein with moderate similarity to C. elegans Y59A8A.Q gene product Y59A8B.2 Y59A8B.2 Protein with strong similarity to C. elegans Y59A8B.B gene product Y59A8B.20 Y59A8B.20 Putative ortholog of C. elegans Y59A8A.R gene product Y59A8B.21 Y59A8B.21 Putative ortholog of C. elegans Y59A8A.S gene product Y59A8B.22 Y59A8B.22 Putative ortholog of C. elegans Y59A8B.G gene product Y59A8B.23 Y59A8B.23 Putative ortholog of C. elegans Y59A8A.B gene product Y59A8B.24 Y59A8B.24 Putative ortholog of C. elegans Y59A8B.D gene product Y59A8B.3 Y59A8B.3 Putative ortholog of C. elegans Y59A8A.N gene product G-protein coupled receptor, srh family Y59A8B.4 Y59A8B.4 Putative ortholog of C. elegans T27C5.5 gene product G-protein coupled receptor, srh family Y59A8B.5 Y59A8B.5 Putative ortholog of C. elegans T27C5.5 gene product Y59A8B.6 Y59A8B.6 Putative ortholog of C. elegans Y59A8A.M gene product Y59A8B.7 Y59A8B.7 Protein with strong similarity to C. elegans Y59A8B.P gene product Y59A8B.8 Y59A8B.8 Putative ortholog of C. elegans Y59A8B.S gene product gamma-soluble NSF attachment protein (SNAP-gamma) Y59A8B.9 Y59A8B.9 Protein with strong similarity to C. elegans Y59A8B.7 gene product Y59C2A.1 Y59C2A.1 Member of the carboxypeptidase A metalloprotease (M14) family of zinc carboxypeptidases, has low similarity to carboxypeptidase A4 (human CPA4), which may affect production of peptide hormones involved in growth of prostate epithelial cells carboxypeptidase Y59C2A.2 Y59C2A.2 Protein of unknown function, has similarity to human HS.199259 (cosmid R32184 on chromosome 19) Y59C2A.3 Y59C2A.3 Protein with moderate similarity to C. elegans Y50D7A.A gene product Y59E1A.2 rgs-8;F52D2.2;Y59E1A.2 Protein containing two regulator of G protein signaling domains, has a region of low similarity to regulator of G protein signaling 1 (mouse Rgs1), which regulates G protein-coupled receptor signaling Y59E1A.A Y59E1A.3;F52D2.3;Y59E1A.A Protein of unknown function, has high similarity to uncharacterized C. elegans Y39A3A.1 Y59E1B.1 Y59E1B.1 Protein of unknown function, putative paralog of C. elegans Y59E1B_62.B Y59E1B.2 Y59E1B.2 Protein of unknown function Y59E9AL.1 Y59E9AL.1 Protein of unknown function, has strong similarity to C. elegans F28D1.3 Y59E9AL.4 Y59E9AL.4 Putative paralog of C. elegans T07G12.5 Y59E9AL.5 Y59E9AL.5 Protein of unknown function, has weak similarity to C. elegans C06A1.6 Y59E9AL.6 Y59E9AL.6 Putative paralog of C. elegans C41G7.6 Y59E9AR.1 Y59E9AR.1 Protein with strong similarity to C. elegans msp-51 Y59E9AR.2 Y59E9AR.2 Protein of unknown function, putative paralog of C. elegans Y59E9AR.8 Y59E9AR.3 Y59E9AR.3 Putative paralog of C. elegans Y59E9AR.5 Y59E9AR.4 Y59E9AR.4 Protein of unknown function, putative paralog of C. elegans Y59E9AR.6 Y59E9AR.5 Y59E9AR.5 Putative paralog of C. elegans Y59E9AR.3 Y59E9AR.6 Y59E9AR.6 Protein of unknown function, putative paralog of C. elegans Y59E9AR.4 Y59E9AR.7 Y59E9AR.7 Protein with strong similarity to C. elegans msp-51 Y59E9AR.8 Y59E9AR.8 Protein of unknown function, putative paralog of C. elegans Y59E9AR.2 Y59E9_118.A Y59E9AL.3;Y59E9AL.2;Y59E9_118.A Protein of unknown function, has very strong similarity to uncharacterized C. elegans ZK546.7 Y59H11AL.A Y59H11AL.1;Y59H11AL.A Protein with strong similarity to C. elegans AC7.1 gene product Y59H11AM.A Y59H11AM.4;Y59H11AM.A Protein with weak similarity to C. elegans C52B9.8 (Putative helicase, strongly related to chromatin remodeling and transcription activation proteins of the SNF2/RAD54 family) Y59H11AM.B Y59H11AM.2;Y59H11AM.B Member of the Rhodanese-like domain family Y59H11AM.C Y59H11AM.3;Y59H11AM.C Member of the Rhodanese-like domain family Y59H11AM.D Y59H11AM.1;Y59H11AM.D Protein with strong similarity to C. elegans msp-31 (Member of the major sperm protein family) Y59H11AR.4 Y59H11AR.A;Y59H11AR.4 Putative ortholog of C. elegans Y18D10A.M gene product Y59H11AR.B Y59H11AR.3;Y59H11AR.B Protein with moderate similarity to C. elegans T26A8.3 gene product Y59H11AR.C Y59H11AR.2;Y59H11AR.c Putative ortholog of C. elegans K07E3.6 gene product Y59H11AR.D Y59H11AR.1;Y59H11AR.D Protein of unknown function Y5F2A.1 Y5F2A.1 Member of the transthyretin-like family, has high similarity to uncharacterized C. elegans Y5F2A.2 Transthyretin-like family Y5F2A.2 Y5F2A.2 Member of the transthyretin-like family, has high similarity to uncharacterized C. elegans Y5F2A.1 Transthyretin-like family Y5F2A.3 Y5F2A.3 Protein with similarity over the C-terminal half to tyrosine protein phosphatases of human and D. melanogaster Y5F2A.4 Y5F2A.4 Protein containing seven C2H2 type zinc finger domains, which bind nucleic acids, has a region of low similarity to a region of zinc finger protein X-linked (mouse Zfx), which is a transcription factor important for germ cell and embryonic development Zinc finger, C2H2 type (7 domains) Y5H2A.B Y5H2A.1;Y5H2A.B Putative ortholog of C. elegans F41E6.8 gene product Y5H2A.C Y5H2A.2;Y5H2A.C Protein of unknown function, with weak similarity to human acetyl LDL receptor SREC Y5H2B.1 Y5H2B.1 Putative ortholog of C. elegans F31F4.17 gene product Y5H2B.2 nhr-13;Y5H2B.2 Member of Nuclear Hormone Receptor superfamily nhr-13 encodes a member of the nuclear hormone receptor family. Y5H2B.3 Y5H2B.3 Protein with strong similarity to C. elegans Y5H2B.G gene product Y5H2B.4 Y5H2B.4 Putative ortholog of C. elegans Y5H2B.E gene product Y5H2B.5 Y5H2B.5 Putative ortholog of C. elegans Y5H2B.C gene product Y5H2B.6 Y5H2B.6 Putative ortholog of C. elegans C50H11.15 gene product Y5H2B.7 Y5H2B.7 Putative ortholog of C. elegans Y5H2B.A gene product 7TM chemoreceptor, srt family Y60A3.W unc-51;Y60A3.Y;Y60A3.W Serine/threonine protein kinase involved in axon morphogenesis and elongation Y60A3A.1 Y60A3A.1 Putative paralog of C. elegans unc-51 (Serine/threonine protein kinase involved in axon morphogenesis and elongation) serine/threonine protein kinase; The unc-51 gene encodes an activity required for both axonogenesis and sex myoblast migration. Y60A3A.10 Y60A3A.10 Putative paralog of C. elegans Y60A3.K dhs-24 encodes a member of the short-chain dehydrogenases/reductases family (SDR). Y60A3A.12 cds-1;chk-2;Ce-cds-1;Ce-chk-2;Y60A3A.12 Required for pairing of homologous chromosomes during meiosis chk-2 encodes a member of the Cds1/Chk2 checkpoint kinase family, orthologous to human CHK2 (OMIM:604373, mutated in Li-Fraumeni syndrome), that affects pairing between homologous chromosomes during early meiotic prophase, and might function to couple premeiotic S phase with early prophase; CHK-2 is expressed in the germ line. Y60A3A.13 Y60A3A.13 Protein with strong similarity to H. sapiens FARS1 (phenylalanine-tRNA synthetase) Y60A3A.14 Y60A3A.14 Putative ortholog of H. sapiens DPAGT1 (dolichyl-phosphate (UDP-N-acetylglucosamine) N-acetylglucosaminephosphotransferase 1 (GlcNAc-1-P transferase)) Y60A3A.15 Y60A3A.15 Protein of unknown function, putative paralog of C. elegans Y60A3.G Y60A3A.16 Y60A3A.16 Protein with strong similarity to C. elegans Y60A3.D Y60A3A.18 Y60A3.F;Y60A3A.18 Member of the Skp1 family, which are required for targeted protein degradation during the cell cycle, has moderate similarity to a region of S. cerevisiae Skp1p, which is a component (subunit d) of the Cbf3 kinetochore complex The skr-4 gene encodes a homolog of Skp1 in S. cerevisiae that has no known function in vivo, since skr-4(RNAi) animals are at least superficially normal. Y60A3A.19 Y60A3A.19 Protein of unknown function, has moderate similarity to C. elegans Y60A3.C Y60A3A.2 Y60A3A.2 Protein of unknown function, putative paralog of C. elegans Y60A3.T Y60A3A.3 Y60A3A.3 Protein of unknown function, putative paralog of C. elegans Y60A3.R Y60A3A.4 Y60A3A.4 Protein of unknown function, putative paralog of C. elegans Y60A3.Q Y60A3A.5 Y60A3A.5 Protein of unknown function, putative paralog of C. elegans Y60A3A.6 Y60A3A.6 Y60A3A.6 Protein of unknown function, putative paralog of C. elegans Y60A3A.5 Y60A3A.7 Y60A3A.7 Putative paralog of C. elegans C44C1.5 Y60A3A.8 Y60A3A.8 Protein of unknown function, putative paralog of C. elegans Y60A3.M Y60A3A.9 Y60A3A.9 Protein with strong similarity to C. elegans Y60A3.L Y60A9.1 Y60A9.1 Protein of unknown function, putative paralog of C. elegans Y60A9.B Y60A9.2 Y60A9.2 Protein with strong similarity to C. elegans F38C2.5 Y60A9.3 Y60A9.A;Y60A9B.A;Y60A9.3 Protein containing two CCCH-type zinc finger domains, which bind DNA or RNA, has a region of high similarity to C. elegans POS-1, which is involved in regulation of early morphogenesis Y60C6A.1 Y60C6A.A;Y60C6A.1 Protein containing a CX module domain Y61A9LA.1 Y61A9LA.1 Protein with moderate similarity to D. melanogaster Glut1 (Glucose transporter 1) Y61A9LA.10 Y61A9LA.10 Putative ortholog of C. elegans Y61A9LA.A gene product Y61A9LA.11 Y61A9LA.11 Putative ortholog of C. elegans Y61A9LA.B gene product Y61A9LA.4 Y61A9LA.4 Protein of unknown function, putative paralog of C. elegans F49C5.3 Y61A9LA.5 Y61A9LA.5 Putative ortholog of C. elegans Y61A9LA.H gene product Y61A9LA.6 sos-1;let-341;Y61A9LA.6 Ortholog of Son of sevenless, a guanine nucleotide exchange factor in the Ras developmental signaling pathway, believed to stimulate the Ras GTPase LET-60 Y61A9LA.7 Y61A9LA.7 Protein of unknown function Y61A9LA.8 Y61A9LA.8 Protein of Unknown function Y61A9LA.9 Y61A9LA.9 Protein of unknown function, has moderate similarity to C. elegans H02F09.4 Y61B8A.1 Y61B8A.1 Member of the 7-transmembrane chemoreceptor family of G-protein coupled receptors (GPCR), has weak similarity to uncharacterized C. elegans K08G2.8 G-protein coupled receptor, srh family Y61B8A.2 Y61B8A.2 Member of the 7-transmembrane chemoreceptor family of G-protein coupled receptors (GPCR), has high similarity to uncharacterized C. elegans K10G4.6 G-protein coupled receptor, srh family Y61B8B.1 Y61B8B.1 Member of the 7-transmembrane chemoreceptor family of G-protein coupled receptors (GPCR), has strong similarity to uncharacterized C. elegans Y102A5C.32 7TM chemoreceptor, sri family Y61B8B.2 Y61B8B.2 Protein with strong similarity to C. elegans Y40B10B.B gene product Y62E10A.10 Y62E10.C;Y62E10A.H;Y62E10A.10 Protein of unknown function, has high similarity to uncharacterized human LOC55831 Y62E10A.12 Y62E10A.12 Protein with weak similarity to S. cerevisiae LSM3 (U6 snRNA-associated protein of the Sm-like group) Y62E10A.13 Y62E10A.13 Protein of unknown function Y62E10A.15 Y62E10A.15 Putative paralog of C. elegans Y17G9B.3 Y62E10A.16 Y62E10A.16 Putative paralog of C. elegans Y62E10.E Y62E10A.17 Y62E10A.17 Putative paralog of C. elegans Y62E10.F Y62E10A.4 Y62E10A.4 Protein with strong similarity to C. elegans C03G6.16 Y62E10A.6 Y62E10A.6 Protein with strong similarity to S. cerevisiae ARH1 (Mitochondrial protein with similarity to human NAPDH-adrenodoxin reductase) Y62E10A.9 Y62E10A.9 Protein with strong similarity to S. cerevisiae YPT1 (GTP-binding protein required for vesicle transport from ER to Golgi and within the Golgi stack, member of the rab family in the ras superfamily) rab-19 encodes a small GTPase homologous to the Rab GTPases that function in endocytosis, membrane fusion, and vesicular trafficking events; the precise biological role and expression pattern of rab-19 are not yet known. Y62F5A.1 Y62F5A.1 Protein of unknown function Y62H9A.1 Y62H9A.1 Protein of unknown function Y62H9A.10 Y62H9A.10 G protein-coupled receptor of an unnamed subfamily, has weak similarity to human somatostatin receptor Y62H9A.11 Y62H9A.11 Protein of unknown function Y62H9A.12 Y62H9A.12 Protein of unknown function Y62H9A.13 Y62H9A.13 Protein of unknown function Y62H9A.14 Y62H9A.14 Protein of unknown function Y62H9A.2 Y62H9A.2 Protein of unknown function Y62H9A.3 Y62H9A.3 Protein of unknown function, has weak similarity to C. elegans Y62H9A.5 Y62H9A.4 Y62H9A.4 Protein with moderate similarity to C. elegans Y62H9A.6 gene product Y62H9A.5 Y62H9A.5 Protein of unknown function, has weak similarity to C. elegans Y62H9A.3 Y62H9A.6 Y62H9A.6 Protein with moderate similarity to C. elegans Y62H9A.4 gene product Y62H9A.7 Y62H9A.7 Protein of unknown function Y62H9A.8 Y62H9A.8 Protein of unknown function Y62H9A.9 Y62H9A.9 Protein of unknown function Y63D3A.10 Y63D3A.1;Y63D3A.10 Protein containing two F-box domains, which serve as a link between a target protein and a ubiquitin-conjugating enzyme This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins. Y63D3A.11 Y63D3A.11 Protein of unknown function, putative paralog of C. elegans Y63D3A.9 Y63D3A.2 Y63D3A.2 Protein containing an F-box domain, which serve as a link between a target protein and a ubiquitin-conjugating enzyme, has low similarity to uncharacterized C. elegans T17A3.4 This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins. Y63D3A.3 Y63D3A.3 Protein of unknown function, has low similarity to uncharacterized C. elegans Y8A9A.5 Y63D3A.4 Y63D3A.4 Member of the apurinic or apyrimidinic (AP) endonuclease family 1, which cleave DNA at AP sites, has low similarity to TRAF and TNF receptor-associated protein (mouse Ttrap), which binds and inhibits several proteins and may regulate nuclear transcription Y63D3A.5 Y63D3A.5 Protein containing a octicosapeptide repeat domain, which may bind divalent cations Y63D3A.6 Y63D3A.6 Protein containing two DnaJ domains and two Sec63 domains, has a region of low similarity to a region of S. cerevisiae Sec63p, which is a component of an ER protein-translocation subcomplex including Sec62p, Sec63p, Sec66p, and Sec72p DnaJ domain; This gene encodes a protein containing a DnaJ ('J') domain. Y63D3A.7 Y63D3A.7 Protein with high similarity to NADH dehydrogenase (ubiquinone) 1 alpha subcomplex 2 (8kD) (human NDUFA2), which is a subunit of the NADH-ubiquinone oxidoreductase multiprotein complex that transports electrons during oxidative phosphorylation Y63D3A.8 Y63D3A.8 Protein of unknown function, has high similarity to uncharacterized C. elegans K12H6.6 Y63D3A.9 Y63D3A.9 Protein containing an F-box domain, which serve as a link between a target protein and a ubiquitin-conjugating enzyme, has high similarity to uncharacterized C. elegans Y63D3A.11 This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins. Y64G10A.1 Y64G10A.1 Putative paralog of C. elegans F02H6.6 Y64G10A.3 Y64G10.C;Y64G10A.C;Y64G10A.3 Putative ortholog of C. elegans Y56A3A.9 gene product Y64G10A.5 Y64G10A.5 Putative paralog of C. elegans F27B3.4 Y64G10A.6 Y64G10.E;Y64G10A.E;Y64G10A.6 Protein of unknown function Y64G10A.7 Y64G10A.7 Putative ortholog of D. melanogaster N (Notch) The Y64G10A.7 gene encodes a homolog of the human gene FIBRILLIN-1, which when mutated leads to Marfan syndrome (OMIM:154700). Y64H9A.1 Y64H9A.1 Protein with strong similarity to C. elegans T09E8.3 gene product Y64H9A.2 Y64H9A.2 Protein of unknown function Y65A5A.1 Y65A5A.A;Y65A5A.1 Protein of unknown function Y65A5A.2 Y65A5A.2 Protein of unknown function Y65A5A.3 Y65A5A.3 Protein of unknown function Y65B4A.1 Y65B4A.1 Putative ortholog of C. elegans Y65B4A_179.B gene product Y65B4A.2 Y65B4A.2 Putative ortholog of C. elegans Y65B4A.I gene product Y65B4A.4 Y65B4A.4 Protein with strong similarity to C. elegans C18E3.6 gene product Y65B4A.5 Y65B4A.5 Putative ortholog of C. elegans Y65B4A.F gene product Y65B4A.A Y65B4A.9;Y65B4A.A Putative paralog of C. elegans ZK354.2 Y65B4A.B Y65B4A.8;Y65B4A.B Protein with moderate similarity to S. cerevisiae YGR277C Y65B4A.C Y65B4A.7;Y65B4A.C Protein with weak similarity to C. elegans unc-97 (Member of the PINCH family of LIM-only proteins) Y65B4A.E Y65B4A.6;Y65B4A.E Putative ortholog of S. cerevisiae FAL1 gene product (Putative ATP-dependent RNA helicase with similarity to eukaryotic initiation factor 4A subfamily of DEAD-box proteins) Y65B4A.G F56A6.1;Y65B4A.G Putative paralog of C. elegans C18E3.7 Y65B4A.H Y65B4A.3;Y65B4A.H Protein with weak similarity to D. melanogaster CG4071 (CG4071 gene product) Y65B4A_179.B Y65B4A_179.B Member of the papain family of cysteine proteases, has a region of low similarity to a region of HIV TAT specific factor 1 (human HTATSF1), which is a transcription elongation factor that is required for transcriptional activation by the HIV-1 Tat protein Y65B4BL.1 Y65B4BL.1 Putative ortholog of C. elegans Y65B4BM.1 gene product Y65B4BL.2 Y65B4BL.2 Protein of unknown function Y65B4BL.3 Y65B4BL.3 Protein of unknown function Y65B4BL.4 Y65B4BL.4 Protein of unknown function Y65B4BL.5 Y65B4BL.5 Putative ortholog of S. cerevisiae FAA2 gene product (Acyl-CoA synthetase (long-chain fatty acid CoA ligase, fatty acid activator 2), activates endogenous but not imported fatty acids, provides substrates for N-myristoylation) Y65B4BL.6 Y65B4BL.6 Protein of unknown function Y65B4BL.7 Y65B4BL.7 Protein of unknown function Y65B4BR.1 Y65B4BR.1 Putative paralog of C. elegans W02B12.1 phospholipase Y65B4BR.2 Y65B4BR.2 Protein of unknown function, has weak similarity to C. elegans W04G3.8 Y65B4BR.3 ptr-21;Y65B4BR.3 Putative paralog of C. elegans C53C11.3 ptr-21 encodes a member of the Patched superfamily. Y65B4BR.4 CeWwp1;Y65B4BR.4 Protein with similarity to the HECT (homologous to E6AP carboxy terminus) domain ubiquitin ligases that also contain a WW domain Y65B4BR.5 Y65B4BR.5 Protein with moderate similarity to D. melanogaster Nacalpha (Nascent polypeptide associated complex protein alpha subunit) Y65B4BR.6 Y65B4BR.6 Protein with moderate similarity to C. elegans cut-2 (Cuticulin component) Y65B4BR.8 Y65B4BR.8 Protein of unknown function Y66A7A.1 Y66A7A.1 Protein containing a DUF38 domain of unknown function, has low similarity to uncharacterized C. elegans C06H5.1 Y66A7A.2 Y66A7A.2 Protein of unknown function Y66A7A.3 Y66A7A.3 Protein of unknown function Y66A7A.4 Y66A7A.4 Protein with strong similarity to C. elegans R01H2.4 gene product Y66A7A.5 Y66A7A.5 Protein of unknown function Y66A7A.6 gly-8;Y66A7A.6 N-acetylgalactosaminyltransferase Glycosyl transferases; gly-8 encodes a predicted transmembrane polypeptide N-acetylgalactosaminyl transferase (ppGaNTase) similar to the essential Drosophila ppGaNTase encoded by Pgant35A; by homology, GLY-8 is predicted to function as a Golgi enzyme that catalyzes transfer of N-acetylgalactosamine to serine and threonine-containing acceptor peptides, thus initiating mucin-type O-glycosylation; as loss of gly-8 activity via large-scale RNAi screens does not result in any obvious abnormalities, the precise role of GLY-8 in C. elegans development and/or behavior is not yet known. Y66A7A.7 Y66A7A.7 Protein of unknown function Y66D12A.10 Y66D12A.10 Putative ortholog of C. elegans Y66D12A.P gene product Y66D12A.11 Y66D12A.11 Putative ortholog of C. elegans Y66D12A.O gene product Y66D12A.12 Y66D12A.12 Putative ortholog of C. elegans Y66D12A.N gene product Y66D12A.14 Y66D12A.14 Putative ortholog of C. elegans Y66D12A.L gene product Y66D12A.15 Y66D12A.15 Putative ortholog of C. elegans Y66D12A.L gene product Y66D12A.15 is orthologous to the human gene EXCISION REPAIR CROSS-COMPLEMENTING RODENT REPAIR DEFICIENCY, COMPLEMENTATION GROUP 3 (XERODERMA PIGMENTOSUM GROUP B COMPLEMENTING) (ERCC3; OMIM:133510), which when mutated leads to disease. Y66D12A.16 Y66D12A.16 Putative ortholog of C. elegans Y66D12A.K gene product Y66D12A.17 Y66D12A.17 Putative ortholog of C. elegans apc-5 gene product Y66D12A.17 encodes a paralog of GFI-3 that, like GFI-3, is distantly similar to the human anaphase promoting complex subunit APC5. Y66D12A.19 Y66D12A.19 Putative ortholog of C. elegans Y66D12A.G gene product Y66D12A.20 Y66D12A.20 Putative ortholog of C. elegans Y66D12A.F gene product spe-6 encodes a predicted protein-serine threonine kinase in the casein kinase 1 family that is required for spermatid activation, and for progression through late prophase of meiosis I, and is specifically required for the assembly of MSP (major sperm protein) in the fibrous bodies of spermatocytes; bypasses the requirement for spe-27, spe-8, spe-12, and spe-29 with respect to spermatid activation. Y66D12A.22 Y66D12A.22 Protein with strong similarity to C. elegans tim10 gene product Y66D12A.23 Y66D12A.23 Putative ortholog of C. elegans Y66D12A.B gene product Y66D12A.24 Y66D12A.24 Putative ortholog of C. elegans Y66D12A.C gene product Y66D12A.3 Y66D12A.3 Putative ortholog of C. elegans Y66D12A.W gene product Y66D12A.4 Y66D12A.4 Putative ortholog of C. elegans Y66D12A.V gene product Y66D12A.5 Y66D12A.5 Putative ortholog of C. elegans Y66D12A.V gene product Y66D12A.8 Y66D12A.8 Putative ortholog of C. elegans Y66D12A.S gene product Y66D12A.9 Y66D12A.9 Putative ortholog of C. elegans Y66D12A.Q gene product Y66D12A.E Y66D12A.21;Y66D12A.E Protein with moderate similarity to C. elegans C41D11.9 gene product Y66D12A.H Y66D12A.18;Y66D12A.H Protein of unknown function Y66D12A.M Y66D12A.13;Y66D12A.M Putative ortholog of C. elegans oat-1 gene product Y66D12A.T Y66D12A.7;Y66D12A.T Protein of unknown function Y66D12A.U Y66D12A.6;Y66D12A.U Protein of unknown function Y66D12A.Y Y66D12A.2;Y66D12A.Y Putative ortholog of C. elegans C01B12.6 gene product Y66D12A.Z Y66D12A.1;Y66D12A.Z Protein of unknown function Y66H1A.1 Y66H1A.1 Protein with strong similarity to C. elegans C49G7.9 gene product Y66H1A.3 Y66H1A.3 Possible mitochondrial large subunit protein Y66H1A.5 Y66H1A.5 Protein of unknown function Y66H1A.6 hum-8;Y66H1A.6 Protein of unknown function, contains similarity to myosin head domain Y66H1B.1 cdh-8;F18F11.3;Y66H1B.1 Protein containing five cadherin domains, which are found in the extracellular domain of some receptors and cell adhesion proteins, has low similarity to a region of cadherin 23 (otocadherin, mouse Cdh23), which is involved in sensorineural hearing Y66H1B.2 Y66H1B.2 Protein containing eight Filamin (ABP120) or Dictyostelium gelation factor (ABP280) repeat domains, which are found in actin-binding proteins, has moderate similarity to a region of filamin A (alpha, human FLNA), which is an actin crosslinking protein Y66H1B.2 is orthologous to the human gene FLJ00343 PROTEIN (FLNA; OMIM:300017), which when mutated leads to disease. Y66H1B.3 Y66H1B.3 Protein containing four Filamin (ABP120) or Dictyostelium gelation factor (ABP280 ) repeat domains, which are found in actin-binding proteins, and two calponin homology (CH) domains, has low similarity to a region of filamin C gamma (human FLNC) Y66H1B.4 spl;Y66H1B.4 Protein containing two pyridoxal-dependent group II decarboxylase conserved domains, which bind pyridoxal-phosphate groups, has moderate similarity to sphingosine phosphate lyase 1 (mouse Sgpl1), which cleaves the C2-3 carbon of sphingosine phosphate Y67A10A.1 Y67A10A.1 Putative paralog of C. elegans R03H4.5 Y67A10A.2 Y67A10A.2 Protein with strong similarity to C. elegans F02H6.7 Y67A10A.3 Y67A10A.3 Putative paralog of C. elegans C38D9.5 Y67A10A.4 Y67A10A.4 Protein of unknown function, has moderate similarity to C. elegans T09F5.11 Y67A10A.5 Y67A10A.5 Protein of unknown function, has moderate similarity to C. elegans C38D9.1 Y67A10A.6 Y67A10A.6 Protein with weak similarity to H. sapiens LOC51066 (fls485) Y67A10A.7 Y67A10A.7 Protein of unknown function Y67A10A.8 Y67A10A.8 Putative paralog of C. elegans Y32H12A.5 Y67A10A.9 Y67A10A.9 Protein of unknown function, putative paralog of C. elegans Y38F2AL.H Y67A10A.9 encodes a claudin homolog that may be required for normal cohesion of apical junctions in epithelia; Y67A10A.9 is worm-specific, with obvious homologs only in C. elegans; Y67A10A.9 has no obvious function in mass RNAi assays; claudins are integral membrane proteins with four transmembrane sequences that are found in mammalian tight junctions (TJs), induce TJs when transgenically expressed in cells normally lacking them, and can mediate the specific conductance of of specific ions (e.g., magnesium or calcium) through TJs while blocking the flow of water. Y67A6A.1 Y67A6A.1 Protein of unknown function, has strong similarity to uncharacterized C. elegans C34G6.3 Y67A6A.2 nhr-62;K10C3.1;Y67A6A.2 Member of the nuclear hormone receptor/zinc finger protein family; putative paralog of C. elegans nhr-21A nuclear hormone receptor Y67D2.1 Y67D2.1 Protein with strong similarity to C. elegans gdi-1 gene product Y67D2.2 Y67D2.2 Protein with moderate similarity to C. elegans F26G5.8 gene product Y67D2.3 Y67D2.3 Protein with weak similarity to C. elegans M88.7 gene product Y67D2.4 Y67D2.4 Protein with weak similarity to C. elegans Y67D2.2 gene product Y67D2.5 Y67D2.5 Protein of unknown function Y67D2.6 Y67D2.6 Putative ortholog of C. elegans mog-4 gene product Y67D2.7 Y67D2.7 Protein of unknown function Y67D8A.1 Y67D8A.1 Putative ortholog of C. elegans Y67D8A.F gene product Y67D8A.1 is orthologous to the human gene PHOSPHORYLASE KINASE, BETA SUBUNIT (PHKB; OMIM:172490), which when mutated leads to glycogen storage disease. Y67D8A.2 Y67D8A.2 Putative ortholog of C. elegans Y67D8A.C gene product Y67D8A.5 Y67D8A.5 Protein with strong similarity to C. elegans Y67D8A.C gene product Y67D8A.A Y67D8A.3;Y67D8A.A Protein with strong similarity to C. elegans K08B12.2 gene product Y67D8A.F Y67D8A.F Putative ortholog of C. elegans Y67D8A.1 gene product Y67D8A_380.C Y67D8C.8;Y67D8A_380.C Protein of unknown function Y67D8B.4 Y67D8B.4 Protein of unknown function Y67D8B.5 Y67D8B.5 Protein of unknown function Y67D8B.A Y67D8B.3;Y67D8B.A Protein of unknown function Y67D8B.B Y67D8B.2;Y67D8B.B Protein of unknown function, has weak similarity to C. elegans nhr-4 Y67D8B.C Y67D8B.1;Y67D8B.C Protein of unknown function, putative paralog of C. elegans ZK993.2 Y67D8C.9 Y67D8C.9 Putative ortholog of C. elegans Y67D8C.d gene product Y67D8C.B mca-3;Y67D8C.10;Y67D8A_367.A;Y67D8C.B Protein with high similarity to a plasma membrane Ca2+ ATPase type 2 pump (rat Atp2b2), which may affect vestibular hair cell function, member of the E1-E2 (P-type) ATPase and haloacid dehalogenase families, contains an ATPase N- and a C-terminus domain Y67D8C.E Y67D8C.7;Y67D8C.E Protein of unknown function Y67D8C.F Y67D8C.6;Y67D8C.F Protein with weak similarity to C. elegans Y46H3C.6 gene product Y67D8C.G Y67D8C.5;Y67D8C.G Protein with weak similarity to C. elegans Y113G7B.12 gene product Y67D8C.J Y67D8C.4;Y67D8C.J Protein of unknown function Y67D8C.K Y67D8C.3;Y67D8C.K Putative ortholog of C. elegans T23E1.2 gene product Y67D8C.M Y67D8C.2;Y67D8C.M Putative ortholog of C. elegans Y20C6A.3 gene product Y67D8C.N Y67D8C.1;Y67D8C.N Protein of unknown function Y67H2A.2 Y67H2A.2 Protein of unknown function Y67H2A.4 Y67H2A.4 Protein with strong similarity to C. elegans C56A3.6 gene product Y67H2A.5 Y67H2A.5 Protein of unknown function Y67H2A.6 Y67H2A.6 Protein with weak similarity to C. elegans rpn-8 gene product csn-6 encodes a homolog of COP9 signalosome complex subunit 2 that affects embryonic viability and fertility. Y67H2A.7 Y67H2A.7 Protein of unknown function Y67H2A.8 fat-1;fat;Y67H2B.A;Y67H2A.B;Y67H2A.8 Omega-3 fatty acid desaturase fatty acid desaturase; The fat-1 gene encodes an omega-3 fatty acyl desaturase that acts on substrates of 16-20 carbons with a preference for omega-6 fatty acids; FAT-1 dehydrogenates its substrates 3 carbons from the methyl terminus; FAT-1 is required in vivo for n3 polyunsaturated fatty acid (PUFA) synthesis. Y67H2A.A Y67H2A.1;Y67H2A.A Protein with high similarity to the 73 kDa subunit of the cleavage and polyadenylation specificity factor 3 (human CPSF3), which functions in endonucleolytic cleavage and polyadenylation of mRNA, member of the metallo-beta-lactamase family Y68A4A.1 Y68A4A.1 Member of the 7-transmembrane chemoreceptor family of G-protein coupled receptors (GPCR), has strong similarity to uncharacterized C. elegans F20E11.10 Y68A4A.10 Y68A4A.10 Protein of unknown function, has high similarity to uncharacterized C. elegans F20E11.7 Y68A4A.2 Y68A4A.2 Protein containing a DUF216 domain of unknown function, has strong similarity to uncharacterized C. elegans F20E11.1 Y68A4A.3 Y68A4A.3 Member of the 7-transmembrane chemoreceptor family of G-protein coupled receptors (GPCR), has low similarity to C. elegans ODR-10, which is involved in odorant response Y68A4A.5 Y68A4A.5 Protein of unknown function, has high similarity to uncharacterized C. elegans Y68A4A.10 Y68A4A.6 Y68A4A.6 Protein containing a DUF216 domain of unknown function, has moderate similarity to uncharacterized C. elegans Y102A5C.33 Y68A4A.7 Y68A4A.7 Member of the 7-transmembrane chemoreceptor family of G-protein coupled receptors (GPCR), has high similarity to uncharacterized C. elegans K03D7.6 Y68A4A.9 Y68A4A.9 Member of the 7-transmembrane chemoreceptor family of G-protein coupled receptors (GPCR), has strong similarity to uncharacterized C. elegans F08E10.1 Y68A4B.1 Y68A4B.1 Protein containing a C-type lectin domain, which mediate calcium-dependent carbohydrate recognition, has high similarity to uncharacterized C. elegans C31G12.2 Lectin C-type domain Y68A4B.2 Y68A4B.2 Protein containing a C-type lectin domain, which mediate calcium-dependent carbohydrate recognition, has high similarity to uncharacterized C. elegans F16H6.2 Y68A4B.3 Y68A4B.3 Protein of unknown function, has weak similarity to C. elegans Y102A5C.27 Y69A2AL.A Y69A2AL.1;Y69A2AL.A Protein with strong similarity to C. elegans Y69A2A_1798.A gene product Y69A2AR.10 Y69A2AR.10 Putative ortholog of C. elegans C17H11.3 gene product Y69A2AR.11 Y69A2AR.11 Putative ortholog of C. elegans Y69A2A_7278.A gene product Y69A2AR.16 Y69A2AR.16 Putative ortholog of C. elegans Y69A2AR.S gene product Y69A2AR.17 Y69A2AR.17 Protein of unknown function Y69A2AR.18 Y69A2AR.18 Putative ortholog of C. elegans Y69A2AR.R gene product Y69A2AR.19 Y69A2AR.19 Putative ortholog of C. elegans Y69A2A_2991.A gene product Y69A2AR.2 ric-8;synembryn;Y69A2AR.2 Has a role in synaptic transmission and early embyogenesis Y69A2AR.21 Y69A2AR.21 Putative ortholog of C. elegans Y69A2AR.N gene product Y69A2AR.3 Y69A2AR.3 Protein with strong similarity to C. elegans Y69A2AR.EE gene product Y69A2AR.31 Y69A2AR.31 Putative ortholog of C. elegans Y69A2A_7025.B gene product Y69A2AR.6 Y69A2AR.6 Putative ortholog of C. elegans Y69A2A_7278.E gene product Y69A2AR.7 Y69A2AR.7 Putative ortholog of C. elegans Y69A2A_7278.E gene product Y69A2AR.C Y69A2AR.30;Y69A2AR.C Putative ortholog of C. elegans mdf-2 gene product Y69A2AR.CC Y69A2AR.5;Y69A2AR.CC Putative ortholog of C. elegans Y69A2A_7278.F gene product Y69A2AR.DD Y69A2AR.4;Y69A2AR.DD Putative ortholog of C. elegans K11G12.3 gene product Y69A2AR.E Y69A2AR.28;Y69A2AR.E Protein with strong similarity to C. elegans Y69A2A_7278.J gene product Y69A2AR.F Y69A2AR.27;Y69A2AR.F Protein of unknown function Y69A2AR.FF Y69A2AR.1;Y69A2AR.FF Putative ortholog of C. elegans Y69A2A_3269.A gene product Y69A2AR.G Y69A2AR.26;Y69A2AR.G Putative ortholog of C. elegans Y69A2A_7278.L gene product Y69A2AR.J Y69A2AR.25;Y69A2AR.J Putative ortholog of C. elegans Y69A2AR.13 gene product Y69A2AR.K Y69A2AR.24;Y69A2AR.K Protein of unknown function Y69A2AR.L Y69A2AR.23;Y69A2AR.L Protein of unknown function Y69A2AR.M Y69A2AR.22;Y69A2AR.M Protein of unknown function Y69A2AR.Q Y69A2AR.20;Y69A2AR.Q Protein with strong similarity to C. elegans R03H10.9 gene product Y69A2AR.U Y69A2AR.14;Y69A2AR.U Putative ortholog of C. elegans Y69A2A_1783.C gene product Y69A2AR.V Y69A2AR.13;Y69A2AR.V Putative ortholog of C. elegans Y69A2AR.25 gene product Y69A2AR.W Y69A2AR.12;Y69A2AR.W Protein with strong similarity to C. elegans Y69A2A_1783.C gene product Y69A2AR.Y Y69A2AR.9;Y69A2AR.Y Protein with moderate similarity to C. elegans Y54G2A.13 gene product Y69A2AR.Z Y69A2AR.8;Y69A2AR.Z Protein with strong similarity to C. elegans Y69A2AR.12 gene product Y69E1A.2 Y69E1A.B;Y69E1A.2 Protein of unknown function, has strong similarity to uncharacterized C. elegans Y59E9AL.3 Y69E1A.5 Y69E1A.E;Y69E1A.5 Member of the phosphatidylethanolamine-binding protein family, which may be involved in membrane remodeling during growth and maturation, has low similarity to phosphatidylethanolamine binding protein (rat Pbp), which enhances acetylcholine synthesis Phosphatidylethanolamine-binding protein Y69E1A.6 Y69E1A.6 Member of the 7-transmembrane chemoreceptor family of G-protein coupled receptors (GPCR), has low similarity to uncharacterized C. elegans C41G6.10 7TM chemoreceptor, sri family Y69E1A.8 Y69E1A.H;Y69E1A.8 Protein of unknown function Y69E1A.A Y69E1A.1;Y69E1A.A Protein of unknown function, has very strong similarity to uncharacterized C. elegans T16A9.5 Y69E1A.C Y69E1A.3;Y69E1A.C Protein containing a protein kinase domain and a Src homology 2 (SH2) domain, which are regulatory modules of intracellular signaling, has a region of low similarity to fer (fps/fes related) tyrosine kinase (mouse Fert2) Y69E1A.D Y69E1A.4;Y69E1A.D Member of the serine or threonine protein phosphatase family, has moderate similarity to protein serine-threonine phosphatase PP1 (S. cerevisiae Glc7p), which is required for glucose repression, vesicle trafficking, and septin organization during meiosis Y69E1A.G Y69E1A.7;Y69E1A.G Member of the major intrinsic protein (MIP) family, which are transmembrane channels, has moderate similarity to aquaporin 7 (human AQP7), which facilitates transport of water and glycerol Y69F12A.1 Y69F12A.1 Putative paralog of C. elegans Y69F12A_449.C protein kinase Y69F12A.2 Y69F12A.2 Putative ortholog of S. cerevisiae ALD4 gene product (Mitochondrial aldehyde dehydrogenase) aldehyde dehydrogenase Y69H2.1 Y69H2.B;Y69H2.1 Protein of unknown function, has weak similarity to uncharacterized C. elegans B0546.5 Y69H2.12 Y69H2.12 Protein of unknown function, contains EGF-like domain EGF-like domain Y69H2.13 Y69H2.13 Putative ortholog of C. elegans Y69H2.2 gene product Y69H2.3 Y69H2.3 Predicted protein with no known information Y69H2.5 Y69H2.5 Protein with moderate similarity to C. elegans C10G8.4 gene product Y69H2.9 Y69H2.9 Protein with strong similarity to C. elegans Y17D7C.2 gene product Y69H2.C Y69H2.2;Y69H2.C Member of the amiloride-sensitive sodium channel family, contains seven epidermal growth factor (EGF)-like domains, has a region of low similarity to a region of mouse Notch1, which is a transcriptional regulator involved in development Y69H2.F Y69H2.11;Y69H2.F Member of the amiloride-sensitive sodium channel family, contains seven epidermal growth factor (EGF)-like domains, has a region of low similarity to a region of mouse Notch1, which is a transcriptional regulator Y69H2.G Y69H2.4;Y69H2.G Protein containing four trypsin inhibitor-like cysteine rich domains, has weak similarity to a region of notch (Drosophila) homolog 2 (human NOTCH2), which interacts with the transcriptional coactivator human MAML1 Y69H2.H Y69H2.10;Y69H2.H Protein containing three trypsin inhibitor-like cysteine rich domains Y69H2.I Y69H2.6;Y69H2.I Member of the ubiquitin-conjugating enzyme (E2) family, which catalyze the covalent attachment of ubiquitin to target proteins Y69H2.K Y69H2.7;Y69H2.K Protein with weak similarity to C. elegans Y69H2.J gene product Y69H2.L Y69H2.8;Y69H2.L Protein containing nuclear hormone receptor ligand-binding and C4-type zinc finger domains, has low similarity to estrogen-related receptor beta (human ESRRB), which represses glucocorticoid receptor-mediated transcription Y6B3A.1 Y6B3A.1 Putative ortholog of S. cerevisiae SEC7 gene product (Component of non-clathrin vesicle coat required for protein trafficking within the Golgi) Sec7 domain; This gene encodes a protein predicted by Eisenberg and coworkers, with 52% accuracy, to be mitochondrial. Y6B3B.1 Y6B3B.1 Large protein of unknown function, has weak similarity to S. cerevisiae nuclear pore protein Nup159p, has weak similarity to human triadin and hevin Y6B3B.10 Y6B3B.10 Protein of unknown function, has moderate similarity to uncharacterized longevity assurance homolog 1 (human LASS1) Y6B3B.11 Y6B3B.11 Protein with similarity to C-3 sterol dehydrogenase 3-beta hydroxysteriod dehydrogenase/isomerase family Y6B3B.3 Y6B3B.3 Protein of unknown function, possible pseudogene, has strong similarity to C. elegans M70.1 Y6B3B.4 Y6B3B.4 Protein with weak similarity to C. elegans Y11D7A.14 (Putative myosin, has strong similarity to S. cerevisiae, D. melanogaster and human myosin heavy chain) Y6B3B.5 Y6B3B.5 Member of the inositol monophosphatase family, which participate in the inositol phosphate second messenger signaling pathway, has a region of low similarity to 3'(2') 5'-bisphosphate nucleotidase (rat Bpnt1), which is a bifunctional phosphatase Inositol monophosphatase family; This gene encodes a protein predicted by Eisenberg and coworkers, with 68% accuracy, to be mitochondrial. Y6B3B.6 Y6B3B.6 Protein of unknown function Y6B3B.7 Y6B3B.7 Protein of unknown function Y6B3B.8 Y6B3B.8 Member of the Tc3 Transposase protein family transposase Y6B3B.9 Y6B3B.9 Protein of unknown function Y6D11A.1 Y6D11A.1 Putative ortholog of H. sapiens ARC34 (ARP2/3 protein complex subunit 34) Y6D11A.2 Y6D11A.2 Putative ortholog of C. elegans Y6D11A_150.A gene product Y6D1A.1 Y6D1A.1 Protein of unknown function, has moderate similarity to C. elegans Y6D1A.D Y6D1A.2 Y6D1A.2 Protein with weak similarity to H. sapiens ARFD1 (ADP-ribosylation factor domain protein 1, 64kD) Zinc finger, C3HC4 type (RING finger) Y6E2A.1 Y6E2A.1 Member of the 7-transmembrane chemoreceptor family of G-protein coupled receptors (GPCR), has low similarity to a region of C. elegans ODR-10, which is a G protein-coupled receptor involved in odorant response Y6E2A.2 Y6E2A.2 Member of the 7-transmembrane chemoreceptor family of G-protein coupled receptors (GPCR), has low similarity to C. elegans ODR-10, which is a G protein-coupled receptor involved in odorant response Y6E2A.3 Y6E2A.3 Protein of unknown function, has weak similarity to C. elegans Y6E2A.5 Y6E2A.4 Y6E2A.4 Protein of unknown function Y6E2A.5 Y6E2A.5 Protein of unknown function, has weak similarity to C. elegans F53H2.1 Y6E2A.6 Y6E2A.6 Member of the 7-transmembrane chemoreceptor family of G-protein coupled receptors (GPCR), has high similarity to uncharacterized C. elegans F57E7.3 Y6E2A.7 Y6E2A.7 Protein with weak similarity to C. elegans Y6E2A.5 gene product Y6E2A.8 Y6E2A.8 Protein of unknown function Y6E2A.9 Y6E2A.9 Protein of unknown function, has high similarity to uncharacterized C. elegans AH6.2 Y6G8.1 Y6G8.1 Protein containing a DUF216 domain of unknown function, has moderate similarity to uncharacterized C. elegans Y68A4A.2 Y6G8.2 Y6G8.2 Protein containing three DUF38 domains of unknown function and an F-box domain, which serve as a link between a target protein and a ubiquitin-conjugating enzyme, has strong similarity to uncharacterized C. elegans Y20C6A.1 This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins; this gene's encoded protein also contains an FTH/DUF38 motif, which may also mediate protein-protein interaction. Y6G8.3 Y6G8.3 Protein containing three C2H2 type zinc finger domains, which bind nucleic acids, has a region of moderate similarity to a region of C. elegans HAM-2, which is a putative transcription factor required for migration of hermaphrodite-specific neurons Zinc finger, C2H2 type (2 domains) Y70C5A.2 Y70C5A.2 Protein containing an F-box domain, which serve as a link between a target protein and a ubiquitin-conjugating enzyme, and a DUF38 domain of unknown function, has weak similarity to uncharacterized C. elegans F42G2.4 Y70C5B.1 Y70C5B.1 Putative ortholog of C. elegans W06G6.12 gene product Y70C5C.1 Y70C5C.1 Protein of unknown function, has low similarity to a region of insulin-degrading enzyme (receptor accessory factor, insulinase, human IDE), which degrades insulin, TGF alpha (human TGFA) and amyloid beta (human APP) Y70C5C.2 Y70C5C.2 Member of the C-type lectin protein family CUB domain, Lectin C-type domain short and long forms Y70C5C.3 Y70C5C.3 Member of an uncharacterized protein famil; may be anchored to the membrane of a secretory vesicle or the Golgi apparatus Y70C5C.4 Y70C5C.4 Member of the 7-transmembrane chemoreceptor family of G-protein coupled receptors (GPCR), has high similarity to uncharacterized C. elegans F57E7.3 Y70C5C.5 Y70C5C.5 Protein of unknown function, has high similarity to uncharacterized C. elegans T08G3.4 Y70C5C.6 Y70C5C.6 Protein containing a nuclear hormone receptor C4-type zinc finger domain, has a region of low similarity to a region of peroxisome proliferative activated receptor alpha (mouse Ppara), which functions in lipid homeostasis and the cellular fasting response Zinc finger, C4 type (two domains) Y70D2.A Y70D2A.2;Y70D2.A Protein of unknown function, has low similarity to uncharacterized C. elegans C14C11.3 Y70D2.B Y70D2A.1;Y70D2.B Member of the rhodopsin family of G-protein coupled receptors (GPCR), has low similarity to uncharacterized C. elegans B0563.6 Y70G10A.2 Y70G10A.2 Protein of unknown function, has low similarity to uncharacterized C. elegans F25D7.5 EGF-like domain Y70G10A.3 Y70G10A.3 Protein containing organic anion transporter polypeptide (OATP) family C-terminus and N-terminus domains, has moderate similarity to human SLC21A12, which is an organic anion transporter that transports thyroid hormone by a sodium-independent process Y71A12B.10 Y71A12B.10 Putative ortholog of C. elegans Y71A12B.F gene product Y71A12B.11 Y71A12B.11 Putative ortholog of C. elegans Y71A12D.r gene product Y71A12B.13 Y71A12B.13 Putative ortholog of C. elegans W04A8.1 gene product Y71A12B.2 Y71A12B.2 Putative ortholog of C. elegans Y71A12D.c gene product Y71A12B.3 Y71A12B.3 Putative ortholog of C. elegans Y71A12D.c gene product Y71A12B.4 Y71A12B.4 Putative ortholog of C. elegans Y71A12B.E gene product Y71A12B.5 Y71A12B.5 Putative ortholog of C. elegans Y71A12D.f gene product Y71A12B.6 Y71A12B.6 Putative ortholog of C. elegans Y71A12D.g gene product Y71A12B.7 Y71A12B.7 Putative ortholog of C. elegans F57G4.2 gene product Y71A12B.8 Y71A12B.8 Putative ortholog of C. elegans Y71A12B.J gene product Y71A12B.9 Y71A12B.9 Putative ortholog of C. elegans Y71A12B.H gene product Y71A12B.L Y71A12B.1;Y71A12B.L Protein with similarity to human TAF2A and D. melanogaster TAF250, 250kD TBP-associated factors Y71A12B.P Y71A12B.P Member of the reverse transcriptase protein family, which are RNA-dependent DNA polymerases, has a region of weak similarity to C. elegans ZYG-11, which is required for zygote formation Y71A12B.Q Y71A12B.Q Protein of unknown function, putative paralog of C. elegans Y71A12B.B Y71A12B.T Y71A12B.12;Y71A12B.T Protein of unknown function, has moderate similarity to C. elegans F47G4.2 Y71A12C.1 Y71A12C.1 Protein containing a nuclear hormone receptor ligand-binding domain, has low similarity to C. elegans NHR-51 nuclear hormone receptor Y71A12C.2 Y71A12C.2 Protein of unknown function, has moderate similarity to uncharacterized human MGC15397 Y71D11A.2 Y71D11A.2 Protein with weak similarity to D. melanogaster CG17454 (CG17454 gene product) Y71D11A.3 Y71D11A.3 Protein of unknown function, has strong similarity to C. elegans F58B6.4 Y71D11A.4 Y71D11A.4 Putative paralog of C. elegans F56A4.8 transposase Y71D11A.5 Y71D11A.5 Putative paralog of C. elegans F58G6.4 ion channel protein Y71F9AL.1 Y71F9AL.1 Protein with moderate similarity to D. melanogaster CG1074 (CG1074 gene product) Y71F9AL.10 Y71F9AL.10 Protein with moderate similarity to D. melanogaster CG14435 (CG14435 gene product) Y71F9AL.11 Y71F9AL.11 Protein of unknown function Y71F9AL.12 Y71F9AL.12 Protein of unknown function Y71F9AL.14 Y71F9AL.14 Protein with moderate similarity to D. melanogaster BG:DS00929.1 (Protein of unknown function) Y71F9AL.16 Y71F9AL.16 Putative ortholog of S. cerevisiae ARP3 gene product (Actin-related protein of the ARP2/3 complex, involved in cell polarity and endocytosis) actin Y71F9AL.17 Y71F9AL.17 Putative ortholog of S. cerevisiae COP1 gene product (Coatomer (COPI) complex alpha chain (alpha-COP) of secretory pathway vesicles required for retrograde Golgi to endoplasmic reticulum transport, member of WD (WD-40) repeat family) coatomer, alpha chain; Y71F9AL.17 encodes an alpha subunit of the coatomer (COPI) complex; in mass RNAi assays, Y71F9AL.17 is required for embryonic viability, fertility, normal locomotion, and normally rapid growth. Y71F9AL.18 Y71F9AL.18 Putative ortholog of H. sapiens ADPRT (ADP-ribosyltransferase (NAD+) Y71F9AL.2 Y71F9AL.2 Putative paralog of C. elegans C49C8.1 protein kinase Y71F9AL.3 Y71F9AL.3 Putative paralog of C. elegans F20B4.7 reverse transcriptase Y71F9AL.4 Y71F9AL.4 Protein with strong similarity to C. elegans F20B6.6 protein-tyrosine phosphatase Y71F9AL.5 Y71F9AL.5 Putative paralog of C. elegans Y53G8B.1, related to glutathione S-transferases glutathione S-transferase Y71F9AL.6 Y71F9AL.6 Protein of unknown function Y71F9AL.7 Y71F9AL.7 Protein of unknown function Y71F9AL.8 Y71F9AL.8 Protein of unknown function Y71F9AL.9 Y71F9AL.9 Protein with weak similarity to C. elegans pod-1 (Member of the actin-binding coronin family that is necessary for anteroposterior axis specification in C. elegans) Y71F9AM.3 Y71F9AM.3 Putative ortholog of C. elegans Y71F9AM.D gene product Y71F9AM.4 Y71F9AM.4 Putative ortholog of C. elegans Y71F9AM.B gene product Y71F9AM.5 Y71F9AM.5 Putative ortholog of C. elegans NXT1 gene product Y71F9AM.A Y71F9AM.6;Y71F9AM.A Protein of unknown function Y71F9AR.A Y71F9AR.3;Y71F9AR.A Protein of unknown function Y71F9AR.B Y71F9AR.2;Y71F9AR.B Protein with moderate similarity to H. sapiens LOC51285 (Ris) Y71F9A_294.C rpl-10a;Y71F9AL.13;Y71F9A_294.C Protein with strong similarity to S. cerevisiae RPL1A (Large subunit ribosomal protein L1 (rat L10A) Y71F9A_295.A Y71F9AR.1;Y71F9A_295.A Putative ortholog of C. elegans Y71F9AR.C gene product Y71F9B.1 Y71F9B.1 Protein of unknown function Y71F9B.12 sop-3;Y71F9B.10;Y71F9B.11;Y71F9B.12 Weakly similar to C. elegans unc-89; may modulate WNT signalling Y71F9B.13 Y71F9B.13 Protein of unknown function Y71F9B.14 Y71F9B.14 Protein with moderate similarity to C. elegans F55B11.3 Y71F9B.15 Y71F9B.15 Protein of unknown function, has weak similarity to C. elegans C46E10.1 Y71F9B.16 Y71F9B.16 Protein with weak similarity to C. elegans T03F6.2 gene product This gene encodes a protein containing a DnaJ ('J') domain. Y71F9B.2 Y71F9B.2 Protein with moderate similarity to D. melanogaster CG3641 (CG3641 gene product) Y71F9B.3 Y71F9B.3 Protein with strong similarity to H. sapiens D5S346 (DNA segment, single copy probe LNS-CAI/LNS-CAII (deleted in polyposis) Y71F9B.4 Y71F9B.4;1D295 Protein with moderate similarity to H. sapiens SNRPG (small nuclear ribonucleoprotein polypeptide G) small nuclear ribonucleoprotein Sm G (snRNP core protein G) Y71F9B.5 lin-17;Y71F9B_287.C;Y71F9.5;Y71F9B.5 Protein required for generating asymmetry within male- and female-specific lineages, related to D. melanogaster Frizzled receptor lin-17 encodes one of four C. elegans Frizzled homologs, integral membrane proteins that contain an external cysteine rich domain (CRD) and seven transmembrane domains and that function in a wide variety of species as receptors for Wnt glycoprotein signaling molecules; LIN-17 activity is required for specifying the polarity of a number of asymmetric cell divisions that, in C. elegans, are essential for development of such structures as the vulva, somatic gonad, and tail; LIN-17 is also required for the proper polarity of neuronal migrations along the anterior-posterior axis; genetic interactions indicate that LIN-17 likely functions as a receptor for several different Wnt molecules, including LIN-44 and EGL-20, and that in specifying cell fates, the LIN-17-mediated signaling pathway often functions redundantly with other signaling pathways, including the RTK/Ras pathway; a LIN-17 translational reporter fusion shows membrane-associated expression in all of the Pn.pxx vulval precursor cells, in the descendants of V6 and T in males, in the P11.p and B cells, as well as their daughters, and granddaughters, and weakly in P10.p and its daughters; the reporter fusion does not reveal expression in P7.p, Z1, Z4, and T. Y71F9B.6 Y71F9B.6 Protein with moderate similarity to H. sapiens SPF31 (Homo sapiens SPF31 (SPF31) mRNA, complete cds) Y71F9B.7 Y71F9B.7;plk-2 Putative paralog of C. elegans plk-1; Serine/threonine protein kinase with strong similarity to Drosophila POLO, human PLK, yeast Cdc5p, and other members of the polo family, which are involved in activation of the anaphase-promoting complex in late mitosis Y71F9B.8 Y71F9B.8;1D304 Protein with moderate similarity to C. elegans sym-5 (Putative member of the leucine-rich repeat (LRR) protein family, synthetically lethal with mec-8) Y71F9B.9 Y71F9B.9 Protein with strong similarity to D. melanogaster CG10131 (CG10131 gene product) Y71G10AL.1 Y71G10AL.1 Putative ortholog of C. elegans Y71G10AL.B gene product Y71G10AR.2 Y71G10AR.2 Protein with strong similarity to C. elegans Y71G10AR.C gene product Y71G10AR.3 Y71G10AR.3 Putative ortholog of C. elegans Y71G10AR.A gene product Y71G10AR.D Y71G10AR.1;Y71G10AR.D Protein with weak similarity to D. melanogaster CG11655 (CG11655 gene product) Y71G12A.2 Y71G12A.2 Putative ortholog of C. elegans Y71G12A.D gene product Y71G12A.4 Y71G12A.4 Putative ortholog of C. elegans Y71G12A.B gene product Y71G12A.A Y72A10A.1;Y72A10A.A;Y71G12A.A Protein of unknown function Y71G12A.C Y71G12A.3;Y71G12A.C Protein with moderate similarity to C. elegans tub-1 gene product Y71G12B.1 Y71G12B.1 Protein with weak similarity to C. elegans Y71G12B.28 gene product Y71G12B.10 Y71G12B.10 Protein of unknown function Y71G12B.10 is orthologous to the human gene 3-HYDROXYMETHYL-3-METHYLGLUTARYL-COENZYME A LYASE (HYDROXYMETHYLGLUTARICACIDURIA) (HMGCL; OMIM:246450), which when mutated leads to disease. Y71G12B.11 Y71G12B.11 Protein with moderate similarity to C. elegans ZK370.3 gene product Y71G12B.12 Y71G12B.12 Protein of unknown function Y71G12B.13 Y71G12B.13 Protein of unknown function Y71G12B.15 Y71G12B.15 Protein with strong similarity to C. elegans Y87G2A.9 gene product ubc-3 encodes an E2 ubiquitin-conjugating enzyme orthologous to Saccharomyces cerevisiae and human CDC34 (OMIM:603731) which are involved in regulating protein stability during G1 and G2 cell cycle phase transitions; by homology, UBC-3 is likely required for covalent attachment of ubiquitin to select target proteins to facilitate their degradation; however, as loss of UBC-3 activity via RNA-mediated interference (RNAi) does not result in any abnormalities, the precise role of UBC-3 in C. elegans development and/or behavior is not yet known. Y71G12B.17 Y71G12B.17 Putative ortholog of C. elegans Y54F10AR.1 gene product Y71G12B.18 Y71G12B.18 Putative ortholog of C. elegans W09C3.3 gene product Y71G12B.23 Y71G12B.23 Protein of unknown function Y71G12B.24 Y71G12B.24 Protein with strong similarity to C. elegans ZC410.2 gene product Y71G12B.25 Y71G12B.25 Protein with strong similarity to C. elegans Y51F10.4 gene product Y71G12B.28 Y71G12B.28 Protein with weak similarity to C. elegans Y71G12B.1 gene product Y71G12B.8 Y71G12B.8 Putative ortholog of C. elegans T26G10.1 gene product Y71G12B.9 Y71G12B.9 Protein of unknown function Y71G12B.B Y71G12B.27;Y71G12B.B Protein with strong similarity to C. elegans cks-1 gene product Y71G12B.BB Y71G12B.7;Y71G12B.BB Protein of unknown function Y71G12B.C Y71G12B.26;Y71G12B.C Protein with moderate similarity to C. elegans Y71G12B.25 gene product Y71G12B.CC Y71G12B.6;Y71G12B.CC Protein with weak similarity to C. elegans C01F1.3 gene product Y71G12B.DD Y71G12B.5;Y71G12B.DD Protein with strong similarity to C. elegans F16H6.9 gene product Y71G12B.EE Y71G12B.4;Y71G12B.EE Protein with strong similarity to C. elegans T19B4.1 gene product Y71G12B.FF Y71G12B.3;Y71G12B.FF Protein with strong similarity to C. elegans C14A6.8 gene product Y71G12B.GG Y71G12B.2;Y71G12B.GG Protein with weak similarity to C. elegans Y51F10.4 gene product Y71G12B.M Y71G12B.22;Y71G12B.M Putative ortholog of C. elegans Y116F11B.P gene product Y71G12B.N Y71G12B.21;Y71G12B.N Protein of unknown function Y71G12B.O Y71G12B.20;Y71G12B.O Putative ortholog of C. elegans mab-20 gene product Y71G12B.S Y71G12B.16;Y71G12B.S Protein of unknown function Y71G12B.U Y71G12B.14;Y71G12B.U Protein with moderate similarity to C. elegans ZK652.1 gene product Y71H10A.1 Y71H10A.1 Protein with high similarity to muscle phosphofructokinase (human PFKM), which regulates glucose metabolism and is associated with glycogenosis type VII (Tarui disease) and insulin resistance upon gene mutation, member of the phosphofructokinase family phosphofructokinase; Y71H10A.1 is orthologous to the human gene PHOSPHOFRUCTOKINASE, MUSCLE TYPE (PFKM; OMIM:232800), which when mutated leads to glycogen storage disease VII. Y71H10A.2 Y71H10A.2 Member of the male sterility protein family, has moderate similarity to uncharacterized human FLJ10462 Y71H10B.1 Y71H10B.1 Protein of unknown function, has high similarity to uncharacterized human NT5B Y71H2AL.1 Y71H2AL.1 Protein with strong similarity to C. elegans ZK856.8 gene product Y71H2AL.G Y71H2AL.2;Y71H2AL.G Protein of unknown function Y71H2AM.1 Y71H2AM.1 Protein with moderate similarity to C. elegans C01G10.10 gene product Y71H2AM.11 Y71H2AM.11 Putative ortholog of C. elegans R11H6.1 gene product Y71H2AM.12 Y71H2AM.12 Protein with strong similarity to C. elegans F59B2.7 gene product Y71H2AM.15 Y71H2AM.15 Putative ortholog of C. elegans Y71H2AM.I gene product Y71H2AM.19 Y71H2AM.19 Putative ortholog of C. elegans Y71H2AM.D gene product Y71H2AM.20 Y71H2AM.20 Putative ortholog of C. elegans Y71H2AM.D gene product Y71H2AM.23 Y71H2AM.23 Putative ortholog of C. elegans Y71H2AM.A gene product Y71H2AM.B Y71H2AM.22;Y71H2AM.B Putative ortholog of C. elegans M02F4.5 gene product Y71H2AM.C Y71H2AM.21;Y71H2AM.C Putative ortholog of C. elegans twk-3 gene product Y71H2AM.E Y71H2AM.18;Y71H2AM.E Putative ortholog of C. elegans Y54E10A.9 gene product Y71H2AM.F Y71H2AM.17;Y71H2AM.F Protein of unknown function Y71H2AM.G Y71H2AM.16;Y71H2AM.G Protein with strong similarity to C. elegans T21B6.2 gene product Y71H2AM.J Y71H2AM.14;Y71H2AM.J Putative ortholog of C. elegans K06H6.6 gene product Y71H2AM.K Y71H2AM.13;Y71H2AM.K Putative ortholog of C. elegans F15A8.6 gene product Y71H2AM.M Y71H2AM.10;Y71H2AM.M Protein of unknown function Y71H2AM.N Y71H2AM.9;Y71H2AM.N Protein of unknown function Y71H2AM.O Y71H2AM.8;Y71H2AM.O Protein of unknown function Y71H2AM.P Y71H2AM.7;Y71H2AM.P Protein with strong similarity to C. elegans Y105E8F.b gene product Y71H2AM.R Y71H2AM.6;Y71H2AM.R Protein of unknown function Y71H2AM.S Y71H2AM.5;Y71H2AM.S Protein of unknown function Y71H2AM.T Y71H2AM.4;Y71H2AM.T Protein of unknown function Y71H2AM.U Y71H2AM.3;Y71H2AM.U Putative ortholog of C. elegans Y71H2_387.A gene product Y71H2AM.V Y71H2AM.2;Y71H2AM.V Protein with moderate similarity to C. elegans Y105E8F.b gene product Y71H2AR.1 Y71H2AR.1 Protein of unknown function Y71H2AR.A Y71H2AR.2;Y71H2AR.A Putative ortholog of C. elegans Y71H2_387.A gene product Y71H2B.1 Y71H2B.1 Putative paralog of C. elegans Y65B4A.I Y71H2B.10 Y71H2B.10 Putative ortholog of S. cerevisiae APL2 gene product - Beta-adaptin, large subunit of the clathrin-associated protein (AP) complex; RNA interference leads to 100% lethality The apt-3 gene encodes an adaptin: specifically, it encodes an ortholog of the beta1/2 subunit of adaptor protein complex 1 (AP-1) that affects fertility and embryonic viability. Y71H2B.11 Y71H2B.11 Protein of unknown function Y71H2B.2 Y71H2B.2 Protein with weak similarity to D. melanogaster CG8069 (CG8069 gene product) Y71H2B.3 Y71H2B.3 Protein with moderate similarity to H. sapiens IGBP1 (immunoglobulin (CD79A) binding protein 1) Y71H2B.4 Y71H2B.4 Protein of unknown function Y71H2B.5 Y71H2B.5 Protein with weak similarity to D. melanogaster CG8078 (CG8078 gene product) Y71H2B.6 Y71H2B.6 Protein with weak similarity to D. melanogaster CG5546 (CG5546 gene product) Y71H2B.7 Y71H2B.7 Protein with weak similarity to C. elegans egl-30 (Guanine nucleotide-binding protein alpha subunit involved in regulation of muscle contraction) Y71H2B.8 Y71H2B.8 Protein of unknown function Y71H2_389.E Y71H2_389.E Protein with high similarity to adaptor protein complex AP-1 beta 1 subunit (rat Ap1b1), which participates in clathrin-coated vesicle endocytosis, contains an adaptin C-terminal domain and three clathrin-associated adaptin N-terminal domains Y71H9A.1 Y71H9A.1 Protein with strong similarity to C. elegans F20A1.7, a member of the 4 TM potassium channel protein family Y71H9A.2 Y71H9A.2 Protein with high similarity to erythrocyte membrane protein band 7.2 (stomatin, human EPB72), which may serve in ion channel permeability, mechanoreception, lipid domain organization and stomatocytosis, member of the SPFH domain or Band 7 family Erythrocyte band 7 protein Y71H9A.3 sto-4;T04F8.5;Y71H9A.3 Protein with high similarity to erythrocyte membrane protein band 7.2 (human EPB72), which may control of ion channel permeability and mechanoreception and is associated with hereditary stomatocytosis, member of the SPFH domain or Band 7 family Band 7 family Y73B3A.1 Y73B3A.1 Putative ortholog of C. elegans F15E6.1 gene product Y73B3A.12 Y73B3A.12 Protein with strong similarity to C. elegans Y73B3A.M gene product Y73B3A.15 Y73B3A.15 Putative ortholog of C. elegans B0391.6 gene product Y73B3A.16 Y73B3A.16 Putative ortholog of C. elegans C16A11.3 gene product Y73B3A.18 Y73B3A.18 Putative ortholog of C. elegans Y73B3A.D gene product Y73B3A.2 Y73B3A.2 Protein with strong similarity to C. elegans Y24D9A.8 gene product Y73B3A.20 Y73B3A.20 Protein of unknown function Y73B3A.21 Y73B3A.21 Putative ortholog of C. elegans Y73B3A.A gene product Y73B3A.3 Y73B3A.3 Putative ortholog of C. elegans M70.B gene product Y73B3A.5 Y73B3A.5 Putative ortholog of C. elegans lin-1 gene product Y73B3A.6 Y73B3A.6 Putative ortholog of C. elegans F30F8.4 gene product transposase Y73B3A.9 Y73B3A.9 Putative ortholog of C. elegans Y73B3A.P gene product Y73B3A.C Y73B3A.19;Y73B3A.C Putative ortholog of C. elegans B0513.7 gene product Y73B3A.E Y73B3A.17;Y73B3A.E Putative ortholog of C. elegans Y24D9A_29.E gene product Y73B3A.I Y73B3A.14;Y73B3A.I Protein with strong similarity to C. elegans B0391.9 gene product Y73B3A.J Y73B3A.13;Y73B3A.J Putative ortholog of C. elegans F28F8.7 gene product Y73B3A.N Y73B3A.11;Y73B3A.N Protein with moderate similarity to C. elegans Y48G1BM.5 gene product Y73B3A.O Y73B3A.10;Y73B3A.O Protein with strong similarity to C. elegans F54A3.3 gene product Y73B3A.R Y73B3A.8;Y73B3A.R Protein of unknown function Y73B3A.S Y73B3A.7;Y73B3A.K;Y73B3A.S Protein of unknown function Y73B3A.X Y73B3A.4;Y73B3A.X Putative ortholog of C. elegans M70.5 gene product Y73B3B.4 Y73B3B.4 Putative ortholog of C. elegans Y73B3B.B gene product Y73B3B.A Y73B3B.5;Y73B3B.A Protein of unknown function Y73B3B.C Y73B3B.3;Y73B3B.C Protein with moderate similarity to C. elegans T28A8.3 gene product Y73B3B.D Y73B3B.2;Y73B3B.D Putative ortholog of C. elegans C47E8.8 gene product Y73B3B.E Y73B3B.1;Y73B3B.E Putative ortholog of C. elegans Y57A10A.5 gene product Y73B6A.1 Y73B6A.1 Putative haspin-like protein kinase protein kinase Y73B6A.2 Y73B6A.2 Putative paralog of C. elegans C05C12.1 protein kinase Y73B6A.4 smg-7;Y73B6A.4 Protein involved in nonsense-mediated mRNA decay Y73B6A.5 lin-45;raf-1;Y73B6A.5 Raf kinase, a serine/threonine protein kinase required for L1 larval viability and vulval development protein kinase; The lin-45 gene encodes an ortholog of the vertebrate protein RAF which is required for larval viability, fertility and the induction of vulval cell fates. Y73B6BL.1 Y73B6BL.1 Putative ortholog of C. elegans F21C3.2 gene product Y73B6BL.1 is orthologous to the human gene TRANSTHYRETIN (PREALBUMIN, AMYLOIDOSIS TYPE I) (TYR; OMIM:176300), which when mutated leads to disease. Y73B6BL.13 mif-4;Y73B6BL.Q;Y73B6BL.13 Member of the Macrophage migration inhibitory factor (MIF) family Y73B6BL.18 Y73B6BL.18 Putative ortholog of C. elegans Y73B6BL.j gene product Y73B6BL.19 Y73B6BL.19 Putative ortholog of C. elegans Y73B6BL.j gene product Y73B6BL.19 encodes a SHAL/Kv4 ortholog, which encodes voltage-dependent potassium channels expressed in muscle. Y73B6BL.2 Y73B6BL.2 Protein required for oogenesis Y73B6BL.23 Y73B6BL.23 Putative ortholog of C. elegans ZK616.5 gene product Y73B6BL.27 Y73B6BL.27 Protein with strong similarity to C. elegans Y73B6BL.b gene product Y73B6BL.28 Y73B6BL.28 Protein with strong similarity to C. elegans Y73B6BL.a gene product Y73B6BL.29 Y73B6BL.29 Putative ortholog of C. elegans Y73B6BL.x gene product Y73B6BL.3 Y73B6BL.3 Protein of unknown function Y73B6BL.30 Y73B6BL.30 Protein with moderate similarity to C. elegans Y73B6BL.y gene product Y73B6BL.31 Y73B6BL.31 Protein of unknown function Y73B6BL.32 Y73B6BL.32 Protein with weak similarity to C. elegans F40F8.9 gene product U6 small nuclear RNA-associated Sm-like protein LSm8 Y73B6BL.5 Y73B6BL.5 Putative ortholog of C. elegans Y73B6BL.y gene product Y73B6BL.6 Y73B6BL.6 Putative ortholog of C. elegans Y73B6BL.x gene product Y73B6BL.C Y73B6BL.26;Y73B6BL.C Putative ortholog of C. elegans C04C3.2 gene product Y73B6BL.D Y73B6BL.25;Y73B6BL.D Protein predicted to contain a glycosylphosphatidylinositol (GPI) lipid anchor Y73B6BL.E Y73B6BL.24;Y73B6BL.E Putative ortholog of C. elegans Y73B6BL.25 gene product Y73B6BL.G Y73B6BL.22;Y73B6BL.G Protein of unknown function Y73B6BL.H Y73B6BL.21;Y73B6BL.H Protein with moderate similarity to C. elegans mom-5 gene product Y73B6BL.I Y73B6BL.20;Y73B6BL.I Protein of unknown function Y73B6BL.L Y73B6BL.17;Y73B6BL.L Protein with strong similarity to C. elegans msp-32 gene product Y73B6BL.M Y73B6BL.16;Y73B6BL.M Putative ortholog of C. elegans F38E9.4 gene product Y73B6BL.N Y73B6BL.15;Y73B6BL.N Putative ortholog of C. elegans B0478.2 gene product Y73B6BL.O Y73B6BL.14;Y73B6BL.O Protein with moderate similarity to C. elegans K07C5.3 gene product Y73B6BL.R Y73B6BL.12;Y73B6BL.R Putative ortholog of C. elegans Y47H9C.5 gene product Y73B6BL.S Y73B6BL.11;Y73B6BL.S Putative ortholog of C. elegans T13A10.12 gene product Y73B6BL.T Y73B6BL.10;Y73B6BL.T Putative ortholog of C. elegans T13A10.12 gene product Y73B6BL.U H1.2;Y73B6BL.9;Y73B6BL.U Histone H1 Y73B6BL.W csp-2;Y73B6BL.7;Y73B6BL.W Protein containing two interleukin-1 beta converting enzyme (ICE)-like protease (caspase) p10 domains and two interleukin-1 beta converting enzyme (ICE)-like protease (caspase) p20 domains, has a region of low similarity to C. elegans CED-3 Y73B6BL.Z Y73B6BL.4;Y73B6BL.Z Protein related to a H. sapiens calcium-independent phospholipase A Y73B6BR.A Y73B6BR.1;Y73B6BR.A Protein of unknown function, has moderate similarity to C. elegans F14B8.5 Y73C8A.1 Y73C8A.1 Member of the 7-transmembrane chemoreceptor family of G-protein coupled receptors (GPCR), has low similarity to C. elegans ODR-10, which is involved in odorant response 7TM chemoreceptor, str family Y73C8B.1 Y73C8B.1 Protein of unknown function, putative paralog of C. elegans K08D9.4 Y73C8B.2 Y73C8B.2 Protein of unknown function, putative paralog of C. elegans Y73C8B.3 Y73C8B.3 Y73C8B.3 Protein of unknown function, putative paralog of C. elegans Y73C8B.2 Y73C8B.D lag-2;let-461;sel-3;Y73C8B.4;Y73C8B.D Ligand of the Delta/Serrate/lag-2 (DSL) family, appears to interact with LIN-12 and GLP-1 Notch receptors to influence cell fate decisions Y73C8C.10 Y73C8C.10 Member of the NADH:flavin oxidoreductase or NADH oxidase family, which reduce a range of alternative electron acceptors, has a region of low similarity to a region of C. albicans Ebp1p, which is an oxidoreductase with estrogen-binding properties Y73C8C.11 Y73C8C.11 Protein of unknown function, putative paralog of C. elegans C50H11.16 7TM chemoreceptor, str family Y73C8C.2 Y73C8C.2 Protein containing a C-type lectin domain, which mediate calcium-dependent carbohydrate recognition, has high similarity to uncharacterized C. elegans ZK896.7 Y73C8C.3 Y73C8C.3 Protein of unknown function, has high similarity to uncharacterized C. elegans Y73C8C.8 Y73C8C.4 Y73C8C.4 Protein of unknown function, has high similarity to uncharacterized C. elegans C50H11.17 Y73C8C.5 Y73C8C.5 Member of the 7-transmembrane chemoreceptor family of G-protein coupled receptors (GPCR), has high similarity to uncharacterized C. elegans Y73C8C.6 7TM chemoreceptor, str family Y73C8C.6 Y73C8C.6 Member of the 7-transmembrane chemoreceptor family of G-protein coupled receptors (GPCR), has high similarity to uncharacterized C. elegans Y73C8C.11 7TM chemoreceptor, str family Y73C8C.7 Y73C8C.7 Protein of unknown function, has high similarity to ucharacterized C. elegans T22B2.1 Y73C8C.8 Y73C8C.8 Protein of unknown function, has high similarity to uncharacterized C. elegans T22B2.1 Y73C8C.9 Y73C8C.9 Protein containing a DUF32 domain of unknown function, has high similarity to uncharacterized C. elegans T16H12.8, 7TM chemoreceptor, srt family Y73E7A.1 Y73E7A.1 Protein of unknown function Y73E7A.2 Y73E7A.2 Putative ortholog of C. elegans Y73E7A.G gene product Y73E7A.8 Y73E7A.8 Protein with weak similarity to C. elegans F23H12.5 gene product Y73E7A.B Y73E7A.7;Y73E7A.B Protein with strong similarity to C. elegans W02B12.11 gene product Y73E7A.C Y73E7A.6;Y73E7A.C Putative ortholog of C. elegans bc1 gene product Y73E7A.D Y73E7A.5;Y73E7A.D Putative ortholog of C. elegans C24H12.9 gene product Y73E7A.E Y73E7A.4;Y73E7A.E Protein with weak similarity to C. elegans K03A11.2 gene product Y73E7A.F Y73E7A.3;Y73E7A.F Protein of unknown function Y73F4A.1 Y73F4A.1 Protein of unknown function, has low similarity to uncharacterized C. elegans Y73F4A.3 Y73F4A.2 Y73F4A.2 Protein of unknown function, has moderate similarity to uncharacterized C. elegans Y73F4A.3 Y73F4A.3 Y73F4A.3 Protein of unknown function, has moderate similarity to uncharacterized C. elegans Y73F4A.2 Y73F8A.10 Y73F8A.10 Protein of unknown function, putative paralog of C. elegans Y73F8A.I Y73F8A.11 Y73F8A.11 Putative paralog of C. elegans Y73F8A.J Y73F8A.12 Y73F8A.12 Protein of unknown function, has strong similarity to C. elegans Y73F8A.14 Y73F8A.13 Y73F8A.13 Protein of unknown function, putative paralog of C. elegans Y73F8A.L Y73F8A.14 Y73F8A.14 Protein of unknown function, has strong similarity to C. elegans Y73F8A.12 Y73F8A.15 Y73F8A.15 Protein of unknown function, has strong similarity to C. elegans Y73F8A.N Y73F8A.16 Y73F8A.16 Putative paralog of C. elegans Y73F8A.17 Y73F8A.17 Y73F8A.17 Putative paralog of C. elegans Y73F8A.16 Y73F8A.18 Y73F8A.18 Protein of unknown function, putative paralog of C. elegans Y73F8A.Q Y73F8A.19 Y73F8A.19 Putative paralog of C. elegans Y73F8A.S Y73F8A.2 Y73F8A.2 Putative paralog of C. elegans Y73F8A.C neurotransmitter-gated ion-channel protein Y73F8A.20 Y73F8A.20 Protein of unknown function, putative paralog of C. elegans Y73F8A.V Y73F8A.21 Y73F8A.21 Putative paralog of C. elegans Y73F8A.W Y73F8A.22 Y73F8A.Z;Y73F8A.22 Protein of unknown function, has strong similarity to uncharacterized C. elegans Y116A8C.1 Y73F8A.23 Y73F8A.Y;Y73F8A.23 Protein of unknown function, has moderate similarity to uncharacterized C. elegans Y73F8A.Z Y73F8A.24 Y73F8A.24 Protein with strong similarity to S. cerevisiae TFB2 (Component of RNA polymerase II transcription initiation TFIIH (factor b), 55 kDa subunit) Y73F8A.25 Y73F8A.25 Protein of unknown function, has weak similarity to C. elegans F56H9.1 Y73F8A.26 Y73F8A.26 Protein with moderate similarity to H. sapiens CASP (cartilage-associated protein) Y73F8A.27 Y73F8A.27 Protein with moderate similarity to S. cerevisiae YAH1 (Protein with similarity to adrenodoxin and ferrodoxin) Y73F8A.28 Y73F8A.28 Putative paralog of C. elegans ZK856.2 (TcA transposase) Tc1 transposase Y73F8A.29 Y73F8A.29 Putative paralog of C. elegans Y95B8A.3 Y73F8A.3 Y73F8A.3 Protein of unknown function, putative paralog of C. elegans T03D3.14 7tm receptor protein Y73F8A.30 Y73F8A.30 Putative paralog of C. elegans deg-3 (Subunit of the nicotinic acetylcholine receptor and member of the neurotransmitter-gated ion-channel protein family) Y73F8A.31 Y73F8A.31 Protein with strong similarity to C. elegans T25E12.5 Y73F8A.32 Y73F8A.32 Protein with moderate similarity to C. elegans M116.2 (Putative paralog of C. elegans Tc5 transposase T13C2.1) Y73F8A.33 Y73F8A.33 Protein of unknown function, has strong similarity to C. elegans F52C6.14 Y73F8A.34 Y73F8A.34 Putative ortholog of D. melanogaster ari (ariadne) Y73F8A.35 Y73F8A.35 Putative paralog of C. elegans R03G8.3 Y73F8A.5 Y73F8A.5 Putative paralog of C. elegans Y73F8A.E Y73F8A.6 Y73F8A.6 Protein of unknown function, putative paralog of C. elegans Y73F8A.F Y73F8A.8 Y73F8A.8 Putative paralog of C. elegans Y73F8A.G The protein product of this gene is predicted to contain a glutamine/asparagine (Q/N)-rich ('prion') domain, by the algorithm of Michelitsch and Weissman (as of the WS77 release of WormBase, i.e., in wormpep77). Y73F8A.9 Y73F8A.9 Putative paralog of C. elegans Y73F8A.G The protein product of this gene is predicted to contain a glutamine/asparagine (Q/N)-rich ('prion') domain, by the algorithm of Michelitsch and Weissman (as of the WS77 release of WormBase, i.e., in wormpep77). Y73F8A.A pkd-2;Y73F8A.1;Y73F8A.A Similarity to H. sapiens PKD2, expressed in male-specific neurons Y74C10AL.A Y74C10AL.2;Y74C10AL.A Protein with moderate similarity to H. sapiens C21orf4 (chromosome 21 open reading frame 1) Y74C10AL.B Y74C10AL.1;Y74C10AL.B Protein of unknown function, has weak similarity to C. elegans Y53G8AM.H Y74C10AM.A Y74C10AM.1;Y74C10AM.A Protein with strong similarity to S. cerevisiae ATM1 (Member of the ATP-binding cassette (ABC) superfamily of membrane transporters, component of the mitochondrial inner membrane) Y74C10AR.A Y74C10AR.2;Y74C10AR.A Protein of unknown function Y74C10AR.B Y74C10AR.1;Y74C10AR.B Putative ortholog of D. melanogaster Trip1 (Trip1) Y74C9A.1 Y74C9A.1 Protein of unknown function, has weak similarity to C. elegans R12C12.7 Y74C9A.2 Y74C9A.2 Protein of unknown function Y74C9A.3 Y74C9A.3 Protein with moderate similarity to H. sapiens AD-003 (AD-003 protein) Y74C9A.4 Y74C9A.4 Protein with moderate similarity to C. elegans D1014.8 DNA-binding protein Y74C9A.5 Y74C9A.5 Protein with weak similarity to H. sapiens PA26 (p53 regulated PA26 nuclear protein) Y74E4A.1 Y74E4A.1 Protein with strong similarity to C. elegans C33G3.3 Y75B12A.2 Y75B12A.2 Protein of unknown function, has high similarity to uncharacterized C. elegans AH10.2 Y75B12B.1 Y75B12B.1 Protein with moderate similarity to C. elegans F47H4.4 gene product Y75B12B.2 cyp-7;Y75B12B.2 Cyclophilin-related peptidylprolyl cis-trans-isomerase Peptidyl-prolyl cis-trans isomerases; cyp-7 encodes a cyclophilin A isoform; while not tested peptidyl-prolyl isomerase activity in vitro, it is very similar to CYP-3 and closely resembles the prototypical CypA, and is therefore likely to be a member of the cytosolic CsA-binding cyclophilin subfamily; CYP-7 was required for embryonic viability in one set of mass RNAi assays. Y75B12B.3 Y75B12B.3 Protein of unknown function Y75B12B.4 Y75B12B.4 Protein containing a BTB (BR-C, ttk and babor) or POZ (Pox virus and zinc finger) domain, which are found in some DNA and actin binding proteins and may mediate protein-protein interactions, has low similarity to uncharacterized C. elegans F52H3.3 BTB (also known as BR-C/Ttk) domain. Y75B12B.5 cyp-3;Y75B12B.5 Cyclophilin-related peptidylprolyl cis-trans-isomerase that is inhibited by cyclosporin A Peptidyl-prolyl cis-trans isomerases; cyp-3 encodes an abundantly expressed cyclophilin A isoform with peptidyl-prolyl isomerase activity in vitro, which closely resembles the prototypical CypA and is thus likely to be a member of the cytosolic CsA-binding cyclophilin subfamily; cyp-3 is exclusively expressed in the single anterior excretory cell, and is dispensable for viability and gross morphology in mass RNAi screens. Y75B12B.6 Y75B12B.6 Protein containing phosphatidylinositol-specific phospholipase C X and C Y domains, which are involved in signal transduction, has low similarity to phospholipase C delta 1 (rat Plcd1), which hydrolyzes phosphatidylinositol 4,5-bisphosphate Phosphatidylinositol-specific phospholipase C, X domain, Phosphatidylinositol-specific phospholipase C, Y domain Y75B12B.7 Y75B12B.7 Protein of unknown function, has low similarity to uncharacterized C. elegans T24A6.14 7TM chemoreceptor, srw family Y75B12B.8 Y75B12B.8 Protein of unknown function, has very strong similarity to uncharacterized C. elegans C41G6.13 Y75B12B.9 Y75B12B.9 Protein of unknown function, has very strong similarity to uncharacterized C. elegans C41G6.1 Y75B7AL.A Y75B7AL.4;Y75B7AL.A Putative ortholog of C. elegans K09H11.3 gene product Y75B7AL.B Y75B7AL.3;Y75B7AL.B Putative ortholog of C. elegans snt-1 gene product Y75B7AL.C Y75B7AL.2;Y75B7AL.C Protein of unknown function Y75B7AL.D Y75B7AL.1;Y75B7AL.D Protein with strong similarity to C. elegans M04G7.3 gene product Y75B7AR.1 Y75B7AR.1 Protein with strong similarity to C. elegans Y75B7AR.A gene product Y75B7B.1 Y75B7B.1 Protein of unknown function, putative paralog of C. elegans C01G5.3 Y75B7B.2 Y75B7B.2 Protein of unknown function, putative paralog of C. elegans B0350.2D Y75B8A.10 Y75B8A.N;Y75B8A.10 Protein containing a C3HC4 type (RING) zinc finger, which may mediate protein-protein interactions Zinc finger, C3HC4 type (RING finger) Y75B8A.14 Y75B8A.14 Member of the conserved hypothetical ATP binding protein family, has low similarity to a region of XPA binding protein 1 (human NTPBP), which is a cytoplasmic GTPase that binds the xeroderma pigmentosum group A protein (XPA) Y75B8A.17 Y75B8A.T;Y75B8A.17 Protein of unknown function Y75B8A.18 Y75B8A.U;Y75B8A.18 Protein of unknown function, has weak similarity to C. elegans Y75B8A.P Y75B8A.20 Y75B8A.W;Y75B8A.20 Protein of unknown function containing a Ground-like domain, has weak similarity to C. elegans F28A12.2 Y75B8A.21 Y75B8A.21 Protein with strong similarity to C. elegans F44G3.8 gene product This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins; this gene's encoded protein also contains an FTH/DUF38 motif, which may also mediate protein-protein interaction. Y75B8A.22 tim-1;Y75B8A.Y;Y75B8A.22 Protein with low similarity to timeless homolog (human TIMELESS), which is involved in circadian oscillation autoregulation Y75B8A.24 Y75B8A.24 Putative member of phosphoinositide 3-kinase family Phosphoinositide 3-kinase family, accessory domain (PIK domain) ; Phosphatidylinositol 3- and 4-kinases Y75B8A.25 Y75B8A.25 Protein with strong similarity to C. elegans Y17G9B.1 gene product Y75B8A.27 Y75B8A.27 Protein with moderate similarity to C. elegans Y75B8A.28 gene product The protein product of this gene is predicted to contain a glutamine/asparagine (Q/N)-rich ('prion') domain, by the algorithm of Michelitsch and Weissman (as of the WS77 release of WormBase, i.e., in wormpep77). Y75B8A.28 Y75B8A.28 Protein with moderate similarity to C. elegans Y75B8A.27 gene product Y75B8A.29 Y75B8A.29 Protein of unknown function Y75B8A.30 pph-4.1;Y75B8A.30 Protein of unknown function, putative ser/thr protein phosphatase Ser/Thr protein phosphatase Y75B8A.31 Y75B8A.31 Protein of unknown function Y75B8A.32 Y75B8A.32 Protein with weak similarity to C. elegans F53E10.5 gene product Y75B8A.33 Y75B8A.33 Protein of unknown function Y75B8A.34 Y75B8A.34 Putative ortholog of C. elegans C50E3.7 gene product Y75B8A.35 zip-1;Y75B8A.35 Protein with moderate similarity to C. elegans F37H8.2 gene product zip-1 encodes a protein with weak similarity to basic-leucine zipper-type transcription factors; ZIP-1 was identified in a screen for proteins able to bind a pharyngeal muscle-specific enhancer in the promoter of myo-2, which encodes a pharyngeal muscle-specific myosin; as loss of ZIP-1 activity via RNA-mediated interference (RNAi) does not result in any abnormalities, ZIP-1 may function redundantly in pharyngeal muscle specification; ZIP-1 is expressed strongly in the pharynx, but is also detected in hypodermal seam cells, vulval muscles, and posterior cells near the rectum. Y75B8A.36 Y75B8A.A;Y75B8A.36 Protein containing a protein kinase domain, has high similarity to a region of doublecortin and CaM kinase-like 1 (human DCAMKL1), which is a microtubule associated kinase that may regulate microtubule polymerization and central nervous system development Y75B8A.4 Y75B8A.E;Y75B8A.4 Member of the ATPase family associated with various cellular activities, contains an ATP-dependent serine protease (LON) domain, has a region of moderate similarity to a region of human PRSS15, which is a mitochondrial peptidase that binds DNA ATPases associated with various cellular activities (AAA) Y75B8A.6 Y75B8A.6 Putative ortholog of C. elegans Y75B8A.G gene product The protein product of this gene is predicted to contain a glutamine/asparagine (Q/N)-rich ('prion') domain, by the algorithm of Michelitsch and Weissman (as of the WS77 release of WormBase, i.e., in wormpep77). Y75B8A.9 Y75B8A.M;Y75B8A.9 Member of the glycosyl transferase family 2, contains two QXW (ricin B) lectin repeat domains, which may bind simple sugars, has moderate similarity to N-acetylgalactosaminyltransferase T1 (mouse Galnt1), which initiates O-glycosylation Glycosyl transferases Y75B8A.B php-3;Y75B8A.1;Y75B8A.B Homeodomain transcription factor with strong similarity to D. melanogaster ABD-B within the homeodomain, PHP-3 is required for posterior patterning in C. elegans Y75B8A.C nob-1;Y75B8A.2;Y75B8A.C Homeodomain transcription factor with strong similarity to D. melanogaster ABD-B over the homeodomain, NOB-1 is involved in posterior patterning in C. elegans Y75B8A.D Y75B8A.3;Y75B8A.D Member of the carboxylesterase type B family, has weak similarity to type T acetylcholinesterase (C. elegans ACE-1) Y75B8A.F Y75B8A.5;Y75B8A.F Protein containing two leucine rich repeats, which mediate protein-protein interactions Y75B8A.I Y75B8A.7;Y75B8A.I Protein with low similarity to M phase phosphoprotein 10 (human MPHOSPH10), which is a U3 small nucleolar ribonucleoprotein component that does not interact with small nucleolar RNAs except U3 and is phosphorylated and chromosome-associated in M phase Y75B8A.L Y75B8A.8;Y75B8A.L Protein of unknown function, has moderate similarity to C. elegans Y49G5B.B Y75B8A.O Y75B8A.11;Y75B8A.O Protein of unknown function Y75B8A.P Y75B8A.12;Y75B8A.P Protein of unknown function, has low similarity to uncharacterized human FLJ10715 Y75B8A.Q Y75B8A.13;Y75B8A.Q Protein of unknown function, has weak similarity to human microtubule-associated protein 1B (MAP1B/Hs.103042) Y75B8A.S Y75B8A.16;Y75B8A.S Protein of unknown function, has high similarity to uncharacterized C. elegans C11H1.2 Y75B8A.Z Y75B8A.23;Y75B8A.Z Protein of unknown function Y75D11A.1 Y75D11A.1 Protein with strong similarity to C. elegans ZC190.9 gene product Y75D11A.2 Y75D11A_91.B;Y75D11A.D;Y75D11A.2 Protein of unknown function, putative paralog of C. elegans Y75D11A_91.A Y75D11A.3 Y75D11A_91.A;Y75D11A.C;Y75D11A.3 Protein of unknown function, has very strong similarity to uncharacterized C. elegans Y75D11A_91.B Y75D11A.4 Y75D11A.4 Putative paralog of C. elegans Y76B12C.5 reverse transcriptase Y75D11A.5 Y75D11A.5 Putative paralog of C. elegans Y75D11A_90.A Y76A2A.1 Y76A2A.1 Protein of unknown function Y76A2A.2 cua-1;mnk;Y76A2A.2 Putative ortholog of S. cerevisiae CCC2 gene product [Copper-transporting P-type ATPase] Heavy-metal-associated domain containing proteins (2 domains), E1-E2 ATPases (2 domains); The cua-1 gene encodes a putative E1-E2 ATPase orthologous to the human gene KIAA1347 (ATP7A; OMIM:604384), which when mutated leads to Hailey-Hailey disease. Y76A2B.1 pod-1;Y76A2B.1 Member of the actin-binding coronin family that is necessary for anteroposterior axis specification in C. elegans WD domain, G-beta repeat (3 domains); The pod-1 gene encodes a coronin-like protein required for asymmetry along the anterior-posterior axis at the beginning of embryonic development. Y76A2B.2 Y76A2B.2 Protein with weak similarity to H. sapiens Hs.118893 (Human mRNA for KIAA0230 gene, partial cds) Leucine Rich Repeat (2 copies) (2 domains) Y76A2B.3 Y76A2B.3 Protein with high similarity to acyl-CoA synthetase 5 (rat Acs5), which catalyzes the synthesis of acyl-CoA from fatty acids, ATP, and CoA with a substrate preference for C16-C18 unsaturated fatty acids, member of the AMP-binding enzyme family AMP-binding enzyme Y76A2B.4 Y76A2B.4 Protein of unknown function Y76A2B.5 Y76A2B.5 Protein of unknown function Y76A2B.6 Y76A2B.6 Member of the CD36 family of putative scavenger receptors, has low similarity to CD36 antigen (human CD36), which is an integral membrane receptor that has roles in cell adhesion and transport CD36 family; Y76A2B.6 encodes a ortholog of human CD36 antigen (OMIM:173510, mutated in platelet glycoprotein IV deficiency); Y76A2B.6 is needed for cell corpse engulfment in the germline and in the three-fold embryo, and for migration of the anterior arm of the gonad. Y76B12C.1 Y76B12C.1 Putative paralog of C. elegans C23H5.7 Y76B12C.2 Y76B12C.2 Protein with strong similarity to H. sapiens XPC (xeroderma pigmentosum, complementation group C) Y76B12C.2 is orthologous to the human gene XERODERMA PIGMENTOSUM, COMPLEMENTATION GROUP C (XPC; OMIM:278720), which when mutated leads to disease. Y76B12C.3 Y76B12C.3 Protein with weak similarity to D. melanogaster CG7484 (CG7484 gene product) Y76B12C.4 Y76B12C.4 Putative paralog of C. elegans T03F1.9 Y76B12C.5 Y76B12C.5 Putative paralog of C. elegans Y75D11A.4 Y76B12C.6 Y76B12C.6 Protein of unknown function Y76B12C.7 Y76B12C.7 Putative ortholog of H. sapiens HSU37012 (Human cleavage and polyadenylation specificity factor mRNA, complete cds) Y76B12C.8 Y76B12C.8 Protein of unknown function Y76B12C_69.A Y76B12C.9;Y76B12C_69.A Protein with weak similarity to C. elegans K12D12.1 (Member of the topoisomerase II protein family) Y76G2A.1 C06A5.5;Y76G2A.1 Protein of unknown function, has moderate similarity to a region of C. elegans RSP-2, which is involved in mRNA splicing Y76G2A.A Y76G2A.2;Y76G2A.A Protein with strong similarity to C. elegans C06A5.10 gene product Y77E11A.1 Y77E11A.1 Putative paralog of C. elegans F14B4.2 (Member of the hexokinase protein family) Y77E11A.10 Y77E11A.10 Putative ortholog of D. melanogaster CalpB (Calpain-B) clp-6 encodes a calpain homolog that has significant identity to mammalian calpains over its whole length and that contains motifs typical of calpains, including a thiol (cysteine) protease active site and a Ca[2+]-binding domain; CLP-6 is not required for degenerative (necrotic-like) cell death in neurons induced by mutations such as mec-4(d), deg-3(d), or gsa-1(gf), since clp-6(RNAi) has no effect on such degeneration. Y77E11A.11 Y77E11A.11 Putative paralog of C. elegans tra-3 (Atypical calpain regulatory protease required in hermaphrodites for soma and germ line development) clp-7 encodes a member of the calpain family of cysteine proteases. Y77E11A.12 Y77E11A.12 Protein with strong similarity to C. elegans col-19 (Collagen, temporally regulated during the switch between the larval and adult developmental pathways) Y77E11A.13 Y77E11A.13 Putative ortholog of C. elegans Y77E11A_3670.C gene product Y77E11A.14 Y77E11A.14 Protein of unknown function Y77E11A.2 Y77E11A.2 Protein with strong similarity to C. elegans Y17G7B.10A Y77E11A.3 Y77E11A.3 Protein of unknown function Y77E11A.5 Y77E11A.5 Protein with weak similarity to C. elegans T23H4.2 (Member of the nuclear hormone receptor/Zinc finger protein family) Y77E11A.6 Y77E11A.6 Protein with moderate similarity to H. sapiens LOC51728 (RNA polymerase III subunit (hRPC11)) Y77E11A.7 Y77E11A.7 Protein of unknown function Y77E11A.8 Y77E11A.8 Protein of unknown function, putative paralog of C. elegans Y77E11A.9 Y77E11A.9 Y77E11A.9 Protein of unknown function, putative paralog of C. elegans Y77E11A.8 Y77E11A_3443.B jtr-1;cJTBR;Y77E11A.4;Y77E11A_3443.B Protein has weak similarity to Drosophila JTBR Y79H2A.1 Y79H2A.A;Y79H2A.1 Putative ortholog of C. elegans C51G7.4 gene product brp-1 encodes a glutamine-rich protein that is conserved in nematodes, but that has no known homologies or sequence motifs; BRP-1 is able to bypass the need for the S. cerevisiae mating pheromone MAP kinase cascade to activate the mating pheromone-responsive gene FUSl. Y79H2A.11 Y79H2A.G;Y79H2A.11 Protein containing a protein kinase domain, has a region of moderate similarity to a region of doublecortin and CaM kinase-like 1 (human DCAMKL1), which is a microtubule associated kinase that may regulate microtubule polymerization The zyg-8 gene encodes a protein with a doublecortin-like domain and a protein kinase domain; mutations of zyg-8 impair mitosis at the one-cell embryonic stage, which is normally asymmetrical, but which fails to show proper asymmetry in zyg-8 mutant embryos. Y79H2A.4 Y79H2A.D;Y79H2A.4 Protein with strong similarity to C. elegans F16B4.6 gene product Y79H2A.6 Y79H2A.6 Putative paralog of C. elegans Y79H2A.F (Putative ortholog of human Hs.90370/Sop2p-like protein, which may affect profilin function) Y79H2A.B Y79H2A.2;Y79H2A.B Protein with strong similarity to C. elegans C51G7.2 gene product Y79H2A.C Y79H2A.3;Y79H2A.E;Y79H2A.C Putative ortholog of C. elegans C51G7.3 gene product Y7A5A.1 Y7A5A.A;Y7A5A.1 Protein containing a FAD-binding domain, has moderate similarity to uncharacterized human DHCR24 Y7A5A.2 Y7A5A.B;Y7A5A.2 Protein of unknown function Y7A5A.3 Y75B8A.19;Y7A5A.D;Y7A5A.3 Protein of unknown function Y7A5A.4 Y7A5A.C;Y7A5A.4 Member of the transposase family, which are required for excising and inserting mobile genetic elements, has high similarity to uncharacterized C. elegans F56A4.8 Y7A5A.5 Y7A5A.E;Y7A5A.5 Protein of unknown function Y7A5A.6 Y7A5A.G;Y7A5A.6 Protein of unknown function Y7A5A.7 Y7A5A.H;Y7A5A.7 Protein of unknown function Y7A5A.8 Y7A5A.J;Y7A5A.8 Protein of unknown function Y7A5A.9 Y7A5A.K;Y7A5A.9 Protein of unknown function, has weak similarity to C. elegans K02H11.6 Y7A9A.1 Y7A9A.1 Member of the gamma-glutamyltranspeptidase family, which catalyze transfer of the gamma-glutamyl moiety of glutathione to an acceptor, has moderate similarity to gamma-glutamyl transferase (mouse Ggtp), which functions in cysteine homeostasis gamma-glutamyltranspeptidase Y7A9A.2 Y7A9A.2 Protein with weak similarity to C. elegans Y105C5B.3 gene product Y7A9C.1 Y7A9C.1 Protein containing a C3HC4 type (RING) zinc finger, which may mediate protein-protein interactions, has low similarity to uncharacterized C. elegans F42C5.4 Zinc finger, C3HC4 type (RING finger) Y7A9C.3 Y7A9C.3 Protein containing two DUF216 domains of unknown function, has weak similarity to uncharacterized C. elegans H12I19.1 Y7A9D.1 Y7A9D.1 Protein of unknown function Y80D3A.1 Y80D3A.1 Putative ortholog of S. cerevisiae WRS1 gene product (Tryptophanyl-tRNA synthetase) tryptophanyl-tRNA synthetase Y80D3A.10 Y80D3A.10 Protein of unknown function Y80D3A.2 Y80D3A.2 Putative ortholog of H. sapiens KIAA0560 (KIAA0560 gene product) Y80D3A.3 Y80D3A.3 Protein with weak similarity to C. elegans ceh-24 (Homeodomain transcription factor expressed in various nerve and muscle cells, mutant has no visible phenotype, has similarity over the homeodomain to many human and D. melanogaster homeodomain transcription factors) Y80D3A.4 Y80D3A.4 Putative paralog of C. elegans nhr-65 Y80D3A.8 Y80D3A.8 Putative paralog of C. elegans Y39B6B.E Y80D3A.9 Y80D3A.9 Putative paralog of C. elegans R186.1 Y81B9A.1 Y81B9A_23.C;Y81B9A.C;Y81B9A.1 Protein with strong similarity to C. elegans EGAP798.1 gene product Y81B9A.2 Y81B9A.2 Protein of unknown function, has strong similarity to C. elegans R09A8.1 Y81B9A.3 Y81B9A.3 Protein of unknown function Y81G3A.1 Y81G3A.1 Putative ortholog of C. elegans F42G4.6 gene product Y81G3A.3 Y81G3A.3 Protein of unknown function, has a putative protein kinase domain Eukaryotic protein kinase domain [2] Y81G3A.4 Y81G3A.4 Protein with weak similarity to C. elegans B0403.3 gene product Y81G3A.5 Y81G3A.5 Protein of unknown function, putative collagen collagen Y82E9BL.1 Y82E9BL.1 Protein with strong similarity to C. elegans Y82E9BL.a gene product Y82E9BL.12 Y82E9BL.12 Putative ortholog of C. elegans C31B8.12 gene product Y82E9BL.13 Y82E9BL.13 Putative ortholog of C. elegans Y82E9BL.k gene product Y82E9BL.14 Y82E9BL.14 Putative ortholog of C. elegans Y82E9BL.j gene product Y82E9BL.15 Y82E9BL.15 Putative ortholog of C. elegans Y82E9BL.m gene product Y82E9BL.16 Y82E9BL.16 Protein with strong similarity to C. elegans ZC47.6 gene product Y82E9BL.17 Y82E9BL.17 Putative ortholog of C. elegans Y82E9BL.n gene product Y82E9BL.4 Y82E9BL.4 Putative ortholog of C. elegans Y82E9BL.d gene product Y82E9BL.5 Y82E9BL.5 Putative ortholog of C. elegans Y82E9BL.d gene product Y82E9BL.6 Y82E9BL.6 Putative ortholog of C. elegans Y82E9BL.e gene product Y82E9BL.7 Y82E9BL.7 Putative ortholog of C. elegans Y82E9BL.e gene product Y82E9BL.8 Y82E9BL.8 Putative ortholog of C. elegans Y82E9BL.e gene product Y82E9BL.B Y82E9BL.2;Y82E9BL.B Putative ortholog of C. elegans Y82E9BL.3 gene product Y82E9BL.C Y82E9BL.3;Y82E9BL.C Putative ortholog of C. elegans Y82E9BL.6 gene product Y82E9BL.H Y82E9BL.10;Y82E9BL.H Putative ortholog of C. elegans Y82E9BL.11 gene product Y82E9BL.I Y82E9BL.11;Y82E9BL.I Putative ortholog of C. elegans Y82E9BL.10 gene product Y82E9BR.1 Y82E9BR.1 Putative ortholog of C. elegans Y82E9BR.17 gene product Y82E9BR.10 Y82E9BR.10 Protein of unknown function Y82E9BR.11 Y82E9BR.11 Protein of unknown function Y82E9BR.12 Y82E9BR.12 Protein with strong similarity to C. elegans T12B5.2 gene product Y82E9BR.13 Y82E9BR.13 Protein with strong similarity to C. elegans Y82E9BR.4 gene product Y82E9BR.14 Y82E9BR.14 Protein of unknown function Y82E9BR.15 Y82E9BR.15 Protein with strong similarity to C. elegans W03H1.2 gene product elc-1 encodes an ortholog of mammalian elongin C that appears to be required for proteolysis of germ plasm components (ZF1-containing proteins) in somatic cells, and for regulation of the cell cycle by CUL-2; elongin C forms a complex with (and positively regulates) elongin A, the active subunit of RNA polymerase II elongation factor SIII, and also binds to the von Hippel-Lindau (VHL) tumor suppressor; in yeast, elongin C also interacts with stress response proteins. Y82E9BR.16 Y82E9BR.16 Putative ortholog of C. elegans F45E10.2 gene product Y82E9BR.17 Y82E9BR.17 Putative ortholog of C. elegans Y82E9BR.1 gene product Y82E9BR.18 Y82E9BR.18 Protein of unknown function Y82E9BR.19 Y82E9BR.19 Protein of unknown function Y82E9BR.2 Y82E9BR.2 Protein with moderate similarity to C. elegans uaf-1 gene product Y82E9BR.3 Y82E9BR.3 Protein of unknown function Y82E9BR.4 Y82E9BR.4 Protein with strong similarity to C. elegans Y82E9BR.13 gene product Y82E9BR.5 Y82E9BR.5 Protein of unknown function Y82E9BR.6 Y82E9BR.6 Protein of unknown function Y82E9BR.7 Y82E9BR.7 Putative ortholog of C. elegans Y82E9BR.8 gene product Y82E9BR.8 Y82E9BR.8 Putative ortholog of C. elegans Y82E9BR.7 gene product Y82E9BR.9 Y82E9BR.9 Protein with strong similarity to C. elegans Y82E9BR.7 gene product Y87G2A.1 Y87G2A.1 Protein of unknown function Y87G2A.10 Y87G2A.10 Protein with strong similarity to D. melanogaster CG12770 (CG12770 gene product) Y87G2A.11 Y87G2A.11 Protein with strong similarity to H. sapiens TSSC1 (tumor suppressing subtransferable candidate 1) Y87G2A.12 Y87G2A.12 Protein of unknown function, putative paralog of C. elegans K01D12.2 Y87G2A.13 Y87G2A.13 Protein with weak similarity to D. melanogaster CG7638 (CG7638 gene product) Y87G2A.14 Y87G2A.14 Protein with weak similarity to D. melanogaster CG11095 (CG11095 gene product) The ndx-8 gene encodes a peroxisomal CoA diphosphatase with catalytic activity towards CoA and its derivatives, that is functionally homologous to the S. cerevisiae PCD1 enzyme; more generally, NDX-8 protein belongs to the family of NUDIX hydrolases. Y87G2A.2 Y87G2A.2 Protein with moderate similarity to C. elegans C37H5.13 Y87G2A.4 Y87G2A.4 Protein with strong similarity to C. elegans rab-3 (GTP-binding protein of the rab family (ras superfamily), putative ortholog of human RAB3A and RAB3B) Y87G2A.5 Y87G2A.5 Putative ortholog of S. cerevisiae VAS1 gene product (Valyl-tRNA synthetase (mitochondrial and cytoplasmic forms are coded from the same gene), member of class I family of aminoacyl-tRNA synthetases) vrs-2 encodes a predicted cytoplasmic valyl-tRNA synthetase (ValRS), a class I aminoacyl-tRNA synthetase that catalyzes the attachment of valine to its cognate tRNA and is thus required for protein biosynthesis; in C. elegans, VRS-2 activity is required for embryonic and germline development. Y87G2A.6 Y87G2A.6 Putative ortholog of H. sapiens KIAA0073 (Human mRNA for KIAA0073 gene, partial cds) cyclophilin; cyp-15 encodes a little-characterized cyclophilin homolog. Y87G2A.7 Y87G2A.7 Protein of unknown function, putative paralog of C. elegans T23G4.3 Y87G2A.8 Y87G2A.8 Putative ortholog of S. cerevisiae PGI1 gene product (Glucose-6-phosphate isomerase, converts glucose 6-phosphate to fructose 6-phosphate) glucose-6-phosphate isomerase; Y87G2A.8 is orthologous to the human gene GLUCOSE PHOSPHATE ISOMERASE (GPI; OMIM:172400), which when mutated leads to disease. Y87G2A.9 Y87G2A.9 Protein with strong similarity to S. cerevisiae UBC7 (Ubiquitin-conjugating enzyme) Y8A9A.1 Y8A9A.1 Putative ortholog of C. elegans ZK228.8 gene product Y8A9A.3 Y8A9A.E;Y8A9A.3 Protein with moderate similarity to C. elegans T24E12.1 gene product Y8A9A.4 Y8A9A.D;Y8A9A.4 Protein of unknown function Y8A9A.6 Y8A9A.A;Y8A9A.6 Protein of unknown function, has weak similarity to C. elegans ZK84.6 ins-32 encodes an insulin-like peptide of the insulin superfamily of proteins (OMIM:176730, 147440); INS-32 is one of 38 insulin-like peptides in C. elegans and the precise role of INS-32 in C. elegans development is not yet clear as loss of INS-32 function does not result in a mutant phenotype. Y8A9A.B Y8A9A.5;Y8A9A.B Protein containing an F-box domain, which serve as a link between a target protein and a ubiquitin-conjugating enzyme, has low similarity to uncharacterized C. elegans Y63D3A.3 Y8A9A.F Y8A9A.2;Y8A9A.F Protein of unknown function, has a region of weak similarity to a region of brain-specific angiogenesis inhibitor 1 (human BAI1), which is a putative cell adhesion molecule that may inhibit angiogenesis and tumor development inglioblastoma Y8G1A.1 Y8G1A.1 Protein containing a DUF236 domain of unknown function, has high similarity to uncharacterized C. elegans C04F12.6 Y8G1A.2 Y8G1A.2 Member of the integral membrane innexin family, which are involved in the formation of gap junctions, has moderate similarity to C. elegans UNC-9, which is required for normal locomotion membrane protein; probably a channel protein; inx-13 encodes an innexin, an integral transmembrane channel protein that is a structural component of invertebrate gap junctions; INX-13 is essential for larval development and osmoregulation, and may be a component of the gap junctions that link the excretory and hypodermal cells; INX-13 is expressed embryonically in hypodermis and post-embryonically, in hypodermal seam cells, the excretory cell, and the developing vulva and spermatheca; in hypodermal cells, INX-13 localizes to the plasma membrane at points of contact between adjacent cells. Y92C3A.3 cdh-12;Y71D11A.1;Y119D3B.L;Y92C3A.1;Y92C3A.2;Y92C3A.3 Putative cadherin Y92C3B.3 Y92C3B.3 Putative ortholog of C. elegans Y92C3B.A gene product rab-18 encodes a small GTPase homologous to the Rab GTPases that function in endocytosis, membrane fusion, and vesicular trafficking events; the precise biological role and expression pattern of rab-18 are not yet known. Y92C3B.B uaf-1;U2AF65;Y92C3B.2;Y92C3B.B Large subunit of splicing factor U2AF that recognizes U4CAG/R for splice site definition Y92C3B.C Y92C3B.1;Y92C3B.C Protein of unknown function, has weak similarity to C. elegans F23F12.8 Y92H12A.A Y92H12A.6;Y92H12A.A Protein of unknown function Y92H12A.B Y92H12A.5;Y92H12A.B Protein with strong similarity to C. elegans Y67D8A.E gene product Y92H12A.C Y92H12A.4;Y92H12A.C Putative ortholog of C. elegans Y51F10.4 gene product Y92H12A.D Y92H12A.3;Y92H12A.D Putative ortholog of C. elegans F26H9.3 gene product Y92H12A.E Y92H12A.2;Y92H12A.E Putative ortholog of C. elegans CeWwp1 gene product Y92H12A.G src-1;Y92H12A.1;Y92H12A.F;Y92H12A.G Tyrosine kinase that acts in parallel with Wnt signaling in C. elegans Y92H12BL.2 Y92H12BL.2 Protein of unknown function Y92H12BL.5 Y92H12BL.5 Protein with weak similarity to C. elegans T26E3.2 gene product The Y92H12BL.5 gene encodes a NUDIX hydrolase. Y92H12BL.A Y92H12BL.4;Y92H12BL.A Protein of unknown function Y92H12BL.D Y92H12BL.3;Y92H12BL.D Protein of unknown function Y92H12BM.A Y92H12BM.1;Y92H12BM.A Protein of unknown function Y92H12BR.3 Y92H12BR.3 Protein with strong similarity to C. elegans Y92H12BR.F gene product Y92H12BR.4 Y92H12BR.4 Protein with moderate similarity to C. elegans pha-1 gene product Y92H12BR.6 Y92H12BR.6 Putative ortholog of C. elegans Y92H12BR.5 gene product Y92H12BR.7 Y92H12BR.7 Putative ortholog of C. elegans M01B2.10 gene product Y92H12BR.8 Y92H12BR.8 Putative ortholog of C. elegans F37F2.1 gene product Y92H12BR.B Y92H12BR.2;Y92H12BR.B Protein of unknown function Y92H12BR.E Y92H12BR.5;Y92H12BR.E Putative ortholog of C. elegans Y92H12BR.6 gene product Y94A7B.1 Y94A7B.1 Member of the 7-transmembrane chemoreceptor family of G-protein coupled receptors (GPCR), has high similarity to uncharacterized C. elegans Y94A7B.3 Y94A7B.2 Y94A7B.2 TcA transposase Tc1 transposase Y94A7B.3 Y94A7B.3 Member of the 7-transmembrane chemoreceptor family of G-protein coupled receptors (GPCR), has high similarity to uncharacterized C. elegans Y94A7B.1 Y94A7B.4 Y94A7B.4 Member of the 7-transmembrane chemoreceptor family of G-protein coupled receptors (GPCR), has high similarity to uncharacterized C. elegans ZK1037.8 Y94A7B.5 Y94A7B.5 Member of the 7-transmembrane chemoreceptor family of G-protein coupled receptors (GPCR), has high similarity to uncharacterized C. elegans Y94A7B.6 Y94A7B.6 Y94A7B.6 Member of the 7-transmembrane chemoreceptor family of G-protein coupled receptors (GPCR), has high similarity to uncharacterized C. elegans Y94A7B.8 Y94A7B.7 Y94A7B.7 Putative ortholog of C. elegans Y94A7B.9 gene product Y94A7B.8 Y94A7B.8 Putative ortholog of C. elegans Y94A7B.6 gene product Y94A7B.9 Y94A7B.9 Putative ortholog of C. elegans Y94A7B.7 gene product Y94H6A.3 Y94H6A.3 Putative ortholog of C. elegans Y94H6A_149.C gene product Y94H6A.5 Y94H6A.5 Putative ortholog of C. elegans Y94H6A.F gene product Y94H6A.7 Y94H6A.7 Putative ortholog of C. elegans Y94H6A.D gene product Y94H6A.9 Y94H6A.9 Putative ortholog of C. elegans Y94H6A.B gene product Y94H6A.C Y94H6A.8;Y94H6A.C Protein with moderate similarity to D. melanogaster CG3214 (CG3214 gene product) Y94H6A.E Y94H6A.6;Y94H6A_131.B;Y94H6A.E Protein with high similarity to ubiquitin-conjugating enzyme E2H (human UBE2H), which covalently adds ubiquitin moieties to proteins and may be involved in histone ubiquitinoylation, member of the ubiquitin-conjugating enzyme (E2) family Y94H6A.G Y94H6A.4;Y94H6A_149.B;Y94H6A.G Member of the glutathione peroxidase family, which catalyze reduction of hydroxyperoxides by glutathione, has low similarity to glutathione peroxidase 1 (rat Gpx1), which detoxifies peroxide in the oxidative stress response Y94H6A.H Y94H6A_149.C;Y94H6A.H Putative ortholog of C. elegans Y94H6A.3 gene product Y94H6A.I Y94H6A.2;Y94H6A.I Protein of unknown function, has strong similarity to C. elegans W04G5.8 Y94H6A.J Y94H6A.1;Y94H6A_142.A;Y94H6A.J Protein containing nuclear hormone receptor ligand-binding and C4-type zinc finger domains, has a region of low similarity to a region of retinoic acid receptor gamma (human RARG), which is a ligand-dependent nuclear receptor Y94H6A_1.B Y54G2A.10;Y94H6A_1.B Protein of unknown function, has high similarity to uncharacterized C. elegans Y54G2A.32 Y94H6A_136.C lin-22;Y94H6A_127.A;Y94H6A_136.C Basic helix-loop-helix (bHLH) protein involved in cell lineage identification and male tail development Y95B8A.1 Y95B8A.1 Putative paralog of C. elegans K04E7.3 peptidase Y95B8A.10 Y95B8A.10 Putative ortholog of H. sapiens PDE8B (phosphodiesterase 8B) phosphodiesterase Y95B8A.11 Y95B8A.11 Protein of unknown function Y95B8A.12 Y95B8A.12 Protein with weak similarity to S. cerevisiae CDC24 (GTP-GDP exchange factor for Cdc42p, involved in bud emergence, bud site selection and formation of mating projection (shmoo)) nucleotide exchange factor Y95B8A.2 Y95B8A.2 Protein of unknown function, has weak similarity to C. elegans T04F8.8 Y95B8A.3 Y95B8A.3 Putative paralog of C. elegans Y73F8A.29 transposase Y95B8A.4 Y95B8A.4 Protein of unknown function Y95B8A.5 gpa-16;Y95B8A.5 Alpha subunit of heterotrimeric G protein G-protein; gpa-16 (also known as spn-1) encodes a member of the G protein alpha subunit family of heterotrimeric GTPases that affects spindle position and orientation in embryos; it is expressed in AVM, PDE, PLM, BDU, PVC, and RIP, and weakly expressed in the pharynx, body-wall muscle, and vulval muscle. Y95B8A.6 Y95B8A.6 Protein of unknown function, has weak similarity to C. elegans F39D8.3 Y95B8A.7 Y95B8A.7 Protein with strong similarity to H. sapiens KIAA1086 (KIAA1086 protein) zinc finger protein Y95B8A.8 Y95B8A.8 Protein of unknown function Y95B8A.9 Y95B8A.9 Protein with moderate similarity to C. elegans ptl-1 (Tau-repeat protein that promotes microtubule assembly) Y97E10AL.1 Y97E10AL.1 Putative ortholog of C. elegans Y97E10AL.C gene product Y97E10AL.2 Y97E10AL.2 Putative ortholog of C. elegans Y97E10AL.B gene product Y97E10AL.3 Y97E10AL.3 Putative ortholog of C. elegans Y97E10AL.A gene product Y97E10AM.A Y97E10AM.1;Y97E10AM.A Protein of unknown function Y97E10AR.1 Y97E10AR.1 Putative ortholog of C. elegans Y97E10AR.F gene product Y97E10AR.2 Y97E10AR.2 Putative ortholog of C. elegans Y97E10AR.E gene product Y97E10AR.3 Y97E10AR.3 Protein with weak similarity to C. elegans Y97E10AR.C gene product Y97E10AR.4 Y97E10AR.4 Putative ortholog of C. elegans Y97E10AR.C gene product Y97E10AR.5 Y97E10AR.5 Putative ortholog of C. elegans Y97E10AR.A gene product Y97E10AR.6 Y97E10AR.6 Putative ortholog of C. elegans Y97E10AR.A gene product Y97E10AR.7 Y97E10AR.7 Protein with strong similarity to C. elegans Y97E10AR.B gene product Y97E10B.1 Y97E10B.1 Putative ortholog of C. elegans C33H5.2 gene product Y97E10B.10 Y97E10B.10 Putative ortholog of C. elegans Y97E10B.A gene product 7TM chemoreceptor, srt family Y97E10B.2 Y97E10B.2 Putative ortholog of C. elegans Y97E10B.F gene product 7TM chemoreceptor, srsx family Y97E10B.3 Y97E10B.3 Putative ortholog of C. elegans Y97E10B.F gene product 7TM chemoreceptor, srsx family Y97E10B.4 Y97E10B.4 Putative ortholog of C. elegans Y97E10B.F gene product 7TM chemoreceptor, srsx family Y97E10B.6 Y97E10B.6 Protein with strong similarity to C. elegans R10D12.4 gene product Y97E10B.7 Y97E10B.7 Putative ortholog of C. elegans C07A9.11 gene product Y97E10B.8 Y97E10B.8 Protein with strong similarity to C. elegans F40D4.5 gene product Y97E10B.9 Y97E10B.9 Putative ortholog of C. elegans Y97E10B.A gene product 7TM chemoreceptor, srsx family Y9C12A.1 Y9C12A.1 Protein with weak similarity to H. sapiens Hs.73182 Y9C2UA.1 Y9C2UA.1 Protein of unknown function Y9C2UA.2 Y9C2UA.2 Protein of unknown function Y9C9A.1 Y9C9A.1 Protein of unknown function, putative paralog of C. elegans Y40B10B.B Y9C9A.10 Y9C9A.10 Protein of unknown function, putative paralog of C. elegans Y45G12C.12 7TM chemoreceptor, str family Y9C9A.11 Y9C9A.11 Protein of unknown function, putative paralog of C. elegans Y9C9A.10 7TM chemoreceptor, str family Y9C9A.12 Y9C9A.12 Protein of unknown function, has moderate similarity to C. elegans F44G3.8 Y9C9A.13 Y9C9A.13 Protein of unknown function, has strong similarity to C. elegans C33A12.12 Y9C9A.14 Y9C9A.14 Protein of unknown function, has moderate similarity to C. elegans C08F11.9 Y9C9A.15 Y9C9A.15 Protein of unknown function, has strong similarity to C. elegans C08F11.9 7TM chemoreceptor, srz family Y9C9A.16 Y9C9A.16 Putative paralog of C. elegans F02H6.5 Y9C9A.17 Y9C9A.17 Protein of unknown function, putative paralog of C. elegans Y9C9A.9 Y9C9A.18 Y9C9A.18 Protein of unknown function, has strong similarity to C. elegans T08B6.3 7TM chemoreceptor, str family Y9C9A.2 Y9C9A.2 Protein of unknown function, putative paralog of C. elegans Y9C9A.3 7TM chemoreceptor, str family Y9C9A.3 Y9C9A.3 Protein of unknown function, putative paralog of C. elegans Y9C9A.2 7TM chemoreceptor, str family Y9C9A.4 Y9C9A.4 Protein of unknown function, putative paralog of C. elegans Y9C9A.6 7TM chemoreceptor, str family Y9C9A.5 Y9C9A.5 Protein of unknown function, putative paralog of C. elegans Y9C9A.4 Y9C9A.6 Y9C9A.6 Protein of unknown function, putative paralog of C. elegans Y9C9A.4 7TM chemoreceptor, str family Y9C9A.7 Y9C9A.7 Protein of unknown function, has strong similarity to C. elegans T08B6.6 7TM chemoreceptor, str family Y9C9A.8 Y9C9A.8 Protein of unknown function, has strong similarity to C. elegans F47H4.6 Y9C9A.9 Y9C9A.9 Protein of unknown function, putative paralog of C. elegans Y9C9A.17 7TM chemoreceptor, str family Y9D1A.1 Y9D1A.C;Y9D1A.1 Protein with strong similarity to C. elegans Y9D1A.A gene product Y9D1A.2 Y9D1A.A;Y9D1A.2 Protein of unknown function, has moderate similarity to uncharacterized C. elegans Y46H3C.5 ZC101.1 ZC101.1 Protein containing seven low-density lipoprotein (LDL) receptor class A domains, has a region of low similarity to a region of glycoprotein 330 (megalin, rat Lrp2), which plays a role in transcytosis of thyroglobulin into the bloodstream low-density lipoprotein receptor; The protein product of this gene is predicted to contain a glutamine/asparagine (Q/N)-rich ('prion') domain, by the algorithm of Michelitsch and Weissman (as of the WS77 release of WormBase, i.e., in wormpep77). ZC101.2 unc-52;ZC101.2 Perlecan, a muscle protein, member of the Immunoglobulin superfamily UNC-52 membrane proteoglycan; The unc-52 gene encodes perlecan, a protein orthologous to human basement membrane-specific heparan sulfate proteoglycan core protein (HSPG2; OMIM:142461, which when mutated leads to Schwartz-Jampel syndrome or dyssegmental dysplasia); UNC-52 plays essential roles in muscle structure development and regulation of growth factor-like signaling pathways; UNC-52 is synthesized by the hypodermis and localizes to the extracellular matrix between hypodermis and muscle. ZC116.1 ZC116.1 Protein of unknown function ZC116.2 ZC116.2 Protein with high similarity to somatic cytochrome c (rat Cycs), which is involved in non-apoptotic cell death and the oxidative stress response, contains a cytochrome c family heme-binding site domain cytochrome c; This gene encodes a protein predicted by Eisenberg and coworkers, with 52% accuracy, to be mitochondrial. ZC116.3 ZC116.3 Protein containing thirteen CUB domains, which occur in developmentally regulated proteins and seven epidermal growth factor-like domains, has weak similarity to cubilin (rat Cubn), which is involved in receptor mediated endocytosis; bone morphogenetic protein 1 like; ZC116.3 is orthologous to the human gene CUBILIN (CUBN; OMIM:602997), which when mutated leads to hereditary megaloblastic anaemia 1 (OMIM:261100). ZC123.1 ZC123.1 Protein of unknown function, has weak similarity to C. elegans K08E7.5 ZC123.3 ZC123.3 Protein containing ten C2H2 type zinc finger domains, which bind nucleic acids, and three homeobox domains (homeodomain), which are found in transcription factors, has weak similarity to a region of AT-binding transcription factor 1 (mouse Atbf1) zinc finger protein ZC123.4 ZC123.4 Protein with high similarity to cyclin-dependent protein kinase 2 (human CDK2), which interacts with cyclins and regulates kinase activity, cell cycle progression and DNA replication, contains a protein kinase domain protein kinase ZC13.1 ZC13.1 Protein containing a C-terminal C3HC4-type (RING) zinc finger domain zinc finger protein ZC13.2 ZC13.2 Protein of unknown function ZC13.3 ZC13.3 Protein containing a MAM domain, which are extracellular domains found in many receptors ZC13.4 ZC13.4 Protein with moderate similarity to C. elegans F21A3.3 mab-7 encodes a protein with a hydrophobic type II transmembrane region at the N-terminus, an EGF-like motif, a ShKT motif and a long C-terminus; mab-7 is involved in morphogenesis of the mail tail, specifically affecting the structural cells, neuronal processes and the hypodermal sheath of the sensory rays, as such, it affects mating in males; a mab-7 promoter-gfp construct is expressed in hypodermis, body seam, ray structural cells, and several neurons in the head and tail region. ZC132.1 ZC132.1 Member of the transposase family, which are required for excising and inserting mobile genetic elements, has very strong similarity to uncharacterized C. elegans F11D11.9 transposase ZC132.2 ZC132.2 Protein with strong similarity to C. elegans T02B11.4 gene product ZC132.3 ZC132.3 Protein containing a DUF216 domain of unknown function ZC132.4 ZC132.4 Protein with strong similarity to C. elegans Y75D11A.5 gene product ZC132.5 ZC132.5 Protein containing a retroviral integrase core domain, which are the central catalytic domains that can act as endonucleases ZC132.6 ZC132.6 Protein with strong similarity to C. elegans F49D11.4 gene product ZC132.7 ZC132.7 Putative ortholog of C. elegans F47D2.9 gene product 7TM chemoreceptor, srh family ZC132.8 ZC132.8 Protein with moderate similarity to C. elegans ZC132.9 gene product ZC132.9 ZC132.9 Protein with strong similarity to C. elegans ZK218.4 gene product ZC142.1 ZC142.1 Protein containing a DUF32 domain of unknown function, has high similarity to uncharacterized C. elegans ZC142.2 7TM chemoreceptor, srt family ZC142.2 ZC142.2 Protein containing a DUF32 domain of unknown function, has high similarity to uncharacterized C. elegans ZC142.1 7TM chemoreceptor, srt family ZC15.1 ZC15.1 Protein of unknown function, has low similarity to uncharacterized C. elegans ZK228.1 ZC15.2 ZC15.2 Putative ortholog of C. elegans Y113G7C.A gene product ZC15.3 ZC15.3 Putative ortholog of C. elegans F41G4.6 gene product ZC15.5 ZC15.5 Protein of unknown function ZC15.6 ZC15.6 Protein containing a C-type lectin domain, which mediate calcium-dependent carbohydrate recognition, has high similarity to uncharacterized C. elegans F21H7.4 ZC15.7 ZC15.7 Protein containing 11 ankyrin (Ank) repeats, has low similarity to a region of inversin (mouse Invs), which determines left-right asymmetry during embryogenesis and may play a role in hepatobiliary and cardiac morphogenesis Ank repeat (6 domains) ZC15.8 ZC15.8 Protein of unknown function The protein product of this gene is predicted to contain a glutamine/asparagine (Q/N)-rich ('prion') domain, by the algorithm of Michelitsch and Weissman (as of the WS77 release of WormBase, i.e., in wormpep77). ZC155.1 nex-1;ZC155.1 Annexin expressed in the pharynx, uterine wall, vulva, and spermathecal valves nex-1 encodes an annexin, a member of a family of calcium-dependent phospholipid binding proteins; NEX-1 is required for efficient engulfment of apoptotic cell corpses in the pharynx, and may also function in other membrane fusion events, such as exocytosis; NEX-1 in vitro can bind phosphatidylserine, phosphatidylinositol, heparin, heparan sulfate, and chondroitin sulfate; NEX-1 is expressed in the pharynx, hypodermal cells, the vulva, the uterus, the spermathecal valve, and yolk granules of maturing oocytes. ZC155.2 ZC155.2 Protein of unknown function ZC155.3 ZC155.3 Protein of unknown function, has a region of low similarity to a region of microrchidia (mouse Morc), which is a male germ cell-specific protein involved in spermatogenesis and germ cell apoptosis ZC155.4 ZC155.4 Member of the glycerophosphoryl diester phosphodiesterase family, which are involved in lipid metabolism, has a region of low similarity to membrane interacting protein of RGS16 (rat Mir16), which associates with Rgs16 and Rgs2 ZC155.5 ZC155.5 Protein of unknown function, predicted to contain a glycosylphosphatidylinositol (GPI) lipid anchor ZC155.7 ZC155.7 Putative syntaxin ZC168.1 ZC168.1 Member of the sodium or calcium exchanger protein family of membrane transporters, which regulate intracellular Ca2+ concentrations, has low similarity to sodium-calcium exchanger 3 (rat Ncx3), which is a sodium-calcium antiporter sodium/calcium exchanger protein like; ncx-3 encodes a predicted transmembrane Na/Ca exchanger; by homology, NCX-3 is predicted to function as a plasma membrane protein that regulates intracellular calcium homeostasis by moving calcium either into or out of cells, depending upon the net electrochemical force; however, as loss of ncx-3 function via RNA-mediated interference (RNAi) does not result in any obvious abnormalities, the precise role of NCX-3 in C. elegans development and/or behavior is not yet known. ZC168.2 ZC168.2 Protein of unknown function ZC168.3 ZC168.3 Protein with weak similarity to origin recognition complex subunit 5-like (human ORC5L), which is part of a core origin recognition complex that may function in DNA replication initiation or in the origin recognition complex ZC168.4 ZC168.4 Protein containing cyclin N-terminal and C-terminal domains, which often form complexes with protein kinases and cyclin dependent protein kinases (CDI), has low similarity to cyclin B1 (rat Ccnb1), which helps to mediate G2-M phase transition cyclin; cyb-1 encodes a cyclin B homolog that appears to be required both for embryogenesis (via maternally encoded CYB-1) and for postembryonic development and fertility (via zygotically encoded CYB-1); removing maternal product in cyb-1(RNAi) embryos causes multiple nuclei, and affected embryos arrest development at an early embryonic stage. ZC168.5 ZC168.5 Protein of unknown function containing a Ground-like domain, has weak similarity to C. elegans T24A6.15 ZC168.6 ZC168.6 Protein containing a major sperm protein (MSP) domain, which are involved in sperm motility, has strong similarity to uncharacterized C. elegans F55C5.1 ZC178.1 ZC178.1 Protein of unknown function, has weak similarity to C. elegans C50C3.2 ZC178.2 ZC178.2 Protein with low similarity to S. cerevisiae Muc1p, which is a cell surface flocculin required for invasive and pseudohyphal growth ZC190.1 cln-3.3;ZC190.1 Member of the CLN3 protein family, which are involved in Batten disease, has moderate similarity to ceroid-lipofuscinosis neuronal 3 (human CLN3), which is a protein involved in lysosomal pH homeostasis that is associated with Batten disease intergral membrane protein ZC190.10 ZC190.10 Protein of unknown function, has weak similarity to C. elegans B0511.2 ZC190.2 ZC190.2 Protein of unknown function, has weak similarity to C. elegans T03F7.5 ZC190.4 ZC190.4 Protein containing a SAM (sterile alpha motif) domain, which may mediate protein-protein interactions ZC190.5 ZC190.5 Protein with moderate similarity to C. elegans ZC190.6 gene product ZC190.6 ZC190.6 Protein with moderate similarity to C. elegans ZC190.5 gene product ZC190.7 ZC190.7 Protein of unknown function ZC190.8 ZC190.8 Protein of unknown function ZC190.9 ZC190.9 Protein of unknown function, has very strong similarity to uncharacterized C. elegans Y75D11A.1 ZC196.1 ZC196.1 Putative ortholog of C. elegans B0507.6 gene product ZC196.2 ZC196.2 Protein containing a major sperm protein (MSP) domain, which are involved in sperm motility, has low similarity to uncharacterized C. elegans F42G2.5 ZC196.3 ZC196.3 Protein with strong similarity to C. elegans B0507.4 gene product ZC196.4 ZC196.4 Protein with moderate similarity to C. elegans ZC196.3 gene product ZC196.5 ZC196.5 Protein with strong similarity to C. elegans Y2H9A.4 gene product ZC196.6 ZC196.6 Protein with weak similarity to S. cerevisiae PTK2 (Serine/threonine protein kinase required for high-affinity polyamine transport) ZC196.7 glr-5;ZC196.7 Protein containing a ligand-gated ion channel domain, has low similarity to glutamate receptor ionotropic kainate-selective 2 (human GRIK2), which is a ligand-gated ion channel subunit that plays a role in excitatory neurotransmission ligand-gated ionic channel protein; glr-5 encodes a kainate (non-NMDA)-type ionotropic glutamate receptor subunit; GLR-5 activity is required for normal brood sizes, especially at high temperatures; GLR-5 is expressed in neurons. ZC196.8 ZC196.8 Protein of unknown function, has high similarity to uncharacterized C. elegans F58F6.6 ZC196.9 ZC196.9 Protein of unknown function, has very strong similarity to uncharacterized C. elegans F58F6.6 ZC204.1 ZC204.1 Protein containing a DUF148 domain of unknown function, has high similarity to uncharacterized C. elegans ZK488.7 ZC204.10 ZC204.10 Protein containing an F-box domain, which serve as a link between a target protein and a ubiquitin-conjugating enzyme, has high similarity to uncharacterized C. elegans ZC204.7 This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins; its encoded protein also contains a Pfam-B45 motif of presently unknown function. ZC204.11 ZC204.11 Protein containing a BTB (BR-C, ttk and babor) or POZ (Pox virus and zinc finger) domain, which are found in some DNA and actin binding proteins and may mediate protein-protein interactions, has moderate similarity to uncharacterized C. elegans F47C10.2 ZC204.12 ZC204.12 Protein with strong similarity to C. elegans ZC204.13 gene product ZC204.13 ZC204.13 Protein with strong similarity to C. elegans ZC204.12 gene product ZC204.14 ZC204.14 Protein of unknown function, has moderate similarity to uncharacterized C. elegans W06A11.4 ZC204.15 ZC204.15 Protein of unknown function, has high similarity to uncharacterized C. elegans K04F1.3 7TM chemoreceptor, srw family ZC204.2 ZC204.2 Homeodomain transcription factor, has weak similarity to human DUX1 homeodomain transcription factor homeobox protein ZC204.3 ZC204.3 Protein containing a BTB (BR-C, ttk and babor) or POZ (Pox virus and zinc finger) domain, which are found in some DNA and actin binding proteins and may mediate protein-protein interactions, has low similarity to uncharacterized C. elegans F57C2.1 ZC204.4 ZC204.4 Member of the C. elegans Srg family of integral membrane proteins, which may be involved in chemosensation, has high similarity to uncharacterized C. elegans Y105C5A.11 7TM chemoreceptor, srg family ZC204.5 ZC204.5 Member of the 7-transmembrane chemoreceptor family of G-protein coupled receptors (GPCR), has high similarity to uncharacterized C. elegans T10D4.5 7TM chemoreceptor, srh family ZC204.6 ZC204.6 Protein with moderate similarity to C. elegans ZC204.8 gene product ZC204.7 ZC204.7 Protein containing an F-box domain, which serve as a link between a target protein and a ubiquitin-conjugating enzyme, has high similarity to uncharacterized C. elegans ZC204.10 ZC204.8 ZC204.8 Protein containing two F-box domains, which serve as a link between a target protein and a ubiquitin-conjugating enzyme, has low similarity to uncharacterized C. elegans W08F4.2 This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins; its encoded protein also contains a Pfam-B45 motif of presently unknown function. ZC204.9 ZC204.9 Protein containing an F-box domain, which serve as a link between a target protein and a ubiquitin-conjugating enzyme, has moderate similarity to uncharacterized C. elegans Y56A3A.15 This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins; its encoded protein also contains a Pfam-B45 motif of presently unknown function. ZC21.2 ZC21.2 Member of the ank repeat protein family Transient-receptor-potential (trp) protein ZC21.3 ZC21.3 Protein of unknown function Dual bar protein; The protein product of this gene is predicted to contain a glutamine/asparagine (Q/N)-rich ('prion') domain, by the algorithm of Michelitsch and Weissman (as of the WS77 release of WormBase, i.e., in wormpep77). ZC21.4 gap-2;CEGAP;C04D8.1;ZC21.4 GTPase-activating protein that acts on multiple Ras subfamilies ZC21.6 ZC21.6 Protein of unknown function ZC21.8 ZC21.8 Protein of unknown function, has weak similarity to C. elegans C10G11.1 ZC239.10 ZC239.10 Member of the 7-transmembrane chemoreceptor family of G-protein coupled receptors (GPCR), has high similarity to uncharacterized C. elegans ZC239.8 7TM chemoreceptor, sri family ZC239.12 ZC239.12 Protein containing a K+ channel tetramerization domain, which facilitate assembly of alpha-subunits into functional tetrameric channels, has strong similarity to uncharacterized C. elegans F22E5.6 ZC239.13 ZC239.13 Protein containing a K+ channel tetramerization domain, which facilitate assembly of alpha-subunits into functional tetrameric channels ZC239.14 ZC239.14 Protein containing a K+ channel tetramerization domain, which facilitate assembly of alpha-subunits into functional tetrameric channels, has high similarity to uncharacterized C. elegans ZC239.4 ZC239.15 ZC239.15 Protein containing a K+ channel tetramerization domain, which facilitate assembly of alpha-subunits into functional tetrameric channels, has high similarity to uncharacterized C. elegans F22E5.8 ZC239.16 ZC239.16 Protein containing a K+ channel tetramerization domain, which facilitate assembly of alpha-subunits into functional tetrameric channels, has high similarity to uncharacterized C. elegans ZC239.17, which is a putative potassium voltage-gated channel ZC239.17 ZC239.17 Protein containing a K+ channel tetramerization domain, which facilitate assembly of alpha-subunits into functional tetrameric channels, has high similarity to uncharacterized C. elegans ZC239.16 ZC239.19 ZC239.19 Putative ortholog of C. elegans F22E5.14 gene product 7TM chemoreceptor, sri family ZC239.2 ZC239.2 Protein containing a K+ channel tetramerization domain, which facilitate assembly of alpha-subunits into functional tetrameric channels, has low similarity to uncharacterized C. elegans K02F6.8 ZC239.3 ZC239.3 Protein containing a K+ channel tetramerization domain, which facilitate assembly of alpha-subunits into functional tetrameric channels, has low similarity to a region of human LOC51133, which is the NY-REN-45 tumor antigen ZC239.4 ZC239.4 Protein containing a K+ channel tetramerization domain, which facilitate assembly of alpha-subunits into functional tetrameric channels, has high similarity to uncharacterized C. elegans ZC239.14, which is a putative potassium voltage-gated channel ZC239.5 ZC239.5 Protein containing a K+ channel tetramerization domain, which facilitate assembly of alpha-subunits into functional tetrameric channels, has low similarity to uncharacterized C. elegans K02F6.8 ZC239.6 ZC239.6 Protein containing a K+ channel tetramerization domain, which facilitate assembly of alpha-subunits into functional tetrameric channels, has moderate similarity to uncharacterized C. elegans K02F6.8 ZC239.7 gcy-15;ZC239.7 Putative guanylyl cyclase guanylate cyclase ZC239.8 ZC239.8 Member of the 7-transmembrane chemoreceptor family of G-protein coupled receptors (GPCR), has high similarity to uncharacterized C. elegans ZC239.10 7TM chemoreceptor, sri family ZC239.9 ZC239.9 Member of the 7-transmembrane chemoreceptor family of G-protein coupled receptors (GPCR), has high similarity to uncharacterized C. elegans F22E5.4 7TM chemoreceptor, sri family ZC247.1 ZC247.1 Putative ortholog of C. elegans Y106G6F.A gene product ZC247.2 ZC247.2 Protein of unknown function ZC247.3 lin-11;ZC247.3 LIM homeodomain transcription factor involved in the differentiation but not the initiation of specific neurons and in the asymmetric division of vulval blast cells; has strong similarity to human and Drosophila LIM domain transcription factors LIM domain containing proteins (2 domains), homeobox protein (lim subfamily); lin-11 encodes a predicted LIM homeodomain transcription factor that affects vulval development, neuronal development and fate specification, utse cell differentiation, and fertility; it is expressed in some neurons, the vulva, pi cells and their progeny, and the spermatheca. ZC247.4 ZC247.4 Member of the Tc3 Transposase protein family transposase ZC250.1 ZC250.1 Protein with weak similarity to C. elegans cyp-2 (Cyclophilin-related peptidylprolyl cis-trans-isomerase) ZC250.2 ZC250.2 Protein with weak similarity to H. sapiens LFNG (lunatic fringe (Drosophila) homolog) ZC250.3 ZC250.3 Putative nucleotide-sugar transporter, has strong similarity to human CMP-sialic acid transporter (Hs.82921) and human UDP-galactose translocator (Hs.21899) ZC262.1 ZC262.1 Protein of unknown function, has very strong similarity to uncharacterized C. elegans R05D3.5 ZC262.2 ZC262.2 Protein of unknown function ZC262.3 ZC262.3 Protein containing four leucine rich repeats, which mediate protein-protein interactions, and two immunoglobulin (Ig) domains, which may be involved in protein-protein and protein-ligand interactions N-CAM IG domain ZC262.4 ZC262.4 Protein of unknown function ZC262.5 ZC262.5 Protein of unknown function, has very strong similarity to uncharacterized C. elegans R05D3.6 ATPase epsilon chain ZC262.8 ZC262.8 Protein of unknown function ZC266.1 ZC266.1 Protein of unknown function ZC266.2 ZC266.2 Protein of unknown function ZC302.1 mre-11;ZC302.1 Putative ortholog of S. cerevisiae Mre11p, a single-stranded endonuclease and double-stranded exonuclease required for double strand break repair and meiotic recombination Human MRE11 protein like; mre-11 encodes a protein orthologous to S. cerevisiae MRE11 and to human MRE11A (OMIM:600814, mutated in ataxia-telangiectasia-like disorder); MRE-11 is required for meiotic recombination and DNA repair in C. elegans, for multigenerational persistence of the germline, and (in conjunction with CHK-2 and SPO-11) for the localization of RAD-51 to foci in late zygotene/early pachytene nuclei. ZC302.2 ZC302.2 Protein containing seven WD domains (WD-40 repeat), which may mediate protein-protein interactions, has low similarity to S. pombe Tup11p, which is a transcriptional repressor functioning redundantly with Tup12p guanine nucleotide binding protein ZC302.3 ZC302.3 Protein of unknown function ZC308.1 ZC308.1 Protein of unknown function, has a region of low similarity to a region of DNA polymerase kappa (S. pombe Cid1p), which is involved in caffeine sensitivity gld-2 encodes the catalytic subunit of a cytoplasmic poly(A) polymerase (PAP) associated with P granules in early embryos, which encodes the central catalytic domain but lacks the normal RNA-binding (RRM) domain of eukaryotic PAPs; GLD-2 regulates the switch from mitosis to meiosis in the germline, is necessary for formation of functional sperm or oocytes, requires activation by GLD-3 for PAP activity in vitro, and contains a glutamine/asparagine-rich domain perhaps involved in epigenetic gene control. ZC308.2 ZC308.2 Protein of unknown function ZC308.3 ZC308.3 Protein of unknown function ZC308.4 ZC308.4 Protein of unknown function ZC317.1 ZC317.1 Member of the DEAD or DEAH box ATP-dependent RNA helicase family and contains a helicase conserved C-terminal domain, has low similarity to C. elegans CGH-1, which is required for gametogenesis and prevention of germline apoptosis helicase ZC317.2 ZC317.2 Protein of unknown function ZC317.3 glc-3;ZC317.3 L-Glutamate-gated chloride channel subunit ligand-gated ionic channel subunit; The glc-3 gene encodes a fipronil and BIDN-sensitive, but picrotoxinin-insensitive, L-glutamate-gated chloride channel subunit. ZC317.4 ZC317.4 Protein of unknown function, has high similarity to uncharacterized C. elegans ZC317.5 7TM chemoreceptor, srg family ZC317.5 ZC317.5 Protein of unknown function, has high similarity to uncharacterized C. elegans ZC317.4 7TM chemoreceptor, srg family ZC317.6 ZC317.6 Protein of unknown function, has very strong similarity to uncharacterized C. elegans C14C11.1 ZC317.7 ZC317.7 Protein of unknown function, has very strong similarity to uncharacterized C. elegans C14C11.2 ZC328.1 ZC328.1 Protein of unknown function ZC328.2 ZC328.2 Protein containing five C2H2 type zinc finger domains, has a region of low similarity to a region of zinc finger protein subfamily 1A 4 (Eos, mouse Znfn1a4), which is a putative transcription factor that may play a role in neurogenesis zinc finger protein ZC328.3 ZC328.3 Protein containing a GRAM domain, which are found in glucosyltransferases, myotubularins and other putative membrane-associated proteins ZC328.4 ZC328.4 Protein with weak similarity to S. cerevisiae MAD3 (Spindle-assembly checkpoint protein required for cell cycle delay in response to impaired kinetochore function) ZC328.5 ZC328.5 Protein of unknown function ZC334.1 ZC334.1 Protein of unknown function, has weak similarity to C. elegans ZC334.2 ZC334.2 ZC334.2 Protein of unknown function, has high similarity to uncharacterized C. elegans ZC334.3 ZC334.3 ZC334.3 Protein of unknown function, has high similarity to uncharacterized C. elegans ZC334.2 ins-24 encodes an insulin-like peptide of the insulin superfamily of proteins (OMIM:176730, 147440); INS-24 is one of 38 insulin-like peptides in C. elegans, but as loss of INS-24 function via RNA-mediated interference does not result in any abnormalities, the precise role of INS-24 in C. elegans development is not yet clear. ZC334.4 ZC334.4 TcA transposase Tc1 transposase ZC334.5 ZC334.5 Protein of unknown function, has high similarity to uncharacterized C. elegans F47G4.2 ZC373.1 ZC373.1 Member of the pyridoxal phosphate dependent enzyme beta family, has a region of high similarity to a region of cystathionine beta-synthase (L-serine hydrolyase, rat Cbs), which catalyzes condensation of serine and homocysteine to generate cystathionine cystathionine beta-synthase; The ZC373.1 gene encodes an ortholog of the human gene CYSTATHIONINE-BETA-SYNTHASE (CBS), which when mutated leads to homocystinuria (OMIM:236200). ZC373.2 ZC373.2 Protein of unknown function, has weak similarity to C. elegans Y37D8A.19 ZC373.3 ZC373.3 Protein containing a protein kinase domain, has a region of low similarity to a region of casein kinase 1 delta (rat Csnk1d), which is a serine/threonine protein kinase possibly involved in DNA repair serine/threonine kinase ZC373.4 ZC373.4 Protein containing a protein kinase domain, has a region of moderate similarity to a region of myosin light polypeptide kinase (human MYLK), which is a calcium/calmodulin-dependent kinase that acts on regulatory myosin light chains to activate contraction calcium/calmodulin dependent protein kinase ZC373.5 ZC373.5 Protein containing a Class II aldolase domain, has moderate similarity to uncharacterized mouse Mmrp19 ZC373.6 dao-4;ZC373.6 Protein of unknown function; regulated by dauer pathway proteins ZC373.7 ZC373.7 Protein containing two collagen triple helix repeats, which are found in some extracellular proteins, and a nematode cuticle collagen N-terminal domain, has moderate similarity to a region of C. elegans BLI-1 cuticular collagen ZC374.1 ZC374.1 Member of the rhodopsin family of G-protein coupled receptors (GPCR) hormone receptor ZC374.2 ZC374.2 Protein containing three fibronectin type III domains, which are involved in cell surface binding Fibronectin type III domain (4 domains) ZC376.1 ZC376.1 Member of the carboxylesterase type B family, has weak similarity to butyrylcholinesterase (human BCHE), which is implicated in fluoride resistance, acholinesterasemia, and apnea upon gene mutation and the K variant is associated with Alzheimer's disease carboxylesterase ZC376.2 ZC376.2 Member of the carboxylesterase type B family, has low similarity to intestinal and liver carboxylesterase 2 (human CES2), which catalyzes the hydrolysis of the benzoyl group of cocaine and the acetyl group of heroin carboxylesterase ZC376.3 ZC376.3 Member of the carboxylesterase type B family, has low similarity to carboxylesterase 2 (human CES2), which catalyzes the hydrolysis of the benzoyl group of cocaine and the acetyl group of heroin and may be involved in their degradation carboxylesterase ZC376.4 ZC376.4 Protein of unknown function, has weak similarity to C. elegans K04C1.2 Homeobox domain ZC376.5 trm-1;ZC376.5;Trm1 Member of the N2,N2-dimethylguanosine tRNA methyltransferase family, has low similarity to N2,N2-dimethylguanine tRNA methyltransferase (S. cerevisiae Trm1p), which is required for methylation of G26 of both mitochondrial and cytoplasmic tRNAs N2,N2-dimethylguanosine tRNA methyltransferase ZC376.6 ZC376.6 Protein of unknown function ZC376.7 ZC376.7 Protein of unknown function DNA binding domain ZC376.8 ZC376.8 Protein containing a DUF236 domain of unknown function, has strong similarity to uncharacterized C. elegans F47B3.4 ZC395.1 ZC395.1 Protein of unknown function ZC395.10 ZC395.10 Protein with low similarity to S. pombe Wos2p, which regulates Wee1p and Cdc2p in the cell cycle ZC395.11 ZC395.11 Protein with moderate similarity to C. elegans T11F9.7 gene product ZC395.2 clk-1;ZC395.2 Required for ubiquinone (coenzyme Q, or Q) synthesis; also affects various biological timing processes The clk-1 gene partially controls lifespan in vivo; it encodes a homolog of the yeast COQ9 protein, and is necessary for the biosynthesis of ubiquinone (UQ(9)) from demethoxyubiquinone (DMQ(9)). ZC395.3 toc-1;ZC395.3 Member of the cation efflux family, which may be membrane divalent cation transporters toc-1 encodes an integral membrane protein with similarity to divalent metal ion transporters; by homology, TOC-1 is predicted to function in regulation of intracellular metal ion (particularly zinc) homeostasis; toc-1 is the upstream gene in an operon with clk-1, a timing gene that is necessary for ubiquinone biosynthesis; RNAi experiments directed against toc-1 sequences result in egg-laying defects, abnormal body coloration, retarded postembryonic growth rates, and generally sick animals. ZC395.4 ZC395.4 Protein of unknown function ZC395.5 ZC395.5 Protein of unknown function ZC395.6 gro-1;ZC395.6 Strongly similar to tRNA isopentenyltransferase; mitochondrial protein that appears to be involved in control of the rate of development and life-span tRNA isopentenyltransferase; This gene encodes a protein predicted by Eisenberg and coworkers, with 52% accuracy, to be mitochondrial. ZC395.7 hap-1;ZC395.7 Protein with high similarity to inosine triphosphatase (human ITPA), which is involved in ITP degradation, member of the HAM1 family, which may be involved in sensing base analogs such as 6-N-hydroxylaminopurine ZC395.8 ZC395.8 Protein containing two C2H2 type zinc finger domains, which bind nucleic acids ZC404.1 ZC404.1 Protein of unknown function ZC404.10 ZC404.10 Protein of unknown function, has high similarity to uncharacterized C. elegans ZC404.13 ZC404.11 ZC404.11 Member of the rhodopsin family of G-protein coupled receptors (GPCR), has high similarity to uncharacterized C. elegans ZC404.13 ZC404.12 ZC404.12 Putative ortholog of C. elegans ZC404.5 gene product 7TM chemoreceptor, srh family ZC404.13 ZC404.13 Putative ortholog of C. elegans T15B7.12 gene product ZC404.2 ZC404.2 Protein of unknown function ZC404.3 ZC404.3 Protein of unknown function ZC404.5 ZC404.5 Member of the 7-transmembrane chemoreceptor family of G-protein coupled receptors (GPCR), has low similarity to uncharacterized C. elegans ZC404.12 7TM chemoreceptor, srh family ZC404.7 ZC404.7 Protein of unknown function ZC404.8 spn-4;ZC404.8 Putative RNA-binding protein, has similarity over the N-terminus to C. elegans FOX-1 RNA-binding protein; spn-4 encodes a protein containing an RNP-type RNA-binding domain; SPN-4 is required for rotation, but not polarization, of the mitotic spindle in the P1 blastomere of the two-cell stage embryo; SPN-4 is also required for mesectoderm and mesendoderm formation in conjunction with proper localization of maternal cell-fate determinants such as SKN-1; in addition, SPN-4 binds the glp-1 3' UTR and is necessary for glp-1 mRNA translation in the anterior blastomeres of the early embryo; conversely, SPN-4 binds and suppresses translation of pal-1 and skn-1 mRNAs in anterior blastomeres; in vitro, SPN-4 interacts with POS-1, a CCCH-type zinc finger protein that negatively regulates glp-1 mRNA translation in posterior blastomeres; SPN-4 is a P granule component, but is also detected in oocytes, the AB and P1 blastomeres at the two-cell stage, and in all four blastomeres at the four-cell stage, with higher levels in EMS and P2. ZC404.9 ZC404.9 Protein containing a protein kinase domain and a regulatory citron homology domain, has moderate similarity to mitogen-activated protein kinase kinase kinase kinase 5 (human MAP4K5), which is a protein kinase that activates Jun N-terminal kinase serine/threonine kinase ZC410.1 nhr-11;ZC410.1 Member of the zinc finger, C4 type protein family nuclear hormone receptor ZC410.2 ZC410.2 Protein with high similarity to mitochondrial processing peptidase beta subunit (rat Pmpcb), which is a metalloendopeptidase that cleaves the N-termini of nuclearly-encoded mitochondrial precursors, member of the insulinase (peptidase M16) family mitochondrial processing peptidase; This gene encodes a protein predicted by Eisenberg and coworkers, with 52% accuracy, to be mitochondrial. ZC410.3 ZC410.3 Member of the glycosyl hydrolase 47 family of alpha-mannosidases, which hydrolyze terminal mannose residues, has moderate similarity to alpha-mannosidase (S. cerevisiae Mns1p), which removes one mannose from Man9GlcNac to produce Man8GlcNac Man(9)-alpha-mannosidase ZC410.4 twk-19;ZC410.4 Member of the 4 TM potassium channel protein family potassium channel protein like; twk-8 encodes one of more than 40 TWK (two-P domain K+) potassium channels in C. elegans that contain two pore regions and four transmembrane domains; expressed in body-wall muscle. ZC410.5 ZC410.5 Protein of unknown function microfilarial antigen like ZC410.7 Ny;ZC410.7 Member of the biotin or lipoate A-B protein ligase family, which catalyze biotin or lipoic acid attachment to enzymes, has a region of low similarity to a region of S. cerevisiae Lip2p The lpl-1 gene encodes a lipoate ligase homolog; this gene resides in an operon that also contains the genes icl-1 and C01F6.9. ZC411.1 ZC411.1 Protein of unknown function, has very strong similarity to uncharacterized C. elegans F07B7.7 ZC412.1 ZC412.1 Member of the rhodopsin family of G-protein coupled receptors (GPCR), has weak similarity to neurokinin A receptor (rat Tacr2), which is a substance K receptor G-protein coupled receptor ZC412.2 gcy-14;ZC412.2 Putative guanylyl cyclase guanylate cyclase; gcy-14 encodes a predicted transmembrane guanylyl cyclase; the precise role of GCY-14 in C. elegans development and/or behavior is not yet known; however, by sequence similarity GCY-14 can be predicted to function in chemosensory signal transduction. ZC412.3 ZC412.3 Protein of unknown function, has moderate similarity to uncharacterized C. elegans ZC412.4 ZC412.4 ZC412.4 Protein of unknown function, has moderate similarity to uncharacterized C. elegans ZC412.3 ZC412.5 ZC412.5 Protein of unknown function, has high similarity to uncharacterized C. elegans ZK512.8 ZC412.6 ZC412.6 Protein of unknown function, has weak similarity to C. elegans ZC412.7 ZC412.7 ZC412.7 Protein of unknown function, has very strong similarity to uncharacterized C. elegans H12D21.1 ZC412.8 ZC412.8 Protein of unknown function, has weak similarity to C. elegans H12D21.3 ZC412.9 ZC412.9 Protein with strong similarity to C. elegans H12D21.2 gene product ZC416.1 ZC416.1 Protein with moderate similarity to C. elegans H20J04.3 gene product ZC416.2 ZC416.2 Protein of unknown function ZC416.4 ZC416.4 Protein with high similarity to mitogen-activated protein kinase 10 (human MAPK10), which phosphorylates c-Jun (JUN) in response to cellular stressors such as ultraviolet light and osmotic stress, contains a protein kinase domain protein kinase ZC416.6 ZC416.6 Protein with high similarity to C. elegans AP-1, which is an arginine aminopeptidase, member of the M1 peptidase family of aminopeptidases protease ZC416.8 cha-1;ZC416.8 Choline acetyltransferase putative acetylcholine transporter; unc-17 encodes a synaptic vesicle acetylcholine transporter (VAChT) highly conserved amongst metazoans including Drosophila and humans (OMIM:600336); UNC-17 is essential for embryonic development, and is required in cholinergic neurons for loading acetylcholine into synaptic vesicles to which UNC-17 is localized; UNC-17 expression may be regulated indirectly by the UNC-4/UNC-37 transcriptional repressor complex, as UNC-17 expression is greatly reduced in unc-4 and unc-37 mutant backgrounds. ZC434.2 rps-7;ZC434.2 Member of the ribosomal protein S7 protein family 40S ribosomal protein S7; rps-7 encodes a small ribosomal subunit S7 protein. ZC434.3 ZC434.3 Protein with strong similarity to C. elegans F35D2.2 gene product ZC434.4 ZC434.4 Protein of unknown function ZC434.5 ZC434.5 Putative glutamyl-prolyl-tRNA synthetase glutamyl-trna synthetase; ers-2 encodes a predicted mitochondrial glutamyl-tRNA synthetase (GluRS), a class I aminoacyl-tRNA synthetase that catalyzes the attachment of glutamate to its cognate tRNA and is thus required for protein biosynthesis; ERS-2 contains, at its C-terminus, six tandemly repeated WHEP-TRS domains that have been predicted to function as general RNA-binding domains that may act as cis tRNA-binding cofactors. ZC434.6 aph-2;ZC434.6 Protein required for GLP-1-mediated interactions between cells P2 and ABp; necessary for the development of pharyngeal cells aph-2 encodes an ortholog of nicastrin, which associates with presenilin and membrane-bound Notchl in aph-2 mutants, the specification of pi-cells is compromised. ZC434.7 ZC434.7 Protein of unknown function ZC434.8 ZC434.8 Protein containing a plant ATP-guanido phosphotransferase N-terminal domain and an ATP:guanido phosphotransferase C-terminal catalytic domain, has moderate similarity to creatine kinase (muscle form, mouse Ckmm), which is important for energy homeostasis arginine kinase ZC434.9 ZC434.9 Putative carboxypeptidase carboxypeptidase ZC443.1 ZC443.1 Member of the aldo/keto reductase protein family, has moderate similarity to aldose reductase (rat Akr1b1), which reduces glucose and other carbonyl-containing substrates as part of the polyol pathway and metabolizes xenobiotics aldose reductase ZC443.2 ZC443.2 Protein of unknown function ZC443.3 ZC443.3 Protein of unknown function, has low similarity to uncharacterized C. elegans ZC443.4 ZC443.4 ZC443.4 Protein of unknown function, has low similarity to uncharacterized C. elegans ZC443.3 ZC443.5 ZC443.5 Protein containing a UDP-glucoronosyl and UDP-glucosyl transferase domain, has low similarity to bilirubin UDP-glucuronosyltransferase (rat UDPGT), which conjugates lipophilic aglycon substrates with glucuronic acid UDP-glucuronosyltransferase ZC443.6 ZC443.6 Protein containing a UDP-glucoronosyl and UDP-glucosyl transferase domain, has low similarity to UDP glycosyltransferase 2 family polypeptide B7 (human UGT2B7), which glucuronidates androgens, retinoids, lipids, and specific drugs UDP-glucuronosyltransferase ZC449.1 ZC449.1 Protein containing three PAN domains, which may mediate protein-protein or protein-carbohydrate interactions ZC449.2 ZC449.2 Protein containing two PAN domains, which may mediate protein-protein or protein-carbohydrate interactions ZC449.3 ZC449.3 Protein containing a protein kinase domain, has moderate similarity to mitogen-activated protein kinase kinase 4 (mouse Map2k4), which may be involved in the response to cellular stress and may trigger apoptosis map kinase kinase; 3beta-hsd ZC449.4 ZC449.4 Protein of unknown function ZC449.5 ZC449.5 Protein of unknown function, has weak similarity to uncharacterized trans-golgi network protein 2 (human TGOLN2) ZC449.6 ZC449.6 Putative ortholog of C. elegans ZC8.1 gene product ZC455.1 ZC455.1 Protein of unknown function ZC455.10 dao-9;ZC455.10 Member of the FK506-binding protein protein family FK506-binding protein like; fkb-4 encodes a peptidylprolyl cis/trans isomerase homologous to mammalian FK506 immunosuppressant-binding protein 9; FKB-4 expression is positively regulated by signaling through the DAF-2 insulin receptor-like pathway and in part, through the activity of the DAF-16 fork-head transcription factor suggesting that FKB-4 could play a role in metabolism and longevity; as loss of FKB-4 function via RNA-mediated interference does not result in any abnormalities, the precise role of FKB-4 in C. elegans development and/or behavior is not yet known; FKB-4 contains a predicted endoplasmic reticulum (ER) retention sequence and is thus proposed to localize to the ER. ZC455.11 ZC455.11 Protein containing two DUF40 domains of unknown function, which contain four conserved cysteines, has low similarity to uncharacterized C. elegans C02A12.5 7TM receptor, srbc family ZC455.3 ZC455.3 Protein containing a UDP-glucoronosyl and UDP-glucosyl transferase domain, which transfer glycosyl groups to small hydrophobic molecules, has low similarity to UDP-glucuronosyltransferase 2B family member 5 (mouse Ugt2b5) UDP-glucuronysltransferase ZC455.4 ZC455.4 Member of the UDP-glucuronosyltransferase protein family, has high similarity to uncharacterized C. elegans ZC455.6 UDP-glucuronysltransferase ZC455.5 ZC455.5 Protein containing two UDP-glucoronosyl and UDP-glucosyl transferase domains, which transfer glycosyl groups to small hydrophobic molecules, has low similarity to rat Ugt1a7, which is a UDP-glucuronosyltransferase UDP-glucuronysltransferase ZC455.6 ZC455.6 Protein containing a UDP-glucoronosyl and UDP-glucosyl transferase domain, which transfer glycosyl groups to small hydrophobic molecules, has low similarity to rat Ugt1a7, which is a UDP-glucuronosyltransferase UDP-glucuronysltransferase ZC455.7 ZC455.7 Member of the C. elegans Sre G protein-coupled chemoreceptor family, which are putative chemosensory receptors, has low similarity to uncharacterized C. elegans F36D1.2 7TM receptor, sre family ZC455.8 ZC455.8 Protein containing a DUF40 domain of unknown function, which contain four conserved cysteines, has high similarity to uncharacterized C. elegans ZC455.9 7TM receptor, srbc family ZC455.9 ZC455.9 Protein containing a DUF40 domain of unknown function, which contain four conserved cysteines, has high similarity to uncharacterized C. elegans ZC455.8 7TM receptor, srbc family ZC47.10 ZC47.10 Protein containing two DUF38 domains of unknown function, and an F-box domain, which serve as a link between a target protein and a ubiquitin-conjugating enzyme, has high similarity to uncharacterized C. elegans Y119D3A.3 ZC47.12 ZC47.12 Protein containing an F-box domain, which serve as a link between a target protein and a ubiquitin-conjugating enzyme, and a DUF38 domain of unknown function, has weak similarity to C. elegans FOG-2, which is required for the sexual identity of germ cells This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins; this gene's encoded protein also contains an FTH/DUF38 motif, which may also mediate protein-protein interaction. ZC47.13 ZC47.13 Protein containing an F-box domain, which serve as a link between a target protein and a ubiquitin-conjugating enzyme, and a DUF38 domain of unknown function, has low similarity to C. elegans FOG-2, which is required for the sexual identity of germ cells This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins; this gene's encoded protein also contains an FTH/DUF38 motif, which may also mediate protein-protein interaction. ZC47.14 ZC47.14 Protein containing an F-box domain, which serve as a link between a target protein and a ubiquitin-conjugating enzyme, and a DUF38 domain of unknown function, has low similarity to C. elegans FOG-2, which is required for the sexual identity of germ cells This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins; this gene's encoded protein also contains an FTH/DUF38 motif, which may also mediate protein-protein interaction. ZC47.3 ZC47.3 Protein containing two F-box domains, which serve as a link between a target protein and a ubiquitin-conjugating enzyme, and two DUF38 domains of unknown function, has low similarity to C. elegans FOG-2, which is required for germ cell sexual identity This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins; this gene's encoded protein also contains an FTH/DUF38 motif, which may also mediate protein-protein interaction. ZC47.4 ZC47.4 Protein containing an F-box domain, which serve as a link between a target protein and a ubiquitin-conjugating enzyme, and a DUF38 domain of unknown function, has low similarity to C. elegans FOG-2, which is required for the sexual identity of germ cells This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins; this gene's encoded protein also contains an FTH/DUF38 motif, which may also mediate protein-protein interaction. ZC47.5 ZC47.5 Protein containing an F-box domain, which serve as a link between a target protein and a ubiquitin-conjugating enzyme, and a DUF38 domain of unknown function, has low similarity to C. elegans FOG-2, which is required for the sexual identity of germ cells This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins; this gene's encoded protein also contains an FTH/DUF38 motif, which may also mediate protein-protein interaction. ZC47.6 ZC47.6 Protein containing an F-box domain, which serve as a link between a target protein and a ubiquitin-conjugating enzyme, and a DUF38 domain of unknown function, has low similarity to C. elegans FOG-2, which is required for the sexual identity of germ cells This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins; this gene's encoded protein also contains an FTH/DUF38 motif, which may also mediate protein-protein interaction. ZC47.9 ZC47.9 Protein containing an F-box domain, which serve as a link between a target protein and a ubiquitin-conjugating enzyme, and a DUF38 domain of unknown function, has weak similarity to C. elegans FOG-2, which is required for the sexual identity of germ cells This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins; this gene's encoded protein also contains an FTH/DUF38 motif, which may also mediate protein-protein interaction. ZC477.1 ZC477.1 Protein of unknown function, has a region of moderate similarity to a region of S. cerevisiae Hkr1p, which is a hansenula mrakii K9 killer toxin-resistance protein ZC477.10 ZC477.10 Protein with strong similarity to C. elegans F42G8.8 gene product ZC477.2 ZC477.2 Member of the serine/threonine protein phosphatase protein family serine/ threonine specific protein phosphatase ZC477.3 ZC477.3 Serine/threonine protein phosphatase serine/threonine specific phosphatase ZC477.4 ZC477.4 Protein of unknown function ZC477.5 ZC477.5 Protein of unknown function ZC477.7 ZC477.7 Protein of unknown function, has very strong similarity to uncharacterized C. elegans T28H11.7 ZC477.9 deb-1;ZC477.9 Vinculin of muscle dense bodies, has strong similarity to chicken vinculin The deb-1 gene encodes a vinculin ortholog highly conserved amongst metazoans including Drosophila, chick, and humans (OMIM:193065); DEB-1 is a muscle attachment protein found in dense bodies, and is required for attaching actin thin filaments to the basal sarcolemma; DEB-1 requires PAT-4/integrin-linked kinase for full assembly into nascent attachments. | The deb-1 gene encodes a vinculin ortholog highly conserved amongst metazoans including Drosophila, chick, and humans (OMIM:193065); DEB-1 is a muscle attachment protein found in dense bodies and M lines and is required for attaching actin and myosin filaments to the basal sarcolemma; DEB-1 requires PAT-4/integrin-linked kinase for full assembly into nascent attachments. ZC482.1 ZC482.1 Protein containing neurotransmitter-gated ion-channel transmembrane and ligand binding domains, has moderate similarity to mouse Gabrb3, which is the beta 3 subunit of the gamma-amino butyric acid A receptor and is associated with cleft palate GABA receptor; gab-1 encodes a gamma-aminobutyric acid (GABA) receptor beta-like subunit with both the neurotransmitter-gated ion-channel ligand binding and transmembrane domains; gab-1 can form a GABA-responsive channel when co-expressed with alpha/gamma type subunits in a heterologous expression system; experiments with gab-1 indicate that GABA receptors are involved in the mechanism of resistance to the widely used broad-spectrum anthelmintic drug Ivermectin. ZC482.2 ZC482.2 Protein containing a DUF41 domain of unknown function, has high similarity to uncharacterized C. elegans ZC482.3 ZC482.3 ZC482.3 Protein containing a DUF41 domain of unknown function, has high similarity to uncharacterized C. elegans ZC482.2 ZC482.4 ZC482.4 Protein containing a DUF41 domain of unknown function, has moderate similarity to uncharacterized C. elegans ZC482.2 ZC482.5 ZC482.5 Protein containing neurotransmitter-gated ion-channel transmembrane and ligand binding domains, has moderate similarity to GABA-A receptor gamma 2 subunit (human GABRG2), which is a chloride channel and inhibitory neurotransmitter associated with epilepsy GABA receptor; ZC482.5 is orthologous to the human gene GAMMA-AMINOBUTYRIC ACID A RECEPTOR GAMMA 2 (GABRG2; OMIM:137164), which when mutated leads to disease. ZC482.6 ZC482.6 Protein of unknown function, has moderate similarity to uncharacterized C. elegans H10D18.3 7TM chemoreceptor, srw family ZC482.7 ZC482.7 Protein containing a DUF41 domain of unknown function, has moderate similarity to uncharacterized C. elegans F59D6.4 ZC487.1 ZC487.1 Protein of unknown function ZC487.2 ZC487.2 Protein of unknown function ZC487.3 ZC487.3 Protein of unknown function ZC487.4 ZC487.4 Protein with moderate similarity to C. elegans Y47D7A.J gene product ZC487.5 ZC487.5 Protein with moderate similarity to C. elegans ZC487.4 gene product ZC504.1 ZC504.1 Protein containing one kunitz or bovine pancreatic trypsin inhibitor domain ZC504.2 acr-8;ZC504.2 Protein containing neurotransmitter-gated ion-channel ligand binding and transmembrane domains, has moderate similarity to C. elegans UNC-38, which is a nicotinic acetylcholine receptor alpha subunit acetylcholine receptor protein; acr-8 encodes an alpha subunit of nicotinic acetylcholine receptor (nAChR); ACR-8 falls into the 'ACR-8' class of nAChR subunits, which includes ACR-12 and ACR-13. ZC504.3 ZC504.3 Protein containing a protein kinase domain, has moderate similarity to cell division cycle 2 like 2 (mouse Cdc2l2), which is a protein kinase that binds Src-homology 2 (SH2) domains and may be involved in cell proliferation during embryonic development serine/threonine kinase (CDC2/CDKX subfamily) ZC504.4 mig-15;ZC504.4 Protein with high similarity to mitogen-activated protein kinase kinase kinase kinase 4 (human MAP4K4), which is a serine-threonine kinase, contains three protein kinase domains and three regulatory citron homology domains serine/threonine kinase (PAK/STE20 subfamily); The mig-15 gene encodes a Nck-interacting kinase (NIK) that is required to inhibit premature branching of commissures. ZC504.5 gur-3;ZC504.5 Member of the seven-transmembrane receptor odorant receptor family, which function in olfaction, has moderate similarity to uncharacterized C. elegans GUR-2 gur-3 encodes a predicted seven-transmembrane protein related to the gustatory class of receptors in Drosophila. ZC506.1 ZC506.1 Member of the glycosyl hydrolase 47 family of alpha-mannosidases, which hydrolyze terminal mannose residues, has low similarity to mannosidase 1 alpha (mannosyl-oligosaccharide alpha-1-2-mannosidase or ER mannosidase I, mouse Man1a) man(9)-alpha-mannosidase ZC506.2 ZC506.2 Protein of unknown function ZC506.3 ZC506.3 Protein with high similarity to phosphatidylserine synthase 1 (mouse Ptdss1), which catalyzes a base-exchange reaction between the polar head group of phospholipids, member of the phosphatidyl serine synthase family phosphatidylserine synthase I ZC506.4 mgl-1;ZC506.4 Member of the metabotrobic glutamate family of G-protein coupled receptors (GPCR) containing a receptor family ligand binding domain, has moderate similarity to metabotropic glutamate receptor type 3 (human GRM3), which is a neurotransmitter receptor metatrophic glutamate receptor; mgl-1 encodes a Group II metabotropic glutamate receptor (OMIM:604099, loss-of-function mutations in mice are associated with defects in long-term depression); by homology, MGL-1 is predicted to function as a pre-synaptic G protein-coupled receptor that, in response to glutamate binding, inhibits adenylyl cyclase activity; loss of mgl-1 activity via large-scale RNAi screens indicates that, in C. elegans, MGL-1 is required for normal post-embryonic growth rates; an mgl-1::GFP reporter is expressed in interneurons, motor neurons, and pharyngeal neurons. ZC513.1 ZC513.1 Protein containing a lipopolysaccharide-binding protein, bactericidal permeability-increasing protein, or cholesteryl ester transfer protein C-terminal domain ZC513.10 ZC513.10 Protein containing a DUF38 domain of unknown function and an F-box domain, which serve as a link between a target protein and a ubiquitin-conjugating enzyme, has moderate similarity to uncharacterized C. elegans C06H5.1 This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins; this gene's encoded protein also contains an FTH/DUF38 motif, which may also mediate protein-protein interaction. ZC513.11 ZC513.11 Member of the 7-transmembrane chemoreceptor family of G-protein coupled receptors (GPCR), has low similarity to C. elegans ODR-10, which is a G protein-coupled receptor involved in the odorant response 7TM chemoreceptor, str family ZC513.2 ZC513.2 Protein of unknown function, has weak similarity to C. elegans C55C3.1 ZC513.3 ZC513.3 Protein of unknown function ZC513.4 ZC513.4 Member of the class I isoleucyl, leucyl, valyl, and methionyl (I, L, M, and V) tRNA synthetase family, has weak similarity to cytoplasmic isoleucyl-tRNA synthetase (S. cerevisiae Ils1p) valyl-tRNA synthetase ZC513.5 ZC513.5 Protein with low similarity to S. cerevisiae Ecm39p, which is a mannosyltransferase involved in the dolichol pathway for N-glycosylation ZC513.6 dao-7;ZC513.6 Protein containing two CCCH-type zinc finger domains, has a region of moderate similarity to a region of C. elegans MEX-1, which is a highly conserved germline protein among eukaryotes and is required for differentiation of some cell lineages zinc finger protein; The oma-2 gene encodes a zinc finger protein of the TIS11 finger type that is paralogous to OMA-1; while either oma-1 or oma-2 individually have no obvious mutant phenotype, a normal copy of at least one of these genes is required for oocyte maturation. ZC513.7 ZC513.7 Protein of unknown function ZC513.8 col-43;ZC513.8 Protein with strong similarity to C. elegans SQT-3, which is a collagen that is involved in cuticle synthesis and morphogenesis of the epithelium, contains two collagen triple helix repeats and one nematode cuticle collagen N-terminal domain cuticualr collagen; col-43 encodes a collagen that is individually dispensable for viability and gross morphology in mass RNAi screens. ZC513.9 ZC513.9 Member of the 7-transmembrane chemoreceptor family of G-protein coupled receptors (GPCR), has weak similarity to C. elegans ODR-10, which is a G protein-coupled receptor involved in odorant response 7TM chemoreceptor, str family ZC518.1 ZC518.1 Member of the C. elegans putative membrane protein family 8, has moderate similarity to a region of bestrophin (human VMD2), which plays a role in vision and is associated with several macular pathologies Putative membrane protein ZC518.2 ZC518.2 Member of the COPII coat protein, Sec24p-like protein family Yeast YIK9 like ZC518.3 ZC518.3 Protein containing six leucine rich repeats, which mediate protein-protein interactions, has low similarity to a region of S. cerevisiae Ccr4p, which is a component of both the CCR4 transcriptional complex and the major cytoplasmic mRNA deadenylase alcohol dehydrogenase transcription effector like ZC518.4 ZC518.4 Protein of unknown function ZC53.1 ZC53.1 Protein of unknown function ZC53.2 ZC53.2 Protein of unknown function, has weak similarity to C. elegans C52E2.A ZC53.3 ZC53.3 Member of the transposase family, which are required for excising and inserting mobile genetic elements, has high similarity to uncharacterized C. elegans Y73B3A.19 transposase ZC53.4 ZC53.4 Protein containing a retroviral integrase core domain, which are the central catalytic domains that can act as endonucleases ZC53.6 ZC53.6 Protein with strong similarity to C. elegans F54F7.7 gene product ZC53.7 rgs-9;ZC53.7 Protein containing two regulator of G protein signaling domains, has a region of low similarity to regulator of G protein signaling 1 (mouse Rgs1), which is involved in B lymphocyte migration and chemotaxis inhibition ZC581.1 ZC581.1 Protein containing a protein kinase domain, has moderate similarity to never in mitosis gene A (NIMA)-related expressed kinase 7 (mouse Nek7), which controls entrance and exit of mitosis and phosphorylates p70 ribosomal S6 kinase ser/thr-protein kinase ZC581.2 ZC581.2 Protein containing two protein kinase domains, has low similarity to casein kinase 1 alpha 1 (rat Csnk1a1), which is a serine/threonine protein kinase that may play a role in signal transduction ser/thr-protein kinase ZC581.3 ZC581.3 Protein of unknown function ZC581.6 ZC581.6 Member of the trypsin family of serine proteases ZC581.7 ZC581.7 Protein containing a Src homology 2 (SH2) domain, which are regulatory modules of intracellular signaling, and a protein kinase domain, has low similarity to fer (fps/fes related) tyrosine kinase (mouse Fert2), which may mediate cell-cell signaling protein-tyrosine kinase ZC581.9 ZC581.9 Protein with strong similarity to C. elegans C17F3.2 gene product ZC64.1 ZC64.1 Member of the transposase family, which are required for excising and inserting mobile genetic elements, contains a retroviral integrase core domain, which can act as endonucleases, has low similarity to TcA transposase (C. elegans C28F5.5) transposase ZC64.2 ZC64.2 Member of the transthyretin-like family, has moderate similarity to uncharacterized C. elegans H14N18.3 ZC64.3 ceh-18;ZC64.3 POU domain homeodomain transcription factor required for gonadal sheath differentiation, has similarity over 495 amino acids to D. melanogaster PDM2 (POU-domain 2) homeodomain transcription factor homeobox protein; ceh-18 encodes a POU-class homeodomain transcription factor; CEH-18 is required in hermaphrodites for specific aspects of gonadal sheath cell differentiation, such as normal cell shape and position, that are essential for negative regulation of oocyte meiotic maturation by the sheath cells; in this process, CEH-18 functions in parallel with the VAB-1/Ephrin receptor as part of a sperm-sensing checkpoint mechanism that prevents oocyte maturation, MAPK activation, and ovulation in the absence of sperm; CEH-18 is expressed in the sheath cell nuclei beginning at the L4 larval stage. ZC64.4 lim-4;ZC64.4 LIM homeodomain transcription factor, has strong similarity to D. melanogaster AWH (arrowhead) LIM homeodomain protein involved in specification of imaginal disk cells, has similarity to human ISL-1 LIM homeodomain protein of islet cells LIM-homeodomain; lim-4 encodes a LIM homeodomain protein homologous to murine Lhx6 and L3/Lhx7, and to Drosophila ARROWHEAD; LIM-4 is required for differentiation of AWB chemosensory neurons, for several but not all aspects of RID motor neuron differentiation, expression of ser-2, repulsion from chemosensory repellants, SAA neurite outgrowth, and normal locomotion and head foraging; lim-4 is expressed in AWB, RID, RIV, RMDL, RMDR, RMEV, four SAA neurons, and four SIA neurons. ZC8.1 ZC8.1 Member of the 3-beta hydroxysteroid dehydrogenase or isomerase family, which are required for steroid hormone synthesis, has low similarity to S. cerevisiae Erg26p, which is a C-3 sterol dehydrogenase and C-4 decarboxylase for ergosterol biosynthesis The ZC8.1 gene encodes a homolog of the human gene 3BH1, which when mutated leads to giant cell hepatitis (OMIM:231100). ZC8.3 ZC8.3 Protein containing an MYND finger domain, has low similarity to uncharacterized C. elegans T22A3.4 ZC8.4 ZC8.4 Putative coiled-coil protein, has similarity to S. cerevisiae ZC8.4 protein, a myosin-like protein probable myofibrillar protein ZC8.6 ZC8.6 Protein of unknown function, has weak similarity to C. elegans C11D2.1 ZC84.1 ZC84.1 Protein containing five kunitz or bovine pancreatic trypsin inhibitor domains and three EB module domains, has a region of low similarity to tissue factor pathway inhibitor (human TFPI), which is a protease inhibitor that inhibits fibrin clot formation Serine protease inhibitor, Kunitz type ZC84.2 tax-4;nCNG1;ZC84.2 Alpha subunit of a cyclic nucleotide-gated channel required for normal chemosensation and thermosensation, AWC sensory neuron olfactory responses, and normal outgrowth and guidance of certain sensory neuron axons Cyclic-nucleotide-gated olfactory channel; tax-4 is orthologous to the human gene ROD PHOTORECEPTOR CGMP-GATED CHANNEL (CNGA1; OMIM:123825), which when mutated leads to disease. ZC84.3 ZC84.3 Protein of unknown function, has moderate similarity to uncharacterized C. elegans R107.6 ZC84.4 ZC84.4 Protein of unknown function, has weak similarity to opiate receptor-like 1 (human OPRL1), which is a G protein-coupled receptor that signals through an inhibitory G protein and may modulate instinctive behaviors and emotions probable G protein coupled receptor ZC84.5 ZC84.5 Protein with strong similarity to C. elegans C38C10.3 gene product ZC84.6 ZC84.6 Protein containing five kunitz or bovine pancreatic trypsin inhibitor domains and three EB module domains, has a region of low similarity to tissue factor pathway inhibitor (human TFPI), which is a protease inhibitor that inhibits fibrin clot formation Serine protease inhibitor ZC97.1 ZC97.1 Has strong similarity to human metaxin 2, (MTX2, involved in protein import into the mitochondria) and weaker similarity to human metaxin 1, MTX1 ZK1005.1 ZK1005.1 Putative paralog of C. elegans Y75B7B.2 pme-5 encodes a poly (ADP-ribose) polymerase (PARP) that is a member of a conserved family of enzymes that catalyze: 1) the synthesis of poly (ADP-ribose), and 2) the covalent attachment of this polymer to glutamic acid residues of acceptor proteins such as histones and topoisomerases in order to regulate cellular processes such as maintenance of chromtin structure, programmed cell death, and DNA replication and repair; as loss of PME-5 function via RNA-mediated interference (RNAi) does not result in any abnormalities, the precise role of PME-5 in C. elegans development and/or behavior is not yet known. ZK1010.1 ubq-2;UbiB;ZK1010.1 Ubiquitin monomer fused to 52 amino acid ribosomal protein L40 UBQ-2 ubiquitin; 60S Ribosomal protein L40; ubq-2 encodes a bifunctional protein that contains two domains; an N-terminal ubiquitin peptide, and a C-terminal large ribosomal subunit protein L40 peptide. ZK1010.2 ZK1010.2 Member of the YagE family, which contain an uncharacterized ACR domain This gene encodes a protein predicted by Eisenberg and coworkers, with 52% accuracy, to be mitochondrial. ZK1010.3 ZK1010.3 Protein of unknown function, has moderate similarity to uncharacterized FSHD region gene 1 (human FRG1) FRG1-like actin crosslinking protein ZK1010.4 ZK1010.4 Protein containing a DB module domain, has high similarity to uncharacterized C. elegans C56C10.4 ZK1010.5 ZK1010.5 Protein of unknown function, has low similarity to a region of proteoglycan 4 (megakaryocyte stimulating factor, human PRG4), which regulates cell proliferation and is associated with camptodactyly-arthropathy-coxa vara-pericarditis syndrome ZK1010.6 ZK1010.6 Protein containing a DX module domain ZK1010.7 ZK1010.7 Potein with high similarity to C. elegans SQT-3, which is a collagen that is involved in morphogenesis of the epithelium and cuticle synthesis, contains two collagen triple helix repeats and one nematode cuticle collagen N-terminal domain collagen ZK1010.8 ZK1010.8 Protein with moderate similarity to C. elegans W06F12.2 gene product ZK1010.9 ZK1010.9 Member of the sodium:neurotransmitter symporter family, has low similarity to gamma aminobutyric acid (GABA) transporter 2 (rat Slc6a13), which is a sodium and chloride-dependent high affinity GABA transporter that modulates GABA levels Sodium:neurotransmitter symporter ZK1025.10 nhr-F;ZK1025.10 Protein containing a nuclear hormone receptor ligand-binding domain and a nuclear hormone receptor C4-type zinc finger domain, has a region of moderate similarity to a region of C. elegans ODR-7, which is involved in AWA-mediated chemosensation Zinc finger, C4 type (two domains) ZK1025.2 ZK1025.2 Member of an uncharacterized protein family ZK1025.3 ZK1025.3 Member of the domain of unknown function DUF13 family, has high similarity to uncharacterized C. elegans E03H4.2 ZK1025.4 ZK1025.4 Member of an uncharacterized protein family ZK1025.5 ZK1025.5 Putative ortholog of C. elegans ZK1025.7 gene product ZK1025.6 ZK1025.6 Protein of unknown function, has high similarity to uncharacterized C. elegans C27C7.8 ZK1025.7 ZK1025.7 Protein of unknown function, has high similarity to uncharacterized C. elegans ZK1025.4 ZK1025.8 ZK1025.8 Member of an uncharacterized protein family ZK1025.9 ZK1025.9 Protein containing nuclear hormone receptor ligand-binding and C4-type zinc finger domains, has a region of low similarity to a region of estrogen related receptor gamma (mouse Esrrg), which is a ligand-independent transcriptional activator Zinc finger, C4 type (two domains) ZK1037.1 ZK1037.1 Member of the 7-transmembrane chemoreceptor family of G protein-coupled receptors (GPCR), contains a DUF41 domain of unknown function ZK1037.10 wrt-7;ZK1037.10 Probable pseudogene, has strong similarity to C. elegans WRT-2, WRT-4, and WRT-8 Hint module ZK1037.11 ZK1037.11 Protein containing a DUF216 domain of unknown function ZK1037.3 ZK1037.3 Protein containing a DUF32 domain of unknown function, has high similarity to uncharacterized C. elegans F47D2.1 ZK1037.4 ZK1037.4 Protein containing a nuclear hormone receptor ligand-binding and C4-type zinc finger domain, and a DUF 227 domain of unknown function, has a region of low similarity to a region of hepatocyte nuclear factor 4 gamma (human HNF4G) Zinc finger, C4 type (two domains) ZK1037.5 ZK1037.5 Member of the nuclear hormone receptor/Zinc finger protein family Ligand-binding domain of nuclear hormone receptors, Zinc finger, C4 type (two domains) ZK1037.6 ZK1037.6 Protein containing a DUF141 domain of unknown function, has moderate similarity to uncharacterized C. elegans C29F3.7 ZK1037.7 ZK1037.7 G protein-coupled receptor of unknown function, no homolog found in human or D. melanogaster 7TM chemoreceptor, srw family ZK1037.8 ZK1037.8 Member of the 7-transmembrane chemoreceptor family of G protein-coupled receptors (GPCR), has high similarity to uncharacterized C. elegans Y94A7B.4 ZK1037.9 ZK1037.9 G protein-coupled receptor of unknown function, no homolog found in human or D. melanogaster 7TM chemoreceptor, srw family ZK105.A ZK105.6;ZK105.A Putative ortholog of C. elegans ZK105_3.A gene product ZK105.B ZK105.5;ZK105.B Putative ortholog of C. elegans ZK105_3.B gene product ZK105.C ZK105.4;ZK105_3.C;ZK105.C Protein with moderate similarity to C. elegans M01B2.7 gene product ZK105.D ZK105.3;ZK105.D Putative ortholog of C. elegans E03H4.4 gene product ZK105.E ZK105.2;ZK105.E Putative ortholog of C. elegans ZK105_3.E gene product ZK1053.1 ZK1053.1 Protein containing a DUF235 domain of unknown function, has high similarity to uncharacterized C. elegans T15D6.9 ZK1053.2 ZK1053.2 Protein of unknown function ZK1053.3 ZK1053.3 Protein of unknown function, has low similarity to uncharacterized C. elegans ZK1053.4 ZK1053.4 ZK1053.4 Protein of unknown function, has low similarity to uncharacterized C. elegans F44F1.7 ZK1053.5 ZK1053.5 Protein with moderate similarity to phospholipid scramblase 2 (mouse Plscr2), which mediates the calcium-dependent transbilayer movement of phospholipids and may be responsible for the redistribution of membrane phospholipids in damaged or apoptotic cells ZK1053.5 encodes a homolog of human scramblase (PLSCR1; OMIM:604170), which is activated by a rise of intracellular calcium, and which promotes the exposure of phosphatidylserine on the surface of cells undergoing activation, injury, or apoptosis; closely related paralogs of ZK1053.5 include C04E12.7 and T22H2.5. ZK1053.6 ZK1053.6 Protein of unknown function, has moderate similarity to C. elegans T20D4.5 ZK1055.1 hcp-1;ZK1055.1 Centromeric protein involved in chromosome segregation hcp-1 encodes a homolog of the mammalian centromere protein-F (CENP-F) and is involved in mitotic chromosome segregation; hcp-1 functions in an ordered pathway consisting of two other CENP proteins encoded by hcp-3 and hcp-4 to control assembly of the kinetochore; hcp-1 localization to the kinetochore is dependent on hcp-3 and hcp-4. ZK1055.2 ZK1055.2 Protein of unknown function, has high similarity to uncharacterized C. elegans F46F5.14 ZK1055.3 ZK1055.3 Protein of unknown function ZK1055.4 ZK1055.4 Protein of unknown function, has high similarity to uncharacterized C. elegans F46F5.14 ZK1055.5 ZK1055.5 Protein of unknown function, has low similarity to uncharacterized C. elegans K06H6.1 ZK1055.6 ZK1055.6 Putative paralog of C. elegans ZK1055.7 gene product ZK1055.7 ZK1055.7 Protein of unknown function, putative paralog of C. elegans ZK1055.6 ZK1058.1 ZK1058.1 Protein with high similarity to methylmalonyl Coenzyme A mutase (human MUT), which is associated with methylmalonic acidemia, member of the methylmalonyl-CoA mutase family, contains a B12 (adenosylcobamide) binding domain Methylmalonyl-coA mutase; ZK1058.1 is orthologous to the human gene METHYLMALONYL CoA MUTASE (MUT; OMIM:251000) which when mutated leads to the mut class of methylmalonic acidemia (methylmalonicaciduria). ZK1058.2 pat-3;ZK1058.2 Putative beta integrin; localizes to dense bodies in multiple muscle tissues; possible ortholog of human integrin, beta 1 (ITGB1) beta integrin ZK1058.3 ZK1058.3 Protein with high similarity to galactose-1-phosphate uridylyltransferase (human GALT), which catalyzes the conversion of UDP-glucose and galactose-1-phosphate to glucose-1-phosphate and UDP-galactose and is associated with galactosemia galactose-1-phosphate uridylyltransferase; ZK1058.3 is orthologous to the human gene UNNAMED PROTEIN PRODUCT (GALT; OMIM:606999), which when mutated leads to disease. ZK1058.4 ZK1058.4 Protein of unknown function, has moderate similarity to uncharacterized human GK001 ZK1058.5 ZK1058.5 Protein of unknown function, has moderate similarity to uncharacterized S. pombe Spbc3h7.11p ZK1058.6 ZK1058.6 Member of the carbon-nitrogen hydrolase family, which hydrolyze carbon-nitrogen bonds, has low similarity to uncharacterized S. pombe Spcc965.09p Nitrilase ZK1058.9 ZK1058.9 Protein of unknown function ZK1067.1 let-23;kin-7;ZK1067.1 Tyrosine kinase receptor of the EGF-receptor family; required for vulval induction, larval viability, hermaphrodite fertility, male spicule development, and posterior epidermal development tyrosine-protein kinase (Epidermal growth factor receptor subfamily); The let-23 gene encodes a member of the EGF-receptor family of transmembrane tyrosine kinases that affects viability, inductive signaling during development of the vulva, male spicule formation, posterior development of the epidermis, and ovulation; it is genetically upstream of the let-60/RAS pathway with respect to viability and vulval development, is upstream of the IP3 pathway with respect to fertility, and is expressed in vulval precursor cells. ZK1067.2 ZK1067.2 Protein of unknown function, has a region of low similarity to a region of C. elegans SMG-2, which is involved in nonsense-mediated mRNA decay, mRNA surveillance and RNAi-mediated gene suppression ZK1067.3 ZK1067.3 Protein of unknown function ZK1067.4 ZK1067.4 Protein of unknown function ZK1067.4 is orthologous to the human gene PROTEOLIPID PROTEIN 1 (PLP1; OMIM:300401), encoding the primary constituent of myelin, which when mutated leads to Pelizaeus-Merzbacher disease (OMIM:312080). ZK1067.5 twk-20;ZK1067.5 Member of the 4 TM potassium channel protein family potassium channel protein ZK1067.6 ZK1067.6 Protein containing three RNA recognition motifs (RRM, RBD, or RNP), has a region of low similarity to g rich RNA sequence binding factor 1 (human GRSF1), which binds to G-rich elements of poly(A)+ mRNA and may regulate polyadenylation and translation hnRNP F protein like ZK1067.7 ZK1067.7 Protein containing six uncharacterized DUF139 cysteine repeat domains, has low similarity to uncharacterized C. elegans F35A5.4 The protein product of this gene is predicted to contain a glutamine/asparagine (Q/N)-rich ('prion') domain, by the algorithm of Michelitsch and Weissman (as of the WS77 release of WormBase, i.e., in wormpep77). ZK1073.1 ZK1073.1 Member of the Ndr family, which are involved in cell differentiation, has low similarity to n-myc downstream regulated gene 1 (human NDRG1), which is induced by nickel, homocysteine, 2-mercaptoethanol, and tunicamycin ZK1073.2 ZK1073.2 Protein of unknown function ZK1086.1 ZK1086.1 Member of the oxysterol-binding protein (OSBP) family, which are involved in sterol biosynthesis, contains a pleckstrin homology (PH) domain, has a region of moderate similarity to S. cerevisiae Osh7p, which functions in sterol metabolism Yeast hypothetical protein YHG1 like; ZK1086.1 encodes two isoforms of a protein with an N-terminal pleckstrin domain and a C-terminal oxysterol-binding domain; ZK1086.1 has orthologs in Drosophila (CG5077) and humans (OSBPL8; OMIM:606736); ZK1086.1 binds the BMP receptor associated molecule (BRAM) proteins BRA-1 and BRA-2; ZK1086.1 is expressed in pharyngeal muscle, hypodermis, and several neurons; ZK1086.1 is required for normally large body size, and the small body phenotype of ZK1086.1(RNAi) animals is consistent with ZK1086.1 participating in TGF-beta signalling. ZK1086.2 ZK1086.2 Protein of unknown function ZK1086.3 ZK1086.3 Member of the domain of unknown function DUF13 family, has high similarity to uncharacterized C. elegans T15D6.8 ZK1098.1 ZK1098.1 Member of the WWP domain protein family WW/rsp5/WWP domain containing proteins (2 domains); ZK1098.1 encodes a protein, with multiple WW/rsp5/WWP domains and FF domains, required for embryonic viability and for normally high rates of postembryonic growth. ZK1098.10 unc-16;egl-39;ZK1098.10 Protein with moderate similarity to mitogen-activated protein kinase 8 interacting protein 3 (mouse Mapk8ip3), which is a scaffold protein that binds the Jun N-terminal kinase signaling complex and facilitates JNK activation in response to cellular stress Coiled coil protein; unc-16 encodes a homolog of murine JIP3/JSAP and Drosophila SUNDAY DRIVER that is involved in vesicle transport, and that affects egg laying, locomotion, and defecation and physically interacts with JNK and JNK kinases; UNC-16 is expressed in neurons of the ventral cord, retrovesicular and preanal ganglia, the nerve ring, intestinal cells, seam and hypodermal cells, body wall and head muscle, and pharynx. ZK1098.2 ZK1098.2 Protein with strong similarity to C. elegans C09E7.4 gene product ZK1098.3 ZK1098.3 Protein containing a 3'-5' exonuclease domain, which catalyze the hydrolysis of mismatched or unpaired nucleotides, has low similarity to C. elegans MUT-7, which is involved in transposon mobilization and RNA-mediated interference ribonuclease D; This gene encodes a protein predicted by Eisenberg and coworkers, with 52% accuracy, to be mitochondrial. ZK1098.4 ZK1098.4 Member of the initiation factor 2 subunit family, has moderate similarity to eukaryotic translation initiation factor 2B alpha (rat Eif2b1), which is a putative subunit of the EIF2B complex that facilitates an exchange of GDP for GTP GCN3 (yeast transcription activator) ZK1098.5 ZK1098.5 Protein with moderate similarity to S. cerevisiae Bet3p, which is a subunit of Transport Protein Particle I complex involved in targeting and fusion of ER to Golgi transport vesicles ZK1098.5 encodes a unfamiliar protein that is individually dispensable for viability and gross morphology in RNAi assays, but is cotranscribed with ZK1098.1 and thus might act in concert with it. ZK1098.6 ZK1098.6 Protein of unknown function, has a probable coiled-coil domain Coiled coil protein; ZK1098.6 encodes a coiled-coil protein that is individually dispensable for viability and gross morphology in RNAi assays, but is cotranscribed with ZK1098.1 and thus might act in concert with it. ZK1098.7 ZK1098.7 Possible mitochondrial small subunit protein ZK1098.8 mut-7;ZK1098.8 Involved in transposon mobilization and RNA-mediated interference that has similarity to E. coli RNaseD ribonuclease D; mut-7 encodes a homolog of RnaseD that represses transposition of Tc1, Tc3, Tc4, and Tc5, perhaps by degrading transposon-specific messages; also affects sperm development, sensitivity to RNAi of mainly germline expressed genes, silencing of some germline transgenes, X chromosome loss, and is required for cosuppression (functional silencing of chromosomal loci induced by transgenes) and for silencing induced by antisense RNA oligomers. ZK1098.9 ZK1098.9 Protein of unknown function ZK112.1 ZK112.1 Member of the carboxypeptidase protein family ZK112.2 ncl-1;ZK112.2 B box zinc finger protein involved in repressing RNA polymerase I and RNA polymerase III to limit cell growth; putative repressor of ribosome synthesis xnf7; ncl-1 encodes a B-box zinc finger protein that may be a repressor of RNA polymerase I and III transcription and an inhibitor of cell growth, based on mutant analysis; appears to function in a cell autonomous fashion. ZK112.3 ZK112.3 Protein of unknown function ZK112.4 ZK112.4 Protein of unknown function ZK112.5 ZK112.5 Protein of unknown function ZK112.6 ZK112.6 Protein of unknown function ZK112.7 cdh-3;ZK112.7 Cadherin superfamily member required for proper tail morphogenesis fat tumor suppressor; cdh-3 encodes a member of the cadherin superfamily that affects morphogenesis of tail epithelia and excretory function; expressed predominantly in developing epithelial cells, and also expressed in the AC, excretory cell, various neurons, and vulval cells during different stages of development. ZK1127.1 nos-2;ZK1127.1 Protein that functions in development of the germ lineage, has similarity to D. melanogaster nanos nos-2 encodes one of three genes in C. elegans that contains a putative zinc-binding domain similar to the one found in Drosophila nanos; nos-2 affects incorporation of primordial germ cells into the somatic gonad, is required redundantly with nos-1 to prevent primordial germ cells from dividing in starved animals and to maintain germ cell viability during larval development in hermaphrodites and in males, and also functions together with nos-1 and nos-3 in the hermaphrodite switch from spermatogenesis to oogenesis; nos-2 is expressed in the primordial germ cells around the time of gastrulation from a maternal RNA associated with P granules, and it is expressed coordinately with nos-1in a dynamic fashion until the embryonic 200-cell stage. ZK1127.10 ZK1127.10 Protein with high similarity to cystathionase (human CTH), which is a pyridoxal phosphate-dependent enzyme that acts in the conversion of cystathionine into cysteine, member of the cysteine-methionine metabolism pyridoxal-phosphate-dependent enzyme family cystathionine gamma-lyase; ZK1127.10 is orthologous to the human gene UNKNOWN (PROTEIN FOR MGC:9471) (CTH; OMIM:219500), which when mutated leads to disease. ZK1127.11 him-14;ZK1127.11 Protein required for meiotic recombination recombiation protein; This gene encodes a protein predicted by Eisenberg and coworkers, with 52% accuracy, to be mitochondrial. ZK1127.12 ZK1127.12 Protein of unknown function ZK1127.2 ZK1127.2 Member of the AMP-binding enzyme family, has low similarity to C. albicans Acs1p, which is an acetyl-coenzyme A synthetase (acetate-coA ligase) COA ligase ZK1127.3 ZK1127.3 Protein with weak similarity to S. cerevisiae YNL136W ZK1127.4 ZK1127.4 Protein of unknown function ZK1127.5 ZK1127.5 Member of the RNA 3'-terminal phosphate cyclase protein family ZK1127.6 ZK1127.6 Protein containing five FF domains, which may be involved in protein-protein interactions, has moderate similarity to a region of TATA box binding protein (TBP)-associated factor RNA polymerase II S 150kD (human TCERG1) ZK1127.7 ZK1127.7 Member of the DNA gyrase or topoisomerase IV subunit A family, has high similarity to a region of DNA topoisomerase II alpha (human TOP2A), which has diverse roles in DNA replication, chromosome condensation and cell cycle control This gene encodes a protein predicted by Eisenberg and coworkers, with 52% accuracy, to be mitochondrial. ZK1127.9 ZK1127.9 Member of the WWP domain protein family ZK1128.1 ZK1128.1 Protein containing an uncharacterized ACR domain, has low similarity to uncharacterized C. albicans Orf6.5662p This gene encodes a protein predicted by Eisenberg and coworkers, with 68% accuracy, to be mitochondrial. ZK1128.2 ZK1128.2 Protein of unknown function, has low similarity to uncharacterized S. pombe Spac27d7.08cp ZK1128.3 ZK1128.3 Protein of unknown function ZK1128.4 ZK1128.4 Protein with low similarity to general transcription factor IIH polypeptide 3 34kD subunit (human GTF2H3), which is part of the TFIIH core involved in transcription and nucleotide excision repair ZK1128.5 ZK1128.5 Putative 60 KDa subunit of SWI/SNF complex, possible ortholog of human SMARCD3 (Hs.77069, SWI/SNF-related, actin-dependent regulator of chromatin) D15Kz1 protein homolog; The ZK1128.5 gene encodes a homolog of Swp73/BAF60, a component of the SWI/SNF complex that is conserved from yeast to mammals and that is involved in chromatin remodeling; ZK1128.5 may be involved in asymmetric cell division of the T cells. ZK1128.6 ZK1128.6 Member of the tubulin-tyrosine ligase family tubulin tyrosine ligase ZK1128.7 ZK1128.7 Member of the Hsp20 or alpha crystallin family alpha-B-crystallin ZK1128.8 ZK1128.8 Protein of unknown function ZK1151.1 ZK1151.1 Protein containing five spectrin repeats, which are involved in cytoskeletal structure, two calponin homology (CH) domains, which bind actin, and a Src homology 3 (SH3) domain, which bind peptides, has low similarity to a region of plectin 1 (human PLEC1) vab-10 encodes, by alternative splicing, two spectraplakins (VAB-10A and VAB-10B) that are jointly required for mechanical resilience of the epidermis under strain by the contraction of actin microfilaments mechanically linked to fibrous organelles (FOs); VAB-10A/B are, accordingly, required for elongation during embryonic morphogenesis; VAB-10A has C-terminal plectin repeats while VAB-10B has spectrin repeats; VAB-10A is required to keep the epidermis and extracellular matrix attached via FOs, while VAB-10B is required to keep the apical and basal epidermal plasma membranes connected during morphogenesis; vab-10a and vab-10b mutations complement one another; vab-10 is orthologous to human BPAG1 (dystonin or MACF2, OMIM:113810, encoding an autoantigen of bullous pemphigoid blistering disease) and dJ562N20.1 (MACF1), and to Drosophila SHORT STOP. ZK1151.2 ZK1151.2 Putative coiled-coil protein, has strong similarity to D. melanogaster KAK (kakapo, a large cytoskeletal linker protein), has similarity to human and D. melanogaster alpha spectrins ZK1151.3 ZK1151.3 Protein with weak similarity to H. sapiens PLEC1 (plectin 1, intermediate filament binding protein, 500kD) ZK1193.1 col-19;col19;ZK1193.1 Collagen, temporally regulated during the switch between the larval and adult developmental pathways cuticular collagen; col-19 encodes a member of the collagen superfamily containing collagen triple helix repeats (20 copies) that is required for normal structure of the alae; expressed during the L2-to-dauer and L4-to-adult molts with strongest expression in adult animals. ZK1193.2 ZK1193.2 Member of the EGF-repeat protein family, member of the C-type lectin family ZK1193.3 ZK1193.3 Protein with strong similarity to C. elegans F40F4.6 gene product ZK1193.4 ZK1193.4 Protein of unknown function ZK1193.5 ZK1193.5 Protein containing a homeobox domain (homeodomain), which are found in transcription factors ZK1193.5 encodes, by alternative splicing, three proteins with a COMPASS (CMP) domain and two homeodomains; the CMP domain is found in the N-terminus of SATB-class CUT homeodomain proteins (e.g. human SATB1), and in Drosophila DEFECTIVE PROVENTRICULUS (DVE), to which ZK1193.5 may be orthologous; both DVE and ZK1193.5 encode two homeodomains which are highly divergent, but homologous between species, and probably derived by intragenic duplication; ZK1193.5 is required for a normally high rate of growth, fluid excretion, and larval viability in in mass RNAi assays. ZK121.1 ZK121.1 Protein with strong similarity to C. elegans ZK121.B ZK121.2 ZK121.2 Putative paralog of C. elegans ZK121.C ZK1225.1 ZK1225.1 Protein containing a DUF235 domain of unknown function, has moderate similarity to uncharacterized C. elegans C17A2.6 ZK1225.2 ZK1225.2 Member of the core-2 or I-branching enzyme family, which form blood group I-antigens or side-chains of O-glycans, has weak similarity to beta-1 6-N-acetylglucosaminyltransferase-mucin type (human GCNT3), which forms O-glycan branches in mucins ZK1225.3 ZK1225.3 Member of the transposase family, which are required for excising and inserting mobile genetic elements, has very strong similarity to uncharacterized C. elegans E03H4.1 transposase ZK1225.4 ZK1225.4 Protein of unknown function, has high similarity to uncharacterized C. elegans ZK1225.5 ZK1225.5 ZK1225.5 Protein of unknown function, has high similarity to uncharacterized C. elegans ZK1225.4 ZK1225.6 ZK1225.6 Protein containing a major sperm protein (MSP) domain, which are involved in sperm motility, has strong similarity to uncharacterized C. elegans R08A2.3 ZK1236.1 ZK1236.1 Protein containing an elongation factor Tu GTP binding domain and an elongation factor Tu domain 2, which adopt a beta barrel structure, has a region of weak similarity to a region of mitochondrial translation elongation factor G (S. cerevisiae Mef1p) homology with E.coli lepA protein ZK1236.2 cec-1;ZK1236.2 Member of the 'chromo' (CHRromatin Organization MOdifier) Domain protein family Nucleolin; cec-1 encodes a nuclear protein with a chromodomain that is ubiquitously expressed in somatic cells, but is dispensable for embryonic survival or gross adult morphology. ZK1236.3 ZK1236.3 Protein of unknown function ZK1236.4 ZK1236.4 Member of the reverse transcriptase protein family, which are RNA-dependent DNA polymerases, has high similarity to uncharacterized C. elegans R05F9.4 transposon T1-2 ZK1236.5 ZK1236.5 Protein of unknown function ZK1236.6 ZK1236.6 Protein of unknown function The protein product of this gene is predicted to contain a glutamine/asparagine (Q/N)-rich ('prion') domain, by the algorithm of Michelitsch and Weissman (as of the WS77 release of WormBase, i.e., in wormpep77). ZK1236.7 ZK1236.7 Protein of unknown function, has moderate similarity to uncharacterized human C20orf116 ZK1236.8 ZK1236.8 Protein of unknown function ZK1240.1 ZK1240.1 Member of the B-box zinc finger family, contains a C3HC4 type (RING) zinc finger, which may mediate protein-protein interactions, has low similarity to a region of ADP-ribosylation factor domain protein 1 (human ARFD1), which is a GTPase ZK1240.2 ZK1240.2 Member of the B-box zinc finger family, contains a C3HC4 type (RING) zinc finger, which may mediate protein-protein interactions, has a region of low similarity to a region of ADP-ribosylation factor domain protein 1 (human ARFD1), which is a GTPase ZK1240.3 ZK1240.3 Member of the B-box zinc finger family, contains a C3HC4 type (RING) zinc finger, which may mediate protein-protein interactions, has moderate similarity to uncharacterized C. elegans ZK1240.8 ZK1240.4 ZK1240.4 Protein with strong similarity to C. elegans B0281.8 gene product ZK1240.5 ZK1240.5 Protein of unknown function, has high similarity to uncharacterized C. elegans B0281.8 ZK1240.6 ZK1240.6 Protein containing a C3HC4 type (RING) zinc finger, which may mediate protein-protein interactions ZK1240.8 ZK1240.8 Member of the B-box zinc finger family, contains a C3HC4 type (RING) zinc finger, which may mediate protein-protein interactions, has moderate similarity to uncharacterized C. elegans ZK1240.3 ZK1240.9 ZK1240.9 Protein with strong similarity to C. elegans ZK1240.3 gene product ZK1248.1 ZK1248.1 Member of the M13 peptidase family of zinc metalloproteases, has weak similarity to uncharacterized C. elegans C53B7.7 ZK1248.1 encodes a neprilysin; neprilysins are thermolysin-like zinc metallopeptidases, found on the outer surface of animal cells, that negatively regulate small signalling peptides (e.g., enkephalin, tachykinin, insulin, and natriuretic peptides) by cleaving them; ZK1248.1 has no clear orthologs in other organisms. ZK1248.10 ZK1248.10 Protein of unknown function, has similarity over the C-terminus to a number of human, S. cerevisiae, and C. elegans proteins, including human Rab-GAP/TBC-containing protein ZK1248.11 ZK1248.11 Protein with weak similarity to S. cerevisiae MMS21 (Protein involved in DNA repair) ZK1248.12 ZK1248.12 Protein of unknown function ZK1248.13 ZK1248.13 Protein of unknown function ZK1248.14 ZK1248.14 Protein of unknown function, has moderate similarity to uncharacterized human MFN2 ZK1248.15 ZK1248.15 Protein containing a WW domain, which bind proline-rich peptide epitopes ZK1248.16 lec-5;ZK1248.16 Member of the galectin family, has moderate similarity to galectin (C. elegans LEC-1), which is a galactoside-binding lectin ZK1248.17 ZK1248.17 Protein with high similarity to C. elegans MSP-142, which is a sperm-specific protein involved in sperm motility, contains a major sperm protein (MSP) domain, which are involved in sperm motility major sperm protein ZK1248.2 ZK1248.2 Protein with high similarity to C. elegans SQT-1, which is a collagen involved in morphogenesis, regualation of body size and cuticle synthesis, contains two collagen triple helix repeats ZK1248.3 ehs-1;ZK1248.3 Protein with similarity to human EPS15 (epidermal growth factor receptor pathway substrate 15, also known as AF1P, associated with mixed-lineage leukemia); involved in synaptic vesicle cycling The ehs-1 gene encodes an ortholog of mammalian EPS15 that probably functions in endocytosis. ZK1248.4 ZK1248.4 Protein of unknown function, has very strong similarity to a region of C. elegans MSP-152, which is a major sperm protein involved in sperm motility Major sperm protein ZK1248.5 ZK1248.5 Protein of unknown function, has low similarity to uncharacterized C. elegans C28D4.8 ZK1248.6 msp-64;msp-64ps;ZK1248.6 Major sperm protein required for spermatogenesis in C. elegans Major sperm protein; msp-64 encodes a protein that belongs to a family of proteins called the Major Sperm Proteins (MSPs) that is conserved in nematodes; this family consists of closely related, small, basic proteins that make up 15% of sperm protein; this multigene family consists of over fifty genes, including many pseudogenes; MSPs are involved in both extracellular signaling and cytoskeletal functions during reproduction-MSP antagonizes Eph/ephrin signaling, in part, by binding VAB-1 Eph receptor tyrosine kinase on oocytes and sheath cells to promote oocyte maturation and MAPK activation; MSPs assemble into fibrous networks that drive movement of the C. elegans sperm; msp genes are expressed only in late primary spermatocytes. ZK1248.7 ZK1248.7 Protein containing a piwi domain, has low similarity to a region of C. elegans ALG-1, which plays a role in the production of stRNA (small temporal RNA) C. elegans LIN-4 and that functionally overlaps with C. elegans ALG-2 ZK1248.8 ZK1248.8 Protein with strong similarity to C. elegans F55A12.1 gene product ZK1248.9 ZK1248.9 Putative ortholog of C. elegans F55A12.1 gene product ZK1251.1 ZK1251.1 Protein with high similarity to histone H2A (S. cerevisiae Hta1p), which is involved in chromosome organization and biogenesis and nucleosome assembly, member of the histone family of nucleosomal core proteins histone H2A ZK1251.2 ins-7;ZK1251.2 Insulin-like protein of the type-beta subfamily ins-7 encodes an insulin-like peptide of the insulin superfamily of proteins (OMIM:176730, 147440); INS-7 is one of 38 insulin-like peptides in C. elegans and is expressed in the amphid sensory neurons, labial neurons, the nerve ring, and other neurons; the precise role of INS-7 in C. elegans development is not yet clear as loss of function does not result in a mutant phenotype. ZK1251.3 ZK1251.3 Member of the 3-oxo-5-alpha-steroid 4-dehydrogenase protein family 3-oxo-5-alpha-steroid 4-dehydrogenase ZK1251.4 ZK1251.4 TcA transposase Tc1 transposase ZK1251.5 ZK1251.5 Putative paralog of C. elegans ZK354.8, has strong similarity to C. elegans B0207.1, a putative tyrosine protein phosphatase ZK1251.6 ZK1251.6 Protein with very strong similarity to C. elegans MSP-10, which is involved in oocyte maturation, contains a major sperm protein (MSP) domain, which are involved in sperm motility major sperm protein (MSP1); msp-76 encodes a protein that belongs to a family of proteins called the Major Sperm Proteins (MSPs) that is conserved in nematodes; this family consists of closely related, small, basic proteins that make up 15% of sperm protein; this multigene family consists of over fifty genes, including many pseudogenes; MSPs are involved in both extracellular signaling and cytoskeletal functions during reproduction-MSP antagonizes Eph/ephrin signaling, in part, by binding VAB-1 Eph receptor tyrosine kinase on oocytes and sheath cells to promote oocyte maturation and MAPK activation; MSPs assemble into fibrous networks that drive movement of the C. elegans sperm; msp genes are expressed only in late primary spermatocytes. ZK1251.7 ZK1251.7 Protein of unknown function ZK1251.8 twk-21;ZK1251.8 Member of the 4 TM potassium channel protein family potassium channel protein ZK1251.9 ZK1251.9 Putative ortholog of H. sapiens Hs.193609 (Homo sapiens mRNA for KIAA0800 protein, complete cds) ZK1290.1 ZK1290.1 Protein of unknown function ZK1290.10 ZK1290.10 Protein of unknown function ZK1290.11 ZK1290.11 Protein of unknown function ZK1290.12 wrt-1;ZK1290.12 Putative paralog of C. elegans WRT-7, contains similarity to a Hint module (hedgehog/intein) domain warthog gene ZK1290.2 tph-1;ZK1290.2 Tryptophan hydroxylase involved in serotonin biosynthesis Biopterin-dependent aromatic amino acid hydroxylase; tph-1 homozygous animals lack velocity burst prior to egg laying, as well as the peak in the directional change probability following the egg laying. ZK1290.3 rol-8;col-6;ZK1290.3 Collagen that is structurally similar to vertebrate type IX collagens Cutical collagen 6, col-6; rol-8 encodes a collagen that is enriched in dauer larvae; mutations cause adults to become left-handed rollers. ZK1290.4 nfi-1;ZK1290.4 Member of the CCAAT box-binding transcription factor or nuclear factor I family, which bind DNA, has a region of high similarity to a region of nuclear factor I-C (mouse Nfic), which is a CCAAT-binding cellular and viral transcription factor Nuclear factor 1 ZK1290.5 ZK1290.5 Member of the aldo-keto reductase family, which include some related monomeric NADPH-dependent oxidoreductases, has low similarity to (mouse Akr1a4), which is an NADPH-dependent aldo-keto reductase that reduces carbonyl-containing substrates Aldo/keto reductase ZK1290.6 ZK1290.6 Member of the RNase H family, which digest the RNA strand of an RNA-DNA duplex, has a region of low similarity to ribonuclease H1 (human RNASEH1), which binds to double stranded RNA and DNA-RNA hybrids and degrades the RNA strand of DNA-RNA hybrids ZK1290.7 ZK1290.7 Protein of unknown function, has weak similarity to C. elegans R09H10.2 ZK1290.8 wrt-10;ZK1290.8 Protein of unknown function, has a Wart domain that is found in Warthog-related proteins ZK1290.9 ZK1290.9 Protein containing a DUF38 domain of unknown function and an F-box domain, which serve as a link between a target protein and a ubiquitin-conjugating enzyme, has moderate similarity to uncharacterized C. elegans Y102A5C.3 This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins; this gene's encoded protein also contains an FTH/DUF38 motif, which may also mediate protein-protein interaction. ZK1307.1 ZK1307.1 Protein of unknown function, has strong similarity to C. elegans F38H4.5 ZK1307.2 ZK1307.2 Protein of unknown function ZK1307.3 ZK1307.3 Protein containing a major sperm protein (MSP) domain, which are involved in sperm motility, has strong similarity to uncharacterized C. elegans ZK1307.4 ZK1307.4 ZK1307.4 Protein containing a major sperm protein (MSP) domain, which are involved in sperm motility, has strong similarity to uncharacterized C. elegans ZK1307.3 ZK1307.5 sqv-8;spe-2;ZK1307.5 Glucuronyl transferase-I (GlcAT-I), involved in proteoglycan biosynthesis, important for vulval invagination The sqv-8 gene encodes a glucuronyl transferase, biochemically active in vitro, that is required for cytokinesis of one-cell embryos and for vulval morphogenesis; SQV-8 is homologous to three distinct glucuronyl transferases (GlcAT-I, GlcAT-P and GlcAT-D) that play a role in the synthesis of different glycoconjugates; the common requirement for SQV-8 in both cytokinesis and morphogenesis may be to promote filling an extracellular space with hygroscopic proteoglycans (either in the eggshell, or underneath the L4 cuticle), which in turn may cause the space to fill with fluid. ZK1307.6 ZK1307.6 Putative ortholog of S. cerevisiae Cdh1p and of Drosophila fzr, proteins that are involved in cyclin desctruction CDC20 protein; fzr-1 encodes a WD repeat-containing protein homologous to Cdh1/Hct1/FZR (OMIM:603619), a regulatory subunit of the anaphase-promoting complex/cyclosome (APC/C) required for anaphase initiation and exit from mitosis; FZR-1 is required for fertility, and also functions redundantly with lin-35/Rb to for normal embryogensis and control of postembryonic cell proliferation; FZR-1 probably regulates the levels of G1 cyclins, degradation of which is critical for G1 arrest. ZK1307.7 ZK1307.7 G protein-coupled receptor with weak similarity to human endothelial differentiation, sphingolipid G protein-coupled receptor 7 transmembrane receptor (rhodopsin family) ZK1307.8 ZK1307.8 Protein containing an EF hand domain, which are found in signaling, buffering or transport proteins, has moderate similarity to protein kinase C substrate 80K-H (human PRKCSH), which is a protein phosphorylated by types I and II protein kinase C protein kinase C substrate ZK1307.9 ZK1307.9 Protein of unknown function, has moderate similarity to uncharacterized human MGC10471 YJU2 protein ZK131.1 ZK131.1 Protein with strong similarity to histone 4.3 (S. pombe Hhf3p), member of the histone family of nucleosomal core proteins histone H4; his-26 encodes an H4 histone. ZK131.10 his-16;ZK131.10 Member of the histone H2A protein family histone H2A; his-16 encodes an H2A histone; his-16 is contained within the histone gene cluster HIS3. ZK131.11 ZK131.11 Protein of unknown function ZK131.2 ZK131.2 Member of the H3 histone protein family histone H3; his-25 encodes an H3 histone. ZK131.3 his-9;ZK131.3 Member of the H3 histone protein family histone H3; his-9 encodes an H3 histone; by homology, HIS-9 is predicted to function as a nucleosome component required for packaging of DNA into chromatin; his-9 is a replication-dependent histone locus that resides in the HIS3 cluster on chromosome II. ZK131.4 ZK131.4;his-10 Protein with very strong similarity to H4 histone family member E (human H4FE), which is a chromatin assembly complex component that may play a role in the condensation of DNA into nucleosomes, member of the histone family of nucleosomal core proteins histone H4; his-10 encodes an H4 histone. ZK131.5 ZK131.5;his-11 Member of the histone H2B protein family histone H2B; his-11 encodes an H2B histone; by homology, HIS-11 is predicted to function as a nucleosome component required for packaging of DNA into chromatin; his-11 is a replication-dependent histone locus that resides in the HIS3 cluster on chromosome II. ZK131.6 his-12;ZK131.6 Protein with very strong similarity to C. elegans HIS-16, which is involved in cell migration, regulation of body size and DNA packaging, member of the histone family of nucleosomal core proteins histone H2A; his-12 encodes an H2A histone; his-12 is contained within the histone gene cluster HIS3. ZK131.7 his-13;ZK131.7 Member of the histone H3 protein family histone H3; his-13 encodes an H3 histone; his-13 is contained within the histone gene cluster HIS3. ZK131.8 his-14;ZK131.8 Protein with very strong similarity to H4 histone family member E (human H4FE), which is a chromatin assembly complex component that may have a role in the condensation of DNA into nucleosomes, member of the histone family of nucleosomal core proteins histone H4; his-14 encodes an H4 histone. ZK131.9 his-15;ZK131.9 Member of the histone H2B protein family histone H2B; his-15 encodes an H2B histone. ZK1320.1 ZK1320.1 Member of the 2-hydroxychromene-2-carboxylate isomerase protein family, which are involved in prokaryotic polyaromatic hydrocarbon (PAH) catabolism, has low similarity to uncharacterized human LOC51064 ZK1320.10 nlp-11;ZK1320.10 LxDxamide neurotransmitter ZK1320.11 ZK1320.11 Protein with moderate similarity to C. elegans Y43F8B.12 gene product ZK1320.12 ZK1320.12 Protein of unknown function ZK1320.2 ZK1320.2 Protein of unknown function, has strong similarity to uncharacterized C. elegans ZK1320.3 ZK1320.3 ZK1320.3 Protein of unknown function, has strong similarity to uncharacterized C. elegans ZK1320.2 ZK1320.4 ZK1320.4 Member of the cytochrome P450 family, has low similarity to cytochrome P450 subfamily 3a polypeptide 9 (rat Cyp3a9), which is a sexually dimorphically expressed enzyme that demethylates erythromycin and benzphetamine cytochrome P450 ZK1320.5 ZK1320.5 Protein of unknown function ZK1320.6 ZK1320.6 Member of the ADP-ribosylation factor (ARF) family, which are GTP-binding proteins involved in protein trafficking, has moderate similarity to rat Arfd1, which is a GTPase that stimulates cholera toxin ADP-ribosyltransferase activity ADP-ribosylation factors (Arf family) (contains ATP/GTP binding P-loop), Zinc finger, C3HC4 type (RING finger); arc-1 encodes a member of the ARL (ADP-ribosylation factor(ARF)-like) family of proteins which are very similar to ARF proteins but lack the ability to stimulate ADP ribosylation by cholera toxin; arc-1 has a human homolog, MID1, which when mutated leads to Opitz syndrome (OMIM:300000). ZK1320.7 ZK1320.7 Protein containing a G-patch domain, which are found in RNA processing proteins, and ankyrin (Ank) repeats, which may mediate protein-protein interactions single ankyrin motif ZK1320.8 ZK1320.8 Member of the reverse transcriptase protein family, which are RNA-dependent DNA polymerases, has high similarity to uncharacterized C. elegans C31C9.5 Reverse transcriptase ZK1320.9 ZK1320.9 Member of the Acetyl-CoA hydrolases or transferase family acetate utilisation protein ZK1321.1 ZK1321.1 Protein of unknown function ZK1321.2 nShak1;ZK1321.2 Putative voltage-gated potassium channel potassium channel protein; ZK1321.2 encodes at least four isoforms of a SHAKER/Kv1 ortholog, which encodes voltage-dependent potassium channels expressed in muscle. ZK1321.3 ZK1321.3 Protein of unknown function, has low similarity to uncharacterized C. elegans ZK525.2 ZK1321.4 ZK1321.4 Protein of unknown function, has weak similarity to C. elegans T11B7.4 ZK154.1 ZK154.1 Protein of unknown function ZK154.3 mec-7;mec-11;tub-2;ZK154.3 Beta tubulin expressed specifically in touch receptor neurons beta tubulin; mec-7 encodes a beta-tubulin required for touch sensitivity along the body wall, and for normal levels of locomotor activity; it is strongly expressed in six touch receptor neurons, with weak expression in FLP, PVD, and BDU cells. ZK154.4 ZK154.4 Protein of unknown function ZK154.5 ZK154.5 Protein with strong similarity to C. elegans W02D9.4 gene product ZK154.6 ZK154.6 Protein of unknown function ZK154.7 adm-4;ZK154.7 Protein with low similarity to A disintegrin and metalloproteinase domain 17 (tumor necrosis factor alpha converting enzyme, human ADAM17), which stimulates TNF release and may be associated with cardiomyopathy, osteoarthritis, and Alzheimer's disease metalloprotease; adm-4 encodes a member of the ADAM (disintegrin plus metalloprotease) family; ADM-4 is highly expressed in most post-embryonic tissues. ZK177.1 ZK177.1 Protein with weak similarity to H. sapiens TAF2N (TATA box binding protein (TBP)-associated factor, RNA polymerase II, N, 68kD (RNA-binding protein 56)) ZK177.10 ZK177.10 Protein containing a T-box domain, which bind DNA ZK177.2 ZK177.2 Protein containing a protein kinase domain, has weak similarity to uncharacterized C. elegans C04G2.10 ZK177.3 ZK177.3 Protein containing three C2H2 type zinc finger domains, which bind nucleic acids Zinc finger-like ZK177.4 ZK177.4 Protein with weak similarity to C. elegans F41H10.4 ZK177.5 cyp-44;ZK177.5 Member of the cytochrome P450 family, has low similarity to 1,25-dihydroxyvitamin D3 24-hydroxylase (rat Cyp24), which is a cytochrome P450 enzyme that catalyzes 24-hydroxylation of 25-hydroxyvitamin D3 cytochrome p450; ccp-44 encodes a cytochrome P450 that is most closely related to the mammalian CYP24A1 enzymes (OMIM:126065, also known as vitamin D 24-hydroxylase, overexpression is associated with albuminuria and hyperlipidemia); by homology, CCP-44 is predicted to function as a monooxygenase that, during electron transport, catalyzes the oxidative degradation of various metabolites and the synthesis of cholesterol, steroids, and lipids; however, as loss of ccp-44 function via RNA-mediated interference (RNAi) does not result in any obvious abnormalities, the precise role of CCP-44 in C. elegans development and/or behavior is not yet known. ZK177.6 ZK177.6 Member of the WD repeat protein family CDC20 ZK177.8 ZK177.8 Protein containing two HD domains ZK177.9 ZK177.9 Protein of unknown function ZK180.1 ZK180.1 Member of the metabotrobic glutamate family of G-protein coupled receptors (GPCR), has a region of moderate similarity to a region of human GPR51, which is a gamma-aminobutyric acid B receptor 2 that functions as an inhibitory neurotransmitter receptor ZK180.2 ZK180.2 Protein with moderate similarity to C. elegans Y41G9A.4 gene product ZK180.3 ZK180.3 Protein with weak similarity to S. cerevisiae Rft1p, which is required for N-linked glycosylation ZK180.4 opu-9;inx-9;ZK180.4 Protein with high similarity to S. cerevisiae Sar1p, which is a component of the COPII coat of vesicles involved in endoplasmic reticulum to Golgi transport, member of the ADP-ribosylation factor (ARF) family, which are GTP-binding proteins GTP-binding protein ZK180.5 ZK180.5 Protein of unknown function, has weak similarity to human transmembrane mucin 1, MUC1 ZK180.6 ZK180.6 Protein with weak similarity to C. elegans Y49E10.X ZK185.1 ZK185.1 Protein of unknown function, has low similarity to uncharacterized C. elegans F21G4.5 ZK185.2 ZK185.2 Member of the divalent cation transporter family, which may transport Mg2+ or other divalent cations into the cell, has moderate similarity to uncharacterized C. elegans K07H8.2 ZK185.3 ZK185.3 Protein of unknown function ZK20.1 ZK20.1 Protein of unknown function ZK20.3 ZK20.3 Member of the ubiquitin family, contains two UBA (ubiquitin associated) or TS-N domains, has moderate similarity to RAD23 homolog B (human RAD23B), which binds human XPC to form a global genome nucleotide excision repair DNA damage recognition protein RAD23 protein homolog2 like ZK20.4 ZK20.4 Protein of unknown function ZK20.5 rpn-12;ZK20.5 Protein with low similarity to S. cerevisiae Rpn12p, which is a non-ATPase component of 26S proteasome complex that is required for activation of S. cerevisiae Cdc28p protein kinase and functions in RNA polymerase II transcription elongation vegetative protein X like; rpn-12 is predicted to encode a non-ATPase subunit of the 19S regulatory complex of the proteasome that interacts with NHR-6 in yeast two-hybrid assays. ZK20.6 ZK20.6 Member of the M13 peptidase family of zinc metalloproteases, has moderate similarity to endothelin-converting enzyme 1 (human ECE1), which is a zinc metalloprotease that generates endothelin vasoconstrictors and is associated with developmental defects neprilysin; ZK20.6 encodes a neprilysin; neprilysins are thermolysin-like zinc metallopeptidases, found on the outer surface of animal cells, that negatively regulate small signalling peptides (e.g., enkephalin, tachykinin, insulin, and natriuretic peptides) by cleaving them; ZK20.6 is closely paralogous to F18A12.8, and orthologous to CG9761 in Drosophila melanogaster; more generally, ZK20.6 falls into a group of proteins that includes the classical neprilysins found in mammals (e.g., PEX [OMIM:307800] and the enkephalin cleaving enzymes). ZK218.1 ZK218.1 Protein containing a DUF18 domain of unknown function, has high similarity to uncharacterized C. elegans ZK218.3 ZK218.11 ZK218.11 Protein containing a DUF18 domain of unknown function, has high similarity to uncharacterized C. elegans ZK218.7 ZK218.2 ZK218.2 Member of the Tc3 Transposase protein family transposase ZK218.3 ZK218.3 Protein containing a DUF18 domain of unknown function, has high similarity to uncharacterized C. elegans ZK218.7 ZK218.4 ZK218.4 Protein containing a DUF216 domain of unknown function, has high similarity to uncharacterized C. elegans ZC132.9 ZK218.5 ZK218.5 Protein containing a DUF18 domain of unknown function, has high similarity to uncharacterized C. elegans ZK218.3 ZK218.6 ZK218.6 Protein containing nuclear hormone receptor C4-type zinc finger and ligand-binding domains, has weak similarity to human RXRG, which is a putative retinoic acid receptor involved in transcriptional activation Zinc finger, C4 type (two domains) ZK218.7 ZK218.7 Protein containing a DUF18 domain of unknown function, has high similarity to uncharacterized C. elegans ZK218.3 ZK218.8 ZK218.8 Protein containing a piwi domain, has a region of high similarity to a region of C. elegans RDE-1, which is a protein involved in the mechanism of RNA-mediated gene silencing ZK228.1 ZK228.1 Protein of unknown function, has low similarity to uncharacterized C. elegans ZC15.1 ZK228.2 ZK228.2 Member of the reverse transcriptase protein family, which are RNA-dependent DNA polymerases, contains a retroviral integrase core domain, which can act as endonucleases, has high similarity to uncharacterized C. elegans Y43F4A.2 Reverse transcriptase (RNA-dependent DNA polymerase) ZK228.3 ZK228.3 Member of an uncharacterized protein family ZK228.4 ZK228.4 Protein of unknown function, has high similarity to uncharacterized C. elegans ZK228.3 ZK228.5 ZK228.5 Member of the 7-transmembrane chemoreceptor family of G-protein coupled receptors (GPCR), has high similarity to uncharacterized C. elegans ZK228.6 ZK228.6 ZK228.6 Member of the 7-transmembrane chemoreceptor family of G-protein coupled receptors (GPCR), has high similarity to uncharacterized C. elegans ZK228.5 ZK228.7 ZK228.7 Member of the 7-transmembrane chemoreceptor family of G-protein coupled receptors (GPCR), has high similarity to uncharacterized C. elegans ZK228.8 ZK228.8 ZK228.8 Member of the 7-transmembrane chemoreceptor family of G-protein coupled receptors (GPCR), has high similarity to uncharacterized C. elegans ZK228.7 ZK250.1 ZK250.1 Member of the reverse transcriptase protein family, which are RNA-dependent DNA polymerases, has moderate similarity to uncharacterized C. elegans F38E9.3 reverse transcriptase ZK250.10 ZK250.10 Putative paralog of C. elegans ZK250.9, has weak similarity at the C-terminus of S. cerevisiae PIF1, mitochondrial DNA repair and recombination protein ZK250.2 ZK250.2 Protein containing a DUF130 domain of unknown function, has strong similarity to uncharacterized C. elegans C52E2.3 ZK250.3 ZK250.3 Member of the reverse transcriptase protein family, which are RNA-dependent DNA polymerases, has high similarity to uncharacterized C. elegans ZK1236.4 reverse trascriptase ZK250.4 ZK250.4 TcA transposase transposase ZK250.5 ZK250.5 Protein containing two meprin and TRAF homology (MATH) domains, two DUF38 domains of unknown function, and an F-box domain, which link a target protein with a ubiquitin-conjugating enzyme, has high similarity to uncharacterized C. elegans T08E11.1 This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins; this gene's encoded protein also contains an FTH/DUF38 motif, which may also mediate protein-protein interaction. ZK250.6 ZK250.6 Protein containing four meprin and TRAF homology (MATH) domains ZK250.7 ZK250.7 Protein containing three meprin and TRAF homology (MATH) domains, has high similarity to uncharacterized C. elegans C16C4.13 ZK250.8 ZK250.8 Protein containing three meprin and TRAF homology (MATH) domains, has strong similarity to uncharacterized C. elegans C40D2.2 The ZK250.8 gene encodes a protein closely similar to C46F9.3, which has a meprin-associated Traf homology (MATH) domain and may be involved in apoptosis. ZK256.1 pmr-1;ZK256.1 Ca2+-transporting P-type ATPase of Golgi membrane E1-E2 ATPases; The pmr-1 gene encodes a Golgi P-type ATPase Ca^2+/Mn^2+-pump; mutations in its human ortholog, ATP2C1, cause Hailey-Hailey disease (OMIM:169600). ZK262.1 ZK262.1 Member of the 7-transmembrane chemoreceptor family of G-protein coupled receptors (GPCR), has high similarity to uncharacterized C. elegans ZK262.11 ZK262.10 ZK262.10 Member of the 7-transmembrane chemoreceptor family of G-protein coupled receptors (GPCR), has high similarity to uncharacterized C. elegans T01G5.3 ZK262.11 ZK262.11 Member of the 7-transmembrane chemoreceptor family of G-protein coupled receptors (GPCR), has high similarity to uncharacterized C. elegans ZK262.1 ZK262.2 ZK262.2 Member of the lipase class 3 family, which are a subset of lipolytic enzymes that hydrolyze ester linkages of triglycerides, has strong similarity to uncharacterized C. elegans ZK262.3 ZK262.3 ZK262.3 Member of the lipase class 3 family, which are a subset of lipolytic enzymes that hydrolyze ester linkages of triglycerides, has strong similarity to uncharacterized C. elegans ZK262.2 ZK262.4 ZK262.4 Protein of unknown function, has weak similarity to C. elegans Y51A2B.6 ZK262.5 ZK262.5 Member of the Tc3 Transposase protein family ZK262.6 ZK262.6 G protein-coupled receptor of unknown function, no homolog found in human or D. melanogaster 7TM chemoreceptor, srw family ZK262.7 ZK262.7 Protein with similarity over the N-terminal region to members of the G protein-coupled receptor family, no homolog found in human or D. melanogaster 7TM chemoreceptor, srw family ZK262.8 ZK262.8 Putative ortholog of C. elegans C03A7.2 gene product ZK262.9 ZK262.9 Protein of unknown function, has weak similarity to C. elegans Y43F4A.3 ZK265.1 ZK265.1 Protein containing three ankyrin (Ank) repeats, has a region of moderate similarity to a region of BRCA1 associated RING domain 1 (mouse Bard1), which binds mouse Brca1 and may participate in tumor suppression Human G9A protein like ZK265.2 ZK265.2 Protein containing two collagen triple helix repeats and one nematode cuticle collagen N-terminal domain, has moderate similarity to a region of C. elegans BLI-1, which is a putative collagen collagen ZK265.3 ZK265.3 Member of a protein family ZK265.4 ceh-8;ZK265.4 Homeodomain transcription factor, has similarity over the homeodomain to many human and D. melanogaster homeodomain transcription factors homeobox protein (otd subfamily); ceh-8 encodes a paired-like homeodomain protein of the Q50 class orthologous to the Rx homeobox protein of humans (RAX; OMIM:601881) and Drosophila (CG10052-PA); CEH-8 and RX belong to one of at least 18 distinct families of paired-like homeodomain proteins, including 12 families in the Q50 class. ZK265.5 ZK265.5 Member of the C. elegans Sre G protein-coupled chemoreceptor family, which are putative chemosensory receptors 7TM receptor, sre family ZK265.6 ZK265.6 Protein of unknown function ZK265.7 ZK265.7 Protein of unknown function, predicted to contain a glycosylphosphatidylinositol (GPI) lipid anchor ZK265.8 ZK265.8 Protein of unknown function, has a region of low similarity to a region of C. elegans CUT-1, which is a cuticulin component cuticulin ZK270.1 ptr-23;ZK270.1 Member of the patched family, which are transmembrane receptors, has weak similarity to human NPC1, which is a lysosomal protein that plays a role cholesterol transport and is associated with Niemann-Pick type C1 disease ZK270.2 ZK270.2 Protein containing six FERM domains (Band 4.1 family), which link cytoplasmic proteins to membranes, has a region of low similarity to a region of mouse Epb4.1l1 Band 4.1 protein like ZK285.1 ZK285.1 Member of the 7-transmembrane chemoreceptor family of G-protein coupled receptors (GPCR), has low similarity to a region of C. elegans ODR-10, which is a G protein-coupled receptor involved in odorant response ZK287.1 ZK287.1 Protein with weak similarity to C. elegans B0244.8 ZK287.2 ZK287.2 Putative sulfate transporter, has strong similarity to human DTD protein (sulfate transporter involved in diastrophic dysplasia) sulphate permease ZK287.3 ZK287.3 Protein of unknown function ZK287.4 ZK287.4 Protein containing seven kunitz or bovine pancreatic trypsin inhibitor domains, has a region of moderate similarity to a region of alpha-1-microglobulin and bikunin precursor (human AMBP), which is a lipocalin transport protein serine protease inhibitor ZK287.5 rbx-1;ZK287.5 Protein with high similarity to ring box 1 (human RBX)1, which is a component of the von Hippel Lindau tumor suppressor complex and of SCF ubiquitin ligase, functions in ubiquitin polymerization and ubiquitin-dependent protein degradation Zinc finger, C3HC4 type (RING finger); The rbx-1 gene encodes an ortholog of the mammalian RING box protein RBX1 (or ROC1), which interacts with several cullins and is a subunit of both the von Hippel-Lindau (VHL) tumor suppressor complex and of the SCF ubiquitin-ligase (E3) complex. ZK287.6 ZK287.6 Protein containing four C2H2 type zinc finger domains, which bind nucleic acids Zinc finger, C2H2 type (3 domains) ZK287.7 ZK287.7 Protein of unknown function ZK287.8 her-1;ZK287.8 Secreted factor that acts to promote male development HER-1 protein; The autosomal gene her-1 is repressed by SDC-2 to elicit hermaphrodite differentiation; SDC-2 also represses transcription of X chromosomes to achieve dosage compensation. ZK328.1 uch-1;UCH;UBP130;ZK328.1 Ubiquitin C-terminal hydrolase ubiquitin conjugating enzyme; recoverin subfamily of EF-hand calcium binding protein; cyk-3 encodes a functional ubiquitin C-terminal hydrolase required for embryonic viability and for cellular osmotic regulation; osmotic regulation defects in mutants contribute at least partially to cytokinesis defects in mutant embryos. ZK328.2 eft-1;ZK328.2 Protein with high similarity to U5 snRNP-specific protein 116 kDa (human U5-116KD), which is a spliceosome component with GTPAse activity, contains elongation factor Tu GTP binding and domain 2 domains, and an elongation factor G C-terminal domain elongation factor 2 ZK328.4 ZK328.4 Protein of unknown function, has weak similarity to uncharacterized human NAAR1 ZK328.5 ZK328.5 Protein with low similarity to nucleoporin 98 kD (human NUP98), which is a nuclear pore complex (NPC) protein that localizes to the nucleoplasmic side of NPC and perinucleolar region, interacts with human TPR, and may be associated with myeloid leukemia nucleoporin; npp-10 is orthologous to the human gene NUCLEOPORIN, 98-KD (NUP98; OMIM:601021), which can promote leukemias (myelodysplastic syndromes, AML, or CML) when chromosomally rearranged. ZK328.6 tbx-7;ZK328.6 Putative DNA-binding protein, member of the T-box protein family ZK328.7 ZK328.7 Protein containing seven TPR (tetratrico peptide repeat) domains, which may mediate protein-protein interactions stress-inducible protein STI1 ZK328.8 ZK328.8 Putative ortholog of C. elegans tbx-2 gene product This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins. ZK337.1 ZK337.1 Putative ortholog of H. sapiens A2M, an alpha-2-macroglobulin Alpha-2-macroglobulin family (3 domains) ZK337.2 ZK337.2 Protein containing four C2H2 type zinc finger domains, which bind nucleic acids, has a region of moderate similarity to a region of early growth response 1 (mouse Egr1), which a zinc finger transcription factor that functions in conjunction with c-fos Zinc finger, C2H2 type (4 domains) ZK337.4 ZK337.4 Protein with weak similarity to S. cerevisiae RAD9 (DNA repair checkpoint protein required for cell cycle arrest following DNA damage) ZK337.5 ZK337.5 Protein of unknown function mtd-1 encodes a novel protein, with an N-terminal extracellular domain and a C-terminal transmembrane domain, that is expressed in touch receptor neurons; loss of mtd-1 function (by either RNAi or a deletion mutation) has no obvious phenotype alone, but specifically enhances touch insensitivity of the temperature-sensitive mec-6(u247). ZK353.1 ZK353.1 Protein containing two cyclin N-terminal domains ZK353.2 ZK353.2 Protein of unknown function, has weak similarity to C. elegans Y41C4A.13 ZK353.3 ZK353.3 Protein of unknown function ZK353.4 ZK353.4 Protein of unknown function, has weak similarity to C. elegans ZK783.1 ZK353.5 ZK353.5 Protein of unknown function ZK353.6 lap-1;ZK353.6 Leucine aminopeptidase; member of the cytosol aminopeptidase protein family Leucine aminopeptidase; The lap-1 gene encodes a homolog of the zinc metalloprotease leucine aminopeptidase LAP that is predicted to be mitochondrial. ZK353.7 ZK353.7 Protein of unknown function, has moderate similarity to uncharacterized human LOC51076 ZK353.8 ZK353.8 Protein containing a UBX domain, which are found in ubiquitin regulatory proteins, has low similarity to uncharacterized human UBXD2 ZK353.9 ZK353.9 Putative paralog of C. elegans ZK353.1 ZK354.1 msp-65;ZK354.1 Major sperm protein required for spermatogenesis in C. elegans major sperm protein (MSP-65); msp-65 encodes a protein that belongs to a family of proteins called the Major Sperm Proteins (MSPs) that is conserved in nematodes; this family consists of closely related, small, basic proteins that make up 15% of sperm protein; this multigene family consists of over fifty genes, including many pseudogenes; MSPs are involved in both extracellular signaling and cytoskeletal functions during reproduction-MSP antagonizes Eph/ephrin signaling, in part, by binding VAB-1 Eph receptor tyrosine kinase on oocytes and sheath cells to promote oocyte maturation and MAPK activation; MSPs assemble into fibrous networks that drive movement of the C. elegans sperm; msp genes are expressed only in late primary spermatocytes. ZK354.11 msp-59;ZK354.11 Sperm-specific protein involved in sperm motility, member of the major sperm protein (MSP) family major sperm protein (MSP-59); msp-59 encodes a member of the major sperm protein family. ZK354.2 ZK354.2 Protein containing two protein kinase domains, has low similarity to casein kinase 1 gamma 1 (rat Csnk1g1), which is a serine/threonine protein kinase that may play roles in cell growth and in morphogenesis protein kinase ZK354.3 ZK354.3 Protein of unknown function, has high similarity to uncharacterized C. elegans C17F3.3 ZK354.4 msp-113;ZK354.4 Member of major sperm protein family major sperm protein (MSP-113); msp-113 encodes a protein that belongs to a family of proteins called the Major Sperm Proteins (MSPs) that is conserved in nematodes; msp-113 has a C. briggsae homolog as detected by the Wobble Aware Bulk Aligner (WABA); the MSP family consists of closely related, small, basic proteins that make up 15% of sperm protein; this multigene family consists of over fifty genes, including many pseudogenes; the msp-113 promoter region contains two conserved cis elements that are recognition sites for elt-1, a gene that encodes a homolog of the vertebrate GATA transcription factor family; this suggests that a MSP protein is a potential target for ELT-1 in the germ-line; MSPs are involved in both extracellular signaling and cytoskeletal functions during reproduction-MSP antagonizes Eph/ephrin signaling, in part, by binding VAB-1 Eph receptor tyrosine kinase on oocytes and sheath cells to promote oocyte maturation and MAPK activation; MSPs assemble into fibrous networks that drive movement of the C. elegans sperm; msp genes are expressed only in late primary spermatocytes. ZK354.5 msp-51;ZK354.5 Major sperm protein required for spermatogenesis in C. elegans major sperm protein (MSP-51); msp-51 encodes a protein that belongs to a family of proteins called the Major Sperm Proteins (MSPs) that is conserved in nematodes; this family consists of closely related, small, basic proteins that make up 15% of sperm protein; this multigene family consists of over fifty genes, including many pseudogenes; MSPs are involved in both extracellular signaling and cytoskeletal functions during reproduction-MSP antagonizes Eph/ephrin signaling, in part, by binding VAB-1 Eph receptor tyrosine kinase on oocytes and sheath cells to promote oocyte maturation and MAPK activation; MSPs assemble into fibrous networks that drive movement of the C. elegans sperm; msp genes are expressed only in late primary spermatocytes. ZK354.6 ZK354.6 Protein containing a protein kinase domain, has low similarity to casein kinase 1 alpha 1 (human CSNK1A1), which is a serine/threonine protein kinase that may play a role in Alzheimer's disease protein kinase ZK354.7 ZK354.7 Protein containing a major sperm protein (MSP) domain, which are involved in sperm motility, has high similarity to uncharacterized C. elegans K05F1.9 ZK354.8 ZK354.8 Member of the protein-tyrosine phosphatase family, which are involved in control of cell growth, proliferation, differentiation and transformation, has a region of low similarity to C. elegans F10G8.1, which is a putative tyrosine protein phosphatase protein phosphatase ZK354.9 ZK354.9 Protein with high similarity to C. elegans W09C3.6, which is a phosphatase involved in cell growth and maintenance, member of the serine or threonine protein phosphatase family protein phosphatase ZK355.1 ZK355.1 Protein of unknown function, putative paralog of C. elegans F45C12.16 ZK355.2 ZK355.2 Protein of unknown function ZK355.3 ZK355.3 Protein of unknown function ZK355.4 ZK355.4 Protein of unknown function, putative paralog of C. elegans ZK355.5 ZK355.5 ZK355.5 Protein of unknown function, putative paralog of C. elegans T11F1.8 ZK355.6 ZK355.6 Protein of unknown function, putative paralog of C. elegans T11F1.2 ZK370.2 sma-2;cem-1;PAR2.2;ZK370.2 Smad protein similar to vertebrate Smad1, involved in transduction of signal from a TGF-beta-like receptor ZK370.3 ZK370.3 Protein containing two I or LWEQ domains and two epsin N-terminal homology (ENTH) domains, has low similarity to huntingtin interacting protein 1 related protein (mouse Hip1r), which binds F-actin and clathrin, may link clathrin-coated vesicles to actin Talin ZK370.4 ZK370.4 Member of the cyclic nucleotide-binding domain protein family ZK370.5 ZK370.5 Protein with high similarity to pyruvate dehydrogenase kinase 2 (rat Pdk2), which phosphorylates and inactivates the pyruvate dehydrogenase complex and thus putatively regulates pyruvate metabolism, contains a histidine kinase-like ATPase domain Phosphoprotein ZK370.6 ZK370.6 Protein of unknown function ZK370.7 ZK370.7 Protein containing an uncharacterized domain DUF6, has moderate similarity to solute carrier family 35 member 1 (mouse Slc35a1), which is a Golgi CMP-sialic acid transporter that is important for normal sialylation of glycoproteins and glycolipids ZK370.8 ZK370.8 Protein containing two TPR (tetratrico peptide repeat) domains, which may mediate protein-protein interactions ZK377.1 wrt-6;ZK377.1 Protein of unknown function, contains warthog domain and hedgehog domain/hint module ZK377.3 sax-3;ZK377.2;ZK377.3 Predicted transmembrane protein involved in axon guidance of motor neurons both to and within the ventral nerve cord; member of the Immunoglobin superfamily ZK380.1 ZK380.1 Protein containing a T-box domain, which bind DNA DNA-binding protein ZK380.2 ZK380.2 Protein with moderate similarity to C. elegans K02H11.6, has weak similarity to human GOLGB1, a Golgi complex outher membrane protein ZK380.4 ZK380.4 Protein of unknown function, has high similarity to uncharacterized C. elegans C55A1.9 ZK381.1 him-3;ZK381.1 Meiosis-specific protein localized to chromosome cores; may play a role in sister chromatid cohesion him-3 encodes a homolog of the S. cerevisiae HOP1 protein which is required for the formation of the synaptonemal complex during meiosis; him-3 is required for synapsis and chiasma formation during meiotic recombination and for chromosome segregation; him-3 mutants show a high frequency of males in the population as well as a high frequency of arrested embryos due to defects in X-chromosome segregation; HIM-3 localizes to the meiotic chromosome associating with both unsynapsed and synapsed chromosomes. ZK381.2 ZK381.2 Protein containing a DUF23 domain of unknown function, has strong similarity to uncharacterized C. elegans C49A1.5 ZK381.3 ZK381.3 Protein containing a nuclear hormone receptor ligand-binding domain, has moderate similarity to uncharacterized C. elegans ZK1025.6 ZK381.4 pgl-1;ZK381.4 Component of P granules; binds RNA pgl-1 encodes a predicted RNA-binding protein that contains a number of C-terminal RGG box motifs; PGL-1 activity is required at high temperatures during midlarval to adult stages for postembryonic germline development and hence fertility, and also for proper formation of the germline-specific P granules; PGL-1 protein, supplied maternally and embryonically, is a constitutive P granule component and thus, its localization is cytoplasmic in oocytes and early embryos, while perinuclear in the germline blastomere P4 and proliferating germ cells of larvae and adults; pgl-1 mRNA is expressed exclusively in hermaphrodite and male germlines and is detectable at all stages of development, with highest levels seen in adults; PGL-1 localization to P granules requires wild-type activity of the predicted germline helicase GLH-1. ZK381.5 ZK381.5 Protein containing two LIM domains, which may mediate protein-protein interactions, has a region of low similarity to a region of four and a half LIM domains 1 (mouse Fhl1), which is a negative regulatory molecule for mouse Rbpsuh -mediated transcription ZK381.6 ZK381.6 Protein containing one LIM domain, which may mediate protein-protein interactions ZK384.1 ZK384.1 Member of the SCP-like extracellular protein family, has low similarity to uncharacterized C. elegans ZK384.2 SCP-like extracellular Proteins ZK384.2 ZK384.2 Member of the SCP-like extracellular protein family, has low similarity to a region of protease inhibitor 15 (human PI15), which is a trypsin inhibitor involved in the regulation of extracellular matrix proteolysis that contributes to tumor invasion SCP-like extracellular Proteins (2 domains) ZK384.3 ZK384.3 Member of the aspartyl (acid) protease family, which include pepsins, cathepsins, and renins, has a region of high similarity to C. elegans ASP-1, which is a putative aspartyl protease Eukaryotic aspartyl proteases ZK39.2 ZK39.2 Protein containing a C-type lectin domain, which mediate calcium-dependent carbohydrate recognition, has high similarity to uncharacterized C. elegans T26E3.1 Lectin C-type domain ZK39.3 ZK39.3 Protein containing a C-type lectin domain, which mediate calcium-dependent carbohydrate recognition, has high similarity to uncharacterized C. elegans ZK39.4 Lectin C-type domain ZK39.4 ZK39.4 Protein containing a C-type lectin domain, which mediate calcium-dependent carbohydrate recognition, has high similarity to uncharacterized C. elegans ZK39.3 ZK39.5 ZK39.5 Member of the C-type lectin family Lectin C-type domain short and long forms ZK39.6 ZK39.6 Member of the C-type lectin family, has weak similarity to human versican chondroitin sulfate proteoglycan ZK39.7 ZK39.7 Member of the C-type lectin family, has weak similarity to human neurocan and versican chondroitin sulfate proteoglycans Lectin C-type domain short and long forms ZK39.8 ZK39.8 Protein containing a C-type lectin domain, which mediate calcium-dependent carbohydrate recognition, has high similarity to uncharacterized C. elegans ZK39.7 Lectin C-type domain ZK40.1 ZK40.1 Member of the phospholipid and glycerol acyltransferase family, which are involved in phospholipid biosynthesis, has moderate similarity to uncharacterized C. elegans T05H4.1 ZK40.2 ZK40.2 Putative ortholog of C. elegans unc-83 gene product ZK402.1 ZK402.1 Putative ortholog of C. elegans ZK402.5 gene product ZK402.2 ZK402.2 Protein with strong similarity to C. elegans ZK402.5 gene product ZK402.3 ZK402.3 Protein with strong similarity to C. elegans ZK402.5 gene product ZK402.4 ZK402.4 Protein of unknown function ZK402.5 ZK402.5 Protein of unknown function, has moderate similarity to uncharacterized C. elegans T28A8.6 ZK418.1 nhr-9;ZK418.1 Protein containing nuclear hormone receptor C4-type zinc finger and ligand-binding domains, has low similarity to C. elegans NHR-51, which is involved in developmental processes ZK418.2 ZK418.2 Protein of unknown function ZK418.3 ZK418.3 Protein of unknown function ZK418.4 lin-37;ZK418.4 Part of the class B pathway that antagonizes vulval induction ZK418.5 ZK418.5 Putative transmembrane protein with similarity to human NIFIE14, putative seven transmembrane domain protein ZK418.6 ZK418.6 Member of the rhodopsin family of G protein-coupled receptors (GPCR) ZK418.7 ZK418.7 Member of the rhodopsin family of G protein-coupled receptors (GPCR), has weak similarity to uncharacterized C. elegans B0244.7 ZK418.8 ZK418.8 Protein containing two KH domains, which may bind RNA possible RNA binding protein ZK418.9 ZK418.9 Protein with similarity to a family of single-strand DNA-binding proteins possible RNA binding protein; ZK418.9 encodes two proteins by alternative splicing, belonging to an ancient family of single-stranded nucleic acid-binding proteins, that are predicted to regulate gene expression through binding either mRNA or (locally) single-stranded DNA; they are most likely to specifically bind one or more discrete mRNAs and regulate their spatial localization or alternative splicing. ZK430.1 ZK430.1 Protein of unknown function ZK430.2 ZK430.2 Member of the inositol monophosphatase family, which participate in the inositol phosphate second messenger signaling pathway, has moderate similarity to 3'(2') 5'-bisphosphate nucleotidase 1 (human BPNT1), which plays a role in nucleotide metabolism ammonium transport protein; This gene encodes a protein predicted by Eisenberg and coworkers, with 52% accuracy, to be mitochondrial. ZK430.3 ZK430.3 Protein with high similarity to superoxide dismutase (C. elegans SOD-1), which appears to control a determinant of aging, member of the copper-zinc superoxide dismutase family, which convert superoxide into molecular oxygen and hydrogen peroxide superoxide dismutase ZK430.5 ZK430.5 Protein with high similarity to C. elegans SEP-1, which is required for chromosome segregation during meiosis I ZK430.7 ZK430.7 Protein containing WD repeats, putative ortholog of S. cerevisiae Sof1p, a protein involved in rRNA processing ribosomal processing protein ZK430.8 ZK430.8 Member of the animal heme peroxidase family, which catalyze biosynthetic and degradative reactions using hydrogen peroxide as the electron acceptor, has low similarity to eosinophil peroxidase (mouse Epx), which functions in reactive oxidant production peroxidase ZK455.1 ZK455.1 Protein with high similarity to mouse Aco1, which catalyzes citrate-isocitrate interconversion and binds iron-responsive elements to regulate iron homeostasis, member of the aconitate hydratase family, contains an aconitase C-terminal domain iron-responsive element-binding like protein; aco-1 encodes an aconitase that is dispensable for embryonic development in RNAi assays, that is homologous to mammalian iron regulatory protein-1 (IRP1), and that physically interacts with GEX-3; like IRP1, ACO-1 has aconitase activity and is post-translationally regulated by iron, but, unlike IRP1, it lacks RNA-binding activity; ACO-1 is predicted to be mitochondrial. ZK455.2 gcy-9;ZK455.2 Putative guanylyl cyclase guanylate cyclase ZK455.3 ZK455.3 Member of the rhodopsin family of G protein-coupled receptors (GPCR), has low similarity to galanin receptor 2 (rat Galr2), which is involved in pain perception and jejunal smooth muscle contraction and may regulate pituitary hormone secretion G-protein coupled receptor ZK455.4 asm-2;ZK455.4 Acid sphingomyelinase sphingomyelin phosphodiesterase; asm-2 encodes an ortholog of human SPHINGOMYELIN PHOSPHODIESTERASE 1, ACID LYSOSOMAL (SMPD1; OMIM:607608), which when mutated leads to Niemann-Pick disease type B. ZK455.5 ZK455.5 Protein with strong similarity to C. elegans Y48E1B.8 gene product ZK455.6 ZK455.6 Protein containing a nuclear hormone receptor ligand-binding domain and a nuclear hormone receptor C4-type zinc finger domain, which bind DNA and may be involved in regulation of transcription, has weak similarity to C. elegans NHR-80 Zinc finger, C4 type (two domains) ZK455.7 pgp-3;ZK455.7 P-glycoprotein of intestinal cells, multidrug resistance protein of the ATP-binding cassette (ABC) superfamily, has strong similarity to human, Drosophila, and S. cerevisiae multidrug resistance proteins multidrug resistance protein 3 (p-glycoprotein C); pgp-3 encodes a transmembrane protein that is a member of the P-glycoprotein subclass of the ATP-binding cassette (ABC) transporter superfamily; with PGP-1, PGP-3 is required for defense against the pathogenic Pseudomonas aeruginosa strain PA14, and may facilitate ATP-dependent efflux of the toxic phenazine compounds produced by the bacteria; PGP-3 is also required for resistance to colchicine and chloroquine; PGP-3 is expressed in the apical membranes of the excretory cell and the intestinal cells; loss of pgp-3 activity via large-scale RNAi screens does not result in any obvious abnormalities. ZK455.8 ZK455.8 Member of the sugar (and other) transporter family, has low similarity to human SLC22A5, which is a sodium-dependent carnitine transporter that provides carnitine for fatty acid beta-oxidation membrane transporter ZK470.1 ZK470.1 Protein of unknown function ZK470.2 ZK470.2 Protein of unknown function ZK470.3 ZK470.3 Protein of unknown function ZK470.4 ZK470.4 Protein of unknown function ZK470.5 ZK470.5 Protein containing five Src homology 3 (SH3) domains, which bind proline-rich peptides, and two Src homology 2 (SH2) domain, which are regulatory modules, has moderate similarity to non-catalytic region of tyrosine kinase adaptor protein 2 (mouse Nck2) SH2-, SH3-, containing protein; tag-22 encodes a protein with similarity to the human NCK adaptor protein 2 and orthologous to C. ZK470.6 ZK470.6 Protein with moderate similarity to C. elegans F42A10.6 gene product ZK484.1 ZK484.1 Member of the ornithine decarboxylase antizyme family, which bind to and destabilize ornithine decarboxylase ZK484.2 ZK484.2 Member of the ABC transporter family, contains an ABC transporter transmembrane domain, has moderate similarity to transporter associated with antigen processing 2 (rat Tap2), which mediates delivery of peptides to the endoplasmic reticulum transporter protein; haf-9 is orthologous to the human gene ATP-BINDING CASSETTE, SUB-FAMILY B (MDR/TAP), MEMBER 3 (TAP2; OMIM:170261), which when mutated leads to disease. ZK484.3 ZK484.3 Protein of unknown function ZK484.4 ZK484.4 Protein of unknown function ZK484.5 ZK484.5 Protein of unknown function ZK484.6 ZK484.6 Member of the phosphoglycerate mutase family, has low similarity to uncharacterized C. elegans Y18H1A.4 ZK484.7 ZK484.7 Protein with high similarity to C. elegans F10G8.1, which is a putative tyrosine protein phosphatase involved in embryogenesis and morphogenesis, member of the protein-tyrosine phosphatase family protein tyrosine phosphatase ZK484.8 ZK484.8 Protein of unknown function ZK488.1 ZK488.1 Protein containing a nuclear hormone receptor C4-type zinc finger domain, has low similarity to C. elegans NHR-58, which is involved in developmental processes zinc finger protein ZK488.10 ZK488.10 Protein containing a DUF148 domain of unknown function, has strong similarity to uncharacterized C. elegans ZK488.7 The protein product of this gene is predicted to contain a glutamine/asparagine (Q/N)-rich ('prion') domain, by the algorithm of Michelitsch and Weissman (as of the WS77 release of WormBase, i.e., in wormpep77). ZK488.2 nhr-90;ZK488.2 Protein with high similarity to C. elegans NHR-58, which is a putative nuclear hormone receptor-Zinc finger protein that is involved in embryogenesis and morphogenesis, contains a nuclear hormone receptor ligand-binding and C4-type zinc finger domains zinc finger protein ZK488.4 ZK488.4 Protein containing a nuclear hormone receptor ligand-binding domain and a nuclear hormone receptor C4-type zinc finger domain, which bind DNA and may be involved in regulation of transcription, has high similarity to uncharacterized C. elegans C14C6.4 zinc finger protein ZK488.5 ZK488.5 Protein containing a DUF138 domain of unknown function, has high similarity to uncharacterized C. elegans ZK488.6 ZK488.6 ZK488.6 Protein containing a DUF138 domain of unknown function, has high similarity to uncharacterized C. elegans ZK488.5 ZK488.7 ZK488.7 Protein containing a DUF148 domain of unknown function, has strong similarity to uncharacterized C. elegans ZK488.10 The protein product of this gene is predicted to contain a glutamine/asparagine (Q/N)-rich ('prion') domain, by the algorithm of Michelitsch and Weissman (as of the WS77 release of WormBase, i.e., in wormpep77). ZK488.8 ZK488.8 Protein of unknown function, has high similarity to uncharacterized C. elegans R11G11.13 ZK488.9 ZK488.9 Protein of unknown function, has high similarity to uncharacterized C. elegans R11G11.13 7TM chemoreceptor, srw family ZK507.1 ZK507.1 Protein containing a protein kinase domain, has a region of moderate similarity to a region of S. pombe Cki3p, which is a putative casein kinase involved in developmental processes serine/threonine kinase ZK507.3 ZK507.3 Protein containing a protein kinase domain, hAS high similarity to uncharacterized C. elegans ZK507.1 Protein kinase domain ZK507.4 ZK507.4 Protein of unknown function, has weak similarity to C. elegans T05D4.4 ZK507.6 ZK507.6 Protein containing cyclin N-terminal and C-terminal domains, which form complexes with protein kinases and cyclin dependent protein kinases (CDI), has weak similarity to S. pombe Cdc13p, which is a cyclin that promotes entry into mitosis from G2 phase G2/M Cyclin A ZK512.1 ZK512.1 Protein of unknown function ZK512.2 ZK512.2 Member of the DEAD or DEAH box ATP-dependent RNA helicase family and contains a helicase conserved C-terminal domain, has low similarity to S. cerevisiae Spb4p, which is required for processing of 25S ribosomal RNA precursor RNA helicase ZK512.3 ced-11;ltrpc4;ZK512.3 Protein of unknown function, has a region of weak similarity to a region of transient receptor potential channel subfamily M member 7 (human TRPM7), which is a channel that is activated by intracellular ATP and permeable to calcium and magnesium The ced-11 gene encodes a predicted transmembrane ion channel related to the long transient receptor potential channel (LTRPC) subfamily of TRP channels found in Drosophila and mammals; CED-11 functions as a downstream effector in the programmed cell death pathway and may play a role in affecting the morphological changes seen in the nucleus, cytoplasm, and plasma membrane of apoptotic cells. ZK512.4 ZK512.4 Protein with high similarity to signal recognition particle 9 kDa (mouse Srp9), which is a subunit of the signal recognition particle that binds to Alu RNA and signal recognition particle RNA with Srp14 and aids protein transport across the ER membrane Signal Recognition Particle 9Kd protein ZK512.5 ZK512.5 Protein of unknown function, has weak similarity to uncharacterized mouse Rgpr ZK512.6 eat-4;not-1;ZK512.6 Putative Na+/Pi-cotransporter with similarity to mammalian brain-specific BNPI, member of the major facilitator superfamily Sodium/phosphate cotransporter; eat-4 encodes an ortholog of the mammalian BNPI vesicular glutamate transporter that affects chemotaxis, feeding, foraging and thermotaxis; eat-4 is expressed in specific neurons, including M3L and M3R which are known to be glutamatergic. ZK512.7 ZK512.7 Protein of unknown function, has high similarity to uncharacterized C. elegans F43C11.3 ZK512.8 ZK512.8 Protein of unknown function, has high similarity to uncharacterized C. elegans ZC412.5 ZK512.9 ZK512.9 Protein of unknown function containing a Ground-like domain ZK520.1 ZK520.1 Protein of unknown function, has weak similarity to human protein KIAA0590 (Hs.111862) ZK520.2 ZK520.2 Protein of unknown function ZK520.3 ZK520.3 Protein with weak similarity to C. elegans C36B1.5, which is a putative U4/U6 snRNP-associated splicing factor and member of the WD repeat protein family ZK520.4 cul-2;ZK520.4 Member of the cullin family of cell cycle control proteins Cullin family (2 domains); cul-2 encodes a member of the cullin family that affects embryonic viability and is required for cytokinesis and mitotic chromosome segregation; expressed embryonically in diverse cell types throughout larval development and in the adult germ line. ZK520.5 cyp-2;cyp-7;ZK520.5 Cyclophilin-related peptidylprolyl cis-trans-isomerase Peptidyl-prolyl cis-trans isomerases; cyp-2 is a predicted member of the cytosolic CyclosporinA- binding cyclophilin family that is functional when expressed in E. coli. ZK524.1 spe-4;ZK524.1 Member of the presenilin protein family required for spermatogenesis integral membrane protein SPE-4; spe-4 encodes a transmembrane protein that is a divergent member of the presenilin family of proteins that have been implicated in early-onset Alzheimer's disease (OMIM:104300); spe-4 activity is required for proper formation and function of the fibrous body-membranous organelles that are asymmetrically localized to spermatids during spermatogeneis; spe-4 is also required for proper partitioning of tubulin as spermatids bud from the residual body; spe-4 localizes to the fibrous body-membranous organelles of developing spermatocytes and also to the spermatozoon cell body. ZK524.2 ZK524.2 Putative ortholog of C. elegans unc-13 gene product UNC-13 protein; unc-13 encodes at least five protein isoforms that regulate neurotransmitter release by altering the conformation of syntaxin; UNC-13 proteins are required for normal pharyngeal pumping and thrashing in liquid, normally short lifespan, normally large brood sizes, and full adult body sizes; UNC-13 proteins have orthologs in vertebrates and Drosophila; UNC-13 proteins are complex, with multiple C2, phorbol ester-binding, and DUF1041 domains; UNC-13 protein form is localized to most or all synapses; many of the unc-13 mutant alleles with viable phenotypes are transcript-specific, while homozygotes with an unc-13 null (deletion) allele die as paralyzed first-stage larvae. ZK524.3 ZK524.3 Member of the class I isoleucyl, leucyl, valyl, and methionyl (I, L, M, and V) tRNA synthetase family, has moderate similarity to human KIAA0028, which is a mitochondrial leucyl-tRNA synthetase leucyl-tRNA synthetase (mitochondrial) ZK524.4 ZK524.4 Protein containing a protein kinase domain, has a region of high similarity to a region of SNRK protein kinase (rat SNRK), which may play a role in regulation of low potassium-induced apoptosis in cultured cerebellar granule neurons serine/threonine kinase ZK525.1 flp-15;ZK525.1 FMRF-amide-like-peptide neurotransmitter flp-15 encodes two FMRFamide-related short peptide neurotransmitter; the precise roles for these peptides in C. elegans neurotransmission are not yet known. ZK525.2 ZK525.2 Protein of unknown function, has low similarity to uncharacterized C. elegans ZK1321.3 ZK546.1 ZK546.1 Putative coiled-coil protein, has weak similarity to S. cerevisiae Uso1p, required for protein transport from ER to Golgi cytoskeletal linker protein ZK546.11 ZK546.11 Protein containing glutathione S-transferase N- and C-terminal domains, has moderate similarity to prostaglandin D2 synthase (human PGDS), which is a prostaglandin D synthase and glutathione S-transferase that regulates non-rapid eye movement sleep glutathione S-transferase ZK546.13 ZK546.13 Protein of unknown function ZK546.14 ZK546.14 Putative coiled-coil protein, has weak similarity to S. cerevisiae spindle pole body component Nuf1p, has weak similarity to C. elegans myosin family member NMY-1 ZK546.15 ZK546.15 Member of the trypsin family of serine proteases, has low similarity to proprostasin (human PRSS8), which is a precursor of active membrane-bound serine protease secreted into seminal fluid that may be a suppressor of invasive prostate and breast cancer Plasminogen ZK546.2 ZK546.2 Protein containing 13 leucine rich repeats, which mediate protein-protein interactions, has low similarity to C. elegans SOC-2, which is a positive regulator of the let-60 ras pathway and vulval induction Adenylate cyclase ZK546.3 ZK546.3 Protein with very strong similarity to C. elegans MSP-142, which is a sperm-specific protein involved in sperm motility, contains a major sperm protein (MSP) domain, which are involved in sperm motility Major sperm protein ZK546.4 ZK546.4 Protein of unknown function ZK546.5 ZK546.5 Protein containing four C2H2 type zinc finger domains, which bind nucleic acids Zinc finger protein ZK546.6 msp-152;ZK546.6 Sperm-specific protein involved in sperm motility, member of the major sperm protein (MSP) family Major sperm protein; msp-152 encodes a protein that belongs to a family of proteins called the Major Sperm Proteins (MSPs) that is conserved in nematodes; this family consists of closely related, small, basic proteins that make up 15% of sperm protein; this multigene family consists of over fifty genes, including many pseudogenes; MSPs are involved in both extracellular signaling and cytoskeletal functions during reproduction-MSP antagonizes Eph/ephrin signaling, in part, by binding VAB-1 Eph receptor tyrosine kinase on oocytes and sheath cells to promote oocyte maturation and MAPK activation; MSPs assemble into fibrous networks that drive movement of the C. elegans sperm; msp genes are expressed only in late primary spermatocytes. ZK546.7 ZK546.7 Protein of unknown function, has very strong similarity to uncharacterized C. elegans Y59E9AL.3 ZK550.1 ZK550.1 Member of the membrane bound O-acyl transferase (MBOAT) family, which are found in acyltransferase enzymes, has high similarity to uncharacterized C. elegans C08F8.4 ZK550.2 ZK550.2 Protein of unknown function, has high similarity to uncharacterized C. elegans T28C12.2 ZK550.3 ZK550.3 Member of the M3 peptidase family of zinc metalloproteases, has a region of weak similarity to proteinase yscD (saccharolysin, S. cerevisiae Prd1p) ZK550.4 ZK550.4;ceTFIIEalpha Member of the TFIIE alpha subunit family of general transcription factors, has low similarity to general transcription factor IIE polypeptide 1 (56 kDa alpha subunit, human GTF2E1), which is required for initiation of basal level transcription ZK550.5 ZK550.5 Protein with high similarity to phytanoyl-CoA hydroxylase (human PHYH), which catalyzes the conversion of phytanoyl-CoA to 2-hydroxyphytanoyl-CoA in fatty acid alpha-oxidation and is associated with Refsum disease ZK550.6 ZK550.6 Protein with high similarity to phytanoyl-CoA hydroxylase (human PHYH), which catalyzes the conversion of phytanoyl-CoA to 2-hydroxyphytanoyl-CoA in fatty acid alpha-oxidation and is associated with Refsum disease The ZK550.6 gene encodes an ortholog of the human gene PHYTANOYL-COA HYDROXYLASE (PHYH; PAHX; OMIM:602026), which when mutated leads to Refsum disease (OMIM:266500). ZK563.1 uvt-7;ZK563.1 Protein of unknown function, has a region of low similarity to a region of solute carrier family 2 member 9 (human SLC2A9), which is a plasma membrane protein that is involved in the transport of glucose uvt-7 encodes a transmembrane permease of the major facilitator superfamily (MFS) that by homology, is predicted to transport metabolites across cellular membranes in response to chemiosmotic gradients; uvt-7 was first identified in molecular analyses of gene products linked to the vitellogenin (vit) loci on the X chromosome; as loss of uvt-7 activity via large-scale RNAi screens does not result in any obvious abnormalities, the precise role of uvt-7 in C. elegans development and/or behavior is not yet known; uvt-7 mRNA is detected in embryos and adults, suggesting that uvt-7 may be a maternally expressed gene. ZK563.2 ZK563.2 Putative sodium-dependent phosphate transporter sodium-dependent phosphate transporter ZK563.3 ZK563.3 Member of the transposase family, which are required for excising and inserting mobile genetic elements, has strong similarity to uncharacterized C. elegans F47G9.5 transposase ZK563.4 ZK563.4 Protein of unknown function clc-3 encodes a claudin homolog that may regulate ion channels; CLC-3 is worm-specific, with a highly divergent sequence weakly similar to mammalian voltage-dependent calcium channel gamma subunits that are known or suspected to prevent epilepsy in vivo (e.g., stargazin; MGI:1316660); claudins are integral membrane proteins with four transmembrane sequences that are found in mammalian tight junctions (TJs), induce TJs when transgenically expressed in cells normally lacking them, and can mediate the specific conductance of of specific ions (e.g., magnesium or calcium) through TJs while blocking the flow of water. ZK563.5 ZK563.5 Protein of unknown function ZK563.6 ZK563.6 Member of the histidine acid phosphatase family, which hydrolyze phosphate esters at low pH, has weak similarity to prostatic acid phosphatase (human ACPP), which dephosphorylates oncoprotein ERBB2 and negatively regulates cell growth ZK593.1 ZK593.1 Protein with high similarity to pyruvate kinase 3 (rat Pkm2), which converts phosphoenolpyruvate to pyruvate with concomitant phosphorylation of ADP to ATP in glycolysis, contains a pyruvate kinase barrel (active) domain and alpha or beta domain pyruvate kinase ZK593.2 ZK593.2 Protein of unknown function ZK593.3 ZK593.3 Protein of unknown function ZK593.4 ZK593.4 Putative ortholog of human RBP2, a retinoblastoma binding protein Human XE169 like ZK593.5 dnc-1;ZK593.5 Component of dynactin complex dynactin; DNC-1 encodes a dynactin, orthologous to Drosophila GLUED, that is required for pronuclear migration and centrosome separation in one-cell embryos and for the correct alignment of mitotic spindles in early embryos; DNC-1 shares embryonic functions with DNC-2, DHC-1, LIS-1 and NUD-1; DNC-1 is located at cortical microtubule attachment sites. ZK593.6 ZK593.6 Protein with high similarity to microtubule-associated proteins 1A/1B light chain 3 (rat MPL3), which is a cytoskeletal regulator and subunit of microtubule-associated proteins, member of the microtubule associated protein 1A or 1B light chain 3 family microtubule-associated protein 1 like; lgg-2 encodes a homolog of the light chain 3 (LC3) subunit of the microtubule-associated proteins 1A and 1B (MAP1A and MAP1B); by homology, LGG-2 is predicted to associate with MAP1A and MAP1B and with microtubules and to perhaps play a role in regulating the microtubule-binding activity of MAP1A and MAP1B; in C. elegans, loss of lgg-2 activity via RNAi does not result in any obvious abnormalities and specifically, does not appear to affect autophagy as required for dauer formation and life-span extension. ZK593.7 ZK593.7 Protein with high similarity to S. cerevisiae Lsm7p, which is a U6 snRNA-associated protein, member of the Sm family, which are core constituents of snRNP complexes Yeast JTA107 like ZK593.8 ZK593.8 Protein of unknown function, has a region of high similarity to huntingtin interacting protein E (human HYPE), which binds normal and mutant huntingtin (human HD) and may have a role in the pathogenesis of Huntington's disease ZK593.9 ZK593.9 Protein containing a protein kinase domain, has low similarity to fyn-related kinase (B-cell src-homology tyrosine kinase, mouse Frk), which is a non-receptor protein tyrosine kinase involved in cell proliferation control and upregulated in mammary tumors tyrosine-protein kinase ZK596.1 ZK596.1 Protein containing a DUF148 domain of unknown function, has high similarity to uncharacterized C. elegans C28C12.4 ZK596.2 ZK596.2 Protein containing a protein kinase domain, has low similarity to casein kinase 1 alpha 1 (rat Csnk1a1), which is a serine/threonine protein kinase that may play a role in signal transduction serine/threonine kinase ZK596.3 ZK596.3 Protein of unknown function, has weak similarity to uncharacterized C. elegans M03F8.1 ZK6.1 ZK6.1 Protein containing nuclear hormone receptor C4-type zinc finger and ligand-binding domains, has low similarity to C. elegans NHR-51, which is involved in developmental processes ZK6.10 ZK6.10 Protein of unknown function, has high similarity to uncharacterized C. elegans ZK6.11 ZK6.11 ZK6.11 Protein of unknown function, has high similarity to uncharacterized C. elegans ZK6.10 ZK6.2 ZK6.2 Protein containing nuclear hormone receptor C4-type zinc finger and ligand-binding domains, has low similarity to C. elegans NHR-51, which is involved in developmental processes zinc finger protein ZK6.3 ZK6.3 Protein of unknown function, has low similarity to uncharacterized C. elegans T19C9.5 ZK6.4 ZK6.4 Protein containing nuclear hormone receptor C4-type zinc finger and ligand-binding domains, has low similarity to C. elegans NHR-51, which is involved in developmental processes zinc finger protein ZK6.5 ZK6.5 Protein containing nuclear hormone receptor C4-type zinc finger and ligand-binding domains, has low similarity to a region of C. elegans NHR-51, which is involved in developmental processes zinc finger protein ZK6.6 ZK6.6 Protein of unknown function, has high similarity to uncharacterized C. elegans ZK6.8 ZK6.7 ZK6.7 Protein with moderate similarity to lipase gastric (human LIPF), which is a serine esterase lipase expressed in the stomach that catalyzes the hydrolysis of dietary triacylglycerol substrates and plays a role in neutral lipid metabolism lipase ZK6.8 ZK6.8 Protein of unknown function, has high similarity to uncharacterized C. elegans B0554.5 ZK6.9 ZK6.9 Member of the 7-transmembrane chemoreceptor family of G-protein coupled receptors (GPCR), has high similarity to a region of uncharacterized C. elegans T27E7.2 7TM chemoreceptor, srh family ZK616.A ZK616.10;ZK616.A Protein with moderate similarity to C. elegans F12E12.5 gene product ZK616.B ZK616.9;ZK616.B Protein of unknown function ZK616.C ZK616.8;ZK616.C Putative ortholog of C. elegans M04G7.2 gene product ZK616.D ZK616.7;ZK616.D Putative ortholog of C. elegans M04G7.2 gene product ZK616.E ZK616.6;ZK616.E Protein of unknown function ZK616.F ZK616.5;ZK616.F Putative ortholog of C. elegans Y73B6BL.23 gene product ZK616.G ZK616.4;ZK616.G Putative ortholog of C. elegans act-1 gene product ZK616.H ZK616.3;ZK616.H Protein with moderate similarity to C. elegans ZK616.2 gene product ZK616.I ZK616.2;ZK616.I Protein with moderate similarity to C. elegans ZK616.3 gene product ZK616.J ZK616.1;ZK616.J Protein with weak similarity to C. elegans C18A3.5 gene product ZK617.1 ZK617.1 Protein with strong similarity to C. elegans UNC-22, which is a serine-threonine protein kinase that may regulate contraction, contains a protein kinase domain, 21 immunoglobulin (Ig) domains, and 31 fibronectin type III domains Fibronectin type III domain (31 domains), IG (immunoglobulin) superfamily (18 domains), calcium/calmodulin dependent protein kinase; unc-22 encodes twitchin, a giant intracellular protein with multiple fibronectin- and immunoglobulin-like domains and a single protein kinase domain that is homologous to titin (OMIM:188840); UNC-22 is required in muscle for regulation of the actomyosin contraction-relaxation cycle and for maintenance of normal muscle morphology; UNC-22 associates with myosin and is localized to A-bands; in vitro, UNC-22 can phosphorylate myosin light-chain peptides and can undergo autophosphorylation. ZK617.2 ZK617.2 Member of the class 2 lipase family, has moderate similarity to uncharacterized C. elegans C09E8.2 ZK617.3 spe-17;ZK617.3 Protein involved in spermatogenesis spermatogenesis-defective protein SPE-17 like ZK622.1 ZK622.1 Protein containing a Src homology 2 (SH2) domain, which are regulatory modules of intracellular signaling, and a protein kinase domain, has moderate similarity to fer (mouse Fes related) tyrosine kinase (mouse Fert2), which may mediate cell-cell signaling tyrosine-protein kinase ZK622.2 ZK622.2 Protein of unknown function, has strong similarity to uncharacterized C. elegans K09E4.5 ZK622.3 ZK622.3 Protein with weak similarity to S. cerevisiae YBR261C ZK622.4 ZK622.4 Protein with strong similarity to C. elegans K02C4.4 gene product ZK632.1 ZK632.1 Has high similarity to minichromosome maintenance deficient 6 (human MCM6), which has ATP-dependent helicase activity and may have a role in initiation of DNA replication, member of the MCM family of DNA-dependent ATPases Mcm2/3; mcm-6 encodes a protein that has similarity to human DNA replication licensing factor MCM6 and affects embryonic viability. ZK632.10 ZK632.10 Member of the uncharacterized protein family UPF0057 ZK632.11 ZK632.11 Protein with strong similarity to C. elegans Y34D9A.7 gene product ZK632.12 ZK632.12 Protein with similarity to human early endosomal protein EEA1, member of the FVVE zinc finger protein family PH (pleckstrin homology) domain ZK632.13 ZK632.13 Protein of unknown function lin-52 encodes a novel protein that is most closely related to the Drosophila melanogaster CG15929 protein and the human protein XP_040376; lin-52 is a class B synthetic multivulva (synMuv) gene that appears to function with lin-35/Rb to negatively regulate vulval development; in addition, lin-52 is also required for germline and larval development. ZK632.2 ZK632.2 Protein containing one double-stranded RNA binding domain and one forkhead associated (FHA) domain, which bind phosphopeptides, has low similarity to uncharacterized solute carrier family 4 (anion exchanger) member 1 adapter protein (human SLC4A1AP) Coiled coil protein ZK632.3 ZK632.3 Member of the uncharacterized RIO1-ZK632.3-MJ0444 family, has moderate similarity to uncharacterized sudD (suppressor of bimD6 Aspergillus nidulans) homolog (human SUDD) Hypothetical protein 186 (T. acidophilum) ZK632.4 ZK632.4 Member of the phosphomannose isomerase type I family, has moderate similarity to phosphomannose isomerase (human MPI), which supplies D-mannose derivatives for glycosylation reactions and is associated with congenital disorders of glycosylation type Ib Mannose 6-phosphate isomerase; ZK632.4 is orthologous to the human gene PHOSPHOMANNOSE ISOMERASE (MPI; OMIM:154550), which when mutated leads to disease. ZK632.5 ZK632.5 Protein of unknown function ZK632.6 cnx-1;ZK632.6 Member of the calreticulin protein family of calcium-binding proteins, has moderate similarity to calnexin (mouse Canx), which is a lectin-binding protein that functions as a chaperone in the endoplasmic reticulum and plays a role in protein transport Calnexin; cnx-1 encodes the C. elegans ortholog of calnexin, a transmembrane calcium-binding protein that localizes to the endoplasmic reticulum; by homology, CNX-1 is predicted to function as a molecular chaperone that is required for glycoprotein folding and maturation as well as for regulation of intracellular calcium homeostasis; although loss of cnx-1 activity via large-scale RNAi screens does not result in any obvious abnormalities, genetic studies indicate that cnx-1 RNAi can suppress the necrotic-like cell death induced by hyperactive mutations in the MEC-4 and DEG-1 ion channels; thus, in addition to its proposed role in glycoprotein processing, CNX-1 is also required for necrotic-like neuronal death. ZK632.7 ZK632.7 Protein with low similarity to S. cerevisiae Pan3p, which is a component of the S. cerevisiae Pab1p -stimulated poly(A) ribonuclease ZK632.8 arl-2;ZK632.8 Protein with high similarity to S. cerevisiae Arf2p, which is a GTP-binding protein that is involved in assembly of coated vesicles, member of the ADP-ribosylation factor (ARF) family, which are GTP-binding proteins involved in protein trafficking ADP ribosylation factor; arl-5 encodes a paralog of the ADP-ribosylation factor-like protein EVL-20; ARL-5 is an ortholog of mammalian ARL5. ZK632.9 ZK632.9 Protein of unknown function ZK637.1 YOU1;ZK637.1 Protein related to mammalin synaptic vesicle protein SVOP, member of the major facilitator superfamily Sugar transporter ZK637.10 ZK637.10 Member of the reductase/oxidoreductase protein family Glutathione reductase; This gene encodes a protein predicted by Eisenberg and coworkers, with 68% accuracy, to be mitochondrial. ZK637.11 ZK637.11 Protein containing a rhodanese-like domain, has a region of moderate similarity to a region of C. elegans K06A5.7, which is in involved in cell division CDC25/string; cdc-25.3 encodes a tyrosine phosphatase that is a member of the cell division cycle 25 (CDC25) family of cell cycle regulators that includes Schizosaccharomyces pombe CDC25 and Drosophila string; cdc-25.3 is one of four cdc-25 genes in C. elegans and while it is known to be expressed in hermaphrodites, the precise function of cdc-25.3 is not yet clear; cdc-25.3 may function redundantly with cdc-25.2 during embryonic development and redundantly with cdc-25.1, cdc-25.2, and emb-29 during meiosis. ZK637.12 ZK637.12 Protein of unknown function, has strong similarity to uncharacterized C. elegans Y57G11C.1 ZK637.13 ZK637.13;ORF1 Member of the globin family of oxygen transporters Globin ZK637.14 ZK637.14 Protein containing a C3HC4 type (RING) zinc finger, which may mediate protein-protein interactions Zinc finger, C3HC4 type (RING finger) ZK637.15 ZK637.15 Protein of unknown function, has high similarity to uncharacterized C. elegans ZK637.12 ZK637.2 ZK637.2 Protein of unknown function ZK637.3 ZK637.3 Protein of unknown function ZK637.4 ZK637.4 Protein of unknown function ZK637.5 ZK637.5 Protein with high similarity to arsenite transporter ATP-binding homolog 1 (human ASNA1), which is a putative arsenite transporter, member of the anion-transporting ATPase family, which are involved in removal of arsenate and antimonite from the cell ArsA ZK637.7 lin-9;lin-9l;lin-9s;ZK637.7 Part of the class B pathway that antagonizes vulval induction and is required for male tail andgonad development ZK637.8 ZK637.8 Putative ortholog of C. elegans unc-32 gene product TJ6/proton pump; unc-32 encodes six isoforms of a highly conserved vacuolar H+-ATPase a subunit (V-ATPase) homologous to the vertebrate a1 proteins that have been implicated in a number of human diseases including osteopetrosis (OMIM:259700); UNC-32 is predicted to function as part of an ATP-dependent proton pump that regulates acidification of intracellular compartments and is essential for locomotion and embryonic and larval development; UNC-32 is expressed throughout the life cycle, with early and broad expression detectable in the embryo, and larval and adult expression detectable in the gut, gonad, and neurons. ZK637.9 ZK637.9 Protein with low similarity to thiamine pyrophosphokinase (mouse Tpk1), which catalyzes the pyrophosphorylation of thiamine using ATP as a phosphate donor ZK643.1 ZK643.1 Protein of unknown function, has weak similarity to C. elegans F35F10.12 ZK643.2 ZK643.2 Member of the cytidine and deoxycytidylate deaminase zinc-binding region protein family; expressed in hypodermis during late cleavage DCMP Deaminase ZK643.3 ZK643.3 Member of the B family of 7 transmembrane (TM) peptide receptors Calcitonin receptor family ZK643.5 ZK643.5 Protein expressed in some neurons during the L1 larval stage ZK643.6 ZK643.6 Protein containing a DUF18 domain of unknown function, has low similarity to uncharacterized C. elegans F01D5.1 ZK643.7 ZK643.7 Protein of unknown function ZK652.1 ZK652.1 Protein with high similarity to sm protein F (human SNRPF), which is a spliceosomal snRNA-associated Sm core protein involved in snRNP biogenesis and a target of autoantibodies in systemic lupus erythematosus, member of the Sm family small nuclear ribonucleoprotein Sm F (snRNP core protein F) ZK652.10 ZK652.10 Protein of unknown function ZK652.11 ZK652.11 Protein with strong similarity to C. elegans cuc-1 gene product ZK652.2 ZK652.2 Small protein of unknown function, has strong similarity to human 6.2 kD protein (Hs.112318) ZK652.3 ZK652.3;3H949 Protein of unknown function, has strong similarity to uncharacterized human BM-002 ZK652.4 ZK652.4 Member of the ribosomal protein L35 protein family 60S ribosomal protein L35; rpl-35 encodes a large ribosomal subunit L35 protein. ZK652.5 ceh-23;ZK652.5 Homeodomain transcription factor; has similarity over the homeodomain to many human and D. melanogaster homeodomain transcription factors distal-less homeotic protein; The ceh-23 gene encodes a homeodomain protein required for a specific differentiated trait of the thermosensory interneuron AIY. ZK652.6 ZK652.6 Protein containing a ZZ zinc finger domain Zinc finger protein ZK652.8 ZK652.8 Protein of unknown function ZK652.9 ZK652.9 Member of the ubiE/COQ5 methyltransferase protein family coq-5 encodes a putative ubiquinone biosynthesis methyltransferase, homologous to COQ5 in S. cerevisiae and a family of methyltransferases involved in ubiquinone, menaquinone, biotin and sterol biosynthesis and in phosphatidylethanolamine methylation; COQ-5 is required for ubiquinone biosynthesis and for normally short lifespan; coq-5(RNAi) animals have reduced levels of coenzyme Q8, coenzyme Q9, and superoxide, and have abnormally long lifespans. ZK662.2 ZK662.2 Protein of unknown function ZK662.3 nhr-48;ZK662.3 Member of the nuclear hormone receptor/Zinc finger protein family Zinc finger, C4 type (two domains) ZK662.4 lin-15B;lin-15;ZK662.4 Negative regulator of the LET-23 receptor-tyrosine kinase, LET-60 ras signaling pathway LIN-15B protein ZK662.5 ZK662.5 Putative paralog of C. elegans lin-15B (Negative regulator of the LET-23 receptor-tyrosine kinase, LET-60 ras signaling pathway) ZK666.1 ZK666.1 Protein of unknown function, has strong similarity to uncharacterized C. elegans ZK673.10 ZK666.10 ZK666.10 Member of the 7-transmembrane chemoreceptor family of G protein-coupled receptors (GPCR), has high similarity to uncharacterized C. elegans Y102A5C.29 ZK666.2 ZK666.2 Protein of unknown function, has weak similarity to C. elegans F36D1.4 ZK666.3 ZK666.3 Member of the C-type lectin protein family Lectin C-type domain short and long forms, von Willebrand factor type A domain ZK666.4 ZK666.4 Protein of unknown function, has strong similarity to uncharacterized C. elegans ZK673.10 ZK666.5 ZK666.5 Member of the C-type lectin protein family Lectin C-type domain short and long forms ZK666.6 ZK666.6 Member of the C-type lectin protein family von Willebrand factor type A domain ZK666.7 ZK666.7 Member of the C-type lectin protein family Lectin C-type domain short and long forms, von Willebrand factor type A domain ZK666.8 ZK666.8 Protein containing a protein kinase domain, has low similarity to casein kinase 1 gamma 1 (rat Csnk1g1), which is a serine/threonine protein kinase that may play roles in cell growth and in morphogenesis serine/threonine kinase ZK669.1 ZK669.1 Protein with strong similarity to human PARG1, PTPL1-associated RhoGAP 1 N-chimaerin ZK669.2 ZK669.2 Protein of unknown function, has low similarity to uncharacterized mouse Ifi30 ZK669.3 ZK669.3 Protein of unknown function, has low similarity to uncharacterized C. elegans Y18D10A.2 ZK669.4 ZK669.4 Protein containing an E3 binding, a biotin or lipoyl attachment, and a 2-oxo acid dehydrogenases acyltransferase catalytic domain, has low similarity to dihydrolipoamide acetyltransferase E2 (human DLAT), which is the primary biliary cirrhosis autoantigen lipoamide acyltransferase; ZK669.4 is orthologous to the human gene DIHYDROLIPOAMIDE BRANCHED CHAIN TRANSACYLASE (E2 COMPONENT OF BRANCHED CHAIN KETO ACID DEHYDROGENASE COMPLEX; (DBT), which when mutated leads to maple syrup urine disease, type II (OMIM:248610); the ZK669.4 protein is predicted to be mitochondrial with 68% accuracy. ZK669.5 ZK669.5 GTP-binding protein of the ras superfamily Ras-like protein ZK673.1 ZK673.1 Protein of unknown function, has moderate similarity to C. elegans E04D5.4 ZK673.10 ZK673.10 Member of an uncharacterized protein family ZK673.2 ZK673.2 Member of the adenylate kinase family, has moderate similarity to adenylate kinase 3 alpha like (human AKL3L), which is a mitochondrial enzyme with GTP:AMP phosphotransferase activity that is involved in adenine nucleotide homoeostasis adenylate kinase; This gene encodes a protein predicted by Eisenberg and coworkers, with 52% accuracy, to be mitochondrial. ZK673.3 ZK673.3 Protein of unknown function, has weak similarity to C. elegans ZK673.4 ZK673.4 ZK673.4 Protein containing a BED zinc finger domain ZK673.5 ZK673.5 Member of an uncharacterized protein family ZK673.6 ZK673.6 Protein of unknown function ZK673.7 tnc-2;ZK673.7 Trponin C troponin C; tnc-2 encodes pharyngeal muscle troponin C, the calcium-binding component of the troponin complex of actin thin filaments; TNC-2 is essential for postembryonic development, and by homology, likely functions to regulate pharyngeal muscle contraction in response to changes in intracellular calcium; TNC-2 is expressed exclusively in pharyngeal muscle. ZK673.9 ZK673.9 Member of the C-type lectin protein family Lectin C-type domain short and long forms, von Willebrand factor type A domain ZK675.1 ptc-1;ZK675.1 Putative ortholog of D. melanogaster membrane protein PTC (patched), involved in patterning within segments membrane protein patched; ptc-1 is orthologous to Drosophila patched and human PTC; mutation of human PTC leads to nevoid basal cell carcinoma syndrome (OMIM:109400). ZK675.2 ZK675.2 Member of the impB, mucB or samB family, contains one BRCA1 (breast cancer type 1) C terminus (BRCT) domain, has a region of low similarity to a region of DNA template-dependent dCMP transferase (human REV1L), which functions in translesion DNA synthesis DNA repair protein (REV1) ZK675.3 ZK675.3 Member of the C. elegans putative membrane protein family 8, has moderate similarity to a region of bestrophin (human VMD2), which plays a role in vision and is associated with several macular pathologies ZK675.4 ZK675.4 Protein of unknown function ZK678.1 lin-15A;lin-15;ZK678.1 Negative regulator of vulval development LIN-15A protein; lin-15A encodes a novel, hydrophilic protein; LIN-15A activity is required non-cell autonomously to negatively regulate vulval development; genetic analysis indicates that lin-15A, a class A synMuv gene, functions upstream of the LET-23 receptor tyrosine and redundantly with class B synMuv genes, such as lin-15B and lin-35 Rb and class C synMuv genes such as trr-1 and mys-1; although the lin-15A expression pattern is not yet known, genetic mosaic analysis suggests that, in regulating vulval induction, LIN-15A functions outside of the six vulval precursor cells P(3-8).p, likely acting instead in the surrounding hypodermal tissue. ZK678.2 ZK678.2 Protein containing a nuclear hormone receptor C4-type zinc finger domain, which bind DNA and may function in transcription, and a nuclear hormone receptor ligand-binding domain, has low similarity to estrogen-related receptor beta (human ESRRB) Ligand-binding domain of nuclear hormone receptors, Zinc finger, C4 type (two domains) ZK678.3 ZK678.3 Protein of unknown function, has strong similarity to C. elegans W05G11.2 cyclin like ZK678.4 ZK678.4 Protein of unknown function, has strong similarity to C. elegans R04D3.10 ZK678.5 wrt-4;M75;ZK678.5 Protein with weak similarity to the C-terminus of Drosophila hedgehog Hint module ZK678.6 ZK678.6 Protein with similarity to G protein-coupled receptors of the SRG subfamily, no homolog found in human or D. melanogaster, may have fewer than 7 predicted transmembrane domains G-protein coupled receptor, srg family ZK682.2 ZK682.2 Protein with similarity to human and D. melanogaster sodium-dependent inorganic phosphate cotransporters, member of the major facilitator superfamily sodium/phophate transporter ZK682.4 CeABF-1;ZK682.4 Contains a helix-loop-helix domain, has similarity to human transcription factor 21 (TCF21); can act like a transcritptional repressor helix-loop-helix ZK682.5 ZK682.5 Protein containing ten leucine rich repeats, which mediate protein-protein interactions, has low similarity to a region of C. elegans SYM-1, which is required for attachment of body muscle to cuticle in absence of MEC-8 ZK682.7 ZK682.7 Protein of unknown function ZK686.1 ZK686.1 Protein with weak similarity to C. elegans Y106G6H.3 ATP-dependent RNA helicase ZK686.2 ZK686.2 Member of the RNA helicase, DEAD-box protein family ATP-dependent RNA helicase ZK686.3 ZK686.3 Protein of unknown function, has strong similarity to human N33 protein (Hs.71119) ZK686.3 is orthologous to the putative tumor suppressor N33 (OMIM:601385, associated with homozygous deletion in metastatic prostate cancer and with loss of function in other tumors); ZK686.3 is also homologous to the S. cerevisiae dolichyl-diphosphooligosaccharide-protein glycotransferase gamma chain (34-kD) subunit, OST3. ZK686.4 ZK686.4 Protein with strong similarity to C. elegans T07F8.1 gene product ZK688.1 ZK688.1 Protein of unknown function ZK688.2 ZK688.2 Member of the C. elegans putative membrane protein family 8, has a region of moderate similarity to bestrophin (human VMD2), which plays a role in vision and is associated with several macular pathologies ZK688.3 ZK688.3 Member of the fumarylacetoacetate (FAA) hydrolase family, which hydrolyze fumarylacetoacetate into fumarate and acetoacetate, has high similarity to uncharacterized human DKFZP566J2046 ZK688.4 ZK688.4 Protein of unknown function ZK688.5 ZK688.5 Member of the ubiquitin family ZK688.6 ZK688.6 Member of the alpha or beta hydrolase fold family, has moderate similarity to prolylcarboxypeptidase (angiotensinase C, human PRCP), which cleaves the C-terminal amino acid residues linked to proline and is associated with essential hypertension ZK688.7 ZK688.7 Protein containing a major sperm protein (MSP) domain, which are involved in sperm motility ZK688.8 gly-3;ZK688.8 N-acetylgalactosaminyltransferase UDP-GalNAc; gly-3 encodes an N-acetylgalactosaminyltransferase that is functional in vitro. ZK688.9 ZK688.9 Putative ortholog of C. elegans C02C2.6 gene product ZK697.1 ZK697.1 Protein containing a DUF216 domain of unknown function, has low similarity to uncharacterized C. elegans C08F11.2 ZK697.10 ZK697.10 Member of the 7-transmembrane chemoreceptor family of G protein-coupled receptors (GPCR), has low similarity to C. elegans ODR-10, which is a G protein-coupled receptor that is involved in odorant response 7TM chemoreceptor, str family ZK697.11 ZK697.11 Member of the 7-transmembrane chemoreceptor family of G protein-coupled receptors (GPCR), has high similarity to uncharacterized C. elegans F47D2.10 7TM chemoreceptor, srh family ZK697.2 ZK697.2 Protein containing a nuclear hormone receptor ligand-binding domain and a nuclear hormone receptor C4-type zinc finger domain, which bind DNA and may be involved in regulation of transcription, has weak similarity to C. elegans NHR-80 zinc finger protein ZK697.3 ZK697.3 Protein of unknown function ZK697.4 ZK697.4 Member of the 7-transmembrane chemoreceptor family of G protein-coupled receptors (GPCR), has high similarity to uncharacterized C. elegans B0454.3 7TM chemoreceptor, sri family ZK697.5 ZK697.5 Protein of unknown function, has weak similarity to uncharacterized C. elegans K12D9.10 7TM chemoreceptor, srw family ZK697.6 ZK697.6 Protein containing glutathione S-transferase N-terminal and C-terminal domains, has low similarity to prostaglandin D2 synthase (human PGDS), which acts as prostaglandin D synthase and glutathione S-transferase and regulates non-rapid eye movement sleep glutathione S-transferase ZK697.7 ZK697.7 Protein of unknown function, has moderate similarity to uncharacterized C. elegans R13D11.6 7TM chemoreceptor, srab family ZK697.8 ZK697.8 Member of the transthyretin precursor family of thyroxine binding proteins ZK721.1 ZK721.1 Protein of unknown function, has low similarity to uncharacterized human FLJ20174 tag-130 encodes a predicted transmembrane protein; as loss of tag-130 activity via RNAi does not result in any abnormalities, the precise role of TAG-130 in C. elegans development and/or behavior is not yet known; however, TAG-130 is homologous to SID-1, a channel protein required for systemic RNA interference, and thus TAG-130 may be predicted to also function as a channel; a tag-130 reporter fusion is widely expressed in larval and adult stages and detected in such tissues as body wall muscle, hypodermis, intestine, pharynx, and the gonad. ZK721.2 ZK721.2 Member of the troponin family, which regulate calcium-induced muscle contraction, has high similarity to uncharacterized C. elegans T20B3.2 troponin I ZK721.3 ZK721.3 Protein of unknown function ZK721.4 ZK721.4 Member of the rhodopsin family of G protein-coupled receptors (GPCR) Adenosine A3 receptor ZK742.1 ZK742.1 Protein with high similarity to exportin 1 (human XPO1), which is a cell cycle-regulated nuclear export receptor that mediates NES-containing protein export from the nucleus and may be required for autophagy importin beta, nuclear transport factor; imb-4 encodes exportin-1, an importin-beta-like protein orthologous to Drosophila, vertebrate, and yeast exportin-1/CRM1; IMB-4 is predicted to function as a nuclear export receptor for proteins containing leucine-rich nuclear export signals; in C. elegans, IMB-4 is essential for embryogenesis and larval development, and may also be required for normal body morphology and postembryonic growth rates. ZK742.2 ZK742.2 Protein of unknown function ZK742.3 ZK742.3 Member of the NADH:flavin oxidoreductase or NADH oxidase family, which reduce a range of alternative electron acceptors, has a region of low similarity to a region of NADPH dehydrogenase isoform 2 (old yellow enzyme isoform 2, S. cerevisiae Oye2p) ZK742.4 ZK742.4 Member of the NADH:flavin oxidoreductase or NADH oxidase family, which reduce a range of alternative electron acceptors, has moderate similarity to uncharacterized C. elegans ZK742.3 ZK742.5 lbp-4;ZK742.5 Member of the lipocalin and cytosolic fatty-acid binding protein family, has high similarity to uncharacterized C. elegans LBP-3 ZK75.1 ins-4;ZK75.1 Insulin-like protein of the type-beta subfamily ZK75.2 ins-2;ZK75.2 Insulin-like protein of the type-beta subfamily ZK75.3 ins-3;ZK75.3 Member of type-beta subfamily of insulin-like proteins ins-3 encodes one of several insulin-related peptides; INS-3 is classified as a Type-beta insulin based on the predicted arrangement of disulfide bonds; gfp gene fusions with the promoter and enhancer regions indicate that INS-3 is expressed in some amphid sensory neurons. ZK757.1 ZK757.1 Protein containing a DHHC-type zinc finger (NEW1) domain, has a region of low similarity to a region of huntingtin interacting protein H (human HYPH), which binds the antiapoptotic protein Huntingtin (HD) and is associated with Huntington's disease ZK757.2 ZK757.2 Member of the dual specificity phosphatase, catalytic domain protein family protein-tyrosine phosphatase ZK757.3 ZK757.3 Piwi-related protein with similarity over the C-terminal region to human and D. melanogaster PIWI proteins and C. elegans PRG-1 and PRG-2, all of which are involved in germ-line proliferation ZK770.1 ZK770.1 Member of the amiloride-sensitive sodium channel family, which are involved in sodium reabsorption, has low similarity to C. elegans MEC-4, which is involved in mechanosensory perception degenerin ZK770.3 ZK770.3 Member of the integral membrane innexin family, which are involved in the formation of gap junctions, has moderate similarity to C. elegans UNC-9, which is required for normal locomotion inx-12 (innexin=invertebrate connexin analogue) encodes a protein of the innexin family; innexins are gap junction proteins similar in function, though dissimilar in sequence to the vertebrate connexins; innexins are the only known gap junction proteins in invertebrates; inx-12 and inx-13 appear to be a tandom duplication; RNA interference of inx-12 results in an arrest at the L1 larval stage with fluid filled dead rods; this phenotype and sequence homology to Drosophila innexins suggest that INX-12 may be required to form gap junctions between the excretory canal and hypodermis, thus playing an essential role in osmoregulation; an INX-12::GFP fusion protein is expressed in the excretory canal. ZK783.1 ZK783.1 Protein containing fifteen epidermal growth factor (EGF)-like domains, has weak similarity to fibrillin-1 (mouse Fbn1), which is an extracellular matrix protein of connective tissue microfibrils that is associated with the tight skin (Tsk) disorder ZK783.1 is homologous to human fibrillin-1 (FBN1), which when mutated leads to Marfan syndrome (OMIM:154700). ZK783.2 ZK783.2 Member of the protein-tyrosine phosphatase family, which are involved in control of cell growth, proliferation, differentiation, and transformation, member of the phosphorylase family, has a region of high similarity to uridine phosphorylase (mouse Upp) tyrosine phosphatase ZK783.3 ZK783.3 Protein with strong similarity to C. elegans F57H12.5 gene product ZK783.4 flt-1;ZK783.4 Protein containing a zinc finger domain and a putative bromodomain, has weak similarity to human WBSCR10 (Williams-Beuren syndrome chromosome region 10 and region 9) flt-1 encodes a putative homolog of flectin, an extracellular matrix protein thought to provide a microenvironment of great elasticity; however, FLT-1 protein contains no similarity to other ECM components, instead mostly appearing to be made up of chromatin or DNA-binding domains; FLT-1 also contains a glutamine/asparagine-rich domain, which may mediate epigenetic regulation. ZK792.1 ZK792.1 Protein of unknown function, contains a histidine acid phosphatase signature domain, has similarity over a region of the C-terminus to S. cerevisiae Aut2p Histidine acid phosphatases ZK792.2 inx-8;ZK792.2 Member of the integral membrane innexin family, which are involved in the formation of gap junctions, has low similarity to C. elegans INX-3, which is an innexin that forms connexin-like intercellular channels Ogre family; inx-8 encodes a predicted member of the innexin family that affects fertility; expressed in sheath cells. ZK792.3 inx-9;ZK792.3 Member of the integral membrane innexin family, which are involved in the formation of gap junctions, has low similarity to a region of C. elegans INX-3, which is an innexin that forms connexin-like intercellular channels Ogre family; inx-9 encodes an innexin, an integral transmembrane channel protein that is a structural component of invertebrate gap junctions; although the precise role of INX-9 in C. elegans development and/or behavior is not yet known, INX-9 may play a role in gonad or germline development, as INX-9 expression is detected solely in the sheath cells of the somatic gonad and particularly, the sheath cells in contact with proximal oocytes. ZK792.4 ZK792.4 Protein containing eight ankyrin (Ank) repeats, which may mediate protein-protein interactions, has low similarity to a region of espin (rat Espn), which is an actin bundling protein associated with deafness upon loss of function ankyrin like ZK792.5 ZK792.5 Protein containing three Pumilio-family (Puf) RNA binding domains Pumilio-family RNA binding domains (aka PUM-HD, Pumilio homology domain) (3 domains) ZK792.6 let-60;lin-34;let-60ras;ZK792.6 Ras protein, GTP-binding protein of the ras superfamily that specifies cell fates required for larval development and vulva formation LET-60 RAS protein; The let-60 gene encodes a member of the GTP-binding RAS protooncogene family that affects viability, vulval development, spicule development, germ line meiotic progression, posterior development of the hypodermis, and chemotaxis; it acts genetically downstream of let-23 with respect to vulval development and upstream of the MAPK pathway with respect to chemotaxis, and is expressed in neural, muscle, and hypodermal lineages. ZK792.7 ZK792.7 Protein with weak similarity to S. cerevisiae Cdc1p, involved in ion homeostasis Yeast CC1 like ZK792.8 ZK792.8 Protein with strong similarity to D. melanogaster CG6194 (CG6194 gene product) ZK795.1 ZK795.1 Protein of unknown function, has a region of low similarity to a region of inositol polyphosphate multikinase (rat Ipmk), which catalyzes the formation of Ins-1,4,5-P3, Ins-1,3,4,5-P4, Ins-1,3,4,5,6-P5 and 5-pyrophosphate-InsP4 ZK795.2 ZK795.2 Protein of unknown function ZK795.3 ZK795.3 Protein with high similarity to S. cerevisiae Imp4p, which is a component of U3 snoRNP and required for pre-18S rRNA processing, contains an IMP4 domain of unknown function ZK809.1 ZK809.1 Putative paralog of C. elegans C29E6.3, has similarity to C. elegans C15H7.3, a member of the protein-tyrosine phosphatase protein family protein-tyrosine phosphatase ZK809.2 ZK809.2 Putative ortholog of H. sapiens tafazzin, mutated in Barth syndrome cardiomyopathy tag-145/ZK809.2 encodes an ortholog of human tafazzin (TAZ; OMIM:300394, mutated in Barth syndrome). ZK809.3 ZK809.3 Protein of unknown function ZK809.4 ZK809.4 Member of an uncharacterized protein family hydrophobic nucleolar protein like; ent-1 encodes a predicted equilibrative nucleoside transporter 1 that affects growth. ZK809.5 ZK809.5 Protein containing a G protein gamma like (GGL) domain ZK809.7 ZK809.7 Protein containing a C3HC4 type (RING) zinc finger, has weak similarity to peroxisomal membrane protein 3 (mouse Pxmp3), which may function in neuronal migration and is associated with abnormal neuronal migration resulting from defective lipid metabolism Zinc finger, C3HC4 type (RING finger); prx-2 is orthologous to the human gene PEROXISOMAL MEMBRANE PROTEIN 3 (PXMP3; OMIM:170993), which when mutated leads to Zellweger syndrome 3 or infantile Refsum disease. ZK813.1 ZK813.1 Protein of unknown function ZK813.2 ZK813.2 Protein of unknown function ZK813.3 ZK813.3 Protein of unknown function ZK813.4 ZK813.4 Protein of unknown function ZK816.1 ZK816.1 Protein of unknown function ZK816.3 ZK816.3 Protein of unknown function ZK816.4 ZK816.4 Expressed in the pharynx ZK816.5 ZK816.5 Member of the short-chain dehydrogenase-reductase family, which are NAD- or NADP-dependent oxidoreductases, has high similarity to uncharacterized C. elegans Y32H12A_57.F short-chain alcohol dehydrogenase; dhs-26 encodes a short-chain dehydrogenase predicted to be mitochondrial. ZK822.1 ZK822.1 Protein of unknown function ZK822.2 ZK822.2 Protein containing two DUF148 domains of unknown function ZK822.4 ZK822.4 Protein containing a DUF148 domain of unknown function ZK822.5 ZK822.5 Member of the sodium:solute symporter family of membrane transporters, has low similarity to rat Slc5a6, which is a sodium-dependent multivitamin transporter that mediates the electrogenic uptake of pantothenate, biotin, and lipoate by cells sodium/proline symporter like ZK829.1 ZK829.1 Member of the short-chain dehydrogenase-reductase family, which are NAD- or NADP-dependent oxidoreductases, has low similarity to C. albicans Sou1p, which is a l-sorbose dehydrogenase involved in utilization of L-sorbose dehydrogenase; This gene encodes a protein predicted by Eisenberg and coworkers, with 68% accuracy, to be mitochondrial. ZK829.10 ZK829.10 Member of the sodium:neurotransmitter symporter family, has weak similarity to solute carrier family 6 member 2 (mouse Slc6a2), which is a norepinephrine norepinephrine transporter involved in reuptake that interacts with tricyclic antidepressants sodium-dependent neurotransmitter symporter like ZK829.2 ZK829.2 Protein containing a pyridoxal-dependent group II decarboxylase conserved domain, which bind pyridoxal-phosphate groups, has a region of moderate similarity to dopa decarboxylase (aromatic L-amino acid decarboxylase, rat Ddc) aromatic-L-amino-acid decarboxylase ZK829.3 ZK829.3 Protein of unknown function ZK829.4 ZK829.4 Member of the glutamate dehydrogenase (NADP+) protein family glutamate dehydrogenase; ZK829.4 is orthologous to the human gene GLYCINE DECARBOXYLASE PRECURSOR (GLUD1; OMIM:238300), which when mutated leads to disease. ZK829.5 ZK829.5 Protein containing a T-box domain, which bind DNA ZK829.6 ZK829.6 Member of the queuine tRNA-ribosyltransferase family, which modify tRNAs for asparagine, aspartic acid, histidine and tyrosine with queuine, has high similarity to uncharacterized mouse Tgut queuine tRNA-ribosyltransferase; tgt-1 encodes a tRNA-guanine transglycosylase predicted to be mitochondrial. ZK829.7 ZK829.7 Member of the zinc-containing alcohol dehydrogenase family, which catalyze reversible oxidation of ethanol to acetaldehyde, has low similarity to mouse Sdh1, which is a sorbitol dehydrogenase that catalyzes the interconversion of sorbitol and fructose alcohl dehydrogenase like ZK829.8 ZK829.8 Member of the 7-transmembrane chemoreceptor family of G protein-coupled receptors (GPCR), has low similarity to uncharacterized C. elegans T28A11.10 ZK829.9 ZK829.9 Member of the sugar (and other) transporter family, has weak similarity to facilitative glucose transporter 3 (mouse Slc2a3), which is a high-affinity glucose transporter glucose transporter ZK836.1 lon-3;ZK836.1 Protein with high similarity to C. elegans ROL-6, which is a putative collagen that is involved in morphogenesis of an epithelium, contains four collagen triple helix repeats and two nematode cuticle collagen N-terminal domains collagen ZK836.2 ZK836.2 Member of the glutarate dehydrogenase protein family 2-oxoglutarate dehydrogenase; This gene encodes a protein predicted by Eisenberg and coworkers, with 68% accuracy, to be mitochondrial. ZK836.3 vab-8;unc-107;ZK836.3 Protein required for some cell migrations and growth cone outgrowth ZK84.1 ZK84.1 Protein of unknown function, has low similarity to a region of nascent-polypeptide-associated complex alpha subunit (mouse Naca), which binds JUN, enhances JUN-mediated transcription, and functions in myogenesis ZK84.2 ZK84.2 Protein of unknown function, has high similarity to uncharacterized C. elegans Y38H6C.16 ZK84.3 ins-5;ZK84.3 Insulin-like protein of the type-beta subfamily ins-5 encodes an insulin-like peptide of the insulin superfamily of proteins (OMIM:176730, 147440); INS-5 is one of 38 insulin-like peptides in C. elegans and is expressed in the amphid sensory neurons, labial neurons, the nerve ring, other neurons, and the vulva; the precise role of INS-5 in C. elegans development is not yet clear as loss of function does not result in a mutant phenotype. ZK84.4 ZK84.4 Protein of unknown function, has strong similarity to uncharacterized C. elegans AH10.4 ZK84.5 ZK84.5 Protein with moderate similarity to C. elegans W05F2.1 gene product ZK84.6 ins-6;ZK84.6 Insulin-like protein of the type-beta subfamily ins-6 encodes predicted type-beta insulin-like molecule that lacks a C peptide domain; expressed throughout development and in some neurons beginning in the two-fold elongated embryo. ZK849.1 ZK849.1 Protein containing a PDZ, DHR, or GLGF domain, which are found in signaling proteins PDZ domain (Also known as DHR or GLGF). ZK849.2 ZK849.2 Protein contains a PDZ (DHR, GLGF) domain PDZ domain (Also known as DHR or GLGF). ZK849.4 ZK849.4 Member of the C. elegans putative membrane protein family 8, has low similarity to a region of bestrophin (human VMD2), which plays a role in vision and is associated with several macular pathologies Putative membrane protein ZK849.5 ZK849.5 Member of the C. elegans putative membrane protein family 8, has low similarity to a region of bestrophin (human VMD2), which plays a role in vision and is associated with several macular pathologies Putative membrane protein ZK856.1 cul-5;ZK856.1 Member of the cullin family of cell cycle control proteins Cullin family; cul-5 encodes a cullin, orthologous to vasopressin-activated calcium-mobilizing receptor-1 in mammals, that is thought to regulate the cell cycle by virtue of its paralogy to cul-1 and cul-2; however, CUL-5 is dispensable for viability and gross morphology in mass RNAi screens, and does not appear to interact with any of 17 Skp1-related proteins (SKR-1 through SKR-21). ZK856.10 ZK856.10 Protein with low similarity to RNA polymerase III subunit C25 (S. cerevisiae Rpc25p) DNA directed RNA polymerase III ZK856.11 ZK856.11 Protein of unknown function ZK856.12 ZK856.12 Protein of unknown function, has moderate similarity to uncharacterized C. elegans C06A5.6 ZK856.13 ZK856.13 Protein of unknown function transcription factor ZK856.2 ZK856.2 TcA transposase Tc1 transposase ZK856.3 ZK856.3 Protein of unknown function, has a region of low similarity to a region of sphingomyelin phosphodiesterase 1 (acid sphingomyelinase, mouse SMPD1), which converts sphingomyelin to ceramide and plays a role in inflammation ZK856.4 ZK856.4 Protein of unknown function ZK856.5 ZK856.5 Protein of unknown function, has moderate similarity to the N-terminus of H. sapiens Hs.123659 gene product, an ASM-like phosphodiesterase ZK856.6 ZK856.6 Protein of unknown function, has high similarity to uncharacterized C. elegans B0416.2 ZK856.7 ZK856.7 Protein of unknown function ZK856.8 ZK856.8 Protein with high similarity to calcineurin B homologous protein (human CHP), which is a Ca2+-binding protein that inhibits Na+-H+ exchanger activity and calcineurin phosphatase activity, contains three EF hand domains EF-hand calcium binding protein ZK856.9 ZK856.9 Protein of unknown function ZK858.1 ZK858.1 Protein containing a nucleotidyltransferase domain, has a region of moderate similarity to a region of polymerase sigma (DNA topoisomerase-related function 4, human POLS), which acts in DNA damage repair and sister chromatid cohesion S.pombe hypothetical protein C12G12.13C like ZK858.2 ZK858.2 Protein of unknown function ZK858.3 ZK858.3 Member of the lectin protein family lectin ZK858.4 mel-26;ZK858.4 Negative regulator of the meiotic-spindle protein MEI-1 kruppel-like zinc-finger protein; mel-26 encodes a MATH and BTB/POZ domain-containing protein that functions as a novel substrate-specific adaptor of the CUL-3-containing E3 ubiquitin ligase; MEL-26 is required maternally for formation of mitotic spindles in the early embryo, and as a component of a ubiquitin ligase complex, for degradation of the microtubule-severing protein MEI-1 at the meiosis to mitosis transition; MEL-26 is also required maternally for embryonic morphogenesis; since MEL-26 contains a meprin-associated Traf homology (MATH) domain, it might be involved in apoptosis. ZK858.5 ZK858.5 Protein of unknown function ZK858.6 ZK858.6 Member of the COPII coat protein, Emp70p-like protein family ZK858.7 ZK858.7 Protein of unknown function, has low similarity to uncharacterized C. albicans Orf6.7071p ZK863.1 ZK863.1 Protein of unknown function, has high similarity to uncharacterized C. elegans C04C3.6 7 transmembrane receptor (rhodopsin family) ZK863.2 col-35;ZK863.2 Protein containing two collagen triple helix repeats and one nematode cuticle collagen N-terminal domain, has a region of high similarity to a region of collagen type V alpha 2 subunit (human COL5A2), which is involved in connective tissue maintenance collagen ZK863.3 ZK863.3 Protein with high similarity to S. cerevisiae Elp3p, which is a subunit of the RNA polymerase II elongator holoenzyme and has histone acetyltransferase activity, contains an acetyltransferase (GNAT) domain Yeast LPG22P protein like ZK863.4 ZK863.4 Protein of unknown function ZK863.5 ZK863.5 Member of the 7-transmembrane chemoreceptor family of G protein-coupled receptors (GPCR), has moderate similarity to uncharacterized C. elegans C39H7.6 7TM chemoreceptor (srd-family) ZK863.6 dpy-30;ZK863.6 Protein involved in regulation of X-linked, dosage-compensated genes DPY-30 protein; The dpy-30 gene encodes an essential nuclear protein required for hermaphrodite dosage compensation as well as normal male development; DPY-30 is expressed ubiquitously throughout development and can be detected in two different multiprotein complexes: the SDC complex involved in dosage compensation and a second complex containing NOX-1 (a WD repeat-containing protein) and ASH-2 (a trithorax-related protein) that is homologous to the yeast Set1p complex involved in epigenetic regulation of transcription. ZK863.7 rnp-1;ZK863.7 Protein containing an RNA recognition motif (RRM, RBD, or RNP) and a zinc knuckle domain, which can bind RNA or DNA in eukaryotes RNP-1 protein ZK867.1 ZK867.1 Protein containing eight C2H2 type zinc finger domains, which bind nucleic acids, has a region of low similarity to a region of human replication initiation region protein 60 kDa (RIP60), which binds DNA and may be involved in DNA replication zinc finger ZK867.2 ZK867.2 Protein with moderate similarity to C. elegans C08B6.5 ZK892.1 lec-3;ZK892.1 Protein with high similarity to galectin (C. elegans LEC-1), which is a galactoside-binding lectin, member of the galectin family galactoside-binding lectin ZK892.2 nlt-1;ZK892.2 Member of the SCP-2 sterol transfer family, has moderate similarity to a region of sterol carrier protein 2 (non-specific lipid transfer protein, human SCP2), which acts in phospholipid exchange between membranes and stimulates cholesterol metabolism lipid transfer protein; nlt-1 encodes a member of the SCP-2 sterol transfer family. ZK892.3 ZK892.3 Member of the sugar (and other) transporter family, has low similarity to organic cation transporter 2 (rat Slc22a7), which is a multispecific sodium-independent organic anion transporter that mediates uptake of nucleoside analogs and several drugs transport protein ZK892.4 ZK892.4 Putative ortholog of H. sapiens alpha-methylacyl-CoA racemase protein L-carnitine dehydratase; ZK892.4 is orthologous to the human gene ALPHA-METHYLACYL-CoA RACEMASE (AMACR; OMIM:604489), which when mutated leads to AMACR deficiency. ZK892.5 ZK892.5 Protein of unknown function ZK892.6 ZK892.6 Protein of unknown function, has moderate similarity to C. elegans F16B12.6 ZK892.7 ZK892.7 Protein of unknown function, has a region of low similarity to a region of C. elegans HAM-2, which is a target for the HOX family member C. elegans EGL-5 and is a likely transcription factor required for hermaphrodite-specific neuron migration Zinc finger, C2H2 type ZK896.1 ZK896.1 Protein of unknown function, has moderate similarity to uncharacterized C. elegans ZK896.4 ZK896.2 ZK896.2 Protein of unknown function, has high similarity to uncharacterized C. elegans ZK896.3 ZK896.3 ZK896.3 Protein containing a DUF141 domain of unknown function, has high similarity to uncharacterized C. elegans ZK896.4 ZK896.4 ZK896.4 Protein containing a DUF141 domain of unknown function, has high similarity to uncharacterized C. elegans ZK896.5 ZK896.5 ZK896.5 Protein containing a DUF141 domain of unknown function, has high similarity to uncharacterized C. elegans ZK896.4 ZK896.6 ZK896.6 Member of the C-type lectin family, has similarity to human C-type mannose receptor MRC1 lectin (C-type) ZK896.7 ZK896.7 Putative paralog of C. elegans Y73C8C.2, has similarity at the N-terminus to C. elegans F38A1.5, a member of the phospholipase A2 receptor protein family lectin (C-type) ZK896.8 gcy-18;gcy-26;ZK896.8 Protein containing a receptor family ligand binding domain, a protein kinase domain and an adenylate and guanylate cyclase catalytic domain, has low similarity to C. elegans DAF-11, which is a guanylate cyclase that is involved in chemosensation guanylate cyclase; gcy-18 encodes a predicted guanylate cyclase whose expression is induced in daf-16(RNAi); daf-2(RNAi) double mutants and repressed in daf-2(RNAi) mutants; this profile was obtained by microarray analysis and may reflect a contribution by GCY-18 to a shortened lifespan. ZK896.9 ZK896.9 Protein with moderate similarity to solute carrier family 35 UDP-N-acetylglucosamine transporter member 3 (human SLC35A3), which transports nucleotide sugars CMP-sialic acid transporter ZK897.1 unc-31;egl-22;ZK897.1 Protein which mediates calcium-regulated secretion, has weak similarity to H. sapiens and rat CADPS (ca2+-dependent activator protein for secretion) PH (pleckstrin homology) domain; unc-31 encodes a pleckstrin homology (PH) domain-containing protein orthologous to human calcium-dependent activator protein for secretion (CADPS, OMIM:604667); UNC-31 functions in post-docking calcium-regulated dense-core vesicle fusion that is required for egg laying, locomotion, pharyngeal pumping, and recovery from the dauer larval stage; in addition, UNC-31 functions in the insulin receptor signaling pathway that regulates adult life span where it may control Ca[2+]-regulated secretion of an insulin-like ligand. ZK899.1 ZK899.1 Protein of unknown function ZK899.2 ZK899.2 Protein of unknown function ZK899.3 ZK899.3 Protein of unknown function ZK899.4 ZK899.4 Protein with high similarity to keratinocyte alpha-tubulin (human K-ALPHA-1), which may contribute to antimitotic drug resistance, member of the tubulin-FtzA family, which are involved in polymer formation tubulin alpha chain; tba-8 encodes a member of the alpha tubulin family with high similarity to the human tubulin alpha-6 chain; expressed in some neurons with occasional expression in the hypodermis. ZK899.5 ZK899.5 Protein of unknown function, has strong similarity to uncharacterized C. elegans ZK899.6 ZK899.6 ZK899.6 Protein of unknown function, has strong similarity to uncharacterized C. elegans ZK899.5 ZK899.7 ZK899.7 Protein of unknown function ZK899.8 gap-2-4;ZK899.8 Member of the Ras GTPase-activating protein family, contains a C2 domain, which may be involved in calcium-dependent phospholipid binding, has a region of moderate similarity to a region of synaptic Ras GTPase activating protein (rat SYNGAP) GTPase-activating protein; gap-2 encodes a Ras GTPase-activating protein (RasGAP) that is orthologous to mammalian nGAP and synGAP (OMIM:606136, OMIM:603384, synGAP is essential for postnatal survival and neuronal development); by homology, GAP-2 is predicted to function as a negative regulator of Ras signaling by enhancing the intrinsically weak Ras GTPase activity; gap-2 loss-of-function mutations partially suppress the larval lethality of let-23 and let-60 loss-of-function mutations, supporting a role for gap-2 in negative regulation of Ras signaling in vivo; gap-2 can encode at least eight different isoforms that appear to be expressed in a wide variety of tissues including the vulva, gonad, pharynx, neurons, and blast/rectal cells of the tail. ZK909.1 ZK909.1 Protein of unknown function ZK909.2 kin-1;CeCatalpha;ZK909.2;ZK909.2;ZK909.2 Putative cAMP-dependent protein kinase; serine/threonine protein kinase with strong similarity to human, D. melanogaster, and S. cerevisiae cAMP-dependent protein kinase catalytic subunits Protein kinase C terminal domain; kin-1 encodes multiple isoforms of a serine/threonine protein kinase that is orthologous to cAMP-dependent protein kinase (protein kinase A or PKA) catalytic subunits; KIN-1 is able to phosphorylate histone H2B in vitro and is associated with both particulate (~65%) and cytosolic (35%) cellular fractions; KIN-1 is expressed at low levels during embryogenesis, but its expression level increases in late embryogenesis, whereupon KIN-1 expression remains relatively high throughout larval and adult development; kin-1 mRNA levels, however, are fairly constant throughout development, suggesting that KIN-1 expression is regulated post-transcriptionally; as loss of kin-1 activity via large-scale RNAi screens results in no obvious defects, the precise role of kin-1 in C. elegans development and/or behavior is not yet known. | kin-1 encodes multiple isoforms of predicted serine/threonine protein kinases, some of which are myristoylated, with similarity to protein kinase A catalytic subunits. ZK909.3 ZK909.3 Protein of unknown function guanosine-3',5'-bis(diphosphate)-pyrophosphohydrolase like; This gene encodes a protein predicted by Eisenberg and coworkers, with 52% accuracy, to be mitochondrial. ZK909.4 ces-2;ZK909.4 Putative transcriptional repressor; required for normal programmed cell death albumin D-binding protein like; ces-2 encodes a basic region leucine-zipper (bZIP) transcription factor, most similar in sequence and binding specificity to the PAR (proline- and acid-rich) subfamily of bZIP proteins; ces-2 is required to activate programmed cell death in the sister cells of the serotoninergic neurosecretory motor (NSM) neurons, and is transcriptionally inhibited by activated LET-60(G12V). ZK909.5 ZK909.5 Protein of unknown function, has weak similarity to uncharacterized C. elegans H24O09.2 ZK930.1 ZK930.1 Protein with strong similarity to S. cerevisiae Vps15p. a serine/threonine protein kinase involved in vacuolar protein sorting serine/threonine kinase ZK930.2 ZK930.2 Protein of unknown function ZK930.3 ZK930.3 Protein of unknown function ZK930.4 ZK930.4 Protein of unknown function, has moderate similarity to uncharacterized C. elegans C26B2.2 ZK930.5 ZK930.5 Protein of unknown function, has weak similarity to C. elegans R03H10.1 ZK930.6 ZK930.6 Protein with weak similarity to C. elegans T23G4.2 gene product ZK930.7 ZK930.7 Protein of unknown function, has high similarity to uncharacterized C. elegans C26B2.2 ZK938.1 ZK938.1 Member of the protein phosphatase protein family serine/threonine protein phosphatase ZK938.2 ZK938.2 Protein of unknown function, has low similarity to uncharacterized C. elegans T04B8.3 ZK938.3 ZK938.3 Protein containing an IQ calmodulin-binding domain calgranulin C calcium binding domains ZK938.4 ZK938.4 Protein of unknown function, has low similarity to uncharacterized C. elegans T20D4.6 arrestin like protein ZK938.5 old-2;tkr-2;ZK938.5 Protein with strong similarity to C. elegans OLD-1, which is a putative receptor tyrosine protein kinase that extends lifespan upon overproduction, contains a protein kinase domain tyrosine-protein kinase (KIN15/KIN16 subfamily); old-2 encodes a transmembrane protein tyrosine kinase (also known as 'kin-28') that affects mean and maximum life span with multiple paralogs in C. elegans; the expression of old-2 was experimentally verified by RT-PCR. ZK938.6 ZK938.6 Member of the glycosyl hydrolase 18 family, has a region of weak similarity to chitinase 3-like 3 (mouse Chi3l3), which is a lectin with chitinase activity that is chemotactic for eosinophils, bone marrow polymorphonuclear leukocytes, and T lymphocytes chitinase domains ZK938.7 ZK938.7 Member of the RNase H family, which digest the RNA strand of an RNA-DNA duplex ribonuclease H magnesium binding domain ZK945.1 ZK945.1 Protein of unknown function, has moderate similarity to uncharacterized C. elegans M28.6 esterase ZK945.10 lov-1;ZK945.9;ZK945.10 Similar to mammalian PKD1 (polycystic kidney disease) proteins; required for males to locate the hermaphrodite vulva ZK945.2 pas-7;ZK945.2 Putative alpha-type subunit of 20S proteasome particle proteasome component (A-type) ZK945.3 ZK945.3 Protein of unknown function, has low similarity to uncharacterized C. albicans Orf6.4654p pumilio-repeat like domain ZK945.4 ZK945.4 Protein of unknown function ZK945.5 ZK945.5 Member of the B-box zinc finger family, has low similarity to a region of ADP-ribosylation factor domain protein 1 (human ARFD1), which is a GTPase that may play a role in vesicle trafficking between the Golgi and lysosomes and in lysosome function ARD1 ZK945.6 ZK945.6 Protein of unknown function ZK945.7 ZK945.7 Protein of unknown function ZK945.8 ZK945.8 Protein of unknown function, has high similarity to C. elegans K10H10.7 ZK970.1 ZK970.1 Member of the M13 peptidase family of zinc metalloproteases, has low similarity to endothelin-converting enzyme 1 (human ECE1), which is a membrane-bound protease that generates endothelin vasoconstrictors and is associated with developmental defects neprilysin zinc protease; ZK970.1 encodes, by alternative splicing, two isoforms of a neprilysin; neprilysins are thermolysin-like zinc metallopeptidases, found on the outer surface of animal cells, that negatively regulate small signalling peptides (e.g., enkephalin, tachykinin, insulin, and natriuretic peptides) by cleaving them; ZK970.1 has no clear orthologs in other organisms. ZK970.2 ZK970.2 Member of the ATP-dependent Clp family of serine endopeptidases CLPP-like protease ZK970.3 ZK970.3 Protein of unknown function, moderate similarity to uncharacterized surfeit 5 (mouse Surf5) ZK970.4 ZK970.4 Protein with high similarity to vacuolar H(+)-ATPase proton pump 14kDa subunit F (rat VATF), which is a part of the peripheral catalytic sector and may couple the ATP hydrolytic sector to proton channels, member of the synthase F (14-kDa) subunit family H+-transporting ATPase ZK970.5 gcy-4;ZK970.5 Putative guanylyl cyclase guanylate cyclase ZK970.6 gcy-5;ZK970.6 Putative guanylyl cyclase expressed in the ASER neuron guanylate cyclase; gcy-5 encodes a predicted guanylate cyclase with strong similarity to rat atrial natriuretic peptide receptor A; expressed in ASER. ZK970.7 ZK970.7 Protein containing a DUF148 domain of unknown function, has high similarity to uncharacterized C. elegans C06A8.3 OV-17 antigen precursor ZK971.1 ZK971.1 Protein of unknown function ZK973.1 ZK973.1 Protein with strong similarity to D. melanogaster CG5253 (CG5253 gene product) ZK973.10 ZK973_14.B;ZK973.B;ZK973.10 Protein with high similarity to NADH dehydrogenase (ubiquinone) Fe-S protein 4 (mouse Ndufs4), which is a a nuclear-encoded subunit of NADH:ubiquinone oxidoreductase that is activated upon phosphorylation by cAMP lpd-5 is orthologous to the human gene NADH DEHYDROGENASE (UBIQUINONE) FE-S PROTEIN 4 (18KD) (NADH-COENZYME Q REDUCTASE) (NDUFS4; OMIM:602694), which when mutated leads to NADH:ubiquinone oxidoreductase (complex I) deficiency. ZK973.11 ZK973.11 Putative paralog of C. elegans ZK973_14.A thioredoxin ZK973.2 ZK973.2 Protein of unknown function, putative paralog of C. elegans ZK973_14.M ZK973.3 ZK973.3 Putative paralog of C. elegans ZK973_14.K phosphatase ZK973.4 ZK973.4 Protein of unknown function, putative paralog of C. elegans ZK973_14.J ZK973.5 acr-6;ZK973.5 Putative paralog of C. elegans unc-38 (Nicotinic acetylcholine receptor alpha subunit) acetylcholine receptor subunit ZK973.6 ZK973.6 Putative paralog of C. elegans ZK973_14.I anc-1 encodes a 8546-residue protein, orthologous of Drosophila Msp-300 and mammalian Syne proteins, which may extend more than 0.5 micrometers in vivo; ANC-1 has coiled regions, a nuclear envelope localization domain (the KASH domain) and an actin-binding domain; ANC-1 affects the positioning of nuclei and mitochondria within the cytoskeleton; ANC-1 is expressed in the cytoplasm, but localized to the nuclear periphery in an UNC-84-dependent manner. ZK973.8 ZK973.8 Protein of unknown function, putative paralog of C. elegans ZK973_14.D ZK973.9 ZK973_14.C;ZK973.C;ZK973.9 Protein of unknown function, has low similarity to uncharacterized synovial sarcoma translocation (mouse Ss18), which is a putative transcription factor ZK993.1 ZK993_103.C;ZK993.C;ZK993.1 Protein containing a homeobox domain (homeodomain), which are found in transcription factors, has a region of high similarity to a region of goosecoid (mouse Gsc), which is a transcription factor that is required for craniofacial and rib development homeobox protein ZK993.2 ZK993.2 Protein of unknown function, putative paralog of C. elegans ZK993_103.B ZK993.3 ZK993.3 Protein of unknown function, has moderate similarity to C. elegans ZK993_103.A ZK994.1 ZK994.1 Member of the carboxylesterase type B family, has low similarity to carboxylesterase 1 (monocyte-macrophage serine esterase 1, rat Ces1), which is a liver esterase carboxylesterase ZK994.3 ZK994.3 Member of the animal heme peroxidase family, contains two immunoglobulin (Ig) domains, has moderate similarity to myeloperoxidase (human MPO), which mediates neutrophil activity against microbial pathogens and malignant cells peroxidase ZK994.4 ZK994.4 Protein containing leucine rich repeat C-terminal and N-terminal cysteine rich domains and five leucine rich repeats, has low similarity to a region of slit homolog 1 (Drosophila) (mouse Slit1), which is a ligand for mouse Robo1 ZK994.6 ZK994.6 Protein of unknown function